WorldWideScience

Sample records for burst suppression level

  1. Burst Suppression: A Review and New Insights

    Directory of Open Access Journals (Sweden)

    Jonathan Dillon Kenny

    2014-12-01

    Full Text Available Burst suppression is a pattern of brain electrical activity characterized by alternating periods of high-amplitude bursts and electrical silence. Burst suppression can arise from several different pathological conditions, as well as from general anesthesia. Here we review current algorithms that are used to quantify burst suppression, its various etiologies, and possible underlying mechanisms. We then review clinical applications of anesthetic-induced burst suppression. Finally, we report the results of our new study showing clear electrophysiological differences in burst suppression patterns induced by two common general anesthetics, sevoflurane and propofol. Our data suggest that the circuit mechanisms that generate burst suppression activity may differ between different general anesthetics.

  2. The Etiology and Outcome Analysis of Neonatal Burst Suppression EEG

    Institute of Scientific and Technical Information of China (English)

    ZHANG Lian; ZHOU Yanxia; XU Sanqing

    2007-01-01

    The neonatal burst suppression is a severe EEG pattern and always demonstrates serious damage of nerve system. But the outcome of these patients depends on the different etiology. A total of 256 cases of video EEG recordings were analyzed in order to summarize the etiology and outcome of burst suppression. The results showed that some patients in all 17 cases of burst suppression showed EEG improvement. The etiology was the dominant factor in long term outcome. It was sug-gested that effective video EEG monitoring is helpful for etiologic study and prognosis evaluation.

  3. Detection of burst suppression patterns in EEG using recurrence rate.

    Science.gov (United States)

    Liang, Zhenhu; Wang, Yinghua; Ren, Yongshao; Li, Duan; Voss, Logan; Sleigh, Jamie; Li, Xiaoli

    2014-01-01

    Burst suppression is a unique electroencephalogram (EEG) pattern commonly seen in cases of severely reduced brain activity such as overdose of general anesthesia. It is important to detect burst suppression reliably during the administration of anesthetic or sedative agents, especially for cerebral-protective treatments in various neurosurgical diseases. This study investigates recurrent plot (RP) analysis for the detection of the burst suppression pattern (BSP) in EEG. The RP analysis is applied to EEG data containing BSPs collected from 14 patients. Firstly we obtain the best selection of parameters for RP analysis. Then, the recurrence rate (RR), determinism (DET), and entropy (ENTR) are calculated. Then RR was selected as the best BSP index one-way analysis of variance (ANOVA) and multiple comparison tests. Finally, the performance of RR analysis is compared with spectral analysis, bispectral analysis, approximate entropy, and the nonlinear energy operator (NLEO). ANOVA and multiple comparison tests showed that the RR could detect BSP and that it was superior to other measures with the highest sensitivity of suppression detection (96.49%, P = 0.03). Tracking BSP patterns is essential for clinical monitoring in critically ill and anesthetized patients. The purposed RR may provide an effective burst suppression detector for developing new patient monitoring systems.

  4. Detection of Burst Suppression Patterns in EEG Using Recurrence Rate

    Directory of Open Access Journals (Sweden)

    Zhenhu Liang

    2014-01-01

    Full Text Available Burst suppression is a unique electroencephalogram (EEG pattern commonly seen in cases of severely reduced brain activity such as overdose of general anesthesia. It is important to detect burst suppression reliably during the administration of anesthetic or sedative agents, especially for cerebral-protective treatments in various neurosurgical diseases. This study investigates recurrent plot (RP analysis for the detection of the burst suppression pattern (BSP in EEG. The RP analysis is applied to EEG data containing BSPs collected from 14 patients. Firstly we obtain the best selection of parameters for RP analysis. Then, the recurrence rate (RR, determinism (DET, and entropy (ENTR are calculated. Then RR was selected as the best BSP index one-way analysis of variance (ANOVA and multiple comparison tests. Finally, the performance of RR analysis is compared with spectral analysis, bispectral analysis, approximate entropy, and the nonlinear energy operator (NLEO. ANOVA and multiple comparison tests showed that the RR could detect BSP and that it was superior to other measures with the highest sensitivity of suppression detection (96.49%,  P=0.03. Tracking BSP patterns is essential for clinical monitoring in critically ill and anesthetized patients. The purposed RR may provide an effective burst suppression detector for developing new patient monitoring systems.

  5. Burst-suppression pattern in the electroencephalogram of newborns and infants. Its clinical expression

    Directory of Open Access Journals (Sweden)

    Cervantes Blanco Jorge Mauricio

    2014-07-01

    Full Text Available Burst-suppression pattern in the electroencephalogram (EEG is associated with severe brain damage and has a bad prognosis in 85% of the cases. Objectives. To identify the prevalence of the EEG burst-suppression pattern (BSP in fullterm newborns and infants, determine its etiol- ogy, clinical features and course. Methods. A retrospective study was conducted. Between January 2008 and December 2012, 4,891 EEGs were reviewed. The EEGs of newborns and infants (< 3 months of age with BSP were selected. Results. 11 cases identified with burst suppression pattern. The overall prevalence of which was 3.5%; 8.1% among the newborns and 1.2% among infants. Seizures were the main reason for doing an EEG in the newborn period in 7 patients and after day 28 in three. The clinical manifestations were abnormal level of consciousness (n=8, hypotonia (n=2, and spasticity (n=6. The main causes were hypoxic ischemic injury, stroke and kernicterus. There were two cases of early infantile epileptic encephalopathy. Two patients died before the third month of age; 8 survived an average of 13 months. All had epilepsy, neurologic retardation and disability. Two patients had persistent EEG burst-suppression pattern; 1 and 3 months after the neonatal period respectively; 7 had focal spikes and an asymmetric pattern. Conclusions. Electroencephalographic burst-suppression pat- tern predicts a severe neurologic injury in fullterm newborns and infants.

  6. Hanging-induced burst suppression pattern in EEG

    Directory of Open Access Journals (Sweden)

    Nilgun Cinar

    2012-01-01

    Full Text Available Lethal suspension (hanging is one of the most common methods of attempting suicide. Spinal fractures, cognitive and motor deficits as well as epileptic seizures can be detected after unsuccessful hanging attempts. Introduced here is the case of a 25-year-old man exemplifying the clinical observations stated hereafter, who was conveyed to our emergency room after having survived attempted suicide by hanging, with his post-anoxic burst-suppression electroencephalography (BS-EEG pattern and clinical diagnoses in the post-comatose stage. The patient′s state of consciousness was gradually improved over a period of time. His neuropsychiatric assessment proved that memory deficit, a slight lack of attention and minor executive dysfunction was observed a month after the patient was discharged. Although the BS-EEG pattern indicates severe brain dysfunction, it is a poor prognostic factor; rarely, patients survive with minor cognitive deficits and can perform their normal daily activities.

  7. Spatial variation in automated burst suppression detection in pharmacologically induced coma.

    Science.gov (United States)

    An, Jingzhi; Jonnalagadda, Durga; Moura, Valdery; Purdon, Patrick L; Brown, Emery N; Westover, M Brandon

    2015-01-01

    Burst suppression is actively studied as a control signal to guide anesthetic dosing in patients undergoing medically induced coma. The ability to automatically identify periods of EEG suppression and compactly summarize the depth of coma using the burst suppression probability (BSP) is crucial to effective and safe monitoring and control of medical coma. Current literature however does not explicitly account for the potential variation in burst suppression parameters across different scalp locations. In this study we analyzed standard 19-channel EEG recordings from 8 patients with refractory status epilepticus who underwent pharmacologically induced burst suppression as medical treatment for refractory seizures. We found that although burst suppression is generally considered a global phenomenon, BSP obtained using a previously validated algorithm varies systematically across different channels. A global representation of information from individual channels is proposed that takes into account the burst suppression characteristics recorded at multiple electrodes. BSP computed from this representative burst suppression pattern may be more resilient to noise and a better representation of the brain state of patients. Multichannel data integration may enhance the reliability of estimates of the depth of medical coma.

  8. Suppression of the Early Optical Afterglow of Gamma-Ray Bursts

    CERN Document Server

    Roming, P W A; Fox, D B; Zhang, B; Liang, E; Mason, K O; Rol, E; Burrows, D N; Blustin, A J; Boyd, P T; Brown, P; Holland, S T; McGowan, K; Landsman, W B; Page, K L; Rhoads, J E; Rosen, S R; Barthelmy, S D; Breeveld, A A; Cucchiara, A; De Pasquale, M; Fenimore, E E; Gehrels, N; Gronwall, C; Grupe, D; Goad, M R; Ivanushkina, M; James, C; Kennea, J A; Kobayashi, S; Mangano, V; Mészáros, P; Morgan, A N; Nousek, J A; Osborne, J P; Palmer, D M; Poole, T; Still, M D; Tagliaferri, G; Zane, S

    2005-01-01

    Recent observations of gamma-ray bursts (GRBs) are providing prompt few-arcminute gamma-ray localizations, rapid few-arcsecond X-ray positions, and rapid and extensive follow-up in the X-ray, UV, optical, and radio bands. Thirteen of these bursts include extraordinary optical upper limits at very early epochs after the burst, in marked contrast to the bright optical flashes previously believed to be the norm. Although host extinction can explain the properties of some bursts, and the natural range of burst energies and distances can explain some others, comparison of our optical, X-ray, and gamma-ray data sets reveals that these considerations alone cannot explain the full diversity of the burst population. Instead, one or more mechanisms must act to suppress the optical flash and provide a significantly enhanced efficiency of the prompt gamma-ray emission for some bursts. One possibility is that a fraction of the burst population is powered by Poynting flux-dominated outflows, resulting in a very inefficient...

  9. Video/EEG aspects of early-infantile epileptic encephalopathy with suppression-bursts (Ohtahara syndrome).

    Science.gov (United States)

    Fusco, L; Pachatz, C; Di Capua, M; Vigevano, F

    2001-11-01

    Early-infantile epileptic encephalopathy (EIEE) with suppression-bursts is a severe neonatal epileptic encephalopathy. The etiology is multiple, with cerebral malformations as the more frequent. We review the clinical and video/EEG aspects of eight infants with EIEE. These infants, aged between 4 and 70 days at the time of video/EEG recordings, were studied in relation to their clinical and video/EEG characteristics, evolution, persistence of suppression-burst pattern and etiology. Seven of the eight infants showed an ictal clinical sign correlated to the burst of the suppression-burst pattern, four of whom died within 11 months of age. The other three are alive. One, now aged 4 years, underwent surgery for hemimegalencephaly and is seizure-free, with good neurological outcome. One, now aged 9 months, was pyridoxine-dependent and she is seizure-free, and with normal neurological evolution under pyridoxine therapy. One, now aged 3 years and 9 months, is seizure-free, but with severe neurological and cognitive impairment. The only child who did not show a clinical ictal correlation of burst is also alive, now aged 3 years and 9 months, with drug-resistant epilepsy, and severe neurological and cognitive deficits. With regard to the etiology, three showed structural abnormalities, two more showed some signs of prenatal origin of neurological disease, and three had metabolic etiology. Our study confirms that EIEE is a severe age-dependent early epileptic encephalopathy. The etiology is mostly malformative. The prognosis is poor regarding motor and cognitive development, seizures, as well as life expectancies. The presence of an ictal burst of the suppression-burst pattern usually correlates with a negative outcome.

  10. Periodic Lateralized Epileptiform Discharges can Survive Anesthesia and Result in Asymmetric Drug-induced Burst Suppression

    Science.gov (United States)

    Mader, Edward C.; Cannizzaro, Louis A.; Williams, Frank J.; Lalan, Saurabh; Olejniczak, Piotr W.

    2017-01-01

    Drug-induced burst suppression (DIBS) is bihemispheric and bisymmetric in adults and older children. However, asymmetric DIBS may occur if a pathological process is affecting one hemisphere only or both hemispheres disproportionately. The usual suspect is a destructive lesion; an irritative or epileptogenic lesion is usually not invoked to explain DIBS asymmetry. We report the case of a 66-year-old woman with new-onset seizures who was found to have a hemorrhagic cavernoma and periodic lateralized epileptiform discharges (PLEDs) in the right temporal region. After levetiracetam and before anesthetic antiepileptic drugs (AEDs) were administered, the electroencephalogram (EEG) showed continuous PLEDs over the right hemisphere with maximum voltage in the posterior temporal region. Focal electrographic seizures also occurred occasionally in the same location. Propofol resulted in bihemispheric, but not in bisymmetric, DIBS. Remnants or fragments of PLEDs that survived anesthesia increased the amplitude and complexity of the bursts in the right hemisphere leading to asymmetric DIBS. Phenytoin, lacosamide, ketamine, midazolam, and topiramate were administered at various times in the course of EEG monitoring, resulting in suppression of seizures but not of PLEDs. Ketamine and midazolam reduced the rate, amplitude, and complexity of PLEDs but only after producing substantial attenuation of all burst components. When all anesthetics were discontinued, the EEG reverted to the original preanesthesia pattern with continuous non-fragmented PLEDs. The fact that PLEDs can survive anesthesia and affect DIBS symmetry is a testament to the robustness of the neurodynamic processes underlying PLEDs. PMID:28286626

  11. Simultaneous application of slow-oscillation transcranial direct current stimulation and theta burst stimulation prolongs continuous theta burst stimulation-induced suppression of corticomotor excitability in humans.

    Science.gov (United States)

    Doeltgen, Sebastian H; McAllister, Suzanne M; Ridding, Michael C

    2012-09-01

    The objective of this study was to assess whether the simultaneous application of slow-oscillation transcranial direct current stimulation enhances the neuroplastic response to transcranial magnetic theta burst stimulation. Motor evoked potential amplitude was assessed at baseline and at regular intervals up to 60 min following continuous theta burst stimulation, slow-oscillation transcranial direct current stimulation, and the simultaneous application of these paradigms. In addition, the electroencephalographic power spectra of slow and fast delta, and theta frequency bands recorded over the motor cortex were analyzed prior to and up to 5 min following each intervention. There was longer-lasting motor evoked potential suppression following the simultaneous application of continuous theta burst stimulation and slow-oscillation transcranial direct current stimulation compared with when continuous theta burst stimulation was applied alone. Slow-oscillation transcranial direct current stimulation applied alone did not modulate the motor evoked potential amplitude. No significant changes in spectral power were observed following slow-oscillation transcranial direct current stimulation. Simultaneous application of continuous theta burst stimulation and slow-oscillation transcranial direct current stimulation may provide an approach to prolong the induction of neuroplastic changes in motor cortical circuits by repetitive transcranial magnetic brain stimulation.

  12. Entropy of the EEG in transition to burst suppression in deep anesthesia: Surrogate analysis.

    Science.gov (United States)

    Anier, Andres; Lipping, Tarmo; Jantti, Ville; Puumala, Pasi; Huotari, Ari-Matti

    2010-01-01

    In this paper 5 methods for the assessment of signal entropy are compared in their capability to follow the changes in the EEG signal during transition from continuous EEG to burst suppression in deep anesthesia. To study the sensitivity of the measures to phase information in the signal, phase randomization as well as amplitude adjusted surrogates are also analyzed. We show that the selection of algorithm parameters and the use of normalization are important issues in interpretation and comparison of the results. We also show that permutation entropy is the most sensitive to phase information among the studied measures and that the EEG signal during high amplitude delta activity in deep anesthesia is of highly nonlinear nature.

  13. Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus.

    Science.gov (United States)

    Kang, Bong Su; Jung, Keun-Hwa; Shin, Jeong-Won; Moon, Jang Sup; Byun, Jung-Ick; Lim, Jung-Ah; Moon, Hye Jin; Kim, Young-Soo; Lee, Soon-Tae; Chu, Kon; Lee, Sang Kun

    2015-05-01

    General anesthetic-induced coma therapy has been recommended for the treatment of refractory status epilepticus (RSE). However, the influence of electroencephalographic (EEG) burst suppression (BS) on outcomes still remains unclear. This study investigated the impact of intravenous anesthetic-induced BS on the prognosis of RSE using a retrospective analysis of all consecutive adult patients who received intravenous anesthetic treatment for RSE at the Seoul National University Hospital between January 2006 and June 2011. Twenty-two of the 111 episodes of RSE were enrolled in this study. Of the 22 RSE patients, 12 (54.5%) were women and 18 (81.4%) exhibited generalized convulsive status epilepticus. Sixteen patients (72.7%) were classified as having acute symptomatic etiology, including three patients with anoxic encephalopathy, and others with remote symptomatic etiology. Only two patients (9.1%) had a favorable Status Epilepticus Severity Score (0-2) at admission. All patients received midazolam (MDZ) as a primary intravenous anesthetic drug for RSE treatment; three (13.6%) received MDZ and propofol, and one (4.5%) received MDZ and pentobarbital. The rates of mortality and poor outcome at discharge were 13.6% (n=3) and 54.5% (n=12), respectively. While BS was achieved in six (27.5%) patients, it was not associated with mortality or poor outcome. Induced BS was associated with prolonged hospital stay in subgroup analysis when excluding anoxic encephalopathy. Our results suggest that induction of BS for treating RSE did not affect mortality or outcome at discharge and may lead to an increased length of hospital stay.

  14. Interleukin-10 inhibits burst-forming unit-erythroid growth by suppression of endogenous granulocyte-macrophage colony-stimulating factor production from T cells.

    Science.gov (United States)

    Oehler, L; Kollars, M; Bohle, B; Berer, A; Reiter, E; Lechner, K; Geissler, K

    1999-02-01

    Numerous cytokines released from accessory cells have been shown to exert either stimulatory or inhibitory growth signals on burst-forming unit-erythroid (BFU-E) growth. Because of its cytokine synthesis-inhibiting effects on T cells and monocytes, interleukin-10 (IL-10) may be a potential candidate for indirectly affecting erythropoiesis. We investigated the effects of IL-10 on BFU-E growth from normal human peripheral blood mononuclear cells (PBMC) using a clonogenic progenitor cell assay. The addition of recombinant human IL-10 to cultures containing recombinant human erythropoietin suppressed BFU-E growth in a dose-dependent manner (by 55.2%, range 47.3-63.3%, p cultivating highly enriched CD34+ cells. BFU-E growth from PBMC also was markedly suppressed in the presence of a neutralizing anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody (by 48.7%, range 32.9-61.2% inhibition,p < 0.01), but not by neutralizing antibodies against granulocyte colony-stimulating factor and interleukin-3. This suggests a stimulatory role of endogenously released GM-CSF on BFU-E formation. Also, the addition of exogenous GM-CSF completely restored IL-10-induced suppression of BFU-E growth. To determine the cellular source of GM-CSF production, we analyzed GM-CSF levels in suspension cultures containing PBMC that were either depleted of monocytes or T cells. Monocyte-depleted PBMC showed spontaneous production of increasing amounts of GM-CSF on days 3, 5, and 7, respectively, which could be suppressed by IL-10, whereas GM-CSF levels did not increase in cultures containing T-cell-depleted PBMC. Our data indicate that IL-10 inhibits the growth of erythroid progenitor cells in vitro, most likely by suppression of endogenous GM-CSF production from T cells.

  15. Suitable level of suppression in Pinus sylvestris

    Energy Technology Data Exchange (ETDEWEB)

    Hagner, Mats

    1999-10-01

    It is `well known` among Swedish foresters that pine trees need light and cannot grow suppressed. It is also `well known` that old trees that have grown slowly are unable to react with good growth. However, these facts can be questioned in the light of new research as it has been found that thinning reaction is not correlated with age. It is also well known that the commercial value of a pine is closely related to the growth at young age. If the first 20 annual rings close to pith are wide (>3 mm) the log cannot be accepted as first class. This is related to number and size of branches on the young tree and to the features of the juvenile wood. This is to say that a pine must not grow fast when it is small and if this has happened it cannot be cured by artificial debranching or by growing the tree slowly at higher age. Accordingly, young pines should be grown under bigger trees that in their young age were grown under big trees, and so on. Today, when clear cutting is the dominating forest management system, the only way to obtain high quality pine trees is to start the rotation age with stands of very high density. This is of course a very expensive way as dense planting, followed by intensive thinning requires a lot of input. However, if pine is a pioneer species and cannot be grown in multistoried stands, then the economic solution is not present. This was the reason why the annual increment of three pines was measured. They were selected because their different growth pattern showed that old `well known facts` should be revised Working papers 139. 3 refs, 7 figs, 1 tab

  16. Vanillin suppresses Kupffer cell-related colloidal carbon-induced respiratory burst activity in isolated perfused rat liver: anti-inflammatory implications.

    Science.gov (United States)

    Galgani, José E; Núñez, Bárbara; Videla, Luis A

    2012-12-01

    The inhibition of NADPH oxidase has become a potential therapeutic target for oxidative stress-related diseases. We investigated whether vanillin modifies hepatic O(2) consumption associated with Kupffer cell functioning. The influence of vanillin on Kupffer cell functioning was studied in isolated perfused rat liver by colloidal carbon (CC) infusion (0.5 mg ml(-1)), concomitantly with sinusoidal efflux of lactate dehydrogenase (LDH) as an organ viability parameter. CC infusion increased the rate of O(2) consumption of the liver above basal values, an effect that represents the respiratory burst activity of Kupffer cells. However, CC-dependent respiratory burst activity was suppressed by previous infusion of 2 mM vanillin. Vanillin did not affect the liver CC uptake rate and liver sinusoidal efflux of LDH efflux. These findings, elicited by vanillin, were reproduced by the well-established NADPH oxidase inhibitor apocynin. In conclusion, vanillin suppresses the respiratory burst activity of Kupffer cells as assessed in intact liver, which may be associated with the inhibition of macrophage NADPH oxidase activity. Such a finding may have relevance in conditions underlying Kupffer cell-dependent up-regulation of the expression and release of pro-inflammatory mediators by redox-dependent mechanisms.

  17. 麻醉剂浓度对大鼠暴发-抑制脑电特征的影响%The Effect of Anesthetic Concentration on Burst-suppression of the EEG in Rats

    Institute of Scientific and Technical Information of China (English)

    张丹丹; 贾晓枫; 丁海艳

    2012-01-01

    The term "burst-suppression" is used to describe the electroencephalogram (EEG) pattern characterized by 0 or d waves, at times intermixed with faster waves, and intervening periods of relative quiescence. Burst-suppression pattern can reflect the seriously suppressed brain activity under deep anesthesia. To investigate the relationship between burst-suppression features and anesthetic concentration, we adopted four straightforward indexes, i. e. , burst-suppression ratio (BSR). burst frequency, burst amplitude and suppression amplitude, and used them to analyze the EEG recordings in ten isoflurane-anesthetized rats. It was found that all the four burst-suppression indexes changed along with anesthetic concentration, that BSR and burst amplitude increased with higher concentration of isoflurane while burst frequency and suppression amplitude decreased, and that BSR was the most sensitive and consistent measurement to indicate isoflurane concentration so it constituted a valuable tool for timely evaluation of burst-suppression feature under deep anesthesia. The result also showed that the composition of carrier gas (i. e. pure oxygen vs. mixed oxygen) did not influence the effect of anesthesia significantly;and the four indexes of burst-suppression features could keep relatively stable within 60min under the isoflurane concentration of 2%. The present study provides quantitative information of burst-suppression features under different anesthetic depth and may help to develop a clinically satisfied system that could quantify the characteristics of EEG and rigorously evaluate the cerebral state of patients.%暴发-抑制脑电图(EEG)是深度麻醉状态下EEG活动受到严重抑制的表现.为定量研究暴发-抑制波形特征与麻醉剂浓度之间的关系,本文采用暴发-抑制比、暴发频率、暴发幅度和抑制幅度4个时域指标,分析大鼠麻醉模型在不同异氟烷浓度下的EEG特征.结果表明,暴发-抑制脑电的4个指标均

  18. Observation of gamma ray bursts at ground level under the thunderclouds

    Science.gov (United States)

    Kuroda, Y.; Oguri, S.; Kato, Y.; Nakata, R.; Inoue, Y.; Ito, C.; Minowa, M.

    2016-07-01

    We observed three γ-ray bursts related to thunderclouds in winter using the prototype of anti-neutrino detector PANDA made of 360-kg plastic scintillator deployed at Ohi Power Station at the coastal area of the Japan Sea. The maximum rate of the events which deposited the energy higher than 3 MeV was (5.5 ± 0.1) ×102 /s. Monte Carlo simulation showed that electrons with approximately monochromatic energy falling downwards from altitudes of order 100 m roughly produced the observed total energy spectra of the bursts. It is supposed that secondary cosmic-ray electrons, which act as seed, were accelerated in electric field of thunderclouds and multiplied by relativistic runaway electron avalanche. We actually found that the γ-rays of the bursts entered into the detector from the direction close to the zenith. The direction stayed constant during the burst within the detector resolution. In addition, taking advantage of the delayed coincidence detection of the detector, we found neutron events in one of the bursts at the maximum rate of ∼ 14 ± 5 /s.

  19. Observation of gamma ray bursts at ground level under the thunderclouds

    CERN Document Server

    Kuroda, Y; Kato, Y; Nakata, R; Inoue, Y; Ito, C; Minowa, M

    2016-01-01

    We observed three $\\gamma$-ray bursts related to thunderclouds in winter using the prototype of anti-neutrino detector PANDA made of 360-kg plastic scintillator deployed at Ohi Power Station at the coastal area of the Japan Sea. The maximum rate of the events which deposited the energy higher than 3 MeV was $(5.5 \\pm 0.1) \\times 10^2 {\\rm /s}$. Monte Carlo simulation showed that the observed total energy spectra of the bursts are well described by the bremsstrahlung $\\gamma$-rays by electrons with approximately monochromatic energy falling downwards from altitudes of order $100\\,$m. It is supposed that secondary cosmic-ray electrons, which act as seed, were accelerated in electric field of thunderclouds and multiplied by relativistic runaway electron avalanche. We actually found that the $\\gamma$-rays of the bursts entered into the detector from the direction close to the zenith. The direction stayed constant during the burst within the detector resolution. In addition, taking advantage of the delayed coincid...

  20. Canyon of current suppression in an interacting two-level quantum dot

    DEFF Research Database (Denmark)

    Karlström, O; Pedersen, Jonas Nyvold; Samuelsson, P

    2011-01-01

    Motivated by the recent discovery of a canyon of conductance suppression in a two-level equal-spin quantum dot system [Phys. Rev. Lett. 104, 186804 (2010)], the transport through this system is studied in detail. At low bias and low temperature a strong current suppression is found around...

  1. 58 mJ burst comprising ultrashort pulses with homogenous energy level from an Yb-doped fiber amplifier.

    Science.gov (United States)

    Breitkopf, Sven; Klenke, Arno; Gottschall, Thomas; Otto, Hans-Jürgen; Jauregui, Cesar; Limpert, Jens; Tünnermann, Andreas

    2012-12-15

    We report on a laser system producing a burst comprising femtosecond pulses with a total energy of 58 mJ. Every single pulse within this burst has an energy between 27 and 31 μJ. The pump is able to rebuild the inversion fast enough between the pulses, resulting in an almost constant gain for every pulse during the burst. This causes a very homogenous energy distribution during the burst. The output burst has a repetition frequency of 20 Hz, is 200 μs long and, therefore, contains 2000 pulses at a pulse repetition rate of 10 MHz.

  2. Polarization enhancement and suppression of four-wave mixing in multi-Zeeman levels

    Institute of Scientific and Technical Information of China (English)

    Zhiguo Wang; Yuxin Fu; Yue Song; Guoxian Dai; Feng Wen; Jinyan Zhao; Yanpeng Zhang

    2011-01-01

    Polarization dependence of the enhancement and suppression of four-wave mixing(FWM) in a multiZeeman level atomic system is investigated both theoretically and experimentally.A dressing field applied to the adjacent transition can cause energy level splitting.Therefore,it can control the enhancement and suppression of the FWM processes in the system due to the effect of electromagnetically induced transparency.The results show that the pumping beams with different polarizations select the transitions between different Zeeman levels that,in turn,affect the enhancement and suppression efficiencies of FWM.

  3. Magnetar Bursts

    Science.gov (United States)

    Kouveliotou, Chryssa

    2014-01-01

    The Fermi/Gamma-ray Burst Monitor (GBM) was launched in June 2008. During the last five years the instrument has observed several hundreds of bursts from 8 confirmed magnetars and 19 events from unconfirmed sources. I will discuss the results of the GBM magnetar burst catalog, expand on the different properties of their diverse source population, and compare these results with the bursting activity of past sources. I will then conclude with thoughts of how these properties fit the magnetar theoretical models.

  4. The Impact of Promoting Transcription on Early Text Production: Effects on Bursts and Pauses, Levels of Written Language, and Writing Performance

    Science.gov (United States)

    Alves, Rui A.; Limpo, Teresa; Fidalgo, Raquel; Carvalhais, Lénia; Pereira, Luísa Álvares; Castro, São Luís

    2016-01-01

    Writing development seems heavily dependent upon the automatization of transcription. This study aimed to further investigate the link between transcription and writing by examining the effects of promoting handwriting and spelling skills on a comprehensive set of writing measures (viz., bursts and pauses, levels of written language, and writing…

  5. Research on Acceleration Disturbance Suppression for Dynamic Detection of Level Attitude

    Science.gov (United States)

    Tan, Linxia; Zhang, Fuxue

    The paper presents a new method to eliminate acceleration disturbance in level attitude measurement and control of moving carrier. Output signals of micro-machined inclinometer and gyroscope are analyzed in different states of moving carrier by experimental simulation, results show that gyroscope almost keeps the zero output voltage while inclinometer outputs in significant fluctuations. With the analysis results, a new method on acceleration disturbance suppression is developed base on a combination of inclinometers and gyroscopes, which includes establishment and derivation of its mathematical model and implementation, and an algorithm software design. Finally, tests to the acceleration disturbance suppression effect are demonstrated in line motion, line vibration, angular motion and angular motion plus pitch swing. Experimental results show that the method achieves its expected effect. The inertial system constitutes of inclinometers and gyros interacting with acceleration disturbance suppression method can dynamic detect the level attitude of moving carrier.

  6. Ventilation rates and activity levels of juvenile jumbo squid under metabolic suppression in the oxygen minimum zone.

    Science.gov (United States)

    Trübenbach, Katja; Pegado, Maria R; Seibel, Brad A; Rosa, Rui

    2013-02-01

    The Humboldt (jumbo) squid, Dosidicus gigas, is a part-time resident of the permanent oxygen minimum zone (OMZ) in the Eastern Tropical Pacific and, thereby, it encounters oxygen levels below its critical oxygen partial pressure. To better understand the ventilatory mechanisms that accompany the process of metabolic suppression in these top oceanic predators, we exposed juvenile D. gigas to the oxygen levels found in the OMZ (1% O(2), 1 kPa, 10 °C) and measured metabolic rate, activity cycling patterns, swimming mode, escape jet (burst) frequency, mantle contraction frequency and strength, stroke volume and oxygen extraction efficiency. In normoxia, metabolic rate varied between 14 and 29 μmol O(2) g(-1) wet mass h(-1), depending on the level of activity. The mantle contraction frequency and strength were linearly correlated and increased significantly with activity level. Additionally, an increase in stroke volume and ventilatory volume per minute was observed, followed by a mantle hyperinflation process during high activity periods. Squid metabolic rate dropped more than 75% during exposure to hypoxia. Maximum metabolic rate was not achieved under such conditions and the metabolic scope was significantly decreased. Hypoxia changed the relationship between mantle contraction strength and frequency from linear to polynomial with increasing activity, indicating that, under hypoxic conditions, the jumbo squid primarily increases the strength of mantle contraction and does not regulate its frequency. Under hypoxia, jumbo squid also showed a larger inflation period (reduced contraction frequency) and decreased relaxed mantle diameter (shortened diffusion pathway), which optimize oxygen extraction efficiency (up to 82%/34%, without/with consideration of 60% potential skin respiration). Additionally, they breathe 'deeply', with more powerful contractions and enhanced stroke volume. This deep-breathing behavior allows them to display a stable ventilatory volume per

  7. Cross-Circulating Current Suppression Method for Parallel Three-Phase Two-Level Inverters

    DEFF Research Database (Denmark)

    Wei, Baoze; Guerrero, Josep M.; Guo, Xiaoqiang

    2015-01-01

    The parallel architecture is very popular for power inverters to increase the power level. This paper presents a method for the parallel operation of inverters in an ac-distributed system, to suppress the cross-circulating current based on virtual impedance without current-sharing bus...

  8. Is suppression of bone formation during simulated weightlessness related to glucocorticoid levels

    Science.gov (United States)

    Morey-Holton, E. R.; Bomalaski, M. D.; Enayati-Gordon, E.; Gonsalves, M. R.; Wronski, T. J.

    1982-01-01

    To investigate the hypothesis that suppression of bone formation in the suspended rat model was the result of increased levels of corticosterone, experiments were performed on young, growing, male rats exposed either to 4 C or suspended for two weeks. Rats suspended on the model system, designed to simulate certain aspects of spaceflight, gained weight at a rate at least equal to control animals but still showed a significant suppression of bone formation within 7 days. Cold-exposed rats gained less weight than their corresponding control group and did not demonstrate any suppression of bone formation. These findings suggest: (1) tail suspension is less stressful than previously used harness systems; (2) suspension in young, rapidly growing rats causes a significant suppression of cortical bone formation; (3) cold exposure does not alter bone formation rate in rats of a similar age and strain to those suspended in this study; and (4) suppression of bone formation provoked by unloading the rear limbs is not due solely to sustained stimulation of the pituitary-adrenal system.

  9. Ceruloplasmin decreases respiratory burst reaction during pregnancy.

    Science.gov (United States)

    Varfolomeeva, Elena Y; Semenova, Elena V; Sokolov, Alexey V; Aplin, Kirill D; Timofeeva, Kseniya E; Vasilyev, Vadim B; Filatov, Michael V

    2016-08-01

    Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pregnant women have not been detected so far. At the same time, concentration of ceruloplasmin - a copper-containing glycoprotein - is known to increase in blood significantly during pregnancy. We observed the negative correlation between ceruloplasmin concentration in blood plasma of pregnant women and the intensity of respiratory burst of neutrophils. Fractionation of plasma using gel-filtration revealed that ceruloplasmin-containing fraction demonstrated suppression of the respiratory burst reaction. Partial elimination of ceruloplasmin from the blood of pregnant women, performed with the help of specific antibodies and followed by immunoprecipitation, leads to an increased respiratory burst reaction. On the contrary, addition of ceruloplasmin to blood samples of healthy donors noticeably decreases the respiratory burst reaction. The results presented prove that change in ceruloplasmin level in plasma is necessary and sufficient for modulating the ability of neutrophils to produce reactive oxygen species during pregnancy.

  10. Caffeine suppresses β-amyloid levels in plasma and brain of Alzheimer’s transgenic mice

    OpenAIRE

    Cao, Chuanhai; Cirrito, John R.; Lin, Xiaoyang; Wang, Lilly; Verges, Deborah K.; Dickson, Alexander; Mamcarz, Malgorzata; Zhang, Chi; Mori, Takashi; Arendash, Gary W.; Holtzman, David M.; Potter, Huntington

    2009-01-01

    Recent epidemiologic studies suggest that caffeine may be protective against Alzheimer’s Disease (AD). Supportive of this premise, our previous studies have shown that moderate caffeine administration protects/restores cognitive function and suppresses brain β-amyloid (Aβ) production in AD transgenic mice. In the present study, we report that acute caffeine administration to both young adult and aged AD transgenic mice rapidly reduces Aβ levels in both brain interstitial fluid and plasma with...

  11. Agroinfiltration reduces ABA levels and suppresses Pseudomonas syringae-elicited salicylic acid production in Nicotiana tabacum.

    Directory of Open Access Journals (Sweden)

    Arantza Rico

    Full Text Available BACKGROUND: Agrobacterium tumefaciens strain GV3101 (pMP90 is widely used in transient gene expression assays, including assays to study pathogen effectors and plant disease resistance mechanisms. However, inoculation of A. tumefaciens GV3101 into Nicotiana tabacum (tobacco leaves prior to infiltration with pathogenic and non-host strains of Pseudomonas syringae results in suppression of macroscopic symptoms when compared with leaves pre-treated with a buffer control. METHODOLOGY/FINDINGS: To gain further insight into the mechanistic basis of symptom suppression by A. tumefaciens we examined the effect of pre-treatment with A. tumefaciens on the growth of P. syringae, the production of the plant signalling molecules salicylic acid (SA and abscisic acid (ABA, and the presence of callose deposits. Pre-treatment with A. tumefaciens reduced ABA levels, P. syringae multiplication and P. syringae-elicited SA and ABA production, but promoted increased callose deposition. However, pre-treatment with A. tumefaciens did not suppress necrosis or SA production in leaves inoculated with the elicitor HrpZ. CONCLUSIONS/SIGNIFICANCE: Collectively, these results show that inoculation of N. tabacum leaves with A. tumefaciens alters plant hormone levels and plant defence responses to P. syringae, and demonstrate that researchers should consider the impact of A. tumefaciens on plant signal transduction when using A. tumefaciens-mediated transient expression assays to investigate ABA-regulated processes or pathogenicity and plant defence mechanisms.

  12. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.

    Science.gov (United States)

    Cao, Chuanhai; Cirrito, John R; Lin, Xiaoyang; Wang, Li; Wang, Lilly; Verges, Deborah K; Dickson, Alexander; Mamcarz, Malgorzata; Zhang, Chi; Mori, Takashi; Arendash, Gary W; Holtzman, David M; Potter, Huntington

    2009-01-01

    Recent epidemiologic studies suggest that caffeine may be protective against Alzheimer's disease (AD). Supportive of this premise, our previous studies have shown that moderate caffeine administration protects/restores cognitive function and suppresses brain amyloid-beta (Abeta) production in AD transgenic mice. In the present study, we report that acute caffeine administration to both young adult and aged AD transgenic mice rapidly reduces Abeta levels in both brain interstitial fluid and plasma without affecting Abeta elimination. Long-term oral caffeine treatment to aged AD mice provided not only sustained reductions in plasma Abeta, but also decreases in both soluble and deposited Abeta in hippocampus and cortex. Irrespective of caffeine treatment, plasma Abeta levels did not correlate with brain Abeta levels or with cognitive performance in individual aged AD mice. Although higher plasma caffeine levels were strongly associated with lower plasma Abeta1-40 levels in aged AD mice, plasma caffeine levels were also not linked to cognitive performance. Plasma caffeine and theophylline levels were tightly correlated, both being associated with reduced inflammatory cytokine levels in hippocampus. Our conclusion is two-fold: first, that both plasma and brain Abeta levels are reduced by acute or chronic caffeine administration in several AD transgenic lines and ages, indicating a therapeutic value of caffeine against AD; and second, that plasma Abeta levels are not an accurate index of brain Abeta levels/deposition or cognitive performance in aged AD mice.

  13. Short Segment Fixation Versus Short Segment Fixation With Pedicle Screws at the Fracture Level for Thoracolumbar Burst Fracture

    Directory of Open Access Journals (Sweden)

    Anghel S

    2014-04-01

    Full Text Available Objective: The most prevailing surgical procedure in the treatment of thoracolumbar burst fractures, Short Segment Fixation (SSF, is often followed by loss of correction or hardware failure which may be significant enough to require another surgical intervention. In order to take advantage of its benefits but to avoid or diminish the risk and impact of associated drawbacks, some other alternatives have been lately developed among which we refer to short segment fixation with intermediate screws (SSF+IS. This article provides a comparative picture over the effectiveness of the two above-mentioned surgical treatments, focusing on their potential to prevent the loss of correction.

  14. Suppression of Shubnikov–de Haas resistance oscillations due to selective population or detection of Landau levels : Absence of inter-Landau-level scattering on macroscopic length scales

    NARCIS (Netherlands)

    Wees, B.J. van; Willems, E.M.M.; Kouwenhoven, L.P.; Harmans, C.J.P.M.; Williamson, J.G.; Foxon, C.T.; Harris, J.J.

    1989-01-01

    The Shubnikov–de Haas resistance oscillations of a wide two-dimensional electron gas are suppressed dramatically when current is injected with a quantum point contact which does not populate the upper Landau level. A similar suppression is observed when a quantum point contact is used as a voltage p

  15. Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

    Directory of Open Access Journals (Sweden)

    Tsai Tzu-Hsien

    2012-07-01

    Full Text Available Abstract Background and aim This study tested the hypothesis that obesity suppresses circulating number as well as the function of endothelial progenitor cells (EPCs and left ventricular ejection fraction (LVEF. Methods High fat diet (45 Kcal% fat was given to 8-week-old C57BL/6 J mice (n = 8 for 20 weeks to induce obesity (group 1. Another age-matched group (n = 8 were fed with control diet for 20 weeks as controls (group 2. The animals were sacrificed at the end of 20 weeks after obesity induction. Results By the end of study period, the heart weight, body weight, abdominal fat weight, serum levels of total cholesterol and fasting blood sugar were remarkably higher in group 1 than in group 2 (all p Conclusions Obesity diminished circulating EPC level, impaired the recovery of damaged endothelium, suppressed EPC angiogenesis ability and LVEF, and increased LV remodeling.

  16. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst

    Indian Academy of Sciences (India)

    David Alan Thompson; Bruce D Hammock

    2007-03-01

    The leukotoxins [9(10)- and 12(13)-EpOME] are produced by activated inflammatory leukocytes such as neutrophils. High EpOME levels are observed in disorders such as acute respiratory distress syndrome and in patients with extensive burns. Although the physiological significance of the EpOMEs remains poorly understood, in some systems, the EpOMEs act as a protoxin, with their corresponding epoxide hydrolase metabolites, 9,10- and 12,13-DiHOME, specifically exerting toxicity. Both the EpOMEs and the DiHOMEs were also recently shown to have neutrophil chemotactic activity. We evaluated whether the neutrophil respiratory burst, a surge of oxidant production thought to play an important role in limiting certain bacterial and fungal infections, is modulated by members of the EpOME metabolic pathway. We present evidence that the DiHOMEs suppress the neutrophil respiratory burst by a mechanism distinct from that of respiratory burst inhibitors such as cyclosporin H or lipoxin A4, which inhibit multiple aspects of neutrophil activation.

  17. LPS infusion suppresses serum FGF21 levels in healthy adult volunteers

    DEFF Research Database (Denmark)

    Lauritzen, Esben Stistrup; Rittig, Nikolaj; Bach, Ermina

    2017-01-01

    CONTEXT: During the inflammatory acute phase response plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid reducing actions, but its role in the acute inflammatory response in human is unknown. OBJECTIVE: To investigate...... circulating levels of FGF21 after lipopolysaccharide (LPS) infusion. DESIGN: Two randomized, single blinded, placebo-controlled crossover trials were used. SETTING: The studies were performed at a university hospital clinical research center. PATIENTS AND INTERVENTIONS: Study 1 (LPS bolus): Eight young......) during continuously LPS infusion (0.06 ng/kg/h). Each study day lasted 4 hours. Circulating FGF21 levels were quantified every second hour by an immunoassay. RESULTS: A LPS bolus resulted in a late suppression (t = 240 minutes) of serum FGF21 (P=0.035). Continuous LPS infusion revealed no significant...

  18. Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels.

    Science.gov (United States)

    Yang, B; Yao, D F; Ohuchi, M; Ide, M; Yano, M; Okumura, Y; Kido, H

    2002-05-01

    The protective effect of ambroxol, a mucolytic agent which has antioxidant properties and stimulates the release of pulmonary surfactant, against influenza-virus proliferation in the airway was investigated in mice. Ambroxol or the vehicle was administered intraperitoneally twice a day for 5-7 days to mice shortly after intranasal infection with a lethal dose of influenza A/Aichi/68 (H3N2) virus, and the survival rate, virus titre and levels of factors regulating virus proliferation in the airway fluid were analysed. Ambroxol significantly suppressed virus multiplication and improved the survival rate of mice. The effect of ambroxol reached a peak at 10 mg x kg(-1) x day(-1), higher doses being less effective. Ambroxol stimulated the release of suppressors of influenza-virus multiplication, such as pulmonary surfactant, mucus protease inhibitor, immunoglobulin (Ig)-A and IgG, although it stimulated the release of a trypsin-type protease that potentiates virus proliferation. In addition, ambroxol transiently suppressed release of the cytokines, tumour necrosis factor-alpha, interferon-gamma and interleukin-12, into airway fluid. Although ambroxol had several negative effects on the host defence system, overall it strikingly increased the concentrations of suppressors of influenza-virus multiplication in the airway.

  19. LPS infusion suppresses serum FGF21 levels in healthy adult volunteers

    Science.gov (United States)

    Rittig, Nikolaj; Bach, Ermina; Møller, Niels; Bjerre, Mette

    2017-01-01

    Context During the inflammatory acute phase response, plasma glucose and serum triglycerides are increased in humans. Fibroblast growth factor (FGF) 21 has plasma glucose and lipid-reducing actions, but its role in the acute inflammatory response in human is unknown. Objective To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion. Design Two randomized, single-blinded, placebo-controlled crossover trials were used. Setting The studies were performed at a university hospital clinical research center. Patients and interventions Study 1 (LPS bolus): Eight young, healthy, lean males were investigated two times: (1) after isotonic saline injection and (2) after LPS injection (bolus of 1 ng/kg). Each study day lasted 4 h. Study 2 (continuous LPS infusion): Eight, healthy males were investigated two times: (1) during continuously isotonic saline infusion and (2) during continuous LPS infusion (0.06 ng/kg/h). Each study day lasted 4 h. Circulating FGF21 levels were quantified every second hour by an immunoassay. Results A LPS bolus resulted in a late suppression (t = 240 min) of serum FGF21 (P = 0.035). Continuous LPS infusion revealed no significant effects on FGF21 levels (P = 0.82). Conclusions Our studies show that a bolus of LPS results in decreased FGF21 levels 4 h from exposure. PMID:28069899

  20. Effects of estradiol and FSH on leptin levels in women with suppressed pituitary

    Directory of Open Access Journals (Sweden)

    Geber Selmo

    2012-06-01

    Full Text Available Abstract Background Female fertility depends on adequate nutrition and energy reserves, suggesting a correlation between the metabolic reserve and reproductive capacity. Leptin regulates body weight and energy homeostasis. The aim of this study was to investigate whether estradiol or FSH alone has a direct effect on the production of leptin. Methods A total of 64 patients submitted to controlled ovarian hyperstimulation with recombinant FSH for assisted reproduction and 20 patients using estradiol valerate for endometrial preparation for oocyte donation treatment were included in the study. All patients used GnRH analogues before starting treatment to achieve pituitary suppression. Blood samples for hormonal measurements were collected before starting and after completing the respective treatments. Data were analyzed statistically by the chi-square test, Student’s t-test and Pearson’s correlation test. Results We observed an elevation of serum leptin levels secondary to the increase in estradiol, in the absence of influence of any other ovarian or pituitary hormone. The rising rate of leptin levels was higher in women treated with recombinant FSH, which also had higher levels of estradiol, than in those treated with estradiol valerate. Conclusions This study demonstrates a correlation between serum levels of estradiol and leptin, suggesting that estradiol is an important regulator of leptin production and that its effects can be amplified by its association with FSH.

  1. Concept for LEU Burst Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Steven Karl [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kimpland, Robert Herbert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-07

    Design and performance of a proposed LEU burst reactor are sketched. Salient conclusions reached are the following: size would be ~1,500 kg or greater, depending on the size of the central cavity; internal stresses during burst require split rings for relief; the reactor would likely require multiple control and safety rods for fine control; the energy spectrum would be comparable to that of HEU machines; and burst yields and steady-state power levels will be significantly greater in an LEU reactor.

  2. Melamine Impairs Female Fertility via Suppressing Protein Level of Juno in Mouse Eggs.

    Science.gov (United States)

    Dai, Xiaoxin; Zhang, Mianqun; Lu, Yajuan; Miao, Yilong; Zhou, Changyin; Sun, Shaochen; Xiong, Bo

    2015-01-01

    Melamine is an organic nitrogenous compound widely used as an industrial chemical, and it has been recently reported by us that melamine has a toxic effect on the female reproductive system in mice, and renders females subfertile; the molecular basis, however, has not been adequately assessed. In the present study, we explore the underlying mechanism regarding how melamine compromises fertility in the mouse. The data showed that melamine exposure significantly impaired the fertilization capability of the egg during in vitro fertilization. To further figure out the cause, we analyzed ovastacin localization and protein level, the sperm binding ability of zona pellucida, and ZP2 cleavage status in unfertilized eggs from melamine fed mice, and no obvious differences were found between control and treatment groups. However, the protein level of Juno on the egg plasma membrane in the high-dose feeding group indeed significantly decreased compared to the control group. Thus, these data suggest that melamine compromises female fertility via suppressing Juno protein level on the egg membrane.

  3. Transcriptional burst frequency and burst size are equally modulated across the human genome

    Energy Technology Data Exchange (ETDEWEB)

    Dar, Roy D. [University of Tennessee, Knoxville (UTK); Simpson, Michael L [ORNL; Weinberger, Leor S. [University of California, San Diego; Razooky, B [University of California, San Diego; Cox, Chris D. [University of Tennessee, Knoxville (UTK); McCollum, James M. [Miami University; Trimeloni, Tom [Virginia Commonwealth University, Richland; Singh, A [University of California, San Diego

    2012-01-01

    Gene expression occurs either as an episodic process, characterized by pulsatile bursts or as a constitutive, Poisson-like accumulation of gene products. It is not clear which mode of gene expression (constitutive versus bursty) predominates across a genome or how transcriptional dynamics are influenced by genomic position and promoter sequence. Here, we use time-lapse fluorescence microscopy, building off of theoretical studies that exploit the time-resolved structure of stochastic fluctuations in gene expression, to develop a three-dimensional method for mapping underlying gene-regulatory mechanisms. Over 8,000 individual human genomic loci were analyzed, and at virtually all loci, episodic bursting as opposed to constitutive expression was found to be the predominant mode of expression. Quantitative analysis of the expression dynamics at these 8,000 loci indicates that both frequency and size of transcriptional bursts vary equally across the human genome independent of promoter sequence. Strikingly, weaker expression loci modulate burst frequency to increase activity, while stronger expression loci modulate burst size to increase activity. Transcriptional activators, such as TNF, generate similar patterns of change in burst frequency and burst size. In summary, transcriptional bursting dominates across the human genome, both burst frequency and burst size vary by chromosomal location, and transcriptional activators alter burst frequency and burst size, depending on the expression level of the locus.

  4. Disinhibition Bursting of Dopaminergic Neurons

    Directory of Open Access Journals (Sweden)

    Collin J Lobb

    2011-05-01

    Full Text Available Substantia nigra pars compacta (SNpc dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr and globus pallidus (GP, and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in dopaminergic neurons. We first applied constant NMDA and GABAA conductances onto a two-compartment single cell model of the dopaminergic neuron (Kuznetsov et al., 2006. The model exhibited disinhibition bursting upon stepwise removal of inhibition. A further bifurcation analysis suggests that disinhibition may be more robust than excitation alone in that for most levels of NMDA conductance, the cell remains capable of bursting even after a complete removal of inhibition, whereas too much excitatory input will drive the cell into depolarization block. To investigate the network dynamics of disinhibition, we used a modified version of an integrate-and-fire based model of the basal ganglia (Humphries et al., 2006. Synaptic activity generated in the network was delivered to the two-compartment single cell dopaminergic neuron. Phasic activation of the D1-expressing medium spiny neurons in the striatum (D1STR produced disinhibition bursts in dopaminergic neurons through the direct pathway (D1STR to SNpr to SNpc. Anatomical studies have shown that D1STR neurons have collaterals that terminate in GP. Adding these collaterals to the model, we found that striatal activation increased the intra-burst firing frequency of the disinhibition burst as the weight of this connection was increased. Our studies suggest that striatal activation is a robust means by which disinhibition bursts can be generated by SNpc dopaminergic neurons, and that recruitment of the indirect pathway via collaterals may enhance disinhibition bursting.

  5. Coupling and noise induced spiking-bursting transition in a parabolic bursting model.

    Science.gov (United States)

    Ji, Lin; Zhang, Jia; Lang, Xiufeng; Zhang, Xiuhui

    2013-03-01

    The transition from tonic spiking to bursting is an important dynamic process that carry physiologically relevant information. In this work, coupling and noise induced spiking-bursting transition is investigated in a parabolic bursting model with specific discussion on their cooperation effects. Fast/slow analysis shows that weak coupling may help to induce the bursting by changing the geometric property of the fast subsystem so that the original unstable periodical solution are stabilized. It turned out that noise can play the similar stabilization role and induce bursting at appropriate moderate intensity. However, their cooperation may either strengthen or weaken the overall effect depending on the choice of noise level.

  6. Factors Influencing the Iterative Accuracy of Ground Water Level in Forecasting the Water Burst of Deep Drawdown Mines

    Institute of Scientific and Technical Information of China (English)

    李铎; 杨小荟; 武强; 张志忠

    2002-01-01

    The purpose of this paper is to discuss the influential factors of iteration accuracy when we use iteration to determine the numerical model for predicting water yield of deep drawdown mines and calculating the groundwater level. The relationship among the calculation error of groundwater level, the pumping rate, the limit of iteration convergence error, the calculation time, and the aquifer parameters were discussed by using an ideal model. Finally, the water yield of Dianzi iron mine was predicted using the testified numerical model. It is indicated that the calculation error of groundwater level is related to the limit of iteration convergence error, the calculation time and the aquifer parameters, but not to the pumping rate and the variation of groundwater level.

  7. Analysis of the electrosensory pyramidal cell bursting model for weakly electric fish: model prediction under low levels of dendritic potassium conductance.

    Science.gov (United States)

    Shirahata, T

    2012-09-01

    Pyramidal cells in the electrosensory lateral line lobe (ELL) of weakly electric fish produce burst discharge. A Hodgkin-Huxley-type model, called ghostburster, consisting of two compartments (soma and dendrite) reproduces ELL pyramidal cell bursting observed in vitro. A previous study analyzed the ghostburster by treating Is and gDr,d as bifurcation parameters (Is: current injected into the somatic compartment and gDr,d: maximal conductance of the delayed rectifying potassium current in the dendritic compartment) and indicated that when both Is and gDr,d are set at particular values, the ghostburster shows a codimension-two bifurcation at which both saddle-node bifurcation of fixed points and saddle-node bifurcation of limit cycles occur simultaneously. In the present study, the ghostburster was investigated to clarify the bursting that occurred at gDr,d values smaller than that at the codimension-two bifurcation. Based on the number of spikes per burst, various burst patterns were observed depending on the (Is, gDr,d) values. Depending on the (Is, gDr,d) values, the burst trajectory in a phase space of the ghostburster showed either a high or a low degree of periodicity. Compared to the previous study, the present findings contribute to a more detailed understanding of ghostburster bursting.

  8. Selective suppression of rod signal transmission by cobalt ions of low levels in carp retina

    Institute of Scientific and Technical Information of China (English)

    袁澧涟; 杨雄里

    1997-01-01

    Selective suppression of rod signal transmission by cobalt ions was reported in carp retina. Using 10 μmol/L Co2+ , rod-driven horizontal cells were hyperpolarized and light responses were completely suppressed in super-fused, isolated retina, while cone-driven horizontal cells were almost unaffected. Similarly, scotopic electroretino-graphic b-wave was suppressed by 10 μmol/L Co2+ , while the photopic b-wave remained unaffected. Furthermore, the glutamate-isolated receptor potential (PIII) was not altered by low Co2+ under dark-adapted conditions. Other di-valent ions with high affinity to calcium channels, such as cadmium and manganese ions, did not show similar suppres-sive effect on the rod horizontal cells. When rod horizontal cells were hyperpolarized by 10 μmol/L Co2+ , the use of 3 mmol/L glutamate caused a significant depolarization of the cells, indicating that Co2+ application did not impair the ability of these cells to respond to glutamate. On the other hand, application of 200 μmol/L ?

  9. Minimum requirement of artificial noise level for using noise-assisted correlation algorithm to suppress artifacts in ultrasonic Nakagami images.

    Science.gov (United States)

    Tsui, Po-Hsiang

    2012-04-01

    The Nakagami image is a complementary imaging mode for pulse-echo ultrasound B-scan to characterize tissues. White noise in anechoic areas induces artifacts in the Nakagami image. Recently, we proposed a noise-assisted correlation algorithm (NCA) for suppressing the Nakagami artifact. In the NCA, artificial white noise is intentionally added twice to backscattered signals to produce two noisy data, which are used to establish a correlation profile for rejecting noise. This study explored the effects of artificial noise level on the NCA to suppress the artifact of the Nakagami image. Simulations were conducted to produce B-mode images of anechoic regions under signal-to-noise ratios (SNRs) of 20, 10 and 5 dB. Various artificial noise levels ranging from 0.1- to 1-fold of the intrinsic noise amplitude were used in the NCA for constructing the Nakagami images. Phantom experiments were conducted to validate the performance of using the optimal artificial noise level suggested by the simulation results to suppress the Nakagami artifacts by the NCA. The simulation results indicated that the artifacts of the Nakagami image in the anechoic regions can be gradually suppressed by increasing the artificial noise level used in the NCA to improve the image contrast-to-noise ratio (CNR). The CNR of the Nakagami image reached 20 dB when the artificial noise level was 0.7-fold of the intrinsic noise amplitude. This criterion was demonstrated by the phantom results to provide the NCA with an excellent ability to obtain artifact-free Nakagami images.

  10. Dual Stimulus-Dependent Effect of Oenothera paradoxa Extract on the Respiratory Burst in Human Leukocytes: Suppressing for Escherichia coli and Phorbol Myristate Acetate and Stimulating for Formyl-Methionyl-Leucyl-Phenylalanine

    Directory of Open Access Journals (Sweden)

    Izabela Burzynska-Pedziwiatr

    2014-01-01

    Full Text Available Although a growing body of evidence suggests that plant polyphenols can modulate human immune responses, their simultaneous action on monocyte and neutrophil oxidative burst is currently poorly understood. Based on the hypothesis that various polyphenols contained in plant extracts might affect the oxidative burst of phagocytes, we evaluated the effects of ethanolic O. paradoxa extract polyphenols on monocyte and neutrophil oxidative burst in vitro activated by different stimuli, including opsonized bacteria E. coli, phorbol 12-myristate 13-acetate (PMA, and formyl-methionyl-leucyl-phenylalanine (fMLP. Samples were analyzed by the dihydrorhodamine flow cytometry assay. Our results showed that the extract repressed significantly and dose-dependently reactive oxygen species production in both cell types stimulated with E. coli and PMA (P < 0.05 and its inhibitory efficiency was stimulus- and cell-type-dependent. Interestingly, there was significant stimulatory effect of the extract on bursting phagocytes induced by fMLP (P < 0.05. Additionally, several flavonoids and phenolic compounds as well as penta-galloyl-β-(D-glucose (PGG, the representative of hydrolyzable tannins, were identified in the 60% extract by high-performance liquid chromatography (HPLC coupled to electrospray ionization in negative ion mode. In summary, the ethanolic O. paradoxa extract, rich in flavonoids and phenolic compounds, exhibits dual stimulus-dependent effect on the respiratory burst in human leukocytes; hence, it might affect immune responses in humans.

  11. Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation.

    Science.gov (United States)

    Hartman, Tiffiney R; Zinshteyn, Daniel; Schofield, Heather K; Nicolas, Emmanuelle; Okada, Ami; O'Reilly, Alana M

    2010-11-29

    Stem cells depend on signals from cells within their microenvironment, or niche, as well as factors secreted by distant cells to regulate their maintenance and function. Here we show that Boi, a Hedgehog (Hh)-binding protein, is a novel suppressor of proliferation of follicle stem cells (FSCs) in the Drosophila ovary. Hh is expressed in apical cells, distant from the FSC niche, and diffuses to reach FSCs, where it promotes FSC proliferation. We show that Boi is expressed in apical cells and exerts its suppressive effect on FSC proliferation by binding to and sequestering Hh on the apical cell surface, thereby inhibiting Hh diffusion. Our studies demonstrate that cells distant from the local niche can regulate stem cell function through ligand sequestration, a mechanism that likely is conserved in other epithelial tissues.

  12. Suppression of Phase and Amplitude Damping Decoherence in a Three-Level Atom in A-Configuration Using Bang-Bang Controls

    Institute of Scientific and Technical Information of China (English)

    WANG Yan-Hui; LIU Xiao-Shu; LONG Gui-Lu

    2007-01-01

    In this paper, we present decoupling bang-bang operations for the suppression of general decoherence, both amplitude and phase damping, in a three-level system in A-configuration. We give a program to design a sequence of periodic twinborn pulses to suppress the decoherence in such the system.

  13. Burst Mechanisms in Hydrodynamics

    CERN Document Server

    Knobloch, E

    1999-01-01

    Different mechanisms believed to be responsible for the generation of bursts in hydrodynamical systems are reviewed and a new mechanism capable of generating regular or irregular bursts of large dynamic range near threshold is described. The new mechanism is present in the interaction between oscillatory modes of odd and even parity in systems of large but finite aspect ratio, and provides an explanation for the bursting behavior observed in binary fluid convection. Additional applications of the new mechanism are proposed.

  14. Propeller tone bursts

    Science.gov (United States)

    Succi, G. P.; Munro, D. H.; Ingard, K. U.

    1983-01-01

    Intense high frequency (25-38 kHz) tone bursts have been observed in acoustic tests of a scale model of a general aviation propeller. The amplitude of the tone burst is approximately equal to the amplitude of the propeller noise signature. The conditions necessary for the production of these tone bursts are described. The experiments indicate that the origin of these bursts is a periodic flow oscillation on the suction surface of the propeller blade tips which may be due to the interaction between an oscillating shock wave and a laminar boundary layer.

  15. Online tremor suppression using electromyography and low-level electrical stimulation.

    Science.gov (United States)

    Dosen, Strahinja; Muceli, Silvia; Dideriksen, Jakob Lund; Romero, Juan Pablo; Rocon, Eduardo; Pons, Jose; Farina, Dario

    2015-05-01

    Tremor is one of the most prevalent movement disorders. There is a large proportion of patients (around 25%) in whom current treatments do not attain a significant tremor reduction. This paper proposes a tremor suppression strategy that detects tremor from the electromyographic signals of the muscles from which tremor originates and counteracts it by delivering electrical stimulation to the antagonist muscles in an out of phase manner. The detection was based on the iterative Hilbert transform and stimulation was delivered above the motor threshold (motor stimulation) and below the motor threshold (sensory stimulation). The system was tested on six patients with predominant wrist flexion/extension tremor (four with Parkinson disease and two with Essential tremor) and led to an average tremor reduction in the range of 46%-81% and 35%-48% across five patients when using the motor and sensory stimulation, respectively. In one patient, the system did not attenuate tremor. These results demonstrate that tremor attenuation might be achieved by delivering electrical stimulation below the motor threshold, preventing muscle fatigue and discomfort for the patients, which sets the basis for the development of an alternative treatment for tremor.

  16. Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning.

    Directory of Open Access Journals (Sweden)

    Graham K Sheridan

    Full Text Available Over four decades ago, it was discovered that high-frequency stimulation of the dentate gyrus induces long-term potentiation (LTP of synaptic transmission. LTP is believed to underlie how we process and code external stimuli before converting it to salient information that we store as 'memories'. It has been shown that rats performing spatial learning tasks display theta-frequency (3-12 Hz hippocampal neural activity. Moreover, administering theta-burst stimulation (TBS to hippocampal slices can induce LTP. TBS triggers a sustained rise in intracellular calcium [Ca2+]i in neurons leading to new protein synthesis important for LTP maintenance. In this study, we measured TBS-induced [Ca2+]i oscillations in thousands of cells at increasing distances from the source of stimulation. Following TBS, a calcium wave propagates radially with an average speed of 5.2 µm/s and triggers multiple and regular [Ca2+]i oscillations in the hippocampus. Interestingly, the number and frequency of [Ca2+]i fluctuations post-TBS increased with respect to distance from the electrode. During the post-tetanic phase, 18% of cells exhibited 3 peaks in [Ca2+]i with a frequency of 17 mHz, whereas 2.3% of cells distributed further from the electrode displayed 8 [Ca2+]i oscillations at 33 mHz. We suggest that these observed [Ca2+]i oscillations could lead to activation of transcription factors involved in synaptic plasticity. In particular, the transcription factor, NF-κB, has been implicated in memory formation and is up-regulated after LTP induction. We measured increased activation of NF-κB 30 min post-TBS in CA1 pyramidal cells and also observed similar temporal up-regulation of NF-κB levels in CA1 neurons following water maze training in rats. Therefore, TBS of hippocampal slice cultures in vitro can mimic the cell type-specific up-regulations in activated NF-κB following spatial learning in vivo. This indicates that TBS may induce similar transcriptional changes to

  17. The activity of satellite cells and myonuclei following 8 weeks of strength training in young men with suppressed testosterone levels

    DEFF Research Database (Denmark)

    Kvorning, T; Kadi, F; Schjerling, P

    2015-01-01

    AIM: To investigate how suppression of endogenous testosterone during an 8-week strength training period influences the activity of satellite cells and myonuclei. METHODS: Twenty-two moderately trained young men participated in this randomized, placebo-controlled, and double-blinded intervention...... from the mid-portion of the vastus lateralis muscle. RESULTS: Testosterone resting level in goserelin was 10-20 times lower compared with placebo, and the training-induced increase in the level of testosterone was abolished in goserelin. Training increased satellite cells number in type II fibres by 20......% in placebo and by 52% in goserelin (P cells and myonuclei were seen in type I fibres in either group. Data from the microarray analysis...

  18. Serum levels of antimüllerian hormone in early maturing girls before, during, and after suppression with GnRH agonist

    DEFF Research Database (Denmark)

    Hagen, Casper P; Sørensen, Kaspar; Anderson, Richard A;

    2012-01-01

    To evaluate whether serum antimüllerian hormone (AMH) levels are affected in early maturing girls, and whether pituitary suppression by long-acting GnRH agonist (GnRH-a) affects AMH.......To evaluate whether serum antimüllerian hormone (AMH) levels are affected in early maturing girls, and whether pituitary suppression by long-acting GnRH agonist (GnRH-a) affects AMH....

  19. Agrotecnólogical characteristics of cane sugar at different times of suppression of irrigation and fertilizer levels

    Directory of Open Access Journals (Sweden)

    Franklin Meireles de Oliveira

    2014-06-01

    Full Text Available The objective of this study was to evaluate the performance of Agrotechnological two varieties of cane sugar influenced by different times of deletions irrigation and fertilization levels. The characteristics evaluated were: plant height (m, stem diameter (mm, number of tillers m- 1, Brix broth, sugar cane Pol, Pol broth, Sugar reducer, and overall productivity. The experiment was conducted in the Experimental Farm area Unimontes in Janaúba in northern Minas Gerais. The experimental design was a randomized complete block design with three replications in a split plot (2 x 3 x 6 , two varieties of cane sugar, RB85 and 5453 SP80 1816, three different times suppression of irrigation (DIAP and six different levels of NK fertilization. Data were subjected to analysis of variance, and when significant differences were the F test was performed to compare the means by Scott Knott (p<0.05 for all variables, using the software program SISVAR. The varieties showed different behavior at maturity, having variety RB85 5453 higher values in technological quality and productivity at lower rates. The varieties obtained overall average of 24.3 ° Brix, Pol 17.6 % of sugarcane, 21 % Pol broth, 0.6 % AR, 3:08 meters in height, 29.2 mm in diameter, 18.9 tillers m-1, 11.1 stems m-1, t ha-1 159.8 productivity. The varieties responded to different eras of suppression irrigation (DIAP. 6 The level of fertilization provided better performance in terms of this work. The RB85 - 5453 and SP80 -1816 varieties are promising for Nortemineira region.

  20. Bursting synchronization in clustered neuronal networks

    Institute of Scientific and Technical Information of China (English)

    Yu Hai-Tao; Wang Jiang; Deng Bin; Wei Xi-Le

    2013-01-01

    Neuronal networks in the brain exhibit the modular (clustered) property,i.e.,they are composed of certain subnetworks with differential internal and external connectivity.We investigate bursting synchronization in a clustered neuronal network.A transition to mutual-phase synchronization takes place on the bursting time scale of coupled neurons,while on the spiking time scale,they behave asynchronously.This synchronization transition can be induced by the variations of inter-and intracoupling strengths,as well as the probability of random links between different subnetworks.Considering that some pathological conditions are related with the synchronization of bursting neurons in the brain,we analyze the control of bursting synchronization by using a time-periodic external signal in the clustered neuronal network.Simulation results show a frequency locking tongue in the driving parameter plane,where bursting synchronization is maintained,even in the presence of external driving.Hence,effective synchronization suppression can be realized with the driving parameters outside the frequency locking region.

  1. Ingestion of sodium citrate suppresses aldosterone level in blood at rest and during exercise.

    Science.gov (United States)

    Oöpik, Vahur; Timpmann, Saima; Hackney, Anthony C; Kadak, Kadri; Medijainen, Luule; Karelson, Kalle

    2010-06-01

    The purpose of this study was to determine if the ingestion of sodium citrate (CIT) alters blood levels of fluid and electrolyte regulatory hormones at rest and during exercise. Using a randomized, double-blinded, crossover design, 13 young, male well-trained runners performed continuous incremental running tests to volitional exhaustion on a treadmill 2 h after ingestion of 0.5 g.kg-1 body mass of CIT or placebo (PLC) in 1000 mL of solution. These trials were separated by 2 weeks. Baseline (before ingestion) aldosterone concentration did not differ between the 2 trials; however, it was 36.5% (p = 0.003) lower in the CIT trial compared with the PLC trial before the running test (i.e., after ingestion). The extent of the running-induced increase in aldosterone was 33% (p = 0.009) smaller in the CIT trial. There were no between-trial differences in the levels of adrenocorticotropic hormone, N-terminal pro-B-type natriuretic peptide, or renin activity at any stage of the study. However, a greater relative increase in plasma volume (mean +/- SD, 6.41% +/- 3.78% vs. 4.08% +/- 3.33%; p = 0.042) was observed after administering the CIT compared with the PLC drink. Serum Na+ concentration increased (by 3.1 +/- 1.2 mmol.L-1; p < 0.0001) after ingestion of the CIT but not the PLC drink. A higher Na+ level was observed in the CIT trial than in the PLC trial (142.4 +/- 1.6 vs. 139.3 +/- 1.4 mmol.L-1, p = 0.00001) after completion of the run. In conclusion, pre-exercise ingestion of CIT induces a decrease in serum aldosterone concentration in the resting condition and a blunting of the aldosterone response during incremental running exercise to volitional exhaustion. The observed effect of CIT on the serum aldosterone level may be mediated by an acute increase in plasma volume and serum Na+ concentration alterations.

  2. Cholesterol-Induced Suppression of Membrane Elastic Fluctuations at the Atomistic Level

    Science.gov (United States)

    Molugu, Trivikram R.

    2017-01-01

    Applications of solid-state NMR spectroscopy for investigating the influences of lipid-cholesterol interactions on membrane fluctuations are reviewed in this paper. Emphasis is placed on understanding the energy landscapes and fluctuations at an emergent atomistic level. Solid-state 2H NMR spectroscopy directly measures residual quadrupolar couplings (RQCs) due to individual C–2H labeled segments of the lipid molecules. Moreover, residual dipolar couplings (RDCs) of 13C–1H bonds are obtained in separated local-field NMR spectroscopy. The distributions of RQC or RDC values give nearly complete profiles of the order parameters as a function of acyl segment position. Measured equilibrium properties of glycerophospholipids and sphingolipids including their binary and tertiary mixtures with cholesterol show unequal mixing associated with liquid-ordered domains. The entropic loss upon addition of cholesterol to sphingolipids is less than for glycerophospholipids and may drive the formation of lipid rafts. In addition relaxation time measurements enable one to study the molecular dynamics over a wide time-scale range. For 2H NMR the experimental spin-lattice (R1Z) relaxation rates follow a theoretical square-law dependence on segmental order parameters (SCD) due to collective slow dynamics over mesoscopic length scales. The functional dependence for the liquid-crystalline lipid membranes is indicative of viscoelastic properties as they emerge from atomistic-level interactions. A striking decrease in square-law slope upon addition of cholesterol denotes stiffening relative to the pure lipid bilayers that is diminished in the case of lanosterol. Measured equilibrium properties and relaxation rates infer opposite influences of cholesterol and detergents on collective dynamics and elasticity at an atomistic scale that potentially affects lipid raft formation in cellular membranes. PMID:27154600

  3. Cholesterol-induced suppression of membrane elastic fluctuations at the atomistic level.

    Science.gov (United States)

    Molugu, Trivikram R; Brown, Michael F

    2016-09-01

    Applications of solid-state NMR spectroscopy for investigating the influences of lipid-cholesterol interactions on membrane fluctuations are reviewed in this paper. Emphasis is placed on understanding the energy landscapes and fluctuations at an emergent atomistic level. Solid-state (2)H NMR spectroscopy directly measures residual quadrupolar couplings (RQCs) due to individual C-(2)H labeled segments of the lipid molecules. Moreover, residual dipolar couplings (RDCs) of (13)C-(1)H bonds are obtained in separated local-field NMR spectroscopy. The distributions of RQC or RDC values give nearly complete profiles of the order parameters as a function of acyl segment position. Measured equilibrium properties of glycerophospholipids and sphingolipids including their binary and tertiary mixtures with cholesterol show unequal mixing associated with liquid-ordered domains. The entropic loss upon addition of cholesterol to sphingolipids is less than for glycerophospholipids and may drive the formation of lipid rafts. In addition relaxation time measurements enable one to study the molecular dynamics over a wide time-scale range. For (2)H NMR the experimental spin-lattice (R1Z) relaxation rates follow a theoretical square-law dependence on segmental order parameters (SCD) due to collective slow dynamics over mesoscopic length scales. The functional dependence for the liquid-crystalline lipid membranes is indicative of viscoelastic properties as they emerge from atomistic-level interactions. A striking decrease in square-law slope upon addition of cholesterol denotes stiffening relative to the pure lipid bilayers that is diminished in the case of lanosterol. Measured equilibrium properties and relaxation rates infer opposite influences of cholesterol and detergents on collective dynamics and elasticity at an atomistic scale that potentially affects lipid raft formation in cellular membranes.

  4. Theta, alpha and beta burst transcranial magnetic stimulation: brain modulation in tinnitus

    Directory of Open Access Journals (Sweden)

    Dirk De Ridder, Elsa van der Loo, Karolien Van der Kelen, Tomas Menovsky, Paul van de Heyning, Aage Moller

    2007-01-01

    Full Text Available Introduction: Some forms of tinnitus are considered to be auditory phantom phenomena related to reorganization and hyperactivity of the auditory central nervous system. Repetitive transcranial magnetic stimulation (rTMS is a non-invasive tool capable of modulating human brain activity, using single pulse or burst stimuli. Burst rTMS has only been performed in the theta range, and has not been used clinically. The authors analyze whether burst TMS at theta (5 Hz, alpha (10 Hz and beta (20 Hz frequencies can temporarily suppress narrow band noise/white noise tinnitus, which has been demonstrated to be intractable to tonic stimulation. Methods: rTMS is performed both in tonic and burst mode in 46 patients contralateral to the tinnitus side, at 5, 10 and 20 Hz. Fourteen placebo negative rTMS responders are further analyzed. Results: In 5 patients, maximal tinnitus suppression is obtained with theta, in 2 with alpha and in 7 with beta burst stimulation. Burst rTMS suppresses narrow band/white tinnitus much better than tonic rTMS t(13=6.4, p<.000. Women experience greater suppression of their tinnitus with burst stimulation than men, t(12=2.9, p<.05. Furthermore left sided tinnitus is perceived as more distressing on the TQ than right sided tinnitus, t(12=3.2, p<.01. The lower the tinnitus pitch the more effectively rTMS suppresses tinnitus(r=-0.65, p<0.05. Discussion: Burst rTMS can be used clinically, not only theta burst, but also alpha and beta burst. Burst rTMS is capable of suppressing narrow band/white noise tinnitus very much better than tonic rTMS. This could be due the simple fact that burst neuromodulation is more powerful than tonic neuromodulation or to a differential effect of burst and tonic stimulation on the lemniscal and extralemniscal auditory system. In some patients only alpha or beta burst rTMS is capable of suppressing tinnitus, and theta burst not. Therefore in future rTMS studies it could be worthwhile not to limit burst

  5. The Drift Burst Hypothesis

    DEFF Research Database (Denmark)

    Christensen, Kim; Oomen, Roel; Renò, Roberto

    The Drift Burst Hypothesis postulates the existence of short-lived locally explosive trends in the price paths of financial assets. The recent US equity and Treasury flash crashes can be viewed as two high profile manifestations of such dynamics, but we argue that drift bursts of varying magnitude......, currencies and commodities. We find that the majority of identified drift bursts are accompanied by strong price reversals and these can therefore be regarded as “flash crashes” that span brief periods of severe market disruption without any material longer term price impacts....

  6. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels.

    Science.gov (United States)

    Rasmussen, D D; Boldt, B M; Wilkinson, C W; Yellon, S M; Matsumoto, A M

    1999-02-01

    Human and rat pineal melatonin secretion decline with aging, whereas visceral fat and plasma insulin levels increase. Melatonin modulates fat metabolism in some mammalian species, so these aging-associated melatonin, fat and insulin changes could be functionally related. Accordingly, we investigated the effects of daily melatonin supplementation to male Sprague-Dawley rats, starting at middle age (10 months) and continuing into old age (22 months). Melatonin was added to the drinking water (92% of which was consumed at night) at a dosage (4 microg/ml) previously reported to attenuate the aging-associated decrease in survival rate in male rats, as well as at a 10-fold lower dosage. The higher dosage produced nocturnal plasma melatonin levels in middle-aged rats which were 15-fold higher than in young (4 months) rats; nocturnal plasma melatonin levels in middle-aged rats receiving the lower dosage were not significantly different from young or middle-aged controls. Relative (% of body wt) retroperitoneal and epididymal fat, as well as plasma insulin and leptin levels, were all significantly increased at middle age when compared to young rats. All were restored within 10 weeks to youthful (4 month) levels in response to both dosages of melatonin. Continued treatment until old age maintained suppression of visceral (retroperitoneal + epididymal) fat levels. Plasma corticosterone and total thyroxine (T4) levels were not significantly altered by aging or melatonin treatment. Plasma testosterone, insulin-like growth factor I (IGF-I) and total triiodothyronine (T3) decreased by middle age; these aging-associated decreases were not significantly altered by melatonin treatment. Thus, visceral fat, insulin and leptin responses to melatonin administration may be independent of marked changes in gonadal, thyroid, adrenal or somatotropin regulation. Since increased visceral fat is associated with increased insulin resistance, diabetes, and cardiovascular disease, these results

  7. Desynchronization in an ensemble of globally coupled chaotic bursting neuronal oscillators by dynamic delayed feedback control

    CERN Document Server

    Che, Yanqiu; Li, Ruixue; Li, Huiyan; Han, Chunxiao; Wang, Jiang; Wei, Xile

    2014-01-01

    In this paper, we propose a dynamic delayed feedback control approach for desynchronization of chaotic-bursting synchronous activities in an ensemble of globally coupled neuronal oscillators. We demonstrate that the difference signal between an ensemble's mean field and its time delayed state, filtered and fed back to the ensemble, can suppress the self-synchronization in the ensemble. These individual units are decoupled and stabilized at the desired desynchronized states while the stimulation signal reduces to the noise level. The effectiveness of the method is illustrated by examples of two different populations of globally coupled chaotic-bursting neurons. The proposed method has potential for mild, effective and demand-controlled therapy of neurological diseases characterized by pathological synchronization.

  8. Extracellular calcium modulates persistent sodium current-dependent burst-firing in hippocampal pyramidal neurons.

    Science.gov (United States)

    Su, H; Alroy, G; Kirson, E D; Yaari, Y

    2001-06-15

    The generation of high-frequency spike bursts ("complex spikes"), either spontaneously or in response to depolarizing stimuli applied to the soma, is a notable feature in intracellular recordings from hippocampal CA1 pyramidal cells (PCs) in vivo. There is compelling evidence that the bursts are intrinsically generated by summation of large spike afterdepolarizations (ADPs). Using intracellular recordings in adult rat hippocampal slices, we show that intrinsic burst-firing in CA1 PCs is strongly dependent on the extracellular concentration of Ca(2+) ([Ca(2+)](o)). Thus, lowering [Ca(2+)](o) (by equimolar substitution with Mn(2+) or Mg(2+)) induced intrinsic bursting in nonbursters, whereas raising [Ca(2+)](o) suppressed intrinsic bursting in native bursters. The induction of intrinsic bursting by low [Ca(2+)](o) was associated with enlargement of the spike ADP. Low [Ca(2+)](o)-induced intrinsic bursts and their underlying ADPs were suppressed by drugs that reduce the persistent Na(+) current (I(NaP)), indicating that this current mediates the slow burst depolarization. Blocking Ca(2+)-activated K(+) currents with extracellular Ni(2+) or intracellular chelation of Ca(2+) did not induce intrinsic bursting. This and other evidence suggest that lowering [Ca(2+)](o) may induce intrinsic bursting by augmenting I(NaP). Because repetitive neuronal activity in the hippocampus is associated with marked decreases in [Ca(2+)](o), the regulation of intrinsic bursting by extracellular Ca(2+) may provide a mechanism for preferential recruitment of this firing mode during certain forms of hippocampal activation.

  9. CRP and SAA1 Haplotypes Are Associated with Both C-Reactive Protein and Serum Amyloid A Levels: Role of Suppression Effects

    Directory of Open Access Journals (Sweden)

    Yu-Lin Ko

    2016-01-01

    Full Text Available To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation analysis revealed that C-reactive protein (CRP and serum amyloid A (SAA levels were significantly associated with multiple metabolic phenotypes and inflammatory marker levels. Our data further revealed a significant association of CRP and SAA1 variants with both CRP and SAA levels. Mediation analysis revealed that SAA levels suppressed the association between SAA1 genotypes/haplotypes and CRP levels and that CRP levels suppressed the association between CRP haplotypes and SAA levels. In conclusion, genetic variants at the CRP and SAA1 loci independently affect both CRP and SAA levels, and their respective circulating levels act as suppressors. These results provided further evidence of the role of the suppression effect in biological science and may partially explain the missing heritability in genetic association studies.

  10. Interplanetary Type IV Bursts

    CERN Document Server

    Hillaris, Alexander; Nindos, Alexander

    2016-01-01

    In this work we study the characteristics of moving type IV radio bursts which extend to the hectometric wavelengths (interplanetary type IV or type IV IP bursts) and their relationship with energetic phenomena on the Sun. Our dataset comprised 48 Interplanetary type IV bursts observed by the Wind/WAVES in the 13.825 MHz?20 KHz frequency range. The dynamic spec tra of the RSTN, DAM, ARTEMIS-IV, CULGOORA, Hiraiso and IZMIRAN Radio-spectrographs were used to track the evolution of the events in the low corona; these were supplemented with SXR ?ux recordings from GOES and CME data from LASCO. Positional information for the coronal bursts were obtained by the Nan\\c{c}ay radioheliograph (NRH). We examined the relationship of the type IV events with coronal radio bursts, CMEs and SXR ?ares. The majority of the events (45) were characterized as compact; their duration was on average 106 min. This type of events were, mostly, associated with M and X class ?ares (40 out of 45) and fast CMEs; 32 of these events had CME...

  11. A Burst to See

    Science.gov (United States)

    2008-04-01

    On 19 March, Nature was particularly generous and provided astronomers with the wealth of four gamma-ray bursts on the same day. But that was not all: one of them is the most luminous object ever observed in the Universe. Despite being located in a distant galaxy, billions of light years away, it was so bright that it could have been seen, for a brief while, with the unaided eye. ESO PR Photo 08a/08 ESO PR Photo 08a/08 The REM Telescope and TORTORA Camera Gamma-ray bursts (GRBs) are short flashes of energetic gamma-rays lasting from less than a second to several minutes. They release a tremendous quantity of energy in this short time making them the most powerful events since the Big Bang. It is now widely accepted that the majority of the gamma-ray bursts signal the explosion of very massive, highly evolved stars that collapse into black holes. Gamma-ray bursts, which are invisible to our eyes, are discovered by telescopes in space. After releasing their intense burst of high-energy radiation, they become detectable for a short while in the optical and in the near-infrared. This 'afterglow' fades very rapidly, making detailed analysis possible for only a few hours after the gamma-ray detection. This analysis is important in particular in order to determine the GRB's distance and, hence, intrinsic brightness. The gamma-ray burst GRB 080319B was detected by the NASA/STFC/ASI Swift satellite. "It was so bright that it almost blinded the Swift instruments for a while," says Guido Chincarini, Italian principal investigator of the mission. A bright optical counterpart was soon identified in the Boötes Constellation (the "Bear Driver" or "Herdsman"). A host of ground-based telescopes reacted promptly to study this new object in the sky. In particular, the optical emission was detected by a few wide-field cameras on telescopes that constantly monitor a large fraction of the sky, including the TORTORA camera in symbiosis with the 0.6-m REM telescope located at La Silla

  12. Interplanetary Type IV Bursts

    Science.gov (United States)

    Hillaris, A.; Bouratzis, C.; Nindos, A.

    2016-08-01

    We study the characteristics of moving type IV radio bursts that extend to hectometric wavelengths (interplanetary type IV or type {IV}_{{IP}} bursts) and their relationship with energetic phenomena on the Sun. Our dataset comprises 48 interplanetary type IV bursts observed with the Radio and Plasma Wave Investigation (WAVES) instrument onboard Wind in the 13.825 MHz - 20 kHz frequency range. The dynamic spectra of the Radio Solar Telescope Network (RSTN), the Nançay Decametric Array (DAM), the Appareil de Routine pour le Traitement et l' Enregistrement Magnetique de l' Information Spectral (ARTEMIS-IV), the Culgoora, Hiraso, and the Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation (IZMIRAN) Radio Spectrographs were used to track the evolution of the events in the low corona. These were supplemented with soft X-ray (SXR) flux-measurements from the Geostationary Operational Environmental Satellite (GOES) and coronal mass ejections (CME) data from the Large Angle and Spectroscopic Coronagraph (LASCO) onboard the Solar and Heliospheric Observatory (SOHO). Positional information of the coronal bursts was obtained by the Nançay Radioheliograph (NRH). We examined the relationship of the type IV events with coronal radio bursts, CMEs, and SXR flares. The majority of the events (45) were characterized as compact, their duration was on average 106 minutes. This type of events was, mostly, associated with M- and X-class flares (40 out of 45) and fast CMEs, 32 of these events had CMEs faster than 1000 km s^{-1}. Furthermore, in 43 compact events the CME was possibly subjected to reduced aerodynamic drag as it was propagating in the wake of a previous CME. A minority (three) of long-lived type {IV}_{{IP}} bursts was detected, with durations from 960 minutes to 115 hours. These events are referred to as extended or long duration and appear to replenish their energetic electron content, possibly from electrons escaping from the corresponding coronal

  13. The Glast Burst Monitor

    Science.gov (United States)

    Meegan, Charles

    2000-01-01

    The Gamma-Ray Large Area Space Telescope (GLAST) will include a secondary instrument to augment the observatory's capabilities for GRB studies. The GLAST Burst Monitor (GBK is a collaboration between Marshall Space Flight Center, the University of Huntsville, Alabama, and the Max Plank Institute for Extraterrestrial Physics. The purpose of the GBM is to extend energy coverage below the main instrument's lower limit of about 20 MeV, and to provide an on-board burst trigger and approximate location. The instrument consists of twelve NaI detectors and two BGO detectors. This combination provides energy coverage from a few keV up to about 30 MeV.

  14. A Repeating Fast Radio Burst

    CERN Document Server

    Spitler, L G; Hessels, J W T; Bogdanov, S; Brazier, A; Camilo, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J; Ferdman, R D; Freire, P C C; Kaspi, V M; Lazarus, P; Lynch, R; Madsen, E C; McLaughlin, M A; Patel, C; Ransom, S M; Seymour, A; Stairs, I H; Stappers, B W; van Leeuwen, J; Zhu, W W

    2016-01-01

    Fast Radio Bursts are millisecond-duration astronomical radio pulses of unknown physical origin that appear to come from extragalactic distances. Previous follow-up observations have failed to find additional bursts at the same dispersion measures (i.e. integrated column density of free electrons between source and telescope) and sky position as the original detections. The apparent non-repeating nature of the fast radio bursts has led several authors to hypothesise that they originate in cataclysmic astrophysical events. Here we report the detection of ten additional bursts from the direction of FRB121102, using the 305-m Arecibo telescope. These new bursts have dispersion measures and sky positions consistent with the original burst. This unambiguously identifies FRB121102 as repeating and demonstrates that its source survives the energetic events that cause the bursts. Additionally, the bursts from FRB121102 show a wide range of spectral shapes that appear to be predominantly intrinsic to the source and wh...

  15. Is an absolute level of cortical beta suppression required for proper movement? Magnetoencephalographic evidence from healthy aging.

    Science.gov (United States)

    Heinrichs-Graham, Elizabeth; Wilson, Tony W

    2016-07-01

    Previous research has connected a specific pattern of beta oscillatory activity to proper motor execution, but no study to date has directly examined how resting beta levels affect motor-related beta oscillatory activity in the motor cortex. Understanding this relationship is imperative to determining the basic mechanisms of motor control, as well as the impact of pathological beta oscillations on movement execution. In the current study, we used magnetoencephalography (MEG) and a complex movement paradigm to quantify resting beta activity and movement-related beta oscillations in the context of healthy aging. We chose healthy aging as a model because preliminary evidence suggests that beta activity is elevated in older adults, and thus by examining older and younger adults we were able to naturally vary resting beta levels. To this end, healthy younger and older participants were recorded during motor performance and at rest. Using beamforming, we imaged the peri-movement beta event-related desynchronization (ERD) and extracted virtual sensors from the peak voxels, which enabled absolute and relative beta power to be assessed. Interestingly, absolute beta power during the pre-movement baseline was much stronger in older relative to younger adults, and older adults also exhibited proportionally large beta desynchronization (ERD) responses during motor planning and execution compared to younger adults. Crucially, we found a significant relationship between spontaneous (resting) beta power and beta ERD magnitude in both primary motor cortices, above and beyond the effects of age. A similar link was found between beta ERD magnitude and movement duration. These findings suggest a direct linkage between beta reduction during movement and spontaneous activity in the motor cortex, such that as spontaneous beta power increases, a greater reduction in beta activity is required to execute movement. We propose that, on an individual level, the primary motor cortices have an

  16. Connecting protein and mRNA burst distributions for stochastic models of gene expression

    CERN Document Server

    Elgart, Vlad; Fenley, Andrew T; Kulkarni, Rahul V

    2011-01-01

    The intrinsic stochasticity of gene expression can lead to large variability in protein levels for genetically identical cells. Such variability in protein levels can arise from infrequent synthesis of mRNAs which in turn give rise to bursts of protein expression. Protein expression occurring in bursts has indeed been observed experimentally and recent studies have also found evidence for transcriptional bursting, i.e. production of mRNAs in bursts. Given that there are distinct experimental techniques for quantifying the noise at different stages of gene expression, it is of interest to derive analytical results connecting experimental observations at different levels. In this work, we consider stochastic models of gene expression for which mRNA and protein production occurs in independent bursts. For such models, we derive analytical expressions connecting protein and mRNA burst distributions which show how the functional form of the mRNA burst distribution can be inferred from the protein burst distributio...

  17. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels

    DEFF Research Database (Denmark)

    Ucar, Ebru; Lehtinen, Emilia K; Glenthøj, Birte Y

    2012-01-01

    Sensory gating is frequently found to be disturbed in patients with schizophrenia. In addition, a disruption of the circadian rhythm together with a low nocturnal melatonin output is regularly found in these patients. Since there is some evidence that a brief period of sleep normalizes sensory...... gating in schizophrenia patients, it is conceivable that their disrupted melatonin level may contribute to the deficits in P50 suppression. In this initial study, the effects of acutely administered melatonin on sensory gating in healthy subjects were investigated. In a double-blind placebo......-controlled crossover design, 21 healthy male volunteers were administered melatonin (4 mg) or placebo, after which they were tested in a P50 suppression paradigm. In the group as a whole, melatonin did not affect P50 suppression. However, melatonin increased the P50 ratio in the individuals with high baseline...

  18. Meteor burst in the post 2000 era

    Science.gov (United States)

    Marriott, C.; Oduol, V.; Ghosh, A.; Tailor, B.

    In recent years a renewed interest has been shown in the possibility of using meteor burst links in tactical communications, both for networking and covert operations. Some of the applications that recent performance improvements would permit are evaluated. In evaluating the feasibility of a meteor burst implementation, certain technical and physical limitations are addressed. For the success of these applications, interoperability with other communication systems is necessary. The level of interoperability with other media, and the standards necessary to assure this interoperability are examined. Methods of minimizing and combating jamming are proposed. Meteor burst systems can be used in a large number of applications within a tactical environment. The principal disadvantage of the meteor burst medium is the problem of interference to other spectrum users from the probe end, and the interference from other users at the receiver end. The low throughput characteristic of meteor burst compares with some of the channel capacities used in other systems. Interoperability with other networks or communications links is relatively easy if certain straightforward protocols and standards are established.

  19. The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: the relationship between 25-hydroxyvitamin D and parathyroid hormone

    Science.gov (United States)

    Kang, Jung In; Lee, Yoon Suk; Han, Ye Jin; Kong, Kyoung Ae

    2017-01-01

    Purpose Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25-OHD level that suppresses the production of parathyroid hormone in children. Methods A retrospective record review was performed for children aged 0.2 to 18 years (n=193; 106 boys and 87 girls) who underwent simultaneous measurements of serum 25-OHD and PTH levels between January 2010 and June 2014. Results The inflection point of serum 25-OHD level for maximal suppression of PTH was at 18.0 ng/mL (95% confidence interval, 14.3–21.7 ng/mL). The median PTH level of the children with 25-OHD levels of <18.0 ng/mL was higher than that of children with 25-OHD levels ≥ 18.0 ng/mL (P<0.0001). The median calcium level of children with 25-OHD levels<18.0 ng/mL was lower than that of children with 25-OHD levels≥18.0 ng/mL (P=0.0001). The frequency of hyperparathyroidism was higher in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL (P<0.0001). Hypocalcemia was more prevalent in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL (P<0.0001). Conclusion These data suggest that a vitamin D level of 18.0 ng/mL could be the criterion for 25-OHD deficiency in children at the inflection point of the maximal suppression of PTH. PMID:28289433

  20. The Double Firing Burst

    Science.gov (United States)

    2008-09-01

    Astronomers from around the world combined data from ground- and space-based telescopes to paint a detailed portrait of the brightest explosion ever seen. The observations reveal that the jets of the gamma-ray burst called GRB 080319B were aimed almost directly at the Earth. Uncovering the disc ESO PR Photo 28/08 A Gamma-Ray Burst with Two Jets Read more on this illuminating blast in the additional story. GRB 080319B was so intense that, despite happening halfway across the Universe, it could have been seen briefly with the unaided eye (ESO 08/08). In a paper to appear in the 11 September issue of Nature, Judith Racusin of Penn State University, Pennsylvania (USA), and a team of 92 co-authors report observations across the electromagnetic spectrum that began 30 minutes before the explosion and followed it for months afterwards. "We conclude that the burst's extraordinary brightness arose from a jet that shot material almost directly towards Earth at almost the speed of light - the difference is only 1 part in 20 000," says Guido Chincarini, a member of the team. Gamma-ray bursts are the Universe's most luminous explosions. Most occur when massive stars run out of fuel. As a star collapses, it creates a black hole or neutron star that, through processes not fully understood, drives powerful gas jets outward. As the jets shoot into space, they strike gas previously shed by the star and heat it, thereby generating bright afterglows. The team believes the jet directed toward Earth contained an ultra-fast component just 0.4 degrees across (this is slightly smaller than the apparent size of the Full Moon). This jet is contained within another slightly less energetic jet about 20 times wider. The broad component is more typical of other bursts. "Perhaps every gamma-ray burst has a narrow jet, but astronomers miss it most of the time," says team member Stefano Covino. "We happened to view this monster down the barrel of the very narrow and energetic jet, and the chance for

  1. Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes.

    Science.gov (United States)

    Nosáľ, Radomír; Jančinová, Viera; Drábiková, Katarína; Perečko, Tomáš

    2015-04-01

    Antihistamines of the H₁and H₃/H₄groups interfere with oxidative burst of human professional phagocytes in vitro. In the concentration of 10 μM, H₁antihistamines of the 1st and 2nd generation inhibited oxidative burst of human neutrophils in the rank order of potency: dithiaden > loratadine > brompheniramine > chlorpheniramine > pheniramine. Of the H₁antihistamines, the most effective was dithiaden in suppressing oxidative burst of whole human blood and dose-dependently the chemiluminescence of isolated neutrophils at extra- and intracellular level. Inhibition of free oxygen radical generation in isolated neutrophils by dithiaden resulted from the inhibition of protein kinase C activation. The potentiation of recombinant caspase-3 by dithiaden is supportive of the antiinflammatory effect of dithiaden and suggestive of increasing the apoptosis of professional phagocytes. Of the H₃/H₄antihistamines, the most effective was JNJ7777120 in decreasing chemiluminescence in whole blood and also at extra- and intracellular sites of isolated neutrophils. JNJ 10191584 and thioperamide were less effective and the latter significantly potentiated free oxygen radical generation intracellularly. The results demonstrated that, compared with the H₃/H₄antihistamines investigated, H₁antihistamines were much more potent in inhibiting free oxygen radical generation in human professional phagocytes. This finding should be taken into account therapeutically.

  2. Solar Partial N-burst

    Institute of Scientific and Technical Information of China (English)

    Zong-Jun Ning; Yu-Ying Liu; Qi-Jun Fu; Fu-Ying Xu

    2003-01-01

    We present a new sub-class of type III solar radio burst at the highfrequencies around 6.0 GHz. In addition to a descending and an ascending branchon the dynamic spectrum, it has an inverted morphology different from the simpletype U-burst. We call it "partial N-burst" because it is interpreted as the knownN-burst minus its first branch. The partial N-burst presented here was detectedamong a reverse slope type III (RS-III) burst group prior to the type V solar radiocontinuum and was simultaneously recorded by two spectrometers at the NationalAstronomical Observatories, Chinese Academy of Sciences (NAOC, 5.20-7.60 GHz)and at Purple Mountain Observatory (PMO, 4.50-7.50 GHz) on 1999 August 25.After the N-burst and M-burst, the partial N-burst is a third piece of evidence for amagnetic mirror effect in solar radio observation, when the same electron is reflectedat a pinched foot of a flare loop.

  3. Gamma-ray burst spectra

    Science.gov (United States)

    Teegarden, B. J.

    1982-01-01

    A review of recent results in gamma-ray burst spectroscopy is given. Particular attention is paid to the recent discovery of emission and absorption features in the burst spectra. These lines represent the strongest evidence to date that gamma-ray bursts originate on or near neutron stars. Line parameters give information on the temperature, magnetic field and possibly the gravitational potential of the neutron star. The behavior of the continuum spectrum is also discussed. A remarkably good fit to nearly all bursts is obtained with a thermal-bremsstrahlung-like continuum. Significant evolution is observed of both the continuum and line features within most events.

  4. Retention on buprenorphine is associated with high levels of maximal viral suppression among HIV-infected opioid dependent released prisoners.

    Directory of Open Access Journals (Sweden)

    Sandra A Springer

    Full Text Available INTRODUCTION: HIV-infected prisoners lose viral suppression within the 12 weeks after release to the community. This prospective study evaluates the use of buprenorphine/naloxone (BPN/NLX as a method to reduce relapse to opioid use and sustain viral suppression among released HIV-infected prisoners meeting criteria for opioid dependence (OD. METHODS: From 2005-2010, 94 subjects meeting DSM-IV criteria for OD were recruited from a 24-week prospective trial of directly administered antiretroviral therapy (DAART for released HIV-infected prisoners; 50 (53% selected BPN/NLX and were eligible to receive it for 6 months; the remaining 44 (47% selected no BPN/NLX therapy. Maximum viral suppression (MVS, defined as HIV-1 RNA<50 copies/mL, was compared for the BPN/NLX and non-BPN/NLX (N = 44 groups. RESULTS: The two groups were similar, except the BPN/NLX group was significantly more likely to be Hispanic (56.0% v 20.4%, from Hartford (74.4% v 47.7% and have higher mean global health quality of life indicator scores (54.18 v 51.40. MVS after 24 weeks of being released was statistically correlated with 24-week retention on BPN/NLX [AOR = 5.37 (1.15, 25.1], having MVS at the time of prison-release [AOR = 10.5 (3.21, 34.1] and negatively with being Black [AOR = 0.13 (0.03, 0.68]. Receiving DAART or methadone did not correlate with MVS. CONCLUSIONS: In recognition that OD is a chronic relapsing disease, strategies that initiate and retain HIV-infected prisoners with OD on BPN/NLX is an important strategy for improving HIV treatment outcomes as a community transition strategy.

  5. Suppression of Allene Oxide Cyclase in Hairy Roots of Medicago truncatula Reduces Jasmonate Levels and the Degree of Mycorrhization with Glomus intraradices1[w

    Science.gov (United States)

    Isayenkov, Stanislav; Mrosk, Cornelia; Stenzel, Irene; Strack, Dieter; Hause, Bettina

    2005-01-01

    During the symbiotic interaction between Medicago truncatula and the arbuscular mycorrhizal (AM) fungus Glomus intraradices, an endogenous increase in jasmonic acid (JA) occurs. Two full-length cDNAs coding for the JA-biosynthetic enzyme allene oxide cyclase (AOC) from M. truncatula, designated as MtAOC1 and MtAOC2, were cloned and characterized. The AOC protein was localized in plastids and found to occur constitutively in all vascular tissues of M. truncatula. In leaves and roots, MtAOCs are expressed upon JA application. Enhanced expression was also observed during mycorrhization with G. intraradices. A partial suppression of MtAOC expression was achieved in roots following transformation with Agrobacterium rhizogenes harboring the MtAOC1 cDNA in the antisense direction under control of the cauliflower mosaic virus 35S promoter. In comparison to samples transformed with 35S∷uidA, roots with suppressed MtAOC1 expression exhibited lower JA levels and a remarkable delay in the process of colonization with G. intraradices. Both the mycorrhization rate, quantified by fungal rRNA, and the arbuscule formation, analyzed by the expression level of the AM-specific gene MtPT4, were affected. Staining of fungal material in roots with suppressed MtAOC1 revealed a decreased number of arbuscules, but these did not exhibit an altered structure. Our results indicate a crucial role for JA in the establishment of AM symbiosis. PMID:16244141

  6. Suppression of allene oxide cyclase in hairy roots of Medicago truncatula reduces jasmonate levels and the degree of mycorrhization with Glomus intraradices.

    Science.gov (United States)

    Isayenkov, Stanislav; Mrosk, Cornelia; Stenzel, Irene; Strack, Dieter; Hause, Bettina

    2005-11-01

    During the symbiotic interaction between Medicago truncatula and the arbuscular mycorrhizal (AM) fungus Glomus intraradices, an endogenous increase in jasmonic acid (JA) occurs. Two full-length cDNAs coding for the JA-biosynthetic enzyme allene oxide cyclase (AOC) from M. truncatula, designated as MtAOC1 and MtAOC2, were cloned and characterized. The AOC protein was localized in plastids and found to occur constitutively in all vascular tissues of M. truncatula. In leaves and roots, MtAOCs are expressed upon JA application. Enhanced expression was also observed during mycorrhization with G. intraradices. A partial suppression of MtAOC expression was achieved in roots following transformation with Agrobacterium rhizogenes harboring the MtAOC1 cDNA in the antisense direction under control of the cauliflower mosaic virus 35S promoter. In comparison to samples transformed with 35SuidA, roots with suppressed MtAOC1 expression exhibited lower JA levels and a remarkable delay in the process of colonization with G. intraradices. Both the mycorrhization rate, quantified by fungal rRNA, and the arbuscule formation, analyzed by the expression level of the AM-specific gene MtPT4, were affected. Staining of fungal material in roots with suppressed MtAOC1 revealed a decreased number of arbuscules, but these did not exhibit an altered structure. Our results indicate a crucial role for JA in the establishment of AM symbiosis.

  7. Dark Gamma Ray Bursts

    CERN Document Server

    Brdar, Vedran; Liu, Jia

    2016-01-01

    Many theories of dark matter (DM) predict that DM particles can be captured by stars via scattering on ordinary matter. They subsequently condense into a DM core close to the center of the star and eventually annihilate. In this work, we trace DM capture and annihilation rates throughout the life of a massive star and show that this evolution culminates in an intense annihilation burst coincident with the death of the star in a core collapse supernova. The reason is that, along with the stellar interior, also its DM core heats up and contracts, so that the DM density increases rapidly during the final stages of stellar evolution. We argue that, counterintuitively, the annihilation burst is more intense if DM annihilation is a p-wave process than for s-wave annihilation because in the former case, more DM particles survive until the supernova. If among the DM annihilation products are particles like dark photons that can escape the exploding star and decay to Standard Model particles later, the annihilation bu...

  8. 瑞芬太尼对丙泊酚靶控输注患者意识消失及诱发脑电爆发抑制时的半数有效浓度的影响%Effect of target-control infusion of remifentanil on concentration for 50% of maximal effect of propofol required for loss of consciousness and onset of EEG burst suppression

    Institute of Scientific and Technical Information of China (English)

    钟涛; 杨勇; 朱茂恩; 聂玉琼; 郭曲练

    2014-01-01

    目的:探讨丙泊酚 TCI 时患者意识消失(LOC)及诱发脑电爆发抑制(BS)时的效应室半数有效浓度(EC50)的影响。方法择期全麻手术患者60例,随机均分为瑞芬太尼组(R 组)和生理盐水组(N 组)。R 组:以4 ng/ml 靶浓度 TCI 瑞芬太尼10 min 后开始 TCI 丙泊酚,靶浓度从1μg/ml开始递增,递增梯度为1μg/ml,每一靶浓度输注1 min,至脑电监测爆发抑制比(BSR)达到15%后结束试验;N 组:以等量生理盐水模拟瑞芬太尼 TCI,其余方法与 R 组相同,期间所有患者每间隔20秒行改良 OAA/S 评分,改良 OAA/S 评分<2分定义为 LOC,BSR>15%定义为出现 BS 现象。记录 LOC 和 BSR 达15%时的丙泊酚 EC50及其95%可信区间(CI)。结果LOC 时 R 组丙泊酚效应室 EC50为1.73μg/ml(95%CI 1.68~1.79μg/ml),N 组为2.35μg/ml(95%CI 2.29~2.41μg/ml)(P<0.05)。BSR 达15%时 R 组和 N 组丙泊酚 EC50分别为6.25μg/ml (95%CI 6.18~6.42μg/ml)和6.31μg/ml(95%CI 6.13~6.47μg/ml),两组差异无统计学意义。结论复合 TCI 瑞芬太尼可降低丙泊酚 TCI 意识消失时的效应室 EC50,但对出现脑电爆发抑制时的丙泊酚效应室浓度无明显影响。%Objective To investigate the effect-site concentration for 50% of maximal effect (EC50 )of propofol required for loss of consciousness and onset of burst suppression and to assess the effect of target-control infusion(TCI)of remifentanil on these EC50 of propofol.Methods Sixty patients undergoning general anesthesia for scheduled surgery were randomly divided into 2 groups (n=30):group R received TCI of remifentanil with a target concentraton of 4 ng/ml 10 minutes before TCI of propofol,which started at a target plasma concentration of 1μg/ml and then increased by 1μg/ml step every 1 minute until the burst suppression ratio reach to 15%.Group N received a mock TCI of

  9. The underestimated challenges of burst-mode WDM transmission in TWDM-PON

    Science.gov (United States)

    Bonk, R.; Poehlmann, W.; van Veen, D.; Galaro, J.; Farah, R.; Schmuck, H.; Pfeiffer, Th.

    2015-12-01

    In this paper, the underestimated challenges of the burst-mode operation in the upstream path of time-and-wavelength-division-multiplexed passive optical networks are analyzed. Various challenges are disclosed, the influence of the associated physical effects on the signal quality is discussed and mitigation proposals are described: Intra-channel cross-talk can arise from optical network units induced background amplified-spontaneous emission noise and inter-channel cross-talk can be caused by non-ideal filter suppression between wavelength channels at the optical line termination receivers. Such cross-talk effects can be counteracted by reducing the laser burst-signal output power as well as its rival noise power simultaneously, i.e. by applying power leveling. A fast frequency drift in burst-mode operation is inherent to directly modulated lasers, but depends on the specific laser design, the laser output power and the burst length. Mitigation mechanisms are an optimized non-standard laser design or a specific mode of operation, e.g. an increase of the frequency drift during the preamble of the burst. The power dynamic range an optical pre-amplifier as part of the upstream signal receivers needs to handle can be in range of up to 40 dB, because of the multi-wavelength channel operation and of the optical distribution network differential path loss. This power dynamic faced at the receiver can not only cause challenges for the optical amplifier, but also for the burst-mode receivers. Additionally, the physical layer operation and maintenance of the upstream path is challenging too. Each optical network unit laser needs to be either wavelength pre-calibrated, which adds undesired costs or cross-channel synchronization of ranging windows has to be ensured. Otherwise rogue optical network unit behavior in wavelength and time domain will deteriorate system performance with every new optical network unit entering the network. Further, the operation of the optical

  10. Short duration gamma ray bursts

    Indian Academy of Sciences (India)

    Patrick Das Gupta

    2004-10-01

    After a short review of gamma ray bursts (GRBs), we discuss the physical implications of strong statistical correlations seen among some of the parameters of short duration bursts (90 < 2 s). Finally, we conclude with a brief sketch of a new unified model for long and short GRBs.

  11. Suppressed ion chromatography methods for the routine determination of ultra low level anions and cations in ice cores.

    Science.gov (United States)

    Curran, M A; Palmer, A S

    2001-06-01

    The concentration of trace ionic species in snow and ice samples was determined using suppressed ion chromatography (IC) with conductivity detection and ultra-clean sample preparation techniques. Trace anion species were determined in a single 24-min run by combining sample preconcentration with gradient elution using Na2B4O7 eluent. The detection limits (ranging from 0.001 to 0.006 microM) are the lowest reported in the literature. Cation species were analysed by direct injection of 0.25 ml and isocratic elution with a H2SO4 eluent. The clean preparation techniques showed no evidence of a difference (Student's t-test) between Milli-Q water samples analysed directly and processed Milli-Q ice samples. These robust, ultra-clean IC methods were routinely applied to the analysis of large number of samples to produce a high-resolution trace ion ice core record from Law Dome, East Antarctica.

  12. Are gamma-ray bursts cosmological?

    CERN Document Server

    Horvath, I

    2015-01-01

    Gamma-ray burst sources are distributed with a high level of isotropy, which is compatible with either a cosmological origin or an extended Galactic halo origin. The brightness distribution is another indicator used to characterize the spatial distribution in distance. In this paper the author discusses detailed fits of the BATSE gamma-ray burst peak-flux distributions with Friedmann models taking into account possible density evolution and standard candle luminosity functions. A chi-square analysis is used to estimate the goodness of the fits and the author derives the significance level of limits on the density evolution and luminosity function parameters. Cosmological models provide a good fit over a range of parameter space which is physically reasonable

  13. Bursts de raios gama

    Science.gov (United States)

    Braga, J.

    2003-02-01

    Nos últimos anos, graças principalmente aos dados obtidos pelo Compton Gamma-Ray Observatory e pelo satélite ítalo-holandês BeppoSAX, grandes avanços foram obtidos no nosso conhecimento sobre os fascinantes e enigmáticos fenômenos conhecidos por "bursts"de raios gama. Neste trabalho é feita uma revisão sobre a fenomenologia desses misteriosos objetos e são apresentados os desenvolvimentos recentes nessa área palpitante da astrofísica moderna, ressaltando tanto os resultados observacionais obtidos até o momento quanto os modelos teóricos propostos para explixá-los.

  14. Suppressive effect of paroxetine, a selective serotonin uptake inhibitor, on tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice.

    Science.gov (United States)

    Miura, Hideki; Kitagami, Tomitsune; Ozaki, Norio

    2007-09-01

    Tetrahydrobiopterin (BH(4)) is a coenzyme of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), which are rate-limiting enzymes of monoamine biosynthesis. According to the monoamine hypothesis of depression, antidepressants will restore the function of the brain monoaminergic system and the BH(4) concentration. In the present study, we investigated the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on the BH(4) levels and dopamine (DA) and serotonin (5-HT) turnover in the mesoprefrontal system, incorporating two risk factors of depression, social isolation and acute environmental change. Male ddY mice (8W) were divided into two housing groups, i.e., group-housing (eight animals per cage; 28 days), and isolation-housing (one per cage; 28 days), being p.o.-administered paroxetine (5 or 10 mg/kg; days 15-28), and exposed to a 20-min novelty stress (day 28). The levels of BH(4), DA, homovanilic acid (HVA), 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the prefrontal cortex and midbrain. In both the regions, novelty stress significantly increased BH(4) levels under the isolation-housing condition, whereas these levels were decreased under the group-housing condition. Thus, social isolation altered the neurochemical response to novelty stress. Paroxetine significantly decreased BH(4) levels under the isolation-housing condition, whereas decreased HVA/DA and 5-HIAA/5-HT ratios were observed under the group-housing condition. Thus, social isolation may have influenced the suppressive effects of paroxetine on BH(4) levels as well as exerted an influence on DA and 5-HT turnover. We replicated our recent findings that SSRI, fluvoxamine, suppressed BH(4) levels, as well as DA and 5-HT turnover in the mouse mesoprefrontal system.

  15. Type I X-ray bursts and burst oscillations in the accreting millisecond X-ray pulsar IGR J17511-3057

    CERN Document Server

    Altamirano, D; Linares, M; Markwardt, C B; Strohmayer, T; Patruno, A

    2010-01-01

    We report the discovery of burst oscillations at the spin frequency in ten thermonuclear bursts from the accreting millisecond X-ray pulsar (AMXP) IGR J17511-3057. The burst oscillation properties are, like those from the AMXPs SAX J1808.4-3658 and XTE J1814-338, anomalous compared to burst oscillations from intermittent pulsars or non-pulsing LMXBs. Like SAX J1808.4-3658 they show frequency drifts in the rising phase rather than the tail. There is also evidence for harmonic content. Where IGR J17511-3057 is unusual compared to the other pulsars is that oscillations are not detected throughout all bursts. As accretion rate drops the bursts get brighter and their rise/decay time scales become shorter, while the oscillation amplitude falls below the detection threshold: first in the burst peak and then also in the rise. None of the bursts from IGR J17511-3057 show evidence for photospheric radius expansion (which might be expected to suppress oscillation amplitude) which allow us to set an upper limit to the di...

  16. Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially?

    Directory of Open Access Journals (Sweden)

    Dirk De Ridder, Elsa van der Loo, Karolien Van der Kelen, Tomas Menovsky, Paul van de Heyning, Aage Moller

    2007-01-01

    Full Text Available Introduction: Tinnitus is an auditory phantom percept related to tonic and burst hyperactivity of the auditory system. Two parallel pathways supply auditory information to the cerebral cortex: the tonotopically organised lemniscal system, and the non-tonotopic extralemniscal system, firing in tonic mode and burst mode respectively. Transcranial magnetic stimulation (TMS is a non-invasive method capable of modulating activity of the human cortex, by delivering tonic or burst stimuli. Burst stimulation is shown to be more powerful in activating the cerebral cortex than tonic stimulation and bursts may activate neurons that are not activated by tonic stimulations. Methods: The effect of both tonic and burst TMS in 14 placebo-negative patients presenting narrow band/white noise tinnitus were analysed. Results: Our TMS results show that narrow band/white noise tinnitus is better suppressed with burst TMS in comparison to tonic TMS, t(13=6.4, p=.000. For pure tone tinnitus no difference is found between burst or tonic TMS, t(13=.3, ns. Discussion: Based on the hypothesis that white noise is the result of hyperactivity in the non-tonotopic system and pure tone tinnitus of the tonotopic system, we suggest that burst stimulation modulates the extralemniscal system and lemniscal system and tonic stimulation only the lemniscal system.

  17. Behaviorally relevant burst coding in primary sensory neurons.

    Science.gov (United States)

    Sabourin, Patrick; Pollack, Gerald S

    2009-08-01

    Bursts of action potentials in sensory interneurons are believed to signal the occurrence of particularly salient stimulus features. Previous work showed that bursts in an identified, ultrasound-tuned interneuron (AN2) of the cricket Teleogryllus oceanicus code for conspicuous increases in amplitude of an ultrasound stimulus, resulting in behavioral responses that are interpreted as avoidance of echolocating bats. We show that the primary sensory neurons that inform AN2 about high-frequency acoustic stimuli also produce bursts. As is the case for AN2, bursts in sensory neurons perform better as feature detectors than isolated, nonburst, spikes. Bursting is temporally correlated between sensory neurons, suggesting that on occurrence of a salient stimulus feature, AN2 will receive strong synaptic input in the form of coincident bursts, from several sensory neurons, and that this might result in bursting in AN2. Our results show that an important feature of the temporal structure of interneuron spike trains can be established at the earliest possible level of sensory processing, i.e., that of the primary sensory neuron.

  18. Observing a Burst with Sunglasses

    Science.gov (United States)

    2003-11-01

    astronomers therefore turned to the powerful multi-mode FORS1 instrument on the VLT ANTU telescope. They obtained 31 polarimetric observations over a period of 38 days, enabling them to measure, for the first time , the changes of the polarisation of an optical gamma-ray burst afterglow with time. This unique set of observational data documents the physical changes in the remote object in unsurpassed detail. Their data show the presence of polarisation at the level of 0.3 to 2.5 % throughout the 38-day period with significant variability in strength and orientation on timescales down to hours. This particular behaviour has not been predicted by any of the major theories. Unfortunately, the very complex light curve of this GRB afterglow, in itself not understood, prevents a straightforward application of existing polarisation models. " It turns out that deriving the direction of the jet and the magnetic field structure is not as simple as we thought originally ", notes Olaf Reimer , another member of the team. " But the rapid changes of the polarisation properties, even during smooth phases of the afterglow light curve, provide a challenge to afterglow theory ". " Possibly ", adds Jochen Greiner , " the overall low level of polarisation indicates that the strength of the magnetic field in the parallel and perpendicular directions do not differ by more than 10%, thus suggesting a field strongly coupled with the moving material. This is different from the large-scale field which is left-over from the exploding star and which is thought to produce the high-level of polarisation in the gamma-rays. " More Information The research described in this Press Release will appear under the title " The evolution of the polarisation of the afterglow of GRB 030329 " by Jochen Greiner et al. in the November 13, 2003 issue of the science journal "Nature". A German translation of the information of this page can be found at Astronomie.de. Notes [1]: In astronomy, the "redshift" denotes the

  19. Determination of ejection velocity of rock fragments during rock burst in consideration of damage

    Institute of Scientific and Technical Information of China (English)

    ZUO Yu-jun; LI Xi-bing; ZHOU Zi-long

    2005-01-01

    The ejection velocity of rock fragments during rock burst, one of the important indexes representing the rock burst strength, is used most conveniently in the supporting design of tunnel with rock burst tendency and is often determined by means of observation devices. In order to calculate the average ejection velocity of rock fragments theoretically, the energy of rock burst was divided into damage consuming energy and kinetic energy gained by unit volume of rock firstly, and then the rock burst kinetic proportional coefficient η was brought up which could be determined according to the rock-burst damage energy index WD , at last the expression of the average ejection velocity of rock fragments during rock burst was obtained and one deep level underground tunnel was researched using the mentioned method. The results show that the calculation method is valid with or without considering the tectonic stress of tunnels, and that the method can be a reference for supporting design of deep mining.

  20. Emergent synchronous bursting of oxytocin neuronal network.

    Directory of Open Access Journals (Sweden)

    Enrico Rossoni

    Full Text Available When young suckle, they are rewarded intermittently with a let-down of milk that results from reflex secretion of the hormone oxytocin; without oxytocin, newly born young will die unless they are fostered. Oxytocin is made by magnocellular hypothalamic neurons, and is secreted from their nerve endings in the pituitary in response to action potentials (spikes that are generated in the cell bodies and which are propagated down their axons to the nerve endings. Normally, oxytocin cells discharge asynchronously at 1-3 spikes/s, but during suckling, every 5 min or so, each discharges a brief, intense burst of spikes that release a pulse of oxytocin into the circulation. This reflex was the first, and is perhaps the best, example of a physiological role for peptide-mediated communication within the brain: it is coordinated by the release of oxytocin from the dendrites of oxytocin cells; it can be facilitated by injection of tiny amounts of oxytocin into the hypothalamus, and it can be blocked by injection of tiny amounts of oxytocin antagonist. Here we show how synchronized bursting can arise in a neuronal network model that incorporates basic observations of the physiology of oxytocin cells. In our model, bursting is an emergent behaviour of a complex system, involving both positive and negative feedbacks, between many sparsely connected cells. The oxytocin cells are regulated by independent afferent inputs, but they interact by local release of oxytocin and endocannabinoids. Oxytocin released from the dendrites of these cells has a positive-feedback effect, while endocannabinoids have an inhibitory effect by suppressing the afferent input to the cells.

  1. D-Dimer Levels before HIV Seroconversion Remain Elevated Even after Viral Suppression and Are Associated with an Increased Risk of Non-AIDS Events.

    Science.gov (United States)

    Freiberg, Matthew S; Bebu, Ionut; Tracy, Russell; So-Armah, Kaku; Okulicz, Jason; Ganesan, Anuradha; Armstrong, Adam; O'Bryan, Thomas; Rimland, David; Justice, Amy C; Agan, Brian K

    2016-01-01

    The mechanism underlying the excess risk of non-AIDS diseases among HIV infected people is unclear. HIV associated inflammation/hypercoagulability likely plays a role. While antiretroviral therapy (ART) may return this process to pre-HIV levels, this has not been directly demonstrated. We analyzed data/specimens on 249 HIV+ participants from the US Military HIV Natural History Study, a prospective, multicenter observational cohort of >5600 active duty military personnel and beneficiaries living with HIV. We used stored blood specimens to measure D-dimer and Interleukin-6 (IL-6) at three time points: pre-HIV seroconversion, ≥6 months post-HIV seroconversion but prior to ART initiation, and ≥6 months post-ART with documented HIV viral suppression on two successive evaluations. We evaluated the changes in biomarker levels between time points, and the association between these biomarker changes and future non-AIDS events. During a median follow-up of 3.7 years, there were 28 incident non-AIDS diseases. At ART initiation, the median CD4 count was 361cells/mm3; median duration of documented HIV infection 392 days; median time on ART was 354 days. Adjusted mean percent increase in D-dimer levels from pre-seroconversion to post-ART was 75.1% (95% confidence interval 24.6-148.0, p = 0.002). This increase in D-dimer was associated with a significant 22% increase risk of future non-AIDS events (p = 0.03). Changes in IL-6 levels across time points were small and not associated with future non-AIDS events. In conclusion, ART initiation and HIV viral suppression does not eliminate HIV associated elevation in D-dimer levels. This residual pathology is associated with an increased risk of future non-AIDS diseases.

  2. Coherence resonance in bursting neural networks.

    Science.gov (United States)

    Kim, June Hoan; Lee, Ho Jun; Min, Cheol Hong; Lee, Kyoung J

    2015-10-01

    Synchronized neural bursts are one of the most noticeable dynamic features of neural networks, being essential for various phenomena in neuroscience, yet their complex dynamics are not well understood. With extrinsic electrical and optical manipulations on cultured neural networks, we demonstrate that the regularity (or randomness) of burst sequences is in many cases determined by a (few) low-dimensional attractor(s) working under strong neural noise. Moreover, there is an optimal level of noise strength at which the regularity of the interburst interval sequence becomes maximal-a phenomenon of coherence resonance. The experimental observations are successfully reproduced through computer simulations on a well-established neural network model, suggesting that the same phenomena may occur in many in vivo as well as in vitro neural networks.

  3. Suppression of spore germination and aflatoxin biosynthesis in Aspergillus parasiticus during and after exposure to high levels of phosphine.

    Science.gov (United States)

    Antonacci, L; Salvat, A E; Faifer, G C; Godoy, H M

    1999-01-01

    Agar cultures of toxigenic Aspergillus parasiticus NRRL 2999 were exposed to phosphine (PH3), in levels ranging from 0 to 2000 ppm (vol/vol). It was found that with PH3 concentrations of 400 ppm or higher the growth of the fungus was totally arrested. When PH3 was vented and the agar plates were exposed to open air, 100% of the initial CFU developed into fully grown colonies after PH3 levels below 300 ppm, but at higher PH3 concentrations only 50% of the colonies developed. The same strain of A. parasiticus was inoculated into high moisture corn under conditions highly favorable for aflatoxin production, and it was exposed to a range of PH3 levels. After exposure to 500 ppm PH3, both fungal growth and aflatoxin synthesis resumed shortly after elimination of the toxic gas, but after exposure to PH3 levels of 1000 ppm and higher, the physical appearance of the contaminated corn was remarkably changed, showing reduced mycelial growth and almost complete absence of green pigmentation. In addition, aflatoxin synthesis was totally absent for the remainder of the experiment (20 days). These results strongly suggest that exposure to PH3 levels of 1000 ppm or higher could bring about persistent metabolic changes in surviving Aspergillus organisms.

  4. 30 CFR 57.3461 - Rock bursts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Rock bursts. 57.3461 Section 57.3461 Mineral...-Underground Only § 57.3461 Rock bursts. (a) Operators of mines which have experienced a rock burst shall— (1) Within twenty four hours report to the nearest MSHA office each rock burst which: (i) Causes persons...

  5. Gamma-ray burst models.

    Science.gov (United States)

    King, Andrew

    2007-05-15

    I consider various possibilities for making gamma-ray bursts, particularly from close binaries. In addition to the much-studied neutron star+neutron star and black hole+neutron star cases usually considered good candidates for short-duration bursts, there are also other possibilities. In particular, neutron star+massive white dwarf has several desirable features. These systems are likely to produce long-duration gamma-ray bursts (GRBs), in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation and occur close to the host galaxy. However, rare members of the class need not be near star-forming regions and could have any type of host galaxy. Thus, a long-duration burst far from any star-forming region would also be a signature of this class. Estimates based on the existence of a known progenitor suggest that this type of GRB may be quite common, in agreement with the fact that the absence of a supernova can only be established in nearby bursts.

  6. RNA interference (RNAi)-induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves.

    Science.gov (United States)

    Lewis, Ramsey S; Jack, Anne M; Morris, Jerry W; Robert, Vincent J M; Gavilano, Lily B; Siminszky, Balazs; Bush, Lowell P; Hayes, Alec J; Dewey, Ralph E

    2008-05-01

    Technologies for reducing the levels of tobacco product constituents that may contribute to unwanted health effects are desired. Target compounds include tobacco-specific nitrosamines (TSNAs), a class of compounds generated through the nitrosation of pyridine alkaloids during the curing and processing of tobacco. Studies have reported the TSNA N'-nitrosonornicotine (NNN) to be carcinogenic in laboratory animals. NNN is formed via the nitrosation of nornicotine, a secondary alkaloid produced through enzymatic N-demethylation of nicotine. Strategies to lower nornicotine levels in tobacco (Nicotiana tabacum L.) could lead to a corresponding decrease in NNN accumulation in cured leaves. The major nicotine demethylase gene of tobacco has recently been isolated. In this study, a large-scale field trial was conducted to evaluate transgenic lines of burley tobacco carrying an RNA interference (RNAi) construct designed to inhibit the expression of this gene. Selected transgenic lines exhibited a six-fold decrease in nornicotine content relative to untransformed controls. Analysis of cured leaves revealed a commensurate decrease in NNN and total TSNAs. The inhibition of nicotine demethylase activity is an effective means of decreasing significantly the level of a key defined animal carcinogen present in tobacco products.

  7. Do Gamma-Ray Burst Sources Repeat?

    OpenAIRE

    Meegan, Charles A.; Hartmann, Dieter H.; Brainerd, J. J.; Briggs, Michael S.; Paciesas, William S.; Pendleton, Geoffrey; Kouveliotou, Chryssa; Fishman, Gerald; Blumenthal, George; Brock, Martin

    1995-01-01

    The demonstration of repeated gamma-ray bursts from an individual source would severely constrain burst source models. Recent reports (Quashnock and Lamb 1993; Wang and Lingenfelter 1993) of evidence for repetition in the first BATSE burst catalog have generated renewed interest in this issue. Here, we analyze the angular distribution of 585 bursts of the second BATSE catalog (Meegan et al. 1994). We search for evidence of burst recurrence using the nearest and farthest neighbor statistic and...

  8. Suppressed Belief

    Directory of Open Access Journals (Sweden)

    Komarine Romdenh-Romluc

    2009-12-01

    Full Text Available Moran’s revised conception of conscious belief requires us to reconceptualise suppressed belief. The work of Merleau-Ponty offers a way to do this. His account of motor-skills allows us to understand suppressed beliefs as pre-reflective ways of dealing with the world.

  9. Optimal control of quantum gates and suppression of decoherence in a system of interacting two-level particles

    CERN Document Server

    Grace, M; Kosut, R L; Lidar, D A; Rabitz, H; Walmsley, I A; Brif, Constantin; Grace, Matthew; Kosut, Robert L.; Lidar, Daniel A.; Rabitz, Herschel; Walmsley, Ian A.

    2007-01-01

    Methods of optimal control are applied to a model system of interacting two-level particles (e.g., spin-half atomic nuclei or electrons or two-level atoms) to produce high-fidelity quantum gates while simultaneously negating the detrimental effect of decoherence. One set of particles functions as the quantum information processor, whose evolution is controlled by a time-dependent external field. The other particles are not directly controlled and serve as an effective environment, coupling to which is the source of decoherence. The control objective is to generate target one- and two-qubit unitary gates in the presence of strong environmentally-induced decoherence and under physically motivated restrictions on the control field. The quantum-gate fidelity, expressed in terms of a novel state-independent distance measure, is maximized with respect to the control field using combined genetic and gradient algorithms. The resulting high-fidelity gates demonstrate the feasibility of precisely guiding the quantum ev...

  10. Serotonin 2A receptor mRNA levels in the neonatal dopamine-depleted rat striatum remain upregulated following suppression of serotonin hyperinnervation.

    Science.gov (United States)

    Basura, G J; Walker, P D

    1999-08-05

    Sixty days after bilateral dopamine (DA) depletion (>98%) with 6-hydroxydopamine (6-OHDA) in neonatal rats, serotonin (5-HT) content doubled and 5-HT(2A) receptor mRNA expression rose 54% within the rostral striatum. To determine if striatal 5-HT(2A) receptor mRNA upregulation is dependent on increased 5-HT levels following DA depletion, neonatal rats received dual injections of 6-OHDA and 5,7-dihydroxytryptamine (5,7-DHT) which suppressed 5-HT content by approximately 90%. In these 6-OHDA/5,7-DHT-treated rats, striatal 5-HT(2A) receptor mRNA expression was still elevated (87% above vehicle controls). Comparative analysis of 5-HT(2C) receptor mRNA expression yielded no significant changes in any experimental group. These results demonstrate that upregulated 5-HT(2A) receptor biosynthesis in the DA-depleted rat is not dependent on subsequent 5-HT hyperinnervation.

  11. A Retroactive-Burst Framework for Automated Intrusion Response System

    Directory of Open Access Journals (Sweden)

    Alireza Shameli-Sendi

    2013-01-01

    Full Text Available The aim of this paper is to present an adaptive and cost-sensitive model to prevent security intrusions. In most automated intrusion response systems, response selection is performed locally based on current threat without using the knowledge of attacks history. Another challenge is that a group of responses are applied without any feedback mechanism to measure the response effect. We address these problems through retroactive-burst execution of responses and a Response Coordinator (RC mechanism, the main contributions of this work. The retroactive-burst execution consists of several burst executions of responses with, at the end of each burst, a mechanism for measuring the effectiveness of the applied responses by the risk assessment component. The appropriate combination of responses must be considered for each burst execution to mitigate the progress of the attack without necessarily running the next round of responses, because of the impact on legitimate users. In the proposed model, there is a multilevel response mechanism. To indicate which level is appropriate to apply based on the retroactive-burst execution, we get help from a Response Coordinator mechanism. The applied responses can improve the health of Applications, Kernel, Local Services, Network Services, and Physical Status. Based on these indexes, the RC gives a general overview of an attacker’s goal in a distributed environment.

  12. Hard X-rays and associated weak decimetric bursts

    Science.gov (United States)

    Sawant, H. S.; Lattari, C. J. B.; Benz, A. O.; Dennis, B. R.

    1990-01-01

    Results are presented of observations (made with the Hard X-Ray Burst Spectrometer on the SMM and with the Itapetinga antenna) that unambiguously show associations of hard X-ray bursts with RS-type III bursts between 16:46 UT and 16:52 UT on July 9, 1985. The comparison between the hard X-ray and the radio observations shows a clear association, in at least 13 cases, of the hard X-ray and the decimetric RS bursts. On the average, the X-ray peaks were delayed from the peak of the RS bursts at 1.6 Ghz by about 400 msec. It is shown that, if the time comparisons are made between the peak of the radio pulse and the start of the X-ray burst, the delays are consistent with an electron travel time with a velocity of about 0.3 c from the 800 MHz plasma level to the lower corona, assuming that the radio emission is at the second harmonic.

  13. The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease.

    Science.gov (United States)

    Tinkhauser, Gerd; Pogosyan, Alek; Little, Simon; Beudel, Martijn; Herz, Damian M; Tan, Huiling; Brown, Peter

    2017-02-13

    Adaptive deep brain stimulation uses feedback about the state of neural circuits to control stimulation rather than delivering fixed stimulation all the time, as currently performed. In patients with Parkinson's disease, elevations in beta activity (13-35 Hz) in the subthalamic nucleus have been demonstrated to correlate with clinical impairment and have provided the basis for feedback control in trials of adaptive deep brain stimulation. These pilot studies have suggested that adaptive deep brain stimulation may potentially be more effective, efficient and selective than conventional deep brain stimulation, implying mechanistic differences between the two approaches. Here we test the hypothesis that such differences arise through differential effects on the temporal dynamics of beta activity. The latter is not constantly increased in Parkinson's disease, but comes in bursts of different durations and amplitudes. We demonstrate that the amplitude of beta activity in the subthalamic nucleus increases in proportion to burst duration, consistent with progressively increasing synchronization. Effective adaptive deep brain stimulation truncated long beta bursts shifting the distribution of burst duration away from long duration with large amplitude towards short duration, lower amplitude bursts. Critically, bursts with shorter duration are negatively and bursts with longer duration positively correlated with the motor impairment off stimulation. Conventional deep brain stimulation did not change the distribution of burst durations. Although both adaptive and conventional deep brain stimulation suppressed mean beta activity amplitude compared to the unstimulated state, this was achieved by a selective effect on burst duration during adaptive deep brain stimulation, whereas conventional deep brain stimulation globally suppressed beta activity. We posit that the relatively selective effect of adaptive deep brain stimulation provides a rationale for why this approach could

  14. Active suppression of early immune response in tobacco by the human pathogen Salmonella Typhimurium.

    Directory of Open Access Journals (Sweden)

    Natali Shirron

    Full Text Available The persistence of enteric pathogens on plants has been studied extensively, mainly due to the potential hazard of human pathogens such as Salmonella enterica being able to invade and survive in/on plants. Factors involved in the interactions between enteric bacteria and plants have been identified and consequently it was hypothesized that plants may be vectors or alternative hosts for enteric pathogens. To survive, endophytic bacteria have to escape the plant immune systems, which function at different levels through the plant-bacteria interactions. To understand how S. enterica survives endophyticaly we conducted a detailed analysis on its ability to elicit or evade the plant immune response. The models of this study were Nicotiana tabacum plants and cells suspension exposed to S. enterica serovar Typhimurium. The plant immune response was analyzed by looking at tissue damage and by testing oxidative burst and pH changes. It was found that S. Typhimurium did not promote disease symptoms in the contaminated plants. Live S. Typhimurium did not trigger the production of an oxidative burst and pH changes by the plant cells, while heat killed or chloramphenicol treated S. Typhimurium and purified LPS of Salmonella were significant elicitors, indicating that S. Typhimurium actively suppress the plant response. By looking at the plant response to mutants defective in virulence factors we showed that the suppression depends on secreted factors. Deletion of invA reduced the ability of S. Typhimurium to suppress oxidative burst and pH changes, indicating that a functional SPI1 TTSS is required for the suppression. This study demonstrates that plant colonization by S. Typhimurium is indeed an active process. S. Typhimurium utilizes adaptive strategies of altering innate plant perception systems to improve its fitness in the plant habitat. All together these results suggest a complex mechanism for perception of S. Typhimurium by plants.

  15. Broadband Spectral Study of Magnetar Bursts

    Science.gov (United States)

    Kirmizibayrak, Demet; Gogus, Ersin; Sasmaz Mus, Sinem; Kaneko, Yuki

    2016-07-01

    Magnetar bursts occur sporadically on random occasions, and every burst-active episode carries unique information about the bursting magnetar. Therefore, in-depth spectral and temporal analyses of each of the magnetar bursts provide new insights into the bursting and radiation mechanisms. There have been a number of studies over the last decade, investigating the spectral and temporal properties of magnetar bursts. The spectra of typical magnetar bursts were generally described with the Comptonized model or the sum of two blackbody functions. However, it was recently shown that the actual spectral nature of these bursts can be conclusively determined if the spectral analysis is performed on a wide energy coverage. We present the results of in-depth systematic broadband (2 - 250 keV) spectral analysis of a large number of bursts originated from three magnetars: SGR 1806-20, SGR 1900+14, and SGR J1550-5418, observed with the Rossi X-ray Timing Explorer.

  16. Prognostic value of non-reactive burst suppression EEG pattern associated to early neonatal seizures Valor prognóstico do EEG com padrão de surto-supressão não reativo associado a convulsões neonatais precoces

    Directory of Open Access Journals (Sweden)

    Magda Lahorgue Nunes

    2005-03-01

    Full Text Available ABSTRACT Seizures are the most frequent neurological event in newborns and clinical data suggest that etiology is the dominant factor in long term outcome. However, there are consistent background EEG abnormalities associated to neonatal seizures that are usually related to unfavorable outcome as the burst - suppression pattern. OBJECTIVE: The objective of this study was to correlate clinical and EEG features associated to long - term outcome of newborns with non - reactive burst - suppression (BS EEG. METHOD: Newborns included in the study were selected from our database and had conceptional age (at the time of first EEG >37 weeks, EEG recordings with non - reactive BS available for review and clinical follow up. RESULTS: 12 newborns met inclusion criteria, 50% had seizures in the first day of life. Seizures became refractory to treatment in all of them. In 50% the etiology of seizures was considered cryptogenic, 33% had inborn errors of metabolism and 17% had clinical history and neuroimage suggestive of hypoxic-ischemic encephalopathy. The follow-up showed that 7/12 infants deceased, 3 during the first year of life, and one in the neonatal period. All the survivors had severe developmental delay and multifocal neurological impairment. 92% developed refractory epilepsy, 58% were latter diagnosed with West syndrome. CONCLUSION: The non-reactive BS pattern may appear related to many neonatal neurological disorders and is associated with early and refractory neonatal seizures. It is clearly associated with elevated morbidity and mortality and to the development of post-neonatal epilepsy.RESUMO Convulsões representam o evento neurológico mais freqüente no período neonatal e a etiologia das crises parece ser o aspecto clínico mais associado ao prognóstico a longo prazo. Entretanto, existem padrões anormais de EEG, que de forma consistente relacionam-se a prognóstico, entre eles o padrão de surto - supressão. OBJETIVO: Este estudo teve

  17. Amplitude-Modulated Bursting: A Novel Class of Bursting Rhythms

    Science.gov (United States)

    Vo, Theodore; Kramer, Mark A.; Kaper, Tasso J.

    2016-12-01

    We report on the discovery of a novel class of bursting rhythms, called amplitude-modulated bursting (AMB), in a model for intracellular calcium dynamics. We find that these rhythms are robust and exist on open parameter sets. We develop a new mathematical framework with broad applicability to detect, classify, and rigorously analyze AMB. Here we illustrate this framework in the context of AMB in a model of intracellular calcium dynamics. In the process, we discover a novel family of singularities, called toral folded singularities, which are the organizing centers for the amplitude modulation and exist generically in slow-fast systems with two or more slow variables.

  18. Intramuscular depot formulations of leuprolide acetate suppress testosterone levels below a 20 ng/dL threshold: a retrospective analysis of two Phase III studies

    Directory of Open Access Journals (Sweden)

    Spitz A

    2016-08-01

    Full Text Available Aaron Spitz,1 Marc Gittelman,2 Lawrence I Karsh,3 Sanja Dragnic,4 Ahmed M Soliman,5 Aditya Lele,6 Damian Gruca,7 Michael Norton4 1Orange County Urology Associates, Laguna Beach, CA, 221st Century Oncology/UroMedix-Aventura Division, Aventura, FL, 3The Urology Center of Colorado, Denver, CO, 4US Medical Affairs, 5Health Economics and Outcomes Research, 6Data and Statistical Sciences, AbbVie Inc., North Chicago, IL, USA; 7Global Medical Affairs, AbbVie Deutschland, Ludwigshafen, Germany Introduction: Androgen deprivation therapy (ADT with gonadotropin-releasing hormone (GnRH analogs is a standard treatment for advanced prostate cancer. GnRH analog therapy can reduce testosterone to “castrate” levels, historically defined as <50 ng/dL. With the advent of newer assays, a lower threshold of <20 ng/dL has recently been proposed. We report the results of a retrospective analysis of two Phase III trials of 4- and 6-month depot microsphere formulations of leuprolide acetate (LA, a GnRH agonist that has previously demonstrated efficacy in testosterone suppression to <50 ng/dL in patients on ADT. This analysis investigates the ability of these LA formulations to suppress to ≤20 ng/dL levels.Methods: In two of five AbbVie/Abbott clinical trials of microsphere formulations of LA for ADT, analytic technology permitting testosterone detection as low as 3 ng/dL was used and thus was selected for this analysis. Both trials were open-label, fixed-dose studies in prostate cancer patients, naïve to ADT. Patients received either 30 mg (4-month formulation; n=49 or 45 mg (6-month formulation; n=151 depot injections of LA microspheres. Treatment duration was up to 32 weeks for the 4-month formulation and 48 weeks for the 6-month formulation. The proportion of patients achieving the 20 ng/dL threshold was determined every 4 weeks.Results: Pooled analysis showed that 152 of 193 (79% of patients achieved serum testosterone levels of ≤20 ng/dL at 4 weeks, and

  19. Bursts in intermittent aeolian saltation

    CERN Document Server

    Carneiro, M V; Herrmann, H J

    2014-01-01

    Close to the onset of Aeolian particle transport through saltation we find in wind tunnel experiments a regime of intermittent flux characterized by bursts of activity. Scaling laws are observed in the time delay between each burst and in the measurements of the wind fluctuations at the critical Shields number $\\theta_c$. The time delay between each burst decreases on average with the increase of the Shields number until saltation becomes non-intermittent and the sand flux becomes continuous. A numerical model for saltation including the wind-entrainment from the turbulent fluctuations can reproduce these observations and gives insight about their origin. We present here also for the first time measurements showing that with feeding it becomes possible to sustain intermittent flux even below the threshold $\\theta_c$ for natural saltation initiation.

  20. Detection of artifacts from high energy bursts in neonatal EEG.

    Science.gov (United States)

    Bhattacharyya, Sourya; Biswas, Arunava; Mukherjee, Jayanta; Majumdar, Arun Kumar; Majumdar, Bandana; Mukherjee, Suchandra; Singh, Arun Kumar

    2013-11-01

    Detection of non-cerebral activities or artifacts, intermixed within the background EEG, is essential to discard them from subsequent pattern analysis. The problem is much harder in neonatal EEG, where the background EEG contains spikes, waves, and rapid fluctuations in amplitude and frequency. Existing artifact detection methods are mostly limited to detect only a subset of artifacts such as ocular, muscle or power line artifacts. Few methods integrate different modules, each for detection of one specific category of artifact. Furthermore, most of the reference approaches are implemented and tested on adult EEG recordings. Direct application of those methods on neonatal EEG causes performance deterioration, due to greater pattern variation and inherent complexity. A method for detection of a wide range of artifact categories in neonatal EEG is thus required. At the same time, the method should be specific enough to preserve the background EEG information. The current study describes a feature based classification approach to detect both repetitive (generated from ECG, EMG, pulse, respiration, etc.) and transient (generated from eye blinking, eye movement, patient movement, etc.) artifacts. It focuses on artifact detection within high energy burst patterns, instead of detecting artifacts within the complete background EEG with wide pattern variation. The objective is to find true burst patterns, which can later be used to identify the Burst-Suppression (BS) pattern, which is commonly observed during newborn seizure. Such selective artifact detection is proven to be more sensitive to artifacts and specific to bursts, compared to the existing artifact detection approaches applied on the complete background EEG. Several time domain, frequency domain, statistical features, and features generated by wavelet decomposition are analyzed to model the proposed bi-classification between burst and artifact segments. A feature selection method is also applied to select the

  1. Spikes and bursts in two types of thalamic projection neurons differentially shape sleep patterns and auditory responses in a songbird.

    Science.gov (United States)

    Hahnloser, Richard H R; Wang, Claude Z-H; Nager, Aymeric; Naie, Katja

    2008-05-07

    In mammals, the thalamus plays important roles for cortical processing, such as relay of sensory information and induction of rhythmical firing during sleep. In neurons of the avian cerebrum, in analogy with cortical up and down states, complex patterns of regular-spiking and dense-bursting modes are frequently observed during sleep. However, the roles of thalamic inputs for shaping these firing modes are largely unknown. A suspected key player is the avian thalamic nucleus uvaeformis (Uva). Uva is innervated by polysensory input, receives indirect cerebral feedback via the midbrain, and projects to the cerebrum via two distinct pathways. Using pharmacological manipulation, electrical stimulation, and extracellular recordings of Uva projection neurons, we study the involvement of Uva in zebra finches for the generation of spontaneous activity and auditory responses in premotor area HVC (used as a proper name) and the downstream robust nucleus of the arcopallium (RA). In awake and sleeping birds, we find that single Uva spikes suppress and spike bursts enhance spontaneous and auditory-evoked bursts in HVC and RA neurons. Strong burst suppression is mediated mainly via tonically firing HVC-projecting Uva neurons, whereas a fast burst drive is mediated indirectly via Uva neurons projecting to the nucleus interface of the nidopallium. Our results reveal that cerebral sleep-burst epochs and arousal-related burst suppression are both shaped by sophisticated polysynaptic thalamic mechanisms.

  2. High levels of adherence and viral suppression in a nationally representative sample of HIV-infected adults on antiretroviral therapy for 6, 12 and 18 months in Rwanda.

    Directory of Open Access Journals (Sweden)

    Batya Elul

    Full Text Available BACKGROUND: Generalizable data are needed on the magnitude and determinants of adherence and virological suppression among patients on antiretroviral therapy (ART in Africa. METHODS: We conducted a cross-sectional survey with chart abstraction, patient interviews and site assessments in a nationally representative sample of adults on ART for 6, 12 and 18 months at 20 sites in Rwanda. Adherence was assessed using 3- and 30-day patient recall. A systematically selected sub-sample had viral load (VL measurements. Multivariable logistic regression examined predictors of non-perfect (40 copies/ml. RESULTS: Overall, 1,417 adults were interviewed and 837 had VL measures. Ninety-four percent and 78% reported perfect adherence for the last 3 and 30 days, respectively. Eighty-three percent had undetectable VL. In adjusted models, characteristics independently associated with higher odds of non-perfect 30-day adherence were: being on ART for 18 months (vs. 6 months; younger age; reporting severe (vs. no or few side effects in the prior 30 days; having no documentation of CD4 cell count at ART initiation (vs. having a CD4 cell count of <200 cells/µL; alcohol use; and attending sites which initiated ART services in 2003-2004 and 2005 (vs. 2006-2007; sites with ≥600 (vs. <600 patients on ART; or sites with peer educators. Participation in an association for people living with HIV/AIDS; and receiving care at sites which regularly conduct home-visits were independently associated with lower odds of non-adherence. Higher odds of having a detectable VL were observed among patients at sites with peer educators. Being female; participating in an association for PLWHA; and using a reminder tool were independently associated with lower odds of having detectable VL. CONCLUSIONS: High levels of adherence and viral suppression were observed in the Rwandan national ART program, and associated with potentially modifiable factors.

  3. High Redshift Gamma Ray Bursts

    Science.gov (United States)

    Gehrels, Neil

    2012-01-01

    The Swift Observatory has been detecting 100 gamma-ray bursts per year for 7 years and has greatly stimulated the field with new findings. Observations are made of the X-ray and optical afterglow from 1 minute after the burst, continuing for days. GRBs are providing a new tool to study the high redshift universe. Swift has detected several events at z>5 and one at z=9.4 giving information on metallicity, star formation rate and reionization. The talk will present the latest results.

  4. Thalamic neuron models encode stimulus information by burst-size modulation.

    Science.gov (United States)

    Elijah, Daniel H; Samengo, Inés; Montemurro, Marcelo A

    2015-01-01

    Thalamic neurons have been long assumed to fire in tonic mode during perceptive states, and in burst mode during sleep and unconsciousness. However, recent evidence suggests that bursts may also be relevant in the encoding of sensory information. Here, we explore the neural code of such thalamic bursts. In order to assess whether the burst code is generic or whether it depends on the detailed properties of each bursting neuron, we analyzed two neuron models incorporating different levels of biological detail. One of the models contained no information of the biophysical processes entailed in spike generation, and described neuron activity at a phenomenological level. The second model represented the evolution of the individual ionic conductances involved in spiking and bursting, and required a large number of parameters. We analyzed the models' input selectivity using reverse correlation methods and information theory. We found that n-spike bursts from both models transmit information by modulating their spike count in response to changes to instantaneous input features, such as slope, phase, amplitude, etc. The stimulus feature that is most efficiently encoded by bursts, however, need not coincide with one of such classical features. We therefore searched for the optimal feature among all those that could be expressed as a linear transformation of the time-dependent input current. We found that bursting neurons transmitted 6 times more information about such more general features. The relevant events in the stimulus were located in a time window spanning ~100 ms before and ~20 ms after burst onset. Most importantly, the neural code employed by the simple and the biologically realistic models was largely the same, implying that the simple thalamic neuron model contains the essential ingredients that account for the computational properties of the thalamic burst code. Thus, our results suggest the n-spike burst code is a general property of thalamic neurons.

  5. Burst and Persistent Emission Properties during the Recent Active Episode of the Anomalous X-Ray Pulsar 1E 1841-045

    Science.gov (United States)

    Lin, Lin; Kouveliotou, Chryssa; Gogus, Ersin; van der Horst, Alexander J.; Watts, Anna L.; Baring, Matthew G.; Kaneko, Yuki; Wijers, Ralph A. M. J.; Woods, Peter M.; Barthelmy, Scott; Burgess, J. Michael; Chaplin, Vandiver; Gehrels, Neil; Goldstein, Adam; Granot, Jonathan; Guiriec, Sylvain; Mcenery, Julie; Preece, Robert D.; Tierney, David; van der Klis, Michiel; von Kienlin, Andreas; Zhang, Shuang Nan

    2011-01-01

    SWift/BAT detected the first burst from 1E 1841-045 in May 2010 with intermittent burst activity recorded through at least July 2011. Here we present Swift and Fermi/GBM observations of this burst activity and search for correlated changes to the persistent X-ray emission of the source. The T90 durations of the bursts range between 18 - 140 ms, comparable to other magnetar burst durations, while the energy released in each burst ranges between (0.8-25) x 1038 erg, which is in the low side of SGR bursts. We find that the bursting activity did not have a significant effect on the persistent flux level of the source. We argue that the mechanism leading to this sporadic burst activity in IE 1841-045 might not involve large scale restructuring (either crustal or magnetospheric) as seen in other magnetar sources.

  6. Burst and Persistent Emission Properties during the Recent Active Episode of the Anomalous X-ray Pulsar 1E 1841-045

    CERN Document Server

    Lin, Lin; Gogus, Ersin; van der Horst, Alexander J; Watts, Anna L; Baring, Matthew G; Kaneko, Yuki; Wijers, Ralph A M J; Woods, Peter M; Barthelmy, Scott; Burgess, J Michael; Chaplin, Vandiver; Gehrels, Neil; Goldstein, Adam; Granot, Jonathan; Guiriec, Sylvain; Mcenery, Julie; Preece, Robert D; Tierney, David; van der Klis, Michiel; von Kienlin, Andreas; Zhang, Shuang Nan

    2011-01-01

    Swift/BAT detected the first burst from 1E 1841-045 in May 2010 with intermittent burst activity recorded through at least July 2011. Here we present Swift and Fermi/GBM observations of this burst activity and search for correlated changes to the persistent X-ray emission of the source. The T90 durations of the bursts range between 18-140 ms, comparable to other magnetar burst durations, while the energy released in each burst ranges between (0.8 - 25)E38 erg, which is in the low side of SGR bursts. We find that the bursting activity did not have a significant effect on the persistent flux level of the source. We argue that the mechanism leading to this sporadic burst activity in 1E 1841-045 might not involve large scale restructuring (either crustal or magnetospheric) as seen in other magnetar sources.

  7. Exceptionally strong easterly wind burst stalling El Niño of 2014.

    Science.gov (United States)

    Hu, Shineng; Fedorov, Alexey V

    2016-02-23

    Intraseasonal wind bursts in the tropical Pacific are believed to affect the evolution and diversity of El Niño events. In particular, the occurrence of two strong westerly wind bursts (WWBs) in early 2014 apparently pushed the ocean-atmosphere system toward a moderate to strong El Niño--potentially an extreme event according to some climate models. However, the event's progression quickly stalled, and the warming remained very weak throughout the year. Here, we find that the occurrence of an unusually strong basin-wide easterly wind burst (EWB) in June was a key factor that impeded the El Niño development. It was shortly after this EWB that all major Niño indices fell rapidly to near-normal values; a modest growth resumed only later in the year. The easterly burst and the weakness of subsequent WWBs resulted in the persistence of two separate warming centers in the central and eastern equatorial Pacific, suppressing the positive Bjerknes feedback critical for El Niño. Experiments with a climate model with superimposed wind bursts support these conclusions, pointing to inherent limits in El Niño predictability. Furthermore, we show that the spatial structure of the easterly burst matches that of the observed decadal trend in wind stress in the tropical Pacific, suggesting potential links between intraseasonal wind bursts and decadal climate variations.

  8. FERMIGBRST - Fermi GBM Burst Catalog

    Data.gov (United States)

    National Aeronautics and Space Administration — This table lists all of the triggers observed by a subset of the 14 GBM detectors (12 NaI and 2 BGO) which have been classified as gamma-ray bursts (GRBs). Note that...

  9. Millisecond extragalactic radio bursts as magnetar flares

    CERN Document Server

    Popov, S B

    2013-01-01

    Properties of the population of millisecond extragalactic radio bursts discovered by Thornton et al. (2013) are in good correspondence with the hypothesis that such events are related to hyperflares of magnetars, as was proposed by us after the first observation of an extragalactic millisecond radio burst by Lorimer et al. (2007). We also point that some of multiple millisecond radio bursts from M31 discovered by Rubio-Herrera et al. (2013) also can be related to weaker magnetar bursts.

  10. Posttranslationally caused bioluminescence burst of the Escherichia coli luciferase reporter strain.

    Science.gov (United States)

    Ideguchi, Yamato; Oshikoshi, Yuta; Ryo, Masashi; Motoki, Shogo; Kuwano, Takashi; Tezuka, Takafumi; Aoki, Setsuyuki

    2016-01-01

    We continuously monitored bioluminescence from a wild-type reporter strain of Escherichia coli (lacp::luc+/WT), which carries the promoter of the lac operon (lacp) fused with the firefly luciferase gene (luc+). This strain showed a bioluminescence burst when shifted into the stationary growth phase. Bioluminescence profiles of other wild-type reporter strains (rpsPp::luc+ and argAp::luc+) and gene-deletion reporter strains (lacp::luc+/crp- and lacp::luc+/lacI-) indicate that transcriptional regulation is not responsible for generation of the burst. Consistently, changes in the luciferase protein levels did not recapitulate the profile of the burst. On the other hand, dissolved oxygen levels increased over the period across the burst, suggesting that the burst is, at least partially, caused by an increase in intracellular oxygen levels. We discuss limits of the firefly luciferase when used as a reporter for gene expression and its potential utility for monitoring metabolic changes in cells.

  11. GRANAT/WATCH catalogue of cosmic gamma-ray bursts: December 1989 to September 1994

    DEFF Research Database (Denmark)

    Sazonov, S.Y.; Sunyaev, R.A.; Terekhov, O.V.;

    1998-01-01

    V. We have determined the celestial positions of the sources of 47 bursts. Their localization regions (at 3 sigma confidence level) are equivalent in area to circles with radii ranging from 0.2 to 1.6 deg. The burst sources appear isotropically distributed on the sky on large angular scales....

  12. Long-term relationships between cholinergic tone, synchronous bursting and synaptic remodeling.

    Directory of Open Access Journals (Sweden)

    Maya Kaufman

    Full Text Available Cholinergic neuromodulation plays key roles in the regulation of neuronal excitability, network activity, arousal, and behavior. On longer time scales, cholinergic systems play essential roles in cortical development, maturation, and plasticity. Presumably, these processes are associated with substantial synaptic remodeling, yet to date, long-term relationships between cholinergic tone and synaptic remodeling remain largely unknown. Here we used automated microscopy combined with multielectrode array recordings to study long-term relationships between cholinergic tone, excitatory synapse remodeling, and network activity characteristics in networks of cortical neurons grown on multielectrode array substrates. Experimental elevations of cholinergic tone led to the abrupt suppression of episodic synchronous bursting activity (but not of general activity, followed by a gradual growth of excitatory synapses over hours. Subsequent blockage of cholinergic receptors led to an immediate restoration of synchronous bursting and the gradual reversal of synaptic growth. Neither synaptic growth nor downsizing was governed by multiplicative scaling rules. Instead, these occurred in a subset of synapses, irrespective of initial synaptic size. Synaptic growth seemed to depend on intrinsic network activity, but not on the degree to which bursting was suppressed. Intriguingly, sustained elevations of cholinergic tone were associated with a gradual recovery of synchronous bursting but not with a reversal of synaptic growth. These findings show that cholinergic tone can strongly affect synaptic remodeling and synchronous bursting activity, but do not support a strict coupling between the two. Finally, the reemergence of synchronous bursting in the presence of elevated cholinergic tone indicates that the capacity of cholinergic neuromodulation to indefinitely suppress synchronous bursting might be inherently limited.

  13. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    DEFF Research Database (Denmark)

    Hansen, Henrik H; Jensen, Majbrit M; Overgaard, Agnete

    2013-01-01

    Tesofensine is a triple monoamine reuptake inhibitor which inhibits noradrenaline, 5-HT and dopamine reuptake. Tesofensine is currently in clinical development for the treatment of obesity, however, the pharmacological basis for its strong and sustained effects in obesity management is not clarif......, tesofensine produces weight loss together with reversal of lowered forebrain dopamine levels in DIO rats, suggesting that tesofensine's anti-obesity effects, at least in part, are associated with positive modulation of central dopaminergic activity....... is not clarified. Tesofensine effectively induces appetite suppression in the diet-induced obese (DIO) rat partially being ascribed to an indirect stimulation of central dopamine receptor function subsequent to blocked dopamine transporter activity. This is interesting, as obese patients have reduced central...... dopaminergic activity thought to provide a drive for compensatory overeating, but whether treatment with an uptake inhibitor counteracts these changes or not has not been investigated. Tesofensine treatment (2.0mg/kg/day for 14days) caused a pronounced anorexigenic and weight-reducing response in DIO rats...

  14. Quarkonium suppression

    Indian Academy of Sciences (India)

    P Petreczky

    2003-04-01

    I discuss quarkonium suppression in equilibrated strongly interacting matter. After a brief review of basic features of quarkonium production I discuss the application of recent lattice data on the heavy quark potential to the problem of quarkonium dissociation as well as the problem of direct lattice determination of quarkonium properties in finite temperature lattice QCD.

  15. Superposition of Individual Activities: Urea-Mediated Suppression of Nitrate Uptake in the Dinoflagellate Prorocentrum minimum Revealed at the Population and Single-Cell Levels

    Science.gov (United States)

    Matantseva, Olga; Skarlato, Sergei; Vogts, Angela; Pozdnyakov, Ilya; Liskow, Iris; Schubert, Hendrik; Voss, Maren

    2016-01-01

    Dinoflagellates readily use diverse inorganic and organic compounds as nitrogen sources, which is advantageous in eutrophied coastal areas exposed to high loads of anthropogenic nutrients, e.g., urea, one of the most abundant organic nitrogen substrates in seawater. Cell-to-cell variability in nutritional physiology can further enhance the diversity of metabolic strategies among dinoflagellates of the same species, but it has not been studied in free-living microalgae. We applied stable isotope tracers, isotope ratio mass spectrometry and nanoscale secondary ion mass spectrometry (NanoSIMS) to investigate the response of cultured nitrate-acclimated dinoflagellates Prorocentrum minimum to a sudden input of urea and the effect of urea on the concurrent nitrate uptake at the population and single-cell levels. We demonstrate that inputs of urea lead to suppression of nitrate uptake by P. minimum, and urea uptake exceeds the concurrent uptake of nitrate. Individual dinoflagellate cells within a population display significant heterogeneity in the rates of nutrient uptake and extent of the urea-mediated inhibition of the nitrate uptake, thus forming several groups characterized by different modes of nutrition. We conclude that urea originating from sporadic sources is rapidly utilized by dinoflagellates and can be used in biosynthesis or stored intracellularly depending on the nutrient status; therefore, sudden urea inputs can represent one of the factors triggering or supporting harmful algal blooms. Significant physiological heterogeneity revealed at the single-cell level is likely to play a role in alleviation of intra-population competition for resources and can affect the dynamics of phytoplankton populations and their maintenance in natural environments. PMID:27610101

  16. Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.

    Science.gov (United States)

    Lee, Joomin; Hahm, Eun-Ryeong; Marcus, Adam I; Singh, Shivendra V

    2015-06-01

    We have shown previously that withaferin A (WA), a bioactive component of the medicinal plant Withania somnifera, inhibits growth of cultured and xenografted human breast cancer cells and prevents breast cancer development and pulmonary metastasis incidence in a transgenic mouse model. The present study was undertaken to determine if the anticancer effect of WA involved inhibition of epithelial-mesenchymal transition (EMT). Experimental EMT induced by exposure of MCF-10A cells to tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β) was partially reversed by treatment with WA but not by its structural analogs withanone or withanolide A. Combined TNF-α and TGF-β treatments conferred partial protection against MCF-10A cell migration inhibition by WA. Inhibition of TNF-α and TGF-β-induced MCF-10A cell migration by WA exposure was modestly attenuated by knockdown of E-cadherin protein. MCF-7 and MDA-MB-231 cells exposed to WA exhibited sustained (MCF-7) or transient (MDA-MB-231) induction of E-cadherin protein. On the other hand, the level of vimentin protein was increased markedly after 24 h treatment of MDA-MB-231 cells with WA. WA-induced apoptosis was not affected by vimentin protein knockdown in MDA-MB-231 cells. Protein level of vimentin was significantly lower in the MDA-MB-231 xenografts as well as in MMTV-neu tumors from WA-treated mice compared with controls. The major conclusions of the present study are that (a) WA treatment inhibits experimental EMT in MCF-10A cells, and (b) mammary cancer growth inhibition by WA administration is associated with suppression of vimentin protein expression in vivo.

  17. First upper limits from LIGO on gravitational wave bursts

    Energy Technology Data Exchange (ETDEWEB)

    B. Abbott et al.

    2004-03-09

    We report on a search for gravitational wave bursts using data from the first science run of the LIGO detectors. Our search focuses on bursts with durations ranging from 4 ms to 100 ms, and with significant power in the LIGO sensitivity band of 150 to 3000 Hz. We bound the rate for such detected bursts at less than 1.6 events per day at 90% confidence level. This result is interpreted in terms of the detection efficiency for ad hoc waveforms (Gaussians and sine-Gaussians) as a function of their root-sum-square strain h{sub rss}; typical sensitivities lie in the range h{sub rss} {approx} 10{sup -19} - 10{sup -17} strain/{radical}Hz, depending on waveform. We discuss improvements in the search method that will be applied to future science data from LIGO and other gravitational wave detectors.

  18. First upper limits from LIGO on gravitational wave bursts

    CERN Document Server

    Abbott, B; Adhikari, R; Ageev, A N; Allen, B; Amin, R; Anderson, S B; Anderson, W G; Araya, M; Armandula, H; Asiri, F; Aufmuth, P; Aulbert, C; Babak, S V; Balasubramanian, R; Ballmer, S; Barish, B C; Barker, D; Barker-Patton, C; Barnes, M; Barr, B; Barton, M A; Bayer, K; Beausoleil, R; Belczynski, K; Bennett, R; Berukoff,S J; Betzwieser, J; Bhawal, B; Bilenko, I A; Billingsley, G; Black, E; Blackburn, K; Bland-Weaver, B; Bochner, B; Bogue, L; Bork, R G; Bose, S; Brady, P R; Braginsky, V B; Brau, J E; Brown, D A; Brozek, S; Bullington, A; Buonanno, A; Burgess, R; Busby, D; Butler, W E; Byer, R L; Cadonati, L; Cagnoli, G; Camp, J B; Cantley, C A; Cardenas, L; Carter, K; Casey, M M; Castiglione, J; Chandler, A; Chapsky, J; Charlton, P; Chatterji, S; Chen, Y; Chickarmane, V; Chin, D; Christensen, N; Churches, D; Colacino, C N; Coldwell, R; Coles, M; Cook, D; Corbitt, T; Coyne, D; Creighton, J D E; Creighton, T D; Crooks, D R M; Csatorday, P; Cusack, B J; Cutler, C; D'Ambrosio, E; Danzmann, K; Davies, R; Daw, E; De Bra, D; Delker, T; DeSalvo, R; Dhurandhar, S V; Ding, H; Drever, R W P; Dupuis, R J; Ebeling, C; Edlund, J; Ehrens, P; Elliffe, E J; Etzel, T; Evans, M; Evans, T; Fallnich, C; Farnham, D; Fejer, M M; Fine, M; Finn, L S; Flanagan, E; Freise, A; Frey, R; Fritschel, P; Frolov, V; Fyffe, M; Ganezer, K S; Giaime, J A; Gillespie, A; Goda, K; González, G; Goler, S; Grandclément, P; Grant, A; Gray, C; Gretarsson, A M; Grimmett, D; Grote, H; Grünewald, S; Günther, M; Gustafson, E; Gustafson, R; Hamilton, W O; Hammond, M; Hanson, J; Hardham, C; Harry, G; Hartunian, A; Heefner, J; Hefetz, Y; Heinzel, G; Heng, I S; Hennessy, M; Hepler, N; Heptonstall, A; Heurs, M; Hewitson, M; Hindman, N; Hoang, P; Hough, J; Hrynevych, M; Hua, W; Ingley, R; Ito, M; Itoh, Y; Ivanov, A; Jennrich, O; Johnson, W W; Johnston, W; Jones, L; Jungwirth, D; Kalogera, V; Katsavounidis, E; Kawabe, K; Kawamura, S; Kells, W; Kern, J; Khan, A; Killbourn, S; Killow, C J; Kim, C; King, C; King, P; Klimenko, S; Kloevekorn, P; Koranda, S; Kotter, K; Kovalik, Yu; Kozak, D; Krishnan, B; Landry, M; Langdale, J; Lantz, B; Lawrence, R; Lazzarini, A; Lei, M; Leonhardt, V; Leonor, I; Libbrecht, K; Lindquist, P; Liu, S; Logan, J; Lormand, M; Lubinski, M; Lück, H B; Lyons, T T; Machenschalk, B; MacInnis, M; Mageswaran, M; Mailand, K; Majid, W; Malec, M; Mann, F; Marin, A; Marka, S; Maros, E; Mason, J; Mason, K O; Matherny, O; Matone, L; Mavalvala, N; McCarthy, R; McClelland, D E; McHugh, M; McNamara, P; Mendell, G; Meshkov, S; Messenger, C; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Miyakawa, O; Miyoki, S; Mohanty, S; Moreno, G; Mossavi, K; Mours, B; Müller, G; Mukherjee, S; Myers, J; Nagano, S; Nash, T; Naundorf, H; Nayak, R; Newton, G; Nocera, F; Nutzman, P; Olson, T; O'Reilly, B; Ottaway, D J; Ottewill, A; Ouimette, D A; Overmier, H; Owen, B J; Papa, M A; Parameswariah, C; Parameshwaraiah, V; Pedraza, M; Penn, S; Pitkin, M; Plissi, M; Pratt, M; Quetschke, V; Raab, F; Radkins, H; Rahkola, R; Rakhmanov, M; Rao, S R; Redding, D; Regehr, M W; Regimbau, T; Reilly, K T; Reithmaier, K; Reitze, D H; Richman, S; Riesen, R; Riles, K; Rizzi, A; Robertson, D I; Robertson, N A; Robison, L; Roddy, S; Rollins, J; Romano, J D; Romie, J; Rong, H; Rose, D; Rotthoff, E; Rowan, S; Rüdiger, A; Russell, P; Ryan, K; Salzman, I; Sanders, G H; Sannibale, V; Sathyaprakash, B; Saulson, P R; Savage, R; Sazonov, A; Schilling, R; Schlaufman, K; Schmidt, V; Schofield, R; Schrempel, M; Schutz, B F; Schwinberg, P; Scott, S M; Searle, A C; Sears, B; Seel, S; Sengupta, A S; Shapiro, C A; Shawhan, P S; Shoemaker, D H; Shu, Q Z; Sibley, A; Siemens, X; Sievers, L; Sigg, D; Sintes, A M; Skeldon, K D; Smith, J R; Smith, M; Smith, M R; Sneddon, P; Spero, R; Stapfer, G; Strain, K A; Strom, D; Stuver, A; Summerscales, T; Sumner, M C; Sutton, P J; Sylvestre, J; Takamori, A; Tanner, D B; Tariq, H; Taylor, I; Taylor, R; Thorne, K S; Tibbits, M; Tilav, S; Tinto, M; Tokmakov, K V; Torres, C; Torrie, C; Traeger, S; Traylor, G; Tyler, W; Ugolini, D W; Vallisneri, M; Van, M; Putten; Vass, S; Vecchio, A; Vorvick, C; Vyachanin, S P; Wallace, L; Walther, H; Ward, H; Ware, B; Watts, K; Webber, D; Weidner, A; Weiland, U; Weinstein, A; Weiss, R; Welling, H; Wen, L; Wen, S; Whelan, J T; Whitcomb, S E; Whiting, B F; Willems, P A; Williams, P R; Williams, R; Willke, B; Wilson, A; Winjum, B J; Winkler, W; Wise, S; Wiseman, A G; Woan, G; Wooley, R; Worden, J; Yakushin, I; Yamamoto, H; Yoshida, S; Zawischa, I; Zhang, L; Zotov, N P; Zucker, M; Zweizig, J

    2004-01-01

    We report on a search for gravitational wave bursts using data from the first science run of the LIGO detectors. Our search focuses on bursts with durations ranging from 4 ms to 100 ms, and with significant power in the LIGO sensitivity band of 150 to 3000 Hz. We bound the rate for such detected bursts at less than 1.6 events per day at 90% confidence level. This result is interpreted in terms of the detection efficiency for ad hoc waveforms (Gaussians and sine-Gaussians) as a function of their root-sum-square strain h_{rss}; typical sensitivities lie in the range h_{rss} ~ 10^{-19} - 10^{-17} strain/rtHz, depending on waveform. We discuss improvements in the search method that will be applied to future science data from LIGO and other gravitational wave detectors.

  19. A congestion alleviated scheme in optical burst switching network

    Institute of Scientific and Technical Information of China (English)

    Gang Wang; Hongxiang Wang; Yuefeng Ji

    2008-01-01

    An optical burst switching (OBS) network platform is established with a ring topology of three nodes. A congestion alleviated scheme using advanced token protocol and wavelength tunable receivers is demonstrated to optimize the network platform. Experimental results testify that this scheme can resist collision at the level of 0.1% congestion rate.

  20. Spindle Bursts in Neonatal Rat Cerebral Cortex

    Directory of Open Access Journals (Sweden)

    Jenq-Wei Yang

    2016-01-01

    Full Text Available Spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex neocortical-subcortical circuits involving in many cases the participation of motor brain regions. Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i the functional properties of spindle bursts, (ii the mechanisms underlying their generation, (iii the synchronous patterns and cortical networks associated with spindle bursts, and (iv the physiological and pathophysiological role of spindle bursts during early cortical development.

  1. Spindle Bursts in Neonatal Rat Cerebral Cortex.

    Science.gov (United States)

    Yang, Jenq-Wei; Reyes-Puerta, Vicente; Kilb, Werner; Luhmann, Heiko J

    2016-01-01

    Spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex neocortical-subcortical circuits involving in many cases the participation of motor brain regions. Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.

  2. Gamma Ray Bursts Cook Book I: Formulation

    CERN Document Server

    Ziaeepour, Houri

    2008-01-01

    Since the suggestion of relativistic shocks as the origin of gamma-ray bursts (GRBs) in early 90's, the mathematical formulation of this process has stayed at phenomenological level. One of the reasons for the slow development of theoretical works in this domain has been the simple power-law behaviour of the afterglows hours or days after the prompt gamma-ray emission. Nowadays with the launch of the Swift satellite, gamma-ray bursts can be observed in multi-wavelength from a few tens of seconds after trigger onward. These observations have leaded to the discovery of features unexplainable by the simple formulation of the shocks and emission processes used up to now. But "devil is in details" and some of these features may be explained with a more detailed formulation of phenomena and without adhoc addition of new processes. Such a formulation is the goal of this work. We present a consistent formulation of the collision between two spherical relativistic shells. The model can be applied to both internal and ...

  3. Assessing the reliability of eBURST using simulated populations with known ancestry

    Directory of Open Access Journals (Sweden)

    Connor Thomas R

    2007-04-01

    Full Text Available Abstract Background The program eBURST uses multilocus sequence typing data to divide bacterial populations into groups of closely related strains (clonal complexes, predicts the founding genotype of each group, and displays the patterns of recent evolutionary descent of all other strains in the group from the founder. The reliability of eBURST was evaluated using populations simulated with different levels of recombination in which the ancestry of all strains was known. Results For strictly clonal simulations, where all allelic change is due to point mutation, the groups of related strains identified by eBURST were very similar to those expected from the true ancestry and most of the true ancestor-descendant relationships (90–98% were identified by eBURST. Populations simulated with low or moderate levels of recombination showed similarly high performance but the reliability of eBURST declined with increasing recombination to mutation ratio. Populations simulated under a high recombination to mutation ratio were dominated by a single large straggly eBURST group, which resulted from the incorrect linking of unrelated groups of strains into the same eBURST group. The reliability of the ancestor-descendant links in eBURST diagrams was related to the proportion of strains in the largest eBURST group, which provides a useful guide to when eBURST is likely to be unreliable. Conclusion Examination of eBURST groups within populations of a range of bacterial species showed that most were within the range in which eBURST is reliable, and only a small number (e.g. Burkholderia pseudomallei and Enterococcus faecium appeared to have such high rates of recombination that eBURST is likely to be unreliable. The study also demonstrates how three simple tests in eBURST v3 can be used to detect unreliable eBURST performance and recognise populations in which there appears to be a high rate of recombination relative to mutation.

  4. Higher Levels of Osteoprotegerin and Immune Activation/Immunosenescence Markers Are Correlated with Concomitant Bone and Endovascular Damage in HIV-Suppressed Patients.

    Directory of Open Access Journals (Sweden)

    Alessandra D'Abramo

    Full Text Available HIV-infected patients appear to have a significantly greater risk of non-AIDS comorbidities such as osteoporosis and atherosclerosis. Subjects with osteoporosis are at a higher risk of developing cardiovascular disease than those with normal bone mass, therefore a possible relation between these two conditions can be hypothesized. In the setting of HIV infection, several factors might contribute to bone disease and endothelial dysfunction. The aim of our study was to evaluate the relationship between bone and cardiovascular disease and to investigate the role of traditional factors, T-cell phenotype and osteoprotegerin in HIV positive subjects on effective antiretroviral therapy. We included 94 HIV positive subjects on antiretroviral therapy with virological suppression and 41 healthy subjects matched for age and gender as a control group. Carotid-Intima Media Thickness (c-IMT and bone mineral density (BMD were performed by ultrasound and DEXA, respectively. CD4+/CD8+ T-cell activation, senescence and osteoprotegerin plasma levels were measured by flow-cytometry and ELISA, respectively. Among HIV positive patients, 56.4% had osteopenia/osteoporosis and 45.7% had pathological c-IMT (>0.9 mm. Subjects with pathological c-IMT and BMD exhibited higher CD4+ and CD8+ activated, CD8+ senescent and osteoprotegerin than subjects with normal c-IMT and BMD. HIV positive subjects with osteopenia/osteoporosis had higher c-IMT than subjects with normal BMD, and linear regression analysis showed a negative correlation between BMD and c-IMT. Several factors are implicated in the pathogenesis of non-AIDS comorbidities in HIV positive patients. Osteoprotegerin together with inflammation and immunosenescence in HIV positive patients could affect bone and vascular system and could be considered as a possible common link between these two diseases.

  5. X-Ray Reflection and an Exceptionally Long Thermonuclear Helium Burst from IGR J17062-6143

    Science.gov (United States)

    Keek, L.; Iwakiri, W.; Serino, M.; Ballantyne, D. R.; in’t Zand, J. J. M.; Strohmayer, T. E.

    2017-02-01

    Thermonuclear X-ray bursts from accreting neutron stars power brief but strong irradiation of their surroundings, providing a unique way to study accretion physics. We analyze MAXI/Gas Slit Camera and Swift/XRT spectra of a day-long flash observed from IGR J17062-6143 in 2015. It is a rare case of recurring bursts at a low accretion luminosity of 0.15% Eddington. Spectra from MAXI, Chandra, and NuSTAR observations taken between the 2015 burst and the previous one in 2012 are used to determine the accretion column. We find it to be consistent with the burst ignition column of 5 × 1010 g cm‑2, which indicates that it is likely powered by burning in a deep helium layer. The burst flux is observed for over a day, and decays as a straight power law: F ∝ t ‑1.15. The burst and persistent spectra are well described by thermal emission from the neutron star, Comptonization of this emission in a hot optically thin medium surrounding the star, and reflection off the photoionized accretion disk. At the burst peak, the Comptonized component disappears, when the burst may dissipate the Comptonizing gas, and it returns in the burst tail. The reflection signal suggests that the inner disk is truncated at ∼102 gravitational radii before the burst, but may move closer to the star during the burst. At the end of the burst, the flux drops below the burst cooling trend for 2 days, before returning to the pre-burst level.

  6. Self-organized dendritic sidebranching in directional solidification: sidebranch coherence within uncorrelated bursts.

    Science.gov (United States)

    Pocheau, Alain; Bodea, Simona; Georgelin, Marc

    2009-09-01

    We experimentally study the level of organization of dendritic sidebranching in directional solidification. For this, we extract successive interface positions at a fixed distance from the dendrite tips and we perform various correlation analyses. The sidebranching signals appear composed of randomly distributed bursts in which sidebranching coherence is surprisingly large and robust. This is attested by the large autocorrelation found in single bursts and the large cross-correlation found in any couple of bursts, even belonging to different sides of a dendrite or to different dendrites. However, the phase coherence of sidebranching breaks down at the transition between bursts. This restricts the coherence of extended sidebranching signals to a mean burst length and prevents the occurrence of large scale cross-correlation between them. This balanced view on sidebranching coherence stresses the capability of self-organization of dendrites in material science and sheds light on the nature of sidebranching on curved growing forms.

  7. Performance evaluation of a burst-mode EDFA in an optical packet and circuit integrated network.

    Science.gov (United States)

    Shiraiwa, Masaki; Awaji, Yoshinari; Furukawa, Hideaki; Shinada, Satoshi; Puttnam, Benjamin J; Wada, Naoya

    2013-12-30

    We experimentally investigate the performance of burst-mode EDFA in an optical packet and circuit integrated system. In such networks, packets and light paths can be dynamically assigned to the same fibers, resulting in gain transients in EDFAs throughout the network that can limit network performance. Here, we compare the performance of a 'burst-mode' EDFA (BM-EDFA), employing transient suppression techniques and optical feedback, with conventional EDFAs, and those using automatic gain control and previous BM-EDFA implementations. We first measure gain transients and other impairments in a simplified set-up before making frame error-rate measurements in a network demonstration.

  8. Constraining the Solar Coronal Magnetic Field Strength using Split-band Type II Radio Burst Observations

    Science.gov (United States)

    Kishore, P.; Ramesh, R.; Hariharan, K.; Kathiravan, C.; Gopalswamy, N.

    2016-11-01

    We report on low-frequency radio (85-35 MHz) spectral observations of four different type II radio bursts, which exhibited fundamental-harmonic emission and split-band structure. Each of the bursts was found to be closely associated with a whitelight coronal mass ejection (CME) close to the Sun. We estimated the coronal magnetic field strength from the split-band characteristics of the bursts, by assuming a model for the coronal electron density distribution. The choice of the model was constrained, based on the following criteria: (1) when the radio burst is observed simultaneously in the upper and lower bands of the fundamental component, the location of the plasma level corresponding to the frequency of the burst in the lower band should be consistent with the deprojected location of the leading edge (LE) of the associated CME; (2) the drift speed of the type II bursts derived from such a model should agree closely with the deprojected speed of the LE of the corresponding CMEs. With the above conditions, we find that: (1) the estimated field strengths are unique to each type II burst, and (2) the radial variation of the field strength in the different events indicate a pattern. It is steepest for the case where the heliocentric distance range over which the associated burst is observed is closest to the Sun, and vice versa.

  9. Hardness/intensity correlations among BATSE bursts

    Science.gov (United States)

    Paciesas, William S.; Pendleton, Geoffrey N.; Kouveliotou, Chryssa; Fishman, Gerald J.; Meegan, Charles A.; Wilson, Robert B.

    1992-01-01

    Conclusions about the nature of gamma-ray bursts derived from the size-frequency distribution may be altered if a significant correlation exists between burst intensity and spectral shape. Moreover, if gamma-ray bursts have a cosmological origin, such a correlation may be expected to result from the expansion of the universe. We have performed a rudimentary search of the BATSE bursts for hardness/intensity correlations. The range of spectral shapes was determined for each burst by computing the ratio of the intensity in the range 100-300 keV to that in 55-300 keV. We find weak evidence for the existence of a correlation, the strongest effect being present when comparing the maximum hardness ratio for each burst with its maximum rate.

  10. Stirling Colgate and Gamma-Ray Bursts

    Science.gov (United States)

    Lamb, Donald

    2014-10-01

    Even before the discovery of gamma-ray bursts (GRBs), Stirling Colgate proposed that bursts of x rays and gamma rays might be produced by a relativistic shock created in the supernova explosion of a massive star. We trace the scientific story of GRBs from their detection to the present, highlighting along the way Stirling's interest in them and his efforts to understand them. We summarize our current understanding that short, soft, repeating bursts are produced by magnetic neutron stars; short, hard bursts are produced by the mergers of neutron star-neutron star binaries; and long, hard bursts are produced by the core collapse of massive stars that have lost their hydrogen and helium envelopes. We then discuss some important open questions about GRBs and how they might be answered. We conclude by describing the recent serendipitous discovery of an x-ray burst of exactly the kind he proposed, and the insights into core collapse supernovae and GRBs that it provided.

  11. Pulse Phase Dependence of the Magnetar Bursts

    Indian Academy of Sciences (India)

    Chetana Jain; Anjan Dutta; Biswajit Paul

    2007-12-01

    We report here results from a study of X-ray bursts from 3 magnetar candidates (SGR 1806–20, SGR 1900+14 and AXP 1E 2259+586). We have searched for a pulse phase dependence of the X-ray burst rate from these sources. X-ray light curves were obtained with the Proportional Counter Array on-board the Rossi X-ray Timing Explorer during the periods of intense burst activity in these sources. On detailed analysis of the three sources, we found a very significant burst rate for all pulsar phases. However, some locations appear to produce bursts slightly more often, rendering the non-isotropic distribution. Only in the case of SGR 1900+14, there is a clear pulse phase dependence of burst rate.

  12. Physics of gamma-ray bursts

    Science.gov (United States)

    Lamb, D. Q.

    1984-01-01

    Attention is given to the accumulating evidence for the view that gamma-ray bursts come from strongly magnetic neutron stars, discussing the physical properties of the emission region and the radiation processes expected in strong magnetic fields, and emphasizing that the observed burst spectra require that the emission region be optically thin. This entails that the energy of the emitting plasma and/or the plasma itself be continuously replenished during a burst, and that the cooling time scale of the emitting plasma be much shorter than the observed duration of the bursts. This characteristic of the cooling time scale implies that the burst intensity and spectrum can vary on extremely short time scales, and that the burst duration must have a separate explanation. It is emphasized that synchrotron emission is favored as the gamma-ray production mechanism; it is the only mechanism capable of satisfying the optical thinness constraint while producing the observed luminosity.

  13. Statistics of gamma ray burst temporal asymmetry

    CERN Document Server

    Link, B; Link, Bennett; Epstein, Richard

    1996-01-01

    We study the temporal asymmetry of over 600 bursts from the BATSE 3B catalog, encompassing a 200-fold range in peak flux. By comparing the rates of rise and fall of the flux near the highest burst peak, we find that about two-thirds of the bursts exhibit a preferred asymmetry in the sense that the flux rises more rapidly than it falls, confirming the conclusions of previous studies employing smaller databases. The statistical significance of the average time asymmetry of the sample is >99.999\\%; therefore, models that predict time symmetry of the burst profile are ruled out. We find no statistically significant correlation between burst temporal asymmetry and peak. This result is consistent with both cosmological and local interpretations of the gamma ray burst phenomenon.

  14. Role of persistent sodium current in bursting activity of mouse neocortical networks in vitro.

    Science.gov (United States)

    van Drongelen, Wim; Koch, Henner; Elsen, Frank P; Lee, Hyong C; Mrejeru, Ana; Doren, Erin; Marcuccilli, Charles J; Hereld, Mark; Stevens, Rick L; Ramirez, Jan-Marino

    2006-11-01

    Most types of electrographic epileptiform activity can be characterized by isolated or repetitive bursts in brain electrical activity. This observation is our motivation to determine mechanisms that underlie bursting behavior of neuronal networks. Here we show that the persistent sodium (Na(P)) current in mouse neocortical slices is associated with cellular bursting and our data suggest that these cells are capable of driving networks into a bursting state. This conclusion is supported by the following observations. 1) Both low concentrations of tetrodotoxin (TTX) and riluzole reduce and eventually stop network bursting while they simultaneously abolish intrinsic bursting properties and sensitivity levels to electrical stimulation in individual intrinsically bursting cells. 2) The sensitivity levels of regular spiking neurons are not significantly affected by riluzole or TTX at the termination of network bursting. 3) Propagation of cellular bursting in a neuronal network depended on excitatory connectivity and disappeared on bath application of CNQX (20 microM) + CPP (10 microM). 4) Voltage-clamp measurements show that riluzole (20 microM) and very low concentrations of TTX (50 nM) attenuate Na(P) currents in the neural membrane within a 1-min interval after bath application of the drug. 5) Recordings of synaptic activity demonstrate that riluzole at this concentration does not affect synaptic properties. 6) Simulations with a neocortical network model including different types of pyramidal cells, inhibitory interneurons, neurons with and without Na(P) currents, and recurrent excitation confirm the essence of our experimental observations that Na(P) conductance can be a critical factor sustaining slow population bursting.

  15. Recent results of zebra patterns in solar radio bursts

    Institute of Scientific and Technical Information of China (English)

    Gennady P.Chernov

    2010-01-01

    This review covers the most recent experimental results and theoretical research on zebra patterns(ZPs)in solar radio bursts.The basic attention is given to events with new peculiar elements of zebra patterns received over the last few years.All new properties are considered in light of both what was known earlier and new theoretical models.Large-scale ZPs consisting of small-scale fiber bursts could be explained by simultaneous inclusion of two mechanisms when whistler waves"highlight"the levels of double plasma resonance(DPR).A unique fine structure was observed in the event on 2006 December 13: spikes in absorption formed dark ZP stripes against the absorptive type Ⅲ-like bursts.The spikes in absorption can appear in accordance with well known mechanisms of absorptive bursts.The additional injection of fast particles filled the loss-cone(breaking the loss-cone distribution),and the generation of the continuum was quenched at these moments.The maximum absorptive effect occurs at the DPR levels.The parameters of millisecond spikes are determined by small dimensions of the particle beams and local scale heights in the radio source.Thus,the DPR model helps to understand several aspects of unusual elements of ZPs.However,the simultaneous existence of several tens of the DPR levels in the corona is impossible for any realistic profile of the plasma density and magnetic field.Three new theories of ZPs are examined.The formation of eigenmodes of transparency and opacity during the propagation of radio waves through regular coronal inhomogeneities is the most natural and promising mechanism.Two other models(nonlinear periodic space-charge waves and scattering of fast protons on ion-sound harmonics)could happen in large radio bursts.

  16. United assembly algorithm for optical burst switching

    Institute of Scientific and Technical Information of China (English)

    Jinhui Yu(于金辉); Yijun Yang(杨教军); Yuehua Chen(陈月华); Ge Fan(范戈)

    2003-01-01

    Optical burst switching (OBS) is a promising optical switching technology. The burst assembly algorithm controls burst assembly, which significantly impacts performance of OBS network. This paper provides a new assembly algorithm, united assembly algorithm, which has more practicability than conventional algorithms. In addition, some factors impacting selections of parameters of this algorithm are discussed and the performance of this algorithm is studied by computer simulation.

  17. Bubble burst as jamming phase transition

    CERN Document Server

    Nishinari, Katsuhiro; Saito, Yukiko Umeno; Watanabe, Tsutomu

    2010-01-01

    Recently research on bubble and its burst attract much interest of researchers in various field such as economics and physics. Economists have been regarding bubble as a disorder in prices. However, this research strategy has overlooked an importance of the volume of transactions. In this paper, we have proposed a bubble burst model by focusing the transactions incorporating a traffic model that represents spontaneous traffic jam. We find that the phenomenon of bubble burst shares many similar properties with traffic jam formation by comparing data taken from US housing market. Our result suggests that the transaction could be a driving force of bursting phenomenon.

  18. Two classes of gamma-ray bursts

    CERN Document Server

    Katz, J I

    1995-01-01

    Data from the 3B Catalogue suggest that short and long GRB are the results of different classes of events, rather than different parameter values within a single class: Short bursts have harder spectra in the BATSE bands, but chiefly long bursts are detected at photon energies over 1 MeV, implying that their hard photons are radiated by a process not found in short bursts. The values of \\langle V/V_{max} \\rangle for short and long bursts differ by 4.3 \\sigma, implying different spatial distributions. Only the soft gamma-ray radiation mechanisms are the same in both classes.

  19. Analysis of historic bursts and burst detection in water supply areas of different size

    NARCIS (Netherlands)

    Bakker, M.; Trietsch, E.A.; Vreeburg, J.H.G.; Rietveld, L.C.

    2014-01-01

    Pipe bursts in water distribution networks lead to water losses and a risk of damaging the urban environment. We studied hydraulic data and customer contact records of 44 real bursts for a better understanding of the phenomena. We found that most bursts were reported to the water company shortly aft

  20. The lipopolysaccharide of Sinorhizobium meliloti suppresses defense-associated gene expression in cell cultures of the host plant Medicago truncatula.

    Science.gov (United States)

    Tellström, Verena; Usadel, Björn; Thimm, Oliver; Stitt, Mark; Küster, Helge; Niehaus, Karsten

    2007-02-01

    In the establishment of symbiosis between Medicago truncatula and the nitrogen-fixing bacterium Sinorhizobium meliloti, the lipopolysaccharide (LPS) of the microsymbiont plays an important role as a signal molecule. It has been shown in cell cultures that the LPS is able to suppress an elicitor-induced oxidative burst. To investigate the effect of S. meliloti LPS on defense-associated gene expression, a microarray experiment was performed. For evaluation of the M. truncatula microarray datasets, the software tool MapMan, which was initially developed for the visualization of Arabidopsis (Arabidopsis thaliana) datasets, was adapted by assigning Medicago genes to the ontology originally created for Arabidopsis. This allowed functional visualization of gene expression of M. truncatula suspension-cultured cells treated with invertase as an elicitor. A gene expression pattern characteristic of a defense response was observed. Concomitant treatment of M. truncatula suspension-cultured cells with invertase and S. meliloti LPS leads to a lower level of induction of defense-associated genes compared to induction rates in cells treated with invertase alone. This suppression of defense-associated transcriptional rearrangement affects genes induced as well as repressed by elicitation and acts on transcripts connected to virtually all kinds of cellular processes. This indicates that LPS of the symbiont not only suppresses fast defense responses as the oxidative burst, but also exerts long-term influences, including transcriptional adjustment to pathogen attack. These data indicate a role for LPS during infection of the plant by its symbiotic partner.

  1. Magnetars and Gamma Ray Bursts

    CERN Document Server

    Bucciantini, N

    2012-01-01

    In the last few years, evidences for a long-lived and sustained engine in Gamma Ray Bursts (GRBs) have increased the attention to the so called millisecond-magnetar model, as a competitive alternative to the standard collapsar scenario. I will review here the key aspects of the {\\it millisecond magnetar} model for Long Duration Gamma Ray Bursts (LGRBs). I will briefly describe what constraints, present observations put on any engine model, both in term of energetic, outflow properties, and the relation with the associated Supernova (SN). For each of these I will show how the millisecond magnetar model satisfies the requirements, what are the limits of the model, how can it be further tested, and what observations might be used to discriminate against it. I will also discuss numerical results that show the importance of the confinement by the progenitor star in explaining the formation of a collimated outflow, how a detailed model for the evolution of the central engine can be built, and show that a wide varie...

  2. Sensitivity of HAWC to Primordial Black Hole Bursts

    CERN Document Server

    Ukwatta, T N; MacGibbon, D Stump J H; Marinelli, S S; Yapici, T; Tollefson, K

    2015-01-01

    Primordial Black Holes (PBHs) are black holes that may have been created in the early Universe and could be as large as supermassive black holes or as small as the Planck scale. It is believed that a black hole has a temperature inversely proportional to its mass and will thermally emit all species of fundamental particles. PBHs with initial masses of 5.0 x 10^14 g should be expiring today with bursts of high-energy gamma radiation in the GeV/TeV energy range. The High Altitude Water Cherenkov (HAWC) observatory is sensitive to the high end of the PBH gamma-ray burst spectrum. Due to its large field of view, duty cycle above 90% and sensitivity up to 100 TeV, the HAWC observatory is well suited to perform a search for PBH bursts. We report that if the PBH explodes within 0.25 light years from Earth and within 26 degrees of zenith, HAWC will have a 95% probability of detecting the PBH burst at the 5 sigma level. Conversely, a null detection from a 2 year or longer HAWC search will set PBH upper limits which ar...

  3. Direct injection, simple and robust analysis of trace-level bromate and bromide in drinking water by IC with suppressed conductivity detection.

    Science.gov (United States)

    Lawal, Wasiu; Gandhi, Jay; Zhang, Chunlong Carl

    2010-08-01

    Bromide is ubiquitously found in drinking water. It is introduced into source water primarily by contact with bromide-containing soils or seawater having high bromide content. Bromide is converted into carcinogenic bromate during ozonation processes employed in some drinking water and wastewater treatment plants. Therefore, monitoring of bromate in drinking water and its precursor bromide in source water is required. The purpose of this study was to survey bromide and bromate concentrations in randomly selected bottle waters of various brands and several tap water samples in the coastal Houston area using a direct-injection ion chromatography (IC) and a suppressed conductivity system. The method employs a simple isocratic IC with loop injection with calculated detection limit of 0.009 microg/L for bromate and 0.028 microg/L for bromide (250-microL sample volume). Allowing the detection of both species at the microg/L level in drinking water, this method does not require specialized instrumentation such as two-dimensional IC, expensive sample preparation, or post-column reactions. The results show that, whereas bromate remains undetected in all five tap water samples, there are significant high concentrations of bromide in the coastal Houston area (294.79 +/- 56.97 microg/L). Its link to potential seawater intrusion need to be further investigated. For bottle water samples randomly collected, 18.2% (2 out of 11) showed detectable amount of both bromide and bromate. The detection of bromate coincides with those bottle water samples that underwent ozonation treatment. Further sample campaign with exclusively ozonated bottle water samples (n = 19) showed 100% detection rate for both bromide and bromate. The 99% confidence intervals were 14.45-37.97 microg/L and 0.32-2.58 microg/L for bromide and bromate, respectively. The highest level of bromate among all ozonated bottle water samples was 7.57 microg/L, a concentration close to the U.S. EPA prescribed limit for

  4. Release from informational masking in children: Effect of multiple signal bursts

    Science.gov (United States)

    Leibold, Lori J.; Bonino, Angela Yarnell

    2009-01-01

    This study examined the degree to which increasing the number of signal presentations provides children with a release from informational masking. Listeners were younger children (5–7 years), older children (8–10 years), and adults. Detection thresholds were measured for a sequence of repeating 50-ms bursts of a 1000-Hz pure-tone signal embedded in a sequence of 10- and 50-ms bursts of a random-frequency, two-tone masker. Masker bursts were played at an overall level of 60-dB sound pressure level in each interval of a two-interval, forced choice adaptive procedure. Performance was examined for conditions with two, four, five, and six signal bursts. Regardless of the number of signal bursts, thresholds for most children were higher than thresholds for most adults. Despite developmental effects in informational masking, however, masked threshold decreased with additional signal bursts by a similar amount for younger children, older children, and adults. The magnitude of masking release for both groups of children and for adults was inconsistent with absolute energy detection. Instead, increasing the number of signal bursts appears to aid children in the perceptual segregation of the fixed-frequency signal from the random-frequency masker as has been previously reported for adults [Kidd, G., et al. (2003). J. Acoust. Soc. Am. 114, 2835–2845]. PMID:19354396

  5. Dark Bursts in the Swift Era: The Palomar 60 inch-Swift Early Optical Afterglow Catalog

    CERN Document Server

    Cenko, S B; Harrison, F A; Fox, D B; Kulkarni, S R; Kasliwal, M M; Ofek, E O; Rau, A; Gal-Yam, A; Frail, D A; Moon, D -S

    2008-01-01

    We present multi-color optical observations of long-duration gamma-ray bursts (GRBs) made over a three year period with the robotic Palomar 60 inch telescope (P60). Our sample consists of all 29 events discovered by Swift for which P60 began observations less than one hour after the burst trigger. We were able to recover 80% of the optical afterglows from this prompt sample, and we attribute this high efficiency to our red coverage. Like Melandri et al. (2008), we find that a significant fraction (~ 50%) of Swift events show a suppression of the optical flux with regards to the X-ray emission (so-called "dark" bursts). Our multi-color photometry demonstrates this is likely due in large part to extinction in the host galaxy. We argue that previous studies, by selecting only the brightest and best-sampled optical afterglows, have significantly underestimated the amount of dust present in typical GRB environments.

  6. Coding Bounds for Multiple Phased-Burst Correction and Single Burst Correction Codes

    CERN Document Server

    Fong, Wai Han

    2011-01-01

    In this paper, two upper bounds on the achievable code rate of linear block codes for multiple phased-burst correction (MPBC) are presented. One bound is constrained to a maximum correctable cyclic burst length within every subblock, or equivalently a constraint on the minimum error free length or gap within every phased-burst. This bound, when reduced to the special case of a bound for single burst correction (SBC), is shown to be the Abramson bound when the cyclic burst length is less than half the block length. The second MPBC bound is developed without the minimum error free gap constraint and is used as a comparison to the first bound.

  7. Photospheric radius expansion during magnetar bursts

    NARCIS (Netherlands)

    A.L. Watts; C. Kouveliotou; A.J. van der Horst; E. Göğüş; Y. Kaneko; M. van der Klis; R.A.M.J. Wijers; A.K. Harding; M.G. Baring

    2010-01-01

    On 2008 August 24 the new magnetar SGR 0501+4516 (discovered by Swift) emitted a bright burst with a pronounced double-peaked structure in hard X-rays, reminiscent of the double-peaked temporal structure seen in some bright thermonuclear bursts on accreting neutron stars. In the latter case this is

  8. Astronomy: Radio burst caught red-handed

    Science.gov (United States)

    Falcke, Heino

    2017-01-01

    For almost a decade, astronomers have observed intense bursts of radio waves from the distant cosmos whose origins were unknown. The source of one such burst has now been identified, but this has only deepened the mystery. See Letter p.58

  9. Using temporal bursts for query modeling

    NARCIS (Netherlands)

    Peetz, M.H.; Meij, E.; de Rijke, M.

    2014-01-01

    We present an approach to query modeling that leverages the temporal distribution of documents in an initially retrieved set of documents. In news-related document collections such distributions tend to exhibit bursts. Here, we define a burst to be a time period where unusually many documents are pu

  10. Biomechanical analysis of short-segment pins Index-level screw fixation for low lumbar burst fractures%Index-level螺钉短节段固定治疗下腰椎爆裂压缩骨折的生物力学研究

    Institute of Scientific and Technical Information of China (English)

    王涛; 马剑雄; 王玉龙; 马信龙; 张晓林; 徐宝山; 杨强

    2013-01-01

    目的 通过对L4椎体爆裂骨折模型以及应用不同方法固定后的生物力学测试,探讨Index-level螺钉短节段固定方法在治疗下腰椎爆裂骨折中的意义.方法 选取10具新鲜尸体腰骶椎标本,通过截骨、切断部分韧带的方法制作L4椎体爆裂骨折模型,然后依序进行长节段固定、短节段固定以及短节段+ Index-level螺钉固定并进行生物力学测试,比较不同固定方法腰椎活动度(range of motion,ROM)的差异.结果 与短节段固定比较,短节段+Index-level螺钉固定在前屈、轴向旋转和侧屈时ROM降低,差异有统计学意义(P<0.05).在后伸位时短节段+Index-level固定稳定性提高,ROM降低32.7%,但差异无统计学意义.结论 Index-level螺钉短节段固定较单纯短节段内固定平均提高32.5%的即刻稳定性,而且比长节段固定保留更大范围ROM.%Objective To establish L4 vertebrae burst fractures and take a biomechanical test of different internal fixations so as to discuss the significance of internal fixation using short-segment plus Index-level screws in treatment of low lumbar burst fractures.Methods Ten fresh human lumbosacral vertebrae specimens were used to establish models of L4 vertebrae burst fractures by corpectomy and partial removal of ligament.Thereafter,the biomechanical test was performed in order as below:longsegment fixation,short-segment fixation and short-segment construction plus Index-level screw fixation.Differences of range of motion (ROM) of the lumbar after three different internal fixations were compared.Results Compared with short-segment fixation,short-segment plus Index-level screw fixation showed that ROM of the lumbar was decreased in front flexion,axial rotation and lateral bending (P < 0.05),but stability was improved and ROM of lumbar was decreased by 32.7% in back extension (P > 0.05).Conclusions Compared with short-segment fixation,the short-segment plus Index-level screw fixation can

  11. FRBCAT: The Fast Radio Burst Catalogue

    Science.gov (United States)

    Petroff, E.; Barr, E. D.; Jameson, A.; Keane, E. F.; Bailes, M.; Kramer, M.; Morello, V.; Tabbara, D.; van Straten, W.

    2016-09-01

    Here, we present a catalogue of known Fast Radio Burst sources in the form of an online catalogue, FRBCAT. The catalogue includes information about the instrumentation used for the observations for each detected burst, the measured quantities from each observation, and model-dependent quantities derived from observed quantities. To aid in consistent comparisons of burst properties such as width and signal-to-noise ratios, we have re-processed all the bursts for which we have access to the raw data, with software which we make available. The originally derived properties are also listed for comparison. The catalogue is hosted online as a Mysql database which can also be downloaded in tabular or plain text format for off-line use. This database will be maintained for use by the community for studies of the Fast Radio Burst population as it grows.

  12. Bright 30 THz Impulsive Solar Bursts

    CERN Document Server

    Kaufmann, P; Marcon, R; Kudaka, A S; Cabezas, D P; Cassiano, M M; Francile, C; Fernandes, L O T; Ramirez, R F Hidalgo; Luoni, M; Marun, A; Pereyra, P; de Souza, R V

    2015-01-01

    Impulsive 30 THz continuum bursts have been recently observed in solar flares, utilizing small telescopes with a unique and relatively simple optical setup concept. The most intense burst was observed together with a GOES X2 class event on October 27, 2014, also detected at two sub-THz frequencies, RHESSI X-rays and SDO/HMI and EUV. It exhibits strikingly good correlation in time and in space with white light flare emission. It is likely that this association may prove to be very common. All three 30 THz events recently observed exhibited intense fluxes in the range of 104 solar flux units, considerably larger than those measured for the same events at microwave and sub-mm wavelengths. The 30 THz burst emission might be part of the same spectral burst component found at sub-THz frequencies. The 30 THz solar bursts open a promising new window for the study of flares at their origin

  13. IMAGING DIAGNOSIS OF THORACOLUMBAR BURST FRACTURES

    Institute of Scientific and Technical Information of China (English)

    Li-yang Dai

    2004-01-01

    Objective To review imaging use in the diagnosis ofthoracolumbar burst fractures and to determine the diagnostic value of different imaging methods.Methods One hundred and fourteen patients with 120 thoracolumbar burst fractures were retrospectively reviewed. Plain radiographs were available in all cases; CT scans and MRI were obtained in 96 and 74 cases, respectively.Results A total of 27 burst fractures were misdiagnosed as other types of fractures on radiographs alone, and accounted for 22.5% of all fractures. The results indicated that plain radiographs often fail to delineate the pathological features of thoracolumbar burst fractures, leading to delay in diagnosis.Conclusion In regard to thoracolumbar injury diagnosis, burst fractures should be differentiated from compression fractures. CT should be routinely indicated and MRI examination, when necessary, may be simultaneously considered.

  14. Epidermal growth factor suppresses insulin-like growth factor binding protein 3 levels in human papillomavirus type 16-immortalized cervical epithelial cells and thereby potentiates the effects of insulin-like growth factor 1.

    Science.gov (United States)

    Hembree, J R; Agarwal, C; Eckert, R L

    1994-06-15

    Human ectocervical epithelial cells are a primary target for infection by oncogenic papillomaviruses, which are strongly implicated as causative agents in the genesis of cervical cancer. Growth factors have been implicated as agents that stimulate proliferation and enhance the possibility of malignant transformation. In the present study we utilize several human papillomavirus (HPV) type 16-immortalized ectocervical epithelial cell lines to investigate the effects of epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) on cell proliferation and the production of IGF binding proteins (IGFBPs). ECE16-1 cells, an HPV16-immortalized/nontumorigenic cell line, maintained in defined medium, produce and release high levels of IGFBP-3 (38/42 kDa) as well as smaller amounts of a 24-kDa IGFBP. Supplementation of defined medium with EGF causes a dose-dependent increase in cell growth and a concomitant decrease in the levels of IGFBP-3 released into the culture medium. EGF suppression of IGFBP-3 is maintained even when EGF-stimulated cell growth is suppressed 67% due to the simultaneous presence of 3 ng/ml of TGF beta 1, indicating that EGF suppression of IGFBP-3 levels is independent of EGF effects on cell growth. EGF suppression of IGFBP-3 production is correlated with a reduction in IGFBP-3 mRNA level. In the presence of EGF, the growth response of the cells to ng amounts of IGF-I is significantly enhanced. Moreover, the simultaneous presence of both EGF and IGF-I reduces the level of IGFBP-3 more efficiently than EGF alone. We also observe that the IGFBP-3 level is decreased and the 24-kDa IGFBP level is increased in HPV16-positive tumorigenic versus nontumorigenic cell lines. This is the first report of EGF acting as a positive regulator of IGF-I action via the IGFBPs. On the basis of these findings, we propose that EGF stimulates ECE16-1 cell growth via a dual-action mechanism by (a) stimulating growth directly via the EGF mitogenic pathway and (b

  15. Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils.

    Science.gov (United States)

    Wang, J P; Raung, S L; Hsu, M F; Chen, C C

    1994-11-01

    1. The possible mechanisms of action of the inhibitory effect of gomisin C on the respiratory burst of rat neutrophils in vitro was investigated. 2. The peptide formyl-Met-Leu-Phe (FMLP) induced superoxide anion (O2-) formation and O2 consumption, which was inhibited by gomisin C in a concentration-dependent manner (IC50 21.5 +/- 4.2 micrograms ml-1 for O2- formation). Gomisin C also suppressed O2- formation and consumption at low concentrations of phorbol myristate acetate (PMA) with an IC50 value of 26.9 +/- 2.1 micrograms ml-1 for O2- formation. However, gomisin C did not affect the responses induced by a high concentration of PMA. 3. Gomisin C had no effect on O2- generation and uric acid formation in the xanthine-xanthine oxidase system, and failed to alter O2- generation during dihydroxyfumaric acid (DHF) autoxidation, indicating that it does not scavenge superoxide. 4. Like trifluoperazine (TFP), gomisin C attenuated the activity of PMA-activated neutrophil particulate NADPH oxidase in a concentration-dependent manner. 5. Gomisin C reduced the elevations of cytosolic free Ca2+ in neutrophils stimulated by FMLP in the presence or absence of EDTA. Cyclopiazonic acid (CPA) induced the release of Ca2+ from intracellular stores and this was also reduced by gomisin C. However, the Ca2+ influx pathway activated by CPA was not affected by gomisin C. 6. The cellular cyclic AMP level was markedly increased by forskolin, but not by gomisin C. Moreover, the inositol phosphate levels in FMLP-activated neutrophils were not affected by gomisin C. 7. These results show that the inhibitory action of gomisin C on the respiratory burst is not mediated by changes in cellular cyclic AMP or in inositol phosphates, or by scavenging O2- released from neutrophils, but may be mediated partly by the suppression of NADPH oxidase and partly by the decrease of cytosolic Ca2+ released from an agonist-sensitive intracellular store.

  16. Bifurcations of emergent bursting in a neuronal network.

    Directory of Open Access Journals (Sweden)

    Yu Wu

    Full Text Available Complex neuronal networks are an important tool to help explain paradoxical phenomena observed in biological recordings. Here we present a general approach to mathematically tackle a complex neuronal network so that we can fully understand the underlying mechanisms. Using a previously developed network model of the milk-ejection reflex in oxytocin cells, we show how we can reduce a complex model with many variables and complex network topologies to a tractable model with two variables, while retaining all key qualitative features of the original model. The approach enables us to uncover how emergent synchronous bursting can arise from a neuronal network which embodies known biological features. Surprisingly, the bursting mechanisms are similar to those found in other systems reported in the literature, and illustrate a generic way to exhibit emergent and multiple time scale oscillations at the membrane potential level and the firing rate level.

  17. Bursting neurons and ultrasound avoidance in crickets.

    Science.gov (United States)

    Marsat, Gary; Pollack, Gerald S

    2012-01-01

    Decision making in invertebrates often relies on simple neural circuits composed of only a few identified neurons. The relative simplicity of these circuits makes it possible to identify the key computation and neural properties underlying decisions. In this review, we summarize recent research on the neural basis of ultrasound avoidance in crickets, a response that allows escape from echolocating bats. The key neural property shaping behavioral output is high-frequency bursting of an identified interneuron, AN2, which carries information about ultrasound stimuli from receptor neurons to the brain. AN2's spike train consists of clusters of spikes - bursts - that may be interspersed with isolated, non-burst spikes. AN2 firing is necessary and sufficient to trigger avoidance steering but only high-rate firing, such as occurs in bursts, evokes this response. AN2 bursts are therefore at the core of the computation involved in deciding whether or not to steer away from ultrasound. Bursts in AN2 are triggered by synaptic input from nearly synchronous bursts in ultrasound receptors. Thus the population response at the very first stage of sensory processing - the auditory receptor - already differentiates the features of the stimulus that will trigger a behavioral response from those that will not. Adaptation, both intrinsic to AN2 and within ultrasound receptors, scales the burst-generating features according to the stimulus statistics, thus filtering out background noise and ensuring that bursts occur selectively in response to salient peaks in ultrasound intensity. Furthermore AN2's sensitivity to ultrasound varies adaptively with predation pressure, through both developmental and evolutionary mechanisms. We discuss how this key relationship between bursting and the triggering of avoidance behavior is also observed in other invertebrate systems such as the avoidance of looming visual stimuli in locusts or heat avoidance in beetles.

  18. Methods of rock burst prediction

    Energy Technology Data Exchange (ETDEWEB)

    Genkin, V.A.; Minin, Yu.Ya.; Morozov, G.D.; Proskuryakov, V.M.; Cmirnov, V.A.

    1979-07-01

    Some methods of predicting rock bursts in underground coal and iron ore mines are evaluated: using BP-18 indenters and the MGD indenter with automatic recording; seismic method consisting in measuring the speed of shock waves travelling through various layers (apparatus SB-20 is designed for use in coal mines); electrometric method (measuring resistance between two electrodes when electric currents flow through coal and rocks). The design of the AEhSSh-1 measuring instrument, used in the electrometric method in coal mines is also described. Each of the methods is described and mathematical fomulae used as their theoretical basis are presented. The calculating process is explained and brief information on the design and use of the measuring instrument is given. The methods are evaluated from the viewpoint of precision. (In Russian)

  19. Localization of Gamma-Ray Bursts using the Fermi Gamma-Ray Burst Monitor

    CERN Document Server

    Connaughton, V; Goldstein, A; Meegan, C A; Paciesas, W S; Preece, R D; Wilson-Hodge, C A; Gibby, M H; Greiner, J; Gruber, D; Jenke, P; Kippen, R M; Pelassa, V; Xiong, S; Yu, H -F; Bhat, P N; Burgess, J M; Byrne, D; Fitzpatrick, G; Foley, S; Giles, M M; Guiriec, S; van der Horst, A J; von Kienlin, A; McBreen, S; McGlynn, S; Tierney, D; Zhang, B -B

    2014-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) has detected over 1400 Gamma-Ray Bursts (GRBs) since it began science operations in July, 2008. We use a subset of over 300 GRBs localized by instruments such as Swift, the Fermi Large Area Telescope, INTEGRAL, and MAXI, or through triangulations from the InterPlanetary Network (IPN), to analyze the accuracy of GBM GRB localizations. We find that the reported statistical uncertainties on GBM localizations, which can be as small as 1 degree, underestimate the distance of the GBM positions to the true GRB locations and we attribute this to systematic uncertainties. The distribution of systematic uncertainties is well represented (68% confidence level) by a 3.7 degree Gaussian with a non-Gaussian tail that contains about 10% of GBM-detected GRBs and extends to approximately 14 degrees. A more complex model suggests that there is a dependence of the systematic uncertainty on the position of the GRB in spacecraft coordinates, with GRBs in the quadrants on the Y-axis better l...

  20. LOCALIZATION OF GAMMA-RAY BURSTS USING THE FERMI GAMMA-RAY BURST MONITOR

    Energy Technology Data Exchange (ETDEWEB)

    Connaughton, V.; Briggs, M. S.; Burgess, J. M. [CSPAR and Physics Department, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Goldstein, A.; Wilson-Hodge, C. A. [Astrophysics Office, ZP12, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Meegan, C. A.; Jenke, P.; Pelassa, V.; Xiong, S.; Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Paciesas, W. S. [Universities Space Research Association, Huntsville, AL (United States); Preece, R. D. [Department of Space Science, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H. [Jacobs Technology, Inc., Huntsville, AL (United States); Greiner, J.; Yu, H.-F. [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Kippen, R. M. [Los Alamos National Laboratory, NM 87545 (United States); Byrne, D.; Fitzpatrick, G.; Foley, S., E-mail: valerie@nasa.gov [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); and others

    2015-02-01

    The Fermi Gamma-ray Burst Monitor (GBM) has detected over 1400 gamma-ray bursts (GRBs) since it began science operations in 2008 July. We use a subset of over 300 GRBs localized by instruments such as Swift, the Fermi Large Area Telescope, INTEGRAL, and MAXI, or through triangulations from the InterPlanetary Network, to analyze the accuracy of GBM GRB localizations. We find that the reported statistical uncertainties on GBM localizations, which can be as small as 1°, underestimate the distance of the GBM positions to the true GRB locations and we attribute this to systematic uncertainties. The distribution of systematic uncertainties is well represented (68% confidence level) by a 3.°7 Gaussian with a non-Gaussian tail that contains about 10% of GBM-detected GRBs and extends to approximately 14°. A more complex model suggests that there is a dependence of the systematic uncertainty on the position of the GRB in spacecraft coordinates, with GRBs in the quadrants on the Y axis better localized than those on the X axis.

  1. CT findings predictive of neurological deficits in throracolumbar burst fractures

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Tae Yong; Jeong, Hee Seok; Jeong, Yeo Jin [Pusan National University and Research Institute for Convergence of Biomedical Science and Technology, Dept. of Radiology, Pusan National University Yangsan Hospital, Yangsan (Korea, Republic of); Lee, In Sook [Dept. of Radiology, Pusan National University Hospital, Busan (Korea, Republic of)

    2016-09-15

    To determine the computed tomography (CT) findings predictive of neurological deficits in thoracolumbar spine injuries. One hundred two patients with thoracolumbar spinal burst fractures, after excluding the patients with brain and cervical cord injuries and unconsciousness, who underwent consecutive spine 128-multidetector CT scan formed the study group. The neurological findings were clinically classified as no deficit (n = 58), complete deficit with paraplegia (n = 22), and incomplete deficit with either motor or sensory impairment (n = 22). The following four CT imaging parameters were analyzed: the level of the main burst fracture as the cord (n = 44) and the cauda equina (n = 58) levels; the extent of canal encroachment as central canal ratios (CCRs) below 0.5 (n = 43) and above 0.5 (n = 59); the degree of laminar fracture as no fracture (n = 33), linear fracture (n = 7), separated fracture (n = 27), and displaced fracture (n = 35); fractured vertebra counted as single (n = 53) and multiple (n = 49). Complete neurological deficit was associated with injuries at the cord level (p = 0.000) and displaced laminar fractures (p = 0.000); incomplete neurological deficit was associated with CCRs below 0.5 (p = 0.000) and multiple vertebral injuries (p = 0.002). CT scan can provide additional findings predictive of neurological deficits in thoracolumbar spinal burst fractures.

  2. Observational properties of decameter type IV bursts

    Science.gov (United States)

    Melnik, Valentin; Brazhenko, Anatoly; Rucker, Helmut; Konovalenko, Alexander; Briand, Carine; Dorovskyy, Vladimir; Zarka, Philippe; Frantzusenko, Anatoly; Panchenko, Michael; Poedts, Stefan; Zaqarashvili, Teimuraz; Shergelashvili, Bidzina

    2013-04-01

    Oscillations of decameter type IV bursts were registered during observations of solar radio emission by UTR-2, URAN-2 and NDA in 2011-2012. Large majority of these bursts were accompanied by coronal mass ejections (CMEs), which were observed by SOHO and STEREO in the visible light. Only in some cases decameter type IV bursts were not associated with CMEs. The largest periods of oscillations P were some tens of minutes. There were some modes of long periods of oscillations simultaneously. Periods of oscillations in flux and in polarization profiles were close. Detailed properties of oscillations at different frequencies were analyzed on the example of two type IV bursts. One of them was observed on April 7, 2011 when a CME happened. Another one (August 1, 2011) was registered without any CME. The 7 April type IV burst had two periods in the frames 75-85 and 35-85 minutes. Interesting feature of these oscillations is decreasing periods with time. The observed decreasing rates dP/dt equaled 0.03-0.07. Concerning type IV burst observed on August 1, 2011 the period of its oscillations increases from 17 min. at 30 MHz to 44 min. at 10 MHz. Connection of type IV burst oscillations with oscillations of magnetic arches and CMEs at corresponding altitudes are discussed. The work is fulfilled in the frame of FP7 project "SOLSPANET".

  3. Microseismic Precursory Characteristics of Rock Burst Hazard in Mining Areas Near a Large Residual Coal Pillar: A Case Study from Xuzhuang Coal Mine, Xuzhou, China

    Science.gov (United States)

    Cao, An-ye; Dou, Lin-ming; Wang, Chang-bin; Yao, Xiao-xiao; Dong, Jing-yuan; Gu, Yu

    2016-11-01

    Identification of precursory characteristics is a key issue for rock burst prevention. The aim of this research is to provide a reference for assessing rock burst risk and determining potential rock burst risk areas in coal mining. In this work, the microseismic multidimensional information for the identification of rock bursts and spatial-temporal pre-warning was investigated in a specific coalface which suffered high rock burst risk in a mining area near a large residual coal pillar. Firstly, microseismicity evolution prior to a disastrous rock burst was qualitatively analysed, and the abnormal clustering of seismic sources, abnormal variations in daily total energy release, and event counts can be regarded as precursors to rock burst. Secondly, passive tomographic imaging has been used to locate high seismic activity zones and assess rock burst hazard when the coalface passes through residual pillar areas. The results show that high-velocity or velocity anomaly regions correlated well with strong seismic activities in future mining periods and that passive tomography has the potential to describe, both quantitatively and periodically, hazardous regions and assess rock burst risk. Finally, the bursting strain energy index was further used for short-term spatial-temporal pre-warning of rock bursts. The temporal sequence curve and spatial contour nephograms indicate that the status of the danger and the specific hazardous zones, and levels of rock burst risk can be quantitatively and rapidly analysed in short time and in space. The multidimensional precursory characteristic identification of rock bursts, including qualitative analysis, intermediate and short-time quantitative predictions, can guide the choice of measures implemented to control rock bursts in the field, and provides a new approach to monitor and forecast rock bursts in space and time.

  4. Bursting neurons and ultrasound avoidance in crickets

    Directory of Open Access Journals (Sweden)

    Gary eMarsat

    2012-07-01

    Full Text Available Decision making in invertebrates often relies on simple neural circuits composed of only a few identified neurons. The relative simplicity of these circuits makes it possible to identify the key computation and neural properties underlying decisions. In this review, we summarize recent research on the neural basis of ultrasound avoidance in crickets, a response that allows escape from echolocating bats. The key neural property shaping behavioral output is high-frequency bursting of an identified interneuron, AN2, which carries information about ultrasound stimuli from receptor neurons to the brain. AN2's spike train consists of clusters of spikes –bursts– that may be interspersed with isolated, non-burst spikes. AN2 firing is necessary and sufficient to trigger avoidance steering but only high-rate firing, such as occurs in bursts, evokes this response. AN2 bursts are therefore at the core of the computation involved in deciding whether or not to steer away from ultrasound. Bursts in AN2 are triggered by synaptic input from nearly synchronous bursts in ultrasound receptors. Thus the population response at the very first stage of sensory processing –the auditory receptor- already differentiates the features of the stimulus that will trigger a behavioral response from those that will not. Adaptation, both intrinsic to AN2 and within ultrasound receptors, scales the burst-generating features according to the stimulus statistics, thus filtering out background noise and ensuring that bursts occur selectively in response to salient peaks in ultrasound intensity. Furthermore AN2’s sensitivity to ultrasound varies adaptively with predation pressure, through both developmental and evolutionary mechanisms. We discuss how this key relationship between bursting and the triggering of avoidance behavior is also observed in other invertebrate systems such as the avoidance of looming visual stimuli in locusts or heat avoidance in beetles.

  5. The Arecibo Fast Radio Burst: Dense Circum-burst Medium

    CERN Document Server

    Kulkarni, S R; Neill, J D

    2015-01-01

    The nature of fast radio bursts (FRB) has been extensively debated. Here we investigate FRB121102, detected at Arecibo telescope and remarkable for its unusually large spectral index. After extensive study we conclude that the spectral index is caused by a nebula with free-free absorption. We find that putative nebula must lie beyond the Milky Way. We conclude that FRBs are of extra-galactic origin and that they arise in dense star-forming regions. The challenge with extra-galactic models is the the high volumetric rate of FRBs. This high rate allows us to eliminate all models of catastrophic stellar deaths. Hyper-giant flares from young magnetars emerge as the most likely progenitors. Some of the consequences are: (i) Intergalactic FRB models can be safely ignored. (ii) The rich ISM environment of young magnetars can result in significant contribution to DM, Rotation Measure (RM) and in some cases to significant free-free optical depth. (iii) The star-forming regions in the host galaxies can contribute signi...

  6. Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis

    Directory of Open Access Journals (Sweden)

    Kazuhisa Ouhara

    2012-03-01

    Full Text Available Background:IL-32 was recently found to be elevated in the tissue of rheumatoid arthritis and inflammatory bowel disease. Periodontitis is a chronic inflammatory disease caused by polymicrobial infections that result in soft tissue destruction and alveolar bone loss. Although IL-32 is also thought to be associated with periodontal disease, its expression and possible role in periodontal tissue remain unclear. Therefore, this study investigated the expression patterns of IL-32 in healthy and periodontally diseased gingival tissue. The expression of IL-32 in cultured human gingival fibroblasts (HGF as well as effects of autocrine IL-32 on IL-8 production from HGF were also examined.Methods:Periodontal tissue was collected from both healthy volunteers and periodontitis patients, and immunofluorescent staining was performed in order to determine the production of IL-32. Using real-time PCR and ELISA, mRNA expression and protein production of IL-32 in HGF, stimulated by Porphyromonas gingivalis (Pg, were also investigated.Results:Contrary to our expectation, the production of IL-32 in the periodontitis patients was significantly lower than in the healthy volunteers. According to immunofluorescent microscopy, positive staining for IL-32 was detected in prickle and basal cell layers in the epithelium as well as fibroblastic cells in connective tissue. Addition of fixed Pg in vitro was found to suppress the otherwise constitutive expression of IL-32 mRNA and protein in HGF. However, recombinant IL-32 in vitro inhibited the expression of IL-8 mRNA by HGF stimulated with Pg. Interestingly, anti-IL-32 neutralizing antibody upregulated the IL-8 mRNA expression in non-stimulated HGF, indicating that constitutive expression of IL-32 in HGF suppressed IL-8 mRNA expression in the absence of bacterial stimulation.Conclusion:These results indicate that IL-32 is constitutively produced by HGF which can be suppressed by Pg and may play a role in the downregulation

  7. Bursts of star formation in computer simulations of dwarf galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Comins, N.F.

    1984-09-01

    A three-dimensional Stochastic Self-Propagating Star Formation (SSPSF) model of compact galacies is presented. Two phases of gas, active and inactive, are present, and permanent depletion of gas in the form of long lived, low mass stars and remnants occurs. Similarly, global infall of gas from a galactic halo or through galactic cannibalism is permitted. We base our parameters on the observed properties of the compact blue galaxy I Zw 36. Our results are that bursts of star formation occur much more frequently in these runs than continuous nonbursting star formation, suggesting that the blue compact galaxies are probably undergoing bursts rather than continuous, nonbursting low-level star formation activity.

  8. Neutrino bursts from Fanaroff-Riley I radio galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Anchordoqui, Luis A. [Department of Physics, Northeastern University, Boston, MA 02155 (United States); Goldberg, Haim [Department of Physics, Northeastern University, Boston, MA 02155 (United States)]. E-mail: goldberg@neu.edu; Halzen, Francis [Department of Physics, University of Wisconsin, Madison, WI 53706 (United States); Weiler, Thomas J. [Theory Division, CERN, CH-1211 Geneva 23 (Switzerland); Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235 (United States)

    2004-10-28

    On the basis of existing observations (at the 4.5{sigma} level) of TeV {gamma}-ray outbursts from the Fanaroff-Riley I (FRI) radio galaxy Centaurus A, we estimate the accompanying neutrino flux in a scenario where both photons and neutrinos emerge from pion decay. We find a neutrino flux on Earth dF{sub {nu}}/dE{sub {nu}}=(4.5x10{sup -11})(E{sub {nu}}/ TeV){sup -2} TeV{sup -1}cm{sup -2}s{sup -1}, equally spread in flavor as a result of maximal mixing. Such a flux will trigger at the IceCube facility about 10 showers/burst, with negligible background from atmospheric muons, and primary neutrino energies in excess of 100 TeV. The only other FRI radio galaxy observed in the TeV photon energy range at the 4{sigma} level is M87. The burst nature of this activity is not established; however, we show that the intrinsic neutrino luminosity during the active period is the same as the Centaurus A burst. On the assumption that Centaurus A typifies the FRI population, we show that IceCube should collect 10 showers (all neutrino flavors) in 3 years, attaining a 95% CL sensitivity to the diffuse neutrino flux from FRI radio galaxies in one year of observation.

  9. ESTIMATE OF BURSTING PRESSURE OF MILD STEEL PRESSURE VESSEL AND PRESENTATION OF BURSTING FORMULA

    Institute of Scientific and Technical Information of China (English)

    ZHENG Chuanxiang

    2006-01-01

    In order to get more precise bursting pressure formula of mild steel, hundreds of bursting experiments of mild steel pressure vessels such as Q235(Gr.D) and 20R(1020) are done. Based on statistical data of bursting pressure and modification of Faupel formula, a more precise modified formula is given out according to the experimental data. It is proved to be more accurate after examining other bursting pressure value presented in many references. This bursting formula is very accurate in these experiments using pressure vessels with different diameter and shell thickness.Obviously, this modified bursting formula can be used in mild steel pressure vessels with different diameter and thickness of shell.

  10. Gamma-ray Burst Cosmology

    CERN Document Server

    Wang, F Y; Liang, E W

    2015-01-01

    Gamma-ray bursts (GRBs) are the most luminous electromagnetic explosions in the Universe, which emit up to $8.8\\times10^{54}$ erg isotropic equivalent energy in the hard X-ray band. The high luminosity makes them detectable out to the largest distances yet explored in the Universe. GRBs, as bright beacons in the deep Universe, would be the ideal tool to probe the properties of high-redshift universe: including the cosmic expansion and dark energy, star formation rate, the reionization epoch and the metal enrichment history of the Universe. In this article, we review the luminosity correlations of GRBs, and implications for constraining the cosmological parameters and dark energy. Observations show that the progenitors of long GRBs are massive stars. So it is expected that long GRBs are tracers of star formation rate. We also review the high-redshift star formation rate derived from GRBs, and implications for the cosmic reionization history. The afterglows of GRBs generally have broken power-law spectra, so it...

  11. Gamma-ray burst progenitors

    CERN Document Server

    Levan, Andrew; de Grijs, Richard; Langer, Norbert; Xu, Dong; Yoon, Sung-Chul

    2016-01-01

    We review our current understanding of the progenitors of both long and short duration gamma-ray bursts (GRBs). Constraints can be derived from multiple directions, and we use three distinct strands; i) direct observations of GRBs and their host galaxies, ii) parameters derived from modeling, both via population synthesis and direct numerical simulation and iii) our understanding of plausible analog progenitor systems observed in the local Universe. From these joint constraints, we describe the likely routes that can drive massive stars to the creation of long GRBs, and our best estimates of the scenarios that can create compact object binaries which will ultimately form short GRBs, as well as the associated rates of both long and short GRBs. We further discuss how different the progenitors may be in the case of black hole engine or millisecond-magnetar models for the production of GRBs, and how central engines may provide a unifying theme between many classes of extremely luminous transient, from luminous an...

  12. Gamma-Ray Burst Progenitors

    Science.gov (United States)

    Levan, Andrew; Crowther, Paul; de Grijs, Richard; Langer, Norbert; Xu, Dong; Yoon, Sung-Chul

    2016-12-01

    We review our current understanding of the progenitors of both long and short duration gamma-ray bursts (GRBs). Constraints can be derived from multiple directions, and we use three distinct strands; (i) direct observations of GRBs and their host galaxies, (ii) parameters derived from modelling, both via population synthesis and direct numerical simulation and (iii) our understanding of plausible analog progenitor systems observed in the local Universe. From these joint constraints, we describe the likely routes that can drive massive stars to the creation of long GRBs, and our best estimates of the scenarios that can create compact object binaries which will ultimately form short GRBs, as well as the associated rates of both long and short GRBs. We further discuss how different the progenitors may be in the case of black hole engine or millisecond-magnetar models for the production of GRBs, and how central engines may provide a unifying theme between many classes of extremely luminous transient, from luminous and super-luminous supernovae to long and short GRBs.

  13. Long Burst Error Correcting Codes Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Long burst error mitigation is an enabling technology for the use of Ka band for high rate commercial and government users. Multiple NASA, government, and commercial...

  14. FRBCAT: The Fast Radio Burst Catalogue

    CERN Document Server

    Petroff, E; Jameson, A; Keane, E F; Bailes, M; Kramer, M; Morello, V; Tabbara, D; van Straten, W

    2016-01-01

    Here we present a catalogue of known Fast Radio Burst (FRB) sources in the form of an online catalogue, FRBCAT. The catalogue includes information about the instrumentation used for the observations for each detected burst, the measured quantities from each observation, and model-dependent quantities derived from observed quantities. To aid in consistent comparisons of burst properties such as width and signal-to-noise ratios we have reprocessed all the bursts for which we have access to the raw data, with software which we make available. The originally derived properties are also listed for comparison. The catalogue is hosted online as a MySQL database which can also be downloaded in tabular or plain text format for off-line use. This database will be maintained for use by the community for studies of the FRB population as it grows.

  15. CMEs and frequency cutoff of solar bursts

    Science.gov (United States)

    Stanislavsky, Al.; Konovalenko, Al.; Koval, Ar.; Volvach, Y.; Zarka, P.

    2016-05-01

    Radio observations of solar bursts with high-frequency cutoff by the radio telescope UTR-2 (near Kharkiv, Ukraine) at 8-33 MHz on 17-19 August 2012 are presented. Such cutoff may be attributed to the emergence of the burst sources behind limb of the Sun with respect to an observer on the Earth. The events are strongly associated with solar eruptions occurred in a new active region. Ray tracing simulations show that the CMEs play a constructive role for the behind-limb bursts to be detected in ground-based observations. Likely, due to tunnel-like cavities with low density in CMEs, the radio emission of behind-limb solar bursts can be directed towards the Earth.

  16. GLAST Burst Monitor Trigger Classification Algorithm

    Science.gov (United States)

    Perrin, D. J.; Sidman, E. D.; Meegan, C. A.; Briggs, M. S.; Connaughton, V.

    2004-01-01

    The Gamma Ray Large Area Space Telescope (GLAST), currently set for launch in the first quarter of 2007, will consist of two instruments, the GLAST Burst Monitor (GBM) and the Large Area Telescope (LAT). One of the goals of the GBM is to identify and locate gamma-ray bursts using on-board software. The GLAST observatory can then be re-oriented to allow observations by the LAT. A Bayesian analysis will be used to distinguish gamma-ray bursts from other triggering events, such as solar flares, magnetospheric particle precipitation, soft gamma repeaters (SGRs), and Cygnus X-1 flaring. The trigger parameters used in the analysis are the burst celestial coordinates, angle from the Earth's horizon, spectral hardness, and the spacecraft geomagnetic latitude. The algorithm will be described and the results of testing will be presented.

  17. Bursts from the very early universe

    Energy Technology Data Exchange (ETDEWEB)

    Silk, J. [Department of Physics, University of Oxford, Oxford OX1 3RH (United Kingdom); Stodolsky, L. [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Munich (Germany)]. E-mail: les@mppmu.mpg.de

    2006-07-27

    Bursts of weakly interacting particles such as neutrinos or even more weakly interacting particles such as wimps and gravitons from the very early universe would offer a much deeper 'look back time' to early epochs than is possible with photons. We consider some of the issues related to the existence of such bursts and their detectability. Characterizing the burst rate by a probability P per Hubble four-volume we find, for events in the radiation-dominated era, that the natural unit of description is the present intensity of the CMB times P. The existence of such bursts would make the observation of pheno associated with very early times in cosmology at least conceptually possible. One might even hope to probe the transplanckian epoch if complexes more weakly interacting than the graviton can exist. Other conceivable applications include the potential detectability of the formation of 'pocket universes' in a multiverse.

  18. Expected Performance of the GLAST Burst Monitor

    Science.gov (United States)

    Meegan, Charles; Fishman, Gerald; Kouveliotou, Chryssa; Wilson-Hodge, Colleen; Paciesas, William; Preece, Robert; Briggs, Michael; Bhat, Narayana; Connaughton, Valerie; Greiner, Jochen; vonKienlin, Andreas; Diehl, Roland; Steinle, Helmut; Bissaldi, Elisabetta; Kippen, R. Marc

    2007-01-01

    The GLAST Burst Monitor (GBM) will enhance LAT observations of GRBs by extending the spectral coverage from the LAT threshold down to approx. 8 kev, and will provide a trigger for re-orienting the spacecraft to observe delayed emission from selected bursts outside the LAT field of view. GBM consists of twelve NaI scintillation detectors operating in the 8 kev to 1 MeV energy range and two BGO scintillation detectors operating in the 150 keV to 30 MeV energy range. Detector resolution, effective area, and angular response have been determined by calibrations. Analyses indicate that the on-board burst threshold will be approx. 0.7 photon/cm2/s and the on-board burst localization accuracy will typically be better than 8 degrees.

  19. Plasma Bursts in Deep Penetration Laser Welding

    Science.gov (United States)

    Mrňa, L.; Šarbort, M.

    We present an experimental study of the deep penetration laser welding process which aims to analyze the plasma plume oscillations on a short time scale. Using the high-speed camera we show that the plasma comes out of the keyhole in the form of short bursts rather than the continuous flow. We detect these bursts as the short-time intensity oscillations of light emissions coming from the plasma plume. We determine the period of bursts using the statistical signal processing methods and the short-time frequency analysis. Finally, we compare the characteristics of plasma bursts and the geometry of resulting welds carried out on a 2 kW Yb:YAG laser welding machine for the steel workpiece and various welding parameters settings.

  20. Research on experiment and calculation of foam bursting device

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This research presents experimental data on mechanical foam bursting device, based on the high speed of air fluid impinging insidethe foam bursting device, foam bubbles disrupted as a consequence of pressures changed very quickly as shear force and their impact forces. Experimental data on foam-bursting capacity have been presented. Designed device can provide effective foam bursting on collapse foam.

  1. The Five Year Fermi/GBM Magnetar Burst Catalog

    NARCIS (Netherlands)

    A.C. Collazzi; C. Kouveliotou; A.J. van der Horst; G.A. Younes; Y. Kaneko; E. Göğüş; L. Lin; J. Granot; M.H. Finger; V.L. Chaplin; D. Huppenkothen; A.L. Watts; A. von Kienlin; M.G. Baring; D. Gruber; P.N. Bhat; M.H. Gibby; N. Gehrels; J. Mcenery; M. van der Klis; R.A.M.J. Wijers

    2015-01-01

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present

  2. Optimal Codes for the Burst Erasure Channel

    Science.gov (United States)

    Hamkins, Jon

    2010-01-01

    Deep space communications over noisy channels lead to certain packets that are not decodable. These packets leave gaps, or bursts of erasures, in the data stream. Burst erasure correcting codes overcome this problem. These are forward erasure correcting codes that allow one to recover the missing gaps of data. Much of the recent work on this topic concentrated on Low-Density Parity-Check (LDPC) codes. These are more complicated to encode and decode than Single Parity Check (SPC) codes or Reed-Solomon (RS) codes, and so far have not been able to achieve the theoretical limit for burst erasure protection. A block interleaved maximum distance separable (MDS) code (e.g., an SPC or RS code) offers near-optimal burst erasure protection, in the sense that no other scheme of equal total transmission length and code rate could improve the guaranteed correctible burst erasure length by more than one symbol. The optimality does not depend on the length of the code, i.e., a short MDS code block interleaved to a given length would perform as well as a longer MDS code interleaved to the same overall length. As a result, this approach offers lower decoding complexity with better burst erasure protection compared to other recent designs for the burst erasure channel (e.g., LDPC codes). A limitation of the design is its lack of robustness to channels that have impairments other than burst erasures (e.g., additive white Gaussian noise), making its application best suited for correcting data erasures in layers above the physical layer. The efficiency of a burst erasure code is the length of its burst erasure correction capability divided by the theoretical upper limit on this length. The inefficiency is one minus the efficiency. The illustration compares the inefficiency of interleaved RS codes to Quasi-Cyclic (QC) LDPC codes, Euclidean Geometry (EG) LDPC codes, extended Irregular Repeat Accumulate (eIRA) codes, array codes, and random LDPC codes previously proposed for burst erasure

  3. Syudy of Token Generation for Burst Traffic Shaping in Optical Burst Switching Networks

    Institute of Scientific and Technical Information of China (English)

    Tang Wan; So Won-ho; Lu Ji-guang; Kim Young-chon

    2004-01-01

    Traffic shaping is one of important control operation to guarantee the Quality of Service (QoS) in optical burst switching (OBS) networks. The efficiency of traffic shaping is mainly determined by token generation method. In this paper, token generation methods of traffic shaping are evaluated by using three kinds of probability distribution, and are analyzed in terms of burst blocking probability, throughput and correlation by simulation. The simulation results show that the token generation methods decrease the burst correlation of Label Switched Paths (LSPs), and solve traffic congestion as well. The different burst arrival processes have small impact on the blocking probability for OBS networks.

  4. QoS-guaranteed burst transmission for VoIP service over optical burst switching networks

    Science.gov (United States)

    Tachibana, Takuji; Kasahara, Shoji

    2007-08-01

    We propose a burst transmission method that guarantees the voice over Internet protocol (VoIP) service. The proposed method consists of three techniques: round-robin burst assembly with slotted scheduling, priority control with void filling, and hop-based preemption. Each technique is utilized so that the burst loss probability and the burst transmission delay satisfy VoIP quality of service (QoS). We evaluate by simulation the performance of the proposed method in NSFNET with 14 nodes. Numerical examples show that our proposed method is effective for guaranteeing the VoIP QoS while accommodating a large number of VoIP users.

  5. A Remarkable Angular Distribution of the Intermediate Subclass of $\\gamma$-Ray Bursts

    CERN Document Server

    Mészáros, A; Horváth, I L; Balázs, L; Vavrek, R; Meszaros, Attila; Bagoly, Zsolt; Horvath, Istvan; Balazs, Lajos G.

    2000-01-01

    In the article a test is developed, which allows to test the null-hypothesis of the intrinsic randomness in the angular distribution of gamma-ray bursts collected at the Current BATSE Catalog. The method is a modified version of the well-known counts-in-cells test, and fully eliminates the non-uniform sky-exposure function of BATSE instrument. Applying this method to the case of all gamma-ray bursts no intrinsic non-randomness was found. The test also did not find intrinsic non-randomnesses for the short and long gamma-ray bursts, respectively. On the other hand, using the method to the new intermediate subclass of gamma-ray bursts, the null-hypothesis of the intrinsic randomness for 181 intermediate gamma-ray bursts is rejected on the 96.4% confidence level. Taking 92 dimmer bursts from this subclass itself, we obtain the surprising result: This "dim" subclass of the intermediate subclass has an intrinsic non-randomness on the 99.3% confidence level. On the other hand, the 89 "bright" GRBs show no intrinsic ...

  6. Gamma-Ray Burst Class Properties

    Science.gov (United States)

    Hakkila, Jon; Haglin, David J.; Pendleton, Geoffrey N.; Mallozzi, Robert S.; Meegan, Charles A.; Roiger, Richard J.

    2000-01-01

    Guided by the supervised pattern recognition algorithm C4.5 developed by Quinlan in 1986, we examine the three gamma-ray burst classes identified by Mukherjee et al. in 1998. C4.5 provides strong statistical support for this classification. However, with C4.5 and our knowledge of the Burst and Transient Source Experiment (BATSE) instrument, we demonstrate that class 3 (intermediate fluence, intermediate duration, soft) does not have to be a distinct source population: statistical/systematic errors in measuring burst attributes combined with the well-known hardness/intensity correlation can cause low peak flux class 1 (high fluence, long, intermediate hardness) bursts to take on class 3 characteristics naturally. Based on our hypothesis that the third class is not a distinct one, we provide rules so that future events can be placed in either class 1 or class 2 (low fluence, short, hard). We find that the two classes are relatively distinct on the basis of Band's work in 1993 on spectral parameters alpha, beta, and E (sub peak) alone. Although this does not indicate a better basis for classification, it does suggest that different physical conditions exist for class 1 and class 2 bursts. In the process of studying burst class characteristics, we identify a new bias affecting burst fluence and duration measurements. Using a simple model of how burst duration can be underestimated, we show how this fluence duration bias can affect BATSE measurements and demonstrate the type of effect it can have on the BATSE fluence versus peak flux diagram.

  7. The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.

    LENUS (Irish Health Repository)

    Swanton, B J

    2012-02-03

    BACKGROUND AND OBJECTIVE: Respiratory burst is an essential component of the neutrophil\\'s biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction\\/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. METHODS: Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 microg kg-1), thiopental (4-6 mg kg-1), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg-1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine\\/saline. RESULTS: Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +\\/- 8.2% (group L) and 88.5 +\\/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +\\/- 23.6%) and after (94.4 +\\/- 16.6%) tracheal intubation. CONCLUSION: Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.

  8. Phase analysis method for burst onset prediction

    Science.gov (United States)

    Stellino, Flavio; Mazzoni, Alberto; Storace, Marco

    2017-02-01

    The response of bursting neurons to fluctuating inputs is usually hard to predict, due to their strong nonlinearity. For the same reason, decoding the injected stimulus from the activity of a bursting neuron is generally difficult. In this paper we propose a method describing (for neuron models) a mechanism of phase coding relating the burst onsets with the phase profile of the input current. This relation suggests that burst onset may provide a way for postsynaptic neurons to track the input phase. Moreover, we define a method of phase decoding to solve the inverse problem and estimate the likelihood of burst onset given the input state. Both methods are presented here in a unified framework, describing a complete coding-decoding procedure. This procedure is tested by using different neuron models, stimulated with different inputs (stochastic, sinusoidal, up, and down states). The results obtained show the efficacy and broad range of application of the proposed methods. Possible applications range from the study of sensory information processing, in which phase-of-firing codes are known to play a crucial role, to clinical applications such as deep brain stimulation, helping to design stimuli in order to trigger or prevent neural bursting.

  9. Time Resolved Spectroscopy of SGR J1550-5418 Bursts Detected with Fermi/Gamma-Ray Burst Monitor

    NARCIS (Netherlands)

    Younes, G.; Kouveliotou, C.; van der Horst, A.J.; Baring, M.G.; Granot, J.; Watts, A.L.; Bhat, P.N.; Collazzi, A.; Gehrels, N.; Gorgone, N.; Göğüş, E.; Gruber, D.; Grunblatt, S.; Huppenkothen, D.; Kaneko, Y.; von Kienlin, A.; van der Klis, M.; Lin, L.; Mcenery, J.; van Putten, T.; Wijers, R.A.M.J.

    2014-01-01

    We report on a time-resolved spectroscopy of the 63 brightest bursts of SGR J1550-5418, detected with the Fermi/Gamma-ray Burst Monitor during its 2008-2009 intense bursting episode. We performed spectral analysis down to 4 ms timescales to characterize the spectral evolution of the bursts. Using a

  10. Neuronal networks and energy bursts in epilepsy.

    Science.gov (United States)

    Wu, Y; Liu, D; Song, Z

    2015-02-26

    Epilepsy can be defined as the abnormal activities of neurons. The occurrence, propagation and termination of epileptic seizures rely on the networks of neuronal cells that are connected through both synaptic- and non-synaptic interactions. These complicated interactions contain the modified functions of normal neurons and glias as well as the mediation of excitatory and inhibitory mechanisms with feedback homeostasis. Numerous spread patterns are detected in disparate networks of ictal activities. The cortical-thalamic-cortical loop is present during a general spike wave seizure. The thalamic reticular nucleus (nRT) is the major inhibitory input traversing the region, and the dentate gyrus (DG) controls CA3 excitability. The imbalance between γ-aminobutyric acid (GABA)-ergic inhibition and glutamatergic excitation is the main disorder in epilepsy. Adjustable negative feedback that mediates both inhibitory and excitatory components affects neuronal networks through neurotransmission fluctuation, receptor and transmitter signaling, and through concomitant influences on ion concentrations and field effects. Within a limited dynamic range, neurons slowly adapt to input levels and have a high sensitivity to synaptic changes. The stability of the adapting network depends on the ratio of the adaptation rates of both the excitatory and inhibitory populations. Thus, therapeutic strategies with multiple effects on seizures are required for the treatment of epilepsy, and the therapeutic functions on networks are reviewed here. Based on the high-energy burst theory of epileptic activity, we propose a potential antiepileptic therapeutic strategy to transfer the high energy and extra electricity out of the foci.

  11. DISK-RELATED BURSTS AND FADES IN YOUNG STARS

    Energy Technology Data Exchange (ETDEWEB)

    Findeisen, Krzysztof; Hillenbrand, Lynne; Levitan, David; Sesar, Branimir [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Ofek, Eran [Benoziyo Center for Astrophysics, Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel); Laher, Russ; Surace, Jason, E-mail: krzys@astro.caltech.edu, E-mail: lah@astro.caltech.edu [Spitzer Science Center, California Institute of Technology, MC 314-6, Pasadena, CA 91125 (United States)

    2013-05-01

    We present first results from a new, multiyear, time domain survey of young stars in the North America Nebula complex using the Palomar Transient Factory. Our survey is providing an unprecedented view of aperiodic variability in young stars on timescales of days to years. The analyzed sample covers R{sub PTF} Almost-Equal-To 13.5-18 and spans a range of mid-infrared color, with larger-amplitude optical variables (exceeding 0.4 mag root mean squared) more likely to have mid-infrared evidence for circumstellar material. This paper characterizes infrared excess stars with distinct bursts above or fades below a baseline of lower-level variability, identifying 41 examples. The light curves exhibit a remarkable diversity of amplitudes, timescales, and morphologies, with a continuum of behaviors that cannot be classified into distinct groups. Among the bursters, we identify three particularly promising sources that may represent theoretically predicted short-timescale accretion instabilities. Finally, we find that fading behavior is approximately twice as common as bursting behavior on timescales of days to years, although the bursting and fading duty cycle for individual objects often varies from year to year.

  12. THORACOLUMBAR BURST FRACTURE: STRUCTURAL CHANGES AND CLINICAL OUTCOME OF TREATMENT

    Directory of Open Access Journals (Sweden)

    Rodrigo Arnold Tisot

    2016-03-01

    Full Text Available ABSTRACT Objective: To evaluate the correlation between structural changes in burst fractures of thoracic and lumbar spine with clinical outcome of the treatment. Methods: A retrospective study in 25 patients with fractures of thoracic and lumbar spine burst fractures without neurological deficit. Eleven patients underwent conservative treatment and for the remaining the treatment was surgical. All patients were followed up for at least 24 months. The cases were evaluated by a protocol that included: posttraumatic measurement of kyphosis, vertebral body collapse and narrowing of the spinal canal, the visual analog scale of pain, and the quality of life questionnaire SF-36 at the follow-up. For statistical analysis, the significance level was 5% and the software SPSS 18.0 was used. Results: No statistically significant difference was observed when comparing the clinical outcomes of one treatment over another. Similarly, there was no statistically significant correlation between kyphosis and post-traumatic narrowing of the spinal canal with clinical worsening in the follow-up, regardless of the treatment used. We found a positive correlation (p<0.05 between initial collapse and SF-36 domains in both groups (operated and non-operated. Conclusion: There was no significant superiority of one treatment over the other, and no correlation was found between kyphosis and spinal canal narrowing in burst fractures of the thoracic and lumbar spine without neurological deficit. However, there was correlation between initial collapse and clinical outcome in some domains of the SF-36 questionnaire.

  13. BURST EVENT DETECTION IN WALL TURBULENCE BY WVITA METHOD

    Institute of Scientific and Technical Information of China (English)

    Jiang Nan; Shu Wei; Wang Zhendong

    2000-01-01

    Wavelet Variable Interval Time Average(WVITA)is introduced as a method incorporating burst event detection in wall turbulence.Wavelet transform is performed to unfold the longitudinal fluctuating velocity time series measured in the near wall region of a turbulent boundary layer using hot-film anemometer.This unfolding is both in time and in space simultaneously.The splitted kinetic of the longitudinal fluctuating velocity time series among different scales is obtained by integrating the square of wavelet coefficient modulus over temporal space.The time scale that related to burst events in wall turbulence passing through the fixed probe is ascertained by maximum criterion of the kinetic energy evolution across scales.Wavelet transformed localized variance of the fluctuating velocity time series at the maximum kinetic scale is put forward instead of localized short time average variance in Variable Interval Time Average(VITA)scheme.The burst event detection result shows that WVITA scheme can avoid erroneous judgement and solve the grouping problem more effectively which is caused by VITA scheme itself and can not be avoided by adjusting the threshold level or changing the short time average interval.

  14. Application of burst vibrothermography to characterize planar vertical cracks

    Science.gov (United States)

    Mendioroz, Arantza; Celorrio, Ricardo; Cifuentes, Ángel; Zatón, Lander; Salazar, Agustín.

    2016-05-01

    We present a method to characterize vertical cracks in a fast way using burst vibrothermography. In this technique the sample is excited by ultrasounds and, at the defect, rubbing of the contacting surfaces produces heat that can be detected as a temperature rise at the surface using an infrared camera. In this work, first we present the solution of the direct problem, i.e., the calculation of the surface temperature distribution produced by a vertical heat source representing a crack excited by an ultrasound burst, and we choose the information that will be used to characterize the crack, namely, one thermogram and one timing-graph. Next we address the inverse problem, consisting of finding the heat source distribution that is responsible for the observed surface temperature. This inverse problem is ill-posed, and a naïve inversion process is unstable. We propose to use three penalty terms, based on zero order Tikhonov and Total Variation functionals and the Lasso method, to stabilize the inversion. By inverting synthetic data, we analyze the performance of the algorithm as a function of the depth of the heat source and we study the effect of the burst duration and noise level in the data on the quality of the reconstructions. Finally, we invert experimental data taken in samples containing calibrated heat sources. The results show that it is possible to characterize vertical cracks down to depths of 6 mm in AISI 304 stainless steel.

  15. Pedicle screw fixation against burst fracture of thoracolumbar vertebrae

    Institute of Scientific and Technical Information of China (English)

    L(U) Fu-xin; HUANG Yong; ZHANG Qiang; SHI Feng-lei; ZHAO Dong-sheng; HU Qiao

    2007-01-01

    Objective: To analyze the application of vertebral pedicle screw fixation in the treatment of burst fracture of thoracolumbar vertebrae.Methods: A total of 48 cases (31 males and 17 females, aged from 18-72 years, mean: 41.3 years) with thoracolumbar vertebrae burst fracture were treated by pedicle screw system since January 2004. According to the AO classification of thoracolumbar vertebrae fracture,there are 36 cases of Type A, 9 of Type B and 3 of Type C.Results: All patients were followed up for 6-25 months (average 12 months ), no secondary nerve root injury, spinal cord injury, loosening or breakage of pedicle screw were observed. The nerve function of 29 patients with cauda equina nerve injury was restored to different degrees. The vertebral body height returned to normal level and posterior process angle was rectified after operation.Conclusions: The vertebral pedicle screw internal fixation was technologically applicable, which can efficiently reposition and stablize the bursting fractured vertabrae,indirectly decompress canalis spinalis, maintain spine stablity, scatter stress of screw system, reduce the risk of loosening or breakage of screw and loss of vertebral height,and prevent the formation of posterior convex after operation.

  16. Modeling gamma-ray bursts

    Science.gov (United States)

    Maxham, Amanda

    Discovered serendipitously in the late 1960s, gamma-ray bursts (GRBs) are huge explosions of energy that happen at cosmological distances. They provide a grand physical playground to those who study them, from relativistic effects such as beaming, jets, shocks and blastwaves to radiation mechanisms such as synchrotron radiation to galatic and stellar populations and history. Through the Swift and Fermi space telescopes dedicated to observing GRBs over a wide range of energies (from keV to GeV), combined with accurate pinpointing that allows ground based follow-up observations in the optical, infrared and radio, a rich tapestry of GRB observations has emerged. The general picture is of a mysterious central engine (CE) probably composed of a black hole or neutron star that ejects relativistic shells of matter into intense magnetic fields. These shells collide and combine, releasing energy in "internal shocks" accounting for the prompt emission and flaring we see and the "external shock" or plowing of the first blastwave into the ambient surrounding medium has well-explained the afterglow radiation. We have developed a shell model code to address the question of how X-ray flares are produced within the framework of the internal shock model. The shell model creates randomized GRB explosions from a central engine with multiple shells and follows those shells as they collide, merge and spread, producing prompt emission and X-ray flares. We have also included a blastwave model, which can constrain X-ray flares and explain the origin of high energy (GeV) emission seen by the Fermi telescope. Evidence suggests that gamma-ray prompt emission and X-ray flares share a common origin and that at least some flares can only be explained by long-lasting central engine activity. We pay special attention to the time history of central engine activity, internal shocks, and observed flares. We calculate the gamma-ray (Swift/BAT band) and X-ray (Swift/XRT band) lightcurves for arbitrary

  17. Method and apparatus for coherent burst ranging

    Science.gov (United States)

    Wachter, E.A.; Fisher, W.G.

    1998-04-28

    A high resolution ranging method is described utilizing a novel modulated waveform, hereafter referred to as coherent burst modulation. In the coherent burst method, high frequency modulation of an acoustic or electromagnetic transmitter, such as a laser, is performed at a modulation frequency. This modulation frequency is transmitted quasi-continuously in the form of interrupted bursts of radiation. Energy from the transmitter is directed onto a target, interacts with the target, and the returning energy is collected. The encoded burst pattern contained in the collected return signal is detected coherently by a receiver that is tuned so as to be principally sensitive to the modulation frequency. The receiver signal is processed to determine target range using both time-of-flight of the burst envelope and phase shift of the high frequency modulation. This approach effectively decouples the maximum unambiguous range and range resolution relationship of earlier methods, thereby allowing high precision ranging to be conducted at arbitrarily long distances using at least one burst of encoded energy. The use of a receiver tuned to the high frequency modulation contained within the coherent burst vastly improves both sensitivity in the detection of the target return signal and rejection of background interferences, such as ambient acoustic or electromagnetic noise. Simultaneous transmission at several energies (or wavelengths) is possible by encoding each energy with a separate modulation frequency or pattern; electronic demodulation at the receiver allows the return pattern for each energy to be monitored independently. Radial velocity of a target can also be determined by monitoring change in phase shift of the return signal as a function of time. 12 figs.

  18. Efficient inhibition of bursts by bursts in the auditory system of crickets.

    Science.gov (United States)

    Marsat, G; Pollack, G S

    2007-06-01

    In crickets, auditory information about ultrasound is carried bilaterally to the brain by the AN2 neurons. The ON1 neuron provides contralateral inhibitory input to AN2, thereby enhancing bilateral contrast between the left and right AN2s, an important cue for sound localization. We examine how the structures of the spike trains of these neurons affect this inhibitory interaction. As previously shown for AN2, ON1 responds to salient peaks in stimulus amplitude with bursts of spikes. Spike bursts, but not isolated spikes, reliably signal the occurrence of specific features of the stimulus. ON1 and AN2 burst at similar times relative to the amplitude envelope of the stimulus, and bursts are more tightly time-locked to stimulus feature than the isolated spikes. As a consequence, spikes that, in the absence of contralateral inhibition, would occur within AN2 bursts are more likely to be preceded by spikes in ON1 (mainly also in bursts) than are isolated AN2 spikes. This leads to a large decrease in the burst rate of the inhibited AN2. We conclude that the match in coding properties of ON1 and AN2 allows contralateral inhibition to be most efficient for those portions of the response that carry the behaviourally relevant information, i.e. for bursts.

  19. X-ray burst-induced spectral variability in 4U 1728-34

    Science.gov (United States)

    Kajava, J. J. E.; Sánchez-Fernández, C.; Kuulkers, E.; Poutanen, J.

    2017-03-01

    Aims: INTEGRAL has been monitoring the Galactic center region for more than a decade. Over this time it has detected hundreds of type-I X-ray bursts from the neutron star low-mass X-ray binary 4U 1728-34, also known as the slow burster. Our aim is to study the connection between the persistent X-ray spectra and the X-ray burst spectra in a broad spectral range. Methods: We performed spectral modeling of the persistent emission and the X-ray burst emission of 4U 1728-34 using data from the INTEGRAL JEM-X and IBIS/ISGRI instruments. Results: We constructed a hardness intensity diagram to track spectral state variations. In the soft state, the energy spectra are characterized by two thermal components likely coming from the accretion disc and the boundary/spreading layer, together with a weak hard X-ray tail that we detect in 4U 1728-34 for the first time in the 40 to 80 keV range. In the hard state, the source is detected up to 200 keV and the spectrum can be described by a thermal Comptonization model plus an additional component: either a powerlaw tail or reflection. By stacking 123 X-ray bursts in the hard state, we detect emission up to 80 keV during the X-ray bursts. We find that during the bursts the emission above 40 keV decreases by a factor of approximately three with respect to the persistent emission level. Conclusions: Our results suggest that the enhanced X-ray burst emission changes the spectral properties of the accretion disc in the hard state. The likely cause is an X-ray burst induced cooling of the electrons in the inner hot flow near the neutron star.

  20. High plasma levels of oxidatively modified low-density lipoproteins are associated with the suppressed expression of immunomodulatory molecules in patients with hematological malignancies

    OpenAIRE

    2015-01-01

    Dyslipidemia is a common feature in immunosuppressed patients, such as kidney and bone marrow transplantation recipients and patients with breast, prostate or gynecological carcinoma or acute lymphoblastic leukemia. In addition, high levels of oxidatively modified low-density lipoproteins (oxLDLs) are closely associated with carcinogenesis. There are, however, no reports on the association between the serum oxLDL levels and the expression of important immunomodulatory molecules in patients wi...

  1. A new burst assembly technique for supporting QoS in optical burst switching networks

    Institute of Scientific and Technical Information of China (English)

    Xiaolong Yang(阳小龙); Mingrui Dang(党明瑞); Youju Mao(毛幼菊); Lemin Li(李乐民)

    2003-01-01

    This letter proposes a new burst assembly technique for supporting QoS in optical burst switching (OBS)networks. It consists of the adaptive-threshold burst assembly mechanism and QoS-based random offset-time scheme. The assembly mechanism, which is fit well to multi-class burst assembly, not only matcheswith IP QoS mechanism based on packet classification, and also utilizes fairly and efficiently assemblycapacity. Based on token-bucket model and burst segment selective discard (BSSD), the offset-time schemecan smooth the traffic to support OBS QoS. The simulation results show that the technique can improvethe performance in terms of packet loss probability (PLP).

  2. An Intelligent Segmented Burst Assembly Mechanism in Optical Burst Switching Networks

    Institute of Scientific and Technical Information of China (English)

    XIE Yi-Yuan; ZHANG Jian-Guo

    2008-01-01

    We focus on the burst assembly mechanism and propose a new intelligent method in which the burst is assembled from several internet protocol (IP) packets in which the number of IP packets is changed according to the traffic load and the burst is segmented into several parts, called the ISOBS mechanism. The average burst assembly time of the ISOBS mechanism decreases as compared with the fixed-assembly-time and fixed-assembly-time-and-length mechanisms. The loss ratio decreases 50% as compared with the general optical burst switching (OBS) mechanism. The last segment can carry high quality of service (QOS) information. We can achieve that the loss ratio of the last segment is almost zero when the traffic load is less than 0.05. When the traffic load is 0.9, the loss ratio of the last segment is 0.0041. The ISOBS can support to transmit different QOS data.

  3. Oligomycin A-induced inhibition of mitochondrial ATP-synthase activity suppresses boar sperm motility and in vitro capacitation achievement without modifying overall sperm energy levels.

    Science.gov (United States)

    Ramió-Lluch, Laura; Yeste, Marc; Fernández-Novell, Josep M; Estrada, Efrén; Rocha, Luiz; Cebrián-Pérez, José A; Muiño-Blanco, Teresa; Concha, Ilona I; Ramírez, Alfredo; Rodríguez-Gil, Joan E

    2014-01-01

    Incubation of boar spermatozoa in a capacitation medium with oligomycin A, a specific inhibitor of the F0 component of the mitochondrial ATP synthase, induced an immediate and almost complete immobilisation of cells. Oligomycin A also inhibited the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), as measured through IVC-compatible changes in motility patterns, tyrosine phosphorylation levels of the acrosomal p32 protein, membrane fluidity and the ability of spermatozoa to achieve subsequent, progesterone-induced in vitro acrosome exocytosis (IVAE). Both inhibitory effects were caused without changes in the rhythm of O2 consumption, intracellular ATP levels or mitochondrial membrane potential (MMP). IVAE was accompanied by a fast and intense peak in O2 consumption and ATP levels in control spermatozoa. Oligomycin A also inhibited progesterone-induced IVAE as well as the concomitant peaks of O2 consumption and ATP levels. The effect of oligomycin on IVAE was also accompanied by concomitant alterations in the IVAE-induced changes on intracellular Ca(2+) levels and MMP. Our results suggest that the oligomycin A-sensitive mitochondrial ATP-synthase activity is instrumental in the achievement of an adequate boar sperm motion pattern, IVC and IVAE. However, this effect seems not to be linked to changes in the overall maintenance of adequate energy levels in stages other than IVAE.

  4. The Cosmic Gamma-Ray Bursts

    CERN Document Server

    Djorgovski, S G; Kulkarni, S R; Sari, R; Bloom, J S; Galama, T J; Harrison, F A; Price, P A; Fox, D; Reichart, D; Yost, S; Berger, E; Diercks, A H; Goodrich, R; Chaffee, F H

    2001-01-01

    Cosmic gamma-ray bursts are one of the great frontiers of astrophysics today. They are a playground of relativists and observers alike. They may teach us about the death of stars and the birth of black holes, the physics in extreme conditions, and help us probe star formation in the distant and obscured universe. In this review we summarise some of the remarkable progress in this field over the past few years. While the nature of the GRB progenitors is still unsettled, it now appears likely that at least some bursts originate in explosions of very massive stars, or at least occur in or near the regions of massive star formation. The physics of the burst afterglows is reasonably well understood, and has been tested and confirmed very well by the observations. Bursts are found to be beamed, but with a broad range of jet opening angles; the mean gamma-ray energies after the beaming corrections are ~ 10^51 erg. Bursts are associated with faint ~ 25 mag) galaxies at cosmological redshifts, with ~ 1. The host gal...

  5. Diagnostics From Three Rising Submillimeter Bursts

    CERN Document Server

    Zhou, Ai-Hua; Wang, Xin-Dong

    2015-01-01

    In the paper we investigate three novel rising submillimeter (THz) bursts occurred sequentially in a super-Active Region NOAA 10486. The average rising rate of the flux density above 200 GHz is only 20 sfu/GHz (corresponding spectral index $\\alpha$ of 1.6) for the THz spectral components of 2003 October 28 and November 4 bursts, while it can attain values of 235 sfu/GHz ($\\alpha$=4.8) for 2003 November 2 burst. The steeply rising THz spectrum can be produced by a population of high relativistic electrons with a low-energy cutoff of 1 MeV , while it only requires a low-energy cutoff of 30 keV for the two slowly rising THz bursts, via gyrosynchrotron (GS) radiation based on our numerical simulations of burst spectra in the magnetic dipole field case. The electron density variation is much larger in the THz source than that in microwave (MW) one. It is interesting that the THz source radius decreased by 20--50$\\%$ during the decay phase for the three events, but the MW one increased by 28$\\%$ for the 2003 Novemb...

  6. GRB Catalog: Bursts from Vela to Swift

    Science.gov (United States)

    Angelini, L.

    2008-01-01

    Gamma ray burst (GRB) astronomy started when the first event was recorded on July 2, 1967 by Vela 4a and 4b. Since then many missions have flown experiments capable of detecting GRBs. The events collected by these older experiments are mostly available in paper copy, each containing a few ten to a few hundred bursts. No systematic effort in cataloging of these bursts has been available. In some cases the information is unpublished and in others difficult to retrieve. The first major GRB catalog was obtained by GRO with the BATSE experiment. It contains more than 2000 bursts and includes homogeneous information for each of the bursts. With the launch of Swift, the first Gamma-ray/X-ray mission dedicated to the study of GRBs and their afterglows, a wealth of information is collected by the Swift instrument as well as from ground-based telescopes. This talk will describe the efforts to create a comprehensive GRBCAT and its current status and future prospective.

  7. Gamma Ray Burst reverse shock emission in early radio afterglows

    CERN Document Server

    Resmi, Lekshmi

    2016-01-01

    Reverse shock (RS) emission from Gamma Ray Bursts is an important tool in investigating the nature of the ejecta from the central engine. If the ejecta magnetization is not high enough to suppress the RS, a strong RS emission component, usually peaking in the optical/IR band early on, would give important contribution to early afterglow light curves. In the radio band, synchrotron self-absorption may suppress early RS emission, and also delay the RS peak time. In this paper, we calculate the self-absorbed RS emission in the radio band for different dynamical conditions. In particular, we stress that the RS radio emission is subject to self-absorption in both reverse and forward shocks. We calculate the ratio between the reverse to forward shock flux at the RS peak time for different frequencies, which is a measure of the detectability of the RS emission component. We then constrain the range of physical parameters for a detectable RS, in particular the role of magnetization. We notice that unlike optical RS e...

  8. Network burst dynamics under heterogeneous cholinergic modulation of neural firing properties and heterogeneous synaptic connectivity.

    Science.gov (United States)

    Knudstrup, Scott; Zochowski, Michal; Booth, Victoria

    2016-05-01

    The characteristics of neural network activity depend on intrinsic neural properties and synaptic connectivity in the network. In brain networks, both of these properties are critically affected by the type and levels of neuromodulators present. The expression of many of the most powerful neuromodulators, including acetylcholine (ACh), varies tonically and phasically with behavioural state, leading to dynamic, heterogeneous changes in intrinsic neural properties and synaptic connectivity properties. Namely, ACh significantly alters neural firing properties as measured by the phase response curve in a manner that has been shown to alter the propensity for network synchronization. The aim of this simulation study was to build an understanding of how heterogeneity in cholinergic modulation of neural firing properties and heterogeneity in synaptic connectivity affect the initiation and maintenance of synchronous network bursting in excitatory networks. We show that cells that display different levels of ACh modulation have differential roles in generating network activity: weakly modulated cells are necessary for burst initiation and provide synchronizing drive to the rest of the network, whereas strongly modulated cells provide the overall activity level necessary to sustain burst firing. By applying several quantitative measures of network activity, we further show that the existence of network bursting and its characteristics, such as burst duration and intraburst synchrony, are dependent on the fraction of cell types providing the synaptic connections in the network. These results suggest mechanisms underlying ACh modulation of brain oscillations and the modulation of seizure activity during sleep states.

  9. X-ray bursts observed with JEM-X

    DEFF Research Database (Denmark)

    Brandt, Søren Kristian; Chenevez, Jérôme; Lund, Niels;

    2006-01-01

    We report on the search for X-ray bursts in the JEM-X X-ray monitor on INTEGRAL during the first two years of operations. More than 350 bursts from 25 different type-I X-ray burst sources were found.......We report on the search for X-ray bursts in the JEM-X X-ray monitor on INTEGRAL during the first two years of operations. More than 350 bursts from 25 different type-I X-ray burst sources were found....

  10. On the bursting of gene products

    CERN Document Server

    Yvinec, Romain

    2011-01-01

    In this article we demonstrate that the so-called bursting production of molecular species during gene expression may be an artifact caused by low time resolution in experimental data collection and not an actual burst in production. We reach this conclusion through an analysis of a two-stage and binary model for gene expression, and demonstrate that in the limit when mRNA degradation is much faster than protein degradation they are equivalent. The negative binomial distribution is shown to be a limiting case of the binary model for fast "on to off" state transitions and high values of the ratio between protein synthesis and degradation rates. The gene products population increases by unity but multiple times in a time interval orders of magnitude smaller than protein half-life or the precision of the experimental apparatus employed in its detection. This rare-and-fast one-by-one protein synthesis has been interpreted as bursting.

  11. Study on fault induced rock bursts

    Institute of Scientific and Technical Information of China (English)

    LI Zhi-hua; DOU Lin-ming; LU Cai-ping; MU Zong-long; CAO An-ye

    2008-01-01

    In order to study the rules of rock bursts caused by faults by means of mechanical analysis of a roof rock-mass balanced structure and numerical simulation about fault slip destabilization, the effect of coal mining operation on fault plane stresses and slip displacement were studied. The results indicate that the slip displacement sharply increases due to the decrease of normal stress and the increase of shear stress at the fault plane when the working face advances from the footwall to the fault itself, which may induce a fault rock burst. However, this slip displacement will be very small due to the increase of normal stress and the decrease of shear stress when the working face advances from the hanging wall to the fault itself, which results in a very small risk of a fault rock burst.

  12. A mechanism for fast radio bursts

    CERN Document Server

    Romero, Gustavo E; Vieyro, Florencia L

    2015-01-01

    Fast radio bursts are mysterious transient sources likely located at cosmological distances. The derived brightness temperatures exceed by many orders of magnitude the self-absorption limit of incoherent synchrotron radiation, implying the operation of a coherent emission process. We propose a radiation mechanism for fast radio bursts where the emission arises from collisionless Bremsstrahlung in strong plasma turbulence excited by relativistic electron beams. We discuss possible astrophysical scenarios in which this process might operate. The emitting region is a turbulent plasma hit by a relativistic jet, where Langmuir plasma waves produce a concentration of intense electrostatic soliton-like regions (cavitons). The resulting radiation is coherent and, under some physical conditions, can be polarised and have a power-law distribution in energy. We obtain radio luminosities in agreement with the inferred values for fast radio bursts. The timescale of the radio flare in some cases can be extremely fast, of t...

  13. Arc burst pattern analysis fault detection system

    Science.gov (United States)

    Russell, B. Don (Inventor); Aucoin, B. Michael (Inventor); Benner, Carl L. (Inventor)

    1997-01-01

    A method and apparatus are provided for detecting an arcing fault on a power line carrying a load current. Parameters indicative of power flow and possible fault events on the line, such as voltage and load current, are monitored and analyzed for an arc burst pattern exhibited by arcing faults in a power system. These arcing faults are detected by identifying bursts of each half-cycle of the fundamental current. Bursts occurring at or near a voltage peak indicate arcing on that phase. Once a faulted phase line is identified, a comparison of the current and voltage reveals whether the fault is located in a downstream direction of power flow toward customers, or upstream toward a generation station. If the fault is located downstream, the line is de-energized, and if located upstream, the line may remain energized to prevent unnecessary power outages.

  14. Bursting activity spreading through asymmetric interactions

    CERN Document Server

    Onaga, Tomokatsu

    2014-01-01

    People communicate with those who have the same background or share a common interest by using a social networking service (SNS). News or messages propagate through inhomogeneous connections in an SNS by sharing or facilitating additional comments. Such human activity is known to lead to endogenous bursting in the rate of message occurrences. We analyze a multi-dimensional self-exciting process to reveal dependence of the bursting activity on the topology of connections and the distribution of interaction strength on the connections. We determine the critical conditions for the cases where interaction strength is regulated at either the point of input or output for each person. In the input regulation condition, the network may exhibit bursting with infinitesimal interaction strength, if the dispersion of the degrees diverges as in the scale-free networks. In contrast, in the output regulation condition, the critical value of interaction strength, represented by the average number of events added by a single ...

  15. Gamma-Ray Bursts: A Radio Perspective

    Directory of Open Access Journals (Sweden)

    Poonam Chandra

    2016-01-01

    Full Text Available Gamma-ray bursts (GRBs are extremely energetic events at cosmological distances. They provide unique laboratory to investigate fundamental physical processes under extreme conditions. Due to extreme luminosities, GRBs are detectable at very high redshifts and potential tracers of cosmic star formation rate at early epoch. While the launch of Swift and Fermi has increased our understanding of GRBs tremendously, many new questions have opened up. Radio observations of GRBs uniquely probe the energetics and environments of the explosion. However, currently only 30% of the bursts are detected in radio bands. Radio observations with upcoming sensitive telescopes will potentially increase the sample size significantly and allow one to follow the individual bursts for a much longer duration and be able to answer some of the important issues related to true calorimetry, reverse shock emission, and environments around the massive stars exploding as GRBs in the early Universe.

  16. Variable protostellar accretion with episodic bursts

    CERN Document Server

    Vorobyov, Eduard I

    2015-01-01

    We present the latest development of the disk gravitational instability and fragmentation model, originally introduced by us to explain episodic accretion bursts in the early stages of star formation. Using our numerical hydrodynamics model with improved disk thermal balance and star-disk interaction, we computed the evolution of protostellar disks formed from the gravitational collapse of prestellar cores. In agreement with our previous studies, we find that cores of higher initial mass and angular momentum produce disks that are more favorable to gravitational instability and fragmentation, while a higher background irradiation and magnetic fields moderate the disk tendency to fragment. The protostellar accretion in our models is time-variable, thanks to the nonlinear interaction between different spiral modes in the gravitationally unstable disk, and can undergo episodic bursts when fragments migrate onto the star owing to the gravitational interaction with other fragments or spiral arms. Most bursts occur...

  17. Gravitational wave burst search in the Virgo C7 data

    Energy Technology Data Exchange (ETDEWEB)

    Acernese, F; Barone, F [INFN, sezione di Napoli, Universita di Salerno, Fisciano, I-84084 Salerno (Italy); Alshourbagy, M; Barsotti, L; Bigotta, S; Bonelli, L [INFN, Sezione di Pisa, Universita di Pisa, I-56127 Pisa (Italy); Antonucci, F; Astone, P [INFN, Sezione di Roma, I-00185 Roma (Italy); Aoudia, S; Birindelli, S; Bondu, F [Departement Artemis, Observatoire de la Cote d' Azur, CNRS, F-06304 Nice (France); Arun, K G; Bizouard, M-A [LAL, Universite Paris-Sud, IN2P3/CNRS, F-91898 Orsay (France); Ballardin, G [European Gravitational Observatory (EGO), I-56021 Cascina (Pi) (Italy); Barsuglia, M [AstroParticule et Cosmologie (APC), CNRS: UMR7164-IN2P3-Observatoire de Paris-Universite Denis Diderot-Paris VII-CEA : DSM/IRFU (France); Bauer, Th. S [National institute for subatomic physics, NL-1009 DB (Netherlands); Boccara, C [ESPCI, CNRS, F-75005 Paris (France); Braccini, S; Bradaschia, C [INFN, Sezione di Pisa, I-56127 Pisa (Italy); Bosi, L

    2009-04-21

    A search for gravitational wave burst events has been performed with the Virgo C7 commissioning run data that have been acquired in September 2005 over 5 days. It focused on unmodeled short duration signals in the frequency range 150 Hz to 2 kHz. A search aimed at detecting the GW emission from the merger and ring-down phases of binary black hole coalescences was also carried out. An extensive understanding of the data was required to be able to handle a burst search using the output of only one detector. A 90% confidence level upper limit on the number of expected events given the Virgo C7 sensitivity curve has been derived as a function of the signal strength, for unmodeled gravitational wave searches. The sensitivity of the analysis presented is, in terms of the root sum square strain amplitude, h{sub rss} approx = 10{sup -20} Hz{sup -1/2}. This can be interpreted in terms of a frequentist upper limit on the rate R{sub 90%} of detectable gravitational wave bursts at the level of 1.1 events per day at a 90% confidence level. From the binary black hole search, we obtained the distance reach at 50% and 90% efficiency as a function of the total mass of the final black hole. The maximal detection distance for non-spinning high and equal mass black hole binary system obtained by this analysis in C7 data is approx =2.9 +- 0.1 Mpc for a detection efficiency of 50% for a binary of total mass 80 M{sub o-dot}.

  18. Persistent increase of blood lead level and suppression of δ-ALAD activity in northern bobwhite quail orally dosed with even a single 2-mm spent lead shot.

    Science.gov (United States)

    Holladay, S D; Kerr, R; Holladay, J P; Meldrum, B; Williams, S M; Gogal, R M

    2012-10-01

    Birds that display grit ingestion behavior are potentially at risk of lead (Pb) poisoning from mistaken ingestion of spent Pb shot pellets. The majority of available studies designed to assess such risk have used unspent shot pellets rather than field-obtained spent shot, which is oxidized and otherwise changed by weathering. Available studies also often administered more or heavier shot pellets to a bird than it might be expected to ingest. The current study dosed northern bobwhite quail (Colinus virginianus) weighing 194.6 ± 23.1 g (female birds) and 199.3 ± 12.2 g (male birds) with one to three spent no. 9 Pb shot collected from a skeet range, with particular interest in the toxicity that may occur from ingestion of a single 2-mm, 50 mg shot. An 8 week post-dosing clinical observation period was employed, over which feed consumption, body weight, blood Pb levels, and a battery of blood physiological parameters were made. Weight loss occurred in the birds, including male birds dosed with one Pb pellet. Erythrocyte delta aminolevulinic acid dehydratase (δ-ALAD) levels were decreased for the duration of the study across exposures and to levels associated with injury in wild bird populations. Decreased ALAD was particularly severe in female birds dosed with one Pb pellet and was still 92 % decreased at 8 weeks after dosing. Together, these results suggest that inadvertent ingestion of a single no. 9 Pb shot pellet can adversely affect the health of northern bobwhite quail.

  19. May axion clusters be sources of fast radio bursts?

    CERN Document Server

    Pshirkov, Maxim S

    2016-01-01

    Fast radio bursts can be caused by some phenomena related to 'new physics'. One of the most prominent candidates of the kind are axion miniclusters which can undergo conversion into photons in magnetospheres of neutron stars. In this short research note this scenario is investigated and important caveats are examined. First, tidal disruption of miniclusters can considerably extend the time span of conversion process, making it impossible to reach necessary $\\mathcal{O}$(ms) level. Second, existing observations at two widely separated frequencies imply that axion-related scenarios can hardly explain entirety of FRBs.

  20. A zero burst loss architecture for star OBS networks

    OpenAIRE

    Mountrouidou, Xenia; Puttasubbappa, Vishwas; Perros, Harry

    2006-01-01

    Performance studies point to the fact that in an OBS network, the link utilization has to be kept very low in order for the burst loss probability to be within an acceptable level. Various congestion control schemes have been proposed, such as the use of converters, fiber delay lines, and deflection routing. However, these schemes do not alleviate this problem. It is our position that in order for OBS to become commercially viable, new schemes have to be devised that will either guarantee zer...

  1. Supernovae and Gamma-Ray Bursts

    Science.gov (United States)

    Livio, Mario; Panagia, Nino; Sahu, Kailash

    2001-07-01

    Participants; Preface; Gamma-ray burst-supernova relation B. Paczynski; Observations of gamma-ray bursts G. Fishman; Fireballs T. Piran; Gamma-ray mechanisms M. Rees; Prompt optical emission from gamma-ray bursts R. Kehoe, C. Akerlof, R. Balsano, S. Barthelmy, J. Bloch, P. Butterworth, D. Casperson, T. Cline, S. Fletcher, F. Frontera, G. Gisler, J. Heise, J. Hills, K. Hurley, B. Lee, S. Marshall, T. McKay, A. Pawl, L. Piro, B. Priedhorsky, J. Szymanski and J. Wren; X-ray afterglows of gamma-ray bursts L. Piro; The first year of optical-IR observations of SN1998bw I. Danziger, T. Augusteijn, J. Brewer, E. Cappellaro, V. Doublier, T. Galama, J. Gonzalez, O. Hainaut, B. Leibundgut, C. Lidman, P. Mazzali, K. Nomoto, F. Patat, J. Spyromilio, M. Turatto, J. Van Paradijs, P. Vreeswijk and J. Walsh; X-ray emission of Supernova 1998bw in the error box of GRB980425 E. Pian; Direct analysis of spectra of type Ic supernovae D. Branch; The interaction of supernovae and gamma-ray bursts with their surroundings R. Chevalier; Magnetars, soft gamma-ray repeaters and gamma-ray bursts A. Harding; Super-luminous supernova remnants Y. -H. Chu, C. -H. Chen and S. -P. Lai; The properties of hypernovae: SNe Ic 1998bw, 1997ef, and SN IIn 1997cy K. Nomoto, P. Mazzali, T. Nakamura, K. Iwanmoto, K. Maeda, T. Suzuki, M. Turatto, I. Danziger and F. Patat; Collapsars, Gamma-Ray Bursts, and Supernovae S. Woosley, A. MacFadyen and A. Heger; Pre-supernova evolution of massive stars N. Panagia and G. Bono; Radio supernovae and GRB 980425 K. Weiler, N. Panagia, R. Sramek, S. Van Dyk, M. Montes and C. Lacey; Models for Ia supernovae and evolutionary effects P. Hoflich and I. Dominguez; Deflagration to detonation A. Khokhlov; Universality in SN Iae and the Phillips relation D. Arnett; Abundances from supernovae F. -K. Thielemann, F. Brachwitz, C. Freiburghaus, S. Rosswog, K. Iwamoto, T. Nakamura, K. Nomoto, H. Umeda, K. Langanke, G. Martinez-Pinedo, D. Dean, W. Hix and M. Strayer; Sne, GRBs, and the

  2. The Integral Burst Alert System (IBAS)

    CERN Document Server

    Mereghetti, S; Borkowski, J J; Walter, R; Pedersen, H

    2003-01-01

    We describe the INTEGRAL Burst Alert System (IBAS): the automatic software for the rapid distribution of the coordinates of the Gamma-Ray Bursts detected by INTEGRAL. IBAS is implemented as a ground based system, working on the near-real time telemetry stream. During the first six months of operations, six GRB have been detected in the field of view of the INTEGRAL instruments and localized by IBAS. Positions with an accuracy of a few arcminutes are currently distributed by IBAS to the community for follow-up observations within a few tens of seconds of the event.

  3. Gamma-Ray Burst Early Afterglows

    CERN Document Server

    Zhang, B

    2005-01-01

    The successful launch and operation of NASA's Swift Gamma-Ray Burst Explorer open a new era for the multi-wavelength study of the very early afterglow phase of gamma-ray bursts (GRBs). GRB early afterglow information is essential to explore the unknown physical composition of GRB jets, the link between the prompt gamma-ray emission and the afterglow emission, the GRB central engine activity, as well as the immediate GRB environment. Here I review some of the recent theoretical efforts to address these problems and describe how the latest Swift data give answers to these outstanding questions.

  4. Distribution of whistler mode bursts at Venus

    Science.gov (United States)

    Scarf, F. L.; Jordan, K. F.; Russell, C. T.

    1987-01-01

    Several thousand impulsive whistler mode noise bursts were detected by the Pioneer Venus wave instrument during the first 10 seasons with nightside traversals at low altitudes. The altitude distribution for these events shows that essentially all of the bursts were detected when the orbiter was less than 2000 km above the planet, suggesting that the varying plasma conditions could not maintain coherent whistler mode field-aligned guidance over greater distances. Within the 2000-km range, the distribution of the number of events versus altitude shows that there are two distinct subregions. These results are interpreted in terms of two types of whistler mode propagation from sources below the ionosphere.

  5. A Burst Chasing X-ray Polarimeter

    Science.gov (United States)

    Hill, Joanne

    2007-01-01

    This viewgraph presentation reviews the rationale, design, and importance of an X-Ray Polarimeter. There is a brief discussion of Gamma Ray Bursts, followed by a review of the theories of Gamma-Ray Bursts Polarization. This leads to the question of "How do we measure the polarization?" and a discussion of the GRB x-ray emission, the photoelectric effect and photoelectric polarimetry. The requirements for the work, can only be approached using a gas detector. This leads to a discussion of a Micropattern Gas Polarimeter, and the Time-Projection Chamber (TPC) X-ray Polarimeter.

  6. Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic.

    Directory of Open Access Journals (Sweden)

    Andrew N Phillips

    Full Text Available BACKGROUND: There is interest in expanding ART to prevent HIV transmission, but in the group with the highest levels of ART use, men-who-have-sex-with-men (MSM, numbers of new infections diagnosed each year have not decreased as ARTcoverage has increased for reasons which remain unclear. METHODS: We analysed data on the HIV-epidemic in MSM in the UK from a range of sources using an individual-based simulation model. Model runs using parameter sets found to result in good model fit were used to infer changes in HIV-incidence and risk behaviour. RESULTS: HIV-incidence has increased (estimated mean incidence 0.30/100 person-years 1990-1997, 0.45/100 py 1998-2010, associated with a modest (26% rise in condomless sex. We also explored counter-factual scenarios: had ART not been introduced, but the rise in condomless sex had still occurred, then incidence 2006-2010 was 68% higher; a policy of ART initiation in all diagnosed with HIV from 2001 resulted in 32% lower incidence; had levels of HIV testing been higher (68% tested/year instead of 25% incidence was 25% lower; a combination of higher testing and ART at diagnosis resulted in 62% lower incidence; cessation of all condom use in 2000 resulted in a 424% increase in incidence. In 2010, we estimate that undiagnosed men, the majority in primary infection, accounted for 82% of new infections. CONCLUSION: A rise in HIV-incidence has occurred in MSM in the UK despite an only modest increase in levels of condomless sex and high coverage of ART. ART has almost certainly exerted a limiting effect on incidence. Much higher rates of HIV testing combined with initiation of ART at diagnosis would be likely to lead to substantial reductions in HIV incidence. Increased condom use should be promoted to avoid the erosion of the benefits of ART and to prevent other serious sexually transmitted infections.

  7. Suppression of Serum Prolactin Levels after Sports Concussion with Prompt Resolution Upon Independent Clinical Assessment To Permit Return-to-Play.

    Science.gov (United States)

    La Fountaine, Michael F; Toda, Michita; Testa, Anthony; Bauman, William A

    2016-05-01

    A significant outflow of neurotransmitters and metabolites with associated enhanced cortical excitation occurs after concussive head trauma. Cellular changes in the acute post-injury period cannot be observed directly in humans, and as such, require indirect evidence from systems sufficiently sensitive to central neuronal cellular excitation. Dopamine is a neurotransmitter with numerous targets in the central and peripheral nervous system. Changes to central dopaminergic tone result in reciprocal responses to the level of serum prolactin (PRL). Thus, a concussion may lead to abnormal dopaminergic tone, resulting in dynamic perturbations in the serum PRL concentration. To determine the effect of concussion on serum PRL concentrations, venipuncture was performed in the morning in four male intercollegiate athletes (age, 20 ± 1 years; height, 71 ± 5 inches; weight, 174 ± 21 pounds) within 48 h of concussion and again at 7 and 14 days post-injury. Serum PRL concentrations for each visit were categorized by quartile within the normal range. In all athletes, serum PRL concentrations increased from the lower quartiles in samples obtained closer to the time of injury to the higher quartiles at 14 days post-injury. These serum PRL changes accompanied the resolution of symptoms and the clinical decision to permit return-to-play. It may be postulated that transient augmentation of central dopaminergic tone resulted in inhibition of PRL secretion early after concussion and that disinhibition of PRL release occurred when central dopaminergic tone subsequently returned to baseline levels. This novel observation provides evidence for dopaminergic dysfunction after concussion that may be tracked by determination of serum PRL levels.

  8. Growth hormone suppression test

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003376.htm Growth hormone suppression test To use the sharing features on this page, please enable JavaScript. The growth hormone suppression test determines whether growth hormone production is ...

  9. Dexamethasone suppression test

    Science.gov (United States)

    DST; ACTH suppression test; Cortisol suppression test ... During this test, you will receive dexamethasone. This is a strong man-made (synthetic) glucocorticoid medication. Afterward, your blood is drawn ...

  10. Use of water-Cherenkov detectors to detect Gamma Ray Bursts at the Large Aperture GRB Observatory (LAGO)

    Energy Technology Data Exchange (ETDEWEB)

    Allard, D. [APC, CNRS et Universite Paris 7 (France); Allekotte, I. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Alvarez, C. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Asorey, H. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Barros, H. [Laboratorio de Fisica Nuclear, Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of); Bertou, X. [Centro Atomico Bariloche, Instituto Balseiro (Argentina)], E-mail: bertou@cab.cnea.gov.ar; Burgoa, O. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Gomez Berisso, M. [Centro Atomico Bariloche, Instituto Balseiro (Argentina); Martinez, O. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Miranda Loza, P. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Murrieta, T.; Perez, G. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Rivera, H. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Rovero, A. [Instituto de Astronomia y Fisica del Espacio (Argentina); Saavedra, O. [Dipartimento di Fisica Generale and INFN, Torino (Italy); Salazar, H. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Tello, J.C. [Laboratorio de Fisica Nuclear, Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of); Ticona Peralda, R.; Velarde, A. [Instituto de Investigaciones Fisicas, UMSA (Bolivia); Villasenor, L. [Facultad de Ciencias Fisico-Matematicas de la BUAP (Mexico); Instituto de Fisica y Matematicas, Universidad de Michoacan (Mexico)

    2008-09-21

    The Large Aperture GRB Observatory (LAGO) project aims at the detection of high energy photons from Gamma Ray Bursts (GRB) using the single particle technique in ground-based water-Cherenkov detectors (WCD). To reach a reasonable sensitivity, high altitude mountain sites have been selected in Mexico (Sierra Negra, 4550 m a.s.l.), Bolivia (Chacaltaya, 5300 m a.s.l.) and Venezuela (Merida, 4765 m a.s.l.). We report on detector calibration and operation at high altitude, search for bursts in 4 months of preliminary data, as well as search for signal at ground level when satellites report a burst.

  11. Powerful Radio Burst Indicates New Astronomical Phenomenon

    Science.gov (United States)

    2007-09-01

    Astronomers studying archival data from an Australian radio telescope have discovered a powerful, short-lived burst of radio waves that they say indicates an entirely new type of astronomical phenomenon. Region of Strong Radio Burst Visible-light (negative greyscale) and radio (contours) image of Small Magellanic Cloud and area where burst originated. CREDIT: Lorimer et al., NRAO/AUI/NSF Click on image for high-resolution file ( 114 KB) "This burst appears to have originated from the distant Universe and may have been produced by an exotic event such as the collision of two neutron stars or the death throes of an evaporating black hole," said Duncan Lorimer, Assistant Professor of Physics at West Virginia University (WVU) and the National Radio Astronomy Observatory (NRAO). The research team led by Lorimer consists of Matthew Bailes of Swinburne University in Australia, Maura McLaughlin of WVU and NRAO, David Narkevic of WVU, and Fronefield Crawford of Franklin and Marshall College in Lancaster, Pennsylvania. The astronomers announced their findings in the September 27 issue of the online journal Science Express. The startling discovery came as WVU undergraduate student David Narkevic re-analyzed data from observations of the Small Magellanic Cloud made by the 210-foot Parkes radio telescope in Australia. The data came from a survey of the Magellanic Clouds that included 480 hours of observations. "This survey had sought to discover new pulsars, and the data already had been searched for the type of pulsating signals they produce," Lorimer said. "We re-examined the data, looking for bursts that, unlike the usual ones from pulsars, are not periodic," he added. The survey had covered the Magellanic Clouds, a pair of small galaxies in orbit around our own Milky Way Galaxy. Some 200,000 light-years from Earth, the Magellanic Clouds are prominent features in the Southern sky. Ironically, the new discovery is not part of these galaxies, but rather is much more distant

  12. Suppression subtractive hybridization.

    Science.gov (United States)

    Ghorbel, Mohamed T; Murphy, David

    2011-01-01

    Comparing two RNA populations that differ from the effects of a single independent variable, such as a drug treatment or a specific genetic defect, can establish differences in the abundance of specific transcripts that vary in a population dependent manner. There are different methods for identifying differentially expressed genes. These methods include microarray, Serial Analysis of Gene Expression (SAGE), and quantitative Reverse-Transcriptase Polymerase Chain Reaction (qRT-PCR). Herein, the protocol describes an easy and cost-effective alternative that does not require prior knowledge of the transcriptomes under examination. It is specifically relevant when low levels of RNA starting material are available. This protocol describes the use of Switching Mechanism At RNA Termini Polymerase Chain Reaction (SMART-PCR) to amplify cDNA from small amounts of RNA. The amplified cDNA populations under comparison are then subjected to Suppression Subtractive Hybridization (SSH-PCR). SSH-PCR is a technique that couples subtractive hybridization with suppression PCR to selectively amplify fragments of differentially expressed genes. The resulting products are cDNA populations enriched for significantly overrepresented transcripts in either of the two input RNAs. These cDNA populations can then be cloned to generate subtracted cDNA library. Microarrays made with clones from the subtracted forward and reverse cDNA libraries are then screened for differentially expressed genes using targets generated from tester and driver total RNAs.

  13. THE FIVE YEAR FERMI/GBM MAGNETAR BURST CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Collazzi, A. C. [SciTec, Inc., 100 Wall Street, Princeton, NJ 08540 (United States); Kouveliotou, C.; Horst, A. J. van der; Younes, G. A. [Department of Physics, The George Washington University, 725 21st Street NW, Washington, DC 20052 (United States); Kaneko, Y.; Göğüş, E. [Sabancı University, Orhanlı-Tuzla, İstanbul 34956 (Turkey); Lin, L. [François Arago Centre, APC, 10 rue Alice Domon et Léonie Duquet, F-75205 Paris (France); Granot, J. [Department of Natural Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Raanana 43537 (Israel); Finger, M. H. [Universities Space Research Association, NSSTC, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Chaplin, V. L. [School of Medicine, Vanderbilt University, 1161 21st Avenue S, Nashville, TN 37232 (United States); Huppenkothen, D. [Center for Data Science, New York University, 726 Broadway, 7th Floor, New York, NY 10003 (United States); Watts, A. L. [Anton Pannekoek Institute, University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Kienlin, A. von [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching (Germany); Baring, M. G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Gruber, D. [Planetarium Südtirol, Gummer 5, I-39053 Karneid (Italy); Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Drive, Huntsville, AL 35899 (United States); Gibby, M. H., E-mail: acollazzi@scitec.com [Jacobs Technology, Inc., Huntsville, AL (United States); and others

    2015-05-15

    Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550–5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

  14. Power Enhancement Cavity for Burst-Mode Laser Pulses

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yun [ORNL

    2015-01-01

    We demonstrate a novel optical cavity scheme and locking method that can realize the power enhancement of picosecond UV laser pulses operating at a burst mode with arbitrary burst (macropulse) lengths and repetition rates.

  15. Gamma-ray bursts at high redshift

    NARCIS (Netherlands)

    R.A.M.J. Wijers

    1999-01-01

    Gamma-ray bursts are much brighter than supernovae, and could therefore possibly probe the Universe to high redshift. The presently established GRB redshifts range from 0.83 to 5, and quite possibly even beyond that. Since most proposed mechanisms for GRB link them closely to deaths of massive stars

  16. Fast Radio Bursts: Searches, Sensitivities & Implications

    CERN Document Server

    Keane, E F

    2016-01-01

    Fast radio bursts (FRBs) are millisecond-duration transient signals discovered over the past decade. Here we describe the scientific usefulness of FRBs, consider ongoing work at the Parkes telescope, and examine some relevant search sensitivity and completeness considerations. We also look ahead to the results from ongoing and future planned studies in the field.

  17. IPN localizations of Konus short gamma-ray bursts

    CERN Document Server

    Pal'shin, V D; Svinkin, D S; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Mazets, E P; Oleynik, P P; Ulanov, M V; Cline, T; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Trombka, J; McClanahan, T; Starr, R; Goldsten, J; Gold, R; Rau, A; von Kienlin, A; Savchenko, V; Smith, D M; Hajdas, W; Barthelmy, S D; Cummings, J; Gehrels, N; Krimm, H; Palmer, D; Yamaoka, K; Ohno, M; Fukazawa, Y; Hanabata, Y; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Briggs, M S; Kippen, R M; Kouveliotou, C; Meegan, C; Fishman, G; Connaughton, V; Boer, M; Guidorzi, C; Frontera, F; Montanari, E; Rossi, F; Feroci, M; Amati, L; Nicastro, L; Orlandini, M; Monte, Del; Costa, E; Donnarumma, I; Evangelista, Y; Lapshov, I; Lazzarotto, F; Pacciani, L; Rapisarda, M; Soffitta, P; Di Cocco, G; Fuschino, F; Galli, M; Labanti, C; Marisaldi, M; Atteia, J -L; Vanderspek, R; Ricker, G

    2013-01-01

    Between the launch of the GGS Wind spacecraft in 1994 November and the end of 2010, the Konus-Wind experiment detected 314 short-duration gamma-ray bursts (including 24 bursts which can be classified as short bursts with extended emission). During this period, the IPN consisted of up to eleven spacecraft, and using triangulation, the localizations of 276 bursts were obtained. We present the IPN localization data on these events.

  18. BurstMem: A High-Performance Burst Buffer System for Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Teng [Auburn University, Auburn, Alabama; Oral, H Sarp [ORNL; Wang, Yandong [Auburn University, Auburn, Alabama; Settlemyer, Bradley W [ORNL; Atchley, Scott [ORNL; Yu, Weikuan [Auburn University, Auburn, Alabama

    2014-01-01

    The growth of computing power on large-scale sys- tems requires commensurate high-bandwidth I/O system. Many parallel file systems are designed to provide fast sustainable I/O in response to applications soaring requirements. To meet this need, a novel system is imperative to temporarily buffer the bursty I/O and gradually flush datasets to long-term parallel file systems. In this paper, we introduce the design of BurstMem, a high- performance burst buffer system. BurstMem provides a storage framework with efficient storage and communication manage- ment strategies. Our experiments demonstrate that BurstMem is able to speed up the I/O performance of scientific applications by up to 8.5 on leadership computer systems.

  19. NOVEL BIPHASE CODE -INTEGRATED SIDELOBE SUPPRESSION CODE

    Institute of Scientific and Technical Information of China (English)

    Wang Feixue; Ou Gang; Zhuang Zhaowen

    2004-01-01

    A kind of novel binary phase code named sidelobe suppression code is proposed in this paper. It is defined to be the code whose corresponding optimal sidelobe suppression filter outputs the minimum sidelobes. It is shown that there do exist sidelobe suppression codes better than the conventional optimal codes-Barker codes. For example, the sidelobe suppression code of length 11 with filter of length 39 has better sidelobe level up to 17dB than that of Barker code with the same code length and filter length.

  20. Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-κB activity.

    Science.gov (United States)

    Wu, Jyun-Yi; Chen, Chia-Hsin; Wang, Chau-Zen; Ho, Mei-Ling; Yeh, Ming-Long; Wang, Yan-Hsiung

    2013-01-01

    Mesenchymal stem cell (MSC)-based tissue regeneration is a promising therapeutic strategy for treating damaged tissues. However, the inflammatory microenvironment that exists at a local injury site might restrict reconstruction. Low-power laser irradiation (LPLI) has been widely applied to retard the inflammatory reaction. The purpose of this study was to investigate the anti-inflammatory effect of LPLI on human adipose-derived stem cells (hADSCs) in an inflammatory environment. We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2, TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines (Cyclooxygenase-2 (Cox-2), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8)). LPLI markedly inhibited LPS-induced, pro-inflammatory cytokine expression at an optimal dose of 8 J/cm². The inhibitory effect triggered by LPLI might occur through an increase in the intracellular level of cyclic AMP (cAMP), which acts to down-regulate nuclear factor kappa B (NF-κB) transcriptional activity. These data collectively provide insight for further investigations of the potential application of anti-inflammatory treatment followed by stem cell therapy.

  1. Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-κB activity.

    Directory of Open Access Journals (Sweden)

    Jyun-Yi Wu

    Full Text Available Mesenchymal stem cell (MSC-based tissue regeneration is a promising therapeutic strategy for treating damaged tissues. However, the inflammatory microenvironment that exists at a local injury site might restrict reconstruction. Low-power laser irradiation (LPLI has been widely applied to retard the inflammatory reaction. The purpose of this study was to investigate the anti-inflammatory effect of LPLI on human adipose-derived stem cells (hADSCs in an inflammatory environment. We showed that the hADSCs expressed Toll-like Receptors (TLR 1, TLR2, TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS significantly induced the production of pro-inflammatory cytokines (Cyclooxygenase-2 (Cox-2, Interleukin-1β (IL-1β, Interleukin-6 (IL-6, and Interleukin-8 (IL-8. LPLI markedly inhibited LPS-induced, pro-inflammatory cytokine expression at an optimal dose of 8 J/cm². The inhibitory effect triggered by LPLI might occur through an increase in the intracellular level of cyclic AMP (cAMP, which acts to down-regulate nuclear factor kappa B (NF-κB transcriptional activity. These data collectively provide insight for further investigations of the potential application of anti-inflammatory treatment followed by stem cell therapy.

  2. Detecting Pipe Bursts Using Heuristic and CUSUM Methods

    NARCIS (Netherlands)

    Bakker, M.; Jung, D.; Vreeburg, J.; Van de Roer, M.; Lansey, K.; Rierveld, L.

    2014-01-01

    Pipe bursts in a drinking water distribution system lead to water losses, interruption of supply, and damage to streets and houses due to the uncontrolled water flow. To minimize the negative consequences of pipe bursts, an early detection is necessary. This paper describes a heuristic burst detecti

  3. Investigation of Primordial Black Hole Bursts using Interplanetary Network Gamma-ray Bursts

    CERN Document Server

    Ukwatta, T N; MacGibbon, J H; Svinkin, D S; Aptekar, R L; Golenetskii, S V; Frederiks, D D; Pal'shin, V D; Goldsten, J; Boynton, W; Fellows, C; Harshman, K; Mitrofanov, I G; Golovin, D V; Kozyrev, A S; Litvak, M L; Sanin, A B; Rau, A; Kienlin, A; Zhang, X; Briggs, M S; Connaughton, V; Meegan, C; Yamaoka, K; Fukazawa, Y; Ohno, M; Ohmori, N; Takahashi, T; Tashiro, M; Terada, Y; Murakami, T; Makishima, K; Feroci, M; Frontera, F; Guidorzi, C; Barthelmy, S; Cline, T; Gehrels, N; Cummings, J; Krimm, H A; Smith, D M; McTiernan, J

    2015-01-01

    The detection of a gamma-ray burst (GRB) in the solar neighborhood would have very important implications for GRB phenomenology. The leading theories for cosmological GRBs would not be able to explain such events. The final bursts of evaporating Primordial Black Holes (PBHs), however, would be a natural explanation for local GRBs. We present a novel technique that can constrain the minimum distance to gamma-ray bursts using detections from widely separated spacecraft. We applied this method to constrain distances to a sample of 36 short duration GRBs detected by the Interplanetary Network (IPN) that show observational properties that are expected from PBH evaporations. These bursts have minimum possible distances in the 10^13-10^18 cm (7-10^5 AU) range, consistent with the expected PBH energetics and with a possible origin in the solar neighborhood, although none of the bursts can be unambiguously demonstrated to be local. Assuming these bursts are real PBH events, we estimate for the first time lower limits ...

  4. Doubly-Resonant Fabry-Perot Cavity for Power Enhancement of Burst-Mode Picosecond Ultraviolet Pulses

    Energy Technology Data Exchange (ETDEWEB)

    Abudureyimu, Reheman [ORNL; Huang, Chunning [ORNL; Liu, Yun [ORNL

    2015-01-01

    We report on a first experimental demonstration of locking a doubly-resonant Fabry-Perot cavity to burst-mode picosecond ultraviolet (UV) pulses by using a temperature controlled dispersion compensation method. This technique will eventually enable the intra cavity power enhancement of burst-mode 402.5MHz/50ps UV laser pulses with a MW level peak power required for the laser assisted H- beam stripping experiment at the Spallation Neutron Source.

  5. Relations between Strong High-Frequency Microwave Bursts and Proton Events

    Science.gov (United States)

    Grechnev, Victor V.; Meshalkina, Nataliya S.; Chertok, Ilya M.; Kiselev, Valentin I.

    2013-12-01

    Proceeding from close association between solar eruptions, flares, shock waves, and CMEs, we analyze relations between bursts at 35 GHz recorded with the Nobeyama Radio Polarimeters during 1990-2012, on the one hand, and solar energetic particle (SEP) events, on the other hand. Most west to moderately east solar events with strong bursts at 35 GHz produced near-Earth proton enhancements of J (E > 100 MeV) > 1 pfu. The strongest and hardest of those caused ground-level enhancements. There is a general, although scattered, correspondence between proton enhancements and peak fluxes at 35 GHz, especially pronounced if the 35 GHz flux exceeds 104 sfu and the microwave peak frequency is high. These properties indicate emission from numerous high-energy electrons in very strong magnetic fields suggesting a high rate of energy release in the flare-CME formation process. Flaring above the sunspot umbrae appears to be typical of such events. Irrespective of the origin of SEPs, these circumstances demonstrate significant diagnostic potential of high-frequency microwave bursts and sunspot-associated flares for space weather forecasting. Strong prolonged bursts at 35 GHz promptly alert to hazardous SEP events with hard spectra. A few exceptional events with moderate bursts at 35 GHz and strong proton fluxes look challenging, and should be investigated.

  6. Frequency modulation of stochastic gene expression bursts by strongly interacting small RNAs.

    Science.gov (United States)

    Kumar, Niraj; Jia, Tao; Zarringhalam, Kourosh; Kulkarni, Rahul V

    2016-10-01

    The sporadic nature of gene expression at the single-cell level-long periods of inactivity punctuated by bursts of mRNA or protein production-plays a critical role in diverse cellular processes. To elucidate the cellular role of bursting in gene expression, synthetic biology approaches have been used to design simple genetic circuits with bursty mRNA or protein production. Understanding how such genetic circuits can be designed with the ability to control burst-related parameters requires the development of quantitative stochastic models of gene expression. In this work, we analyze stochastic models for the regulation of gene expression bursts by strongly interacting small RNAs. For the parameter range considered, results based on mean-field approaches are significantly inaccurate and alternative analytical approaches are needed. Using simplifying approximations, we obtain analytical results for the corresponding steady-state distributions that are in agreement with results from stochastic simulations. These results indicate that regulation by small RNAs, in the strong interaction limit, can be used to effectively modulate the frequency of bursting. We explore the consequences of such regulation for simple genetic circuits involving feedback effects and switching between promoter states.

  7. A Burst Mode, Ultrahigh Temperature UF4 Vapor Core Reactor Rankine Cycle Space Power System Concept

    Science.gov (United States)

    Dugan, E. T.; Kahook, S. D.; Diaz, N. J.

    1996-01-01

    Static and dynamic neutronic analyses have been performed on an innovative burst mode (100's of MW output for a few thousand seconds) Ulvahigh Temperature Vapor Core Reactor (UTVR) space nuclear power system. The NVTR employs multiple, neutronically-coupled fissioning cores and operates on a direct, closed Rankine cycle using a disk Magnetohydrodynamic (MHD) generater for energy conversion. The UTVR includes two types of fissioning core regions: (1) the central Ultrahigh Temperature Vapor Core (UTVC) which contains a vapor mixture of highly enriched UF4 fuel and a metal fluoride working fluid and (2) the UF4 boiler column cores located in the BeO moderator/reflector region. The gaseous nature of the fuel the fact that the fuel is circulating, the multiple coupled fissioning cores, and the use of a two phase fissioning fuel lead to unique static and dynamic neutronic characteristics. Static neutronic analysis was conducted using two-dimensional S sub n, transport theory calculations and three-dimensional Monte Carlo transport theory calculations. Circulating-fuel, coupled-core point reactor kinetics equations were used for analyzing the dynamic behavior of the UTVR. In addition to including reactivity feedback phenomena associated with the individual fissioning cores, the effects of core-to-core neutronic and mass flow coupling between the UTVC and the surrounding boiler cores were also included in the dynamic model The dynamic analysis of the UTVR reveals the existence of some very effectlve inherent reactivity feedback effects that are capable of quickly stabilizing this system, within a few seconds, even when large positive reactivity insertions are imposed. If the UTVC vapor fuel density feedback is suppressed, the UTVR is still inherently stable because of the boiler core liquid-fuel volume feedback; in contrast, suppression of the vapor fuel density feedback in 'conventional" gas core cavity reactors causes them to become inherently unstable. Due to the

  8. INTERPLANETARY NETWORK LOCALIZATIONS OF KONUS SHORT GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Pal' shin, V. D.; Svinkin, D. S.; Aptekar, R. L.; Golenetskii, S. V.; Frederiks, D. D.; Mazets, E. P.; Oleynik, P. P.; Ulanov, M. V. [Ioffe Physical Technical Institute, St. Petersburg, 194021 (Russian Federation); Hurley, K. [Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720-7450 (United States); Cline, T.; Trombka, J.; McClanahan, T. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Mitrofanov, I. G.; Golovin, D. V.; Kozyrev, A. S.; Litvak, M. L.; Sanin, A. B. [Space Research Institute, 84/32, Profsoyuznaya, Moscow 117997 (Russian Federation); Boynton, W.; Fellows, C.; Harshman, K., E-mail: val@mail.ioffe.ru [Department of Planetary Sciences, University of Arizona, Tucson, AZ 85721 (United States); and others

    2013-08-15

    Between the launch of the Global Geospace Science Wind spacecraft in 1994 November and the end of 2010, the Konus-Wind experiment detected 296 short-duration gamma-ray bursts (including 23 bursts which can be classified as short bursts with extended emission). During this period, the Interplanetary Network (IPN) consisted of up to 11 spacecraft, and using triangulation, the localizations of 271 bursts were obtained. We present the most comprehensive IPN localization data on these events. The short burst detection rate, {approx}18 yr{sup -1}, exceeds that of many individual experiments.

  9. Network and external perturbation induce burst synchronisation in cat cerebral cortex

    Science.gov (United States)

    Lameu, Ewandson L.; Borges, Fernando S.; Borges, Rafael R.; Batista, Antonio M.; Baptista, Murilo S.; Viana, Ricardo L.

    2016-05-01

    The brain of mammals are divided into different cortical areas that are anatomically connected forming larger networks which perform cognitive tasks. The cat cerebral cortex is composed of 65 areas organised into the visual, auditory, somatosensory-motor and frontolimbic cognitive regions. We have built a network of networks, in which networks are connected among themselves according to the connections observed in the cat cortical areas aiming to study how inputs drive the synchronous behaviour in this cat brain-like network. We show that without external perturbations it is possible to observe high level of bursting synchronisation between neurons within almost all areas, except for the auditory area. Bursting synchronisation appears between neurons in the auditory region when an external perturbation is applied in another cognitive area. This is a clear evidence that burst synchronisation and collective behaviour in the brain might be a process mediated by other brain areas under stimulation.

  10. Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae).

    Science.gov (United States)

    Mbaze, Luc Meva'a; Lado, Jean Alexandre; Wansi, Jean Duplex; Shiao, Tze Chieh; Chiozem, David Dako; Mesaik, Muhammad Ahmed; Choudhary, Muhammad Iqbal; Lacaille-Dubois, Marie-Aleth; Wandji, Jean; Roy, René; Sewald, Norbert

    2009-01-01

    Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis. Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells. All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC(50)=2.0-6.5 microM, but no cytotoxic effect was observed (IC(50)>100 microM).

  11. Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils.

    OpenAIRE

    Wang, J. P.; Raung, S L; Hsu, M. F.; Chen, C.C.

    1994-01-01

    1. The possible mechanisms of action of the inhibitory effect of gomisin C on the respiratory burst of rat neutrophils in vitro was investigated. 2. The peptide formyl-Met-Leu-Phe (FMLP) induced superoxide anion (O2-) formation and O2 consumption, which was inhibited by gomisin C in a concentration-dependent manner (IC50 21.5 +/- 4.2 micrograms ml-1 for O2- formation). Gomisin C also suppressed O2- formation and consumption at low concentrations of phorbol myristate acetate (PMA) with an IC50...

  12. Bursting and large-scale intermittency in turbulent convection with differential rotation

    DEFF Research Database (Denmark)

    Garcia, O.E.; Bian, N.H.

    2003-01-01

    The tilting mechanism, which generates differential rotation in two-dimensional turbulent convection, is shown to produce relaxation oscillations in the mean flow energy integral and bursts in the global fluctuation level, akin to Lotka-Volterra oscillations. The basic reason for such behavior...

  13. Phase dependency of long-term potentiation induction during the intermittent bursts of carbachol-induced β oscillation in rat hippocampal slices.

    Science.gov (United States)

    Nishimura, Motoshi; Nakatsuka, Hiroki; Natsume, Kiyohisa

    2012-01-01

    The rodent hippocampus possesses theta (θ) and beta (β) rhythms, which occur intermittently as bursts. Both rhythms are related to spatial memory processing in a novel environment. θ rhythm is related to spatial memory encoding process. β rhythm is related to the match/mismatch process. In the match/mismatch process, rodent hippocampus detects a representation matching sensory inputs of the current place among the retrieved internal representations of places. Long-term synaptic potentiation (LTP) is induced in both processes. The cholinergic agent carbachol induces intermittent θ and β oscillations in in vitro slices similar to in vivo bursts. LTP is facilitated during the generation of θ oscillation, suggesting that the facilitation of LTP is dependent upon the phases of intermittent burst (burst phases) of the oscillation. However, whether this is the case for β oscillation has not yet been studied. In the present study, LTP-inducing θ-burst stimulation was administered at the different burst phases of carbachol-induced β oscillations (CIBO), and the synaptic changes were measured at CA3-CA3 pyramidal cell synapses (CA3 synapse) and at CA3-CA1 pyramidal cell synapses (CA1 synapse). At the CA3 synapse, the largest magnitude of LTP was induced at the late burst phases of CIBO. At the CA1 synapse, LTP was induced only at the late burst phases. Modulation of LTP was suppressed when CIBO was blocked by the application of atropine at both synapses. The results suggest that the bursts of hippocampal β rhythm can determine the optimal temporal period for completing with the match/mismatch process.

  14. hnRNP A2/B1 interacts with influenza A viral protein NS1 and inhibits virus replication potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nuclear export.

    Science.gov (United States)

    Wang, Yimeng; Zhou, Jianhong; Du, Yuchun

    2014-01-20

    The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins. In this study, we identified heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as an interacting partner of NS1 proteins by a proteomic method. Knockdown of hnRNP A2/B1 by small interfering RNA (siRNA) resulted in higher levels of NS vRNA, NS1 mRNA, and NS1 protein in the virus-infected cells. In addition, we demonstrated that hnRNP A2/B1 proteins are associated with NS1 and NS2 mRNAs and that knockdown of hnRNP A2/B1 promotes transport of NS1 mRNA from the nucleus to the cytoplasm in the infected cells. Lastly, we showed that knockdown of hnRNP A2/B1 leads to enhanced virus replication. Our results suggest that hnRNP A2/B1 plays an inhibitory role in the replication of influenza A virus in host cells potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nucleocytoplasmic translocation.

  15. Energy bursts in vibrated shallow granular systems

    Science.gov (United States)

    Rivas, N.; Risso, D.; Soto, R.; Cordero, P.

    2011-03-01

    In a mixture of two species of inelastic spheres of equal size but different mass, placed in a vertically vibrated shallow box (large horizontal dimensions and height comparable to the grains' size), there is spontaneous segregation. Once the system is at least partly segregated energy bursts recurrently take place: the horizontal kinetic energy of the heavy particles, that normally is small, suddenly increases an order of magnitude. An explanation of these events is provided based on the existence of a fixed point for an isolated particle bouncing with only vertical motion between the top and bottom plates. Energy bursts occur when clusters of heavy particles start a chain reaction of collisions that transfer vertical energy to horizontal energy producing an expansion of the cluster.

  16. Bursting behaviours in cascaded stimulated Brillouin scattering

    Institute of Scientific and Technical Information of China (English)

    Liu Zhan-Jun; He Xian-Tu; Zheng Chun-Yang; Wang Yu-Gang

    2012-01-01

    Stimulated Brillouin scattering is studied by numerically solving the Vlasov-Maxwell system.A cascade of stimulated Brillouin scattering can occur when a linearly polarized laser pulse propagates in a plasma.It is found that a stimulated Brillouin scattering cascade can reduce the scattering and increase the transmission of light,as well as introduce a bursting behaviour in the evolution of the laser-plasma interaction.The bursting time in the reflectivity is found to be less than half the ion acoustic period.The ion temperature can affect the stimulated Brillouin scattering cascade,which can repeat several times at low ion temperatures and can be completely eliminated at high ion temperatures.For stimulated Brillouin scattering saturation,higher-harmonic generation and wave-wave interaction of the excited ion acoustic waves can restrict the amplitude of the latter.In addition,stimulated Brillouin scattering cascade can restrict the amplitude of the scattered light.

  17. On associating Fast Radio Bursts with afterglows

    CERN Document Server

    Vedantham, H K; Mooley, K; Frail, D; Hallinan, G; Kulkarni, S R

    2016-01-01

    A radio source that faded over 6 days, with a redshift $z\\approx0.5$ host, has been identified by Keane et al. (2016) as the transient afterglow to a Fast Radio Burst (FRB 150418). We report follow-up radio and optical observations of the afterglow candidate, and find a source that is consistent with an active galactic nucleus (AGN). If the afterglow-candidate is nonetheless a prototypical FRB afterglow, existing surveys limit the fraction of FRBs that produce afterglows to 0.25 for modulation-index $m=\\Delta S/\\bar{S}\\geq0.7$, and 0.07 for $m\\geq1$, at 95\\% confidence. Afterglow associations with the barrage of bursts expected from future FRB surveys must satisfy constraints on the afterglow rate set by state of the art slow-transient surveys.

  18. Burst Detector X-Ray IIR

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The Burst Detector X-Ray (BDX) instrument for the Block IIR series of Global Positioning System satellites is described. The BDX instrument can locate and characterize exoatmospheric nuclear detonations by using four sensors consisting of sets of filters over silicon diodes to detect x rays of various energies from the burst. On the BDX-IIR, a fifth sensor with a response spanning those of the other sensors confirms coincidences among the four main channels. The mechanical and electronic features of the BDX-IIR and its sensors are described. The calibrations and the system tests used in flight are presented. The commands for the BDX-IIR are given. The messages sent from the BDX-IIR are described in detail.

  19. Bursts of activity in collective cell migration

    CERN Document Server

    Chepizhko, Oleksandr; Mastrapasqua, Eleonora; Nourazar, Mehdi; Ascagni, Miriam; Sugni, Michela; Fascio, Umberto; Leggio, Livio; Malinverno, Chiara; Scita, Giorgio; Santucci, Stephane; Alava, Mikko J; Zapperi, Stefano; La Porta, Caterina A M

    2016-01-01

    Dense monolayers of living cells display intriguing relaxation dynamics, reminiscent of soft and glassy materials close to the jamming transition, and migrate collectively when space is available, as in wound healing or in cancer invasion. Here we show that collective cell migration occurs in bursts that are similar to those recorded in the propagation of cracks, fluid fronts in porous media and ferromagnetic domain walls. In analogy with these systems, the distribution of activity bursts displays scaling laws that are universal in different cell types and for cells moving on different substrates. The main features of the invasion dynamics are quantitatively captured by a model of interacting active particles moving in a disordered landscape. Our results illustrate that collective motion of living cells is analogous to the corresponding dynamics in driven, but inanimate, systems.

  20. Stacked search for time shifted high energy neutrinos from gamma ray bursts with the \\ANTARES neutrino telescope

    CERN Document Server

    Adrian-Martínez, S; André, M; Anton, G; Ardid, M; Aubert, J -J; Baret, B; Barrios-Marti, J; Basa, S; Bertin, V; Biagi, S; Bormuth, R; Bouwhuis, M C; Bruijn, R; Brunner, J; Busto, J; Capone, A; Caramete, L; Carr, J; Chiarusi, T; Circella, M; Coniglione, R; Costantini, H; Coyle, P; Creusot, A; Dekeyser, I; Deschamps, A; De Bonis, G; Distefano, C; Donzaud, C; Dornic, D; Drouhin, D; Dumas, A; Eberl, T; Elsasser, D; Enzenhofer, A; Fehn, K; Felis, I; Fermani, P; Folger, F; Fusco, L A; Galatà, S; Gay, P; Geisselsoeder, S; Geyer, K; Giordano, V; Gleixner, A; Gracia-Ruiz, R; Graf, K; Hallmann, S; van Haren, H; Heijboer, A J; Hello, Y; Hernàndez-Rey, J J; Hoessl, J; Hofestadt, J; Hugon, C; James, C W; de Jong, M; Kadler, M; Kadler, M; Kalekin, O; Katz, U; Kiessling, D; Kooijman, P; Kouchner, A; Kreter, M; Kreykenbohm, I; Kulikovskiy, V; Lahmann, R; Lefèvre, D; Leonora, E; Marcelin, M; Margiotta, A; Marinelli, A; Martínez-Mora, J A; Mathieu, A; Michael, T; Migliozzi, P; Moussa, A; Muller, C; Nezri, E; Pavalas, G E; Pellegrino, C; Perrina, C; Piattelli, P; Popa, V; Pradier, T; Racca, C; Riccobene, G; Richter, R; Roensch, K; Saldaña, M; Samtleben, D F E; Sánchez-Losa, A; Sanguineti, M; Sapienza, P; Schmid, J; Schnabel, J; Schussler, F; Seitz, T; Sieger, C; Spurio, M; Steijger, J J M; Stolarczyk, Th; Taiuti, M; Tamburini, C; Trovato, A; Tselengidou, M; Tonnis, C; Vallage, B; Vallée, C; Van Elewyck, V; Visser, E; Vivolo, D; Wagner, S; Wilms, J; Zornoza, J D; Zúñiga, J

    2016-01-01

    A search for high-energy neutrino emission correlated with gamma-ray bursts outside the electromagnetic prompt-emission time window is presented. Using a stacking approach of the time delays between reported gamma-ray burst alerts and spatially coincident muon-neutrino signatures, data from the Antares neutrino telescope recorded between 2007 and 2012 are analysed. One year of public data from the IceCube detector between 2008 and 2009 have been also investigated. The respective timing pro?les are scanned for statistically significant accumulations within 40 days of the Gamma Ray Burst, as expected from Lorentz Invariance Violation effects and some astrophysical models. No significant excess over the expected accidental coincidence rate could be found in either of the two data sets. The average strength of the neutrino signal is found to be fainter than one detectable neutrino signal per hundred gamma-ray bursts in the Antares data at 90% confidence level.

  1. Identifying crucial parameter correlations maintaining bursting activity.

    Directory of Open Access Journals (Sweden)

    Anca Doloc-Mihu

    2014-06-01

    Full Text Available Recent experimental and computational studies suggest that linearly correlated sets of parameters (intrinsic and synaptic properties of neurons allow central pattern-generating networks to produce and maintain their rhythmic activity regardless of changing internal and external conditions. To determine the role of correlated conductances in the robust maintenance of functional bursting activity, we used our existing database of half-center oscillator (HCO model instances of the leech heartbeat CPG. From the database, we identified functional activity groups of burster (isolated neuron and half-center oscillator model instances and realistic subgroups of each that showed burst characteristics (principally period and spike frequency similar to the animal. To find linear correlations among the conductance parameters maintaining functional leech bursting activity, we applied Principal Component Analysis (PCA to each of these four groups. PCA identified a set of three maximal conductances (leak current, [Formula: see text]Leak; a persistent K current, [Formula: see text]K2; and of a persistent Na+ current, [Formula: see text]P that correlate linearly for the two groups of burster instances but not for the HCO groups. Visualizations of HCO instances in a reduced space suggested that there might be non-linear relationships between these parameters for these instances. Experimental studies have shown that period is a key attribute influenced by modulatory inputs and temperature variations in heart interneurons. Thus, we explored the sensitivity of period to changes in maximal conductances of [Formula: see text]Leak, [Formula: see text]K2, and [Formula: see text]P, and we found that for our realistic bursters the effect of these parameters on period could not be assessed because when varied individually bursting activity was not maintained.

  2. GAMMA-RAY BURSTS, NEW COSMOLOGICAL BEACONS

    Directory of Open Access Journals (Sweden)

    V. Avila-Reese

    2009-01-01

    Full Text Available Long Gamma-Ray Bursts (GRBs are the brightest electromagnetic explosions in the Universe, associated to the death of massive stars. As such, GRBs are potential tracers of the evolution of the cosmic massive star formation, metallicity, and Initial Mass Function. GRBs also proved to be appealing cosmological distance indicators. This opens a unique opportunity to constrain the cosmic expansion history up to redshifts 5-6. A brief review on both subjects is presented here.

  3. Short-term Effects of Gamma Ray Bursts on Earth

    CERN Document Server

    Martín, Osmel; Cárdenas, Rolando; Horváth, J E

    2009-01-01

    The aim of the present work is to study the potential short-term atmospheric and biospheric influence of Gamma Ray Bursts on the Earth. We focus in the ultraviolet flash at the planet's surface, which occurs as a result of the retransmission of the $\\gamma$ radiation through the atmosphere. This would be the only important short-term effect on life. We mostly consider Archean and Proterozoic eons, and for completeness we also comment on the Phanerozoic. Therefore, in our study we consider atmospheres with oxygen levels ranging from $10^{-5}$ to 1% of the present atmospheric level, representing different moments in the oxygen rise history. Ecological consequences and some strategies to estimate their importance are outlined.

  4. A Fast Radio Burst Host Galaxy

    CERN Document Server

    Keane, E F; Bhandari, S; Barr, E; Bhat, N D R; Burgay, M; Caleb, M; Flynn, C; Jameson, A; Kramer, M; Petroff, E; Possenti, A; van Straten, W; Bailes, M; Burke-Spolaor, S; Eatough, R P; Stappers, B W; Totani, T; Honma, M; Furusawa, H; Hattori, T; Morokuma, T; Niino, Y; Sugai, H; Terai, T; Tominaga, N; Yamasaki, S; Yasuda, N; Allen, R; Cooke, J; Jencson, J; Kasliwal, M M; Kaplan, D L; Tingay, S J; Williams, A; Wayth, R; Chandra, P; Perrodin, D; Berezina, M; Mickaliger, M; Bassa, C

    2016-01-01

    In recent years, millisecond duration radio signals originating from distant galaxies appear to have been discovered in the so-called Fast Radio Bursts. These signals are dispersed according to a precise physical law and this dispersion is a key observable quantity which, in tandem with a redshift measurement, can be used for fundamental physical investigations. While every fast radio burst has a dispersion measurement, none before now have had a redshift measurement, due to the difficulty in pinpointing their celestial coordinates. Here we present the discovery of a fast radio burst and the identification of a fading radio transient lasting $\\sim 6$ days after the event, which we use to identify the host galaxy; we measure the galaxy's redshift to be $z=0.492\\pm0.008$. The dispersion measure and redshift, in combination, provide a direct measurement of the cosmic density of ionised baryons in the intergalactic medium of $\\Omega_{\\mathrm{IGM}}=4.9 \\pm 1.3\\%$, in agreement with the expectation from WMAP, and i...

  5. Delayed Nickel Decay in Gamma Ray Bursts

    CERN Document Server

    McLaughlin, G C

    2002-01-01

    Recently observed emission lines in the X-ray afterglow of gamma ray bursts suggest that iron group elements are either produced in the gamma ray burst, or are present nearby. If this material is the product of a thermonuclear burn, then such material would be expected to be rich in Nickel-56. If the nickel remains partially ionized, this prevents the electron capture reaction normally associated with the decay of Nickel-56, dramatically increasing the decay timescale. Here we examine the consequences of rapid ejection of a fraction of a solar mass of iron group material from the center of a collapsar/hypernova. The exact rate of decay then depends on the details of the ionization and therefore the ejection process. Future observations of iron, nickel and cobalt lines can be used to diagnose the origin of these elements and to better understand the astrophysical site of gamma ray bursts. In this model, the X-ray lines of these iron-group elements could be detected in suspected hypernovae that did not produce ...

  6. RADIO FLARES FROM GAMMA-RAY BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Kopač, D.; Mundell, C. G.; Kobayashi, S.; Virgili, F. J. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool, L3 5RF (United Kingdom); Harrison, R. [Department of Astrophysics, School of Physics and Astronomy, Tel Aviv University, 69978 Tel Aviv (Israel); Japelj, J.; Gomboc, A. [Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, 1000 Ljubljana (Slovenia); Guidorzi, C. [Department of Physics and Earth Sciences, University of Ferrara, Via Saragat, 1, I-44122 Ferrara (Italy); Melandri, A., E-mail: D.Kopac@ljmu.ac.uk [INAF/Brera Astronomical Observatory, via Bianchi 46, I-23807, Merate (Italy)

    2015-06-20

    We present predictions of centimeter and millimeter radio emission from reverse shocks (RSs) in the early afterglows of gamma-ray bursts (GRBs) with the goal of determining their detectability with current and future radio facilities. Using a range of GRB properties, such as peak optical brightness and time, isotropic equivalent gamma-ray energy, and redshift, we simulate radio light curves in a framework generalized for any circumburst medium structure and including a parameterization of the shell thickness regime that is more realistic than the simple assumption of thick- or thin-shell approximations. Building on earlier work by Mundell et al. and Melandri et al. in which the typical frequency of the RS was suggested to lie at radio rather than optical wavelengths at early times, we show that the brightest and most distinct RS radio signatures are detectable up to 0.1–1 day after the burst, emphasizing the need for rapid radio follow-up. Detection is easier for bursts with later optical peaks, high isotropic energies, lower circumburst medium densities, and at observing frequencies that are less prone to synchrotron self-absorption effects—typically above a few GHz. Given recent detections of polarized prompt gamma-ray and optical RS emission, we suggest that detection of polarized radio/millimeter emission will unambiguously confirm the presence of low-frequency RSs at early time.

  7. Black Hole Accretion in Gamma Ray Bursts

    Directory of Open Access Journals (Sweden)

    Agnieszka Janiuk

    2017-02-01

    Full Text Available We study the structure and evolution of the hyperaccreting disks and outflows in the gamma ray bursts central engines. The torus around a stellar mass black hole is composed of free nucleons, Helium, electron-positron pairs, and is cooled by neutrino emission. Accretion of matter powers the relativistic jets, responsible for the gamma ray prompt emission. The significant number density of neutrons in the disk and outflowing material will cause subsequent formation of heavier nuclei. We study the process of nucleosynthesis and its possible observational consequences. We also apply our scenario to the recent observation of the gravitational wave signal, detected on 14 September 2015 by the two Advanced LIGO detectors, and related to an inspiral and merger of a binary black hole system. A gamma ray burst that could possibly be related with the GW150914 event was observed by the Fermi satellite. It had a duration of about 1 s and appeared about 0.4 s after the gravitational-wave signal. We propose that a collapsing massive star and a black hole in a close binary could lead to the event. The gamma ray burst was powered by a weak neutrino flux produced in the star remnant’s matter. Low spin and kick velocity of the merged black hole are reproduced in our simulations. Coincident gravitational-wave emission originates from the merger of the collapsed core and the companion black hole.

  8. Vibration-induced drop atomization and bursting

    Science.gov (United States)

    James, A. J.; Vukasinovic, B.; Smith, Marc K.; Glezer, A.

    2003-02-01

    A liquid drop placed on a vibrating diaphragm will burst into a fine spray of smaller secondary droplets if it is driven at the proper frequency and amplitude. The process begins when capillary waves appear on the free surface of the drop and then grow in amplitude and complexity as the acceleration amplitude of the diaphragm is slowly increased from zero. When the acceleration of the diaphragm rises above a well-defined critical value, small secondary droplets begin to be ejected from the free-surface wave crests. Then, quite suddenly, the entire volume of the drop is ejected from the vibrating diaphragm in the form of a spray. This event is the result of an interaction between the fluid dynamical process of droplet ejection and the vibrational dynamics of the diaphragm. During droplet ejection, the effective mass of the drop diaphragm system decreases and the resonance frequency of the system increases. If the initial forcing frequency is above the resonance frequency of the system, droplet ejection causes the system to move closer to resonance, which in turn causes more vigorous vibration and faster droplet ejection. This ultimately leads to drop bursting. In this paper, the basic phenomenon of vibration-induced drop atomization and drop bursting will be introduced, demonstrated, and characterized. Experimental results and a simple mathematical model of the process will be presented and used to explain the basic physics of the system.

  9. The CHIME Fast Radio Burst Project

    Science.gov (United States)

    Kaspi, Victoria M.; CHIME/FRB Collaboration

    2017-01-01

    Fast Radio Bursts are a recently discovered phenomenon consisting of short (few ms) bursts of radio waves that have dispersion measures that strongly suggest an extragalactic and possibly cosmological, but yetunknown, origin. The Canadian Hydrogen Intensity Mapping Experiment was designed to study Baryon Acoustic Oscillations through mapping of redshifted hydrogen, in order to constrain the nature of Dark Energy. CHIME, currently under construction in Penticton, BC in Canada, consists of 4 cylindrical paraboloid reflectors having total collecting area 80 m x 100 m, and will be sensitive in the 400-800 MHz band. With 2048 independent feeds hung along the cylinder axes, CHIME is a transit telescope with no moving parts, but is sensitive to the full ~200 sq. degrees overhead in 1024 formed beams, thanks to the largest correlator ever built. Given CHIME's enormous sensitivity, bandwidth and unprecedented field of view for the radio regime, CHIME will be a superb instrument for studying Fast Radio Bursts, with expected detected event rates of several to several dozen per day, hence promising major progress on the origin and nature of FRBs.

  10. Composite-flywheel burst-containment study

    Energy Technology Data Exchange (ETDEWEB)

    Sapowith, A D; Handy, W E

    1982-04-08

    A key component impacting total flywheel energy storage system weight is the containment structure. This report addresses the factors that shape this structure and define its design criteria. In addition, containment weight estimates are made for the several composite flywheel designs of interest so that judgements can be made as to the relative weights of their containment structure. The requirements set down for this program were that all containment weight estimates be based on a 1 kWh burst. It should be noted that typical flywheel requirements for regenerative braking of small automobiles call for deliverable energies of 0.25 kWh. This leads to expected maximum burst energies of 0.5 kWh. The flywheels studied are those considered most likely to be carried further for operational design. These area: The pseudo isotropic disk flywheel, sometimes called the alpha ply; the SMC molded disk; either disk with a carbon ring; the subcircular rim with cruciform hub; and Avco's bi-directional circular weave disk. The flywheel materials for the disk are S-glass; the subcircular rim is Kevlar over S-glass. Test data on flywheel bursts and containment failures were analyzed. Recommendations are made for further testing.

  11. Radio flares from gamma-ray bursts

    CERN Document Server

    Kopac, D; Kobayashi, S; Virgili, F J; Harrison, R; Japelj, J; Guidorzi, C; Melandri, A; Gomboc, A

    2015-01-01

    We present predictions of centimeter and millimeter radio emission from reverse shocks in the early afterglows of gamma-ray bursts with the goal of determining their detectability with current and future radio facilities. Using a range of GRB properties, such as peak optical brightness and time, isotropic equivalent gamma-ray energy and redshift, we simulate radio light curves in a framework generalized for any circumburst medium structure and including a parametrization of the shell thickness regime that is more realistic than the simple assumption of thick- or thin-shell approximations. Building on earlier work by Mundell et al. (2007) and Melandri et al. (2010) in which the typical frequency of the reverse shock was suggested to lie at radio, rather than optical wavelengths at early times, we show that the brightest and most distinct reverse-shock radio signatures are detectable up to 0.1 -- 1 day after the burst, emphasizing the need for rapid radio follow-up. Detection is easier for bursts with later opt...

  12. Automatic Cloud Bursting under FermiCloud

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Hao [Fermilab; Shangping, Ren [IIT; Garzoglio, Gabriele [Fermilab; Timm, Steven [Fermilab; Bernabeu, Gerard [Fermilab; Kim, Hyun Woo; Chadwick, Keith; Jang, Haengjin [KISTI, Daejeon; Noh, Seo-Young [KISTI, Daejeon

    1900-01-01

    Cloud computing is changing the infrastructure upon which scientific computing depends from supercomputers and distributed computing clusters to a more elastic cloud-based structure. The service-oriented focus and elasticity of clouds can not only facilitate technology needs of emerging business but also shorten response time and reduce operational costs of traditional scientific applications. Fermi National Accelerator Laboratory (Fermilab) is currently in the process of building its own private cloud, FermiCloud, which allows the existing grid infrastructure to use dynamically provisioned resources on FermiCloud to accommodate increased but dynamic computation demand from scientists in the domains of High Energy Physics (HEP) and other research areas. Cloud infrastructure also allows to increase a private cloud’s resource capacity through “bursting” by borrowing or renting resources from other community or commercial clouds when needed. This paper introduces a joint project on building a cloud federation to support HEP applications between Fermi National Accelerator Laboratory and Korea Institution of Science and Technology Information, with technical contributions from the Illinois Institute of Technology. In particular, this paper presents two recent accomplishments of the joint project: (a) cloud bursting automation and (b) load balancer. Automatic cloud bursting allows computer resources to be dynamically reconfigured to meet users’ demands. The load balance algorithm which the cloud bursting depends on decides when and where new resources need to be allocated. Our preliminary prototyping and experiments have shown promising success, yet, they also have opened new challenges to be studied

  13. Bursting of a soap film in a viscous environment

    Science.gov (United States)

    Joanny, J.-F.; De Gennes, P. G.

    1987-11-01

    In a dense (polyhedral) O/W emulsion the oil droplets are separated by thin films of water. If at time t = 0, one film is broken locally, it shrinks and the zone of direct contact between the two oil droplets expands, with a growing radius R( t). The analog bursting of a soap films in air was studied long ago by Mysels and coworkers. But the presence of the viscous oil should slow down the process, and suppress the shock wave aspects which are often present in air. We assume first that the surfactant is strictly insoluble in oil and we discuss two regimes: (I) The water film is at the midplane of a slab of oil, bounded by solid walls: then we expect R( t)∼ t{1}/{2} even if non-linearities (due to the Langmuir equation of state of the monolayers) are incorporated. (II) With a very large slab of oil (or with two large oil droplets) we are led to R( t)∼ {3}/{4}. Regime II would be realize in dense emulsions, but regime I is probably more interesting for fundamental studies on the rheology of monolayers. Finally, when the surfactant is slightly soluble in oil, we predict R( t)∼ t{3}/{4} in case I, and R( t)∼ t in case II.

  14. Z-Burst Scenario for the Highest Energy Cosmic Rays

    CERN Document Server

    Fodor, Z; Ringwald, Andreas

    2002-01-01

    The origin of highest energy cosmic rays is yet unknown. An appealing possibility is the so-called Z-burst scenario, in which a large fraction of these cosmic rays are decay products of Z bosons produced in the scattering of ultrahigh energy neutrinos on cosmological relic neutrinos. The comparison between the observed and predicted spectra constrains the mass of the heaviest neutrino. The required neutrino mass is fairly robust against variations of the presently unknown quantities, such as the amount of relic neutrino clustering, the universal photon radio background and the extragalactic magnetic field. Considering different possibilities for the ordinary cosmic rays the required neutrino masses are determined. In the most plausible case that the ordinary cosmic rays are of extragalactic origin and the universal radio background is strong enough to suppress high energy photons, the required neutrino mass is 0.08 eV < m_nu < 0.40 eV. The required ultrahigh energy neutrino flux should be detected in th...

  15. High temperature suppression of dioxins.

    Science.gov (United States)

    Zhan, Ming-Xiu; Chen, Tong; Fu, Jian-Ying; Lin, Xiao-Qing; Lu, Sheng-Yong; Li, Xiao-Dong; Yan, Jian-Hua; Buekens, Alfons

    2016-03-01

    Combined Sulphur-Nitrogen inhibitors, such as sewage sludge decomposition gases (SDG), thiourea and amidosulphonic acid have been observed to suppress the de novo synthesis of dioxins effectively. In this study, the inhibition of PCDD/Fs formation from model fly ash was investigated at unusually high temperatures (650 °C and 850 °C), well above the usual range of de novo tests (250-400 °C). At 650 °C it was found that SDG evolving from dried sewage sludge could suppress the formation of 2,3,7,8-substituted PCDD/Fs with high efficiency (90%), both in weight units and in I-TEQ units. Additionally, at 850 °C, three kinds of sulphur-amine or sulphur-ammonium compounds were tested to inhibit dioxins formation during laboratory-scale tests, simulating municipal solid waste incineration. The suppression efficiencies of PCDD/Fs formed through homogeneous gas phase reactions were all above 85% when 3 wt. % of thiourea (98.7%), aminosulphonic acid (96.0%) or ammonium thiosulphate (87.3%) was added. Differences in the ratio of PCDFs/PCDDs, in weight average chlorination level and in the congener distribution of the 17 toxic PCDD/Fs indicated that the three inhibitors tested followed distinct suppression pathways, possibly in relation to their different functional groups of nitrogen. Furthermore, thiourea reduced the (weight) average chlorinated level. In addition, the thermal decomposition of TUA was studied by means of thermogravimetry-fourier transform infrared spectroscopy (TG-FTIR) and the presence of SO2, SO3, NH3 and nitriles (N≡C bonds) was shown in the decomposition gases; these gaseous inhibitors might be the primary dioxins suppressants.

  16. How to Burst into Contemporaneity?

    Directory of Open Access Journals (Sweden)

    V. I. Zagvyazinsky

    2012-01-01

    Full Text Available The paper, written by V. I. Zagvyazinsky, academician and Chief Editor of «Education and Science» journal, is a comment on the previous issue’s publication of «Pedagogy in the Era of Non-Classical Science» by V. L. Benin. The author continues the discussion about the low quality pedagogic research of the recent years. Among the main reasons for insufficient research level, it is emphasized that young scientists are not quite ready for entering the socio-cultural reality because of their methodological illiteracy and non-compliance with the principles declared by the researchers themselves – i.e. systematism, competence, social and personal orientation, cultural conformity, activity approach, value-semantic orientation of education, foot-hold on the internal mechanisms, variability, dialogism, pedagogic cooperation, etc. The author criticizes the latest trends of so called «breaking into contemporaneity» by pedagogical science - the poly-paradigmatic idea as a new methodological basis of pedagogy; and synergetics as a general pedagogical methodology. Free paradigm constructing by the authors brought about the unreasonable methodological pluralism; whereas the failure of synergetics as methodological basis of pedagogy is related to its incompatibility with the person-oriented individual approach to personality formation. To get rid of the existing shortcomings of pedagogic research the author recommends to organize methodological training courses, schools, seminars, workshops, internship in the scientifically advanced centers that already have postgraduate and doctorate courses along with the fundamental scientific schools. 

  17. Dynamic encoding of natural luminance sequences by LGN bursts.

    Directory of Open Access Journals (Sweden)

    Nicholas A Lesica

    2006-07-01

    Full Text Available In the lateral geniculate nucleus (LGN of the thalamus, visual stimulation produces two distinct types of responses known as tonic and burst. Due to the dynamics of the T-type Ca(2+ channels involved in burst generation, the type of response evoked by a particular stimulus depends on the resting membrane potential, which is controlled by a network of modulatory connections from other brain areas. In this study, we use simulated responses to natural scene movies to describe how modulatory and stimulus-driven changes in LGN membrane potential interact to determine the luminance sequences that trigger burst responses. We find that at low resting potentials, when the T channels are de-inactivated and bursts are relatively frequent, an excitatory stimulus transient alone is sufficient to evoke a burst. However, to evoke a burst at high resting potentials, when the T channels are inactivated and bursts are relatively rare, prolonged inhibitory stimulation followed by an excitatory transient is required. We also observe evidence of these effects in vivo, where analysis of experimental recordings demonstrates that the luminance sequences that trigger bursts can vary dramatically with the overall burst percentage of the response. To characterize the functional consequences of the effects of resting potential on burst generation, we simulate LGN responses to different luminance sequences at a range of resting potentials with and without a mechanism for generating bursts. Using analysis based on signal detection theory, we show that bursts enhance detection of specific luminance sequences, ranging from the onset of excitatory sequences at low resting potentials to the offset of inhibitory sequences at high resting potentials. These results suggest a dynamic role for burst responses during visual processing that may change according to behavioral state.

  18. Characterizing Oscillatory Bursts in Single-Trial EEG Data

    Science.gov (United States)

    Knuth, K. H.; Shah, A. S.; Lakatos, P.; Schroeder, C. E.

    2004-01-01

    Oscillatory bursts in numerous bands ranging from low (theta) to high frequencies (e.g., gamma) undoubtedly play an important role in cortical dynamics. Largely because of the inadequacy of existing analytic techniques. however, oscillatory bursts and their role in cortical processing remains poorly understood. To study oscillatory bursts effectively one must be able to isolate them and characterize them in the single trial. We describe a series of straightforward analysis techniques that produce useful indices of burst characteristics. First, stimulus-evoked responses are estimated using Differentially Variable Component Analysis (dVCA), and are subtracted from the single-trial. The single-trial characteristics of the evoked responses are stored to identify possible correlations with burst activity. Time-frequency (T-F), or wavelet, analyses are then applied to the single trial residuals. While T-F plots have been used in recent studies to identify and isolate bursts, we go further by fitting each burst in the T-F plot with a two-dimensional Gaussian. This provides a set of burst characteristics, such as, center time. burst duration, center frequency. frequency dispersion. and amplitude, all of which contribute to the accurate characterization of the individual burst. The burst phase can also be estimated. Burst characteristics can be quantified with several standard techniques (e.g.. histogramming and clustering), as well as Bayesian techniques (e.g., blocking) to allow a more parametric description analysis of the characteristics of oscillatory bursts, and the relationships of specific parameters to cortical excitability and stimulus integration.

  19. Low-level bromate analysis in drinking water by ion chromatography with optimized suppressed conductivity cell current followed by a post-column reaction and UV/Vis detection.

    Science.gov (United States)

    Fotsing, Marcellin; Barbeau, Benoit; Prevost, Michele

    2011-01-01

    In the present work, a high capacity anion exchange column was used to efficiently and simultaneously separate traces of oxyhalide disinfection byproducts (DBP) anions and bromide by an ion chromatography system followed by a post-column reaction (PCR). The PCR generates in situ hydroiodic (HI) acid from the excess of potassium iodate that combines with bromate from the column effluent to form the triiodide anion detectable by UV/Vis absorbance at 352 nm. The suppressed conductivity cell current was optimized at 70 mA, with a flow rate of 1.0 mL/min and a 9 mM carbonate eluent. Its performance was investigated on a trace-level determination of bromate in ozonated municipal and bottled drinking water. Based on ozonated municipal drinking water matrix, the method detection limit of 0.27 μg BrO(-)(3)/L was evaluated with the Method Quantification Limit (MQL) of 0.89 μg BrO(-)(3)/L. However, in ultrapure water, a MDL of 0.015 μg BrO(-)(3)/L and a MRL of 0.052 μg BrO(-)(3)/L were achieved. The recovery for spiked municipal samples was in the range of 90%-115%.

  20. US Environmental Protection Agency Method 314.1, an automated sample preconcentration/matrix elimination suppressed conductivity method for the analysis of trace levels (0.50 microg/L) of perchlorate in drinking water.

    Science.gov (United States)

    Wagner, Herbert P; Pepich, B V; Pohl, C; Later, D; Joyce, R; Srinivasan, K; Thomas, D; Woodruff, A; Deborba, B; Munch, D J

    2006-06-16

    Since 1997 there has been increasing interest in the development of analytical methods for the analysis of perchlorate. The US Environmental Protection Agency (EPA) Method 314.0, which was used during the first Unregulated Contaminant Monitoring Regulation (UCMR) cycle, supports a method reporting limit (MRL) of 4.0 microg/L. The non-selective nature of conductivity detection, combined with very high ionic strength matrices, can create conditions that make the determination of perchlorate difficult. The objective of this work was to develop an automated, suppressed conductivity method with improved sensitivity for use in the second UCMR cycle. The new method, EPA Method 314.1, uses a 35 mm x 4 mm cryptand concentrator column in the sample loop position to concentrate perchlorate from a 2 mL sample volume, which is subsequently rinsed with 10 mM NaOH to remove interfering anions. The cryptand concentrator column is combined with a primary AS16 analytical column and a confirmation AS20 analytical column. Unique characteristics of the cryptand column allow perchlorate to be desorbed from the cryptand trap and refocused on the head of the guard column for subsequent separation and analysis. EPA Method 314.1 has a perchlorate lowest concentration minimum reporting level (LCMRL) of 0.13 microg/L in both drinking water and laboratory synthetic sample matrices (LSSM) containing up to 1,000 microg/L each of chloride, bicarbonate and sulfate.

  1. Effects of tic suppression: ability to suppress, rebound, negative reinforcement, and habituation to the premonitory urge.

    Science.gov (United States)

    Specht, Matt W; Woods, Douglas W; Nicotra, Cassandra M; Kelly, Laura M; Ricketts, Emily J; Conelea, Christine A; Grados, Marco A; Ostrander, Rick S; Walkup, John T

    2013-01-01

    The comprehensive behavioral intervention for tics (CBIT) represents a safe, effective non-pharmacological treatment for Tourette's disorder that remains underutilized as a treatment option. Contributing factors include the perceived negative consequences of tic suppression and the lack of a means through which suppression results in symptom improvement. Participants (n = 12) included youth ages 10-17 years with moderate-to-marked tic severity and noticeable premonitory urges who met Tourette's or chronic tic disorder criteria. Tic frequency and urge rating data were collected during an alternating sequence of tic freely or reinforced tic suppression periods. Even without specific instructions regarding how to suppress tics, youth experienced a significant, robust (72%), stable reduction in tic frequency under extended periods (40 min) of contingently reinforced tic suppression in contrast to periods of time when tics were ignored. Following periods of prolonged suppression, tic frequency returned to pre-suppression levels. Urge ratings did not show the expected increase during the initial periods of tic suppression, nor a subsequent decline in urge ratings during prolonged, effective tic suppression. Results suggest that environments conducive to tic suppression result in reduced tic frequency without adverse consequences. Additionally, premonitory urges, underrepresented in the literature, may represent an important enduring etiological consideration in the development and maintenance of tic disorders.

  2. Upper limits on gravitational wave bursts in LIGO's second science run

    CERN Document Server

    Abbott, R; Ageev, A; Allen, B; Amin, R; Anderson, S B; Anderson, W G; Araya, M; Armandula, H; Ashley, M; Asiri, F; Aufmuth, P; Aulbert, C; Babak, S; Balasubramanian, R; Ballmer, S; Barish, B C; Barker, C; Barker, D; Barnes, M; Barr, B; Barton, M A; Bayer, K; Beausoleil, R; Belczynski, K; Bennett, R; Berukoff, S J; Betzwieser, J; Bhawal, B; Bilenko, I A; Billingsley, G; Black, E; Blackburn, K; Blackburn, L; Bland, B; Bochner, B; Bogue, L; Bork, R; Bose, S; Brady, P R; Braginsky, V B; Brau, J E; Brown, D A; Bullington, A; Bunkowski, A; Buonanno, A; Burgess, R; Busby, D; Butler, W E; Byer, R L; Cadonati, L; Cagnoli, G; Camp, J B; Cantley, C A; Cardenas, L; Carter, K; Casey, M M; Castiglione, J; Chandler, A; Chapsky, J; Charlton, P; Chatterji, S; Chelkowski, S; Chen, Y; Chickarmane, V; Chin, D; Christensen, N; Churches, D; Cokelaer, T; Colacino, C; Coldwell, R; Coles, M; Cook, D; Corbitt, T; Coyne, D; Creighton, J D E; Creighton, T D; Crooks, D R M; Csatorday, P; Cusack, B J; Cutler, C; D'Ambrosio, E; Danzmann, K; Daw, E; De Bra, D; Delker, T; Dergachev, V; DeSalvo, R; Dhurandhar, S V; Di Credico, A; Díaz, M; Ding, H; Drever, R W P; Dupuis, R J; Edlund, J A; Ehrens, P; Elliffe, E J; Etzel, T; Evans, M; Evans, T; Fairhurst, S; Fallnich, C; Farnham, D; Fejer, M M; Findley, T; Fine, M; Finn, L S; Franzen, K Y; Freise, A; Frey, R; Fritschel, P; Frolov, V V; Fyffe, M; Ganezer, K S; Garofoli, J; Giaime, J A; Gillespie, A; Goda, K; González, G; Goler, S; Grandclément, P; Grant, A; Gray, C; Gretarsson, A M; Grimmett, D; Grote, H; Grünewald, S; Günther, M; Gustafson, E; Gustafson, R; Hamilton, W O; Hammond, M; Hanson, J; Hardham, C; Harms, J; Harry, G; Hartunian, A; Heefner, J; Hefetz, Y; Heinzel, G; Heng, I S; Hennessy, M; Hepler, N; Heptonstall, A; Heurs, M; Hewitson, M; Hild, S; Hindman, N; Hoang, P; Hough, J; Hrynevych, M; Hua, W; Ito, M; Itoh, Y; Ivanov, A; Jennrich, O; Johnson, B; Johnson, W W; Johnston, W R; Jones, D I; Jones, L; Jungwirth, D; Kalogera, V; Katsavounidis, E; Kawabe, K; Kawamura, S; Kells, W; Kern, J; Khan, A; Killbourn, S; Killow, C J; Kim, C; King, C; King, P; Klimenko, S; Koranda, S; Kotter, K; Kovalik, Yu; Kozak, D; Krishnan, B; Landry, M; Langdale, J; Lantz, B; Lawrence, R; Lazzarini, A; Lei, M; Leonor, I; Libbrecht, K; Libson, A; Lindquist, P; Liu, S; Logan, J; Lormand, M; Lubinski, M; Luck, H; Lyons, T T; Machenschalk, B; MacInnis, M; Mageswaran, M; Mailand, K; Majid, W; Malec, M; Mann, F; Marin, A; Marka, S; Maros, E; Mason, J; Mason, K; Matherny, O; Matone, L; Mavalvala, N; McCarthy, R; McClelland, D E; McHugh, M; McNabb, J W C; Mendell, G; Mercer, R A; Meshkov, S; Messaritaki, E; Messenger, C; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Miyakawa, O; Miyoki, S; Mohanty, S; Moreno, G; Mossavi, K; Müller, G; Mukherjee, S; Murray, P; Myers, J; Nagano, S; Nash, T; Nayak, R; Newton, G; Nocera, F; Noel, J S; Nutzman, P; Olson, T; O'Reilly, B; Ottaway, D J; Ottewill, A; Ouimette, D A; Overmier, H; Owen, B J; Pan, Y; Papa, M A; Parameshwaraiah, V; Parameswariah, C; Pedraza, M; Penn, S; Pitkin, M; Plissi, M; Prix, R; Quetschke, V; Raab, F; Radkins, H; Rahkola, R; Rakhmanov, M; Rao, S R; Rawlins, K; Ray-Majumder, S; Re, V; Redding, D; Regehr, M W; Regimbau, T; Reid, S; Reilly, K T; Reithmaier, K; Reitze, D H; Richman, S; Riesen, R; Riles, K; Rivera, B; Rizzi, A; Robertson, D I; Robertson, N A; Robison, L; Roddy, S; Rollins, J; Romano, J D; Romie, J; Rong, H; Rose, D; Rotthoff, E; Rowan, S; Rüdiger, A; Russell, P; Ryan, K; Salzman, I; Sandberg, V; Sanders, G H; Sannibale, V; Sathyaprakash, B; Saulson, P R; Savage, R; Sazonov, A; Schilling, R; Schlaufman, K; Schmidt, V; Schnabel, R; Schofield, R; Schutz, B F; Schwinberg, P; Scott, S M; Seader, S E; Searle, A C; Sears, B; Seel, S; Seifert, F; Sengupta, A S; Shapiro, C A; Shawhan, P; Shoemaker, D H; Shu, Q Z; Sibley, A; Siemens, X; Sievers, L; Sigg, D; Sintes, A M; Smith, J R; Smith, M; Smith, M R; Sneddon, P H; Spero, R; Stapfer, G; Steussy, D; Strain, K A; Strom, D; Stuver, A; Summerscales, T; Sumner, M C; Sutton, P J; Sylvestre, J; Takamori, A; Tanner, D B; Tariq, H; Taylor, I; Taylor, R; Thorne, K A; Thorne, K S; Tibbits, M; Tilav, S; Tinto, M; Tokmakov, K V; Torres, C; Torrie, C; Traylor, G; Tyler, W; Ugolini, D W; Ungarelli, C; Vallisneri, M; Van Putten, M H P M; Vass, S; Vecchio, A; Veitch, J; Vorvick, C; Vyachanin, S P; Wallace, L; Walther, H; Ward, H; Ware, B; Watts, K; Webber, D; Weidner, A; Weiland, U; Weinstein, A; Weiss, R; Welling, H; Wen, L; Wen, S; Whelan, J T; Whitcomb, S E; Whiting, B F; Wiley, S; Wilkinson, C; Willems, P A; Williams, P R; Williams, R; Willke, B; Wilson, A; Winjum, B J; Winkler, W; Wise, S; Wiseman, A G; Woan, G; Wooley, R; Worden, J; Wu, W; Yakushin, I; Yamamoto, H; Yoshida, S; Zaleski, K D; Zanolin, M; Zawischa, I; Zhang, L; Zhu, R; Zotov, N P; Zucker, M; Zweizig, J

    2005-01-01

    We perform a search for gravitational wave bursts using data from the second science run of the LIGO detectors, using a method based on a wavelet time-frequency decomposition. This search is sensitive to bursts of duration much less than a second and with frequency content in the 100-1100Hz range. It features significant improvements in the instrument sensitivity and in the analysis pipeline with respect to the burst search previously reported by LIGO. Improvements in the search method allow exploring weaker signals, relative to the detector noise floor, while maintaining a low false alarm rate, O(0.1) microHz. The sensitivity in terms of the root-sum-square (rss) strain amplitude lies in the range of hrss~10^{-20} - 10^{-19}/sqrt(Hz) No gravitational wave signals were detected in 9.98 days of analyzed data. We interpret the search result in terms of a frequentist upper limit on the rate of detectable gravitational wave bursts at the level of 0.26 events per day at 90% confidence level. We combine this limit ...

  3. Gamma-Ray Bursts and the Earth: Exploration of Atmospheric, Biological, Climatic and Biogeochemical Effects

    CERN Document Server

    Thomas, B C; Jackman, C H; Laird, C M; Medvedev, M V; Stolarski, R S; Gehrels, N; Cannizzo, J K; Hogan, D P; Ejzak, L M; Thomas, Brian C.; Melott, Adrian L.; Jackman, Charles H.; Laird, Claude M.; Medvedev, Mikhail V.; Stolarski, Richard S.; Gehrels, Neil; Cannizzo, John K.; Hogan, Daniel P.; Ejzak, Larissa M.

    2005-01-01

    Gamma-Ray Bursts (GRBs) are likely to have made a number of significant impacts on the Earth during the last billion years. We have used a two-dimensional atmospheric model to investigate the effects on the Earth's atmosphere of GRBs delivering a range of fluences, at various latitudes, at the equinoxes and solstices, and at different times of day. We have estimated DNA damage levels caused by increased solar UVB radiation, reduction in solar visible light due to $\\mathrm{NO_2}$ opacity, and deposition of nitrates through rainout of $\\mathrm{HNO_3}$. For the ``typical'' nearest burst in the last billion years, we find globally averaged ozone depletion up to 38%. Localized depletion reaches as much as 74%. Significant global depletion (at least 10%) persists up to about 7 years after the burst. Our results depend strongly on time of year and latitude over which the burst occurs. We find DNA damage of up to 16 times the normal annual global average, well above lethal levels for simple life forms such as phytopl...

  4. Priming theta-burst repetitive transcranial magnetic stimulation with low- and high-frequency stimulation.

    Science.gov (United States)

    Todd, Gabrielle; Flavel, Stanley C; Ridding, Michael C

    2009-05-01

    Repetitive transcranial magnetic stimulation (rTMS) can be used to study metaplasticity in human motor cortex. The term metaplasticity describes a phenomenon where the prior synaptic history of a pathway can affect the subsequent induction of long-term potentiation or depression. In the current study, we investigated metaplasticity in human motor cortex with the use of inhibitory continuous theta-burst stimulation (cTBS). cTBS involves short bursts of high frequency (50 Hz) rTMS applied every 200 ms for 40 s. In the first series of experiments, cTBS was primed with 10 min of intermittent 2 or 6 Hz rTMS. Subjects (n = 20) received priming stimulation at 70% of active motor threshold or 90% of resting motor threshold. In another series of experiments, cTBS was primed with excitatory intermittent theta-burst stimulation (iTBS). iTBS involves a 2 s train of theta-burst stimulation delivered every 10 s for 190 s. Stimuli were delivered over the first dorsal interosseus motor area.. The effect of cTBS alone and primed cTBS on motor cortical excitability was investigated by recording motor-evoked potentials (MEP) in the first dorsal interosseus following single-pulse TMS. MEP area in the cTBS alone condition was not significantly different from cTBS primed with 2 or 6 Hz rTMS. However, priming cTBS with iTBS suppressed MEP area to a greater extent than in cTBS alone. Our results provide further evidence of metaplasticity in human motor cortex when appropriate priming protocols are employed.

  5. Gamma-Ray Bursts in the Swift Era

    CERN Document Server

    Gehrels, N; Fox, D B; 10.1146/annurev.astro.46.060407.145147

    2009-01-01

    With its rapid-response capability and multiwavelength complement of instruments, the Swift satellite has transformed our physical understanding of gamma-ray bursts (GRBs). Providing high-quality observations of hundreds of bursts, and facilitating a wide range of follow-up observations within seconds of each event, Swift has revealed an unforeseen richness in observed burst properties, shed light on the nature of short-duration bursts, and helped realize the promise of GRBs as probes of the processes and environments of star formation out to the earliest cosmic epochs. These advances have opened new perspectives on the nature and properties of burst central engines, interactions with the burst environment from microparsec to gigaparsec scales, and the possibilities for non-photonic signatures. Our understanding of these extreme cosmic sources has thus advanced substantially; yet more than 40 years after their discovery, GRBs continue to present major challenges on both observational and theoretical fronts.

  6. Generation of burst time plans for the Intelsat TDMA system

    Science.gov (United States)

    Trusty, P. A.; King, C. A.; Roach, P. W.

    In the Intelsat time-division multiple-access (TDMA) system, the burst time plan (BTP) contains the assignments of traffic and reference bursts, common acquisition windows, and test slots to time slots within the TDMA frame for a given network. Generation of the BTP involves the processes of sub-burst formation, burst formation, reference burst assignments, and burst scheduling. BTP information is transferred to the individual reference and traffic stations in the form of a master time plan (MTP) and a condensed time plan (CTP). This paper describes algorithms which have been developed for each of the BTP generation processes, as well as those algorithms and procedures used to generate the MTPs and CTPs. A software system which implements these algorithms is also discussed.

  7. Ultrastable bonding of glass with femtosecond laser bursts

    Science.gov (United States)

    Richter, Sören; Zimmermann, Felix; Döring, Sven; Tünnermann, Andreas; Nolte, Stefan

    2013-03-01

    We report on the welding of fused silica with bursts of ultrashort laser pulses. The bursts consist of ultrashort laser pulses with a repetition rate of 9.4 MHz. However, the time between the laser bursts is about 10 μs, which reduces the maximal temperature rise. Micrographs and simulations show that the molten structures are enlarged while using laser bursts. In addition, the usage of bursts instead of continuous pulse trains reduces the laser induced stress. By optimizing the burst frequency and repetition rate we were able to achieve a breaking resistance of up to 96% of the bulk material, which is significantly higher than in conventional high repetition rate laser bonding.

  8. Millihertz quasi-periodic oscillations in 4U 1636-53 associated with bursts with positive convexity only

    CERN Document Server

    Lyu, Ming; Altamirano, Diego; Zhang, Guobao

    2016-01-01

    We investigated the convexity of all type I X-ray bursts with millihertz quasi-periodic oscillations (mHz QPOs) in 4U 1636-53 using archival observations with the Rossi X-ray Timing Explorer. We found that, at a 3.5 $\\sigma$ confidence level, in all 39 cases in which the mHz QPOs disappeared at the time of an X-ray burst, the convexity of the burst is positive. The convexity measures the shape of the rising part of the burst light curve and, according to recent models, it is related to the ignition site of bursts on the neutron star surface. This finding suggests that in 4U 1636-53 these 39 bursts and the marginally-stable nuclear burning process responsible for the mHz QPOs take place at the neutron-star equator. This scenario could explain the inconsistency between the high accretion rate required for triggering mHz QPOs in theoretical models and the relatively low accretion rate derived from observations.

  9. Millihertz quasi-periodic oscillations in 4U 1636-53 associated with bursts with positive convexity only

    Science.gov (United States)

    Lyu, Ming; Méndez, Mariano; Altamirano, Diego; Zhang, Guobao

    2016-12-01

    We investigated the convexity of all type I X-ray bursts with millihertz quasi-periodic oscillations (mHz QPOs) in 4U 1636-53 using archival observations with the Rossi X-ray Timing Explorer. We found that, at a 3.5σ confidence level, in all 39 cases in which the mHz QPOs disappeared at the time of an X-ray burst, the convexity of the burst is positive. The convexity measures the shape of the rising part of the burst light curve and, according to recent models, it is related to the ignition site of bursts on the neutron-star surface. This finding suggests that in 4U 1636-53 these 39 bursts and the marginally stable nuclear burning process responsible for the mHz QPOs take place at the neutron-star equator. This scenario could explain the inconsistency between the high accretion rate required for triggering mHz QPOs in theoretical models and the relatively low accretion rate derived from observations.

  10. Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation.

    Directory of Open Access Journals (Sweden)

    Chitra Dhanasekar

    Full Text Available Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-inflammatory effect against adjuvant-induced arthritic rats. In this current study, we investigated the anti-inflammatory mechanism of morin against monosodium urate crystal (MSU-induced inflammation in RAW 264.7 macrophage cells, an in vitro model for acute gouty arthritis. For comparison purpose, colchicine was used as a reference drug. We have observed that morin (100-300 μM treatment significantly suppressed the levels of inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1 and VEGF, inflammatory mediators (NO and PEG2, and lysosomal enzymes (acid phosphatase, β-galactosidase, N-acetyl glucosamindase and cathepsin D in MSU-crystals stimulated macrophage cells. The mRNA expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1, inflammatory enzymes (iNOS and COX-2, and NF-κBp65 was found downregulated in MSU crystal stimulated macrophage cells by morin treatment, however, the mRNA expression of hypoxanthine phospho ribosyl transferse (HPRT was found to be increased. The flow cytometry analysis revealed that morin treatment decreased intracellular reactive oxygen species levels in MSU crystal stimulated macrophage cells. The western blot analysis clearly showed that morin mainly exerts its anti-inflammatory effects by inhibiting the MSU crystal-induced COX-2 and TNF-α protein expression through the inactivation of NF-κB signaling pathway in RAW 264.7 macrophage cells similar to that of BAY 11-7082 (IκB kinase inhibitor. Our results collectively suggest that morin can be a potential therapeutic agent for inflammatory disorders like acute gouty arthritis.

  11. Effect of Byrsonima crassa and Phenolic Constituents on Helicobacter pylori-Induced Neutrophils Oxidative Burst

    Directory of Open Access Journals (Sweden)

    Wagner Vilegas

    2011-12-01

    Full Text Available Byrsonima crassa Niedenzu (Malpighiaceae is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+-catechin > methanol extract > quercetin 3-O-α-l-arabinopyranoside > quercetin 3-O-β-d-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 µg/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms.

  12. The bursting of housing bubble as jamming phase transition

    Science.gov (United States)

    Nishinari, Katsuhiro; Iwamura, Mitsuru; Umeno Saito, Yukiko; Watanabe, Tsutomu

    2010-04-01

    In this paper, we have proposed a bubble burst model by focusing on transaction volume incorporating a traffic model that represents spontaneous traffic jam. We find that the phenomenon of bubble burst shares many similar properties with traffic jam formation on highway by comparing data taken from the U.S. housing market. Our result suggests that transaction volume could be a driving force of bursting phenomenon.

  13. Physical characterization of the Skua fast burst assembly

    Energy Technology Data Exchange (ETDEWEB)

    Paternoster, R.; Bounds, J.; Sanchez, R.; Miko, D.

    1994-08-01

    In this paper we discuss the system design and ongoing efforts to characterize the machine physics and operating properties of the Skua fast burst assembly. The machine is currently operating up to prompt critical while we await approval for super-prompt burst operations. Efforts have centered on characterizing neutron kinetic properties, comparing calculated and measured temperature coefficients and power distributions, improving the burst reproducibility, examining the site-wide dose characteristics, and fitting the machine with cooling and filtration systems.

  14. Extremely long hard bursts observed by Konus-Wind

    CERN Document Server

    Pal'shin, V; Frederiks, D; Golenetskii, S; Il'Inskii, V; Mazets, E; Yamaoka, K; Ohno, M; Hurley, K; Sakamoto, T; Oleynik, P; Ulanov, M; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Shinohara, C; Starr, R; 10.1063/1.2943422

    2013-01-01

    We report the observations of the prompt emission of the extremely long hard burst, GRB 060814B, discovered by Konus-Wind and localized by the IPN. The observations reveal a smooth, hard, ~40-min long pulse followed by weaker emission seen several hours after the burst onset. We also present the Konus-Wind data on similar burst, GRB 971208, localized by BATSE/IPN. And finally we discuss the different possible origins of these unusual events.

  15. Burst error correction extensions for large Reed Solomon codes

    Science.gov (United States)

    Owsley, P.

    1990-01-01

    Reed Solomon codes are powerful error correcting codes that include some of the best random and burst correcting codes currently known. It is well known that an (n,k) Reed Solomon code can correct up to (n - k)/2 errors. Many applications utilizing Reed Solomon codes require corrections of errors consisting primarily of bursts. In this paper, it is shown that the burst correcting ability of Reed Solomon codes can be increased beyond (n - k)/2 with an acceptable probability of miscorrect.

  16. Gamma-ray burst engines may have no memory

    CERN Document Server

    Baldeschi, A

    2014-01-01

    A sizeable fraction of gamma-ray burst (GRB) time profiles consist of a temporal sequence of pulses. The nature of this stochastic process carries information on how GRB inner engines work. The so-called interpulse time defines the interval between adjacent pulses, excluding the long quiescence periods during which the signal drops to the background level. It was found by many authors in the past that interpulse times are lognormally distributed, at variance with the exponential case that is expected for a memoryless process. We investigated whether the simple hypothesis of a temporally uncorrelated sequence of pulses is really to be rejected, as a lognormal distribution necessarily implies. We selected and analysed a number of multi--peaked CGRO/BATSE GRBs and simulated similar time profiles, with the crucial difference that we assumed exponentially distributed interpulse times, as is expected for a memoryless stationary Poisson process. We then identified peaks in both data sets using a novel peak search al...

  17. Are long gamma-ray bursts standard candles?

    CERN Document Server

    Lin, Hai-Nan; Wang, Sai; Chang, Zhe

    2015-01-01

    Gamma-ray bursts (GRBs) are widely proposed as an effective probe to trace the Hubble diagram of the Universe in high redshift range. However, the calibration of GRBs is not as easy as that of type-Ia supernovae (SNe Ia). Most calibrating methods at present take use one or some of the empirical luminosity corrections, e.g., Amati relation. One of the underlying assumptions of these calibrating methods is that the empirical correlation is universal over all redshifts. In this paper, we check to what extent this assumption holds. Assuming that SNe Ia exactly trace the Hubble diagram of the Universe, we re-investigate the Amati relation for low redshift ($z1.4$) GRBs, respectively. It is found that the Amati relation of low-$z$ GRBs differs from that of high-$z$ GRBs at more than $3\\sigma$ confidence level. This result is insensitive to cosmological models.

  18. Gamma Ray Burst as Sources of Exotic Particles

    CERN Document Server

    Morgan, Ian; De Pree, Erin; Tennyson, Kevin

    2015-01-01

    We consider the possible production of stable lightest first level KK particle (LKP) in baryonic gamma ray bursts (GRB) out flows. We numerically computed the energy-dependent cross-sections of Kaluza-Klein (KK) excitations for the Standard Model gauge bosons, photon and Z. Next, we determined the feasibility of producing these KK excitations in gamma-ray emitting regions of GRBs. We found that a GRB fireball that accelerates baryons to energies greater than 10^14 eV could produce KK excitations out to approximately 10^12 cm from the central engine, indicating that GRBs may be a significant source of the LKP. Finally, we explore the potential observational consequences of our results.

  19. CYTOKINE REGULATION OF RESPIRATORY BURST IN BLOOD NEUTROPHILS FOR PREDICTION OF ABDOMINAL SEPSIS IN PATIENTS WITH EXTENDED PURULENT PERITONITIS

    Directory of Open Access Journals (Sweden)

    A. A. Savchenko

    2016-01-01

    Full Text Available The aim of this study was to evaluate correlations between cytokine concentrations and parameters of respiratory burst in blood neutrophils, in order to predict potential development of abdominal sepsis in the patients with extended purulent peritonitis (EPP. The study involved fifteen patients with EPP. Peripheral blood samples were taken on the first day post-admissiona. Abdominal sepsis was diagnosed in thirty-five patients (70% within 5…10 days after surgical intervention. Clinical complications were absent in fifteen patients (30%. Sixty-seven healthy individuals were examined as a control group. Evaluation of the cytokine concentrations was performed by ELISA technique. The degree of respiratory burst in blood neutrophils was measured by means of chemiluminescence assay.It is revealed that the EPP patients exhibited increased levels of serum proinflammatory cytokines and IFNγ, along with higher intensity of respiratory burst in blood neutrophils, due to activated synthesis of of both primary and secondary reactive oxygen species (ROS. The EPP patients who later developed abdominal sepsis showed reduced spontaneous synthesis of primary ROS and increased spontaneous synthesis of secondary ROS. Upon zymosan induction of neutrophils, both primary and secondary ROS levels proved to be similar in the EPP subgroups with or without subsequent sepsis. EPP patients with uncomplicated post-surgical period still exhibited a predominant regulation of respiratory burst of neutrophils by IFNγ activity. Meanwhile, the neutrophil respiratory burst was correlated with TNFα and IL-6 in those patients who further developed abdominal sepsis. A stimulatory effect of IFNγ and a presumably inhibitory action of TNFα and IL-6 upon respiratory burst of blood neutrophils in EPP patients are associated with a release of large cytokine amounts during acute immune inflammatory events, and migration of activated cells to the inflammatory focus. In particular, the

  20. Spectral Lag Evolution among -Ray Burst Pulses

    Indian Academy of Sciences (India)

    Lan-Wei Jia; Yun-Feng Liang; En-Wei Liang

    2014-09-01

    We analyse the spectral lag evolution of -ray burst (GRB) pulses with observations by CGRO/BATSE. No universal spectral lag evolution feature and pulse luminosity-lag relation within a GRB is observed.Our results suggest that the spectral lag would be due to radiation physics and dynamics of a given emission episode, possibly due to the longer lasting emission in a lower energy band, and the spectral lag may not be an intrinsic parameter to discriminate the long and short GRBs.

  1. The Nature of Gamma Ray Burst Supernovae

    OpenAIRE

    Cano, Zach

    2012-01-01

    Gamma Ray Bursts (GRBs) and Supernovae (SNe) are among the brightest and most energetic physical processes in the universe. It is known that core-collapse SNe arise from the gravitational collapse and subsequent explosion of massive stars (the progen- itors of nearby core-collapse SNe have been imaged and unambiguously identified). It is also believed that the progenitors of long-duration GRBs (L-GRBs) are massive stars, mainly due to the occurrence and detection of very energetic core-collap...

  2. Gamma Ray Bursts in the HAWC Era

    CERN Document Server

    Mészáros, Peter; Murase, Kohta; Fox, Derek; Gao, He; Senno, Nicholas

    2015-01-01

    Gamma-Ray Bursts are the most energetic explosions in the Universe, and are among the most promising for detecting multiple non-electromagnetic signals, including cosmic rays, high energy neutrinos and gravitational waves. The multi-GeV to TeV gamma-ray range of GRB could have significant contributions from hadronic interactions, mixed with more conventional leptonic contributions. This energy range is important for probing the source physics, including overall energetics, the shock parameters and the Lorentz factor. We discuss some of the latest observational and theoretical developments in the field.

  3. Properties of $\\gamma$-Ray Burst Classes

    CERN Document Server

    Hakkila, J; Roiger, R J; Mallozzi, R S; Pendleton, G N; Meegan, C A; Hakkila, Jon; Haglin, David J.; Roiger, Richard J.; Mallozzi, Robert S.; Pendleton, Geoffrey N.; Meegan, Charles A.

    2000-01-01

    The three gamma-ray burst (GRB) classes identified by statistical clustering analysis (Mukherjee et al. 1998) are examined using the pattern recognition algorithm C4.5 (Quinlan 1986). Although the statistical existence of Class 3 (intermediate duration, intermediate fluence, soft) is supported, the properties of this class do not need to arise from a distinct source population. Class 3 properties can easily be produced from Class 1 (long, high fluence, intermediate hardness) by a combination of measurement error, hardness/intensity correlation, and a newly-identified BATSE bias (the fluence duration bias). Class 2 (short, low fluence, hard) does not appear to be related to Class 1.

  4. Burst-Mode Asynchronous Controllers on FPGA

    Directory of Open Access Journals (Sweden)

    Duarte L. Oliveira

    2008-01-01

    Full Text Available FPGAs have been mainly used to design synchronous circuits. Asynchronous design on FPGAs is difficult because the resulting circuit may suffer from hazard problems. We propose a method that implements a popular class of asynchronous circuits, known as burst mode, on FPGAs based on look-up table architectures. We present two conditions that, if satisfied, guarantee essential hazard-free implementation on any LUT-based FPGA. By doing that, besides all the intrinsic advantages of asynchronous over synchronous circuits, they also take advantage of the shorter design time and lower cost associated with FPGA designs.

  5. Bursting frequency prediction in turbulent boundary layers

    Energy Technology Data Exchange (ETDEWEB)

    LIOU,WILLIAM W.; FANG,YICHUNG

    2000-02-01

    The frequencies of the bursting events associated with the streamwise coherent structures of spatially developing incompressible turbulent boundary layers were predicted using global numerical solution of the Orr-Sommerfeld and the vertical vorticity equations of hydrodynamic stability problems. The structures were modeled as wavelike disturbances associated with the turbulent mean flow. The global method developed here involves the use of second and fourth order accurate finite difference formula for the differential equations as well as the boundary conditions. An automated prediction tool, BURFIT, was developed. The predicted resonance frequencies were found to agree very well with previous results using a local shooting technique and measured data.

  6. Nucleosynthetic Yields from Gamma-Ray Bursts

    CERN Document Server

    Rockefeller, Gabriel; Young, Patrick; Bennett, Michael; Diehl, Steven; Herwig, Falk; Hirschi, Raphael; Hungerford, Aimee; Pignatari, Marco; Magkotsios, Georgios; Timmes, Francis X

    2008-01-01

    The "collapsar" engine for gamma-ray bursts invokes as its energy source the failure of a normal supernova and the formation of a black hole. Here we present the results of the first three-dimensional simulation of the collapse of a massive star down to a black hole, including the subsequent accretion and explosion. The explosion differs significantly from the axisymmetric scenario obtained in two-dimensional simulations; this has important consequences for the nucleosynthetic yields. We compare the nucleosynthetic yields to those of hypernovae. Calculating yields from three-dimensional explosions requires new strategies in post-process nucleosynthesis; we discuss NuGrid's plan for three-dimensional yields.

  7. A polarised fast radio burst at low Galactic latitude

    Science.gov (United States)

    Petroff, Emily; SUPERB Collaboration; HESS Collaboration; ANTARES Collaboration

    2017-01-01

    Fast radio bursts (FRBs) are a growing population of transients detected with radio telescopes which are thought to originate outside the Milky Way. Fewer than 20 sources exist in the literature and the majority of bursts have been found away from the plane of the Galaxy or where the Galactic contribution to the total electron column density is low. Here we report on the discovery of a new burst, FRB 150215, discovered with the Parkes radio telescope in real-time in February 2015. The burst was found to be 43±5% linearly polarised with an imprecisely determined rotation measure (RM) consistent with zero. The burst was followed-up with 9 telescopes to search for radio, optical, X-ray, γ-ray and neutrino emission from the location of the burst. No transient or variable emission was found to be associated with the burst and no repeat pulses have been observed in nine hours of Parkes observations. Radio images of the field were obtained following the FRB but would not have been sensitive enough to pick up a signal like the one emanating from WISE J071634.59-190039.2 following FRB150418 if it had been present. The sightline to the burst is close to the Galactic plane and the Galactic RM foreground may approach a null along this sightline, corresponding to a decreased total electron column density from the Milky Way. This might explain why this burst was detectable at low latitude whereas previous searches have been relatively unsuccessful.

  8. Ablation of steel using picosecond laser pulses in burst mode

    Science.gov (United States)

    Lickschat, Peter; Demba, Alexander; Weissmantel, Steffen

    2017-02-01

    Results obtained in picosecond laser processing of steel applying the burst mode are presented. Using the burst mode, pulse trains, i.e., bursts, consisting of a number of picosecond pulses with an inter-pulse delay of 12.5 ns and 10 ps pulse duration are applied for material processing. Small cavities with sizes in the range of the laser beam diameter made by single-burst ablation are compared to quadratic cavities of 0.5 × 0.5 mm² produced by multiburst ablation and simultaneous scanning of the laser beam across the steel sample surface. The ablated volume per pulse within the burst was calculated either from the ablated volume per burst or from the ablation depth of the quadratic cavities. With the second to fourth pulses in the bursts, a reduction of the ablated volume per pulse in comparison with the first pulse in the bursts (i.e., to the use of single pulses) was found for both single- and multiburst ablation, which is assumed to be due to plasma shielding. By contrast, the ablated volume per pulse within the bursts increases for the fifth to eighth pulses. Heat accumulation effect and the influence of the heated plasma can be assumed to be the reason for these higher ablation rates. SEM micrographs also show that there is a higher melt ejection out of the laser processed area. This is indicated by the formation of bulges about the ablated area.

  9. The long and the short of gamma-ray bursts

    CERN Document Server

    Katz, J I

    1995-01-01

    We report evidence from the 3B Catalogue that long (T_{90} > 10 s) and short (T_{90} 1 MeV. This implies different spatial origin and physical processes for long and short bursts. Long bursts may be explained by accretion-induced collapse. Short bursts require another mechanism, for which we suggest neutron star collisions. These are capable of producing neutrino bursts as short as a few ms, consistent with the shortest observed time scales in GRB. We briefly investigate the parameters of clusters in which neutron star collisons may occur, and discuss the nuclear evolution of expelled and accelerated matter.

  10. Statistical Properties of SGR 1806-20 Bursts.

    Science.gov (United States)

    Göğüş; Woods; Kouveliotou; van Paradijs J; Briggs; Duncan; Thompson

    2000-04-01

    We present statistics of SGR 1806-20 bursts, combining 290 events detected with the Rossi X-Ray Timing Explorer/Proportional Counter Array, 111 events detected with the Burst and Transient Source Experiment, and 134 events detected with the International Cometary Explorer. We find that the fluence distribution of bursts observed with each instrument are well described by power laws with indices 1.43, 1.76, and 1.67, respectively. The distribution of time intervals between successive bursts from SGR 1806-20 is described by a lognormal function with a peak at 103 s. There is no correlation between the burst intensity and either the waiting times until the next burst or the time elapsed since the previous burst. In all these statistical properties, SGR 1806-20 bursts resemble a self-organized critical system, similar to earthquakes and solar flares. Our results thus support the hypothesis that the energy source for soft gamma repeater bursts is crustquakes due to the evolving, strong magnetic field of the neutron star, rather than any accretion or nuclear power.

  11. Observations of cosmic gamma ray bursts with WATCH on EURECA

    DEFF Research Database (Denmark)

    Brandt, Søren; Lund, N.; Castro-Tirado, A. J.

    1995-01-01

    19 Cosmic Gamma-Ray Bursts were detected by the WATCH wide field X-ray monitor during the 11 months flight of EURECA. The identification of the bursts were complicated by a high frequency of background of events caused by high energy cosmic ray interactions in the detector and by low energy......, trapped particle streams. These background events may simulate the count rate increases characteristic of cosmic gamma bursts. For 12 of the detected events, their true cosmic nature have been confirmed through consistent localizations of the burst sources based on several independent WATCH data sets...

  12. A behavioral role for feature detection by sensory bursts.

    Science.gov (United States)

    Marsat, Gary; Pollack, Gerald S

    2006-10-11

    Brief episodes of high-frequency firing of sensory neurons, or bursts, occur in many systems, including mammalian auditory and visual systems, and are believed to signal the occurrence of particularly important stimulus features, i.e., to function as feature detectors. However, the behavioral relevance of sensory bursts has not been established in any system. Here, we show that bursts in an identified auditory interneuron of crickets reliably signal salient stimulus features and reliably predict behavioral responses. Our results thus demonstrate the close link between sensory bursts and behavior.

  13. A Limited Deflection Routing Algorithm Based on Burst Loss Threshold in OBS Networks

    Institute of Scientific and Technical Information of China (English)

    WANG Ru-yan; LONG Ke-ping; WU Wei; YANG Xiao-long; ZHU Wei-le

    2005-01-01

    The deflection routing protocol is an effective contention resolution in Optical Burst Switching network. However, it can worsen loss performance of non-deflected burst on the deflection route. To improve the burst loss performance, a limited deflection routing scheme based on burst loss threshold is proposed to prevent injudicious deflection routing. By using threshold check function, it restrainedly allows the deflected burst to preemptive network resource, consequently, improve the QoS performance of non-deflected burst. Simulation results show that the scheme can efficiently prevent deflected burst contending with non-deflected burst on deflection route, and effectively improve the burst loss performance of entire networks.

  14. The repeating Fast Radio Burst FRB 121102: Multi-wavelength observations and additional bursts

    CERN Document Server

    Scholz, P; Hessels, J W T; Chatterjee, S; Cordes, J M; Kaspi, V M; Wharton, R S; Bassa, C G; Bogdanov, S; Camilo, F; Crawford, F; Deneva, J; van Leeuwen, J; Lynch, R; Madsen, E C; McLaughlin, M A; Mickaliger, M; Parent, E; Patel, C; Ransom, S M; Seymour, A; Stairs, I H; Stappers, B W; Tendulkar, S P

    2016-01-01

    We report on radio and X-ray observations of the only known repeating Fast Radio Burst (FRB) source, FRB 121102. We have detected six additional radio bursts from this source: five with the Green Bank Telescope at 2 GHz, and one at 1.4 GHz at the Arecibo Observatory for a total of 17 bursts from this source. All have dispersion measures consistent with a single value ($\\sim559$ pc cm$^{-3}$) that is three times the predicted maximum Galactic value. The 2-GHz bursts have highly variable spectra like those at 1.4 GHz, indicating that the frequency structure seen across the individual 1.4 and 2-GHz bandpasses is part of a wideband process. X-ray observations of the FRB 121102 field with the Swift and Chandra observatories show at least one possible counterpart; however, the probability of chance superposition is high. A radio imaging observation of the field with the Jansky Very Large Array at 1.6 GHz yields a 5$\\sigma$ upper limit of 0.3 mJy on any point-source continuum emission. This upper limit, combined wit...

  15. The Second SWIFT Burst Alert Telescope (BAT) Gamma-Ray Burst Catalog

    Science.gov (United States)

    Sakamoto, T.; Barthelmy, S. D.; Baumgartner, W. H.; Cummings, J. R.; Fenimore, E. E.; Gehrels, N.; Krimm, H. A.; Markwardt, C. B.; Palmer, D. M.; Parsons, A. M.; Sato, G.; Stamatikos, M.; Tueller, J.; Ukwatta, T. N.; Zhang, B.

    2012-01-01

    We present the second Swift Burst Alert Telescope (BAT) catalog of gamma-ray bursts. (GRBs), which contains 476 bursts detected by the BAT between 2004 December 19 and 2009 December 21. This catalog (hereafter the BAT2 catalog) presents burst trigger time, location, 90% error radius, duration, fluence, peak flux, time-averaged spectral parameters and time-resolved spectral parameters measured by the BAT. In the correlation study of various observed parameters extracted from the BAT prompt emission data, we distinguish among long-duration GRBs (L-GRBs), short-duration GRBs (S-GRBs), and short-duration GRBs with extended emission (S-GRBs with E.E.) to investigate differences in the prompt emission properties. The fraction of L-GRBs, S-GRBs and S-GRBs with E.E. in the catalog are 89%, 8% and 2% respectively. We compare the BAT prompt emission properties with the BATSE, BeppoSAX and HETE-2 GRB samples.. We also correlate the observed prompt emission properties with the redshifts for the GRBs with known redshift. The BAT T(sub 90) and T(sub 50) durations peak at 70 s and 30 s, respectively. We confirm that the spectra of the BAT S-GRBs are generally harder than those of the L-GRBs.

  16. Suppression as a stereotype control strategy.

    Science.gov (United States)

    Monteith, M J; Sherman, J W; Devine, P G

    1998-01-01

    Recent research reveals that efforts to suppress stereotypic thoughts can backfire and produce a rebound effect, such that stereotypic thinking increases to a level that is even greater than if no attempt at stereotype control was initially exercised (e.g., Macrae, Bodenhausen, Milne, & Jetten, 1994). The primary goal of this article is to present an in-depth theoretical analysis of stereotype suppression that identifies numerous potential moderators of the effect of stereotype suppression on the likelihood of subsequent rebound. Our analysis of stereotype suppression focuses on two broad issues: the influence of level of prejudice and the influence of processing goals on the activation versus application of stereotypes. Although stereotype rebound occurs under some circumstances, we suggest that a complete understanding of this phenomenon requires consideration of the full array of possible moderating influences.

  17. Endogenous activation of adenosine A1 receptors promotes post-ischemic electrocortical burst suppression

    DEFF Research Database (Denmark)

    Ilie, A; Ciocan, D; Constantinescu, A O

    2009-01-01

    . Several lines of evidence suggest that BS reflects an impairment of neocortical connectivity. Here we tested in vivo whether synaptic depression by adenosine A1 receptor (A1R) activation contributes to BS patterns following GCI. Male Wistar rats were subjected to 1, 5 or 10 min of GCI using a "four...... of post-ischemic BS patterns following brief ischemic episodes. It is likely that synaptic depression by post-ischemic A1R activation functionally disrupts the connectivity within the cortical networks to an extent that promotes BS patterns....

  18. Photospheric Emission in Gamma-Ray Bursts

    CERN Document Server

    Pe'er, Asaf

    2016-01-01

    A major breakthrough in our understanding of gamma-ray bursts (GRB) prompt emission physics occurred in the last few years, with the realization that a thermal component accompanies the over-all non-thermal prompt spectra. This thermal part is important by itself, as it provides direct probe of the physics in the innermost outflow regions. It further has an indirect importance, as a source of seed photons for inverse-Compton scattering, thereby it contributes to the non-thermal part as well. In this short review, we highlight some key recent developments. Observationally, although so far it was clearly identified only in a minority of bursts, there are indirect evidence that thermal component exists in a very large fraction of GRBs, possibly close to 100%. Theoretically, the existence of thermal component have a large number of implications as a probe of underlying GRB physics. Some surprising implications include its use as a probe of the jet dynamics, geometry and magnetization.

  19. Short-Duration Gamma-Ray Bursts

    CERN Document Server

    Berger, Edo

    2013-01-01

    Gamma-ray bursts (GRBs) display a bimodal duration distribution, with a separation between the short- and long-duration bursts at about 2 sec. The progenitors of long GRBs have been identified as massive stars based on their association with Type Ic core-collapse supernovae, their exclusive location in star-forming galaxies, and their strong correlation with bright ultraviolet regions within their host galaxies. Short GRBs have long been suspected on theoretical grounds to arise from compact object binary mergers (NS-NS or NS-BH). The discovery of short GRB afterglows in 2005, provided the first insight into their energy scale and environments, established a cosmological origin, a mix of host galaxy types, and an absence of associated supernovae. In this review I summarize nearly a decade of short GRB afterglow and host galaxy observations, and use this information to shed light on the nature and properties of their progenitors, the energy scale and collimation of the relativistic outflow, and the properties ...

  20. The interplanetary gamma ray burst network

    Science.gov (United States)

    Cline, T.

    The Interplanetary Gamma-Ray Burst Network (IPN) is providing gamma-ray burst (GRB) alerts and localizations at the maximum rate anticipated before the launch of the Swift mission. The arc-minute source precision of the IPN is again permitting searches for GRB afterglows in the radio and optical regimes with delays of only hours up to 2 days. The successful addition of the Mars Odyssey mission has compensated for the loss of the asteroid mission NEAR, to reconstitute a fully long- baseline interplanetary network, with Ulysses at > 5 AU and Konus-Wind and HETE-2 near the Earth. In addition to making unassisted GRB localizations that enable a renewed supply of counterpart observations, the Mars/Ulysses/Wind IPN is confirming and reinforcing GRB source localizations with HETE-2. It has also confirmed and reinforced localizations with the BeppoSAX mission before the BeppoSAX termination in May and has detected and localized both SGRs and an unusual hard x-ray transient that is neither an SGR nor a GRB. This IPN is expected to operate until at least 2004.

  1. Gamma-ray bursts and collisionless shocks

    CERN Document Server

    Waxman, E

    2006-01-01

    Particle acceleration in collisionless shocks is believed to be responsible for the production of cosmic-rays over a wide range of energies, from few GeV to >10^{20} eV, as well as for the non-thermal emission of radiation from a wide variety of high energy astrophysical sources. A theory of collisionless shocks based on first principles does not, however, exist. Observations of gamma-ray burst (GRB) "afterglows" provide a unique opportunity for diagnosing the physics of relativistic collisionless shocks. Most GRBs are believed to be associated with explosions of massive stars, and their "afterglows," delayed low energy emission following the prompt burst of gamma-rays, are produced by relativistic collisionless shock waves driven by the explosion into the surrounding plasma. Some of the striking characteristics of these shocks include the generation of downstream magnetic fields with energy density exceeding that of the upstream field by ~8 orders of magnitude, the survival of this strong field at distances ...

  2. Gamma-Ray Bursts: Should cosmologists care?

    Science.gov (United States)

    Laros, J. G.

    1996-03-01

    Gamma-Ray Burst (GRB) locations are distributed isotropically on the sky, but the intensity distribution of the bursts seems clearly incompatible with spatial homogeneity. Of the scenarios that attempt to provide an explanation, there are two that enjoy current popularity: (1) GRBs are produced by high-velocity neutron stars that have formed an extended (˜100 kpc) spherical halo or “corona” around our galaxy. (2) The bursters are at cosmological distances, with redshifts near unity for the weaker events. The major evidence used to argue for or against each of these scenarios remains inconclusive. Assuming, not unreasonably, that the cosmological scenario is correct, one can discuss the advantages and disadvantages of studying GRBs as opposed to other objects at moderate redshift. We find that the advantages of GRBs-high intensity, penetrating radiation, rapid variability, and no expected source evolution-are offset by observational difficulties pertaining to the extraction of cosmological information from GRB data. If the cosmological scenario proves to be correct and if the observational difficulties are overcome, then cosmologists certainly should care.

  3. $\\gamma$-Ray Bursts the Four Crises

    CERN Document Server

    Tavani, M

    1998-01-01

    We discuss some open problems concerning the origin and the emission mechanism of gamma-ray bursts (GRBs) in light of recent developments. If GRBs originate at extragalactic distances, we are facing four crises: (1) an energy crisis, models have to account for more than 10^{53} ergs of energy emitted in the gamma-ray energy band; (2) a spectral crisis, emission models have to account for the surprising `smoothness' of GRB broad-band spectra, with no indication of the predicted spectral `distorsions' caused by inverse Compton scattering in large radiation energy density media, and no evidence for beaming; (3) an afterglow crisis, relativistic shock models have to explain the complexity of the afterglow behavior, the longevity of optical transients detectable up to six months after the burst, the erratic behavior of the radio emission, and the lack of evidence for substantial beaming as indicated by recent searches for GRB afterglows in the X-ray band; (4) a population crisis, from data clearly indicating that ...

  4. Swift observations of gamma-ray bursts.

    Science.gov (United States)

    Gehrels, Neil

    2007-05-15

    Since its launch on 20 November 2004, the Swift mission has been detecting approximately 100 gamma-ray bursts (GRBs) each year, and immediately (within approx. 90s) starting simultaneous X-ray and UV/optical observations of the afterglow. It has already collected an impressive database, including prompt emission to higher sensitivities than BATSE, uniform monitoring of afterglows and a rapid follow-up by other observatories notified through the GCN. Advances in our understanding of short GRBs have been spectacular. The detection of X-ray afterglows has led to accurate localizations and the conclusion that short GRBs can occur in non-star-forming galaxies or regions, whereas long GRBs are strongly concentrated within the star-forming regions. This is consistent with the NS merger model. Swift has greatly increased the redshift range of GRB detection. The highest redshift GRBs, at z approximately 5-6, are approaching the era of reionization. Ground-based deep optical spectroscopy of high redshift bursts is giving metallicity measurements and other information on the source environment to a much greater distance than other techniques. The localization of GRB 060218 to a nearby galaxy, and the association with SN 2006aj, added a valuable member to the class of GRBs with detected supernova.

  5. Quantitative calculation for the dissipated energy of fault rock burst based on gradient-dependent plasticity

    Institute of Scientific and Technical Information of China (English)

    Xuebin Wang; Shuhong Dai; Long Hai

    2004-01-01

    The capacity of energy absorption by fault bands after rock burst was calculated quantitatively according to shear stressshear deformation curves considering the interactions and interplaying among microstructures due to the heterogeneity of strain softening rock materials. The post-peak stiffness of rock specimens subjected to direct shear was derived strictly based on gradientdependent plasticity, which can not be obtained from the classical elastoplastic theory. Analytical solutions for the dissipated energy of rock burst were proposed whether the slope of the post-peak shear stress-shear deformation curve is positive or not. The analytical solutions show that shear stress level, confining pressure, shear strength, brittleness, strain rate and heterogeneity of rock materials have important influence on the dissipated energy. The larger value of the dissipated energy means that the capacity of energy dissipation in the form of shear bands is superior and a lower magnitude of rock burst is expected under the condition of the same work done by external shear force. The possibility of rock burst is reduced for a lower softening modulus or a larger thickness of shear bands.

  6. Probing the Nature of Short Swift Bursts via Deep INTEGRAL Monitoring of GRB 050925

    Science.gov (United States)

    Sakamoto, T.; Barbier, L.; Barthelmy, S. D.; Cummings, J. R.; Fenimore, E. E.; Gehrels, N.; Krimm, H. A.; Markwardt, C. B.; Palmer, D. M.; Parsons, A. M.; Sato, G.; Stamatikos, M.; Tueller, J.

    2010-01-01

    We present results from Swift, XMM-Newton, and deep INTEGRAL monitoring in the region of GRB 050925. This short Swift burst is a candidate for a newly discovered soft gamma-ray repeater (SGR) with the following observational burst properties: 1) galactic plane (b=-0.1 deg) localization, 2) 150 msec duration, and 3) a blackbody rather than a simple power-law spectral shape (with a significance level of 97%). We found two possible X-ray counterparts of GRB 050925 by comparing the X-ray images from Swift XRT and XMM-Newton. Both X-ray sources show the transient behavior with a power-law decay index shallower than -1. We found no hard X-ray emission nor any additional burst from the location of GRB 050925 in approximately 5 Ms of INTEGRAL data. We discuss about the three BATSE short bursts which might be associated with GRB 050925, based on their location and the duration. Assuming GRB 050925 is associated with the H(sub II), regions (W 58) at the galactic longitude of 1=70 deg, we also discuss the source frame properties of GRB 050925.

  7. The Post-Burst Awakening of the Anomalous X-ray Pulsar in Westerlund 1

    CERN Document Server

    Israel, G L; Dall'Osso, S; Muno, M P; Cummings, J; Perna, R; Stella, L

    2007-01-01

    On September 21, 2006, an intense (~10^39 erg/s) and short (20 ms) burst was detected by Swift BAT at a position consistent with that of the candidate Anomalous X-ray Pulsar, CXOU J164710.2-455216, discovered by Chandra in 2005. Swift follow-up observations began about 13 hours after the event and found the source at a 1-10keV flux level of about 4.5 x 10^-11 erg/s/cm^2, i.e. ~300 times brighter than measured 5 days earlier by XMM. We report the results obtained from Swift BAT observations of the burst and subsequent Swift XRT observations carried out during the first four months after the burst. These data are complemented with those from two XMM observations (carried out just before and after the BAT event) and four archival Chandra observations carried out between 2005 and 2007. We find a phase coherent solution for the source pulsations after the burst. The evolution of the pulse phase comprises an exponential component decaying with timescale of 1.4d which we interpret as the recovery stage following a l...

  8. CRITICAL HYDROLOGIC CONDITIONS FOR OVERFLOW BURST OF MORAINE LAKE

    Institute of Scientific and Technical Information of China (English)

    JIANG Zhong-xin; CUI Peng; JIANG Liang-wei

    2004-01-01

    Floodwater and debris flow caused by glacial lake burst is an important land process and a serious mountain disaster in glacial area of Xizang (Tibet) Autonomous Region, and the overflow burst is mainly caused by glacial landslide falling into moraine lake. On the premise that moraine lake is full, instantaneous burst in part of the lake bank happens, as flow velocity at burst mouth caused by overflow head is higher than threshold flow velocity of glacial till. Under some supposes, d90 and d10 of the glacial till in the bank were used as the threshold sizes of coarse and fine grains respectively. Thus, the formula of calculating threshold flow velocity of uniform sand was simplified,and threshold flow velocity of glacial till was calculated with the formula. Then, with synthesis formula calculating flow velocity of instantaneous part burst, flow velocity at overflow burst mouth was calculated, and calculation formula of critical height (H0) of overflow head was derived. Overflow head was caused by volume and surge of glacial landslide falling into moraine lake, calculation formulas of ascendant height (H1) of lake water surface and surge height (H2) on burst mouth caused by glacial landslide falling into moraine lake were derived. To sum up, critical hydrologic conditions of moraine lake burst with overflow form are: the burst is inevitable as H1 >H0; the burst is possible as H1 <H0 and (H1+H2) >H0; the burst is impossible as (H1+H2) <H0. In the factors influencing the burst critical conditions, it is advantageous for the burst that scale of the lake is 105n2 range; terminal glacial till is more fine and is even more uniform; the width of overflow mouth is even smaller than the length of the bank; the landslide haslarge scale and steep slip surface; and glacial end is close to the lake. With burst of Guangxiecuo Lake in Midui Valley of the Polongzanghu River in Xizang as an example, the burst critical conditions were tested.

  9. Manual evaluation of residual curarization using double burst stimulation

    DEFF Research Database (Denmark)

    Drenck, N E; Ueda, N; Olsen, Niels Vidiendal;

    1989-01-01

    Double burst stimulation (DBS) is a new mode of stimulation developed to reveal residual neuromuscular blockade under clinical conditions. The stimulus consists of two short bursts of 50 Hz tetanic stimulation, separated by 750 ms, and the response to the stimulation is two short muscle contracti...

  10. Gamma-ray bursts observed by the watch experiment

    DEFF Research Database (Denmark)

    Lund, Niels; Brandt, Søren; Castro-Tirado, A. J.

    1991-01-01

    After two years in orbit the WATCH instruments on the GRANAT space observatory have localized seven gamma burst sources with better than 1° accuracy. In several cases, follow‐up observations with Schmidt telescopes have been made within a few days. Some of the bursts have also been detected...

  11. Gamma ray bursts observed with WATCH‐EURECA

    DEFF Research Database (Denmark)

    Brandt, Søren; Lund, Niels; Castro-Tirado, A. J.

    1994-01-01

    The WATCH wide field x‐ray monitor has the capability of independently locating bright Gamma Ray Bursts to 1° accuracy. We report the preliminary positions of 12 Gamma Ray Bursts observed with the WATCH monitor flown on the ES spacecraft EURECA during its 11 month mission. Also the recurrence...... of the Soft Gamma Repeater SGR 1900+14 in 1992 is verified....

  12. Dependence of X-ray Burst Models on Nuclear Masses

    CERN Document Server

    Schatz, H

    2016-01-01

    X-ray burst model predictions of light curves and final composition of the nuclear ashes are affected by uncertain nuclear physics. Nuclear masses play an important role. Significant progress has been made in measuring the masses of very neutron deficient rare isotopes along the path of the rapid proton capture process (rp-process) in X-ray bursts. This paper identifies the remaining nuclear mass uncertainties in X-ray burst models using a one zone model that takes into account the changes in temperature and density evolution caused by changes in the nuclear physics. Two types of bursts are investigated - a typical mixed H/He burst with a limited rp-process and an extreme mixed H/He burst with an extended rp-process. Only three remaining nuclear mass uncertainties affect the light curve predictions of a typical H/He burst, and only three additional masses affect the composition strongly. A larger number of mass uncertainties remains to be addressed for the extreme H/He burst. Mass uncertainties of better than...

  13. Statistical properties of SGR 1806-20 bursts

    NARCIS (Netherlands)

    Göğüş, E.; Woods, P.M.; Kouveliotou, C.; van Paradijs, J.; Briggs, M.S.; Duncan, R.C.; Thompson, C.

    2000-01-01

    We present statistics of SGR 1806-20 bursts, combining 290 events detected with the Rossi X-Ray Timing Explorer/Proportional Counter Array, 111 events detected with the Burst and Transient Source Experiment, and 134 events detected with the International Cometary Explorer. We find that the fluence d

  14. Supernova sheds light on gamma-ray bursts

    CERN Multimedia

    2003-01-01

    On 29 March the HETE-II satellite detected the most violent explosion in the universe to date - an enormous burst of gamma rays. Observers across the world recorded and studied the event. It appears to prove that gamma ray bursts originate in supernovae (1 page)

  15. The INTEGRAL view of intermediate long X-ray bursts

    DEFF Research Database (Denmark)

    CONCLUSIONS Most intermediate bursts are observed from low luminosity sources and are interpreted as long pure He bursts. If no H is accreted, they are consistent with the burning of a slowly accreted, thick He layer, in Ultra Compact X-ray Binaries (UCXB) where the donor star is probably a degen...

  16. Jet simulations and gamma-ray burst afterglow jet breaks

    NARCIS (Netherlands)

    van Eerten, H. J.; Meliani, Z.; Wijers, R.A.M.J.; Keppens, R.

    2010-01-01

    The conventional derivation of the gamma-ray burst afterglow jet break time uses only the blast wave fluid Lorentz factor and therefore leads to an achromatic break. We show that in general gamma-ray burst afterglow jet breaks are chromatic across the self-absorption break. Depending on circumstance

  17. Jet simulations and gamma-ray burst afterglow jet breaks

    NARCIS (Netherlands)

    van Eerten, H. J.; Meliani, Z.; Wijers, Ramj; Keppens, R.

    2011-01-01

    The conventional derivation of the gamma-ray burst afterglow jet break time uses only the blast wave fluid Lorentz factor and therefore leads to an achromatic break. We show that in general gamma-ray burst afterglow jet breaks are chromatic across the self-absorption break. Depending on circumstance

  18. Jet simulations and gamma-ray burst afterglow jet breaks

    NARCIS (Netherlands)

    van Eerten, H.J.; Meliani, Z.; Wijers, R.A.M.J.; Keppens, R.

    2012-01-01

    The conventional derivation of the gamma-ray burst afterglow jet break time uses only the blast wave fluid Lorentz factor and therefore leads to an achromatic break. We show that in general gamma-ray burst afterglow jet breaks are chromatic across the self-absorption break. Depending on circumstance

  19. 76 FR 28460 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Rock Burst...

    Science.gov (United States)

    2011-05-17

    ...; Rock Burst Control Plan--Pertains to Underground Metal and Nonmetal Mines ACTION: Notice. SUMMARY: The... rock burst plan within 90 days after a rock burst has been experienced. Stress data are...

  20. Do Gamma-Ray Bursts Come from the Oort Cloud?

    CERN Document Server

    Clarke, T E; Tremaine, S; Tremaine, adn S.

    1993-01-01

    We examine the possibility that gamma-ray bursts arise from sources in the Oort comet cloud, basing most of our arguments on accepted models for the formation and spatial distribution of the cloud. We identify three severe problems with such models: (1) There is no known mechanism for producing bursts that can explain the observed burst rate and energetics without violating other observational constraints. (2) The bright source counts cannot be reconciled with standard models for the phase-space distribution of objects in the Oort cloud. (3) The observed isotropy of the available burst data is inconsistent with the expected angular distribution of sources in the Oort cloud. We therefore assert that Oort cloud models of gamma-ray bursts are extremely implausible.

  1. Ablation of silicon with bursts of femtosecond laser pulses

    Science.gov (United States)

    Gaudiuso, Caterina; Kämmer, Helena; Dreisow, Felix; Ancona, Antonio; Tünnermann, Andreas; Nolte, Stefan

    2016-03-01

    We report on an experimental investigation of ultrafast laser ablation of silicon with bursts of pulses. The pristine 1030nm-wavelength 200-fs pulses were split into bursts of up to 16 sub-pulses with time separation ranging from 0.5ps to 4080ps. The total ablation threshold fluence was measured depending on the burst features, finding that it strongly increases with the number of sub-pulses for longer sub-pulse delays, while a slowly increasing trend is observed for shorter separation time. The ablation depth per burst follows two different trends according to the time separation between the sub-pulses, as well as the total threshold fluence. For delays shorter than 4ps it decreases with the number of pulses, while for time separations longer than 510ps, deeper craters were achieved by increasing the number of subpulses in the burst, probably due to a change of the effective penetration depth.

  2. Cosmology and the Subgroups of Gamma-ray Bursts

    Directory of Open Access Journals (Sweden)

    A. Mészáros

    2011-01-01

    Full Text Available Both short and intermediate gamma-ray bursts are distributed anisotropically in the sky (Mészáros, A. et al. ApJ, 539, 98 (2000, Vavrek, R. et al. MNRAS, 391, 1 741 (2008. Hence, in the redshift range, where these bursts take place, the cosmological principle is in doubt. It has already been noted that short bursts should be mainly at redshifts smaller than one (Mészáros, A. et al. Gamma-ray burst: Sixth Huntsville Symp., AIP, Vol. 1 133, 483 (2009; Mészáros, A. et al. Baltic Astron., 18, 293 (2009. Here we show that intermediate bursts should be at redshifts up to three.

  3. Kilometric shock-associated events and microwave bursts

    Science.gov (United States)

    Kundu, M. R.; Macdowall, R. J.; Stone, R. G.

    1990-01-01

    The peak times of impulsive microwaves bursts are compared with those of shock-associated (SA) kilometric radio events. The first peaks in these two frequency regimes are usually well-correlated in time, but the last peaks of the SA events observed at 1 MHz occur an average of 20 min after the last impulsive microwave peaks. In some cases, the SA events overlap in time with the post-burst increases of microwave bursts; sometimes there is general correspondence in their intensity time profiles. These observations suggest that the earlier components of the SA events are usually caused by electrons accelerated in or near the microwave source region. The possibility that the later components of some SA events could be associated with nonthermal electrons responsible for microwave post-burst increases, although they have traditionally been attributed to electrons accelerated at type II burst producing shocks in the upper corona is discussed.

  4. The supernova-gamma-ray burst-jet connection.

    Science.gov (United States)

    Hjorth, Jens

    2013-06-13

    The observed association between supernovae and gamma-ray bursts represents a cornerstone in our understanding of the nature of gamma-ray bursts. The collapsar model provides a theoretical framework for this connection. A key element is the launch of a bipolar jet (seen as a gamma-ray burst). The resulting hot cocoon disrupts the star, whereas the (56)Ni produced gives rise to radioactive heating of the ejecta, seen as a supernova. In this discussion paper, I summarize the observational status of the supernova-gamma-ray burst connection in the context of the 'engine' picture of jet-driven supernovae and highlight SN 2012bz/GRB 120422A--with its luminous supernova but intermediate high-energy luminosity--as a possible transition object between low-luminosity and jet gamma-ray bursts. The jet channel for supernova explosions may provide new insights into supernova explosions in general.

  5. High-Frequency Cutoff in Type III Bursts

    Science.gov (United States)

    Stanislavsky, A. A.; Konovalenko, A. A.; Volvach, Ya. S.; Koval, A. A.

    In this article we report about a group of solar bursts with high-frequency cutoff, observed on 19 August of 2012 near 8:23 UT, simultaneously by three different radio telescopes: the Ukrainian decameter radio telescope (8-33 MHz), the French Nancay Decametric Array (10-70 MHz) and the Italian San Vito Solar Observatory of RSTN (25-180 MHz). Morphologically the bursts are very similar to the type III bursts. The solar activity is connected with the emergency of a new group of solar spots on the far side of the Sun with respect to observers on Earth. The solar bursts accompany many moderate flares over eastern limb. The refraction of the behind-limb radio bursts towards the Earth is favorable, if CMEs generate low-density cavities in solar corona.

  6. Fast Radio Bursts: Constraints on the Dispersing Medium

    CERN Document Server

    Dennison, Brian

    2014-01-01

    Fast radio bursts appear to exhibit large dispersion measures, typically exceeding any expected galactic interstellar contribution, especially along the moderate to high-galactic-latitude directions in which such events have been most often observed. The dispersions have been therefore interpreted as extragalactic, leading to the inference that the sources of the bursts are at Gpc distances. This then implies that the bursts are extremely energetic events, originating from quite small volumes (due to the millisecond burst durations). To circumvent the energetic difficulties, Loeb, Shvartzvald, & Maoz (2014) propose that the bursts are produced by flares near the surfaces of M stars or contact binaries within a local volume of the galaxy. Most of the dispersion would then occur in the overlying stellar coronae. With the dispersion concentrated in a relatively high density region, the quadratic dispersion approximation breaks down as the plasma frequency is comparable to (although less than) the propagation...

  7. X-ray bursts and superbursts - recent developments

    CERN Document Server

    Zand, Jean in 't

    2011-01-01

    The past decade and a half has seen many interesting new developments in X-ray burst research, both observationally and theoretically. New phenomena were discovered, such as burst oscillations and superbursts, and new regimes of thermonuclear burning identified. An important driver of the research with present and future instrumentation in the coming years is the pursuit of fundamental neutron star parameters. However, several other more direct questions are also in dire need of an answer. For instance, how are superbursts ignited and why do burst oscillations exist in burst tails? We briefly review recent developments and discuss the role that MAXI can play. Thanks to MAXI's large visibility window and large duty cycle, it is particularly well suited to investigate the recurrence of rare long duration bursts such as superbursts. An exploratory study of MAXI data is briefly presented.

  8. Review of GRANAT observations of gamma-ray bursts

    DEFF Research Database (Denmark)

    Terekhov, O.; Denissenko, D.; Sunyaev, R.;

    1995-01-01

    The GRANAT observatory was launched into a high apogee orbit on 1 December, 1989. Three instruments onboard GRANAT - PHEBUS, WATCH and SIGMA are able to detect gamma-ray bursts in a very broad energy range from 6 keV up to 100 MeV. Over 250 gamma-ray bursts were detected. We discuss the results...... of four differently behaving componenents in gamma-ray burst spectra is discussed. Statistical properties of the gamma-ray burst sources based on the 5 years of observations with (∼ 10−6 erg/cm2) sensitivity as well as the results of high sensitivity (∼ 10−8 erg/cm2) search for Gamma-Ray Bursts within...... the SIGMA telescope field of view are reviewed....

  9. Evaluating the risk of coal bursts in underground coal mines

    Institute of Scientific and Technical Information of China (English)

    Mark Christopher⇑; Gauna Michael

    2016-01-01

    Coal bursts involve the sudden, violent ejection of coal or rock into the mine workings. They are almost always accompanied by a loud noise, like an explosion, and ground vibration. Bursts are a particular haz-ard for miners because they typically occur without warning. Despite decades of research, the sources and mechanics of these events are not well understood, and therefore they are difficult to predict and control. Experience has shown, however, that certain geologic and mining factors are associated with an increased likelihood of a coal burst. A coal burst risk assessment consists of evaluating the degree to which these risk factors are present, and then identifying appropriate control measures to mitigate the hazard. This paper summarizes the U.S. and international experience with coal bursts, and describes the known risk factors in detail. It includes a framework that can be used to guide the risk assessment process.

  10. Taming desynchronized bursting with delays in the Macaque cortical network

    Institute of Scientific and Technical Information of China (English)

    Wang Qing-Yun; Murks Aleksandra; Perc Matja(z); Lu Qi-Shao

    2011-01-01

    Inhibitory coupled bursting Hindmarsh-Rose neurons are considered as constitutive units of the Macaque cortical network. In the absence of information transmission delay the bursting activity is desynchronized, giving rise to spatiotemporally disordered dynamics. This paper shows that the introduction of finite delays can lead to the synchroization of bursting and thus to the emergence of coherent propagating fronts of excitation in the space-time domain.Moreover, it shows that the type of synchronous bursting is uniquely determined by the delay length, with the transitions from one type to the other occurring in a step-like manner depending on the delay. Interestingly, as the delay is tuned close to the transition points, the synchronization deteriorates, which implies the coexistence of different bursting attractors. These phenomena can be observed be different but fixed coupling strengths, thus indicating a new role for information transmission delays in realistic neuronal networks.

  11. Relation Between Type II Bursts and CMEs Inferred from STEREO Observations

    Science.gov (United States)

    Gopalswamy, N.; Thompson, W.; Davila, J.; Kaiser, M. L.; Yashiro, S.; Maekelae, P.; Michalek, G.; Bougeret, J.-L.; Hoawrd, R. A.

    2010-01-01

    The inner coronagraph (COR1) of the Solar Terrestrial Relations Observatory (STEREO) mission has made it possible to observe coronal mass ejections (CMEs) a in the spatial domain overlapping with that of the metric type II radio bursts. The type II bursts were associated with generally weak flares (mostly B and C class soft X-ray flares), but the CMEs were quite energetic. Using CME data for a set of type II bursts during the declining phase of solar cycle 23, we determine the CME height when the type II bursts start, thus giving an estimate of the heliocentric distance at which CME-driven shocks form. This distance has been determined to be approximately 1.5Rs (solar radii), which coincides with the distance at which the Alfv?n speed profile has a minimum value. We also use type II radio observations from STEREO/WAVES and Wind/WAVES observations to show that CMEs with moderate speed drive either weak shocks or no shock at all when they attain a height where the Alfv?n speed peaks (?3Rs ? 4Rs). Thus the shocks seem to be most efficient in accelerating electrons in the heliocentric distance range of 1.5Rs to 4Rs. By combining the radial variation of the CME speed in the inner corona (CME speed increase) and interplanetary medium (speed decrease) we were able to correctly account for the deviations from the universal drift-rate spectrum of type II bursts, thus confirming the close physical connection between type II bursts and CMEs. The average height (approximately 1.5 Rs) of STEREO CMEs at the time of type II bursts is smaller than that (2.2 Rs) obtained for SOHO (Solar and Heliospheric Observatory) CMEs. We suggest that this may indicate, at least partly, the density reduction in the corona between the maximum and declining phases, so a given plasma level occurs closer to the Sun in the latter phase. In two cases, there was a diffuse shock-like feature ahead of the main body of the CME, indicating a standoff distance of 1Rs - 2Rs by the time the CME left the LASCO

  12. Natural electromagnetic radiation of edge part of seam with rock burst hazard

    Energy Technology Data Exchange (ETDEWEB)

    Proskuryakov, V.M.; Shabarov, A.N.; Frid, V.I. (VNIMI (USSR))

    1989-04-01

    Describes experimental use of measurement of electromagnetic radiation from rocks as a method of forecasting rock burst hazards. The experiments were performed at a Severokuzbassugol' mine using an EG-9 remote recording instrument developed by VNIMI. No boreholes are required; the instrument sensors are situated at 2-10 m intervals along the roadway. The experimental recordings were made in a face entry during hydraulic stress relief treatment of the coal. High levels of electromagnetic radiation correlated with high drill fines yields to indicate a high rock burst hazard level. A hazard zone that was found was rendered safe by drilling 2 sets of 90 mm diameter boreholes fanning out into the zone, first to a depth of 6 m, then to 12 m.

  13. Short Gamma-Ray Bursts with Extended Emission

    Science.gov (United States)

    Norris, J. P.; Bonnell, J. T.

    2005-01-01

    The recent association of several short gamma-ray bursts (GRBs) with early type galaxies with low star formation rate demonstrates that short bursts arise from a different progenitor mechanism than long bursts. However, since the duration distributions of the two classes overlap, membership is not always easily established. The picture is complicated by the occasional presence of softer, extended emission lasting tens of seconds after the initial spike- like emission comprising an otherwise short burst. Using the large BATSE sample with time-tagged event (TTE) data, we show that the fundamental defining characteristic of the short burst class is that the initial spike exhibits negligible spectral evolution at energies above approx. 25 keV. This is behavior is nearly ubiquitous for the 260 bursts with T(sub 90) less than 2s where the BATSE TTE data type completely included the initial spike: Their spectral lags measured between the 25-50 keV and 100-300 energy ranges are consistent with zero in 90-95% of the cases, with most outliers probably representing the tail of the long burst class. We also analyze a small sample of "short" BATSE bursts - those with the most fluent, intense extended emission. The same lack of evolution on the pulse timescale obtains for the extended emission in the brighter bursts where significant measurements can be made. One possible inference is that both emission components may arise in the same region. We also show that the dynamic range in the ratio of peak intensities, spike : extended, is at least approx. l0(exp 3), and that for some bursts, the extended emission is only a factor of 2-5 lower. However, for our whole sample the total counts fluence of the extended component equals or exceeds that in the spike by a factor of several.

  14. A Different Cone: Bursting Drops in Solids

    Science.gov (United States)

    Zhao, Xuanhe

    2013-03-01

    Drops in fluids tend to be spheres--a shape that minimizes surface energy. In thunderstorm clouds, drops can become unstable and emit thin jets when charged beyond certain limits. The instability of electrified drops in gases and liquids has been widely studied and used in applications including ink-jet printing, electrospinning nano-fibers, microfluidics and electrospray ionization. Here we report a different scenario: drops in solids become unstable and burst under sufficiently high electric fields. We find the instability of drops in solids morphologically resembles that in liquids, but the critical electric field for the instability follows a different scaling due to elasticity of solids. Our observations and theoretical models not only advance the fundamental understanding of electrified drops but also suggest a new failure mechanism of high-energy-density dielectric polymers, which have diverse applications ranging from capacitors for power grids and electric vehicles to muscle-like transducers for soft robots and energy harvesting.

  15. The Gamma Ray Bursts Hubble diagram

    CERN Document Server

    Capozziello, S; Dainotti, M G; De Laurentis, M; Izzo, L; Perillo, M

    2011-01-01

    Thanks to their enormous energy release, Gamma Rays Bursts (GRBs) have recently attracted a lot of interest to probe the Hubble diagram (HD) deep into the matter dominated era and hence complement Type Ia Supernovae (SNeIa). We consider here three different calibration methods based on the use of a fiducial LCDM model, on cosmographic parameters and on the local regression on SNeIa to calibrate the scaling relations proposed as an equivalent to the Phillips law to standardize GRBs finding any significant dependence. We then investigate the evolution of these parameters with the redshift to obtain any statistical improvement. Under this assumption, we then consider possible systematics effects on the HDs introduced by the calibration method, the averaging procedure and the homogeneity of the sample arguing against any significant bias.

  16. Search for Gamma Ray Bursts at Chacaltaya

    CERN Document Server

    Vernetto, S

    2001-01-01

    A search for Gamma Ray Bursts in the GeV-TeV energy range has been performed by INCA, an air shower array working at 5200 m of altitude at the Chacaltaya Laboratory (Bolivia). The altitude of the detector and the use of the "single particle technique" allows to lower the energy threshold up to few GeVs. No significant signals are observed during the occurrence of 125 GRBs detected by BATSE, and the obtained upper limits on the energy fluence in the interval 1-1000(100) GeV range from 3.2(8.6) 10^-5 to 2.6(7.0) 10^-2 erg/cm^2 depending on the zenith angle of the events. These limits, thanks to the extreme altitude of INCA, are the lowest ever obtained in the sub-TeV energy region by a ground based esperiment.

  17. Black Holes, Supernovae and Gamma Ray Bursts

    CERN Document Server

    Ruffini, Remo

    2013-01-01

    We review recent progress in our understanding of the nature of gamma ray bursts (GRBs) and in particular, of the relationship between short GRBs and long GRBs. The first example of a short GRB is described. The coincidental occurrence of a GRB with a supernova (SN) is explained within the induced gravitational collapse (IGC) paradigm, following the sequence: 1) an initial binary system consists of a compact carbon-oxygen (CO) core star and a neutron star (NS); 2) the CO core explodes as a SN, and part of the SN ejecta accretes onto the NS which reaches its critical mass and collapses to a black hole (BH) giving rise to a GRB; 3) a new NS is generated by the SN as a remnant. The observational consequences of this scenario are outlined.

  18. Synchrotron masers and fast radio bursts

    CERN Document Server

    Ghisellini, Gabriele

    2016-01-01

    Fast Radio Bursts (FRBs), with a typical duration of 1 ms and 1 Jy flux density at GHz frequencies, have brightness temperatures exceeding 1e33 K, requiring a coherent emission process. This can be achieved by bunching particles in volumes smaller than the typical wavelength, but this may be challenging. Alternatively, we can have maser emission. Under certain conditions, the synchrotron stimulated emission process can be more important than true absorption, and a synchrotron maser can be created. This occurs when the emitting electrons have a very narrow distribution of pitch angles and energies. This process overcomes the difficulties of having extremely dense bunches of particles and relaxes the light crossing time limits, since there is no simple relation between the actual size of the source and the observed variability timescale.

  19. Relativistic Outflows in Gamma-Ray Bursts

    CERN Document Server

    Aloy, M A

    2007-01-01

    The possibility that gamma-ray bursts (GRBs) were not isotropic emissions was devised theoretically as a way to ameliorate the huge energetic budget implied by the standard fireball model for these powerful phenomena. However, the mechanism by which after the quasy-isotropic release of a few $10^{50} $erg yields a collimated ejection of plasma could not be satisfactory explained analytically. The reason being that the collimation of an outflow by its progenitor system depends on a very complex and non-linear dynamics. That has made necessary the use of numerical simulations in order to shed some light on the viability of some likely progenitors of GRBs. In this contribution I will review the most relevant features shown by these numerical simulations and how they have been used to validate the collapsar model (for long GRBs) and the model involving the merger of compact binaries (for short GRBs).

  20. Microstructural path analysis of martensite burst

    Directory of Open Access Journals (Sweden)

    Paulo Rangel Rios

    2010-03-01

    Full Text Available Modeling the martensite reaction requires reckoning with spatial aspects of the reaction. For that, we used formal kinetics, more specifically, the microstructural path method (MPM to analyze the microstructure observed in a burst. The microstructural path analysis revealed that the size of the spread cluster in extended space, characterized by the Vandermeer and Juul-Jensen's impingement compensated mean intercept length, λG, remained constant, independently of the parent austenite grain size. Moreover, current analysis introduced a purely formal description of the reaction progress by taking the parent austenite grain size as the progress variable. This description worked very well and resulted in a relationship between the volume fraction of partially transformed austenite, V VG, and austenite grain size, λG. The significance of these findings in the light of the advantages and disadvantages of formal kinetics is discussed.

  1. Critical Test Of Gamma Ray Burst Theories

    CERN Document Server

    Dado, Shlomo

    2016-01-01

    Long and precise follow-up measurements of the X-ray afterglow (AG) of very intense gamma ray bursts (GRBs) provide a critical test of GRB afterglow theories. Here we show that the power-law decline with time of X-ray AG of GRB 130427A, the longest measured X-ray AG of an intense GRB with the Swift, Chandra and XMM Newton satellites, and of all other well measured late-time X-ray afterglow of intense GRBs, is that predicted by the cannonball (CB) model of GRBs from their measured spectral index, while it disagrees with that predicted by the widely accepted fireball (FB) models of GRBs.

  2. Synchrotron masers and fast radio bursts

    Science.gov (United States)

    Ghisellini, G.

    2017-02-01

    Fast radio bursts, with a typical duration of 1 ms and 1 Jy flux density at gigahertz frequencies, have brightness temperatures exceeding 1033 K, requiring a coherent emission process. This can be achieved by bunching particles in volumes smaller than the typical wavelength, but this may be challenging. Maser emission is a possibility. Under certain conditions, the synchrotron-stimulated emission process can be more important than true absorption, and a synchrotron maser can be created. This occurs when the emitting electrons have a very narrow distribution of pitch angles and energies. This process overcomes the difficulties of having extremely dense bunches of particles and relaxes the light-crossing time limits, since there is no simple relation between the actual size of the source and the observed variability time-scale.

  3. Gamma-ray burst afterglow theory

    CERN Document Server

    van Eerten, Hendrik

    2013-01-01

    It is by now fairly well established that gamma-ray burst afterglows result from initially relativistic outflows interacting with the medium surrounding the burster and emitting non-thermal radiation ranging from radio to X-rays. However, beyond that, many big and small questions remain about afterglows, with the accumulating amount of observational data at the various frequencies raising as many questions as they answer. In this review I highlight a number of current theoretical issues and how they fit or do not fit within our basic theoretical framework. In addition to theoretical progress I will also emphasize the increasing role and usefulness of numerical studies of afterglow blast waves and their radiation.

  4. Gamma ray bursts and their afterglows

    Science.gov (United States)

    Nicuesa Guelbenzu, A.

    2017-03-01

    Gamma-Ray Bursts (GRBs) were among the greatest mysteries in modern astrophysics. They were first observed 50 years ago but it took three decades before optical counterparts could be found and the underlying physical phenomena studied in detail. GRB research represents currently one of the most rapidly growing areas in extragalactic astronomy. This is due in large part to the numerous connections that GRBs have with other disciplines like cosmology, supernovae, stellar evolution, nuclear physics, astroparticle and gravitational wave astronomy. Therefore, their study is of great importance to understand various astrophysical phenomena such as the formation of the first stars, the chemical evolution and the expansion of the Universe. Since gamma radiation can travel along cosmological distances without being affected by any possible intervening absorption, GRBs can be detected from the most distant universe, reaching redshifts up to z = 10 or more.

  5. Monitoring burst (M-burst) — A novel framework of failure localization in all-optical mesh networks

    KAUST Repository

    Ali, Mohammed L.

    2011-10-10

    Achieving instantaneous and precise failure localization in all-optical wavelength division multiplexing (WDM) networks has been an attractive feature of network fault management systems, and is particularly important when failure-dependent protection is employed. The paper introduces a novel framework of real-time failure localization in all-optical WDM mesh networks, called monitoring-burst (m-burst), which aims to initiate a graceful compromise between consumed monitoring resources and monitoring delay. Different from any previously reported solution, the proposed m-burst framework has a single monitoring node (MN) which launches optical bursts along a set of pre-defined close-loop routes, called monitoring cycles (m-cycles), to probe the links along the m-cycles. Bursts along different m-cycles are kept non-overlapping through any link of the network. By identifying the lost bursts due to single link failure events only, the MN can unambiguously localize the failed link in at least 3-connected networks. We will justify the feasibility and applicability of the proposed m-burst framework in the scenario of interest. To avoid possible collision among optical bursts launched by the MN, we define the problem of collision-free scheduling and formulate it into an integer linear program (ILP) in order to minimize the monitoring delay. Numerical results demonstrate the effectiveness of the proposed framework and the proposed solution.

  6. Does Twitter trigger bursts in signature collections?

    Directory of Open Access Journals (Sweden)

    Rui Yamaguchi

    Full Text Available INTRODUCTION: The quantification of social media impacts on societal and political events is a difficult undertaking. The Japanese Society of Oriental Medicine started a signature-collecting campaign to oppose a medical policy of the Government Revitalization Unit to exclude a traditional Japanese medicine, "Kampo," from the public insurance system. The signature count showed a series of aberrant bursts from November 26 to 29, 2009. In the same interval, the number of messages on Twitter including the keywords "Signature" and "Kampo," increased abruptly. Moreover, the number of messages on an Internet forum that discussed the policy and called for signatures showed a train of spikes. METHODS AND FINDINGS: In order to estimate the contributions of social media, we developed a statistical model with state-space modeling framework that distinguishes the contributions of multiple social media in time-series of collected public opinions. We applied the model to the time-series of signature counts of the campaign and quantified contributions of two social media, i.e., Twitter and an Internet forum, by the estimation. We found that a considerable portion (78% of the signatures was affected from either of the social media throughout the campaign and the Twitter effect (26% was smaller than the Forum effect (52% in total, although Twitter probably triggered the initial two bursts of signatures. Comparisons of the estimated profiles of the both effects suggested distinctions between the social media in terms of sustainable impact of messages or tweets. Twitter shows messages on various topics on a time-line; newer messages push out older ones. Twitter may diminish the impact of messages that are tweeted intermittently. CONCLUSIONS: The quantification of social media impacts is beneficial to better understand people's tendency and may promote developing strategies to engage public opinions effectively. Our proposed method is a promising tool to explore

  7. Explosion suppression system

    Science.gov (United States)

    Sapko, Michael J.; Cortese, Robert A.

    1992-01-01

    An explosion suppression system and triggering apparatus therefor are provided for quenching gas and dust explosions. An electrically actuated suppression mechanism which dispenses an extinguishing agent into the path ahead of the propagating flame is actuated by a triggering device which is light powered. This triggering device is located upstream of the propagating flame and converts light from the flame to an electrical actuation signal. A pressure arming device electrically connects the triggering device to the suppression device only when the explosion is sensed by a further characteristic thereof beside the flame such as the pioneer pressure wave. The light powered triggering device includes a solar panel which is disposed in the path of the explosion and oriented between horizontally downward and vertical. Testing mechanisms are also preferably provided to test the operation of the solar panel and detonator as well as the pressure arming mechanism.

  8. In vitro reinforcement of hippocampal bursting: a search for Skinner's atoms of behavior.

    OpenAIRE

    Stein, L; Xue, B G; Belluzzi, J D

    1994-01-01

    A novel "in vitro reinforcement" paradigm was used to investigate Skinner's (1953) hypotheses (a) that operant behavior is made up of infinitesimal "response elements" or "behavioral atoms" and (b) that these very small units, and not whole responses, are the functional units of reinforcement. Our tests are based on the assumption that behavioral atoms may plausibly be represented at the neural level by individual cellular responses. As a first approach, we attempted to reinforce the bursting...

  9. Cosmic radio-noise absorption bursts caused by solar wind shocks

    OpenAIRE

    Osepian, A.; S. Kirkwood

    2004-01-01

    Bursts of cosmic noise absorption observed at times of sudden commencements (SC) of geomagnetic storms are examined. About 300SC events in absorption for the period 1967-1990 have been considered. It is found that the response of cosmic radio-noise absorption to the passage of an interplanetary shock depends on the level of the planetary magnetic activity preceding the SC event and on the magnitude of the magnetic field perturbation associated with the SC (as measured in the equatorial magnet...

  10. Suppression subtractive hybridization (SSH)-based method for estimating Cd-induced differences in gene expression at cultivar level and identification of genes induced by Cd in two water spinach cultivars.

    Science.gov (United States)

    Huang, Baifei; Xin, Junliang; Yang, Zhongyi; Zhou, Yihui; Yuan, Jiangang; Gong, Yulian

    2009-10-14

    The abilities to accumulate cadmium (Cd) are different among cultivars (cv.) in many species. The characteristic of Cd concentration among cultivars is heritable and is probably controlled by genes, but rather limited information about the relevant genes in vegetable crops has been published. In the present study, a suppression subtractive hybridization (SSH) approach was used to identify genes induced by Cd in two water spinach (an important vegetable in southern China) cultivars that differ in Cd accumulation in their edible parts. The two cultivars were cv. Qiangkunqinggu (QK), a low Cd accumulative cultivar and cv. Taiwan 308 (TW), a high Cd accumulative cultivar. In the construction of QK and TW libraries, the plants without Cd treatment were taken as drivers and the plants exposed to 6 mg L(-1) Cd for 24 h as testers. Four hundred clones were sequenced, and 164 nonrepeated sequences (112 from the QK library and 52 from the TW library) were assigned to being functional genes or proteins. A tremendous difference in Cd-induced gene expressions between the two libraries was observed. In the QK library, genes implicated in disease/defense comprised one of the largest sets (20.6%), whereas the proportion was only 8.8% in the TW library. An MT3 gene (Q5), a wound inductive gene (Q22), an antioxidation relevant gene (Q34), a lectin gene (Q45), an f-box family protein gene (Q319), a 20S proteasome subunit gene (T17), a multidrug resistance associated protein gene (T156), and a cationic amino acid transporter gene (T218) were selected to compare semiquantitatively their expression between cv. QK and cv. TW using the RT-PCR method, and obvious differences were detected. The relationships between the identified differences in the expressions of the genes and the Cd accumulation of the two cultivars were discussed, and it was concluded that the SSH approach is useful for finding the difference in expression of Cd-induced gene even at the cultivar level and is applicable

  11. Radio fiber bursts and fast magnetoacoustic wave trains

    CERN Document Server

    Karlický, M; Jelínek, P

    2012-01-01

    We present a model for dm-fiber bursts that is based on assuming fast sausage magnetoacoustic wave trains that propagate along a dense vertical filament or current sheet. Eight groups of dm-fiber bursts that were observed during solar flares were selected and analyzed by the wavelet analysis method. To model these fiber bursts we built a semi-empirical model. We also did magnetohydrodynamic simulations of a propagation of the magnetoacoustic wave train in a vertical and gravitationally stratified current sheet. In the wavelet spectra of the fiber bursts computed at different radio frequencies we found the wavelet tadpoles, whose head maxima have the same frequency drift as the drift of fiber bursts. It indicates that the drift of these fiber bursts can be explained by the propagating fast sausage magnetoacoustic wave train. Using new semi-empirical and magnetohydrodynamic models with a simple radio emission model we generated the artificial radio spectra of the fiber bursts, which are similar to the observed ...

  12. Unusual Solar Radio Burst Observed at Decameter Wavelengths

    Science.gov (United States)

    Melnik, V. N.; Brazhenko, A. I.; Konovalenko, A. A.; Rucker, H. O.; Frantsuzenko, A. V.; Dorovskyy, V. V.; Panchenko, M.; Stanislavskyy, A. A.

    2014-01-01

    An unusual solar burst was observed simultaneously by two decameter radio telescopes UTR-2 (Kharkov, Ukraine) and URAN-2 (Poltava, Ukraine) on 3 June 2011 in the frequency range of 16 - 28 MHz. The observed radio burst had some unusual properties, which are not typical for the other types of solar radio bursts. Its frequency drift rate was positive (about 500 kHz s-1) at frequencies higher than 22 MHz and negative (100 kHz s-1) at lower frequencies. The full duration of this event varied from 50 s up to 80 s, depending on the frequency. The maximum radio flux of the unusual burst reached ≈103 s.f.u. and its polarization did not exceed 10 %. This burst had a fine frequency-time structure of unusual appearance. It consisted of stripes with the frequency bandwidth 300 - 400 kHz. We consider that several accompanied radio and optical events observed by SOHO and STEREO spacecraft were possibly associated with the reported radio burst. A model that may interpret the observed unusual solar radio burst is proposed.

  13. Short Gamma-Ray Bursts with Extended Emission

    CERN Document Server

    Norris, J P; Bonnell, Jerry T.; Norris, Jay P.

    2006-01-01

    The recent association of several short gamma-ray bursts (GRBs) with early type galaxies with low star formation rate demonstrates that short bursts arise from a different progenitor mechanism than long bursts. However, since the duration distributions of the two classes overlap, membership is not always easily established. The picture is complicated by the occasional presence of softer, extended emission lasting tens of seconds after the initial spike-like emission. We show that the fundamental defining characteristic of the short burst class is that the initial spike exhibits negligible spectral evolution at energies above ~ 25 keV. This behavior is nearly ubiquitous for the 260 bursts with T90 < 2 s, where the BATSE TTE data completely included the initial spike. The same signature obtains for one HETE-2 and six Swift/BAT short bursts. Analysis of a small sample of "short" BATSE bursts with the most intense extended emission shows that the same lack of evolution on the pulse timescale obtains for the ex...

  14. Large Aerial Bursts: An Important Class of Terrestrial Accretionary Events

    Science.gov (United States)

    Wasson, John T.

    2003-01-01

    Large aerial bursts similar to the 1908 Tunguska bolide but much larger in magnitude have surely been responsible for many catastrophic events in the history of the Earth. Because aerial bursts produce shallow (or even negligible) craters, their existence is difficult to document in the geological record. Even aerial bursts as small as Tunguska deposit enough energy to melt ~1mm of dry soil. Silica-rich glass formed in such melts has the potential to survive in the soil for many Ma, thus a potential indicator of large aerial bursts is glass that was formed as thick regions within silicate melt sheets. The layered tektites from Southeast Asia and the Libyan desert glass may have formed by a combination of sedimentation and downslope flow of silicate melt heated by radiation from large aerial bursts. The alternative, formation of layered tektites as crater ejecta, cannot account for observations such as uniformly high 10Be contents, the orientation of the magnetic remanence field, and the absence of splash-form (e.g., teardrop or dumbbell) tektites in regions where layered tektites are common. The largest asteroids or comets make craters no matter what their strength. Recent reviews suggest that, for events in the energy range up to 1019-1020 J (about two orders of magnitude larger than the Meteor Crater impact), aerial bursts are more likely than cratering events, and the layered tektites of Southeast Asia imply the existence of aerial bursts one to two orders of magnitude larger still.

  15. Gamma Ray Bursts and the Birth of Black Holes

    Science.gov (United States)

    Gehrels, Neil

    2009-01-01

    Black holes have been predicted since the 1940's from solutions of Einstein's general relativity field equation. There is strong evidence of their existence from astronomical observations, but their origin has remained an open question of great interest. Gamma-ray bursts may the clue. They are powerful explosions, visible to high redshift, and appear to be the birth cries of black holes. The Swift and Fermi missions are two powerful NASA observatories currently in orbit that are discovering how gamma-ray bursts work. Evidence is building that the long and short duration subcategories of GRBs have very different origins: massive star core collapse to a black hole for long bursts and binary neutron star coalescence to a black hole for short bursts. The similarity to Type II and Ia supernovae originating from young and old stellar progenitors is striking. Bursts are tremendously luminous and are providing a new tool to study the high redshift universe. One Swift burst at z=8.3 is the most distant object known in the universe. The talk will present the latest gamma-ray burst results from Swift and Fermi and will highlight what they are teaching us about black holes and jet outflows.

  16. On the Galactic Distribution of Gamma Ray Bursts

    CERN Document Server

    Lewin, W H G; Lewin, Robert E. Rutledge \\& Walter H.G.

    1993-01-01

    Quashnock and Lamb (1993) defined a sub-sample of Gamma-ray Bursts (GRBs) from the publicly available BATSE database which shows clumping toward the galactic plane, and concluded that all GRBs are galactic in origin. The selection of these bursts (duplicated in this work in Sample 1) involved a peak countrate (in counts s-1) uncorrected for aspect. We assert that the peak flux of a burst is physically more meaningful than peak count-rate. Using, as limits, the corresponding peak fluxes (in photons cm-2 s-1) for the bursts in the QL sample, we find an additional 24 bursts, which we include in a new sample (Sample 2). We find that the significance of anisotropy in Sample 2 is much less than that of Sample 1, which does not support QL's interpretation of the anisotropies as being due to a galactic population. To make meaningful statistical statements regarding isotropy, burst samples must have peak fluxes above a minimum flux, set by the requirement that a burst be detectable from any direction (above the horizo...

  17. Possible hard X-ray shortages in bursts from KS 1731-260 and 4U 1705-44

    CERN Document Server

    Ji, Long; Chen, YuPeng; Zhang, Shuang-Nan; Kretschmar, Peter; Wang, Jian-Min; Li, Jian

    2014-01-01

    Aims: A hard X-ray shortage, implying the cooling of the corona, was observed during bursts of IGR J17473-272, 4U 1636-536, Aql X-1, and GS 1826-238. Apart from these four sources, we investigate here an atoll sample, in which the number of bursts for each source is larger than 5, to explore the possible additional hard X-ray shortage during {\\it Rossi X-ray timing explorer (RXTE)} era. Methods: According to the source catalog that shows type-I bursts, we analyzed all the available pointing observations of these sources carried out by the {\\it RXTE} proportional counter array (PCA). We grouped and combined the bursts according to their outburst states and searched for the possible hard X-ray shortage while bursting. Results: We found that the island states of KS 1731-260 and 4U 1705-44 show a hard X-ray shortage at significant levels of 4.5 and 4.7 $\\sigma$ and a systematic time lag of $0.9 \\pm 2.1$ s and $2.5 \\pm 2.0$ s with respect to the soft X-rays, respectively. While in their banana branches and other s...

  18. BROADBAND SPECTRAL INVESTIGATIONS OF SGR J1550-5418 BURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Lin Lin; Goegues, Ersin; Kaneko, Yuki [Faculty of Engineering and Natural Sciences, Sabanc Latin-Small-Letter-Dotless-I University, Orhanl Latin-Small-Letter-Dotless-I Tuzla, Istanbul 34956 (Turkey); Baring, Matthew G. [Department of Physics and Astronomy, Rice University, MS-108, P.O. Box 1892, Houston, TX 77251 (United States); Granot, Jonathan [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Kouveliotou, Chryssa [Space Science Office, VP62, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Van der Horst, Alexander; Watts, Anna L. [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam, Postbus 94249, 1090 GE Amsterdam (Netherlands); Gruber, David; Von Kienlin, Andreas [Max-Planck-Institut fuer extraterrestrische Physik, Postfach 1312, D-85748 Garching bei Mnchen (Germany); Younes, George [USRA, National Space Science and Technology Center, 320 Sparkman Drive, Huntsville, AL 35805 (United States); Gehrels, Neil, E-mail: linlin@sabanciuniv.edu [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2012-09-01

    We present the results of our broadband spectral analysis of 42 SGR J1550-5418 bursts simultaneously detected with the Swift/X-ray Telescope (XRT) and the Fermi/Gamma-ray Burst Monitor (GBM), during the 2009 January active episode of the source. The unique spectral and temporal capabilities of the XRT windowed timing mode have allowed us to extend the GBM spectral coverage for these events down to the X-ray domain (0.5-10 keV). Our earlier analysis of the GBM data found that the SGR J1550-5418 burst spectra were described equally well with either a Comptonized model or with two blackbody functions; the two models were statistically indistinguishable. Our new broadband (0.5-200 keV) spectral fits show that, on average, the burst spectra are better described with two blackbody functions than with the Comptonized model. Thus, our joint XRT-GBM analysis clearly shows for the first time that the SGR J1550-5418 burst spectra might naturally be expected to exhibit a more truly thermalized character, such as a two-blackbody or even a multi-blackbody signal. Using the Swift and RXTE timing ephemeris for SGR J1550-5418 we construct the distribution of the XRT burst counts with spin phase and find that it is not correlated with the persistent X-ray emission pulse phase from SGR J1550-5418. These results indicate that the burst emitting sites on the neutron star need not to be co-located with hot spots emitting the bulk of the persistent X-ray emission. Finally, we show that there is a significant pulse phase dependence of the XRT burst counts, likely demonstrating that the surface magnetic field of SGR J1550-5418 is not uniform over the emission zones, since it is anticipated that regions with stronger surface magnetic field could trigger bursts more efficiently.

  19. Broadband Spectral Investigations of SGR J1550-5418 Bursts

    Science.gov (United States)

    Lin, Lin; Goegues, Ersin; Baring, Matthew G.; Granot, Jonathan; Kouveliotou, Chryssa; Kaneko, Yuki; van der Horst, Alexander; Gruber, David; von Kienlin, Andreas; Younes, George; Watts, Anna L.; Gehrels, Neil

    2012-01-01

    We present the results of our broadband spectral analysis of 42 SGR J1550-5418 bursts simultaneously detected with the Swift/X-ray Telescope (XRT) and the Fermi/Gamma-ray Burst Monitor (GBM), during the 2009 January active episode of the source. The unique spectral and temporal capabilities of the XRT windowed timing mode have allowed us to extend the GBM spectral coverage for these events down to the X-ray domain (0.5-10 keV). Our earlier analysis of the GBM data found that the SGR J1550-5418 burst spectra were described equally well with either a Comptonized model or with two blackbody functions; the two models were statistically indistinguishable. Our new broadband (0.5-200 keV) spectral fits show that, on average, the burst spectra are better described with two blackbody functions than with the Comptonized model. Thus, our joint XRT-GBM analysis clearly shows for the first time that the SGR J1550-5418 burst spectra might naturally be expected to exhibit a more truly thermalized character, such as a two-blackbody or even a multi-blackbody signal. Using the Swift and RXTE timing ephemeris for SGR J1550-5418 we construct the distribution of the XRT burst counts with spin phase and find that it is not correlated with the persistent X-ray emission pulse phase from SGR J1550-5418. These results indicate that the burst emitting sites on the neutron star need not to be co-located with hot spots emitting the bulk of the persistent X-ray emission. Finally, we show that there is a significant pulse phase dependence of the XRT burst counts, likely demonstrating that the surface magnetic field of SGR J1550-5418 is not uniform over the emission zones, since it is anticipated that regions with stronger surface magnetic field could trigger bursts more efficiently.

  20. Influenza infection suppresses NADPH oxidase-dependent phagocytic bacterial clearance and enhances susceptibility to secondary MRSA infection

    Science.gov (United States)

    Sun, Keer; Metzger, Dennis W.

    2014-01-01

    Methicillin-resistant S. aureus (MRSA) has emerged as a leading contributor to mortality during recent influenza pandemics. The mechanism for this influenza-induced susceptibility to secondary S. aureus infection is poorly understood. Here we show that innate antibacterial immunity was significantly suppressed during the recovery stage of influenza infection, despite the fact that MRSA super-infection had no significant effect on viral burdens. Compared to mice infected with bacteria alone, post-influenza MRSA infected mice exhibited impaired bacterial clearance, which was not due to defective phagocyte recruitment, but rather coincided with reduced intracellular reactive oxygen species (ROS) levels in alveolar macrophages and neutrophils. NADPH oxidase is responsible for ROS production during phagocytic bacterial killing, a process also known as oxidative burst. We found that gp91phox-containing NADPH oxidase activity in macrophages and neutrophils was essential for optimal bacterial clearance during respiratory MRSA infections. In contrast to WT animals, gp91phox−/− mice exhibited similar defects in MRSA clearance before and after influenza infection. Using gp91phox+/− mosaic mice, we further demonstrate that influenza infection inhibits a cell-intrinsic contribution of NADPH oxidase to phagocyte bactericidal activity. Together, our results establish that influenza infection suppresses NADPH oxidase-dependent bacterial clearance and leads to susceptibility to secondary MRSA infection. PMID:24563256

  1. Simultaneous NuSTAR/Chandra Observations of The Bursting Pulsar GRO J1744-28 During Its Third Reactivation

    DEFF Research Database (Denmark)

    Younes, G.; Kouveliotou, C.; Grefenstette, B. W.;

    2015-01-01

    keV with an Eddington persistent flux level. Seven bursts, followed by dips, are seen with Chandra, three of which are also detected with NuSTAR. Timing analysis reveals a slight increase in the persistent emission pulsed fraction with energy (from 10% to 15%) up to 10 keV, above which it remains......We report on a 10 ks simultaneous Chandra/High Energy Transmission Grating (HETG)-Nuclear Spectroscopic Telescope Array (NuSTAR) observation of the Bursting Pulsar, GRO J1744-28, during its third detected outburst since discovery and after nearly 18 yr of quiescence. The source is detected up to 60...

  2. Understanding Neutron Stars using Thermonuclear X-ray Bursts

    Science.gov (United States)

    Bhattacharyya, S.

    2007-01-01

    Studies of thermonuclear X-ray bursts can be very useful to constrain the spin rate, mass and radius of a neutron star = EOS model of high density cold matter in the neutron star cores. Extensive observation and analysis of the data from the rising portions of the bursts = modeling of burst oscillations and thermonuclear flame spreading. Theoretical study of thermonuclear flame spreading on the rapidly spinning neutron stars should be done considering all the main physical effects (including magnetic field, nuclear energy generation, Coriolis effect, strong gravity, etc.).

  3. Neutron Stars and Thermonuclear X-ray Bursts

    Science.gov (United States)

    Bhattacharyya, Sudip

    2007-01-01

    Studies of thermonuclear X-ray bursts can be very useful to constrain the spin rate, mass and radius of a neutron star approaching EOS model of high density cold matter in the neutron star cores. +k Extensive observation and analysis of the data from the rising portions of the bursts - modeling of burst oscillations and thermonuclear flame spreading. +k Theoretical study of thermonuclear flame spreading on the rapidly spinning neutron stars should be done considering all the main physical effects (including magnetic field, nuclear energy generation, Coriolis effect, strong gravity, etc.).

  4. Dissecting the Phase Response of a Model Bursting Neuron

    CERN Document Server

    Sherwood, William Erik

    2009-01-01

    We investigate the phase response properties of the Hindmarsh-Rose model of neuronal bursting using burst phase response curves (BPRCs) computed with an infinitesimal perturbation approximation and by direct simulation of synaptic input. The resulting BPRCs have a significantly more complicated structure than the usual Type I and Type II PRCs of spiking neuronal models, and they exhibit highly timing-sensitive changes in the number of spikes per burst that lead to large magnitude phase responses. We use fast-slow dissection and isochron calculations to analyze the phase response dynamics in both weak and strong perturbation regimes.

  5. Origin of wide-band IP type II bursts

    Science.gov (United States)

    Pohjolainen, S.; Allawi, H.; Valtonen, E.

    2013-10-01

    Context. Different types of interplanetary (IP) type II bursts have been observed, where the more usual ones show narrow-band and patchy emissions, sometimes with harmonics, and which at intervals may disappear completely from the dynamic spectrum. The more unusual bursts are wide-band and diffuse, show no patches or breaks or harmonic emission, and often have long durations. Type II bursts are thought to be plasma emission, caused by propagating shock waves, but a synchrotron-emitting source has also been proposed as the origin for the wide-band type IIs. Aims: Our aim is to find out where the wide-band IP type II bursts originate and what is their connection to particle acceleration. Methods: We analyzed in detail 25 solar events that produced well-separated, wide-band IP type II bursts in 2001-2011. Their associations to flares, coronal mass ejections (CMEs), and solar energetic particle events (SEPs) were investigated. Results: Of the 25 bursts, 18 were estimated to have heights corresponding to the CME leading fronts, suggesting that they were created by bow shocks ahead of the CMEs. However, seven events were found in which the burst heights were significantly lower and which showed a different type of height-time evolution. Almost all the analyzed wide-band type II bursts were associated with very high-speed CMEs, originating from different parts of the solar hemisphere. In terms of SEP associations, many of the SEP events were weak, had poor connectivity due to the eastern limb source location, or were masked by previous events. Some of the events had precursors in specific energy ranges. These properties and conditions affected the intensity-time profiles and made the injection-time-based associations with the type II bursts difficult to interpret. In several cases where the SEP injection times could be determined, the radio dynamic spectra showed other features (in addition to the wide-band type II bursts) that could be signatures of shock fronts

  6. Efficient estimation of burst-mode LDA power spectra

    DEFF Research Database (Denmark)

    Velte, Clara Marika; George, William K

    2010-01-01

    requirements for good statistical convergence due to the random sampling of the data. In the present work, the theory for estimating burst-mode LDA spectra using residence time weighting is discussed and a practical estimator is derived and applied. A brief discussion on the self-noise in spectra...... (axisymmetric turbulent jet). The burst-mode LDA spectra are compared to corresponding spectra from hot-wire data obtained in the same experiments, and to LDA spectra produced by the sample-and-hold methodology. The spectra computed from the residence-time weighted burst-mode algorithm proposed herein compare...

  7. Search for muon neutrinos from gamma-ray bursts with the ANTARES neutrino telescope using 2008 to 2011 data

    CERN Document Server

    Adrián-Martínez, S; Samarai, I Al; André, M; Anghinolfi, M; Anton, G; Anvar, S; Ardid, M; Astraatmadja, T; Aubert, J -J; Baret, B; Barrios-Marti, J; Basa, S; Bertin, V; Biagi, S; Bigongiari, C; Bogazzi, C; Bouhou, B; Bouwhuis, M C; Brunner, J; Busto, J; Capone, A; Caramete, L; Cârloganu, C; Carr, J; Cecchini, S; Charif, Z; Charvis, Ph; Chiarusi, T; Circella, M; Classen, F; Coniglione, R; Core, L; Costantini, H; Coyle, P; Creusot, A; Curtil, C; De Bonis, G; Dekeyser, I; Deschamps, A; Distefano, C; Donzaud, C; Dornic, D; Dorosti, Q; Drouhin, D; Dumas, A; Eberl, T; Emanuele, U; Enzenhöfer, A; Ernenwein, J -P; Escoffier, S; Fehn, K; Fermani, P; Flaminio, V; Folger, F; Fritsch, U; Fusco, L A; Galatà, S; Gay, P; Geißelsöder, S; Geyer, K; Giacomelli, G; Giordano, V; Gleixner, A; Gómez-González, J P; Graf, K; Guillard, G; van Haren, H; Heijboer, A J; Hello, Y; Hernández-Rey, J J; Herold, B; Hößl, J; James, C W; de Jong, M; Kadler, M; Kalekin, O; Kappes, A; Katz, U; Kooijman, P; Kouchner, A; Kreykenbohm, I; Kulikovskiy, V; Lahmann, R; Lambard, E; Lambard, G; Larosa, G; Lefèvre, D; Leonora, E; Presti, D Lo; Loehner, H; Loucatos, S; Louis, F; Mangano, S; Marcelin, M; Margiotta, A; Martínez-Mora, J A; Martini, S; Montaruli, T; Morganti, M; Müller, C; Neff, M; Nezri, E; Palioselitis, D; Pavalas, G E; Perrina, C; Piattelli, P; Popa, V; Pradier, T; Racca, C; Riccobene, G; Richter, R; Rivière, C; Robert, A; Roensch, K; Rostovtsev, A; Samtleben, D F E; Schmid, J; Schnabel, J; Schulte, S; Schüssler, F; Seitz, T; Shanidze, R; Sieger, C; Simeone, F; Spies, A; Spurio, M; Steijger, J J M; Stolarczyk, Th; Sánchez-Losa, A; Taiuti, M; Tamburini, C; Tayalati, Y; Trovato, A; Vallage, B; Vallée, C; Van Elewyck, V; Vernin, P; Visser, E; Wagner, S; Wilms, J; de Wolf, E; Yatkin, K; Yepes, H; Zornoza, J D; Zúñiga, J; Baerwald, P

    2013-01-01

    A search for muon neutrinos in coincidence with gamma-ray bursts with the ANTARES neutrino detector using data from the end of 2007 to 2011 is performed. Expected neutrino fluxes are calculated for each burst individually. The most recent numerical calculations of the spectra using the NeuCosmA code are employed, which include Monte Carlo simulations of the full underlying photohadronic interaction processes. The discovery probability for a selection of 296 gamma-ray bursts in the given period is optimised using an extended maximum-likelihood strategy. No significant excess over background is found in the data, and 90% confidence level upper limits are placed on the total expected flux according to the model.

  8. Closest Gamma Ray Burst Providing Scientists With Crucial Test for Burst Physics

    Science.gov (United States)

    2003-05-01

    The closest Gamma Ray Burst (GRB) yet known is providing astronomers with a rare opportunity to gain information vital to understanding these powerful cosmic explosions. Extremely precise radio-telescope observations already have ruled out one proposed mechanism for the bursts. "This is the closest and brightest GRB we've ever seen, and we can use it to decipher the physics of how these bursts work," said Greg Taylor of the National Radio Astronomy Observatory (NRAO) in Socorro, NM. Taylor worked with Dale Frail, also of the NRAO, along with Prof. Shri Kulkarni and graduate student Edo Berger of Caltech in studying a GRB detected on March 29, 2003. The scientists presented their findings to the American Astronomical Society's meeting in Nashville, TN. VLBA image of GRB 030329 VLBA IMAGE of GRB 030329 CREDIT: NRAO/AUI/NSF (Click on Image for Larger Version) Taylor and Frail used the National Science Foundation's (NSF) Very Long Baseline Array (VLBA) and other radio telescopes to study the burst, known as GRB 030329. In a series of observations from April 1 to May 19, they determined the size of the expanding "fireball" from the burst and measured its position in the sky with great precision. At a distance of about 2.6 billion light-years, GRB 030329 is hardly next door. However, compared to other GRBs at typical distances of 8-10 billion light-years, it presents an easier target for study. "We only expect to see one burst per decade this close," said Frail. The precise measurement of the object's position allowed the scientists to show that one theoretical model for GRBs can be ruled out. This model, proposed in 2000, says that the radio-wave energy emitted by the GRB comes from "cannonballs" of material shot from the explosion at extremely high speeds. "The 'cannonball model' predicted that we should see the radio-emitting object move across the sky by a specific amount. We have not seen that motion," Taylor said. The currently standard "fireball model" of GRBs

  9. Stopping Frequency of Type III Solar Radio Bursts in Expanding Magnetic Flux Tubes

    CERN Document Server

    Reid, Hamish A S

    2015-01-01

    Understanding the properties of type III radio bursts in the solar corona and interplanetary space is one of the best ways to remotely deduce the characteristics of solar accelerated electron beams and the solar wind plasma. One feature of all type III bursts is the lowest frequency they reach (or stopping frequency). This feature reflects the distance from the Sun that an electron beam can drive the observable plasma emission mechanism. The stopping frequency has never been systematically studied before from a theoretical perspective. Using numerical kinetic simulations, we explore the different parameters that dictate how far an electron beam can travel before it stops inducing a significant level of Langmuir waves, responsible for plasma radio emission. We use the quasilinear approach to model self-consistently the resonant interaction between electrons and Langmuir waves in inhomogeneous plasma, and take into consideration the expansion of the guiding magnetic flux tube and the turbulent density of the in...

  10. Observations of Gamma-ray Bursts with the Fermi Large Area Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Longo, Francesco, E-mail: francesco.longo@ts.infn.it [Dipartimento di Fisica, Università di Trieste and INFN, sezione di Trieste, via Valerio 2, I-34127 Trieste (Italy); Vianello, Giacomo; Omodei, Nicola [Stanford University (HEPL), 452 Lomita Mall, Stanford, CA 94205 (United States); Piron, Frederic; Vasilieou, Vlasios [Laboratoire Univers et Particules de Montpellier, Universite de Montpellier II, CNRS/IN2P3, CC72, Place E. Bataillon, F-34095 Montpellier Cedex 5 (France); Razzaque, Soebur [Department of Physics, University of Johannesburg, P.O. Box 524, Auckland Park 2006 (South Africa)

    2014-04-01

    The Fermi observatory, with its Gamma-ray Bursts Monitor (GBM) and Large Area Telescope (LAT), is observing Gamma-ray Bursts (GRBs) with a very large spectral coverage and unprecedented sensitivity, from ∼10keV to >300GeV. In the first 3 years of the mission it observed emission above 100 MeV from 35 GRBs. In this paper we review the main results obtained on such a sample, highlighting also the relationships with the low-energy spectral and temporal features (as measured by the GBM). Some recent results on high energy photons from GRBs obtained with the preliminary Pass 8 new event-level reconstruction will be discussed.

  11. Height of burst explosions: a comparative study of numerical and experimental results

    Science.gov (United States)

    Omang, M.; Christensen, S. O.; Børve, S.; Trulsen, J.

    2009-06-01

    In the current work, we use the Constant Volume model and the numerical method, Regularized Smoothed Particle Hydrodynamics (RSPH) to study propagation and reflection of blast waves from detonations of the high explosives C-4 and TNT. The results from simulations of free-field TNT explosions are compared to previously published data, and good agreement is found. Measurements from height of burst tests performed by the Norwegian Defence Estates Agency are used to compare against numerical simulations. The results for shock time of arrival and the pressure levels are well represented by the numerical results. The results are also found to be in good agreement with results from a commercially available code. The effect of allowing different ratios of specific heat capacities in the explosive products are studied. We also evaluate the effect of changing the charge shape and height of burst on the triple point trajectory.

  12. Revisiting the potential for bursting bubbles to damage cells below the free surface

    Science.gov (United States)

    Walls, Peter; Bird, James

    2016-11-01

    The rapid motion associated with bubbles bursting at the surface of a liquid is known to cause damage to cells in a suspension, which is particularly problematic in bioreactors that require continuous injection of oxygen to sustain the cells. It is generally accepted that cells directly attached to the bubble's interface will experience lethal levels of damage. To prevent cells from initially attaching to the bubble's surface, surfactants are widely used. However, the potential for bursting bubbles to damage nearby, but not directly attached, cells is less clear. Previous numerical studies have predicted maximum energy dissipation rates (EDR) as high as 1010 W/m3 for bubbles with radii less than 1 mm; lethal to the commonly used mammalian CHO cell. Here we show that these studies tend to underestimate the generated EDR levels by several orders of magnitude due to limited numerical mesh resolution. Furthermore, we demonstrate how a downward traveling jet can cause damage away from the interface. We validate our numerical model with high-speed bubble bursting experiments and relate the dynamics of this downward jet to the boundary layer equations. We anticipate our results will be an integral step towards developing more efficient aeration platforms. We acknowledge support from Biogen Inc.

  13. Radio Nondetection of the SGR 1806-20 Giant Flare and Implications for Fast Radio Bursts

    Science.gov (United States)

    Tendulkar, Shriharsh P.; Kaspi, Victoria M.; Patel, Chitrang

    2016-08-01

    We analyze archival data from the Parkes radio telescope, which was observing a location 35.°6 away from SGR 1806-20 during its giant γ-ray flare of 2004 December 27. We show that no fast radio burst (FRB)-like burst counterpart was detected, and set a radio limit of 110 MJy at 1.4 GHz, including the estimated 70 dB suppression of the signal due to its location in the far sidelobe of Parkes and the predicted scattering from the interstellar medium. The upper limit for the ratio of magnetar giant flare radio to γ-ray fluence is η SGR ≲ 107 Jy ms erg-1 cm2. Based on the nondetection of a short and prompt γ-ray counterpart of 15 FRBs in γ-ray transient monitors, we set a lower limit on the fluence ratios of FRBs to be η FRB ≳ 107-9 Jy ms erg-1 cm2. The fluence ratio limit for SGR 1806-20 is inconsistent with all but one of the 15 FRBs. We discuss possible variations in the magnetar-FRB emission mechanism and observational caveats that may reconcile the theory with observations.

  14. SHORT GAMMA-RAY BURSTS FROM THE MERGER OF TWO BLACK HOLES

    Energy Technology Data Exchange (ETDEWEB)

    Perna, Rosalba [Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794 (United States); Lazzati, Davide [Department of Physics, Oregon State University, 301 Weniger Hall, Corvallis, OR 97331 (United States); Giacomazzo, Bruno [Physics Department, University of Trento, via Sommarive 14, I-38123 Trento (Italy)

    2016-04-10

    Short gamma-ray bursts (GRBs) are explosions of cosmic origins believed to be associated with the merger of two compact objects, either two neutron stars or a neutron star and a black hole (BH). The presence of at least one neutron star has long been thought to be an essential element of the model: its tidal disruption provides the needed baryonic material whose rapid accretion onto the post-merger BH powers the burst. The recent tentative detection by the Fermi satellite of a short GRB in association with the gravitational wave signal GW150914 produced by the merger of two BHs has challenged this standard paradigm. Here, we show that the evolution of two high-mass, low-metallicity stars with main-sequence rotational speeds a few tens of percent of the critical speed eventually undergoing a weak supernova explosion can produce a short GRB. The outer layers of the envelope of the last exploding star remain bound and circularize at large radii. With time, the disk cools and becomes neutral, suppressing the magnetorotational instability, and hence the viscosity. The disk remains “long-lived dead” until tidal torques and shocks during the pre-merger phase heat it up and re-ignite accretion, rapidly consuming the disk and powering the short GRB.

  15. The Early X-ray Afterglows of Optically Bright and Dark Gamma-Ray Bursts

    Institute of Scientific and Technical Information of China (English)

    Yi-Qing Lin

    2006-01-01

    A systematic study on the early X-ray afterglows of both optically bright and dark gamma-ray bursts (B-GRBs and D-GRBs) observed by Swift is presented. Our sample includes 25 GRBs of which 13 are B-GRBs and 12 are D-GRBs. Our results show that the distributions of the X-ray afterglow fluxes (Fx), the gamma-ray fluxes (Sγ), and the ratio (Rγ,X) are similar for the two kinds of GRBs, that any observed differences should be simply statistical fluctuation. These results indicate that the progenitors of the two kinds of GRBs are of the same population with comparable total energies of explosion. The suppression of optical emission in the D-GRBs should result from circumburst but not from their central engine.

  16. Continuous theta burst stimulation over the left pre-motor cortex affects sensorimotor timing accuracy and supraliminal error correction.

    Science.gov (United States)

    Bijsterbosch, Janine D; Lee, Kwang-Hyuk; Dyson-Sutton, William; Barker, Anthony T; Woodruff, Peter W R

    2011-09-02

    Adjustments to movement in response to changes in our surroundings are common in everyday behavior. Previous research has suggested that the left pre-motor cortex (PMC) is specialized for the temporal control of movement and may play a role in temporal error correction. The aim of this study was to determine the role of the left PMC in sensorimotor timing and error correction using theta burst transcranial magnetic stimulation (TBS). In Experiment 1, subjects performed a sensorimotor synchronization task (SMS) with the left and the right hand before and after either continuous or intermittent TBS (cTBS or iTBS). Timing accuracy was assessed during synchronized finger tapping with a regular auditory pacing stimulus. Responses following perceivable local timing shifts in the pacing stimulus (phase shifts) were used to measure error correction. Suppression of the left PMC using cTBS decreased timing accuracy because subjects tapped further away from the pacing tones and tapping variability increased. In addition, error correction responses returned to baseline tap-tone asynchrony levels faster following negative shifts and no overcorrection occurred following positive shifts after cTBS. However, facilitation of the left PMC using iTBS did not affect timing accuracy or error correction performance. Experiment 2 revealed that error correction performance may change with practice, independent of TBS. These findings provide evidence for a role of the left PMC in both sensorimotor timing and error correction in both hands. We propose that the left PMC may be involved in voluntarily controlled phase correction responses to perceivable timing shifts.

  17. Self-organized coherent bursts of stimulated Raman scattering and speckle interaction in multi-speckled laser beams

    Energy Technology Data Exchange (ETDEWEB)

    Yin, L.; Albright, B. J.; Rose, H. A.; Montgomery, D. S.; Kline, J. L.; Bowers, K. J.; Bergen, B. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Kirkwood, R. K.; Michel, P. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    2013-01-15

    Nonlinear physics governing the kinetic behavior of stimulated Raman scattering (SRS) in multi-speckled laser beams has been identified in the trapping regime over a wide range of k{lambda}{sub D} values (here k is the wave number of the electron plasma waves and {lambda}{sub D} is the Debye length) in homogeneous and inhomogeneous plasmas. Hot electrons from intense speckles, both forward and side-loss hot electrons produced during SRS daughter electron plasma wave bowing and filamentation, seed and enhance the growth of SRS in neighboring speckles by reducing Landau damping. Trapping-enhanced speckle interaction through transport of hot electrons, backscatter, and sidescatter SRS light waves enable the system of speckles to self-organize and exhibit coherent, sub-ps SRS bursts with more than 100% instantaneous reflectivity, resulting in an SRS transverse coherence width much larger than a speckle width and a SRS spectrum that peaks outside the incident laser cone. SRS reflectivity is found to saturate above a threshold laser intensity at a level of reflectivity that depends on k{lambda}{sub D}: higher k{lambda}{sub D} leads to lower SRS and the reflectivity scales as {approx}(k{lambda}{sub D}){sup -4}. As k{lambda}{sub D} and Landau damping increase, speckle interaction via sidescattered light and side-loss hot electrons decreases and the occurrence of self-organized events becomes infrequent, leading to the reduction of time-averaged SRS reflectivity. It is found that the inclusion of a moderately strong magnetic field in the laser direction can effectively control SRS by suppressing transverse speckle interaction via hot electron transport.

  18. High-energy emission from bright gamma-ray bursts using Fermi

    Energy Technology Data Exchange (ETDEWEB)

    Bissaldi, Elisabetta

    2010-05-25

    mainly based on the brightest bursts detected by GBM inside the LAT field-of-view. The determination of a consistent sample for upper-limit calculations can be established by selecting those bursts which have a strong signal in the GBM BGO detectors. The structure of this thesis can be summarized as follows: The first chapter introduces the basic concepts and scientific background of GRB physics. Afterwards, instrumental details about the Fermi instruments LAT and GBM, as well as LAT performance and capabilities for GRB science are presented in chapter 2. Chapter 3 focuses on the detector-level calibration of the GBM instrument, and in particular on the analysis methods and results, which crucially support the development of a consistent GBM instrument response. The main GBM scientific results collected during the first year of operation are then presented in chapter 4. Particular emphasis is given to the description of joint GBM-LAT and GBM-Swift observations and analysis results. The last chapter presents the selection methodology and detailed spectral analysis of a sample of well-defined BGO-bright bursts detected by GBM during its first year. Using these results, correlations among spectral parameters are finally discussed. (orig.)

  19. Neutrino astronomy and gamma-ray bursts

    CERN Document Server

    Waxman, E

    2007-01-01

    The construction of large volume detectors of high energy, >1 TeV, neutrinos is mainly driven by the search for extra-Galactic neutrino sources. The existence of such sources is implied by observations of ultra-high energy, >10^{19} eV, cosmic-rays, the origin of which is a mystery. In this lecture I briefly discuss the expected extra-Galactic neutrino signal and the current state of the experimental efforts. Neutrino emission from gamma-ray bursts (GRBs), which are likely sources of both high energy protons and neutrinos, is discussed in some detail. The detection of the predicted GRB neutrino signal, which may become possible in the coming few years, will allow one to identify the sources of ultra-high energy cosmic-rays and to resolve open questions related to the underlying physics of GRB models. Moreover, detection of GRB neutrinos will allow one to test for neutrino properties (e.g. flavor oscillations and coupling to gravity) with an accuracy many orders of magnitude better than is currently possible.

  20. Energy Injections in Gamma Ray Bursts

    Science.gov (United States)

    Yu, Y. B.; Wu, X. F.; Huang, Y. F.; Xu, M.

    2016-06-01

    In this study, we will introduce some special events, such as GRBs 081029, 100814A and 111209A. Unexpected features, such as multiple X-ray flares and significant optical rebrightenings, are observed in their afterglow light curves, unveiling the late-time activities of the central engines. Here, we will summarize our previous numerical results of these three bursts by using the energy injection model. Especially, we will focus on GRB 100814A, with an early-time shallow decay phase and a late-time significant rebrightening in its optical afterglow light curve. To explain the complex multi-band afterglow emission of GRB 100814A, we invoke a magnetar with spin evolution as its central engine. We argue that the optical shallow decay phase and the X-ray plateau are due to energy injection from t he magnetar in its early spin-down stage, while the significant optical rebrightening observed at late time naturally comes from the spin-up process of the magnetar, which is caused by subsequent fall back accretion.

  1. The SVOM gamma-ray burst mission

    CERN Document Server

    Cordier, B; Atteia, J -L; Basa, S; Claret, A; Daigne, F; Deng, J; Dong, Y; Godet, O; Goldwurm, A; Götz, D; Han, X; Klotz, A; Lachaud, C; Osborne, J; Qiu, Y; Schanne, S; Wu, B; Wang, J; Wu, C; Xin, L; Zhang, B; Zhang, S -N

    2015-01-01

    We briefly present the science capabilities, the instruments, the operations, and the expected performance of the SVOM mission. SVOM (Space-based multiband astronomical Variable Objects Monitor) is a Chinese-French space mission dedicated to the study of Gamma-Ray Bursts (GRBs) in the next decade. The SVOM mission encompasses a satellite carrying four instruments to detect and localize the prompt GRB emission and measure the evolution of the afterglow in the visible band and in X-rays, a VHF communication system enabling the fast transmission of SVOM alerts to the ground, and a ground segment including a wide angle camera and two follow-up telescopes. The pointing strategy of the satellite has been optimized to favor the detection of GRBs located in the night hemisphere. This strategy enables the study of the optical emission in the first minutes after the GRB with robotic observatories and the early spectroscopy of the optical afterglow with large telescopes to measure the redshifts. The study of GRBs in the...

  2. The Nature of Gamma Ray Burst Supernovae

    CERN Document Server

    Cano, Zach

    2012-01-01

    Gamma Ray Bursts (GRBs) and Supernovae (SNe) are among the brightest and most energetic physical processes in the universe. It is known that core-collapse SNe arise from the gravitational collapse and subsequent explosion of massive stars (the progen- itors of nearby core-collapse SNe have been imaged and unambiguously identified). It is also believed that the progenitors of long-duration GRBs (L-GRBs) are massive stars, mainly due to the occurrence and detection of very energetic core-collapse su- pernovae that happen both temporally and spatially coincident with most L-GRBs. However many outstanding questions regarding the nature of these events exist: How massive are the progenitors? What evolutionary stage are they at when they explode? Do they exist as single stars or in binary systems (or both, and to what fractions)? The work presented in this thesis attempts to further our understanding at the types of progenitors that give rise to long-duration GRB supernovae (GRB-SNe). This work is based on optical ...

  3. Afterglow Radiation from Gamma Ray Bursts

    Energy Technology Data Exchange (ETDEWEB)

    Desmond, Hugh; /Leuven U. /SLAC

    2006-08-28

    Gamma-ray bursts (GRB) are huge fluxes of gamma rays that appear randomly in the sky about once a day. It is now commonly accepted that GRBs are caused by a stellar object shooting off a powerful plasma jet along its rotation axis. After the initial outburst of gamma rays, a lower intensity radiation remains, called the afterglow. Using the data from a hydrodynamical numerical simulation that models the dynamics of the jet, we calculated the expected light curve of the afterglow radiation that would be observed on earth. We calculated the light curve and spectrum and compared them to the light curves and spectra predicted by two analytical models of the expansion of the jet (which are based on the Blandford and McKee solution of a relativistic isotropic expansion; see Sari's model [1] and Granot's model [2]). We found that the light curve did not decay as fast as predicted by Sari; the predictions by Granot were largely corroborated. Some results, however, did not match Granot's predictions, and more research is needed to explain these discrepancies.

  4. Photon Mass Limits from Fast Radio Bursts

    CERN Document Server

    Bonetti, Luca; Mavromatos, Nikolaos E.; Sakharov, Alexander S.; Sarkisyan-Grinbaum, Edward K.G.; Spallicci, Alessandro D.A.M.

    2016-01-01

    The frequency-dependent time delays in fast radio bursts (FRBs) can be used to constrain the photon mass, if the FRB redshifts are known, but the similarity between the frequency dependences of dispersion due to plasma effects and a photon mass complicates the derivation of a limit on $m_\\gamma$. The redshift of FRB 150418 has been measured to $\\sim 2$% and its dispersion measure (DM) is known to $\\sim 0.1$%, but the strength of the constraint on $m_\\gamma$ is limited by uncertainties in the modelling of the host galaxy and the Milky Way, as well as possible inhomogeneities in the intergalactic medium (IGM). Allowing for these uncertainties, the recent data on FRB 150418 indicate that $m_\\gamma \\lesssim 1.7 \\times 10^{-14}$ eV c$^{-2}$ ($4.6 \\times 10^{-50}$ kg). In the future, the different redshift dependences of the plasma and photon mass contributions to DM can be used to improve the sensitivity to $m_\\gamma$ if more FRB redshifts are measured. For a fixed fractional uncertainty in the extra-galactic cont...

  5. Detecting fast radio bursts at decametric wavelengths

    CERN Document Server

    Rajwade, Kaustubh

    2016-01-01

    Fast radio bursts (FRBs) are highly dispersed, sporadic radio pulses that are likely extragalactic in nature. Here we investigate the constraints on the source population from surveys carried out at frequencies $<1$~GHz. All but one FRB has so far been discovered in the 1--2~GHz band, but new and emerging instruments look set to become valuable probes of the FRB population at sub-GHz frequencies in the near future. In this paper, we consider the impacts of free-free absorption and multi-path scattering in our analysis via a number of different assumptions about the intervening medium. We consider previous low frequency surveys alongwith an ongoing survey with the University of Technology digital backend for the Molonglo Observatory Synthesis Telescope (UTMOST) as well as future observations with the Canadian Hydrogen Intensity Mapping Experiment (CHIME) and the Hydrogen Intensity and Real-Time Analysis Experiment (HIRAX). We predict that CHIME and HIRAX will be able to observe $\\sim$ 30 or more FRBs per da...

  6. Photon mass limits from fast radio bursts

    Science.gov (United States)

    Bonetti, Luca; Ellis, John; Mavromatos, Nikolaos E.; Sakharov, Alexander S.; Sarkisyan-Grinbaum, Edward K.; Spallicci, Alessandro D. A. M.

    2016-06-01

    The frequency-dependent time delays in fast radio bursts (FRBs) can be used to constrain the photon mass, if the FRB redshifts are known, but the similarity between the frequency dependences of dispersion due to plasma effects and a photon mass complicates the derivation of a limit on mγ. The dispersion measure (DM) of FRB 150418 is known to ∼ 0.1%, and there is a claim to have measured its redshift with an accuracy of ∼ 2%, but the strength of the constraint on mγ is limited by uncertainties in the modelling of the host galaxy and the Milky Way, as well as possible inhomogeneities in the intergalactic medium (IGM). Allowing for these uncertainties, the recent data on FRB 150418 indicate that mγ ≲ 1.8 ×10-14 eVc-2 (3.2 ×10-50 kg), if FRB 150418 indeed has a redshift z = 0.492 as initially reported. In the future, the different redshift dependences of the plasma and photon mass contributions to DM can be used to improve the sensitivity to mγ if more FRB redshifts are measured. For a fixed fractional uncertainty in the extra-galactic contribution to the DM of an FRB, one with a lower redshift would provide greater sensitivity to mγ.

  7. Blueshifting may explain the gamma ray bursts

    CERN Document Server

    Krasiński, Andrzej

    2015-01-01

    It is shown that the basic observed properties of the gamma-ray bursts (GRBs) are accounted for if one assumes that the GRBs arise by blueshifting the emission radiation of hydrogen and helium generated during the last scattering epoch. The blueshift generator for a single GRB is a Lema\\^{\\i}tre -- Tolman (L--T) region with a nonconstant bang-time function $t_B(r)$ matched into a Friedmann background. Blueshift visible to the observer arises \\textit{only on radial rays} that are emitted in the L--T region. The paper presents three L--T models with different Big Bang profiles, adapted for the highest and the lowest end of the GRB frequency range. The models account for: (1) The observed frequency range of the GRBs; (2) Their limited duration; (3) The afterglows; (4) Their hypothetical collimation into narrow jets; (5) The large distances to their sources; (6) The multitude of the observed GRBs. Properties (2), (3) and (6) are accounted for only qualitatively. With a small correction of the parameters of the mo...

  8. Studying the WHIM with Gamma Ray Bursts

    CERN Document Server

    Branchini, E; Corsi, A; Martizzi, D; Amati, L; Herder, J W den; Galeazzi, M; Gendre, B; Kaastra, J; Moscardini, L; Nicastro, F; Ohashi, T; Paerels, F; Piro, L; Roncarelli, M; Takei, Y; Viel, M

    2009-01-01

    We assess the possibility to detect and characterize the physical state of the missing baryons at low redshift by analyzing the X-ray absorption spectra of the Gamma Ray Burst [GRB] afterglows, measured by a micro calorimeters-based detector with 3 eV resolution and 1000 cm2 effective area and capable of fast re-pointing, similar to that on board of the recently proposed X-ray satellites EDGE and XENIA. For this purpose we have analyzed mock absorption spectra extracted from different hydrodynamical simulations used to model the properties of the Warm Hot Intergalactic Medium [WHIM]. These models predict the correct abundance of OVI absorption lines observed in UV and satisfy current X-ray constraints. According to these models space missions like EDGE and XENIA should be able to detect about 60 WHIM absorbers per year through the OVII line. About 45 % of these have at least two more detectable lines in addition to OVII that can be used to determine the density and the temperature of the gas. Systematic error...

  9. WATCH observations of gamma ray bursts during 1990–1992

    DEFF Research Database (Denmark)

    Castro-Tirado, A.; Brandt, Søren; Lund, Niels;

    1994-01-01

    The first WATCH/GRANAT Gamma‐Ray Burst Catalogue comprises 70 events which have been detected by WATCH during the period December 1989–September 1992. 32 GRBs could be localized within a 3σ error radii of 1°. We have found a weak (2.2σ) clustering of these 32 bursts towards the Galactic Center....... However we conclude that there is no strong evidence of concentration of the bursts towards the Galactic Center or Plane. Around ∼10% of the 70 bursts showed x‐ray precursor or/and X‐ray tail. We discuss the possibility that two events, GRB 900126 and GRB 920311, would have been produced by the same...

  10. Model Atmospheres for X-ray Bursting Neutron Stars

    CERN Document Server

    Medin, Zach; Calder, Alan C; Fontes, Christopher J; Fryer, Chris L; Hungerford, Aimee L

    2016-01-01

    The hydrogen and helium accreted by X-ray bursting neutron stars is periodically consumed in runaway thermonuclear reactions that cause the entire surface to glow brightly in X-rays for a few seconds. With models of the emission, the mass and radius of the neutron star can be inferred from the observations. By simultaneously probing neutron star masses and radii, X-ray bursts are one of the strongest diagnostics of the nature of matter at extremely high densities. Accurate determinations of these parameters are difficult, however, due to the highly non-ideal nature of the atmospheres where X-ray bursts occur. Observations from X-ray telescopes such as RXTE and NuStar can potentially place strong constraints on nuclear matter once uncertainties in atmosphere models have been reduced. Here we discuss current progress on modeling atmospheres of X-ray bursting neutron stars and some of the challenges still to be overcome.

  11. Stationarity of extreme bursts in the solar wind.

    Science.gov (United States)

    Moloney, N R; Davidsen, J

    2014-05-01

    Recent results have suggested that the statistics of bursts in the solar wind vary with solar cycle. Here, we show that this variation is basically absent if one considers extreme bursts. These are defined as threshold-exceeding events over the range of high thresholds for which their number decays as a power law. In particular, we find that the distribution of duration times and energies of extreme bursts in the solar wind ε parameter and similar observables are independent of the solar cycle and in this sense stationary, and show robust asymptotic power laws with exponents that are independent of the specific threshold. This is consistent with what has been observed for solar flares and, thus, provides evidence in favor of a link between solar flares and extreme bursts in the solar wind.

  12. Auroral Kilometric Radiation and Type III Solar Radio Bursts

    Science.gov (United States)

    Romantsova, T. V.; Mogilevsky, M. M.; Skalsky, A. A.; Hanasz, J.

    2009-04-01

    Simultaneous wave observations onboard the ISEE-1 and ISEE-3 spacecraft show that onsets of the Auroral Kilometric Radiation frequently coincide with an arrival of type III solar burst (Calvert, 1981). It was supposed that solar burst stimulates maser instability in auroral region and AKR consequently . We present statistical and case studies of events when both type III solar radio bursts and Auroral Kilometric Radiation are recorded simultaneously. AKR was observed onboard the INTERBALL-2 spacecraft orbiting around the Earth by the POLRAD experiment. Wave measurements carried out onboard the Wind, INTEBALL-TAIL and Geotail spacecraft are used to identify unambiguously the type III solar radio bursts. The origin of close relation between onsets of both solar radiation and AKR is discussed and interpreted. Acknowledgements. This work is supported by grant RFBR 06-02-72560.

  13. Fireball and cannonball models of gamma ray bursts confront observations

    OpenAIRE

    Dar, Arnon

    2005-01-01

    The two leading contenders for the theory of gamma-ray bursts (GRBs) and their afterglows, the Fireball and Cannonball models, are compared and their predictions are confronted, within space limitations, with key GRB observations, including recent observations with SWIFT

  14. Design and analysis of optical burst-switched networks

    Science.gov (United States)

    Xiong, Yijun; Vandenhoute, Marc; Cankaya, Hakki C.

    1999-08-01

    Optical burst switching (OBS) is a promising solution for building terabit optical routers and realizing IP over D- WDM. In this paper, we describe the basic concept of OBS and a general architecture of optical routers. The key design issues related to the OBS are discussed, notably, burstification, offset-time management and channel scheduling. A simple channel scheduling algorithm called LAUC (Latest Available Unscheduled Channel) algorithm is presented, which is also called Horizon algorithm in the literature. The performance of optical routers under random and self-similar traffic is thoroughly studied via computer simulations. Our study indicates that the distribution of burst length is not exponential any more. For the FDL (fiber delay line) optical buffer, the burst loss ratio is quite sensitive to the traffic characteristic of bursts when using the LAUC algorithm.

  15. Self-similar traffic analysis in optical burst assembly

    Institute of Scientific and Technical Information of China (English)

    Sui Zhicheng; Zeng Qingji; Xiao Shilin

    2005-01-01

    This paper investigates the traffic properties before and after assembly at edge node of Ethernet over optical burst switching (OBS) network for the first time. Burst and inter-arrival time distributions are simulated under time-based and length-based assembly schemes. Self-similar traffic Hurst parameter is compared through R/S and V/T plot. Finally three self-similar traffic generating methods are given. Simulation results demonstrate that, multi-source traffic increases self-similar degree, however after assembly, time-based scheme can decrease self-similar degree, and aggregated burst size is close to Gaussian distribution. Length-based method has no effects on the self-similarity of input traffic. RMD is fit for study of burst network with large self-similarity.

  16. The LOFT Burst Alert System and its Burst On-board Trigger

    DEFF Research Database (Denmark)

    Schanne, Stephane; Götz, Diego; Provost, Herve Le

    2014-01-01

    by the primary instrument LAD (Large Area Detector), sensitive to X-rays from 2 to 50 keV, offering a very large effective area (>10 m 2 ), but a small field of view ({\\o}{\\pi} sr), the WFM actually detects all types of transient sources, including Gamma-Ray Bursts (GRBs), which are of primary interest......The ESA M3 candidate mission LOFT (Large Observatory For x-ray Timing) has been designed to study strong gravitational fields by observing compact objects, such as black-hole binaries or neutron-star systems and supermassive black-holes, based on the temporal analysis of photons collected...

  17. NUMERICAL SIMULATION OF BED DEFORMATION IN DIKE BURST

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The key point in the numerical simulation of breach growth and bed deformation process in a dike burst is the accurate computation of flow and sediment transport. A numerical model for horizontal 2-D non-uniform sediment was developed to simulate the bed deformation process in the dike burst. The first-order scheme was used in computation. Several simulated results were worked out to demonstrate the applicability of the numerical model.

  18. DETECTING THE SUPERNOVA BREAKOUT BURST IN TERRESTRIAL NEUTRINO DETECTORS

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, Joshua; Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Dolence, Joshua C., E-mail: joshuajw@astro.princeton.edu [Computational Physics Group (CCS-2), MS-K784, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States)

    2016-02-01

    We calculate the distance-dependent performance of a few representative terrestrial neutrino detectors in detecting and measuring the properties of the ν{sub e} breakout burst light curve in a Galactic core-collapse supernova. The breakout burst is a signature phenomenon of core collapse and offers a probe into the stellar core through collapse and bounce. We examine cases of no neutrino oscillations and oscillations due to normal and inverted neutrino-mass hierarchies. For the normal hierarchy, other neutrino flavors emitted by the supernova overwhelm the ν{sub e} signal, making a detection of the breakout burst difficult. For the inverted hierarchy (IH), some detectors at some distances should be able to see the ν{sub e} breakout burst peak and measure its properties. For the IH, the maximum luminosity of the breakout burst can be measured at 10 kpc to accuracies of ∼30% for Hyper-Kamiokande (Hyper-K) and ∼60% for the Deep Underground Neutrino Experiment (DUNE). Super-Kamiokande (Super-K) and Jiangmen Underground Neutrino Observatory (JUNO) lack the mass needed to make an accurate measurement. For the IH, the time of the maximum luminosity of the breakout burst can be measured in Hyper-K to an accuracy of ∼3 ms at 7 kpc, in DUNE to ∼2 ms at 4 kpc, and JUNO and Super-K can measure the time of maximum luminosity to an accuracy of ∼2 ms at 1 kpc. Detector backgrounds in IceCube render a measurement of the ν{sub e} breakout burst unlikely. For the IH, a measurement of the maximum luminosity of the breakout burst could be used to differentiate between nuclear equations of state.

  19. Narrow band characteristics of Jovian L-bursts.

    Science.gov (United States)

    Barrow, C. H.

    1971-01-01

    Review of some radio observations of Jupiter made during three recent apparitions using several receivers, each tuned to a slightly different frequency close to 18 MHz. Sequences of oppositely polarized bursts have been observed and also differences in polarization mode between channels 400 kHz apart. Occasionally, isolated bursts of durations of 1 to 2 sec have been found to show real drifts in frequency, as distinct from the apparent drifts shown by changing intensity across a group of features.

  20. Emission Patterns of Solar Type III Radio Bursts: Stereoscopic Observations

    Science.gov (United States)

    Thejappa, G.; MacDowall, R.; Bergamo, M.

    2012-01-01

    Simultaneous observations of solar type III radio bursts obtained by the STEREO A, B, and WIND spacecraft at low frequencies from different vantage points in the ecliptic plane are used to determine their directivity. The heliolongitudes of the sources of these bursts, estimated at different frequencies by assuming that they are located on the Parker spiral magnetic field lines emerging from the associated active regions into the spherically symmetric solar atmosphere, and the heliolongitudes of the spacecraft are used to estimate the viewing angle, which is the angle between the direction of the magnetic field at the source and the line connecting the source to the spacecraft. The normalized peak intensities at each spacecraft Rj = Ij /[Sigma]Ij (the subscript j corresponds to the spacecraft STEREO A, B, and WIND), which are defined as the directivity factors are determined using the time profiles of the type III bursts. It is shown that the distribution of the viewing angles divides the type III bursts into: (1) bursts emitting into a very narrow cone centered around the tangent to the magnetic field with angular width of approximately 2 deg and (2) bursts emitting into a wider cone with angular width spanning from [approx] -100 deg to approximately 100 deg. The plots of the directivity factors versus the viewing angles of the sources from all three spacecraft indicate that the type III emissions are very intense along the tangent to the spiral magnetic field lines at the source, and steadily fall as the viewing angles increase to higher values. The comparison of these emission patterns with the computed distributions of the ray trajectories indicate that the intense bursts visible in a narrow range of angles around the magnetic field directions probably are emitted in the fundamental mode, whereas the relatively weaker bursts visible to a wide range of angles are probably emitted in the harmonic mode.

  1. When should we expect early bursts of trait evolution in comparative data? Predictions from an evolutionary food web model.

    Science.gov (United States)

    Ingram, T; Harmon, L J; Shurin, J B

    2012-09-01

    Conceptual models of adaptive radiation predict that competitive interactions among species will result in an early burst of speciation and trait evolution followed by a slowdown in diversification rates. Empirical studies often show early accumulation of lineages in phylogenetic trees, but usually fail to detect early bursts of phenotypic evolution. We use an evolutionary simulation model to assemble food webs through adaptive radiation, and examine patterns in the resulting phylogenetic trees and species' traits (body size and trophic position). We find that when foraging trade-offs result in food webs where all species occupy integer trophic levels, lineage diversity and trait disparity are concentrated early in the tree, consistent with the early burst model. In contrast, in food webs in which many omnivorous species feed at multiple trophic levels, high levels of turnover of species' identities and traits tend to eliminate the early burst signal. These results suggest testable predictions about how the niche structure of ecological communities may be reflected by macroevolutionary patterns.

  2. X-ray Spectroscopy of Bursts from SGR 1806-20 with RXTE

    CERN Document Server

    Strohmayer, T E; Strohmayer, Tod E.; Ibrahim, Alaa

    1998-01-01

    We report on new RXTE X-ray spectral analysis of bursts from SGR 1806-20, the most prolific SGR source known. Previous studies of bursts from this source revealed a remarkable lack of spectral variability both in single bursts as well as from burst to burst. We present here some of the first evidence for significant spectral evolution within SGR bursts. We find that optically thin thermal bremsstrahlung (OTTB) spectra including photoelectric absorption provide the best fits to most bursts, however, other models (power law, Band GRB) can also produce statistically acceptable fits. We confirm the existence of a rolloff in the photon number spectrum below 5 keV.

  3. Rock burst prevention based on dissipative structure theory

    Institute of Scientific and Technical Information of China (English)

    Song Dazhao; Wang Enyuan; Li Nan; Jin Mingyue; Xue Shipeng

    2012-01-01

    Dynamic collapses of deeply mined coal rocks are severe.In order to explore new ideas for rock burst prevention,the relationship between entropy equations and dissipative structure was studied,and a concept-rock burst activity system (RAS) was proposed and its entropy was analyzed.The energy features of RAS were analyzed,and the relationship between electromagnetic radiation (EMR) intensity E and dissipated energy Ud was initially established.We suggest that rock burst normally happens only when d,S<< -des in RAS:RAS is the dissipative structure before collapse,and after which it become a new orderly structure,i.e.,a "dead",a statically orderly structure.We advanced that the effective way to prevent rock burst is to introduce entropy to the system for it keeps the system away from the dissipative structure.E and Ud of RAS are positively related,which is used as a bridge between dissipative structure theory and rock burst prevention engineering applications.Based on this.and using the data of rock burst prevention for working face No.250205up of Yanbei coal mine,an engineering verification for the dissipative structure of RAS was carried out,which showed good results.

  4. MAXI observations of long X-ray bursts

    Science.gov (United States)

    Serino, Motoko; Iwakiri, Wataru; Tamagawa, Toru; Sakamoto, Takanori; Nakahira, Satoshi; Matsuoka, Masaru; Yamaoka, Kazutaka; Negoro, Hitoshi

    2016-12-01

    We report nine long X-ray bursts from neutron stars, detected with the Monitor of All-sky X-ray Image (MAXI). Some of these bursts lasted for hours, and hence are qualified as superbursts, which are prolonged thermonuclear flashes on neutron stars and are relatively rare events. MAXI observes roughly 85% of the whole sky every 92 minutes in the 2-20 keV energy band, and has detected nine bursts with a long e-folding decay time, ranging from 0.27 to 5.2 hr, since its launch in 2009 August until 2015 August. The majority of the nine events were found to originate from transient X-ray sources. The persistent luminosities of the sources, when these prolonged bursts were observed, were lower than 1% of the Eddington luminosity for five of them and lower than 20% for the rest. This trend is contrastive to the 18 superbursts observed before MAXI, all but two of which originated from bright persistent sources. The distribution of the total emitted energy, i.e., the product of e-folding time and luminosity, of these bursts clusters around 1041-1042 erg, whereas both the e-folding time and luminosity ranges for an order of magnitude. Among the nine events, two were from 4U 1850-086 during phases of relatively low persistent flux, whereas it usually exhibits standard short X-ray bursts during outbursts.

  5. Understanding the Continuum Spectra of Short Soft Gamma Repeater Bursts

    Science.gov (United States)

    Gogus, Ersin; Woods, Peter M.; Kouveliotou, Chryssa; Finger, Mark H.; Lenter, Geoffrey; Patel, Sandeep K.; Swank, Jean

    2006-01-01

    The spectra of short soft gamma repeater (SGR) bursts at photon energies above -15 keV are often well described by an optically thin thermal bremsstrahlung model (i.e., F(E) - E^-1 * exp(-E/kT) ) with kT=20-40 keV. However, the spectral shape burst continuum at lower photon energies (down to -2 keV) is not well established. It is important to better understand the SGR burst spectral properties at lower energies since inadequate description of the burst spectral continuum could lead to incorrect conclusions, such as existence of spectral lines. Here, we present detailed spectral investigations (in 2-200 keV) of 163 bursts from SGR 1806-20, all detected with Rossi X-ray Timing Explorer during the 2004 active episode that included the giant flare on 27 December 2004. We find that the great majority of burst spectra are well represented by the combination of a blackbody plus a OTTB models.

  6. Gamma-Ray Bursts Above 1 GeV

    CERN Document Server

    Baring, M G

    1997-01-01

    One of the principal results obtained by the Compton Gamma Ray Observatory relating to the study of gamma-ray bursts was the detection by the EGRET instrument of energetic ($>$100 MeV) photons from a handful of bright bursts. The most extreme of these was the single 18 GeV photon from the GRB940217 source. Given EGRET's sensitivity and limited field of view, the detection rate implies that such high energy emission may be ubiquitous in bursts. Hence expectations that bursts emit out to at least TeV energies are quite realistic, and the associated target-of-opportunity activity of the TeV gamma-ray community is well-founded. This review summarizes the observations and a handful of theoretical models for generating GeV--TeV emission in bursts sources, outlining possible ways that future positive detections could discriminate between different scenarios. The power of observations in the GeV--TeV range to distinguish between spectral structure intrinsic to bursts and that due to the intervening medium between sou...

  7. Detection of bursts and pauses in spike trains.

    Science.gov (United States)

    Ko, D; Wilson, C J; Lobb, C J; Paladini, C A

    2012-10-15

    Midbrain dopaminergic neurons in vivo exhibit a wide range of firing patterns. They normally fire constantly at a low rate, and speed up, firing a phasic burst when reward exceeds prediction, or pause when an expected reward does not occur. Therefore, the detection of bursts and pauses from spike train data is a critical problem when studying the role of phasic dopamine (DA) in reward related learning, and other DA dependent behaviors. However, few statistical methods have been developed that can identify bursts and pauses simultaneously. We propose a new statistical method, the Robust Gaussian Surprise (RGS) method, which performs an exhaustive search of bursts and pauses in spike trains simultaneously. We found that the RGS method is adaptable to various patterns of spike trains recorded in vivo, and is not influenced by baseline firing rate, making it applicable to all in vivo spike trains where baseline firing rates vary over time. We compare the performance of the RGS method to other methods of detecting bursts, such as the Poisson Surprise (PS), Rank Surprise (RS), and Template methods. Analysis of data using the RGS method reveals potential mechanisms underlying how bursts and pauses are controlled in DA neurons.

  8. The host galaxy of a fast radio burst.

    Science.gov (United States)

    Keane, E F; Johnston, S; Bhandari, S; Barr, E; Bhat, N D R; Burgay, M; Caleb, M; Flynn, C; Jameson, A; Kramer, M; Petroff, E; Possenti, A; van Straten, W; Bailes, M; Burke-Spolaor, S; Eatough, R P; Stappers, B W; Totani, T; Honma, M; Furusawa, H; Hattori, T; Morokuma, T; Niino, Y; Sugai, H; Terai, T; Tominaga, N; Yamasaki, S; Yasuda, N; Allen, R; Cooke, J; Jencson, J; Kasliwal, M M; Kaplan, D L; Tingay, S J; Williams, A; Wayth, R; Chandra, P; Perrodin, D; Berezina, M; Mickaliger, M; Bassa, C

    2016-02-25

    In recent years, millisecond-duration radio signals originating in distant galaxies appear to have been discovered in the so-called fast radio bursts. These signals are dispersed according to a precise physical law and this dispersion is a key observable quantity, which, in tandem with a redshift measurement, can be used for fundamental physical investigations. Every fast radio burst has a dispersion measurement, but none before now have had a redshift measurement, because of the difficulty in pinpointing their celestial coordinates. Here we report the discovery of a fast radio burst and the identification of a fading radio transient lasting ~6 days after the event, which we use to identify the host galaxy; we measure the galaxy's redshift to be z = 0.492 ± 0.008. The dispersion measure and redshift, in combination, provide a direct measurement of the cosmic density of ionized baryons in the intergalactic medium of ΩIGM = 4.9 ± 1.3 per cent, in agreement with the expectation from the Wilkinson Microwave Anisotropy Probe, and including all of the so-called 'missing baryons'. The ~6-day radio transient is largely consistent with the radio afterglow of a short γ-ray burst, and its existence and timescale do not support progenitor models such as giant pulses from pulsars, and supernovae. This contrasts with the interpretation of another recently discovered fast radio burst, suggesting that there are at least two classes of bursts.

  9. Prompt Optical Emission from Gamma-ray Bursts

    CERN Document Server

    Kehoe, R; Balsano, R; Barthelmy, S D; Bloch, J; Butterworth, P S; Casperson, D E; Cline, T; Fletcher, S; Frontera, F; Gisler, G; Heise, J; Hills, J; Hurley, K; Lee, B; Marshall, S; McKay, T; Pawl, A; Piro, L; Priedhorsky, B; Szymanski, J J; Wren, J; Kehoe, Robert; Akerlof, Carl; Balsano, Richard; Barthelmy, Scott; Bloch, Jeff; Butterworth, Paul; Casperson, Don; Cline, Tom; Fletcher, Sandra; Frontera, Fillippo; Gisler, Galen; Heise, John; Hills, Jack; Hurley, Kevin; Lee, Brian; Marshall, Stuart; Kay, Tim Mc; Pawl, Andrew; Piro, Luigi; Priedhorsky, Bill; Szymanski, John; Wren, Jim

    2001-01-01

    The Robotic Optical Transient Search Experiment (ROTSE) seeks to measure contemporaneous and early afterglow optical emission from gamma-ray bursts (GRBs). The ROTSE-I telescope array has been fully automated and responding to burst alerts from the GRB Coordinates Network since March 1998, taking prompt optical data for 30 bursts in its first year. We will briefly review observations of GRB990123 which revealed the first detection of an optical burst occurring during the gamma-ray emission, reaching 9th magnitude at its peak. In addition, we present here preliminary optical results for seven other gamma-ray bursts. No other optical counterparts were seen in this analysis, and the best limiting sensitivities are m(V) > 13.0 at 14.7 seconds after the gamma-ray rise, and m(V) > 16.4 at 62 minutes. These are the most stringent limits obtained for GRB optical counterpart brightness in the first hour after the burst. This analysis suggests that there is not a strong correlation between optical flux and gamma-ray em...

  10. Observation of a Metric Type N Solar Radio Burst

    CERN Document Server

    Kong, Xiangliang; Feng, Shiwei; Du, Guohui; Li, Chuanyang; Koval, Artem; Vasanth, V; Wang, Bing; Guo, Fan; Li, Gang

    2016-01-01

    Type III and type-III-like radio bursts are produced by energetic electron beams guided along coronal magnetic fields. As a variant of type III bursts, Type N bursts appear as the letter "N" in the radio dynamic spectrum and reveal a magnetic mirror effect in coronal loops. Here, we report a well-observed N-shaped burst consisting of three successive branches at metric wavelength with both fundamental and harmonic components and a high brightness temperature ($>$10$^9$ K). We verify the burst as a true type N burst generated by the same electron beam from three aspects of the data. First, durations of the three branches at a given frequency increase gradually, may due to the dispersion of the beam along its path. Second, the flare site, as the only possible source of non-thermal electrons, is near the western feet of large-scale closed loops. Third, the first branch and the following two branches are localized at different legs of the loops with opposite sense of polarization. We also find that the sense of p...

  11. Identification of Bursting Water Maser Features in Orion KL

    CERN Document Server

    Hirota, Tomoya; Fujisawa, Kenta; Honma, Mareki; Kawaguchi, Noriyuki; Kim, Mi Kyoung; Kobayashi, Hideyuki; Imai, Hiroshi; Omodaka, Toshihiro; Katsunori,; Shibata, M; Shimoikura, Tomomi; Yonekura, Yoshinori

    2011-01-01

    In February 2011, a burst event of the H$_{2}$O maser in Orion KL (Kleinmann-Low object) has started after 13-year silence. This is the third time to detect such phenomena in Orion KL, followed by those in 1979-1985 and 1998. We have carried out astrometric observations of the bursting H$_{2}$O maser features in Orion KL with VERA (VLBI Exploration of Radio Astrometry), a Japanese VLBI network dedicated for astrometry. The total flux of the bursting feature at the LSR velocity of 7.58 km s$^{-1}$ reaches 4.4$\\times10^{4}$ Jy in March 2011. The intensity of the bursting feature is three orders of magnitudes larger than that of the same velocity feature in the quiescent phase in 2006. Two months later, another new feature appears at the LSR velocity of 6.95 km s$^{-1}$ in May 2011, separated by 12 mas north of the 7.58 km s$^{-1}$ feature. Thus, the current burst occurs at two spatially different features. The bursting masers are elongated along the northwest-southeast direction as reported in the previous burs...

  12. Burst and Outburst Characteristics of Magnetar 4U 0142+61

    CERN Document Server

    Gogus, Ersin; Roberts, Oliver J; Chakraborty, Manoneeta; Kaneko, Yuki; Gill, Ramandeep; Granot, Jonathan; van der Horst, Alexander J; Watts, Anna L; Baring, Matthew; Kouveliotou, Chryssa; Huppenkothen, Daniela; Younes, George

    2016-01-01

    We have compiled the most comprehensive burst sample from magnetar 4U 0142+61, comprising 27 bursts from its three burst-active episodes in 2011, 2012 and the latest one in 2015 observed with Swift/BAT and Fermi/GBM. Bursts from 4U 0142+61 morphologically resemble typical short bursts from other magnetars. However, 4U 0142+61 bursts are less energetic compared to the bulk of magnetar bursts. We uncovered an extended tail emission following a burst on 2015 February 28, with a thermal nature, cooling over a time-scale of several minutes. During this tail emission, we also uncovered pulse peak phase aligned X-ray bursts , which could originate from the same underlying mechanism as that of the extended burst tail, or an associated and spatially coincident but different mechanism.

  13. Suppressed Charmed B Decay

    Energy Technology Data Exchange (ETDEWEB)

    Snoek, Hella Leonie [Vrije Univ., Amsterdam (Netherlands)

    2009-06-02

    This thesis describes the measurement of the branching fractions of the suppressed charmed B0 → D*- a0+ decays and the non-resonant B0 → D*- ηπ+ decays in approximately 230 million Υ(4S) → B$\\bar{B}$ events. The data have been collected with the BABAR detector at the PEP-II B factory at the Stanford Linear Accelerator Center in California. Theoretical predictions of the branching fraction of the B0 → D*- a{sub 0}+ decays show large QCD model dependent uncertainties. Non-factorizing terms, in the naive factorization model, that can be calculated by QCD factorizing models have a large impact on the branching fraction of these decay modes. The predictions of the branching fractions are of the order of 10-6. The measurement of the branching fraction gives more insight into the theoretical models. In general a better understanding of QCD models will be necessary to conduct weak interaction physics at the next level. The presence of CP violation in electroweak interactions allows the differentiation between matter and antimatter in the laws of physics. In the Standard Model, CP violation is incorporated in the CKM matrix that describes the weak interaction between quarks. Relations amongst the CKM matrix elements are used to present the two relevant parameters as the apex of a triangle (Unitarity Triangle) in a complex plane. The over-constraining of the CKM triangle by experimental measurements is an important test of the Standard Model. At this moment no stringent direct measurements of the CKM angle γ, one of the interior angles of the Unitarity Triangle, are available. The measurement of the angle γ can be performed using the decays of neutral B mesons. The B0 → D*- a0+ decay is sensitive to the angle γ and, in comparison to the current decays that are being employed, could significantly

  14. Disk-Related Bursts and Fades in Young Stars

    CERN Document Server

    Findeisen, Krzysztof; Ofek, Eran; Levitan, David; Sesar, Branimir; Laher, Russ; Surace, Jason

    2013-01-01

    We present first results from a new, multiyear, time domain survey of young stars in the North America Nebula complex using the Palomar Transient Factory. Our survey is providing an unprecedented view of aperiodic variability in young stars on timescales of days to years. The analyzed sample covers R_PTF = 13.5-18 and spans a range of mid-infrared color, with larger-amplitude optical variables (exceeding 0.4 mag root-mean-squared) more likely to have mid-infrared evidence for circumstellar material. This paper characterizes infrared excess stars with distinct bursts above or fades below a baseline of lower-level variability, identifying 41 examples. The light curves exhibit a remarkable diversity of amplitudes, timescales, and morphologies, with a continuum of behaviors that can not be classified into distinct groups. Among the bursters, we identify three particularly promising sources that may represent theoretically predicted short-timescale accretion instabilities. Finally, we find that fading behavior is ...

  15. A method to localize gamma-ray bursts using POLAR

    CERN Document Server

    Suarez-Garcia, E; Hajdas, W; Lamanna, G; Lechanoine-Leluc, C; Marcinkowski, R; Mtchedlishvili, A; Orsi, S; Pohl, M; Produit, N; Rapin, D; Rybka, D; Vialle, J -P; 10.1016/j.nima.2010.10.006

    2010-01-01

    The hard X-ray polarimeter POLAR aims to measure the linear polarization of the 50-500 keV photons arriving from the prompt emission of gamma-ray bursts (GRBs). The position in the sky of the detected GRBs is needed to determine their level of polarization. We present here a method by which, despite of the polarimeter incapability of taking images, GRBs can be roughly localized using POLAR alone. For this purpose scalers are attached to the output of the 25 multi-anode photomultipliers (MAPMs) that collect the light from the POLAR scintillator target. Each scaler measures how many GRB photons produce at least one energy deposition above 50 keV in the corresponding MAPM. Simulations show that the relative outputs of the 25 scalers depend on the GRB position. A database of very strong GRBs simulated at 10201 positions has been produced. When a GRB is detected, its location is calculated searching the minimum of the chi2 obtained in the comparison between the measured scaler pattern and the database. This GRB lo...

  16. Intensity distribution function and statistical properties of fast radio bursts

    Science.gov (United States)

    Li, Long-Biao; Huang, Yong-Feng; Zhang, Zhi-Bin; Li, Di; Li, Bing

    2017-01-01

    Fast Radio Bursts (FRBs) are intense radio flashes from the sky that are characterized by millisecond durations and Jansky-level flux densities. We carried out a statistical analysis on FRBs that have been discovered. Their mean dispersion measure, after subtracting the contribution from the interstellar medium of our Galaxy, is found to be , supporting their being from a cosmological origin. Their energy released in the radio band spans about two orders of magnitude, with a mean value of erg. More interestingly, although the study of FRBs is still in a very early phase, the published collection of FRBs enables us to derive a useful intensity distribution function. For the 16 non-repeating FRBs detected by the Parkes telescope and the Green Bank Telescope, the intensity distribution can be described as , where is the observed radio fluence in units of Jy ms. Here the power-law index is significantly flatter than the expected value of 2.5 for standard candles distributed homogeneously in a flat Euclidean space. Based on this intensity distribution function, the Five-hundred-meter Aperture Spherical radio Telescope (FAST) is predicted to be able to detect about five FRBs for every 1000 h of observation time.

  17. Bilateral theta-burst TMS to influence global gestalt perception.

    Directory of Open Access Journals (Sweden)

    Bernd Ritzinger

    Full Text Available While early and higher visual areas along the ventral visual pathway in the inferotemporal cortex are critical for the recognition of individual objects, the neural representation of human perception of complex global visual scenes remains under debate. Stroke patients with a selective deficit in the perception of a complex global Gestalt with intact recognition of individual objects - a deficit termed simultanagnosia - greatly helped to study this question. Interestingly, simultanagnosia typically results from bilateral lesions of the temporo-parietal junction (TPJ. The present study aimed to verify the relevance of this area for human global Gestalt perception. We applied continuous theta-burst TMS either unilaterally (left or right or bilateral simultaneously over TPJ. Healthy subjects were presented with hierarchically organized visual stimuli that allowed parametrical degrading of the object at the global level. Identification of the global Gestalt was significantly modulated only for the bilateral TPJ stimulation condition. Our results strengthen the view that global Gestalt perception in the human brain involves TPJ and is co-dependent on both hemispheres.

  18. Bilateral theta-burst TMS to influence global gestalt perception.

    Science.gov (United States)

    Ritzinger, Bernd; Huberle, Elisabeth; Karnath, Hans-Otto

    2012-01-01

    While early and higher visual areas along the ventral visual pathway in the inferotemporal cortex are critical for the recognition of individual objects, the neural representation of human perception of complex global visual scenes remains under debate. Stroke patients with a selective deficit in the perception of a complex global Gestalt with intact recognition of individual objects - a deficit termed simultanagnosia - greatly helped to study this question. Interestingly, simultanagnosia typically results from bilateral lesions of the temporo-parietal junction (TPJ). The present study aimed to verify the relevance of this area for human global Gestalt perception. We applied continuous theta-burst TMS either unilaterally (left or right) or bilateral simultaneously over TPJ. Healthy subjects were presented with hierarchically organized visual stimuli that allowed parametrical degrading of the object at the global level. Identification of the global Gestalt was significantly modulated only for the bilateral TPJ stimulation condition. Our results strengthen the view that global Gestalt perception in the human brain involves TPJ and is co-dependent on both hemispheres.

  19. GRB090426: the farthest short gamma-ray burst?

    CERN Document Server

    Antonelli, L A; Perna, R; Amati, L; Covino, S; Cutini, S; Elia, V D; Gallozzi, S; Grazian, A; Palazzi, E; Piranomonte, S; Rossi, A; Spiro, S; Stella, L; Testa, V; Chincarini, G; Di Paola, A; Fiore, F; Fugazza, D; Giallongo, E; Maiorano, E; Masetti, N; Pedichini, F; Salvaterra, R; Tagliaferri, G; Vergani, S

    2009-01-01

    Aims. With an observed and rest-frame duration of < 2s and < 0.5s, respectively, GRB090426 could be classified as a short GRB. The prompt detection, both from space and ground-based telescopes, of a bright optical counterpart to this GRB offered a unique opportunity to complete a detailed study. Methods. Based on an extensive ground-based observational campaign, we obtained the spectrum of the optical afterglow of GRB090426, measuring its redshift and obtaining information about the medium in which the event took place. We completed follow-up observation of the afterglow optical light curve down to the brightness level of the host galaxy that we firmly identified and studied. We also retrieved and analyzed all the available high-energy data of this event, and compared the results with our findings in the optical. This represents one of the most detailed studies of a short-duration event presented so far. Results. The time properties qualify GRB090426 as a short burst. In this case, its redshift of z = 2...

  20. Apparent Luminosity Function and Statistical Properties of Fast Radio Bursts

    CERN Document Server

    Li, LongBiao; Zhang, ZhiBin; Li, Di; Li, Bing

    2016-01-01

    Fast Radio Bursts (FRBs) are intense radio flashes from the sky that are astonishingly characterized by millisecond durations and Jansky-level flux densities. Only 16 FRBs have been reported in the literature till now. We carry out a statistical analysis on these events. Their mean dispersion measure, after subtracting the contribution from the interstellar medium of our Galaxy, is found to be $\\sim 655 \\; \\rm pc\\,cm^{-3}$, strongly supporting the idea that they are of cosmological origin. Their energy release in radio band spans about three orders of magnitude, with a mean value of $\\sim 6.42\\times10^{38}$ ergs. The radio energy is found to be positively correlated with the observed fluence and the dispersion measure excess, and the fluence also shows a clear positive correlation with the FRB duration. Among all these events, FRBs 010621 and 010724 seem to form a distinct group in a few plots, indicating that there may be at lease two classes of FRBs. More interestingly, although the FRB study is still in a ...

  1. Characteristics of Period-Adding Bursting Bifurcation Without Chaos in the Chay Neuron Model

    Institute of Scientific and Technical Information of China (English)

    YANG Zhuo-Qin; LU Qi-Shao

    2004-01-01

    @@ A period-adding bursting sequence without bursting-chaos in the Chay neuron model is studied by bifurcation analysis. The genesis of each periodic bursting is separately evoked by the corresponding periodic spiking patterns through two period-doubling bifurcations, except for the period-1 bursting occurring via Hopf bifurcation. Hence,it is concluded that this period-adding bursting bifurcation without chaos has a compound bifurcation structure closely related to period-doubling bifurcations of periodic spiking in essence.

  2. More Gamma-ray Bursts from the Fermi Gamma-ray Burst Monitor

    Science.gov (United States)

    Briggs, Michael; Fermi GBM Team Team

    2017-01-01

    The Fermi Gamma-ray Burst Monitor (GBM) Team has developed an offline search for weak gamma-ray bursts which were not already detected in-orbit as ``triggers''. This search is ``untargeted'', searching all of the GBM data without guidance from other observations. The initial version of the search has been operational from January 2016, finding several likely short GRBs per month that are posted to a webpage. The GBM individual photon data are binned to various timescales, a background model is created and the binned data are searched for significant signals above the background that are coincident in two or more detectors. The current search has a latency of several days because several steps require manual intervention. An improved version will be fully automatic so that the latency in detecting candidates will be dominated by the few hours delay in receiving the data. The new version of the search will also include additional detection algorithms to increase the GRB detection rate and will also detect some long GRBs. We will report the candidates via the Gamma-ray Coordinates Network (GCN). These prompt GRB detections and localization should aid multi-messenger observations, in some cases refining localizations on timescales useful for followup observations.

  3. Gamma-Ray Burst at the extreme: "the naked-eye burst" GRB 080319B

    CERN Document Server

    Wozniak, P R; Panaitescu, A D; Wren, J A; Davis, H R; White, R R

    2008-01-01

    On 19 March 2008, the northern sky was the stage of a spectacular optical transient that for a few seconds remained visible to the naked eye. The transient was associated with GRB 080319B, a gamma-ray burst at a luminosity distance of about 6 Gpc (standard cosmology), making it the most luminous optical object ever recorded by human kind. We present comprehensive sky monitoring and multi-color optical follow-up observations of GRB 080319B collected by the RAPTOR telescope network covering the development of the explosion and the afterglow before, during, and after the burst. The extremely bright prompt optical emission revealed features that are normally not detectable. The optical and gamma-ray variability during the explosion are correlated, but the optical flux is much greater than can be reconciled with single emission mechanism and a flat gamma-ray spectrum. This extreme optical behavior is best understood as synchrotron self-Compton model (SSC). After a gradual onset of the gamma-ray emission, there is ...

  4. The Third Swift Burst Alert Telescope Gamma-Ray Burst Catalog

    CERN Document Server

    Lien, Amy; Barthelmy, Scott D; Baumgartner, Wayne H; Cannizzo, John K; Chen, Kevin; Collins, Nicholas R; Cummings, Jay R; Gehrels, Neil; Krimm, Hans A; Markwardt, Craig B; Palmer, David M; Stamatikos, Michael; Troja, Eleonora; Ukwatta, T N

    2016-01-01

    To date, the Burst Alert Telescope (BAT) onboard Swift has detected ~ 1000 gamma-ray bursts (GRBs), of which ~ 360 GRBs have redshift measurements, ranging from z = 0.03 to z = 9.38. We present the analyses of the BAT-detected GRBs for the past ~ 11 years up through GRB151027B. We report summaries of both the temporal and spectral analyses of the GRB characteristics using event data (i.e., data for each photon within approximately 250 s before and 950 s after the BAT trigger time), and discuss the instrumental sensitivity and selection effects of GRB detections. We also explore the GRB properties with redshift when possible. The result summaries and data products are available at http://swift.gsfc.nasa.gov/results/batgrbcat/index.html. In addition, we perform searches for GRB emissions before or after the event data using the BAT survey data. We estimate the false detection rate to be only one false detection in this sample. There are 15 ultra-long GRBs (~ 2% of the BAT GRBs) in this search with confirmed emi...

  5. Gamma-Ray Bursts: Pulses and Populations

    Science.gov (United States)

    Loredo, Thomas J.; Hakkila, J. E.; Broadbent, M.; Wasserman, I. M.; Wolpert, R. L.

    2013-04-01

    We describe ongoing work on two projects that are enabling more thorough and accurate use of archival BATSE data for elucidating the nature of GRB sources; the methods and tools we are developing will also be valuable for analyzing data from other missions. The first project addresses modeling the spectro-temporal behavior of prompt gamma ray emission from GRBs by modeling gamma ray count and event data with a population of pulses, with the population drawn from one or more families of single-pulse kernels. Our approach is built on a multilevel nonparametric probabilistic framework we have dubbed "Bayesian droplets," and offers several important advances over previous pulse decomposition approaches: (1) It works in the pulse-confusion regime, quantifying uncertainty in the number, locations, and shapes of pulses, even when there is strong overlap. (2) It can self-consistently model pulse behavior across multiple spectral bands. (3) It readily handles a variety of spatio-temporal kernel shapes. (4) It reifies the idea of a burst as a population of pulses, enabling explicit modeling and estimation of the pulse population distribution. We describe the framework and present analyses of prototypical simple and complex GRB light curves. The second project aims to enable accurate demographic modeling of GRBs using the BATSE catalog. We present new calculations of the BATSE sky exposure, encompassing the full duration of the BATSE catalog for the first time, with many improvements over the currently available exposure map. A similar calculation of the detection efficiency is in progress. We also describe public Python software enabling access and accurate modeling of BATSE GRB data. The software enables demographic studies (e.g., modeling log N - log S distributions) with accurate accounting of both selection effects and measurement errors. It also enables spectro-temporal modeling of detailed data from individual GRBs. These projects are supported by NASA through the AISR

  6. Detecting fast radio bursts at decametric wavelengths

    Science.gov (United States)

    Rajwade, K. M.; Lorimer, D. R.

    2017-02-01

    Fast radio bursts (FRBs) are highly dispersed, sporadic radio pulses which are likely extragalactic in nature. Here, we investigate the constraints on the source population from surveys carried out at frequencies <1 GHz. All but one FRB has so far been discovered in the 1-2 GHz band, but new and emerging instruments look set to become valuable probes of the FRB population at sub-GHz frequencies in the near future. In this paper, we consider the impacts of free-free absorption and multipath scattering in our analysis via a number of different assumptions about the intervening medium. We consider previous low-frequency surveys along with an ongoing survey with University of Technology digital backend for the Molonglo Observatory Synthesis Telescope (UTMOST) as well as future observations with the Canadian Hydrogen Intensity Mapping Experiment (CHIME) and the Hydrogen Intensity and Real-time Analysis eXperiment (HIRAX). We predict that CHIME and HIRAX will be able to observe ˜30 or more FRBs per day, even in the most extreme scenarios where free-free absorption and scattering can significantly impact the fluxes below 1 GHz. We also show that UTMOST will detect 1-2 FRBs per month of observations. For CHIME and HIRAX, the detection rates also depend greatly on the assumed FRB distance scale. Some of the models we investigated predict an increase in the FRB flux as a function of redshift at low frequencies. If FRBs are truly cosmological sources, this effect may impact future surveys in this band, particularly if the FRB population traces the cosmic star formation rate.

  7. MIRAX sensitivity for Gamma Ray Bursts

    Science.gov (United States)

    Sacahui, J. R.; Penacchioni, A. V.; Braga, J.; Castro, M. A.; D'Amico, F.

    2016-03-01

    In this work we present the detection capability of the MIRAX (Monitor e Imageador de RAios-X) experiment for Gamma-Ray Bursts (GRBs). MIRAX is an X-ray astronomy mission designed to perform a wide band hard X-ray (10-200 keV) survey of the sky, especially in the Galactic plane. With a total detection area of 169 cm2, large field of view (FoV, 20 ° × 20 °), angular resolution of 1°45‧ and good spectral and time resolution (∼8% at 60 keV, 10 μs), MIRAX will be optimized for the detection and study of transient sources, such as accreting neutron stars (NS), black holes (BH), Active Galactic Nuclei (AGNs), and both short and long GRBs. This is especially important because MIRAX is expected to operate in an epoch when probably no other hard X-ray wide-field imager will be active. We have performed detailed simulations of MIRAX GRB observations using the GEANT4 package, including the background spectrum and images of GRB sources in order to provide accurate predictions of the sensitivity for the expected GRB rate to be observed. MIRAX will be capable of detecting ∼44 GRBs per year up to redshifts of ∼4.5. The MIRAX mission will be able to contribute significantly to GRB science by detecting a large number of GRBs per year with wide band spectral response. The observations will contribute mainly to the part of GRB spectra where a thermal emission is predicted by the Fireball model. We also discuss the possibility of detecting GRB afterglows in the X-ray band with MIRAX.

  8. Upper limits from the LIGO and TAMA detectors on the rate of gravitational-wave bursts

    CERN Document Server

    Abbott, B; Adhikari, R; Ageev, A; Agresti, J; Akutsu, T; Allen, B; Allen, J; Amin, R; Anderson, S B; Anderson, W G; Ando, M; Arai, K; Araya, A; Araya, M; Armandula, H; Asada, H; Ashley, M; Asiri, F; Aso, Y; Aufmuth, P; Aulbert, C; Babak, S; Balasubramanian, R; Ballmer, S; Barish, B C; Barker, C; Barker, D; Barnes, M; Barr, B; Barton, M A; Bayer, K; Beausoleil, R; Belczynski, K; Bennett, R; Berukoff, S J; Betzwieser, J; Beyersdorf, P; Bhawal, B; Bilenko, I A; Billingsley, G; Black, E; Blackburn, K; Blackburn, L; Bland, B; Bochner, B; Bogue, L; Bork, R; Bose, S; Brady, P R; Braginsky, V B; Brau, J E; Brown, D A; Bullington, A; Bunkowski, A; Buonanno, A; Burgess, R; Busby, D; Butler, W E; Byer, R L; Cadonati, L; Cagnoli, G; Camp, J B; Cannizzo, J; Cannon, K; Cantley, C A; Cardenas, L; Carter, K; Casey, M M; Castiglione, J; Chandler, A; Chapsky, J; Charlton, P; Chatterji, S; Chelkowski, S; Chen, Y; Chickarmane, V; Chin, D; Christensen, N; Churches, D; Cokelaer, T; Colacino, C; Coldwell, R; Coles, M; Cook, D; Corbitt, T; Coyne, D; Creighton, J D E; Creighton, T D; Crooks, D R M; Csatorday, P; Cusack, B J; Cutler, C; D'Ambrosio, E; Dalrymple, J; Danzmann, K; Davies, G; Daw, E; De Bra, D; DeSalvo, R; Delker, T; Dergachev, V; Desai, S; Dhurandhar, S V; Di Credico, A; Ding, H; Drever, R W P; Dupuis, R J; Edlund, J A; Ehrens, P; Elliffe, E J; Etzel, T; Evans, M; Evans, T; Fairhurst, S; Fallnich, C; Farnham, D; Fejer, M M; Findley, T; Fine, M; Finn, L S; Franzen, K Y; Freise, A; Frey, R; Fritschel, P; Frolov, V V; Fujiki, Y; Fujimoto, M K; Fujita, R; Fukushima, M; Futamase, T; Fyffe, M; Ganezer, K S; Garofoli, J; Giaime, J A; Gillespie, A; Goda, K; Goggin, L; Goler, S; González, G; Grandclément, P; Grant, A; Gray, C; Gretarsson, A M; Grimmett, D; Grote, H; Grünewald, S; Gustafson, E; Gustafson, R; Günther, M; Hamilton, W O; Hammond, M; Hamuro, Y; Hanson, J; Hardham, C; Harms, J; Harry, G; Hartunian, A; Haruyama, T; Hayama, K; Heefner, J; Hefetz, Y; Heinzel, G; Heng, I S; Hennessy, M; Hepler, N; Heptonstall, A; Heurs, M; Hewitson, M; Hild, S; Hindman, N; Hoang, P; Hough, J; Hrynevych, M; Hua, W; Iguchi, H; Iida, Y; Ioka, K; Ishizuka, H; Ito, M; Itoh, Y; Ivanov, A; Jennrich, O; Johnson, B; Johnson, W W; Johnston, W R; Jones, D I; Jones, G; Jones, L; Jungwirth, D; Kalogera, V; Kamikubota, N; Kanda, N; Kaneyama, T; Karasawa, Y; Kasahara, K; Kasai, T; Katsavounidis, E; Katsuki, M; Kawabe, K; Kawamura, M; Kawamura, S; Kawazoe, F; Kells, W; Kern, J; Khan, A; Killbourn, S; Killow, C J; Kim, C; King, C; King, P; Klimenko, S; Kojima, Y; Kokeyama, K; Kondo, K; Koranda, S; Kotter, K; Kovalik, Yu; Kozai, Y; Kozak, D; Krishnan, B; Kudo, H; Kuroda, K; Kuwabara, T; Landry, M; Langdale, J; Lantz, B; Lawrence, R; Lazzarini, A; Lei, M; Leonor, I; Libbrecht, K; Libson, A; Lindquist, P; Liu, S; Logan, J; Lormand, M; Lubinski, M; Luck, H; Luna, M; Lyons, T T; MacInnis, M; Machenschalk, B; Mageswaran, M; Mailand, K; Majid, W; Malec, M; Mandic, V; Mann, F; Marin, A; Marka, S; Maros, E; Mason, J; Mason, K; Matherny, O; Matone, L; Matsuda, N; Mavalvala, N; McCarthy, R; McClelland, D E; McHugh, M; McNabb, J W C; Melissinos, A C; Mendell, G; Mercer, R A; Meshkov, S; Messaritaki, E; Messenger, C; Mikhailov, E; Mio, N; Mitra, S; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Miura, K; Miyakawa, O; Miyama, S; Miyoki, S; Mizusawa, H; Mohanty, S; Moreno, G; Moriwaki, S; Mossavi, K; Mukherjee, S; Murray, P; Musha, M; Myers, E; Myers, J; Müller, G; Nagano, S; Nagayama, Y; Nakagawa, K; Nakamura, T; Nakano, H; Nakao, K; Nash, T; Nayak, R; Newton, G; Nishi, Y; Nocera, F; Noel, J S; Numata, K; Nutzman, P; O'Reilly, B; Ogawa, Y; Ohashi, M; Ohishi, N; Okutomi, A; Olson, T; Oohara, K; Otsuka, S; Ottaway, D J; Ottewill, A; Ouimette, D A; Overmier, H; Owen, B J; Pan, Y; Papa, M A; Parameshwaraiah, V; Parameswaran, A J; Parameswariah, C; Pedraza, M; Penn, S; Pitkin, M; Plissi, M; Prix, R; Quetschke, V; Raab, F; Radkins, H; Rahkola, R; Rakhmanov, M; Rao, S R; Rawlins, K; Ray-Majumder, S; Re, V; Redding, D; Regehr, M W; Regimbau, T; Reid, S; Reilly, K T; Reithmaier, K; Reitze, D H; Richman, S; Riesen, R; Riles, K; Rivera, B; Rizzi, A; Robertson, D I; Robertson, N A; Robinson, C; Robison, L; Roddy, S; Rodríguez, A; Rollins, J; Romano, J D; Romie, J; Rong, H; Rose, D; Rotthoff, E; Rowan, S; Ruet, L; Russell, P; Ryan, K; Rüdiger, A; Saitô, Y; Sakata, S; Salzman, I; Sandberg, V; Sanders, G H; Sannibale, V; Sarin, P; Sasaki, M; Sathyaprakash, B; Sato, K; Sato, N; Sato, S; Sato, Y; Saulson, P R; Savage, R; Sazonov, A; Schilling, R; Schlaufman, K; Schmidt, V; Schnabel, R; Schofield, R; Schutz, B F; Schwinberg, P; Scott, S M; Seader, S E; Searle, A C; Sears, B; Seel, S; Seifert, F; Sekido, A; Sellers, D; Sengupta, A S; Seto, N; Shapiro, C A; Shawhan, P; Shibata, M; Shinkai, H; Shintomi, T; Shoemaker, D H; Shu, Q Z; Sibley, A; Siemens, X; Sievers, L; Sigg, D; Sintes, A M; Smith, J R; Smith, M; Smith, M R; Sneddon, P H; Soida, K; Somiya, K; Spero, R; Spjeld, O; Stapfer, G; Steussy, D; Strain, K A; Strom, D; Stuver, A; Summerscales, T; Sumner, M C; Sung, M; Sutton, P J; Suzuki, T; Sylvestre, J; Tagoshi, H; Takahashi, H; Takahashi, R; Takamori, A; Takemoto, S; Takeno, K; Tanaka, T; Taniguchi, K; Tanji, T; Tanner, D B; Tariq, H; Tatsumi, D; Taylor, I; Taylor, R; Telada, S; Thorne, K A; Thorne, K S; Tibbits, M; Tilav, S; Tinto, M; Tokmakov, K V; Tokunari, M; Tomaru, T; Torres, C; Torrie, C; Traylor, G; Tsubono, K; Tsuda, N; Tsunesada, Y; Tyler, W; Uchiyama, T; Ueda, A; Ueda, K; Ugolini, D W; Ungarelli, C; Vallisneri, M; Van Putten, M H P M; Vass, S; Vecchio, A; Veitch, J; Vorvick, C; Vyachanin, S P; Wallace, L; Walther, H; Ward, H; Ward, R; Ware, B; Waseda, K; Watts, K; Webber, D; Weidner, A; Weiland, U; Weinstein, A; Weiss, R; Welling, H; Wen, L; Wen, S; Wette, K; Whelan, J T; Whitcomb, S E; Whiting, B F; Wiley, S; Wilkinson, C; Willems, P A; Williams, P R; Williams, R; Willke, B; Wilson, A; Winjum, B J; Winkler, W; Wise, S; Wiseman, A G; Woan, G; Woods, D; Wooley, R; Worden, J; Wu, W; Yakushin, I; Yamamoto, A; Yamamoto, H; Yamamoto, K; Yamazaki, T; Yanagi, Y; Yokoyama, J; Yoshida, S; Yoshida, T; Zaleski, K D; Zanolin, M; Zawischa, I; Zhang, L; Zhu, R; Zhu, Z H; Zotov, N P; Zucker, M; Zweizig, J

    2005-01-01

    We report on the first joint search for gravitational waves by the TAMA and LIGO collaborations. We looked for millisecond-duration unmodelled gravitational-wave bursts in 473 hr of coincident data collected during early 2003. No candidate signals were found. We set an upper limit of 0.12 events per day on the rate of detectable gravitational-wave bursts, at 90% confidence level. From simulations, we estimate that our detector network was sensitive to bursts with root-sum-square strain amplitude above approximately 1-3x10^{-19} Hz^{-1/2} in the frequency band 700-2000 Hz. We describe the details of this collaborative search, with particular emphasis on its advantages and disadvantages compared to searches by LIGO and TAMA separately using the same data. Benefits include a lower background and longer observation time, at some cost in sensitivity and bandwidth. We also demonstrate techniques for performing coincidence searches with a heterogeneous network of detectors with different noise spectra and orientatio...

  9. Study of Temporal Evolution of Emission Spectrum in a Steeply Rising Submillimeter Burst

    CERN Document Server

    Li, J P; Wang, X D

    2015-01-01

    In the paper the spectral temporal evolution of a steeply rising submillimeter (THz) burst occurred on 2003 November 2 was investigated in detail for the first time. Observations show that the flux density of the THz spectrum increased steeply with frequency above 200 GHz. Their average rising rates reached a value of 235 sfu/GHz (corresponding spectral index $\\alpha$ of 4.8) during the burst. The flux densities reached about 4,000 and 70,000 sfu at 212 and 405 GHz at maximum phase, respectively. The emissions at 405 GHz maintained continuous high level that they exceed largely the peak values of the microwave (MW) spectra during the main phase. Our studies suggest that only energetic electrons with a low-energy cutoff of $\\sim$1 MeV and number density of $\\sim$$10^{6}$--$10^{8}$ cm$^{-3}$ can produce such strong and steeply rising THz component via gyrosynchrotron (GS) radiation based on numerical simulations of burst spectra in the nonuniform magnetic field case. The electron number density $N$, derived fro...

  10. Search for gravitational-wave bursts in the first year of the fifth LIGO science run

    Science.gov (United States)

    Abbott, B. P.; Abbott, R.; Adhikari, R.; Ajith, P.; Allen, B.; Allen, G.; Amin, R. S.; Anderson, S. B.; Anderson, W. G.; Arain, M. A.; Araya, M.; Armandula, H.; Armor, P.; Aso, Y.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Baker, P.; Ballmer, S.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barsotti, L.; Barton, M. A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Behnke, B.; Benacquista, M.; Betzwieser, J.; Beyersdorf, P. T.; Bilenko, I. A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Bland, B.; Bodiya, T. P.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Bridges, D. O.; Brinkmann, M.; Brooks, A. F.; Brown, D. A.; Brummit, A.; Brunet, G.; Bullington, A.; Buonanno, A.; Burmeister, O.; Byer, R. L.; Cadonati, L.; Camp, J. B.; Cannizzo, J.; Cannon, K. C.; Cao, J.; Cardenas, L.; Caride, S.; Castaldi, G.; Caudill, S.; Cavaglià, M.; Cepeda, C.; Chalermsongsak, T.; Chalkley, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Christensen, N.; Chung, C. T. Y.; Clark, D.; Clark, J.; Clayton, J. H.; Cokelaer, T.; Colacino, C. N.; Conte, R.; Cook, D.; Corbitt, T. R. C.; Cornish, N.; Coward, D.; Coyne, D. C.; Creighton, J. D. E.; Creighton, T. D.; Cruise, A. M.; Culter, R. M.; Cumming, A.; Cunningham, L.; Danilishin, S. L.; Danzmann, K.; Daudert, B.; Davies, G.; Daw, E. J.; Debra, D.; Degallaix, J.; Dergachev, V.; Desai, S.; Desalvo, R.; Dhurandhar, S.; Díaz, M.; di Credico, A.; Dietz, A.; Donovan, F.; Dooley, K. L.; Doomes, E. E.; Drever, R. W. P.; Dueck, J.; Duke, I.; Dumas, J.-C.; Dwyer, J. G.; Echols, C.; Edgar, M.; Effler, A.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Faltas, Y.; Fan, Y.; Fazi, D.; Fehrmann, H.; Finn, L. S.; Flasch, K.; Foley, S.; Forrest, C.; Fotopoulos, N.; Franzen, A.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V. V.; Fyffe, M.; Galdi, V.; Garofoli, J. A.; Gholami, I.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Goda, K.; Goetz, E.; Goggin, L. M.; González, G.; Gorodetsky, M. L.; Goßler, S.; Gouaty, R.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Grimaldi, F.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, E. K.; Gustafson, R.; Hage, B.; Hallam, J. M.; Hammer, D.; Hammond, G. D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Haughian, K.; Hayama, K.; Heefner, J.; Heng, I. S.; Heptonstall, A.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hodge, K. A.; Holt, K.; Hosken, D. J.; Hough, J.; Hoyland, D.; Hughey, B.; Huttner, S. H.; Ingram, D. R.; Isogai, T.; Ito, M.; Ivanov, A.; Johnson, B.; Johnson, W. W.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kanner, J.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khan, R.; Khazanov, E.; King, P.; Kissel, J. S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R.; Koranda, S.; Kozak, D.; Krishnan, B.; Kumar, R.; Kwee, P.; Lam, P. K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lei, H.; Lei, M.; Leindecker, N.; Leonor, I.; Li, C.; Lin, H.; Lindquist, P. E.; Littenberg, T. B.; Lockerbie, N. A.; Lodhia, D.; Longo, M.; Lormand, M.; Lu, P.; Lubiński, M.; Lucianetti, A.; Lück, H.; Machenschalk, B.; Macinnis, M.; Mageswaran, M.; Mailand, K.; Mandel, I.; Mandic, V.; Márka, S.; Márka, Z.; Markosyan, A.; Markowitz, J.; Maros, E.; Martin, I. W.; Martin, R. M.; Marx, J. N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McHugh, M.; McIntyre, G.; McKechan, D. J. A.; McKenzie, K.; Mehmet, M.; Melatos, A.; Melissinos, A. C.; Menéndez, D. F.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miller, J.; Minelli, J.; Mino, Y.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Mohanty, S. D.; Mohapatra, S. R. P.; Moreno, G.; Morioka, T.; Mors, K.; Mossavi, K.; Mowlowry, C.; Mueller, G.; Müller-Ebhardt, H.; Muhammad, D.; Mukherjee, S.; Mukhopadhyay, H.; Mullavey, A.; Munch, J.; Murray, P. G.; Myers, E.; Myers, J.; Nash, T.; Nelson, J.; Newton, G.; Nishizawa, A.; Numata, K.; O'Dell, J.; O'Reilly, B.; O'Shaughnessy, R.; Ochsner, E.; Ogin, G. H.; Ottaway, D. J.; Ottens, R. S.; Overmier, H.; Owen, B. J.; Pan, Y.; Pankow, C.; Papa, M. A.; Parameshwaraiah, V.; Patel, P.; Pedraza, M.; Penn, S.; Perraca, A.; Pierro, V.; Pinto, I. M.; Pitkin, M.; Pletsch, H. J.; Plissi, M. V.; Postiglione, F.; Principe, M.; Prix, R.; Prokhorov, L.; Puncken, O.; Quetschke, V.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raics, Z.; Rainer, N.; Rakhmanov, M.; Raymond, V.; Reed, C. M.; Reed, T.

    2009-11-01

    We present the results obtained from an all-sky search for gravitational-wave (GW) bursts in the 64-2000 Hz frequency range in data collected by the LIGO detectors during the first year (November 2005—November 2006) of their fifth science run. The total analyzed live time was 268.6 days. Multiple hierarchical data analysis methods were invoked in this search. The overall sensitivity expressed in terms of the root-sum-square (rss) strain amplitude hrss for gravitational-wave bursts with various morphologies was in the range of 6×10-22Hz-1/2 to a few×10-21Hz-1/2. No GW signals were observed and a frequentist upper limit of 3.75 events per year on the rate of strong GW bursts was placed at the 90% confidence level. As in our previous searches, we also combined this rate limit with the detection efficiency for selected waveform morphologies to obtain event rate versus strength exclusion curves. In sensitivity, these exclusion curves are the most stringent to date.

  11. GRB 091024A and the nature of ultra-long gamma-ray bursts

    CERN Document Server

    Virgili, F J; Pal'shin, V; Guidorzi, C; Margutti, R; Melandri, A; Harrison, R; Kobayashi, S; Chornock, R; Henden, A; Updike, A C; Cenko, S B; Tanvir, N R; Steele, I A; Cucchiara, A; Gomboc, A; Levan, A; Cano, Z; Mottram, C J; Clay, N R; Bersier, D; Kopac, D; Japelj, J; Filippenko, A V; Li, W; Svinkin, D; Golenetskii, S; Hartmann, D H; Milne, P A; Williams, G; O'Brien, P T; Fox, D B; Berger, E

    2013-01-01

    We present a broadband study of gamma-ray burst (GRB) 091024A within the context of other ultra-long-duration GRBs. An unusually long burst detected by Konus-Wind, Swift, and Fermi, GRB 091024A has prompt emission episodes covering ~1300 s, accompanied by bright and highly structured optical emission captured by various rapid-response facilities, including the 2-m autonomous robotic Faulkes North and Liverpool Telescopes, KAIT, S-LOTIS, and SRO. We also observed the burst with 8- and 10-m class telescopes and determine the redshift to be z = 1.0924 \\pm 0.0004. We find no correlation between the optical and gamma-ray peaks and interpret the optical light curve as being of external origin, caused by the reverse and forward shock of a highly magnetized jet (R_B ~ 100-200). Low-level emission is detected throughout the near-background quiescent period between the first two emission episodes of the Konus-Wind data, suggesting continued central-engine activity; we discuss the implications of this ongoing emission a...

  12. GRB 091024A and the nature of ultra-long gamma-ray bursts

    Energy Technology Data Exchange (ETDEWEB)

    Virgili, F. J.; Mundell, C. G.; Harrison, R.; Kobayashi, S.; Steele, I. A.; Mottram, C. J.; Clay, N. R. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool, L3 5RF (United Kingdom); Pal' shin, V. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation); Guidorzi, C. [Department of Physics and Earth Sciences, University of Ferrara, Via Saragat, 1, I-44122 Ferrara (Italy); Margutti, R.; Chornock, R. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Melandri, A. [INAF/Brera Astronomical Observatory, via Bianchi 46, I-23807 Merate (Italy); Henden, A. [AAVSO, 49 Bay State Road, Cambridge, MA 02138 (United States); Updike, A. C. [Department of Chemistry and Physics, Roger Williams University, Bristol, RI 02809 (United States); Cenko, S. B. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Tanvir, N. R. [Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Cucchiara, A. [Department of Astronomy and Astrophysics, UCO/Lick Observatory, University of California, 1156 High Street, Santa Cruz, CA 95064 (United States); Gomboc, A. [Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 19, 1000 Ljubljana (Slovenia); Levan, A. [Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom); Cano, Z., E-mail: F.J.Virgili@ljmu.ac.uk [Centre for Astrophysics and Cosmology, Science Institute, University of Iceland, 107 Reykjavik (Iceland); and others

    2013-11-20

    We present a broadband study of gamma-ray burst (GRB) 091024A within the context of other ultra-long-duration GRBs. An unusually long burst detected by Konus-Wind (KW), Swift, and Fermi, GRB 091024A has prompt emission episodes covering ∼1300 s, accompanied by bright and highly structured optical emission captured by various rapid-response facilities, including the 2 m autonomous robotic Faulkes North and Liverpool Telescopes, KAIT, S-LOTIS, and the Sonoita Research Observatory. We also observed the burst with 8 and 10 m class telescopes and determine the redshift to be z = 1.0924 ± 0.0004. We find no correlation between the optical and γ-ray peaks and interpret the optical light curve as being of external origin, caused by the reverse and forward shock of a highly magnetized jet (R{sub B} ≈ 100-200). Low-level emission is detected throughout the near-background quiescent period between the first two emission episodes of the KW data, suggesting continued central-engine activity; we discuss the implications of this ongoing emission and its impact on the afterglow evolution and predictions. We summarize the varied sample of historical GRBs with exceptionally long durations in gamma-rays (≳1000 s) and discuss the likelihood of these events being from a separate population; we suggest ultra-long GRBs represent the tail of the duration distribution of the long GRB population.

  13. Cosmic radio-noise absorption bursts caused by solar wind shocks

    Directory of Open Access Journals (Sweden)

    A. Osepian

    2004-09-01

    Full Text Available Bursts of cosmic noise absorption observed at times of sudden commencements (SC of geomagnetic storms are examined. About 300SC events in absorption for the period 1967-1990 have been considered. It is found that the response of cosmic radio-noise absorption to the passage of an interplanetary shock depends on the level of the planetary magnetic activity preceding the SC event and on the magnitude of the magnetic field perturbation associated with the SC (as measured in the equatorial magnetosphere. It is shown that for SC events observed against a quiet background (Kp<2, the effects of the SC on absorption can be seen only if the magnitude of the geomagnetic field perturbation caused by the solar wind shock exceeds a threshold value ΔBth. It is further demonstrated that the existence of this threshold value, ΔBth, deduced from experimental data, can be related to the existence of a threshold for exciting and maintaining the whistler cyclotron instability, as predicted by quasi-linear theory. SC events observed against an active background (Kp<2 are accompanied by absorption bursts for all magnetic field perturbations, however small. A quantitative description of absorption bursts associated with SC events is provided by the whistler cyclotron instability theory.

  14. SGR J1550-5418 bursts detected with the Fermi Gamma-ray Burst Monitor during its most prolific activity

    CERN Document Server

    van der Horst, A J; Gorgone, N M; Kaneko, Y; Baring, M G; Guiriec, S; Gogus, E; Granot, J; Watts, A L; Lin, L; Bhat, P N; Bissaldi, E; Chaplin, V L; Connaughton, V; Finger, M H; Gehrels, N; Gibby, M H; Giles, M M; Goldstein, A; Gruber, D; Harding, A K; Kaper, L; von Kienlin, A; van der Klis, M; McBreen, S; Mcenery, J; Meegan, C A; Paciesas, W S; Pe'er, A; Preece, R D; Ramirez-Ruiz, E; Rau, A; Wachter, S; Wilson-Hodge, C; Woods, P M; Wijers, R A M J

    2012-01-01

    We have performed detailed temporal and time-integrated spectral analysis of 286 bursts from SGR J1550-5418 detected with the Fermi Gamma-ray Burst Monitor (GBM) in January 2009, resulting in the largest uniform sample of temporal and spectral properties of SGR J1550-5418 bursts. We have used the combination of broadband and high time-resolution data provided with GBM to perform statistical studies for the source properties. We determine the durations, emission times, duty cycles and rise times for all bursts, and find that they are typical of SGR bursts. We explore various models in our spectral analysis, and conclude that the spectra of SGR J1550-5418 bursts in the 8-200 keV band are equally well described by optically thin thermal bremsstrahlung (OTTB), a power law with an exponential cutoff (Comptonized model), and two black-body functions (BB+BB). In the spectral fits with the Comptonized model we find a mean power-law index of -0.92, close to the OTTB index of -1. We show that there is an anti-correlati...

  15. Origin of the slow afterhyperpolarization and slow rhythmic bursting in striatal cholinergic interneurons.

    Science.gov (United States)

    Wilson, Charles J; Goldberg, Joshua A

    2006-01-01

    Striatal cholinergic interneurons recorded in slices exhibit three different firing patterns: rhythmic single spiking, irregular bursting, and rhythmic bursting. The rhythmic single-spiking pattern is governed mainly by a prominent brief afterhyperpolarization (mAHP) that follows single spikes. The mAHP arises from an apamin-sensitive calcium-dependent potassium current. A slower AHP (sAHP), also present in these neurons, becomes prominent during rhythmic bursting or driven firing. Although not apamin sensitive, the sAHP is caused by a calcium-dependent potassium conductance. It is not present after blockade of calcium current with cadmium or after calcium is removed from the media or when intracellular calcium is buffered with bis-(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid. It reverses at the potassium equilibrium potential. It can be generated by subthreshold depolarizations and persists after blockade of sodium currents by tetrodotoxin. It is slow, being maximal approximately 1 s after depolarization onset, and takes several seconds to decay. It requires >300-ms depolarizations to become maximally activated. Its voltage sensitivity is sigmoidal, with a half activation voltage of -40 mV. We conclude the sAHP is a high-affinity apamin-insensitive calcium-dependent potassium conductance, triggered by calcium currents partly activated at subthreshold levels. In combination with those calcium currents, it accounts for the slow oscillations seen in a subset of cholinergic interneurons exhibiting rhythmic bursting. In all cholinergic interneurons, it contributes to the slowdown or pause in firing that follows driven activity or prolonged subthreshold depolarizations and is therefore a candidate mechanism for the pause response observed in cholinergic neurons in vivo.

  16. Light Dawns on Dark Gamma-ray Bursts

    Science.gov (United States)

    2010-12-01

    Gamma-ray bursts are among the most energetic events in the Universe, but some appear curiously faint in visible light. The biggest study to date of these so-called dark gamma-ray bursts, using the GROND instrument on the 2.2-metre MPG/ESO telescope at La Silla in Chile, has found that these gigantic explosions don't require exotic explanations. Their faintness is now fully explained by a combination of causes, the most important of which is the presence of dust between the Earth and the explosion. Gamma-ray bursts (GRBs), fleeting events that last from less than a second to several minutes, are detected by orbiting observatories that can pick up their high energy radiation. Thirteen years ago, however, astronomers discovered a longer-lasting stream of less energetic radiation coming from these violent outbursts, which can last for weeks or even years after the initial explosion. Astronomers call this the burst's afterglow. While all gamma-ray bursts [1] have afterglows that give off X-rays, only about half of them were found to give off visible light, with the rest remaining mysteriously dark. Some astronomers suspected that these dark afterglows could be examples of a whole new class of gamma-ray bursts, while others thought that they might all be at very great distances. Previous studies had suggested that obscuring dust between the burst and us might also explain why they were so dim. "Studying afterglows is vital to further our understanding of the objects that become gamma-ray bursts and what they tell us about star formation in the early Universe," says the study's lead author Jochen Greiner from the Max-Planck Institute for Extraterrestrial Physics in Garching bei München, Germany. NASA launched the Swift satellite at the end of 2004. From its orbit above the Earth's atmosphere it can detect gamma-ray bursts and immediately relay their positions to other observatories so that the afterglows could be studied. In the new study, astronomers combined Swift

  17. An ecological analysis of the herbivory-elicited JA burst and its metabolism: plant memory processes and predictions of the moving target model.

    Directory of Open Access Journals (Sweden)

    William Stork

    Full Text Available BACKGROUND: Rapid herbivore-induced jasmonic acid (JA accumulation is known to mediate many induced defense responses in vascular plants, but little is known about how JA bursts are metabolized and modified in response to repeated elicitations, are propagated throughout elicited leaves, or how they directly influence herbivores. METHODOLOGY/PRINCIPAL FINDINGS: We found the JA burst in a native population of Nicotiana attenuata to be highly robust despite environmental variation and we examined the JA bursts produced by repeated elicitations with Manduca sexta oral secretions (OS at whole- and within-leaf spatial scales. Surprisingly, a 2(nd OS-elicitation suppressed an expected JA burst at both spatial scales, but subsequent elicitations caused more rapid JA accumulation in elicited tissue. The baseline of induced JA/JA-Ile increased with number of elicitations in discrete intervals. Large veins constrained the spatial spread of JA bursts, leading to heterogeneity within elicited leaves. 1(st-instar M. sexta larvae were repelled by elicitations and changed feeding sites. JA conjugated with isoleucine (JA-Ile translates elicitations into defense production (e.g., TPIs, but conjugation efficiency varied among sectors and depended on NaWRKY3/6 transcription factors. Elicited TPI activity correlated strongly with the heterogeneity of JA/JA-Ile accumulations after a single elicitation, but not repeated elicitations. CONCLUSIONS/SIGNIFICANCE: Ecologically informed scaling of leaf elicitation reveals the contribution of repeated herbivory events to the formation of plant memory of herbivory and the causes and importance of heterogeneity in induced defense responses. Leaf vasculature, in addition to transmitting long-distance damage cues, creates heterogeneity in JA bursts within attacked leaves that may be difficult for an attacking herbivore to predict. Such unpredictability is a central tenet of the Moving Target Model of defense, which posits that

  18. Mitogen-activated protein kinases mediate the oxidative burst and saponin synthesis induced by chitosan in cell cultures of Panax ginseng

    Institute of Scientific and Technical Information of China (English)

    HU Xiangyang; Steven J.NEILL; FANG Jianying; CAI Weiming; TANG Zhangcheng

    2004-01-01

    Chitosan(CHN)specially induced the activities of 39 kD and 42 kD protein kinases in ginseng cells,which could be suppressed by an inhibitor of mitogen-activated protein kinase(MAPK)pathway,PD98059.The immunoprecipitation(IP)using MAPK antibody or kinase assay in vitro also showed that CHN-induced 42 kD and 39 kD protein kinases belonged to the MAPK family.PD98059 suppressed CHN-induced transcriptions of ginseng squalene synthase and ginseng squalene epoxidase genes(gss and gse),CHN-induced accumulation of β-Amyrin synthase(β-AS)and synthesis of saponin.These results showed that CHN-induced activities of MAPKs were necessary for the CHN-induced saponin synthesis.EGTA and LaCI3 suppressed CHN-induced 39 kD and 42 kD MAPK activities.Ruthenium red(RR)could suppress CHN-induced 39 kD activity.All of them suppressed CHN-induced saponin synthesis.These results indicated that CHN-induced increment of cytosolic calcium was necessary for CHN-induced saponin synthesis.PD98059 also suppressed CHN-induced oxidative burst(including the increment of activity of plasma membrane NADPH oxidase and production of H2O2),but diphenylene iodonium(DPI),dimethylthiourea(DMTU)and 2,5-dihydroxycinnamic acid methyl ester(DHC)could not suppress CHN-induced MAPK activities,which indicated that MAPK was possibly function upstream of CHN-induced oxidative burst.

  19. Multiphasic modification of intrinsic functional connectivity of the rat brain during increasing levels of propofol.

    Science.gov (United States)

    Liu, Xiping; Pillay, Siveshigan; Li, Rupeng; Vizuete, Jeannette A; Pechman, Kimberly R; Schmainda, Kathleen M; Hudetz, Anthony G

    2013-12-01

    The dose-dependent effects of anesthetics on brain functional connectivity are incompletely understood. Resting-state functional magnetic resonance imaging (rsfMRI) is widely used to assess the functional connectivity in humans and animals. Propofol is an anesthetic agent with desirable characteristics for functional neuroimaging in animals but its dose-dependent effects on rsfMRI functional connectivity have not been determined. Here we tested the hypothesis that brain functional connectivity undergoes specific changes in distinct neural networks at anesthetic depths associated with loss of consciousness. We acquired spontaneous blood oxygen level-dependent (BOLD) signals simultaneously with electroencephalographic (EEG) signals from rats under steady-state, intravenously administered propofol at increasing doses from light sedation to deep anesthesia (20, 40, 60, 80, and 100 mg/kg/h IV). Power spectra and burst suppression ratio were calculated from the EEG to verify anesthetic depth. Functional connectivity was determined from the whole brain correlation of BOLD data in regions of interest followed by a segmentation of the correlation maps into anatomically defined regional connectivity. We found that propofol produced multiphasic, dose dependent changes in functional connectivity of various cortical and subcortical networks. Cluster analysis predicted segregation of connectivity into two cortical and two subcortical clusters. In one cortical cluster (somatosensory and parietal), the early reduction in connectivity was followed by transient reversal; in the other cluster (sensory, motor and cingulate/retrosplenial), this rebound was absent. The connectivity of the subcortical cluster (brainstem, hippocampal and caudate) was strongly reduced, whereas that of another (hypothalamus, medial thalamus and n. basalis) did not. Subcortical connectivity increased again in deep anesthesia associated with EEG burst suppression. Regional correlation analysis confirmed the

  20. Bursting and spiking due to additional direct and stochastic currents in neuron models

    Institute of Scientific and Technical Information of China (English)

    Yang Zhuo-Qin; Lu Qi-Shao

    2006-01-01

    Neurons at rest can exhibit diverse firing activities patterns in response to various external deterministic and random stimuli, especially additional currents. In this paper, neuronal firing patterns from bursting to spiking, induced by additional direct and stochastic currents, are explored in rest states Corresponding to two values of the parameter VK in the Chay neuron system. Three cases are considered by numerical simulation and fast/slow dynamic analysis, in which only the direct current or the stochastic current exists, or the direct and stochastic currents coexist. Meanwhile, several important bursting patterns in neuronal experiments, such as the period-1 "circle/homoclinic" bursting and the integer multiple "fold/homoclinic" bursting with one spike per burst, as well as the transition from integer multiple bursting to period-1 "circle/homoclinic" bursting and that from stochastic "Hopf/homoclinic" bursting to "Hopf/homoclinic" bursting, are investigated in detail.

  1. The Identification of Two Different Spectral Types of Pulses in Gamma-Ray Bursts

    Science.gov (United States)

    Pendleton, G. N. (Editor); Paciesas, W. S. (Editor); Briggs, M. S. (Editor); Preece, R. D. (Editor); Mallozzi, R. S. (Editor); Meegan, C. A. (Editor); Horack, J. M. (Editor); Fishman, G. J. (Editor); Band, D. L. (Editor); Matteson, J. L. (Editor); Skelton, R. T. (Editor); Hakkila, J. (Editor); Ford, L. A. (Editor); Kouveliotou, C. (Editor); Koshut, T. M. (Editor)

    1997-01-01

    It is shown in this study that two different types of spectral emission are generally produced in gamma-ray bursts. A subset of bursts is identified that exhibits a marked lack of fluence above 300 keV, and these bursts are shown to have luminosities about an order of magnitude lower than bursts with significant fluence above 300 keV. The bursts lacking emission above 300 keV exhibit an effectively homogeneous intensity distribution. In addition, it is shown that both types of emission are common in many bursts, demonstrating that a single source object is capable of generating both of them. These results strongly favor a gamma-ray burst source object that produces two different types of emission with varying degrees of superposition. The impact of this behavior is strong enough that it affects the properties of the burst intensity distribution, as well as the burst spectral characteristics.

  2. Study on Monitoring Rock Burst through Drill Pipe Torque

    Directory of Open Access Journals (Sweden)

    Zhonghua Li

    2015-01-01

    Full Text Available This paper presents a new method to identify the danger of rock burst from the response of drill pipe torque during drilling process to overcome many defects of the conventional volume of drilled coal rubble method. It is based on the relationship of rock burst with coal stress and coal strength. Through theoretic analysis, the change mechanism of drill pipe torque and the relationship of drill pipe torque with coal stress, coal strength, and drilling speed are investigated. In light of the analysis, a new device for testing drill pipe torque is developed and a series of experiments is performed under different conditions; the results show that drill pipe torque linearly increases with the increase of coal stress and coal strength; the faster the drilling speed, the larger the drill pipe torque, and vice versa. When monitoring rock burst by drill pipe torque method, the index of rock burst is regarded as a function in which coal stress index and coal strength index are principal variables. The results are important for the forecast of rock burst in coal mine.

  3. High-Energy Spectral Signatures in $\\gamma$-Ray Bursts

    CERN Document Server

    Baring, M G

    1999-01-01

    One of the principal results obtained by the EGRET experiment aboard the Compton Gamma-Ray Observatory (CGRO) was the detection of several Gamma-ray bursts (GRBs) above 100 MeV. The broad-band spectra obtained for these bursts gave no indication of any high energy spectral attenuation that might preclude detection of bursts by ground-based Cerenkov telescopes (ACTs), thus motivating several TeV observational programs. This paper explores the expectations for the spectral properties in the TeV and sub-TeV bands for bursts, in particular how attenuation of photons by pair creation internal to the source modifies the spectrum to produce distinctive spectral signatures. The energy of spectral breaks and the associated spectral indices provide valuable information that can constrain the bulk Lorentz factor of the GRB outflow at a given time. These characteristics define palpable observational goals for ACT programs, and strongly impact the observability of bursts in the TeV band.

  4. Prevention and forecasting of rock burst hazards in coal mines

    Institute of Scientific and Technical Information of China (English)

    DOU Lin-ming; LU Cai-ping; MU Zong-long; GAO Ming-shi

    2009-01-01

    Rock bursts signify extreme behavior in coal mine strata and severely threaten the safety of the lives of miners, as well as the effectiveness and productivity of miners. In our study, an elastic-plastic-brittle model for the deformation and failure of coal/rock was established through theoretical analyses, laboratory experiments and field testing, simulation and other means, which perfectly predict sudden and delayed rock bursts. Based on electromagnetic emission (EME), acoustic emission (AE) and microseism (MS) effects in the process from deformation until impact rupture of coal-rock combination samples, a multi-parameter identification of premonitory technology was formed, largely depending on these three forms of emission. Thus a system of classification for forecasting rock bursts in space and time was established. We have presented the intensity weakening theory for rock bursts and a strong-soft-strong (3S) structural model for controlling the impact on rock surrounding roadways, with the objective of laying a theoretical foundation and establishing references for parameters for the weakening control of rock bursts. For the purpose of prevention, key technical parameters of directional hydraulic fracturing are revealed. Based on these results, as well as those from deep-hole controlled blasting in coal seams and rock, integrated control techniques were established and anti-impact hydraulic props, suitable for roadways subject to hazards from rockbursts have also been developed. These technologies have been widely used in most coal mines in China, subject to these hazards and have achieved remarkable economic and social benefits.

  5. Broadband Spectral Investigations of SGR J1550-5418 Bursts

    CERN Document Server

    Lin, Lin; Baring, Matthew G; Granot, Jonathan; Kouveliotou, Chryssa; Kaneko, Yuki; van der Horst, Alexander; Gruber, David; von Kienlin, Andreas; Younes, George; Watts, Anna L; Gehrels, Neil

    2012-01-01

    We present the results of our broadband spectral analysis of 42 SGR J1550-5418 bursts simultaneously detected with the Swift/X-ray Telescope (XRT) and the Fermi/Gamma-ray Burst Monitor (GBM), during the 2009 January active episode of the source. The unique spectral and temporal capabilities of the XRT Windowed Timing mode have allowed us to extend the GBM spectral coverage for these events down to the X-ray domain (0.5-10 keV). Our earlier analysis of the GBM data found that the SGR J1550-5418 burst spectra were described equally well with a Comptonized model or with two blackbody functions; the two models were statistically indistinguishable. Our new broadband (0.5 - 200 keV) spectral fits show that, on average, the burst spectra are better described with two blackbody functions than with the Comptonized model. Thus, our joint XRT/GBM analysis clearly shows for the first time that the SGR J1550-5418 burst spectra might naturally be expected to exhibit a more truly thermalized character, such as a two-blackbo...

  6. A Type II Radio Burst without a Coronal Mass Ejection

    CERN Document Server

    Su, W; Ding, M D; Chen, P F; Sun, J Q

    2015-01-01

    Type II radio bursts are thought to be a signature of coronal shocks. In this paper, we analyze a short-lived type II burst that started at 07:40 UT on 2011 February 28. By carefully checking white-light images, we find that the type II radio burst is not accompanied by a coronal mass ejection, only with a C2.4 class flare and narrow jet. However, in the extreme-ultraviolet (EUV) images provided by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO), we find a wave-like structure that propagated at a speed of $\\sim$ 600 km s$^{-1}$ during the burst. The relationship between the type II radio burst and the wave-like structure is in particular explored. For this purpose, we first derive the density distribution under the wave by the differential emission measure (DEM) method, which is used to restrict the empirical density model. We then use the restricted density model to invert the speed of the shock that produces the observed frequency drift rate in the dynamic spectrum. The ...

  7. An internally consistent gamma ray burst time history phenomenology

    Science.gov (United States)

    Cline, T. L.

    1985-01-01

    A phenomenology for gamma ray burst time histories is outlined. Order of their generally chaotic appearance is attempted, based on the speculation that any one burst event can be represented above 150 keV as a superposition of similarly shaped increases of varying intensity. The increases can generally overlap, however, confusing the picture, but a given event must at least exhibit its own limiting characteristic rise and decay times if the measurements are made with instruments having adequate temporal resolution. Most catalogued observations may be of doubtful or marginal utility to test this hypothesis, but some time histories from Helios-2, Pioneer Venus Orbiter and other instruments having one-to several-millisecond capabilities appear to provide consistency. Also, recent studies of temporally resolved Solar Maximum Mission burst energy spectra are entirely compatible with this picture. The phenomenology suggested here, if correct, may assist as an analytic tool for modelling of burst processes and possibly in the definition of burst source populations.

  8. Solar cosmic ray bursts and solar neutrino fluxes

    Science.gov (United States)

    Basilevakaya, G. A.; Nikolsky, S. I.; Stozhkov, Y. I.; Charakhchyan, T. N.

    1985-01-01

    The neutrino flux detected in the C1-Ar experiment seems to respond to the powerful solar cosmic ray bursts. The ground-based detectors, the balloons and the satellites detect about 50% of the bursts of soalr cosmic ray generated on the Sun's visible side. As a rule, such bursts originate from the Western side of the visible solar disk. Since the solar cosmic ray bursts are in opposite phase withthe 11-year galactic cosmic ray cycle which also seems to be reflected by neutrino experiment. The neutrino generation in the bursts will flatten the possible 11-year behavior of the AR-37 production rate, Q, in the Cl-Ar experiment. The detection of solar-flare-generated gamma-quanta with energies above tens of Mev is indicative of the generation of high-energy particles which in turn may produce neutrinos. Thus, the increased Q during the runs, when the flare-generated high energy gamma-quanta have been registered, may be regarded as additional evidence for neutrino geneation in the solar flare processes.

  9. Importance of greenstick lamina fractures in low lumbar burst fractures

    Science.gov (United States)

    Ersozlu, S.; Aydinli, U.

    2006-01-01

    Lumbar burst fractures (L3–L5) represent a small percentage of all spinal fractures. The treatment of fractures involving the lumbar spine has been controversial. Lamina fractures may be complete or of the greenstick type. Dural tears and nerve root entrapment may accompany these lamina fractures. The aim of this retrospective study was to determine the incidence of dural tear in patients who had lumbar burst fractures with greenstick lamina fractures and the importance of these lamina fractures when choosing the optimum treatment. Twenty-six patients with 28 lumbar burst fractures were treated from 1995 through 2002. The average follow-up was 60 months (range 32–110 months). The male to female ratio was 21:5 and the mean age was 37 years (17–64). Dural tear was detected in seven (25%) out of 28 burst fractures. The functional outcome of the entire study group was assessed using the Smiley-Webster Scale. Good to excellent results were obtained in 24 (92%) of 26 patients. Lumbar burst fractures with greenstick lamina fractures occur mostly in the L2–L4 area. In the surgical treatment, any reduction manoeuvre will close the fracture and crush the entrapped neural elements. Therefore, it may be better to explore the greenstick lamina fracture whether there is any neural entrapment or not, before any reduction manoeuvre is attempted. PMID:16501977

  10. The "Musical Emotional Bursts": a validated set of musical affect bursts to investigate auditory affective processing.

    Science.gov (United States)

    Paquette, Sébastien; Peretz, Isabelle; Belin, Pascal

    2013-01-01

    The Musical Emotional Bursts (MEB) consist of 80 brief musical executions expressing basic emotional states (happiness, sadness and fear) and neutrality. These musical bursts were designed to be the musical analog of the Montreal Affective Voices (MAV)-a set of brief non-verbal affective vocalizations portraying different basic emotions. The MEB consist of short (mean duration: 1.6 s) improvisations on a given emotion or of imitations of a given MAV stimulus, played on a violin (10 stimuli × 4 [3 emotions + neutral]), or a clarinet (10 stimuli × 4 [3 emotions + neutral]). The MEB arguably represent a primitive form of music emotional expression, just like the MAV represent a primitive form of vocal, non-linguistic emotional expression. To create the MEB, stimuli were recorded from 10 violinists and 10 clarinetists, and then evaluated by 60 participants. Participants evaluated 240 stimuli [30 stimuli × 4 (3 emotions + neutral) × 2 instruments] by performing either a forced-choice emotion categorization task, a valence rating task or an arousal rating task (20 subjects per task); 40 MAVs were also used in the same session with similar task instructions. Recognition accuracy of emotional categories expressed by the MEB (n:80) was lower than for the MAVs but still very high with an average percent correct recognition score of 80.4%. Highest recognition accuracies were obtained for happy clarinet (92.0%) and fearful or sad violin (88.0% each) MEB stimuli. The MEB can be used to compare the cerebral processing of emotional expressions in music and vocal communication, or used for testing affective perception in patients with communication problems.

  11. The Musical Emotional Bursts: A validated set of musical affect bursts to investigate auditory affective processing.

    Directory of Open Access Journals (Sweden)

    Sébastien ePaquette

    2013-08-01

    Full Text Available The Musical Emotional Bursts (MEB consist of 80 brief musical executions expressing basic emotional states (happiness, sadness and fear and neutrality. These musical bursts were designed to be the musical analogue of the Montreal Affective Voices (MAV – a set of brief non-verbal affective vocalizations portraying different basic emotions. The MEB consist of short (mean duration: 1.6 sec improvisations on a given emotion or of imitations of a given MAV stimulus, played on a violin (n:40 or a clarinet (n:40. The MEB arguably represent a primitive form of music emotional expression, just like the MAV represent a primitive form of vocal, nonlinguistic emotional expression. To create the MEB, stimuli were recorded from 10 violinists and 10 clarinetists, and then evaluated by 60 participants. Participants evaluated 240 stimuli (30 stimuli x 4 [3 emotions + neutral] x 2 instruments by performing either a forced-choice emotion categorization task, a valence rating task or an arousal rating task (20 subjects per task; 40 MAVs were also used in the same session with similar task instructions. Recognition accuracy of emotional categories expressed by the MEB (n:80 was lower than for the MAVs but still very high with an average percent correct recognition score of 80.4%. Highest recognition accuracies were obtained for happy clarinet (92.0% and fearful or sad violin (88.0% each MEB stimuli. The MEB can be used to compare the cerebral processing of emotional expressions in music and vocal communication, or used for testing affective perception in patients with communication problems.

  12. A search for fast radio bursts associated with gamma-ray bursts

    Energy Technology Data Exchange (ETDEWEB)

    Palaniswamy, Divya; Wayth, Randall B.; Trott, Cathryn M.; Tingay, Steven J.; Reynolds, Cormac [International Centre for Radio Astronomy Research, Curtin University, Bentley, WA 6102 (United States); McCallum, Jamie N., E-mail: divya.palaniswamy@postgrad.curtin.edu.au [University of Tasmania, Hobart, Tasmania, 7001 (Australia)

    2014-07-20

    The detection of seven fast radio bursts (FRBs) has recently been reported. FRBs are short duration (∼1 ms), highly dispersed radio pulses from astronomical sources. The physical interpretation for the FRBs remains unclear but is thought to involve highly compact objects at cosmological distance. It has been suggested that a fraction of FRBs could be physically associated with gamma-ray bursts (GRBs). Recent radio observations of GRBs have reported the detection of two highly dispersed short duration radio pulses using a 12 m radio telescope at 1.4 GHz. Motivated by this result, we have performed a systematic and sensitive search for FRBs associated with GRBs. We have observed five GRBs at 2.3 GHz using a 26 m radio telescope located at the Mount Pleasant Radio Observatory, Hobart. The radio telescope was automated to rapidly respond to Gamma-ray Coordination Network notifications from the Swift satellite and slew to the GRB position within ∼140 s. The data were searched for pulses up to 5000 pc cm{sup –3} in dispersion measure and pulse widths ranging from 640 μs to 25.60 ms. We did not detect any events ≥6σ. An in depth statistical analysis of our data shows that events detected above 5σ are consistent with thermal noise fluctuations only. A joint analysis of our data with previous experiments shows that previously claimed detections of FRBs from GRBs are unlikely to be astrophysical. Our results are in line with the lack of consistency noted between the recently presented FRB event rates and GRB event rates.

  13. Bifurcation structure of a model of bursting pancreatic cells

    DEFF Research Database (Denmark)

    Mosekilde, Erik; Lading, B.; Yanchuk, S.;

    2001-01-01

    One- and two-dimensional bifurcation studies of a prototypic model of bursting oscillations in pancreatic P-cells reveal a squid-formed area of chaotic dynamics in the parameter plane, with period-doubling bifurcations on one side of the arms and saddle-node bifurcations on the other....... The transition from this structure to the so-called period-adding structure is found to involve a subcritical period-doubling bifurcation and the emergence of type-III intermittency. The period-adding transition itself is not smooth but consists of a saddle-node bifurcation in which (n + 1)-spike bursting...... behavior is born, slightly overlapping with a subcritical period-doubling bifurcation in which n-spike bursting behavior loses its stability....

  14. Keck Observations of 160 Gamma-Ray Burst Host Galaxies

    CERN Document Server

    Perley, Daniel A; Prochaska, Jason X

    2013-01-01

    We present a preliminary data release from our multi-year campaign at Keck Observatory to study the host galaxies of a large sample of Swift-era gamma-ray bursts via multi-color ground-based optical imaging and spectroscopy. With over 160 targets observed to date (and almost 100 host detections, most of which have not previously been reported in the literature) our effort represents the broadest GRB host survey to date. While targeting was heterogeneous, our observations span the known diversity of GRBs including short bursts, long bursts, spectrally soft GRBs (XRFs), ultra-energetic GRBs, X-ray faint GRBs, dark GRBs, SN-GRBs, and other sub-classes. We also present a preview of our database (currently available online via a convenient web interface) including a catalog of multi-color photometry, redshifts and line ID's. Final photometry and reduced imaging and spectra will be available in the near future.

  15. A novel optical burst switching architecture for high speed networks

    Institute of Scientific and Technical Information of China (English)

    Amit Kumar Garg; R. S. Kaler

    2008-01-01

    A novel optical burst switching (OBS) high speed network architecture has been proposed. To verify its feasibility and evaluate its performance, just-enough-time (JET) signaling has been considered as a high performance protocol. In the proposed architecture, to avoid burst losses, firstly, a short-priorconfirrnation-packet (SPCP) is sent over the control channel that simulates the events that the actual packet will experience. Once SPCP detects a drop at any of the intermediate nodes, the actual packet is not sent but the process repeats. In order to increase network utilization, cost effectiveness and to overcome some limitations of conventional OBS, inherent codes (e.g., orthogonal optical codes (OOC)),which are codified only in intensity, has been used. Through simulations, it shows that a decrease in burst loss probability, cost effectiveness and a gain in processing time are obtained when optical label processing is used as compared with electronic processing.

  16. Radio Bursts with Extragalactic Spectral Characteristics Show Terrestrial Origins

    CERN Document Server

    Burke-Spolaor, Sarah; Ekers, Ronald; Macquart, Jean-Pierre; Crawford, Fronefield

    2010-01-01

    Three years ago, the report of a solitary radio burst was thought to be the first discovery of a rare, impulsive event of unknown extragalactic origin (Lorimer et al. 2007). The extragalactic interpretation was based on the swept-frequency nature of the event, which followed the dispersive delay expected from an extragalactic pulse. We report here on the detection of 16 pulses, the bulk of which exhibit a frequency sweep with a shape and magnitude resembling the Lorimer Burst. These new events were detected in a sidelobe of the Parkes Telescope and are of clearly terrestrial origin, with properties unlike any known sources of terrestrial broad-band radio emission. The new detections cast doubt on the extragalactic interpretation of the original burst, and call for further sophistication in radio-pulse survey techniques to identify the origin of the anomalous terrestrial signals and definitively distinguish future extragalactic pulse detections from local signals. The ambiguous origin of these seemingly disper...

  17. Modeling the redshift and energy distributions of fast radio bursts

    Science.gov (United States)

    Cao, Xiao-Feng; Xiao, Ming; Xiao, Fei

    2017-02-01

    Fast radio bursts (FRBs) are one of the most mysterious astronomical phenomena nowadays. The identification of their origin requires more observations in the future and, importantly, deep understandings of the existing observational data. By fitting the redshift and energy distributions of 15 Parkes FRBs, we try to derive their intrinsic energy function and the cosmic evolution of their burst rates. Specifically, while the energy function is assumed as usual to have a single-power-law form, the burst rates are considered to be proportional to the cosmic star formation rates by a redshift-dependent coefficient. Some plausible fittings are obtained, which indicate the power-law assumptions are feasible and effective. The values of the power-law indices could be used to independently constrain candidate FRB models, although parameter degeneracies still exist.

  18. Optical telescope BIRT in ORIGIN for gamma ray burst observing

    DEFF Research Database (Denmark)

    Content, Robert; Sharples, Ray; Page, Mathew J.

    2012-01-01

    The ORIGIN concept is a space mission with a gamma ray, an X-ray and an optical telescope to observe the gamma ray bursts at large Z to determine the composition and density of the intergalactic matter in the line of sight. It was an answer to the ESA M3 call for proposal. The optical telescope i...... length. All 3 instruments use the same 2k x 2k detector simultaneously so that telescope pointing and tip-tilt control of a fold mirror permit to place the gamma ray burst on the desired instrument without any other mechanism. © 2012 SPIE.......The ORIGIN concept is a space mission with a gamma ray, an X-ray and an optical telescope to observe the gamma ray bursts at large Z to determine the composition and density of the intergalactic matter in the line of sight. It was an answer to the ESA M3 call for proposal. The optical telescope...

  19. Search for Gravitational-Wave Bursts from Soft Gamma Repeaters

    Science.gov (United States)

    Abbott, B.; Abbott, R.; Adhikari, R.; Ajith, P.; Allen, B.; Allen, G.; Amin, R.; Anderson, S. B.; Anderson, W. G.; Arain, M. A.; Araya, M.; Armandula, H.; Armor, P.; Aso, Y.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Ballmer, S.; Bantilan, H.; Barish, B. C.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barton, M. A.; Bartos, I.; Bastarrika, M.; Bayer, K.; Betzwieser, J.; Beyersdorf, P. T.; Bilenko, I. A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, K.; Blackburn, L.; Blair, D.; Bland, B.; Bodiya, T. P.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Brinkmann, M.; Brooks, A.; Brown, D. A.; Brunet, G.; Bullington, A.; Buonanno, A.; Burmeister, O.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Camp, J. B.; Cannizzo, J.; Cannon, K.; Cao, J.; Cardenas, L.; Casebolt, T.; Castaldi, G.; Cepeda, C.; Chalkley, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Christensen, N.; Clark, D.; Clark, J.; Cokelaer, T.; Conte, R.; Cook, D.; Corbitt, T.; Coyne, D.; Creighton, J. D. E.; Cumming, A.; Cunningham, L.; Cutler, R. M.; Dalrymple, J.; Danzmann, K.; Davies, G.; Debra, D.; Degallaix, J.; Degree, M.; Dergachev, V.; Desai, S.; Desalvo, R.; Dhurandhar, S.; Díaz, M.; Dickson, J.; Dietz, A.; Donovan, F.; Dooley, K. L.; Doomes, E. E.; Drever, R. W. P.; Duke, I.; Dumas, J.-C.; Dupuis, R. J.; Dwyer, J. G.; Echols, C.; Effler, A.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, T.; Fairhurst, S.; Fan, Y.; Fazi, D.; Fehrmann, H.; Fejer, M. M.; Finn, L. S.; Flasch, K.; Fotopoulos, N.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V. V.; Fyffe, M.; Garofoli, J.; Gholami, I.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Goda, K.; Goetz, E.; Goggin, L.; González, G.; Gossler, S.; Gouaty, R.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Grimaldi, F.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, E. K.; Gustafson, R.; Hage, B.; Hallam, J. M.; Hammer, D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.; Harstad, E.; Hayama, K.; Hayler, T.; Heefner, J.; Heng, I. S.; Hennessy, M.; Heptonstall, A.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hosken, D.; Hough, J.; Huttner, S. H.; Ingram, D.; Ito, M.; Ivanov, A.; Johnson, B.; Johnson, W. W.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kamat, S.; Kanner, J.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D. G.; Khalili, F. Ya.; Khan, R.; Khazanov, E.; Kim, C.; King, P.; Kissel, J. S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R. K.; Kozak, D.; Kozhevatov, I.; Krishnan, B.; Kwee, P.; Lam, P. K.; Landry, M.; Lang, M. M.; Lantz, B.; Lazzarini, A.; Lei, M.; Leindecker, N.; Leonhardt, V.; Leonor, I.; Libbrecht, K.; Lin, H.; Lindquist, P.; Lockerbie, N. A.; Lodhia, D.; Lormand, M.; Lu, P.; Lubiński, M.; Lucianetti, A.; Lück, H.; Machenschalk, B.; Macinnis, M.; Mageswaran, M.; Mailand, K.; Mandic, V.; Márka, S.; Márka, Z.; Markosyan, A.; Markowitz, J.; Maros, E.; Martin, I.; Martin, R. M.; Marx, J. N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McHugh, M.; McIntyre, G.; McIvor, G.; McKechan, D.; McKenzie, K.; Meier, T.; Melissinos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C. J.; Meyers, D.; Miller, J.; Minelli, J.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Mohanty, S.; Moreno, G.; Mossavi, K.; Mowlowry, C.; Mueller, G.; Mukherjee, S.; Mukhopadhyay, H.; Müller-Ebhardt, H.; Munch, J.; Murray, P.; Myers, E.; Myers, J.; Nash, T.; Nelson, J.; Newton, G.; Nishizawa, A.; Numata, K.; O'Dell, J.; Ogin, G.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Ottens, R. S.; Overmier, H.; Owen, B. J.; Pan, Y.; Pankow, C.; Papa, M. A.; Parameshwaraiah, V.; Patel, P.; Pedraza, M.; Penn, S.; Perreca, A.; Petrie, T.; Pinto, I. M.; Pitkin, M.; Pletsch, H. J.; Plissi, M. V.; Postiglione, F.; Principe, M.; Prix, R.; Quetschke, V.; Raab, F.; Rabeling, D. S.; Radkins, H.; Rainer, N.; Rakhmanov, M.; Ramsunder, M.; Rehbein, H.; Reid, S.; Reitze, D. H.; Riesen, R.; Riles, K.; Rivera, B.; Robertson, N. A.; Robinson, C.; Robinson, E. L.; Roddy, S.; Rodriguez, A.; Rogan, A. M.; Rollins, J.; Romano, J. D.; Romie, J.; Route, R.; Rowan, S.; Rüdiger, A.; Ruet, L.; Russell, P.; Ryan, K.; Sakata, S.; Samidi, M.; de La Jordana, L. Sancho; Sandberg, V.; Sannibale, V.; Saraf, S.; Sarin, P.; Sathyaprakash, B. S.; Sato, S.; Saulson, P. R.; Savage, R.; Savov, P.; Schediwy, S. W.; Schilling, R.; Schnabel, R.; Schofield, R.; Schutz, B. F.; Schwinberg, P.; Scott, S. M.; Searle, A. C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Shawhan, P.; Shoemaker, D. H.; Sibley, A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A. M.

    2008-11-01

    We present a LIGO search for short-duration gravitational waves (GWs) associated with soft gamma ray repeater (SGR) bursts. This is the first search sensitive to neutron star f modes, usually considered the most efficient GW emitting modes. We find no evidence of GWs associated with any SGR burst in a sample consisting of the 27 Dec. 2004 giant flare from SGR 1806-20 and 190 lesser events from SGR 1806-20 and SGR 1900+14. The unprecedented sensitivity of the detectors allows us to set the most stringent limits on transient GW amplitudes published to date. We find upper limit estimates on the model-dependent isotropic GW emission energies (at a nominal distance of 10 kpc) between 3×1045 and 9×1052 erg depending on waveform type, detector antenna factors and noise characteristics at the time of the burst. These upper limits are within the theoretically predicted range of some SGR models.

  20. Size of the top jet drop produced by bubble bursting

    CERN Document Server

    Ghabache, Elisabeth

    2016-01-01

    As a bubble bursts at a liquid-air interface, a tiny liquid jet rises and can release the so-called \\textit{jet drops}. In this paper, the size of the top jet drop produced by a bubble bursting is investigated experimentally. We determine, and discuss, the first scaling law enabling the determination of the top jet drop size as a function of the corresponding mother bubble radius and the liquid properties (viscosity, surface tension, density), along with its regime of existence. Furthermore, in the aim of decoupling experimentally the effects of bubble collapse and jet dynamics on the drop detachment, we propose a new scaling providing the top drop size only as a function of the jet velocity and liquid parameters. In particular, this allows us to untangle the intricate roles of viscosity, gravity and surface tension in the \\textit{end-pinching} of the bubble bursting jet.