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Sample records for burke md phd

  1. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  2. Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

    Science.gov (United States)

    Topper, James N; Rutherford, John D

    2016-11-15

    Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

  3. "Academic racism" and the neglected scholarship of the anatomist M. Wharton Young, MD, PhD (1904-1986).

    Science.gov (United States)

    Heywood, Peter

    2016-01-12

    Moses Wharton Young, MD, PhD (1904-1986), was an African American Professor of Neuroanatomy at Howard University College of Medicine from 1934 to 1973, during which time he authored about 100 publications on topics that included baldness, asthma, glaucoma, and, most importantly, the structure and function of the inner ear and the pathophysiology of blast injuries. Much of Young's research was ignored during his lifetime, raising the question whether this professional neglect was an instance of "academic racism." © IMechE 2016.

  4. Book review of "The Ethics of Coercion in Mass Casualty Medicine" by Griffin Trotter MD, PhD

    Directory of Open Access Journals (Sweden)

    Singh Sonal

    2007-10-01

    Full Text Available Abstract Public health ethics is neither taught widely in medical schools or schools of public health in the US or around the world. It is not surprising that health care professionals are particularly challenged when faced with ethical questions which extend beyond safeguarding the interests of their individual patients to matters that affect overall public good. The perceived threat of terror after September 11 2007, the anthrax attacks and the Katrina debacle are recent circumstances which may result in coercion. These have piqued the interest of medical professionals and the general public on public health ethics. The Ethics of Coercion in Mass Casualty Medicine written by Griffin Trotter MD, PhD attempts to fill a timely void in this area by examining the ethics of coercion in times of public health disasters.

  5. Bernard Schwartz, MD, PhD, Founding Chair of Ophthalmology, Tufts University School of Medicine, and Founding Editor of Survey of Ophthalmology.

    Science.gov (United States)

    Hedges, Thomas R

    2009-01-01

    Bernard Schwartz, MD, PhD (1927-2007) was first and foremost a scholar. He was a teacher, serving as Professor of ophthalmology for many years at Tufts University; an administrator, chairing the department of ophthalmology for over 20 years; a clinician, practicing primarily in the field of glaucoma; a scientist with a broad interest in ophthalmic research; an historian, especially of medical history; and an editor, primarily of Survey of Ophthalmology. Throughout all of his activities, the central theme was always scholarship.

  6. Teaching Burke Using Advertisements.

    Science.gov (United States)

    Larson, Charles U.

    Kenneth Burke's concepts of identification, the five terms of dramatism, and strategic uses of ambiguity can be successfully taught to undergraduates if appropriate and familiar examples are used. Print and electronic advertising offer the instructor an up-to-date, familiar, and abundant source of classroom examples. Market segmentation models…

  7. Teaching Burke: Kenneth Burke and the Rhetoric of Ascent.

    Science.gov (United States)

    Quinn, Arthur

    1995-01-01

    Advises that in teaching Kenneth Burke it is important that students understand that his strength is not what Richard Rorty calls systematic reasoning but rather edification. Shows how Burke, like Thomas Carlyle, is prophet or sage who sketches out a Romantic world view. (TB)

  8. Rencontres autour de Peter Burke

    OpenAIRE

    Guillorel, Eva

    2015-01-01

    [Textes rassemblés par Eva Guillorel]; Publication en ligne du CRHQ - Il s'agit du Cahier n°5 du CRHQ intitulé : Rencontres autour de Peter Burke. Le cahier n°5 du CRHQ est en ligne à l'adresse suivante : http://www.crhq.cnrs.fr/cahiers/page-cahier.php?id_num=10 consulté le 24/09/2015.Les textes qui composent cette cinquième livraison des Cahiers du CRHQ sont issus d'une semaine de conférences et débats organisée autour de l'invitation de Peter Burke à l'Université de Caen Basse-Normandie ent...

  9. Obituary: Edward W. Burke, Jr. (1924-2011)

    Science.gov (United States)

    Bloomer, Raymond, Jr.

    2011-12-01

    Dr. Edward W. Burke Jr. passed away on June 15, 2011, after suffering a heart attack. Dr. Burke devoted his professional life to the research and teaching of physics and astronomy at King College in Bristol, Tennessee. Edward W. Burke, Jr., was born in Macon, Georgia, on September 16, 1924. He was a Navy veteran, having been commissioned as an ensign in 1944. He served in the Pacific near the end of World War II. He proceeded to complete his undergraduate degree in mathematics from Presbyterian College in 1947 and pursued the M.S. and Ph.D. in physics (1949 and 1954, respectively) at the University of Wisconsin. Under the direction of Professor Julian Mack, his thesis was titled "Isotope Shift in the Spectra of Boron." Although he did research in atomic spectra in the early part of his career, his interest in astronomy and variable stars in particular were his primary interests during his long academic career. Dr. Burke began his illustrious career at King College in 1949. He initiated the astronomy program there in 1950, included constructing a 12.5 inch Newtonian telescope, homemade as was most everything in those days. Many of his students learned about photometry at the Burke Observatory on the college campus. Burke was known for his trips to the Kitt Peak and Lowell observatories accompanied by undergraduate students on his trips, all of which were made by automobile which he preferred over flying. His initial interest in Ap stars later broadened into variable and especially eclipsing binary stars. His motivation was maintained by his desire to have his students experience basic research and to spark their interest in advanced degrees. Numerous students achieved advanced science and medical degrees because of Burke's encouragement and mentoring. In 1959, Dr. Burke was awarded a Fulbright professorship and traveled to Chile where he taught physics for a year in the Engineering School at the University of Chile in Santiago. He worked to establish a physics

  10. Antithetical Ethics: Kenneth Burke and the Constitution.

    Science.gov (United States)

    Anderson, Virginia

    1995-01-01

    Shows how the textuality of the United States Constitution, the most venerable of classic democratic icons, might be exploited to nurture postmodern ethics. Shows how Kenneth Burke's reading of the Constitution accords with and augments the postmodern theories of J.-F. Lyotard and S. Jarratt. Discusses a postmodern Constitution and the…

  11. Nietzsche contra Burke: The Melodrama in Dramatism.

    Science.gov (United States)

    Desilet, Gregory

    1989-01-01

    Examines Kenneth Burke's and Friedrich Nietzsche's similar understanding of the hortatory nature of language-using, weighed against their radically differing conceptions of the negative, which allows a distinction between two genres of dramatism, and illustrates contrasting orientations toward symbolic activity in general. (SR)

  12. Intercultural Communication Research: A Burke's Eye View.

    Science.gov (United States)

    Jones, Tricia S.

    Kenneth Burke's concepts of rhetoric, dramatism, terministic screens (perceptual filters), and identification are used in this paper to justify and direct intercultural communication research. Three intercultural methodologies--cultural variable analysis, componential analysis, and ethnomethodology--are examined in the paper using these concepts.…

  13. Md Naimuddin

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Md Naimuddin. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1255-1258 Poster Presentations. Model unspecific search for new physics in collision at √s=7 TeV · Shivali Malhotra Md Naimuddin Thomas Hebbeker Arnd Meyer ...

  14. Metadata (MD)

    Science.gov (United States)

    Robert E. Keane

    2006-01-01

    The Metadata (MD) table in the FIREMON database is used to record any information about the sampling strategy or data collected using the FIREMON sampling procedures. The MD method records metadata pertaining to a group of FIREMON plots, such as all plots in a specific FIREMON project. FIREMON plots are linked to metadata using a unique metadata identifier that is...

  15. 78 FR 59955 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-09-30

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park Service, Interior. ACTION: Notice; correction. SUMMARY: The Thomas Burke Memorial Washington State Museum, University of Washington (Burke...

  16. 77 FR 51564 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-24

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington, has completed an... contact the Burke Museum. Repatriation of the human remains to the tribe named below may occur if no...

  17. 78 FR 11675 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-02-19

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum... Thomas Burke Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains... believes itself to be culturally affiliated with the human remains may contact the Burke Museum...

  18. Retraction Statement: "Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL" by Xue Li, MMed, Dong Li, PhD, Yong Zhuang, MMed, Qing Shi, BSc, Wei Wei, MMed, and Xiuli Ju, MD, PhD.

    Science.gov (United States)

    2017-05-01

    The above article, published online 23 August 2013 in Pediatric Blood and Cancer, Volume 60, Issue 12, December 2013, Pages 2060-2067, has been retracted by agreement among the authors, the journal's Editor-in-Chief, Peter E. Newburger, M.D., and Wiley Periodicals, Inc. The decision to retract was agreed upon following notification that the paper substantially duplicates a prior study already published in Chinese https://www.ncbi.nlm.nih.gov/pubmed/23611221. The authors were not aware that publication in another language would constitute a duplicate publication and, upon being informed of this fact, have agreed to withdraw the paper from Pediatric Blood and Cancer. Reference Li X, Li D, Zhuang Y, Shi Q, Wei W and Ju X. Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL. Pediatr Blood Cancer. 2013; 60: 2060-2067. doi:10.1002/pbc.24583. © 2017 Wiley Periodicals, Inc.

  19. Kuidas kirjutatakse ajalugu? / Peter Burke ; interv. Marek Tamm, tlk. Ainiki Väljataga

    Index Scriptorium Estoniae

    Burke, Peter

    2007-01-01

    Renessansiajastu kultuuriloost, keelest sotsiaalajaloo uurimisobjektina ning ajalookirjutuse ajaloost ja teooriast Cambridge'i Ülikooli kultuuriajaloo emeriitprofessoti P. Burke'i teostes. Varem ilm.: Burke, Peter. Kultuuride kohtumine : esseid uuest kultuuriajaloost. Tallinn, 2006. Lk. 275-286

  20. Burke, Nietzsche, Lacan: Three Perspectives on the Rhetoric of Order.

    Science.gov (United States)

    Thomas, Douglas

    1993-01-01

    Examines the complex relationship between rhetoric and order in the works of Kenneth Burke, Friedrich Nietzsche, and Jacques Lacan. Argues for three differing, yet complementary, views of rhetoric and order, each having a corresponding epistemology and axiology. Concludes with an analysis of the construction of order in Thomas Hobbe's…

  1. "Verbal Atom Cracking": Burke and a Rhetoric of Reading.

    Science.gov (United States)

    Enos, Theresa

    "Verbal atom cracking," according to Kenneth Burke, entails a process where the reader reconstructs what the writer has constructed--a necessary process before the reader can begin deconstructing. Foregrounding opposites, rather than looking for apposites, may not be the best way to approach discourse that covers especially esoteric…

  2. Division, Unity, and Consciousness Raising: Burke and Ong on Technology.

    Science.gov (United States)

    Palmeri, Anthony J.

    In an effort to contribute to the dialogue on the effects of the intensification of technology upon the structure and dynamics of human communication, this paper examines the views of technology in the works of Kenneth Burke and Walter Ong. The paper argues that their theories can be compatible, that Ong's view of writing as a technology which…

  3. 78 FR 64006 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-10-25

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum, University of Washington (Burke Museum), has completed an...

  4. Fincher-Burke excitations in single-Q chromium

    CERN Document Server

    Böni, P; Stadler, C; Roessli, B; Shirane, G; Werner, S A

    2002-01-01

    The low-energy excitations of incommensurate antiferromagnetic Cr have been investigated by means of high-resolution, inelastic neutron scattering with unpolarized, cold neutrons within an energy range E<9 meV. In agreement with previous measurements we observe Fincher-Burke excitations in the transverse spin density wave phase that appear between the unresolved spin-wave peaks at the incommensurate positions Q sup+-=(1+- delta,0,0). In contrast to the previous measurements, our high-resolution data shows that the Fincher-Burke modes do not follow a linear dispersion. Therefore, they have nothing in common with the acoustic phonon branch. The major part of the scattering is concentrated in the range 4 meV

  5. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash funct...

  6. Injector MD Days 2017

    CERN Document Server

    Rumolo, G

    2017-01-01

    The Injector Machine Development (MD) days 2017 were held on 23-24 March, 2017, at CERN with thefollowing main goals:Give a chance to the MD users to present their results and show the relevant progress made in 2016 onseveral fronts.Provide the MD users and the Operation (OP) crews with a general overview on the outcome and theimpact of all ongoing MD activities.Identify the open questions and consequently define - with priorities - a list of machine studies in theinjectors for 2017 (covering the operational beams, LHC Injectors Upgrade, High Luminosity LHC,Physics Beyond Colliders, other projects).Create the opportunity to collect and document the highlights of the 2016 MDs and define the perspectivesfor 2017.Discuss how to make best use of the MD time, in particular let the main MD user express their wishesand see whether/how OP teams can contribute to their fulfilment.

  7. Md Maidul Islam

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Md Maidul Islam. Articles written in Journal of Chemical Sciences. Volume 122 Issue 2 March 2010 pp 247-257 Full Papers. DNA minor groove binding of small molecules: Experimental and computational evidence · Prateek Pandya Md Maidul Islam G Suresh Kumar B ...

  8. 75 FR 36672 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. Notice is here.... 3003, of the completion of an inventory of human remains in the possession of the Thomas Burke Memorial...

  9. "More Than Lessons in How To Read": Burke, Freud, and the Resources of Symbolic Transformation.

    Science.gov (United States)

    Quandahl, Ellen

    2001-01-01

    Argues that Kenneth Burke used "The Interpretation of Dreams," as well as other works by Sigmund Freud, as a lesson on reading, taking over the central tropes of dreamwork and making them broadly dialectical rather than strictly psychoanalytic terms. Suggests that Freud's "tropology" of dreaming is crucial for reading Burke.…

  10. 77 FR 46117 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-02

    ...-1100-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of... Memorial Washington State Museum (Burke Museum) has completed an inventory of human remains and associated... Museum. Disposition of the human remains and the associated funerary object to the Indian tribes stated...

  11. 75 FR 5105 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-02-01

    ... by David Munsell. The collection was transferred from the University of Washington Anthropology...-human bone, stone, and shell; 1 lot plant material mixed with human bone; 1 lot stone; and 26 level bags... Anthropology Department to the Burke Museum in the 1970s, and was formerly accessioned in 1996 (Burke Accn...

  12. MD plans in 2012

    OpenAIRE

    Assmann, R

    2012-01-01

    Machine development sessions were performed in 2011 during dedicated slots of beam time. These MD studies were scheduled and planned in detail well before, reflecting the agreed priorities: further optimizing machine performance, exploring beam parameters beyond design targets, assessing machine limitations, testing new concepts and machine settings. The MD's in 2012 will build on the successful 2011 experience. The proposed priorities are discussed. A particular emphasis is put on how to bes...

  13. Approaching Corporate Social Responsibility through Kenneth Burke's Notions of Terministic Screens and Entitlement

    DEFF Research Database (Denmark)

    Kampf, Constance

    summarizes Burke's essay, "Antinomies of Definition," from a Grammar of Motives as demonstrating that 'the intrinsic and the extrinsic can change places' "such that to define is always to contextualize and to uncover the absence of a solid ground for a claim to knowledge."2   So if the intrinsic......). "Screening Symbolicity." in Henderson & Williams, eds. Unending Conversations: New Writings by and about Kenneth Burke. Southern Illinois University Press: Carbondale. p.146....

  14. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2009-12-01

    Full Text Available Report of PhD Dissertations. Gianmarco Cossandi Gli statuti di Novara nel XIV secolo. Studio ed edizione della legislazione di Giovanni e di Galeazzo II Visconti, tesi di dottorato in Storia medievale (XVII ciclo, Università Cattolica del Sacro Cuore di Milano, 2006   Anna Elisa Carrisi Ostuni nel XV secolo. Istituzioni e società, Tesi di dottorato in Il Mezzogiorno tra Europa e Mediterraneo: territorio, istituzione e società del medioevo all’età contemporanea (XX ciclo, Università del Salento, 2008

  15. Geology and paleontology of five cores from Screven and Burke counties, eastern Georgia

    Science.gov (United States)

    Edwards, Lucy E.

    2001-01-01

    Five deep stratigraphic test holes were drilled from 1991 to 1993 in support of multidisciplinary investigations to determine the stratigraphy of Upper Cretaceous and Tertiary sediments of the coastal plain in east-central Georgia. Cored sediment and geological logs from the Millhaven test hole in Screven County and the Girard and Millers Pond test holes in Burke County are the primary sources of lithologic and paleontologic information from this report. Lithologic and paleontologic information from the Thompson Oak and McBean test holes in Burke County supplements the discussion of stratigraphy and sedimentation in the updip part of the study area near the Millers Pond test hole.

  16. Debate on sublime in the end of 18th century: Burke, Kant, Schiller

    Directory of Open Access Journals (Sweden)

    Jeremić-Molnar Dragana

    2009-01-01

    Full Text Available In the article the authors are examining three positions within the 18th Century aesthetic discussion on the sublime - Edmund Burke's, Immanuel Kant's and Friedrich Schiller's. They are also trying to reconstruct the political backgrounds of each of this theoretical positions: old regime conservatism (Burke, republican liberalism (Schiller and romantic longing for the 'third way' (Kant. The most sophisticated and mature theory of sublime is found in Schiller's aesthetic works, especially in those following his disappointment in French Revolution, in which the relationship between sublime and paradoxes of historical violence is most thoroughly reflected.

  17. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-06-01

    Full Text Available Reporto of PhD Dissertations.   Mario Dalle Carbonare Società, potere e clientele nell’Irlanda altomedievale (secoli V-IX, Tesi di dottorato di ricerca in Storia sociale europea, Università "Ca' Foscari" di Venezia, 2003 Vieri Mazzoni La legislazione antighibellina e la politica oligarchica della Parte Guelfa di Firenze nel secondo Trecento (1347-1378, Tesi di dottorato di ricerca in Storia Medievale (ciclo XII, Università degli Studi di Firenze   Alma Poloni Pisa dalle origini del movimento popolare alla discesa di Ludovico il Bavaro. I gruppi dirigenti cittadini tra continuità e trasformazione, Tesi di dottorato di ricerca in Storia dell'Europa nel medioevo, Università degli studi di Pisa, 2003   Andrea Puglia Potere marchionale, amministrazione del territorio, società locali dalla morte di Ugo di Tuscia a Guelfo VI di Baviera (1001-1160, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Milano, 2003

  18. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2010-06-01

    Full Text Available Report of PhD dissertations. Andrea Brugnoli Una storia locale: l’organizzazione del territorio veronese nel medioevo: trasformazioni della realtà e schemi notarili (IX-metà XII secolo, Tesi di dottorato di ricerca in Scienze Storiche e Antropologiche (XXII ciclo, Università degli Studi di Verona, 2010   Luca Filangieri Famiglie e gruppi dirigenti a Genova (secoli XII-metà XIII, Tesi di dottorato di ricerca in Storia medievale (XXII ciclo, Università degli Studi di Firenze, 2010   Jakub Kujawi ski Wernakularna kolekcja historiograficzna z rękopisu francuskiego nr 688 z Biblioteki Narodowej w Paryżu. Studium źródłoznawcze (La raccolta dei volgarizzamenti delle opere storiografiche nel manoscritto francese 688 della Biblioteca Nazionale di Parigi, Tesi di dottorato, Università “Adam Mickiewicz”, Facoltà di Storia, Pozna, a.a. 2009/2010   Marta Longhi I signori “de Radicata”. Strategie di affermazione familiare e patrimoniale nel Piemonte dei secoli XII-XIV, Tesi di dottorato di ricerca in Istituzioni, Società, Religioni dal Tardo Antico alla fine del Medioevo (XX ciclo, Università di Torino, 2008

  19. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available Report of PhD Dissertations. Francesco Barone Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Laura Berti Ceroni Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.   Marco Bicchierai Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004   Emanuela Garimberti Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Lorenzo Tanzini Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Stefania Tarquini Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

  20. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003

  1. One Hundred Years of Reading Research: Successes and Missteps of Edmund Burke Huey and Other Pioneers

    Science.gov (United States)

    Walczyk, Jeffrey J.; Tcholakian, Talar; Igou, Frank; Dixon, Alexa P.

    2014-01-01

    For more than 100 years, research on the psychology of reading has proliferated. In this article, the authors wish to help modern reading researchers understand the origins of the discipline and benefit from its history. This article draws heavily on Edmund Burke Huey's 1908 landmark volume "The Psychology and Pedagogy of Reading,"…

  2. 75 FR 36671 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park Service, Interior. ACTION: Notice... Act (NAGPRA), 25 U.S.C. 3003, of the completion of an inventory of human remains and associated...

  3. Ronald Reagan on Lebanon and Grenada: Flexibility and Interpretation in the Application of Kenneth Burke's Pentad.

    Science.gov (United States)

    Birdsell, David S.

    1987-01-01

    Analyzes President Reagan's foreign policy address of October 27, 1983, on events in Lebanon and Grenada, by taking a flexible approach to Kenneth Burke's "pentad"--preserving the inherent ambiguity of act, agent, agency, scene, and purpose. Concludes that the speech reveals a formulation of American character incompatible with a…

  4. Rhetorical Interpretation of Abstracts in Sci-Tech Theses Based on Burke's Identification Theory

    Science.gov (United States)

    Zhong, Jihong

    2017-01-01

    Abstract of a thesis is the brief and accurate representation of the thesis, with the important function of persuading readers to read on the thesis. So how the writer constructs the abstract and wins readers' recognition is our main focus. On the basis of Burke's Identification Theory, this paper analyzed 10 abstracts from "Nature" from…

  5. 77 FR 59649 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-09-28

    ... sites and are considered part of the Gulf of Georgia Culture Area. Material culture observed at the... with Native American Coast Salish material culture. Oral history indicates that Orcas Island was... transferred to the Burke Museum by the University of Washington Anthropology Department in 1991 and were...

  6. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2008-12-01

    Full Text Available Report of PhD Dissertations. Davide Caffù L'aristocrazia tra corti e città: stili di vita e modelli sociali in alcune fonti narrative dell'Italia nord-occidentale (secoli XII-XIII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo (XIX ciclo, Università degli Studi di Torino, 2007 Lucia Cuttin Le chapitre général des Chartreux et la province de Lombardia propinquior au XVe siècle, Theses de doctorat en Histoire Université de Paris 1 Panthéon-Sorbonne - Università degli Studi di Milano, 2006 Gianmarco De Angelis Poteri cittadini e intellettuali di potere a Bergamo dall'età carolingia all'affermazione del comune. Scrittura, documentazione e iniziativa politica nei secoli IX-XII, Tesi di dottorato di ricerca in Istituzioni, società e religioni dal tardo antico alla fine del medioevo, Università degli Studi di Torino, 2008 Beatrice Del Bo Uomini e strutture di un potere: il marchesato di Monferrato nel XV secolo (1418-1483, Tesi di dottorato in Storia medievale, Università degli Studi di Milano, 2007 Adolfo Morizio Eremitismo e monachesimo in italia tra XIII e XIV secolo: i «Celestini» di fra Pietro del Morrone. Storia e documenti (metà sec. XIII-1320, Tesi di dottorato in Storia del Cristianesimo e delle Chiese, Università degli Studi di Padova, 2008 Eugenio Riversi Intorno alla Vita Mathildis di Donizone. Saggi di contestualizzazione e analisi della rappresentazione, Tesi di dottorato in Storia medievale, Università di Pisa, 2007

  7. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  8. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  9. BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei.

    Directory of Open Access Journals (Sweden)

    Jolene R Bowers

    Full Text Available A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei.

  10. BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei.

    Science.gov (United States)

    Bowers, Jolene R; Engelthaler, David M; Ginther, Jennifer L; Pearson, Talima; Peacock, Sharon J; Tuanyok, Apichai; Wagner, David M; Currie, Bart J; Keim, Paul S

    2010-11-12

    A real-time PCR assay, BurkDiff, was designed to target a unique conserved region in the B. pseudomallei and B. mallei genomes containing a SNP that differentiates the two species. Sensitivity and specificity were assessed by screening BurkDiff across 469 isolates of B. pseudomallei, 49 isolates of B. mallei, and 390 isolates of clinically relevant non-target species. Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei.

  11. Rhetorical distance and knowledge in Burke's blurring of identification and division

    DEFF Research Database (Denmark)

    Kampf, Constance

    of "public knowledge" as discussed by Miller (1982), and the language used for engaging in the action of practicing science as a member of the community "shorthand for situations" from Burke's discussion of entitlement in Language as Symbolic Action.  In the shared situations inherent to participation...... in knowledge creation processes, an element of personal knowledge (Polyani, 1958) on behalf of the participants as individuals can be understood to be present as well, reflected in Burke's notion of "terministic screens," which, in turn, plays a key role in selecting and deflecting ideas as a reductive process....... (2000). SECI, Ba and Leadership: a Unified Model of Dynamic Knowledge Creation. Long Range Planning, Volume 33, Number 1. pp. 5-34(30). Paré, A. and Smart, G. (1994). Observing Genres in Action: Towards a Research Methodology. in eds. Freedman, A. & Medway, P. Genre and the New Rhetoric. Bristol, PA...

  12. Gaussian particle flow implementation of PHD filter

    Science.gov (United States)

    Zhao, Lingling; Wang, Junjie; Li, Yunpeng; Coates, Mark J.

    2016-05-01

    Particle filter and Gaussian mixture implementations of random finite set filters have been proposed to tackle the issue of jointly estimating the number of targets and their states. The Gaussian mixture PHD (GM-PHD) filter has a closed-form expression for the PHD for linear and Gaussian target models, and extensions using the extended Kalman filter or unscented Kalman Filter have been developed to allow the GM-PHD filter to accommodate mildly nonlinear dynamics. Errors resulting from linearization or model mismatch are unavoidable. A particle filter implementation of the PHD filter (PF-PHD) is more suitable for nonlinear and non-Gaussian target models. The particle filter implementations are much more computationally expensive and performance can suffer when the proposal distribution is not a good match to the posterior. In this paper, we propose a novel implementation of the PHD filter named the Gaussian particle flow PHD filter (GPF-PHD). It employs a bank of particle flow filters to approximate the PHD; these play the same role as the Gaussian components in the GM-PHD filter but are better suited to non-linear dynamics and measurement equations. Using the particle flow filter allows the GPF-PHD filter to migrate particles to the dense regions of the posterior, which leads to higher efficiency than the PF-PHD. We explore the performance of the new algorithm through numerical simulations.

  13. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

  14. Beyond the Burke-Fahn-Marsden Dystonia Rating Scale: deep brain stimulation in childhood secondary dystonia.

    Science.gov (United States)

    Gimeno, Hortensia; Tustin, Kylee; Selway, Richard; Lin, Jean-Pierre

    2012-09-01

    Deep brain stimulation is now widely accepted as an effective treatment for children with primary generalized dystonia. More variable results are reported in secondary dystonias and its efficacy in this heterogeneous group has not been fully elucidated. Deep brain stimulation outcomes are typically reported using impairment-focused measures, such as the Burke-Fahn-Marsden Dystonia Rating Scale, which provide little information about function and participation outcomes or changes in non-motor areas. The aim is to demonstrate that in some cases of secondary dystonia, the sole use of impairment level measures, such as the Burke-Fahn-Marsden Dystonia Rating Scale, may be insufficient to fully evaluate outcome following deep brain stimulation. Six paediatric cases who underwent deep brain stimulation surgery with a minimum of one year follow up were selected on the basis of apparent non-response to deep brain stimulation, defined as a clinically insignificant change in the Burke-Fahn-Marsden Dystonia Movement Scale (stimulation, parallel outcome measures demonstrated significant benefit in a range of child and family-centred goal areas including: pain and comfort, school attendance, seating tolerance, access to assistive technology and in some cases carer burden. Sole use of impairment-focused measures, are limited in scope to evaluate outcome following deep brain stimulation, particularly in secondary dystonias. Systematic study of effects across multiple dimensions of disability is needed to determine what deep brain stimulation offers patients in terms of function, participation, care, comfort and quality of life. Deep brain stimulation may offer meaningful change across multiple domains of functioning, disability and health even in the absence of significant change in dystonia rating scales. Copyright © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  15. Improved adsorption energetics within density-functional theory using revised Perdew-Burke-Ernzerhof functionals

    DEFF Research Database (Denmark)

    Hammer, Bjørk; Hansen, Lars Bruno; Nørskov, Jens Kehlet

    1999-01-01

    A simple formulation of a generalized gradient approximation for the exchange and correlation energy of electrons has been proposed by Perdew, Burke, and Ernzerhof (PBE) [Phys. Rev. Lett. 77, 3865 (1996)]. Subsequently Zhang and Yang [Phys. Rev. Lett. 80, 890 (1998)] have shown that a slight...... revision of the PBE functional systematically improves the atomization energies for a large database of small molecules. In the present work, we show that the Zhang and Yang functional (revPBE) also improves the chemisorption energetics of atoms and molecules on transition-metal surfaces. Our test systems...

  16. Educational outcomes for students enrolled in MD-PhD programs at medical school matriculation, 1995-2000: a national cohort study.

    Science.gov (United States)

    Jeffe, Donna B; Andriole, Dorothy A; Wathington, Heather D; Tai, Robert H

    2014-01-01

    To describe educational outcomes for a national cohort of students who enrolled in MD-PhD programs at medical school matriculation (MD-PhD matriculants). The authors used multivariate logistic regression to identify factors independently associated with overall MD-PhD program attrition (MD-only graduation or medical school withdrawal/dismissal) compared with MD-PhD program graduation among the 1995-2000 national cohort of MD-PhD matriculants at medical schools with and without Medical Scientist Training Program (MSTP) support. Of 2,582 MD-PhD matriculants, 1,885 (73.0%) were MD-PhD graduates, 597 (23.1%) were MD-only graduates, and 100 (3.9%) withdrew/were dismissed from medical school by July 2011. MD-PhD matriculants at non-MSTP-funded schools (adjusted odds ratio [AOR], 1.96; 95% confidence interval [CI], 1.60-2.41) and who had lower Medical College Admission Test scores (PhD program; matriculants who reported greater planned career involvement in research (AOR, 0.65; 95% CI, 0.51-0.84) and matriculated more recently (AOR, 0.90; 95% CI, 0.85-0.96) were less likely to leave the MD-PhD program. Gender, race/ethnicity, and premedical debt were not independently associated with overall MD-PhD program attrition. Most MD-PhD matriculants completed the MD-PhD program; most of those who left were MD-only graduates. Findings regarding variables associated with attrition can inform efforts to recruit and support students through successful completion of MD-PhD program requirements.

  17. Edmund Burke and the issue of a conservative and liberal tradition in Italy, 1791-1945 – Call for Reviewers

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2012-11-01

    Full Text Available We are submitting the article Edmund Burke and the issue of a conservative and liberal tradition in Italy, 1791-1945 by Mauro Lenci to an experimental open peer review. Commenting is easy: you should simply register here, log in our Commentbfp site.

  18. A PHD in histone language

    Science.gov (United States)

    Chandrika, Nulu Naga Prafulla; Sundaravelpandian, Kalaipandian; Schmidt, Wolfgang

    2013-01-01

    Post-translational modifications of core histones are important for various DNA-templated processes such as transcription and repair. We recently reported that the ALFIN LIKE 6 (AL6) gene, identified in a forward genetic screen, is critical for phosphate deficiency-induced root hair formation and several other processes associated with the regulation of cellular phosphate homeostasis. AL6 contains a Plant Homeo Domain (PHD) finger that can bind to trimethylated lysine 4 of histone H3 (H3K4me3). Homozygous mutants defective in AL6 expression form very short root hairs under phosphate-deficient conditions, presumably caused by altered expression of putative primary and secondary down-stream targets of AL6. In this Addendum, we speculate about possible roles of AL6, H3K4 trimethylation and other chromatin modifications in the adaptation of plants to low phosphate availability. PMID:23531693

  19. Characteristics of a PHD Finger Subtype.

    Science.gov (United States)

    Boamah, Daniel; Lin, Tao; Poppinga, Franchesca A; Basu, Shraddha; Rahman, Shahariar; Essel, Francisca; Chakravarty, Suvobrata

    2018-01-05

    Although the plant homeodomain (PHD) finger superfamily is known for its site-specific readouts of histone tails, the origins of the mechanistic differences in histone H3 readout by different PHD subtypes remain less clear. We show that sequences containing the xCDxCDx motif in the PHD treble clef (xCDxCDx-PHD) constitute a distinct subtype, based on the following observations: (i) the amino acid composition of the binding site is strikingly different from other subtypes due to position-specific enrichment of negatively charged and bulky nonpolar residues, (ii) the binding site positions are mutually and positively correlated, and this correlation is absent in other subtypes, and (iii) there are only small structural deviations, despite low sequence similarity. The xCDxCDx-PHD constitutes ∼20% of the PHD family, and the double PHD fingers (DPFs) are 10% of the total number of xCDxCDx-PHDs. This subtype originated early in the evolution of eukaryotes but has diversified within the metazoan lineage. Despite sequence diversification, the positions of the enriched nonpolar residues, in particular, show very small structural deviations, suggesting critical contributions of nonpolar residues in the binding mechanism of this subtype. Using mutagenesis, we probed the contributions of the binding-site positions enriched in nonpolar residues in four xCDxCDx-PHD proteins and found that they contribute to the tight packing of the H3 residues. This effect may potentially be exploited, as we observed affinity enhancement upon substituting a bulky nonpolar residue at the same binding site in another histone reader. Overall, we present a detailed characterization of PHD subtypes.

  20. ATLAS PhD Grant Scheme

    CERN Multimedia

    2016-01-01

    In this #CERNandSociety video, the 3 PhD students, awarded the ATLAS PhD Grant in 2015, talk about their research work within the ATLAS Collaboration and how this experience has shaped their future. Find out more about the ATLAS PhD Grant Scheme: cern.ch/ATLASPhDGrant This programme is just one of the many #CERNandSociety projects at CERN. Find out more and how you can be involved: http://cern.ch/go/pBt7

  1. Analisis Fungsi Pakaian Karnaval di Yogyakarta Menurut Roland Barthes dan Fungsi Seni Edmund Burke Felmand

    Directory of Open Access Journals (Sweden)

    Deni Setiawan

    2015-07-01

    Full Text Available Carnival clothing is one form of artists’ creativities in fine art, created in various functions. Those functions are viewed based on utility value and the purpose that consistently are embedded in an art work. In addition, several functions of carnival clothing were constructed on the basis of social and cultural conditions that are effective in a certain place. Each and every type of clothing raises perception to everyone else who sees it. Promotion of fashion style and industry through carnival clothing results in diverse perceptions acceptable to the viewers. Audience’s perceptions are also not apart from the key functions, social ones, and the physical ones of those carnival clothings themselves. Those three functions are the common ones of each art work created as communication tool with everyone else. The carnival clothings are communication tools of the fashion designer to the customers, communication between one customer and another one. On the carnival clothing there are also sources of knowledge science, history, technology, and many other explainable meanings. Through carnival clothings, the detectable issues in physical and non-physical structures are identifiable as well as they play role as the space to make more exploration on the dynamics of a community culture. This article aims to answer the functions of carnival clothing, using aesthetic approach, through the theory of clothing functions Roland Barthes and Edmund Burke Feldman’s art functions. 

  2. A rhetoric of retribution and redemption: Burke's terms for order in the drama of child sexual abuse.

    Science.gov (United States)

    Schultz, Pamela D

    2011-01-01

    Law consists of a series of stories, narratives that embody the values and integrity of a culture. We define crimes, and label the individuals who commit them, along a continuum that moves from the merely unacceptable to the monstrous. One of the most heinous crimes in American society is considered to be child sexual abuse. The sexual abuser of children is firmly established in the public imagination as a modern-day bogeyman, and approaches to prevention and punishment reflect this artificially accelerated panic. Although public policies and correctional measures ostensibly are geared at preventing the crime, they reflect a fundamental misunderstanding as to the motivation of many offenders and the way in which child sexual abuse is perceived as a source of social anomie. This paper uses Kenneth Burke's interpretative framework to examine the social and legal perceptions and treatment of child sexual abusers. First discussed are Burke's conceptions of identity and orientation, which form the basis of human motivation and thus can illuminate the source of offenders' impulses. Next, Burke's "terms for order" are used to show the ways in which the dominant hierarchy compels us to scapegoat and sacrifice in the quest for social redemption. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  4. Assessing nursing student intent for PHD study.

    Science.gov (United States)

    Squires, Allison; Kovner, Christine; Faridaben, Farida; Chyun, Deborah

    2014-11-01

    Nursing faculty shortages threaten a country's ability to produce the amount of nurses necessary to sustain the delivery of healthcare services. Programs that "fast track" graduate education options for registered nurses are one solution to the problem. To (1) evaluate admission criteria into PhD programs for direct entry from a bachelor's degree; (2) ascertain bachelors and masters degree nursing students' perspectives on pursuing a BSN to PhD course of study; (3) clarify factors that influence students' decision-making processes behind pursuing a PhD and identify characteristics of those who would be likely recruits for PhD study; 4) to test the survey questions to develop an instrument for future use. A cross-sectional pilot study. A nursing program at a large urban university in the United States of America with an enrollment of over 1400 students. Currently enrolled bachelor's, master's, and doctor of nursing practice students. Students were sampled via a 10-question (including one open-ended question) electronic mail survey that included 1385 eligible subjects. Among the 606 respondents (57% response rate), 63% were between ages 18 and 30 and 87% indicated that full tuition funding with a living stipend would make them more interested in pursuing a PhD. Current program track was a significant predictor of course of study and area of interest (p=.029). Analysis of the 427 respondents to the open-ended question revealed themes around "time" and "money" as the main barriers to study. The desire to gain clinical experience prior to PhD study was the third theme and an unanticipated finding. The questionnaire offered some predictive ability for gauging intent to study for a PhD among bachelor's and graduate degree prepared nurses. The results do offer some suggestions for nursing workforce development to help address faculty shortages. © 2013.

  5. Caroline E. Akporido Ph.D, Joseohine E. Onohwakpor Ph.D ...

    African Journals Online (AJOL)

    Caroline E. Akporido Ph.D. Josephine E. Onohwakpor Ph.D. Abstract. This paper examines access to environmental information by rural women in some selected oil producing communities in Nigeria. Three oil producing communities constitute the population of this study; they are Ebedei, Uwheru and Bomadi in Delia ...

  6. Interview with Di Gao PhD

    Directory of Open Access Journals (Sweden)

    Di Gao

    2016-04-01

    Full Text Available Di Gao is currently a scientist in the Quality Control department of AstraZeneca. She is responsible for technology transfer, stability programs and supporting regulatory submission. She has a BSc and PhD degree in chemistry and interned with Genentech in 2012. After completing her Ph.D. from University of Michigan in June 2013, she joined the R&D department of the United States Pharmacopeia (USP to support USP monograph modernization and since June 2014 she has been working in her current position at AstraZeneca. Recently, she won a prestigious award from Women in Bio (WIB. WIB is an organization of professionals committed to promoting careers, leadership and entrepreneurship for women in the life sciences. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  7. PhD supervisor-student relationship

    Directory of Open Access Journals (Sweden)

    FILIPE PRAZERES

    2017-10-01

    Full Text Available The relationship between the PhD supervisor and the PhD student is a complex one. When this relationship is neither effective nor efficient, it may yield negative consequences, such as academic failure (1. The intricacy of the supervisor-student relationship may be in part comparable to the one between the physician and his/her patient [see, for example (2]. Both interactions develop over several years and the players involved in each relationship – PhD supervisor-student on the one side and physician-patient on the other side – may at some point of the journey develop different expectations of one another [see, for example (3, 4] and experience emotional distress (5. In both relationships, the perceived satisfaction with the interaction will contribute to the success or failure of the treatment in one case, and in the other, the writing of a thesis. To improve the mentioned satisfaction, not only there is a need to invest time (6, as does the physician to his/ her patients, but also both the supervisor and the PhD student must be willing to negotiate a research path to follow that would be practical and achievable. The communication between the physician and patient is of paramount importance for the provision of health care (7, and so is the communication between the supervisor and PhD student which encourages the progression of both the research and the doctoral study (8. As to a smooth transition to the postgraduate life, supervisors should start thinking about providing the same kind of positive reinforcement that every student is used to experience in the undergraduate course. The recognition for a job well done will mean a lot for a PhD student, as it does for a patient. One good example is the increase in medication compliance by patients with high blood pressure who receive positive reinforcement from their physicians (9. Supervisors can organize regular meetings for (and with PhD students in order to not only discuss their projects

  8. ATLAS PhD Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  9. PhD on Track – designing learning for PhD students

    Directory of Open Access Journals (Sweden)

    Gunhild Austrheim

    2013-12-01

    Full Text Available Three years ago we started the project "Information Management for Knowledge Creation". The project was initiated to create online information literacy modules for PhD students. The result of our endeavours, PhD on Track, will be launched in May 2013. The initial stage of the project was mapping out the information behaviour of PhD students, as well as what services they require from the library through a literature review and a focus group study. The findings of these inquiries formed the knowledge base from which we developed our information literacy modules. Our paper will focus on the interaction between content production and user testing when creating PhD on Track. Methods: User testing has been employed throughout the production stage. We have tested navigation and organisation of the web site, content and usability. The project team have conducted expert testing. Analysis: The results from our user testing have played an important part in decisions concerning content production. Our working hypothesis was that the PhD students would want an encyclopaedic website, a place to quickly find answers. However, the user tests revealed that PhD students understood and expected the website to be learning modules. Conclusions: The PhD students in the tests agreed that a site such as this would be useful, especially to new PhD students. They also liked the design, but had some qualms with the level of information. They preferred shorter text, but with more depth. The students would likewise have preferred more practical examples, more illustrations and more discipline specific information. The current content of PhD on Track reflects the feedback from the user testing. We have retained initial ideas such as one section for reviewing and discovering research literature and one section for publishing PhD research work. In addition, we have included more practical examples to indicate efficient workflows or relevant actions in context. Illustrations

  10. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review.

    Science.gov (United States)

    Wang, Ting; Guo, Rixin; Zhou, Guohong; Zhou, Xidan; Kou, Zhenzhen; Sui, Feng; Li, Chun; Tang, Liying; Wang, Zhuju

    2016-07-21

    Panax notoginseng (Burk.) F.H. Chen is a widely used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is distributed primarily in the southwest of China, has wide-ranging pharmacological effects and can be used to treat cardiovascular diseases, pain, inflammation and trauma as well as internal and external bleeding due to injury. This paper provides up-to-date information on investigations of this plant, including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. The possible uses and perspectives for future investigation of this plant are also discussed. The relevant information on Panax notoginseng (Burk.) F.H. Chen was collected from numerous resources, including classic books about Chinese herbal medicine, and scientific databases, including Pubmed, SciFinder, ACS, Ebsco, Elsevier, Taylor, Wiley and CNKI. More than 200 chemical compounds have been isolated from Panax notoginseng (Burk.) F.H. Chen, including saponins, flavonoids and cyclopeptides. The plant has pharmacological effects on the cardiovascular system, immune system as well as anti-inflammatory, anti-atherosclerotic, haemostatic and anti-tumour activities, etc. Panax notoginseng is a valuable traditional Chinese medical herb with multiple pharmacological effects. This review summarizes the botany, ethnopharmacology, phytochemistry, pharmacology and toxicology of P. notoginseng, and presents the constituents and their corresponding chemical structures found in P. notoginseng comprehensively for the first time. Future research into its phytochemistry of bio-active components should be performed by using bioactivity-guided isolation strategies. Further work on elucidation of the structure-function relationship among saponins, understanding of multi-target network pharmacology of P. notoginseng, as well as developing its new clinical usage and comprehensive utilize will enhance the therapeutic potentials of P. notoginseng. Copyright © 2016

  11. University of Texas M.D. Anderson Cancer Center

    Science.gov (United States)

    ... Videoconferencing Alumni Alumni Alumni Home Giving to the Education Fund Activities About MD Anderson About MD Anderson Home Facts & History Facts & History Facts & History Home Shared Governance Committee ...

  12. Collaborative PhD projects : Together towards innovation

    NARCIS (Netherlands)

    Sjoer, E.

    2015-01-01

    This paper presents the design criteria of collaborative PhD projects for DIMI and DEI, using the existing literature. Collaborative PhD projects will become an interesting learning process for all parties involved.

  13. PhD Students' Work Conditions and Study Environment in University- and Industry-Based PhD Programmes

    Science.gov (United States)

    Kolmos, A.; Kofoed, L. B.; Du, X. Y.

    2008-01-01

    During the last 10 years, new models of funding and training PhD students have been established in Denmark in order to integrate industry into the entire PhD education. Several programmes have been conducted where it is possible to co-finance PhD scholarships or to become an employee as an industrial PhD in a company. An important question is what…

  14. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  15. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  16. PhD competences of food studies

    Directory of Open Access Journals (Sweden)

    Chelo Gonzalez-Martinez

    2014-10-01

    Full Text Available In European Higher Education, learning outcomes and competences have been used sometimes with different meanings and sometimes with the same meaning. But both terms have been more commonly used to refer to knowledge, understanding and abilities a student must demonstrate at the end of a learning experience.  Their use is a consequence of the paradigm shift of the Bologna Process to a learner centered education environment. The definition of standards of competences (or learning outcomes for the PhD degree is thus a need for the quality assurance of this degree. In this work, subject-specific and generic competences for the PhD in Food Science and Technology and their alignment with the European Qualifications Framework (EQF level descriptors for quality assurance purposes have been identified.

  17. Methods of Academic Course Planning for Cancer Biology PhD Students to Enhance Knowledge of Clinical Oncology.

    Science.gov (United States)

    Mattes, Malcolm D; Swart, Elizabeth; Markwell, Steven M; Wen, Sijin; Vona-Davis, Linda C

    2017-09-15

    Little is known about how clinical oncology concepts are taught to PhD students or the most effective methods of doing so. In this study, electronic surveys were sent to faculty and students at PhD training programs, assessing their institution's methods of clinical oncology education and their perspective on optimal approaches to clinical oncology education. Only 40.0% of students reported any clinical oncology component to their institution's training, and only 26.5% had a clinician on their graduate advisory committee. Forty-three percent of students believed that they had a good understanding for translating basic science research into clinical practice, and 77.2% of all participants believed dual degree MD/PhD students were superior to PhD students in this regard. Lectures on clinical oncology research topics were the most valuable type of experience for all participants and were also the most common type of experience utilized. Working with a clinician to develop a clinical trial with correlative endpoints was also highly valued, but was only utilized by approximately 10% of programs. Faculty rated the value of nearly all types of clinical oncology exposure significantly lower than did students. Inclusion of the approaches identified in this study is likely to enhance PhD training in oncology-related disciplines. Cancer Res; 77(18); 4741-4. ©2017 AACR. ©2017 American Association for Cancer Research.

  18. MD2190: Q" Stabilization during injection

    CERN Document Server

    Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2018-01-01

    This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

  19. Correspondence Dated April 17, 1848, from Charles T. Jackson, MD, to John Snow, MD.

    Science.gov (United States)

    Haridas, Rajesh P; Bause, George S

    2017-07-01

    A previously unpublished four-page letter from Charles T. Jackson, MD, to John Snow, MD, was acquired in December 2016 by the Wood Library-Museum of Anesthesiology, Schaumburg, IL. The letter may be a draft or a copy of the letter which may have been sent to Snow in 1848. Jackson's letter to Snow does not reveal any significant new insight into the controversy over the discovery of etherization. A hitherto unknown meeting of Jackson's former chemistry student, Joseph Peabody, and John Snow, MD, was revealed in the letter. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Music and Mind: In Memoriam Professor Carlo Alberto Pagni, MD, PhD: February 13, 1931 -March 1, 2009.

    Science.gov (United States)

    von Wild, Klaus R H

    2017-01-01

    Carlo Alberto Pagni, born in La Spezia, Italy, on February 13, 1931, was an eminent and respected professor of neurosurgery and chairman of the neurosurgical clinic of the University of Turin from 1980 to 2003. He died on March 1, 2009. As a professor of neurology and neurological surgery he was renowned as an expert on vascular, tumor, and functional neurosurgery. Beyond the Italian Neurosurgical Society, he was the doyen of functional neurosurgery, specializing in motor cortex stimulation for the treatment of focal dystonia, Parkinson's disease, and postictal spasticity and pain. His home was his castle, and his family was fundamental to his life. He shared with his wife, Sandra, his passion for piano playing and for their remarkable library, and together with friends, he and his wife enjoyed dinners with fine food and Barolo wines. Listening to this Grand Seigneur talking about and explaining the music of, above all, Ludwig van Beethoven, and Richard Wagner, one felt he was emotionally just "music and mind". You can imagine this from his books on music, chess, and neuroscience. Indeed, he adored playing correspondence chess worldwide. A sportsman too, he loved hiking, mountaineering, skiing, swimming, and fishing. Nature was his source for slowing down, for regenerating, and for collecting his strength for new projects and new challenges. Friends will remember Dr. Pagni as a Grand Seigneur.

  1. CDC's 60th anniversary: director's perspective--David Satcher, M.D., Ph.D., 1993-1998.

    Science.gov (United States)

    2007-06-15

    One of the important legacies at CDC is continuity of leadership. Like runners in a relay race, each CDC leader passes the baton of leadership smoothly to the next without disrupting the important programs necessary to protect the health of the nation. This perspective provides reflections on three aspects of CDC during the mid-1990s: first, continuing momentum in several important programs; second, strengthening CDC's infrastructure in terms of resources, programs, and organization; and third, responding to the emerging epidemic of overweight and obesity and the need to encourage healthy lifestyle choices.

  2. Peter Burke, Hibridismo Cultural, Ediciones Akal, Madrid, 2010 (Trad. Sandra Chaparro Martínez) 158 p.

    OpenAIRE

    Brower Beltramin, Jorge

    2012-01-01

    Peter Burke, uno de los historiadores de la cultura más notables de las últimas décadas,  nos entrega en este texto,  un ensayo teórico iluminador y sugerente en torno a uno de los fenómenos frecuentemente analizados en estos tiempos de globalización: el hibridismo cultural. Antes de referirnos a la arquitectura conceptual de este magnífico ensayo teórico es necesario hacer una referencia al estudio preliminar realizado por la profesora María José  del Río Barredo para la edición en español d...

  3. Response to commentary by Skinner et al. on Regression to the Mean (RTM) in Burke et al.

    Science.gov (United States)

    Burke, Rachel M; Kay, Christi; Gazmararian, Julie

    2015-05-07

    This letter is a response to commentary by Skinner et al. on an evaluation by Burke et al. of the HealthMPowers program, an elementary-school-based program developed to improve child health and wellness. In their commentary, Skinner et al. make the criticism that our results for changes in BMI-for-Age Z score were simply reflective of Regression to the Mean (RTM). In this response, we show that while some of our results are consistent with RTM, with adjustment we do still observe some small effects in BMI-for-Age Z score over the course of the school year. We conclude that while our evaluation was not definitive, we still believe that programs of similar design to HealthMPowers merit further rigorous study.

  4. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

    Science.gov (United States)

    Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

    2017-07-11

    Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

  5. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  6. The MD and MS degrees in Britain.

    OpenAIRE

    McManus, I. C.

    1988-01-01

    Higher medical degrees--MD and MS--have been awarded at an increased rate since 1980, owing partly to increased numbers of medical graduates and partly to greater career competition. The pass rate has not changed since 1965. Regulations at various universities show substantial differences, particularly in the use of viva voce examinations for failed candidates, in permissible subject matter, and in allowing the submission of previously published papers. As these degrees are important for care...

  7. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output....... The situation has thus created a paradox. On the one hand, it has become essential for institutions to have many PhD students and for the research performed to be of the highest level. On the other hand, the careers of PhD students are not necessarily going to be directly related to the research performed...

  8. Understanding Non-Traditional PhD Students Habitus--Implications for PhD Programmes

    Science.gov (United States)

    Naidoo, Devika

    2015-01-01

    Against the background of vast changes in doctoral education and the emergence of non-traditional doctoral programmes, this paper investigates the habitus of non-traditional PhD students at a South African university. Bourdieu's conceptual tool of habitus informed the study. In-depth and open-ended interviews were conducted with 10 non-traditional…

  9. Rethinking the PhD in geography: overview and introduction

    OpenAIRE

    Boyle, Mark

    2015-01-01

    Today many Higher Education Institutions (HEIs) are actively upscaling, refining and improving their existing PhD programs. Geography PhD programs have not been immune from these developments. The intention of this Special Issue (SI) is to further build and fortify the community of interest which is now forming around the changing trajectory of the PhD degree in Geography by: (a) providing a brief resume of knowledge and thinking about the principal problems which c...

  10. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter the... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

  11. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would...

  12. Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016)

    OpenAIRE

    Carretero Pérez, Jesús; García Blas, Javier; Petcu, Dana

    2016-01-01

    Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016) Timisoara, Romania. February 8-11, 2016. The PhD Symposium was a very good opportunity for the young researchers to share information and knowledge, to present their current research, and to discuss topics with other students in order to look for synergies and common research topics. The idea was very successful and the assessment made by the PhD Student was very good. It also helped t...

  13. Molecular Cloning of phd1 and Comparative Analysis of phd1, 2, and 3 Expression in Xenopus laevis

    Directory of Open Access Journals (Sweden)

    Dandan Han

    2012-01-01

    Full Text Available Intensive gene targeting studies in mice have revealed that prolyl hydroxylase domain proteins (PHDs play important roles in murine embryonic development; however, the expression patterns and function of these genes during embryogenesis of other vertebrates remain largely unknown. Here we report the molecular cloning of phd1 and systematic analysis of phd1, phd2, and phd3 expression in embryos as well as adult tissues of Xenopus laevis. All three phds are maternally provided during Xenopus early development. The spatial expression patterns of phds genes in Xenopus embryos appear to define a distinct synexpression group. Frog phd2 and phd3 showed complementary expression in adult tissues with phd2 transcription levels being high in the eye, brain, and intestine, but low in the liver, pancreas, and kidney. On the contrary, expression levels of phd3 are high in the liver, pancreas, and kidney, but low in the eye, brain, and intestine. All three phds are highly expressed in testes, ovary, gall bladder, and spleen. Among three phds, phd3 showed strongest expression in heart.

  14. Gordon Fullerton in PCA (MD-11) Simulator

    Science.gov (United States)

    1998-01-01

    NASA research pilot Gordon Fullerton 'flying' in the MD-11 simulator during the Propulsion Controlled Aircraft (PCA) project. This investigation grew out of the crash of a DC-10 airliner on July 19, 1989, following an explosion in the rear engine which caused the loss of all manual flight controls. The flight crew attempted to control the airliner using only the thrust from the two remaining engines. Although the DC-10 crashed during the landing attempt, 184 of the 296 passengers and crew aboard survived. The PCA effort at the Dryden Flight Research Center grew out of the crash, and attempted to develop a means to successfully land an aircraft using only engine thrust. After more than five years of work, on August 29, 1995, Gordon Fullerton made the first PCA touchdown aboard an MD-11 airliner (a later version of the DC-10). The concept was further refined over the years that followed this first landing. Simulators were essential ingredients of the PCA development process. The feasibility of the concept was first tested with an F-15 simulator, then the results of actual flight tests in an F-15 were incorporated back into the simulator. Additional simulations were run on the Boeing 720 airliner simulator used in the Controlled Impact Demonstration project. After the MD-11 test landings, Boeing 747 and 757 simulators tested a wide range of possible situations. Simulations even helped develop a method of landing an airliner if it lost its complete hydraulic system as well as a wing engine, by transferring fuel to shift the center of gravity toward the working engine. The most extreme procedure was undertaken in a 747 simulator. The aircraft simulated the loss of the hydraulic system at 35,000 feet and rolled upside down. Then, the PCA mode was engaged, the airliner righted itself, leveled its wings, and made an approach nearly identical to that of a normal auto landing.

  15. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  16. LHC MD 2042: Persistent Injection Oscillations

    CERN Document Server

    Karpov, Ivan; Argyropoulos, Theodoros; Baudrenghien, Philippe; Chapochnikova, Elena; Timko, Helga; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the measurements performed to study persistent longitudinal oscillations after injection into the LHC. It was found that they build up due to mismatch, and can lead to particle losses and uncontrolled bunch lengthening. For the first time, profile measurements and ObsBox data acquisitions were triggered at injection to obtain first-turn data. The measurements took place on 16th September 2017 between 14:30 and 19:30, and between 27th November 2017 20:00 and 28th November 2017 04:00.

  17. The MD and MS degrees in Britain.

    Science.gov (United States)

    McManus, I C

    1988-07-09

    Higher medical degrees--MD and MS--have been awarded at an increased rate since 1980, owing partly to increased numbers of medical graduates and partly to greater career competition. The pass rate has not changed since 1965. Regulations at various universities show substantial differences, particularly in the use of viva voce examinations for failed candidates, in permissible subject matter, and in allowing the submission of previously published papers. As these degrees are important for careers, and are registrable by the General Medical Council, it is suggested that it should issue minimal standards to be observed by all universities.

  18. 33 CFR 334.180 - Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md.

    Science.gov (United States)

    2010-07-01

    ... areas, U.S. Naval Air Test Center, Patuxent River, Md. 334.180 Section 334.180 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.180 Patuxent River, Md.; restricted areas, U.S. Naval Air Test Center, Patuxent River, Md...

  19. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  20. Rethinking PhD Learning Incorporating Communities of Practice

    Science.gov (United States)

    Shacham, Miri; Od-Cohen, Yehudit

    2009-01-01

    This paper grows from research which focuses on the learning characteristics of PhD students, incorporating communities of practice both during their studies and beyond completion of their PhD, and drawing on theories of adult learning and lifelong learning. It shows how professional discourse enhances academic discourse through student engagement…

  1. A Renaissance in Engineering PhD Education

    Science.gov (United States)

    Akay, Adnan

    2008-01-01

    This paper addresses the role of engineering PhD education and its relationship to innovation and technology, and the need to reconsider how we educate PhD engineers. Much of the effort on engineering education in the last two decades focused on undergraduate education with a few exceptions that relate to master degree programs. Doctoral education…

  2. Exploring the intricacies of contemporary Phd research process ...

    African Journals Online (AJOL)

    The process leading to a PhD degree award has evolved over a period of many years to become what it is today. There are important considerations and emphasis continually being placed by the degree awarding authorities on the PhD research process leading to this award. The authors of this communication wish to ...

  3. [Stop the compulsive PhD trajectory for junior doctors].

    Science.gov (United States)

    Clevers, J C Hans

    2014-01-01

    It has become the rule rather than the exception that junior doctors in training spend 3-4 years on a research project, culminating in a thesis. Without a PhD, clinical career prospects within and outside academia look rather bleak. Here I argue that PhD degrees should be pursued only by the most talented and motivated young clinicians.

  4. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  5. Ante Šiljeg, PhD in Interdisciplinary Sciences

    Directory of Open Access Journals (Sweden)

    Sanja Lozić

    2013-12-01

    Full Text Available Ante Šiljeg defended his doctoral thesis The Digital Relief Model in Analysis of Geomorphometric Parameters – Example of PP Vrana Lake at Faculty of Science, University of Zagreb on June 20th, 2013 (supervisor Sanja Lozić, PhD, assistant professor and received a PhD degree in the field of interdisciplinary science, field of geography, branch of applied geography. Doctoral thesis was defended in front of committee composed of Mladen Pahernik, PhD, assistant professor, Danijel Orešić, PhD, associate professor and Aleksandar Toskić, PhD, associate professor. Commitee for disertation review was in the same composition.

  6. Necessary organizational changes according to Burke-Litwin model in the head nurses system of management in healthcare and social welfare institutions - the Slovenia experience.

    Science.gov (United States)

    Filej, Bojana; Skela-Savic, Brigita; Vicic, Visnja H; Hudorovic, Narcis

    2009-05-01

    To discover which changes should be implemented in the system of head nursing management in Slovenian healthcare institutions and social welfare institutions. The questionnaire was distributed to 155 head nurses of Slovenian hospitals, primary healthcare centres and social welfare institutions. The Burke-Litwin organizational change model has been used to look at which changes have to be implemented in the management system of head nurses. In hospitals head nurses have greater independent competence for planning professional training of nursing employees (psocial welfare institutions, and "system (policies and procedures)" for primary healthcare centres. According to results of our study, changes are needed in leadership and management of nursing in primary healthcare centres. In social welfare institutions changes are only required in leadership. Organizational changes are not necessary for any element of the Burke-Litwin model for hospitals.

  7. Occurrence of Hysterothylacium and Anisakis nematodes (Ascaridida: Ascaridoidea) in the tanaka's snailfish Liparis tanakae (Gilbert & Burke) (Scorpaeniformes: Liparidae).

    Science.gov (United States)

    Guo, Yan-Ning; Xu, Zhen; Zhang, Lu-Ping; Hu, Yong-Hong; Li, Liang

    2014-04-01

    The tanaka's snailfish Liparis tanakae (Gilbert & Burke) (Scorpaeniformes: Liparidae) is an economically important marine fish species in China. However, the helminth parasites of this fish are still poorly known. During a helminthological survey of Chinese marine fishes from 2011 to 2012, we revealed that L. tanakae was heavily infected with third-stage larvae and adults of ascaridoid nematodes (total prevalence 100% and mean intensity 82.3 nematodes per fish). Four species of third-stage larvae Hysterothylacium liparis Li, Xu & Zhang, 2007, H. aduncum (Rudolphi, 1802), Hysterothylacium fabri (Rudolphi, 1819), and Anisakis pegreffii (Campana-Rouget & Biocca, 1955) and a single species of adults H. liparis were differentiated and identified by morphological and molecular methods. The detailed morphology of the four species of third-stage larvae was also studied using light microscopy and scanning electron microscopy. The morphological and molecular characterization of the third-stage larvae of H. liparis was reported. Liparis tanakae represents a new host record for A. pegreffii and H. fabri. In addition, a new name, Hysterothylacium zhoushanense nom. nov. was also given to Hysterothylacium zhoushanensis Li, Liu & Zhang, 2012 to make the latinized specific epithet agree with this neuter generic name.

  8. Contenido de los nutrientes básicos en Catolaccus grandis Burks criados sobre larvas del picudo del algodon

    Directory of Open Access Journals (Sweden)

    ARAUJO LÚCIA HELENA AVELINO

    2000-01-01

    Full Text Available El objetivo del trabajo fue determinar los niveles de carbohidratos, proteínas solubles y aminoácidos libres de larvas, pupas hembras y adultos hembras de Catolaccus grandis (Burks (Hymenoptera: Pteromalidae criados sobre larvas del picudo del algodón envenenadas por hembras del parasitoide y por larvas de primer instar del parasitoide. Esto estudio fue conducido en la Unidade de Investigación de Control Biologico de Plagas del Departamento de Agricultura de los Estados Unidos de la América, en Weslaco, Texas. Las 20 muestras de cada uno de los tres estados de desarrollo: tercer instar larval, pupas hembra y adultos hembra del parasitoide C. grandis, fueron separadas y pesadas individualmente y se cuantió el contenido de carbohidratos totales, proteínas solubles totales y aminoácidos libres criados en diferentes sustratos. Los resultados obtenidos confirman la existencia de patrones metabólicos significativamente distintos de estos nutrientes básicos.

  9. Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

    Science.gov (United States)

    Yang, Chunzhang; Zhuang, Zhengping; Fliedner, Stephanie M J; Shankavaram, Uma; Sun, Michael G; Bullova, Petra; Zhu, Roland; Elkahloun, Abdel G; Kourlas, Peter J; Merino, Maria; Kebebew, Electron; Pacak, Karel

    2015-01-01

    We have investigated genetic/pathogenetic factors associated with a new clinical entity in patients presenting with pheochromocytoma/paraganglioma (PHEO/PGL) and polycythemia. Two patients without hypoxia-inducible factor 2α (HIF2A) mutations, who presented with similar clinical manifestations, were analyzed for other gene mutations, including prolyl hydroxylase (PHD) mutations. We have found for the first time a germ-line mutation in PHD1 in one patient and a novel germ-line PHD2 mutation in a second patient. Both mutants exhibited reduced protein stability with substantial quantitative protein loss and thus compromised catalytic activities. Due to the unique association of patients' polycythemia with borderline or mildly elevated erythropoietin (EPO) levels, we also performed an in vitro sensitivity assay of erythroid progenitors to EPO and for EPO receptor (EPOR) expression. The results show inappropriate hypersensitivity of erythroid progenitors to EPO in these patients, indicating increased EPOR expression/activity. In addition, the present study indicates that HIF dysregulation due to PHD mutations plays an important role in the pathogenesis of these tumors and associated polycythemia. The PHD1 mutation appears to be a new member contributing to the genetic landscape of this novel clinical entity. Our results support the existence of a specific PHD1- and PHD2-associated PHEO/PGL-polycythemia disorder. • A novel germ-l i n e PHD1 mutation causing heochromocytoma/paraganglioma and polycythemia. • Increased EPOR activity and inappropriate hypersensitivity of erythroid progenitors to EPO.

  10. 76 FR 2607 - Airworthiness Directives; MD Helicopters, Inc. (MDHI) Model MD900 Helicopters

    Science.gov (United States)

    2011-01-14

    ... MDHI Model MD900 helicopters. That AD currently requires turning on both Vertical Stabilizer Control... Stability Augmentation System (YSAS) for the Model 500N and 600N helicopters and to the VSCS for the Model... also requires turning ON both VSCS switches to reduce pilot workload and to help control the helicopter...

  11. Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

    Science.gov (United States)

    Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

    2018-02-14

    Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students.

  13. Medical paternalism in House M.D.

    Science.gov (United States)

    Wicclair, M R

    2008-12-01

    The popular television series House M.D. is drawn upon to provide a critical examination of medical paternalism and how it is presented in the show. Dr Gregory House, the character named in the title of the series, is a paradigm of a paternalistic physician. He believes that he knows what is best for his patients, and he repeatedly disregards their wishes in order to diagnose and treat their illnesses. This paper examines several examples of medical paternalism and the means used to portray it favourably in the series. It is argued that the positive depiction of medical paternalism in the fictional world of the series does not apply in the real world. The paper also considers why a show that features a paternalistic physician who so blatantly flouts mainstream medical ethics might appeal to health professionals and members of the general public.

  14. Beam-Based Collimator Alignment MD

    CERN Document Server

    Assmann, R; Muller, GJ; Redaelli, S; Salvachua, B; Valentino, G

    2012-01-01

    The MD was performed on 21st April 2012, and was split into two parts. First, the alignment of a horizontal IR3 collimator was performed at different Dp/p cuts of the IR3 TCP to observe any improvements in the BLM spike quality. Secondly, new additions to the beam-based collimator alignment software aimed at speeding up the alignment were tested. The new features include coarse alignment of the collimator jaws around the BPM-interpolated orbit and new sequences in the parallel alignment algorithm to ensure that both jaws touch the beam before fine sequential alignment can proceed. The new software allowed 27 collimators to be aligned in 1 hour 45 minutes, which translates to a total of 5.5 hours for all collimators, an improvement of 2 hours over the previous best time achieved in the March 2012 setups.

  15. Innovation in Learning: PhD and DNP Student Collaborations.

    Science.gov (United States)

    Eaton, Linda H; Gordon, Debra B; Doorenbos, Ardith Z

    2017-09-01

    Working together, PhD and Doctor of Nursing Practice (DNP) students can advance knowledge creation and the translation of knowledge into practice. Although different in purpose and education, PhD and DNP programs should prepare students to collaborate throughout their careers. This article describes an innovative pilot project that partnered PhD and DNP students during their graduate programs. Group meetings were used to facilitate collaboration among 12 PhD and DNP students interested in pain management. Using a five-stage collaboration process model, students worked together on dissertation and capstone projects. PhD and DNP students collaborated on the completion of dissertation and capstone projects, as well as on publications and presentations. A case example of an effective partnership is included. Partnering of PhD and DNP students can further the development of new nursing knowledge and evidence-based practice. Successful collaboration can be facilitated by PhD and DNP faculty. [J Nurs Educ. 2017;56(9):556-559.]. Copyright 2017, SLACK Incorporated.

  16. MD1228: Validation of Single Bunch Stability Threshold & MD1751: Instability Studies with a Single Beam

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Buffat, Xavier; Iadarola, Giovanni; Lasocha, Kacper; Li, Kevin Shing Bruce; Levens, Tom; Metral, Elias; Salvant, Benoit; Tambasco, Claudia; CERN. Geneva. ATS Department

    2017-01-01

    Instabilities were being routinely observed in B1V during ADJUST. The timing of the instabilities has been localised to shortly after the TOTEM bump has been implemented. The result is emittance blowup which can negatively effect the luminosity output of the fill. This MD aimed to rule out possible sources of the instability (i.e. beam-beam effects or electron cloud) by only taking one single beam to 6.5TeV and going through the full machine cycle. After the implementation of the TOTEM bump, a reduction of the octupole current was performed in order to determine if there was a discrepancy in the threshold between simulations and measurement. As a precursor, the results of the End of Fill MD: Validation of Single Bunch Stability Threshold will also be described.

  17. Meet EPA Scientist Dermont Bouchard, Ph.D.

    Science.gov (United States)

    EPA Scientist Dermont Bouchard, Ph.D., is working to better understand how tiny nanomaterials might be released into the environment. His research helps regulators and other decision-makers lower risks and better protect human health and the environment

  18. Meet EPA Chemist Linda Sheldon, Ph.D.

    Science.gov (United States)

    Environmental chemist Linda Sheldon, Ph.D, is the Associate Director for Human Heath in the National Exposure Research Laboratory. She studies environmental exposure, particularly focusing on children's environments and their contact with chemicals.

  19. Meet EPA Scientist Tim Shafer, Ph.D.

    Science.gov (United States)

    Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

  20. Meet EPA Chemist Quincy Teng, Ph.D.

    Science.gov (United States)

    EPA research chemist Quincy Teng, Ph.D., focuses on the application of metabolomics—a relatively new, specialized field of biochemistry focused on studying small molecules known as metabolites—on environmental and life sciences.

  1. Meet EPA Ecologist Paul Mayer, Ph.D.

    Science.gov (United States)

    EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

  2. Meet EPA Engineer Shawn Ryan, Ph.D.

    Science.gov (United States)

    Shawn Ryan, Ph.D. is a chemical engineer at EPA's National Homeland Security Research Center. He has worked at EPA for 12 years, nine of which have been devoted to leading research to support decontamination and consequence management.

  3. Meet EPA Scientist Jeff Szabo, Ph.D.

    Science.gov (United States)

    EPA scientist Jeff Szabo, Ph.D., has worked for the EPA’s National Homeland Security Research Center since 2005. He conducts and manages water security research projects at EPA’s Test and Evaluation facility.

  4. Meet EPA Scientist Heriberto Cabezas, Ph.D.

    Science.gov (United States)

    Heriberto Cabezas, Ph.D. is currently the Senior Science Advisor to the Sustainable Technology Division in EPA's National Risk Management Research Lab, where he works to advance the application of science and technologies to address sustainability.

  5. Meet EPA Scientist Jordan West, Ph.D.

    Science.gov (United States)

    Jordan West, Ph.D. is an aquatic ecologist at EPA. Her areas of expertise include freshwater & marine ecology, climate change impacts and adaptation, resilience and threshold theory, environmental risk assessment, expert elicitation & stakeholder processes

  6. Meet EPA Scientist Michael Nye, Ph.D.

    Science.gov (United States)

    Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

  7. Meet EPA Scientist Valerie Zartarian, Ph.D.

    Science.gov (United States)

    Senior exposure scientist and research environmental engineer Valerie Zartarian, Ph.D. helps build computer models and other tools that advance our understanding of how people interact with chemicals.

  8. Meet EPA Scientist Susan Yee, Ph.D.

    Science.gov (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  9. Meet EPA Scientist Blake Schaeffer, Ph.D.

    Science.gov (United States)

    EPA research ecologist Blake Schaeffer, Ph.D. focuses on ways to use satellite remote sensing technology to monitor water quality. His research interests broadly include deriving water quality parameters in coasts, estuaries, and lakes using satellites

  10. Meet EPA Scientist Jody Shoemaker, Ph.D.

    Science.gov (United States)

    EPA research chemist Jody Shoemaker, Ph.D., works to support Agency efforts to protect drinking water. She helps develop methods for analyzing organic chemicals on the Drinking Water Contaminant Candidate List (CCL).

  11. Meet EPA Environmental Engineer Terra Haxton, Ph.D.

    Science.gov (United States)

    EPA Environmental Engineer Terra Haxton, Ph.D., uses computer simulation models to protect drinking water. She investigates approaches to help water utilities be better prepared to respond to contamination incidents in their distribution systems.

  12. Meet EPA Natural Resource Economist Marisa Mazzotta, Ph.D.

    Science.gov (United States)

    Marisa Mazzotta, Ph.D. currently works as an Economist at EPA's Atlantic Ecology Division. Her research focuses on the public's valuation and prioritization of natural resources, and the relationship between ecological changes and economic benefits.

  13. Brenda K. Edwards, PhD | DCCPS/NCI/NIH

    Science.gov (United States)

    Brenda K. Edwards, PhD, has been with the Surveillance Research Program (SRP) and its predecessor organizations at the National Cancer Institute (NCI) since 1989, serving as SRP’s Associate Director from 1990-2011.

  14. Structural insight into histone recognition by the ING PHD fingers.

    Science.gov (United States)

    Champagne, Karen S; Kutateladze, Tatiana G

    2009-05-01

    The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of DNA damage repair, cellular senescence and apoptosis. All members of the ING family contain unique amino-terminal regions and a carboxy-terminal plant homeodomain (PHD) finger. While the amino-terminal domains associate with a number of protein effectors including distinct components of histone deacetylase (HDAC) and histone acetyltransferase (HAT) complexes, the PHD finger binds strongly and specifically to histone H3 trimethylated at lysine 4 (H3K4me3). In this review we describe the molecular mechanism of H3K4me3 recognition by the ING1-5 PHD fingers, analyze the determinants of the histone specificity and compare the biological activities and structures within subsets of PHD fingers. The atomic-resolution structures of the ING PHD fingers in complex with a H3K4me3 peptide reveal that the histone tail is bound in a large and deep binding site encompassing nearly one-third of the protein surface. An extensive network of intermolecular hydrogen bonds, hydrophobic and cation-pi contacts, and complementary surface interactions coordinate the first six residues of the H3K4me3 peptide. The trimethylated Lys4 occupies an elongated groove, formed by the highly conserved aromatic and hydrophobic residues of the PHD finger, whereas the adjacent groove accommodates Arg2. The two grooves are connected by a narrow channel, the small size of which defines the PHD finger's specificity, excluding interactions with other modified histone peptides. Binding of the ING PHD fingers to H3K4me3 plays a critical role in regulating chromatin acetylation. The ING proteins function as tethering molecules that physically link the HDAC and HAT enzymatic complexes to chromatin. In this review we also highlight progress recently made in understanding the molecular basis underlying biological and tumorigenic activities of the ING tumor suppressors.

  15. Orbit Feedback Operation with RCBX (MD 1209)

    CERN Document Server

    Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

    2017-01-01

    The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

  16. LHC MD 1279: Bunch Flattening in Physics

    CERN Document Server

    AUTHOR|(CDS)2073675; Baudrenghien, Philippe; Esteban Muller, Juan; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    Vertex reconstruction is not accurate enough for LHCb when the bunch length in physics shrinks below about 0.9 ns. The end-of-fill MD studies presented here proved that bunch flattening using sinusoidal RF modulation is a loss-free method to increase the r.m.s. bunch length and flatten the bunch profile. Furthermore, the optimum modulation parameters to be used in physics have been identified. Subsequently, bunch flattening in physics was used operationally with a modulation frequency of 98.75 % of the central synchrotron frequency and 0.6 modulation amplitude, resulting in a 150-200 ps increase in the BQM-measured bunch length. A ‘mid-of-fill’ test at arrival to flat top revealed that also the bunch distribution created by the controlled emittance blow-up during the ramp is affected when bunch flattening is applied. The measurements took place on 17th June and the 4th, 7th and 22nd July 2016. Operational cases are shown as well.

  17. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  18. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  19. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

    2012-01-01

    textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

  20. The experience of disagreement between students and supervisors in PhD education: a qualitative study

    OpenAIRE

    Gunnarsson, Ronny; Jonasson, Grethe; Billhult, Annika

    2013-01-01

    Background PhD supervision is mostly individual and disagreement between supervisors and PhD students is a seldom-discussed topic at universities. The present study aimed to describe the experience of disagreement between PhD students and supervisors. Methods Nine supervisors and seven PhD students from Sweden and England were interviewed using a video recorder. The recorded material was analysed using inductive content analysis. Results Disagreements in PhD education can be described with th...

  1. PhD students: making research and publishing

    Directory of Open Access Journals (Sweden)

    Ioan Sporea, MD, PhD

    2016-12-01

    Full Text Available PhD student time is very interesting in the life of researchers. Many of them are young graduates, without or with very few experience in the field of scientific research. During four years, they must become experts in a narrow field (virtually, the subject of their PhD thesis, but at the same time they have to be trained for research and for publishing. Is it possible? It is mandatory! PhD students start with a one year training in the basic field of research during which they attend different courses regarding how to search the literature, how to perform research, how to perform statistical analysis, how to prepare a paper, where and how to publish and so on. Following this training year, together with their mentor (the coordinator of the PhD thesis, the PhD student starts working on the thesis. And this means reading as much as possible significant published data regarding his/her subject, proper research (basic, experimental, or clinical, and finally preparing papers for publication (in the beginning as abstracts for different meetings and later as original articles in dedicated journals.Participation of PhD students to different meetings is important to improve the quality of their research as an exercise for oral presentations. On the other hand, oral presentation is useful because the paper is open for discussion and corrections can be made during and after the oral presentation. During last ten years, there were organized conferences for PhD students and young doctors, particularly in Târgu Mureș and Timișoara. It was a good opportunity to show results, to discuss and to cooperate.This is why in December 2016, the Doctoral School of Victor Babes University of Medicine and Pharmacy decided to organize a scientific competition between PhD students, in an interesting scientific session. The top 10 PhD students (according to the cumulative Impact Factor of their first author publications were invited to present their scientific research

  2. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations.Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003Segnalazione di tesi di dottorato. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV

  3. Tesi di dottorato PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2001-12-01

    Full Text Available

    Segnalazione di tesi di dottorato.

     

    Antonella Ambrosio

    Oratrices nostrae. Un'esperienza monastica nella Napoli di fine Medioevo, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001

     

    Cristina Andenna

    Mortariensis Ecclesia. Una congregazione canonicale nel secolo XII, Tesi di dottorato di ricerca in Storia medioevale, Università Cattolica del Sacro Cuore di Milano, 2001

     

    Elena Bellomo

    La milizia del Tempio in Italia nord-occidentale (XII-metà XIV secolo, Tesi di dottorato di ricerca in Storia medioevale, Università Cattolica del Sacro Cuore di Milano, 2001

     

    Barbara Bombi

    Innocenzo III e la "praedicatio" ai pagani del Nord Europa. Missione e crociata in Livonia (1198-1216, Tesi di dottorato di ricerca in Storia medioevale, Università Cattolica del Sacro Cuore di Milano, 2001

     

    Rita Di Fiore

    La Regia Curia dal 1282 al 1392. Organigramma politico e quadri di potere, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001

    Report of PhD Dissertations.

     

    Antonella Ambrosio

    Oratrices nostrae. Un'esperienza monastica nella Napoli di fine Medioevo, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Palermo, 2001

     

    Cristina Andenna

    Mortariensis Ecclesia. Una congregazione canonicale nel secolo XII, Tesi di dottorato di ricerca in Storia medioevale, Università Cattolica del Sacro Cuore di Milano, 2001

     

    Elena Bellomo

    La milizia del Tempio in Italia nord-occidentale (XII-metà XIV secolo, Tesi di dottorato di ricerca in Storia medioevale, Università Cattolica del

  4. The National Institute of Nursing Research Graduate Partnerships Program (NINR-GPP): an opportunity for PhD students.

    Science.gov (United States)

    Engler, Mary B; Austin, Joan K; Grady, Patricia

    2014-01-01

    The Institutional Graduate Partnerships Program (GPP) offered by the National Institute of Nursing Research (NINR) provides an exceptional opportunity for students who are enrolled in any PhD program in nursing across the nation to complete dissertation research on the premier research campus of the National Institutes of Health, Bethesda, MD. The goal of this doctoral fellowship program, which is up to 3 years in length, is to train promising doctoral students in basic and clinical research. This knowledge and skill set is necessary for the next generation of nurse scientists to ultimately conduct translational research. In this article, the authors describe the program, eligibility requirements, application procedures, and selection criteria for NINR-supported GPP nursing students. Also provided are tips for interested students and outcomes of current and former NINR-supported GPP students (NINR-GPP). Published by Elsevier Inc.

  5. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  6. The Training and Work of Ph.D. Physical Scientists

    Science.gov (United States)

    Smith, S. J.; Schweitzer, A. E.

    2003-05-01

    Doctoral education has often been viewed as the pinnacle of the formal education system. How useful is doctoral training in one's later career? In an NSF-funded project, we set out to perform a study of the training, careers, and work activities of Ph.D. physical scientists. The study included both in-depth interviews and a survey sent out to a sample of Ph.D. holders 4-8 years after graduation. Come and find out the results of this study: What skills are most Ph.D. physical scientists using? What should graduate programs be teaching? Are Ph.D.'s who are working in their specific field of training happier than their counterparts working different jobs? What skills and preparation lead to future job satisfaction, perhaps the most important indicator of the "success" of graduate education? A preprint and further details can be found at the project web site at: spot.colorado.edu/ phdcarer.

  7. An analysis of Ph.D. examiners' reports in engineering

    Science.gov (United States)

    Prieto, Elena; Holbrook, Allyson; Bourke, Sid

    2016-03-01

    In recent years, there have been increasing calls for an overall transformation of the nature of engineering Ph.D. programs and the way theses are assessed. There exists a need to understand the examination process to ensure the best quality outcome for candidates in engineering. The work we present in this paper uses data collected between 2003 and 2010 for a total of 1220 Australian Ph.D. theses by analysing examiner reports. Our analysis indicates that Ph.D. theses in engineering, N = 106, differ considerably from those in other fields in areas such as gender of candidates and examiners and the examiners' geographical location. We also found that assessment areas such as significance and contribution of the thesis, publications arising from the thesis, breadth, depth and recency of the literature review and communication and editorial correctness are areas in which the proportion of text of engineering examiners' comments differs significantly from other fields.

  8. Italian PhD students abroad: Exploring the mobility of PhD students in urban studies

    Directory of Open Access Journals (Sweden)

    Marilena Prisco

    2015-12-01

    Full Text Available Global changings in higher education as well as the internationalisation of European education and research institutes have occurred during the last decades deeply affecting the Italian PhD system. The mobility of PhD students has become an important issue to take into account both for its impact on the evolution of the Italian academia and for the job market. The study presented here aims to have an insight into the consequences of the internationalisation process. It is based on a two-step data collection (a data enquiry and a survey on PhD students of urban studies who were hosted by non-Italian universities during their doctoral course between 2002 and September 2015. According to data, PhD students of urban studies could represent a great potential for the internationalisation process of the Italian academia even though both doctoral students and institutions do not seem to be completely aware of this and to fully invest on it yet. Furthermore, the gathered data has shown that experience at a foreign university proves valuable for PhD candidates, who state they had thus improved or acquired considerable skills and opportunities. The study revealed also that part of PhDs who participated in the survey is currently in the research field, both in academia or in the public or private research sector.

  9. Harvard College Observatory: Shapley's Factory for PhD Degrees?

    Science.gov (United States)

    Welther, B. L.

    2000-12-01

    When Harlow Shapley assumed the Directorship of Harvard College Observatory in 1921, there was no program in place there to train the next generation of astronomers. In 1923, using the Pickering Fund for women assistants, Shapley hired a young English woman, Cecilia Payne, to work on stellar spectra. Just two short years later, Payne completed her research and wrote a celebrated thesis on stellar atmospheres. Because Harvard University was not prepared to confer a PhD degree on a woman at that time, Payne presented her thesis to Radcliffe College. Thus, in 1925 she became the first person to receive a PhD in astronomy for a research project at HCO. By 1933, a PhD in Astronomy had been conferred on eight graduate students who had undertaken research projects at HCO: four men who received their degree from Harvard, and four women, from Radcliffe. In subsequent years, however, the equal distribution of degrees for men and women quickly changed. When the 30th degree was bestowed in 1943, only 10 of the candidates were women. By 1955, when the 60th degree was conferred, only 14 women had received a PhD. In just two decades, then, the ratio of women astronomers had steadily dropped from a solid 50% at the height of the Shapley era to slightly less than 25% at his retirement. Also, until the mid-1960s, the women astronomers still had to apply to Radcliffe for their PhD degrees. This paper will briefly examine the funding and research topics of some of the HCO PhD candidates in the Shapley Era (1921-1955). It will also highlight some of their subsequent contributions to 20th-century American Astronomy.

  10. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    Directory of Open Access Journals (Sweden)

    Martie Gillen

    2016-12-01

    Full Text Available Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counseling and Planning, and Financial Planning Review. Asebedo currently serves as President-Elect for the Financial Therapy Association. She earned her Ph.D. in Personal Financial Planning from Kansas State University.

  11. Hydrogeology and water quality of the Dublin and Midville aquifer systems at Waynesboro, Burke County, Georgia, 2011

    Science.gov (United States)

    Gonthier, Gerard

    2013-01-01

    The hydrogeology and water quality of the Dublin and Midville aquifer systems were characterized in the City of Waynesboro area in Burke County, Georgia, based on geophysical and drillers’ logs, flowmeter surveys, a 24-houraquifer test, and the collection and chemical analysis of water samples in a newly constructed well. At the test site, the Dublin aquifer system consists of interlayered sands and clays between depths of 396 and 691 feet, and the Midville aquifer system consists of a sandy clay layer overlying a sand and gravel layer between depths of 728 and 936 feet. The new well was constructed with three screened intervals in the Dublin aquifer system and four screened intervals in the Midville aquifer system. Wellbore-flowmeter testing at a pumping rate of 1,000 gallons per minute indicated that 52.2 percent of the total flow was from the shallower Dublin aquifer system with the remaining 47.8 percent from the deeper Midville aquifer system. The lower part of the lower Midville aquifer (900 to 930 feet deep), contributed only 0.1 percent of the total flow. Hydraulic properties of the two aquifer systems were estimated using data from two wellbore-flowmeter surveys and a 24-hour aquifer test. Estimated values of transmissivity for the Dublin and Midville aquifer systems were 2,000 and 1,000 feet squared per day, respectively. The upper and lower Dublin aquifers have a combined thickness of about 150 feet and the horizontal hydraulic conductivity of the Dublin aquifer system averages 10 feet per day. The upper Midville aquifer, lower Midville confining unit, and lower Midville aquifer have a combined thickness of about 210 feet, and the horizontal hydraulic conductivity of the Midville aquifer system averages 6 feet per day. Storage coefficient of the Dublin aquifer system, computed using the Theis method on water-level data from one observation well, was estimated to be 0.0003. With a thickness of about 150 feet, the specific storage of the Dublin aquifer

  12. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available

    Report of PhD Dissertations.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

    Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.

     

    Marco Bicchierai

    Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004

     

    Emanuela Garimberti

    Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004

     

    Lorenzo Tanzini

    Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Stefania Tarquini

    Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

    Segnalazione di tesi di dottorato.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

  13. Survey on the Labour Market Position of PhD Graduates: Competence comparison and relation between PhD and current employment

    Energy Technology Data Exchange (ETDEWEB)

    Heuritsch, J.; Waaijer, C.J.F.; Van der Weijden, I.C.M.

    2016-07-01

    We compared the skills PhD graduates acquired during their PhDs to the ones they need in their current job. We also studied the relation between PhD topic and content of the current job of recent PhD graduates. Data was collected in a survey of 1,133 respondents with a PhD from five Dutch universities between early 2008 and mid-2012. We show that scientific skills and independence are developed sufficiently during the PhD education, whereas PhDs are lacking in management and communication skills. These competence discrepancies were compared to the educational level required for the PhD holder’s current job and the relatedness of the current job to the PhD topic. (Author)

  14. beta* leveling with telescopic ATS squeeze (MD 2410)

    CERN Document Server

    Wenninger, Jorg; Hostettler, Michi; Pojer, Mirko; Ponce, Laurette; Tydecks, Tobias; CERN. Geneva. ATS Department

    2017-01-01

    Luminosity leveling by beta* is the baseline operational scenario of HL-LHC, and this leveling technique may be used in 2018 or during run~3 depending on the beam parameters and beta* range. During this MD beta*leveling was commissioned successfully for the first time with the telescopic squeeze over the beta* range of 40 cm to 30 cm. A novel beta* leveling controls technique based on a modification of the LSA trim was also tested during the MD.

  15. Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

    Science.gov (United States)

    Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

    2017-01-01

    MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple (Malus×domestica). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1, and MdPR10-2. In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26. In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

  16. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  17. Enhancing the skills of PhD supervisors facing internationalization

    DEFF Research Database (Denmark)

    Bøgelund, Pia

    2013-01-01

    interview study within the faculty, and an inquiry into the field of cross-cultural supervision with the purpose of enhancing the skills of PhD supervisors. As is often the case with cross-cultural exchange and inquiry, the study ended up by being just as informative on the supervision cultures and settings...

  18. Troubling Talk: Assembling the PhD Candidate

    Science.gov (United States)

    Mewburn, I.

    2011-01-01

    When PhD students complain it is assumed there are problems and that troubles talk is evidence of a "sick" research candidature or culture. This paper argues that such a one-dimensional reading fails to attend closely to the academic identity work that is done when students talk together. Identity work has become a useful way of thinking about the…

  19. PhD thesis: Multipartite entanglement and quantum algorithms

    OpenAIRE

    Alsina, Daniel

    2017-01-01

    PhD thesis dealing with various aspects of multipartite entanglement, such as entanglement measures, absolutely maximally entangled states, bell inequalities, entanglement spectrum and quantum frustration. Also some quantum algorithms run with the IBM quantum computer are covered, together with others applied to adiabatic quantum computation and quantum thermodynamics.

  20. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    This technical report contains the proceedings of the Ph.D. Workshop held in conjunction with the The 24th IFIP Int. Conference on Testing Software and Systems (ICTSS'12) in Aalborg, Denmark, November 19, 2012. The well‐established ICTSS series of international conferences addresses the conceptua...

  1. PhD thesis: The relationship between expertise and creativity

    DEFF Research Database (Denmark)

    Boysen, Mikkel Snorre Wilms

    2015-01-01

    I Ph.d. projektet undersøges sammenhænge mellem ekspertise og kreativitet via et eksperiment, hvor eksperter og novicer laver musik ved computer. Musikken vurderes efterfølgende af en række fokusgrupper. Studiet peger overraskende på, at novicer på linje med eksperter er i stand til at skabe musi...

  2. PhD Students, Interculturality, Reflexivity, Community and Internationalisation

    Science.gov (United States)

    Holliday, Adrian

    2017-01-01

    Interviews with a small group of doctoral students at a British university indicate that the students feel that the programme provides an environment within which they develop interculturality through reflexive engagement with the PhD community and in some cases with the participants in their research. Significant here is that they are…

  3. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  4. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  5. MD Family Medicine - Calicut experience: History is made here

    Directory of Open Access Journals (Sweden)

    M Roshni

    2016-01-01

    Full Text Available Government Medical College, Calicut, Kerala - the first medical college in India to start Doctor of Medicine (MD in family medicine as a postgraduate course. This was in the year 2012. Till date, this is the only medical college to have MD Family Medicine program in India. The college was allowed two MD Family Medicine seats per year by the Medical Council of India, and this is a 3 year course. The first batch of MD Family Medicine students has passed out from the Government Medical College, Calicut in July 2015. In this article, the author, who has been working as an assistant professor in the Department of Family Medicine, ever since the department started in the year 2012, shares her experiences in setting up the department, its functioning and the achievement of bringing out the first batch of successful MD Family Medicine specialists. Another laurel, of which the institution is proud of, is that they were able to incorporate family medicine teaching program in the MBBS curriculum. A brief introduction about Government Medical College, Calicut, is also given.

  6. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  7. Undertaking Individual Transdisciplinary PhD Research for Sustainable Development: Case Studies from South Africa

    Science.gov (United States)

    van Breda, John; Musango, Josephine; Brent, Alan

    2016-01-01

    Purpose: This paper aims to improve the understanding of individual transdisciplinary PhD research in a developing country context, focusing on three individual PhD case studies in South Africa. Design/Methodology/Approach: Multiple-case method was used, and three completed transdisciplinary PhD research efforts undertaken at the Stellenbosch…

  8. 3MdB: the Mexican Million Models database

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  9. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  10. Restructuring the syllabus for MD Pharmacology: Retrospection of bioassay

    Directory of Open Access Journals (Sweden)

    Sarita Mulkalwar

    2014-01-01

    Full Text Available Introduction: Career prospects in Pharmacology are witnessing a sea change due to fast and unanticipated development in the field of clinical research. Numerous openings exist now in academia, pharmaceutical industry, Clinical Research Organizations (CRO or as regulatory consultants, experimental pharmacologists, etc. In short, there are various options to choose from, depending on one′s interest. It′s high time we ponder now over the training programme for post-graduate students in Pharmacology. It needs to be revised keeping in mind the job prospects & uniqueness of the MD Pharmacology degree. Aim: To take suggestions of experienced pharmacologists on the present syllabus for MD Pharmacology and their opinion on continuation of Bioassay experiment which is currently an important part of it . Materials and Methods: A structured questionnaire was given to 30 experienced pharmacologists to seek their opinion on MD Pharmacology syllabus & continuation of Bioassay as a part of MD practical. Results: Out of 30 participants, 29 (96.6% did not use their knowledge of Bioassay during their 10 years of post MD career, whether in pharmaceutical industry or in academics. Only 5 of them (16.6% feel that experiment on bioassay should be continued in the current state. 76.7% of them wish it to be modified to a Dose Response Curve ( DRC . 6.71% feel that it should be totally scrapped. All the participants feel the need of revising current MD Pharmacology syllabus. Current syllabus is inclined more towards preparing good academicians but it lacks the proper training for creating good clinical research professionals. Medical writing, writing necessary documents for clinical trials including regulatory documents, writing an article for medical journals, marketing communication, product monograph and patient information of a clinical trial could be incorporated. They should be aware of the regulatory requirements for conducting studies on investigational drugs

  11. MD 2179: Scraping of off-momentum halo after injection

    CERN Document Server

    Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

    2018-01-01

    In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

  12. Club of Bologna International Best PhD Prize 2012

    Directory of Open Access Journals (Sweden)

    Marco Fiala

    2012-06-01

    Full Text Available The Club of Bologna, in collaboration with UNACOMA, will be awarding a prize for the best PhD theses on subjects related to agricultural machinery design and development. Up to ten theses will be selected and the best five of these will have the chance of being presented during the annual Club of Bologna meeting that will be held from 9 to 10 November 2012, on occasion of the EIMA. The authors of the best three PhD theses will also receive a cash prize. The winners will be guests in Bologna of UNACOMA who will cover travelling expenses and hotel accommodation for 2 nights. They will also meet farm machinery manufacturers attending the international trade fair. The winners of the Club of Bologna Prize 2012 will be announced here. Application forms and further information can be downloaded from the Club of Bologna website (http://www.clubofbologna.org/.

  13. Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

    Science.gov (United States)

    Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

    2015-10-01

    Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  14. Iranian PhD student wins human-rights prize

    Science.gov (United States)

    Cartwright, Jon

    2013-11-01

    A physicist imprisoned in Iran while on a break from his PhD studies in the US has been awarded a human-rights prize. Omid Kokabee, who had been based at the University of Texas in Austin, has been given the Andrei Sakharov Prize from the American Physical Society (APS) for "his courage in refusing to use his physics knowledge to work on projects that he deemed harmful to humanity, in the face of extreme physical and psychological pressure".

  15. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    OpenAIRE

    Martie Gillen

    2016-01-01

    Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counselin...

  16. The Voice of PhD Candidates and PhD Supervisors. A Qualitative Exploratory Study amongst PhD Candidates and Supervisors to Evaluate the Relational Aspects of PhD Supervision in the Netherlands

    Directory of Open Access Journals (Sweden)

    Marla Woolderink

    2015-07-01

    The study shows that a good match between PhDs and supervisors is essential for a successful PhD trajectory, and we advise that both discuss and formally agree upon mutual expectations and responsibilities within the project. We advocate that Graduate Schools foster an open and safe learning environment, organise meetings where supervisors can share experiences to learn from one another, provide contacts for advice and support and involvement of HR during the selection process.

  17. Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

    Science.gov (United States)

    Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

    2016-12-01

    Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  18. Edward Jenner, MD, and the scourge that was.

    Science.gov (United States)

    White, P J; Shackelford, P G

    1983-09-01

    This article was inspired by the global eradication of smallpox in 1980. Rather than reiterate the recent history of this remarkable achievement, we have chosen to celebrate the event by reviewing the early history of smallpox immunization and the contribution of Edward Jenner, MD, to this endeavor. In addition, we present these historical events within the context of knowledge acquired by modern virologists.

  19. Physical Properties of Near-Earth Asteroid 2011 MD

    NARCIS (Netherlands)

    Mommert, M.; Farnocchia, D.; Hora, J. L.; Chesley, S. R.; Trilling, D. E.; Chodas, P. W.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.

    2014-01-01

    We report on observations of near-Earth asteroid 2011 MD with the Spitzer Space Telescope. We have spent 19.9 h of observing time with channel 2 (4.5 {\\mu}m) of the Infrared Array Camera and detected the target within the 2{\\sigma} positional uncertainty ellipse. Using an asteroid thermophysical

  20. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans...

  1. Thomas Secker M.D.: Archbishop and man-midwife.

    Science.gov (United States)

    Morgan-Guy, John

    2018-01-01

    This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

  2. MD SIMULATION OF SUBTILISIN BPN' IN A CRYSTAL ENVIRONMENT

    NARCIS (Netherlands)

    HEINER, AP; BERENDSEN, HJC; VANGUNSTEREN, WF

    1992-01-01

    In this paper we present a molecular dynamics (MD) simulation of subtilisin BPN' in a crystalline environment containing four protein molecules and solvent. Conformational and dynamic properties of the molecules are compared with each other and with respect to the X-ray structure to test the

  3. The Added Value of a PhD in Medicine--PhD Students' Perceptions of Acquired Competences

    Science.gov (United States)

    Anttila, Henrika; Lindblom-Ylänne, Sari; Lonka, Kristi; Pyhältö, Kirsi

    2015-01-01

    PhD in the field of medicine is more common than in any other domain. Many medical doctors are driven towards PhD, but also students with other backgrounds (usually MSc) are conducting a PhD in medical schools. Higher education has invested a lot in developing generic and research competences. Still little is known about how PhD students…

  4. [The tribute of the pioneer of hypnotherapy--Franz Anton Mesmer, MD, PhD in the history of psychotherapy and medicine].

    Science.gov (United States)

    Radovancević, Ljubomir

    2009-01-01

    Modern hypnosis started with the Austrian physician Franz Anton Mesmer (1734-1815), who believed that the phenomenon known as mesmerism, or animal magnetism, or fluidum was related to an invisible substance--a fluid that runs within the subject or between the subject and the therapist, that is, the hypnotist, or the "magnetizer". The term hypnosis was introduced in the 1840s by a Scottish surgeon James Braid (1795-1860), who believed the subject to be in a particular state of sleep--a trance. In the late 19th century, a French neurologist Jean Martin Charcot (1825-1893) thought hypnotism to be a special physiological state, and his contemporary Hyppotite-Marie Bernheim (1840-1919) believed it to be a psychological state of heightened suggestibility. Sigmund Freud, who studied with Charcot, used hypnosis early in his career to help patients recover repressed memories. He noted that patients would relive traumatic events while under hypnosis, a process know as abreaction. Freud later replaced hypnosis with the technique of free associations. Today, hypnosis is used as a form of therapy (hypnotherapy), a method of investigation to recover lost memories, and research tool. According to Caplan & Sadock, F.A. Mesmer is generally thought of as the fons et origo of modern psychotherapy; and from the early techniques of mesmerism, it is said, have evolved the more elaborate and sophisticated therapeutic measures of the analyst and his colleagues. Although Mesmer was certainly dealing with individuals suffering from a variety of neurotic disorders, and though the clinical successes he achieved were the result of psychological processes that his procedures induced in his patients, Mesmer's theoretical formulations, his understanding of the nature of the treatment he developed, and his specific procedures were all totally different from those of the 20th century analyst. He was one of the corne stones in the development of psychoanalysis through hypnosis mainly of hysterical patients.

  5. Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory.

  6. Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D

    Directory of Open Access Journals (Sweden)

    Wolpert Lewis

    2010-08-01

    Full Text Available Abstract Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.

  7. The balneologist Professor Julius Glax, MD, PhD (1846–1922 and his activities in Rogaška Slatina

    Directory of Open Access Journals (Sweden)

    Janez Fischinger

    2013-11-01

    Full Text Available Rogaška Slatina health resort was promoted by many doctors, but their names have been almost or completely forgotten by now. One of those doctors was also Professor Dr. Julius Glax. He worked in Rogaška Slatina as a health resort physician and during this time he published numerous articles on the therapeutic effects of Rogaška Slatina mineral water. He emphasized that mineral water treatment proved to have a healing effect in various diseases. He also wrote about different types of Rogaška Slatina mineral springs and represented Rogaška Slatina as an important medical health resort. He also held lectures on these topics in Graz Medical Association and in Austrian Academy of Sciences in Vienna.

  8. MdCOP1 ubiquitin E3 ligases interact with MdMYB1 to regulate light-induced anthocyanin biosynthesis and red fruit coloration in apple.

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-10-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species.

  9. MS PHD'S Professional Development Program: A Scientific Renaissance in Cyberspace

    Science.gov (United States)

    Powell, J. M.; Williamson, V. A.; Griess, C. A.; Pyrtle, A. J.

    2004-12-01

    This study is a component of a four-year investigation of MS PHD'S Professional Development Program's virtual community through the lenses of underrepresented minority students in Earth system science and engineering fields. In this presentation, the development, assessment and projected utilization of the ongoing study will be discussed. The overall goal of this study is to examine the effectiveness of virtual team building methods and understand how the development of a communal cyberinfrastructure acts as an integral part of the emergence of a Scientific Renaissance. The exemplar, Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S), provides professional development experiences to facilitate the advancement of students of color achieving outstanding Earth system careers. Undergraduate and graduate students are supported through access to scientific conferences, mentorship and virtual community building. Framed by critical theory, this ethnographic exploration uses a mixed methods research design to record, observe, and analyze both the processes and products of the website, listserv and synchronous web-based dialogue. First, key findings of the formative evaluation and annual reports of the successfully implemented 2003 MS PHD'S Pilot Project are presented. These findings inform future evaluations of the use of technological resources and illustrate how this public space provides peer support and enriched research opportunities. Quantitative methods such as statistical analysis, academic and professional tracking and evaluative tools for scientific content and competency are complimented by qualitative methods that include observations, heuristic case studies and focus group interviews. The findings of this ongoing investigation will provide insight on how national organizations, higher education practitioners, community-based support systems and underrepresented minorities in the sciences promote diversity by developing

  10. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  11. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  12. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  13. MD 1856 - Landau Damping: Beam Transfer Functions and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Boccardi, Andrea; Buffat, Xavier; Gasior, Marek; Lefevre, Thibaut; Levens, Tom; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Pieloni, Tatiana; Crouch, Matthew Paul; CERN. Geneva. ATS Department

    2017-01-01

    In the 2012, 2015 and 2016 several instabilities were developing during the betatron squeeze where beam-beam interactions become stronger modifying the tune spread provided by the octupoles magnets. Studies of the stability area computed by evaluating the dispersion integral for different tune spread couldn’t explain the 2012 observed instabilities during the squeeze. The size of the stability area given by the computed dispersion integral depends on the transverse tune spread but its shape is defined by the particle distribution in the beams. Therefore any change of the particle distribution due to for instance a diffusion from excited resonances can lead to a deterioration of the Landau stability area. The Beam Transfer Functions (BTF) measurements are direct measurement of the Stability Diagrams (SD). They are sensitive to the particle distribution and contain information about the transverse tune spread in the beams. In this MD we wanted to verify the findings of MD 1407 and try to explain observed inst...

  14. MD 1691: Active halo control using tune ripple at injection

    CERN Document Server

    Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

    2017-01-01

    In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

  15. Summary of LHC MD:377: Schottky pick-up

    CERN Document Server

    Betz, Michael; Lefevre, Thibaut; CERN. Geneva. ATS Department

    2015-01-01

    The main objective of this MD was to record Schottky spectra under well known machine conditions. In summary, 7 set-points for the chromaticity and 8 for the emittance have been established and Schottky spectra have been recorded for each setting. The data will be used to benchmark and develop different fitting algorithms. This note presents the initial attempt of curve-fitting and discusses its shortcomings.

  16. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  17. Space charge studies in the PSB - MD report

    CERN Document Server

    Forte, V; Martini, M; Schmidt, F; Yu Molodozhentsev, A

    2014-01-01

    In the framework of the LHC Injectors Upgrade (LIU) project [1], this document summarizes the PSB Machine Development (MD) studies in 2012-2013, before the Long Shutdown 1 (LS1), focused on space charge eects analysis at the future 160 MeV injection energy from the Linac4. Different phenomena have been analysed to understand the behaviour of the machine and permit benchmarks with simulation codes.

  18. Anzibert A. Rugakingira, MD student, Tumaini University – KCM ...

    African Journals Online (AJOL)

    0655711075

    Anzibert A. Rugakingira, MD student, Tumaini University – KCM-. COLLEGE. DMSJ 2012; 19: 22-27 http://dx.doi.org/10.4314/dmsj.v19i1.5. 1.0 Abstract ..... den of disease, it spends less than 1% of the total global health expenditure. In this regard, innovative healthcare delivery and financing models will be needed to ensure ...

  19. Burke-Fahn-Marsden dystonia severity, Gross Motor, Manual Ability, and Communication Function Classification scales in childhood hyperkinetic movement disorders including cerebral palsy: a 'Rosetta Stone' study.

    Science.gov (United States)

    Elze, Markus C; Gimeno, Hortensia; Tustin, Kylee; Baker, Lesley; Lumsden, Daniel E; Hutton, Jane L; Lin, Jean-Pierre S-M

    2016-02-01

    Hyperkinetic movement disorders (HMDs) can be assessed using impairment-based scales or functional classifications. The Burke-Fahn-Marsden Dystonia Rating Scale-movement (BFM-M) evaluates dystonia impairment, but may not reflect functional ability. The Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), and Communication Function Classification System (CFCS) are widely used in the literature on cerebral palsy to classify functional ability, but not in childhood movement disorders. We explore the concordance of these three functional scales in a large sample of paediatric HMDs and the impact of dystonia severity on these scales. Children with HMDs (n=161; median age 10y 3mo, range 2y 6mo-21y) were assessed using the BFM-M, GMFCS, MACS, and CFCS from 2007 to 2013. This cross-sectional study contrasts the information provided by these scales. All four scales were strongly associated (all Spearman's rank correlation coefficient rs >0.72, pdisorders including cerebral palsy can be effectively evaluated using these scales. © 2015 Mac Keith Press.

  20. Cross-scale MD simulations of dynamic strength of tantalum

    Science.gov (United States)

    Bulatov, Vasily

    2017-06-01

    Dislocations are ubiquitous in metals where their motion presents the dominant and often the only mode of plastic response to straining. Over the last 25 years computational prediction of plastic response in metals has relied on Discrete Dislocation Dynamics (DDD) as the most fundamental method to account for collective dynamics of moving dislocations. Here we present first direct atomistic MD simulations of dislocation-mediated plasticity that are sufficiently large and long to compute plasticity response of single crystal tantalum while tracing the underlying dynamics of dislocations in all atomistic details. Where feasible, direct MD simulations sidestep DDD altogether thus reducing uncertainties of strength predictions to those of the interatomic potential. In the specific context of shock-induced material dynamics, the same MD models predict when, under what conditions and how dislocations interact and compete with other fundamental mechanisms of dynamic response, e.g. twinning, phase-transformations, fracture. In collaboration with: Luis Zepeda-Ruiz, Lawrence Livermore National Laboratory; Alexander Stukowski, Technische Universitat Darmstadt; Tomas Oppelstrup, Lawrence Livermore National Laboratory. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  1. MD2036: UFO Dynamics Studies and UFO Fast Detection

    CERN Document Server

    Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

    2017-01-01

    UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

  2. Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

    Directory of Open Access Journals (Sweden)

    Cheolhoon Kim

    2017-11-01

    Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

  3. AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.

    Science.gov (United States)

    Gaetani, Massimiliano; Matafora, Vittoria; Saare, Mario; Spiliotopoulos, Dimitrios; Mollica, Luca; Quilici, Giacomo; Chignola, Francesca; Mannella, Valeria; Zucchelli, Chiara; Peterson, Pärt; Bachi, Angela; Musco, Giovanna

    2012-12-01

    Mutations in autoimmune regulator (AIRE) gene cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of peripheral-tissue antigens to mediate deletional tolerance, thereby preventing self-reactivity. AIRE contains two plant homeodomains (PHDs) which are sites of pathological mutations. AIRE-PHD fingers are important for AIRE transcriptional activity and presumably play a crucial role in the formation of multimeric protein complexes at chromatin level which ultimately control immunological tolerance. As a step forward the understanding of AIRE-PHD fingers in normal and pathological conditions, we investigated their structure and used a proteomic SILAC approach to assess the impact of patient mutations targeting AIRE-PHD fingers. Importantly, both AIRE-PHD fingers are structurally independent and mutually non-interacting domains. In contrast to D297A and V301M on AIRE-PHD1, the C446G mutation on AIRE-PHD2 destroys the structural fold, thus causing aberrant AIRE localization and reduction of AIRE target genes activation. Moreover, mutations targeting AIRE-PHD1 affect the formation of a multimeric protein complex at chromatin level. Overall our results reveal the importance of AIRE-PHD domains in the interaction with chromatin-associated nuclear partners and gene regulation confirming the role of PHD fingers as versatile protein interaction hubs for multiple binding events.

  4. The experience of disagreement between students and supervisors in PhD education: a qualitative study.

    Science.gov (United States)

    Gunnarsson, Ronny; Jonasson, Grethe; Billhult, Annika

    2013-09-28

    PhD supervision is mostly individual and disagreement between supervisors and PhD students is a seldom-discussed topic at universities. The present study aimed to describe the experience of disagreement between PhD students and supervisors. Nine supervisors and seven PhD students from Sweden and England were interviewed using a video recorder. The recorded material was analysed using inductive content analysis. Disagreements in PhD education can be described with the overarching theme: the nature of the disagreements changes over time. Five categories emerged to describe the variations of the experiences: involvement in important decisions, supervisors not being up-to-date, dubious advice from supervisors, mediating between supervisors, and interpersonal relationships. There is a gradual shift in competence where PhD students may excel supervisors in subject knowledge. Early disagreements may indicate immaturity of the student while disagreements later may indicate that the student is maturing making their own decisions. Consequently, disagreements may need to be addressed differently depending on when they occur. Addressing them inappropriately might slow the progressions and result in higher attrition rate among PhD students. The five categories may be elements in future PhD supervisor training programs and should be further evaluated for their importance and impact on PhD education.

  5. Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells

    NARCIS (Netherlands)

    Wolfs, Tim G. A. M.; Dunn-Siegrist, Irène; van't Veer, Cornelis; Hodin, Caroline M. I. M.; Germeraad, Wilfred T. V.; van Zoelen, Marieke A. D.; van Suylen, Robert-Jan; Peutz-Kootstra, Carine J.; Elson, Greg; Pugin, Jérôme; Buurman, Wim A.

    2008-01-01

    MD-2 is the crucial cofactor of TLR4 in the detection of LPS. Here, we show that soluble MD-2 (sMD-2) circulates in plasma of healthy individuals as a polymeric protein. The total amount of sMD-2 in septic plasma was strongly elevated and contained both sMD-2 polymers and monomers, the latter

  6. An Apple Protein Kinase MdSnRK1.1 Interacts with MdCAIP1 to Regulate ABA Sensitivity.

    Science.gov (United States)

    Liu, Xiao-Juan; Liu, Xin; An, Xiu-Hong; Han, Peng-Liang; You, Chun-Xiang; Hao, Yu-Jin

    2017-10-01

    ABA is a crucial phytohormone for development and stress responses in plants. Snf1-related protein kinase 1.1 (SnRK1.1) is involved in the ABA response. However, the molecular mechanism underlying the SnRK1.1 response to ABA is largely unknown. Here, it was found that overexpression of the apple MdSnRK1.1 gene enhanced ABA sensitivity in both transgenic apple calli and Arabidopsis seedlings. Subsequently, a yeast two-hybrid screen demonstrated that MdCAIP1 (C2-domain ABA Insensitive Protein1) interacted with MdSnRK1.1. Their interaction was further confirmed by pull-down and co-immunoprecipitation assays. Expression of the MdCAIP1 gene was positively induced by ABA. Its overexpression enhanced ABA sensitivity in transgenic apple calli. Furthermore, it was found that MdSnRK1.1 phosphorylated the MdCAIP1 protein in vivo and promoted its degradation in vitro and in vivo. As a result, MdSnRK1.1 inhibited MdCAIP1-mediated ABA sensitivity, and MdCAIP1 partially reduced MdSnRK1.1-mediated ABA sensitivity. Our findings indicate that MdSnRK1.1 plays an important role in the ABA response, partially by controlling the stability of the MdCAIP1 protein. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  7. Validity of the Medical College Admission Test for Predicting MD-PhD Student Outcomes

    Science.gov (United States)

    Bills, James L.; VanHouten, Jacob; Grundy, Michelle M.; Chalkley, Roger; Dermody, Terence S.

    2016-01-01

    The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD-PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training performance measures and career outcomes for MD-PhD students at a single institution. The study population consisted of 153 graduates of the…

  8. 77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2012-06-12

    ... Enforcement Administration Donald Brooks Reece II, M.D.; Dismissal of Proceeding On November 19, 2010, the... Order to Show Cause to Donald Brooks Reece II, M.D. (Respondent), of Morehead City, N.C. The Order... Donald Brooks Reece II, M.D., be, and it hereby is, dismissed. This Order is effective immediately. Dated...

  9. 75 FR 52461 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2010-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 ] Bridge across the Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill MD, has a...

  10. 77 FR 42464 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-07-19

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Proposed rule; withdrawal... ``Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD'' in the... Channel, in Prince George's County, MD, effective from 5 a.m. until 11 a.m. on August 5, 2012. The...

  11. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  12. StandsSIM-MD: a Management Driven forest SIMulator

    Energy Technology Data Exchange (ETDEWEB)

    Barreiro, S.; Rua, J.; Tomé, M.

    2016-07-01

    Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

  13. Prompt neutron emission from the spontaneous fission of 260Md

    Science.gov (United States)

    Wild, J. F.; van Aarle, J.; Westmeier, W.; Lougheed, R. W.; Hulet, E. K.; Moody, K. J.; Dougan, R. J.; Koop, E.-A.; Glaser, R. E.; Brandt, R.; Patzelt, P.

    1990-02-01

    We have made the first measurement of the number of neutrons emitted from the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of 254Es, we produced a large sample of 28-d 260Md, which was neutron counted in a 1-m-diameter spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58+/-0.11, substantially less than for other actinides. A linear dependence of neutron multiplicity on fragment-excitation energy is observed to the highest values of total kinetic energy.

  14. Edmund Burke, the Atlantic American war and the ‘poor Jews at St. Eustatius’. Empire and the law of nations

    Directory of Open Access Journals (Sweden)

    Guido Abbattista

    2008-01-01

    Full Text Available This essay is devoted to a relatively minor episode in Edmund Burke’s parliamentary career and political speculation involving the rights of war and international law in the final years of the American War of Independence. The starting point for Burke’s consideration of these questions was the affair of St. Eustatius, that is to say Britain’s conquest in 1781 of the Dutch West-Indian island early in the “fourth Anglo-Dutch War” of 1780-1784. The harsh treatment of the Dutch colony’s cosmopolitan community by the commanding officers of the British Navy and Army provoked a series of reactions in Britain and the colonies. The essay starts by outlining the identity of St. Eustatius with its economic, demographic and social features, its peculiar role in the eighteenth-century West Indies and its emblematic meaning in the historical literature of the Enlightenment as a symbol of the virtues of commerce and of economic liberty. It goes on to analyse the facts of the military conquest in 1781 and the ensuing occupation realized by Admiral George Rodney and Major-General John Vaughan, particularly as this affected the “poor Jews at St. Eustatius” (as Burke himself qualified them in his second speech on 4 December 1781, with the subsequent reactions of the Dutch and especially the British Atlantic world. We then examine Edmund Burke’s reasons for taking up this affair, including the political and ideological motives and the sources of arguments he used in the two parliamentary speeches he made on the topic during 1781, relating this to Burke’s ideas on international relations and imperial government during the 1770s and 1780s. We end by pointing to cultural links between Burke’s positions and a wider political, commercial and civic culture emerging in the British Atlantic world which reflected some of the most typical European Enlightenment values and ideological commitments.

  15. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    logistic processes are developed. In the aesthetic part of the project, the aesthetic qualities of using textiles in hospital interiors are explored and accentuated through a theoretical framework, related to the concept of atmospheres. Familiarity and tactility are here deduced as two main design......The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... environments. However, in architectural and design related theory, materials are linked closely to the perceived atmosphere of spaces, and a better awareness on the aesthetic material qualities are considered needed to accommodate the visions of healing architecture. Traditional textiles that earlier have been...

  16. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Strategies to Build Authorship Competence Among PhD Students.

    Science.gov (United States)

    Conn, Vicki S; Jefferson, Urmeka; Cohen, Marlene Z; Anderson, Cindy M; Killion, Cheryl M; Fahrenwald, Nancy L; Benefield, Lazelle E; Titler, Marita; Topp, Robert; Smith, Carol E; Loya, Julio

    2016-06-07

    Publication in refereed journals is an important responsibility of PhD-prepared nurses. Specialized writing skills are crucial for effective professional publication. The capacity to develop and publish articles is best learned during doctoral education. This Western Journal of Nursing Research Editorial Board Special Article addresses multi-dimensional strategies to develop authorship competence among doctoral students. The article outlines structured PhD program experiences to provide the context for students to develop authorship capacity. The authors identify multi-faceted faculty endeavors and student activities that are essential to foster authorship competence. Students who embrace opportunities to acquire authorship qualifications will be well prepared for their post-graduation role as stewards of the nursing discipline. © The Author(s) 2016.

  18. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  19. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  20. Saul Hertz, MD, and the birth of radionuclide therapy.

    Science.gov (United States)

    Fahey, Frederic H; Grant, Frederick D; Thrall, James H

    2017-12-01

    The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School where Karl Compton, PhD, president of the Massachusetts Institute of Technology was invited to give a presentation entitled "What Physics Can Do for Biology and Medicine." Saul Hertz who attended the luncheon spontaneously asked the very pertinent question that perhaps changed the course of treatment of thyroid disease, "Could iodine be made radioactive artificially?" We review the events leading up to the asking of this question, the preclinical investigations by Dr. Hertz and his colleague Arthur Roberts prior to the treatment of the first patient and what occurred in the years following this landmark event. This commentary seeks to set the record straight to the sequence of events leading to the first radioiodine therapy, so that those involved can be recognized with due credit.

  1. Preparing Physics Ph.D. Students as Instructors

    Science.gov (United States)

    Manhart, Michael; Knapen, Simon

    2012-03-01

    As demand grows for education in STEM fields, there is an increasing need for Ph.D. physicists with a strong aptitude for and commitment to teaching. Development of these skills begins in graduate school, where most physicists are first exposed to teaching as TAs to undergraduate courses. The TA experience thus has considerable impact on the development of their teaching skills. Unfortunately, many graduate programs do not provide detailed training to their TAs. However, if departments hope to produce physicists who are also outstanding educators, they must create a culture of excellence in teaching that includes adequate training and incentives to excel for their graduate student TAs. As current Ph.D. students in the Department of Physics and Astronomy at Rutgers University, we have designed and implemented a TA training program to achieve these goals. Our program, Developing Educational Leaders among TAs in Physics (DELTA P), is aimed at new physics TAs and consists of an intensive orientation followed by 10 weekly seminars during the semester. The orientation focuses on the essential practical issues relevant to TAs before they first step in the classroom, while the seminars delve into more specialized topics, ranging from motivating non-majors to physics education research. Students who complete the program are given an official credential by the department to certify their training. After two years DELTA P has begun to effect positive changes to our department's TA experience, and we believe DELTA P serves as a useful model for other departments. In this talk, we will present our program and hope to engage in an interactive discussion with the audience about these issues.

  2. Quasiequivalence of multiscale coevolution and ensemble MD simulations: A demonstration with lactoferrin

    Science.gov (United States)

    Yang, J.; Singharoy, A.; Sereda, Yu. V.; Ortoleva, P. J.

    2014-11-01

    Ensemble molecular dynamics computations are performed because a single MD simulation may not represent all the possible scenarios. Ensemble MD consumes a great amount of resources. Here, the similarity of ensemble MD and coupled all-atom, coarse-grained simulation (the multiscale coevolution method) is assessed. Quasiequivalence of two simulations is defined and shown to provide a similarity measure. Quasiequivalence compares trajectories on coarse and relatively finer scales. Good agreement between multiscale coevolution and ensemble MD simulations is demonstrated for lactoferrin. Quasiequivalence along with greater CPU efficiencies of multiscale coevolution relative to ensemble MD, underscore the advantages of multiscale coevolution for nanosystem modeling.

  3. Pipelines or pipe dreams? PhD production and other matters in a ...

    African Journals Online (AJOL)

    This retrospective study documents the Masters and PhD training of 131 Dental Research Institute (DRI) postgraduates (1954-2006) to establish demographics, throughput and research outcomes for future PhD pipeline strategies using the DRI database. Descriptive statistics show four degree-based groups of ...

  4. A model perception on the independence of PhD students in ...

    African Journals Online (AJOL)

    It is familiar that PhD students from University of Rwanda (UR) are used to rely on their supervisors and Faculty members. In this paper we perceive the importance of training the PhD student to be independent researcher from the beginning of doctoral studies until the successful completion by suggesting a supervision ...

  5. Undertaking the Journey Together: Peer Learning for a Successful and Enjoyable PhD Experience

    Science.gov (United States)

    Stracke, Elke

    2010-01-01

    This paper deals with the challenge of supervising PhD students. Any supervision is likely to constitute a challenging experience for the supervisor, even more so when they are a new academic staff member with little experience in PhD supervision in the Australasian context. This paper shows how one supervisor addressed the challenge by fostering…

  6. The Undergraduate Origins of PhD Economists: The Berkeley Experience

    Science.gov (United States)

    Olney, Martha L.

    2015-01-01

    The University of California, Berkeley sends more undergraduate students to economics PhD programs than any other public university. While this fact is surely a function of its size, there may be lessons from the Berkeley experience that others could adopt. To investigate why Berkeley generates so many economics PhD students, the author convened…

  7. Iranian PhD Students' Beliefs about Language Learning and Teaching: A Qualitative Study

    Science.gov (United States)

    Pishghadam, Reza; Pourali, Shahrzad

    2011-01-01

    Employing metaphor analysis, the present study explores the nature of unconscious beliefs of PhD students. This research aims at analyzing the metaphors produced by Iranian PhD students about learning and teaching in both current and ideal situations. Using the Iranian context of education, this study intended to: first, collecting the metaphors…

  8. Digital Doctorates? An Exploratory Study of PhD Candidates' Use of Online Tools

    Science.gov (United States)

    Dowling, Robyn; Wilson, Michael

    2017-01-01

    Online environments are transforming learning, including doctoral education. Yet the ways in which the PhD experience is shaped and transformed through these digital modes of engagement is seldom addressed, and not systematically understood. In this article, we explore PhD students' perceptions and use of digital tools. Drawing on the results of…

  9. Differing Motivations and Requirements in PhD Student Cohorts: A Case Study

    Science.gov (United States)

    Naylor, Ryan; Chakravarti, Sumone; Baik, Chi

    2016-01-01

    The PhD student experience is an increasingly important area of education research in Australia and internationally. Although many factors supporting the PhD experience have been identified, there has been a tendency towards examining the issue through a cohort-wide lens, in which the nuances of experience of smaller groups and individuals may be…

  10. Intercultural PhD Supervision: Exploring the Hidden Curriculum in a Social Science Faculty Doctoral Programme

    Science.gov (United States)

    Kidman, Joanna; Manathunga, Catherine; Cornforth, Sue

    2017-01-01

    International knowledge markets rely heavily on a ready supply of highly mobile doctoral students, many of whom are from the global South, to bring in revenue. The supervision of these PhD students, however, can reproduce neo-colonial knowledge relations, often in subtle ways. In settler nations, international PhD students may find that they are…

  11. Searching for "A Third Space": A Creative Pathway towards International PhD Students' Academic Acculturation

    Science.gov (United States)

    Elliot, Dely Lazarte; Baumfield, Vivienne; Reid, Kate

    2016-01-01

    Undertaking a PhD is a challenging endeavour. Pursuing a doctoral education in a "foreign" context tends to increase the demands of this intellectual venture. The nature of research-based PhD programmes, often characterised by a lack of formal curricula where academic supervision lasts several years, may add another layer of complexity.…

  12. A fast ellipse extended target PHD filter using box-particle implementation

    Science.gov (United States)

    Zhang, Yongquan; Ji, Hongbing; Hu, Qi

    2018-01-01

    This paper presents a box-particle implementation of the ellipse extended target probability hypothesis density (ET-PHD) filter, called the ellipse extended target box particle PHD (EET-BP-PHD) filter, where the extended targets are described as a Poisson model developed by Gilholm et al. and the term ;box; is here equivalent to the term ;interval; used in interval analysis. The proposed EET-BP-PHD filter is capable of dynamically tracking multiple ellipse extended targets and estimating the target states and the number of targets, in the presence of clutter measurements, false alarms and missed detections. To derive the PHD recursion of the EET-BP-PHD filter, a suitable measurement likelihood is defined for a given partitioning cell, and the main implementation steps are presented along with the necessary box approximations and manipulations. The limitations and capabilities of the proposed EET-BP-PHD filter are illustrated by simulation examples. The simulation results show that a box-particle implementation of the ET-PHD filter can avoid the high number of particles and reduce computational burden, compared to a particle implementation of that for extended target tracking.

  13. Enhancing the Industrial PhD Programme as a Policy Tool for University-Industry Cooperation

    Science.gov (United States)

    Roolaht, Tõnu

    2015-01-01

    The changing role of universities in society includes the increasing expectation that academic institutions should engage in collaboration with companies. Industrial PhD programmes are educational tools for building bridges between the academic sector and industry. In these programmes, the PhD student studies and carries out research while being…

  14. A networked pathway to the PhD: The African-Norwegian case of ...

    African Journals Online (AJOL)

    How do PhD students become socialised into the professional world of academic work? This article pays attention to a 'networked' support pathway towards a PhD. The network constitutes an international research collaboration through a programme called Productive Learning Cultures (PLC) (2002-2011) between Norway ...

  15. In Memoriam: Amar J.S. Klar, Ph.D. | Center for Cancer Research

    Science.gov (United States)

    In Memoriam: Amar J.S. Klar, Ph.D. The Center for Cancer Research mourns the recent death of colleague and friend Amar J.S. Klar, Ph.D.  Dr. Klar was a much-liked and respected member of the NCI community as part of the Gene Regulation and Chromosome Biology Laboratory since 1988.

  16. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  17. NOTES ON CONTRIBUTORS Segun Joshua (PhD) is senior lecturer ...

    African Journals Online (AJOL)

    Admin

    Segun Joshua (PhD) is senior lecturer at the Department of Political Science and International Relations, Covenant. University, Ota, Ogun State, Nigeria. joshuasegun2003@yahoo.com. Idowu Biao (PhD) is Professor of Lifelong Learning at the Department of Adult Education, University of Botswana. He has served as Ag.

  18. Creating Entrepreneurial Networks: Academic Entrepreneurship, Mobility and Collaboration during PhD Education

    Science.gov (United States)

    Bienkowska, Dzamila; Klofsten, Magnus

    2012-01-01

    Network-building activities of PhD students are an important area of study in furthering our understanding of academic entrepreneurship. This paper focuses on PhD students' participation in network-building activities defined as mobility and collaboration, as well as own interest in and perceived grade of support for commercialisation from various…

  19. NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

    Science.gov (United States)

    Howard, Sunnie

    1998-01-01

    The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the

  20. Multi-Target Detection from Full-Waveform Airborne Laser Scanner Using Phd Filter

    Science.gov (United States)

    Fuse, T.; Hiramatsu, D.; Nakanishi, W.

    2016-06-01

    We propose a new technique to detect multiple targets from full-waveform airborne laser scanner. We introduce probability hypothesis density (PHD) filter, a type of Bayesian filtering, by which we can estimate the number of targets and their positions simultaneously. PHD filter overcomes some limitations of conventional Gaussian decomposition method; PHD filter doesn't require a priori knowledge on the number of targets, assumption of parametric form of the intensity distribution. In addition, it can take a similarity between successive irradiations into account by modelling relative positions of the same targets spatially. Firstly we explain PHD filter and particle filter implementation to it. Secondly we formulate the multi-target detection problem on PHD filter by modelling components and parameters within it. At last we conducted the experiment on real data of forest and vegetation, and confirmed its ability and accuracy.

  1. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

    Directory of Open Access Journals (Sweden)

    Inmaculada Segura

    2016-03-01

    Full Text Available Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs, and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the actin cross-linker filamin A (FLNA as a target of PHD2 mediating these effects. In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL-mediated ubiquitination and proteasomal degradation. In hypoxia, PHD2 inactivation rapidly upregulates FLNA protein levels because of blockage of its proteasomal degradation. FLNA upregulation induces more immature spines, whereas Flna silencing rescues the immature spine phenotype induced by PHD2 inhibition.

  2. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

    Science.gov (United States)

    Segura, Inmaculada; Lange, Christian; Knevels, Ellen; Moskalyuk, Anastasiya; Pulizzi, Rocco; Eelen, Guy; Chaze, Thibault; Tudor, Cicerone; Boulegue, Cyril; Holt, Matthew; Daelemans, Dirk; Matondo, Mariette; Ghesquière, Bart; Giugliano, Michele; Ruiz de Almodovar, Carmen; Dewerchin, Mieke; Carmeliet, Peter

    2016-01-01

    Summary Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature filopodium-like dendritic protrusions, promote spine regression, reduce synaptic density, and decrease the frequency of spontaneous action potentials independently of HIF signaling. We identified the actin cross-linker filamin A (FLNA) as a target of PHD2 mediating these effects. In normoxia, PHD2 hydroxylates the proline residues P2309 and P2316 in FLNA, leading to von Hippel-Lindau (VHL)-mediated ubiquitination and proteasomal degradation. In hypoxia, PHD2 inactivation rapidly upregulates FLNA protein levels because of blockage of its proteasomal degradation. FLNA upregulation induces more immature spines, whereas Flna silencing rescues the immature spine phenotype induced by PHD2 inhibition. PMID:26972007

  3. MULTI-TARGET DETECTION FROM FULL-WAVEFORM AIRBORNE LASER SCANNER USING PHD FILTER

    Directory of Open Access Journals (Sweden)

    T. Fuse

    2016-06-01

    Full Text Available We propose a new technique to detect multiple targets from full-waveform airborne laser scanner. We introduce probability hypothesis density (PHD filter, a type of Bayesian filtering, by which we can estimate the number of targets and their positions simultaneously. PHD filter overcomes some limitations of conventional Gaussian decomposition method; PHD filter doesn’t require a priori knowledge on the number of targets, assumption of parametric form of the intensity distribution. In addition, it can take a similarity between successive irradiations into account by modelling relative positions of the same targets spatially. Firstly we explain PHD filter and particle filter implementation to it. Secondly we formulate the multi-target detection problem on PHD filter by modelling components and parameters within it. At last we conducted the experiment on real data of forest and vegetation, and confirmed its ability and accuracy.

  4. Harvey Cushing, M.D., in his world.

    Science.gov (United States)

    Hart, Curtis W

    2014-12-01

    Harvey Cushing, M.D. (1869-1939), is the acknowledged father of the discipline of neurosurgery who inspired others to join him in this new field. He was a prolific researcher in the area of human growth disturbances. And he was among the most literary of doctors having won the Pulitzer Prize for his two-volume biography of his mentor and teacher William Osler, M.D. A driven man, he both inspired and intimidated others. This essay explores Cushing's character and background along with his relationship to Osler. It seeks to understand why and how he may be considered a great figure in spite and because of his demanding and often problematic character. It further seeks to place Cushing in the context of the transition of American society and American medicine in the latter decades of the nineteenth and early decades of the twentieth century. Portions of this essay were originally delivered as part of a Grand Rounds presentation for the Department of Neurosurgery at the New York Presbyterian Hospital Weill Cornell Center.

  5. Full-Scale Crash Test of an MD-500 Helicopter

    Science.gov (United States)

    Littell, Justin

    2011-01-01

    A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

  6. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    AUTHOR|(CDS)2078850; Amorim, David; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

  7. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  8. Effects of PhD examination stress on allopregnanolone and cortisol plasma levels and peripheral benzodiazepine receptor density.

    NARCIS (Netherlands)

    Droogleever Fortuyn, H.A.; Broekhoven, F. van; Span, P.N.; Backstrom, T.; Zitman, F.G.; Verkes, R.J.

    2004-01-01

    Peripheral benzodiazepine receptor (PBR) density in blood platelets and plasma allopregnanolone concentration in humans were determined following acute stress as represented by PhD examination. Fifteen healthy PhD students participated. Heart rate, blood pressure, plasma allopregnanolone, plasma

  9. Educating future leaders of medical research: analysis of student opinions and goals from the MD-PhD SAGE (Students' Attitudes, Goals, and Education) survey.

    Science.gov (United States)

    Ahn, Jaimo; Watt, Christopher D; Man, Li-Xing; Greeley, Siri Atma W; Shea, Judy A

    2007-07-01

    To collect national trainee-derived data about the educational process and experience of MD-PhD students. Eight hundred sixty-eight MD-PhD students enrolled in 15 training programs nationally were surveyed in spring 2003 via a 29-item Web-based questionnaire. Closed-ended questions assessed students' opinions, attitudes, and goals concerning education and future careers, as well as demographic characteristics. Programs were categorized by size; students were categorized by stage of training. Statistical analyses included chi-square tests and ANOVAs. From 13 institutions, 492 questionnaires were received, for a 57.6% response rate. Generally, satisfaction with overall education was highest at the beginning of training, lowest during graduate school, and rebounded after the PhD. Students at smaller programs were less satisfied with information received regarding future residency/career choices and coordination between training stages. Later-stage students showed greater satisfaction in obtaining the philosophical goals of their education and a different array of clinical interests than early-stage students. A majority of students chose research as their future primary activity, academic centers as their primary practice setting, and disease oriented as their future primary research activity. Many students did not agree with the current working definition of a physician-scientist. Findings indicate that students have clinical interests that develop over time, a variety of future career goals, and ambivalence concerning the appropriate balance of clinical and research activities. This information may provide a basis for future improvements in the education of MD-PhDs in the United States and abroad.

  10. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  11. Apple fruit copper amine oxidase isoforms: peroxisomal MdAO1 prefers diamines as substrates, whereas extracellular MdAO2 exclusively utilizes monoamines.

    Science.gov (United States)

    Zarei, Adel; Trobacher, Christopher P; Cooke, Alison R; Meyers, Ashley J; Hall, J Christopher; Shelp, Barry J

    2015-01-01

    4-Aminobutyrate (GABA) accumulates in apple fruit during controlled atmosphere storage. A potential source of GABA is the polyamine putrescine, which can be oxidized via copper-containing amine oxidase (CuAO), resulting in the production 4-aminobutanal/Δ(1)-pyrroline, with the consumption of O2 and release of H2O2 and ammonia. Five putative CuAO genes (MdAO genes) were cloned from apple (Malus domestica Borkh. cv. Empire) fruit, and the deduced amino acid sequences found to contain the active sites typically conserved in CuAOs. Genes encoding two of these enzymes, MdAO1 and MdAO2, were highly expressed in apple fruit and selected for further analysis. Amino acid sequence analysis predicted the presence of a C-terminal peroxisomal targeting signal 1 tripeptide in MdAO1 and an N-terminal signal peptide and N-glycosylation site in MdAO2. Transient expression of green fluorescent fusion proteins in Arabidopsis protoplasts or onion epidermal cells revealed a peroxisomal localization for MdAO1 and an extracellular localization for MdAO2. The enzymatic activities of purified recombinant MdAO1 and MdAO2 were measured continuously as H2O2 production using a coupled reaction. MdAO1 did not use monoamines or polyamines and displayed high catalytic efficiency for 1,3-diaminopropane, putrescine and cadaverine, whereas MdAO2 exclusively utilized aliphatic and aromatic monoamines, including 2-phenylethylamine and tyramine. Together, these results indicate that MdAO1 may contribute to GABA production via putrescine oxidation in the peroxisome of apple fruit under controlled atmosphere conditions. MdAO2 seems to be involved in deamination of 2-phenylethylamine, which is a step in the biosynthesis of 2-phenylethanol, a contributor to fruit flavor and flower fragrance. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  12. Modelling Research: A Collaborative Approach to Helping PhD Students Develop Higher-Level Research Skills

    Science.gov (United States)

    Garcia-Perez, Alexeis; Ayres, Robert

    2012-01-01

    A high proportion of PhD candidates in science and engineering fail to complete their degrees. This paper reports the results of a series of workshops where experienced researchers and supervisors were brought together with PhD students to discuss and develop a model of the PhD process. The objective was to help students develop a more rounded and…

  13. From a PhD to What? The Importance of the education-employment transition : Lessons from the Netherlands

    NARCIS (Netherlands)

    Yerkes, Mara; van de Schoot, Rens; Sonneveld, Hans

    2014-01-01

    The number of PhD graduates is on the rise. With the exception of Poland, all of the OECD countries experienced an increase in PhD graduates in the past decade (OECD, 2013). The increase in PhD graduates attests to a growth in knowledge and innovation, a growth that can be advantageous for academia,

  14. MD Simulation of Structural Transitions in Cristobalite Silica

    Science.gov (United States)

    Kieffer, John; Huang, Liping

    2001-03-01

    Molecular dynamics (MD) simulations, based on our charge-transfer potential, were used to simulate the phase transformation between alpha- and beta-cristobalite.* These simulations reveal the detailed transformation mechanism, in particular spatial correlations between transformed entities during incubation and progression of the transition. The transformation characteristics differ, depending on whether the transition is induced thermally or mechanically. The negative thermal expansion coefficient of beta-cristobalite has intriguing implications on the reverse transformation and the melting behavior of this substance. A better understanding of the thermo-mechanical anomalies of crystalline and amorphous silica is derived from careful analysis of the simulated atomic trajectories. * L. Duffrène and J. Kieffer, "Molecular Dynamic Simulations of the alpha-beta Phase Transition in Silica Cristobalite," J. Phys. Chem. Solids 59, 1025-1037 (1998)

  15. Medicinal Cannabis in California: An Interview with Igor Grant, MD.

    Science.gov (United States)

    Piomelli, Daniele; Grant, Igor

    2016-01-01

    Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research at the University of California, San Diego. Dr. Grant is a neuropsychiatrist who graduated from the University of British Columbia School of Medicine (1966), and received specialty training in psychiatry at the University of Pennsylvania (1967-1971), and additional training in neurology at the Institute of Neurology (1980-1981), London, U.K. Dr. Grant's academic interests focus on the effects of various diseases on brain and behavior, with an emphasis on translational studies in HIV, and drugs of abuse. He has contributed to ∼700 scholarly publications and is principal investigator of several NIH studies, including an NIDA P50 (Translational Methamphetamine AIDS Research Center-TMARC), and is codirector of the HIV Neurobehavioral Research Center (HNRC).

  16. LHC β*-reach MD: aperture measurements at small β*

    CERN Document Server

    Fuster Martinez, Nuria; Redaelli, Stefano; CERN. Geneva. ATS Department

    2017-01-01

    During this MD, performed on the 25th of July 2017, we measured the LHC aperture at top energy for β*=30 cm using the Transverse Damper (ADT) blow-up method. These measurements are part of the standard commissioning of an optics and have been performed in order to provide early on inputs for a possible change of β* later in 2017, as envisaged previously to fully profit from the additional margins introduced by the rematched phase advance between dump kickers and the TCTs (Target Collimator Tertiary). In addition to the aperture measurements, two other commissioning important tests were performed: loss maps for the nominal TCTs settings and an asynchronous dump validation with tighter TCT gaps.

  17. MD 979: Beta-beating measurements on colliding beams

    CERN Document Server

    Goncalves Jorge, Patrik; Pieloni, Tatiana; Buffat, Xavier; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fol, Elena; Langner, Andy Sven; Medina Medrano, Luis Eduardo; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2017-01-01

    The HL-LHC high brightness beams will give a large β-beating due to the head-on and long-range interactions since a beam-beam parameter of 0.01 per Interaction Point (IP) is expected. The β-heating induced by two head-on collision reaches 15%. A third IP, i.e. IP8, could bring the β-heating up to 24%. The aim of the Machine Development (MD) study was to test optics measurements with AC dipole and ADT on colliding beams at injection and to implement a correction of the β-heating due to to head-on collision in the two experiments IP1&5. Int his note, we summarize the first results of this test performed in the LHC.

  18. Impact of Carbon Nanotube on Homocysteine Clusters: MD Simulation

    Science.gov (United States)

    Raczyński, Przemysław; Górny, Krzysztof; Gburski, Zygmunt

    The role of homocysteine in the human body is not well known but its level is associated with cardiovascular disease. The pure clusters composed of n = 65 and 2500 homocysteine molecules have been studied by the computer simulation molecular dynamics (MD) method. Among the anticipated applications of the carbon nanotubes is their use in biological sensors, particularly homocysteine nanosensor. We have also examined the impact of a carbon nanotube on the homocysteine clusters. The mean square displacement, diffusion coefficient, and radial distribution function of homocysteine have been calculated for several temperatures, including the physiological (T = 310 K). We interpret the behavior of homocysteine molecules in the pure clusters and in the clusters with carbon nanotube by a qualitative interpretation of physical observables and snapshots of instantaneous configurations.

  19. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  20. Report from LHC MD 2158: IR-nonlinear studies

    CERN Document Server

    Maclean, Ewen Hamish; Dilly, Joschua Werner; Fol, Elena; Giovannozzi, Massimo; Hofer, Michael; Malina, Lukas; Persson, Tobias Hakan Bjorn; Coello De Portugal - Martinez Vazquez, Jaime Maria; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; Garcia-Tabares Valdivieso, Ana; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2017-01-01

    For the first time the LHC is running for luminosity-production with local corrections for nonlinear errors in the ATLAS and CMS insertions. While a major step forward in LHC optics commissioning strategy (and one which has yielded clear operational benefits) considerable challenges remain to be overcome, both in regard to the optimization of LHC optics and in order to ensure successful commissioning of the High-Luminosity LHC. MD 2158 sought to follow up several aspects of the 2017 nonlinear optics commissioning which are not yet understood, and by enhancing sextupole and dodecapole sources in the ATLAS and CMS insertions explore the prospects for linear and nonlinear optics commissioning in the HL-LHC.

  1. A workshop on leadership for MD/PhD students.

    Science.gov (United States)

    Ciampa, Erin J; Hunt, Aubrey A; Arneson, Kyle O; Mordes, Daniel A; Oldham, William M; Vin Woo, Kel; Owens, David A; Cannon, Mark D; Dermody, Terence S

    2011-01-01

    Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP) developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  2. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  3. Partnership for development: A peer mentorship model for PhD students.

    Science.gov (United States)

    Lewinski, Allison A; Mann, Tara; Flores, Dalmacio; Vance, Ashlee; Bettger, Janet Prvu; Hirschey, Rachel

    Formal mentoring relationships socialize Doctor of Philosophy (PhD) students to their current and future roles as nursing scholars. Despite formal mentoring, some students may desire or benefit from additional mentoring in an informal setting. Informal mentoring complements the one-to-one relationship students develop with a primary faculty mentor or dissertation chair. This manuscript describes the development, implementation, and evaluation of a student-driven, peer mentorship model, titled Partnership for Development. This small group, peer mentorship model was implemented in a PhD program at a School of Nursing during an academic year. Five student peer facilitators organized a total of 32 PhD students, 2 post-doctoral associates, and invited 5 faculty to participate. Data includes pre- and post-implementation surveys completed by the students and peer facilitator field notes. Student reported post-participation benefits included: getting to know faculty in an informal setting (n=6), socializing with students from other cohorts (n=6), and obtaining a sense of camaraderie with other PhD students (n=5). We recommend peer mentorship for other PhD programs as a way to socialize PhD students into the role of nurse scientist and assist students during their tenure as a PhD student. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Academic and research misconduct in the PhD: issues for students and supervisors.

    Science.gov (United States)

    Mitchell, Theresa; Carroll, Jude

    2008-02-01

    There are many pressures upon PhD students not least the requirement to make an original or significant contribution to knowledge. Some students, confronted with complex research processes, might adopt practices that compromise standards that are unacceptable within a research community. These practices challenge the PhD student-supervisor relationship and have implication for the individual, the supervisory team, the institution, the awarding body and the wider research context. Discussion relating to misconduct within the PhD is of international importance if the aim is to encourage and facilitate rigorous research practice. Cases involving academic and research misconduct, especially those occurring at PhD level, are likely to become more frequent as numbers of PhD students increase and will demand appropriate, defensible responses from supervisors. Misconduct during PhD study can be difficult to resolve because of lack of clarity in definitions, supervisor naiveté and failure to acknowledge students' decision making limitations. Using scenarios from the first author's supervisory practice to illustrate issues of concern for students and supervisors during PhD supervision, the authors aim to illuminate the importance of engagement with regulatory bodies; problems of knowledge and understanding transfer; culturally specific issues and meanings of academic theft.

  5. Integrative research on environmental and landscape change: PhD students' motivations and challenges.

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2009-07-01

    The growing demand for integrative (interdisciplinary or transdisciplinary) approaches in the field of environmental and landscape change has increased the number of PhD students working in this area. Yet, the motivations to join integrative projects and the challenges for PhD students have so far not been investigated. The aims of this paper were to identify the understanding of PhD students with regard to integrative research, their motivations to join integrative projects, their expectations in terms of integration and results, and to reveal the challenges they face in integrative projects. We collected data by a questionnaire survey of 104 PhD students attending five PhD Master Classes held from 2003 to 2006. We used manual content analysis to analyse the free-text answers. The results revealed that students lack a differentiated understanding of integrative approaches. The main motivations to join integrative projects were the dissertation subject, the practical relevance of the project, the intellectual stimulation of working with different disciplines, and the belief that integrative research is more innovative. Expectations in terms of integration were high. Core challenges for integration included intellectual and external challenges such as lack of knowledge of other disciplines, knowledge transfer, reaching depth, supervision, lack of exchange with other students and time demands. To improve the situation for PhD students, we suggest improving knowledge on integrative approaches, balancing practical applicability with theoretical advancement, providing formal introductions to other fields of research, and enhancing institutional support for integrative PhD projects.

  6. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  7. DIALLEL ANALYSIS OF RESISTANCE TO BACTERIAL STALK ROT (Pectobacterium chrysanthemi pv. zeae Burk., McFad. and Dim. IN CORN (Zea mays L.

    Directory of Open Access Journals (Sweden)

    Nuning A. Subekti

    2016-10-01

    Full Text Available One of the major disease problems affecting maize farming in the Philippines is bacterial stalk rot (BSR caused by Pectobacterium chrysanthemi pv. zeae Burk., McFad. and Dim., which is formerly known as Erwinia chrysanthemi. The annual loss due to BSR is estimated at PhP. 20 million equivalent to Rp3.5 billion. At present, there is no effective control method against BSR and, therefore, varietal improvement through breeding resistant germplasms is needed. The present study aimed to determine the combining ability and the extent of additive and non-additive genetic effects in corn inbred lines with a range of reaction to BSR. Four resistant lines (S3YB 137-1-1-B, TUPI (S3 5-1-B, TUPI (S3 15-2-B, and 97-835 and two susceptible lines (CML 295 and 97-733 were used as genetic materials. Generation of test entries and evaluation of disease resistance were conducted at the experimental farm station of University of the Philippines Los Banos and Institute of Plant Breeding Los Banos, respectively, during 2002 to 2003 wet seasons. Griffing’s diallel mating system Model 1, Method 1 was followed in generating the test entries to make a total of 36 entries (six selfed parental lines and 15 each of F1 crosses and their reciprocalcrosses. The entries were then evaluated for disease resistance in a yield trial following a randomized complete block design (RCBD with two replications. Results of diallel analysisshowed two lines, S3YB 137-1-1-B and TUPI (S3 5-1-B, exhibited the best general combining ability (GCA for resistance to BSR, while the crosses S3YB 137-1-1-B x TUPI (S3 5-1-B and TUPI (S3 5-1-B x 97-835 performed the best specific combining ability (SCA for the resistance. GCA effect was greater than that of SCA. This indicated that additive gene effects were found to be more important than non-additive gene effects in the expression of resistance to BSR in the six corn lines used. Therefore, breeding programs towards

  8. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Gang G.; Song, Jikui; Wang, Zhanxin; Dormann, Holger L.; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J.; Allis, C. David; (MSKCC); (Scripps); (Rockefeller)

    2009-07-21

    Histone H3 lysine4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  9. Experiences of International PhD Students in Denmark as Quest Stories

    DEFF Research Database (Denmark)

    Maksimovic, Tijana; Kobayashi, Sofie

    2017-01-01

    This article explores how the metaphor of quest can be used to conceptualise PhD experience and be employed in PhD supervision practice. As part of a small-scale study of the PhD experience of international students in Denmark, whose numbers have significantly increased lately, we conducted...... narrative interviews with 9 doctoral students. They were asked to select and describe up to 5 photographs that represent what they will remember their PhDs by. These narratives were first analysed inductively and then deductively organised using the quest metaphor. The findings indicate that the quest...

  10. Creating entrepreneurial networks : academic entrepreneurship, mobility and collaboration during PhD education

    OpenAIRE

    Bienkowska, Dzamila; Klofsten, Magnus

    2012-01-01

    Network-building activities of PhD students are an important area of study in furthering our understanding of academic entrepreneurship. This paper focuses on PhD students’ participation in network-building activities defined as mobility and collaboration, as well as own interest in and perceived grade of support for commercialisation from various levels of the university hierarchy. The results of a large-scale survey (of 1,126 PhD students at Linköping University, Sweden, 41% response rate) ...

  11. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation...... evolutionary origin for the phd/doc operon. Doc induces growth arrest of Escherichia coli cells in a reversible manner, by targeting the protein synthesis machinery. Moreover, Doc activates the endogenous E. coli RelE mRNA interferase but does not require this or any other known chromosomal toxin...

  12. MD-TASK: a software suite for analyzing molecular dynamics trajectories.

    Science.gov (United States)

    Brown, David K; Penkler, David L; Sheik Amamuddy, Olivier; Ross, Caroline; Atilgan, Ali Rana; Atilgan, Canan; Tastan Bishop, Özlem

    2017-09-01

    Molecular dynamics (MD) determines the physical motions of atoms of a biological macromolecule in a cell-like environment and is an important method in structural bioinformatics. Traditionally, measurements such as root mean square deviation, root mean square fluctuation, radius of gyration, and various energy measures have been used to analyze MD simulations. Here, we present MD-TASK, a novel software suite that employs graph theory techniques, perturbation response scanning, and dynamic cross-correlation to provide unique ways for analyzing MD trajectories. MD-TASK has been open-sourced and is available for download from https://github.com/RUBi-ZA/MD-TASK , implemented in Python and supported on Linux/Unix. o.tastanbishop@ru.ac.za.

  13. Analysis of MD5 authentication in various routing protocols using simulation tools

    Science.gov (United States)

    Dinakaran, M.; Darshan, K. N.; Patel, Harsh

    2017-11-01

    Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

  14. Evidence for ProTα-TLR4/MD-2 binding: molecular dynamics and gravimetric assay studies.

    Science.gov (United States)

    Omotuyi, Olaposi; Matsunaga, Hayato; Ueda, Hiroshi

    2015-01-01

    During preconditioning, lipopolysaccharide (LPS) selectively activates TLR4/MD-2/Toll/IL-1 receptor-domain-containing adaptor inducing IFN-β (TRIF) pathway instead of pro-inflammatory myeloid differentiation protein-88 (MyD88)/MyD88-adaptor-like protein (MAL) pathway. Extracellular prothymosin alpha (ProTα) is also known to selectively activate the TLR4/MD2/TRIF-IRF3 pathway in certain diseased conditions. In the current study, biophysical evidence for ProTα/TLR4/MD-2 complex formation and its interaction dynamics have been studied. Gravimetric assay was used to investigate ProTα/TLR4/MD-2 complex formation while molecular dynamics (MD) simulation was used to study its interaction dynamics. Through electrostatic interaction, full-length ProTα (F-ProTα) C-terminal peptide (aa 91 - 111) superficially interacts with similar TLR4/MD-2 (KD = 273.36 nm vs 16.07 μg/ml [LPS]) conformation with LPS at an overlapping three-dimensional space while F-ProTα is hinged to the TLR4 scaffold by one-amino acid shift-Mosoian domain (aa-51 - 90). Comparatively, F-ProTα better stabilizes MD-2 metastable states transition and mediates higher TLR4/MD-2 interaction than LPS. ProTα via its C-terminal peptide (aa 91 - 111) exhibits in vitro biophysical contact with TLR4/MD-2 complex conformation recognized by LPS at overlapping LPS-binding positions.

  15. The 8th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    1998-01-01

    Each year since 1991 there has been a workshop for PhD students at the ECOOP conference. It is every every year conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS), hence it is an event for PhD students by PhD students. The purpose of the PhDOOS network is to help...... leveraging the collective resources of young researchers in the object community by improving the communication and collaboration between them. During a year, the PhDOOS workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information...

  16. Trends in landscape research and landscape planning : implications for PhD students

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Antrop, M.

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  17. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  18. Comparison of Basic Science Knowledge Between DO and MD Students.

    Science.gov (United States)

    Davis, Glenn E; Gayer, Gregory G

    2017-02-01

    With the coming single accreditation system for graduate medical education, medical educators may wonder whether knowledge in basic sciences is equivalent for osteopathic and allopathic medical students. To examine whether medical students' basic science knowledge is the same among osteopathic and allopathic medical students. A dataset of the Touro University College of Osteopathic Medicine-CA student records from the classes of 2013, 2014, and 2015 and the national cohort of National Board of Medical Examiners Comprehensive Basic Science Examination (NBME-CBSE) parameters for MD students were used. Models of the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) Level 1 scores were fit using linear and logistic regression. The models included variables used in both osteopathic and allopathic medical professions to predict COMLEX-USA outcomes, such as Medical College Admission Test biology scores, preclinical grade point average, number of undergraduate science units, and scores on the NBME-CBSE. Regression statistics were studied to compare the effectiveness of models that included or excluded NBME-CBSE scores at predicting COMLEX-USA Level 1 scores. Variance inflation factor was used to investigate multicollinearity. Receiver operating characteristic curves were used to show the effectiveness of NBME-CBSE scores at predicting COMLEX-USA Level 1 pass/fail outcomes. A t test at 99% level was used to compare mean NBME-CBSE scores with the national cohort. A total of 390 student records were analyzed. Scores on the NBME-CBSE were found to be an effective predictor of COMLEX-USA Level 1 scores (PNBME-CBSE scores (PNBME-CBSE between osteopathic and allopathic medical students (P=.322). As an examination constructed to assess the basic science knowledge of allopathic medical students, the NBME-CBSE is effective at predicting performance on COMLEX-USA Level 1. In addition, osteopathic medical students performed the same as allopathic medical

  19. Política, religião, revolução e soberania em Reflexões sobre a revolução em França do conservador E. Burke

    Directory of Open Access Journals (Sweden)

    Raquel Kritsch

    2011-08-01

    Full Text Available

    O objetivo deste artigo é introduzir ao leitor o pensamento político de Edmund Burke, um dos nomes mais influentes do pensamento político conservador. A partir de uma breve contextualização da crítica burkeana ao racionalismo iluminista, o artigo procura mostrar como o autor organiza conceitos centrais de sua teoria política, como poder, legitimidade, conservação, correção, preconceito, prescrição, num discurso articulado e coerente, com o objetivo de sustentar que na Inglaterra política e religião constituem, juntas, não só a base não só da prosperidade do povo mas também o fundamento do Estado. Em seguida, aborda-se a crítica de Burke à Revolução Francesa, à “psicologia dos revolucionários” e, de maneira mais detida, aos direitos do homem, discutindo alguns de seus argumentos contra as abstrações distanciadas das práticas concretas dos coletivos humanos e a transformação da metafísica moderna num programa político.

  20. Report on the International PhD School ''Science and Technology with the E-ELT''

    Science.gov (United States)

    Bono, G.; Hook, I.; Ramsay, S.

    2015-12-01

    This international PhD school in the F. Lucchin cycle was the first to bring together Masters and PhD students with an interest in all aspects of the science and technology of the European Extremely Large Telescope (E-ELT). It was fitting that this school was held within a year of the project formally entering the construction phase. An overview of the topics covered during the school is presented.

  1. Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

    Science.gov (United States)

    Loges, Sonja; Schmidt, Thomas; Jonckx, Bart; Tian, Ya-Min; Lanahan, Anthony A.; Pollard, Patrick; de Almodovar, Carmen Ruiz; De Smet, Frederik; Vinckier, Stefan; Aragonés, Julián; Debackere, Koen; Luttun, Aernout; Wyns, Sabine; Jordan, Benedicte; Pisacane, Alberto; Gallez, Bernard; Lampugnani, Maria Grazia; Dejana, Elisabetta; Simons, Michael; Ratcliffe, Peter; Maxwell, Patrick; Carmeliet, Peter

    2014-01-01

    SUMMARY A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2+/− mice. Haplodeficiency of PHD2 did not affect tumor vessel density or lumen size, but normalized the endothelial lining and vessel maturation. This resulted in improved tumor perfusion and oxygenation and inhibited tumor cell invasion, intravasation, and metastasis. Haplodeficiency of PHD2 redirected the specification of endothelial tip cells to a more quiescent cell type, lacking filopodia and arrayed in a phalanx formation. This transition relied on HIF-driven upregulation of (soluble) VEGFR-1 and VE-cadherin. Thus, decreased activity of an oxygen sensor in hypoxic conditions prompts endothelial cells to readjust their shape and phenotype to restore oxygen supply. Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy. PMID:19217150

  2. MD#1182: Calibration of diamond particle detectors in IP6

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Wiesner, Christoph

    2017-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IP6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the movable dump protection absorber (TCDQ) downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with an dynamic range of several orders of magnitude; thus, allowing to know the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. The impact parameter of the bunches on the TCDQ was first scanned using probe bunches with lower intensity then tests were done with nominal bunches (1.1e11 p/bunch) at injection energy. High energy calibration of the losses was also attempted unsuccessfully. Due to different beh...

  3. BayesMD: flexible biological modeling for motif discovery.

    Science.gov (United States)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-12-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on transcription factor (TF) databases in order to extract the typical properties of TF binding sites. In a similar fashion we train organism-specific priors for the background sequences. Lastly, we use a prior over the position of binding sites. This prior represents information complementary to the motif and background priors coming from conservation, local sequence complexity, nucleosome occupancy, etc. and assumptions about the number of occurrences. The Bayesian inference is carried out using a combination of exact marginalization (multinomial parameters) and sampling (over the position of sites). Robust sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.

  4. Using MD Simulations To Calculate How Solvents Modulate Solubility.

    Science.gov (United States)

    Liu, Shuai; Cao, Shannon; Hoang, Kevin; Young, Kayla L; Paluch, Andrew S; Mobley, David L

    2016-04-12

    Here, our interest is in predicting solubility in general, and we focus particularly on predicting how the solubility of particular solutes is modulated by the solvent environment. Solubility in general is extremely important, both for theoretical reasons - it provides an important probe of the balance between solute-solute and solute-solvent interactions - and for more practical reasons, such as how to control the solubility of a given solute via modulation of its environment, as in process chemistry and separations. Here, we study how the change of solvent affects the solubility of a given compound. That is, we calculate relative solubilities. We use MD simulations to calculate relative solubility and compare our calculated values with experiment as well as with results from several other methods, SMD and UNIFAC, the latter of which is commonly used in chemical engineering design. We find that straightforward solubility calculations based on molecular simulations using a general small-molecule force field outperform SMD and UNIFAC both in terms of accuracy and coverage of the relevant chemical space.

  5. The future of the orthopaedic clinician-scientist. Part I: The potential role of MD-PhD students considering orthopaedic surgery.

    Science.gov (United States)

    Ahn, Jaimo; Man, Li-Xing; Wanderer, Jonathan; Bernstein, Joseph; Iannotti, Joseph P

    2008-08-01

    There is currently a severe shortage of clinician-scientists, who fill a vital role in musculoskeletal care. One way to address this shortage is to recruit more MD-PhD students into orthopaedics. We analyzed data from a national survey of MD-PhD students to assess this potential. A total of 868 students from thirteen MD-PhD training programs were requested to fill out a multiple-choice online survey concerning their education and future goals. We achieved a response rate of 56.7% (492 of 868). Seven (1.4%) of the 492 respondents listed orthopaedics as their primary clinical interest, and thirty (6.1%) listed it as one of their three strongest clinical interests. Among the thirty respondents, seven (23%) were senior students, five (17%) were women, and none were minorities. In comparison, 33% of the 462 respondents in the nonorthopaedic cohort were women and 12.1% were a member of a minority group (p students who had a secondary orthopaedic interest, only one-third had a primary surgical interest. Both the thirty with a strong clinical interest in orthopaedics and the others without a strong interest in orthopaedics showed similar intent on becoming physician-scientists (a score of 2.73 and 3.30, respectively) and an interest in an academic career (90.0% and 90.3%, respectively) (p > 0.05 for both). The orthopaedic group showed significantly greater interest in clinical care as a primary activity than did the nonorthopaedic group (63.3% compared with 30.7%; p PhD students nationally, creating the potential to recruit approximately 100 new orthopaedic clinician-scientists every eight years (the average MD-PhD training period). Extrapolation indicates that there is the ability to double the number of orthopaedic clinician-scientists in the United States over the next fifty years. Therefore, efforts should be made to attract these students (especially women and those in underrepresented minority groups) to orthopaedic surgery. The study further suggests recruiting

  6. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are

  7. Academic Experiences of International PhD Students in Australian Higher Education: From an EAP Program to a PhD Program

    Science.gov (United States)

    Son, Jeong-Bae; Park, Sang-Soon

    2014-01-01

    For the last few decades, Australia has played a pivotal role in the supply of quality education to international students and other educational industries associated with them. In the higher education sector, in particular, international PhD student numbers continue to increase. However, the limited availability of resources for the students and…

  8. Preparing for Graduate-Level Training in Professional Psychology: Comparisons across Clinical PhD, Counseling PhD, and Clinical PsyD Programs

    Science.gov (United States)

    Karazsia, Bryan T.; Smith, Lena

    2016-01-01

    In the present study, faculty who teach in clinical and counseling doctor of philosophy (PhD) or doctor of psychology (PsyD) programs completed surveys regarding preferences for prospective student preparations to graduate programs. Faculty expectations of minimum and ideal undergraduate training were highest for scientific methods, though…

  9. 77 FR 5105 - Randall L. Wolff, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-01

    ... February 1, 2012 Part III Department of Justice Drug Enforcement Administration Randall L. Wolff, M.D... / Notices#0;#0; ] DEPARTMENT OF JUSTICE Drug Enforcement Administration Randall L. Wolff, M.D.; Decision and... `` t was from football,'' that he had had back pain since ``98'' and that Dr. C. ``had it in my chart...

  10. Effectiveness of a clinical intervention for MD/PhD students re-entering medical school.

    Science.gov (United States)

    Bills, James L; Davidson, Mario; Dermody, Terence S

    2013-01-01

    For MD/PhD students, the transition to medical school following graduate research can be difficult. We developed a clinical intervention, the Clinical Preceptorship Program (CPP), for MD/PhD students at Vanderbilt to ease the transition to the core clinical clerkship year (the 3rd medical year) following graduate training. In this study, we determined whether the CPP prepared MD/PhD students adequately for medical school reentry. Clerkship grades were obtained for 680 medical students and 50 MD/PhD students for academic years 2004-2010. A student's unpaired t test was used to analyze differences between group grades. We did not detect significant differences in the grades of the MD versus MD/PhD students. No differences in individual clerkships were detected with the exception of the Surgery clerkship. These data suggest that the CPP intervention was successful in preparing MD/PhD students for the core clerkship year. Such a clinical intervention can be an effective preparation for MD/PhD students returning to medical school.

  11. Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jianping AN

    2017-03-01

    Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

  12. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... Enforcement Administration Robert Leigh Kale, M.D., Decision and Order On September 9, 2010, the Deputy... Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort Smith, Arkansas. ] The Show Cause Order....100(b) and 0.104, I order that DEA Certificate of Registration, BK9514375, issued to Robert Leigh Kale...

  13. 76 FR 16296 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2011-03-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 Bridge across Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... least five hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill...

  14. 78 FR 38000 - Special Local Regulations; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD

    Science.gov (United States)

    2013-06-25

    ...--AA08 Special Local Regulations; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD AGENCY...,'' a marine event to be held on the waters of Spa Creek and Annapolis Harbor on July 20, 2013. The...; Marine Events, Spa Creek and Annapolis Harbor; Annapolis, MD'' in the Federal Register (78 FR 20066). The...

  15. PhD students’ expectations from their supervisors: A qualitative content analysis

    Directory of Open Access Journals (Sweden)

    SH Rimaz

    2015-03-01

    Full Text Available Introduction: Quality of research in PhD programs increases if supervisors become aware of students' expectations from them. This qualitative study aimed to explore expectations of PhD students from their supervisors was done.   Methods: This qualitative content analysis study was conducted on 22 graduated PhD students of Iran University of Medical Sciences, in 2014. The samples were purposefully selected and interviewed. All interviews were recorded and transcribed verbatim.   Results: After analyzing and coding data, it was found that PhD students have four main expectations from their supervisors. These expectations consist of scientific support including help with selection of subject, preparation and registration of proposal, data collection and support for writing and examination of the thesis. Developing scientific skills and help with preparing manuscripts were other expectations. Emotional-social support with five categories including relationship between supervisor-student, general expectations of supervisor, supervisor personality characteristics, needed emotional skills and social activities related to thesis and finally providing adequate resources including financial support and access to facilities inside and outside the university were among the other expectations.   Conclusion: PhD students need to scientific, emotional, social and material supports from their supervisors in the process of performing thesis. These expectations should be told to supervisors.

  16. Predicting the "graduate on time (GOT)" of PhD students using binary logistics regression model

    Science.gov (United States)

    Shariff, S. Sarifah Radiah; Rodzi, Nur Atiqah Mohd; Rahman, Kahartini Abdul; Zahari, Siti Meriam; Deni, Sayang Mohd

    2016-10-01

    Malaysian government has recently set a new goal to produce 60,000 Malaysian PhD holders by the year 2023. As a Malaysia's largest institution of higher learning in terms of size and population which offers more than 500 academic programmes in a conducive and vibrant environment, UiTM has taken several initiatives to fill up the gap. Strategies to increase the numbers of graduates with PhD are a process that is challenging. In many occasions, many have already identified that the struggle to get into the target set is even more daunting, and that implementation is far too ideal. This has further being progressing slowly as the attrition rate increases. This study aims to apply the proposed models that incorporates several factors in predicting the number PhD students that will complete their PhD studies on time. Binary Logistic Regression model is proposed and used on the set of data to determine the number. The results show that only 6.8% of the 2014 PhD students are predicted to graduate on time and the results are compared wih the actual number for validation purpose.

  17. Interoperability in digital electrocardiography: harmonization of ISO/IEEE x73-PHD and SCP-ECG.

    Science.gov (United States)

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Serrano, Luis; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2010-11-01

    The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard for short-term diagnostic ECGs (EN1064:2005+A1:2007) has recently been approved as part of the x73 family (ISO 11073-91064:2009). These factors suggest the coordinated use of these two standards in foreseeable telecardiology environments, and hence the need to harmonize them. Such harmonization is the subject of this paper. Thus, a mapping of the mandatory attributes defined in the second draft of the ISO/IEEE 11073-10406-d02 and the minimum SCP-ECG fields is presented, and various other capabilities of the SCP-ECG Standard (such as the messaging part) are also analyzed from an x73-PHD point of view. As a result, this paper addresses and analyzes the implications of some inconsistencies in the coordinated use of these two standards. Finally, a proof-of-concept implementation of the draft x73-PHD ECG device specialization is presented, along with the conversion from x73-PHD to SCP-ECG. This paper, therefore, provides recommendations for future implementations of telecardiology systems that are compliant with both x73-PHD and SCP-ECG.

  18. Employability of genetic counselors with a PhD in genetic counseling.

    Science.gov (United States)

    Wallace, Jody P; Myers, Melanie F; Huether, Carl A; Bedard, Angela C; Warren, Nancy Steinberg

    2008-06-01

    The development of a PhD in genetic counseling has been discussed for more than 20 years, yet the perspectives of employers have not been assessed. The goal of this qualitative study was to gain an understanding of the employability of genetic counselors with a PhD in genetic counseling by conducting interviews with United States employers of genetic counselors. Study participants were categorized according to one of the following practice areas: academic, clinical, government, industry, laboratory, or research. All participants were responsible for hiring genetic counselors in their institutions. Of the 30 employers interviewed, 23 envisioned opportunities for individuals with a PhD degree in genetic counseling, particularly in academic and research settings. Performing research and having the ability to be a principal investigator on a grant was the primary role envisioned for these individuals by 22/30 participants. Employers expect individuals with a PhD in genetic counseling to perform different roles than MS genetic counselors with a master's degree. This study suggests there is an employment niche for individuals who have a PhD in genetic counseling that complements, and does not compete with, master's prepared genetic counselors.

  19. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    OpenAIRE

    Rie Raffing; Thor Bern Jensen; Hanne Tønnesen

    2017-01-01

    Background Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their...

  20. Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.

    Science.gov (United States)

    Rauner, Martina; Franke, Kristin; Murray, Marta; Singh, Rashim Pal; Hiram-Bab, Sahar; Platzbecker, Uwe; Gassmann, Max; Socolovsky, Merav; Neumann, Drorit; Gabet, Yankel; Chavakis, Triantafyllos; Hofbauer, Lorenz C; Wielockx, Ben

    2016-10-01

    The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing. Recent studies point toward a role for the PHD2-erythropoietin (EPO) axis in the modulation of bone remodeling, even though the studies produced conflicting results. Here, we used a number of mouse strains deficient of PHD2 in different cell types to address the role of PHD2 and its downstream targets HIF-1α and HIF-2α in bone remodeling. Mice deficient for PHD2 in several cell lineages, including EPO-producing cells, osteoblasts, and hematopoietic cells (CD68:cre-PHD2 f/f ) displayed a severe reduction of bone density at the distal femur as well as the vertebral body due to impaired bone formation but not bone resorption. Importantly, using osteoblast-specific (Osx:cre-PHD2 f/f ) and osteoclast-specific PHD2 knock-out mice (Vav:cre- PHD2 f/f ), we show that this effect is independent of the loss of PHD2 in osteoblast and osteoclasts. Using different in vivo and in vitro approaches, we show here that this bone phenotype, including the suppression of bone formation, is directly linked to the stabilization of the α-subunit of HIF-2, and possibly to the subsequent moderate induction of serum EPO, which directly influenced the differentiation and mineralization of osteoblast progenitors resulting in lower bone density. Taken together, our data identify the PHD2:HIF-2α:EPO axis as a so far unknown regulator of osteohematology by controlling bone homeostasis. Further, these data suggest that patients treated with PHD inhibitors or EPO should be monitored with respect to their bone status. © 2016 American Society for Bone and Mineral Research. © 2016 American Society for Bone and Mineral Research.

  1. The core competencies of James Marion Sims, MD.

    Science.gov (United States)

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  2. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  3. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  4. A Radar Multi-target Tracking Algorithm Based on Gaussian Mixture PHD Filter under Doppler Blind Zone

    Directory of Open Access Journals (Sweden)

    Wei Qiang

    2017-02-01

    Full Text Available Due to the Doppler Blind Zone (DBZ, the target tracking of Doppler radar becomes more and more complicated. In this paper, a multi-target tracking algorithm based on Gaussian Mixture Probability Hypothesis Density (GM-PHD for DBZ is proposed. The algorithm introduces the Minimum Detectable Velocity (MDV information to the traditional detection probability model to update the GM-PHD and the updated equation of the GM-PHD is deduced. The simulation results show that, compared to the traditional GM-PHD with the only Doppler measurement, the proposed algorithm improves greatly the radar tracking performance of moving target under the condition of minor MDV.

  5. Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

    Directory of Open Access Journals (Sweden)

    Jin Zhao

    2016-03-01

    Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

  6. MD 2485: Active halo control using narrowband and colored noise excitations

    CERN Document Server

    Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

  7. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, Noreddine

    2016-09-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  8. Do PhD supervisors play a role in bridging academic cultures?

    DEFF Research Database (Denmark)

    Elliot, Dely; Kobayashi, Sofie

    Our study reports a phenomenological investigation of ten international PhD students’ and nine supervisors’ first-hand experience of being in doctoral supervisory relationships in a Danish setting. In-depth qualitative data were gathered through face-to-face individual interviews, which explored......, we strongly argue that PhD supervisors also have a significant part to play in facilitating successful transition of their PhD students to a new academic culture. Literature in doctoral education recognises the importance of ‘pastoral care’ in the supervisory bond for nurturing students’ overall...... learning, e.g. confidence and capacity-building in preparation for independent research (Cotterall, 2013; Wright, 2003). Pastoral care arguably includes supervisors’ efforts to facilitate the transition to the new learning environment. Yet, more in-depth examination of this aspect of the supervisory...

  9. A model for supporting and training clinical pharmaceutical scientist PhD students.

    Science.gov (United States)

    Tortorici, Michael A; Skledar, Susan J; Zemaitis, Michael A; Weber, Robert J; Smith, Randall B; Kroboth, Patricia D; Poloyac, Samuel M

    2007-04-15

    To enhance the clinical training and financial support of graduate students in a Clinical Pharmaceutical Scientist PhD Program at the University of Pittsburgh School of Pharmacy. The School of Pharmacy and University of Pittsburgh Medical Center entered into a collaborative agreement to develop the Clinical Scientist Associate (CSA) program, as well as financially support students enrolled in a Pharmaceutical Sciences PhD program. These clinical training experiences are in addition to the didactic and laboratory experiences in the pharmaceutical sciences graduate program. Since 2002, three students have participated as CSAs, simultaneously working on their graduate research and meeting the requirements of the CSA program. The CSA program is a novel model for clinical training and support of post-PharmD graduate students enrolled in a PhD clinical pharmaceutical scientist program.

  10. Cooperative Localization for Multi-AUVs Based on GM-PHD Filters and Information Entropy Theory

    Directory of Open Access Journals (Sweden)

    Lichuan Zhang

    2017-10-01

    Full Text Available Cooperative localization (CL is considered a promising method for underwater localization with respect to multiple autonomous underwater vehicles (multi-AUVs. In this paper, we proposed a CL algorithm based on information entropy theory and the probability hypothesis density (PHD filter, aiming to enhance the global localization accuracy of the follower. In the proposed framework, the follower carries lower cost navigation systems, whereas the leaders carry better ones. Meanwhile, the leaders acquire the followers’ observations, including both measurements and clutter. Then, the PHD filters are utilized on the leaders and the results are communicated to the followers. The followers then perform weighted summation based on all received messages and obtain a final positioning result. Based on the information entropy theory and the PHD filter, the follower is able to acquire a precise knowledge of its position.

  11. Twelve tips for choosing and surviving a PhD in medical education - a student perspective.

    Science.gov (United States)

    Bryan, Billy; Church, Helen R

    2017-11-01

    The decision to undertake a PhD in medical education could mark a critical point in defining your future career. Attaining the highest level of degree in such a diverse and rewarding area as medical education may not only provide you with an opportunity to undertake important new research, but could also unlock different job opportunities. As is often the case, such rewards are not gained lightly. There can be real challenges in making the decision to undertake and then to successfully navigate a PhD. The specific subject and process of each doctorate is unique, leaving many prospective and current students uncertain as to what to expect. We offer our twelve tips from the perspective of two current PhD students to help guide those who share our interest in medical education and are considering doctoral study.

  12. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  13. Cooperative Localization for Multi-AUVs Based on GM-PHD Filters and Information Entropy Theory.

    Science.gov (United States)

    Zhang, Lichuan; Wang, Tonghao; Zhang, Feihu; Xu, Demin

    2017-10-08

    Cooperative localization (CL) is considered a promising method for underwater localization with respect to multiple autonomous underwater vehicles (multi-AUVs). In this paper, we proposed a CL algorithm based on information entropy theory and the probability hypothesis density (PHD) filter, aiming to enhance the global localization accuracy of the follower. In the proposed framework, the follower carries lower cost navigation systems, whereas the leaders carry better ones. Meanwhile, the leaders acquire the followers' observations, including both measurements and clutter. Then, the PHD filters are utilized on the leaders and the results are communicated to the followers. The followers then perform weighted summation based on all received messages and obtain a final positioning result. Based on the information entropy theory and the PHD filter, the follower is able to acquire a precise knowledge of its position.

  14. Low immediate scientific yield of the PhD among medical doctors

    DEFF Research Database (Denmark)

    Fosbol, Emil L.; Fosbøl, Philip Loldrup; Rerup, Sofie

    2016-01-01

    Background: We studied the scientific yield of the medical PhD program at all Danish Universities.Methods: We undertook a retrospective observational study. Three PhD schools in Denmark were included in order to evaluate the postdoctoral research production over more than 18 years through......: The scientific production of Danish medic PhD-graduates was mainly produced around the time of PhD-graduation. After obtaining the PhD-degree the scientific production declines suggesting that scientific advance fails and resources are not harnessed........ Scientific activity over time was assessed independently of author-rank and inactivity was measured relative to the date of graduation. Factors associated with inactivity were identified using multivariable logistic regression. 88.6 % of the PhD theses were conducted in internal medicine vs. 11...

  15. Nurses in the clinical area: relevance of a PhD.

    Science.gov (United States)

    Wilkes, Lesley M; Mohan, Shantala

    2008-01-01

    This project aimed to explore the application and relevance of a PhD to nurses working in the clinical area. The complexity of nursing practice requires clinical nurses to be competent as investigators and professional leaders who could help structure nursing practice in more efficient ways. Research proposes that a PhD offers Limited employment opportunities, is mainly research oriented and tends to direct a nurse away from the clinical field. A mixed method study design utilising surveys and interviews was chosen to collect data for this study. Participants were nurses with a doctoral degree working/having worked in a clinical area after obtaining their PhD Nurses were recruited through student databases from Australian universities that offer doctoral degrees in nursing and also by using a snowball sampling technique. The majority of the 19 nurses who participated in the study had: varied expectation of doing a PhD; maintained their clinical positions after obtaining their doctoral degree, considered that the degree helped them to obtain better jobs/promotions and acknowledged the value of the PhD in patient care, in improving research and informing health policy. This study has exposed the positive aspects of completing a PhD and identifies its constructive application in the clinical area. It is essential to provide support and opportunities for nurses working in the clinical area to pursue doctoral degrees in order to enable them to enhance knowledge and build confidence and leadership skills and contribute to the improvement of nursing practice and the continued development of the profession.

  16. Science PhD career preferences: levels, changes, and advisor encouragement.

    Science.gov (United States)

    Sauermann, Henry; Roach, Michael

    2012-01-01

    Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  17. Science PhD career preferences: levels, changes, and advisor encouragement.

    Directory of Open Access Journals (Sweden)

    Henry Sauermann

    Full Text Available Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  18. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT... restricted areas R-4002, Bloodsworth Island, MD; and R-4005, R-4006 and R-4007, Patuxent River, MD to ``U.S... areas R-4002, R-4005, R-4006 and R-4007 in Maryland, in order to reflect the correct organization...

  19. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    1997-01-01

    It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving...... the communication and cooperation between them. In a year of the PhDOOS network the workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information on the PhDOOS network can be found at http://purl.org/net/PhDOOS....

  20. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twenty...... engineering profilies:(1) Engineeing Design and Product Development and (2)Control Engineering which give possibilitie for specialisation in fluid power and mechatronics design and productdevelopment. Synthesis, design and self-learning competency have a high priority taking the importance of training...

  1. Metabolic engineering of apple by overexpression of the MdMyb10 gene

    Directory of Open Access Journals (Sweden)

    Khaled A.L. Rihani

    2017-06-01

    In the present study, the flavonoid pathway was successfully modified in apple by overexpressing the MdMyb10 transcription factor to validate the hypothesis of increased effect on plant disease resistance.

  2. 78 FR 62678 - Morris W. Cochran, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... conference with the parties, that he had intended to write May 17, 2013, rather than May 17, 2012, in the... plenary, administrative hearing. See Larry Elbert Perry, M.D., 77 FR 67,671 (DEA 2012); Treasure Coast...

  3. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  4. 77 FR 39630 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-07-05

    ... Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... and National Harbor Access Channel during the event. DATES: This rule is effective on July 8, 2012... ``Special Local Regulations for [[Page 39631

  5. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells.

    Directory of Open Access Journals (Sweden)

    Heidi Högel

    Full Text Available Hypoxia restricts cell proliferation and cell cycle progression at the G1/S interface but at least a subpopulation of carcinoma cells can escape the restriction. In carcinoma hypoxia may in fact select for cells with enhanced hypoxic survival and increased aggressiveness. The cellular oxygen sensors HIF proline hydroxylases (PHDs adapt the cellular functions to lowered environmental oxygen tension. PHD3 isoform has shown the strongest hypoxic upregulation among the family members. We detected a strong PHD3 mRNA expression in tumors of head and neck squamous cell carcinoma (HNSCC. The PHD3 expression associated with expression of hypoxic marker gene. Using siRNA in cell lines derived from HNSCC we show that specific inhibition of PHD3 expression in carcinoma cells caused reduced cell survival in hypoxia. The loss of PHD3, but not that of PHD2, led to marked cell number reduction. Although caspase-3 was activated at early hypoxia no induction of apoptosis was detected. However, hypoxic PHD3 inhibition caused a block in cell cycle progression. Cell population in G1 phase was increased and the population in S phase reduced demonstrating a block in G1 to S transition under PHD3 inhibition. In line with this, the level of hyperphosphorylated retinoblastoma protein Rb was reduced by PHD3 knock-down in hypoxia. PHD3 loss led to increase in cyclin-dependent kinase inhibitor p27 expression but not that of p21 or p16. The data demonstrated that increased PHD3 expression under hypoxia enhances cell cycle progression and survival of carcinoma cells.

  6. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  7. Image fusion in craniofacial virtual reality modeling based on CT and 3dMD photogrammetry.

    Science.gov (United States)

    Xin, Pengfei; Yu, Hongbo; Cheng, Huanchong; Shen, Shunyao; Shen, Steve G F

    2013-09-01

    The aim of this study was to demonstrate the feasibility of building a craniofacial virtual reality model by image fusion of 3-dimensional (3D) CT models and 3 dMD stereophotogrammetric facial surface. A CT scan and stereophotography were performed. The 3D CT models were reconstructed by Materialise Mimics software, and the stereophotogrammetric facial surface was reconstructed by 3 dMD patient software. All 3D CT models were exported as Stereo Lithography file format, and the 3 dMD model was exported as Virtual Reality Modeling Language file format. Image registration and fusion were performed in Mimics software. Genetic algorithm was used for precise image fusion alignment with minimum error. The 3D CT models and the 3 dMD stereophotogrammetric facial surface were finally merged into a single file and displayed using Deep Exploration software. Errors between the CT soft tissue model and 3 dMD facial surface were also analyzed. Virtual model based on CT-3 dMD image fusion clearly showed the photorealistic face and bone structures. Image registration errors in virtual face are mainly located in bilateral cheeks and eyeballs, and the errors are more than 1.5 mm. However, the image fusion of whole point cloud sets of CT and 3 dMD is acceptable with a minimum error that is less than 1 mm. The ease of use and high reliability of CT-3 dMD image fusion allows the 3D virtual head to be an accurate, realistic, and widespread tool, and has a great benefit to virtual face model.

  8. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Directory of Open Access Journals (Sweden)

    Gardie B

    2014-07-01

    of EPO transcription. The α subunits of the hypoxia-inducible transcription factor are hydroxylated by three prolyl hydroxylase domain (PHD enzymes, which belong to the iron and 2-oxoglutarate-dependent oxygenase superfamily. Sequence analysis of the genes encoding the PHDs in patients with erythrocytosis has revealed heterozygous germline mutations only occurring in Egl nine homolog 1 (EGLN1, also known as PHD2, the gene that encodes PHD2. To date, 24 different EGLN1 mutations comprising missense, frameshift, and nonsense mutations have been described. The phenotypes associated with the patients carrying these mutations are fairly homogeneous and typically limited to erythrocytosis with normal to elevated EPO. However, exceptions exist; for example, there is one case with development of concurrent paraganglioma (PHD2-H374R. Analysis of the erythrocytosis-associated PHD2 missense mutations has shown heterogeneous results. Structural studies reveal that mutations can affect different domains of PHD2. Some are close to the hypoxia-inducible transcription factor α/2-oxoglutarate or the iron binding sites for PHD2. In silico studies demonstrate that the mutations do not always affect fully conserved residues. In vitro and in cellulo studies showed varying effects of the mutations, ranging from mild effects to severe loss of function. The exact mechanism of a potential tumor-suppressor role for PHD2 still needs to be elucidated. A knockin mouse model expressing the first reported PHD2-P317R mutation recapitulates the phenotype observed in humans (erythrocytosis with inappropriately normal serum EPO levels and demonstrates that haploinsufficiency and partial deregulation of PHD2 is sufficient to cause erythrocytosis. Keywords: PHD2, EGLN1, HIF, hypoxia, erythropoietin, erythrocytosis

  9. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    Science.gov (United States)

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities.

    Science.gov (United States)

    Lapointe, Jason F; Dunphy, Gary B; Giannoulis, Paschalis; Mandato, Craig A; Nardi, James B; Gharib, Osama H; Niven, Donald F

    2011-11-01

    The innate non-self response systems of the deciduous tree pest, the forest tent caterpillar, Malacosoma disstria has been documented by us in terms of in vitro and in vivo reactions towards the Gram-positive nonpathogenic bacterium, Bacillus subtilis and Gram-negative pathogenic microbe, Xenorhabdus nematophila and their respective surface antigens, lipopoteichoic acids (LTA) and lipopolysaccharides (LPS). These studies, often conducted in whole and diluted hemolymph, preclude examination of plasma-free cellular (hemocyte) responses. Plasma-free hemocytes as primary cultures are difficult to obtain. The floating cell line Md66 and attached cell line Md108 from M. disstria hemocytes were examined as a model for plasma-free M. disstria hemocyte non-self responses. Herein, it was established that although both lines differed from each other and from the primary hemocyte cultures of M. disstria in growth parameters, cell composition and sizes both cell lines displayed granular cell-like (GL) cells and plasmatocyte-like (PL) cells according to morphological criteria and to some extent antigenic similarities based on labeling with anti-Chrysodeixis includens hemocyte monoclonal antibodies. Hemocyte-specific neuroglian-like protein was detected on cells of both cell lines and in the primary hemocyte cultures albeit with staining patterns differing according to culture and cell types, confluency levels and cell-cell adhesion. Both cell lines bound B. subtilis and X. nematophila, the reaction extent varying with the cell line and its cell types. LPS damaged both cell types in the two cell lines whereas LTA enhanced the adhesion of Md66 GL cells to flask surfaces followed by PL cell adhesion. PL cells of both lines, like the primary cultures, phagocytosed FITC-labeled B. subtilis; only Md108 GL cells phagocytosed B. subtilis. In either case phagocytosis was always less in frequency and intensity than the primary cultures. Proteins released from the cell lines differed in

  11. MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-01-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

  12. The Benefits of Publishing Systematic Quantitative Literature Reviews for PhD Candidates and Other Early-Career Researchers

    Science.gov (United States)

    Pickering, Catherine; Byrne, Jason

    2014-01-01

    Universities increasingly expect students to publish during a PhD candidature because it benefits the candidate, supervisor, institution, and wider community. Here, we describe a method successfully used by early-career researchers including PhD candidates to undertake and publish literature reviews--a challenge for researchers new to a field. Our…

  13. PhD Crisis Discourse: A Critical Approach to the Framing of the Problem and Some Australian "Solutions"

    Science.gov (United States)

    Cuthbert, Denise; Molla, Tebeje

    2015-01-01

    A feature of HE reform discourse is the tendency to construct the rationale for reform in terms of averting calamity and risk. We refer to this risk talk as "crisis discourse." This study examines the formulation of PhD crisis discourse internationally and in Australia. We find that a key feature of PhD crisis discourse is that…

  14. Who wants to enroll in health care PhD programs? An analysis of a nationwide graduate destination survey

    Directory of Open Access Journals (Sweden)

    Ying-Ju Pan

    2012-06-01

    Conclusion: These findings provide an overview of potential PhD students in the field of health care. Based on this assessment, effective strategies need to be developed to attract and retain qualified candidates, as well as other types of PhD students who are in demand in this field.

  15. Training of young researchers and PhD supervisors for the future

    DEFF Research Database (Denmark)

    Kolmos, Anette

    2004-01-01

    which contributes to break down the usual ways of thinking and to incorporate both intercultural and interdisciplinary principles, and a valued orientation towards trade and industry. The PhD supervisors should also be trained so that light is thrown on the aims, methods and contents of the supervision...

  16. Breaking the internet: making Stephen Hawking's PhD thesis available open access

    OpenAIRE

    Ammon, Matthias; Smith, Arthur

    2018-01-01

    Slides from a lightning talk (5 minute presentation) by Matthias Ammon (Research Support Librarian, MML Library, University of Cambridge) and Arthur Smith (Open Access Team, Office of Scholarly Communication, University of Cambridge). Presented at Cambridge Libraries Conference 2018. The talk discussed the process and impact of making Stephen Hawking's PhD thesis available as open access.

  17. Preparing Postbaccalaureates for Entry and Success in Biomedical PhD Programs

    Science.gov (United States)

    Hall, Joshua D.; Harrell, Jessica R.; Cohen, Kimberley W.; Miller, Virginia L.; Phelps, Patricia V.; Cook, Jeanette G.

    2016-01-01

    Certain racial and ethnic groups, individuals with disabilities, and those from low socioeconomic backgrounds remain underrepresented (UR) in the biomedical sciences. This underrepresentation becomes more extreme at each higher education stage. To support UR scholars during the critical transition from baccalaureate to PhD, we established an…

  18. and Gynaecology and G Sekaddc-Kigondu, PhD Associate ...

    African Journals Online (AJOL)

    2002-10-10

    Oct 10, 2002 ... and Gynaecology and G Sekaddc-Kigondu, PhD Associate Professor, Department of Clinical Chemistry, College of Health Sciences, University of Nairobi,. P.O Box 19676 ... participant and the simplicity and efficacy of the procedure, a large nurse filling out the questionnaire were blinded to allocation.

  19. Improving completion rates of students in biomedical PhD programs: an interventional study.

    Science.gov (United States)

    Viđak, Marin; Tokalić, Ružica; Marušić, Matko; Puljak, Livia; Sapunar, Damir

    2017-08-25

    Analysis of graduation success at the University of Split School of Medicine PhD programs conducted in 2011 revealed that only 11% of students who enrolled and completed their graduate coursework between 1999 and 2011 earned a doctoral degree. In this prospective cohort study we evaluated and compared three PhD programs within the same medical school, where the newest program, called Translational Research in Biomedicine (TRIBE), established in the academic year 2010/11, aimed to increase the graduation rate through an innovative approach. The intervention in the new program was related to three domains: redefined recruitment strategy, strict study regulations, and changes to the curriculum. We compared performance of PhD students between the new and existing programs and analyzed their current status, time to obtain a degree (from enrolment to doctorate), age at doctorate, number of publications on which the thesis was based and the impact factor of journals in which these were published. These improvement strategies were associated with higher thesis completion rate and reduced time to degree for students enrolled in the TRIBE program. There was no change in the impact factor or number of publications that were the basis for the doctoral theses. Our study describes good practices which proved useful in the design or reform of the PhD training program.

  20. Factors Influencing International PhD Students to Study Physics in Australia

    Science.gov (United States)

    Choi, Serene H.-J.; Nieminen, Timo A.; Townson, Peter

    2012-01-01

    Since physics research is an activity of an active international community, international visits are a common way for physicists to share scientific knowledge and skills. International mobility of physicists is also important for PhD physics study and research training. We investigated personal and social factors that influenced the decision for…

  1. Learning to Become Teacher Educators: Testimonies of Three PHD Students in China

    Science.gov (United States)

    Yuan, Rui

    2015-01-01

    While there has been an increasing number of graduate students who enter teacher education after obtaining a higher research degree (e.g., PhD or EdD), scant attention has been paid to their professional learning as prospective teacher educators in higher education. To fill this gap, this study, informed by the social theory of learning,…

  2. As others see us: what PhD students say about supervisors.

    Science.gov (United States)

    Yarwood-Ross, Lee; Haigh, Carol

    2014-09-01

    To explore the attitudes that doctoral students share with each other in an online postgraduate discussion forum. The supervisory role is pivotal to the successful completion of a PhD. Student satisfaction surveys are implemented by some universities, but there is currently no research that has investigated PhD students' experiences of supervision in the less formal environment of an online postgraduate discussion forum. Data were collected between September and December 2012 from the Postgraduate Forum, which receives posts from the global student community. The keywords used in the search were 'supervisor(s)' and 'supervision'. The data were analysed using thematic analysis. All relevant titles and posts from between January 2002 and the end of December 2012 were searched. The authors discovered five major themes: communication difficulties, control and engagement, academic bullying, lack of trust, and desertion. The relationship between students and supervisors is vital to successful PhD completion, and this study has provided some of the experiences students share with each other in an online postgraduate discussion forum. The online discussion forum provided an insight into students' perspectives of supervision but as it is asynchronous, there is limited analysis. Further research incorporating synchronous data collection methods would be helpful to examine students' experiences in greater detail. This study shows how an online postgraduate forum can be used as a source of data to gain an insight into PhD students' perspectives of supervision.

  3. Constructing an Institutional Identity in University Tea Rooms: The International PhD Student Experience

    Science.gov (United States)

    Fotovatian, Sepideh; Miller, Jenny

    2014-01-01

    This case study profiles eight international PhD students and describes the process of the construction and negotiation of their social and institutional identities in an Australian university. Audio-recorded informal conversations of the students highlight the role of social membership, staffroom interactions and language in the construction of…

  4. The Place of Theory: Locating the New Zealand "Education" Ph.D. Experience, 1948-1998

    Science.gov (United States)

    Middleton, Sue

    2007-01-01

    The year 1998 marked 50 years of doctoral study in New Zealand, and in 1999 I embarked on a history of Ph.D. theses in Education. Influenced by Foucaultian genealogy, this employed a fusion of bibliographic, archival and life-history interview methods. One hundred and eighty-three Education theses were identified and 57 of these graduates…

  5. A Dialogic about Using Facebook Status Updates for Education Research: A PhD Student's Journey

    Science.gov (United States)

    Barnes, Naomi; Penn-Edwards, Sorrel; Sim, Cheryl

    2015-01-01

    Facebook status updates provided the data for a study about the transition learning experiences of 1st-year university students. Strict ethical guidelines were proposed by the PhD researcher from the outset of the study. Anonymity was considered important for the approved ethical clearance for both the university and the participants.…

  6. Ensuring PhD development of responsible conduct of research behaviors: who's responsible?

    Science.gov (United States)

    Titus, Sandra L; Ballou, Janice M

    2014-03-01

    The importance of public confidence in scientific findings and trust in scientists cannot be overstated. Thus, it becomes critical for the scientific community to focus on enhancing the strategies used to educate future scientists on ethical research behaviors. What we are lacking is knowledge on how faculty members shape and develop ethical research standards with their students. We are presenting the results of a survey with 3,500 research faculty members. We believe this is the first report on how faculty work with and educate their PhD students on basic research standards. Specifically, we wanted to determine whether individual faculty members, who are advisors or mentors, differ in how they implemented components of responsible conduct of research (RCR) with their PhD students. Mentors were more likely than advisors or supervisors to report working with all of their PhDs, who graduated in the last 5 years, on the 17 recognized critical components of RCR training and research skill development. We also found about half of the faculty members believe RCR is an institutional responsibility versus a faculty responsibility. Less than a quarter have had opportunities to participate in faculty training to be a better mentor, advisor, or research teacher, and about one third of faculty did not or could not remember whether they had guidelines related to their responsibilities to PhD students. We discuss the implications of our findings and focus on ways that PhD research mentoring can be enhanced.

  7. What's in a Name? Comparing DPA and Ph.D. Programs.

    Science.gov (United States)

    Brewer, Gene A.; Facer, Rex L. II; O'Toole, Laurence J., Jr.; Douglas, James W.

    1999-01-01

    Compares graduate programs leading to either a DPA (Doctor of Public Administration) or a Ph.D., especially as regards research productivity. Finds few differences between the programs, noting that degree title is more informative about the type of students recruited than outputs (e.g., journal publications). Overall low research productivity by…

  8. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  9. Determinants of PhD Completion Time at the University of Ibadan ...

    African Journals Online (AJOL)

    The demand for Ph.D degree holders has increased in recent time because of their potential to stimulate national development and promote technological advancement. In view of the desire of the nation to be among the first 20 most developed nations by 2020 and meet the manpower requirement of teaching in the ...

  10. 9th Workshop for PhD Students in Object Oriented Systems

    NARCIS (Netherlands)

    Rashid, Awais; Parsons, David; Telea, Alexandru

    1999-01-01

    The PhDOOS workshop covered a wide scope, as its over 20 participants were PhD students in all areas of object orientation. The presentations covered topics such as databases, languages, software engineering and artificial intelligence, components and generative programming, analysis and design,

  11. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts…

  12. Black Engineering Students' Motivation for PhD Attainment: Passion Plus Purpose

    Science.gov (United States)

    McGee, Ebony O.; White, Devin T.; Jenkins, Akailah T.; Houston, Stacey; Bentley, Lydia C.; Smith, William J.; Robinson, William H.

    2016-01-01

    Purpose: Much of the extant research, practice and policy in engineering education has focused on the limited persistence, waning interest and lack of preparation among Black students to continue beyond the post-secondary engineering pipeline. However, this research suggests that many Black PhD students persist and succeed in engineering, fueled…

  13. Temporary Contracts: Effect on Job Satisfaction and Personal Lives of Recent Phd Graduates

    Science.gov (United States)

    Waaijer, Cathelijn J. F.; Belder, Rosalie; Sonneveld, Hans; van Bochove, Cornelis A.; van der Weijden, Inge C. M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market theory shows temporary employment to have a…

  14. Charles E. Land, Ph.D., acclaimed statistical expert on radiation risk assessment, died January 2018

    Science.gov (United States)

    Charles E. Land, Ph.D., an internationally acclaimed statistical expert on radiation risk assessment, died January 25, 2018. He retired in 2009 from the NCI Division of Cancer Epidemiology and Genetics. Dr. Land performed pioneering work in modern radiation dose-response analysis and modeling of low-dose cancer risk.

  15. Work organization and mental health problems in PhD students

    NARCIS (Netherlands)

    Levecque, K.; Anseel, F.; De Beuckelaer, A.; Van der Heyden, J.; Gisle, L.

    2017-01-01

    Research policy observers are increasingly concerned about the potential impact of current academic working conditions on mental health, particularly in PhD students. The aim of the current study is threefold. First, we assess the prevalence of mental health problems in a representative sample of

  16. Meet EPA Scientist Carolina Peñalva-Arana, Ph.D.

    Science.gov (United States)

    EPA scientist Carolina Peñalva-Arana, Ph.D., researches how to use molecular data to determine the health of an ecosystem. She and her colleagues are observing these tiny changes in ecosystem health to predict when an ecosystem is impaired earlier

  17. Measuring efficiency of university-industry Ph.D. projects using best worst method.

    Science.gov (United States)

    Salimi, Negin; Rezaei, Jafar

    2016-01-01

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what has been neglected is the other side of the coin-the inputs. The main aim of this study is to incorporate both the inputs and outputs of these projects into a more meaningful measure called efficiency. A ratio of the weighted sum of outputs over the weighted sum of inputs identifies the efficiency of a Ph.D. The weights of the inputs and outputs can be identified using a multi-criteria decision-making (MCDM) method. Data on inputs and outputs are collected from 51 Ph.D. candidates who graduated from Eindhoven University of Technology. The weights are identified using a new MCDM method called Best Worst Method (BWM). Because there may be differences in the opinion of Ph.D. candidates and supervisors on weighing the inputs and outputs, data for BWM are collected from both groups. It is interesting to see that there are differences in the level of efficiency from the two perspectives, because of the weight differences. Moreover, a comparison between the efficiency scores of these projects and their success scores reveals differences that may have significant implications. A sensitivity analysis divulges the most contributing inputs and outputs.

  18. Measuring efficiency of university-industry Ph.D. projects using best worst method

    NARCIS (Netherlands)

    Salimi, N.; Rezaei, J.

    2016-01-01

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what

  19. Temporary contracts : Effect on job satisfaction and personal lives of recent PhD graduates

    NARCIS (Netherlands)

    Waaijer, C.J.F.; Belder, R.; Sonneveld, H.; Van, Bochove C.A.; Van, der Weijden I.C.M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market

  20. Ability, academic climate, and going abroad for work or pursuing a PhD

    NARCIS (Netherlands)

    Bertrand - Cloodt, Danielle; Cörvers, Frank; Heijke, Hans

    We investigate whether highly able students are being creamed off from Dutch universities. Therefore, we examine the relation between ability and the destination of recent graduates of Dutch universities. Students can choose to continue their academic career by investing in a PhD degree instead of

  1. Ability, academic climate, and going abroad for work or pursuing a PhD

    NARCIS (Netherlands)

    Bertrand-Cloodt, D.A.M.; Cörvers, F.; Heijke, J.A.M.

    2014-01-01

    We investigate whether a creaming off of highly able students from Dutch universities is taking place. Therefore, we examine the relation between ability and the destination of recent graduates of Dutch universities. Students can choose to continue their academic career by investing in a PhD degree

  2. Learning to Write a Research Article: Ph.D. Students' Transitions toward Disciplinary Writing Regulation

    Science.gov (United States)

    Castello, Montserrat; Inesta, Anna; Corcelles, Mariona

    2013-01-01

    This paper presents a study designed from a socially situated and activity theory perspective aimed at gaining a deeper understanding of how Ph.D. students regulate their academic writing activity. Writing regulation is a complex activity of a highly situated and social nature, involving cyclical thought-action-emotion dynamics and the…

  3. At the MLA, a Ph.D. Candidate Navigates the Jobs Gantlet

    Science.gov (United States)

    Patton, Stacey

    2012-01-01

    It's the night before one of Javier Jimenez's big job interviews at the Modern Language Association (MLA) meeting. The 35-year-old graduate student, who is scheduled to earn his Ph.D. in comparative literature this spring from the University of California at Berkeley, is trying to ward off anxiety and abdominal pains. The mystique of the MLA, the…

  4. The first recipients of the ATLAS PhD Grant Scholarship Programme 2014

    CERN Multimedia

    Marcelloni, Claudia

    2014-01-01

    First recipients of the ATLAS PhD Grant Scholarship 2014 : With certificates, Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James PurvisProgramme: Lailin Xu, Josefina Alconada, and Gagik Vardanyan

  5. NOTES ON CONTRIBUTORS Millicent Quarcoo (BA, MPhil, PhD) is ...

    African Journals Online (AJOL)

    Admin

    He is currently a senior lecturer and Head of Department of Linguistics,. School of ... Augustina Pokua Owusu studied Linguistics and English at the University of Cape Coast, Ghana (BA). She is ... Uyilawa Usuanlele (PhD) is an associate professor at the Department of History, 443 Mahar Hall, State University of New.

  6. Is a PhD a necessary requirement for lecturers in a`Medical School ...

    African Journals Online (AJOL)

    Background: Makerere University introduced a new policy1 on the minimum qualification for appointment to a lecturer teaching position and eligibility for subsequent promotions. The highlight of the policy is a requirement for a PhD or equivalent as the minimum qualification necessary for appointment to a lecturer position ...

  7. PhD versus DSW: A Critique of Trends in Social Work Doctoral Education

    Science.gov (United States)

    Howard, Tyriesa

    2016-01-01

    Social work educators are in a phase of reintroducing the doctor of social work (DSW) degree and refining distinctions between PhD and DSW doctoral programs. This article examines how the two options have been prey to a noticeable "seesaw of precedence", resulting in a debatable history of social work's approach to doctoral education…

  8. Women Ph.D. Students in Engineering and a Nuanced Terrain: Avoiding and Revealing Gender

    Science.gov (United States)

    Erickson, Shelley K.

    2012-01-01

    Tensions regarding gender emerged from interviews conducted with 20 women Ph.D. students. This article does not focus explicitly on the reasons for women's continued underrepresentation in engineering. Rather the students' explanations for underrepresentation serve as a case study with which to analyze their gendered experiences. They avoid freely…

  9. Identification and characterization of small molecule inhibitors of a PHD finger§

    Science.gov (United States)

    Wagner, Elise K.; Nath, Nidhi; Flemming, Rod; Feltenberger, John B.; Denu, John M.

    2012-01-01

    A number of histone-binding domains are implicated in cancer through improper binding of chromatin. In a clinically reported case of acute myeloid leukemia (AML), a genetic fusion protein between nucleoporin 98 and the third plant homeodomain (PHD) finger of JARID1A drives an oncogenic transcriptional program that is dependent on histone binding by the PHD finger. By exploiting the requirement for chromatin binding in oncogenesis, therapeutics targeting histone readers may represent a new paradigm in drug development. In this study, we developed a novel small molecule screening strategy that utilizes HaloTag technology to identify several small molecules that disrupt binding of the JARID1A PHD finger to histone peptides. Small molecule inhibitors were validated biochemically through affinity pull downs, fluorescence polarization, and histone reader specificity studies. One compound was modified through medicinal chemistry to improve its potency while retaining histone reader selectivity. Molecular modeling and site-directed mutagenesis of JARID1A PHD3 provided insights into the biochemical basis of competitive inhibition. PMID:22994852

  10. Winning the PhD Game: Evocative Playing of Snakes and Ladders

    Science.gov (United States)

    Dickie, Carolyn

    2011-01-01

    The purpose of this paper is to describe a qualitative approach to developing an understanding of the lived experiences of PhD students. Rather than relying on textbook reports and theories about studying a higher degree by research, by allowing the students' voices to be heard, explicit and conscious research can be used to generate appropriate…

  11. Blessings Amina Akporhonor (P.hD), Prof Doris O. Bozimo ...

    African Journals Online (AJOL)

    PRESERVATION OF RECORDS IN UNIVERSITY LIBRARIES IN THE SOUTH- SOUTH ZONE OF NIGERIA. Blessings Amina Akporhonor (P.hD), Prof Doris O. Bozimo. Page 5 quality storage containers and good handling practices will help extent the life of records. The step available to protect and preserve records will vary ...

  12. The Jasmonate-Activated Transcription Factor MdMYC2 Regulates ETHYLENE RESPONSE FACTOR and Ethylene Biosynthetic Genes to Promote Ethylene Biosynthesis during Apple Fruit Ripening[OPEN

    Science.gov (United States)

    Xu, Yaxiu; Zhang, Lichao; Ji, Yinglin; Tan, Dongmei; Yuan, Hui

    2017-01-01

    The plant hormone ethylene is critical for ripening in climacteric fruits, including apple (Malus domestica). Jasmonate (JA) promotes ethylene biosynthesis in apple fruit, but the underlying molecular mechanism is unclear. Here, we found that JA-induced ethylene production in apple fruit is dependent on the expression of MdACS1, an ACC synthase gene involved in ethylene biosynthesis. The expression of MdMYC2, encoding a transcription factor involved in the JA signaling pathway, was enhanced by MeJA treatment in apple fruits, and MdMYC2 directly bound to the promoters of both MdACS1 and the ACC oxidase gene MdACO1 and enhanced their transcription. Furthermore, MdMYC2 bound to the promoter of MdERF3, encoding a transcription factor involved in the ethylene-signaling pathway, thereby activating MdACS1 transcription. We also found that MdMYC2 interacted with MdERF2, a suppressor of MdERF3 and MdACS1. This protein interaction prevented MdERF2 from interacting with MdERF3 and from binding to the MdACS1 promoter, leading to increased transcription of MdACS1. Collectively, these results indicate that JA promotes ethylene biosynthesis through the regulation of MdERFs and ethylene biosynthetic genes by MdMYC2. PMID:28550149

  13. The Jasmonate-Activated Transcription Factor MdMYC2 Regulates ETHYLENE RESPONSE FACTOR and Ethylene Biosynthetic Genes to Promote Ethylene Biosynthesis during Apple Fruit Ripening.

    Science.gov (United States)

    Li, Tong; Xu, Yaxiu; Zhang, Lichao; Ji, Yinglin; Tan, Dongmei; Yuan, Hui; Wang, Aide

    2017-06-01

    The plant hormone ethylene is critical for ripening in climacteric fruits, including apple (Malus domestica). Jasmonate (JA) promotes ethylene biosynthesis in apple fruit, but the underlying molecular mechanism is unclear. Here, we found that JA-induced ethylene production in apple fruit is dependent on the expression of MdACS1, an ACC synthase gene involved in ethylene biosynthesis. The expression of MdMYC2, encoding a transcription factor involved in the JA signaling pathway, was enhanced by MeJA treatment in apple fruits, and MdMYC2 directly bound to the promoters of both MdACS1 and the ACC oxidase gene MdACO1 and enhanced their transcription. Furthermore, MdMYC2 bound to the promoter of MdERF3, encoding a transcription factor involved in the ethylene-signaling pathway, thereby activating MdACS1 transcription. We also found that MdMYC2 interacted with MdERF2, a suppressor of MdERF3 and MdACS1 This protein interaction prevented MdERF2 from interacting with MdERF3 and from binding to the MdACS1 promoter, leading to increased transcription of MdACS1 Collectively, these results indicate that JA promotes ethylene biosynthesis through the regulation of MdERFs and ethylene biosynthetic genes by MdMYC2. © 2017 American Society of Plant Biologists. All rights reserved.

  14. Low immediate scientific yield of the PhD among medical doctors.

    Science.gov (United States)

    Fosbøl, Emil L; Fosbøl, Philip L; Rerup, Sofie; Østergaard, Lauge; Ahmed, Mohammed H; Butt, Jawad; Davidsen, Julie; Shanmuganathan, Nirusiya; Juul, Simon; Lewinter, Christian

    2016-07-24

    We studied the scientific yield of the medical PhD program at all Danish Universities. We undertook a retrospective observational study. Three PhD schools in Denmark were included in order to evaluate the postdoctoral research production over more than 18 years through individual publications accessed by PubMed. A total of 2686 PhD-graduates (1995-2013) with a medical background were included according to registries from all PhD schools in Denmark. They had a median age of 35 years (interquartile range (IQR), 32-38) and 53 % were women at the time of graduation. Scientific activity over time was assessed independently of author-rank and inactivity was measured relative to the date of graduation. Factors associated with inactivity were identified using multivariable logistic regression. 88.6 % of the PhD theses were conducted in internal medicine vs. 11.4 % in surgery. During follow-up (median 6.9 years, IQR 3.0-11.7), PubMed data searches identified that 87 (3.4 %) of the PhD graduates had no publication after they graduated from the PhD program, 40 % had 5 or less, and 90 % had 30 or less. The median number of publications per year after PhD graduation was 1.12 (IQR 0.61-1.99) papers per year. About 2/3 of the graduates became inactive after 1 year and approximately 21 % of the graduates remained active during the whole follow-up. Female gender was associated with inactivity: adjusted odds ratio 1.59 (95 % confidence interval 1.24-2.05). The scientific production of Danish medic PhD-graduates was mainly produced around the time of PhD-graduation. After obtaining the PhD-degree the scientific production declines suggesting that scientific advance fails and resources are not harnessed.

  15. Exploring challenges of the reproductive health PhD curriculum: A qualitative research

    Directory of Open Access Journals (Sweden)

    Sh Kohan

    2016-07-01

    Full Text Available Introduction: Enhancing the quality and dynamicity of higher education programs requires continuous evaluation of curriculums. Reproductive health PhD program was established in 2006 in Iran while recommending that its curriculum be evaluated by assessing graduates’ performance in workplace and surveying students, faculty members and managers. This study aimed to explore challenges of the curriculum of reproductive health PhD program. Methods: Employing a qualitative content analysis approach and using purposive and sometimes opportunistic sampling, experiences and viewpoints of 33 graduates and students of reproductive health PhD program, educational managers and reproductive health board members about the curriculum of reproductive health PhD program were collected through individual interviews and notes in 2014-15. Data were transcribed and important expressions were coded. Classification of similar codes led to preliminary categories. Five main categories were extracted by further classifications. Results: The five main categories included inadequacy of course topics and contents, challenges of student education, failure in realizing curriculum goals, long research period, and ambiguity in graduates’ professional status were appeared; each of these included various subcategories. Conclusion: Results showed that the curriculum of reproductive health PhD program required revisions to meet the program’s mission and designing courses such as sexual health and reinforcing the clinical nature of the program were necessary. Moreover, the results emphasized that the establishment of an independent educational department of reproductive health for managing higher education affairs and greater supervision of the reproductive health board on educational affairs was necessary. Furthermore, reproductive health specialists should be employed in different positions to meet society’s reproductive health needs.

  16. The evaluation of reproductive health PhD program in Iran: The input indicators analysis.

    Science.gov (United States)

    AbdiShahshahani, Mahshid; Ehsanpour, Soheila; Yamani, Nikoo; Kohan, Shahnaz

    2014-11-01

    Appropriate quality achievement of a PhD program requires frequent assessment and discovering the shortcomings in the program. Inputs, which are important elements of the curriculum, are frequently missed in evaluations. The purpose of this study was to evaluate the input indicators of reproductive health PhD program in Iran based on the Context, Input, Process, and Product (CIPP) evaluation model. This is a descriptive and evaluative study based on the CIPP evaluation model. It was conducted in 2013 in four Iranian schools of nursing and midwifery of medical sciences universities. Statistical population consisted of four groups: heads of departments (n = 5), faculty members (n = 18), graduates (n = 12), and PhD students of reproductive health (n = 54). Data collection tools were five separate questionnaires including 37 indicators that were developed by the researcher. Content and face validity were evaluated based on the experts' indications. The Cronbach's alpha coefficient was calculated in order to obtain the reliability of the questionnaires. Collected data were analyzed by SPSS software. Data were analyzed by descriptive statistics (mean, frequency, percentage, and standard deviation), and one-way analysis of variance (ANOVA) and least significant difference (LSD) post hoc tests to compare means between groups. The results of the study indicated that the highest percentage of the heads of departments (80%), graduates (66.7%), and students (68.5%) evaluated the status of input indicators of reproductive health PhD program as relatively appropriate, while most of the faculties (66.7%) evaluated that as appropriate. It is suggested to explore the reasons for relatively appropriate evaluation of input indicators by further academic researches and improve the reproductive health PhD program accordingly.

  17. Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

    Directory of Open Access Journals (Sweden)

    Nurvita Septya Ningrum

    2016-10-01

    Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

  18. The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

    Science.gov (United States)

    Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

    2017-05-01

    MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

  19. Chosen-Prefix Collisions for MD5 and Colliding X.509 Certificates for Different Identities

    Science.gov (United States)

    Stevens, Marc; Lenstra, Arjen; de Weger, Benne

    We present a novel, automated way to find differential paths for MD5. As an application we have shown how, at an approximate expected cost of 250 calls to the MD5 compression function, for any two chosen message prefixes P and P', suffixes S and S' can be constructed such that the concatenated values P||S and P'||S' collide under MD5. Although the practical attack potential of this construction of chosen-prefix collisions is limited, it is of greater concern than random collisions for MD5. To illustrate the practicality of our method, we constructed two MD5 based X.509 certificates with identical signatures but different public keys and different Distinguished Name fields, whereas our previous construction of colliding X.509 certificates required identical name fields. We speculate on other possibilities for abusing chosen-prefix collisions. More details than can be included here can be found on www.win.tue.nl/hashclash/ChosenPrefixCollisions/.

  20. The MD-MEd Joint-Degree Program at Vanderbilt University: Training Future Expert Medical Educators.

    Science.gov (United States)

    Sullivan, William M; DeVolder, Jacob; Bhutiani, Monica; Neal, Kristen W; Miller, Bonnie M

    2017-08-01

    Some medical students are drawn to medical education as an area of academic specialization. However, few options exist for medical students who wish to build a scholarly foundation for future careers in medical education. In 2011, Vanderbilt University School of Medicine (VUSM) and Peabody College of Education and Human Development at Vanderbilt University partnered to establish a novel dual-degree program that, through transfer of credit, allows students to graduate with both an MD and a master of education (MEd) degree in five years. The MD-MEd joint-degree program equips students with robust knowledge and skills related to general education while providing opportunities through independent studies and capstone projects to contextualize these ideas in medical education. This innovation at Vanderbilt University demonstrates the feasibility of an MD-MEd joint-degree program. MD-MEd graduates' demonstrated commitment to medical education and credentials will allow them to take on greater educational responsibilities earlier in their careers and quickly gain experience. The three author participants feel their experiences allowed them to achieve desired competencies as educators. They have each gained early experience by chairing the Student Curriculum Committee and contributing to major curricular reform at VUSM. The authors plan to integrate specific medical education competencies into the program, which will require MD-MEd students to develop and demonstrate proficiency in the knowledge and skills expected of dedicated medical educators. Graduates' career trajectories will be tracked to explore whether they become medical educators, conduct educational research, and assume leadership positions.

  1. Desain Aplikasi Algoritma MD5 (Message Digest 5 Pada Media SMS Berbasis Android Mobile

    Directory of Open Access Journals (Sweden)

    Zaiful Bahri

    2017-11-01

    Full Text Available AbstrakTulisan ini membahas tentang disain Aplikasi Algoritma MD5. Dalam desain ini dibuat model kirim dan terima SMS aman. Dari model ini bisa dibuat desain aplikasi berbasis objek menggunakan Unified Modeling Language (UML, State Machine untuk menggambarkan status pengiriman pesan dan Graphical User Interface (GUI yang user friendly menggunakan Android Studio 2.3.3 dan  gradle 3.3. Desain ini juga memerlukan sebuah database. Hasil desain ini dapat digunakan untuk membangun aplikasi mengirim dan menerima pesan aman secara umum dan khususnya aplikasi algoritma MD5 menggunakan Android. Kata kunci : Aplikasi, algoritma MD5, Android, SMS aman AbstractThis paper discusses the design of MD5 Algorithm application. In design is created a model to send and receive secured SMS. From this model is made an application design which is based on object using Unified Modeling Language (UML, State machine to give describing state of send and recive massage and Graphical User Interface (GUI which is user friendly using Android Studio 2.3.3 and Gradle 3.3. The application design also uses a database. The result of  design can be used to create an application to send and receive a secure message in general and especially message digest 5 algorithm using Android.  Keywords : Application, MD5 algorithm, Android, secure SMS

  2. Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey

    Science.gov (United States)

    Badyal, Dinesh K.; Daniel, Sujit R.

    2016-01-01

    Objectives: To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. Materials and Methods: An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. Results: There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. Conclusion: The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level. PMID:28031602

  3. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  4. Does working with industry come at a price? A study of doctoral candidates’ performance in collaborative vs. non-collaborative Ph.D. projects

    NARCIS (Netherlands)

    Salimi, Negin; Bekkers, Rudi; Frenken, Koen

    2015-01-01

    Collaborative Ph.D. projects between university and industry constitute an important aspect of university–industry collaboration, yet has remained under-researched thus far. The specific question this paper asks is how collaborative Ph.D. projects perform compared to non-collaborative Ph.D.

  5. AHA scientific statement: Summary of the scientific conference on dietary fatty acids and cardiovascular health

    NARCIS (Netherlands)

    Kris-Etherton, P.; Daniels, S.R.; Eckel, R.H.; Engler, M.; Howard, B.V.; Krauss, R.M.; Lichtenstein, A.H.; Sacks, F.; St. Jeor, S.; Stampfer, M.; Grundy, S.M.; Zock, P.L.

    2001-01-01

    Conference Planning and Writing Committee:Penny Kris-Etherton, PhD, Stephen R. Daniels, MD, PhD, Robert H. Eckel, MD, Marguerite Engler, PhD, RN, Barbara V. Howard, PhD, Ronald M. Krauss, MD, Alice H. Lichtenstein, DSc, Frank Sacks, MD, Sachiko St. Jeor, PhD, Meir Stampfer, MD, DrPH, For the

  6. MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

    CERN Document Server

    Fitterer, Miriam; Valishev, Alexander; Bruce, Roderik; Hofle, Wolfgang; Hostettler, Michi; Papadopoulou, Parthena Stefania; Papotti, Giulia; Papaphilippou, Yannis; Pellegrini, Dario; Trad, Georges; Valuch, Daniel; Valentino, Gianluca; Wagner, Joschka; Cai, Xu; CERN. Geneva. ATS Department

    2018-01-01

    For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015

  7. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark.

    Science.gov (United States)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-10-23

    Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors' self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. The Scientific Ethical Committee for the Capital Region of Denmark. Number: H-3-2010-101, date: 2010.09.29.

  8. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    Directory of Open Access Journals (Sweden)

    Rie Raffing

    2017-10-01

    Full Text Available Abstract Background Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors’ self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Results Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. Conclusions The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. Trial registration The Scientific Ethical Committee

  9. MD/MBA programs in the United States: evidence of a change in health care leadership.

    Science.gov (United States)

    Larson, David B; Chandler, Maria; Forman, Howard P

    2003-03-01

    Managerial sciences are playing an increasingly prominent role in the organization and delivery of health care. Despite popular media reports that a rising number of physicians are acquiring a background in this discipline through MD/MBA (medical and master of business administration) programs, no recent study has verified this. This study measured changes in the number and nature of the affiliations between management and medicine in the form of MD/MBA programs in the United States. Surveys of admission officers of 125 U.S. allopathic medical schools and of the overseers of each joint MD/MBA degree program were administered in May-October 2001. Main outcome measures included program growth, curriculum and degree requirements, application and admission requirements, and program leadership and organization. The number of MD/MBA programs grew from six to 33 between 1993 and 2001, and 17 more medical schools were considering establishing the joint-degree program. Ten, 15, and 20 programs produced 27, 42, and 61 graduates in 1999, 2000, and 2001, respectively, and over 100 students were expected to graduate per year when all 33 programs matured. Program structures and oversight indicate a spectrum of philosophies regarding the appropriate level of integration of the two degrees. MD/MBA programs apparently attempt to complement medical education with management education rather than the converse. The growth in the numbers of MD/MBA programs and participants indicates rising cooperation between medical and business schools and increasing interest in management education early in the careers of graduating physicians.

  10. The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

    Science.gov (United States)

    Dash, Madhumita; Malladi, Anish

    2012-06-25

    Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

  11. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  12. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  13. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  14. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Science.gov (United States)

    Laganapan, A. M. K.; Videcoq, A.; Bienia, M.; Ala-Nissila, T.; Bochicchio, D.; Ferrando, R.

    2015-04-01

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  15. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    Directory of Open Access Journals (Sweden)

    Xiaoli Wang

    2016-07-01

    Full Text Available Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZeneca for four years before joining Agilent Technologies in 2010. Recently, he won the prestigious 2016 Young Investigator Award from Chinese American Chromatography Association (CACA. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  16. Examining the British PhD viva: opening new doors or scarring for life?

    Science.gov (United States)

    Carter, Bernie; Whittaker, Karen

    2009-01-01

    The PhD viva -- regardless of its format -- has the potential to be a significant rite of passage for the student. It is an experience that can resonate for months or years afterwards. Part of the challenge is that for everyone involved -- student, supervisory team and examiners -- a degree of end-point uncertainty exists. These ambiguities and tensions are perhaps an inherent part of any examination but are particularly characteristic of the examination of the individual and unique body of work that constitutes the doctoral thesis. In recent years, increased attention has been placed on the processes that surround the examination, aiming to increase transparency, consistency and fairness. However, the process of examining a student and their thesis remains challenging and is surrounded by different agendas, ideologies and practices. This paper examines some of the issues surrounding the PhD viva, primarily focusing on the British viva whilst weaving in commentary about the Australian system.

  17. Publication ethics from the perspective of PhD students of health sciences: a limited experience.

    Science.gov (United States)

    Arda, Berna

    2012-06-01

    Publication ethics, an important subtopic of science ethics, deals with determination of the misconducts of science in performing research or in the dissemination of ideas, data and products. Science, the main features of which are secure, reliable and ethically obtained data, plays a major role in shaping the society. As long as science maintains its quality by being based on reliable and ethically obtained data, it will be possible to maintain its role in shaping the society. This article is devoted to the presentation of opinions of PhD candidate students in health sciences in Ankara concerning publication ethics. The data obtained from 143 PhD students from the fields of medicine, dentistry, pharmacy and veterinary reveal limited but unique experiences. It also shows that plagiarism is one of the worst issues in the publication ethics from the perspective of these young academics.

  18. Strategies for a successful PhD program: words of wisdom from the WJNR Editorial Board.

    Science.gov (United States)

    Conn, Vicki S; Zerwic, Julie; Rawl, Susan; Wyman, Jean F; Larson, Janet L; Anderson, Cindy M; Fahrenwald, Nancy L; Benefield, Lazelle E; Cohen, Marlene Z; Smith, Carol E; Topp, Robert; Markis, Natalie E

    2014-01-01

    Nursing doctoral programs prepare students for research-focused careers within academic settings. The purpose of this Editorial Board Special Article is to provide PhD students and advisors with suggestions for making the most of their doctoral experience. Editorial Board members provide their individual insights on the skills and attributes students must acquire during the course of their doctoral education in order to succeed. The authors provide practical tips and advice on how to excel in a PhD program, including how to select an advisor and a dissertation committee, the importance of attending conferences to increase visibility and develop a network of colleagues, presenting and publishing research while still a student, and balancing work and personal life. Students who take full advantage of the opportunities available to them during the course of their doctoral programs will graduate well prepared to take on the multiple responsibilities of research, teaching, and leadership.

  19. Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice.

    Science.gov (United States)

    Sasaki, Sumiyo; Nagai, Yoshinori; Yanagibashi, Tsutomu; Watanabe, Yasuharu; Ikutani, Masashi; Kariyone, Ai; Tsuneyama, Koichi; Hirai, Yoshikatsu; Takatsu, Kiyoshi

    2012-01-01

    MD-1 is a secreted protein that forms a complex with radioprotective 105 (RP105) and this complex plays a crucial role in lipopolysaccharide (LPS) recognition by B cells. Disease progression is known to improve in RP105-deficient lupus-prone MRL(lpr/lpr) mice. Furthermore, a soluble form of the homologous MD-2 protein is present in the plasma of septic patients and can opsonize gram-negative bacteria in cooperation with Toll-like receptor (TLR) 4. We have now established a flow cytometry-based assay to detect the soluble form of murine MD-1 (sMD-1) and explored potential roles in autoimmunity. The assay was quantitative and validated with sera from MD-1-deficient mice. Interestingly, heat-inactivated murine serum diminished the ability of sMD-1 to bind RP105. The sMD-1 was secreted by bone marrow-derived macrophages from C57BL/6 mice. Autoimmune prone MRL(lpr/lpr) mice had higher levels of sMD-1 than control MRL(+/+) mice, and levels markedly increased with disease progression. Expression of MD-1 but not MD-2 mRNA increased with age in the liver and kidney of MRL(lpr/lpr) mice. Finally, immunohistochemical analyses revealed that MD-1 was present in infiltrated macrophages within perivascular lesions of the MRL(lpr/lpr) kidney. This correlation suggests that sMD-1 may contribute to pathogenesis in this autoimmune disease model. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  1. Biomedical Science Ph.D. Career Interest Patterns by Race/Ethnicity and Gender.

    Science.gov (United States)

    Gibbs, Kenneth D; McGready, John; Bennett, Jessica C; Griffin, Kimberly

    2014-01-01

    Increasing biomedical workforce diversity remains a persistent challenge. Recent reports have shown that biomedical sciences (BMS) graduate students become less interested in faculty careers as training progresses; however, it is unclear whether or how the career preferences of women and underrepresented minority (URM) scientists change in manners distinct from their better-represented peers. We report results from a survey of 1500 recent American BMS Ph.D. graduates (including 276 URMs) that examined career preferences over the course of their graduate training experiences. On average, scientists from all social backgrounds showed significantly decreased interest in faculty careers at research universities, and significantly increased interest in non-research careers at Ph.D. completion relative to entry. However, group differences emerged in overall levels of interest (at Ph.D. entry and completion), and the magnitude of change in interest in these careers. Multiple logistic regression showed that when controlling for career pathway interest at Ph.D. entry, first-author publication rate, faculty support, research self-efficacy, and graduate training experiences, differences in career pathway interest between social identity groups persisted. All groups were less likely than men from well-represented (WR) racial/ethnic backgrounds to report high interest in faculty careers at research-intensive universities (URM men: OR 0.60, 95% CI: 0.36-0.98, p = 0.04; WR women: OR: 0.64, 95% CI: 0.47-0.89, p = 0.008; URM women: OR: 0.46, 95% CI: 0.30-0.71, pbiomedical workforce diversity challenges may limit the effectiveness of efforts to attract and retain the best and most diverse workforce. We propose incorporation of an ecological perspective of career development when considering strategies to enhance the biomedical workforce and professoriate through diversity.

  2. Including systematic reviews in PhD programmes and candidatures in nursing - 'Hobson's choice'?

    Science.gov (United States)

    Olsson, Cecilia; Ringnér, Anders; Borglin, Gunilla

    2014-03-01

    Nowadays, gathering and synthesising evidence, i.e. conducting systematic reviews, is considered an important part of any health service research endeavour. Reviewing the literature, however suggest that it is not yet common that PhD students/doctoral candidates publish systematic reviews or even include a high quality review of the literature as a part of their PhD programme or candidature. Implying that systematic reviewing skills might not be acquired by going through an education on a postgraduate level. Additionally, scholars debating systematic reviews 'to be or not to be' as a part of research training seem to be sparse, especially within the field of nursing. In this issue for debate, we would like to propose that the absence of systematic reviews' in this context might severely hamper the 'up and coming' researchers as well as the research conducted. We envisage that this lack can have a negative impact on international nursing practice, and therefore propose that systematic reviews should be considered, whenever appropriate, as a mandatory part of any PhD programme or candidature. We believe that abilities in systematic reviewing will be a sought after research skills in the near future. Including systematic reviews would promote i) refined, well-grounded adequate research questions, ii) PhDs with broad and elevated methodological skills, iii) an increased level of evidence based nursing praxis. However, to make this a reality, supervisors, PhD students, and candidates would need to understand the value of this kind of research activity. Finally, lobbying University faculty boards and grant providers that are not inclined to view literature reviews as 'proper' research or as an important part of health service research, needs to be put on the agenda. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  4. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

    OpenAIRE

    Baker, Lindsey A.; Allis, C. David; Wang, Gang G.

    2008-01-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved “reader/effector” modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialize...

  5. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.

    Science.gov (United States)

    Baker, Lindsey A; Allis, C David; Wang, Gang G

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved "reader/effector" modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized "reader" modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., "writers" and "erasers") are already known to be involved in various human diseases, mutations in the modification-specific "reader" proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies wherein "chromatin readers" stand as potential drug

  6. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  7. Fragment Molecular Orbital method-based Molecular Dynamics (FMO-MD) as a simulator for chemical reactions in explicit solvation.

    Science.gov (United States)

    Komeiji, Yuto; Ishikawa, Takeshi; Mochizuki, Yuji; Yamataka, Hiroshi; Nakano, Tatsuya

    2009-01-15

    Fragment Molecular Orbital based-Molecular Dynamics (FMO-MD, Komeiji et al., Chem Phys Lett 2003, 372, 342) is an ab initio MD method suitable for large molecular systems. Here, FMO-MD was implemented to conduct full quantum simulations of chemical reactions in explicit solvation. Several FMO-MD simulations were performed for a sphere of water to find a suitable simulation protocol. It was found that annealing of the initial configuration by a classical MD brought the subsequent FMO-MD trajectory to faster stabilization, and also that use of bond constraint in the FMO-MD heating stage effectively reduced the computation time. Then, the blue moon ensemble method (Sprik and Ciccotti, J Chem Phys 1998, 109, 7737) was implemented and was tested by calculating free energy profiles of the Menschutkin reaction (H3N + CH3Cl --> +H3NCH3 + Cl-) in the presence and absence of the solvent water via FMO-MD. The obtained free energy profiles were consistent with the Hammond postulate in that stabilization of the product by the solvent, namely hydration of Cl-, shifted the transition state to the reactant-side. Based on these FMO-MD results, plans for further improvement of the method are discussed. Copyright 2008 Wiley Periodicals, Inc.

  8. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

    Directory of Open Access Journals (Sweden)

    Adeline M Hajjar

    Full Text Available Although lipopolysaccharide (LPS stimulation through the Toll-like receptor (TLR-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

  9. Using Simulation in Nursing PhD Education: Facilitating Application of Responsible Conduct of Research Principles.

    Science.gov (United States)

    Clayton, Margaret F; Supiano, Katherine; Wilson, Rebecca; Lassche, Madeline; Latendresse, Gwen

    Simulation is a standard clinical nursing educational approach; however, simulation is rarely used in nonclinical nursing education. In doctor of philosophy (PhD) programs, ethical content about responsible conduct of research (RCR) is traditionally didactic, presented early in the program of study. Ethics content merits review before students begin the dissertation phase; thus, the purpose of this project was to design and implement simulated scenarios to help students apply RCR principles prior to beginning independent research. Two scenarios were developed: (a) a potential protocol change discussed in a research team meeting and (b) an in-home data collection experience with an elderly participant and her daughter. Actors were trained faculty volunteers, playing roles outside their usual academic positions. Faculty facilitated scenarios by posing questions as cues related to desired learning outcomes as scenarios unfolded. Eleven nursing PhD students and 6 faculty participated. Debriefing facilitated discussion of RCR principles, common research quandaries, and suggested scenario revisions. Faculty, expert observation, and video-review showed that younger and less experienced students tried to give the "right" answer rather than implement RCR appropriate solutions. Students with more clinical experience had difficulty adopting the less familiar researcher role. Overall, simulation is a novel and useful way to enhance RCR content in PhD programs. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  11. Advancing Minorities and Women to the PhD in Physics and Astronomy

    Science.gov (United States)

    Stassun, Keivan

    2017-01-01

    We briefly review the current status of underrepresented minorities in physics and astronomy: The underrepresentation of Black-, Hispanic-, and Native-Americans is an order of magnitude problem. We then describe the Fisk-Vanderbilt Masters-to-PhD Bridge program as a successful model for addressing this problem. Since 2004 the program has admitted 110 students, 90% of them underrepresented minorities (50% female), with a retention rate of 90%. The program has become the top producer of African American master's degrees in physics, and is now one of the top producers of minority PhDs in astronomy, materials science, and physics. We summarize the main features of the program including its core strategies: (1) replacing the GRE in admissions with indicators that are better predictive of long-term success, (2) partnering with a minority-serving institution for student training through collaborative research, and (3) using the master's degree as a deliberate stepping stone to the PhD. We show how misuse of the GRE in graduate admissions may by itself in large part explain the ongoing underrepresentation of minorities in PhD programs, and we describe our alternate methods to identify talented individuals most likely to succeed. We describe our mentoring model and toolkit which may be utilized to enhance the success of all PhD students.

  12. Pioneering women in American mathematics the pre-1940 PhD's

    CERN Document Server

    Green, Judy

    2008-01-01

    More than 14 percent of the PhD's awarded in the United States during the first four decades of the twentieth century went to women, a proportion not achieved again until the 1980s. This book is the result of a study in which the authors identified all of the American women who earned PhD's in mathematics before 1940, and collected extensive biographical and bibliographical information about each of them. By reconstructing as complete a picture as possible of this group of women, Green and LaDuke reveal insights into the larger scientific and cultural communities in which they lived and worked. The book contains an extended introductory essay, as well as biographical entries for each of the 228 women in the study. The authors examine family backgrounds, education, careers, and other professional activities. They show that there were many more women earning PhD's in mathematics before 1940 than is commonly thought. Extended biographies and bibliographical information are available from the companion website fo...

  13. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study.

  14. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  15. Forensic odontology education:from undergraduate to PhD - a Brazilian experience.

    Science.gov (United States)

    Dietrichkeit Pereira, J G; Frontanilla Recalde, T S; Barreto Costa, P; Jacometti, V; Vigorito Magalhães, L; Alves Da Silva, R H

    2017-12-01

    Forensic Odontology is a topic present in the majority of Dental Schools in Brazil, and due to this reality, some universities develop activities related to undergraduate and graduate students, from the Dentistry course until the Ph.D. degree. To present the education experience related to Forensic Odontology at School of Dentistry of Ribeirão Preto (USP - University of São Paulo), showing the strategies and activities in the different degrees (Dental course, Forensic Odontology Specialization Program, Specific Professional Training, Master, and Ph.D.). To the undergraduate students, many activities are developed in order to demonstrate all the possibilities that Forensic Dentistry allow, including theoretical and practical activities; in the Forensic Odontology Specialization Program, the dentists are trained to act as Forensic Odontologists in all its amplitude; in the Specific Professional Training, some courses are available, related to specific topics as DVI, Forensic Facial Reconstruction, Auditor in Dental Care Insurance and others; and in the Master and Ph.D. Programs, the professionals receive training in skills like teaching, research, student's guidance and others. In Brazil, Forensic Odontology is a well-known field in Dentistry and universities develop an important role in training a qualified workforce.

  16. MS PHD'S: A successful model for reaching underrepresented minorities (URM) students through virtual platforms

    Science.gov (United States)

    Scott, O.; Johnson, A.; Williamson, V.; Ricciardi, L.; Jearld, A., Jr.; Guzman, W. I.

    2014-12-01

    To successfully recruit and retain underrepresented minority (URM) students and early career scientists, many programs supplement traditional curricular activities with multiple online platforms, establishing "virtual communities" that are free and easily accessible. These virtual communities offer readily sustainable opportunities to facilitate communication across a wide range of cultural lines and socioeconomic levels thereby broadening participation and inclusivity in STEM. Established in 2003, the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Earth System Science Professional Development Program has successfully used virtual community tools such as a listserv, community forum, social media, and VoIP technologies, to extend the face-to-face activities of the program and support the advancement of URM students and early career scientists in STEM. The use of multiple facets of virtual community by MS PHD'S participants supports and encourages "real life" interactions and mentorship, facilitates networking and professional development, and maintains continuity of shared networks. The program is now in its ninth cohort and supports 213 participants. To date, 54 participants have completed their PhD and another 61 are currently enrolled in doctoral programs.

  17. A move-step analysis of the concluding chapters in computer science PhD theses

    Directory of Open Access Journals (Sweden)

    Carmen Soler-Monreal

    2016-11-01

    Full Text Available This paper describes how computer science doctoral writers construct the closing chapters of their PhD theses. The data are drawn from the chapters playing a concluding role of 48 PhD theses defended at the University of Glasgow from 2008 to 2014. The analysis applied a qualitative-quantitative approach. The titles of the concluding chapters of the theses were first examined and also their divisions into sections and sub-sections. Then the chapters were subjected to a move-step analysis: Move 1 (M1 “Revisiting the study”; Move 2 (M2 “Consolidating research space”; Move 3 (M3 “Proposing practical applications and implications”, Move 4 (M4 “Recommending future work” and Move 5 (M5 “Recapitulating the study”. The results revealed that most of the computer science PhD theses have one final concluding chapter with three main moves: M1, M2 and M4. The most frequent steps are “reviewing the work carried out” and “summarizing the specific work reported in every thesis chapter” in M1, “presenting results and contributions”, “answering the initial research questions or hypotheses”, and “making claims” in M2, and “acknowledging limitations” and “suggesting further research” in M4. Movestep patterns appear in recurrent cycles throughout the concluding chapters. Several suggestions for pedagogical purposes are provided.

  18. ISO/IEEE 11073 PHD message generation toolkit to standardize healthcare device.

    Science.gov (United States)

    Lim, Joon-Ho; Park, Chanyong; Park, Soo-Jun; Lee, Kyu-Chul

    2011-01-01

    As senior population increases, various healthcare devices and services are developed such as fall detection device, home hypertension management service, and etc. However, to vitalize healthcare devices and services market, standardization for interoperability between device and service must precede. To achieve the standardization goal, the IEEE 11073 Personal Health Device (PHD) group has been standardized many healthcare devices, but until now there are few devices compatible with the PHD standard. One of main reasons is that it isn't easy for device manufactures to implement standard communication module by analyzing standard documents of over 600 pages. In this paper, we propose a standard message generation toolkit to easily standardize existing non-standard healthcare devices. The proposed toolkit generates standard PHD messages using inputted device information, and the generated messages are adapted to the device with the standard state machine file. For the experiments, we develop a reference H/W, and test the proposed toolkit with three healthcare devices: blood pressure, weighting scale, and glucose meter. The proposed toolkit has an advantage that even if the user doesn't know the standard in detail, the user can easily standardize the non-standard healthcare devices.

  19. Research Career Persistence for Solar and Space Physics PhD

    Science.gov (United States)

    Moldwin, Mark B.; Morrow, Cherilynn

    2016-06-01

    Results from a recent graduate student survey found unsurprisingly that Solar and Space Physics (S&SP) PhD graduate students almost all aspire to have research careers in Solar and Space Physics. This study reports on the research career persistence over the first decade of the new millennium for S&SP PhDs. We used publication of science citation indexed articles as the indicator for persistence in a research career. We found that nearly two thirds (64%) of PhDs who graduated between 2001 and 2009 published refereed papers in 2012 or 2013, while 17% of PhDs never published another paper beyond the year they received their PhD. The remaining 19% of PhDs stopped publishing within three years of receiving their PhD. We found no gender difference between research persistence. We also found that though there is statistically no difference on persistence of publishing research between graduates of the largest programs compared to all other programs, there are significant differences between individual programs. This study indicates that a majority of S&SP PhDs find research careers but that a significant fraction pursue careers where publishing in science citation indexed journals is not required. Graduate programs, advisors, and potential graduate students can use these data for career planning and developing mentoring programs that meet the career outcomes of all of their graduates.

  20. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    DEFF Research Database (Denmark)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-01-01

    who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors' self-reported needs...... and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods: A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health......, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment...

  1. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A

    2015-01-01

    , ultimately, impaired CAF-mediated cancer cell invasion. Hypoxia inhibits prolyl hydroxylase domain protein 2 (PHD2), leading to hypoxia-inducible factor (HIF)-1α stabilisation, reduced expression of αSMA and periostin, and reduced myosin II activity. Loss of PHD2 in CAFs phenocopies the effects of hypoxia......, which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co......-injected with tumour cells similarly prevents CAF-induced metastasis to lungs and liver. Our data argue that reversion of CAFs towards a less active state is possible and could have important clinical implications....

  2. PhD students' experiences of thesis supervision in Malaysia: managing relationships in the midst of institutional change

    National Research Council Canada - National Science Library

    Krauss, Steven Eric; Ismail, Ismi Arif

    2010-01-01

    Despite the plethora of studies that have been conducted on PhD supervision, little qualitative investigation has been conducted with a diverse, non-Western sample of doctoral students in an attempt...

  3. Economic Analysis of Earning a PhD Degree After Completion of a PharmD Degree

    National Research Council Canada - National Science Library

    Nicholas E Hagemeier; Matthew M Murawski

    2011-01-01

    .... Income profiles were constructed based on 2008 annual salary data. NPV and IRR were calculated for careers resulting from the PhD degree and compared to those of the practicing community pharmacist...

  4. Economic analysis of earning a PhD degree after completion of a PharmD degree

    National Research Council Canada - National Science Library

    Hagemeier, Nicholas E; Murawski, Matthew M

    2011-01-01

    .... Income profiles were constructed based on 2008 annual salary data. NPV and IRR were calculated for careers resulting from the PhD degree and compared to those of the practicing community pharmacist...

  5. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  6. Property values, parks, and crime: a hedonic analysis in Baltimore, MD

    Science.gov (United States)

    Austin Troy; J. Morgan Grove

    2008-01-01

    While urban parks are generally considered to be a positive amenity, past research suggests that some parks are perceived as a neighborhood liability. Using hedonic analysis of property data in Baltimore, MD, we attempted to determine whether crime rate mediates how parks are valued by the housing market. Transacted price was regressed against park proximity, area-...

  7. Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications.

    Science.gov (United States)

    Margreitter, Christian; Petrov, Drazen; Zagrovic, Bojan

    2013-07-01

    Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete. Molecular dynamics (MD) simulations, which provide high-resolution insight into biomolecular function and underlying mechanisms, are in principle ideally suited to tackle this problem. However, because of the challenges associated with the development of novel MD parameters and a general lack of suitable computational tools for incorporating PTMs in target protein structures, MD simulations of post-translationally modified proteins have historically lagged significantly behind the studies of unmodified proteins. Here, we present Vienna-PTM web server (http://vienna-ptm.univie.ac.at), a platform for automated introduction of PTMs of choice to protein 3D structures (PDB files) in a user-friendly visual environment. With 256 different enzymatic and non-enzymatic PTMs available, the server performs geometrically realistic introduction of modifications at sites of interests, as well as subsequent energy minimization. Finally, the server makes available force field parameters and input files needed to run MD simulations of modified proteins within the framework of the widely used GROMOS 54A7 and 45A3 force fields and GROMACS simulation package.

  8. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  9. Data of evolutionary structure change: 1AHPA-2C4MD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AHPA-2C4MD 1AHP 2C4M A D SQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQ--PFAKP...1AHP A 1AHPA MLRAQ--PFAKP...1AHP A 1AHPA SLQKE-WANDL ...1AHP A 1AHPA LHSIG----KQGGD...1AHP A 1AHPA DVLYR-DQEAW

  10. MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data

    Directory of Open Access Journals (Sweden)

    Ng Raymond T

    2008-05-01

    Full Text Available Abstract Background Recent advances in global genomic profiling methodologies have enabled multi-dimensional characterization of biological systems. Complete analysis of these genomic profiles require an in depth look at parallel profiles of segmental DNA copy number status, DNA methylation state, single nucleotide polymorphisms, as well as gene expression profiles. Due to the differences in data types it is difficult to conduct parallel analysis of multiple datasets from diverse platforms. Results To address this issue, we have developed an integrative genomic analysis platform MD-SeeGH, a software tool that allows users to rapidly and directly analyze genomic datasets spanning multiple genomic experiments. With MD-SeeGH, users have the flexibility to easily update datasets in accordance with new genomic builds, make a quality assessment of data using the filtering features, and identify genetic alterations within single or across multiple experiments. Multiple sample analysis in MD-SeeGH allows users to compare profiles from many experiments alongside tracks containing detailed localized gene information, microRNA, CpG islands, and copy number variations. Conclusion MD-SeeGH is a new platform for the integrative analysis of diverse microarray data, facilitating multiple profile analyses and group comparisons.

  11. Molecular Dynamics Fingerprints (MDFP): Machine Learning from MD Data To Predict Free-Energy Differences.

    Science.gov (United States)

    Riniker, Sereina

    2017-04-24

    While the use of machine-learning (ML) techniques is well established in cheminformatics for the prediction of physicochemical properties and binding affinities, the training of ML models based on data from molecular dynamics (MD) simulations remains largely unexplored. Here, we present a fingerprint termed MDFP which is constructed from the distributions of properties such as potential-energy components, radius of gyration, and solvent-accessible surface area extracted from MD simulations. The corresponding fingerprint elements are the first two statistical moments of the distributions and the median. By considering not only the average but also the spread of the distribution in the fingerprint, some degree of entropic information is encoded. Short MD simulations of the molecules in water (and in vacuum) are used to generate MDFP. These are further combined with simple counts based on the 2D structure of the molecules into MDFP+. The resulting information-rich MDFP+ is used to train ML models for the prediction of solvation free energies in five different solvents (water, octanol, chloroform, hexadecane, and cyclohexane) as well as partition coefficients in octanol/water, hexadecane/water, and cyclohexane/water. The approach is easy to implement and computationally relatively inexpensive. Yet, it performs similarly well compared to more rigorous MD-based free-energy methods such as free-energy perturbation (FEP) as well as end-state methods such as linear interaction energy (LIE), the conductor-like screening model for realistic solvation (COSMO-RS), and the SMx family of solvation models.

  12. Short Chosen-Prefix Collisions for MD5 and the Creation of a Rogue CA Certificate

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A. Sotirov (Alexander); J. Appelbaum; A.K. Lenstra (Arjen); D. Molnar; D.A. Osvik; B. de Weger (Benne)

    2009-01-01

    textabstractWe present a refined chosen-prefix collision construction for MD5 that allowed creation of a rogue Certification Authority (CA) certificate, based on a collision with a regular end-user website certificate provided by a commercial CA. Compared to the previous construction from Eurocrypt

  13. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes establishing a temporary safety zone on the Atlantic Ocean in the vicinity of Ocean City, Maryland...

  14. 78 FR 60238 - Proposed Modification and Establishment of Restricted Areas; Aberdeen Proving Ground, MD

    Science.gov (United States)

    2013-10-01

    ...; Aberdeen Proving Ground, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., within the existing restricted areas R-4001A and R- 4001B, at the U.S. Army's Aberdeen Proving Ground in... nonparticipating aircraft from a hazard to navigation in the Aberdeen Proving Ground airspace. DATES: Comments must...

  15. 76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

    Science.gov (United States)

    2011-04-11

    ... merchandise and limited pre-packaged food and beverage. This action is necessary to avoid interruption of... National Park Service Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service, Interior. ACTION: Notice of proposed award of temporary concession...

  16. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD... temporary security zone encompassing certain waters of the Choptank River and Cambridge Channel in order to... will be held at the Hyatt Regency Chesapeake Bay Golf Resort, Spa and Marina in Cambridge, Maryland...

  17. 76 FR 16823 - Robert L. Dougherty, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-25

    ... Enforcement Administration Robert L. Dougherty, M.D.; Denial of Application On March 16, 2009, the Deputy... Order proposed the denial of Respondent's pending application for a DEA Certificate of Registration as a... Respondent's ``mis-judgments were well intentioned.'' Id. at 22-24. Next, the ALJ reasoned that ``there was...

  18. Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

    NARCIS (Netherlands)

    Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

    In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

  19. LaSalle D. Leffall, M.D., FACS and Leadership in American Surgery.

    Science.gov (United States)

    Britt, L D

    2017-12-12

    The term, Festschrift, is defined as a volume of learned articles or essays by colleagues and admirers, serving as a tribute to a scholar. The recognition of LaSalle D. Leffall, Jr., M.D., F.A.C.S. adds credence to the merits of such a tribute. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. 75 FR 24799 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD; Correction

    Science.gov (United States)

    2010-05-06

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations for Marine Events; Chester... information about the original regulation, contact Mr. Ronald Houck, Sector Baltimore Waterways Management... event to be held on the waters of the Chester River, Chestertown, MD on May 29, 2010. The special local...

  1. 77 FR 47279 - Special Local Regulations for Marine Events, Patuxent River; Solomons, MD

    Science.gov (United States)

    2012-08-08

    ... understanding this rule. If the rule would affect your small business, organization, or governmental... establishing special local regulations during the ``Chesapeake Challenge'' power boat races, a marine event to... Chesapeake Bay Power Boat Association will sponsor power boat races on the Patuxent River near Solomons, MD...

  2. A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland ...

    African Journals Online (AJOL)

    2002-01-01

    Jan 1, 2002 ... A. G. Hill, MBChB, MD, FRACS, Department of Surgery, Africa Inland Church Kijabe Hospital, P.O. Box 20, Kijabe, Kenya. MAJOR SALIVARY GLAND TUMOURS IN A RURAL KENYAN HOSPITAL. A. G. HILL. ABSTRACT. Background: Salivary gland tumours are not well characterised in Africa. The Kijabe.

  3. 78 FR 62666 - Kenneth Harold Bull, M.D.; Decision and Order

    Science.gov (United States)

    2013-10-22

    ... to 100 patients for opiate addiction with Suboxone and Subutex under the Drug Addiction Treatment Act... Show Cause to Kenneth Harold Bull, M.D. (Respondent), of Albuquerque, New Mexico. ALJ Ex. 1. The Show... because of actions taken by the New Mexico Medical Board, Respondent was without authority to handle...

  4. A mathematic model that describes modes of MdSGHV transmission within house fly populations

    Science.gov (United States)

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a h...

  5. 76 FR 16821 - Gregory F. Saric, M.D.; Decision and Order

    Science.gov (United States)

    2011-03-25

    ... similar to that of Respondent's.'' Exceptions at 1 (citing Stuart A. Bergman, M.D., 70 FR 33193 (2005)). Respondent notes that `` n Bergman , the ALJ delayed issuing her ruling on the Government's Motion for... under law to dispense a controlled substance.''). Thus, Respondent's reliance on Bergman is misplaced.\\2...

  6. 76 FR 70647 - Safety Zone; Fireworks Display, Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2011-11-15

    ... Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... floating platform located within the National Harbor Access Channel, in Prince Georges County, Maryland... Access Channel, within a 50 yards radius of a fireworks discharge platform in approximate position...

  7. 77 FR 20750 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-04-06

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... temporarily restrict vessel traffic in a portion of the Potomac River and National Harbor Access Channel... Access Channel from 6 a.m. to 10 a.m. The sponsor has stated that this marine event is not expected to be...

  8. 78 FR 20849 - Special Local Regulations; Marine Events, Potomac River; National Harbor Access Channel, MD

    Science.gov (United States)

    2013-04-08

    ...; National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY... Potomac River federal navigation channel and the National Harbor Access Channel. C. Discussion of Proposed... Harbor Access Channel and includes the waters of the Potomac River, from shoreline to shoreline, bounded...

  9. 77 FR 25106 - Special Local Regulations for Marine Events; Potomac River, National Harbor Access Channel, MD

    Science.gov (United States)

    2012-04-27

    ... River, National Harbor Access Channel, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... navigation channel and the National Harbor Access Channel. Due to the need for vessel control during the... through the regulated area, including the National Harbor Access Channel, will only be allowed to safely...

  10. 75 FR 12563 - Patuxent Research Refuge, Anne Arundel and Prince George's Counties, MD

    Science.gov (United States)

    2010-03-16

    ... Scarlet Tanager Loop, Laurel, MD 20708. FOR FURTHER INFORMATION CONTACT: Brad Knudsen, Refuge Manager... developing a CCP is to provide refuge managers with a 15-year plan for achieving refuge purposes and... team leader or project leader (see ADDRESSES). You may also send comments anytime during the planning...

  11. The draft genome of MD-2 pineapple using hybrid error correction of long reads.

    Science.gov (United States)

    Redwan, Raimi M; Saidin, Akzam; Kumar, S Vijay

    2016-07-03

    The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. © The Author 2016. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

  12. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  13. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Science.gov (United States)

    Irvine, Katherine L; Gangloff, Monique; Walsh, Catherine M; Spring, David R; Gay, Nicholas J; Bryant, Clare E

    2014-01-01

    The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4) are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS) antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA) within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly important in TLR

  14. Increasing PhD students’ employability by focusing on the academic entrepreneurship. The analysis of the entrepreneurial competences

    Directory of Open Access Journals (Sweden)

    Sabina Hodzic

    2016-05-01

    Full Text Available The aim of the present study was to explore the perspective for entrepreneurship among PhD students coming from variety of disciplines. More precisely, to identify the most important entrepreneurial competences for succeeding in the entrepreneurial venture, to explore whether these competences are being developed during the 3rd cycle studies, and to explore the entrepreneurial intentions of the future doctors. In order to choose the most important entrepreneurial competences, individual semi-structured interviews with ten entrepreneurs from different fields were conducted. In addition, the importance of each competence was evaluated in form of the questionnaire, by seventeen entrepreneurs. After the qualitative and quantitative analysis of the interviews and the questionnaire, 20 competences were selected as the most important entrepreneurial competences. These 20 competences were then evaluated by 50 PhD students from different fields of study. They evaluated the importance of each entrepreneurial competence, the level of its development during their PhD studies, and indicated their entrepreneurial intentions after finishing the PhD. The most important and the most developed competences are presented in the results. In addition, the results showed relatively high entrepreneurial intentions in case of not finding a job after the PhD and in general. These results imply the need for incorporating some sort of entrepreneurial training and the development of entrepreneurial competences adapted to each subject area during the PhD studies.

  15. Approaches to Climate Change & Health in Cuba: Guillermo Mesa MD MPhil, Director, Disasters & Health, National School of Public Health. Paulo Ortiz MS PhD, Senior Researcher, Climate Center, Cuban Meteorology Institute.

    Science.gov (United States)

    Mesa, Guillermo; Ortiz, Paulo; Gorry, Conner

    2015-04-01

    The US National Institutes of Health predict climate change will cause an additional 250,000 deaths between 2030 and 2050, with damages to health costing US$2-$4 billion by 2030. Although much debate still surrounds climate change, island ecosystems-such as Cuba's-in the developing world are arguably among the most vulnerable contexts in which to confront climate variability. Beginning in the 1990s, Cuba launched research to develop the evidence base, set policy priorities, and design mitigation and adaptation actions specifically to address climate change and its effects on health. Two researchers at the forefront of this interdisciplinary, intersectoral effort are epidemiologist Dr Guillermo Mesa, who directed design and implementation of the nationwide strategy for disaster risk reduction in the Cuban public health system as founding director of the Latin American Center for Disaster Medicine (CLAMED) and now heads the Disasters and Health department at the National School of Public Health; and Dr Paulo Ortiz, a biostatistician and economist at the Cuban Meteorology Institute's Climate Center (CENCLIM), who leads the research on Cuba's Climate and Health project and is advisor on climate change and health for the UN Economic Commission for Latin America and the Caribbean (ECLAC).

  16. 78 FR 72001 - Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Science.gov (United States)

    2013-12-02

    ... Class E Airspace; Salisbury, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action amends Class D and Class E airspace, and establishes Class E airspace at Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD, due to the decommissioning of the Salisbury VHF...

  17. 78 FR 52109 - Proposed Amendment of Class D and E Airspace, and Establishment of Class E Airspace; Salisbury, MD

    Science.gov (United States)

    2013-08-22

    ... Establishment of Class E Airspace; Salisbury, MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION..., and establish Class E airspace at Salisbury-Ocean City Wicomico Regional Airport, Salisbury, MD, due to the decommissioning of the Salisbury VHF Omnidirectional Radio Range Tactical Air Navigation Aid...

  18. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Science.gov (United States)

    2010-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin and...

  19. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lipopolysaccharide... by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysaccharide

  20. 33 CFR 334.160 - Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area.

    Science.gov (United States)

    2010-07-01

    ... Academy Santee Basin, Annapolis, Md.; naval restricted area. 334.160 Section 334.160 Navigation and... RESTRICTED AREA REGULATIONS § 334.160 Severn River, at U.S. Naval Academy Santee Basin, Annapolis, Md.; naval restricted area. (a) The area. The waters within the U.S. Naval Academy Santee Basin and adjacent waters of...

  1. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  2. RysannMD: A biomedical semantic annotator balancing speed and accuracy.

    Science.gov (United States)

    Cuzzola, John; Jovanović, Jelena; Bagheri, Ebrahim

    2017-07-01

    Recently, both researchers and practitioners have explored the possibility of semantically annotating large and continuously evolving collections of biomedical texts such as research papers, medical reports, and physician notes in order to enable their efficient and effective management and use in clinical practice or research laboratories. Such annotations can be automatically generated by biomedical semantic annotators - tools that are specifically designed for detecting and disambiguating biomedical concepts mentioned in text. The biomedical community has already presented several solid automated semantic annotators. However, the existing tools are either strong in their disambiguation capacity, i.e., the ability to identify the correct biomedical concept for a given piece of text among several candidate concepts, or they excel in their processing time, i.e., work very efficiently, but none of the semantic annotation tools reported in the literature has both of these qualities. In this paper, we present RysannMD (Ryerson Semantic Annotator for Medical Domain), a biomedical semantic annotation tool that strikes a balance between processing time and performance while disambiguating biomedical terms. In other words, RysannMD provides reasonable disambiguation performance when choosing the right sense for a biomedical term in a given context, and does that in a reasonable time. To examine how RysannMD stands with respect to the state of the art biomedical semantic annotators, we have conducted a series of experiments using standard benchmarking corpora, including both gold and silver standards, and four modern biomedical semantic annotators, namely cTAKES, MetaMap, NOBLE Coder, and Neji. The annotators were compared with respect to the quality of the produced annotations measured against gold and silver standards using precision, recall, and F1 measure and speed, i.e., processing time. In the experiments, RysannMD achieved the best median F1 measure across the

  3. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  4. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  5. Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2.

    Science.gov (United States)

    Oblak, Alja; Jerala, Roman

    2014-01-01

    The Toll-like receptor 4/MD-2 receptor complex recognizes endotoxin, a Gram-negative bacterial cell envelope component. Recognition of the most potent hexaacylated form of endotoxin is mediated by the sixth acyl chain that protrudes from the MD-2 hydrophobic pocket and bridges TLR4/MD-2 to the neighboring TLR4 ectodomain, driving receptor dimerization via hydrophobic interactions. In hypoacylated endotoxins all acyl chains could be accommodated within the binding pocket of the human hMD-2. Nevertheless, tetra- and pentaacylated endotoxins activate the TLR4/MD-2 receptor of several species. We observed that amino acid residues 82 and 122, located at the entrance to the endotoxin binding site of MD-2, have major influence on the species-specific endotoxin recognition. We show that substitution of hMD-2 residue V82 with an amino acid residue with a bulkier hydrophobic side chain enables activation of TLR4/MD-2 by pentaacylated and tetraacylated endotoxins. Interaction of the lipid A phosphate group with the amino acid residue 122 of MD-2 facilitates the appropriate positioning of the hypoacylated endotoxin. Moreover, mouse TLR4 contributes to the agonistic effect of pentaacylated msbB endotoxin. We propose a molecular model that explains how the molecular differences between the murine or equine MD-2, which both have sufficiently large hydrophobic pockets to accommodate all five or four acyl chains, influence the positioning of endotoxin so that one of the acyl chains remains outside the pocket and enables hydrophobic interactions with TLR4, leading to receptor activation.

  6. Employment Histories of Recent Astronomy Ph.D. Graduates from the University of Texas at Austin

    Science.gov (United States)

    Dinerstein, H.

    1996-12-01

    The University of Texas at Austin has one of the largest astronomy graduate programs in the U.S. As of several years ago, there were over 50 students enrolled, although the current number is closer to 35. During the decade 1980-89, a total of 85 students entered the program, of whom 64 (75%) completed the Ph.D. About a third (33%) of the Ph.D. graduates currently hold postdoctoral positions in astronomy. (Note that the sample includes some students who received their degrees within the last four or five years.) Another 35% hold permanent (or tenure-track) faculty jobs or positions at government laboratories or observatories in the U.S.; if one includes those who hold such positions in other countries, the total rises to 45%. (Some of these were foreign students who returned to their country of origin.) The remaining individuals are supported by grants (``soft money'') or are employed by companies doing work mostly unrelated to astronomy. Examination of the job histories and experiences of this cohort gives us crucial, realistic information on the present-day job market and prospects for professional success for new Ph.D.'s in astronomy. This is extremely important at a time when the American Astronomical Society and the profession at large is re-examining the effectiveness and goals of current graduate programs in astronomy. I report here results from a survey of this large cohort of recent graduates, including such information as the average number of postdocs held, and average number of years between receiving the Ph.D. and finding a permanent position in astronomy.

  7. The Ph.D. Process - A Student's Guide to Graduate School in the Sciences

    Science.gov (United States)

    Bloom, Dale F.; Karp, Jonathan D.; Cohen, Nicholas

    1999-02-01

    The Ph.D. Process offers the essential guidance that students in the biological and physical sciences need to get the most out of their years in graduate school. Drawing upon the insights of numerous current and former graduate students, this book presents a rich portrayal of the intellectual and emotional challenges inherent in becoming a scientist, and offers the informed, practical advice a "best friend" would give about each stage of the graduate school experience. What are the best strategies for applying to a graduate program? How are classes conducted? How should I choose an advisor and a research project? What steps can I take now to make myself more "employable" when I get my degree? What goes on at the oral defense? Through a balanced, thorough examination of issues ranging from lab etiquette to stress management, the authors--each a Ph.D. in the sciences--provide the vital information that will allow students to make informed decisions all along the way to the degree. Headlined sections within each chapter make it fast and easy to look up any subject, while dozens of quotes describing personal experiences in graduate programs from people in diverse scientific fields contribute invaluable real-life expertise. Special attention is also given to the needs of international students.Read in advance, this book prepares students for each step of the graduate school experience that awaits them. Read during the course of a graduate education, it serves as a handy reference covering virtually all major issues and decisions a doctoral candidate is likely to face. The Ph.D. Process is the one book every graduate student in the biological and physical sciences can use to stay a step ahead, from application all the way through graduation.

  8. Building the capacity to solve complex health challenges in sub-Saharan Africa: CARTA's multidisciplinary PhD training.

    Science.gov (United States)

    Fonn, Sharon; Egesah, Omar; Cole, Donald; Griffiths, Frances; Manderson, Lenore; Kabiru, Caroline; Ezeh, Alex; Thorogood, Margaret; Izugbara, Chimaraoke

    2016-12-27

    To develop a curriculum (Joint Advanced Seminars [JASs]) that produced PhD fellows who understood that health is an outcome of multiple determinants within complex environments and that approaches from a range of disciplines is required to address health and development within the Consortium for Advanced Research Training in Africa (CARTA). We sought to attract PhD fellows, supervisors and teaching faculty from a range of disciplines into the program. Multidisciplinary teams developed the JAS curriculum. CARTA PhD fellowships were open to academics in consortium member institutions, irrespective of primary discipline, interested in doing a PhD in public and population health. Supervisors and JAS faculty were recruited from CARTA institutions. We use routine JAS evaluation data (closed and open-ended questions) collected from PhD fellows at every JAS, a survey of one CARTA cohort, and an external evaluation of CARTA to assess the impact of the JAS curriculum on learning. We describe our pedagogic approach, arguing its centrality to an appreciation of multiple disciplines, and illustrate how it promotes working in multidisciplinary ways. CARTA has attracted PhD fellows, supervisors and JAS teaching faculty from across a range of disciplines. Evaluations indicate PhD fellows have a greater appreciation of how disciplines other than their own are important to understanding health and its determinants and an appreciation and capacity to employ mixed methods research. In the short term, we have been effective in promoting an understanding of multidisciplinarity, resulting in fellows using methods from beyond their discipline of origin. This curriculum has international application.

  9. Empirical Essays on the Labor Market Outcomes of PhD Graduates

    DEFF Research Database (Denmark)

    Pedersen, Heidi Skovgaard

    During the past decade, policy makers have accentuated the need for more PhDs to drive innovation and use their research skills to push the technological frontier. The public sector in Denmark has financially supported a doubling of the number of enrolled PhD students based on a strong belief...... and demand considerations. New evidence on how career decisions are formed based on early career trajectories may help in addressing the effects of the massive investments in training more PhDs. The dissertation is a first attempt to quantify how the growing numbers of PhDs affect their own employment...

  10. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    Directory of Open Access Journals (Sweden)

    Camelia Popa

    2013-03-01

    Full Text Available As a whole, this PhD thesis follows three research lines, namely: (1 the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2 the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3 the line of an awareness of the need to prevent and fight against the effects arising from money laundering processes, the national and international efforts taken until present nation- and worldwide and the future measures required to diminish the consequences of this scourge.

  11. The first Italian doctorate (PhD Course) in Physics Education Research

    Science.gov (United States)

    Michelini, Marisa; Santi, Lorenzo

    2008-05-01

    The first PhD Italian course in Physics Education Research in Udine aims to qualify young researchers and teachers coming from all the Italian groups of research in the field. It becomes a context for developing research projects carried out following parallel research lines on: Teaching/Learning paths for didactic innovation, cognitive research, ICT for strategies to overcome conceptual knots in physics; E-learning for personalization; d) Computer on-line experiments and modelling; e) Teacher formation and training; f) Informal learning in science.

  12. Development of an academic identity through PhD supervision-an issue for debate.

    Science.gov (United States)

    Murphy, Neil A; Wibberley, Christopher

    2017-01-01

    This paper provides reflection on the journey of completing a PhD by using emergent themes that occurred in supervision sessions as recorded in a reflective journal. The paper highlights the need to reflect and accept decisions that can be challenging. The paper also indicates examples where past understandings are questioned and newer insights have to be explored. A conclusion related to accepting responsibility for what happens as a consequence of supervision sessions is debated. Finally a new insight into identity is arrived at. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Where do new Ph.D. economists go? Evidence from recent initial job placements

    OpenAIRE

    Chen, Jihui; Liu, Qihong; Billger, Sherrilyn M.

    2012-01-01

    We use data from the 2007-2008 Ph.D. economist job market to investigate initial job placement in terms of job location, job type, and job rank. Our results suggest gender differences in all three dimensions of job placement. Relative to their male counterparts, female candidates are less (more) likely to be placed into academic (government or private sector) jobs and, on average, are placed into worse ranked jobs. Foreign female candidates are also more likely than foreign males to stay in t...

  14. Twenty of China's best physics PhD students visited CERN

    CERN Multimedia

    2006-01-01

    Twenty of the top physics PhD students in China were honoured with the 'E=mc2 to modern science' Einstein Award and received a three week tour of major laboratories in Germany and Switzerland, including CERN, DESY and the Max Planck Institute. The Einstein Award is co-sponsored by the German and Swiss Embassies in celebration of the 'Year of Physics' in 2005. For many years, Germany, Switzerland and China have been involved in numerous areas of scientific research and cooperation.

  15. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

    2015-04-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  16. MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

    CERN Document Server

    Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

    2017-01-01

    During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

  17. LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

    CERN Document Server

    AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

    2017-01-01

    The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

  18. MD-CTS: An integrated terminology reference of clinical and translational medicine

    Directory of Open Access Journals (Sweden)

    Will Ray

    2016-01-01

    Full Text Available New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS. It is the first public resource that comprehensively integrates Wiktionary (word definition, BioPortal (ontology, Wiki (image reference, and Medline abstract (word usage information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95% than paper-based dictionaries (57–71%.

  19. Towards the Structural Characterization of Intrinsically Disordered Proteins by SAXS and MD Simulation

    Science.gov (United States)

    Oroguchi, Tomotaka; Ikeguchi, Mitsunori; Sato, Mamoru

    2011-01-01

    Dynamical structures of intrinsically disordered proteins (IDPs) and multi-domain proteins that include large ID regions between the domains are unable to be determined by such conventional methods as X-ray crystallography and electron microscopy. Small-angle X-ray scattering (SAXS) is suitable to determine low-resolution structures of proteins and protein complexes in solution, but the structural data on protein dynamics are averaged over the structural ensemble in protein solution. To overcome this problem, we have developed a novel method, named MD-SAXS, of the combined use of SAXS and molecular dynamics (MD) simulation to analyze protein dynamics in solution of multi-subunit protein complexes and multi-domain proteins toward the structural characterization of IDPs. Here we show validity of the method through the structural characterization of restriction Endonuclease EcoO109I.

  20. Molecular Dynamics (MD) Simulation of DNA Dodecamer with 5-hydroxy-6-cytosinyl Radical

    OpenAIRE

    M, Pinak; H., YAMAGUCHI; R., OSMAN; Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences: Comenius University; Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences; Dept of Physiology and Biophysics, Mount Sinai School of Medicine, The City University of New York

    1996-01-01

    Molecular dynamics (MD) simulation of DNA dodecamer d (CGCGAATTTC^GCG)2 with a primary radiation damage represented by 5-hydroxy-6-cytosinyl radical (C^) in position 9 was performed with AMBER 4.0 force field with periodic boundary conditions for the solvent. The temperature, potential energy of the system, energetic contributions from groups and RMS deviation from original positions were examined throughout the course of the simulation up to 140 ps. The stabilized structure (after 100 ps) wa...

  1. β∗ levelling using the LHC Lumi Server (MD 2427)

    CERN Document Server

    Hostettler, Michi; Fuchsberger, Kajetan; Gabriel, Mathieu; Hemelsoet, Georges-Henry; Hruska, Marek; Jacquet, Delphine; Wenninger, Jorg; CERN. Geneva. ATS Department

    2018-01-01

    Luminosity levelling by β∗ is the baseline scenario for HL-LHC and will possibly be used in 2018 LHC operation. In this MD, we commissioned a novel controls approach to β∗ levelling using improved LSA trims and automatic orchestration. Compared to the regular squeeze using sequences, this approach is aimed to be minimally invasive to LHC operation in Stable Beams. Using this tool, we demonstrated the feasibility of β∗ levelling between 1 m and 30 cm.

  2. Learning from a leader: an interview with Dirk M. Elston, MD.

    Science.gov (United States)

    Elston, Dirk M; Bronfenbrener, Roman

    2014-02-01

    As residents, we all owe at least some of our knowledge base to the teachings of Dirk M. Elston, MD. I recently sat down with Dr. Elston to find out who the man is behind the work. Our discussion was both a humbling and enlightening experience for me. This interview serves to illustrate the human side of a current pioneer within our field and also to inspire our generation of emerging leaders.

  3. William Healy, M.D., Father of the American Child Guidance Movement

    Science.gov (United States)

    1981-08-01

    the University of Maryland in partial fulfillment of the requirements for the degree of Master of Arts 1981 u...Wil iam iiealy, M.D. Di t ribut iorn/ Father of the American .. Child Guidance Movement Avatlabliitv Codes Dizt Grant Huls,’ Wagner, Mastei of Art -,, 1...coming book, "The Science of Psychoanalysis " (1928). Healy was chosen president of this organization in 1926.104 Healy used his membership in national

  4. Modeling and imaging land-cover influences on air-temperature in and near Baltimore, MD

    Science.gov (United States)

    Gordon Heisler; Alexis Ellis; David J. Nowak; Ian. Yesilonis

    2015-01-01

    Over the course of 1681 hours between May 5 and September 30, 2006, air temperatures measured at the 1.5-m height at seven sites in and near the city of Baltimore, MD were used to empirically model Δ Tˆ R-p , the difference in air temperature between a site in downtown Baltimore and the six other sites. Variables in the...

  5. Measurements of $\\Delta m_d$, $\\Delta m_s$, and $\\sin 2 \\beta$ with LHCb

    CERN Document Server

    Wishahi, Julian

    2012-01-01

    We present measurements of the oscillation frequencies $\\Delta m_d$ and $\\Delta m_s$ of $B$ meson mixing as well as a measurement of the time-dependent CP-asymmetry in decays of $B^0\\to J/\\psi K_{\\text{S}}^0$ based on $1.0\\,\\text{fb}^{-1}$ of data collected by the LHCb experiment in 2011. These measurements give valuable input to tests of the unitarity of the Cabibbo-Kobayashi-Maskawa matrix.

  6. Richard Mollica, Md, Mar. Texto de salud mental global: trauma y recuperación

    OpenAIRE

    Alberto Perales-Cabrera

    2014-01-01

    This is to communicate on the book by Richard Mollica. Md, sea. Text Global Mental Health: Trauma and Recovery. Guidelines for clinical care and field trauma victims worldwide (Textbook of global mental health. Trauma and recovery A companion guide for field and clinical care of traumatized people worldwide). Edited by Harvard Refugee Trauma Program, USA, 2011m electronic version can be obtained for $ 60.00 with: http: // mollica/ www.lulu.com/shop/richard-f-textbook-of-global-mind-healthtrau...

  7. Report from LHC MD 1399: Effect of linear coupling on nonlinear observables in the LHC.

    CERN Document Server

    Maclean, Ewen Hamish; Giovannozzi, Massimo; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2017-01-01

    Simulation work during Run 1 established that linear coupling had a large impact on nonlinear observables such as detuning with amplitude and dynamic aperture. Linear coupling is generally taken to be the largest single source of uncertainty in the modelling of the LHC’s nonlinear single particle dynamics. ThisMD sought to verify that such behaviour, to this point only observed in simulation, translated into the real machine.

  8. Queueing systems with constant service time and evaluation of M/D/1,k

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk

    1997-01-01

    Systems with constant service times have the particular property that the customers leave the servers in the same order in which they areaccepted for service. Probabilitites of integral waiting times can be expressed by the state probabilities, and non-integral waiting timescan be expressed by in...... by integral waiting times. This in combination by a result by Keilson results in an effective algorithm for evaluating M/D/1,k....

  9. 78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

    Science.gov (United States)

    2013-08-05

    ....S., 74 FR 36,751, 36,755 (DEA 2009); Martha Hernandez, M.D., 62 FR 61,145, 61,147 (DEA 1997). In... determination. Mark De La Lama, P.A., 76 FR 20,011, 20,018 (DEA 2011). 2. Factors Two and Four: Applicant's... prior to this arrest, I find that this incident is relevant to factor three. But see Mark De La Lama, P...

  10. IncMD: incremental trie-based structural motif discovery algorithm.

    Science.gov (United States)

    Badr, Ghada; Al-Turaiki, Isra; Turcotte, Marcel; Mathkour, Hassan

    2014-10-01

    The discovery of common RNA secondary structure motifs is an important problem in bioinformatics. The presence of such motifs is usually associated with key biological functions. However, the identification of structural motifs is far from easy. Unlike motifs in sequences, which have conserved bases, structural motifs have common structure arrangements even if the underlying sequences are different. Over the past few years, hundreds of algorithms have been published for the discovery of sequential motifs, while less work has been done for the structural motifs case. Current structural motif discovery algorithms are limited in terms of accuracy and scalability. In this paper, we present an incremental and scalable algorithm for discovering RNA secondary structure motifs, namely IncMD. We consider the structural motif discovery as a frequent pattern mining problem and tackle it using a modified a priori algorithm. IncMD uses data structures, trie-based linked lists of prefixes (LLP), to accelerate the search and retrieval of patterns, support counting, and candidate generation. We modify the candidate generation step in order to adapt it to the RNA secondary structure representation. IncMD constructs the frequent patterns incrementally from RNA secondary structure basic elements, using nesting and joining operations. The notion of a motif group is introduced in order to simulate an alignment of motifs that only differ in the number of unpaired bases. In addition, we use a cluster beam approach to select motifs that will survive to the next iterations of the search. Results indicate that IncMD can perform better than some of the available structural motif discovery algorithms in terms of sensitivity (Sn), positive predictive value (PPV), and specificity (Sp). The empirical results also show that the algorithm is scalable and runs faster than all of the compared algorithms.

  11. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  12. The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD

    OpenAIRE

    Piomelli, Daniele; Russo, Ethan B.

    2016-01-01

    Dr. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and Medical Director of PHYTECS, a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system. Previously, from 2003 to 2014, he served as Senior Medical Advisor and study physician to GW Pharmaceuticals for three Phase III clinical trials of Sativex? for alleviation of cancer pain unresponsive to optimized opioid treatment and studies of Epidiolex? for ...

  13. Comparison of fission modes in 252Cf, 257Fm, and 260Md

    Science.gov (United States)

    van Aarle, J.; Siemon, K.; Wild, J. F.; Lougheed, R. W.; Westmeier, W.; Patzelt, P.

    1998-10-01

    Although the spontaneous-fission properties of heavy actinides have been studied for well over 35 years, many interesting and informative details continue to come into light. During the last decade, the spontaneous fission of 252Cf, 257Fm and 260Md has been extensively investigated at the Philipps University of Marburg (1-4), by means of a gadolinium-doped liquid scintillation tank for neutron counting and surface barrier detectors for fission fragment detection. The three nuclides represent the transition from the well-known asymmetric fission yield distribution, as it is characteristic for 252Cf, to a much more symmetrical one, found in the fission of 260Md. Therefore, trends in the dynamical changes of fission properties have been derived from these studies. For the spontaneous fission of 252Cf and 260Md, it was already shown that different fission modes, as proposed by theoretical calculations of Brosa et al. (5), could be separated, using the correlation between the neutrons emitted in a fission event and both the observed fission-fragment mass and the total kinetic energy (1, 2). In the case of 257Fm, no theoretical calculations for fission modes exist. However, from the fission properties of the two surrounding actinides, one can expect at least three different fission modes, namely two "standard" and the "supershort" mode. In this paper, results from the recent 257Fm experiment will be presented and compared to systematics extracted from the fission properties of other heavy actinides.

  14. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gyeonggeun; Kil, Soyeon; Kwon, Junhyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs.

  15. The bachelor's to Ph.D. STEM pipeline no longer leaks more women than men: a 30-year analysis.

    Science.gov (United States)

    Miller, David I; Wai, Jonathan

    2015-01-01

    For decades, research and public discourse about gender and science have often assumed that women are more likely than men to "leak" from the science pipeline at multiple points after entering college. We used retrospective longitudinal methods to investigate how accurately this "leaky pipeline" metaphor has described the bachelor's to Ph.D. transition in science, technology, engineering, and mathematics (STEM) fields in the U.S. since the 1970s. Among STEM bachelor's degree earners in the 1970s and 1980s, women were less likely than men to later earn a STEM Ph.D. However, this gender difference closed in the 1990s. Qualitatively similar trends were found across STEM disciplines. The leaky pipeline metaphor therefore partially explains historical gender differences in the U.S., but no longer describes current gender differences in the bachelor's to Ph.D. transition in STEM. The results help constrain theories about women's underrepresentation in STEM. Overall, these results point to the need to understand gender differences at the bachelor's level and below to understand women's representation in STEM at the Ph.D. level and above. Consistent with trends at the bachelor's level, women's representation at the Ph.D. level has been recently declining for the first time in over 40 years.

  16. The Value of Preparing PhD Students as Research Mentors: Application of Kram's Temporal Mentoring Model.

    Science.gov (United States)

    Abbott-Anderson, Kristen; Gilmore-Bykovskyi, Andrea; Lyles, Annmarie A

    The ability to successfully mentor others is an essential skill necessary for building and strengthening an infrastructure of well-prepared nurse faculty to accelerate advancements in nursing science. Mentoring is a fundamental part of the nurse faculty role, but new faculty are often unprepared to take on mentoring roles early in their academic career. Applied training in research mentoring initiated during doctor of philosophy (PhD) programs may better prepare future faculty to manage teaching and mentoring responsibilities earlier and with greater confidence. The unique opportunity exists for PhD students to engage in research mentoring with undergraduate nursing students, with probable benefits for both the mentor and the mentee. This manuscript uses Kram's temporal mentoring model as a guide to examine the training experiences of 3 PhD students mentoring undergraduate nursing students and discusses the benefits and challenges associated with these mentoring relationships. Collectively, these experiences provide preliminary support and guidance for the development and adoption of formal PhD mentor training programs to better prepare future PhD nursing faculty for their mentoring responsibilities. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Inhibition of PHD3 by salidroside promotes neovascularization through cell–cell communications mediated by muscle-secreted angiogenic factors

    Science.gov (United States)

    Zhang, Jing; Kasim, Vivi; Xie, Yu-Dan; Huang, Can; Sisjayawan, Julita; Dwi Ariyanti, Agnes; Yan, Xue-Song; Wu, Xiao-Yan; Liu, Cai-Ping; Yang, Li; Miyagishi, Makoto; Wu, Shou-Rong

    2017-01-01

    Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based treatment is currently available. Here we showed that intramuscular administration of salidroside, an active compound of Chinese herb Rhodiola, could robustly enhance blood perfusion recovery by promoting neovascularization in HLI mice. We revealed that salidroside promoted skeletal muscle cell migration and paracrine function through inhibiting the transcriptional level of prolyl-hydroxylase domain 3 (PHD3) without affecting PHD1 and PHD2. Paracrine signals from salidroside-treated skeletal muscle cells enhanced endothelial and smooth muscle cells migration, while inhibition of FGF2/FGF2R and PDGF-BB/PDGFR-β pathways abolished this effect, as well as neovascularization in HLI mice. Furthermore, we elucidated that salidroside inhibition on PHD3 might occur through estrogen receptor alpha (ERα). Together, our findings highlights the potential application of salidroside as a novel pharmalogical inhibitor of ERα/PHD3 axis for therapeutic angiogenesis in HLI diseases. PMID:28266625

  18. Mimicking titration experiments with MD simulations: A protocol for the investigation of pH-dependent effects on proteins

    Science.gov (United States)

    Socher, Eileen; Sticht, Heinrich

    2016-03-01

    Protein structure and function are highly dependent on the environmental pH. However, the temporal or spatial resolution of experimental approaches hampers direct observation of pH-induced conformational changes at the atomic level. Molecular dynamics (MD) simulation strategies (e.g. constant pH MD) have been developed to bridge this gap. However, one frequent problem is the sampling of unrealistic conformations, which may also lead to poor pKa predictions. To address this problem, we have developed and benchmarked the pH-titration MD (pHtMD) approach, which is inspired by wet-lab titration experiments. We give several examples how the pHtMD protocol can be applied for pKa calculation including peptide systems, Staphylococcus nuclease (SNase), and the chaperone HdeA. For HdeA, pHtMD is also capable of monitoring pH-dependent dimer dissociation in accordance with experiments. We conclude that pHtMD represents a versatile tool for pKa value calculation and simulation of pH-dependent effects in proteins.

  19. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  20. [PhD theses on gerontological topics in Russia 1995-2012: scientometric analysis].

    Science.gov (United States)

    Smol'kin, A A; Makarova, E A

    2014-01-01

    The paper presents a scientometric analysis of PhD theses on gerontological topics in Russian humanities (excluding economics) for the period from 1995 to 2012. During this period, 253 PhD theses (238 of "candidate dissertations," and 15 of "doctoral dissertations") were defended in Russia. Almost half of them were defended during the boom years (2005-2006; 2009-2010). The number of theses defended in the 2000-s has increased significantly compared to the second half of 1990-s. However for gerontological PhD-s overall as a percentage of all theses defended in Russian humanities, the number hardly changed and remained small (less than 0.3%). The leading discipline in the study of aging (within the humanities) is sociology accounting for more than a third of all defended theses. Though the theses were defended in 48 cities, more than half of them were defended in 3 cities, which are Moscow, St. Petersburg and Saratov. Thematic analysis showed that the leading position was occupied by two topics: "the elderly and the state" (42%) and "(re)socialization/adaptation of the elderly" (25%). 14% of the works are devoted to intergenerational relations and social status of the elderly. Other topics (old man/woman's personality, self-perceptions of aging, violence and crime against the elderly, loneliness, discrimination, etc.) are presented by very few studies.