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Sample records for burke md phd

  1. BURKING: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Durga Prasad

    2014-08-01

    Full Text Available Homicide means causing death of a person by another person. This homicide may be lawful or unlawful. There are many ways of committing a homicide. Burking is one of the methods. The term ‘Burking’ is derived from notorious criminal ‘Burke’, who with his accomplice ‘Hare’, killed old people by a combination of smothering and traumatic asphyxia, and sold the bodies to the medical school in Edinburgh. We here presented a case of homicide by burking. AIM: To explain the term burking and to present a real case of homicide by burking, which we encountered. MATERIALS & METHODS: Various journal articles, textbooks of Forensic Medicine, FIR copy of the case, crime scene visit, photos, inquest report, post mortem examination, crime investigation information. CONCLUSION: Burking is a type of homicide by smothering with traumatic asphyxia. Though it is rare, it is not completely unseen

  2. Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later.

    Science.gov (United States)

    Koniaris, Leonidas G; Cheung, Michael C; Garrison, Gwen; Awad, William M; Zimmers, Teresa A

    2010-04-01

    Producing and retaining physician-scientists remains a major challenge in advancing innovation, knowledge, and patient care across all medical disciplines. Various programs during medical school, including MD-PhD programs, have been instituted to address the need for continued production of physician-scientists. From 1971 through 1989, 508 students with a prior PhD in the sciences, mathematics, or engineering graduated in two years from an accelerated MD program at the University of Miami School of Medicine. The program, designed to address potential clinical physician shortages rather than physician-scientist shortages, quickly attracted many top-notch scientists to medicine. Many program graduates went to top-tier residencies, pursued research careers in academic medicine, and became academic leaders in their respective fields. A retrospective examination of graduates conducted in 2008-2009 demonstrated that approximately 59% took positions in academic university medical departments, 3% worked for governmental agencies, 5% entered industry as researchers or executives, and 33% opted for private practice. Graduates' positions included 85 full professors, 11 university directors or division heads, 14 academic chairs, 2 medical school deans, and 1 astronaut. Overall, 30% of graduates had obtained National Institutes of Health funding after completing the program. These results suggest that accelerated medical training for accomplished scientists can produce a large number of successful physician-scientists and other leaders in medicine. Furthermore, these results suggest that shortening the medical portion of combined MD-PhD programs might also be considered. PMID:20354390

  3. Teaching Burke Using Advertisements.

    Science.gov (United States)

    Larson, Charles U.

    Kenneth Burke's concepts of identification, the five terms of dramatism, and strategic uses of ambiguity can be successfully taught to undergraduates if appropriate and familiar examples are used. Print and electronic advertising offer the instructor an up-to-date, familiar, and abundant source of classroom examples. Market segmentation models…

  4. Obituary: Edward W. Burke, Jr. (1924-2011)

    Science.gov (United States)

    Bloomer, Raymond, Jr.

    2011-12-01

    Dr. Edward W. Burke Jr. passed away on June 15, 2011, after suffering a heart attack. Dr. Burke devoted his professional life to the research and teaching of physics and astronomy at King College in Bristol, Tennessee. Edward W. Burke, Jr., was born in Macon, Georgia, on September 16, 1924. He was a Navy veteran, having been commissioned as an ensign in 1944. He served in the Pacific near the end of World War II. He proceeded to complete his undergraduate degree in mathematics from Presbyterian College in 1947 and pursued the M.S. and Ph.D. in physics (1949 and 1954, respectively) at the University of Wisconsin. Under the direction of Professor Julian Mack, his thesis was titled "Isotope Shift in the Spectra of Boron." Although he did research in atomic spectra in the early part of his career, his interest in astronomy and variable stars in particular were his primary interests during his long academic career. Dr. Burke began his illustrious career at King College in 1949. He initiated the astronomy program there in 1950, included constructing a 12.5 inch Newtonian telescope, homemade as was most everything in those days. Many of his students learned about photometry at the Burke Observatory on the college campus. Burke was known for his trips to the Kitt Peak and Lowell observatories accompanied by undergraduate students on his trips, all of which were made by automobile which he preferred over flying. His initial interest in Ap stars later broadened into variable and especially eclipsing binary stars. His motivation was maintained by his desire to have his students experience basic research and to spark their interest in advanced degrees. Numerous students achieved advanced science and medical degrees because of Burke's encouragement and mentoring. In 1959, Dr. Burke was awarded a Fulbright professorship and traveled to Chile where he taught physics for a year in the Engineering School at the University of Chile in Santiago. He worked to establish a physics

  5. Rhetorical distance and knowledge in Burke's blurring of identification and division

    DEFF Research Database (Denmark)

    Kampf, Constance

    Development in the academy can be seen as a continuing act of reducing rhetorical distance between the individual scholar's knowledge and accepted knowledge shared in discourse communities through identification as discussed by Burke (1969).  This accepted knowledge can be understood in terms of...... the personal, reductive language process inherent in terministic screens offers an opening to reflect on both the definition and evaluation of knowledge creation processes in Ph.d. education. Although entitlement and terministic screens appear to be opposing processes, they can be understood to...

  6. Interrogating Joe Burke and His Legacy: The Joseph Burke Lecture 2005

    OpenAIRE

    Jaynie Anderson

    2011-01-01

    Art history’s history in Melbourne began with the appointment of Joseph Burke (1913-1992) to the Herald Chair of Fine Arts in 1946. Burke made a number of remarkable appointments with Ursula Hoff, Franz Phillip, and Bernard Smith to create the seminal department of art history in Australia. Burke’s real field of expertise was in the English eighteenth century. Like many intellectuals of the diaspora, he transposed his scholarship to a different society. This article is based on Burke’s corres...

  7. Synecdoche against Metonymy: Burke, Freire, and Writing Instruction.

    Science.gov (United States)

    Hunter, Paul

    1990-01-01

    Argues that the metaphor of writing as a tool is still used because the ideas of Kenneth Burke have not been applied comprehensively. Argues further that Burke's "A Grammar of Motives" implies a radical change in what it means to teach students to analyze and produce texts--a change leading up to and beyond Freireian pedagogy. (RS)

  8. Peter Elbow, Kenneth Burke, and the Idea of Magic.

    Science.gov (United States)

    Briggs, John C.

    1991-01-01

    Asserts that the works of Peter Elbow and Kenneth Burke are valuable reference points because they problematize fundamental assumptions within the field of composition that pluralism and factional perspectives typically elide. Describes Elbow's rhetorical magic and shows how magic illuminates Burke's effort. Wonders whether Elbow and Burke…

  9. Kuidas kirjutatakse ajalugu? / Peter Burke ; interv. Marek Tamm, tlk. Ainiki Väljataga

    Index Scriptorium Estoniae

    Burke, Peter

    2007-01-01

    Renessansiajastu kultuuriloost, keelest sotsiaalajaloo uurimisobjektina ning ajalookirjutuse ajaloost ja teooriast Cambridge'i Ülikooli kultuuriajaloo emeriitprofessoti P. Burke'i teostes. Varem ilm.: Burke, Peter. Kultuuride kohtumine : esseid uuest kultuuriajaloost. Tallinn, 2006. Lk. 275-286

  10. "Verbal Atom Cracking": Burke and a Rhetoric of Reading.

    Science.gov (United States)

    Enos, Theresa

    "Verbal atom cracking," according to Kenneth Burke, entails a process where the reader reconstructs what the writer has constructed--a necessary process before the reader can begin deconstructing. Foregrounding opposites, rather than looking for apposites, may not be the best way to approach discourse that covers especially esoteric…

  11. Burke, Nietzsche, Lacan: Three Perspectives on the Rhetoric of Order.

    Science.gov (United States)

    Thomas, Douglas

    1993-01-01

    Examines the complex relationship between rhetoric and order in the works of Kenneth Burke, Friedrich Nietzsche, and Jacques Lacan. Argues for three differing, yet complementary, views of rhetoric and order, each having a corresponding epistemology and axiology. Concludes with an analysis of the construction of order in Thomas Hobbe's "Leviathan."…

  12. Division, Unity, and Consciousness Raising: Burke and Ong on Technology.

    Science.gov (United States)

    Palmeri, Anthony J.

    In an effort to contribute to the dialogue on the effects of the intensification of technology upon the structure and dynamics of human communication, this paper examines the views of technology in the works of Kenneth Burke and Walter Ong. The paper argues that their theories can be compatible, that Ong's view of writing as a technology which…

  13. "The Piety of Degradation": Kenneth Burke, the Bureau of Social Hygiene, and "Permanence and Change"

    Science.gov (United States)

    Jack, Jordynn

    2004-01-01

    Kenneth Burke's employment with the Bureau of Social Hygiene informed his rhetorical theory in the 1930s. Between 1926 and 1930, Burke researched criminology and drug addiction and ghostwrote a book for Colonel Arthur Woods, "Dangerous Drugs". An investigation of archives indicates that this research left its mark on Burke's "Permanence and…

  14. Traditionalism and modern subjectivity: Enlightenment and conservatism of Edmund Burke

    Directory of Open Access Journals (Sweden)

    Nikitović Aleksandar

    2003-01-01

    Full Text Available The issue of traditionalism versus modern subjectivism in the light of the conflict of Edmund Burke`s conservatism with the Enlightenment as the ideological basis of the French revolution was not discussed or studied sufficiently in our political and philosophical theory. In this paper we are reconsidering a theoretical debate between arising modern rationalism of Enlightenment and European traditionalism. The text further explains on the reasons for choosing this subject and course the research will take subsequently. An overview is provided of the most important topics as well as a preliminary conception of the problem structure in this research. Considering the importance and overwhelming influence exhorted by French revolution it is only logical that the event of such magnitude met not only with approvals but with challenges and disputes as well, and all of it contributed to the theoretical considerations of the historical sense and purpose of this event. The aim of the project is to provide explanations and evaluations of the origins Enlightenment on one hand side and theoretically reconsidered traditionalism on the other. Looking at the dawn of modern era and evaluating these events would cast sharper light on the spirit of times of this crucial moment of history, and it would provide new basis for reconsideration of the achievements and implications of the fundamental ideas of Moderna.

  15. "More Than Lessons in How To Read": Burke, Freud, and the Resources of Symbolic Transformation.

    Science.gov (United States)

    Quandahl, Ellen

    2001-01-01

    Argues that Kenneth Burke used "The Interpretation of Dreams," as well as other works by Sigmund Freud, as a lesson on reading, taking over the central tropes of dreamwork and making them broadly dialectical rather than strictly psychoanalytic terms. Suggests that Freud's "tropology" of dreaming is crucial for reading Burke. (SG)

  16. ATLAS PHd Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  17. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  18. Dynamic response of a pulsed Burke-Schumann diffusion flame

    Science.gov (United States)

    Sheu, Jyh-Cherng; Stocker, Dennis P.; Chen, Lea-Der

    1995-01-01

    Turbulent flames are often envisioned as an ensemble of random vortices interacting with the combustion process. A better understanding of the vortex-flame interactions therefore would be useful in improving the modeling of turbulent diffusion flames. Substantial simplification may be made by investigating controlled interactions in a laminar flame, as opposed to random interactions in a turbulent flame. The general goals of the research project are to improve our understanding of (1) the influence of buoyancy on co-flow diffusion flames and (2) the effects of buoyancy on vortex-flame interactions in co-flow diffusion flames. As a first step toward objective (2), we conducted a joint experimental and numerical investigation of the vortex-flame interaction. Vortices were produced by mechanically pulsing the fuel flow at a low frequency, e.g., 10 Hz. Experiments were conducted using a nonflickering Burke-Schumann flame in both microgravity (mu-g) and normal gravity (1g) as a means of varying the buoyant force without modification of the pressure (i.e., density). The effects of buoyant convection may then be determined by a comparison of the mu-g and 1g results. The mu-g results may also reveal the important mechanisms which are masked or overwhelmed by buoyant convection in 1g. A numerical investigation was conducted using a validated, time-accurate numerical code to study the underlying physics during the flame interaction and to assist the interpretation of the experimental results.

  19. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  20. Ph.D. shortage

    Science.gov (United States)

    The late 1990s will see a shortage of Ph.D. graduates, according to the Association of American Universities, Washington, D.C. AAU's new comprehensive study, “The Ph.D. Shortage: The Federal Role,” reports that competition for new Ph.D.s is already intense and can only intensify because demand is greater than supply in both academic and nonacademic markets.Doctoral education plays an increasingly important role in U.S. research and development programs. Students have a pivotal part in doing research and enriching it with new ideas. The AAU report says that graduate students are “major determinants of the creativity and productivity of U.S. academic research, the source of more than 50% of the nation's basic research.’ The market for doctoral education extends beyond the university. In 1985, about 43% of all Ph.D.s employed in this country were working outside higher education; the demand for doctorate recipients in nonacademic sectors continues to grow.

  1. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation.......Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  2. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003

  3. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  4. One Hundred Years of Reading Research: Successes and Missteps of Edmund Burke Huey and Other Pioneers

    Science.gov (United States)

    Walczyk, Jeffrey J.; Tcholakian, Talar; Igou, Frank; Dixon, Alexa P.

    2014-01-01

    For more than 100 years, research on the psychology of reading has proliferated. In this article, the authors wish to help modern reading researchers understand the origins of the discipline and benefit from its history. This article draws heavily on Edmund Burke Huey's 1908 landmark volume "The Psychology and Pedagogy of Reading,"…

  5. 78 FR 50109 - Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Science.gov (United States)

    2013-08-16

    ... cultural items listed in this notice meet the definition of unassociated funerary objects. Lineal... repatriate cultural items under the control of the Burke Museum, Seattle, WA, that meet the definition of... Lisk families occupied the property. The Lisk family was of Kikiallus heritage. The site described...

  6. 75 FR 52023 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-08-24

    ..., University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. Notice is here... Washington State Museum (Burke Museum), University of Washington, Seattle, WA. The human remains were removed..., Takelman, Molalan, Sahaptin, Salishan, and Shastan language families. In 1855, the U.S. Government...

  7. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  8. BurkDiff: A Real-Time PCR Allelic Discrimination Assay for Burkholderia Pseudomallei and B. mallei

    OpenAIRE

    Bowers, Jolene R.; Engelthaler, David M.; Jennifer L Ginther; Talima Pearson; Peacock, Sharon J.; Apichai Tuanyok; Wagner, David M.; Currie, Bart J.; Keim, Paul S.

    2010-01-01

    A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a ro...

  9. BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei.

    Directory of Open Access Journals (Sweden)

    Jolene R Bowers

    Full Text Available A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei.

  10. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  11. Contending for liberty : principle and party in Montesquieu, Hume, and Burke

    OpenAIRE

    Elliott, Sean

    2010-01-01

    This thesis explores the political reformation of “faction” in the political thought of Montesquieu, David Hume, and Edmund Burke, three thinkers whose works span what Pierre Manent calls “an exquisite moment of liberalism.” It examines the transformation of faction from one based largely on class to one based largely on political function and argues that as the political emphasis of “party” overtook that of class, a disconnect in constitutional theory appeared between the principles formerl...

  12. Burke Porter研发的三机器人轮胎生产线

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Burke E Porter机械公司(BEPCO)已研制出专利产品TRIOBO系统——进行皂洗和装配轮胎的三机器人工作间概念。此系统将成为推动此类技术发展的催化剂。TRIOBO独有的特性是它仅用三个机器人,每个机器人都完成不同的功能:

  13. [Professor Andelko Wolf, MD, PhD. (1922-2007), eminent epidemiologist and dermatovenerologist].

    Science.gov (United States)

    Gruber, Franjo; Peris, Zdravko

    2009-01-01

    Professor Andelko Wolf graduated medicine from the University of Zagreb School of Medicine in 1947. First he specialised in epidemiology and became head of the Brucellosis Centre in Rijeka for the Istria region. Later he also specialised in dermatovenerology at the Department for Skin and Venereal diseases in Rijeka. He passed the specialty board exam in dermatovenerology in 1958 and became teaching assistant. In 1973, he became assistant professor and in 1981 full professor. At the Department he founded the Laboratory for Mycology and allergology. Later he focused on occupational skin diseases and photodermatology. His doctoral thesis was on the action of light on the skin. He chaired the Clinic and was a member of various Hospital and Medical School committees. He was an excellent clinician undergraduate and graduate student teacher in Rijeka and Zagreb. He published around eighty papers on dermatology, but also on the necessity to reform medical studies. PMID:20500011

  14. In Remembrance of Robert J. Arceci, M.D., Ph.D. | Office of Cancer Genomics

    Science.gov (United States)

    It is with great sadness and a profound sense of loss that OCG recognizes the untimely passing of Dr. Robert J. Arceci. Dr. Arceci was a co-Principal Investigator for the Acute Myeloid Leukemia (AML) project within the TARGET initiative, which aims to discover novel, more effective treatments for childhood cancers. Dr. Arceci was passionate about the use of cancer genomics to both inform therapeutic approaches in the clinic and expand the field of precision medicine.

  15. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  16. Urbanism PhD Research 2008 - 2010

    NARCIS (Netherlands)

    Van der Hoeven, F.D.; Brand, N.; Van der Burg, L.; Çalışkan, O.; Tan, E.R.; Wang, C.-Y.; Zhou, J.

    2009-01-01

    To ensure the quality of the Ph.D. research the Department introduced a special procedure for periodic evaluation: after a period of nine months the potential Ph.D. candidates are asked to present their research design, theoretical framework and methodological approach to the members of the Departme

  17. The Main Diseases and Control Measures of Panax notoginseng(Burk) F. H. Chen in Wuzhou City

    Institute of Scientific and Technical Information of China (English)

    Chen; Yinghui; Liu; Zhuowu; Qiu; Weihua; Tan; Xinxing; Li; Jinfeng

    2014-01-01

    The main symptoms of root rot,anthracnose,blight and damping-off of Panax notoginseng( Burk) F. H. Chen are introduced in the paper,and the corresponding control measures are elaborated from the aspects of agricultural management measures,seed disinfection,seedbed treatment and chemical control.

  18. Approaching Corporate Social Responsibility through Kenneth Burke's Notions of Terministic Screens and Entitlement

    DEFF Research Database (Denmark)

    Kampf, Constance

    summarizes Burke's essay, "Antinomies of Definition," from a Grammar of Motives as demonstrating that 'the intrinsic and the extrinsic can change places' "such that to define is always to contextualize and to uncover the absence of a solid ground for a claim to knowledge."2   So if the intrinsic and...... allow for user agency, whereas entitlement appears to be focused more at the cultural level, with the agency shared by the 'tribe,' the language itself, and the context of situation.1 In other words, "terministic screens" appear to be extrinsic, while "entitlement" appears to be intrinsic.  Carmichael...... extrinsic can change places, the interpretive process of "terministic screens" and the constitutive process of "entitlement" may well be reciprocal.  The implications of this reciprocity can be used as a basis for understanding the linguistic and cultural components of Corporate Social Responsibility as...

  19. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  20. Interaction in PhD supervision

    DEFF Research Database (Denmark)

    Kobayashi, Sofie; Grout, Brian William Wilson; Rump, Camilla Østerberg

    This paper contains an analysis of a single supervision session, undertaken with the aim of identifying how learning opportunities might be created for a PhD student. The supervision session concerned methodologies to be employed in a PhD study related to storm water management and included the Ph...... learning opportunity is created for the PhD student as a participant in the academic discussion with her supervisors about the research methodologies. The involvement of multiple supervisors appears to enrich the learning environment and help create learning opportunity....

  1. A workshop on leadership for senior MD-PhD students

    OpenAIRE

    Meador, Catherine B.; Parang, Bobak; Musser, Melissa A.; Haliyur, Rachana; Owens, David A.; Terence S Dermody

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD–PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a hi...

  2. Brenda K. Edwards, PhD

    Science.gov (United States)

    Brenda K. Edwards, PhD, has been with the Surveillance Research Program (SRP) and its predecessor organizations at the National Cancer Institute (NCI) since 1989, serving as SRP’s Associate Director from 1990-2011.

  3. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receivin...

  4. Protein engineering with PHD zinc fingers

    International Nuclear Information System (INIS)

    Full text: The plant homeodomain (PHD) is a protein domain of ∼45-100 residues that is characterised by a Cys4-His-Cys3 zinc-binding motif These domains are found widely in nuclear proteins involved in transcription and seem to have an array of functions. In some instances, PHD domains have been shown to be important in mediating protein-protein interactions. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain can vary greatly in terms of both amino acid composition and length. Given the diversity of functions they fulfill in nature, we propose to use these PHD domains as prototype protein interaction scaffolds for drug design. We have determined the solution structure of the second PHD domain of Mi2 (Mi2-PHD2) by multi-dimensional NMR spectroscopy. The structure shows that Mi2-PHD2 adopts a globular fold in solution and contains a di-metal-binding structural motif with the two zinc ions ligated in an interleaved manner. While this structure is similar to that of other PHD domains, two flexible loop regions can also be observed. These loops may be suitable target regions for protein engineering studies, where novel binding functions could be introduced. To test the stability of the Mi2-PHD2 fold, we have made a number of mutations and insertions in the two loop regions NMR spectra of these mutants show they adopt native-like conformations. We are currently determining the structures of a selection of these mutants and are using a combination of rational and combinatorial methods to introduce new functions

  5. What PhD students really want

    CERN Document Server

    Mao, Minnie

    2010-01-01

    The road to becoming an astronomer is exciting, but often fraught with danger and conflicting messages. A PhD student is inundated with catch-phrases such as "publish or perish" and "it's not about the quantity, but the quality of work". How do we know which advice to follow? How can we publish copious amounts of quality work in only three years so as to maximize our success in the future? How do we even know what "good quality" really is? With only a short time to prepare ourselves for the big wide world of Astronomy, what is the best way for a PhD student to maximize their research and ultimately maximize their success as a real astronomer? The PhD students of today are the astronomers of tomorrow, but their journey depends on a positive work environment in which they can thrive and improve. Here I present the results of a survey of current PhD students on how they believe they can maximize their success in science. I find that PhD students in Australia expect to write more papers during their PhD than is e...

  6. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer

    International Nuclear Information System (INIS)

    Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the development of more aggressive cancers. Hypoxia inducible factor (HIF), a major player in cancerous tissue adaptation to hypoxia, is negatively regulated by the family of prolyl hydroxylase enzymes (PHD1, PHD2, PHD3) and asparaginyl hydroxylase, called factor inhibiting HIF (FIH). PHD1, PHD2, PHD3 and FIH gene expression was evaluated using quantitative RT-PCR and western blotting in primary colonic adenocarcinoma and adjacent histopathologically unchanged colonic mucosa from patients who underwent radical surgical resection of the colon (n = 90), and the same methods were used for assessment of PHD3 gene expression in HCT116 and DLD-1 CRC cell lines. DNA methylation levels of the CpG island in the promoter regulatory region of PHD1, PHD2, PHD3 and FIH were assessed using bisulfite DNA sequencing and high resolution melting analysis (HRM) for patients and HRM analysis for CRC cell lines. We found significantly lower levels of PHD1, PHD2 and PHD3 transcripts (p = 0.00026; p < 0.00001; p < 0.00001) and proteins (p = 0.004164; p = 0.0071; p < 0.00001) in primary cancerous than in histopathologically unchanged tissues. Despite this, we did not observe statistically significant differences in FIH transcript levels between cancerous and histopathologically unchanged colorectal tissue, but we found a significantly increased level of FIH protein in CRC (p = 0.0169). The reduced PHD3 expression was correlated with significantly increased DNA methylation in the CpG island of the PHD3 promoter regulatory region (p < 0.0001). We did not observe DNA methylation in the CpG island of the PHD1, PHD2 or FIH promoter in cancerous and histopathologically unchanged colorectal tissue. We also showed that 5-Aza-2’-deoxycytidine induced DNA demethylation leading to increased PHD3 transcript and protein level in HCT116 cells. We

  7. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  8. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  9. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  10. The extended Perdew-Burke-Ernzerhof functional with improved accuracy for thermodynamic and electronic properties of molecular systems

    OpenAIRE

    Xu, Xin; GODDARD, William A.

    2004-01-01

    Density functional theory (DFT) has become the method of choice for many applications of quantum mechanics to the study of the electronic properties of molecules and solids. Despite the enormous progress in improving the functionals, the current generation is inadequate for many important applications. As part of the quest of finding better functionals, we consider in this paper the Perdew-Burke-Ernzerhof (PBE) functional, which we believe to have the best theoretical foundation, but which le...

  11. Analisis Fungsi Pakaian Karnaval di Yogyakarta Menurut Roland Barthes dan Fungsi Seni Edmund Burke Felmand

    Directory of Open Access Journals (Sweden)

    Deni Setiawan

    2015-08-01

    Full Text Available Carnival clothing is one form of artists creativities in fine art, created in various functions. Those functions are viewed based on utility value and the purpose that consistently are embedded in an art work. In addition, several functions of carnival clothing were constructed on the basis of social and cultural conditions that are effective in a certain place. Each and every type of clothing raises perception to everyone else who sees it. Promotion of fashion style and industry through carnival clothing results in diverse perceptions acceptable to the viewers. Audiences perceptions are also not apart from the key functions, social ones, and the physical ones of those carnival clothings themselves. Those three functions are the common ones of each art work created as communication tool with everyone else. The carnival clothings are communication tools of the fashion designer to the customers, communication between one customer and another one. On the carnival clothing there are also sources of knowledge science, history, technology, and many other explainable meanings. Through carnival clothings, the detectable issues in physical and non-physical structures are identifiable as well as they play role as the space to make more exploration on the dynamics of a community culture. This article aims to answer the functions of carnival clothing, using aesthetic approach, through the theory of clothing functions Roland Barthes and Edmund Burke Feldmans art functions.

  12. Interview with Di Gao PhD

    Directory of Open Access Journals (Sweden)

    Di Gao

    2016-04-01

    Full Text Available Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP to support USP monograph modernization and since June 2014 she has been working in her current position at AstraZeneca. Recently, she won a prestigious award from Women in Bio (WIB. WIB is an organization of professionals committed to promoting careers, leadership and entrepreneurship for women in the life sciences. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  13. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  14. Interview with Di Gao PhD

    OpenAIRE

    Di Gao

    2016-01-01

    Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP) to support USP monograph modernization and since June 2014 she has been working in her current p...

  15. Gaussian Mixture PHD Filtering with Variable Probability of Detection

    OpenAIRE

    Hendeby, Gustaf; Karlsson, Rickard

    2014-01-01

    The probabilistic hypothesis density (PHD) filter has grown in popularity during the last decade as a way to address the multi-target tracking problem. Several algorithms exist; for instance under linear-Gaussian assumptions, the Gaussian mixture PHD (GM-PHD) filter. This paper extends the GM-PHD filter to the common case with variable probability of detection throughout the tracking volume. This allows for more efficient utilization, e.g., in situations with distance dependent probability of...

  16. Contenido de los nutrientes básicos en Catolaccus grandis Burks criados sobre larvas del picudo del algodon Basic nutrients content of Catolaccus grandis Burks reared in cotton boll weevil larvae

    OpenAIRE

    LÚCIA HELENA AVELINO ARAUJO; ANTONIO ALVAREZ GUERRA; ENRIQUE ARANDA HERRERA

    2000-01-01

    El objetivo del trabajo fue determinar los niveles de carbohidratos, proteínas solubles y aminoácidos libres de larvas, pupas hembras y adultos hembras de Catolaccus grandis (Burks) (Hymenoptera: Pteromalidae) criados sobre larvas del picudo del algodón envenenadas por hembras del parasitoide y por larvas de primer instar del parasitoide. Esto estudio fue conducido en la Unidade de Investigación de Control Biologico de Plagas del Departamento de Agricultura de los Estados Unidos de la América...

  17. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  18. Estudio fitoquímico de flores de Geoffroea decorticans (Gill. ex Hook. et Arm.) Burk, Leguminoseae (Fabaceae)

    OpenAIRE

    Silva, Raúl Alejandro; López de Ruiz, Rosa Evelia; Ruiz, Sohar Osvaldo

    2004-01-01

    Geoffroea decorticans (Gill ex Hook et Arn) Burk. Leguminoseae (Fabaceae), de nombre común "chañar" o "chañarcillo", es un árbol o arbusto de amplia distribución en la República Argentina y se usa en la medicina popular por sus virtudes emolientes, balsámicas, antitusivas y expectorantes. Aplicando la técnica de extracción con solventes de polaridad creciente fue posible aislar e identificar en la fracción soluble en éter de petróleo seis componentes. A su vez en la fracción solub...

  19. Contenido de los nutrientes básicos en Catolaccus grandis Burks criados sobre larvas del picudo del algodon

    OpenAIRE

    ARAUJO LÚCIA HELENA AVELINO; GUERRA ANTONIO ALVAREZ; ARANDA HERRERA ENRIQUE

    2000-01-01

    El objetivo del trabajo fue determinar los niveles de carbohidratos, proteínas solubles y aminoácidos libres de larvas, pupas hembras y adultos hembras de Catolaccus grandis (Burks) (Hymenoptera: Pteromalidae) criados sobre larvas del picudo del algodón envenenadas por hembras del parasitoide y por larvas de primer instar del parasitoide. Esto estudio fue conducido en la Unidade de Investigación de Control Biologico de Plagas del Departamento de Agricultura de los Estados Unidos de la América...

  20. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  1. Harvesting graphics power for MD simulations

    OpenAIRE

    Meel, van, C.S.; Arnold, A; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU’s is compared to their main processor counterpart. We achieve speedups of up to 40, 80 and 150 fold, respectively. With the...

  2. Harvesting graphics power for MD simulations

    OpenAIRE

    2008-01-01

    Abstract We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU's is compared to their main processor counterpart. We achieve speedups of up to 80, 40 and 150 fold, re...

  3. ProtoMD: A Prototyping Toolkit for Multiscale Molecular Dynamics

    OpenAIRE

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2013-01-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates `GROMACS wrapper' to initiate MD simula...

  4. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  5. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  6. 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd International Conference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent ...

  7. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  8. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  9. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  10. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  11. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    OpenAIRE

    Kunstman, John W.; Longo, Walter E

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the n...

  12. The Reframing of Methodology: Revisiting a PhD Study

    OpenAIRE

    Sarah Dubberley

    2014-01-01

    The paper draws on a PhD study to explore some methodological dilemmas associated with the execution of qualitative research when framed within positivist study design. The PhD was linked to an externally funded research project which evaluated the implementation of a custody-based intervention in the secure estate. While the PhD was conceived as a qualitative study, informed by interpretivist methodology and associated epistemology, the wider funded study was informed by positivist tradition...

  13. Pursuit of the Ph.D.

    Directory of Open Access Journals (Sweden)

    Scott P. Kerlin

    1995-11-01

    Full Text Available he thesis is put forward that changes in public policy which originally promoted broad access to higher education are leading to the diminished likelihood that minorities, those from low-income backgrounds and females in underrepresented disciplines will pursue, or be able to complete, the doctorate. By reviewing a wide range of research literature and statistical reports on the status of doctoral education in the U.S. & Canada, a detailed sociological portrait of those who pursue the Ph.D. is presented. Recommendations are given for further research on doctoral education, particularly in areas of attrition,retention, student indebtedness, social stratification, and post-doctoral career plans.

  14. Understanding Non-Traditional PhD Students Habitus--Implications for PhD Programmes

    Science.gov (United States)

    Naidoo, Devika

    2015-01-01

    Against the background of vast changes in doctoral education and the emergence of non-traditional doctoral programmes, this paper investigates the habitus of non-traditional PhD students at a South African university. Bourdieu's conceptual tool of habitus informed the study. In-depth and open-ended interviews were conducted with 10 non-traditional…

  15. Janet Quinn, RN, PhD. Therapeutic touch and a healing way. Interview by Bonnie Horrigan.

    Science.gov (United States)

    Quinn, J

    1996-07-01

    Janet Quinn, RN, PhD, is an associate professor and senior scholar at the Center for Human Caring at the School of Nursing, University of Colorado Health Sciences Center, in Denver, Colo. In addition to teaching she conducts research, lectures, writes, and maintains a private practice in Boulder, Colo. She received her PhD in nursing research and theory development from New York University in 1982. Quinn is a member of Sigma Theta Tau, and is active in a diverse group of professional organizations including the American Nurses Association, American Holistic Nurses Association, Association for Holotropic Breathwork International, Association for Transpersonal Psychology, International Society for the Study of Subtle Energy and Energy Medicine, Hakomi Therapy Association, and the Institute of Noetic Sciences. During her career she has received many awards including the Healers Award from the Nurse Healers and Professional Associates (1995); the Edgar S Wilson, MD, Fellowship Award from the International Society for the Study of Subtle Energies and Energy Medicine (1994); and the Holistic Nurse of the Year award from the American Holistic Nurses Association. Alternative Therapies interviewed Dr Quinn at her office in Boulder, Colo. PMID:8795925

  16. Peter Burke, Hibridismo Cultural, Ediciones Akal, Madrid, 2010 (Trad. Sandra Chaparro Martínez) 158 p.

    OpenAIRE

    Brower Beltramin, Jorge

    2012-01-01

    Peter Burke, uno de los historiadores de la cultura más notables de las últimas décadas,  nos entrega en este texto,  un ensayo teórico iluminador y sugerente en torno a uno de los fenómenos frecuentemente analizados en estos tiempos de globalización: el hibridismo cultural. Antes de referirnos a la arquitectura conceptual de este magnífico ensayo teórico es necesario hacer una referencia al estudio preliminar realizado por la profesora María José  del Río Barredo para la edición en español d...

  17. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD....

  18. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  19. Predicting Computer Science Ph.D. Completion: A Case Study

    Science.gov (United States)

    Cox, G. W.; Hughes, W. E., Jr.; Etzkorn, L. H.; Weisskopf, M. E.

    2009-01-01

    This paper presents the results of an analysis of indicators that can be used to predict whether a student will succeed in a Computer Science Ph.D. program. The analysis was conducted by studying the records of 75 students who have been in the Computer Science Ph.D. program of the University of Alabama in Huntsville. Seventy-seven variables were…

  20. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  1. Research Collaboration and Commercialization: The PhD Candidate Perspective

    Science.gov (United States)

    Dooley, Lawrence; Kenny, Breda

    2015-01-01

    This paper explores PhD students' perceptions of their entrepreneurial and commercial capabilities, their attitude towards university supports and the extent to which they engage in external collaboration. The study concentrated on current PhD researchers at one university in Ireland as a unit of analysis and provides encouraging evidence from the…

  2. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  3. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  4. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  5. Ante Šiljeg, PhD in Interdisciplinary Sciences

    Directory of Open Access Journals (Sweden)

    Sanja Lozić

    2013-12-01

    Full Text Available Ante Šiljeg defended his doctoral thesis The Digital Relief Model in Analysis of Geomorphometric Parameters – Example of PP Vrana Lake at Faculty of Science, University of Zagreb on June 20th, 2013 (supervisor Sanja Lozić, PhD, assistant professor and received a PhD degree in the field of interdisciplinary science, field of geography, branch of applied geography. Doctoral thesis was defended in front of committee composed of Mladen Pahernik, PhD, assistant professor, Danijel Orešić, PhD, associate professor and Aleksandar Toskić, PhD, associate professor. Commitee for disertation review was in the same composition.

  6. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent o...

  7. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  8. 75 FR 69862 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2010-11-16

    ... exist or develop on other helicopters of the same type design. Therefore, this AD requires, within 4...-AD. Applicability: Model MD900 helicopters, with lower main rotor hub (hub), part number 900R2101008... the main rotor hub (hub) for a crack. If a crack is found, this AD requires, before further...

  9. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2011-07-15

    ... helicopters of this same type design. AD Requirements This AD requires a visual inspection, and if necessary...) Inspect the main rotor lower hub assembly for a crack by following the specified portions of MD Helicopter... rotor lower hub assembly (lower hub) for a crack, and if you find a crack, before further...

  10. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  11. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  12. Contenido de los nutrientes básicos en Catolaccus grandis Burks criados sobre larvas del picudo del algodon

    Directory of Open Access Journals (Sweden)

    ARAUJO LÚCIA HELENA AVELINO

    2000-01-01

    Full Text Available El objetivo del trabajo fue determinar los niveles de carbohidratos, proteínas solubles y aminoácidos libres de larvas, pupas hembras y adultos hembras de Catolaccus grandis (Burks (Hymenoptera: Pteromalidae criados sobre larvas del picudo del algodón envenenadas por hembras del parasitoide y por larvas de primer instar del parasitoide. Esto estudio fue conducido en la Unidade de Investigación de Control Biologico de Plagas del Departamento de Agricultura de los Estados Unidos de la América, en Weslaco, Texas. Las 20 muestras de cada uno de los tres estados de desarrollo: tercer instar larval, pupas hembra y adultos hembra del parasitoide C. grandis, fueron separadas y pesadas individualmente y se cuantió el contenido de carbohidratos totales, proteínas solubles totales y aminoácidos libres criados en diferentes sustratos. Los resultados obtenidos confirman la existencia de patrones metabólicos significativamente distintos de estos nutrientes básicos.

  13. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    Directory of Open Access Journals (Sweden)

    Armand Faganel

    2008-09-01

    Full Text Available The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent of the applicants were accepted. Another interesting thing was the competitive approach towards the conference, which means that only the best articles will be published in the conference proceedings.

  14. Ecological Agriculture Research: Increasing Competence through PhD Courses.

    Science.gov (United States)

    Lieblein, G.; Francis, C. A.; Salomonsson, L.; Sriskandarajah, N.

    1999-01-01

    A Ph.D. course in ecological agriculture included a weeklong intensive workshop and individual research projects. The course demonstrated the usefulness of multiple approaches to learning research methods and perspectives and increased networking among researchers. (SK)

  15. A Gaussian Mixture PHD Filter for Extended Target Tracking

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2010-01-01

    In extended target tracking, targets potentially produce more than one measurement per time step. Multiple extended targets are therefore usually hard to track, due to the resulting complex data association. The main contribution of this paper is the implementation of a Probability Hypothesis Density (PHD) filter for tracking of multiple extended targets. A general modification of the PHD filter to handle extended targets has been presented recently by Mahler, and the novelty in this work lie...

  16. Information behaviour and practices of PhD students

    OpenAIRE

    Drachen, Thea Marie; Larsen, Asger Væring; Gullbekk, Eystein; Westbye, Hilde; Lach, Karin

    2011-01-01

    This report addresses the information behaviour and practices of PhD students and its implications for library services. Academic libraries and their services are part of the information network of PhD students. Therefore libraries should pay special attention to the needs and practices of this important academic subgroup. The University Librarian at Copenhagen University Library and Information Service (CULIS) commissioned this study. It was conducted by representatives from CULIS, Universit...

  17. Making data in PhD dissertations reusable for research

    OpenAIRE

    Schöpfel, Joachim; Prost, Hélène; Malleret, Cécile

    2015-01-01

    How can an academic library contribute to make data submitted together with PhD dissertations useful for further research? Our paper provides some recommendations for information professionals, based on a review of studies and projects and on empirical evidence from a content analysis of data sources and types from 300 print and digital dissertations in social sciences and humanities (1987-2013) and a survey on data management conducted with the scientists and PhD students of the University o...

  18. 78 FR 35773 - Airworthiness Directives; MD Helicopters, Inc. (MDHI), Helicopters

    Science.gov (United States)

    2013-06-14

    ... the MDHI Model MD900 helicopters with certain main rotor blade (MRB) retention bolts (bolts) installed... MD 900 helicopters with a main rotor blade retention bolt (bolt), part number (P/N) 900R3100001-103... exist or develop on other products of the same type design. Related Service Information We have...

  19. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  20. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter...

  1. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  2. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  3. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  4. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  5. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2008-02-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astronomy and astrophysics. The average new astronomer might expect to hold up to 3 jobs before finding a steady position.

  6. Cubature Information SMC-PHD for Multi-Target Tracking.

    Science.gov (United States)

    Liu, Zhe; Wang, Zulin; Xu, Mai

    2016-01-01

    In multi-target tracking, the key problem lies in estimating the number and states of individual targets, in which the challenge is the time-varying multi-target numbers and states. Recently, several multi-target tracking approaches, based on the sequential Monte Carlo probability hypothesis density (SMC-PHD) filter, have been presented to solve such a problem. However, most of these approaches select the transition density as the importance sampling (IS) function, which is inefficient in a nonlinear scenario. To enhance the performance of the conventional SMC-PHD filter, we propose in this paper two approaches using the cubature information filter (CIF) for multi-target tracking. More specifically, we first apply the posterior intensity as the IS function. Then, we propose to utilize the CIF algorithm with a gating method to calculate the IS function, namely CISMC-PHD approach. Meanwhile, a fast implementation of the CISMC-PHD approach is proposed, which clusters the particles into several groups according to the Gaussian mixture components. With the constructed components, the IS function is approximated instead of particles. As a result, the computational complexity of the CISMC-PHD approach can be significantly reduced. The simulation results demonstrate the effectiveness of our approaches. PMID:27171088

  7. The Production Rate and Employment of Ph.D. Astronomers

    CERN Document Server

    Metcalfe, Travis S

    2007-01-01

    In an effort to promote self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astr...

  8. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  9. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  10. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  11. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  12. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  13. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  14. Antioxidant, Antiproliferative, and Pro-Apoptotic Activities of a Saponin Extract Derived from the Roots of Panax notoginseng (Burk.) F.H. Chen

    OpenAIRE

    He, Nian-Wu; Yan ZHAO; Guo, Ling; Shang, Jun; Yang, Xing-Bin

    2012-01-01

    Dietary and medicinal uses of Panax notoginseng have been associated with reduced risk of cancer. This study was designed to investigate the profiles of P. notoginseng saponin extract (PNSE), the major bioactive ingredients in P. notoginseng (Burk.) F.H. Chen, by high-performance liquid chromatography, and, for the first time, the anticancer effect of PNSE in the human colon cancer cell line LoVo was further evaluated. The major saponins present in PNSE were ginsenosides Rg1 (31.1%) and Rb1 (...

  15. An analysis of Ph.D. examiners' reports in engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-03-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003 and 2010 for a total of 1220 Australian Ph.D. theses by analysing examiner reports. Our analysis indicates that Ph.D. theses in engineering, N = 106, differ considerably from those in other fields in areas such as gender of candidates and examiners and the examiners' geographical location. We also found that assessment areas such as significance and contribution of the thesis, publications arising from the thesis, breadth, depth and recency of the literature review and communication and editorial correctness are areas in which the proportion of text of engineering examiners' comments differs significantly from other fields.

  16. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  17. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  18. The Production Rate and Employment of Ph.D. Astronomers

    OpenAIRE

    Metcalfe, Travis S.

    2007-01-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated wit...

  19. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    their thesis work and receive constructive feedback from experts in the field as well as from peers. Also it is an opportunity for researchers to get an insight into new research topics in the field. Ph.D. students at any stage of their doctoral studies may participate. Seven abstracts were submitted......, theoretic, and practical challenges of testing software systems, including communication protocols, services, distributed platforms, middleware, embedded systems, and security infrastructures. The aims of the ICTSS Doctoral Workshop is to provide a forum for PhD students to present preliminary results and...

  20. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... main design qualities that may improve the patients’ experience of the hospital interior, and in the experimental studies these aesthetic quali- ties are contextualised in empirical studies conducted at two Danish hospitals. Through these different studies, the PhD thesis addresses the technical and...

  1. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  2. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  3. An Analysis of Ph.D. Examiners' Reports in Engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-01-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003…

  4. Measures for Ph.D. Evaluation: The Recruitment Process

    Science.gov (United States)

    D'Agostino, Antonella; Fruzzetti, Stefania; Ghellini, Giulio; Neri, Laura

    2011-01-01

    In the last years the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe. In the wide landscape that involves the entire HE system we draw attention on the third level of its organization, i.e. the Ph.D. In particular, this paper discusses the…

  5. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course of...

  6. PhD by Publication: A Student's Perspective

    Directory of Open Access Journals (Sweden)

    Peter Kanowski

    2008-01-01

    Full Text Available This article presents the first author's experiences as an Australian doctoral student undertaking a PhD by publication in the arena of the social sciences. She published nine articles in refereed journals and a peer-reviewed book chapter during the course of her PhD. We situate this experience in the context of current discussion about doctoral publication practices, in order to inform both postgraduate students and academics in general. The article discusses recent thinking about PhD by publication and identifies the factors that students should consider prior to adopting this approach, in terms of university requirements, supervisors' attitudes, the research subject matter, intellectual property, capacity and working style, and issues of co-authorship. It then outlines our perceptions of the advantages and disadvantages of undertaking a PhD by publication. We suggest that, in general, the advantages outweigh the disadvantages. We conclude by reflecting on how the first author's experiences relate to current discussions about fostering publications by doctoral students.

  7. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2007-05-01

    As in many sciences, the production rate of new Ph.D. astronomers is decoupled from the global demand for trained scientists. As noted by Thronson (1991, PASP, 103, 90), overproduction appears to be built into the system, making the mathematical formulation of surplus astronomer production similar to that for industrial pollution models -- an unintended side effect of the process. Following Harris (1994, ASP Conf., 57, 12), I document the production of Ph.D. astronomers from 1990 to 2005 using the online Dissertation Abstracts database. To monitor the changing patterns of employment, I examine the number of postdoctoral, tenure-track, and other jobs advertised in the AAS Job Register during this same period. Although the current situation is clearly unsustainable, it was much worse a decade ago with nearly 7 new Ph.D. astronomers in 1995 for every new tenure-track job. While the number of new permanent positions steadily increased throughout the late 1990's, the number of new Ph.D. recipients gradually declined. After the turn of the century, the production of new astronomers leveled off, but new postdoctoral positions grew dramatically. There has also been recent growth in the number of non-tenure-track lecturer, research, and support positions. This is just one example of a larger cultural shift to temporary employment that is happening throughout society -- it is not unique to astronomy.

  8. First International Student Obtains His PhD at CAS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Mr. Ghulam Rasul, the first international student formally enrolled by the Graduate University of CAS (GUCAS) has received his PhD degree this summer after having passed his dissertation defense on May 21 at the CAS Institute of Atmospheric Physics (IAP).

  9. Theo Thole as a PhD ''student''

    NARCIS (Netherlands)

    vanDuijnen, PT

    1997-01-01

    Thee Thole's Ph.D. work was the basis for the Direct Reaction Field method for incorporating a semi-classical ''solvent'' in quantum chemical calculations. The early stages of his work and later progress is reviewed and a typical example of his analytical and programming skills, so far unpublished,

  10. Peer Mentorship and Transformational Learning: PhD Student Experiences

    Science.gov (United States)

    Preston, Jane P.; Ogenchuk, Marcella J.; Nsiah, Joseph K.

    2014-01-01

    The purpose of the paper is to describe our peer mentorship experiences and explain how these experiences fostered transformational learning during our PhD graduate program in educational administration. As a literature backdrop, we discuss characteristics of traditional forms of mentorship and depict how our experiences of peer mentorship was…

  11. The 8th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    Each year since 1991 there has been a workshop for PhD students at the ECOOP conference. It is every every year conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS), hence it is an event for PhD students by PhD students. The purpose of the PhDOOS network is to help leverag...

  12. Undertaking Individual Transdisciplinary PhD Research for Sustainable Development: Case Studies from South Africa

    Science.gov (United States)

    van Breda, John; Musango, Josephine; Brent, Alan

    2016-01-01

    Purpose: This paper aims to improve the understanding of individual transdisciplinary PhD research in a developing country context, focusing on three individual PhD case studies in South Africa. Design/Methodology/Approach: Multiple-case method was used, and three completed transdisciplinary PhD research efforts undertaken at the Stellenbosch…

  13. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  14. Detection of haplotype mutations of the MD-2 gene promoter associated with Der p2-induced allergy using a nanostructured biosensor

    Directory of Open Access Journals (Sweden)

    Chin YT

    2014-03-01

    Full Text Available Yu-Ting Chin,1 En-Chih Liao,2 Chia-Che Wu,1 Gou-Jen Wang,1,3,4 Jaw-Ji Tsai2 1Department of Mechanical Engineering, National Chung-Hsing University, 2Department of Medical Education and Research, Taichung Veterans General Hospital, 3Graduate Institute of Biomedical Engineering, 4PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung, Taiwan Abstract: Group 2 allergens (Der p2 have been reported to be a major cause of the human immune response to dust mite allergens. In this study, we have demonstrated for the first time the effective differentiation between haplotype mutation and normal genes in the MD-2 gene promoter using a nanostructured biosensor. A 70-mer gene fragment containing the haplotype of two single nucleotide polymorphisms in the MD-2 gene promoter region was used as a probe to detect haplotype mutations associated with Der p2-induced allergy. Discrimination was achieved using electrochemical impedance spectroscopy. The discrimination experiments employed 30 haplotype mutation samples and 30 normal target samples. The haplotype mutation samples and normal target samples could be clearly discriminated, even using samples produced by a five-cycle polymerase chain reaction process. The time and cost of sample preparation for the polymerase chain reaction process in the clinical setting can thus be reduced. Keywords: haplotype mutation detection, nanostructured biosensor, MD-2 gene promoter, electrochemical impedance spectroscopy

  15. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  16. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  17. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.

    Directory of Open Access Journals (Sweden)

    Wei Wei

    Full Text Available BACKGROUND: Soybean [Glycine max (L. Merr.] is one of the most important crops for oil and protein resource. Improvement of stress tolerance will be beneficial for soybean seed production. PRINCIPAL FINDINGS: Six GmPHD genes encoding Alfin1-type PHD finger protein were identified and their expressions differentially responded to drought, salt, cold and ABA treatments. The six GmPHDs were nuclear proteins and showed ability to bind the cis-element "GTGGAG". The N-terminal domain of GmPHD played a major role in DNA binding. Using a protoplast assay system, we find that GmPHD1 to GmPHD5 had transcriptional suppression activity whereas GmPHD6 did not have. In yeast assay, the GmPHD6 can form homodimer and heterodimer with the other GmPHDs except GmPHD2. The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization. Transgenic Arabidopsis plants overexpressing the GmPHD2 showed salt tolerance when compared with the wild type plants. This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes. SIGNIFICANCE: These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator.

  18. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  19. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  20. Club of Bologna International Best PhD Prize 2012

    Directory of Open Access Journals (Sweden)

    Marco Fiala

    2012-06-01

    Full Text Available The Club of Bologna, in collaboration with UNACOMA, will be awarding a prize for the best PhD theses on subjects related to agricultural machinery design and development. Up to ten theses will be selected and the best five of these will have the chance of being presented during the annual Club of Bologna meeting that will be held from 9 to 10 November 2012, on occasion of the EIMA. The authors of the best three PhD theses will also receive a cash prize. The winners will be guests in Bologna of UNACOMA who will cover travelling expenses and hotel accommodation for 2 nights. They will also meet farm machinery manufacturers attending the international trade fair. The winners of the Club of Bologna Prize 2012 will be announced here. Application forms and further information can be downloaded from the Club of Bologna website (http://www.clubofbologna.org/.

  1. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  2. BURKE, Peter. Uma história social do conhecimento: II: da Enciclopédia à Wikipédia

    OpenAIRE

    Jefferson José Queler

    2014-01-01

    Em meio às discussões atuais sobre a natureza da chamada sociedade do conhecimento, Peter Burke indaga-se sobre os modos de criação do saber, sobretudo no Ocidente, da segunda metade do século XVIII até os dias de hoje. Em seu novo livro, uma continuação de Uma história social do conhecimento: de Gutemberg a Diderot, ele propõe-se a analisar tal assunto desde a publicação da Enciclopédia, como projeto do Iluminismo, até a recente elaboração da Wikipédia. Trata-se de trabalho de historiador ma...

  3. Lynn Sorbara, PhD | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Lynn Sorbara earned her PhD from Albert Einstein College of Medicine in 1986. Her thesis research was in the areas of the mechanism of action of the drug, Taxol, and of multidrug resistance. After postdoctoral fellowships at the Rockefeller University and the Mount Sinai College of Medicine in Manhattan, she came to the NIH as a Senior Staff Fellow in the Diabetes Branch of NIDDK. |

  4. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    OpenAIRE

    Xiaoxi Yan

    2014-01-01

    As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W funct...

  5. Extended Target Tracking Using a Gaussian-Mixture PHD Filter

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2012-01-01

    This paper presents a Gaussian-mixture implementation of the phd filter for tracking extended targets. The exact filter requires processing of all possible measurement set partitions, which is generally infeasible to implement. A method is proposed for limiting the number of considered partitions and possible alternatives are discussed. The implementation is used on simulated data and in experiments with real laser data, and the advantage of the filter is illustrated. Suitable remedies are gi...

  6. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  7. The multisensor PHD filter: II. Erroneous solution via Poisson magic

    Science.gov (United States)

    Mahler, Ronald

    2009-05-01

    The theoretical foundation for the probability hypothesis density (PHD) filter is the FISST multitarget differential and integral calculus. The "core" PHD filter presumes a single sensor. Theoretically rigorous formulas for the multisensor PHD filter can be derived using the FISST calculus, but are computationally intractable. A less theoretically desirable solution-the iterated-corrector approximation-must be used instead. Recently, it has been argued that an "elementary" methodology, the "Poisson-intensity approach," renders FISST obsolete. It has further been claimed that the iterated-corrector approximation is suspect, and in its place an allegedly superior "general multisensor intensity filter" has been proposed. In this and a companion paper I demonstrate that it is these claims which are erroneous. The companion paper introduces formulas for the actual "general multisensor intensity filter." In this paper I demonstrate that (1) the "general multisensor intensity filter" fails in important special cases; (2) it will perform badly in even the easiest multitarget tracking problems; and (3) these rather serious missteps suggest that the "Poisson-intensity approach" is inherently faulty.

  8. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  9. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  10. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  11. MD on Injection Quality – Longitudinal and Transverse Parameters

    CERN Document Server

    Drosdal, L; Bohl, T; Bracco, C; Cornelis, K; Damerau, H; Goddard, B; Kain, V; Meddahi, M

    2011-01-01

    Losses at injection depend on the beam quality in the longitudinal and transverse plane in the injectors. During the MD on the 30th of June to 1st of July, 2011, many parameters in the injectors were de-tuned on purpose to see the effect on injection losses and hence bring some understanding to recurring problems with injection quality during LHC filling. The effect of the 800 MHz in the SPS, radial steering, larger momentum spread at the SPS extraction and many other longitudinal parameters were studied during the MD. The MD showed however that the injection losses are dominated by far by the transverse size of the particle population. If the SPS scrapers are correctly positioned, injection losses are low even at the presence of quality issues in the longitudinal plane. To be able to inject brighter 50 ns beams or eventually 25 ns beams, injection losses with nominal emittances (3.5 m) must still be acceptable. This MD showed that nominal emittances can be injected with similar loss levels as the typical ...

  12. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  13. The Added Value of a PhD in Medicine--PhD Students' Perceptions of Acquired Competences

    Science.gov (United States)

    Anttila, Henrika; Lindblom-Ylänne, Sari; Lonka, Kristi; Pyhältö, Kirsi

    2015-01-01

    PhD in the field of medicine is more common than in any other domain. Many medical doctors are driven towards PhD, but also students with other backgrounds (usually MSc) are conducting a PhD in medical schools. Higher education has invested a lot in developing generic and research competences. Still little is known about how PhD students…

  14. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  15. Developmentally regulated expression of two MADS-box genes, MdMADS3 and MdMADS4, in the morphogenesis of flower buds and fruits in apple.

    Science.gov (United States)

    Sung, S K; Yu, G H; Nam, J; Jeong, D H; An, G

    2000-03-01

    Two MADS-box genes, MdMADS3 and MdMADS4, were isolated from the apple (Malus x domestica Borkh.) cultivar Fuji, and their spatial and temporal expression patterns were studied during morphological differentiation of the flower buds and the fruits. Both MdMADS3 and MdMADS4 showed high sequence similarities to FBP2 from petunia, TM5 from tomato, and AGL2, AGL4 from Arabidopsis. Although MdMADS3 was expressed in the inner three whorls of the floral primordium, its expression was hardly detectable in developing fruit. The second gene, MdMADS4, was ubiquitously expressed in the inflorescence meristem, floral meristem, all four floral organs, and fruit. Moreover, MdMADS4 expression was high in the vascular bundles assigned to the floral tube and the carpellary vascular bundles in fruit at early developmental stages. The MdMADS4 transcript also accumulated in embryos of the developing seeds. These results suggest that MdMADS3 and MdMADS4 are involved in different functions, and that MdMADS4 may function in the important events controlling flower and fruit development. PMID:10787044

  16. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  17. Applied PhD Research in a Work-Based Environment: An Activity Theory-Based Analysis

    Science.gov (United States)

    Granata, S. N.; Dochy, F.

    2016-01-01

    Activity theory is used to compare PhD undertaken at university, that is, academic PhD, with PhD performed in collaboration with industry, that is, semi-industrial PhD. The research is divided into a literature review and a case study. Semi-industrial and academic PhD are modelled as activity systems, and differences are highlighted in terms of…

  18. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    Directory of Open Access Journals (Sweden)

    Wolpert Lewis

    2010-08-01

    Full Text Available Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  19. Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995

    International Nuclear Information System (INIS)

    NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee

  20. [The tribute of the pioneer of hypnotherapy--Franz Anton Mesmer, MD, PhD in the history of psychotherapy and medicine].

    Science.gov (United States)

    Radovancević, Ljubomir

    2009-01-01

    Modern hypnosis started with the Austrian physician Franz Anton Mesmer (1734-1815), who believed that the phenomenon known as mesmerism, or animal magnetism, or fluidum was related to an invisible substance--a fluid that runs within the subject or between the subject and the therapist, that is, the hypnotist, or the "magnetizer". The term hypnosis was introduced in the 1840s by a Scottish surgeon James Braid (1795-1860), who believed the subject to be in a particular state of sleep--a trance. In the late 19th century, a French neurologist Jean Martin Charcot (1825-1893) thought hypnotism to be a special physiological state, and his contemporary Hyppotite-Marie Bernheim (1840-1919) believed it to be a psychological state of heightened suggestibility. Sigmund Freud, who studied with Charcot, used hypnosis early in his career to help patients recover repressed memories. He noted that patients would relive traumatic events while under hypnosis, a process know as abreaction. Freud later replaced hypnosis with the technique of free associations. Today, hypnosis is used as a form of therapy (hypnotherapy), a method of investigation to recover lost memories, and research tool. According to Caplan & Sadock, F.A. Mesmer is generally thought of as the fons et origo of modern psychotherapy; and from the early techniques of mesmerism, it is said, have evolved the more elaborate and sophisticated therapeutic measures of the analyst and his colleagues. Although Mesmer was certainly dealing with individuals suffering from a variety of neurotic disorders, and though the clinical successes he achieved were the result of psychological processes that his procedures induced in his patients, Mesmer's theoretical formulations, his understanding of the nature of the treatment he developed, and his specific procedures were all totally different from those of the 20th century analyst. He was one of the corne stones in the development of psychoanalysis through hypnosis mainly of hysterical patients. PMID:20166775

  1. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    OpenAIRE

    Wolpert Lewis

    2010-01-01

    Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  2. Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists

  3. Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995

    International Nuclear Information System (INIS)

    This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory

  4. Human radiation studies: Remembering the early years. Oral history of Dr. John W. Gofman, M.D., Ph.D., December 20, 1994

    International Nuclear Information System (INIS)

    Dr. John W. Gofman was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE) concerning his research at the University of California, Berkeley and his biomedical work at Lawrence Livermore Radiation Laboratory. Following a short biographical sketch, Dr. Gofman relates his remembrances with the discovery and chemistry of uranium-233, the Manhattan project, laboratory production of the first milligram of plutonium, pre-1945 medical use of high-dosage radiation, medical treatments with phosphorus 32, and fallout. Dr. Gofman also discusses his relationships with Professor Oppenheimer, Joe Hamilton, Ernest Lawrence, and other. Then Dr. Gofman describes his pioneering work on his true interests concerning heart disease, heparin, and lipoproteins. Finally intra-AEC political issues are discussed relating to testing of atomic weapons

  5. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  6. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  7. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  8. MS PHD'S Professional Development Program: A Scientific Renaissance in Cyberspace

    Science.gov (United States)

    Powell, J. M.; Williamson, V. A.; Griess, C. A.; Pyrtle, A. J.

    2004-12-01

    This study is a component of a four-year investigation of MS PHD'S Professional Development Program's virtual community through the lenses of underrepresented minority students in Earth system science and engineering fields. In this presentation, the development, assessment and projected utilization of the ongoing study will be discussed. The overall goal of this study is to examine the effectiveness of virtual team building methods and understand how the development of a communal cyberinfrastructure acts as an integral part of the emergence of a Scientific Renaissance. The exemplar, Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S), provides professional development experiences to facilitate the advancement of students of color achieving outstanding Earth system careers. Undergraduate and graduate students are supported through access to scientific conferences, mentorship and virtual community building. Framed by critical theory, this ethnographic exploration uses a mixed methods research design to record, observe, and analyze both the processes and products of the website, listserv and synchronous web-based dialogue. First, key findings of the formative evaluation and annual reports of the successfully implemented 2003 MS PHD'S Pilot Project are presented. These findings inform future evaluations of the use of technological resources and illustrate how this public space provides peer support and enriched research opportunities. Quantitative methods such as statistical analysis, academic and professional tracking and evaluative tools for scientific content and competency are complimented by qualitative methods that include observations, heuristic case studies and focus group interviews. The findings of this ongoing investigation will provide insight on how national organizations, higher education practitioners, community-based support systems and underrepresented minorities in the sciences promote diversity by developing

  9. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  10. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  11. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  12. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  13. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  14. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  15. Role of PhD Students in the Development of Environmental Engineering Study Programs

    OpenAIRE

    Dzene, I; Jaunzems, D

    2008-01-01

    Since 2000 in Riga Technical University Institute (RTU) of Energy Systems and Environment (IESE) realize study program “Environment science” in two academic levels – bachelor and master degree, but since 2005 – also in environmental engineering PhD level study program. Two main blocks of possibilities of PhD students are research projects and pedagogical activities. PhD students have a significant role and opportunities in development process of environmental engineering study programs as alm...

  16. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  17. Rinaldo Paar, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Zdravko Kapović

    2011-12-01

    Full Text Available Rinaldo Paar defended his PhD thesis Geospatial Databases of Objects in the Highway Management System of the Republic of Croatia at the Faculty of Geodesy, University of Zagreb on 29 June 2010. His thesis supervisor was Prof. Dr. Zdravko Kapović. The Examining Committee comprised Prof. Dr. Gorana Novaković, Prof. Dr. Zdravko Kapović, Prof. Dr. Marko Džapo (all of the Faculty of Geodesy and Prof. Dr. Zlatko Šavor and Prof. Dr. Ljudevit Herceg of the Faculty of Civil Engineering, University of Zagreb.

  18. Andrija Krtalić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2011-12-01

    Full Text Available Andrija Krtalić successfully defended his PhD thesis Decision Support System in Conditions of Uncertainty in Demining Activities Based on Remote Sensing Methods at the Faculty of Geodesy, University of Zagreb on 11 July 2011. The thesis was examined by an Examining Committee composed of Prof. Emer. Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine, Prof. Dr. Renata Pernar (Faculty of Forestry, University of Zagreb, Prof. Dr. Hrvoje Gold (Faculty of Traffic Sciences in Zagreb and Prof. Dr. Milan Bajić (supervisor.

  19. Can maitake MD-fraction aid cancer patients?

    Science.gov (United States)

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2002-06-01

    Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer. PMID:12126464

  20. Review of 40-year MD theses in Medical Oncology

    International Nuclear Information System (INIS)

    Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

  1. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    Science.gov (United States)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  2. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  3. Simulation and Particle-Tracking Analysis of Selected Ground-Water Pumping Scenarios at Vogtle Electric Generation Plant, Burke County, Georgia

    Science.gov (United States)

    Cherry, Gregory S.; Clarke, John S.

    2007-01-01

    The source of ground water to production wells at Vogtle Electric Generation Plant (VEGP), a nuclear power plant in Burke County, Georgia, was simulated under existing (2002) and potential future pumping conditions using an existing U.S. Geological Survey (USGS) MODFLOW ground-water flow model of a 4,455-square-mile area in the Coastal Plain of Georgia and South Carolina. Simulation results for three steady-state pumping scenarios were compared to each other and to a 2002 Base Case condition. The pumping scenarios focused on pumping increases at VEGP resulting from projected future demands and the addition of two electrical-generating reactor units. Scenarios simulated pumping increases at VEGP ranging from 1.09 to 3.42 million gallons per day (Mgal/d), with one of the scenarios simulating the elimination of 5.3 Mgal/d of pumping at the Savannah River Site (SRS), a U.S. Department of Energy facility located across the Savannah River from VEGP. The largest simulated water-level changes at VEGP were for the scenario whereby pumping at the facility was more than tripled, resulting in drawdown exceeding 4-8 feet (ft) in the aquifers screened in the production wells. For the scenario that eliminated pumping at SRS, water-level rises of as much as 4-8 ft were simulated in the same aquifers at SRS. Results of MODFLOW simulations were analyzed using the USGS particle-tracking code MODPATH to determine the source of water and associated time of travel to VEGP production wells. For each of the scenarios, most of the recharge to VEGP wells originated in an upland area near the county line between Burke and Jefferson Counties, Georgia, with none of the recharge originating on SRS or elsewhere in South Carolina. An exception occurs for the scenario whereby pumping at VEGP was more than tripled. For this scenario, some of the recharge originates in an upland area in eastern Barnwell County, South Carolina. Simulated mean time of travel from recharge areas to VEGP wells for the

  4. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  5. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  6. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  7. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  8. I-determinants for a successful PhD or postdoctoral outcome.

    Science.gov (United States)

    Sørensen, Henrik Toft

    2016-01-01

    Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student's skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an "I" and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the personal characteristics of a researcher play a very important role in the quality of research. Application of some of the principles mentioned in this article might allow decision to reach a more evidence-based way to recruit PhD students and postdoctorals. PMID:27574466

  9. Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.

    Science.gov (United States)

    He, Nian-Wu; Zhao, Yan; Guo, Ling; Shang, Jun; Yang, Xing-Bin

    2012-04-01

    Dietary and medicinal uses of Panax notoginseng have been associated with reduced risk of cancer. This study was designed to investigate the profiles of P. notoginseng saponin extract (PNSE), the major bioactive ingredients in P. notoginseng (Burk.) F.H. Chen, by high-performance liquid chromatography, and, for the first time, the anticancer effect of PNSE in the human colon cancer cell line LoVo was further evaluated. The major saponins present in PNSE were ginsenosides Rg1 (31.1%) and Rb1 (34.4%), and the total content of the eight saponins identified (notoginsenoside R1, ginsenosides Rg1, Re, Rb1, Rc, and Rd, and isomeric ginsenosides Rb2 and Rb3) was 81.7%, indicating that it was a highly purified standardized saponin extract. Furthermore, PNSE was found to have a markedly cytotoxic effect and antiproliferative activity against the LoVo cell line in a dose- and time-dependent manner. Flow cytometry analysis demonstrated that PNSE caused cell cycle arrest at S phase. Moreover, PNSE was found to possess antioxidative capacities in the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay and hydroxyl radical scavenging assay in vitro. Taken together, the present results suggest that naturally occurring PNSE may provide significant natural defense against human colon cancer. PMID:22316295

  10. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  11. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode;

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation. This...

  12. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  13. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving the commun...

  14. Delivering an Organizational Leadership PhD Program at a Distance: University of Oklahoma

    Science.gov (United States)

    Rodgers, Joseph Lee; Williams, T. H. Lee

    2011-01-01

    In this chapter, the authors identify and review a number of key features in the successful development and maintenance of a PhD program delivered at a distance. The University of Oklahoma's PhD program in organizational leadership was developed in the early 1990s and delivered (primarily, but not completely) to military personnel and families…

  15. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  16. Multi-Target Detection from Full-Waveform Airborne Laser Scanner Using Phd Filter

    Science.gov (United States)

    Fuse, T.; Hiramatsu, D.; Nakanishi, W.

    2016-06-01

    We propose a new technique to detect multiple targets from full-waveform airborne laser scanner. We introduce probability hypothesis density (PHD) filter, a type of Bayesian filtering, by which we can estimate the number of targets and their positions simultaneously. PHD filter overcomes some limitations of conventional Gaussian decomposition method; PHD filter doesn't require a priori knowledge on the number of targets, assumption of parametric form of the intensity distribution. In addition, it can take a similarity between successive irradiations into account by modelling relative positions of the same targets spatially. Firstly we explain PHD filter and particle filter implementation to it. Secondly we formulate the multi-target detection problem on PHD filter by modelling components and parameters within it. At last we conducted the experiment on real data of forest and vegetation, and confirmed its ability and accuracy.

  17. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

    Directory of Open Access Journals (Sweden)

    Inmaculada Segura

    2016-03-01

    Full Text Available Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs, and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the actin cross-linker filamin A (FLNA as a target of PHD2 mediating these effects. In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL-mediated ubiquitination and proteasomal degradation. In hypoxia, PHD2 inactivation rapidly upregulates FLNA protein levels because of blockage of its proteasomal degradation. FLNA upregulation induces more immature spines, whereas Flna silencing rescues the immature spine phenotype induced by PHD2 inhibition.

  18. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  19. Earth and Space Science PhD Employment Trends

    Science.gov (United States)

    Giesler, J. L.

    2001-05-01

    A recent report by the American Geophysical Union and the American Geological Institute, "Earth and Space Science PhDs, Class of 1999" looked at employment trends of recent graduates. Demographically, our graduates are, as a population, older than those who graduated in any other physical science. While almost one-third of graduates are employed in a different subfield than that of their degree, more than 80% of Earth and space science PhDs secure initial employment in the geosciences. Graduates are finding employment in less than 6 months and the unemployment rate has dropped significantly below that of two years ago. The PhD classes of 1996, 1997, and 1998 had ~ 50% of their graduates taking postdoctoral appointments. In 1999, this declined to only 38% postdocs with an increase in permanent employment in both the education and government sectors. Perception of the job market is improving as well. Respondents are considerably happier than they were in 1996.

  20. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. PMID:26746591

  1. The Virtual Observatory Powered PhD Thesis

    CERN Document Server

    Zolotukhin, Ivan

    2010-01-01

    The Virtual Observatory has reached sufficient maturity for its routine scientific exploitation by astronomers. To prove this statement, here I present a brief description of the complete VO-powered PhD thesis entitled "Galactic and extragalactic research with modern surveys and the Virtual Observatory" comprising 4 science cases covering various aspects of astrophysical research. These comprize: (1) homogeneous search and measurement of main physical parameters of Galactic open star clusters in huge multi-band photometric surveys; (2) study of optical-to-NIR galaxy colors using a large homogeneous dataset including spectroscopy and photometry from SDSS and UKIDSS; (3) study of faint low-mass X-ray binary population in modern observational archives; (4) search for optical counterparts of unidentified X-ray objects with large positional uncertainties in the Galactic Plane. All these projects make heavy use of the VO technologies and tools and would not be achievable without them. So refereed papers published i...

  2. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  3. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  4. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  5. Identification of the phd gene cluster responsible for phenylpropanoid utilization in Corynebacterium glutamicum.

    Science.gov (United States)

    Kallscheuer, Nicolai; Vogt, Michael; Kappelmann, Jannick; Krumbach, Karin; Noack, Stephan; Bott, Michael; Marienhagen, Jan

    2016-02-01

    Phenylpropanoids as abundant, lignin-derived compounds represent sustainable feedstocks for biotechnological production processes. We found that the biotechnologically important soil bacterium Corynebacterium glutamicum is able to grow on phenylpropanoids such as p-coumaric acid, ferulic acid, caffeic acid, and 3-(4-hydroxyphenyl)propionic acid as sole carbon and energy sources. Global gene expression analyses identified a gene cluster (cg0340-cg0341 and cg0344-cg0347), which showed increased transcription levels in response to phenylpropanoids. The gene cg0340 (designated phdT) encodes for a putative transporter protein, whereas cg0341 and cg0344-cg0347 (phdA-E) encode enzymes involved in the β-oxidation of phenylpropanoids. The phd gene cluster is transcriptionally controlled by a MarR-type repressor encoded by cg0343 (phdR). Cultivation experiments conducted with C. glutamicum strains carrying single-gene deletions showed that loss of phdA, phdB, phdC, or phdE abolished growth of C. glutamicum with all phenylpropanoid substrates tested. The deletion of phdD (encoding for putative acyl-CoA dehydrogenase) additionally abolished growth with the α,β-saturated phenylpropanoid 3-(4-hydroxyphenyl)propionic acid. However, the observed growth defect of all constructed single-gene deletion strains could be abolished through plasmid-borne expression of the respective genes. These results and the intracellular accumulation of pathway intermediates determined via LC-ESI-MS/MS in single-gene deletion mutants showed that the phd gene cluster encodes for a CoA-dependent, β-oxidative deacetylation pathway, which is essential for the utilization of phenylpropanoids in C. glutamicum. PMID:26610800

  6. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  7. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  8. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  9. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  10. Edmund Burke, the Atlantic American war and the ‘poor Jews at St. Eustatius’. Empire and the law of nations

    Directory of Open Access Journals (Sweden)

    Guido Abbattista

    2008-01-01

    Full Text Available This essay is devoted to a relatively minor episode in Edmund Burke’s parliamentary career and political speculation involving the rights of war and international law in the final years of the American War of Independence. The starting point for Burke’s consideration of these questions was the affair of St. Eustatius, that is to say Britain’s conquest in 1781 of the Dutch West-Indian island early in the “fourth Anglo-Dutch War” of 1780-1784. The harsh treatment of the Dutch colony’s cosmopolitan community by the commanding officers of the British Navy and Army provoked a series of reactions in Britain and the colonies. The essay starts by outlining the identity of St. Eustatius with its economic, demographic and social features, its peculiar role in the eighteenth-century West Indies and its emblematic meaning in the historical literature of the Enlightenment as a symbol of the virtues of commerce and of economic liberty. It goes on to analyse the facts of the military conquest in 1781 and the ensuing occupation realized by Admiral George Rodney and Major-General John Vaughan, particularly as this affected the “poor Jews at St. Eustatius” (as Burke himself qualified them in his second speech on 4 December 1781, with the subsequent reactions of the Dutch and especially the British Atlantic world. We then examine Edmund Burke’s reasons for taking up this affair, including the political and ideological motives and the sources of arguments he used in the two parliamentary speeches he made on the topic during 1781, relating this to Burke’s ideas on international relations and imperial government during the 1770s and 1780s. We end by pointing to cultural links between Burke’s positions and a wider political, commercial and civic culture emerging in the British Atlantic world which reflected some of the most typical European Enlightenment values and ideological commitments.

  11. Regulated expression of the nifM of Azotobacter vinelandii in response to molybdenum and vanadium supplements in Burk's nitrogen-free growth medium.

    Science.gov (United States)

    Lei, S; Pulakat, L; Gavini, N

    1999-10-14

    Azotobacter is a diazotrophic bacterium that harbors three genetically distinct nitrogenases referred to as nif, vnf, and anf systems. The nifM is an accessory gene located in the nif gene cluster and is transcriptionally regulated by the NifA. However, Azotobacter mutants that lack NifA are known to synthesize functional NifM and this accessory protein is known to be needed for the activity of nitrogenase-2 and nitrogenase-3. To determine how the transcription of nifM is regulated when Azotobacter is grown under conditions in which nitrogenase-2 or nitrogenase-3 is expressed, we generated an Azotobacter vinelandii strain that carries a nifM:lacZ-kanamycin resistance gene cassette in its chromosome. In this strain the nifM open reading frame was disrupted by the presence of a lacZ-kanamycin resistance gene cassette so that it could not produce active NifM. Moreover, the lacZ gene was placed under the transcriptional control elements of the nifM gene so that the lacZ expression could be used as a marker to determine the extent of expression of the nifM gene under different growth conditions. Our results show that this strain was unable to grow in Burk's nitrogen-free medium supplemented with either molybdenum or vanadium or lacking both metals suggesting that in the absence of functional NifM none of the nitrogenases were active. It was also found that the nifM expression was differentially regulated when the A. vinelandii cells were grown under conditions that activate nitrogenase-2 and nitrogenase-3, as determined by liquid beta-galactosidase activity measurements. These results suggest that the transcriptional activators, VnfA and AnfA, may regulate the nifM expression. PMID:10527862

  12. Academic and research misconduct in the PhD: issues for students and supervisors.

    Science.gov (United States)

    Mitchell, Theresa; Carroll, Jude

    2008-02-01

    There are many pressures upon PhD students not least the requirement to make an original or significant contribution to knowledge. Some students, confronted with complex research processes, might adopt practices that compromise standards that are unacceptable within a research community. These practices challenge the PhD student-supervisor relationship and have implication for the individual, the supervisory team, the institution, the awarding body and the wider research context. Discussion relating to misconduct within the PhD is of international importance if the aim is to encourage and facilitate rigorous research practice. Cases involving academic and research misconduct, especially those occurring at PhD level, are likely to become more frequent as numbers of PhD students increase and will demand appropriate, defensible responses from supervisors. Misconduct during PhD study can be difficult to resolve because of lack of clarity in definitions, supervisor naiveté and failure to acknowledge students' decision making limitations. Using scenarios from the first author's supervisory practice to illustrate issues of concern for students and supervisors during PhD supervision, the authors aim to illuminate the importance of engagement with regulatory bodies; problems of knowledge and understanding transfer; culturally specific issues and meanings of academic theft. PMID:17590482

  13. The cultivar-specific expression patterns of MdACS3 gene and apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks bef...

  14. The role of cultivar-specific expression patterns of MdACS3 gene on apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks befo...

  15. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  16. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Gang G.; Song, Jikui; Wang, Zhanxin; Dormann, Holger L.; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J.; Allis, C. David; (MSKCC); (Scripps); (Rockefeller)

    2009-07-21

    Histone H3 lysine4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  17. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  18. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  19. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  20. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    Science.gov (United States)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  1. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...... sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided...

  2. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  3. Strategy formulation for the Phd Health Market (Pty) Ltd franchise group / Henk Heath

    OpenAIRE

    Heath, Henk

    2007-01-01

    Phd Health Market (Pty) Ltd was born from the vision of Anton Dupper and Advocate Jan Grobler, to turn a health store in Welkom, South Africa, into a national health franchise in the health & fitness industry. Phd Health Market has a vision to radically change society as a whole by changing nutritional eating and instilling a healthy lifestyle as a whole, which could be easily adapted by all. Phd Health Market is a small developing franchise group, requiring a much needed strategic plan in or...

  4. Creating entrepreneurial networks : academic entrepreneurship, mobility and collaboration during PhD education

    OpenAIRE

    Bienkowska, Dzamila; Klofsten, Magnus

    2012-01-01

    Network-building activities of PhD students are an important area of study in furthering our understanding of academic entrepreneurship. This paper focuses on PhD students’ participation in network-building activities defined as mobility and collaboration, as well as own interest in and perceived grade of support for commercialisation from various levels of the university hierarchy. The results of a large-scale survey (of 1,126 PhD students at Linköping University, Sweden, 41% response rate) ...

  5. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  6. MD&A – Counterpart to or Distraction from Financial Reporting

    OpenAIRE

    Kevin Girdharry; Elena Simonova; Rock Lefebvre

    2011-01-01

    MD&A content has been an ongoing topic of recent debate with the views divided on the impact that regulated content has on the quality of the MD&A. Complexity has amplified as a result of emerging issues of particular importance to investors such as transition to IFRS, the environment and executive compensation. This paper examines companies’ compliance with requirements of the Canadian Securities Administrators for MD&A disclosures, and aims to advance understand on whether following CSA req...

  7. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  8. Precancer: The Beginning and the End of Cancer. Edited by Jules J. Berman, MD, PhD (E-Mail: jjberman1@comcast.net with G. William Moore, MD, PhD. Jones & Bartlett Publishers: Sudbury, MA, USA, 2009; 186 pp; 42.95$; ISBN: 9780763777845

    Directory of Open Access Journals (Sweden)

    Kara L. Kuntz-Melcavage

    2009-12-01

    Full Text Available This concisely written book makes a powerful argument that the focus of research in the cancer field should be shifted from full-stage cancer to the more promising area of precancer. The entire book encompasses less than 200 pages, including an extensive glossary aimed at clarifying terminology with which a person lacking a research background may be unfamiliar. Because explanations of scientific terminology are located in the glossary, Berman and Moore have prevented the book from being too elementary for an advanced scientist. The logical organization of the chapters results in this becoming quite an easy book to read. [...

  9. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  10. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  11. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    OpenAIRE

    Tesh, Vernon L.

    2016-01-01

    With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  12. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    Directory of Open Access Journals (Sweden)

    Vernon L. Tesh

    2016-02-01

    Full Text Available With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  13. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  14. Trends in landscape research and landscape planning : implications for PhD students

    OpenAIRE

    Tress, G.; Tress, B; Fry, G; Antrop, M

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  15. Jamika Burge one of 50 worldwide to receive IBM Ph.D. fellowship

    OpenAIRE

    Crumbley, Liz

    2005-01-01

    Jamika Burge of Rome, Ga., a doctoral student in the Virginia Tech College of Engineering's Department of Computer Science, has been selected to receive an IBM Ph.D. Fellowship for the 2005-2006 academic year.

  16. PhD Wang Xingchu,A Successful Leader of A High-tech Company Reform

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ PhD Wang Xingchu was born in 1962. He is the Board Chairman of Shanghai Biotechnology Industrial Garden Coalition Development Co., Ltd. and the General Manager of Shanghai Hua Xin High-Biotechnology Co., Ltd.

  17. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  18. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are s

  19. Articulating Expectations for PhD Candidature upon Commencement: Ensuring Supervisor/Student "Best Fit"

    Science.gov (United States)

    Moxham, Lorna; Dwyer, Trudy; Reid-Searl, Kerry

    2013-01-01

    The journey towards completion of a PhD is a bumpy one for many. One of the major factors that influence successful and on-time thesis completion is the relationship that the PhD candidate has with her or his supervisor. This paper presents results from research undertaken using a 12-item survey to collect data from a purposive sample: PhD…

  20. PhD Seminar within the framework of Water Doctoral Network of Engineering and Management

    OpenAIRE

    Kluska, Andreas; Stefan, Catalin

    2013-01-01

    The Water Doctoral Network of Engineering and Management is a bilateral German – Vietnamese academic network with the aim to provide a platform for the development of joint research activities in water sector. Within the framework of the project, the network members organised a series of workshops and seminars targeted especially at PhD students from universities conducting research programs in water-related issues from both countries. The present paper summarises the outcomes of the last PhD...

  1. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twent...... industrial enterprises into account. Projects are included covering mathematical modelling, simulation, analysis, experiments, implementation and prototyping....

  2. Report on the International PhD School ''Science and Technology with the E-ELT''

    Science.gov (United States)

    Bono, G.; Hook, I.; Ramsay, S.

    2015-12-01

    This international PhD school in the F. Lucchin cycle was the first to bring together Masters and PhD students with an interest in all aspects of the science and technology of the European Extremely Large Telescope (E-ELT). It was fitting that this school was held within a year of the project formally entering the construction phase. An overview of the topics covered during the school is presented.

  3. The evaluation of reproductive health PhD program in Iran: The input indicators analysis

    OpenAIRE

    AbdiShahshahani, Mahshid; Ehsanpour, Soheila; Yamani, Nikoo; Kohan, Shahnaz

    2014-01-01

    Background: Appropriate quality achievement of a PhD program requires frequent assessment and discovering the shortcomings in the program. Inputs, which are important elements of the curriculum, are frequently missed in evaluations. The purpose of this study was to evaluate the input indicators of reproductive health PhD program in Iran based on the Context, Input, Process, and Product (CIPP) evaluation model. Materials and Methods: This is a descriptive and evaluative study based on the CIPP...

  4. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  5. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  6. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  7. MS PHD'S: Effective Strategies for the Retention and Advancement of URM Students in ESS

    Science.gov (United States)

    Escalera, J.; Burgess, A. K.; Pace, L.; Scott, O.; Strickland, J.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.

    2012-12-01

    The Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) Professional Development Program in Earth system science (ESS) is a model initiative for improving the retention of underrepresented minority (URM) students in STEM fields. Entering its ninth cohort, MS PHD'S remains committed to helping URM undergraduate and graduate students achieve outstanding careers in ESS. MS PHD'S facilitates URM student achievement through a three-phase program designed to increase student exposure to the ESS community. By engaging in a series of professional development and skill building exercises, peer-to-peer community building activities, participation in scientific society conferences and workshops, mentoring by URM and other scientists, and a virtual community, URM students gain the confidence and support necessary to achieve their academic goals and enter the ESS workforce. Since its inception, MS PHD'S continues to support 189 participants. Of these 189 participants, 35 have advanced from undergraduate and graduate academic pathways to completion of their PhD and another 60 are currently enrolled in doctoral programs. MS PHD'S maintains close ties with program alumni to further support retention, inclusivity, and broadening participation of URM students and graduates in STEM activities. Its model is built on reengaging alumni to become mentors and leaders for each new cohort as well as facilitating valuable opportunities for alumni to advance in their ESS related academic and professional career pathways.

  8. PHD2在宫颈病变中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    朱诚程; 周家德; 倪观太; 孙恒亮

    2014-01-01

    目的:研究不同宫颈组织中脯氨酸羟化酶2( PHD2)的表达情况,初步探讨PHD2在宫颈病变中的作用和意义。方法:选取正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌标本各20例,应用逆转录多聚酶链反应( RT-PCR)、免疫组化法( SP法)检测PHD2 mR-NA和蛋白水平的相对表达情况。结果:正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌组织中,PHD2蛋白和mRNA表达水平依次上调,两两比较差异均有统计学意义(P<0.01)。结论:PHD2可能参与宫颈病变的发生发展,作为肿瘤标记物用于早期诊断和预后判断。下调PHD2的高表达,可能成为治疗宫颈癌的新靶点。

  9. 78 FR 59060 - Gabriel Sanchez, M.D.; Decision and Order

    Science.gov (United States)

    2013-09-25

    ... any compression of the nerves, or the spinal column, or the nerve root,'' and that it was ``difficult... sufficiently reliable to be accepted and relied upon in this .'' See Cynthia M. Cadet, M.D., 76 FR 19450, 19458... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003)....

  10. Measurement of Delta-md Using a Probability Based Same-Side Tagger at CDF

    OpenAIRE

    Bauer, G

    2000-01-01

    A measurement of Delta m_d is performed using inclusive lepton+vertex events at CDF. A probability based Same-Side Tagger was developed to tag the initial b-flavor of the B^0_d, which suppresses tagging on B-decay products. We find Delta m_d = 0.42 +/- 0.09 +/- 0.03 ps^-1.

  11. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  12. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  13. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens

    Science.gov (United States)

    Marek’s disease (MD) is a lymphoproliferative disease induced by Marek’s disease virus (MDV). To augment vaccination, the host genetic resistance is of importance in MD control. While researchers have been largely focused on exploring the genetic differences between resistant and susceptible chicken...

  14. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  15. Transport and characterization of ambient biological aerosol near Laurel, MD

    Directory of Open Access Journals (Sweden)

    J. L. Santarpia

    2010-09-01

    Full Text Available Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

  16. The MD simulation of thermal properties of plutonium dioxide

    International Nuclear Information System (INIS)

    The thermodynamic properties of PuO2 have been investigated between 300 and 3000 K by molecular dynamics (MD) simulation with empirical interaction potential. The properties include melting point, lattice parameter variation, enthalpy and heat capacity. The melting point of two-phase simulation (TPS) is in agreement with the experimental value, and it gives a much lower value than one-phase simulation (OPS). The lattice parameter and heat capacity at high temperatures are expressed as a(T)=5.38178+4.38×10-5T+6.5525×10-9T2+0.9362×10-12T3 and CP(KJ⋅mol-1⋅K-1)=18648.8e474.5/T/(T2(e474.5/T-1)2)+9.337×10-6T, respectively. True linear thermal expansion coefficient (TLTEC) α is about 8.89×10-6 K-1 at 300 K. Our simulation results are in good agreement with experimental and other theoretical data.

  17. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  18. From Doctoral Student To Faculty Member: PhD. Project Alumni’s Evaluation Of Their Preparedness

    Directory of Open Access Journals (Sweden)

    Bill N. Schwartz

    2012-03-01

    Full Text Available In response to the important issues regarding diversity in business schools and corporate America, the KPMG Foundation established the PhD Project. The PhD Project helps business professionals and recent college graduates earn doctoral degrees in business disciplines and join business school faculty. While the PhD Project has helped increase the number of minority faculty members in business schools, it may be helpful to gather insights from the recent PhD alumni who have received support from the PhD Project. Our study examines attitudes about preparedness of PhD Project alums for their first faculty position after completing their PhD program. Results show that PhD Project alumni and majority PhD alumni (alumni not associated with the PhD Project felt they were prepared for their first faculty position, but they were not significantly different in their evaluation in most respects. However, to our surprise, majority PhD alumni felt they were better prepared for research than PhD Project alumni. This difference was significant and further analyses showed that younger faculty and those in the ethnic majority were better prepared for research. Both groups considered themselves well prepared for research and teaching. Neither group was as optimistic about being prepared for service responsibilities and the academic climate or politics of an academic career. Our findings show that the PhD Project is necessary to help ensure that minority faculty members are adequately prepared for research and their academic careers.

  19. Professional Socialization for the Ph.D.: An Exploration of Career and Professional Development Preparedness and Readiness for Ph.D. Candidates

    Science.gov (United States)

    Helm, Matt; Campa, Henry, III; Moretto, Kristin

    2012-01-01

    This study sought to uncover the career readiness and professional development needs of Ph.D. students at a large, Midwestern research university. Findings indicate that career goals of graduate students change over time, skill preparation for academic and non-academic careers continues to be inadequate for many students and professional…

  20. Política, religião, revolução e soberania em Reflexões sobre a revolução em França do conservador E. Burke

    Directory of Open Access Journals (Sweden)

    Raquel Kritsch

    2011-08-01

    Full Text Available

    O objetivo deste artigo é introduzir ao leitor o pensamento político de Edmund Burke, um dos nomes mais influentes do pensamento político conservador. A partir de uma breve contextualização da crítica burkeana ao racionalismo iluminista, o artigo procura mostrar como o autor organiza conceitos centrais de sua teoria política, como poder, legitimidade, conservação, correção, preconceito, prescrição, num discurso articulado e coerente, com o objetivo de sustentar que na Inglaterra política e religião constituem, juntas, não só a base não só da prosperidade do povo mas também o fundamento do Estado. Em seguida, aborda-se a crítica de Burke à Revolução Francesa, à “psicologia dos revolucionários” e, de maneira mais detida, aos direitos do homem, discutindo alguns de seus argumentos contra as abstrações distanciadas das práticas concretas dos coletivos humanos e a transformação da metafísica moderna num programa político.

  1. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  2. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  3. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  4. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  5. On the Importance of PhD Institute in Establishing a Long-Term Research Career in Astronomy

    OpenAIRE

    Gibson, Brad K.; Buxton, Michelle; Vassiliadis, Emanuel; Sevenster, Maartje N.; Jones, D. Heath; Thornberry, Rebecca K.

    1999-01-01

    We have examined the success rates of 19 American, Canadian, Australian, and Dutch graduate programs in producing astronomers. A 20-year baseline was considered (1975-1994), incorporating 897 PhD recipients. The major conclusion from our study is that the fraction of PhD graduates still involved in astronomical research is surprisingly insensitive to the institutional source of one's PhD. With few exception, 55-75% of graduates, regardless of PhD source, remain active in the astronomical rese...

  6. Was it worth it? An empirical analysis of over-education among Ph.D. recipients in Italy

    OpenAIRE

    Giuseppe Lucio Gaeta

    2013-01-01

    This paper aims to provide an empirical examination of factors associated with overeducation among Ph.D. graduates in Italy. Our investigation is based on recently released data collected by the Italian National Institute of Statistics by means of interviews with a large sample of Ph.D. recipients, carried out a few years after they obtained their Ph.D. degree. We measured the mismatch between their current job and previous Ph.D. studies using two direct subjective evaluations of over-educati...

  7. Preparing Postbaccalaureates for Entry and Success in Biomedical PhD Programs.

    Science.gov (United States)

    Hall, Joshua D; Harrell, Jessica R; Cohen, Kimberley W; Miller, Virginia L; Phelps, Patricia V; Cook, Jeanette G

    2016-01-01

    Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school. Scholar critical analysis skills, lab technique knowledge, and Graduate Record Examination scores all improved significantly during the program. Scholars reported significant confidence growth in 21 of 24 categories related to success in research careers. In 5 yr, 91% (41/45) of scholars transitioned directly into PhD programs. Importantly, 40% (18/45) of participating postbaccalaureate scholars had previously been declined acceptance into graduate school; however, 17/18 of these scholars directly entered competitive PhD programs following our training program. Alumni reported they were "extremely well" prepared for graduate school, and 95% (39/41) are currently making progress to graduation with a PhD. In conclusion, we report a model for postbaccalaureate training that could be replicated to increase participation and success among UR scholars in the biomedical sciences. PMID:27496358

  8. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  9. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  10. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  11. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  12. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  13. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  14. Publication rate and PhD enrolment following a medical pre-graduate research programme

    DEFF Research Database (Denmark)

    Skovgaard, Marlene; Okkels, Niels; Christensen, Mette Krogh;

    2015-01-01

    INTRODUCTION: In the 1990s, the publication and PhD recruitment rates following the Danish pre-graduate research programme (PGRP) in medicine were 54% and 33%, respectively. Updated estimates are unknown. METHODS: All medical students enrolled in the PGRP at the Faculty of Medicine, Aarhus...... PGRP compared to female medical students (28% versus 19%; p < 0.01). Within three and a half years from PGRP initiation, 13% of the research students had enrolled in a PhD programme at Health, and 52% had published ≥ 1 paper with ≥ 1 supervisor. The research student was the first author on 43% of the...... University (Health), Denmark, during 2003-2012 were included (n = 687). The PGRP files were merged with PhD students' files at Health. A systematic literature search was completed for research students who had enrolled during the 2006-2009 period (n = 227). The factors investigated were student age, sex...

  15. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  16. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  17. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations.

    Science.gov (United States)

    Vallejo, Celeste R; Lee, Jo Ann; Keesling, James E; Geden, Christopher J; Lietze, Verena-Ulrike; Boucias, Drion G

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  18. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... girlfriend admitting to a soft- drink adulteration that never occurred.'' Id. at 32. Moreover, even after...

  19. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-08-24

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  20. The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

    Institute of Scientific and Technical Information of China (English)

    Nan Chen; Oliver Rinner; Dominika Czernik; Katarzyna J Nytko; Dan Zheng; Daniel P Stiehl; Nicola Zamboni; Matthias Gstaiger; Christian Frei

    2011-01-01

    @@ Dear Editor, Oxygen levels are critical for cellular physiology.Under low oxygen (hypoxia),cells increase glycolysis while limiting mitochondrial oxidative metabolism.Such adaptation is largely mediated by the transcription factors HIF,which accumulate under hypoxia [1,2].Prolyl hydroxylase domain proteins (PHD) function as cellular oxygen sensors and target HIF for subsequent degradation under normoxia [2].The PHD/HIF pathway is conserved in Drosophila,where a single prolyl hydroxylase,Fatiga,has been characterized.We have previously reported that Fatiga regulates cellular growth rates in a HIF-independent manner,yet mechanisms remained elusive [3].

  1. Top tips for PhD thesis examination: nurse clinicians, researchers and novices.

    Science.gov (United States)

    Cleary, Michelle; Horsfall, Jan; Hunt, Glenn E

    2012-01-01

    Interestingly, there are very few guidelines in the literature to assist novice nurse PhD examiners. In this paper, we aim to provide information to nurses, researchers or early career academics who have little experience in assessing a university thesis. The article provides background information about recent changes in the university sector; overviews some research on experienced examiners views; presents factors that differentiate between high and low quality PhD theses; and outlines some pointers that may be useful when marking at the doctoral level. PMID:21903305

  2. The Science Impact of Astronomy PhD Granting Departments in the United States

    OpenAIRE

    Kinney, Anne L.

    2008-01-01

    The scientific impact of the research of 36 astronomy PhD granting departments is measured and ranked here. Because of the complex nature of Universities, this study looks at the Universities in two ways; first analyzing the impact of the published work over a 10 year period of the Department which grants the PhD and; second, looking at the impact of the published work as a whole including Laboratories, Centers, and Facilities. The Universities considered in the study are drawn from the 1992 ...

  3. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  4. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  5. Productive replication of Malacosoma neustria nucleopolyhedrovirus (ManeNPV) in Md203 cell line

    OpenAIRE

    DEMİR, İsmail; GÜREL, Nurten; NALÇACIOĞLU, Remziye; İNCE, İkbal A.; DEMİRBAĞ, Zihni

    2009-01-01

    A plaque-purified genotypic variant, derived from a field isolate of the Malacosoma neustria nucleopolyhedrovirus (ManeNPV) from Turkey was characterized based on in vitro replication properties in a cell line, Md203 derived from Malacosoma disstria. The life cycle of ManeNPV was studied based on the cytopathic effects (CPEs), polyhedral inclusion body (PIB) formation, budded virus (BV) production, viral DNA replication and polyhedrin protein expression in ManeNPV-infected Md203 cells. Infec...

  6. MD-CTS: An integrated terminology reference of clinical and translational medicine

    OpenAIRE

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is access...

  7. Parallel cascade selection molecular dynamics (PaCS-MD) to generate conformational transition pathway

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-01

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  8. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Directory of Open Access Journals (Sweden)

    Gardie B

    2014-07-01

    of EPO transcription. The α subunits of the hypoxia-inducible transcription factor are hydroxylated by three prolyl hydroxylase domain (PHD enzymes, which belong to the iron and 2-oxoglutarate-dependent oxygenase superfamily. Sequence analysis of the genes encoding the PHDs in patients with erythrocytosis has revealed heterozygous germline mutations only occurring in Egl nine homolog 1 (EGLN1, also known as PHD2, the gene that encodes PHD2. To date, 24 different EGLN1 mutations comprising missense, frameshift, and nonsense mutations have been described. The phenotypes associated with the patients carrying these mutations are fairly homogeneous and typically limited to erythrocytosis with normal to elevated EPO. However, exceptions exist; for example, there is one case with development of concurrent paraganglioma (PHD2-H374R. Analysis of the erythrocytosis-associated PHD2 missense mutations has shown heterogeneous results. Structural studies reveal that mutations can affect different domains of PHD2. Some are close to the hypoxia-inducible transcription factor α/2-oxoglutarate or the iron binding sites for PHD2. In silico studies demonstrate that the mutations do not always affect fully conserved residues. In vitro and in cellulo studies showed varying effects of the mutations, ranging from mild effects to severe loss of function. The exact mechanism of a potential tumor-suppressor role for PHD2 still needs to be elucidated. A knockin mouse model expressing the first reported PHD2-P317R mutation recapitulates the phenotype observed in humans (erythrocytosis with inappropriately normal serum EPO levels and demonstrates that haploinsufficiency and partial deregulation of PHD2 is sufficient to cause erythrocytosis. Keywords: PHD2, EGLN1, HIF, hypoxia, erythropoietin, erythrocytosis

  9. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A;

    2015-01-01

    , which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co...

  10. Models of text mining to measure improvements to doctoral courses suggested by “STELLA” phd survey respondents

    Directory of Open Access Journals (Sweden)

    Pasquale Pavone

    2014-10-01

    Full Text Available We present Text Mining models to thematically categorise and measure the suggestions of  PhD holders on improving PhD programmes in the STELLA survey (Statistiche in TEma di Laureati e LAvoro. The coded responses questionnaire, designed to evaluate the employment opportunities of students and assess their learning experience, included open-ended questions on how to improve PhD programmes. The Corpus analysed was taken from the data of Italian PhD holders between 2005 and 2009 in eight universities (Bergamo, Brescia, Milano Statale, Milano Bicocca, Pisa, Scuola Superiore Sant’Anna, Palermo and Pavia. The usual methodological approach to text analysis allowed us to categorize open-ended proposals of PhD courses improvements in 8 Italian Universities.

  11. Completing a PhD by Publication: A Review of Australian Policy and Implications for Practice

    Science.gov (United States)

    Jackson, Denise

    2013-01-01

    There is increasing impetus for higher-degree-by-research students to publish during candidature. Research performance, including higher degree completions and publication output, commonly determines university funding, and doctorates with publishing experience are better positioned for a career in softening academic labour markets. The PhD by…

  12. Learning to Become Teacher Educators: Testimonies of Three PHD Students in China

    Science.gov (United States)

    Yuan, Rui

    2015-01-01

    While there has been an increasing number of graduate students who enter teacher education after obtaining a higher research degree (e.g., PhD or EdD), scant attention has been paid to their professional learning as prospective teacher educators in higher education. To fill this gap, this study, informed by the social theory of learning,…

  13. Training of young researchers and PhD supervisors for the future

    DEFF Research Database (Denmark)

    Kolmos, Anette

    which contributes to break down the usual ways of thinking and to incorporate both intercultural and interdisciplinary principles, and a valued orientation towards trade and industry. The PhD supervisors should also be trained so that light is thrown on the aims, methods and contents of the supervision...

  14. The Impact of Institutional Student Support on Graduation Rates in US Ph.D. Programmes

    Science.gov (United States)

    Bolli, Thomas; Agasisti, Tommaso; Johnes, Geraint

    2015-01-01

    Using National Research Council data, we investigate the determinants of graduation rates in US Ph.D. programmes. We emphasise the impact that support and facilities offered to doctoral students have on completion rates. Significant, strong and positive effects are found for the provision of on-site graduate conferences and dedicated workspace,…

  15. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  16. Career-Self Management and Entrepreneurship: An Experience with PhD Students

    Science.gov (United States)

    Pinto, Joana Carneiro; do Ceu Taveira, Maria; Sa, Elisabete

    2012-01-01

    Introduction: This study presents an experience developed with PhD students aimed to analyze the extent to which career self-management should be approached along with entrepreneurship issues to promote students' career development. Method: An intervention group who attended a Career Self-Management Seminar (EG1), a comparison group who attended…

  17. The Focus and Substance of Formative Comment Provided by PhD Examiners

    Science.gov (United States)

    Holbrook, Allyson; Bourke, Sid; Fairbairn, Hedy; Lovat, Terence

    2014-01-01

    In practice and process PhD examination is distinctive, reflecting the high expectations of students whose learning has been directed to their becoming researchers. This article builds on previous research on the examination of Australian theses that revealed that examiners in Science (n?=?542) and Education (n?=?241) provide a substantial…

  18. PhD versus DSW: A Critique of Trends in Social Work Doctoral Education

    Science.gov (United States)

    Howard, Tyriesa

    2016-01-01

    Social work educators are in a phase of reintroducing the doctor of social work (DSW) degree and refining distinctions between PhD and DSW doctoral programs. This article examines how the two options have been prey to a noticeable "seesaw of precedence", resulting in a debatable history of social work's approach to doctoral education…

  19. Imaginaries of "Europe" in the Governmentality of PhD Education

    Science.gov (United States)

    Bergviken Rensfeldt, Annika

    2014-01-01

    This article examines the recent European governing of PhD education by describing and destabilizing how Europe, as a social construct, is inscribed in the governing in multiple ways. Conceptually, it aligns with post-Foucauldian research interests in imaginaries of societies, subjectivities, and politics of knowledge. Based on European policies…

  20. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  1. The Impact of Publishing during PhD Studies on Career Research Publication, Visibility, and Collaborations

    Science.gov (United States)

    Horta, Hugo; Santos, João M.

    2016-01-01

    This study analyzes the impact that publishing during the period of PhD study has on researchers' future knowledge production, impact, and co-authorship. The analysis is based on a representative sample of PhDs from all fields of science working in Portugal. For each researcher in the dataset, we compiled a lifetime publication record and…

  2. Ability, academic climate, and going abroad for work or pursuing a PhD

    NARCIS (Netherlands)

    Bertrand-Cloodt, D.A.M.; Cörvers, F.; Heijke, J.A.M.

    2014-01-01

    We investigate whether a creaming off of highly able students from Dutch universities is taking place. Therefore, we examine the relation between ability and the destination of recent graduates of Dutch universities. Students can choose to continue their academic career by investing in a PhD degree

  3. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  4. International Students' Motivation to Pursue and Complete a Ph.D. in the U.S.

    Science.gov (United States)

    Zhou, Ji

    2015-01-01

    This study explores what motivates 19 international students to pursue a Ph.D. at a public research university in the U.S. and, more importantly, what motivates them to persist despite unsatisfying socialization. Based on value-expectancy achievement motivation theory, four motivations emerged: intrinsic interest in research, intrinsic interest in…

  5. Re-Envisioning the Arts PhD: Intellectual Entrepreneurship and the Intellectual Arts Leader

    Science.gov (United States)

    Cherwitz, Richard A.; Beckman, Gary D.

    2006-01-01

    The authors of this article contend that most doctoral students in the arts do not fully appreciate the meaning of their PhD, and that the current system of graduate education perpetuates this phenomenon, with each generation of professors passing down their understanding of the doctorate to succeeding generations. The authors argue that what is…

  6. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts presented illustrate…

  7. A National Content Analysis of PhD Program Objectives, Structures, and Curricula: Do Programs Address the Full Range of Social Work's Needs?

    Science.gov (United States)

    Drisko, James; Hunnicutt, Christie; Berenson, Laura

    2015-01-01

    The Group for the Advancement of Doctoral Education (GADE) promotes excellence in PhD education in Social Work. GADE's 2013 Quality Guidelines for PhD Programs heavily emphasize preparation for research. Little is known, however, about the details of the contemporary social work PhD program structure and curriculum. Several prior surveys have…

  8. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  9. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  10. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  11. The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.

    Science.gov (United States)

    Rack, Johannes G M; Lutter, Timo; Kjæreng Bjerga, Gro Elin; Guder, Corina; Ehrhardt, Christine; Värv, Signe; Ziegler, Mathias; Aasland, Rein

    2014-12-12

    In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional relationship between the acetyltransferase domain and the adjacent bromodomain/PHD finger (bromo/PHD) region of the transcriptional coactivator p300. We found that the bromo/PHD region of p300 can bind to the acetylated catalytic domain in vitro and augment the catalytic activity of the enzyme. Deletion of the PHD finger, but not the bromodomain, impaired the ability of the enzyme to acetylate histones in vivo, whilst it enhanced p300 self-acetylation. A point mutation in the p300 PHD finger that is related to the Rubinstein-Taybi syndrome resulted in increased self-acetylation but retained the ability to acetylate histones. Hence, the PHD finger appears to negatively regulate self-acetylation. Furthermore, our data suggest that the PHD finger has a role in the recruitment of p300 to chromatin. PMID:25158095

  12. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  13. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  14. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  15. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  16. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  17. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  18. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  19. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  20. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  1. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  2. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  3. The use of a Virtual Community to Complement the MS PHD'S Professional Development Program

    Science.gov (United States)

    Nieves, I. U.; Brown, D. C.; Bailey, K.; Easley, R.; Johnson, A.; Ithier, W.; Powell, J. M.; Whitney, V. W.; Pyrtle, A. J.

    2005-12-01

    The aim of the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Sciencer Professional Development Program (MS PHD'S PDP) is to provide professional and mentoring experiences that facilitate the advancement of minorities committed to achieving outstanding Earth system science and engineering careers. The MS PHD'S PDP is structured in three phases that are connected by engagement in virtual community building activities, allowing for continuous peer to peer and mentor to mentee interactions. These activities occur through the use of the MSPHD'S website forum and web cam dialogues. In addition, the virtual community provides the personal and professional support necessary to ensure the success of the students. Examples of interactions within the MSPHD'S PDP virtual community will be presented.

  4. The training, careers, and work of Ph.D. physical scientists: Not simply academic

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-11-01

    We present an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Use of specialized training varies widely, with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other important measures, there are relatively few differences between "academics" and "nonacademics." Important job skills for all employment sectors include writing, oral presentation, management, data analysis, designing projects, critical thinking, and working in an interdisciplinary context. Rankings given by respondents of graduate training in some of these skill areas were significantly lower than the importance of these skills in the workplace. We also found that the rated quality of graduate training varies relatively little by department or advisor. Finally, although nonacademic aspirations among graduate students are fairly common, these do not appear to be well supported while in graduate school.

  5. Publication ethics from the perspective of PhD students of health sciences: a limited experience.

    Science.gov (United States)

    Arda, Berna

    2012-06-01

    Publication ethics, an important subtopic of science ethics, deals with determination of the misconducts of science in performing research or in the dissemination of ideas, data and products. Science, the main features of which are secure, reliable and ethically obtained data, plays a major role in shaping the society. As long as science maintains its quality by being based on reliable and ethically obtained data, it will be possible to maintain its role in shaping the society. This article is devoted to the presentation of opinions of PhD candidate students in health sciences in Ankara concerning publication ethics. The data obtained from 143 PhD students from the fields of medicine, dentistry, pharmacy and veterinary reveal limited but unique experiences. It also shows that plagiarism is one of the worst issues in the publication ethics from the perspective of these young academics. PMID:21318323

  6. SMC-PHD based multi-target track-before-detect with nonstandard point observations model

    Institute of Scientific and Technical Information of China (English)

    占荣辉; 高彦钊; 胡杰民; 张军

    2015-01-01

    Detection and tracking of multi-target with unknown and varying number is a challenging issue, especially under the condition of low signal-to-noise ratio (SNR). A modified multi-target track-before-detect (TBD) method was proposed to tackle this issue using a nonstandard point observation model. The method was developed from sequential Monte Carlo (SMC)-based probability hypothesis density (PHD) filter, and it was implemented by modifying the original calculation in update weights of the particles and by adopting an adaptive particle sampling strategy. To efficiently execute the SMC-PHD based TBD method, a fast implementation approach was also presented by partitioning the particles into multiple subsets according to their position coordinates in 2D resolution cells of the sensor. Simulation results show the effectiveness of the proposed method for time-varying multi-target tracking using raw observation data.

  7. Strategies for a successful PhD program: words of wisdom from the WJNR Editorial Board.

    Science.gov (United States)

    Conn, Vicki S; Zerwic, Julie; Rawl, Susan; Wyman, Jean F; Larson, Janet L; Anderson, Cindy M; Fahrenwald, Nancy L; Benefield, Lazelle E; Cohen, Marlene Z; Smith, Carol E; Topp, Robert; Markis, Natalie E

    2014-01-01

    Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership. PMID:23797100

  8. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  9. ChemSession'07 - 4th Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    4th Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  10. ChemSession'11 - 8. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations: 4 lectures, 1 communication and 149 posters presented during ChemSession'11 - 8th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 13.05.2011). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  11. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  12. Governance configurations and academic outcomes: The example of Ph.D. education

    OpenAIRE

    Schneider, Peter; Sadowski, Dieter

    2010-01-01

    In many European countries efforts are undertaken to improve doctoral education. In the context of new public governance in the Higher Education sector, less state, more competition, less academic self-governance, more internal hierarchy and more influence by external stakeholders under the common roof of New Public Management (NPM) are considered most promising for successful PhD education. Therefore according to a steering model of American research universities many initiatives are underta...

  13. "Essays on International Business Cycles", PhD thesis, Economics Department, University of Chicago, 1991.

    OpenAIRE

    Kollmann, Robert

    1991-01-01

    PhD dissertation, 1991, Economics Department, University of Chicago. (Thesis committee: Michael Woodford, advisor; José Scheinkman; John Huizinga.) Models of the international economy which assume complete asset markets predict that consumption co-moves closely in different countries as this structure of asset markets allows agents in different countries to 'pool' the country-specific risks which they face (see Scheinkman (1984), Leme (1984)). Examples in this class of models include the...

  14. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    OpenAIRE

    Camelia Popa

    2013-01-01

    As a whole, this PhD thesis follows three research lines, namely: (1) the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2) the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3) the line of an awareness of the need to prevent and fight against the effects...

  15. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  16. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    3rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  17. ChemSession'10: 7. Warsaw Seminar of the PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations 4 lectures and 151 posters presented during ChemSession'10 - 7th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 14.05.2010). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  18. CERGE-EI: The American-style PhD program in economics for transition economies

    Czech Academy of Sciences Publication Activity Database

    Švejnar, Jan

    Washington, DC : International Bank for Reconstruction and Development/The World Bank, 2007 - (Bourguignon, F.; Elkana, Y.; Pleskovic, B.), s. 301-316 ISBN 978-0-8213-6595-3. [Scaling Up Capacity Building in Economics Education and Research: Lessons Learned and Future Directions. Budapest (HU), 14.06.2005-15.06.2005] Institutional research plan: CEZ:AV0Z70850503 Keywords : economics education * economics research * CERGE-EI * PhD program Subject RIV: AH - Economics

  19. Pathways to the PhD in Nursing: An Analysis of Similarities and Differences.

    Science.gov (United States)

    Nehls, Nadine; Barber, Gale; Rice, Elizabeth

    2016-01-01

    New educational pathways are needed to increase the number of doctor of philosophy (PhD)-prepared nurses. To address this need, an early-entry PhD option designed to engage students in PhD coursework and research during the undergraduate nursing major was developed at the University of Wisconsin-Madison. An evaluation comparing the early-entry option with two more conventional entry points was conducted. Three groups (N = 84) comprised the sample: (a) early-entry students admitted as undergraduates or immediately upon graduation (N = 29), (b) mid-entry students with baccalaureate degrees and at least 1 year of work experience (N = 27), and (c) delayed-entry students with master's degrees and 1 or more years of work experience (N = 28). Qualitative and quantitative data were collected from the 3 groups of students who were admitted from 2002 to 2011. The sources of data were transcriptions of individual interviews and reviews of existing data. Seventy-seven percent of the sample participated in the individual interviews. The database review included all students who matriculated into the PhD program. Common themes among the 3 groups included a need for educational funding, the importance of a faculty mentor, and concern about preparation for the teaching role and the academic work environment. The groups were also comparable in terms of research productivity during doctoral study and postgraduation employment. Differences were found on measures of diversity, program progression, and perceptions of clinical competence. The findings provide needed data for the development and expansion of educational pathways to the PhD in nursing. PMID:27216124

  20. Education Blues : A Study of the Emotional Roller Coaster Rideof Ph.D. Education

    OpenAIRE

    Berggren, Uffe

    2012-01-01

    The study makes use of theories of emotions to describe and analyze interviewsconducted with eight students who had recently taken part in, or were at the moment,taking part in a doctoral education at the Faculties of Humanities or Social Science atStockholm University. This study is thus a qualitative study focusing on the followingresearch questions: Firstly, how does the Ph.D education influence the studentemotionally. Secondly: do the participants in the doctoral education experienceemoti...

  1. A call for performance-based data in the study of STEM Ph.D. education

    OpenAIRE

    David F. Feldon; Maher, Michelle A.; Timmerman, Briana E.

    2010-01-01

    Understanding the scholarly development of Ph.D. students in science, technology, engineering, and mathematics (STEM) is vital to the preparation of the scientific workforce. During doctoral study, students learn to be professional scientists and acquire the competencies to succeed in those roles. However, this complex process is not well studied. Research to date suffers from overreliance on a narrow range of methods that cannot provide data appropriate for addressing questions of causality ...

  2. Robert Lončarić, PhD in Geography

    Directory of Open Access Journals (Sweden)

    Damir Magaš

    2010-12-01

    Full Text Available On June 29, 2010, Robert Lončarić defended his PhD thesis Littoralisation of the Kvarner Islands – a Hydrogeographical Basis at the Department of Geography of the University of Zadar. Members of the Defence Committee  were Prof. Dr. Damir Magaš (mentor, Assoc. Prof. Dr. Martin Glamuzina, (Chairman and Prof. Dr. Ognjen Bonacci of the Faculty of Civil Engineering and Architecture in Split.

  3. Dražen Tutić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2009-12-01

    Full Text Available Dražen Tutić defended his PhD thesis Stereographic and Other Conformal Map Projections  for Croatia at the Faculty of Geodesy of the University of Zagreb on August 4, 2009. The thesis was evaluated by the Committee: Prof. Emeritus Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine (mentor and Prof. Dr. Dušan Petrovič from the Faculty of Civil and Geodetic Engineering of the University of Ljubljana.

  4. Analysis of information use in agricultural science PhD theses at Central University of Venezuela

    OpenAIRE

    Haparro-Martinez, Exio Isaac; Marzal, Miguel Ángel

    2008-01-01

    Purpose – To analyze information use in agricultural science PhD theses submitted between 1986 and 2002 in the Faculty of Agronomy, Central University of Venezuela (UCV). Design/methodology/approach – The source of information was the UCV Faculty of Agronomy, Library's database, “Tesis”. The unidimensional production and use indicators analyzed included: scientific production, reference density, self-citations, document contemporaneousness and type of documents cited, reference scatterin...

  5. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study. PMID:27455365

  6. Educating future nursing scientists: Recommendations for integrating omics content in PhD programs.

    Science.gov (United States)

    Conley, Yvette P; Heitkemper, Margaret; McCarthy, Donna; Anderson, Cindy M; Corwin, Elizabeth J; Daack-Hirsch, Sandra; Dorsey, Susan G; Gregory, Katherine E; Groer, Maureen W; Henly, Susan J; Landers, Timothy; Lyon, Debra E; Taylor, Jacquelyn Y; Voss, Joachim

    2015-01-01

    Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for the Advancement of Nursing Science's Idea Festival for Nursing Science Education, a work group charged with addressing omics preparation for the next generation of nursing scientists was convened. The purpose of this article is to describe key findings and recommendations from the work group that unanimously and enthusiastically support the incorporation of omics content into the curricula of PhD programs in nursing. The work group also calls to action faculty in schools of nursing to develop strategies to enable students needing immersion in omics science and methods to execute their research goals. PMID:26123776

  7. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  8. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  9. MS PHD'S: A successful model for reaching underrepresented minorities (URM) students through virtual platforms

    Science.gov (United States)

    Scott, O.; Johnson, A.; Williamson, V.; Ricciardi, L.; Jearld, A., Jr.; Guzman, W. I.

    2014-12-01

    To successfully recruit and retain underrepresented minority (URM) students and early career scientists, many programs supplement traditional curricular activities with multiple online platforms, establishing "virtual communities" that are free and easily accessible. These virtual communities offer readily sustainable opportunities to facilitate communication across a wide range of cultural lines and socioeconomic levels thereby broadening participation and inclusivity in STEM. Established in 2003, the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Earth System Science Professional Development Program has successfully used virtual community tools such as a listserv, community forum, social media, and VoIP technologies, to extend the face-to-face activities of the program and support the advancement of URM students and early career scientists in STEM. The use of multiple facets of virtual community by MS PHD'S participants supports and encourages "real life" interactions and mentorship, facilitates networking and professional development, and maintains continuity of shared networks. The program is now in its ninth cohort and supports 213 participants. To date, 54 participants have completed their PhD and another 61 are currently enrolled in doctoral programs.

  10. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Science.gov (United States)

    2013-05-31

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  11. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... changes in her ] that he found more ``attractive,'' such as how she was more prone to stay up late and... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant.... 52. Galvan told her that around noon he would pick up ``paperwork'' (a term that Det. Boyd...

  12. 75 FR 26993 - Alvin Darby, M.D.; Denial of Application

    Science.gov (United States)

    2010-05-13

    ... dependency on crack cocaine and `primo,' a mixture of cocaine and marijuana smoked together.'' GX 3, at 2... factors are * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I... application under section 303. See The Lawsons, Inc., 72 FR 74334, 74337 (2007); Anthony D. Funches, 64...

  13. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  14. Functional identification of MdSIZ1 as a SUMO E3 ligase in apple.

    Science.gov (United States)

    Zhang, Rui-Fen; Guo, Ying; Li, Yuan-Yuan; Zhou, Li-Jie; Hao, Yu-Jin; You, Chun-Xiang

    2016-07-01

    SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. In Arabidopsis, the AtSIZ1 protein is a SUMO E3 ligase that promotes the conjugation of SUMO proteins to target substrates. Here, we isolated and identified a SUMO E3 ligase, MdSIZ1, in apple, which was similar to AtSIZ1. SUMOylation analysis showed that MdSIZ1 had SUMO E3 ligase activity in vitro and in vivo. SUMO conjugation was increased by high temperatures, low temperatures, and abscisic acid (ABA). The ectopic expression of MdSIZ1 in Arabidopsis siz1-2 mutant plants partially complemented the morphological mutant phenotype and enhanced the levels of SUMO conjugation. Taken together, these results suggest that MdSIZ1-mediated SUMO conjugation of target proteins is an important process that regulates the adaptation of apple plants to various environmental stresses. PMID:27152458

  15. 77 FR 3185 - Proposed Establishment of Class E Airspace; Grasonville, MD

    Science.gov (United States)

    2012-01-23

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Grasonville, MD, providing the controlled airspace required to support the Copter RNAV GPS special...

  16. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2012-04-16

    ... Federal Register (73 FR 3316). ] Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  17. 78 FR 76322 - Thomas Neuschatz, M.D.; Decision and Order

    Science.gov (United States)

    2013-12-17

    ... of J.G.'s known addiction, ``but inaccurately represented this as a treatment for a chronic pain... her chronic pain rather than as treatment for her opioid addiction was patently false.'' Id. at 18...(f). ``These factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR...

  18. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  19. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  20. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows... Avenue) highway toll drawbridge across Bear Creek, mile 1.5, Sparrows Point, MD was replaced with a fixed... Bear Creek, mile 1.5 was removed and replaced with a fixed bridge in 1998. Prior to 1998, a...

  1. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  2. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  3. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  4. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  5. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  6. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  7. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  8. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-07-19

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 111). The NPRM stated... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  9. Lonely and hardworking : international PhD candidates cross-cultural adjustment at the University of Oslo

    OpenAIRE

    2010-01-01

    In recent years, the number of scholars that expatriate has increased, and with this also the number of scholars having to adjust to a new cultural environment. PhD candidates constitute an important part of this growth; yet, their cross-cultural experiences have not been studied accordingly. Hence, this study examines how international PhD candidates at the University of Oslo (UiO) characterize their experiences when adjusting to a new cultural environment. Furthermore, the study is also aim...

  10. The Need for Greater Support in Academic Writing for PhD Students in Mathematics and Related Subjects

    OpenAIRE

    Silvers, L. J.

    2014-01-01

    Within the United Kingdom (UK), the graduate student population in mathematics departments seeking to obtain the higher degree of Doctor of Philosophy (PhD) has become increasingly diverse as a result of a number of factors. This student body faces a variety of challenges that raise questions about what provisions universities should provide in order to give these students the greatest chance of a successful completion of their PhD programme. In this article I argue that universities shou...

  11. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  12. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  13. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  14. Registration of the Soft Red Winter Wheat Germplasm MD01W233-06-1 Resistant to Fusarium Head Blight

    Science.gov (United States)

    MD01W233-06-1 (Reg. No., PI ) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from a cross of ‘McCormick’/ ‘Choptank’ made in 2001. McCorm...

  15. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  16. Draft Genome Sequence of Ralstonia sp. MD27, a Poly(3-Hydroxybutyrate)-Degrading Bacterium, Isolated from Compost

    OpenAIRE

    Zhu, Morgan; McCully, Lucy M.; Silby, Mark W; Charles-Ogan, Tamunonengiyeofori I.; Huang, Jean; Brigham, Christopher J.

    2015-01-01

    Ralstonia sp. strain MD27, a novel biopolymer-degrading betaproteobacterium, was isolated from compost samples. This organism has been shown to utilize the biopolymer poly(3-hydroxybutyrate) [P(3HB)] as a carbon source for growth. We report the draft genome sequence of MD27 with an estimated total sequence length of 5.9 Mb.

  17. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  18. Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

    Science.gov (United States)

    Howell Smith, Michelle C.

    Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the

  19. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    Science.gov (United States)

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  20. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  1. MD5算法在档案管理系统中的应用%Application of MD5 Algorithm in File Management System

    Institute of Scientific and Technical Information of China (English)

    徐宝清; 赵乾宗

    2015-01-01

    along with the country to the information development and the culture education the increasing attention, the file man⁃agement system is becoming more and more popular. At the same time, with the increase of the amount of archives and the amount of users, the file management system is developing towards more automatic and humane direction.. In order to make the system more accord with the safety standards, the system will use MD5 encryption algorithm for user identity authentication.%随着国家对信息化发展和文化教育的日益重视,档案管理系统正变得越来越普及。与此同时,伴随着档案量和用户量的不断增加,档案管理系统也向着更加自动化和人性化的方向发展。为了使系统更加符合安全标准,系统将采用MD5加密算法对用户身份进行有效认证。

  2. Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.

    Science.gov (United States)

    Su, S; Cui, N; Li, J; Sun, P; Li, H; Li, Y; Cui, Z

    2016-07-01

    Marek's disease virus (MDV) GX0101 is a field strain of MDV with a naturally occurring insertion of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) fragment. Both copies of the meq gene were knocked out in the GX0101 bacterial artificial chromosome (BAC) clone to construct the recombinant virus SC9-1, resulting in a complete lack of pathogenicity and providing better protection against MD than CVI988/Rispens. In the present study, the BAC sequences in SC9-1 were removed using a cre-loxP system, and the virus termed SC9-2. SC9-2 showed a significant increase in replication in vitro and in vivo. There was a significant decrease in chicken weight, immune organ index, and antibody levels compared with those of SC9-1-inoculated chickens. The immune protection index of SC9-2 was similar to that of SC9-1, and the difference was not significant. The results of our studies demonstrate that the SC9-2 virus provides protection in specific pathogen free (SPF) chickens when challenged with a very virulent MDV rMd5, but it induces immunosuppressive effects in SPF chickens. PMID:26957626

  3. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  4. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  5. Destruction of medium already affected by destructive disorder: fibrillating atria conceptually need of therapeutic help rather than surgical or ablative destruction Credits: Dr. Petras Stirbys MD, PhD

    Directory of Open Access Journals (Sweden)

    Dr. Petras Stirbys MD, PhD

    2014-06-01

    Full Text Available Atrial fibrillation (AF as the most common supraventricular arrhythmia is scarcely amenable to contemporary treatment. Due to the diverse origin and variable clinical course of AF there is a broad spectrum of therapy options. However, optimal AF management has not become a gold standard yet. In general, the recurrence rate of AF is most often clinically unacceptable despite drug, surgical and/or ablation therapy. Substrate-based approach and ongoing ablation of atrial wall in its selected areas including the vicinity of pulmonary veins can be harmful. Applied physical factors do produce total disintegration of cardiomyocites – both intra- and inter-cellular damage which, in turn, leads to functional hypo-/inactivation of atria irrespective of whether the sinus rhythm is restored or not. In fact, iatrogenic phenomenon of ablation-induced atrial incompetence did emerge. Heterogeneity in clinical results reflects the uncertainty regarding the efficacy, risks and benefits of invasive AF therapy. In this regard the overall burden of AF may increase when using current therapy methods. Applicability of destructive techniques is yet to be fully elucidated and discussed. We hypothesize that currently used ablation and/or surgical techniques are potentially harmful since the success rates are likely achieved through violation of atrial myocardium. That is why a new and well-designed therapeutic strategy is needed. Invention of highly selective curative methods producing fibrillatory/electric blockage with concomitant saving of atrial transport function is to be encouraged.

  6. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    Science.gov (United States)

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC). PMID:26027580

  7. MD-portal: Highly Effective Website for Nuclear Materials Information Management

    International Nuclear Information System (INIS)

    A web-based system is widespread in not only everyday activities but also business fields. In past years, the systematic information of various properties of materials usually has been provided as tabulated documents; however it recently has been provided as web-based DB. There are many websites providing material properties information, representative examples include MatWeb from the United States, Granta MI from England and MatNavi from Japan. In 2003, the nuclear materials division in KAERI established a website about nuclear materials property DB, called MatDB. To inherit it, a website called MD-portal has been recently set up to release degradation information and various properties of nuclear materials. In this presentation, the structure and characteristics of MD-portal will be mentioned, and comments on its application will be given

  8. Role of Calcium Ion in Apoptosis of MD Cancer Cells Induced by Arsenic Trioxide

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiuli; WANG Jintao; XU Shiwen

    2008-01-01

    In order to observe the role of calcium ion in apoptosis of MD cancer cells induced by arsenic trioxide, inhibition percentage was detected by MTT assay;morphology changes were examined by fluorescence microscope;apoptosis was examined by DNA Ladder;[Ca2+]i was investigated by spectrofluorimeter in vitro on MDCC-MSB1 cells. The results showed that As2O3 inhibited the proliferation of MDCC-MSB1 cells in concentration dependent manner (P<0.05 or P<0.01);typical apoptosis character was observed by fluorescence microscope;DNA Ladder was observed;the [Ca2+]i was elevated significantly after the treatment of As203 (P<0.05 or P<0.01) and showed a dose-dependent manner. It is concluded that the calcium may play an important role in apoptosis of MD cancer cells induced by arsenic trioxide.

  9. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB)

    CERN Document Server

    Morisset, Christophe; Flores-Fajardo, Nahiely

    2014-01-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (Planetary Nebulae, H II regions, etc). Grid of models are performed to understand what are the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort of resolving both of these issues in the form of a database of photoionization models, easily accessible throught the MySQL protocol, and containing a lot of usefull outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  10. Employment Histories of Recent Astronomy Ph.D. Graduates from the University of Texas at Austin

    Science.gov (United States)

    Dinerstein, H.

    1996-12-01

    The University of Texas at Austin has one of the largest astronomy graduate programs in the U.S. As of several years ago, there were over 50 students enrolled, although the current number is closer to 35. During the decade 1980-89, a total of 85 students entered the program, of whom 64 (75%) completed the Ph.D. About a third (33%) of the Ph.D. graduates currently hold postdoctoral positions in astronomy. (Note that the sample includes some students who received their degrees within the last four or five years.) Another 35% hold permanent (or tenure-track) faculty jobs or positions at government laboratories or observatories in the U.S.; if one includes those who hold such positions in other countries, the total rises to 45%. (Some of these were foreign students who returned to their country of origin.) The remaining individuals are supported by grants (``soft money'') or are employed by companies doing work mostly unrelated to astronomy. Examination of the job histories and experiences of this cohort gives us crucial, realistic information on the present-day job market and prospects for professional success for new Ph.D.'s in astronomy. This is extremely important at a time when the American Astronomical Society and the profession at large is re-examining the effectiveness and goals of current graduate programs in astronomy. I report here results from a survey of this large cohort of recent graduates, including such information as the average number of postdocs held, and average number of years between receiving the Ph.D. and finding a permanent position in astronomy.

  11. Building Better Bridges: An Evaluation of The Bridge to the Ph.D. Program

    Science.gov (United States)

    Ellyn Sanderson, Robyn; Lobel, Caroline; Agueros, Marcel A.; Anderson, Vanessa; Ash, Summer; Purdie-Vaughns, Valerie; Romero-Canyas, Rainer; Walker, Erica

    2016-01-01

    Columbia University's Bridge to the Ph.D. in the Natural Sciences Program is increasing the number of underrepresented scholars entering graduate programs and equipping them to succeed in these programs. In a given year, three to five Bridge participants are hired as full-time Columbia University research assistants for up to two years. Now in its seventh year, the Program supports seven participants, and its alumni (including five astronomers) have gone on to Ph.D. programs across the country. Although to date fewer than 40 people have participated in the Program, a number too small for an exclusively statistical evaluation of its effectiveness, we are collecting invaluable longitudinal data on the career progressions of underrepresented aspiring scientists across the natural sciences. At least a dozen Bridge alumni will earn their Ph.D. in the next two-three years, and we will then learn much more about the impact that the Bridge Program has had on our participants' trajectories. Among other things, we hope to use these data to determine the Program's effectiveness in developing feelings of self-efficacy and participants' confidence in their ability to succeed in doctoral programs, to measure the rate at which Bridge alumni successfully complete doctoral programs relative to their peers, and to identify the aspects of the Program that participants find most helpful to their progress at different stages of their paths to and through doctoral programs. Here we describe the data we have already obtained as part of our on-going study, and preliminary results from our analysis.

  12. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    OpenAIRE

    Ravel, Jacques; Mazmanian, Sarkis K.

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research...

  13. Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

    International Nuclear Information System (INIS)

    Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

  14. MD/MBA Students: An Analysis of Medical Student Career Choice

    OpenAIRE

    Sherrill, Windsor Westbrook

    2009-01-01

    Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Me...

  15. Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

    International Nuclear Information System (INIS)

    The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

  16. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  17. A unified architecture of MD5 and RIPEMD-160 hash algorithms

    OpenAIRE

    Ng, CW; Ng, TS; Yip, KW

    2004-01-01

    Hash algorithms are important components in many cryptographic applications and security protocol suites. In this paper, a unified architecture for MD5 and RIPEMD-160 hash algorithms is developed. These two algorithms are different in speed and security level. Therefore, a unified hardware design allows applications to switch from one algorithm to another based on different requirements. The architecture has been implemented using Altera's EPF10K50SBC356-1, providing a throughput over 200Mbit...

  18. Measurement of the Mass Difference m(D_s^+) - m(D^+) at CDF II

    CERN Document Server

    Acosta, D; Ahn, M H; Akimoto, T; Albrow, M G; Alcorn, B; Alexander, C; Allen, D; Allspach, D H; Amaral, P; Ambrose, D; Amendolia, S R; Amidei, D; Amundson, J F; Anastassov, A; Anderson, J; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Asakawa, T; Ashmanskas, W; Attal, A; Avanzini, C; Azfar, F; Azzi-Bacchetta, P; Babik, M; Bacchetta, N; Bachacou, H; Badgett, W F; Bailey, S; Bakken, J; Barbaro-Galtieri, A; Bardi, A; Bari, M; Barker, G; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Barsotti, E; Basti, A; Bauer, G; Beckner, D; Bedeschi, F; Behari, S; Belforte, S; Bell, W H; Bellendir, G; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Berg, B; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bogdan, M; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bowden, M; Box, D; Bromberg, C; Brown, W; Brozovic, M; Brubaker, E; Buckley-Geer, L; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byon-Wagner, A; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canal, P; Canepa, A; Carithers, W C; Carlsmith, D; Carosi, R; Carrell, K; Carter, H; Caskey, W; Castro, A; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chandler, J T; Chapman, J; Chappa, S; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Cisko, S; Clark, A G; Coca, M; Coiley, K; Colijn, A P; Colombo, R M; Connolly, A; Convery, M; Conway, J; Cooper, G; Cordelli, M; Cortiana, G; Cranshaw, J; Cudzewicz, R; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Dal Monte, L; Da Ronco, S; D'Auria, S; Davila, R; Dawson, J; Dawson, T; De Barbaro, P; De Baun, C; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; De Maat, R; Demar, P; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Derylo, G; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donno, F; D'Onofrio, M; Dorigo, T; Downing, R; Drake, G; Drennan, C; Drollinger, V; Dunietz, Isard; Dyer, A; Ebina, K; Eddy, N; Ely, R; Engels, E; Erbacher, R D; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Fischler, M; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fromm, J; Fujii, Y; Furic, I; Galeotti, S; Galet, G; Gallas, A; Gallinaro, M; Ganel, O; García, C; García-Sciveres, M; Garfinkel, A F; Garwacki, M; Garzoglio, G; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Gerstenslager, J; Giacchetti, L; Giagu, S; Giannetti, P; Gibson, A; Gillespie, G; Gingu, C; Ginsburg, C; Giolo, K; Giordani, M; Glagolev, V; Glenzinski, D A; Glossen, R; Gold, M; Goldschmidt, N; Goldstein, D B; Goldstein, J; Gómez, G; Goncharov, M; González, H; Gordon, S; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Grado, J; Gregori, M; Gresele, A; Griffin, T; Grim, G; Grimm, C; Gromoll, S; Grosso-Pilcher, C; Gu, C; Guarino, V; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, A; Hahn, K; Hahn, S R; Halkiadakis, E; Hall, C; Handler, R; Haney, M; Hao, W; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington, J; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hawke, T; Hays, C; Heider, E; Heinemann, B; Heinrich, J; Heiss, A; Hennecke, M; Herber, R; Herndon, M; Herren, M; Hicks, D; Hill, C; Hirschbuehl, D; Höcker, A; Hoff, J; Hoffman, K D; Hoftiezer, J H; Holloway, A; Holloway, L E; Holm, S; Holmgren, D; Hou, S; Houlden, M A; Howell, J; Hrycyk, M; Hubbard, P; Hughes, R E; Huffman, B T; Humbert, J; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, I; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jetton, R; Johnson, M; Jones, M; Jones, T; Jun, S Y; Junk, T R; Kallenbach, Jeff; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kasha, H; Kasten, M; Kato, Y; Kemp, Y; Kennedy, R D; Kephart, K; Kephart, R D; Khazins, D; Khotilovich, V; Kilminster, B; Kim, B J; Kim, D H; Kim, H S; Kim, J; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirk, M; Kirsch, L; Klein, R; Klimenko, S; Knapp, M; Knoblauch, D; Knuteson, B; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kononenko, W; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A; Kovalev, A; Kowalkowski, J B; Kraus, J; Kravchenko, I V; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kumar, A; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lamore, D; Lancaster, J; Lancaster, M; Lander, R; Lanfranco, G; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lee, J; Lee, K; Lee, S W; Lei, C M; Leininger, M; Leonardi, G L; Leonardo, N; Leone, S; Levshina, T; Lewis, F; Lewis, J D; Li, K; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lobban, O; Lockyer, N S; Loginov, A; Loken, J; Loreti, M; Loskot, J; Loverre, P F; Lucchesi, D; Lukens, P; Lutz, P; Lyons, L; Lys, J; MacNerland, J; MacQueen, D; Madorsky, A; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Mammini, P; Manca, G; Mandrichenko, I V; Manea, C; Marginean, R; Marrafino, J; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mayer, J; Mayers, G M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Meyer, A; Miao, T; Michael, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Mizicko, D; Moccia, S; Moggi, A; Moggi, N; Montero, S; Moore, R; Moore, T; Morris, L; Morsani, F; Moulik, T; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Murgia, S; Nachtman, J; Nagaslaev, V; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Neuberger, D; Newby, W; Newcomer, F M; Newman-Holmes, C; Niell, F; Nielsen, J; Nicollerat, A S; Nigmanov, T; Niu, H; Nodulman, L; Noe, W; Österberg, K; Ogawa, T; Oh, S; Oh, Y D; Ohl, K; Ohsugi, T; Oishi, R; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Orr, S; Pagani, G; Pagliarone, C; Palmonari, F; Ramos, I; Panacek, S; Pantano, D; Paoletti, R; Papadimitriou, V; Pasetes, R; Pashapour, S; Passuello, D; Paterno, M; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pavlicek, V; Pavlon, S; Pellett, D; Penzo, Aldo L; Perington, B; Petragnani, G; Petravick, D; Phillips, T J; Photos, F; Piacentino, G; Picciolo, C; Piccoli, L; Piedra, J; Pitts, K T; Plunkett, R; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Profeti, A; Pronko, A G; Proudfoot, J; Punzi, G; Rademacker, J; Rafaelli, F; Rakitine, A; Rappoccio, S; Ratnikov, F; Rauch, J; Ray, H; Rechenmacher, R; Reia, S; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Riveline, M; Rivetta, C; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Román, M; Rosenberg, S I; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Sabik, S; Sadler, L; Safonov, A; Saint-Denis, R; Sakumoto, W K; Saltzberg, D; Sánchez, C; Sanders, H; Sanders, R; Sandrew, M; Sansoni, A; Santi, L; Sarkar, S; Sarraj, H; Sarraj, J; Sato, H; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, J; Schmidt, M P; Schmitt, M; Schmitt, R; Schmitz, M; Schofield, G L; Schuh, K; Schultz, K; Scodellaro, L; Scott, L; Scribano, A; Scuri, F; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shallenberger, J; Shapiro, M D; Shaw, T; Shears, T G; Shenai, A; Shepard, P F; Shimojima, M; Shochet, M J; Shon, Y; Shoun, M; Sidoti, A; Siegrist, J L; Sieh, C; Siket, M; Sill, A; Silva, R; Simaitis, V; Sinervo, P; Sirotenko, V I; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Stadie, H; Stanek, R; Stanfield, N; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Stuermer, W; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Syu, J; Szymulanski, A; Taffard, A C; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tamburello, P; Tanaka, M; Tanaka, R; Tang, D; Tanimoto, N; Tannenbaum, B; Tapprogge, Stefan; Taylor, R D; Teafoe, G; Tecchio, M; Teng, P K; Terashi, K; Terentieva, T; Tesarek, R J; Tether, S; Thom, J; Thomas, A; Thompson, A S; Thomson, E; Thurman-Keup, R M; Timm, S; Tipton, P; Tkaczyk, S M; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torretta, D; Trimby, C; Trischuk, W; Trumbo, J; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, T; Van Berg, R; Varganov, A V; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vittone, M; Voirin, J; Vollmer, B; Vollrath, I; Volobuev, I P; Von der Mey, M; Votava, M; Wagner, R G; Wagner, R L; Wagner, W; Wallace, N; Walter, T; Walters, A; Wan, Z; Wandersee, A; Wang, M J; Wang, S M; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Weems, L; Wenzel, H; Wester, W; Whitehouse, B; Wickenberg, W; Wicklund, A B; Wicklund, E; Wigmans, R; Wike, C; Wilkes, T; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Wong, M; Worcester, M; Worland, R; Worm, S; Wright, T; Wu, J; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yarema, R J; Yeh, G P; Yi, K; Yocum, D R; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zalokar, M; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zimmerman, T; Zsenei, A; Zucchelli, S

    2003-01-01

    We present a measurement of the mass difference m(D+_s) - m(D+), where both the D+_s and D+ are reconstructed in the phi pi+ decay channel. This measurement uses 11.6 pb-1 of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be: 99.41 +- 0.38 (stat) +- 0.21 (syst) MeV/c^2.

  19. Dr René Favaloro (1923-2000) Rene Favaloro MD (1923-2000)

    OpenAIRE

    Sergio Morán V

    2000-01-01

    René Favaloro MD, was born in La Plata, Argentina, in July 1923. He studied medicine in La Plata and made his cardiology residence in the Cleveland Clinic, where he developed coronary bypass surgery for the treatment of ischemic heart disease. At the present time, this surgical procedure is a well recognized therapy for coronary artery disease that has benefited millions of patients. Back in Argentina, he founded in 1992 the Institute of Cardiology and Cardiovascular Surgery that had an impor...

  20. Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX) for Bionanosystem Simulations

    OpenAIRE

    Miao, Yinglong; Ortoleva, Peter J.

    2009-01-01

    A multiscale approach, Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX), to the all-atom simulation of large bionanosystems is presented. The approach starts with the introduction of a set of order parameters (OPs) automatically generated with orthogonal polynomials to characterize the nanoscale features of bionanosystems. The OPs are shown to evolve slowly via Newton’s equations and the all-atom multiscale analysis (AMA) developed earlier1 demonstrates the existence of their stochas...

  1. Why is mu/md so much smaller than mc/ms and mt/mb?

    International Nuclear Information System (INIS)

    We propose that the smallness of mu/md is due to the ''wrong'' Yukawa coupling of the up quark in a two-Higgs-doublet model. The model has natural flavor conservation only among charges -1/3 quarks and leptons. We estimate that D0-bar D 0 mixing is much larger than the value of the standard-model box diagrams, and could be larger than or comparable to the long-distance contributions,

  2. It's time for a change in the way we educate physiology PhD candidates.

    Science.gov (United States)

    Tallitsch, R B

    1996-12-01

    Graduate students in physiology programs today are faced with a job market that is significantly different from that which many of us faced 25, 10, or even 5 years ago. As a result, physiology educators need to change the content and style of their programs to prepare graduates for their futures. Programs must continue to prepare graduates for research postdoctoral positions, but they also should prepare them for employment at smaller institutions that have higher teaching demands and that encourage, but do not require, research. Changes are suggested in the way PhD candidates are taught and in the way professors mentor students seeking employment at smaller institutions. PMID:8997411

  3. Take control of your PhD journey! Erfaringer fra et skreddersydd undervisningsopplegg

    OpenAIRE

    Andreassen, Helene N.; Aspaas, Per Pippin

    2015-01-01

    Universitetsbiblioteket ved UiT Norges arktiske universitet avholdt våren 2015 en seminarrekke for PhD-studenter, «Take control of your PhD journey: From (p)reflection to publishing». Seminaret besto av fire deler: 1) akademisk integritet, plagiat og forskningens samfunnsrolle; 2) litteratursøk i databaser for ulike fagdisipliner; 3) referansehåndteringsverktøyet EndNote; 4) publisering, særlig Open Access. Vi ønsker å dele erfaringer fra vårt kurs og få innspill fra andre som har lignende er...

  4. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    Directory of Open Access Journals (Sweden)

    Camelia Popa

    2013-03-01

    Full Text Available As a whole, this PhD thesis follows three research lines, namely: (1 the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2 the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3 the line of an awareness of the need to prevent and fight against the effects arising from money laundering processes, the national and international efforts taken until present nation- and worldwide and the future measures required to diminish the consequences of this scourge.

  5. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    OpenAIRE

    Xiaoli Wang

    2016-01-01

    Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZen...

  6. Researcher Profile: An Interview with Sonya Britt, Ph.D., CFP, AFC

    OpenAIRE

    Sonya Britt

    2013-01-01

    Sonya Britt, Ph.D., CFP, AFC graduated from Texas Tech University in 2010 with a doctorate in Personal Financial Planning. Her first two degrees are from Kansas State University in Personal Financial Planning (B.S.) and Marriage and Family Therapy (M.S.). and she was the founding president of the Financial Therapy Association and recently retired from the board as past-president. She currently serves on the board of the American Council on Consumer Interests association. Sonya is an associate...

  7. Structure, function and regulation of jade family PHD finger 1 (JADE1).

    Science.gov (United States)

    Panchenko, Maria V

    2016-09-01

    The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. Recent discoveries of JADE1 function in the regulation of the epithelial cell cycle with potential relevance to disease are presented. Unresolved questions and future directions are formulated. PMID:27155521

  8. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R)

    OpenAIRE

    John Grable

    2014-01-01

    John E. Grable, Ph.D., CFP(R) teaches and conducts research in the Certified Financial Planner(TM) Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research i...

  9. The first Italian doctorate (PhD Course) in Physics Education Research

    Science.gov (United States)

    Michelini, Marisa; Santi, Lorenzo

    2008-05-01

    The first PhD Italian course in Physics Education Research in Udine aims to qualify young researchers and teachers coming from all the Italian groups of research in the field. It becomes a context for developing research projects carried out following parallel research lines on: Teaching/Learning paths for didactic innovation, cognitive research, ICT for strategies to overcome conceptual knots in physics; E-learning for personalization; d) Computer on-line experiments and modelling; e) Teacher formation and training; f) Informal learning in science.

  10. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  11. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Agrawal

    2013-09-01

    Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

  12. Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment

    Science.gov (United States)

    Wernham, Madelaine; Jarrett, Pamela G.; Stewart, Connie; MacDonald, Elizabeth; MacNeil, Donna; Hobbs, Cynthia

    2014-01-01

    Background The assessment of fitness to drive in patients with cognitive impairment is complex. The SIMARD MD was developed to assist with assessing fitness to drive. This study compares the clinical decision made by a geriatrician regarding driving with the SIMARD MD score. Methods Patients with a diagnosis of mild dementia or mild cognitive impairment, who had a SIMARD MD test, were included in the sample. A retrospective chart review was completed to gather diagnosis, driving status, and cognitive and functional information. Results Sixty-three patients were identified and 57 met the inclusion criteria. The mean age was 77.1 years (SD 8.9). The most common diagnosis was Alzheimer’s disease in 22 (38.6%) patients. The mean MMSE score was 24.9 (SD 3.34) and the mean MoCA was 19.9 (SD 3.58). The mean SIMARD MD score was 37.2 (SD 19.54). Twenty-four patients had a SIMARD MD score ≤ 30, twenty-eight between 31–70, and five scored > 70. The SIMARD MD scores did not differ significantly compared to the clinical decision (ANOVA p value = 0.14). Conclusions There was no association between the SIMARD MD scores and the geriatricians’ clinical decision regarding fitness to drive in persons with mild dementia or mild cognitive impairment. PMID:24883164

  13. Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

    Directory of Open Access Journals (Sweden)

    Aruna Rajan

    Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

  14. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gyeonggeun; Kil, Soyeon; Kwon, Junhyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs.

  15. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    International Nuclear Information System (INIS)

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs

  16. The Algorithm Design for Preventing URL Modified Based on MD5%基于MD5的URL防篡改算法设计

    Institute of Scientific and Technical Information of China (English)

    刘国卿

    2011-01-01

    针对常用的URL篡改攻击,提出了一种基于MD5加密的URL防篡改算法。该算法将一段哈希代码作为校验码附加到目标URL后,在页面逻辑运行完成前采用过滤器实现校验码的比对,从而完成URL是否被篡改的判断;最后,基于.NET平台实现了新链接生成模块和校验模块,并讨论了模块的部署。%For preventing URL modified, this paper proposed a algorithm design, which could be used to cheek out the modification of URL efficiently. The algorithm adds a hashed MAC to order URL,it makes it posible to learn whether the URL he modified. Furthermore,

  17. 基于MD5加密的Tornado码复制算法改进%An improved algorithm based on MD5 encryption Tornado code

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.%基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。

  18. An improved algorithm based on MD5 encryption Tornado code%基于MD5加密的Tornado码复制算法改进

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。%Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.

  19. The application of MD5 algorithm in telephone speech system software protection%MD5算法在电话语音系统软件保护中的应用

    Institute of Scientific and Technical Information of China (English)

    段青玲; 杨仁刚; 李辉

    2007-01-01

    本文首先对软件保护技术进行了简要的概述,在剖析MD5算法工作原理的基础上,提出了基于MD5加密算法的软件硬加密保护方案.该方案根据机器的CPU序列号和语音卡号使用MD5加密算法自动生成软件序列号,并对MD5加密算法的输入输出数据进行变化处理.结果显示,该方法实现了"一机一码",并已应用于某"电话语音系统"中.

  20. MD5报文摘要算法与文件系统完整性保护%MD5 Message Digest Algorithm and Protection of File System Integrity

    Institute of Scientific and Technical Information of China (English)

    李杰; 张学旺

    2003-01-01

    MD5报文摘要算法是一种应用广泛的提取数字指纹的算法.文件系统完成性保护利用MD5算法产生文件或对象的数字指纹以识别它们的微小变化而实施保护.本文详细剖析了MD5算法的工作原理,以及基于MD5算法的文件系统完整性检查程序的原理、设计和实现.

  1. A Greedy Algorithm to solve md-MST Problem Based on Edgeexchange%一种基于边交换的贪心算法求解md-MST问题

    Institute of Scientific and Technical Information of China (English)

    赵磊; 刘辉; 魏书堤; 陈坚祯; 林睦纲

    2015-01-01

    通过对最小度限制最小生成树(md-MST)问题性质进行分析,提出了一种基于边交换的贪心算法.算法先用贪心算法生成一棵生成树ST,然后对生成树ST经过边交换调整,得到满足问题约束条件的可行解,再对生成树ST进行进一步边交换优化,得到md-MST问题的最优解或接近最优解的近似解.实验证明,算法能在短时间内求出大规模顶点随机图的md-MST,是一种非常实用的求解md-MST问题的精确算法.

  2. An Analysis of Gender Differences in Recent Earth and Space Science PhD Graduates

    Science.gov (United States)

    Giesler, J.

    2001-12-01

    The American Geophysical Union (AGU) and the American Geological Institute (AGI) have been collecting data on recent PhDs in the geosciences for 5 years (1996-2000). The 1999-2000 PhD classes were combined for an increased sample size and analyzed for gender differences. Other than salary, place of employment, and job search methodology no differences were found. Females had salaries that were slightly lower than those of their male counterparts. This might be due to the fact that there are a greater number of female postdoctoral candidates 47% compared to males 40%. Place of employment tended to be similar with fewer women in industry and a higher number of recent female PhD graduates in the academic sector. Interestingly, men and women differed in the ways in which they found their first job. A higher percent of men reported they felt their advisor was helpful in their job search (52% for men and 50% for women). Women used electronic resources at a higher rate (17.3%) than men (12.1%) and 33.6% of the women felt their scientific society was helpful in their job search, compared to only 24.1% of the men.

  3. Identifying Barriers and Facilitators to Nurse Faculty Careers for PhD Nursing Students.

    Science.gov (United States)

    Fang, Di; Bednash, Geraldine D; Arietti, Rachael

    2016-01-01

    The shortage of doctorally educated nurses pursuing faculty careers is a major concern regarding the development of the nurse faculty workforce. This cross-sectional study aims to identify barriers and facilitators to academic careers for doctoral (PhD) nursing students. A total of 1,500 PhD students were randomly selected from nursing schools across the country to participate in our survey, and a 62.8% response rate was achieved. The study found that 72% of respondents planned to pursue faculty careers after graduating. Students with postgraduation plans for academic careers, nonacademic careers, and undecided careers showed distinct profiles of demographic and academic characteristics. They also perceived facilitators and barriers to faculty careers differently. The most influential facilitators were interest in teaching and an appreciation of the impact of nursing research on patient care, and the most considered barriers were poor financial compensation and a negative perception of academia. Minority students were more likely than White students to have plans for academic careers. Various experiences during doctoral education appeared to have a positive impact on students' decisions to pursue academic careers. PMID:27216127

  4. First ‘Gentner Doktor’ finishes PhD at CERN

    CERN Multimedia

    Jordan Juras

    2011-01-01

    In 2007, the CERN Doctoral Student Programme saw the addition of the Gentner Doctoral Student Programme, named in honour of the celebrated nuclear physicist, Wolfgang Gentner. Four years later, on 22 June 2011, Marcel Schuh finished his PhD with a thesis in the field of accelerator technology and became the very first ‘Gentner Doktor’.   Marcel Schuh, first 'Gentner Doktor', celebrates completing his PhD. (Photo by Carsten P. Welsch) Marcel Schuh became a Gentner student in April 2008, after completing a physics degree in 2007 at the University of Heidelberg. His thesis allowed him to gain exposure to CERN and the LHC, as he worked on monitoring and control systems for trigger and readout electronics on the ALICE detector at the LHC. With the support of university supervisor, Carsten P. Welsch, Schuh applied for a Gentner Doctoral Studentship on the Superconducting Proton Linac (SPL) project. “My task was to evaluate whether dedicated higher order mode (HOM) coupler...

  5. The Science Impact of Astronomy PhD Granting Departments in the United States

    CERN Document Server

    Kinney, Anne L

    2008-01-01

    The scientific impact of the research of 36 astronomy PhD granting departments is measured and ranked here. Because of the complex nature of Universities, this study looks at the Universities in two ways; first analyzing the impact of the published work over a 10 year period of the Department which grants the PhD and; second, looking at the impact of the published work as a whole including Laboratories, Centers, and Facilities. The Universities considered in the study are drawn from the 1992 NRC study on Programs of Research, Doctorate in Astrophysics and Astronomy with three Universities added. Johns Hopkins, Michigan State, and Northwestern all host substantial astronomical research within their Departments of Physics and Astronomy and so are included here. The first method of measuring impact concentrates on tenured and tenured track faculty, with the top quartile being 1. Caltech, 2. UC Santa Cruz, 3. Princeton, 4. Harvard, 5. U Colorado, Boulder, 6. SUNY, Stony Brook, 7. Johns Hopkins, 8. Penn State, and...

  6. A Method that Preventing URL Attack Based on MD5 Encryption Algorithm%一种采用MD5加密算法防止URL攻击的方法

    Institute of Scientific and Technical Information of China (English)

    张杰; 李华伟; 周立军

    2011-01-01

    在简要分析当前URL攻击手段的基础上,提出一种使用MD5加密算法有效防止URL攻击的方法,按照URL合法性检测流程,设计基于Java MVC轻量级框架Struts的测试方案,比较MD5和DES算法在URL参数加密过程中的性能.

  7. Modelling research: a collaborative approach to helping PhD students develop higher-level research skills

    Science.gov (United States)

    Garcia-Perez, Alexeis; Ayres, Robert

    2012-06-01

    A high proportion of PhD candidates in science and engineering fail to complete their degrees. This paper reports the results of a series of workshops where experienced researchers and supervisors were brought together with PhD students to discuss and develop a model of the PhD process. The objective was to help students develop a more rounded and thoughtful approach to their work. The impact of the workshops was assessed by carrying out structured interviews and coding the results to determine the impact on participant perceptions. The analysis suggests that the approach is effective in helping participants to clarify their thinking about the research process in which they are engaged. A proportion of participants appear to have moved from a tactical to a more strategic approach to their research. The study involved students in a postgraduate university but has implications for training of all research students in applied disciplines.

  8. COMPARISON OF RESEARCH ENGAGEMENT OF PHD STUDENTS AT VARIOUS STUDY PROGRAMS AT CULS PRAGUE: AN INTRODUCTORY STUDY

    Directory of Open Access Journals (Sweden)

    FLÉGL, Martin

    2014-12-01

    Full Text Available In an attempt to improve the quality of doctoral studies and the satisfaction of PhD students at the Czech University of Life Sciences Prague (CULS Prague the authors disseminated online questionnaire among all PhD students in May and June 2014. The questionnaire covered areas related to doctoral study, PhD supervisors, doctoral scholarship, research publications, and last but not least, to satisfaction with the doctoral study. In this article responses related to research, such as allocation of time to doctoral studies, allocation of time to research, involvement in research projects and satisfaction with research outputs. The authors provide comparison of all above mentioned domains according to faculties as well as form of doctoral studies at CULS Prague.

  9. Application of MD5 Encryption Algorithm in Registration and Login Verification Module%MD5加密算法在注册及登录验证模块中的应用

    Institute of Scientific and Technical Information of China (English)

    周小红; 周建伙

    2015-01-01

    With the development of Internet technology,information security is becoming more and more popular.This pa-per introduces the basic principle of the MD5 encryption algorithm.The application of MD5 encryption algorithm in the regis-tration and login verification module in the.NET environment through Visual C# is introduced in detail.The security of MD5 al-gorithm is analyzed.Final y,put forward and realize the improvement method.%随着互联网技术的发展,信息安全越来越受到人们的关注。介绍了MD5加密算法的基本原理,详细介绍如何在。 NET环境下通过Visual C#实现MD5加密算法在注册及登录验证模块中的应用。分析MD5算法的安全性,最后提出并实现自己的改进方法。

  10. MD5加密算法改进及其特征码在杀毒软件中的应用%An improved MD5 encryption algorithm and application in anti-virus software

    Institute of Scientific and Technical Information of China (English)

    贾晓强

    2015-01-01

    文章分析了MD5算法发展、危机、碰撞分析并加入"盐值"对算法做了改进,然后给出了其C++的具体实现算法;分析MD5特征码的特点构建了特征库配置文件,用VC实现了基于特征码的杀毒软件,此软件能根据文件特征码(MD5值)成功删除可疑文件。%The paper analyzed the development, crisis and the collision of the MD5 algorithm,by adding the"salt value", the algorithm has been improved. And then gived the concrete implementation of the algorithm with c++language;Analysis of the characteristics of the MD5 signature feature ,database configuration file is constructed, using VC implementation anti-virus software based on signature feature, the software can according to the file signature (MD5 value) successfully delete suspicious files.

  11. The Road to Become a Legitimate Scholar: A Case Study of International PhD Students in Science and Engineering

    Directory of Open Access Journals (Sweden)

    Pia Bøgelund

    2015-11-01

    Full Text Available The purpose of the doctoral education process is to create and legitimize scholarly researchers. This transformation, from student to scholar, is widely discussed in the literature. However, recent rapid changes in university culture have resulted in less time for supervision, stricter completion deadlines, and a greater focus on efficiency and productivity. This has had an impact on this transition process, and this impact has not been widely studied. The aim of this article is to understand the consequences of the current trends for PhD students and the education of PhD students in general. The article is based on interviews with 14 international students from two different research programs at the Faculty of Engineering and Science at Aalborg University in Denmark. The case of international PhD students in a western setting is singled out as a challenging case for becoming a legitimate scholar, since they face the additional challenge of becoming socialised into their new foreign setting. Overall, the study concludes that the transition process of doctoral students is affected by the way different supervisors deal with current university trends and how PhD students fit or do not fit into their knowledge production practices. The study identifies matches or mismatches in a knowledge production perspective, quality of contact, and degree of independence of the PhD student as factors that influence whether a transition process can be marked as sound, troublesome, or lacking. Finally, the study identifies an overall risk of neglecting the more interdependent types of international PhD students. Suggestions are given as how to address this risk.

  12. The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.

    Directory of Open Access Journals (Sweden)

    Nada Lallous

    Full Text Available The human UHRF1 protein (ubiquitin-like containing PHD and RING finger domains 1 has emerged as a potential cancer target due to its implication in cell cycle regulation, maintenance of DNA methylation after replication and heterochromatin formation. UHRF1 functions as an adaptor protein that binds to histones and recruits histone modifying enzymes, like HDAC1 or G9a, which exert their action on chromatin. In this work, we show the binding specificity of the PHD finger of human UHRF1 (huUHRF1-PHD towards unmodified histone H3 N-terminal tail using native gel electrophoresis and isothermal titration calorimetry. We report the molecular basis of this interaction by determining the crystal structure of huUHRF1-PHD in complex with the histone H3 N-terminal tail. The structure reveals a new mode of histone recognition involving an extra conserved zinc finger preceding the conventional PHD finger region. This additional zinc finger forms part of a large surface cavity that accommodates the side chain of the histone H3 lysine K4 (H3K4 regardless of its methylation state. Mutation of Q330, which specifically interacts with H3K4, to alanine has no effect on the binding, suggesting a loose interaction between huUHRF1-PHD and H3K4. On the other hand, the recognition appears to rely on histone H3R2, which fits snugly into a groove on the protein and makes tight interactions with the conserved aspartates D334 and D337. Indeed, a mutation of the former aspartate disrupts the formation of the complex, while mutating the latter decreases the binding affinity nine-fold.

  13. Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

    Directory of Open Access Journals (Sweden)

    Kevin J Paik

    Full Text Available The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1α is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological half-life of less than five minutes. Here we investigated the therapeutic potential of inhibiting HIF-1α degradation through short hairpin RNA silencing of PHD-2 in the setting of diabetic wounds and limb ischemia. Treatment of diabetic mouse fibroblasts with shPHD-2 in vitro resulted in decreased levels of PHD-2 transcript demonstrated by qRT-PCR, higher levels of HIF-1α as measured by western blot, and higher expression of the downstream angiogenic genes SDF-1 and VEGFα, as measured by qRT-PCR. In vivo, shPHD-2 accelerated healing of full thickness excisional wounds in diabetic mice compared to shScr control, (14.33 ± 0.45 days vs. 19 ± 0.33 days and was associated with an increased vascular density. Delivery of shPHD-2 also resulted in improved perfusion of ischemic hind limbs compared to shScr, prevention of distal digit tip necrosis, and increased survival of muscle tissue. Knockdown of PHD-2 through shRNA treatment has the potential to stimulate angiogenesis through overexpression of HIF-1α and upregulation of pro-angiogenic genes downstream of HIF-1α, and may represent a viable, non-viral approach to gene therapy for ischemia related applications.

  14. 浅谈六种加密算法之三——MD5算法

    Institute of Scientific and Technical Information of China (English)

    周庆

    2005-01-01

    MD5的全称是“nessage-digest algorithm 5”(信息-摘要算法),它是90年代初由MIT计算机科学实验室和RSA Data Security Inc联合开发,并经过MD2、MD3和MD4逐渐演变而来的。其主要作用是让大容量信息在用数字签名软件签署私人“密匙”前被“压缩”成一种保密的格式(就是把一个任意长度的字符串转变成一定长度的大整数),

  15. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Science.gov (United States)

    2010-07-01

    ... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point Wharf... located at Reedy Point and Old Town Point Wharf. These traffic lights are described in the rules...

  16. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference

    OpenAIRE

    C. SEGRÉ

    2010-01-01

    The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19–21 May 2010 http://www.semm.it/events_researchPast.php The Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe. The core participanting institutes ...

  17. Seismicity patterns before MD >= 4.1 earthquakes in the Friuli-Venezia Giulia (northeastern Italy) and western Slovenia areas

    OpenAIRE

    Gentili, Stefania; Bressan, Gianni

    2007-01-01

    International audience The spatial-temporal pattern of seismicity, preceding 5 moderate-sized earthquakes with MD ≥ 4.1, that occurred in the Friuli-Venezia Giulia region (northeastern Italy) and in western Slovenia, is investigated with the Region-Time-Length (RTL) and the PI algorithms. These algorithms were originally formulated to reveal the variation of seismicity patterns before large earthquakes. The RTL algorithm detects seismic quiescences before the 1996 Claut earthquake (MD 4.3)...

  18. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    OpenAIRE

    Jagdish Prasad Agrawal; Mandira Shahi

    2013-01-01

    Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6) MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC) of Institute of Medicine, Maharajgu...

  19. Message Digest Algorithm 5 Apply in PHP+MYSQL%MD5算法在PHP+MYSQL中的应用

    Institute of Scientific and Technical Information of China (English)

    苟玮; 姚旺生; 郭福亮

    2007-01-01

    在以web形式提供服务的系统中,用户从浏览器登录服务器数据库时,信息的安全性至关重要.主要讨论MD5算法在PHP+MYSQL中的应用,分析MD5算法的不足并提出了解决方法.

  20. House M.D.: the monitoring of life, crime and disease in the age of its technical visuality

    OpenAIRE

    Ivana Bentes

    2011-01-01

    When the body, the subjectivity and disease are converted into medical information, statistics and ballistics, MRI, contrasts, maps and images, they appear as new actors and dramatic elements in contemporary fiction, especially in series as House M.D. and CSI. In this article, we analyze some House M.D. episodes, highlighting how these body visualization technologies, genetic mapping, diagnostics, monitoring procedures, equipment for production of evidences of every kind (medical and criminal...

  1. The MD Design - a cool concept for geologic disposal of radioactive waste

    International Nuclear Information System (INIS)

    The scheduled disposal capacity for spent nuclear fuel and other high-level radioactive wastes (HLW) is inadequate and the estimated supply of recoverable uranium for continued nuclear energy production is scarce in the beginning of the 21st century. Hence, the development of a safe method for permanent disposal of HLW is an imminent global imperative to the continued development and use of nuclear energy, as is the prudent use of available uranium resources. However, permanent disposal of HLW poses a potential long-term public health and environmental hazard (risk) presenting unprecedented scientific challenges as well as moral, ethical and political concerns. The Minimum Disturbance to the Geologic Setting (MD) Design is an integrated, generic, low-temperature (cool), cradle-to-grave, radioactive waste management system for safe geologic disposal of radioactive waste. The application of the MD Design introduced in this paper is a safe and cost-effective geologic repository for permanent disposal of HLW. The main safety features are: Highly focused site selection and site characterization; mechanical mining; maximum near-field geologic setting temperature of 90 degrees Centigrade (degrees C) (194 degrees Fahrenheit [degrees F]); long-term primary (substantial) radionuclide containment by the engineered barriers system (EBS); long-term near-field monitoring; and a three-tiered licensing process. The main cost-effective features are: Concurrent construction and operation; remote controlled handling and in-room emplacement of HLW; and ready long-term access to the emplaced HLW. The unique combination of new and old safety and HLW disposal concepts in the MD Design offers potential solutions to three global HLW disposal problems; credible validation of safety assessments; enhanced HLW disposal capacity; and ready long-term access to a reusable, scarce natural energy resource - uranium

  2. Constant-pH MD Simulations of an Oleic Acid Bilayer.

    Science.gov (United States)

    Vila-Viçosa, Diogo; Teixeira, Vitor H; Baptista, António M; Machuqueiro, Miguel

    2015-05-12

    Oleic acid is a simple molecule with an aliphatic chain and a carboxylic group whose ionization and, consequently, intermolecular interactions are strongly dependent on the solution pH. The titration curve of these molecules was already obtained using different experimental methods, which have shown the lipid bilayer assemblies to be stable between pH 7.0 and 9.0. In this work, we take advantage of our recent implementations of periodic boundary conditions in Poisson-Boltzmann calculations and ionic strength treatment in simulations of charged lipid bilayers, and we studied the ionization dependent behavior of an oleic acid bilayer using a new extension of the stochastic titration constant-pH MD method. With this new approach, we obtained titration curves that are in good agreement with the experimental data. Also, we were able to estimate the slope of the titration curve from charge fluctuations, which is an important test of thermodynamic consistency for the sampling in a constant-pH MD method. The simulations were performed for ionizations up to 50%, because an experimentally observed macroscopic transition to micelles occurs above this value. As previously seen for a binary mixture of a zwitterionic and an anionic lipid, we were able to reproduce experimental results with simulation boxes usually far from neutrality. This observation further supports the idea that a charged membrane strongly influences the ion distribution in its vicinity and that neutrality is achieved significantly far from the bilayer surface. The good results obtained with this extension of the stochastic titration constant-pH MD method strongly supports its usefulness to sample the coupling between configuration and protonation in these types of biophysical systems. This method stands now as a powerful tool to study more realistic lipid bilayers where pH can influence both the lipids and the solutes interacting with them. PMID:26574431

  3. The scope and variety of combined baccalaureate-MD programs in the United States.

    Science.gov (United States)

    Eaglen, Robert H; Arnold, Louise; Girotti, Jorge A; Cosgrove, Ellen M; Green, Marianne M; Kollisch, Donald O; McBeth, Dani L; Penn, Mark A; Tracy, Sarah W

    2012-11-01

    The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their evolving role and potential impact.In 2011, using a definition of baccalaureate-MD program built on prior research, the authors reviewed Association of American Medical Colleges sources and medical school Web sites to identify and characterize 81 active programs. In addition, they surveyed the 57 medical schools offering those programs; 31 schools with 39 programs responded. The resulting database inventories the number and distribution of programs; institutional affiliations; missions or goals; length; size; admissions criteria; curricula; and retention requirements.Since the inception of combined programs in 1961, their number and curricular length have increased. Pressures that spurred earlier programs remain evident in the goals of today's programs: attract talented high school or early college students, especially from diverse backgrounds; prepare physicians to meet societal needs; and offer an enriched premedical environment. Baccalaureate educational activities achieve program goals through special courses, medical experiences, community service, and learning communities tailored to students' needs. Admission and retention criteria are comparable to those of traditional medical schools.Combined baccalaureate-MD programs have evolved along several paths during the last half century and have enriched the baccalaureate experiences of medical students. Shifting expectations for the selection and education of future physicians warrant focused research on these programs to document their effectiveness in addressing those expectations. PMID:23018320

  4. Understanding the mechanism of LCST phase separation of mixed ionic liquids in water by MD simulations.

    Science.gov (United States)

    Zhao, Yuling; Wang, Huiyong; Pei, Yuanchao; Liu, Zhiping; Wang, Jianji

    2016-08-17

    Recently, it has been found experimentally that two different amino acid ionic liquids (ILs) can be mixed to show unique lowest critical solution temperature (LCST) phase separation in water. However, little is known about the mechanism of phase separation in these IL/water mixtures at the molecular level. In this work, five kinds of amino acid ILs were chosen to study the mechanism of LCST-type phase separation by molecular dynamics (MD) simulations. Toward this end, a series of all-atom MD simulations were carried out on the ternary mixtures consisting of two different ILs and water at different temperatures. The various interaction energies and radial distribution functions (RDFs) were calculated and analyzed for these mixed systems. It was found that for amino acid ILs, the -NH2 or -COOH group of one anion could have a hydrogen bonding interaction with the -COO(-) group of another anion. With the increase of temperature, this kind of hydrogen bonding interaction between anions was strengthened and then the anion-H2O electrostatic interaction was weakened, which led to the LCST-type phase separation of the mixed ILs in water. In addition, a series of MD simulations for [P6668]1[Lys]n[Asp]1-n/H2O systems were also performed to study the effect of the mixing ratio of ILs on phase separation. It was also noted that the experimental critical composition corresponding to the lowest critical solution temperature was well predicted from the total electrostatic interaction energies as a function of mole fraction of [P6668][Lys] in these systems. The conclusions drawn from this study may provide new insight into the LCST-type phase behavior of ILs in water, and motivate further studies on practical applications. PMID:27498928

  5. Are MS in Economics Programs in Departments That Also Have a PhD Program in Economics Different from Their Counterparts?

    Science.gov (United States)

    Milkman, Martin I.; Marjadi, Riza; McCoy, James P.

    2016-01-01

    This is the first article that compares terminal master's degree programs in economics from universities that have a PhD program in economics with those that do not offer PhD programs in economics. The authors compare these differences based on surveys in 2002 and 2012. They examine differences in general program characteristics, department…

  6. Direct MD simulation of liquid-solid phase equilibria for two-component plasmas

    OpenAIRE

    Schneider, A. S.; Hughto, J.; Horowitz, C. J.; Berry, D. K.

    2011-01-01

    We determine the liquid-solid phase diagram for carbon-oxygen and oxygen-selenium plasma mixtures using two-phase MD simulations. We identified liquid, solid, and interface regions using a bond angle metric. To study finite size effects, we perform 27648 and 55296 ion simulations. To help monitor non-equilibrium effects, we calculate diffusion constants $D_i$. For the carbon-oxygen system we find that $D_O$ for oxygen ions in the solid is much smaller than $D_C$ for carbon ions and that both ...

  7. Rekonstrukcija i izrada 3D modela dvo-osne konvencionalne tokarilice Hobbymat MD65

    OpenAIRE

    Hršak, Božidar; Pavlic, Tomislav; Radić, Antonio

    2014-01-01

    Prikazan je postupak rekonstrukcije konvencionalne tokarilice Hobbymat MD65 u CNC (Computer Numerical Control) stroj s dvije simultane osi ugradnjom koračnih motora tipa NEMA 23 i upravljanih PC programskim sustavom Mach3-Lathe. 3D model je izrađen u programskom alatu Solid Edge ST4 – Ordered Technology, a fotorealistički prikaz modela u programskom modulu ERA (ExplodeRenderAnimate). Na temelju dokumentacije o montaži i održavanju i mjernih skica izrađena je kompletna 2D tehnička dokumentacij...

  8. Neutron emission as a function of fragment energy in the spontaneous fission of 260Md

    International Nuclear Information System (INIS)

    The authors have made the first measurement of the number of neutrons emitted in the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of 254Es, they produced 28-d 260Md, which was neutron-counted in a 1-m-diam spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58 ± 0.11, substantially less than for other actinides. A direct correlation of neutron multiplicity with fragment excitation energy is clearly demonstrated

  9. SN 2009md: Another faint supernova from a low mass progenitor

    OpenAIRE

    Fraser, M; Ergon, M.; Eldridge, J. J.; Valenti, S.; Pastorello, A.; Sollerman, J; Smartt, S. J.; Agnoletto, I.; Arcavi, I.; Benetti, S.; Botticella, M. -T.; Bufano, F.; Campillay, A.; Crockett, R. M.; Gal-Yam, A.

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival \\emph{Hubble Space Telescope} data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/L$_{\\odot}$ $\\sim4.54\\pm0.19$ dex. Using the stellar evolution code STARS, we find this to be consistent with a ...

  10. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    OpenAIRE

    R.V. Oliveira; P.C.C. Campos; P.A.S. Mourão

    2011-01-01

    In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil...

  11. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    OpenAIRE

    R.V. Oliveira; P.C.C. Campos; P.A.S. Mourão

    2011-01-01

    In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A no...

  12. Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

    Science.gov (United States)

    Dhindsa, Gurpreet K.

    Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

  13. A Conversation with David Bates, MD, MSc, Chairman of the American Medical Informatics Association

    OpenAIRE

    Raymond, Brian

    2008-01-01

    A world-renowned physician-researcher, David Bates, MD, MSc, is Chief of the Division of General Medicine at the Brigham and Women's Hospital in Boston, MA, and a Professor at Harvard Medical School and the Harvard School of Public Health, where he is codirector of the Program in Clinical Effectiveness. He is the Medical Director of Clinical and Quality Analysis, Information Systems at Partners HealthCare System, Inc. He is also the former Chair of the National Alliance for Primary Care Infor...

  14. Mark Plotkin, PhD: in search of plants that heal. Interview by Bonnie Horrigan.

    Science.gov (United States)

    Plotkin, M

    1996-03-01

    Ethnobotantist Mark Plotkin, PhD, spent much of the last decade in the rain forests of South America, learning about curative plants and medical practices from the tribal shamans. Through his work with indigenous people in Brazil, French Guiana, Suriname, and Venezuela, he has categorized more than 300 shaman plant cures. Plotkin studied ethnobotany at Harvard, Yale, and Tufts, and is the first botanist to receive the San Diego Zoological Society's Conservation Medal. He previously served as director of plant conservation at the World Wildlife Fund, the world's largest conservation organization, and as vice president of Conservation International. Founder of the "Shaman's Apprentice Program," which encourages younger tribal members to apprentice under the aging shamans, Plotkin currently devotes his time to curative plant research, consultation, lecturing, writing, and fund raising for his new organization, the Conservation and Ethnobiology Alliance. He has published numerous scientific articles and is the author of the popular book, Tales of a Shaman's Apprentice. PMID:8795891

  15. Frizzled to finance: one PhD's path from a Drosophila lab to Wall Street.

    Science.gov (United States)

    Taylor, Job

    2016-06-01

    An equity research analyst's job is to determine whether the price of a stock is likely to go up or down. For science-based businesses, particularly biotechnology companies, a PhD in the life sciences can be very helpful in making this determination. I transitioned from a postdoc position to working in equity research. Here I present information on how I made the transition, an overview of the day-to-day activities of an analyst, and thoughts on how to prepare to look for a job in finance. There are significant positives to working on Wall Street, including exposure to cutting-edge clinical/translational research, access to some of the best scientists in the world, a dynamic work environment, and compensation that generally exceeds academic salaries. This comes at the cost of some independence and the satisfaction of being able to call oneself a scientist. PMID:27235096

  16. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R

    Directory of Open Access Journals (Sweden)

    John Grable

    2014-08-01

    Full Text Available John E. Grable, Ph.D., CFP(R teaches and conducts research in the Certified Financial Planner(TM Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research interests include financial risk-tolerance assessment, psychophysiological economics, and financial planning help-seeking behavior. Dr. Grable has published nearly 100 peer-reviewed papers, co-authored two financial planning textbooks, and co-edited a financial planning and counseling scales book. He currently writes a quarterly column for the Journal of Financial Service Professionals, serves as academic consultant to the Journal of Financial Planning, and chair the CFP Board Council on Education.

  17. Wrapping it up in a person: Examining employment and earnings outcomes for Ph.D. recipients.

    Science.gov (United States)

    Zolas, Nikolas; Goldschlag, Nathan; Jarmin, Ron; Stephan, Paula; Smith, Jason Owen-; Rosen, Rebecca F; Allen, Barbara McFadden; Weinberg, Bruce A; Lane, Julia I

    2015-12-11

    In evaluating research investments, it is important to establish whether the expertise gained by researchers in conducting their projects propagates into the broader economy. For eight universities, it was possible to combine data from the UMETRICS project, which provided administrative records on graduate students supported by funded research, with data from the U.S. Census Bureau. The analysis covers 2010-2012 earnings and placement outcomes of people receiving doctorates in 2009-2011. Almost 40% of supported doctorate recipients, both federally and nonfederally funded, entered industry and, when they did, they disproportionately got jobs at large and high-wage establishments in high-tech and professional service industries. Although Ph.D. recipients spread nationally, there was also geographic clustering in employment near the universities that trained and employed the researchers. We also show large differences across fields in placement outcomes. PMID:26659054

  18. Preliminary and Partial Inventory of PhD Theses and their Authors

    Directory of Open Access Journals (Sweden)

    Coordinators TRI's National Network

    2013-04-01

    Full Text Available The mission statement of the Terrorism Research Initiative (TRI is “Enhancing Security through Collaborative Research”. TRI has been encouraging young scholars who are in the process of writing their PhD theses to link up and collaborate with fellow researchers in their own countries. As a result, post-graduate students have begun to interact for their own mutual benefit and for the good of the wider research community. In fact, in a number of cases several senior, post-doctoral scholars have also joined TRI’s national networks of those studying terrorism, political violence and armed conflict, and ways to prevent and counter such threats to human security. 

  19. Researcher Profile: An Interview with Sonya Britt, Ph.D., CFP, AFC

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2013-08-01

    Full Text Available Sonya Britt, Ph.D., CFP, AFC graduated from Texas Tech University in 2010 with a doctorate in Personal Financial Planning. Her first two degrees are from Kansas State University in Personal Financial Planning (B.S. and Marriage and Family Therapy (M.S.. and she was the founding president of the Financial Therapy Association and recently retired from the board as past-president. She currently serves on the board of the American Council on Consumer Interests association. Sonya is an associate editor for the Journal of Family and Economic Issues and on the editorial board of the Journal of Financial Therapy and on the international scientific board of the Italian Journal of Sociology of Education.

  20. An Impact Analysis of Regional Industry--University Interactions: The Case of Industrial PhD Schools

    Science.gov (United States)

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry--university…

  1. Assessment Procedures of Norwegian PhD Theses as Viewed by Examiners from the USA, the UK and Sweden

    Science.gov (United States)

    Kyvik, Svein

    2014-01-01

    This article focuses on the assessment procedures of Norwegian PhD theses as viewed by external members of evaluation committees from three countries with different examination systems; the USA, the UK and Sweden. Their viewpoints give useful information not only on the pros and cons with the Norwegian system, but also on the strengths and…

  2. On the Importance of PhD Institute in Establishing a Long-Term Research Career in Astronomy

    CERN Document Server

    Gibson, B K; Vassiliadis, E; Sevenster, M N; Jones, D H; Thornberry, R K; Gibson, Brad K.; Buxton, Michelle; Vassiliadis, Emanuel; Sevenster, Maartje N.; Thornberry, Rebecca K.

    1999-01-01

    We have examined the success rates of 19 American, Canadian, Australian, and Dutch graduate programs in producing astronomers. A 20-year baseline was considered (1975-1994), incorporating 897 PhD recipients. The major conclusion from our study is that the fraction of PhD graduates still involved in astronomical research is surprisingly insensitive to the institutional source of one's PhD. With few exception, 55-75% of graduates, regardless of PhD source, remain active in the astronomical research community. While it remains true that graduates of so-called ``prestigious'' programs preferentially populate the same, it is also clear that an abundance of opportunities exist at smaller ``non-prestigious'' institutions, liberal arts colleges, government, and industry. The latter, of course, generally carry enhanced administrative and/or teaching duties, but, on the other hand, do not entirely preclude a role in the research community. A Kepler-Meier survival analysis of two disparate institutes demonstrates that `...

  3. Phd dissertation on: Effects of an expressive writing intervention in a nationwide sample of breast cancer patients

    DEFF Research Database (Denmark)

    Jensen-Johansen, Mikael Birkelund

    2010-01-01

    This PhD thesis consists of four original papers, including a systematic review and meta-analysis, a pilot-study, and the to date largest nationwide randomized controlled trial examining the effects of expressive writing intervention (EWI) on psychological adjustment, somatic symptoms, and health...

  4. Trends in Ph.D. Productivity and Diversity in Top-50 U.S. Chemistry Departments: An Institutional Analysis

    Science.gov (United States)

    Laursen, Sandra L.; Weston, Timothy J.

    2014-01-01

    The education of doctoral chemists contributes to the chemical research enterprise and thus to innovation as an engine of the economy. This quantitative analysis describes trends in the production and diversity of chemistry Ph.D. degrees in the top-50 U.S. Ph.D.-granting departments in the past two decades. Time series data for individual…

  5. Learning to Write a Research Article: Ph.D. Students' Transitions toward Disciplinary Writing Regulation

    Science.gov (United States)

    Castello, Montserrat; Inesta, Anna; Corcelles, Mariona

    2013-01-01

    This paper presents a study designed from a socially situated and activity theory perspective aimed at gaining a deeper understanding of how Ph.D. students regulate their academic writing activity. Writing regulation is a complex activity of a highly situated and social nature, involving cyclical thought-action-emotion dynamics and the…

  6. Quality Indicators and Expected Outcomes for Social Work PhD Programs: Perceptions of Social Work Students, Faculty, and Administrators

    Science.gov (United States)

    Petr, Christopher G.; Harrington, Donna; Kim, Kyeongmo; Black, Beverly; Cunningham-Williams, Renee M.; Bentley, Kia J.

    2015-01-01

    This article presents and discusses the results of a national survey of social work PhD students, faculty, and administrators (n = 416), conducted by the Group for the Advancement of Doctoral Education in Social Work (GADE), in December 2012. The survey was undertaken to inform the updating of GADE's 2003 "Guidelines for Quality in Social…

  7. PhD Students' Experiences of Thesis Supervision in Malaysia: Managing Relationships in the Midst of Institutional Change

    Science.gov (United States)

    Krauss, Steven Eric; Ismail, Ismi Arif

    2010-01-01

    Despite the plethora of studies that have been conducted on PhD supervision, little qualitative investigation has been conducted with a diverse, non-Western sample of doctoral students in an attempt to understand how the supervisory relationship is experienced. In response, eighteen students from diverse, non-Western backgrounds studying at one…

  8. A Study on Changes of Supervision Model in Universities and Fostering Creative PhD Students in China

    DEFF Research Database (Denmark)

    Luo, Lingling; Zhou, Chunfang; Zhang, Song

    2015-01-01

    This paper aims to explore the changes of supervision model in higher education in relation to fostering creative Ph.D. students in China. The changes are being made from the traditional Apprentice Master Model (AMM) to the modern Collaborative Cohort Model (CCM). According to the results of the...... also explores the reason of why the mechanism failed to play fully....

  9. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Shanshuang, E-mail: shiss@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Song, Yuntao; Yang, Qingxi; Xu, Hao; Wang, Zhongwei [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Liu, Wandong; Li, Hong; Wan, Shude; Ding, Weixing [School of Physical Sciences, University of Science and Technology of China, Hefei 230031 (China); Luo, Zhiren; Zheng, Jinxing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2013-12-15

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C.

  10. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    International Nuclear Information System (INIS)

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C

  11. Portuguese validation of the Symptom Inventory of the M.D. Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Adriane Cristina Bernat Kolankiewicz

    2014-12-01

    Full Text Available Objective To analyze the reliability and validity of the psychometric properties of the Brazilian version of the instrument for symptom assessment, titled MD Anderson Symptom Inventory - core. Method A cross-sectional study with 268 cancer patients in outpatient treatment, in the municipality of Ijuí, state of Rio Grande do Sul, Brazil. Results The Cronbach’s alpha for the MDASI general, symptoms and interferences was respectively (0.857, (0.784 and (0.794. The factor analysis showed adequacy of the data (0.792. In total, were identified four factors of the principal components related to the symptoms. Factor I: sleep problems, distress (upset, difficulties in remembering things and sadness. Factor II: dizziness, nausea, lack of appetite and vomiting. Factor III: drowsiness, dry mouth, numbness and tingling. Factor IV: pain, fatigue and shortness of breath. A single factor was revealed in the component of interferences with life (0.780, with prevalence of activity in general (59.7%, work (54.9% and walking (49.3%. Conclusion The Brazilian version of the MD Anderson Symptom Inventory - core showed adequate psychometric properties in the studied population.

  12. Full-Scale Crash Test of a MD-500 Helicopter with Deployable Energy Absorbers

    Science.gov (United States)

    Kellas, Sotiris; Jackson, Karen E.; Littell, Justin D.

    2010-01-01

    A new externally deployable energy absorbing system was demonstrated during a full-scale crash test of an MD-500 helicopter. The deployable system is a honeycomb structure and utilizes composite materials in its construction. A set of two Deployable Energy Absorbers (DEAs) were fitted on the MD-500 helicopter for the full-scale crash demonstration. Four anthropomorphic dummy occupants were also used to assess human survivability. A demonstration test was performed at NASA Langley's Landing and Impact Research Facility (LandIR). The test involved impacting the helicopter on a concrete surface with combined forward and vertical velocity components of 40-ft/s and 26-ft/s, respectively. The objectives of the test were to evaluate the performance of the DEA concept under realistic crash conditions and to generate test data for validation of dynamic finite element simulations. Descriptions of this test as well as other component and full-scale tests leading to the helicopter test are discussed. Acceleration data from the anthropomorphic dummies showed that dynamic loads were successfully attenuated to within non-injurious levels. Moreover, the airframe itself survived the relatively severe impact and was retested to provide baseline data for comparison for cases with and without DEAs.

  13. SN 2009md: Another faint supernova from a low mass progenitor

    CERN Document Server

    Fraser, M; Eldridge, J J; Valenti, S; Pastorello, A; Sollerman, J; Smartt, S J; Agnoletto, I; Arcavi, I; Benetti, S; Botticella, M -T; Bufano, F; Campillay, A; Crockett, R M; Gal-Yam, A; Kankare, E; Leloudas, G; Maguire, K; Mattila, S; Maund, J R; Salgado, F; Stephens, A; Taubenberger, S; Turatto, M

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival HST data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/\\lsun $\\sim4.3\\pm0.2$ dex. Using the stellar evolution code STARS, we find this to be consistent with a red supergiant progenitor with $M = 7_{-1}^{+5}$ \\msun. The photometric and spectroscopic evolution of SN 2009md is similar to that of the class of sub-luminous Type IIP SNe. We estimate the mass of $^{56}$Ni ejected in the explosion to be $(5.4\\pm1.3) \\times 10^{-3}$ \\msun\\ from the luminosity on the radioactive tail, which is in agreement with the low $^{56}$Ni masses estimated for other sub-luminous Type IIP SNe. Simple modeling of the SN is presented, where we include a constraint on the radius from progenitor observations. Using this modeling we find...

  14. Numerical simulations of magnetic materials with MD-GRAPE: curvature induced anisotropy

    International Nuclear Information System (INIS)

    The time development of an array of magnetic dipoles representing the internal magnetization of a thin film is calculated using a hardware accelerator, MD-GRAPE, for the determination of the magnetic vector potential. The results for single-layer arrays of dipoles are compared with the analogous results obtained from an FFT method and found to be in reasonable agreement. Three-dimensional MD-GRAPE simulations with sinusoidal deformations illustrate the utility of the hardware accelerator in cases that cannot be solved easily with FFT methods. The deformations give the internal field an asymmetry with components parallel to the wave crest, leading to significant changes in the critical external fields required for switching. These changes occur even for small wave amplitudes, comparable to or less than the layer thickness. Layer curvature affects the astroid pattern of critical field strengths by shifting the threshold to lower absolute values of the hard axis field when the curvature is in the easy axis direction, and lower absolute values of the easy axis field when the curvature is in the hard axis direction. This effect of curvature differs from orange peel coupling between two layers because here there is only one layer, and because orange peel coupling shifts the whole astroid pattern as a result of an effective field bias, whereas here the pattern shape is changed without any centroid shift

  15. Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques

    Directory of Open Access Journals (Sweden)

    Carla Isernia

    2013-09-01

    Full Text Available Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such regions, including the description of their structural propensities, number of conformations and relative populations can provide useful insights. Prion diseases result from the conversion of a normal glycoprotein into a misfolded pathogenic isoform. The structures of mammal and chicken prion proteins show a similar fold with a globular domain and a flexible N-terminal portion that contains different repeated regions: octarepeats (PHGGGWGQ in mammals and hexarepeats (PHNPGY in chickens. The higher number of prolines in the hexarepeat region suggests that this region may retain a significant amount of residual secondary structure. Here, we report the CD, NMR and MD characterization of a peptide (2-HexaPY composed of two hexarepeats. We combine experimental NMR data and MD to investigate at atomic level its ensemble-averaged structural properties, demonstrating how each residue of both repeats has a different quantified PPII propensity that shows a periodicity along the sequence. This feature explains the absence of cooperativity to stabilize a PPII conformation. Nonetheless, such residual structure can play a role in nucleating local structural transitions as well as modulating intra-molecular or inter-molecular interactions.

  16. The embedded atom model and large-scale MD simulation of tin under shock loading

    International Nuclear Information System (INIS)

    The goal of the work was to develop an interatomic potential, that can be used in large-scale classical MD simulations to predict tin properties near the melting curve, the melting curve itself, and the kinetics of melting and solidification when shock and ramp loading. According to phase diagram, shocked tin melts from bcc phase, and since the main objective was to investigate melting, the EAM was parameterized for bcc phase. The EAM was optimized using isothermal compression data (experimental at T=300 K and ab-initio at T=0 K for bcc, fcc, bct structures), experimental and QMD data on the Hugoniot and on the melting at elevated pressures. The Hugoniostat calculations centred at β-tin at ambient conditions showed that the calculated Hugoniot is in good agreement with experimental and QMD data above p-bct transition pressure. Calculations of overcooled liquid in pressure range corresponding to bcc phase showed crystallization into bcc phase. Since the principal Hugoniot of tin originates from the β-tin that is not described by this EAM the special initial state of bcc samples was constructed to perform large-scale MD simulations of shock loading.

  17. Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

    Science.gov (United States)

    Zhen, Yunmei; Qin, Guangrong; Luo, Cheng; Jiang, Hualiang; Yu, Kunqian; Chen, Guanghui

    2014-01-01

    Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3) mediates Ubiquitin (Ub) modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2) linked to Ub via a thioester bond to form a catalytic complex. The mechanism of Ub transfer catalyzed by RING E3 remains elusive. By employing a combined computational approach including molecular modeling, molecular dynamics (MD) simulations, and quantum mechanics/molecular mechanics (QM/MM) calculations, we characterized this catalytic mechanism in detail. The three-dimensional model of dimeric RING E3 ligase RNF4 RING, E2 ligase UbcH5A, Ub and the substrate SUMO2 shows close contact between the substrate and Ub transfer catalytic center. Deprotonation of the substrate lysine by D117 on UbcH5A occurs with almost no energy barrier as calculated by MD and QM/MM calculations. Then, the side chain of the activated lysine gets close to the thioester bond via a conformation change. The Ub transfer pathway begins with a nucleophilic addition that forms an oxyanion intermediate of a 4.23 kcal/mol energy barrier followed by nucleophilic elimination, resulting in a Ub modified substrate by a 5.65 kcal/mol energy barrier. These results provide insight into the mechanism of RING-catalyzed Ub transfer guiding the discovery of Ub system inhibitors. PMID:25003393

  18. Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

    Directory of Open Access Journals (Sweden)

    Yunmei Zhen

    Full Text Available Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3 mediates Ubiquitin (Ub modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2 linked to Ub via a thioester bond to form a catalytic complex. The mechanism of Ub transfer catalyzed by RING E3 remains elusive. By employing a combined computational approach including molecular modeling, molecular dynamics (MD simulations, and quantum mechanics/molecular mechanics (QM/MM calculations, we characterized this catalytic mechanism in detail. The three-dimensional model of dimeric RING E3 ligase RNF4 RING, E2 ligase UbcH5A, Ub and the substrate SUMO2 shows close contact between the substrate and Ub transfer catalytic center. Deprotonation of the substrate lysine by D117 on UbcH5A occurs with almost no energy barrier as calculated by MD and QM/MM calculations. Then, the side chain of the activated lysine gets close to the thioester bond via a conformation change. The Ub transfer pathway begins with a nucleophilic addition that forms an oxyanion intermediate of a 4.23 kcal/mol energy barrier followed by nucleophilic elimination, resulting in a Ub modified substrate by a 5.65 kcal/mol energy barrier. These results provide insight into the mechanism of RING-catalyzed Ub transfer guiding the discovery of Ub system inhibitors.

  19. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    Directory of Open Access Journals (Sweden)

    R.V. Oliveira

    2011-11-01

    Full Text Available In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A noteworthy absence of interest in carrying out clinical research limits the ability of young Brazilian physicians to solve biomedical problems. To understand the students’ views of science, we used qualitative and quantitative triangulation methods, as well as participant observation to evaluate the students’ concepts of science and common sense. Subjective aspects were clearly less evident in their concepts of science. There was a strong concern about "methodology", "truth" and "usefulness". "Intuition", "creativity" and "curiosity" were the least mentioned thematic categories. Students recognized the value of intuition when it appeared as an explicit option but they did not refer to it spontaneously. Common sense was associated with "consensus", "opinion" and ideas that "require scientific validation". Such observations indicate that MD-PhD students share with their senior academic colleagues the same reluctance to consider common sense as a valid adjunct for the solution of scientific problems. Overcoming this difficulty may be an important step toward stimulating the interest of physicians in pursuing experimental research.

  20. MS PHD'S: Bridging the Gap of Academic and Career Success Through Educational and Professional Development for Minorities

    Science.gov (United States)

    Brown, D.; Vargas, W.; Padilla, E.; Strickland, J.; Echols, E.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.; Ricciardi, L.; Johnson, A.; Braxton, L.

    2011-12-01

    Historically, there has been a lack of ethnic and gender diversity in the geo-sciences. The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Professional Development Program provides a bridge to young scientists of diverse backgrounds who in turn will impact many. In a process of 3 phases, the program introduces the students to the scientific community through participation in professional and society meetings and networking with scientists and personnel within federal agencies, academic institutions and STEM-based industries. The program builds confidence, offers role models for professional development and provides students support during their education. Upon completion, students achieve a high level of self-actualization and self-esteem combined with individual growth. They become part of a community that continuously provides support and security to each other. This support is tangible through the mentor/mentee relationships which will help with individual growth throughout the mentoring cycle. Having role models and familiar faces to whom mentees can relate to will encourage our students to succeed in the STEM's field. To date, 159 students have participated in the program: 26 have successfully completed their PhD and 56 are currently enrolled in the PhD programs nationwide. The MS PHD'S Program creates a forum of diverse peoples by diverse peoples with diverse interest and strength, where the ongoing goal is to continually raise the bar for each individual. MS PHD'S establishes a nurturing goal-oriented environment for the geo scientist of the future who in turn will make profound contributions on a local, national and global scale. To conclude, MSPHD'S not only bridges the gap of unrepresented minorities in STEM careers, but also generates educational approaches to make the earth system sciences available to more, impacting all.

  1. 基于JAVA技术的MD5加密算法的设计与实现%Design and Implementation of MD5 Algorithm Based on JAVA Technology

    Institute of Scientific and Technical Information of China (English)

    张浩华; 齐维毅; 赵子夫; 李瑶; 潘庆超

    2009-01-01

    详细描述了在数字签名、电子商务、信息加密领域中广泛应用的MD5加密算法,并针对其高效、跨平台使用,提出利用JSP与JavaBean相结合的技术方法实现MD5加密算法.该方法采用Java语言实现MD5算法,并利用JavaBean组件进行封装,通过JSP技术进行相应页面的动态展现,既简化JSP网页结构体现了Java体系的技术优势,又保证了应用系统的安全性、跨平台性和提高系统的执行效率.

  2. 一种基于MD5的近似图像检测算法研究%Research of similar images detection algorithm based on MD5

    Institute of Scientific and Technical Information of China (English)

    叶志伟; 夏彬; 王大震; 张彦超

    2010-01-01

    在WWW图像搜索引擎中,如何快速而准确地检测出近似或重复图像已经成为亟待解决的问题,提出一种基于MD5的近似图像检测算法.该算法选取图像分块灰度均值为特征,经过拉普拉斯特征值降维,矢量量化后,图像特征被转换为MD5值,然后根据生成的MD5值进行近似或重复图像检测.实验结果表明该算法是有效的.

  3. 基于NetMagic平台的MD5算法硬件加速模型%Hardware acceleration model of MD5 algorithm based on NetMagic platform

    Institute of Scientific and Technical Information of China (English)

    孟祥扬; 林琦

    2015-01-01

    针对MD5软件实现方法存在占用资源大、安全性差等缺点,提出了基于NetMagic平台的MD5硬件加速模型设计方案,并基于ModelSim和NetMagic平台对提出的非流水线与流水线硬件加速模型进行验证、分析.相比非流水线硬件加速模型,流水线硬件加速模型能提高MD5运算效率5倍,可用于网络处理器等硬件加密引擎,有效提高网络处理器等硬件设备的安全性和处理效率.

  4. Encrypt the User Password with the MD5 Algorithm in JAVA WEB System%JAVA WEB系统用MD5算法加密用户口令

    Institute of Scientific and Technical Information of China (English)

    李茂春; 王和顺

    2010-01-01

    在网络传输中,我们要确保一些敏感的数据在传输的过程中不会被篡改、截取,这就需要用加密算法对传输的信息进行加密.MD5是一种单向加密算法,其加密后的数据难以解密,所以广泛应用在各大型网站以及管理系统中用来保护用户口令安全.文章介绍了MD5加密算法的工作原理,并以实际应用为例介绍了JAVA WEB应用中的MD5加密算法.

  5. 基于MD5算法的身份鉴别技术的研究与实现%Study and Realization of Authentication Technique Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张建伟; 李鑫; 张梅峰

    2003-01-01

    MD5报文摘要算法是一种应用广泛的身份认证算法,该文首先对数据加密技术进行了简要的概述.在剖析MD5算法工作原理的基础上,结合DES加密算法,采用加入时间戳、绑定IP地址的基于MD5文摘算法的一次一密方法,给出一个对访问用户口令加密的安全实现,并成功地应用于某高校"艺术类远程招生与考试管理系统".

  6. The Design of Identity Authentication Scheme of Network Examination Based on MD5 and RSA Algorithm%基于MD5和 RSA 算法的网络考试身份认证方案设计

    Institute of Scientific and Technical Information of China (English)

    许永达

    2013-01-01

      Establishing a good identity authentication system is one of the key steps to realize the network examination security ,and tradi-tional identity authentication methods like “username + password” have a big security risk .So an identity authentication scheme based on MD5 and RSA Algorithm is proposed ,which uses the MD5 algorithm to improve the“username + password” authentication method ,and then uses the digital signature based on MD5 and RSA algorithm to further verify the user’s identity .This scheme can effectively confirm us-er identity ,and greatly enhance the safety performance of the examination system .%  建立完善的身份认证系统是实现网络考试安全的关键步骤之一,而“用户名+密码”等传统身份认证方式存在较大的安全隐患。文章提出了一种基于MD5和RSA算法的身份认证方案,先利用MD5算法来改进“用户名+密码”认证方法,再借助MD5和RSA算法实现的数字签名来进一步验证用户的身份。该方案可以高效确认用户身份,极大地增强了考试系统的安全性能。

  7. 八棱海棠MdPPO2B基因的表达及功能分析%Expression and Functional Analysis ofMdPPO2BfromMalus robusta

    Institute of Scientific and Technical Information of China (English)

    沈雪芳; 韩晴; 高建杰; 彭日荷; 王波; 高志红; 姚泉洪; 章镇

    2015-01-01

    多酚氧化酶(PPO)是一种含多个铜离子的氧化还原酶,可催化酚类物质氧化为醌类物质。我们从八棱海棠中克隆到一个PPO的同源基因MdPPO2B,构建该基因酵母分泌表达载体并转化到毕赤酵母GS115中。SDS-PAGE电泳结果显示,表达蛋白MdPPO2B的分子量约为66.4 kDa。以邻苯二酚作为底物,该酶的最适pH和温度分别为6.5和40℃。除Cu2+、Na+、Mg2+和Li+外,4 mmol·L-1的Fe3+、Zn2+、Mn2+对酶活力表现出较强的抑制作用。在最适条件下,当苯酚浓度达600μmol·L-1时,反应4 h, MdPPO2B表达菌株可降解80%的苯酚。表明该基因在工业污水处理中具有广阔的应用潜力。%Polyphenol oxidase (PPO) is one of oxidoreductase enzymes, which catalyzes the phenols to diqui-nones. A putative PPO gene (MdPPO2B) wascloned fromMalus robusta and exogenously expressed inPichia pastoris GS115. SDS-PAGE showed thatMdPPO2B has a molecular mass of approximately 66.4 kDa. With catechol as substrate, it was showed that the optimum pH and temperature forMdPPO2B was 6.5 and 40℃, respectively. Except for Cu2+, Na+, Mg2+ and Li+, Fe3+, Zn2+ and Mn2+ inhibited the enzyme activity at a concen-tration of 4 mmol·L-1. TheMdPPO2B degraded 80% phenol after incubated for 4 h under the optimum condi-tion. In short, our original research onMdPPO2B may provide reference for the application of microorganism in industrial wastewater.

  8. MD5算法及其在电视节目技术质量控制中的应用%The Application of MD5 Algorithm in TV Program Technique Quality Control System

    Institute of Scientific and Technical Information of China (English)

    刘元春

    2010-01-01

    MD5算法是一种广泛应用的典型Hash加密算法,在详细剖析MD5算法的基础上,对其基于文件电视节目技术质量控制系统中的应用,如何解决普遍存在的文件完整性检测、密码保护、越权访问、文件重复性校验、责任追溯等安全问题进行了探索.

  9. 一种基于MD5硬件Key的票据号产生方法%A method of Produced Notes Number With MD5 Algorithm and IKey

    Institute of Scientific and Technical Information of China (English)

    谢琦; 杨文娜

    2009-01-01

    文章讨论了一种基于加密处理器的商业票据产生方法,介绍了采用多个母密钥片断产生MD5密钥的算法,以及密钥在加密处理器中的存储和管理方式,并给出了基于MD5算法产生票据号的实现方法和试验结果.

  10. MD Simulations on a Flexible Chain Polyethylene: the Effect of the Electrostatic Forces in the Density-Temperature Behavior

    CERN Document Server

    Kretov, D A

    2004-01-01

    Molecular Dynamics (MD) simulations have been performed on the parallel-vector and special-purposes MD machines to study the dynamical behaviors of a flexible polyethylene (PE) chain subjected to various heating conditions. Both the effect of the short-range and electrostatic interactions on the dynamics of the PE system were estimated and compared. For this purpose three different simulations were performed regarding on the following regimes: fast, moderate and slow heating processes. The peculiarities of the main thermodynamic quantities of the system were estimated in detail and compared for all three processes. Molecular mechanical and MD calculations on the PE system were performed using the optimized version of the DL_POLY code, adapted for the vector- and special-purpose MDGRAPE-2 machines.

  11. 25 ns studies in the LHC – MD held on 14/10/2011

    CERN Document Server

    Arduini, G; Biancacci, N; Buffat, X; Dominguez, O; Iadarola, G; Métral, E; Rumolo, G; Salvant, B; Zannini, C; Roncarolo, F; Esteban Muller, JF; Höfle, W; Shaposhnikova, E; Valuch, D; Cettour-Cave, S; Kain, V; Redaelli, S; Barnes, M; Bartmann, W; Bracco, C; Goddard, B; Claudet, S; Tavian, L; Baglin, V; Bregliozzi, G; Kersevan, R; Lanza, G

    2012-01-01

    The machine development session (12 hours) was devoted to the injection of several trains of 72 bunches with nominal bunch population and 25 ns bunch spacing with the aim of injecting up to 1000 bunches/beam. This was the third of a series MD periods (in total 72 hours were requested at the beginning of the year) dedicated to electron cloud and scrubbing studies with 25 ns beams. The first one (8 hours on 26/08/2011) was lost due to a cryogenics problem. The second (12 hours) took place on 6/10/2011 and was mostly dedicated to the setting-up of the injection and of the transverse damper.

  12. MD simulation and cluster analyses of the gas permeability of parylene AF4 membranes

    Science.gov (United States)

    Bian, Liang; Shu, Yuan-jie; Song, Mian-xin; Dong, Fa-qin; Li, Wei-min; Xu, Jinbao; Zhang, Xiao-yan

    2016-02-01

    In poly-p-xylylene (parylene) AF4 membranes, amorphous and crystalline areas were constructed by a novel computational technique: a combination of NVT + NPT-molecular dynamics (MD) and "gradually reduce the size" (GRS) methods. The corresponding free volume was determined via the homology cluster method. Crystalline parylene AF4 membranes were found to provide less free volume for the adsorption and transfer of gases than amorphous parylene AF4. The permeability results showed that amorphous and crystalline parylene AF4 membranes have different permeation properties, and the corresponding permeability coefficients approach those observed experimentally. This work determined the behaviours and directions of diffusing gases via a cluster analysis technique. Gas diffusion occurs only along the y-axis in the crystalline area and randomly in the amorphous area. The relative permeability was close to the experimental value.

  13. pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins.

    Directory of Open Access Journals (Sweden)

    Priyanka Prakash

    2015-10-01

    Full Text Available Probe-based or mixed solvent molecular dynamics simulation is a useful approach for the identification and characterization of druggable sites in drug targets. However, thus far the method has been applied only to soluble proteins. A major reason for this is the potential effect of the probe molecules on membrane structure. We have developed a technique to overcome this limitation that entails modification of force field parameters to reduce a few pairwise non-bonded interactions between selected atoms of the probe molecules and bilayer lipids. We used the resulting technique, termed pMD-membrane, to identify allosteric ligand binding sites on the G12D and G13D oncogenic mutants of the K-Ras protein bound to a negatively charged lipid bilayer. In addition, we show that differences in probe occupancy can be used to quantify changes in the accessibility of druggable sites due to conformational changes induced by membrane binding or mutation.

  14. An novel architecture for information hiding using HMAC-MD5

    Directory of Open Access Journals (Sweden)

    Agilandeeswari Loganathan

    2013-03-01

    Full Text Available Communication in digital form has become the part of day today’s lifestyle, in certain moment communication is made secret to avoid others from knowing the information. By providing security to the sensitive data it is ensured that the user’s data is protected from viewing and accessing by others. In the current discussion about data security, Steganographic algorithm using two mediums has been discussed that involves image based encryption and converting to word file. The stage involving image based encryption uses HMAC-MD5 algorithm along with LSB steganography. LSB technique scatters the secret data which have to be protected over the entire image. Convert the embedded image in word file, so that the secret message is made unavailable to others who try to obtain the file. This method provides greater payload capacity along with higher image fidelity and thus make the proposed system is more robust against attacks. 

  15. Static and dynamic properties of confined, cold ion plasmas: MD (molecular dynamics) simulations

    Energy Technology Data Exchange (ETDEWEB)

    Schiffer, J.P.

    1989-01-01

    Some four years ago it was suggested that in the new generation of heavy ion accelerator storage rings for multiply charged ions, being planned in Europe, one may well attain internal temperatures that would correspond to very cold plasmas. Since that time, the techniques of electron or laser cooling of such beams has evolved and it may well be possible to reach temperatures corresponding to a plasma coupling parameter {Gamma} >> 100. I was fortunate to have had an opportunity to collaborate during 1986-87 with my former colleague Aneesur Rahman, of Molecular Dynamics fame, and we adapted the MD method to the calculation of the properties of cold confined plasmas. After Rahman's premature death two years ago I have continued the exploration of these systems and would like to summarize the results here. 9 refs., 10 figs.

  16. Extension of the M-D model for treating stress drops in salt

    Energy Technology Data Exchange (ETDEWEB)

    Munson, D.E. [Sandia National Labs., Albuquerque, NM (United States); DeVries, K.L.; Fossum, A.F.; Callahan, G.D. [RE/SPEC Inc., Rapid City, SD (US)

    1993-07-01

    Development of the multimechanism deformation (M-D) constitutive model for steady state creep, which incorporates irreversible workhardening and recovery transient strains, was motivated by the need to predict very long term closures in underground rooms for radioactive waste repositories in salt. The multimechanism deformation model for the creep deformation of salt is extended to treat the response of salt to imposed stress drops. Stress drop tests produce a very distinctive behavior where both reversible elastic strain and reversible time dependent strain occur. These transient strains are negative compared to the positive transient strains produced by the normal creep workhardening and recovery processes. A simple micromechanical evolutionary process is defined to account for the accumulation of these reversible strains, and their subsequent release with decreases in stress. A number of experimental stress drop tests for various stress drop magnitudes and temperatures are adequately simulated with the model.

  17. Extension of the M-D model for treating stress drops in salt

    International Nuclear Information System (INIS)

    Development of the multimechanism deformation (M-D) constitutive model for steady state creep, which incorporates irreversible workhardening and recovery transient strains, was motivated by the need to predict very long term closures in underground rooms for radioactive waste repositories in salt. The multimechanism deformation model for the creep deformation of salt is extended to treat the response of salt to imposed stress drops. Stress drop tests produce a very distinctive behavior where both reversible elastic strain and reversible time dependent strain occur. These transient strains are negative compared to the positive transient strains produced by the normal creep workhardening and recovery processes. A simple micromechanical evolutionary process is defined to account for the accumulation of these reversible strains, and their subsequent release with decreases in stress. A number of experimental stress drop tests for various stress drop magnitudes and temperatures are adequately simulated with the model

  18. Diffusion of hydrocarbon in zeolite and effect due to pore topology: Neutron scattering and MD simulation studies

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, S.; Sharma, V.K.; Chaplot, S.L.; Mukhopadhyay, R., E-mail: mukhop@barc.gov.in

    2014-02-17

    Highlights: • Dynamical landscape of propylene adsorbed in two different zeolites is obtained. • MD simulation indicated three different time scales for the translational motion. • Neutron scattering data correspond to one of the three different time scales. • Faster rotational motion observed in a wider energy window neutron spectrometer. • Propylene found to be in preferred orientation in ZSM5 but not in Na–Y zeolite. - Abstract: Here we report detailed dynamical landscape of propylene adsorbed in ZSM5 and Na–Y zeolites as studied by neutron scattering and molecular dynamics (MD) simulation. Separation of propylene molecule from propane in the petrochemical industry is an important issue because it is one of the most demanding energetic separation processes due to their very close relative volatilities and molecular sizes. Aim here is to investigate the correlation of the host topology towards the dynamics of guest molecules. ZSM5 zeolite is typified by a network of intersecting channels while Na–Y has a network of spherical supercages interconnected by windows. Both neutron scattering and MD simulation studies indicated that translational diffusion of propylene is more restricted in ZSM5 compared to Na–Y zeolite. Fully atomistic MD simulation studies showed that the translation involves three different time scales and rotational motion of the propylene is much faster than translation. The observed dynamics in QENS spectrometer (ΔE ∼ 200 μeV) corresponds to one of the three translational components indicated in the MD simulation. The faster rotational motion is observed in a wider energy window spectrometer (ΔE ∼ 3 meV). MD simulation results also show some interesting features like, non-isotropic rotation in ZSM5 while it has been isotropic in Na–Y zeolite. It is also found that propylene molecules prefer to orient along channels of ZSM5 zeolite.

  19. Enhanced performance of PVDF nanocomposite membrane by nanofiber coating: A membrane for sustainable desalination through MD.

    Science.gov (United States)

    Efome, Johnson E; Rana, Dipak; Matsuura, Takeshi; Lan, Christopher Q

    2016-02-01

    Membrane distillation (MD) is a promising separation technique capable of being used in the desalination of marine and brackish water. Poly(vinylidene fluoride) (PVDF) flat sheet nano-composite membranes were surface modified by coating with electro-spun PVDF nano-fibres to increase the surface hydrophobicity. For this purpose, the nano-composite membrane containing 7 wt.% superhydrophobic SiO2 nano-particles, which showed the highest flux in our previous work, was first subjected to pore size augmentation by increasing the concentration of the pore forming agent (Di-ionized water). Then, the prepared flat sheet membranes were subjected to nanofibres coating by electro-spinning. The uncoated and coated composite fabricated membranes were characterized using contact angle, liquid entry pressure of water, and scanning electron microscopy. The membranes were further tested for 6 h desalination by direct contact membrane distillation (DCMD) and vacuum membrane distillation (VMD), with a 3.5 wt.% synthetic NaClaq as the feed. In DCMD the feed liquid and permeate side temperature were maintained at 27.5 °C and 15 °C, respectively. For VMD, the feed liquid temperature was 27 °C and a vacuum of 94.8 kPa was applied on the permeate side. The maximum permeate flux achieved was 3.2 kg/m(2).h for VMD and 6.5 kg/m(2).h for DCMD. The salt rejection obtained was higher than 99.98%. The coated membranes showed a more stable flux than the uncoated membranes indicating that the double layered membranes have great potential in solving the pore wetting problem in MD. PMID:26630042

  20. Mapping a candidate gene (MdMYB10 for red flesh and foliage colour in apple

    Directory of Open Access Journals (Sweden)

    Allan Andrew C

    2007-07-01

    Full Text Available Abstract Background Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS is a tool that can be used to accelerate the development of novel apple varieties such as cultivars that have fruit with anthocyanin through to the core. In addition, determining the inheritance of novel alleles, such as the one responsible for red flesh, adds to our understanding of allelic variation. Our goal was to map candidate anthocyanin biosynthetic and regulatory genes in a population segregating for the red flesh phenotypes. Results We have identified the Rni locus, a major genetic determinant of the red foliage and red colour in the core of apple fruit. In a population segregating for the red flesh and foliage phenotype we have determined the inheritance of the Rni locus and DNA polymorphisms of candidate anthocyanin biosynthetic and regulatory genes. Simple Sequence Repeats (SSRs and Single Nucleotide Polymorphisms (SNPs in the candidate genes were also located on an apple genetic map. We have shown that the MdMYB10 gene co-segregates with the Rni locus and is on Linkage Group (LG 09 of the apple genome. Conclusion We have performed candidate gene mapping in a fruit tree crop and have provided genetic evidence that red colouration in the fruit core as well as red foliage are both controlled by a single locus named Rni. We have shown that the transcription factor MdMYB10 may be the gene underlying Rni as there were no recombinants between the marker for this gene and the red phenotype in a population of 516 individuals. Associating markers derived from candidate genes with a desirable phenotypic trait has demonstrated the application of genomic tools in a breeding programme of a horticultural crop species.