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Sample records for burke md phd

  1. Book review of "The Ethics of Coercion in Mass Casualty Medicine" by Griffin Trotter MD, PhD

    Directory of Open Access Journals (Sweden)

    Singh Sonal

    2007-10-01

    Full Text Available Abstract Public health ethics is neither taught widely in medical schools or schools of public health in the US or around the world. It is not surprising that health care professionals are particularly challenged when faced with ethical questions which extend beyond safeguarding the interests of their individual patients to matters that affect overall public good. The perceived threat of terror after September 11 2007, the anthrax attacks and the Katrina debacle are recent circumstances which may result in coercion. These have piqued the interest of medical professionals and the general public on public health ethics. The Ethics of Coercion in Mass Casualty Medicine written by Griffin Trotter MD, PhD attempts to fill a timely void in this area by examining the ethics of coercion in times of public health disasters.

  2. Perspective: PhD scientists completing medical school in two years: looking at the Miami PhD-to-MD program alumni twenty years later.

    Science.gov (United States)

    Koniaris, Leonidas G; Cheung, Michael C; Garrison, Gwen; Awad, William M; Zimmers, Teresa A

    2010-04-01

    Producing and retaining physician-scientists remains a major challenge in advancing innovation, knowledge, and patient care across all medical disciplines. Various programs during medical school, including MD-PhD programs, have been instituted to address the need for continued production of physician-scientists. From 1971 through 1989, 508 students with a prior PhD in the sciences, mathematics, or engineering graduated in two years from an accelerated MD program at the University of Miami School of Medicine. The program, designed to address potential clinical physician shortages rather than physician-scientist shortages, quickly attracted many top-notch scientists to medicine. Many program graduates went to top-tier residencies, pursued research careers in academic medicine, and became academic leaders in their respective fields. A retrospective examination of graduates conducted in 2008-2009 demonstrated that approximately 59% took positions in academic university medical departments, 3% worked for governmental agencies, 5% entered industry as researchers or executives, and 33% opted for private practice. Graduates' positions included 85 full professors, 11 university directors or division heads, 14 academic chairs, 2 medical school deans, and 1 astronaut. Overall, 30% of graduates had obtained National Institutes of Health funding after completing the program. These results suggest that accelerated medical training for accomplished scientists can produce a large number of successful physician-scientists and other leaders in medicine. Furthermore, these results suggest that shortening the medical portion of combined MD-PhD programs might also be considered. PMID:20354390

  3. Teaching Burke Using Advertisements.

    Science.gov (United States)

    Larson, Charles U.

    Kenneth Burke's concepts of identification, the five terms of dramatism, and strategic uses of ambiguity can be successfully taught to undergraduates if appropriate and familiar examples are used. Print and electronic advertising offer the instructor an up-to-date, familiar, and abundant source of classroom examples. Market segmentation models…

  4. Obituary: Edward W. Burke, Jr. (1924-2011)

    Science.gov (United States)

    Bloomer, Raymond, Jr.

    2011-12-01

    Dr. Edward W. Burke Jr. passed away on June 15, 2011, after suffering a heart attack. Dr. Burke devoted his professional life to the research and teaching of physics and astronomy at King College in Bristol, Tennessee. Edward W. Burke, Jr., was born in Macon, Georgia, on September 16, 1924. He was a Navy veteran, having been commissioned as an ensign in 1944. He served in the Pacific near the end of World War II. He proceeded to complete his undergraduate degree in mathematics from Presbyterian College in 1947 and pursued the M.S. and Ph.D. in physics (1949 and 1954, respectively) at the University of Wisconsin. Under the direction of Professor Julian Mack, his thesis was titled "Isotope Shift in the Spectra of Boron." Although he did research in atomic spectra in the early part of his career, his interest in astronomy and variable stars in particular were his primary interests during his long academic career. Dr. Burke began his illustrious career at King College in 1949. He initiated the astronomy program there in 1950, included constructing a 12.5 inch Newtonian telescope, homemade as was most everything in those days. Many of his students learned about photometry at the Burke Observatory on the college campus. Burke was known for his trips to the Kitt Peak and Lowell observatories accompanied by undergraduate students on his trips, all of which were made by automobile which he preferred over flying. His initial interest in Ap stars later broadened into variable and especially eclipsing binary stars. His motivation was maintained by his desire to have his students experience basic research and to spark their interest in advanced degrees. Numerous students achieved advanced science and medical degrees because of Burke's encouragement and mentoring. In 1959, Dr. Burke was awarded a Fulbright professorship and traveled to Chile where he taught physics for a year in the Engineering School at the University of Chile in Santiago. He worked to establish a physics

  5. Interrogating Joe Burke and His Legacy: The Joseph Burke Lecture 2005

    OpenAIRE

    Jaynie Anderson

    2011-01-01

    Art history’s history in Melbourne began with the appointment of Joseph Burke (1913-1992) to the Herald Chair of Fine Arts in 1946. Burke made a number of remarkable appointments with Ursula Hoff, Franz Phillip, and Bernard Smith to create the seminal department of art history in Australia. Burke’s real field of expertise was in the English eighteenth century. Like many intellectuals of the diaspora, he transposed his scholarship to a different society. This article is based on Burke’s corres...

  6. Synecdoche against Metonymy: Burke, Freire, and Writing Instruction.

    Science.gov (United States)

    Hunter, Paul

    1990-01-01

    Argues that the metaphor of writing as a tool is still used because the ideas of Kenneth Burke have not been applied comprehensively. Argues further that Burke's "A Grammar of Motives" implies a radical change in what it means to teach students to analyze and produce texts--a change leading up to and beyond Freireian pedagogy. (RS)

  7. 77 FR 46117 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-02

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains... contact the Burke Museum. Disposition of the human remains and the associated funerary object to...

  8. 78 FR 11675 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-02-19

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains... believes itself to be culturally affiliated with the human remains may contact the Burke...

  9. 77 FR 51564 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-24

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington, has completed an... contact the Burke Museum. Repatriation of the human remains to the tribe named below may occur if...

  10. Kuidas kirjutatakse ajalugu? / Peter Burke ; interv. Marek Tamm, tlk. Ainiki Väljataga

    Index Scriptorium Estoniae

    Burke, Peter

    2007-01-01

    Renessansiajastu kultuuriloost, keelest sotsiaalajaloo uurimisobjektina ning ajalookirjutuse ajaloost ja teooriast Cambridge'i Ülikooli kultuuriajaloo emeriitprofessoti P. Burke'i teostes. Varem ilm.: Burke, Peter. Kultuuride kohtumine : esseid uuest kultuuriajaloost. Tallinn, 2006. Lk. 275-286

  11. Division, Unity, and Consciousness Raising: Burke and Ong on Technology.

    Science.gov (United States)

    Palmeri, Anthony J.

    In an effort to contribute to the dialogue on the effects of the intensification of technology upon the structure and dynamics of human communication, this paper examines the views of technology in the works of Kenneth Burke and Walter Ong. The paper argues that their theories can be compatible, that Ong's view of writing as a technology which…

  12. Burke, Nietzsche, Lacan: Three Perspectives on the Rhetoric of Order.

    Science.gov (United States)

    Thomas, Douglas

    1993-01-01

    Examines the complex relationship between rhetoric and order in the works of Kenneth Burke, Friedrich Nietzsche, and Jacques Lacan. Argues for three differing, yet complementary, views of rhetoric and order, each having a corresponding epistemology and axiology. Concludes with an analysis of the construction of order in Thomas Hobbe's "Leviathan."…

  13. "The Piety of Degradation": Kenneth Burke, the Bureau of Social Hygiene, and "Permanence and Change"

    Science.gov (United States)

    Jack, Jordynn

    2004-01-01

    Kenneth Burke's employment with the Bureau of Social Hygiene informed his rhetorical theory in the 1930s. Between 1926 and 1930, Burke researched criminology and drug addiction and ghostwrote a book for Colonel Arthur Woods, "Dangerous Drugs". An investigation of archives indicates that this research left its mark on Burke's "Permanence and…

  14. 75 FR 36671 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... the Federal Register (75 FR 5105-5106, February 1, 2010). In the Federal Register, paragraph number 7... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... funerary objects in the possession of the Thomas Burke Memorial Washington State Museum (Burke...

  15. 78 FR 64006 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-10-25

    ... were included in a Notice of Inventory Completion published in the Federal Register (78 FR 45958-45959... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum, University of Washington (Burke Museum), has completed...

  16. Traditionalism and modern subjectivity: Enlightenment and conservatism of Edmund Burke

    Directory of Open Access Journals (Sweden)

    Nikitović Aleksandar

    2003-01-01

    Full Text Available The issue of traditionalism versus modern subjectivism in the light of the conflict of Edmund Burke`s conservatism with the Enlightenment as the ideological basis of the French revolution was not discussed or studied sufficiently in our political and philosophical theory. In this paper we are reconsidering a theoretical debate between arising modern rationalism of Enlightenment and European traditionalism. The text further explains on the reasons for choosing this subject and course the research will take subsequently. An overview is provided of the most important topics as well as a preliminary conception of the problem structure in this research. Considering the importance and overwhelming influence exhorted by French revolution it is only logical that the event of such magnitude met not only with approvals but with challenges and disputes as well, and all of it contributed to the theoretical considerations of the historical sense and purpose of this event. The aim of the project is to provide explanations and evaluations of the origins Enlightenment on one hand side and theoretically reconsidered traditionalism on the other. Looking at the dawn of modern era and evaluating these events would cast sharper light on the spirit of times of this crucial moment of history, and it would provide new basis for reconsideration of the achievements and implications of the fundamental ideas of Moderna.

  17. 75 FR 36672 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Washington State Museum (Burke Museum), University of Washington, Seattle, WA. The human remains were removed... sole responsibility of the museum, institution, or Federal agency that has control of the...

  18. "More Than Lessons in How To Read": Burke, Freud, and the Resources of Symbolic Transformation.

    Science.gov (United States)

    Quandahl, Ellen

    2001-01-01

    Argues that Kenneth Burke used "The Interpretation of Dreams," as well as other works by Sigmund Freud, as a lesson on reading, taking over the central tropes of dreamwork and making them broadly dialectical rather than strictly psychoanalytic terms. Suggests that Freud's "tropology" of dreaming is crucial for reading Burke. (SG)

  19. 75 FR 434 - Notice of Intent to Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Science.gov (United States)

    2010-01-05

    ... Coroner's Office to the Burke Museum in 1965 (Burke Accn. 1966-77). All human remains are now missing. No... language group of Salish cultures. The Duwamish people primarily occupied this area, specifically the Lake people (Swanton 1952:423). In the 1870s, as the City of Seattle developed, the Lake people were...

  20. Ph.D. shortage

    Science.gov (United States)

    The late 1990s will see a shortage of Ph.D. graduates, according to the Association of American Universities, Washington, D.C. AAU's new comprehensive study, “The Ph.D. Shortage: The Federal Role,” reports that competition for new Ph.D.s is already intense and can only intensify because demand is greater than supply in both academic and nonacademic markets.Doctoral education plays an increasingly important role in U.S. research and development programs. Students have a pivotal part in doing research and enriching it with new ideas. The AAU report says that graduate students are “major determinants of the creativity and productivity of U.S. academic research, the source of more than 50% of the nation's basic research.’ The market for doctoral education extends beyond the university. In 1985, about 43% of all Ph.D.s employed in this country were working outside higher education; the demand for doctorate recipients in nonacademic sectors continues to grow.

  1. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  2. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  3. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2000-06-01

    Full Text Available Report of PhD Dissertations.   Miguel Calleja Puerta El conde Suero Vermúdez, su parentela y su entorno social. La aristocracia leonesa en los siglos XI y XII, Tesis de doctorado en Historia, Universidad de Oviedo (España, 2000   Adele Cilento Potere e monachesimo nella Calabria bizantina: relazioni e interferenze (secc. IX-XI, Tesi di dottorato di ricerca in Storia medievale (X ciclo, Università degli Studi di Torino, 2000   Amedeo De Vincentiis Firenze e i signori. Sperimentazioni istituzionali e modelli di regime nelle signorie fiorentine degli Angioini (fine XIII - metà XIV secolo, Tesi di dottorato di ricerca in Storia medioevale (XI ciclo, Università degli Studi di Milano, 1999   Marco Folin Il sistema politico di un antico Stato italiano: i ducati estensi nella prima Età moderna (1452-1598, Tesi di dottorato di ricerca in Storia, Scuola Normale superiore di Pisa, 2000   Barbara Frale Guardiani del Santuario. Le radici orientali del processo contro l’ordine del Tempio (1128 - 1314, Tesi di dottorato di ricerca in Storia sociale d’Europa (XI ciclo, Università "Ca’ Foscari" di Venezia, 2000

  4. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003

  5. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  6. Functional characterization and evaluation of in vitro protective efficacy of murine monoclonal antibodies BURK24 and BURK37 against Burkholderia pseudomallei.

    Directory of Open Access Journals (Sweden)

    Bhavani V Peddayelachagiri

    Full Text Available Burkholderia pseudomallei, the causative agent of melioidosis has been recognized by CDC as a category B select agent. Although substantial efforts have been made for development of vaccine molecules against the pathogen, significant hurdles still remain. With no licensed vaccines available and high relapse rate of the disease, there is a pressing need for development of alternate protection strategies. Antibody-mediated passive protection is promising in this regard and our primary interest was to unravel this frontier of specific mAbs against Burkholderia pseudomallei infections, as functional characterization of antibodies is a pre-requisite to demonstrate them as protective molecules. To achieve this, we designed our study on in vitro-based approach and assessed two mAbs, namely BURK24 and BURK37, reactive with outer membrane proteins and lipopolysaccharide of the pathogen respectively, for their ability to manifest inhibitory effects on the pathogenesis mechanisms of B. pseudomallei including biofilm formation, invasion and induction of apoptosis. The experiments were performed using B. pseudomallei standard strain NCTC 10274 and a clinical isolate, B. pseudomallei 621 recovered from a septicemia patient with diabetic ailment. The growth kinetic studies of the pathogen in presence of various concentrations of each individual mAb revealed their anti-bacterial properties. Minimal inhibitory concentration and minimal bactericidal concentration of both the mAbs were determined by using standards of Clinical and Laboratory Standards Institute (CLSI and experiments were performed using individual mAbs at their respective bacteriostatic concentration. As an outcome, both mAbs exhibited significant anti-Burkholderia pseudomallei properties. They limited the formation of biofilm by the bacterium and completely crippled its invasion into human alveolar adenocarcinoma epithelial cells. Also, the mAbs were appreciably successful in preventing the

  7. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2002-06-01

    Full Text Available Report of PhD dissertation. Laura Baietto Una politica per le città. Rapporti fra papato, vescovi e comuni nell'Italia centro-settentrionale da Innocenzo III a Gregorio IX, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Torino, 2002   Giuseppe Banfo Compresenze e sovrapposizioni di poteri territoriali di qualità diversa tra X e XIII: il caso del basso Monferrato, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2002   Francesca Dell'Acqua La vetrata tra l'età tardo imperiale e l'altomedioevo: le fonti, l'archeologia, Tesi di Perfezionamento in Storia dell'Arte Medievale, Scuola Normale Superiore di Pisa, 2001   Primo Giovanni Embriaco I vescovi di Albenga e gli sviluppi signorili nella Liguria occidentale (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Torino, 2001   Antonella Ghignoli Documenti e proprietà altomedievali. Fondamenti e problemi dell'esegesi storica delle fonti documentarie nello specchio della tradizione delle carte pisane dei secoli VIII-XI, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002   Vito Loré Espansione monastica e mutamenti politici. La Trinità di Cava nei suoi rapporti con i sovrani longobardi e normanni e con l'aristocrazia territoriale. Secoli XI-XII, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Firenze, 2002   Rosaria Stracuzzi Messina nel '400, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001   Stefania Tamburini Le "portate" ecclesiastiche nel piviere di San Giovanni in Firenze nel 1427. Spunti per una riflessione sul patrimonio ecclesiastico della diocesi fiorentina,Tesi di dottorato di ricerca in Storia e informatica, Università degli Studi di Bologna, 2001

  8. 78 FR 50109 - Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Science.gov (United States)

    2013-08-16

    ... cultural items listed in this notice meet the definition of unassociated funerary objects. Lineal... repatriate cultural items under the control of the Burke Museum, Seattle, WA, that meet the definition of... Lisk families occupied the property. The Lisk family was of Kikiallus heritage. The site described...

  9. 75 FR 436 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-01-05

    ... the determination. Both sites are on the western shore of Lake Washington and near Union Bay. This... mouth of the Sammamish River and northeastern Lake Washington. This area falls within the Southern... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State...

  10. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-12-01

    Full Text Available Report of PhD Dissertations. Massimo Della Misericordia Divenire comunità. Comuni rurali, poteri signorili, identità sociali in Valtellina e nella montagna lombarda nel tardo medioevo, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Torino, 2003   Mariano Dell’Omo Il monastero di S. Liberatore alla Maiella centro dell’irradiazione di Montecassino nell’Abruzzo medievale e moderno. Contributo alla storia dell’organizzazione patrimoniale e della civiltà monastica cassinese nell’Italia centrale attraverso i documenti di S. Liberatore conservati nell’Archivio di Montecassino. Introduzione storica, paleografica e archivistica. Edizione dei documenti più antichi (†798-1000 e regesti di quelli posteriori (1005-1735, Tesi di dottorato in Storia Ecclesiastica, Facoltà di Storia Ecclesiastica, Pontificia Università Gregoriana di Roma,  2004   Giulia Lorenzoni Conquistare e governare la città. Forme di potere e istituzioni nel primo anno della signoria viscontea a Bologna (ottobre 1350-novembre 1351, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Bologna, 2004   Federica Monteleone Il viaggio di Carlo Magno in Terra Santa. Un’esperienza di pellegrinaggio nella tradizione europea occidentale, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo   Francesca Pucci Donati Fra teorie mediche e pratica quotidiana: i calendari dietetici dell’Occidente latino altomedievale (secoli IX-XI, Tesi di dottorato di ricerca in Storia medievale (XV ciclo, Università degli studi di Bologna, 2004 Alberto Ricciardi L’Epistolario di Lupo di Ferrières come fonte per la storia degli intellettuali nell’età di Carlo il Calvo, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Francesco Paolo Terlizzi I trattati dell'Anonimo Normanno: ricerche di ecclesiologia, Tesi

  11. Arnold Aberman, MD.

    Science.gov (United States)

    Aberman, A

    1995-10-01

    When the United States embarked on its effort to provide universal health insurance, the Canadian Medicare System was cited as a possible model for American health care. Often touted as an example of low-cost, high quality medicine, the Canadian system has mirrored the problems of health care across its southern border. With rocketing health care expenditures and financing having largely been decentralized to the individual provinces, local officials have struggled to cut costs and services. A central focus of these efforts has been a move to decrease the numbers of physicians, most notably a 10% decrease in medical school class size in 1993. While some Western provinces have experimented with the privatization of health care, the Canadian system still remains the epitome of government operated fee-for-service medicine. Given the likelihood of dramatic change in the American Medicare system, Canadian academic centers offer a unique perspective on the impact of capitation, evolving relationships with government payors, and the flip side of market oriented reforms. At the helm of one of Canada's largest schools is Arnold Aberman, MD, dean of the University of Toronto Faculty of Medicine. Born in Montreal, Quebec, Aberman received his MD from McGill University, but then did his residency both in Canada and the US, followed by a pulmonary fellowship at Albert Einstein College of Medicine and the Cardiovascular Research Institute of the University of California, San Francisco. Interviewed at his office in Toronto, Aberman reflected on the trials and tribulations confronting medicine on both sides of the 48th parallel.

  12. BurkDiff: A Real-Time PCR Allelic Discrimination Assay for Burkholderia Pseudomallei and B. mallei

    OpenAIRE

    Jolene R Bowers; Engelthaler, David M.; Jennifer L Ginther; Talima Pearson; Peacock, Sharon J; Apichai Tuanyok; Wagner, David M.; Currie, Bart J.; Keim, Paul S.

    2010-01-01

    A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a ro...

  13. BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei.

    Directory of Open Access Journals (Sweden)

    Jolene R Bowers

    Full Text Available A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei.

  14. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  15. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  16. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative resear

  17. Contending for liberty : principle and party in Montesquieu, Hume, and Burke

    OpenAIRE

    Elliott, Sean

    2010-01-01

    This thesis explores the political reformation of “faction” in the political thought of Montesquieu, David Hume, and Edmund Burke, three thinkers whose works span what Pierre Manent calls “an exquisite moment of liberalism.” It examines the transformation of faction from one based largely on class to one based largely on political function and argues that as the political emphasis of “party” overtook that of class, a disconnect in constitutional theory appeared between the principles formerl...

  18. Burke Porter研发的三机器人轮胎生产线

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Burke E Porter机械公司(BEPCO)已研制出专利产品TRIOBO系统——进行皂洗和装配轮胎的三机器人工作间概念。此系统将成为推动此类技术发展的催化剂。TRIOBO独有的特性是它仅用三个机器人,每个机器人都完成不同的功能:

  19. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael..., M.D., Daniel P rez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garc a Nieves, M.D., Francis... and Dr. Daniel Perez, met with Humana representatives to discuss the 20 percent COB. During...

  20. [Professor Andelko Wolf, MD, PhD. (1922-2007), eminent epidemiologist and dermatovenerologist].

    Science.gov (United States)

    Gruber, Franjo; Peris, Zdravko

    2009-01-01

    Professor Andelko Wolf graduated medicine from the University of Zagreb School of Medicine in 1947. First he specialised in epidemiology and became head of the Brucellosis Centre in Rijeka for the Istria region. Later he also specialised in dermatovenerology at the Department for Skin and Venereal diseases in Rijeka. He passed the specialty board exam in dermatovenerology in 1958 and became teaching assistant. In 1973, he became assistant professor and in 1981 full professor. At the Department he founded the Laboratory for Mycology and allergology. Later he focused on occupational skin diseases and photodermatology. His doctoral thesis was on the action of light on the skin. He chaired the Clinic and was a member of various Hospital and Medical School committees. He was an excellent clinician undergraduate and graduate student teacher in Rijeka and Zagreb. He published around eighty papers on dermatology, but also on the necessity to reform medical studies. PMID:20500011

  1. In Remembrance of Robert J. Arceci, M.D., Ph.D. | Office of Cancer Genomics

    Science.gov (United States)

    It is with great sadness and a profound sense of loss that OCG recognizes the untimely passing of Dr. Robert J. Arceci. Dr. Arceci was a co-Principal Investigator for the Acute Myeloid Leukemia (AML) project within the TARGET initiative, which aims to discover novel, more effective treatments for childhood cancers. Dr. Arceci was passionate about the use of cancer genomics to both inform therapeutic approaches in the clinic and expand the field of precision medicine.

  2. Urbanism PhD Research 2008 - 2010

    NARCIS (Netherlands)

    Van der Hoeven, F.D.; Brand, N.; Van der Burg, L.; Çalışkan, O.; Tan, E.R.; Wang, C.-Y.; Zhou, J.

    2009-01-01

    To ensure the quality of the Ph.D. research the Department introduced a special procedure for periodic evaluation: after a period of nine months the potential Ph.D. candidates are asked to present their research design, theoretical framework and methodological approach to the members of the Departme

  3. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  4. Approaching Corporate Social Responsibility through Kenneth Burke's Notions of Terministic Screens and Entitlement

    DEFF Research Database (Denmark)

    Kampf, Constance

    allow for user agency, whereas entitlement appears to be focused more at the cultural level, with the agency shared by the 'tribe,' the language itself, and the context of situation.1 In other words, "terministic screens" appear to be extrinsic, while "entitlement" appears to be intrinsic.  Carmichael...... and extrinsic can change places, the interpretive process of "terministic screens" and the constitutive process of "entitlement" may well be reciprocal.  The implications of this reciprocity can be used as a basis for understanding the linguistic and cultural components of Corporate Social Responsibility...... as portrayed in corporate web presences around the world.  This paper will use Burke's concepts of entitlement and terministic screens to compare and contrast the manner in which Corporate Social Responsibility is constituted and interpreted from culture to culture as it grows into a global movement...

  5. Factors related to establishment of Prosopis caldenia Burk. seedlings in central rangelands of Argentina

    Science.gov (United States)

    de Villalobos, A. E.; Peláez, D. V.; Elia, O. R.

    2005-03-01

    Prosopis caldenia Burk. is one of the woody species that is increasing in abundance due to poor grazing management in the semi-arid phytogeographic region of central Argentina, commonly known as the Caldenal. The objective of this study was to evaluate the effect of herbaceous cover, cattle dung, soil disturbance, and water supply on emergence and survival of P. caldenia seedlings on sites with different grazing histories: (i) a site exposed to long-term continuous grazing by cattle (grazed site), and (ii) a long-term exclosure to domestic livestock (ungrazed site). Removal of grass cover, addition of cattle dung, and water supply enhanced seedling emergence and survival, especially in the grazed site. Results suggest that factors (direct and indirect) associated with prolonged grazing history markedly affect P. caldenia establishment. This in turn alters the grass-woody plant balance, which might reduce the potential capacity of livestock production in the Caldenal.

  6. ATLAS PhD Grant Scheme

    CERN Multimedia

    2016-01-01

    In this #CERNandSociety video, the 3 PhD students, awarded the ATLAS PhD Grant in 2015, talk about their research work within the ATLAS Collaboration and how this experience has shaped their future. Find out more about the ATLAS PhD Grant Scheme: cern.ch/ATLASPhDGrant This programme is just one of the many #CERNandSociety projects at CERN. Find out more and how you can be involved: http://cern.ch/go/pBt7

  7. The Main Diseases and Control Measures of Panax notoginseng(Burk) F. H. Chen in Wuzhou City

    Institute of Scientific and Technical Information of China (English)

    Chen; Yinghui; Liu; Zhuowu; Qiu; Weihua; Tan; Xinxing; Li; Jinfeng

    2014-01-01

    The main symptoms of root rot,anthracnose,blight and damping-off of Panax notoginseng( Burk) F. H. Chen are introduced in the paper,and the corresponding control measures are elaborated from the aspects of agricultural management measures,seed disinfection,seedbed treatment and chemical control.

  8. Brenda K. Edwards, PhD

    Science.gov (United States)

    Brenda K. Edwards, PhD, has been with the Surveillance Research Program (SRP) and its predecessor organizations at the National Cancer Institute (NCI) since 1989, serving as SRP’s Associate Director from 1990-2011.

  9. What PhD students really want

    CERN Document Server

    Mao, Minnie

    2010-01-01

    The road to becoming an astronomer is exciting, but often fraught with danger and conflicting messages. A PhD student is inundated with catch-phrases such as "publish or perish" and "it's not about the quantity, but the quality of work". How do we know which advice to follow? How can we publish copious amounts of quality work in only three years so as to maximize our success in the future? How do we even know what "good quality" really is? With only a short time to prepare ourselves for the big wide world of Astronomy, what is the best way for a PhD student to maximize their research and ultimately maximize their success as a real astronomer? The PhD students of today are the astronomers of tomorrow, but their journey depends on a positive work environment in which they can thrive and improve. Here I present the results of a survey of current PhD students on how they believe they can maximize their success in science. I find that PhD students in Australia expect to write more papers during their PhD than is e...

  10. A workshop on leadership for senior MD-PhD students

    OpenAIRE

    Meador, Catherine B.; Parang, Bobak; Musser, Melissa A.; Haliyur, Rachana; Owens, David A.; Terence S Dermody

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD–PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a hi...

  11. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  12. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  13. Interview with Di Gao PhD

    Directory of Open Access Journals (Sweden)

    Di Gao

    2016-04-01

    Full Text Available Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP to support USP monograph modernization and since June 2014 she has been working in her current position at AstraZeneca. Recently, she won a prestigious award from Women in Bio (WIB. WIB is an organization of professionals committed to promoting careers, leadership and entrepreneurship for women in the life sciences. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  14. Interview with Di Gao PhD

    OpenAIRE

    Di Gao

    2016-01-01

    Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP) to support USP monograph modernization and since June 2014 she has been working in her current p...

  15. ATLAS PhD Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  16. Interaction in PhD supervision

    DEFF Research Database (Denmark)

    Kobayashi, Sofie; Grout, Brian William Wilson; Rump, Camilla Østerberg

    D student, her principal supervisor and two co-supervisors. The analysis is informed by positioning theory, where a conversation is viewed as a tri-polar structure of speech-act, positioning, and storylines. Positioning is the act of assigning rights and duties to oneself and to others and storylines......This paper contains an analysis of a single supervision session, undertaken with the aim of identifying how learning opportunities might be created for a PhD student. The supervision session concerned methodologies to be employed in a PhD study related to storm water management and included the Ph...

  17. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  18. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  19. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  20. What My Ph.D. Taught Me

    Science.gov (United States)

    Levenstein, Jessica

    2013-01-01

    The author started in the Ph.D. program in comparative literature at Princeton in 1992, a year after she graduated from college. She fell in love with mythology and the classical traditions and find herself teaching literature. In the remainder of her time at Princeton, she precepted for four or five more classes, got the chance to join the…

  1. Gaussian Mixture PHD Filtering with Variable Probability of Detection

    OpenAIRE

    Hendeby, Gustaf; Karlsson, Rickard

    2014-01-01

    The probabilistic hypothesis density (PHD) filter has grown in popularity during the last decade as a way to address the multi-target tracking problem. Several algorithms exist; for instance under linear-Gaussian assumptions, the Gaussian mixture PHD (GM-PHD) filter. This paper extends the GM-PHD filter to the common case with variable probability of detection throughout the tracking volume. This allows for more efficient utilization, e.g., in situations with distance dependent probability of...

  2. Rhetorical distance and knowledge in Burke's blurring of identification and division

    DEFF Research Database (Denmark)

    Kampf, Constance

    , reductive language process inherent in terministic screens offers an opening to reflect on both the definition and evaluation of knowledge creation processes in Ph.d. education. Although entitlement and terministic screens appear to be opposing processes, they can be understood to intersect in the formation...... of a scholar who must at once be accepted by the community for following genre conventions and disciplinary lines of thought as well as be the contributor of work that is original in nature.  Thus, the definition and evaluation of knowledge creation processes depends on a combination of reductive....... (2000). SECI, Ba and Leadership: a Unified Model of Dynamic Knowledge Creation. Long Range Planning, Volume 33, Number 1. pp. 5-34(30). Paré, A. and Smart, G. (1994). Observing Genres in Action: Towards a Research Methodology. in eds. Freedman, A. & Medway, P. Genre and the New Rhetoric. Bristol, PA...

  3. Obituary of Philip H. Cooper, MD.

    Science.gov (United States)

    Patterson, James W; Wick, Mark R; Mills, Stacey E

    2015-08-01

    Dermatopathology lost a giant in the field with the death of Philip H. Cooper, MD, on Friday, January 30, 2015. The following obituary represents a celebration of his life and his contributions to our field.

  4. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  5. Estudio fitoquímico de flores de Geoffroea decorticans (Gill. ex Hook. et Arm.) Burk, Leguminoseae (Fabaceae)

    OpenAIRE

    Silva, Raúl Alejandro; López de Ruiz, Rosa Evelia; Ruiz, Sohar Osvaldo

    2004-01-01

    Geoffroea decorticans (Gill ex Hook et Arn) Burk. Leguminoseae (Fabaceae), de nombre común "chañar" o "chañarcillo", es un árbol o arbusto de amplia distribución en la República Argentina y se usa en la medicina popular por sus virtudes emolientes, balsámicas, antitusivas y expectorantes. Aplicando la técnica de extracción con solventes de polaridad creciente fue posible aislar e identificar en la fracción soluble en éter de petróleo seis componentes. A su vez en la fracción solub...

  6. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    . The situation has thus created a paradox. On the one hand, it has become essential for institutions to have many PhD students and for the research performed to be of the highest level. On the other hand, the careers of PhD students are not necessarily going to be directly related to the research performed......The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving...... tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...

  7. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  8. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  9. 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd International Conference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent ...

  10. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  11. New Message Differences for Collision Attacks on MD4 and MD5

    Science.gov (United States)

    Sasaki, Yu; Wang, Lei; Kunihiro, Noboru; Ohta, Kazuo

    In 2005, collision resistance of several hash functions was broken by Wang et al. The strategy of determining message differences is the most important part of collision attacks against hash functions. So far, many researchers have tried to analyze Wang et al.'s method and proposed improved collision attacks. Although several researches proposed improved attacks, all improved results so far were based on the same message differences proposed by Wang et al. In this paper, we propose new message differences for collision attacks on MD4 and MD5. Our message differences of MD4 can generate a collision with complexity of less than two MD4 computations, which is faster than the original Wang et al.'s attack, and moreover, than the all previous attacks. This is the first result that improves the complexity of collision attack by using different message differences from Wang et al.'s. Regarding MD5, so far, no other message difference from Wang et al.'s is known. Therefore, study for constructing method of other message differences on MD5 should be interesting. Our message differences of MD5 generates a collision with complexity of 242 MD5 computations, which is slower than the latest best attack. However, since our attack needs only 1 bit difference, it has some advantages in terms of message freedom of collision messages.

  12. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  13. Pursuit of the Ph.D.

    Directory of Open Access Journals (Sweden)

    Scott P. Kerlin

    1995-11-01

    Full Text Available he thesis is put forward that changes in public policy which originally promoted broad access to higher education are leading to the diminished likelihood that minorities, those from low-income backgrounds and females in underrepresented disciplines will pursue, or be able to complete, the doctorate. By reviewing a wide range of research literature and statistical reports on the status of doctoral education in the U.S. & Canada, a detailed sociological portrait of those who pursue the Ph.D. is presented. Recommendations are given for further research on doctoral education, particularly in areas of attrition,retention, student indebtedness, social stratification, and post-doctoral career plans.

  14. Understanding Non-Traditional PhD Students Habitus--Implications for PhD Programmes

    Science.gov (United States)

    Naidoo, Devika

    2015-01-01

    Against the background of vast changes in doctoral education and the emergence of non-traditional doctoral programmes, this paper investigates the habitus of non-traditional PhD students at a South African university. Bourdieu's conceptual tool of habitus informed the study. In-depth and open-ended interviews were conducted with 10 non-traditional…

  15. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... Deadline Date: 10/02/2013. ADDRESSES: Submit completed loan applications to: U.S. Small...

  16. Peter Burke, Hibridismo Cultural, Ediciones Akal, Madrid, 2010 (Trad. Sandra Chaparro Martínez) 158 p.

    OpenAIRE

    Brower Beltramin, Jorge

    2012-01-01

    Peter Burke, uno de los historiadores de la cultura más notables de las últimas décadas,  nos entrega en este texto,  un ensayo teórico iluminador y sugerente en torno a uno de los fenómenos frecuentemente analizados en estos tiempos de globalización: el hibridismo cultural. Antes de referirnos a la arquitectura conceptual de este magnífico ensayo teórico es necesario hacer una referencia al estudio preliminar realizado por la profesora María José  del Río Barredo para la edición en español d...

  17. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  18. Predicting Computer Science Ph.D. Completion: A Case Study

    Science.gov (United States)

    Cox, G. W.; Hughes, W. E., Jr.; Etzkorn, L. H.; Weisskopf, M. E.

    2009-01-01

    This paper presents the results of an analysis of indicators that can be used to predict whether a student will succeed in a Computer Science Ph.D. program. The analysis was conducted by studying the records of 75 students who have been in the Computer Science Ph.D. program of the University of Alabama in Huntsville. Seventy-seven variables were…

  19. Ante Šiljeg, PhD in Interdisciplinary Sciences

    Directory of Open Access Journals (Sweden)

    Sanja Lozić

    2013-12-01

    Full Text Available Ante Šiljeg defended his doctoral thesis The Digital Relief Model in Analysis of Geomorphometric Parameters – Example of PP Vrana Lake at Faculty of Science, University of Zagreb on June 20th, 2013 (supervisor Sanja Lozić, PhD, assistant professor and received a PhD degree in the field of interdisciplinary science, field of geography, branch of applied geography. Doctoral thesis was defended in front of committee composed of Mladen Pahernik, PhD, assistant professor, Danijel Orešić, PhD, associate professor and Aleksandar Toskić, PhD, associate professor. Commitee for disertation review was in the same composition.

  20. ['Sandwich PhD': considerations for a successful experience abroad].

    Science.gov (United States)

    Salvetti, Marina de Goes; Bueno, Mariana; Gastaldo, Denise; Kimura, Amélia Fumiko; Pimenta, Cibele Andrucioli de Mattos

    2013-03-01

    International PhD internship, named "Sandwich PhD" in Brazil is an opportunity to improve research abilities, to become known in academic area and to establish and/or increase work opportunities in an international context. In this article, we describe key factors regarding the planning and development of the "Sandwich PhD" as experienced by professors and students involved in the collaboration between the School of Nursing, University of São Paulo and Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Canada. We also present the participation of PhD students' network as an alternative to the "Sandwich PhD". An international experience, when well-planned and developed correctly, promotes students' personal and professional development and favors the internationalization of Brazilian graduate programs and research groups.

  1. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    OpenAIRE

    Armand Faganel

    2008-01-01

    The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent o...

  2. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  3. Direct NOE simulation from long MD trajectories

    Science.gov (United States)

    Chalmers, G.; Glushka, J. N.; Foley, B. L.; Woods, R. J.; Prestegard, J. H.

    2016-04-01

    A software package, MD2NOE, is presented which calculates Nuclear Overhauser Effect (NOE) build-up curves directly from molecular dynamics (MD) trajectories. It differs from traditional approaches in that it calculates correlation functions directly from the trajectory instead of extracting inverse sixth power distance terms as an intermediate step in calculating NOEs. This is particularly important for molecules that sample conformational states on a timescale similar to molecular reorientation. The package is tested on sucrose and results are shown to differ in small but significant ways from those calculated using an inverse sixth power assumption. Results are also compared to experiment and found to be in reasonable agreement despite an expected underestimation of water viscosity by the water model selected.

  4. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  5. MD5的Keygenme分析

    Institute of Scientific and Technical Information of China (English)

    Firebig

    2006-01-01

    闲来无事,抓出个不知何时下的Keygenme练练手,分析后可知.这个Keygenme有2张数据表,由注册名经MD5运算后进行查表,得出2个DWORD数据.然后再由注册码经过一个可逆循环得出2个DWORD数据.最后对比是否正确。(MD5的具体介绍黑防6期有说明)

  6. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  7. Classical MD calculations with parallel computers

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Mitsuhiro [Nagoya Univ. (Japan)

    1998-03-01

    We have developed parallel computation codes for a classical molecular dynamics (MD) method. In order to use them on work station clusters as well as parallel super computers, we use MPI (message passing interface) library for distributed-memory type computers. Two algorithms are compared: (1) particle parallelism technique: easy to install, effective for rather small number of processors. (2) region parallelism technique: take some time to install, effective even for many nodes. (J.P.N.)

  8. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  9. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  10. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  11. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  12. Contenido de los nutrientes básicos en Catolaccus grandis Burks criados sobre larvas del picudo del algodon

    Directory of Open Access Journals (Sweden)

    ARAUJO LÚCIA HELENA AVELINO

    2000-01-01

    Full Text Available El objetivo del trabajo fue determinar los niveles de carbohidratos, proteínas solubles y aminoácidos libres de larvas, pupas hembras y adultos hembras de Catolaccus grandis (Burks (Hymenoptera: Pteromalidae criados sobre larvas del picudo del algodón envenenadas por hembras del parasitoide y por larvas de primer instar del parasitoide. Esto estudio fue conducido en la Unidade de Investigación de Control Biologico de Plagas del Departamento de Agricultura de los Estados Unidos de la América, en Weslaco, Texas. Las 20 muestras de cada uno de los tres estados de desarrollo: tercer instar larval, pupas hembra y adultos hembra del parasitoide C. grandis, fueron separadas y pesadas individualmente y se cuantió el contenido de carbohidratos totales, proteínas solubles totales y aminoácidos libres criados en diferentes sustratos. Los resultados obtenidos confirman la existencia de patrones metabólicos significativamente distintos de estos nutrientes básicos.

  13. 2. mednarodna konferenca My PhD = 2nd My phd International Conference

    Directory of Open Access Journals (Sweden)

    Armand Faganel

    2008-09-01

    Full Text Available The article presents the organization of the second My phd InternationalConference organized in June in Bratislava. The organizer Friedrich Ebert Foundation is a German non-profit organization. During the conference young researchers from various fields dealt with the issue of ‘New Europe’ and the challenges of sustainable development. The conference was also an opportunity for young researchers to meet new colleagues and exchange their views. The interest was very big since only 40 percent of the applicants were accepted. Another interesting thing was the competitive approach towards the conference, which means that only the best articles will be published in the conference proceedings.

  14. Information behaviour and practices of PhD students

    OpenAIRE

    Drachen, Thea Marie; Larsen, Asger Væring; Gullbekk, Eystein; Westbye, Hilde; Lach, Karin

    2011-01-01

    This report addresses the information behaviour and practices of PhD students and its implications for library services. Academic libraries and their services are part of the information network of PhD students. Therefore libraries should pay special attention to the needs and practices of this important academic subgroup. The University Librarian at Copenhagen University Library and Information Service (CULIS) commissioned this study. It was conducted by representatives from CULIS, Universit...

  15. The PhD in Writing Accompanied by an Exegesis

    Science.gov (United States)

    Arnold, Josie

    2005-01-01

    The position of this paper is to further the discussion on what constitutes academic assessment in the PhD by artefact and exegesis. In doing so, it explores some of the ideas that arose in setting up the PhD in creative writing at Swinburne University of Technology. Thus, I: (1) survey some of the questions that arise about the journeys made by…

  16. A Gaussian Mixture PHD Filter for Extended Target Tracking

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2010-01-01

    In extended target tracking, targets potentially produce more than one measurement per time step. Multiple extended targets are therefore usually hard to track, due to the resulting complex data association. The main contribution of this paper is the implementation of a Probability Hypothesis Density (PHD) filter for tracking of multiple extended targets. A general modification of the PHD filter to handle extended targets has been presented recently by Mahler, and the novelty in this work lie...

  17. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  18. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  19. MD5算法在Web开发中的应用%Application of MD5 in Web Exploitation

    Institute of Scientific and Technical Information of China (English)

    刘啸

    2014-01-01

    介绍了MD5加密技术在Web上的一些应用,给出了MD5加密实现密码在internet上安全传输的完整解决办法,给出了客户端(JavaScript)和服务器端(JavaBeans) MD5算法的实现.

  20. The Production Rate and Employment of Ph.D. Astronomers

    CERN Document Server

    Metcalfe, Travis S

    2007-01-01

    In an effort to promote self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astr...

  1. Cubature Information SMC-PHD for Multi-Target Tracking.

    Science.gov (United States)

    Liu, Zhe; Wang, Zulin; Xu, Mai

    2016-01-01

    In multi-target tracking, the key problem lies in estimating the number and states of individual targets, in which the challenge is the time-varying multi-target numbers and states. Recently, several multi-target tracking approaches, based on the sequential Monte Carlo probability hypothesis density (SMC-PHD) filter, have been presented to solve such a problem. However, most of these approaches select the transition density as the importance sampling (IS) function, which is inefficient in a nonlinear scenario. To enhance the performance of the conventional SMC-PHD filter, we propose in this paper two approaches using the cubature information filter (CIF) for multi-target tracking. More specifically, we first apply the posterior intensity as the IS function. Then, we propose to utilize the CIF algorithm with a gating method to calculate the IS function, namely CISMC-PHD approach. Meanwhile, a fast implementation of the CISMC-PHD approach is proposed, which clusters the particles into several groups according to the Gaussian mixture components. With the constructed components, the IS function is approximated instead of particles. As a result, the computational complexity of the CISMC-PHD approach can be significantly reduced. The simulation results demonstrate the effectiveness of our approaches. PMID:27171088

  2. An analysis of Ph.D. examiners' reports in engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-03-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003 and 2010 for a total of 1220 Australian Ph.D. theses by analysing examiner reports. Our analysis indicates that Ph.D. theses in engineering, N = 106, differ considerably from those in other fields in areas such as gender of candidates and examiners and the examiners' geographical location. We also found that assessment areas such as significance and contribution of the thesis, publications arising from the thesis, breadth, depth and recency of the literature review and communication and editorial correctness are areas in which the proportion of text of engineering examiners' comments differs significantly from other fields.

  3. The Training and Work of Ph.D. Physical Scientists

    Science.gov (United States)

    Smith, S. J.; Schweitzer, A. E.

    2003-05-01

    Doctoral education has often been viewed as the pinnacle of the formal education system. How useful is doctoral training in one's later career? In an NSF-funded project, we set out to perform a study of the training, careers, and work activities of Ph.D. physical scientists. The study included both in-depth interviews and a survey sent out to a sample of Ph.D. holders 4-8 years after graduation. Come and find out the results of this study: What skills are most Ph.D. physical scientists using? What should graduate programs be teaching? Are Ph.D.'s who are working in their specific field of training happier than their counterparts working different jobs? What skills and preparation lead to future job satisfaction, perhaps the most important indicator of the "success" of graduate education? A preprint and further details can be found at the project web site at: spot.colorado.edu/ phdcarer.

  4. 33 CFR 110.72 - Blackhole Creek, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Blackhole Creek, Md. 110.72... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72 Blackhole Creek, Md. The waters on the west side of Blackhole Creek, a tributary of Magothy River, southwest of a line bearing 310°30′ from the most...

  5. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  6. BI MD studies on August 25th 2011

    CERN Document Server

    Belohrad, D; Boccardi, A; Calvo, E; Dehning, B; Favier, M; Emery, J; Guerrero, A; Lefevre, T; Gras, JJ; Jeff, A; Soby, L; Rabiller, A; Roncarolo, F; Sapinski, M; Steinhagen, R; Mateo, CM

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 25-Aug-2011 (from 5 a.m. to 1 p.m.), dedicated to study Beam Loss Monitors (BLM), Wire Scanners (WS), Synchrotron Radiation (BSRT), Beam Position Monitors (BPM), and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors.

  7. MD5密码极速爆破

    Institute of Scientific and Technical Information of China (English)

    飘零雪

    2009-01-01

    MD5加密技术对我们来说并不陌生,通过MD5值可以校验下载软件的安全性,而且在很多系统中,用户的密码是以MD5值的方式保存的,用户登录时系统是把用户输入的密码计算成MD5值,然后再去和系统中保存的MD5值进行比较,以验证该用户的合法性。MD5值虽看似很安全,但也并非无懈可击,使用“超速md5破解工具”即可简单快捷地尝试解密MD5。

  8. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  9. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  10. Club of Bologna International Best PhD Prize 2012

    OpenAIRE

    Marco Fiala

    2012-01-01

    The Club of Bologna, in collaboration with UNACOMA, will be awarding a prize for the best PhD theses on subjects related to agricultural machinery design and development. Up to ten theses will be selected and the best five of these will have the chance of being presented during the annual Club of Bologna meeting that will be held from 9 to 10 November 2012, on occasion of the EIMA. The authors of the best three PhD theses will also receive a cash prize. The winners will be guests in Bologna o...

  11. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    , theoretic, and practical challenges of testing software systems, including communication protocols, services, distributed platforms, middleware, embedded systems, and security infrastructures. The aims of the ICTSS Doctoral Workshop is to provide a forum for PhD students to present preliminary results...... and their thesis work and receive constructive feedback from experts in the field as well as from peers. Also it is an opportunity for researchers to get an insight into new research topics in the field. Ph.D. students at any stage of their doctoral studies may participate. Seven abstracts were submitted...

  12. Leroy D Vandam, MD: an anesthesia journey.

    Science.gov (United States)

    Ortega, Rafael A

    2005-08-01

    Leroy D Vandam, MD was a remarkable man--an intricate amalgamation of an artist, scientist, and physician. He was a bastion of medical historical knowledge. Dr Vandam became a most influential anesthesiologist, some say, a giant. He was an example of someone who, with resolve, overcame adversity. His artwork is displayed in countless places, and several of his paintings form part of the Wood Library Museum Heritage Series. Dr Vandam was first a surgeon, but he abandoned surgery and pursued a career in anesthesiology under the leadership of Robert Dripps. He completed his residency training at the University of Pennsylvania and joined its staff in 1949. When he arrived at Brigham and Women's Hospital in the 1950s as director of anesthesia, he embarked on one of the most illustrious careers in American anesthesiology. Dr Vandam published more than 250 original articles, chapters, abstracts, and other reports on a wide variety of subjects including history, art, and pharmacology. His classic article on the complications of neuroaxial blocks is a seminal work in anesthesiology. This article describes how an anesthesiologist who shared an interest with Dr Vandam in the history of anesthesiology came to produce a movie based on his career, the evolution of anesthesia equipment, and the transformation of our specialty.

  13. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  14. Antioxidant, Antiproliferative, and Pro-Apoptotic Activities of a Saponin Extract Derived from the Roots of Panax notoginseng (Burk.) F.H. Chen

    OpenAIRE

    He, Nian-Wu; Yan ZHAO; Guo, Ling; Shang, Jun; Yang, Xing-Bin

    2012-01-01

    Dietary and medicinal uses of Panax notoginseng have been associated with reduced risk of cancer. This study was designed to investigate the profiles of P. notoginseng saponin extract (PNSE), the major bioactive ingredients in P. notoginseng (Burk.) F.H. Chen, by high-performance liquid chromatography, and, for the first time, the anticancer effect of PNSE in the human colon cancer cell line LoVo was further evaluated. The major saponins present in PNSE were ginsenosides Rg1 (31.1%) and Rb1 (...

  15. Measures for Ph.D. Evaluation: The Recruitment Process

    Science.gov (United States)

    D'Agostino, Antonella; Fruzzetti, Stefania; Ghellini, Giulio; Neri, Laura

    2011-01-01

    In the last years the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe. In the wide landscape that involves the entire HE system we draw attention on the third level of its organization, i.e. the Ph.D. In particular, this paper discusses the…

  16. An Analysis of Ph.D. Examiners' Reports in Engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-01-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003…

  17. Peer Mentorship and Transformational Learning: PhD Student Experiences

    Science.gov (United States)

    Preston, Jane P.; Ogenchuk, Marcella J.; Nsiah, Joseph K.

    2014-01-01

    The purpose of the paper is to describe our peer mentorship experiences and explain how these experiences fostered transformational learning during our PhD graduate program in educational administration. As a literature backdrop, we discuss characteristics of traditional forms of mentorship and depict how our experiences of peer mentorship was…

  18. PhD by Publication: A Student's Perspective

    Directory of Open Access Journals (Sweden)

    Peter Kanowski

    2008-01-01

    Full Text Available This article presents the first author's experiences as an Australian doctoral student undertaking a PhD by publication in the arena of the social sciences. She published nine articles in refereed journals and a peer-reviewed book chapter during the course of her PhD. We situate this experience in the context of current discussion about doctoral publication practices, in order to inform both postgraduate students and academics in general. The article discusses recent thinking about PhD by publication and identifies the factors that students should consider prior to adopting this approach, in terms of university requirements, supervisors' attitudes, the research subject matter, intellectual property, capacity and working style, and issues of co-authorship. It then outlines our perceptions of the advantages and disadvantages of undertaking a PhD by publication. We suggest that, in general, the advantages outweigh the disadvantages. We conclude by reflecting on how the first author's experiences relate to current discussions about fostering publications by doctoral students.

  19. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  20. Theo Thole as a PhD ''student''

    NARCIS (Netherlands)

    vanDuijnen, PT

    1997-01-01

    Thee Thole's Ph.D. work was the basis for the Direct Reaction Field method for incorporating a semi-classical ''solvent'' in quantum chemical calculations. The early stages of his work and later progress is reviewed and a typical example of his analytical and programming skills, so far unpublished,

  1. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  2. First International Student Obtains His PhD at CAS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Mr. Ghulam Rasul, the first international student formally enrolled by the Graduate University of CAS (GUCAS) has received his PhD degree this summer after having passed his dissertation defense on May 21 at the CAS Institute of Atmospheric Physics (IAP).

  3. MD-PhD training: looking back and looking forward.

    Science.gov (United States)

    Bonham, Ann C

    2014-01-01

    MD-PhD programs provide rigorous, integrated training for physician-scientists, enabling them to frame scientific questions in unique ways and to apply clinical insight to fundamental science. Few would question the influential contributions of MD-PhD physician-scientists in advancing medical science. In this issue of Academic Medicine, Jeffe et al affirm high levels of excellence in educational outcomes from MD-PhD training programs at U.S. MD-granting medical schools, especially programs that receive funding from the NIH Medical Scientist Training Program (MSTP). The author of this commentary observes that, in the face of current economic pressures, comprehensive, longitudinal national outcomes data from MSTP- and non-MSTP-funded MD-PhD programs will help verify the value provided by MD-PhD physician-scientists. She proposes that MD-PhD programs should better prepare the next generation of physician-scientists for future research environments, which will provide new technologies, venues, and modalities. These research environments will be more closely integrated within health care delivery systems, extend into diverse communities and regions, and employ complex technologies. MD-PhD physician-scientists also will train and gain expertise in broadening areas of research, such as health policy, health economics, clinical epidemiology, and medical informatics. Program leaders are ideally situated to foster innovative learning environments and methodologies. By sharing their innovations, they can help ensure production of a diverse MD-PhD physician-scientist workforce, prepared to engage in myriad research opportunities to meet patient and population needs in a new environment.

  4. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  5. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  6. MD5加密算法的研究

    Institute of Scientific and Technical Information of China (English)

    许琪

    2014-01-01

    MD5加密算法做为散列函数的一个重要算法,在文件校验、数字签名等诸多领域有着广泛的应用.虽然MD5加密算法是单向算法,但其仍无法抵御差分攻击和查字典攻击.文章在分析了差分攻击原理的基础上,阐述了MD5加密算法采用差分攻击产生碰撞的方法.

  7. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  8. Undertaking Individual Transdisciplinary PhD Research for Sustainable Development: Case Studies from South Africa

    Science.gov (United States)

    van Breda, John; Musango, Josephine; Brent, Alan

    2016-01-01

    Purpose: This paper aims to improve the understanding of individual transdisciplinary PhD research in a developing country context, focusing on three individual PhD case studies in South Africa. Design/Methodology/Approach: Multiple-case method was used, and three completed transdisciplinary PhD research efforts undertaken at the Stellenbosch…

  9. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  10. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  11. Find an Orthopaedic Foot and Ankle MD/DO

    Science.gov (United States)

    ... page. Home Contact Us FootCareMD Currently selected About Us Overview of Foot & Ankle Glossary of Foot & Ankle Terms Adult Foot Health ... Map American Orthopaedic Foot & Ankle Society ® Orthopaedic Foot ... US) Copyright © 2016 All Rights Reserved

  12. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  13. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  14. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  15. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.

    Directory of Open Access Journals (Sweden)

    Wei Wei

    Full Text Available BACKGROUND: Soybean [Glycine max (L. Merr.] is one of the most important crops for oil and protein resource. Improvement of stress tolerance will be beneficial for soybean seed production. PRINCIPAL FINDINGS: Six GmPHD genes encoding Alfin1-type PHD finger protein were identified and their expressions differentially responded to drought, salt, cold and ABA treatments. The six GmPHDs were nuclear proteins and showed ability to bind the cis-element "GTGGAG". The N-terminal domain of GmPHD played a major role in DNA binding. Using a protoplast assay system, we find that GmPHD1 to GmPHD5 had transcriptional suppression activity whereas GmPHD6 did not have. In yeast assay, the GmPHD6 can form homodimer and heterodimer with the other GmPHDs except GmPHD2. The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization. Transgenic Arabidopsis plants overexpressing the GmPHD2 showed salt tolerance when compared with the wild type plants. This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes. SIGNIFICANCE: These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator.

  16. 基于MD5和Session的PHP安全防范%PHP security based on Session and MD5

    Institute of Scientific and Technical Information of China (English)

    何秉荣

    2014-01-01

    根据Session工作原理和MD5算法的特性,分析了PHP中Session欺骗与攻击手段,并较有针对性地在防范Session攻击的技术中结合MD5函数,从而提出了一个较为有效、实用的防范措施.

  17. Club of Bologna International Best PhD Prize 2012

    Directory of Open Access Journals (Sweden)

    Marco Fiala

    2012-06-01

    Full Text Available The Club of Bologna, in collaboration with UNACOMA, will be awarding a prize for the best PhD theses on subjects related to agricultural machinery design and development. Up to ten theses will be selected and the best five of these will have the chance of being presented during the annual Club of Bologna meeting that will be held from 9 to 10 November 2012, on occasion of the EIMA. The authors of the best three PhD theses will also receive a cash prize. The winners will be guests in Bologna of UNACOMA who will cover travelling expenses and hotel accommodation for 2 nights. They will also meet farm machinery manufacturers attending the international trade fair. The winners of the Club of Bologna Prize 2012 will be announced here. Application forms and further information can be downloaded from the Club of Bologna website (http://www.clubofbologna.org/.

  18. Lynn Sorbara, PhD | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Lynn Sorbara earned her PhD from Albert Einstein College of Medicine in 1986. Her thesis research was in the areas of the mechanism of action of the drug, Taxol, and of multidrug resistance. After postdoctoral fellowships at the Rockefeller University and the Mount Sinai College of Medicine in Manhattan, she came to the NIH as a Senior Staff Fellow in the Diabetes Branch of NIDDK. |

  19. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    OpenAIRE

    Xiaoxi Yan

    2014-01-01

    As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W funct...

  20. Extended Target Tracking Using a Gaussian-Mixture PHD Filter

    OpenAIRE

    Granström, Karl; Lundquist, Christian; Orguner, Umut

    2012-01-01

    This paper presents a Gaussian-mixture implementation of the phd filter for tracking extended targets. The exact filter requires processing of all possible measurement set partitions, which is generally infeasible to implement. A method is proposed for limiting the number of considered partitions and possible alternatives are discussed. The implementation is used on simulated data and in experiments with real laser data, and the advantage of the filter is illustrated. Suitable remedies are gi...

  1. The multisensor PHD filter: II. Erroneous solution via Poisson magic

    Science.gov (United States)

    Mahler, Ronald

    2009-05-01

    The theoretical foundation for the probability hypothesis density (PHD) filter is the FISST multitarget differential and integral calculus. The "core" PHD filter presumes a single sensor. Theoretically rigorous formulas for the multisensor PHD filter can be derived using the FISST calculus, but are computationally intractable. A less theoretically desirable solution-the iterated-corrector approximation-must be used instead. Recently, it has been argued that an "elementary" methodology, the "Poisson-intensity approach," renders FISST obsolete. It has further been claimed that the iterated-corrector approximation is suspect, and in its place an allegedly superior "general multisensor intensity filter" has been proposed. In this and a companion paper I demonstrate that it is these claims which are erroneous. The companion paper introduces formulas for the actual "general multisensor intensity filter." In this paper I demonstrate that (1) the "general multisensor intensity filter" fails in important special cases; (2) it will perform badly in even the easiest multitarget tracking problems; and (3) these rather serious missteps suggest that the "Poisson-intensity approach" is inherently faulty.

  2. Detection of haplotype mutations of the MD-2 gene promoter associated with Der p2-induced allergy using a nanostructured biosensor

    Directory of Open Access Journals (Sweden)

    Chin YT

    2014-03-01

    Full Text Available Yu-Ting Chin,1 En-Chih Liao,2 Chia-Che Wu,1 Gou-Jen Wang,1,3,4 Jaw-Ji Tsai2 1Department of Mechanical Engineering, National Chung-Hsing University, 2Department of Medical Education and Research, Taichung Veterans General Hospital, 3Graduate Institute of Biomedical Engineering, 4PhD Program in Tissue Engineering and Regenerative Medicine, National Chung-Hsing University, Taichung, Taiwan Abstract: Group 2 allergens (Der p2 have been reported to be a major cause of the human immune response to dust mite allergens. In this study, we have demonstrated for the first time the effective differentiation between haplotype mutation and normal genes in the MD-2 gene promoter using a nanostructured biosensor. A 70-mer gene fragment containing the haplotype of two single nucleotide polymorphisms in the MD-2 gene promoter region was used as a probe to detect haplotype mutations associated with Der p2-induced allergy. Discrimination was achieved using electrochemical impedance spectroscopy. The discrimination experiments employed 30 haplotype mutation samples and 30 normal target samples. The haplotype mutation samples and normal target samples could be clearly discriminated, even using samples produced by a five-cycle polymerase chain reaction process. The time and cost of sample preparation for the polymerase chain reaction process in the clinical setting can thus be reduced. Keywords: haplotype mutation detection, nanostructured biosensor, MD-2 gene promoter, electrochemical impedance spectroscopy

  3. The Added Value of a PhD in Medicine--PhD Students' Perceptions of Acquired Competences

    Science.gov (United States)

    Anttila, Henrika; Lindblom-Ylänne, Sari; Lonka, Kristi; Pyhältö, Kirsi

    2015-01-01

    PhD in the field of medicine is more common than in any other domain. Many medical doctors are driven towards PhD, but also students with other backgrounds (usually MSc) are conducting a PhD in medical schools. Higher education has invested a lot in developing generic and research competences. Still little is known about how PhD students…

  4. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  5. The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

    Directory of Open Access Journals (Sweden)

    Anna Kuchnio

    2015-08-01

    Full Text Available Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2 in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficiency reduced metastasis without affecting tumor growth. Second, it is unknown whether PHD2 regulates cancer by affecting cancer-associated fibroblasts (CAFs. We show that PHD2 haplodeficiency reduced metastasis via two mechanisms: (1 by decreasing CAF activation, matrix production, and contraction by CAFs, an effect that surprisingly relied on PHD2 deletion in cancer cells, but not in CAFs; and (2 by improving tumor vessel normalization. Third, the effect of concomitant PHD2 inhibition in malignant and stromal cells (mimicking PHD2 inhibitor treatment is unknown. We show that global PHD2 haplodeficiency, induced not only before but also after tumor onset, impaired metastasis. These findings warrant investigation of PHD2’s therapeutic potential.

  6. Applied PhD Research in a Work-Based Environment: An Activity Theory-Based Analysis

    Science.gov (United States)

    Granata, S. N.; Dochy, F.

    2016-01-01

    Activity theory is used to compare PhD undertaken at university, that is, academic PhD, with PhD performed in collaboration with industry, that is, semi-industrial PhD. The research is divided into a literature review and a case study. Semi-industrial and academic PhD are modelled as activity systems, and differences are highlighted in terms of…

  7. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  8. CoMD Implementation Suite in Emerging Programming Models

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-23

    CoMD-Em is a software implementation suite of the CoMD [4] proxy app using different emerging programming models. It is intended to analyze the features and capabilities of novel programming models that could help ensure code and performance portability and scalability across heterogeneous platforms while improving programmer productivity. Another goal is to provide the authors and venders with some meaningful feedback regarding the capabilities and limitations of their models. The actual application is a classical molecular dynamics (MD) simulation using either the Lennard-Jones method (LJ) or the embedded atom method (EAM) for primary particle interaction. The code can be extended to support alternate interaction models. The code is expected ro run on a wide class of heterogeneous hardware configurations like shard/distributed/hybrid memory, GPU's and any other platform supported by the underlying programming model.

  9. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  10. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  11. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  12. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  13. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  14. Andrija Krtalić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2011-12-01

    Full Text Available Andrija Krtalić successfully defended his PhD thesis Decision Support System in Conditions of Uncertainty in Demining Activities Based on Remote Sensing Methods at the Faculty of Geodesy, University of Zagreb on 11 July 2011. The thesis was examined by an Examining Committee composed of Prof. Emer. Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine, Prof. Dr. Renata Pernar (Faculty of Forestry, University of Zagreb, Prof. Dr. Hrvoje Gold (Faculty of Traffic Sciences in Zagreb and Prof. Dr. Milan Bajić (supervisor.

  15. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  16. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  17. 77 FR 12476 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore..., across Curtis Creek, mile 1.0, at Baltimore, MD. This deviation allows the bridge to operate on...

  18. 75 FR 54069 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-09-03

    ... (75 FR 30747-30750). The rulemaking concerned eliminating the need for a bridge tender by allowing the... SECURITY Coast Guard 33 CFR Part 117 RIN 1625--AA09 Drawbridge Operation Regulations; Curtis Creek... Avenue Bridge, at mile 0.9, across Curtis Creek at Baltimore, MD. The requested change would have...

  19. 76 FR 9225 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2011-02-17

    ... Regulations; Curtis Creek, Baltimore, MD'' in the Federal Register (74 FR 50707). The temporary deviation... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... changing the drawbridge operation regulations of the Pennington Avenue Bridge, across Curtis Creek, mile...

  20. 75 FR 1705 - Drawbridge Operation Regulations; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-01-13

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Curtis Creek... operation of the I695 Bridge across Curtis Creek, mile 0.9, at Baltimore, MD. The deviation is necessary to... section of Curtis Creek and the bridge will not be able to open in the event of an emergency. Coast...

  1. 75 FR 50707 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-08-17

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Curtis Creek, Baltimore... operation of the Pennington Avenue Bridge, across Curtis Creek, mile 0.9, at Baltimore, MD. This deviation... vessels bound for the Coast Guard Yard at Curtis Bay, as well as a significant amount of commercial...

  2. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  3. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  4. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... proposed rulemaking the bridge owner displayed on the Wise Avenue Bridge signage that stated a 48-hour advance notice was required to open the draw bridge. This signage portrayed improper...

  5. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  6. Human radiation studies: Remembering the early years: Oral history of radiologist Henry I. Kohn, M.D., Ph.D., conducted September 13, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Henry I. Kohn by representatives of the US DOE Office of Human Radiation Experiments. Dr. Kohn was selected for this interview because of the positions he held at Oak Ridge National Laboratory, University of California at San Francisco, and Harvard Medical School. Dr. Kohn discussed his remembrances of his experiences in blood chemistry of animals and patients exposed to radiation, and his remembrances of several radiobiologists

  7. Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995

    International Nuclear Information System (INIS)

    This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory

  8. Human radiation studies: Remembering the early years. Oral history of Dr. John W. Gofman, M.D., Ph.D., December 20, 1994

    International Nuclear Information System (INIS)

    Dr. John W. Gofman was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE) concerning his research at the University of California, Berkeley and his biomedical work at Lawrence Livermore Radiation Laboratory. Following a short biographical sketch, Dr. Gofman relates his remembrances with the discovery and chemistry of uranium-233, the Manhattan project, laboratory production of the first milligram of plutonium, pre-1945 medical use of high-dosage radiation, medical treatments with phosphorus 32, and fallout. Dr. Gofman also discusses his relationships with Professor Oppenheimer, Joe Hamilton, Ernest Lawrence, and other. Then Dr. Gofman describes his pioneering work on his true interests concerning heart disease, heparin, and lipoproteins. Finally intra-AEC political issues are discussed relating to testing of atomic weapons

  9. Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995

    International Nuclear Information System (INIS)

    NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee

  10. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    Directory of Open Access Journals (Sweden)

    Wolpert Lewis

    2010-08-01

    Full Text Available Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  11. Alexandros Zaoussis, MD, PhD (1923-2005): An Orthopedic Surgeon and Historian and His Contribution to the Establishment of Hip Surgery.

    Science.gov (United States)

    Markatos, Konstantinos; Korres, Demetrios

    2016-10-01

    The purpose of our study was to summarize all the knowledge concerning the innovative pioneer in the field of orthopedic surgery and especially hip replacement, Alexandros Zaoussis (1923-2005). He was a pioneer in hip replacement, and he contributed to several fields of orthopedic surgery with his clinical work and his international publications. He was also an eminent historian of World War II and of the Greek Resistance to the Nazi occupation in which he played a significant part. A thorough study of texts, medical books, and reports in the field of history of medicine, together with a review of the available literature in PubMed, was undertaken. He was an eminent clinical director of orthopedics who had significant contribution in teaching, practicing, and expanding the horizons of orthopedic surgery in the 20th century. A thorough review of medical texts, books, and publications in the Greek academic press was undertaken to summarize his contributions and his turbulent life to commemorate the 10th anniversary of his death. PMID:27126253

  12. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    OpenAIRE

    Wolpert Lewis

    2010-01-01

    Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  13. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  14. I-determinants for a successful PhD or postdoctoral outcome.

    Science.gov (United States)

    Sørensen, Henrik Toft

    2016-01-01

    Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student's skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an "I" and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the personal characteristics of a researcher play a very important role in the quality of research. Application of some of the principles mentioned in this article might allow decision to reach a more evidence-based way to recruit PhD students and postdoctorals. PMID:27574466

  15. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  16. Research(er) at Home: Auto/Ethnography of (My) PhD

    Science.gov (United States)

    Benová, Kamila

    2014-01-01

    This article deals with the PhD phase of tertiary higher education (in Slovakia), which is here considered as the specific phase of the academic career. It tries to answer the question: what is the PhD, in the context of research, theoretically and methodologically approached as a critical ethnography of higher education. It is focused on the…

  17. The Training, Careers, and Work of Ph.D. Physical Scientists: Not Simply Academic.

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-01-01

    Presents an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Concludes that use of specialized training varies widely with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other…

  18. Innovation in PhD Completion: The Hardy Shall Succeed (And Be Happy!)

    Science.gov (United States)

    Kearns, Hugh; Gardiner, Maria; Marshall, Kelly

    2008-01-01

    What is it that makes a PhD such a difficult process, and prevents candidates from completing on time? In this paper, we propose that self-sabotaging behaviours, including overcommitting, procrastination and perfectionism, have a role to play. At Flinders University, we have developed a program in which we work with PhD students to help to reduce…

  19. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  20. Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.

    Science.gov (United States)

    He, Nian-Wu; Zhao, Yan; Guo, Ling; Shang, Jun; Yang, Xing-Bin

    2012-04-01

    Dietary and medicinal uses of Panax notoginseng have been associated with reduced risk of cancer. This study was designed to investigate the profiles of P. notoginseng saponin extract (PNSE), the major bioactive ingredients in P. notoginseng (Burk.) F.H. Chen, by high-performance liquid chromatography, and, for the first time, the anticancer effect of PNSE in the human colon cancer cell line LoVo was further evaluated. The major saponins present in PNSE were ginsenosides Rg1 (31.1%) and Rb1 (34.4%), and the total content of the eight saponins identified (notoginsenoside R1, ginsenosides Rg1, Re, Rb1, Rc, and Rd, and isomeric ginsenosides Rb2 and Rb3) was 81.7%, indicating that it was a highly purified standardized saponin extract. Furthermore, PNSE was found to have a markedly cytotoxic effect and antiproliferative activity against the LoVo cell line in a dose- and time-dependent manner. Flow cytometry analysis demonstrated that PNSE caused cell cycle arrest at S phase. Moreover, PNSE was found to possess antioxidative capacities in the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay and hydroxyl radical scavenging assay in vitro. Taken together, the present results suggest that naturally occurring PNSE may provide significant natural defense against human colon cancer. PMID:22316295

  1. NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

    Science.gov (United States)

    Howard, Sunnie

    1998-01-01

    The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the

  2. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

    Directory of Open Access Journals (Sweden)

    Inmaculada Segura

    2016-03-01

    Full Text Available Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs, and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the actin cross-linker filamin A (FLNA as a target of PHD2 mediating these effects. In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL-mediated ubiquitination and proteasomal degradation. In hypoxia, PHD2 inactivation rapidly upregulates FLNA protein levels because of blockage of its proteasomal degradation. FLNA upregulation induces more immature spines, whereas Flna silencing rescues the immature spine phenotype induced by PHD2 inhibition.

  3. Multi-Target Detection from Full-Waveform Airborne Laser Scanner Using Phd Filter

    Science.gov (United States)

    Fuse, T.; Hiramatsu, D.; Nakanishi, W.

    2016-06-01

    We propose a new technique to detect multiple targets from full-waveform airborne laser scanner. We introduce probability hypothesis density (PHD) filter, a type of Bayesian filtering, by which we can estimate the number of targets and their positions simultaneously. PHD filter overcomes some limitations of conventional Gaussian decomposition method; PHD filter doesn't require a priori knowledge on the number of targets, assumption of parametric form of the intensity distribution. In addition, it can take a similarity between successive irradiations into account by modelling relative positions of the same targets spatially. Firstly we explain PHD filter and particle filter implementation to it. Secondly we formulate the multi-target detection problem on PHD filter by modelling components and parameters within it. At last we conducted the experiment on real data of forest and vegetation, and confirmed its ability and accuracy.

  4. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  5. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  6. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  7. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  8. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  9. On M. Mueter's Ph.D. Thesis on Cheeger deformations

    CERN Document Server

    Ziller, Wolfgang

    2009-01-01

    These are notes of a talk I gave in a seminar at the University of Pennsylvania summarizing results in the Ph.D. thesis of Michael Mueter obtained under the direction of Wolfgang Meyer at the University of Muenster. His thesis on "Kruemmungserhoehende Deformationen mittels Gruppenaktionen" examines in detail curvature properties of so called Cheeger deformations. Such deformations have been a crucial ingredient in non-negative and positive curvature constructions. His thesis contains a wealth of interesting properties of such deformations, but since it was never published, is only known to a few experts. I have no intention to publish these notes, but post them as a service to the public. A scanned version of his thesis (written in German) is available on my homepage.

  10. The Virtual Observatory Powered PhD Thesis

    CERN Document Server

    Zolotukhin, Ivan

    2010-01-01

    The Virtual Observatory has reached sufficient maturity for its routine scientific exploitation by astronomers. To prove this statement, here I present a brief description of the complete VO-powered PhD thesis entitled "Galactic and extragalactic research with modern surveys and the Virtual Observatory" comprising 4 science cases covering various aspects of astrophysical research. These comprize: (1) homogeneous search and measurement of main physical parameters of Galactic open star clusters in huge multi-band photometric surveys; (2) study of optical-to-NIR galaxy colors using a large homogeneous dataset including spectroscopy and photometry from SDSS and UKIDSS; (3) study of faint low-mass X-ray binary population in modern observational archives; (4) search for optical counterparts of unidentified X-ray objects with large positional uncertainties in the Galactic Plane. All these projects make heavy use of the VO technologies and tools and would not be achievable without them. So refereed papers published i...

  11. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    used in hospital interiors, have in previous studies been associated with increased risks of hospital acquired infections, and in hospitals today they are therefore replaced by plastic-coated upholsteries. These plastic ma- terials may improve the cleaning ef ciency, but it often side......The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... consists of a collection of 5 peer-reviewed papers, and an extended summary. The project is overall related to the construction of new Danish hospitals, where the design concept healing architecture is intro- duced in a national context, representing the vision of a promoted healing process of hospitalised...

  12. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscien...cedbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscien...cedbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  13. Researcher Profile: An Interview with Jodi Letkiewicz, Ph.D.

    Directory of Open Access Journals (Sweden)

    Jodi Letkiewicz

    2014-12-01

    Full Text Available Jodi Letkiewicz, Ph.D., is an assistant professor of finance at York University in Toronto, Ontario. She teaches in the Certified Financial Planner® Core Curriculum program preparing undergraduate students for the Canadian CFP® certification and conducts research in several areas of personal finance and consumer decision-making, including behavioral aspects influencing the decision to seek financial help, how personality traits affect financial decision-making, and the financial state of young adults, including the impact student loans have on overall well-being and financial milestones early in their adult life. Dr. Letkiewicz’s goal is to increase financial well-being in the general public, which she hopes to accomplish through teaching, research, and community outreach.

  14. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. PMID:26746591

  15. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  16. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  17. MD 346: Summary of single bunch instability threshold measurements

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Buffat, Xavier; Pieloni, Tatiana; Tambasco, Claudia; Trad, Georges; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current threshold to reach single-bunch stability in the LHC at flat top. Two bunches with dierent emittances are injected in the LHC in both B1 and B2 and the current in the Landau octupoles was progressively decreased until an instability developed. The measurements provide insight into the LHC impedance model by comparing them with the stabilizing octupole current predicted from DELPHI.

  18. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  19. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  20. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  1. Prolyl-4-hydroxylase 3 (PHD3 expression is downregulated during epithelial-to-mesenchymal transition.

    Directory of Open Access Journals (Sweden)

    Trenton L Place

    Full Text Available Prolyl-4-hydroxylation by the intracellular prolyl-4-hydroxylase enzymes (PHD1-3 serves as a master regulator of environmental oxygen sensing. The activity of these enzymes is tightly tied to tumorigenesis, as they regulate cell metabolism and angiogenesis through their control of hypoxia-inducible factor (HIF stability. PHD3 specifically, is gaining attention for its broad function and rapidly accumulating array of non-HIF target proteins. Data from several recent studies suggest a role for PHD3 in the regulation of cell morphology and cell migration. In this study, we aimed to investigate this role by closely examining the relationship between PHD3 expression and epithelial-to-mesenchymal transition (EMT; a transcriptional program that plays a major role in controlling cell morphology and migratory capacity. Using human pancreatic ductal adenocarcinoma (PDA cell lines and Madin-Darby Canine Kidney (MDCK cells, we examined the correlation between several markers of EMT and PHD3 expression. We demonstrated that loss of PHD3 expression in PDA cell lines is highly correlated with a mesenchymal-like morphology and an increase in cell migratory capacity. We also found that induction of EMT in MDCK cells resulted in the specific downregulation of PHD3, whereas the expression of the other HIF-PHD enzymes was not affected. The results of this study clearly support a model by which the basal expression and hypoxic induction of PHD3 is suppressed by the EMT transcriptional program. This may be a novel mechanism by which migratory or metastasizing cells alter signaling through specific pathways that are sensitive to regulation by O2. The identification of downstream pathways that are affected by the suppression of PHD3 expression during EMT may provide important insight into the crosstalk between O2 and the migratory and metastatic potential of tumor cells.

  2. Preparing Physics Ph.D. Students as Instructors

    Science.gov (United States)

    Manhart, Michael; Knapen, Simon

    2012-03-01

    As demand grows for education in STEM fields, there is an increasing need for Ph.D. physicists with a strong aptitude for and commitment to teaching. Development of these skills begins in graduate school, where most physicists are first exposed to teaching as TAs to undergraduate courses. The TA experience thus has considerable impact on the development of their teaching skills. Unfortunately, many graduate programs do not provide detailed training to their TAs. However, if departments hope to produce physicists who are also outstanding educators, they must create a culture of excellence in teaching that includes adequate training and incentives to excel for their graduate student TAs. As current Ph.D. students in the Department of Physics and Astronomy at Rutgers University, we have designed and implemented a TA training program to achieve these goals. Our program, Developing Educational Leaders among TAs in Physics (DELTA P), is aimed at new physics TAs and consists of an intensive orientation followed by 10 weekly seminars during the semester. The orientation focuses on the essential practical issues relevant to TAs before they first step in the classroom, while the seminars delve into more specialized topics, ranging from motivating non-majors to physics education research. Students who complete the program are given an official credential by the department to certify their training. After two years DELTA P has begun to effect positive changes to our department's TA experience, and we believe DELTA P serves as a useful model for other departments. In this talk, we will present our program and hope to engage in an interactive discussion with the audience about these issues.

  3. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  4. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... practitioner who lacks .'' Roy Chi Lung, 74 FR 20346, 20347 (2009); Scott Sandarg, D.M.D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez, M.D., 70 FR 33206, 33207 (2005); Stephen J. Graham, M.D., 69 FR 11661 (2004); Dominick A. Ricci, M.D., 58 FR 51104...

  5. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  6. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... intend administrative agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582... authority under the laws of the state in which he does business. See Scott Sandarg, D.M.D., 74 FR 17528 (DEA 2009); David W. Wang, M.D., 72 FR 54297 (DEA 2007); Sheran Arden Yeates, M.D., 71 FR 39130 (DEA...

  7. 76 FR 45867 - Michael S. Moore, M.D.; Suspension of Registration

    Science.gov (United States)

    2011-08-01

    ....S.A. 823 and 824. \\8\\ Indeed, in Alan H. Olefsky, 57 FR 928 (1992), DEA revoked a practitioner's... purposes of the CSA. Edson W. Redard, M.D., 65 FR 30616, 30618 (2000); Stanley Alan Azen, M.D., 61 FR 57893... (1997)); Redard, 65 FR at 30618; Stanley Alan Azen, M.D., 61 FR 57893, 57895 (1996). Agency...

  8. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  9. The Class of 1989 and post-MD training

    Science.gov (United States)

    Ryten, E; Thurber, A D; Buske, L

    1998-01-01

    BACKGROUND: "The Class of 1989" is a longitudinal study of 1722 people who were awarded an MD degree by a Canadian university in 1989. This paper reports on the details of their post-MD training up to spring 1996. METHODS: Several medical professional and educational associations in Canada and the United States provided year-by-year information on field and location of post-MD training, certification achieved, whether in practice and location of practice through to spring 1996. Information from all sources was linked to a list of 1989 medical school graduates. RESULTS: Of the 1722 graduates 57 (3.3%) never entered post-MD training in Canada; 147 (8.5%) did 1 or more years of training in the United States. A total of 222 graduates (12.9%) took a break of at least 1 year from training, and 301 (17.5%) changed their choice of field or specialty after starting training. Substantial numbers took 1 or more years longer to complete training than would be expected based on the prescribed length of the training program chosen. The field or specialty choices of the cohort produced a generalist:specialist ratio of 58:42. The final numbers in several fields depended heavily on trainees changing their initial career choice. INTERPRETATION: The data point out widely differing and often very long lead times from start to completion of training. Since 1993, changes to licensure requirements have reduced opportunities for recent graduating cohorts to delay final career choices, take a break in training, prolong training or change initial career choices. Rigidities in the post-1993 training environment point to the emergence of a number of serious problems, such as dissatisfaction and high anxiety levels among residents, licensing authorities being faced with people who have not completed a training program to certification, and insufficient provision of positions for post-MD training because of underestimates of the time needed to complete training programs. The insights gained

  10. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  11. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  12. SECURITY ANALYSIS ON MD5 AND ITS APPLICATION%MD5安全性分析及其应用

    Institute of Scientific and Technical Information of China (English)

    谭剑鸣; 徐建华; 汪崇华

    2002-01-01

    本文详细论述了MD5报文分解函数对文件签名的工作原理,剖析了MD5的安全性,针对具体的应用提出了使用MD5与RSA结合来解决数字签名的完整方案.文章的最后对MD5在PGP数字签名中的具体应用进行了分析讨论.

  13. Design and Implementation of MD5 with Salt%一种带随机数MD5算法的设计与实现

    Institute of Scientific and Technical Information of China (English)

    张丽香

    2013-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.MD5是HASH算法,常用来对重要数据的进行存储,本文对MD5算法进行了简要描述,介绍了MD5的破解方式,并对带随机数MD5算法进行了描述,采用PHP对算法的使用进行实现.

  14. Nano-scratch study of molecular deposition (MD) films on silicon wafer using nanoindentation~1

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Experiment of the molecular deposition (MD) films with and without alkyl terminal de-posited on the silicon wafer were conducted by using nanoindentation. It was found that MD filmsand alkyl terminated MD films exhibit higher critical load (scratch resistance or adhesive strength)and lower coefficient of friction compared with the silicon substrate. Critical load (scratch resis-tance) increases with the number of layers, and coefficients of friction of those MD film with alkylterminal are still best for the same layer of MD film.

  15. 改进MD5码增强网站密码安全性

    Institute of Scientific and Technical Information of China (English)

    张越; 陈跃; 刘林飞

    2009-01-01

    目的探讨改进MD5码,增强网络安全性.方法采用对用户密码进行加长、加强的二次加密,并对MD5码的算法进行修改,再使用MD5二次加密或多次加密.结果通过改进MD5码,用户密码安全性明显增强.结论改进MD5码,可以提高网站安全性.

  16. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Gang G.; Song, Jikui; Wang, Zhanxin; Dormann, Holger L.; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J.; Allis, C. David; (MSKCC); (Scripps); (Rockefeller)

    2009-07-21

    Histone H3 lysine4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  17. Edmund Burke, the Atlantic American war and the ‘poor Jews at St. Eustatius’. Empire and the law of nations

    Directory of Open Access Journals (Sweden)

    Guido Abbattista

    2008-01-01

    Full Text Available This essay is devoted to a relatively minor episode in Edmund Burke’s parliamentary career and political speculation involving the rights of war and international law in the final years of the American War of Independence. The starting point for Burke’s consideration of these questions was the affair of St. Eustatius, that is to say Britain’s conquest in 1781 of the Dutch West-Indian island early in the “fourth Anglo-Dutch War” of 1780-1784. The harsh treatment of the Dutch colony’s cosmopolitan community by the commanding officers of the British Navy and Army provoked a series of reactions in Britain and the colonies. The essay starts by outlining the identity of St. Eustatius with its economic, demographic and social features, its peculiar role in the eighteenth-century West Indies and its emblematic meaning in the historical literature of the Enlightenment as a symbol of the virtues of commerce and of economic liberty. It goes on to analyse the facts of the military conquest in 1781 and the ensuing occupation realized by Admiral George Rodney and Major-General John Vaughan, particularly as this affected the “poor Jews at St. Eustatius” (as Burke himself qualified them in his second speech on 4 December 1781, with the subsequent reactions of the Dutch and especially the British Atlantic world. We then examine Edmund Burke’s reasons for taking up this affair, including the political and ideological motives and the sources of arguments he used in the two parliamentary speeches he made on the topic during 1781, relating this to Burke’s ideas on international relations and imperial government during the 1770s and 1780s. We end by pointing to cultural links between Burke’s positions and a wider political, commercial and civic culture emerging in the British Atlantic world which reflected some of the most typical European Enlightenment values and ideological commitments.

  18. Regulated expression of the nifM of Azotobacter vinelandii in response to molybdenum and vanadium supplements in Burk's nitrogen-free growth medium.

    Science.gov (United States)

    Lei, S; Pulakat, L; Gavini, N

    1999-10-14

    Azotobacter is a diazotrophic bacterium that harbors three genetically distinct nitrogenases referred to as nif, vnf, and anf systems. The nifM is an accessory gene located in the nif gene cluster and is transcriptionally regulated by the NifA. However, Azotobacter mutants that lack NifA are known to synthesize functional NifM and this accessory protein is known to be needed for the activity of nitrogenase-2 and nitrogenase-3. To determine how the transcription of nifM is regulated when Azotobacter is grown under conditions in which nitrogenase-2 or nitrogenase-3 is expressed, we generated an Azotobacter vinelandii strain that carries a nifM:lacZ-kanamycin resistance gene cassette in its chromosome. In this strain the nifM open reading frame was disrupted by the presence of a lacZ-kanamycin resistance gene cassette so that it could not produce active NifM. Moreover, the lacZ gene was placed under the transcriptional control elements of the nifM gene so that the lacZ expression could be used as a marker to determine the extent of expression of the nifM gene under different growth conditions. Our results show that this strain was unable to grow in Burk's nitrogen-free medium supplemented with either molybdenum or vanadium or lacking both metals suggesting that in the absence of functional NifM none of the nitrogenases were active. It was also found that the nifM expression was differentially regulated when the A. vinelandii cells were grown under conditions that activate nitrogenase-2 and nitrogenase-3, as determined by liquid beta-galactosidase activity measurements. These results suggest that the transcriptional activators, VnfA and AnfA, may regulate the nifM expression. PMID:10527862

  19. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode;

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation...... evolutionary origin for the phd/doc operon. Doc induces growth arrest of Escherichia coli cells in a reversible manner, by targeting the protein synthesis machinery. Moreover, Doc activates the endogenous E. coli RelE mRNA interferase but does not require this or any other known chromosomal toxin...

  20. I-determinants for a successful PhD or postdoctoral outcome

    Directory of Open Access Journals (Sweden)

    Sørensen HT

    2016-08-01

    Full Text Available Henrik Toft Sørensen1–3 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark; 2Department of Health Research and Policy, 3Stanford’s Center for Advanced Study in Behavioral Sciences, Stanford University, Stanford, CA, USA Abstract: Many resources are invested in research training, but very little literature exists on predictors for a successful PhD and postdoctoral training outcome. A PhD program has two overall objectives: to extend knowledge about a hopefully important health topic and to provide extensive training to improve the PhD student’s skills through learning research methods and collaboration. A substantial number of PhD students may run into some kind of problem in the course of their PhD program. In this article, some determinants all starting with an “I” and indicative of a good PhD outcome are reported. The successful PhD student can be described as having an Interest in the PhD program, an Incentive for the program, and an Idea of what he or she wants to investigate, showing Initiative, and having high personal Integrity and good Interpersonal relationships. When these so-called I-determinants are present, the likelihood of success in a PhD program is high. More evidence is available for selection of candidates for postdoctoral appointments since it is known that the postdoctoral candidate has completed a PhD program, published papers in peer-reviewed journals, and received awarded grants. However, other characteristics determine a successful transition of the postdoctoral candidate into a research leader. These determinants are Identity, Independence and Image, Implementation ability in terms of being able to implement decisions and projects, working with Innovative and Important topics, having In-depth knowledge of the research topic, being Interactive and Integrated with the scientific community, and Internationally oriented. In conclusion, regardless of the framework of research, the

  1. Strategy formulation for the Phd Health Market (Pty) Ltd franchise group / Henk Heath

    OpenAIRE

    Heath, Henk

    2007-01-01

    Phd Health Market (Pty) Ltd was born from the vision of Anton Dupper and Advocate Jan Grobler, to turn a health store in Welkom, South Africa, into a national health franchise in the health & fitness industry. Phd Health Market has a vision to radically change society as a whole by changing nutritional eating and instilling a healthy lifestyle as a whole, which could be easily adapted by all. Phd Health Market is a small developing franchise group, requiring a much needed strategic plan in or...

  2. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  3. A Secure Hash Function MD-192 With Modified Message Expansion

    Directory of Open Access Journals (Sweden)

    Harshvardhan Tiwari

    2010-02-01

    Full Text Available Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  4. StandsSIM-MD: a Management Driven forest SIMulator

    Directory of Open Access Journals (Sweden)

    Susana Barreiro

    2016-07-01

    Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

  5. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  6. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  7. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  8. The Virtual Observatory Powered PhD Thesis

    Science.gov (United States)

    Zolotukhin, I. Yu.

    2010-12-01

    The Virtual Observatory has reached sufficient maturity for its routine scientific exploitation by astronomers. To prove this statement, here I present a brief description of the complete VO-powered PhD thesis entitled “Galactic and extragalactic research with modern surveys and the Virtual Observatory” comprising 4 science cases covering various aspects of astrophysical research. These comprize: (1) homogeneous search and measurement of main physical parameters of Galactic open star clusters in huge multi-band photometric surveys; (2) study of optical-to-NIR galaxy colors using a large homogeneous dataset including spectroscopy and photometry from SDSS and UKIDSS; (3) study of faint low-mass X-ray binary population in modern observational archives; (4) search for optical counterparts of unidentified X-ray objects with large positional uncertainties in the Galactic Plane. All these projects make heavy use of the VO technologies and tools and would not be achievable without them. So refereed papers published in the frame of this thesis can undoubtedly be added to the growing list of VO-based research works.

  9. The JIM interview. Art Levinson, PhD.

    Science.gov (United States)

    Levinson, A

    1997-06-01

    In the early 1980s several prominent scientists left the hallowed halls of respected universities seeking to exploit the revolution occurring in biology in an environment devoid of the bureaucratic and political confines of academia. The emergence of the biotechnology industry has been marked by both spectacular failures and success stories. Genentech was founded in 1976 by biochemist Herbert Boyer and venture capitalist Robert Swanson and went public in 1980. In 1995 Genentech merged with Roche Holdings Ltd., of Basel Switzerland. Distinguished from other biotech companies by the varied array of products it has brought to market, Genentech has also developed a unique corporate culture embodying many traditional academic values. Just as Genentech went public in 1980, Arthur D. Levinson, PhD, finished a post-doctoral appointment in Michael Bishop's lab at the University of California, San Francisco. Despite the disapproval of colleagues, he joined the fledgling company as a senior scientist. Working his way though the ranks, Levinson became Vice President of Research Technology in 1989 and was named President and CEO in 1995. Interviewed at the sprawling corporate headquarters in South San Francisco, Levinson reflected on the process of high risk science, the benefits of the private sector, and the changing relationship between biotech companies and the academic world.

  10. Trends in landscape research and landscape planning : implications for PhD students

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Antrop, M.

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  11. Role of PHD fingers and COOH-terminal 30 amino acids in AIRE transactivation activity.

    Science.gov (United States)

    Meloni, Alessandra; Incani, Federica; Corda, Denise; Cao, Antonio; Rosatelli, Maria Cristina

    2008-02-01

    Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomic autoimmune disease resulting from the defective function of a gene codifying for a transcription factor named autoimmune regulation (AIRE). The AIRE protein contains several domains among which two PHD fingers involved in the transcriptional activation. We investigated the function of the two PHD finger domains and the COOH terminal portion of AIRE by using several mutated constructs transfected in mammalian cells and a luciferase reporter assay. The results predict that the second PHD as well as the COOH terminal regions have marked transactivational properties. The COOH terminal region contains the fourth LXXLL and the PXXPXP motifs which play a critical role in mediating the transactivation capacity of the AIRE protein. Our study provides a definition of the role of the PHD fingers in transactivation and identifies a new transactivation domain of the AIRE protein localized in the COOH terminal region.

  12. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  13. PhD Wang Xingchu,A Successful Leader of A High-tech Company Reform

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ PhD Wang Xingchu was born in 1962. He is the Board Chairman of Shanghai Biotechnology Industrial Garden Coalition Development Co., Ltd. and the General Manager of Shanghai Hua Xin High-Biotechnology Co., Ltd.

  14. Improved Bearings-Only Multi-Target Tracking with GM-PHD Filtering

    Science.gov (United States)

    Zhang, Qian; Song, Taek Lyul

    2016-01-01

    In this paper, an improved nonlinear Gaussian mixture probability hypothesis density (GM-PHD) filter is proposed to address bearings-only measurements in multi-target tracking. The proposed method, called the Gaussian mixture measurements-probability hypothesis density (GMM-PHD) filter, not only approximates the posterior intensity using a Gaussian mixture, but also models the likelihood function with a Gaussian mixture instead of a single Gaussian distribution. Besides, the target birth model of the GMM-PHD filter is assumed to be partially uniform instead of a Gaussian mixture. Simulation results show that the proposed filter outperforms the GM-PHD filter embedded with the extended Kalman filter (EKF) and the unscented Kalman filter (UKF). PMID:27626423

  15. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are s

  16. Report on the International PhD School ''Science and Technology with the E-ELT''

    Science.gov (United States)

    Bono, G.; Hook, I.; Ramsay, S.

    2015-12-01

    This international PhD school in the F. Lucchin cycle was the first to bring together Masters and PhD students with an interest in all aspects of the science and technology of the European Extremely Large Telescope (E-ELT). It was fitting that this school was held within a year of the project formally entering the construction phase. An overview of the topics covered during the school is presented.

  17. Graduate and Ph.D. Course on Design and Manufacture of Micro Mechanical Systems

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; De Grave, Arnaud

    2011-01-01

    at the Department of Mechanical Engineering at the Technical University of Denmark. This paper describes the framework of the course that has been applied both at graduate and Ph.D. level. The current structure of the course as well as the pedagogical approach and some examples of final projects will be presented....... Moreover, the transformation of the traditional semester structure (13 weeks and 3 weeks project) into a 2 weeks PhD summer school is discussed....

  18. PhD Seminar within the framework of Water Doctoral Network of Engineering and Management

    OpenAIRE

    Kluska, Andreas; Stefan, Catalin

    2013-01-01

    The Water Doctoral Network of Engineering and Management is a bilateral German – Vietnamese academic network with the aim to provide a platform for the development of joint research activities in water sector. Within the framework of the project, the network members organised a series of workshops and seminars targeted especially at PhD students from universities conducting research programs in water-related issues from both countries. The present paper summarises the outcomes of the last PhD...

  19. MS PHD'S: Effective Strategies for the Retention and Advancement of URM Students in ESS

    Science.gov (United States)

    Escalera, J.; Burgess, A. K.; Pace, L.; Scott, O.; Strickland, J.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.

    2012-12-01

    The Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) Professional Development Program in Earth system science (ESS) is a model initiative for improving the retention of underrepresented minority (URM) students in STEM fields. Entering its ninth cohort, MS PHD'S remains committed to helping URM undergraduate and graduate students achieve outstanding careers in ESS. MS PHD'S facilitates URM student achievement through a three-phase program designed to increase student exposure to the ESS community. By engaging in a series of professional development and skill building exercises, peer-to-peer community building activities, participation in scientific society conferences and workshops, mentoring by URM and other scientists, and a virtual community, URM students gain the confidence and support necessary to achieve their academic goals and enter the ESS workforce. Since its inception, MS PHD'S continues to support 189 participants. Of these 189 participants, 35 have advanced from undergraduate and graduate academic pathways to completion of their PhD and another 60 are currently enrolled in doctoral programs. MS PHD'S maintains close ties with program alumni to further support retention, inclusivity, and broadening participation of URM students and graduates in STEM activities. Its model is built on reengaging alumni to become mentors and leaders for each new cohort as well as facilitating valuable opportunities for alumni to advance in their ESS related academic and professional career pathways.

  20. Solution NMR structure and histone binding of the PHD domain of human MLL5.

    Directory of Open Access Journals (Sweden)

    Alexander Lemak

    Full Text Available Mixed Lineage Leukemia 5 (MLL5 is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. In addition to its catalytic domain, MLL5 contains a PHD finger domain, a protein module that is often involved in binding to the N-terminus of histone H3. Here we report the NMR solution structure of the MLL5 PHD domain showing a variant of the canonical PHD fold that combines conserved H3 binding features from several classes of other PHD domains (including an aromatic cage along with a novel C-terminal α-helix, not previously seen. We further demonstrate that the PHD domain binds with similar affinity to histone H3 tail peptides di- and tri-methylated at lysine 4 (H3K4me2 and H3K4me3, the former being the putative product of the MLL5 catalytic reaction. This work establishes the PHD domain of MLL5 as a bone fide 'reader' domain of H3K4 methyl marks suggesting that it may guide the spreading or further methylation of this site on chromatin.

  1. PHD2在宫颈病变中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    朱诚程; 周家德; 倪观太; 孙恒亮

    2014-01-01

    目的:研究不同宫颈组织中脯氨酸羟化酶2( PHD2)的表达情况,初步探讨PHD2在宫颈病变中的作用和意义。方法:选取正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌标本各20例,应用逆转录多聚酶链反应( RT-PCR)、免疫组化法( SP法)检测PHD2 mR-NA和蛋白水平的相对表达情况。结果:正常宫颈、CINⅠ和CINⅡ、CINⅢ、宫颈癌组织中,PHD2蛋白和mRNA表达水平依次上调,两两比较差异均有统计学意义(P<0.01)。结论:PHD2可能参与宫颈病变的发生发展,作为肿瘤标记物用于早期诊断和预后判断。下调PHD2的高表达,可能成为治疗宫颈癌的新靶点。

  2. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  3. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  4. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  5. MD5碰撞攻击的差分路径构建%Constructing Differential Path in MD5 Collision Attack

    Institute of Scientific and Technical Information of China (English)

    刘凡保; 谢涛

    2009-01-01

    著名的杂凑算法MD5是MD4的增强版本,由Ronald L.Rivest在1991年设计.MD5广泛应用于口令变换、数据完整性、数字证书等领域.近年最具影响的MD5安全性的分析结果是王小云首次发现的MD5碰撞.之后,MD5碰撞攻击的改进主要集中在提高碰撞对搜索的性能.基于新的不同于王小云的明文差分构成的MD5碰撞,介绍差分路径的构建方法,并给出一条差分路径以及碰撞对数据.

  6. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  7. Preparing for Graduate-Level Training in Professional Psychology: Comparisons across Clinical PhD, Counseling PhD, and Clinical PsyD Programs

    Science.gov (United States)

    Karazsia, Bryan T.; Smith, Lena

    2016-01-01

    In the present study, faculty who teach in clinical and counseling doctor of philosophy (PhD) or doctor of psychology (PsyD) programs completed surveys regarding preferences for prospective student preparations to graduate programs. Faculty expectations of minimum and ideal undergraduate training were highest for scientific methods, though…

  8. Professional Socialization for the Ph.D.: An Exploration of Career and Professional Development Preparedness and Readiness for Ph.D. Candidates

    Science.gov (United States)

    Helm, Matt; Campa, Henry, III; Moretto, Kristin

    2012-01-01

    This study sought to uncover the career readiness and professional development needs of Ph.D. students at a large, Midwestern research university. Findings indicate that career goals of graduate students change over time, skill preparation for academic and non-academic careers continues to be inadequate for many students and professional…

  9. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  10. The MD5 Technical Analysis and Improvement Measures%MD5技术解析及改进措施

    Institute of Scientific and Technical Information of China (English)

    窦立莉

    2010-01-01

    随着网络的迅速普及,信息加密技术的发展对保障网络安全有着重大的作用与意义.本文对MD5 这种单向加密算法进行了简要描述,对MD5 算法的原理进行了深入分析,并提出了MD5 码的多种改进措施.

  11. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  12. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  13. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  14. QM/MM-MD simulations of conjugated polyelectrolytes

    DEFF Research Database (Denmark)

    Sjöqvist, Jonas; Linares, Mathieu; Mikkelsen, Kurt Valentin;

    2014-01-01

    A methodological development is reported for the study of luminescence properties of conjugated polyelectrolytes, encompassing systems in which dihedral rotational barriers are easily overcome at room temperature. The components of the model include (i) a molecular mechanics (MM) force field...... description of the solvent in its electronic ground state as well as the chromophore in its electronic ground and excited states, (ii) a conformational sampling by means of classical molecular dynamics (MD) in the respective electronic states, and (iii) spectral response calculations by means of the quantum....... In fluorescence spectroscopy, the experimental spectrum shows a vibrational progression that is not addressed by theory, but the theoretical band position is in excellent agreement with experiment, with a highly accurate description of the Stokes shift as a result....

  15. RADIATION PRESSURE DETECTION AND DENSITY ESTIMATE FOR 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T., E-mail: micheli@ifa.hawaii.edu, E-mail: tholen@ifa.hawaii.edu, E-mail: gte@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2014-06-10

    We present our astrometric observations of the small near-Earth object 2011 MD (H ∼ 28.0), obtained after its very close fly-by to Earth in 2011 June. Our set of observations extends the observational arc to 73 days, and, together with the published astrometry obtained around the Earth fly-by, allows a direct detection of the effect of radiation pressure on the object, with a confidence of 5σ. The detection can be used to put constraints on the density of the object, pointing to either an unexpectedly low value of ρ=(640±330)kg m{sup −3} (68% confidence interval) if we assume a typical probability distribution for the unknown albedo, or to an unusually high reflectivity of its surface. This result may have important implications both in terms of impact hazard from small objects and in light of a possible retrieval of this target.

  16. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  17. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  18. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  19. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  20. Política, religião, revolução e soberania em Reflexões sobre a revolução em França do conservador E. Burke

    Directory of Open Access Journals (Sweden)

    Raquel Kritsch

    2011-08-01

    Full Text Available

    O objetivo deste artigo é introduzir ao leitor o pensamento político de Edmund Burke, um dos nomes mais influentes do pensamento político conservador. A partir de uma breve contextualização da crítica burkeana ao racionalismo iluminista, o artigo procura mostrar como o autor organiza conceitos centrais de sua teoria política, como poder, legitimidade, conservação, correção, preconceito, prescrição, num discurso articulado e coerente, com o objetivo de sustentar que na Inglaterra política e religião constituem, juntas, não só a base não só da prosperidade do povo mas também o fundamento do Estado. Em seguida, aborda-se a crítica de Burke à Revolução Francesa, à “psicologia dos revolucionários” e, de maneira mais detida, aos direitos do homem, discutindo alguns de seus argumentos contra as abstrações distanciadas das práticas concretas dos coletivos humanos e a transformação da metafísica moderna num programa político.

  1. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  2. On the Importance of PhD Institute in Establishing a Long-Term Research Career in Astronomy

    OpenAIRE

    Gibson, Brad K.; Buxton, Michelle; Vassiliadis, Emanuel; Sevenster, Maartje N.; Jones, D. Heath; Thornberry, Rebecca K.

    1999-01-01

    We have examined the success rates of 19 American, Canadian, Australian, and Dutch graduate programs in producing astronomers. A 20-year baseline was considered (1975-1994), incorporating 897 PhD recipients. The major conclusion from our study is that the fraction of PhD graduates still involved in astronomical research is surprisingly insensitive to the institutional source of one's PhD. With few exception, 55-75% of graduates, regardless of PhD source, remain active in the astronomical rese...

  3. Was it worth it? An empirical analysis of over-education among Ph.D. recipients in Italy

    OpenAIRE

    Giuseppe Lucio Gaeta

    2013-01-01

    This paper aims to provide an empirical examination of factors associated with overeducation among Ph.D. graduates in Italy. Our investigation is based on recently released data collected by the Italian National Institute of Statistics by means of interviews with a large sample of Ph.D. recipients, carried out a few years after they obtained their Ph.D. degree. We measured the mismatch between their current job and previous Ph.D. studies using two direct subjective evaluations of over-educati...

  4. Interoperability in digital electrocardiography: harmonization of ISO/IEEE x73-PHD and SCP-ECG.

    Science.gov (United States)

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Serrano, Luis; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2010-11-01

    The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard for short-term diagnostic ECGs (EN1064:2005+A1:2007) has recently been approved as part of the x73 family (ISO 11073-91064:2009). These factors suggest the coordinated use of these two standards in foreseeable telecardiology environments, and hence the need to harmonize them. Such harmonization is the subject of this paper. Thus, a mapping of the mandatory attributes defined in the second draft of the ISO/IEEE 11073-10406-d02 and the minimum SCP-ECG fields is presented, and various other capabilities of the SCP-ECG Standard (such as the messaging part) are also analyzed from an x73-PHD point of view. As a result, this paper addresses and analyzes the implications of some inconsistencies in the coordinated use of these two standards. Finally, a proof-of-concept implementation of the draft x73-PHD ECG device specialization is presented, along with the conversion from x73-PHD to SCP-ECG. This paper, therefore, provides recommendations for future implementations of telecardiology systems that are compliant with both x73-PHD and SCP-ECG.

  5. MS PHD'S: A Synergistic Model for Diversifying the Earth Science Community

    Science.gov (United States)

    Ricciardi, L.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.; Braxton, L.; Johnson, A.

    2013-05-01

    The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) program focuses on increasing the number of underrepresented minorities (URM) receiving advanced degrees in Earth system sciences (ESS). Subscribing to Aristotle's philosophy that the "whole is greater than the sum of its parts", MS PHD'S uses a synergistic model of tiered mentoring practices, successful minority scientist role models, peer-to-peer community building activities, professional development training techniques, networking opportunities, and state of the art virtual communication tools to facilitate the retention and advancement of underrepresented ESS scientists. Using a three-phase program structure supported by a virtual community, URM students in ESS are afforded opportunities to establish mentoring relationships with successful scientists, build meaningful ties with URM peers and future colleagues, strengthen oral and written communication skills, engage in networking opportunities within premier scientific venues, and maintain continuity of networks formed through program participation. Established in 2003, MS PHD'S is now in its ninth cohort. From the original cohort of 24 participants, the program has grown to support 213 participants. Of these 213 participants, 42 have obtained the doctorate and are employed within the ESS workforce. Another 71 are enrolled in doctoral programs. Looking to the future with the purpose of continually furthering its synergistic philosophy, MS PHD'S has developed a new initiative, Beyond the PhD, designed to support and advance the representation of URM scientists within a global workforce.

  6. Preparing Postbaccalaureates for Entry and Success in Biomedical PhD Programs.

    Science.gov (United States)

    Hall, Joshua D; Harrell, Jessica R; Cohen, Kimberley W; Miller, Virginia L; Phelps, Patricia V; Cook, Jeanette G

    2016-01-01

    Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an intensive, 1-yr postbaccalaureate training program. We hypothesized that this intervention would strengthen each participant's competitiveness for leading PhD programs and build a foundation of skills and self-efficacy important for success during and after graduate school. Scholar critical analysis skills, lab technique knowledge, and Graduate Record Examination scores all improved significantly during the program. Scholars reported significant confidence growth in 21 of 24 categories related to success in research careers. In 5 yr, 91% (41/45) of scholars transitioned directly into PhD programs. Importantly, 40% (18/45) of participating postbaccalaureate scholars had previously been declined acceptance into graduate school; however, 17/18 of these scholars directly entered competitive PhD programs following our training program. Alumni reported they were "extremely well" prepared for graduate school, and 95% (39/41) are currently making progress to graduation with a PhD. In conclusion, we report a model for postbaccalaureate training that could be replicated to increase participation and success among UR scholars in the biomedical sciences. PMID:27496358

  7. PhD students’ expectations from their supervisors: A qualitative content analysis

    Directory of Open Access Journals (Sweden)

    SH Rimaz

    2015-03-01

    Full Text Available Introduction: Quality of research in PhD programs increases if supervisors become aware of students' expectations from them. This qualitative study aimed to explore expectations of PhD students from their supervisors was done.   Methods: This qualitative content analysis study was conducted on 22 graduated PhD students of Iran University of Medical Sciences, in 2014. The samples were purposefully selected and interviewed. All interviews were recorded and transcribed verbatim.   Results: After analyzing and coding data, it was found that PhD students have four main expectations from their supervisors. These expectations consist of scientific support including help with selection of subject, preparation and registration of proposal, data collection and support for writing and examination of the thesis. Developing scientific skills and help with preparing manuscripts were other expectations. Emotional-social support with five categories including relationship between supervisor-student, general expectations of supervisor, supervisor personality characteristics, needed emotional skills and social activities related to thesis and finally providing adequate resources including financial support and access to facilities inside and outside the university were among the other expectations.   Conclusion: PhD students need to scientific, emotional, social and material supports from their supervisors in the process of performing thesis. These expectations should be told to supervisors.

  8. Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

    Energy Technology Data Exchange (ETDEWEB)

    McDonough,M.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.; Zondlo, J.; Oldham, N.; Clifton, I.; et al.

    2006-01-01

    Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-{alpha} subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to chronic hypoxia; the PHDs thus act as an oxygen-sensing component of the HIF system, and their inhibition mimics the hypoxic response. We describe crystal structures of the catalytic domain of human PHD2, an important prolyl-4-hydroxylase in the human hypoxic response in normal cells, in complex with Fe(II) and an inhibitor to 1.7 Angstroms resolution. PHD2 crystallizes as a homotrimer and contains a double-stranded {beta}-helix core fold common to the Fe(II) and 2-oxoglutarate-dependant dioxygenase family, the residues of which are well conserved in the three human PHD enzymes (PHD 1-3). The structure provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.

  9. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  10. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  11. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  12. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  13. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  14. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... produced a letter from Vella V. Chancellor, M.D., the Chair of the Physician's Recovery Committee of the Dallas County Medical Society. RX 11. Dr. Chancellor wrote that Respondent ``has been actively seeing...

  15. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  16. 76 FR 50950 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Science.gov (United States)

    2011-08-17

    ... (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The... of Wight (Sinepuxent) Bay, mile 0.5, at Ocean City, MD. The proposed change will alter the dates the... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed...

  17. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  18. Publication rate and PhD enrolment following a medical pre-graduate research programme

    DEFF Research Database (Denmark)

    Skovgaard, Marlene; Okkels, Niels; Christensen, Mette Krogh;

    2015-01-01

    a PGRP compared to female medical students (28% versus 19%; p research students had enrolled in a PhD programme at Health, and 52% had published ≥ 1 paper with ≥ 1 supervisor. The research student was the first author on 43......INTRODUCTION: In the 1990s, the publication and PhD recruitment rates following the Danish pre-graduate research programme (PGRP) in medicine were 54% and 33%, respectively. Updated estimates are unknown. METHODS: All medical students enrolled in the PGRP at the Faculty of Medicine, Aarhus...... University (Health), Denmark, during 2003-2012 were included (n = 687). The PGRP files were merged with PhD students' files at Health. A systematic literature search was completed for research students who had enrolled during the 2006-2009 period (n = 227). The factors investigated were student age, sex...

  19. H5MD: a structured, efficient, and portable file format for molecular data

    CERN Document Server

    de Buyl, Pierre; Höfling, Felix

    2013-01-01

    We propose a new open file format named "H5MD" for storing molecular simulation data such as trajectories of particle positions and velocities as well as thermodynamic observables that are tracked during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional data sets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data without breaking the compliance of the file to the specification.

  20. H5MD: A structured, efficient, and portable file format for molecular data

    Science.gov (United States)

    de Buyl, Pierre; Colberg, Peter H.; Höfling, Felix

    2014-06-01

    We propose a new file format named "H5MD" for storing molecular simulation data, such as trajectories of particle positions and velocities, along with thermodynamic observables that are monitored during the course of the simulation. H5MD files are HDF5 (Hierarchical Data Format) files with a specific hierarchy and naming scheme. Thus, H5MD inherits many benefits of HDF5, e.g., structured layout of multi-dimensional datasets, data compression, fast and parallel I/O, and portability across many programming languages and hardware platforms. H5MD files are self-contained, and foster the reproducibility of scientific data and the interchange of data between researchers using different simulation programs and analysis software. In addition, the H5MD specification can serve for other kinds of data (e.g. experimental data) and is extensible to supplemental data, or may be part of an enclosing file structure.

  1. PHP中的MD5加密机制探究

    Institute of Scientific and Technical Information of China (English)

    党长青

    2014-01-01

    MD5广泛用于加密和解密技术上。现阶段,存在两种加密方式,双向加密和单向加密。MD5是在Web应用程序中最常用的密码加密算法。由于MD5是不可逆的,因而经过MD5计算得到后的密文,不能通过逆向算法得到原文。在PHP应用程序中使用MD5加密文本密码的初衷,就是为了防止数据库中保存的密码不幸泄露后被直接获得。

  2. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  3. Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

    Science.gov (United States)

    Mattis, Daiva M; Chervin, Adam S; Ranoa, Diana R; Kelley, Stacy L; Tapping, Richard I; Kranz, David M

    2015-12-01

    Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary complex, TLR4:MD-2:LPS. With the goal of further understanding the molecular details of the interaction of MD-2 with LPS and TLR4, and possibly toward engineering dominant negative regulators of the MD-2 protein, here we subjected MD-2 to a mutational analysis using yeast display. The approach included generation of site-directed alanine mutants, and ligand-driven selections of MD-2 mutant libraries. Our findings showed that: (1) proline mutations in the F119-K132 loop that binds LPS were strongly selected for enhanced yeast surface stability, (2) there was a preference for positive-charged side chains (R/K) at residue 120 for LPS binding, and negative-charged side chains (D/E) for TLR4 binding, (3) aromatic residues were strongly preferred at F119 and F121 for LPS binding, and (4) an MD-2 mutant (T84N/D101A/S118A/S120D/K122P) exhibited increased binding to TLR4 but decreased binding to LPS. These studies revealed the impact of specific residues and regions of MD-2 on the binding of LPS and TLR4, and they provide a framework for further directed evolution of the MD-2 protein. PMID:26320630

  4. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish.

    Science.gov (United States)

    Candel, Sergio; Sepulcre, María P; Espín-Palazón, Raquel; Tyrkalska, Sylwia D; de Oliveira, Sofía; Meseguer, José; Mulero, Victoriano

    2015-06-01

    TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to form complexes that directly interact with the MD2-TLR4 complex, acting as physiological negative regulators of LPS signaling. Despite the general conservation of various TLR families from fish to mammals, several differences can be appreciated, such as the high tolerance of fish to LPS, the absence of the crucial accessory molecules Md2 and Cd14 for Tlr4 signaling in fish, the absence of Tlr4 in some fish species, and the confirmation that LPS does not signal through Tlr4 in zebrafish. The present study has identified the Rp105 and Md1 homologs in zebrafish, confirming (i) Rp105 and Tlr4 evolved from a common ancestor before the divergence between fish and tetrapods and (ii) the presence of Md1 in teleost fish and the lack of Md2, suggesting that the divergence of these accessory molecules occurred in the tetrapod lineage. Biochemical and functional studies indicate that Md1 binds both Rp105 and Tlr4 in zebrafish. Genetic inhibition of zebrafish Md1 and Rp105 reveals that Md1 or Rp105 deficiency impairs the expression of genes encoding pro-inflammatory and antiviral molecules, leading to increased susceptibility to viral infection. These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity.

  5. AHA scientific statement: Summary of the scientific conference on dietary fatty acids and cardiovascular health

    NARCIS (Netherlands)

    Kris-Etherton, P.; Daniels, S.R.; Eckel, R.H.; Engler, M.; Howard, B.V.; Krauss, R.M.; Lichtenstein, A.H.; Sacks, F.; St. Jeor, S.; Stampfer, M.; Grundy, S.M.; Zock, P.L.

    2001-01-01

    Conference Planning and Writing Committee:Penny Kris-Etherton, PhD, Stephen R. Daniels, MD, PhD, Robert H. Eckel, MD, Marguerite Engler, PhD, RN, Barbara V. Howard, PhD, Ronald M. Krauss, MD, Alice H. Lichtenstein, DSc, Frank Sacks, MD, Sachiko St. Jeor, PhD, Meir Stampfer, MD, DrPH, For the America

  6. The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

    Institute of Scientific and Technical Information of China (English)

    Nan Chen; Oliver Rinner; Dominika Czernik; Katarzyna J Nytko; Dan Zheng; Daniel P Stiehl; Nicola Zamboni; Matthias Gstaiger; Christian Frei

    2011-01-01

    @@ Dear Editor, Oxygen levels are critical for cellular physiology.Under low oxygen (hypoxia),cells increase glycolysis while limiting mitochondrial oxidative metabolism.Such adaptation is largely mediated by the transcription factors HIF,which accumulate under hypoxia [1,2].Prolyl hydroxylase domain proteins (PHD) function as cellular oxygen sensors and target HIF for subsequent degradation under normoxia [2].The PHD/HIF pathway is conserved in Drosophila,where a single prolyl hydroxylase,Fatiga,has been characterized.We have previously reported that Fatiga regulates cellular growth rates in a HIF-independent manner,yet mechanisms remained elusive [3].

  7. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twenty...... engineering profilies:(1) Engineeing Design and Product Development and (2)Control Engineering which give possibilitie for specialisation in fluid power and mechatronics design and productdevelopment. Synthesis, design and self-learning competency have a high priority taking the importance of training...

  8. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    1997-01-01

    It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving the commun...... the communication and cooperation between them. In a year of the PhDOOS network the workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information on the PhDOOS network can be found at http://purl.org/net/PhDOOS....

  9. Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice

    Science.gov (United States)

    Cheng, Shaohong; Aghajanian, Patrick; Pourteymoor, Sheila; Alarcon, Catrina; Mohan, Subburaman

    2016-01-01

    Endochondral ossification plays an important role in the formation of the primary ossification centers (POCs) and secondary ossification centers (SOCs) of mammalian long bones. However, the molecular mechanisms that regulate POC and SOC formation are different. We recently demonstrated that Prolyl Hydroxylase Domain-containing Protein 2 (Phd2) is a key mediator of vitamin C effects on bone. We investigated the role of Phd2 on endochondral ossification of the epiphyses by conditionally deleting the Phd2 gene in osteoblasts and chondrocytes. We found that the deletion of Phd2 in osteoblasts did not cause changes in bone parameters in the proximal tibial epiphyses in 5 week old mice. In contrast, deletion of Phd2 in chondrocytes resulted in increased bone mass and bone formation rate (normalized to tissue volume) in long bone epiphyses, indicating that Phd2 expressed in chondrocytes, but not osteoblasts, negatively regulates secondary ossification of epiphyses. Phd2 deletion in chondrocytes elevated mRNA expression of hypoxia-inducible factor (HIF) signaling molecules including Hif-1α, Hif-2α, Vegfa, Vegfb, and Epo, as well as markers for chondrocyte hypertrophy and mineralization such as Col10, osterix, alkaline phosphatase, and bone sialoprotein. These data suggest that Phd2 expressed in chondrocytes inhibits endochondral ossification at the epiphysis by suppressing HIF signaling pathways. PMID:27775044

  10. Publishing and Learning Writing for Publication in English: Perspectives of NNES PhD Students in Science

    Science.gov (United States)

    Huang, Ju Chuan

    2010-01-01

    Publication in international journals has become a prerequisite to PhD graduation. This study thus provides a framework for understanding the learning of writing skills and publishing practices of nonnative English-speaking PhD students by investigating their perceptions of publishing and learning to write for publication. Findings show that these…

  11. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  12. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  13. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  14. Electroporation of archaeal lipid membranes using MD simulations.

    Science.gov (United States)

    Polak, Andraž; Tarek, Mounir; Tomšič, Matija; Valant, Janez; Ulrih, Nataša Poklar; Jamnik, Andrej; Kramar, Peter; Miklavčič, Damijan

    2014-12-01

    Molecular dynamics (MD) simulations were used to investigate the electroporation of archaeal lipid bilayers when subjected to high transmembrane voltages induced by a charge imbalance, mimicking therefore millisecond electric pulse experiments. The structural characteristics of the bilayer, a 9:91 mol% 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-myo-inositol (AI) and 2,3-di-O-sesterterpanyl-sn-glicerol-1-phospho-1'(2'-O-α-D-glucosyl)-myo-inositol (AGI) were compared to small angle X-ray scattering data. A rather good agreement of the electron density profiles at temperatures of 298 and 343 K was found assessing therefore the validity of the protocols and force fields used in simulations. Compared to dipalmitoyl-phosphatidylcholine (DPPC), the electroporation threshold for the bilayer was found to increase from ~2 V to 4.3 V at 323 K, and to 5.2 V at 298 K. Comparing the electroporation thresholds of the archaeal lipids to those of simple diphytanoyl-phosphatidylcholine (DPhPC) bilayers (2.5 V at 323 K) allowed one to trace back the stability of the membranes to the structure of their lipid head groups. Addition of DPPC in amounts of 50 mol% to the archaeal lipid bilayers decreases their stability and lowers the electroporation thresholds to 3.8 V and 4.1 V at respectively 323 and 298 K. The present study therefore shows how membrane compositions can be selected to cover a wide range of responses to electric stimuli. This provides new routes for the design of liposomes that can be efficiently used as drug delivery carriers, as the selection of their composition allows one to tune in their electroporation threshold for subsequent release of their load.

  15. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  16. Ph.D. Thesis: Quantum Field Theory and Gravity in Causal Sets

    CERN Document Server

    Sverdlov, Roman

    2009-01-01

    This is is a copy of dissertation that I have submitted in defense of my ph.d. thesis, with some minor changes that I have made since then. The goal of the project is to generalize matter fields and their Lagrangians from regular space time to causal sets.

  17. Ph.D. Thesis: Quantum Field Theory and Gravity in Causal Sets

    Science.gov (United States)

    Sverdlov, Roman

    2009-05-01

    This is is a copy of dissertation that I have submitted in defense of my ph.d. thesis, with some minor changes that I have made since then. The goal of the project is to generalize matter fields and their Lagrangians from regular space time to causal sets.

  18. Winning the PhD Game: Evocative Playing of Snakes and Ladders

    Science.gov (United States)

    Dickie, Carolyn

    2011-01-01

    The purpose of this paper is to describe a qualitative approach to developing an understanding of the lived experiences of PhD students. Rather than relying on textbook reports and theories about studying a higher degree by research, by allowing the students' voices to be heard, explicit and conscious research can be used to generate appropriate…

  19. Completing a PhD by Publication: A Review of Australian Policy and Implications for Practice

    Science.gov (United States)

    Jackson, Denise

    2013-01-01

    There is increasing impetus for higher-degree-by-research students to publish during candidature. Research performance, including higher degree completions and publication output, commonly determines university funding, and doctorates with publishing experience are better positioned for a career in softening academic labour markets. The PhD by…

  20. Content of Variable-scale Maps: PhD Research Proposal

    NARCIS (Netherlands)

    Šuba, R.

    2013-01-01

    This PhD research proposal focuses on vario-scale geo-information. Vario-scale is a new approach for creating maps o_ering an infinitely number of scales, minimum redundancy and a data structure for progressive transfer. A lot of knowledge has to be implemented in the generalization process to popul

  1. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  2. International Students' Motivation to Pursue and Complete a Ph.D. in the U.S.

    Science.gov (United States)

    Zhou, Ji

    2015-01-01

    This study explores what motivates 19 international students to pursue a Ph.D. at a public research university in the U.S. and, more importantly, what motivates them to persist despite unsatisfying socialization. Based on value-expectancy achievement motivation theory, four motivations emerged: intrinsic interest in research, intrinsic interest in…

  3. Career-Self Management and Entrepreneurship: An Experience with PhD Students

    Science.gov (United States)

    Pinto, Joana Carneiro; do Ceu Taveira, Maria; Sa, Elisabete

    2012-01-01

    Introduction: This study presents an experience developed with PhD students aimed to analyze the extent to which career self-management should be approached along with entrepreneurship issues to promote students' career development. Method: An intervention group who attended a Career Self-Management Seminar (EG1), a comparison group who attended…

  4. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts presented illustrate…

  5. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  6. The Impact of Publishing during PhD Studies on Career Research Publication, Visibility, and Collaborations

    Science.gov (United States)

    Horta, Hugo; Santos, João M.

    2016-01-01

    This study analyzes the impact that publishing during the period of PhD study has on researchers' future knowledge production, impact, and co-authorship. The analysis is based on a representative sample of PhDs from all fields of science working in Portugal. For each researcher in the dataset, we compiled a lifetime publication record and…

  7. PhD versus DSW: A Critique of Trends in Social Work Doctoral Education

    Science.gov (United States)

    Howard, Tyriesa

    2016-01-01

    Social work educators are in a phase of reintroducing the doctor of social work (DSW) degree and refining distinctions between PhD and DSW doctoral programs. This article examines how the two options have been prey to a noticeable "seesaw of precedence", resulting in a debatable history of social work's approach to doctoral education…

  8. Imaginaries of "Europe" in the Governmentality of PhD Education

    Science.gov (United States)

    Bergviken Rensfeldt, Annika

    2014-01-01

    This article examines the recent European governing of PhD education by describing and destabilizing how Europe, as a social construct, is inscribed in the governing in multiple ways. Conceptually, it aligns with post-Foucauldian research interests in imaginaries of societies, subjectivities, and politics of knowledge. Based on European policies…

  9. The Focus and Substance of Formative Comment Provided by PhD Examiners

    Science.gov (United States)

    Holbrook, Allyson; Bourke, Sid; Fairbairn, Hedy; Lovat, Terence

    2014-01-01

    In practice and process PhD examination is distinctive, reflecting the high expectations of students whose learning has been directed to their becoming researchers. This article builds on previous research on the examination of Australian theses that revealed that examiners in Science (n?=?542) and Education (n?=?241) provide a substantial…

  10. Re-Envisioning the Arts PhD: Intellectual Entrepreneurship and the Intellectual Arts Leader

    Science.gov (United States)

    Cherwitz, Richard A.; Beckman, Gary D.

    2006-01-01

    The authors of this article contend that most doctoral students in the arts do not fully appreciate the meaning of their PhD, and that the current system of graduate education perpetuates this phenomenon, with each generation of professors passing down their understanding of the doctorate to succeeding generations. The authors argue that what is…

  11. Career Aspirations and Career Outcomes for Solar and Space Physics Ph.D

    Science.gov (United States)

    Moldwin, M.; Morrow, C. A.

    2013-12-01

    Results from a recent graduate student survey found unsurprisingly that Solar and Space Physics (S&SP) Ph.D. graduate students almost all aspire to have research careers in Solar and Space Physics. This study reports on the research career outcomes over the last decade for S&SP Ph.Ds. We used publication of peer-reviewed articles as the indicator for persistence in a research career. We found that nearly two-thirds (64%) of Ph.D.s who graduated between 2001 to 2009 published refereed-papers four or more years after their Ph.D., while 17% of Ph.D.s never published another paper beyond the year they received their Ph.D. The remaining 19% of Ph.Ds, stopped publishing within three-years of receiving their Ph.D. We found that though there is statistically no difference on persistence of publishing research between graduates of the largest programs compared to all other programs, there are significant differences between programs. We also found there was no gender differences in any of the persistence data (i.e., men and women stop or continue publishing at the same rates). Graduate programs, faculty advisors and potential graduate students can use these data for career planning. This study suggests that a significant majority of S&SP Ph.D.s (77%) find post-doctoral research positions and a majority (56%) find research careers beyond their post-doc.

  12. 9th Workshop for PhD Students in Object Oriented Systems

    NARCIS (Netherlands)

    Rashid, Awais; Parsons, David; Telea, Alexandru

    1999-01-01

    The PhDOOS workshop covered a wide scope, as its over 20 participants were PhD students in all areas of object orientation. The presentations covered topics such as databases, languages, software engineering and artificial intelligence, components and generative programming, analysis and design, fra

  13. Ability, academic climate, and going abroad for work or pursuing a PhD

    NARCIS (Netherlands)

    Bertrand-Cloodt, D.A.M.; Cörvers, F.; Heijke, J.A.M.

    2014-01-01

    We investigate whether a creaming off of highly able students from Dutch universities is taking place. Therefore, we examine the relation between ability and the destination of recent graduates of Dutch universities. Students can choose to continue their academic career by investing in a PhD degree

  14. Training of young researchers and PhD supervisors for the future

    DEFF Research Database (Denmark)

    Kolmos, Anette

    2004-01-01

    which contributes to break down the usual ways of thinking and to incorporate both intercultural and interdisciplinary principles, and a valued orientation towards trade and industry. The PhD supervisors should also be trained so that light is thrown on the aims, methods and contents of the supervision...

  15. Factors Influencing International PhD Students to Study Physics in Australia

    Science.gov (United States)

    Choi, Serene H.-J.; Nieminen, Timo A.; Townson, Peter

    2012-01-01

    Since physics research is an activity of an active international community, international visits are a common way for physicists to share scientific knowledge and skills. International mobility of physicists is also important for PhD physics study and research training. We investigated personal and social factors that influenced the decision for…

  16. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  17. Classification of 5-Dimensional MD-Algebras Having Non-Commutative Derived Ideals

    CERN Document Server

    Vu, Le Anh; Nghia, Tran Thi Hieu

    2011-01-01

    The paper presents a subclass of the class of MD5-algebras and MD5-groups, i.e. five dimensional solvable Lie algebras and Lie groups such that their orbits in the co-adjoint representation (K-orbits) are orbits of zero or maximal dimension. The main result of the paper is the classification up to an isomorphism of all MD5-algebras with the non-commutative derived ideal. With this result, we have the complete classification of 5-dimensional solvable Lie algebras.

  18. MD5算法应用失败的思考

    Institute of Scientific and Technical Information of China (English)

    TC-XB

    2007-01-01

    MD5算法作为一种高强度的加密算法,被广泛的应用于软件的注册算法中。但是需要指明的是.尽管MD5本身非常强大.但是如果应用不当,那么对软件的保护效果是很难令人满意的。下面我就先说一种最常见的MD5应用失败的形式。

  19. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  20. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  1. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  2. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  3. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  4. 一种基于MD5算法的B/S通信加密系统%A MD5-based B/S communication encryption system

    Institute of Scientific and Technical Information of China (English)

    申甲

    2010-01-01

    随着网络的全面应用,以Web方式对数据进行操作的安全问题日益突出.本文针对目前广泛应用的MD5(Message Digest 5)加密算法,深入分析了MD5算法加密原理及实现过程,并利用该算法设计实现一种基于B/S(Browser/Server)方式的通信加密系统,达到了信息保密的要求.

  5. Exploring challenges of the reproductive health PhD curriculum: A qualitative research

    Directory of Open Access Journals (Sweden)

    Sh Kohan

    2016-07-01

    Full Text Available Introduction: Enhancing the quality and dynamicity of higher education programs requires continuous evaluation of curriculums. Reproductive health PhD program was established in 2006 in Iran while recommending that its curriculum be evaluated by assessing graduates’ performance in workplace and surveying students, faculty members and managers. This study aimed to explore challenges of the curriculum of reproductive health PhD program. Methods: Employing a qualitative content analysis approach and using purposive and sometimes opportunistic sampling, experiences and viewpoints of 33 graduates and students of reproductive health PhD program, educational managers and reproductive health board members about the curriculum of reproductive health PhD program were collected through individual interviews and notes in 2014-15. Data were transcribed and important expressions were coded. Classification of similar codes led to preliminary categories. Five main categories were extracted by further classifications. Results: The five main categories included inadequacy of course topics and contents, challenges of student education, failure in realizing curriculum goals, long research period, and ambiguity in graduates’ professional status were appeared; each of these included various subcategories. Conclusion: Results showed that the curriculum of reproductive health PhD program required revisions to meet the program’s mission and designing courses such as sexual health and reinforcing the clinical nature of the program were necessary. Moreover, the results emphasized that the establishment of an independent educational department of reproductive health for managing higher education affairs and greater supervision of the reproductive health board on educational affairs was necessary. Furthermore, reproductive health specialists should be employed in different positions to meet society’s reproductive health needs.

  6. A National Content Analysis of PhD Program Objectives, Structures, and Curricula: Do Programs Address the Full Range of Social Work's Needs?

    Science.gov (United States)

    Drisko, James; Hunnicutt, Christie; Berenson, Laura

    2015-01-01

    The Group for the Advancement of Doctoral Education (GADE) promotes excellence in PhD education in Social Work. GADE's 2013 Quality Guidelines for PhD Programs heavily emphasize preparation for research. Little is known, however, about the details of the contemporary social work PhD program structure and curriculum. Several prior surveys have…

  7. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  8. Collision Attack on the Full Extended MD4 and Pseudo-Preimage Attack on RIPEMD

    Institute of Scientific and Technical Information of China (English)

    Gao-Li Wang

    2013-01-01

    The cryptographic hash functions Extended MD4 and RIPEMD are double-branch hash functions,which consist of two parallel branches.Extended MD4 was proposed by Rivest in 1990,and RIPEMD was devised in the framework of the RIPE project (RACE Integrity Primitives Evaluation,1988~1992).On the basis of differential analysis and meet-in-the-middle attack principle,this paper proposes a collision attack on the full Extended MD4 and a pseudo-preimage attack on the full RIPEMD respectively.The collision attack on Extended MD4 holds with a complexity of 237,and a collision instance is presented.The pseudo-preimage attack on RIPEMD holds with a complexity of 2125,4,which optimizes the complexity order for brute-force attack.The results in this study will also be beneficial to the analysis of other double-branch hash functions such as RIPEMD-160.

  9. 好压的MD5校验功能

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    为了防止人为篡改文件.一般网上供网民下载的文件都公布了其MD5校验值,下载到本机后通过比较MD5校验值是否发生变化来判断文件是否被篡改。先选中文件,再点击好压软件“工具”菜单里的“MD5校验工具”就可查看到该文件的相关校验,可以对任意文件进行版本、文件时间、MD5值、SHAl值和CRC32值进行校验。

  10. MD5加密验证拿下

    Institute of Scientific and Technical Information of China (English)

    Crack

    2005-01-01

    在软件的加密保护中,MD5是一个经常会被用到的加密算法,但是由于MD5算法为不可逆算法所以所有的软件都只能使用MD5算法作为一个加密的中间步骤,比如对用户名做一个MD5变换,结果再进行一个可逆的加密变换,变换结果为注册码;

  11. 感受MD5暴力破解的魅力

    Institute of Scientific and Technical Information of China (English)

    冰河洗剑

    2005-01-01

    MD5密码一直是最头疼的,许多论坛和网站的密码都是MD5加密过的。当然得到了MD5加密过的密码后.有的高手可以通过Cookie欺骗或Session欺骗等方式.进入后台管理页面,但是对许多朋友来说,暴力破解MD5密码.将其还原为明文密码.再登录后台虽然有些笨.但却是比较简单有效的一种方法。

  12. 简单编写MD5破解器

    Institute of Scientific and Technical Information of China (English)

    人鱼姬

    2007-01-01

    目前国内的网络安全现状不容乐观.脚本注入还大有市场。许多脚本小子喜欢用注入工具到处乱注.拿到了管理员密码的MD5密文就开始破解,但并不是所有人都知道MD5破解是如何实现的。下面我们就用Delphi来编写一款简单的MD5破解器.同时让大家更清晰地了解MD5破解是基于什么原理实现的。

  13. 在线破解MD5网站一览

    Institute of Scientific and Technical Information of China (English)

    Tashanenjoy

    2006-01-01

    MD5加密因其不可逆性而导致了一些爆破猜测MD5工具的出现.如著名的MD5Crack.其原理是先进行MD5加密再对比提供的字符串。虽然速度也较快.但毕竟还是要“跑”一下具。有时一个密码跑30分钟也不一定能跑出来.很不划算。有没有其他的办法呢?

  14. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Science.gov (United States)

    2010-03-16

    ... Scarlet Tanager Loop, Laurel, MD 20708. FOR FURTHER INFORMATION CONTACT: Brad Knudsen, Refuge Manager... team leader or project leader (see ADDRESSES). You may also send comments anytime during the...

  15. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  16. 下载软件的MD5你检验了吗?

    Institute of Scientific and Technical Information of China (English)

    胥忠亮

    2009-01-01

    大家经常在网上下东西.可是下载下来的软件很有可能带有木马。通常软件发布者在发布软件的时候会附上软件的MD5.来防止软件被他人篡改。那程序的MD5值是什么呢?

  17. 软件保护中MD5算法的另类应用

    Institute of Scientific and Technical Information of China (English)

    TC—XB

    2006-01-01

    作为一种主流的加密算法,MD5算法广泛的应用于软件保护领域。在软件的注册保护中,MD5经常被用来对输入的注册信息进行加密。一般来说较为简单常见的用法是“MD5(注册名)=注册码”或是“MD5(注册名:机器码)=注册码”。这样的加密方法有一定的保护效果,但是随着破解技术的进步,对于这种保护方式,破解者只要能判断出使用了MD5算法,就可以很方便的做出注册机。不过不能因此否认MD5算法的优越性,所以对于MD5在软件的保护中应用,就要另辟蹊径了。下文中我们以一个Crackme为例,来看看如何更有效的使用MD5算法,并产生更好的保护效果。

  18. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  19. Parallel Cascade Selection Molecular Dynamics (PaCS-MD) to generate conformational transition pathway.

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-21

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  20. 不要宰牛刀,MD5值校对更方便

    Institute of Scientific and Technical Information of China (English)

    新玲的窗户

    2009-01-01

    在一些比较正规的网站或论坛下载软件时,在软件下载链接旁边一般都会提供该软件原始的MD5值。用MD5值工具计算出下载软件的MD5值,和原始MD5值进行校对,就可判断出下载的软件是否被修改过。但是,使用专门的工具对下载的软件进行MD5值校对比较麻烦,二来也有“杀鸡用牛刀”之嫌。其实,仅仅利用一个动态链接库文件,就可以完成MD5值的校对工作。

  1. 防止密码MD5值被破解妙招

    Institute of Scientific and Technical Information of China (English)

    晏伟

    2006-01-01

    现在的站点当中有很多密码都是经过MD5加密的,有很多人认为经过MD5加密后的密码就是安全的,即使密码MD5值被暴露也无所谓,殊不知有很多站点都能够对MD5值进行穷举解密,这些站点能够在瞬间还原1O位以下字母+数字+字符组合的密码。有些站点甚至声称数据库中有235亿条记录,这是件很可怕的事情,如果你的密码不够强大,只是由简单数字或几个字母组成,MD5值也相当于是明文!下面我就教大家一招防止MD5值被破解的妙招。

  2. The training, careers, and work of Ph.D. physical scientists: Not simply academic

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-11-01

    We present an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Use of specialized training varies widely, with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other important measures, there are relatively few differences between "academics" and "nonacademics." Important job skills for all employment sectors include writing, oral presentation, management, data analysis, designing projects, critical thinking, and working in an interdisciplinary context. Rankings given by respondents of graduate training in some of these skill areas were significantly lower than the importance of these skills in the workplace. We also found that the rated quality of graduate training varies relatively little by department or advisor. Finally, although nonacademic aspirations among graduate students are fairly common, these do not appear to be well supported while in graduate school.

  3. The use of a Virtual Community to Complement the MS PHD'S Professional Development Program

    Science.gov (United States)

    Nieves, I. U.; Brown, D. C.; Bailey, K.; Easley, R.; Johnson, A.; Ithier, W.; Powell, J. M.; Whitney, V. W.; Pyrtle, A. J.

    2005-12-01

    The aim of the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Sciencer Professional Development Program (MS PHD'S PDP) is to provide professional and mentoring experiences that facilitate the advancement of minorities committed to achieving outstanding Earth system science and engineering careers. The MS PHD'S PDP is structured in three phases that are connected by engagement in virtual community building activities, allowing for continuous peer to peer and mentor to mentee interactions. These activities occur through the use of the MSPHD'S website forum and web cam dialogues. In addition, the virtual community provides the personal and professional support necessary to ensure the success of the students. Examples of interactions within the MSPHD'S PDP virtual community will be presented.

  4. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    Directory of Open Access Journals (Sweden)

    Xiaoli Wang

    2016-07-01

    Full Text Available Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZeneca for four years before joining Agilent Technologies in 2010. Recently, he won the prestigious 2016 Young Investigator Award from Chinese American Chromatography Association (CACA. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  5. SMC-PHD based multi-target track-before-detect with nonstandard point observations model

    Institute of Scientific and Technical Information of China (English)

    占荣辉; 高彦钊; 胡杰民; 张军

    2015-01-01

    Detection and tracking of multi-target with unknown and varying number is a challenging issue, especially under the condition of low signal-to-noise ratio (SNR). A modified multi-target track-before-detect (TBD) method was proposed to tackle this issue using a nonstandard point observation model. The method was developed from sequential Monte Carlo (SMC)-based probability hypothesis density (PHD) filter, and it was implemented by modifying the original calculation in update weights of the particles and by adopting an adaptive particle sampling strategy. To efficiently execute the SMC-PHD based TBD method, a fast implementation approach was also presented by partitioning the particles into multiple subsets according to their position coordinates in 2D resolution cells of the sensor. Simulation results show the effectiveness of the proposed method for time-varying multi-target tracking using raw observation data.

  6. Strategies for a successful PhD program: words of wisdom from the WJNR Editorial Board.

    Science.gov (United States)

    Conn, Vicki S; Zerwic, Julie; Rawl, Susan; Wyman, Jean F; Larson, Janet L; Anderson, Cindy M; Fahrenwald, Nancy L; Benefield, Lazelle E; Cohen, Marlene Z; Smith, Carol E; Topp, Robert; Markis, Natalie E

    2014-01-01

    Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership. PMID:23797100

  7. Phd study of reliability and validity: One step closer to a standardized music therapy assessment model

    DEFF Research Database (Denmark)

    Jacobsen, Stine Lindahl

    The paper will present a phd study concerning reliability and validity of music therapy assessment model “Assessment of Parenting Competences” (APC) in the area of families with emotionally neglected children. This study had a multiple strategy design with a philosophical base of critical realism...... and pragmatism. The fixed design for this study was a between and within groups design in testing the APCs reliability and validity. The two different groups were parents with neglected children and parents with non-neglected children. The flexible design had a multiple case study strategy specifically...... of the theoretical understanding of the clientgroup. Furthermore, a short describtion of the specific assessment protocol and analysis procedures of APC will be a part of the presentation. The phd study sought to explore how to develop measures of parenting competences in looking at autonomy relationship...

  8. Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells.

    Science.gov (United States)

    Feng, Yi; Ying, Hai-Yan; Qu, Ying; Cai, Xiao-Bo; Xu, Ming-Yi; Lu, Lun-Gen

    2016-09-01

    Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities. However, the pharmacological effects of MT still need to be strengthened due to its relatively low efficacy and short half-life. In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell culture and animal models. Cytological experiments showed that MD-1 can inhibit the proliferation of HSC-T6 cells with a half-maximal inhibitory concentration (IC50) of 62 μmol/L. In addition, MD-1 more strongly inhibits the migration of HSC-T6 cells compared to MT and can more effectively induce G0/G1 arrest and apoptosis. Investigating the biological mechanisms underlying anti-hepatic fibrosis in the presence of MD-1, we found that MD-1 can bind the epidermal growth factor receptor (EGFR) on the surface of HSC-T6 cells, which can further inhibit the phosphorylation of EGFR and its downstream protein kinase B (Akt), resulting in decreased expression of cyclin D1 and eventual inhibition of the activation of HSC-T6 cells. Furthermore, in rats with dimethylnitrosamine (DMN)-induced hepatic fibrosis, MD-1 slowed the development and progression of hepatic fibrosis, protecting hepatic parenchymal cells and improving hepatic functions. Therefore, MD-1 is a potential drug for anti-hepatic fibrosis.

  9. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  10. Analysis of information use in agricultural science PhD theses at Central University of Venezuela

    OpenAIRE

    Haparro-Martinez, Exio Isaac; Marzal, Miguel Ángel

    2008-01-01

    Purpose – To analyze information use in agricultural science PhD theses submitted between 1986 and 2002 in the Faculty of Agronomy, Central University of Venezuela (UCV). Design/methodology/approach – The source of information was the UCV Faculty of Agronomy, Library's database, “Tesis”. The unidimensional production and use indicators analyzed included: scientific production, reference density, self-citations, document contemporaneousness and type of documents cited, reference scatterin...

  11. "Essays on International Business Cycles", PhD thesis, Economics Department, University of Chicago, 1991.

    OpenAIRE

    Kollmann, Robert

    1991-01-01

    PhD dissertation, 1991, Economics Department, University of Chicago. (Thesis committee: Michael Woodford, advisor; José Scheinkman; John Huizinga.) Models of the international economy which assume complete asset markets predict that consumption co-moves closely in different countries as this structure of asset markets allows agents in different countries to 'pool' the country-specific risks which they face (see Scheinkman (1984), Leme (1984)). Examples in this class of models include the...

  12. A call for performance-based data in the study of STEM Ph.D. education

    OpenAIRE

    David F. Feldon; Maher, Michelle A.; Timmerman, Briana E.

    2010-01-01

    Understanding the scholarly development of Ph.D. students in science, technology, engineering, and mathematics (STEM) is vital to the preparation of the scientific workforce. During doctoral study, students learn to be professional scientists and acquire the competencies to succeed in those roles. However, this complex process is not well studied. Research to date suffers from overreliance on a narrow range of methods that cannot provide data appropriate for addressing questions of causality ...

  13. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  14. Pathways to the PhD in Nursing: An Analysis of Similarities and Differences.

    Science.gov (United States)

    Nehls, Nadine; Barber, Gale; Rice, Elizabeth

    2016-01-01

    New educational pathways are needed to increase the number of doctor of philosophy (PhD)-prepared nurses. To address this need, an early-entry PhD option designed to engage students in PhD coursework and research during the undergraduate nursing major was developed at the University of Wisconsin-Madison. An evaluation comparing the early-entry option with two more conventional entry points was conducted. Three groups (N = 84) comprised the sample: (a) early-entry students admitted as undergraduates or immediately upon graduation (N = 29), (b) mid-entry students with baccalaureate degrees and at least 1 year of work experience (N = 27), and (c) delayed-entry students with master's degrees and 1 or more years of work experience (N = 28). Qualitative and quantitative data were collected from the 3 groups of students who were admitted from 2002 to 2011. The sources of data were transcriptions of individual interviews and reviews of existing data. Seventy-seven percent of the sample participated in the individual interviews. The database review included all students who matriculated into the PhD program. Common themes among the 3 groups included a need for educational funding, the importance of a faculty mentor, and concern about preparation for the teaching role and the academic work environment. The groups were also comparable in terms of research productivity during doctoral study and postgraduation employment. Differences were found on measures of diversity, program progression, and perceptions of clinical competence. The findings provide needed data for the development and expansion of educational pathways to the PhD in nursing. PMID:27216124

  15. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    3rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  16. ChemSession'11 - 8. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Book of Abstracts contains short descriptions of presentations: 4 lectures, 1 communication and 149 posters presented during ChemSession'11 - 8th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 13.05.2011). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  17. Education Blues : A Study of the Emotional Roller Coaster Rideof Ph.D. Education

    OpenAIRE

    Berggren, Uffe

    2012-01-01

    The study makes use of theories of emotions to describe and analyze interviewsconducted with eight students who had recently taken part in, or were at the moment,taking part in a doctoral education at the Faculties of Humanities or Social Science atStockholm University. This study is thus a qualitative study focusing on the followingresearch questions: Firstly, how does the Ph.D education influence the studentemotionally. Secondly: do the participants in the doctoral education experienceemoti...

  18. Governance configurations and academic outcomes: The example of Ph.D. education

    OpenAIRE

    Schneider, Peter; Sadowski, Dieter

    2010-01-01

    In many European countries efforts are undertaken to improve doctoral education. In the context of new public governance in the Higher Education sector, less state, more competition, less academic self-governance, more internal hierarchy and more influence by external stakeholders under the common roof of New Public Management (NPM) are considered most promising for successful PhD education. Therefore according to a steering model of American research universities many initiatives are underta...

  19. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    OpenAIRE

    Camelia Popa

    2013-01-01

    As a whole, this PhD thesis follows three research lines, namely: (1) the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2) the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3) the line of an awareness of the need to prevent and fight against the effects...

  20. ChemSession'07 - 4th Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    4th Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  1. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  2. 9th Workshop for PhD Students in Object Oriented Systems

    OpenAIRE

    Rashid, Awais; Parsons, David; Telea, Alexandru

    1999-01-01

    The PhDOOS workshop covered a wide scope, as its over 20 participants were PhD students in all areas of object orientation. The presentations covered topics such as databases, languages, software engineering and artificial intelligence, components and generative programming, analysis and design, frameworks and patterns, aspected oriented programming, distribution and middleware. Several topics of shared interest were identified and targeted in separate discussion groups on meta-information, t...

  3. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

    Science.gov (United States)

    German, Natalie J; Yoon, Haejin; Yusuf, Rushdia Z; Murphy, J Patrick; Finley, Lydia W S; Laurent, Gaëlle; Haas, Wilhelm; Satterstrom, F Kyle; Guarnerio, Jlenia; Zaganjor, Elma; Santos, Daniel; Pandolfi, Pier Paolo; Beck, Andrew H; Gygi, Steven P; Scadden, David T; Kaelin, William G; Haigis, Marcia C

    2016-09-15

    While much research has examined the use of glucose and glutamine by tumor cells, many cancers instead prefer to metabolize fats. Despite the pervasiveness of this phenotype, knowledge of pathways that drive fatty acid oxidation (FAO) in cancer is limited. Prolyl hydroxylase domain proteins hydroxylate substrate proline residues and have been linked to fuel switching. Here, we reveal that PHD3 rapidly triggers repression of FAO in response to nutrient abundance via hydroxylation of acetyl-coA carboxylase 2 (ACC2). We find that PHD3 expression is strongly decreased in subsets of cancer including acute myeloid leukemia (AML) and is linked to a reliance on fat catabolism regardless of external nutrient cues. Overexpressing PHD3 limits FAO via regulation of ACC2 and consequently impedes leukemia cell proliferation. Thus, loss of PHD3 enables greater utilization of fatty acids but may also serve as a metabolic and therapeutic liability by indicating cancer cell susceptibility to FAO inhibition. PMID:27635760

  4. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  5. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study.

  6. ISO/IEEE 11073 PHD message generation toolkit to standardize healthcare device.

    Science.gov (United States)

    Lim, Joon-Ho; Park, Chanyong; Park, Soo-Jun; Lee, Kyu-Chul

    2011-01-01

    As senior population increases, various healthcare devices and services are developed such as fall detection device, home hypertension management service, and etc. However, to vitalize healthcare devices and services market, standardization for interoperability between device and service must precede. To achieve the standardization goal, the IEEE 11073 Personal Health Device (PHD) group has been standardized many healthcare devices, but until now there are few devices compatible with the PHD standard. One of main reasons is that it isn't easy for device manufactures to implement standard communication module by analyzing standard documents of over 600 pages. In this paper, we propose a standard message generation toolkit to easily standardize existing non-standard healthcare devices. The proposed toolkit generates standard PHD messages using inputted device information, and the generated messages are adapted to the device with the standard state machine file. For the experiments, we develop a reference H/W, and test the proposed toolkit with three healthcare devices: blood pressure, weighting scale, and glucose meter. The proposed toolkit has an advantage that even if the user doesn't know the standard in detail, the user can easily standardize the non-standard healthcare devices.

  7. Educating future nursing scientists: Recommendations for integrating omics content in PhD programs.

    Science.gov (United States)

    Conley, Yvette P; Heitkemper, Margaret; McCarthy, Donna; Anderson, Cindy M; Corwin, Elizabeth J; Daack-Hirsch, Sandra; Dorsey, Susan G; Gregory, Katherine E; Groer, Maureen W; Henly, Susan J; Landers, Timothy; Lyon, Debra E; Taylor, Jacquelyn Y; Voss, Joachim

    2015-01-01

    Preparing the next generation of nursing scientists to conduct high-impact, competitive, sustainable, innovative, and interdisciplinary programs of research requires that the curricula for PhD programs keep pace with emerging areas of knowledge and health care/biomedical science. A field of inquiry that holds great potential to influence our understanding of the underlying biology and mechanisms of health and disease is omics. For the purpose of this article, omics refers to genomics, transcriptomics, proteomics, epigenomics, exposomics, microbiomics, and metabolomics. Traditionally, most PhD programs in schools of nursing do not incorporate this content into their core curricula. As part of the Council for the Advancement of Nursing Science's Idea Festival for Nursing Science Education, a work group charged with addressing omics preparation for the next generation of nursing scientists was convened. The purpose of this article is to describe key findings and recommendations from the work group that unanimously and enthusiastically support the incorporation of omics content into the curricula of PhD programs in nursing. The work group also calls to action faculty in schools of nursing to develop strategies to enable students needing immersion in omics science and methods to execute their research goals. PMID:26123776

  8. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  9. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study. PMID:27455365

  10. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  11. MS PHD'S: A successful model for reaching underrepresented minorities (URM) students through virtual platforms

    Science.gov (United States)

    Scott, O.; Johnson, A.; Williamson, V.; Ricciardi, L.; Jearld, A., Jr.; Guzman, W. I.

    2014-12-01

    To successfully recruit and retain underrepresented minority (URM) students and early career scientists, many programs supplement traditional curricular activities with multiple online platforms, establishing "virtual communities" that are free and easily accessible. These virtual communities offer readily sustainable opportunities to facilitate communication across a wide range of cultural lines and socioeconomic levels thereby broadening participation and inclusivity in STEM. Established in 2003, the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Earth System Science Professional Development Program has successfully used virtual community tools such as a listserv, community forum, social media, and VoIP technologies, to extend the face-to-face activities of the program and support the advancement of URM students and early career scientists in STEM. The use of multiple facets of virtual community by MS PHD'S participants supports and encourages "real life" interactions and mentorship, facilitates networking and professional development, and maintains continuity of shared networks. The program is now in its ninth cohort and supports 213 participants. To date, 54 participants have completed their PhD and another 61 are currently enrolled in doctoral programs.

  12. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  13. A Study of the Adsorption of Molecular Deposition Filming Flooding Agent MD-1 on Quartz Sand

    Institute of Scientific and Technical Information of China (English)

    GaoManglai; LiuYong; MengXiuxia; WangJianshe

    2004-01-01

    Molecular deposition filming flooding (MDFF) is a novel oil recovery technique based on the thermopositive monolayer electrostatic adsorption of the MDFF agent on different interfaces within reservoir systems. In this paper, the adsorption property of the MDFF agent, MD-I, on quartz sand has been studied through adsorption experiments at different pH and temperatures. Experimental data are also analyzed kinetically and thermodynamically. The results show that the adsorption of MD-I on quartz sand takes place mainly because of electrostatic interactions, which corresponds to adsorption that increases with pH. Kinetic analyses show that at a higher pH the activation energy for adsorption gets lower and, therefore, the adsorption becomes quicker for MD-1 on quartz sand. Thermodynamic analyses show that pH plays an important role in the adsorption of MD-1 on quartz sand. At a higher pH, more negative surface charges result in the increase of electrostatic interactions between MD-1 and quartz sand. Therefore, the saturated adsorption amount increases and more adsorption heat will be released.

  14. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  15. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  16. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  17. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  18. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  19. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  20. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  1. 改造MD5让破解程序见鬼去

    Institute of Scientific and Technical Information of China (English)

    安美洪

    2005-01-01

    也许提到MD5时大家都很熟,但你真的了解它吗?虽然一般人是不用这样去寻根问底的,要用的时候直接去下载别人已编好的程序用就得了,但象我这样的好事者总想抓住点什么另类的东西——你有没有想过自己修改MD5,让网上漫天飞的MD5破解工具变得一无是处?要是有兴趣就往下看吧!

  2. 在飞速网用MD5值搜索PE系统

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    如果你要测试某PE系统.可是很多专门下载网站的资源链接都已经失效,幸好对于操作系统这类资源.很多网站都提供下载资源的MD5值。现在只要记下失效链接网站提供的资源MD5值,然后在地址栏输入http://www.raylile.com/zh—cn/files/6FA887054AB3EE91A5F542227FDC7493(“files/”后面的内容即为要搜索文件的MD5值).回车后即可跳转到该资源的下载链接中。

  3. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  4. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU; Le; Anh; HOA; Duong; Quang

    2009-01-01

    The paper is a continuation of the authors’ works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes’ C*-algebras of the foliations which come from fibrations are also given.

  5. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  6. Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

    Science.gov (United States)

    Howell Smith, Michelle C.

    Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the

  7. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  8. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  9. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  10. MD5解密器速度加强版V2.2

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    MD5密码的破解软件很多.今天介绍的这款MD5解密器速度加强版是原作者在此软件V2.0的基础上去除了影响速度的功能.并对加密算法进行了修改的结果.速度比同类解密器快了非常多。

  11. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  12. MD5算法及在用户口令加密应用中的改进

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用。但随着科学技术的发展,MD5牢不可破的神话逐渐破灭。基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法。

  13. Building Better Bridges: An Evaluation of The Bridge to the Ph.D. Program

    Science.gov (United States)

    Ellyn Sanderson, Robyn; Lobel, Caroline; Agueros, Marcel A.; Anderson, Vanessa; Ash, Summer; Purdie-Vaughns, Valerie; Romero-Canyas, Rainer; Walker, Erica

    2016-01-01

    Columbia University's Bridge to the Ph.D. in the Natural Sciences Program is increasing the number of underrepresented scholars entering graduate programs and equipping them to succeed in these programs. In a given year, three to five Bridge participants are hired as full-time Columbia University research assistants for up to two years. Now in its seventh year, the Program supports seven participants, and its alumni (including five astronomers) have gone on to Ph.D. programs across the country. Although to date fewer than 40 people have participated in the Program, a number too small for an exclusively statistical evaluation of its effectiveness, we are collecting invaluable longitudinal data on the career progressions of underrepresented aspiring scientists across the natural sciences. At least a dozen Bridge alumni will earn their Ph.D. in the next two-three years, and we will then learn much more about the impact that the Bridge Program has had on our participants' trajectories. Among other things, we hope to use these data to determine the Program's effectiveness in developing feelings of self-efficacy and participants' confidence in their ability to succeed in doctoral programs, to measure the rate at which Bridge alumni successfully complete doctoral programs relative to their peers, and to identify the aspects of the Program that participants find most helpful to their progress at different stages of their paths to and through doctoral programs. Here we describe the data we have already obtained as part of our on-going study, and preliminary results from our analysis.

  14. Sample Size and Saturation in PhD Studies Using Qualitative Interviews

    OpenAIRE

    Mason, Mark

    2010-01-01

    A number of issues can affect sample size in qualitative research; however, the guiding principle should be the concept of saturation. This has been explored in detail by a number of authors but is still hotly debated, and some say little understood. A sample of PhD studies using qualitative approaches, and qualitative interviews as the method of data collection was taken from theses.com and contents analysed for their sample sizes. Five hundred and sixty studies were identified that fitted t...

  15. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    OpenAIRE

    Xiaoli Wang

    2016-01-01

    Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZen...

  16. The first Italian doctorate (PhD Course) in Physics Education Research

    Science.gov (United States)

    Michelini, Marisa; Santi, Lorenzo

    2008-05-01

    The first PhD Italian course in Physics Education Research in Udine aims to qualify young researchers and teachers coming from all the Italian groups of research in the field. It becomes a context for developing research projects carried out following parallel research lines on: Teaching/Learning paths for didactic innovation, cognitive research, ICT for strategies to overcome conceptual knots in physics; E-learning for personalization; d) Computer on-line experiments and modelling; e) Teacher formation and training; f) Informal learning in science.

  17. Researcher Profile: An Interview with Sonya Britt, Ph.D., CFP, AFC

    OpenAIRE

    Sonya Britt

    2013-01-01

    Sonya Britt, Ph.D., CFP, AFC graduated from Texas Tech University in 2010 with a doctorate in Personal Financial Planning. Her first two degrees are from Kansas State University in Personal Financial Planning (B.S.) and Marriage and Family Therapy (M.S.). and she was the founding president of the Financial Therapy Association and recently retired from the board as past-president. She currently serves on the board of the American Council on Consumer Interests association. Sonya is an associate...

  18. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R)

    OpenAIRE

    John Grable

    2014-01-01

    John E. Grable, Ph.D., CFP(R) teaches and conducts research in the Certified Financial Planner(TM) Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research i...

  19. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    Directory of Open Access Journals (Sweden)

    Camelia Popa

    2013-03-01

    Full Text Available As a whole, this PhD thesis follows three research lines, namely: (1 the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2 the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3 the line of an awareness of the need to prevent and fight against the effects arising from money laundering processes, the national and international efforts taken until present nation- and worldwide and the future measures required to diminish the consequences of this scourge.

  20. Twenty of China's best physics PhD students visited CERN

    CERN Document Server

    2006-01-01

    Twenty of the top physics PhD students in China were honoured with the 'E=mc2 to modern science' Einstein Award and received a three week tour of major laboratories in Germany and Switzerland, including CERN, DESY and the Max Planck Institute. The Einstein Award is co-sponsored by the German and Swiss Embassies in celebration of the 'Year of Physics' in 2005. For many years, Germany, Switzerland and China have been involved in numerous areas of scientific research and cooperation.

  1. 76 FR 60889 - Stephen L. Reitman, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... Friedel 57. Dr. William Friedel is a graduate of Brown University. He attended Albert Einstein College of Medicine, interned at Downstate in Brooklyn, New York, and returned to Albert Einstein for his residency in... substances properly if entrusted with a DEA registration.''' Id. (quoting Leonardo v. Lopez, M.D., 54...

  2. 76 FR 80230 - Amendment of Class D and E Airspace; Baltimore, MD

    Science.gov (United States)

    2011-12-23

    ... FR 72837). This action further corrects the geographic coordinates to be in concert with the FAAs..., 2011, 76 FR 72837, FR Doc. 2011-30489, are corrected as follows: AEA MD D Baltimore, Martin State... the geographic coordinates in the airspace description of a final rule published in the...

  3. An endophytic taxol-producing fungus from Taxus media, Cladosporium cladosporioides MD2.

    Science.gov (United States)

    Zhang, Peng; Zhou, Peng-Peng; Yu, Long-Jiang

    2009-09-01

    Fermentation processes using taxol-producing fungi other than Taxus spp. may be an alternative way to produce taxol, which is an important antitumor agent used widely in the clinic setting. In this study, a taxol-producing endophytic fungus strain MD2 was isolated from the inner bark of Taxus media. Strain MD2 produced taxol when grown in potato dextrose liquid medium. The fungal taxol-which was analyzed by ultraviolet, high-performance liquid chromatography and mass spectrometry-was shown to be identical to authentic taxol and 10-deacetylbaccatin III. Further analysis with nuclear magnetic resonance (NMR) spectroscopy to show the chemical structure of the fungal taxol indicated that the fungal taxol produced an NMR spectrum identical to that of authentic taxol. Strain MD2 was identified as Cladosporium cladosporioides according to morphology of the fungal culture, characteristics of the spores, and analysis of 18S rDNA sequence. In addition, 10-deacetylbaccatin III-10-O-acetyl transferase gene of C. cladosporioides MD2 was cloned for the first time and was shown to share 99% identity with that of T. x media and 97% identity with that of T. wallichiana var. mairei.

  4. 77 FR 57126 - Henri Wetselaar, M.D.; Decision and Order

    Science.gov (United States)

    2012-09-17

    ... Enforcement Administration Henri Wetselaar, M.D.; Decision and Order On September 27, 2011, I, the... * * * so you're making some pretty big steps already.'' Id. The TFO expressed his appreciation, and... he took a whole one at night to help him sleep, a whole one in the morning, and that he...

  5. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  6. Large-scale MD simulations investigating H plasma interactions with Tungsten surfaces

    Science.gov (United States)

    Cusentino, Mary Alice; Wirth, Brian

    2015-11-01

    Tungsten is a prime candidate material for the divertor in future fusion reactors such as ITER. However, the tungsten divertor will need to be able to withstand high fluxes, on the order of 1024m-2s-1, of low energy hydrogen. It is crucial to understand both the tungsten surface response as well as the hydrogen retention and recycling for the divertor region. Molecular dynamics (MD) is a useful tool to study these effects. One issue with MD is that implantation fluxes tend to be very high, on the order of 1027 m-2s-1, due to time and computational limitations. By performing large scale MD on supercomputers, it is possible to reach more realistic fluxes of 1025 m-2s-1. Results will be presented from MD simulations from a 50 nm x 50 nm x 25 nm tungsten box at 1200 K and 2000 K. Hydrogen is implanted every 10 ps based on the 60 eV depth distribution calculated by SRIM, which amounts to a flux of 4 x 1025 m-2s-1. A modified version of the Juslin bond order W-H potential is used to describe the W-H interactions. Preliminary results show an initially high retention of hydrogen that accumulates in a sub-surface region. These simulations provide insight into the early stages of surface deformation as well as hydrogen retention for the tungsten divertor.

  7. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  8. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  9. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  10. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one...). However, under Agency precedent, neither of these findings is dispositive. See Edmund Chein, 72 FR 6580, 6590 n.22 (2007); Mortimer B. Levin, 55 FR 8209, 8210 (1990). Moreover, the evidence with respect...

  11. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  12. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  13. Short Chosen-Prefix Collisions for MD5 and the Creation of a Rogue CA Certificate

    NARCIS (Netherlands)

    Stevens, M.M.J.; Sotirov, A.; Appelbaum, J.; Lenstra, A.K.; Molnar, D.; Osvik, D.A.; Weger, B. de

    2009-01-01

    We present a refined chosen-prefix collision construction for MD5 that allowed creation of a rogue Certification Authority (CA) certificate, based on a collision with a regular end-user website certificate provided by a commercial CA. Compared to the previous construction from Eurocrypt 2007, this p

  14. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  15. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  16. PHYSICAL PROPERTIES OF NEAR-EARTH ASTEROID 2011 MD

    Energy Technology Data Exchange (ETDEWEB)

    Mommert, M.; Trilling, D. E. [Department of Physics and Astronomy, Northern Arizona University, P.O. Box 6010, Flagstaff, AZ 86011 (United States); Farnocchia, D.; Chesley, S. R.; Chodas, P. W. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Hora, J. L.; Smith, H. A.; Fazio, G. G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 65, Cambridge, MA 02138-1516 (United States); Mueller, M. [SRON Netherlands Institute for Space Research, Postbus 800, 9700-AV Groningen (Netherlands); Harris, A. W. [DLR Institute of Planetary Research, Rutherfordstrasse 2, D-12489 Berlin (Germany)

    2014-07-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 hr of observing time with channel 2 (4.5 μm) of the Infrared Array Camera and detected the target within the 2σ positional uncertainty ellipse. Using an asteroid thermophysical model and a model of nongravitational forces acting upon the object, we constrain the physical properties of 2011 MD, based on the measured flux density and available astrometry data. We estimate 2011 MD to be (6{sub −2}{sup +4}) m in diameter with a geometric albedo of 0.3{sub −0.2}{sup +0.4} (uncertainties are 1σ). We find the asteroid's most probable bulk density to be (1.1{sub −0.5}{sup +0.7}) g cm{sup –3}, which implies a total mass of (50-350) t and a macroporosity of ≥65%, assuming a material bulk density typical of non-primitive meteorite materials. A high degree of macroporosity suggests that 2011 MD is a rubble-pile asteroid, the rotation of which is more likely to be retrograde than prograde.

  17. 76 FR 16823 - Robert L. Dougherty, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-25

    ... previously held a DEA Certificate of Registration as a practitioner. Robert L. Dougherty, Jr., M.D., 60 FR... prescribing of controlled substances to three patients. Id. (citing 60 FR 55047). More specifically, the Show... treatment record of Patient 1 could have ultimately jeopardized that patient's welfare.'' 60 FR at 55051....

  18. 78 FR 62666 - Kenneth Harold Bull, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... to 100 patients for opiate addiction with Suboxone and Subutex under the Drug Addiction Treatment Act... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). It... Krishna-Iyer, 74 FR 459, 462 (2009). Accordingly, as the Tenth Circuit has recognized, findings under...

  19. 78 FR 19012 - Pawan Kumar Jain, M.D.; Decision And Order

    Science.gov (United States)

    2013-03-28

    ...., 65 FR 5,661 (DEA 2000); Jesus R. Juarez, M.D., 62 FR 14,945 (DEA 1997). Accordingly, both the plain... to practice medicine or handle controlled substances in the State of New Mexico'' and Respondent's... alleged that the New Mexico State Medical Board took action against the Respondent on June 28, 2012. ....

  20. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant..., and psilocybin mushrooms (psilocybin or mushrooms). Gov't Exs. 4, 8; Tr. 99. More specifically, the...; \\26\\ and 0.8 grams of psilocybin mushrooms.\\27\\ Gov't Ex. 4. While most of the drugs that were...

  1. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  2. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  3. 33 CFR 334.140 - Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md.

    Science.gov (United States)

    2010-07-01

    ....140 Chesapeake Bay; U.S. Army Proving Ground Reservation, Aberdeen, Md. (a) Restricted area defined. The following indicates the limits of the waters of or adjacent to the Aberdeen Proving Ground, Maryland, and inside of which boundaries will lie the restricted area known as the Aberdeen Proving...

  4. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Science.gov (United States)

    2013-10-01

    ...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments......

  5. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... 3118-3121] [FR Doc No: 2012-1172] DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 165 [Docket No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD..., U.S. Coast Guard, Captain of the Port Baltimore. [FR Doc. 2012-1172 Filed 1-20-12; 8:45 am]...

  6. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  7. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  8. Characterizing a point mutation within the UL5 gene that reduces in vivo replication and MD incidence

    Science.gov (United States)

    Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus of chickens and the causative agent for Marek’s disease (MD). Vaccination is the primary method to control MD. Despite the success of vaccination, more virulent field strains are evolving, requiring the development of new vaccines. Attenua...

  9. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  10. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  11. 33 CFR 334.170 - Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range, Naval Research Laboratory.

    Science.gov (United States)

    2010-07-01

    ... of Chesapeake Beach, Md.; firing range, Naval Research Laboratory. 334.170 Section 334.170 Navigation... RESTRICTED AREA REGULATIONS § 334.170 Chesapeake Bay, in the vicinity of Chesapeake Beach, Md.; firing range... on the west by the shore of Chesapeake Bay. (2) Area B. The sector of a circle bounded by radii of...

  12. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lipopol...ysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

  13. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  14. Research of incremental extraction based on MD5 and HASH algorithm%融入MD5的HASH线性获取增量算法研究

    Institute of Scientific and Technical Information of China (English)

    郭亮; 杨金民

    2014-01-01

    To achieve rapid incremental extraction of database, an algorithm which is blended MD5 in HASH linear scan-ning to obtain increment is put forward based on analyzing the traditional incremental extraction. Each record in database can be seen as a character string and it can be generated into hash table as duplicate record, which is explored in hash table through traditional record to obtain increment and decrease frequency of comparison. Meanwhile, the fingerprint of each record can be generated with using MD5 algorithm, which reduces the length of character string in every HASH algorithm and comparison and improves efficiency. This algorithm is applicably tested in ORACLE database and the result shows that it is improved on calculative efficiency at a large extent compared with traditional algorithm.%为了实现数据库中的快速增量提取,在剖析传统的增量提取方法上,提出了一种融入MD5的HASH线性扫描来获取增量的算法。数据库中的每条记录都可视为一个字符串,利用HASH算法生成备份记录的散列表,通过原始记录去散列表中探测来达到线性扫描就能获取增量的目的,减少了比对次数;同时利用MD5算法生成每条记录的“指纹”,降低了每次HASH运算和比对的字符串长度,提高了效率。对所提出算法在ORACLE数据库上进行了应用测试,结果表明该算法效率较传统方法有很大提高。

  15. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  16. Home healthcare settop-box for senior chronic care using ISO/IEEE 11073 PHD standard.

    Science.gov (United States)

    Lim, Joon-Ho; Park, Chanyong; Park, Soo-Jun

    2010-01-01

    As the number of seniors with chronic disease increases, the need of home healthcare settop-box is increased to manage their chronic disease in their home environment. Using the home healthcare settop-box, the patients can regularly check their health data, and finally, it can lead the decrease of medical expenses. For the home healthcare settop-box, the most important factor is the standard compatibility, which can interoperate with standard devices of any other companies. In this paper, we propose a home healthcare settop-box using ISO/IEEE 11073 PHD standard. It collects health data according to the PHD standard, and provides a chronic-care service based on the collected data. The proposed settop-box is connected with 3 devices of weigh scale, blood pressure monitor, and glucose meter, and tested at 10 homes for a month. Lastly, the proposed settop-box can be used for various healthcare services such as Google Health and Telemedicine Services using a healthcare platform server.

  17. First ‘Gentner Doktor’ finishes PhD at CERN

    CERN Multimedia

    Jordan Juras

    2011-01-01

    In 2007, the CERN Doctoral Student Programme saw the addition of the Gentner Doctoral Student Programme, named in honour of the celebrated nuclear physicist, Wolfgang Gentner. Four years later, on 22 June 2011, Marcel Schuh finished his PhD with a thesis in the field of accelerator technology and became the very first ‘Gentner Doktor’.   Marcel Schuh, first 'Gentner Doktor', celebrates completing his PhD. (Photo by Carsten P. Welsch) Marcel Schuh became a Gentner student in April 2008, after completing a physics degree in 2007 at the University of Heidelberg. His thesis allowed him to gain exposure to CERN and the LHC, as he worked on monitoring and control systems for trigger and readout electronics on the ALICE detector at the LHC. With the support of university supervisor, Carsten P. Welsch, Schuh applied for a Gentner Doctoral Studentship on the Superconducting Proton Linac (SPL) project. “My task was to evaluate whether dedicated higher order mode (HOM) coupler...

  18. Next gen PhD a guide to career paths in science

    CERN Document Server

    Sinche, Melanie V

    2016-01-01

    For decades, top scientists in colleges and universities pursued a clear path to success: enroll in a prestigious graduate program, conduct research, publish papers, complete the PhD, pursue postdoctoral work. With perseverance and a bit of luck, a tenure-track professorship awaited at the end. In today s academic job market, this scenario represents the exception. As the number of newly conferred science PhDs keeps rising, the number of tenured professorships remains stubbornly stagnant. Only 14 percent of those with PhDs in science occupy tenure-track positions five years after completing their degree. Next Gen PhD provides a frank and up-to-date assessment of the current career landscape facing science PhDs. Nonfaculty careers once considered Plan B are now preferred by the majority of degree holders, says Melanie Sinche. An upper-level science degree is a prized asset in the eyes of many employers, and a majority of science PhDs build rewarding careers both inside and outside the university. A certified ...

  19. Destruction of medium already affected by destructive disorder: fibrillating atria conceptually need of therapeutic help rather than surgical or ablative destruction Credits: Dr. Petras Stirbys MD, PhD

    Directory of Open Access Journals (Sweden)

    Dr. Petras Stirbys MD, PhD

    2014-06-01

    Full Text Available Atrial fibrillation (AF as the most common supraventricular arrhythmia is scarcely amenable to contemporary treatment. Due to the diverse origin and variable clinical course of AF there is a broad spectrum of therapy options. However, optimal AF management has not become a gold standard yet. In general, the recurrence rate of AF is most often clinically unacceptable despite drug, surgical and/or ablation therapy. Substrate-based approach and ongoing ablation of atrial wall in its selected areas including the vicinity of pulmonary veins can be harmful. Applied physical factors do produce total disintegration of cardiomyocites – both intra- and inter-cellular damage which, in turn, leads to functional hypo-/inactivation of atria irrespective of whether the sinus rhythm is restored or not. In fact, iatrogenic phenomenon of ablation-induced atrial incompetence did emerge. Heterogeneity in clinical results reflects the uncertainty regarding the efficacy, risks and benefits of invasive AF therapy. In this regard the overall burden of AF may increase when using current therapy methods. Applicability of destructive techniques is yet to be fully elucidated and discussed. We hypothesize that currently used ablation and/or surgical techniques are potentially harmful since the success rates are likely achieved through violation of atrial myocardium. That is why a new and well-designed therapeutic strategy is needed. Invention of highly selective curative methods producing fibrillatory/electric blockage with concomitant saving of atrial transport function is to be encouraged.

  20. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    Science.gov (United States)

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC).

  1. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    Science.gov (United States)

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC). PMID:26027580

  2. Determination of Carbofuran and Pirimicarb from Panax notoginseng (Burk.)F.H.Chen and Poria cocos (Schw.) Wolf%中药三七、茯苓中克百威和抗蚜威的测定

    Institute of Scientific and Technical Information of China (English)

    张举成; 刘卫; 陈瑞; 杨金; 姚立华; 胡蓉绘

    2011-01-01

    [Aims] It was to develop the detection method of carbofuran and pirimicarb from Panax notoginseng (Burk.) F.H.Chen and Poria cocos (Schw.) Wolf. [Methods] The HPLC was employed to determine the carbofuran and pirimicarb from P. Notoginseng (Burk.) F.H.Chen and P. Cocos (Schw.) Wolf. [Results] The chromgraphy conditions was confirmed that the temperature was 30 °C, the velocity was 1 mL/min, the detection wavelength was 210 nm, and the mobile phase was water-acetonitrile (61.5 :38.5, by vol). The linear content of pirimicarb and carbofuran ranged from 1.99×10-4 to 9.95×l0-4μg (r=0.9987) and 1.97×10-4 to 9.85×10-4 μg (r=0.9947) respectively. The RSD of pirimicarb and carbofuran were 13.2 and 7.1% respectively. [Conclusions] The detection method was established and the two pesticides were undetected in the two Chinese herbs. The method had short retention time and the peak didn't overlap with the base material.%[目的]获得中药三七、茯苓中克百威和抗蚜威的检测方法.[方法]通过液相色谱法对中药三七和茯苓中的克百威和抗蚜威的检测方法进行研究.[结果]确定了较优液相色谱检测条件为柱温30℃,流速1 mL/min,检测波长210nm,流动相水-乙腈(体积比61.5:38.5).获得抗蚜威和克百威分别在1.99×10-4~9.95×10-4 μg(r=0.9987)和1.97×10-4~9.85×10-4μg(r=0.9947)范围内线性良好.克百威和抗蚜威的RSD值分别为13.2%和7.1%.[结论]获得了克百威和抗蚜威的检测方法,并且2种中药样品中不含有克百威和抗蚜威.该方法出峰快,能避开受试中药中基质的干扰.

  3. Modelling research: a collaborative approach to helping PhD students develop higher-level research skills

    Science.gov (United States)

    Garcia-Perez, Alexeis; Ayres, Robert

    2012-06-01

    A high proportion of PhD candidates in science and engineering fail to complete their degrees. This paper reports the results of a series of workshops where experienced researchers and supervisors were brought together with PhD students to discuss and develop a model of the PhD process. The objective was to help students develop a more rounded and thoughtful approach to their work. The impact of the workshops was assessed by carrying out structured interviews and coding the results to determine the impact on participant perceptions. The analysis suggests that the approach is effective in helping participants to clarify their thinking about the research process in which they are engaged. A proportion of participants appear to have moved from a tactical to a more strategic approach to their research. The study involved students in a postgraduate university but has implications for training of all research students in applied disciplines.

  4. COMPARISON OF RESEARCH ENGAGEMENT OF PHD STUDENTS AT VARIOUS STUDY PROGRAMS AT CULS PRAGUE: AN INTRODUCTORY STUDY

    Directory of Open Access Journals (Sweden)

    FLÉGL, Martin

    2014-12-01

    Full Text Available In an attempt to improve the quality of doctoral studies and the satisfaction of PhD students at the Czech University of Life Sciences Prague (CULS Prague the authors disseminated online questionnaire among all PhD students in May and June 2014. The questionnaire covered areas related to doctoral study, PhD supervisors, doctoral scholarship, research publications, and last but not least, to satisfaction with the doctoral study. In this article responses related to research, such as allocation of time to doctoral studies, allocation of time to research, involvement in research projects and satisfaction with research outputs. The authors provide comparison of all above mentioned domains according to faculties as well as form of doctoral studies at CULS Prague.

  5. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  6. The Road to Become a Legitimate Scholar: A Case Study of International PhD Students in Science and Engineering

    Directory of Open Access Journals (Sweden)

    Pia Bøgelund

    2015-11-01

    Full Text Available The purpose of the doctoral education process is to create and legitimize scholarly researchers. This transformation, from student to scholar, is widely discussed in the literature. However, recent rapid changes in university culture have resulted in less time for supervision, stricter completion deadlines, and a greater focus on efficiency and productivity. This has had an impact on this transition process, and this impact has not been widely studied. The aim of this article is to understand the consequences of the current trends for PhD students and the education of PhD students in general. The article is based on interviews with 14 international students from two different research programs at the Faculty of Engineering and Science at Aalborg University in Denmark. The case of international PhD students in a western setting is singled out as a challenging case for becoming a legitimate scholar, since they face the additional challenge of becoming socialised into their new foreign setting. Overall, the study concludes that the transition process of doctoral students is affected by the way different supervisors deal with current university trends and how PhD students fit or do not fit into their knowledge production practices. The study identifies matches or mismatches in a knowledge production perspective, quality of contact, and degree of independence of the PhD student as factors that influence whether a transition process can be marked as sound, troublesome, or lacking. Finally, the study identifies an overall risk of neglecting the more interdependent types of international PhD students. Suggestions are given as how to address this risk.

  7. Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

    Directory of Open Access Journals (Sweden)

    Kevin J Paik

    Full Text Available The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1α is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological half-life of less than five minutes. Here we investigated the therapeutic potential of inhibiting HIF-1α degradation through short hairpin RNA silencing of PHD-2 in the setting of diabetic wounds and limb ischemia. Treatment of diabetic mouse fibroblasts with shPHD-2 in vitro resulted in decreased levels of PHD-2 transcript demonstrated by qRT-PCR, higher levels of HIF-1α as measured by western blot, and higher expression of the downstream angiogenic genes SDF-1 and VEGFα, as measured by qRT-PCR. In vivo, shPHD-2 accelerated healing of full thickness excisional wounds in diabetic mice compared to shScr control, (14.33 ± 0.45 days vs. 19 ± 0.33 days and was associated with an increased vascular density. Delivery of shPHD-2 also resulted in improved perfusion of ischemic hind limbs compared to shScr, prevention of distal digit tip necrosis, and increased survival of muscle tissue. Knockdown of PHD-2 through shRNA treatment has the potential to stimulate angiogenesis through overexpression of HIF-1α and upregulation of pro-angiogenic genes downstream of HIF-1α, and may represent a viable, non-viral approach to gene therapy for ischemia related applications.

  8. The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.

    Directory of Open Access Journals (Sweden)

    Nada Lallous

    Full Text Available The human UHRF1 protein (ubiquitin-like containing PHD and RING finger domains 1 has emerged as a potential cancer target due to its implication in cell cycle regulation, maintenance of DNA methylation after replication and heterochromatin formation. UHRF1 functions as an adaptor protein that binds to histones and recruits histone modifying enzymes, like HDAC1 or G9a, which exert their action on chromatin. In this work, we show the binding specificity of the PHD finger of human UHRF1 (huUHRF1-PHD towards unmodified histone H3 N-terminal tail using native gel electrophoresis and isothermal titration calorimetry. We report the molecular basis of this interaction by determining the crystal structure of huUHRF1-PHD in complex with the histone H3 N-terminal tail. The structure reveals a new mode of histone recognition involving an extra conserved zinc finger preceding the conventional PHD finger region. This additional zinc finger forms part of a large surface cavity that accommodates the side chain of the histone H3 lysine K4 (H3K4 regardless of its methylation state. Mutation of Q330, which specifically interacts with H3K4, to alanine has no effect on the binding, suggesting a loose interaction between huUHRF1-PHD and H3K4. On the other hand, the recognition appears to rely on histone H3R2, which fits snugly into a groove on the protein and makes tight interactions with the conserved aspartates D334 and D337. Indeed, a mutation of the former aspartate disrupts the formation of the complex, while mutating the latter decreases the binding affinity nine-fold.

  9. MD5算法在档案管理系统中的应用%Application of MD5 Algorithm in File Management System

    Institute of Scientific and Technical Information of China (English)

    徐宝清; 赵乾宗

    2015-01-01

    along with the country to the information development and the culture education the increasing attention, the file man⁃agement system is becoming more and more popular. At the same time, with the increase of the amount of archives and the amount of users, the file management system is developing towards more automatic and humane direction.. In order to make the system more accord with the safety standards, the system will use MD5 encryption algorithm for user identity authentication.%随着国家对信息化发展和文化教育的日益重视,档案管理系统正变得越来越普及。与此同时,伴随着档案量和用户量的不断增加,档案管理系统也向着更加自动化和人性化的方向发展。为了使系统更加符合安全标准,系统将采用MD5加密算法对用户身份进行有效认证。

  10. Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems.

    Science.gov (United States)

    Ghanakota, Phani; Carlson, Heather A

    2016-08-25

    Mixed-solvent molecular dynamics (MixMD) is a hotspot-mapping technique that relies on molecular dynamics simulations of proteins in binary solvent mixtures. Previous work on MixMD has established the technique's effectiveness in capturing binding sites of small organic compounds. In this work, we show that MixMD can identify both competitive and allosteric sites on proteins. The MixMD approach embraces full protein flexibility and allows competition between solvent probes and water. Sites preferentially mapped by probe molecules are more likely to be binding hotspots. There are two important requirements for the identification of ligand-binding hotspots: (1) hotspots must be mapped at very high signal-to-noise ratio and (2) the hotspots must be mapped by multiple probe types. We have developed our mapping protocol around acetonitrile, isopropanol, and pyrimidine as probe solvents because they allowed us to capture hydrophilic, hydrophobic, hydrogen-bonding, and aromatic interactions. Charged probes were needed for mapping one target, and we introduce them in this work. In order to demonstrate the robust nature and wide applicability of the technique, a combined total of 5 μs of MixMD was applied across several protein targets known to exhibit allosteric modulation. Most notably, all the protein crystal structures used to initiate our simulations had no allosteric ligands bound, so there was no preorganization of the sites to predispose the simulations to find the allosteric hotspots. The protein test cases were ABL Kinase, Androgen Receptor, CHK1 Kinase, Glucokinase, PDK1 Kinase, Farnesyl Pyrophosphate Synthase, and Protein-Tyrosine Phosphatase 1B. The success of the technique is demonstrated by the fact that the top-four sites solely map the competitive and allosteric sites. Lower-ranked sites consistently map other biologically relevant sites, multimerization interfaces, or crystal-packing interfaces. Lastly, we highlight the importance of including protein

  11. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  12. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  13. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference

    OpenAIRE

    C. SEGRÉ

    2010-01-01

    The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19–21 May 2010 http://www.semm.it/events_researchPast.php The Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe. The core participanting institutes ...

  14. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A;

    2015-01-01

    Cancer-associated fibroblasts (CAFs) interact with tumour cells and promote growth and metastasis. Here, we show that CAF activation is reversible: chronic hypoxia deactivates CAFs, resulting in the loss of contractile force, reduced remodelling of the surrounding extracellular matrix and......, which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co...

  15. Java安全包的MD5防穷举变换算法的研究与实现%Research and Implementation of MD5 Anti-exhaustive Algrithm based on Java Security Package

    Institute of Scientific and Technical Information of China (English)

    傅旭光

    2009-01-01

    分析了MD5加密算法和碰撞的原理,对目前常规MD5算法加密结果容易被破解的问题,利用JDK的java.security包中的MD5算法给出了JavaBeans形式的变换算法,以期进一步减小破解时碰撞的概率,增强系统加密的安全性.

  16. Are MS in Economics Programs in Departments That Also Have a PhD Program in Economics Different from Their Counterparts?

    Science.gov (United States)

    Milkman, Martin I.; Marjadi, Riza; McCoy, James P.

    2016-01-01

    This is the first article that compares terminal master's degree programs in economics from universities that have a PhD program in economics with those that do not offer PhD programs in economics. The authors compare these differences based on surveys in 2002 and 2012. They examine differences in general program characteristics, department…

  17. Vacuum Structure of Twisted Scalar Field Theories on $M^{D-1} \\otimes S^{1}$

    CERN Document Server

    Hatanaka, H; Ohnishi, K; Sakamoto, M

    2001-01-01

    We study scalar field theories on M^{D-1} \\otimes S^1, which allow to impose twisted boundary conditions for the S^1 direction, in detail and report several interesting properties overlooked so far. One of characteristic features is the appearance of critical radii of the circle S^1. A phase transition can occur at the classical level or can be caused by quantum effects. Radiative corrections can restore broken symmetries or can break symmetries for small radius. A surprising feature is that the translational invariance for the S^1 direction can spontaneously be broken. A particular class of coordinate-dependent vacuum configurations is clarified and the O(N) \\phi^4 model on M^{D-1}\\otimes S^1 is extensively studied, as an illustrative example.

  18. Role of Calcium Ion in Apoptosis of MD Cancer Cells Induced by Arsenic Trioxide

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiuli; WANG Jintao; XU Shiwen

    2008-01-01

    In order to observe the role of calcium ion in apoptosis of MD cancer cells induced by arsenic trioxide, inhibition percentage was detected by MTT assay;morphology changes were examined by fluorescence microscope;apoptosis was examined by DNA Ladder;[Ca2+]i was investigated by spectrofluorimeter in vitro on MDCC-MSB1 cells. The results showed that As2O3 inhibited the proliferation of MDCC-MSB1 cells in concentration dependent manner (P<0.05 or P<0.01);typical apoptosis character was observed by fluorescence microscope;DNA Ladder was observed;the [Ca2+]i was elevated significantly after the treatment of As203 (P<0.05 or P<0.01) and showed a dose-dependent manner. It is concluded that the calcium may play an important role in apoptosis of MD cancer cells induced by arsenic trioxide.

  19. A Compact Starburst Core in the Dusty Lyman Break Galaxy Westphal-MD11

    CERN Document Server

    Baker, A J; Lehnert, M D; Lutz, D; Tacconi, L J; Baker, Andrew J.; Tacconi, Linda J.; Genzel, Reinhard; Lutz, Dieter

    2004-01-01

    Using the IRAM Plateau de Bure Interferometer, we have searched for CO(3-2) emission from the dusty Lyman break galaxy Westphal-MD11 at z = 2.98. Our sensitive upper limit is surprisingly low relative to the system's 850 um flux density and implies a far-IR/CO luminosity ratio as elevated as those seen in local ultraluminous mergers. We conclude that the observed dust emission must originate in a compact structure radiating near its blackbody limit and that a relatively modest molecular gas reservoir must be fuelling an intense nuclear starburst (and/or deeply buried active nucleus) that may have been triggered by a major merger. In this regard, Westphal-MD11 contrasts strikingly with the lensed Lyman break galaxy MS1512-cB58, which is being observed apparently midway through an extended episode of more quiescent disk star formation.

  20. Molecular dynamics (MD) calculation of the real zeta potential of neutral surfaces

    CERN Document Server

    Liu, Hongyi

    2013-01-01

    Molecular dynamics (MD) simulations of the zeta potential are so poor that it has become common to term their predictions "apparent". Here we demonstrate how MD methods can predict zeta potentials accurate enough they can be termed "real". The critical new aspects of our method are: (1) integrating the net average charge in surface-parallel layers from the midpoint of the fluid layer (where the electrostatic potential is zero) to and then into two solid caps, (2) determining the position of slipping plane with separate Couette flow models, and (3) calculating the charge distribution and electrostatic potential under static conditions. The solids are charge neutral surfaces composed of atoms with zero charge or charge balanced monovalent or divalent ions. The zeta potentials calculated are within a few millivolts of measured values, and the measured values fall within the simulation error bars. The zeta potentials calculated with the Helmholtz and Smoluchowski equation following current practice are 10's of mi...

  1. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB)

    CERN Document Server

    Morisset, Christophe; Flores-Fajardo, Nahiely

    2014-01-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (Planetary Nebulae, H II regions, etc). Grid of models are performed to understand what are the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort of resolving both of these issues in the form of a database of photoionization models, easily accessible throught the MySQL protocol, and containing a lot of usefull outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  2. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Agrawal

    2013-09-01

    Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

  3. Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment

    Science.gov (United States)

    Wernham, Madelaine; Jarrett, Pamela G.; Stewart, Connie; MacDonald, Elizabeth; MacNeil, Donna; Hobbs, Cynthia

    2014-01-01

    Background The assessment of fitness to drive in patients with cognitive impairment is complex. The SIMARD MD was developed to assist with assessing fitness to drive. This study compares the clinical decision made by a geriatrician regarding driving with the SIMARD MD score. Methods Patients with a diagnosis of mild dementia or mild cognitive impairment, who had a SIMARD MD test, were included in the sample. A retrospective chart review was completed to gather diagnosis, driving status, and cognitive and functional information. Results Sixty-three patients were identified and 57 met the inclusion criteria. The mean age was 77.1 years (SD 8.9). The most common diagnosis was Alzheimer’s disease in 22 (38.6%) patients. The mean MMSE score was 24.9 (SD 3.34) and the mean MoCA was 19.9 (SD 3.58). The mean SIMARD MD score was 37.2 (SD 19.54). Twenty-four patients had a SIMARD MD score ≤ 30, twenty-eight between 31–70, and five scored > 70. The SIMARD MD scores did not differ significantly compared to the clinical decision (ANOVA p value = 0.14). Conclusions There was no association between the SIMARD MD scores and the geriatricians’ clinical decision regarding fitness to drive in persons with mild dementia or mild cognitive impairment. PMID:24883164

  4. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  5. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    OpenAIRE

    Ravel, Jacques; Mazmanian, Sarkis K.

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research...

  6. The path ahead for MD/PhD programs in Canada Commentary on Jones et al.

    Science.gov (United States)

    Rosenblum, Norman D

    2016-01-01

    The paper by Jones and colleagues, published in this edition of Clinical Investigative Medicine, contributes to our understanding of Canadian MD/PhD Programs. While there has been little published on this subject by the Canadian programs, themselves, this paper is the most recent in a series by leaders of the Clinical Investigator Trainee Association of Canada (CITAC). The authors are to be commended for their efforts and productivity. PMID:27619401

  7. Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX) for Bionanosystem Simulations

    OpenAIRE

    Miao, Yinglong; Ortoleva, Peter J.

    2009-01-01

    A multiscale approach, Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX), to the all-atom simulation of large bionanosystems is presented. The approach starts with the introduction of a set of order parameters (OPs) automatically generated with orthogonal polynomials to characterize the nanoscale features of bionanosystems. The OPs are shown to evolve slowly via Newton’s equations and the all-atom multiscale analysis (AMA) developed earlier1 demonstrates the existence of their stochas...

  8. A unified architecture of MD5 and RIPEMD-160 hash algorithms

    OpenAIRE

    Ng, CW; Ng, TS; Yip, KW

    2004-01-01

    Hash algorithms are important components in many cryptographic applications and security protocol suites. In this paper, a unified architecture for MD5 and RIPEMD-160 hash algorithms is developed. These two algorithms are different in speed and security level. Therefore, a unified hardware design allows applications to switch from one algorithm to another based on different requirements. The architecture has been implemented using Altera's EPF10K50SBC356-1, providing a throughput over 200Mbit...

  9. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  10. MD/MBA Students: An Analysis of Medical Student Career Choice

    OpenAIRE

    Sherrill, Windsor Westbrook

    2009-01-01

    Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Me...

  11. ExTASY: Scalable and Flexible Coupling of MD Simulations and Advanced Sampling Techniques

    OpenAIRE

    Balasubramanian, Vivekanandan; Bethune, Iain; Shkurti, Ardita; Breitmoser, Elena; Hruska, Eugen; Clementi, Cecilia; Laughton, Charles; Jha, Shantenu

    2016-01-01

    For many macromolecular systems the accurate sampling of the relevant regions on the potential energy surface cannot be obtained by a single, long Molecular Dynamics (MD) trajectory. New approaches are required to promote more efficient sampling. We present the design and implementation of the Extensible Toolkit for Advanced Sampling and analYsis (ExTASY) for building and executing advanced sampling workflows on HPC systems. ExTASY provides Python based "templated scripts" that interface to a...

  12. Measurement of the Mass Difference m(D_s^+) - m(D^+) at CDF II

    CERN Document Server

    Acosta, D; Ahn, M H; Akimoto, T; Albrow, M G; Alcorn, B; Alexander, C; Allen, D; Allspach, D H; Amaral, P; Ambrose, D; Amendolia, S R; Amidei, D; Amundson, J F; Anastassov, A; Anderson, J; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Asakawa, T; Ashmanskas, W; Attal, A; Avanzini, C; Azfar, F; Azzi-Bacchetta, P; Babik, M; Bacchetta, N; Bachacou, H; Badgett, W F; Bailey, S; Bakken, J; Barbaro-Galtieri, A; Bardi, A; Bari, M; Barker, G; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Barsotti, E; Basti, A; Bauer, G; Beckner, D; Bedeschi, F; Behari, S; Belforte, S; Bell, W H; Bellendir, G; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Berg, B; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bogdan, M; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bowden, M; Box, D; Bromberg, C; Brown, W; Brozovic, M; Brubaker, E; Buckley-Geer, L; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byon-Wagner, A; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canal, P; Canepa, A; Carithers, W C; Carlsmith, D; Carosi, R; Carrell, K; Carter, H; Caskey, W; Castro, A; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chandler, J T; Chapman, J; Chappa, S; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Cisko, S; Clark, A G; Coca, M; Coiley, K; Colijn, A P; Colombo, R M; Connolly, A; Convery, M; Conway, J; Cooper, G; Cordelli, M; Cortiana, G; Cranshaw, J; Cudzewicz, R; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Dal Monte, L; Da Ronco, S; D'Auria, S; Davila, R; Dawson, J; Dawson, T; De Barbaro, P; De Baun, C; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; De Maat, R; Demar, P; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Derylo, G; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donno, F; D'Onofrio, M; Dorigo, T; Downing, R; Drake, G; Drennan, C; Drollinger, V; Dunietz, Isard; Dyer, A; Ebina, K; Eddy, N; Ely, R; Engels, E; Erbacher, R D; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Fischler, M; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fromm, J; Fujii, Y; Furic, I; Galeotti, S; Galet, G; Gallas, A; Gallinaro, M; Ganel, O; García, C; García-Sciveres, M; Garfinkel, A F; Garwacki, M; Garzoglio, G; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Gerstenslager, J; Giacchetti, L; Giagu, S; Giannetti, P; Gibson, A; Gillespie, G; Gingu, C; Ginsburg, C; Giolo, K; Giordani, M; Glagolev, V; Glenzinski, D A; Glossen, R; Gold, M; Goldschmidt, N; Goldstein, D B; Goldstein, J; Gómez, G; Goncharov, M; González, H; Gordon, S; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Grado, J; Gregori, M; Gresele, A; Griffin, T; Grim, G; Grimm, C; Gromoll, S; Grosso-Pilcher, C; Gu, C; Guarino, V; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, A; Hahn, K; Hahn, S R; Halkiadakis, E; Hall, C; Handler, R; Haney, M; Hao, W; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington, J; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hawke, T; Hays, C; Heider, E; Heinemann, B; Heinrich, J; Heiss, A; Hennecke, M; Herber, R; Herndon, M; Herren, M; Hicks, D; Hill, C; Hirschbuehl, D; Höcker, A; Hoff, J; Hoffman, K D; Hoftiezer, J H; Holloway, A; Holloway, L E; Holm, S; Holmgren, D; Hou, S; Houlden, M A; Howell, J; Hrycyk, M; Hubbard, P; Hughes, R E; Huffman, B T; Humbert, J; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, I; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jetton, R; Johnson, M; Jones, M; Jones, T; Jun, S Y; Junk, T R; Kallenbach, Jeff; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kasha, H; Kasten, M; Kato, Y; Kemp, Y; Kennedy, R D; Kephart, K; Kephart, R D; Khazins, D; Khotilovich, V; Kilminster, B; Kim, B J; Kim, D H; Kim, H S; Kim, J; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirk, M; Kirsch, L; Klein, R; Klimenko, S; Knapp, M; Knoblauch, D; Knuteson, B; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kononenko, W; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A; Kovalev, A; Kowalkowski, J B; Kraus, J; Kravchenko, I V; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kumar, A; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lamore, D; Lancaster, J; Lancaster, M; Lander, R; Lanfranco, G; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lee, J; Lee, K; Lee, S W; Lei, C M; Leininger, M; Leonardi, G L; Leonardo, N; Leone, S; Levshina, T; Lewis, F; Lewis, J D; Li, K; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lobban, O; Lockyer, N S; Loginov, A; Loken, J; Loreti, M; Loskot, J; Loverre, P F; Lucchesi, D; Lukens, P; Lutz, P; Lyons, L; Lys, J; MacNerland, J; MacQueen, D; Madorsky, A; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Mammini, P; Manca, G; Mandrichenko, I V; Manea, C; Marginean, R; Marrafino, J; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mayer, J; Mayers, G M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Meyer, A; Miao, T; Michael, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Mizicko, D; Moccia, S; Moggi, A; Moggi, N; Montero, S; Moore, R; Moore, T; Morris, L; Morsani, F; Moulik, T; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Murgia, S; Nachtman, J; Nagaslaev, V; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Neuberger, D; Newby, W; Newcomer, F M; Newman-Holmes, C; Niell, F; Nielsen, J; Nicollerat, A S; Nigmanov, T; Niu, H; Nodulman, L; Noe, W; Österberg, K; Ogawa, T; Oh, S; Oh, Y D; Ohl, K; Ohsugi, T; Oishi, R; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Orr, S; Pagani, G; Pagliarone, C; Palmonari, F; Ramos, I; Panacek, S; Pantano, D; Paoletti, R; Papadimitriou, V; Pasetes, R; Pashapour, S; Passuello, D; Paterno, M; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pavlicek, V; Pavlon, S; Pellett, D; Penzo, Aldo L; Perington, B; Petragnani, G; Petravick, D; Phillips, T J; Photos, F; Piacentino, G; Picciolo, C; Piccoli, L; Piedra, J; Pitts, K T; Plunkett, R; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Profeti, A; Pronko, A G; Proudfoot, J; Punzi, G; Rademacker, J; Rafaelli, F; Rakitine, A; Rappoccio, S; Ratnikov, F; Rauch, J; Ray, H; Rechenmacher, R; Reia, S; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Riveline, M; Rivetta, C; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Román, M; Rosenberg, S I; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Sabik, S; Sadler, L; Safonov, A; Saint-Denis, R; Sakumoto, W K; Saltzberg, D; Sánchez, C; Sanders, H; Sanders, R; Sandrew, M; Sansoni, A; Santi, L; Sarkar, S; Sarraj, H; Sarraj, J; Sato, H; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, J; Schmidt, M P; Schmitt, M; Schmitt, R; Schmitz, M; Schofield, G L; Schuh, K; Schultz, K; Scodellaro, L; Scott, L; Scribano, A; Scuri, F; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shallenberger, J; Shapiro, M D; Shaw, T; Shears, T G; Shenai, A; Shepard, P F; Shimojima, M; Shochet, M J; Shon, Y; Shoun, M; Sidoti, A; Siegrist, J L; Sieh, C; Siket, M; Sill, A; Silva, R; Simaitis, V; Sinervo, P; Sirotenko, V I; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Stadie, H; Stanek, R; Stanfield, N; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Stuermer, W; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Syu, J; Szymulanski, A; Taffard, A C; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tamburello, P; Tanaka, M; Tanaka, R; Tang, D; Tanimoto, N; Tannenbaum, B; Tapprogge, Stefan; Taylor, R D; Teafoe, G; Tecchio, M; Teng, P K; Terashi, K; Terentieva, T; Tesarek, R J; Tether, S; Thom, J; Thomas, A; Thompson, A S; Thomson, E; Thurman-Keup, R M; Timm, S; Tipton, P; Tkaczyk, S M; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torretta, D; Trimby, C; Trischuk, W; Trumbo, J; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, T; Van Berg, R; Varganov, A V; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vittone, M; Voirin, J; Vollmer, B; Vollrath, I; Volobuev, I P; Von der Mey, M; Votava, M; Wagner, R G; Wagner, R L; Wagner, W; Wallace, N; Walter, T; Walters, A; Wan, Z; Wandersee, A; Wang, M J; Wang, S M; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Weems, L; Wenzel, H; Wester, W; Whitehouse, B; Wickenberg, W; Wicklund, A B; Wicklund, E; Wigmans, R; Wike, C; Wilkes, T; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Wong, M; Worcester, M; Worland, R; Worm, S; Wright, T; Wu, J; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yarema, R J; Yeh, G P; Yi, K; Yocum, D R; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zalokar, M; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zimmerman, T; Zsenei, A; Zucchelli, S

    2003-01-01

    We present a measurement of the mass difference m(D+_s) - m(D+), where both the D+_s and D+ are reconstructed in the phi pi+ decay channel. This measurement uses 11.6 pb-1 of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be: 99.41 +- 0.38 (stat) +- 0.21 (syst) MeV/c^2.

  13. The path ahead for MD/PhD programs in Canada Commentary on Jones et al.

    Science.gov (United States)

    Rosenblum, Norman D

    2016-09-11

    The paper by Jones and colleagues, published in this edition of Clinical Investigative Medicine, contributes to our understanding of Canadian MD/PhD Programs. While there has been little published on this subject by the Canadian programs, themselves, this paper is the most recent in a series by leaders of the Clinical Investigator Trainee Association of Canada (CITAC). The authors are to be commended for their efforts and productivity.

  14. mdRNA-Seq analysis of marine microbial communities from the northern Red Sea

    Science.gov (United States)

    Hou, Shengwei; Pfreundt, Ulrike; Miller, Dan; Berman-Frank, Ilana; Hess, Wolfgang R.

    2016-01-01

    Metatranscriptomic differential RNA-Seq (mdRNA-Seq) identifies the suite of active transcriptional start sites at single-nucleotide resolution through enrichment of primary transcript 5′ ends. Here we analyzed the microbial community at 45 m depth at Station A in the northern Gulf of Aqaba, Red Sea, during 500 m deep mixing in February 2012 using mdRNA-Seq and a parallel classical RNA-Seq approach. We identified promoters active in situ for five different pico-planktonic genera (the SAR11 clade of Alphaproteobacteria, Synechococcus of Cyanobacteria, Euryarchaeota, Thaumarchaeota, and Micromonas as an example for picoeukaryotic algae), showing the applicability of this approach to highly diverse microbial communities. 16S rDNA quantification revealed that 24% of the analyzed community were group II marine Euryarchaeota in which we identified a highly abundant non-coding RNA, Tan1, and detected very high expression of genes encoding intrinsically disordered proteins, as well as enzymes for the synthesis of specific B vitamins, extracellular peptidases, carbohydrate-active enzymes, and transport systems. These results highlight previously unknown functions of Euryarchaeota with community-wide relevance. The complementation of metatranscriptomic studies with mdRNA-Seq provides substantial additional information regarding transcriptional start sites, promoter activities, and the identification of non-coding RNAs. PMID:27759035

  15. Structural and Dynamic Analysis on IDPs by Modified AWSEM-MD

    Science.gov (United States)

    Wu, Hao; Papoian, Garegin; Papoian Theoretical Biophysics Group Team

    Unlike globular proteins, intrinsically disordered proteins (IDPs) lack both secondary and tertiary structures and can play key roles in various biological processes, including transcriptional regulation, molecular recognition and cellular signaling. These functions can be potentially elucidated by structural heterogeneity of IDPs. Because of their flexibility and disordered nature, it has been difficult to investigate IDPs both computationally and experimentally. In particular, it is desirable to develop coarse-grained, yet accurate models of IDPs, such that simulations exploring sufficient conformational ensembles could be carried out within feasible times. To achieve this goal, we modified the associative memory, water mediated, structure and energy model (AWSEM-MD), which is typically used for folding of globular proteins or binding studies. We tested modified AWSEM-MD on several well-studied IDPs and found the transient secondary structure propensity is consistent with NMR experimental results. The rugged free energy landscapes obtained also show structural heterogeneity of these IDPs. Our proposed extension of AWSEM-MD may allow simulating a wider range of IDPs with high accuracy and computational efficiency.

  16. Agrobacterium tumefaciens-mediated transformation of a taxol-producing endophytic fungus, Cladosporium cladosporioides MD2.

    Science.gov (United States)

    Zhang, Peng; Liu, Ting-Ting; Zhou, Peng-Peng; Li, Shu-Tao; Yu, Long-Jiang

    2011-04-01

    In this study, an Agrobacteriurn tumefaciens-mediated transformation (ATMT) protocol was successfully developed for the genetic transformation of a taxol-producing fungus, Cladosporium cladosporioides MD2, and the co-cultivation conditions affecting the transformation efficiency were optimized. The optimal transformation conditions were that 1 ml of C. cladosporioides MD2 spore suspension (10(8) spores/ml) was mixed with an equal volume of A. tumefaciens cultures, which contained 400 μl of A. tumefaciens LBA4404 (OD(660) ≈ 0.6) and 600 μl LB medium that were used to make up difference in volume, and the mix cultures were supplemented with 300 μM acetosyringone (AS) and co-cultivated at 26°C and 50 rpm for 48 h. Stable transformants were obtained through analysis of the mitotic stability of inserted T-DNA and the presence of hygromycin resistance gene (hpt II). This study laid a fine groundwork for development of transgenic C. cladosporioides MD2 strains.

  17. Theoretical investigation of loratadine reactivity in order to understand its degradation properties: DFT and MD study.

    Science.gov (United States)

    Armaković, Stevan; Armaković, Sanja J; Abramović, Biljana F

    2016-10-01

    Antihistamines are frequently used pharmaceuticals that treat the symptoms of allergic reactions. Loratadine (LOR) is an active component of the second generation of selective antihistaminic pharmaceutical usually known as Claritin. Frequent usage of this type of pharmaceuticals imposes the need for understanding their fundamental reactive properties. In this study we have theoretically investigated reactive properties of LOR using both density functional theory (DFT) calculations and molecular dynamics (MD) simulations. DFT study is used for collecting information related to the molecule stability, structure, frontier molecular orbitals, quantum molecular descriptors, charge distribution, molecular electrostatic potential surfaces, charge polarization, and local reactivity properties according to average local ionization energy surfaces. Based on these results, N24 atom of pyridine ring and oxygen atom O1 were identified with nucleophilic nature. In order to collect the information necessary for the proposition of degradation compounds we also calculated bond dissociation energies (BDE) for hydrogen abstraction and single acyclic bonds as well. According to BDE, the oxidation is likely to occur in the piperidine and cycloheptane rings. MD simulations were used in order to understand the interactions with water through radial distribution functions (RDF). Based on RDFs the most important interactions with solvent are determined for carbon atom C5, chlorine atom Cl15, and oxygen atom O1. Collected results based on DFT calculations and MD simulations provided information important for suggestion of possible degradation compounds. Covalent and noncovalent interactions between LOR and (•)OH have also been investigated. PMID:27640160

  18. Cryptanalysis of Two MD5-Based Authentication Protocols: APOP and NMAC

    Science.gov (United States)

    Wang, Lei; Ohta, Kazuo; Sasaki, Yu; Sakiyama, Kazuo; Kunihiro, Noboru

    Many hash-based authentication protocols have been proposed, and proven secure assuming that underlying hash functions are secure. On the other hand, if a hash function compromises, the security of authentication protocols based on this hash function becomes unclear. Therefore, it is significantly important to verify the security of hash-based protocols when a hash function is broken. In this paper, we will re-evaluate the security of two MD5-based authentication protocols based on a fact that MD5 cannot satisfy a required fundamental property named collision resistance. The target protocols are APOP (Authenticated Post Office Protocol) and NMAC (Nested Message Authentication Code), since they or their variants are widely used in real world. For security evaluation of APOP, we will propose a modified password recovery attack procedure, which is twice as fast as previous attacks. Moreover, our attack is more realistic, as the probability of being detected is lower than that of previous attacks. For security evaluation of MD5-based NMAC, we will propose a new key-recovery attack procedure, which has a complexity lower than that of previous attack. The complexity of our attack is 276, while that of previous attack is 2100.**Moreover, our attack has another interesting point. NMAC has two keys: the inner key and the outer key. Our attack can recover the outer key partially without the knowledge of the inner key.

  19. Solvation structure and dynamics of Na+ in liquid ammonia studied by ONIOM-XS MD simulations

    Science.gov (United States)

    Sripradite, Jarukorn; Tongraar, Anan; Kerdcharoen, Teerakiat

    2015-12-01

    The molecular dynamics (MD) technique based on the ONIOM-XS method, known as the ONIOM-XS MD, has been applied to investigate the solvation structure and dynamics of Na+ in liquid ammonia. Regarding the ONIOM-XS MD results, it is observed that Na+ is able to order the surrounding ammonia molecules to form its specific first and second solvation shells with the average coordination numbers of 5.1 and 11.2, respectively. The first solvation shell of Na+ is rather well-defined, forming a preferred 5-fold coordinated complex with a distorted square pyramidal geometry. In this respect, the most preferential Na+(NH3)5 species could convert back and forth to the lower probability Na+(NH3)6 and Na+(NH3)4 configurations. The second solvation shell of Na+ is detectable, in which a number of ammonia molecules, ranging from 7 to 14, are involved in this layer and they are arranged according to recognizable influence of the ion.

  20. Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

    Directory of Open Access Journals (Sweden)

    Aruna Rajan

    Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

  1. 试论MD5算法的安全分析及破解

    Institute of Scientific and Technical Information of China (English)

    马珂

    2014-01-01

    本文介绍了MD5加密算法原理及利用MD5加密算法保护网络上传输的用户登录信息以及破译算法,并介绍了差分的引入原则,分析了MD5算法迭代中差分路径的方法,利用非线性函数的性质和差分的扩展来引导中间差分的继承、产生和消除。

  2. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    首先介绍了MD5算法的概念,然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  3. MD5防碰撞和穷举变换算法的研究与实现

    Institute of Scientific and Technical Information of China (English)

    刘红军

    2008-01-01

    分析MD5加密算法和碰撞的原理,对目前常规MD5算法加密结果容易被破解的问题,在java. security包提供的MD5算法基础上给出了多种变换算法,以进一步减小破解时的碰撞概率,增强系统加密的安全性.

  4. 关于MD5算法的分析及其性能优化

    Institute of Scientific and Technical Information of China (English)

    崔永辉; 徐鹏; 阳征鹏

    2015-01-01

    本文主要介绍了MD5算法的实现原理和对源数据信息的加密流程,然后从算法实现的角度,依据当前CPU计算机制,对MD5算法的计算时间的消耗进行分析,并提出了相应的性能优化建议,从而提升MD5算法的计算速度。

  5. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Science.gov (United States)

    Vu, Le Anh; Hoa, Duong Quang

    2009-03-01

    The present paper is a continuation of [13], [14] of the authors. Specifically, the paper considers the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideal. In the paper, we give the topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of $\\mathbb{R}^{2}$ and the Connes' C*-algebras of the foliations which come from fibrations are also given in the paper.

  6. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R

    Directory of Open Access Journals (Sweden)

    John Grable

    2014-08-01

    Full Text Available John E. Grable, Ph.D., CFP(R teaches and conducts research in the Certified Financial Planner(TM Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research interests include financial risk-tolerance assessment, psychophysiological economics, and financial planning help-seeking behavior. Dr. Grable has published nearly 100 peer-reviewed papers, co-authored two financial planning textbooks, and co-edited a financial planning and counseling scales book. He currently writes a quarterly column for the Journal of Financial Service Professionals, serves as academic consultant to the Journal of Financial Planning, and chair the CFP Board Council on Education.

  7. Frizzled to finance: one PhD's path from a Drosophila lab to Wall Street.

    Science.gov (United States)

    Taylor, Job

    2016-06-01

    An equity research analyst's job is to determine whether the price of a stock is likely to go up or down. For science-based businesses, particularly biotechnology companies, a PhD in the life sciences can be very helpful in making this determination. I transitioned from a postdoc position to working in equity research. Here I present information on how I made the transition, an overview of the day-to-day activities of an analyst, and thoughts on how to prepare to look for a job in finance. There are significant positives to working on Wall Street, including exposure to cutting-edge clinical/translational research, access to some of the best scientists in the world, a dynamic work environment, and compensation that generally exceeds academic salaries. This comes at the cost of some independence and the satisfaction of being able to call oneself a scientist. PMID:27235096

  8. Mark Plotkin, PhD: in search of plants that heal. Interview by Bonnie Horrigan.

    Science.gov (United States)

    Plotkin, M

    1996-03-01

    Ethnobotantist Mark Plotkin, PhD, spent much of the last decade in the rain forests of South America, learning about curative plants and medical practices from the tribal shamans. Through his work with indigenous people in Brazil, French Guiana, Suriname, and Venezuela, he has categorized more than 300 shaman plant cures. Plotkin studied ethnobotany at Harvard, Yale, and Tufts, and is the first botanist to receive the San Diego Zoological Society's Conservation Medal. He previously served as director of plant conservation at the World Wildlife Fund, the world's largest conservation organization, and as vice president of Conservation International. Founder of the "Shaman's Apprentice Program," which encourages younger tribal members to apprentice under the aging shamans, Plotkin currently devotes his time to curative plant research, consultation, lecturing, writing, and fund raising for his new organization, the Conservation and Ethnobiology Alliance. He has published numerous scientific articles and is the author of the popular book, Tales of a Shaman's Apprentice. PMID:8795891

  9. Frizzled to finance: one PhD's path from a Drosophila lab to Wall Street.

    Science.gov (United States)

    Taylor, Job

    2016-06-01

    An equity research analyst's job is to determine whether the price of a stock is likely to go up or down. For science-based businesses, particularly biotechnology companies, a PhD in the life sciences can be very helpful in making this determination. I transitioned from a postdoc position to working in equity research. Here I present information on how I made the transition, an overview of the day-to-day activities of an analyst, and thoughts on how to prepare to look for a job in finance. There are significant positives to working on Wall Street, including exposure to cutting-edge clinical/translational research, access to some of the best scientists in the world, a dynamic work environment, and compensation that generally exceeds academic salaries. This comes at the cost of some independence and the satisfaction of being able to call oneself a scientist.

  10. Preliminary and Partial Inventory of PhD Theses and their Authors

    Directory of Open Access Journals (Sweden)

    Coordinators TRI's National Network

    2013-04-01

    Full Text Available The mission statement of the Terrorism Research Initiative (TRI is “Enhancing Security through Collaborative Research”. TRI has been encouraging young scholars who are in the process of writing their PhD theses to link up and collaborate with fellow researchers in their own countries. As a result, post-graduate students have begun to interact for their own mutual benefit and for the good of the wider research community. In fact, in a number of cases several senior, post-doctoral scholars have also joined TRI’s national networks of those studying terrorism, political violence and armed conflict, and ways to prevent and counter such threats to human security. 

  11. PhD students at Science & Technology exploring student learning in a collaborative video-circle

    DEFF Research Database (Denmark)

    Nielsen, Birgitte Lund; Hougaard, Rikke F.

    to facilitate students' exploratory talk in small class teaching, lab exercises etc. A potential third module organized as a video-circle with collaborative analysis of the TAs teaching based on observation and video has therefore been tested. The TAs reflections and their enactments in own teaching have been......A teaching course for PhD students at Science & Technology, Aarhus University, working as Teaching Assistants (TAs) has been iteratively developed to have two consecutive modules. Role-plays at course days and a "teaching in practice" assignment between modules have indicated that the TAs struggle...... of seeing peers teach and getting feedback from professionals. In addition they appreciated the equal atmosphere in the group. there are indications that the TAs focused on student learning by consciously supporting students' exploratory talk in their new enactments. Parts of the TAs reflections...

  12. Trends in Ph.D. Productivity and Diversity in Top-50 U.S. Chemistry Departments: An Institutional Analysis

    Science.gov (United States)

    Laursen, Sandra L.; Weston, Timothy J.

    2014-01-01

    The education of doctoral chemists contributes to the chemical research enterprise and thus to innovation as an engine of the economy. This quantitative analysis describes trends in the production and diversity of chemistry Ph.D. degrees in the top-50 U.S. Ph.D.-granting departments in the past two decades. Time series data for individual…

  13. Device interoperability and authentication for telemedical appliance based on the ISO/IEEE 11073 Personal Health Device (PHD) Standards.

    Science.gov (United States)

    Caranguian, Luther Paul R; Pancho-Festin, Susan; Sison, Luis G

    2012-01-01

    In this study, we focused on the interoperability and authentication of medical devices in the context of telemedical systems. A recent standard called the ISO/IEEE 11073 Personal Health Device (X73-PHD) Standards addresses the device interoperability problem by defining common protocols for agent (medical device) and manager (appliance) interface. The X73-PHD standard however has not addressed security and authentication of medical devices which is important in establishing integrity of a telemedical system. We have designed and implemented a security policy within the X73-PHD standards. The policy will enable device authentication using Asymmetric-Key Cryptography and the RSA algorithm as the digital signature scheme. We used two approaches for performing the digital signatures: direct software implementation and use of embedded security modules (ESM). The two approaches were evaluated and compared in terms of execution time and memory requirement. For the standard 2048-bit RSA, ESM calculates digital signatures only 12% of the total time for the direct implementation. Moreover, analysis shows that ESM offers more security advantage such as secure storage of keys compared to using direct implementation. Interoperability with other systems was verified by testing the system with LNI Healthlink, a manager software that implements the X73-PHD standard. Lastly, security analysis was done and the system's response to common attacks on authentication systems was analyzed and several measures were implemented to protect the system against them.

  14. Standard-compliant real-time transmission of ECGs: harmonization of ISO/IEEE 11073-PHD and SCP-ECG.

    Science.gov (United States)

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2009-01-01

    Ambient assisted living and integrated care in an aging society is based on the vision of the lifelong Electronic Health Record calling for HealthCare Information Systems and medical device interoperability. For medical devices this aim can be achieved by the consistent implementation of harmonized international interoperability standards. The ISO/IEEE 11073 (x73) family of standards is a reference standard for medical device interoperability. In its Personal Health Device (PHD) version several devices have been included, but an ECG device specialization is not yet available. On the other hand, the SCP-ECG standard for short-term diagnostic ECGs (EN1064) has been recently approved as an international standard ISO/IEEE 11073-91064:2009. In this paper, the relationships between a proposed x73-PHD model for an ECG device and the fields of the SCP-ECG standard are investigated. A proof-of-concept implementation of the proposed x73-PHD ECG model is also presented, identifying open issues to be addressed by standards development for the wider interoperability adoption of x73-PHD standards.

  15. Assessment Procedures of Norwegian PhD Theses as Viewed by Examiners from the USA, the UK and Sweden

    Science.gov (United States)

    Kyvik, Svein

    2014-01-01

    This article focuses on the assessment procedures of Norwegian PhD theses as viewed by external members of evaluation committees from three countries with different examination systems; the USA, the UK and Sweden. Their viewpoints give useful information not only on the pros and cons with the Norwegian system, but also on the strengths and…

  16. PhD Topic Arrangement in "D"iscourse Communities of Engineers and Social Sciences/Humanities

    Science.gov (United States)

    Hasrati, Mostafa; Street, Brian

    2009-01-01

    This article is the result of a grounded theory investigation into the ways PhD topics are assigned by supervisors in engineering and selected by students in the social sciences/humanities in UK universities, broadly referred to as "topic arrangement", which can be regarded as one aspect of academic socialisation into academic Discourse…

  17. Who Am I versus Who Can I Become? Exploring Women's Science Identities in STEM Ph.D. Programs

    Science.gov (United States)

    Szelényi, Katalin; Bresonis, Kate; Mars, Matthew M.

    2016-01-01

    This article explores the science identities of 21 women STEM Ph.D. students at three research universities in the United States. Following a narrative approach, the findings depict five salient science identities, including those of a) academic, b) entrepreneurial, c) industrial, and d) policy scientist and e) scientist as community educator. Our…

  18. On the Importance of PhD Institute in Establishing a Long-Term Research Career in Astronomy

    CERN Document Server

    Gibson, B K; Vassiliadis, E; Sevenster, M N; Jones, D H; Thornberry, R K; Gibson, Brad K.; Buxton, Michelle; Vassiliadis, Emanuel; Sevenster, Maartje N.; Thornberry, Rebecca K.

    1999-01-01

    We have examined the success rates of 19 American, Canadian, Australian, and Dutch graduate programs in producing astronomers. A 20-year baseline was considered (1975-1994), incorporating 897 PhD recipients. The major conclusion from our study is that the fraction of PhD graduates still involved in astronomical research is surprisingly insensitive to the institutional source of one's PhD. With few exception, 55-75% of graduates, regardless of PhD source, remain active in the astronomical research community. While it remains true that graduates of so-called ``prestigious'' programs preferentially populate the same, it is also clear that an abundance of opportunities exist at smaller ``non-prestigious'' institutions, liberal arts colleges, government, and industry. The latter, of course, generally carry enhanced administrative and/or teaching duties, but, on the other hand, do not entirely preclude a role in the research community. A Kepler-Meier survival analysis of two disparate institutes demonstrates that `...

  19. PhD Students' Experiences of Thesis Supervision in Malaysia: Managing Relationships in the Midst of Institutional Change

    Science.gov (United States)

    Krauss, Steven Eric; Ismail, Ismi Arif

    2010-01-01

    Despite the plethora of studies that have been conducted on PhD supervision, little qualitative investigation has been conducted with a diverse, non-Western sample of doctoral students in an attempt to understand how the supervisory relationship is experienced. In response, eighteen students from diverse, non-Western backgrounds studying at one…

  20. A Study on Changes of Supervision Model in Universities and Fostering Creative PhD Students in China

    DEFF Research Database (Denmark)

    Luo, Lingling; Zhou, Chunfang; Zhang, Song

    2015-01-01

    This paper aims to explore the changes of supervision model in higher education in relation to fostering creative Ph.D. students in China. The changes are being made from the traditional Apprentice Master Model (AMM) to the modern Collaborative Cohort Model (CCM). According to the results of the...... also explores the reason of why the mechanism failed to play fully....