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Sample records for bunshi kyokugen sosa

  1. Fiscal 1997 R and D project on industrial science and technology under a consignment from NEDO. R and D of the ultimate manipulation technology of atoms and molecules; 1997 nendo sangyo kagaku gijutsu kenkyu kaihatsu jigyo Shin energy Sangyo gijutsu Sogo Kaihatsu Kiko itaku. Genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho (genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This paper describes R and D of the ultimate manipulation technology of atoms and molecules (atom technology). The R and D aims at establishment of observation/manipulation technology of atoms and molecules as common basic technology in various industrial fields such as new material, electronics, bio-technology and chemistry. The R and D thus aims at establishment of observation/manipulation of solid surfaces and DNA organic molecules, formation of fine structures of atomic surface arrangement, and calculation/ simulation for predicting a reaction theorem of atom and molecule surfaces. In fiscal 1997, research was made on improvement and development of computer simulation environment, and description of an excited state of electrons by Green function. Establishment of a construction method and computation code is under investigation for pseudo- potential dependent on excitation energy. Survey was made on research trends of the atom technology by visiting overseas academic societies and institutions. International Symposium on Atom Technology was also held in Tokyo in Nov. 1997

  2. FY 1998 annual summary report on manipulation of atomic and molecular extremes. Development of technologies for high-efficiency analysis/manipulation of DNA and the like; 1998 nendo genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho. DNA nado kokoritsu kaiseki sosa gijutsu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The objectives are set to establish the techniques for observation/manipulation of atoms and molecules, as the common basic techniques for various industrial areas, e.g., new materials, electronics, biotechnology and chemical. Development of atomic field and scanning tunneling microscopes working under extreme conditions has been pursued, in order to manipulate complex systems, such as living body. For identification of molecular species, laser-excited fluorescence is combined with scanning mechanical probing to further refine the single molecule detection/identification techniques, and the objectives are set to develop a new method for evaluating molecules in a living body using a scanning probe microscope, and also to develop a novel scanning probe microscope for molecules in a living body. The other efforts were directed to R and D of the techniques for observing structures of organic molecules and the like through the measurements of adsorption process of organic molecules and clusters on semiconductor substrates and their surface reactions, and precision measurements of vibrational conditions of adsorbed molecular species reacting in the solid-liquid interfaces by high-sensitivity Raman spectroscopy to elucidate the catalysis mechanisms at the molecular level. (NEDO)

  3. FY 1999 achievement report on the project on the R and D of industrial science technology. R and D of the atom/molecule limit operation technology (Development of high-functional material formation technology for electric power generation environment); 1999 nendo genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho. Hatsuden kankyoyo kokino sozai keisei gijutsu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The paper described the FY 1999 results of the study of atomic technology. Using a combined system of the scanning tunnel microscope (STM) with the field ion microscope and the atom probe (AP), a few Ag atoms were identified. Si windows were formed by electron beam irradiated from a STM tip, and Ge nanocrystal array was formed at the windows by supplying GeH4 gas. Iron clusters were deposited on Si substrates. With those as nuclei and in self-formation for etching masks, Si pillar distribution nano-crystals were etching-processed. The oxidation process of clean Si surface using ultra-high vacuum electron spin resonance was observed, and the incomplete state of the Si oxidation process was observed. Perovskite oxide superlattices composed of the two kinds were fabricated using the laser ablation method. The layer type antiferromagnetic spin arrangement is artificially modulated in the superlattices along the stacking direction. To observe the magnetic nano-structure, the development was commenced of a spin-polarized STM. The paper theoretically analyzed the dynamic process of atoms and molecules. (NEDO)

  4. Project in fiscal 2000 of research and development of industrial and scientific technologies. Achievement report on 'research and development of ultimate atom and molecule operation technology' (development of technology to form high-function materials for electric power generating environment); 2000 nendo genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho. Hatsuden kankyoyo kokino sozai keisei gijutsu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Research and development has been performed with an intention of establishing an observation technology and an operation technology of atoms and molecules, as a common infrastructural technology in different industrial fields. This paper reports the achievements in fiscal 2000. In the research of an inorganic atom and molecule identification and operation technology, a composite device constructed of an STM and an electric field ion microscope/atom probe was used to draw out and identify two or three Ag atoms from Si:Ag surface and show clearly the correspondence with the original atomic positions. In the research of a technology to form and control nano-structures on surface and interface, Ge/Si hetero nano crystals with a size of 20 nm were formed on Si nano crystals formed on an opening in the atom layer oxide film on an Si substrate. Furthermore, hetero nano crystals of Si/Ge/Si, in which Ge nano crystals are embedded in Si nano crystals, were formed successfully. In the research of a spin electronics technology, research was performed, with regard to perovskite vanadium oxides, on decay of the orbital order due to changing the band filling, and insulating metal transition. (NEDO)

  5. Achievement report for fiscal 1998. Research and development of ultimate atom/molecule manipulating technologies (Development of technology for formation of advanced function materials for use under power generation environment); 1998 nendo genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho. Hatsuden kankyoyo kokino sozai keisei gijutsu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The aim is to establish atom/molecule observing and manipulating technologies commonly applicable as basic technologies to industrial fields of new materials, electronics, biotechnology, chemistry, etc. The technologies to be established involve atom level observation and manipulation by mechanically probing into organic molecules such as those of solid surface DNA, microstructure formation with atoms arbitrarily arranged by use of a microfine electron beam and surface chemical properties, simulation by the first principle calculation for the theoretical prediction atom/mole surface application in a process, and new materials to replace semiconductors. The subjects of research and development selected for this fiscal year are the study of silicon nanostructure formation and physical properties, study of nanostructure formation technology based on cluster manipulation, study of nanostructure formation processes using chemical reaction control and local structure analysis, study of new properties of correlation-intensive electron based new materials, study of spin measuring technology, and the study of theoretical analysis of atom/molecule dynamic processes. (NEDO)

  6. Fiscal 1997 R and D project on industrial science and technology under a consignment from NEDO. R and D of the ultimate manipulation technology of atoms and molecules (R and D of the formation of advanced materials for power generation environment); 1997 nendo sangyo kagaku gijutsu kenkyu kaihatsu jigyo Shin energy Sangyo Gijutsu Sogo Kaihatsu Kiko itaku. Genshi bunshi kyokugen sosa gijutsu no kenkyu kaihatsu seika hokokusho (hatsuden kankyoyo kokino sozai keisei gijutsu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This paper describes R and D of the ultimate manipulation technology of atoms and molecules (atom technology). Ten nanoscale Ge islands were successfully formed in proper positions on an Si substrate surface by using mask technology of nanoscale atomic layers. Growth of less-defect ZnSe films on a GaAs(110) surface was possible under various conditions. The magnetic transfer mechanism of Mn oxide with huge reluctance was clarified. Through study on selective-area deposition of Si on plasma-oxidized ultrathin SiO2 mask layers patterned by direct electron-beam exposure and an idea of SiO2/SiNx bilayer mask, direct use of the ultrathin mask layer as insulating layer in device structure was achieved. The superior property as electron beam resist of methano- fullerene composed of fullerene C60 with side chains including oxygen was clarified. The initial oxidation process of an Si(100) surface was analyzed, and the observation result by SREM was theoretically explained. Development of a high-resolution spin polarization electron microscope was also mentioned. 48 refs., 145 figs., 20 tabs.

  7. Sosa y los sueños

    OpenAIRE

    2005-01-01

    Este trabajo plantea dos asuntos a propósito del modelo alternativo que expone Ernesto Sosa en Los sueños.El primero es que, dado el modelo de soñar como imaginar/narrar, no está claro por qué surge todavía el escepticismo del sueño: si el sueño a fin de cuentas no compite epistémicamente con la vigilia, entonces el sueño no parece amenazar el crédito que ordinariamente damos a nuestras experiencias en vigilia. El segundo es que, en contraste con el modelo tradicional, el modelo de soñar como...

  8. Spherical oligo-silicic acid SOSA disclosed as possible endogenous digitalis-like factor

    Directory of Open Access Journals (Sweden)

    Franz eKerek

    2015-01-01

    Full Text Available Na+/K+-ATPase is a membrane ion-transporter protein, specifically inhibited by digitalis glycosides used in cardiac-therapy. The existence in mammals of some endogenous digitalis-like factors (EDLF as presumed ATPase ligands is generally accepted. But the chemical structure of these factors remained elusive because no weighable amounts of pure EDLF have been isolated. Recent high resolution crystal structure data of Na+/K+-ATPase have located the hydrophobic binding pocket of the steroid glycoside ouabain. Our recently disclosed spherical oligo-silicic acids (SOSA fulfill the main criteria to be identified with the presumed EDL factor. SOSA was found as a very potent inhibitor of the Na+/K+-ATPase, Ca2+-ATPase, H+/K+-ATPase and of K-dp-ATPase, with IC50 values between 0.2-0.5µg/ml. These findings are even more astonishing while so far, neither mono silicic acid nor its poly-condensed derivatives have been remarked biologically active. With the diameter ϕ between 1 - 3nm, SOSA still belong to molecular species definitely smaller than silica nano-particles with ϕ >5nm. In SOSA molecules almost all Si-OH bonds are displayed on the external shell which facilitates the binding to hydrophilic ATPase domains. SOSA is stable for long-term in solution but is sensitive to freeze-drying which could explain the failure of countless attempts to isolate pure EDLF. There is a strong resemblance between SOSA and vanadates, the previously known general inhibitors of P-type ATPases. SOSA may be generated endogenously by spherical oligomerization of the mono-silicic acid ubiquitously present in animal cells and fluids. Based on the finding that the SOSA structure is sensitive to the concentration and nature of the cationic species a presumably archaic mechanism to regulate the activity of the ATPase pumps is proposed.

  9. Sentiment Contagion Based on the Modified SOSa-SPSa Model

    Science.gov (United States)

    Song, Zhijie; Jia, Jie; Wang, Jian

    2016-01-01

    Sentiment contagion is similar to an infectious disease that spreads in a crowd. In this study, we extend the proposed SOSa-SPSa model (susceptible-optimistic-susceptible and susceptible-pessimistic-susceptible) by considering the interaction between optimists and pessimists. Simulation results show that our model is reasonable and can better explain the entire contagion process by considering three groups of people. The recovery speed of pessimists has an obvious regulative effect on the number of pessimists and the possibility of optimists coming in contact with pessimists to be infected as pessimism plays a greater role than that of reverting to susceptibility. The number of pessimists is positively related to the possibility that optimists come in contact with pessimists to become pessimistic but is negatively related to the possibility of the other way around. When the speed of spontaneous generation is slow, the number of pessimists sharply increases. However, the increase is not so apparent when the speed of spontaneous generation reaches a certain number.

  10. 索萨的德性知识论%Ernest Sosa's Epistemology of Virtue

    Institute of Scientific and Technical Information of China (English)

    陈英涛

    2011-01-01

    基于对内在论与外在论、基础论与融贯论等当代知识论主流理论的批判,索萨(Erenst Sosa)建构了新的知识理论:德性知识论.德性知识论的提出对当代知识论研究具有导向性的意义,也可以说,引领了当代知识论的合理重建.但该理论仍然受到主流学者的围剿,并没能有效完成知识论的重建任务.

  11. Gambaran Kualitas Udara dan Keluhan Gangguan Pernapasan pada Masyarakat yang Tinggal dikawasan Industri Pabrik Kelapa Sawit PTPN IV Kebun Sosa II Kabupaten Padang Lawas Tahun 2013

    OpenAIRE

    Monika, Reni

    2014-01-01

    Palm oil mill industry is an important industry producing cooking oil, industrial oil, and fuel (biodiesel). Palm oil factory can cause problems for the environment, one of which is the issue of air quality. This research aims to know the air quality and respiratory disturbances on the community live in area of oil palm industry PTPN IV garden of Padang Lawas Regency Sosa II by 2013. Type of this research is a descriptive design proportional stratification (Proportional stratified r...

  12. Research on the Evaluation of Land Intensive Use in Logistics Park:Based on SOSA and TOPSIS Method%物流园区土地集约利用评价研究*--基于SOSA-TOPSIS法

    Institute of Scientific and Technical Information of China (English)

    李玉民; 陈博文; 马晓伟

    2015-01-01

    我国物流园区增长迅速,但土地集约利用效率较低。从土地利用强度、土地投入产出、土地社会效益、土地生态效益4个方面建立评价指标体系,利用主客观赋权法、改进的TOPSIS(逼近理想点法)构建评价模型,并通过障碍度模型分析影响物流园区土地集约利用的主要因素,据此提出改进建议。%China’s logistics park is growing rapidly,but land use efficiency is obviously low. From 4 aspects of land use intensity,land input and output,land social benefits,land ecological benefits,the paper builds the evaluation index system of intensive land utilization of logistics park,constructs the evaluation model by SOSA(subjective and objective synthetic approach)and improved TOPSIS(technique for order preference by similarity to ideal solution),analyzes the main factors influencing the intensive use of land in logistics park with obstacle degree model,then puts forward the improvement suggestions.

  13. New distribution records of the savanna specialist fungus-farming ant Cyatta Sosa-Calvo et al. (Hymenoptera: Formicidae: Myrmicinae)

    Science.gov (United States)

    Feitosa, Rodrigo Machado; Vasconcelos, Heraldo Luis; Maravalhas, Jonas

    2016-01-01

    Abstract Background The fungus-farming ant genus Cyatta (Formicidae: Myrmicinae) is represented by a single species, C. abscondita Sosa-Calvo et al., known from a few localities in Brazil (in the states of Ceará, Minas Gerais, São Paulo and the Distrito Federal), and a single locality in the Misiones province, Argentina. Cyatta is known to occur predominantly in savanna habitats and occasionally in the transition zones between the Atlantic Forest and Cerrado. New information The new records reported here significantly expand the previously known distribution of Cyatta abscondita and provide further support for the intimate relation between this species and the savannas of South America. We report the first occurrence of the genus in southern Brazil (Paraná state) and the westernmost occurrence (Bolivia) of Cyatta abscondita, which extend its distribution approximately 1450 km to the west. Finally, we discuss the importance of mapping inconspicuous species in order to develop strategies for protecting endangered areas and to increase our understanding of the evolutionary history of organisms and biomes. PMID:27932931

  14. The Evaluation Method for Facilities Planning of Logistics Centre Based on SOSA and TOPSIS%基于主客观赋权和TOPSIS的物流中心规划方案评价

    Institute of Scientific and Technical Information of China (English)

    李玉民

    2011-01-01

    The scheme evaluation for facilities planning of logistics center is a multiobjective decision making problem. Based on SOSA (Subjective and Objective Synthetic Approach) and TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) , a comprehensive evaluation method is brought forward to evaluate the scheme of logistics center's facilities planning. After establishing the evaluation indexes system, ascertaining the indexes' weight by SOSA, calculating the relative approach degree as to the ideal point and negative ideal point, and then the values of these relative approach degree are obtained. Based on the values, the evaluation result and the optimum scheme could be obtained. Case analysis shows that the proposed method is effective and reasonable.%物流中心设施规划的方案评价是一个多目标决策问题.提出了一种基于主客观赋权( SOSA)和理想点法(TOPSIS)的综合评价方法,能够较好解决物流中心设施规划方案的评价优选问题.根据物流中心设施规划设计的特点和要求,建立综合评价指标体系;应用主客观赋权的方法,确定各指标在综合评价指标体系中的权重;求出各方案相应指标属性值对理想解的相对接近度;通过比较相对接近度的大小,对各个规划方案进行排序优选.应用实例表明该方法是合理有效的.

  15. Olhar sobre as metáforas cantadas por Mercedes Sosa e outros cantores durante as ditaduras militares na Argentina e outros países da América Latina

    OpenAIRE

    Elissandro dos Santos Santana

    2013-01-01

    Esse trabalho é fruto do projeto Elaboração de Material Didático para o ensino de Língua Espanhola e o recorte é a música no ensino de espanhol como língua estrangeira (ELE): uma abordagem interdisciplinar e multicultural. O corpus de investigação, letras e biografias de cantores e cantoras censurados em ditaduras da América Latina, serviu como pano de fundo para a análise de algumas das metáforas presentes nas canções interpretadas por Mercedes Sosa e outros artistas de países latino-america...

  16. Procesos de remoción en masa y erosion fluvial en la quebrada del río Los Sosa, provincia de Tucumán

    Directory of Open Access Journals (Sweden)

    D. S. Fernández

    2003-06-01

    Full Text Available Durante las últimas precipitaciones que tuvieron lugar en la quebrada del río Los Sosa en los meses de verano de 2001, se registraron numerosos movimientos de remoción en masa y eventos de erosión fluvial que afectaron severamente a la ruta Provincial 307. El costo de las reparaciones que se tuvieron que realizar en la zona ascendió a US$ 821.598, los que fueron afrontados mediante créditos externos. Los dos parámetros que tienen incidencia directa en esos procesos son: la progresiva acumulación de agua de prolongadas lluvias y la intensidad de las tormentas, a los que se suma la acción antrópica efectuada de manera intencional y/o accidental. En cuanto a los factores condicionantes, la litología y las pendientes cumplen un importante papel en el control del tipo de proceso desarrollado. Los flujos fueron observados en su mayoría en la zona donde afloran las metamorfitas de bajo grado, mientras que los deslizamientos de detritos en materiales previamente alterados por acción meteórica predominaron en la zona donde aflora la tonalita El Indio. En total se inventariaron 36 casos, correspondiendo en su mayoría a los deslizamientos superficiales, mientras que los de mayor magnitud fueron los flujos de detritos. La zona de mayor peligrosidad, que afecta a la ruta provincial 307, se encuentra ubicada entre los kilómetros 23 y 38, donde tienen lugar la mayoría de los movimientos de ladera.

  17. Procesos de remoción en masa y erosion fluvial en la quebrada del río Los Sosa, provincia de Tucumán Mass wasting and fluvial erosion processes in Río Los Sosas gulch, province of Tucumán, Argentina

    Directory of Open Access Journals (Sweden)

    D. S. Fernández

    2003-06-01

    Full Text Available Durante las últimas precipitaciones que tuvieron lugar en la quebrada del río Los Sosa en los meses de verano de 2001, se registraron numerosos movimientos de remoción en masa y eventos de erosión fluvial que afectaron severamente a la ruta Provincial 307. El costo de las reparaciones que se tuvieron que realizar en la zona ascendió a US$ 821.598, los que fueron afrontados mediante créditos externos. Los dos parámetros que tienen incidencia directa en esos procesos son: la progresiva acumulación de agua de prolongadas lluvias y la intensidad de las tormentas, a los que se suma la acción antrópica efectuada de manera intencional y/o accidental. En cuanto a los factores condicionantes, la litología y las pendientes cumplen un importante papel en el control del tipo de proceso desarrollado. Los flujos fueron observados en su mayoría en la zona donde afloran las metamorfitas de bajo grado, mientras que los deslizamientos de detritos en materiales previamente alterados por acción meteórica predominaron en la zona donde aflora la tonalita El Indio. En total se inventariaron 36 casos, correspondiendo en su mayoría a los deslizamientos superficiales, mientras que los de mayor magnitud fueron los flujos de detritos. La zona de mayor peligrosidad, que afecta a la ruta provincial 307, se encuentra ubicada entre los kilómetros 23 y 38, donde tienen lugar la mayoría de los movimientos de ladera.During summer storms in late 2000 and early 2001 several mass wasting movements and fluvial erosion episodes took place along the Río Los Sosas and caused serious damage to Provincial Road N° 307, which runs parallel to the river course. The cost of the repairs amounted to U$S 821,598, and was met by external credits. The two main environmental factors directly affecting the zone were the accumulative rainfall and the intensity of the storm. In addition, man-made alteration of the natural environment intensified the affects. Lithology and regional

  18. Olhar sobre as metáforas cantadas por Mercedes Sosa e outros cantores durante as ditaduras militares na Argentina e outros países da América Latina

    Directory of Open Access Journals (Sweden)

    Elissandro dos Santos Santana

    2013-05-01

    Full Text Available Esse trabalho é fruto do projeto Elaboração de Material Didático para o ensino de Língua Espanhola e o recorte é a música no ensino de espanhol como língua estrangeira (ELE: uma abordagem interdisciplinar e multicultural. O corpus de investigação, letras e biografias de cantores e cantoras censurados em ditaduras da América Latina, serviu como pano de fundo para a análise de algumas das metáforas presentes nas canções interpretadas por Mercedes Sosa e outros artistas de países latino-americanos como Brasil, Chile e Cuba.

  19. Research study on harmonized molecular materials (HMM); Bunshi kyocho zairyo ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    As functional material to satisfy various needs for environmental harmonization and efficient conversion for information-oriented and aging societies, HMM were surveyed. Living bodies effectively carry out transmission/processing of information, and transport/conversion of substances, and these functions are based on harmonization between organic molecules, and between those and metal or inorganic ones. HMM is a key substance to artificially realize these bio-related functions. Its R & D aims at (1) Making a breakthrough in production process based on innovation of material separation/conversion technology, (2) Contribution to an information-oriented society by high-efficiency devices, and (3) Growth of a functional bio-material industry. HMM is classified into three categories: (1) Assembly materials such as organic ultra-thin films (LB film, self-organizing film), and organic/inorganic hybrid materials for optoelectronics, sensors and devices, (2) Mesophase materials such as functional separation membrane and photo-conductive material, and (3) Microporous materials such as synthetic catalyst using guest/host materials. 571 refs., 88 figs., 21 tabs.

  20. Molecular machines in living cells. Seibutsu no bunshi kikai to sono system

    Energy Technology Data Exchange (ETDEWEB)

    Osawa, F. (Aichi Inst. of Tech., Nagoya (Japan))

    1992-12-20

    At first, flagellar motors of bacteria are reviewed as a typical example of molecular machines in living cells. A rotational motor is embedded in the cell membrane at the root of the flagellum. The driving power of the rotation is the flow of hydrogen ion from the inside to the outside of the cell. In a normal state of a bacterium, potential difference of about 0.2 V is produced by the ion pump existing in the cell membrane. A molecular motor of sliding motion of muscle attracts the attention on the relation of the input and output of the molecular motor. The mechanism of the smooth motion without fluctuation in the fluctuated environment and the fluctuated input is unknown. Next, the motion of Paramecium is discussed as an example of a system composed of a number of molecular machines. Paramecium moves to a place of a suitable temperature when placed in a water tank with temperature gradient, however, it does not stop the motion at the place of the suitable temperature and increases a probability to change the direction when leaving, that is it takes a method of indirect probabilistic control. 12 refs., 8 figs.

  1. Genetic manipulation of woody plants and its applications. Rinboku no idenshi sosa to sono oyo

    Energy Technology Data Exchange (ETDEWEB)

    Ebinuma, H. (Jujo Paper Co. Ltd., Tokyo (Japan))

    1992-06-01

    The advance of plant biotechnology has been further accelerated by the development of the new epoch-making technique typified by the DNA amplification using the PCR (polymerase chain reaction) method. In the application of plant biotechnology to trees, the introduction of useful genes into genetically elite trees and short-period mass propagation of recombinants by micropropagation are considered to be rational strategies. In the utilization of recombinants, non-edible industrial product materials such as trees are considered to pass the safety standards more easily and also to be profitable. This paper discusses the possibilities of tree recombinants, the imparting of disease-resistance to elite trees and the biosynthetic control of lignin. The paper introduces a topic that the imparting of disease-resistance to elite trees is in a stage of transference to experiments of recombinants in a closed-system greenhouse by the construction of the crown gall resistant gene and the establishment of the gene introduction system into crossed populus sieboldii miquel. 19 refs., 4 figs.

  2. FY1995 ultra-high performance semiconductor lasers for advanced optical information network; 1995 nendo kodo hikari joho tsushinmo e muketa kyokugen seino handotai laser

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The purpose of this research was to study and develop ultra-high performance semiconductor light source devices that should facilitate construction of advanced optical information networks. The semiconductor devices mentioned above are enhanced and integrated versions of distributed feedback (DFB) lasers based on 'gain coupling', which the group of the research coordinator has been investigating as a pioneer in the world. This research aimed at development of ultra-high performance semiconductor lasers that surpass the first generation conventional DFB lasers in any respect, by strengthening important device characteristics for system applications of the gain-coupled DFB lasers. The achievements of this research are listed below : 1. In-situ characterization of As-P exchange in MOVPE 2. Development of 1.55 {mu}m gain-coupled DFB lasers of absorptive grating type 3. Establishment of measurement technique for gain-coupling coefficients 4. Enlargement of small signal modulation response by the absorptive grating 5. Prediction of lower analog modulation distortion 6. Characterization of reflection-induced noise 7. Proposal and Demonstration of wavelength trimming 8. Proposal and Fabrication of GC DFB laser triode (NEDO)

  3. Structural analysis of microtubule-kinesin complex; Mota tanpakushitsu bunshi no kozo kaiseki ni yoru undo hassei kiko no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Toyoshima, Yoko [University of Tokyo, Tokyo (Japan). Graduate School of Arts and Sciences

    1998-12-16

    To understand the molecular mechanism of motor proteins which work in cell motility, the information of three dimensional structure of the complex between motor proteins and cytoskeletal filaments is important. Although crystal sacarato of kinesin motor domain and tubulin are determined respectively, their relative position in interacting state is unidentified. In this study, we made a series of several mutant kinesin motor domains which have reactive cystein using protein engineering methods, and labelled with gold clusters. Next, we formed the complex of these proteins and microtubules, and then embedded in amorphous ice. Three dimensional reconstitution of the complexes from the electron microscopic images can decide the position of the specific residue and relative position of kinesin motor domain and microtubules, which brings the structural basis to elucidate the molecular mechanism of motor proteins. (author)

  4. Study on molecular controlled mining system of methane hydrate; Methane hydrate no bunshi seigyo mining ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Kuriyagawa, M.; Saito, T.; Kobayashi, H.; Karasawa, H.; Kiyono , F.; Nagaoki, R.; Yamamoto, Y.; Komai, T.; Haneda, H.; Takahashi, Y. [National Institute for Resources and Environment, Tsukuba (Japan); Nada, H. [Science and Technology Agency, Tokyo (Japan)

    1997-02-01

    Basic studies are conducted for the collection of methane from the methane hydrate that exists at levels deeper than 500m in the sea. The relationship between the hydrate generation mechanism and water cluster structure is examined by use of mass spectronomy. It is found that, among the stable liquid phase clusters, the (H2O)21H{sup +} cluster is the most stable. Stable hydrate clusters are in presence in quantities, and participate in the formation of hydrate crystal nuclei. For the elucidation of the nucleus formation mechanism, a kinetic simulation is conducted of molecules in the cohesion system consisting of water and methane molecules. Water molecules that array near methane molecules at the normal pressure is disarrayed under a higher pressure for rearray into a hydrate structure. Hydrate formation and breakdown in the three-phase equilibrium state of H2O, CH4, and CO2 at a low temperature and high pressure are tested, which discloses that supercooling is required for formation, that it is possible to extract CH4 first for replacement by guest molecule CO2 since CO2 is stabler than CH4 at a lower pressure or higher temperature, and that formation is easier to take place when the grain diameter is larger at the formation point since larger grain diameters result in a higher formation temperature. 3 figs.

  5. Studies on molecular cloning of a binding protein for the monitor peptide and its physilogical significance; Monitapepuchido ketsugo tanpakushitsu no bunshi kuroningu to sono seiriteki igi no kaimei

    Energy Technology Data Exchange (ETDEWEB)

    Tsuzuki, Satoshi [Kyoto University, Kyoto (Japan). Graduate School of Agriculture

    1999-12-16

    The monitor peptide, its molecular weight of about 6500, was isolated from art bile-pancreatic juice as a stimulant for the secretion of a gastrointestinal hormone, cholecystokinin. We have reported a specific binding of the monitor peptide to rat small intestinal mucosal cells and that monitor peptide binding protein (receptor) seemed to have an affinity site for its regand resembling that of trypsin. In the present study, we isolated a clone from a rat small intestine cDNA library which encodes a novel trypsin-like protein with a transmembrane region. The mRNA corresponding to the cDNA of this protein was expressed in the vill in duodenum. The protein was expressed in cultured cells to examine the specific binding to {sup 125}I labeled monitor peptide. (author)

  6. Analysis of signal transduction in brain cells using molecular signal microscope; Bunshi jiho kenbikyo wo mochiita nousaibou no joho henkan kiko no kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Kawato, Suguru [The University of Tokyo, Tokyo (Japan). Dept. of Biophysics and Life Sciences

    1999-12-16

    We analyzed the signal transduction in brain neurons by real-time imaging of Ca/NO signals using the Molecular Signal Microscope. We also analyzed synthesis and action of neurosteroids in the hippocampus. We discovered steroid synthesis machinery containing cytochrome P 450 scc in hippocampal neurons. We found that pregnenolone sulfate acutely potentiated NMDA receptor-mediated Ca conductivity in hippocampal neurons. We also found that stress steroid corticosterone acutely prolonged NMDA receptor-mediated Ca{sup 2+} influx, resulting in Ca-induced neuro-toxicity. (author)

  7. Studies on the molecular mechanism of neural signaling, learning and memory; Chusu shinkei joho dentatsu to kioku{center_dot}gakushu no bunshi kiko ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Mishina, Masayoshi [The University of Tokyo, Tokyo (Japan). Dept. of Molecular Neurobiology and Pharmacology

    1999-12-16

    To examine the functional roles in vivo of the diverse glutamate receptor (GluR) channel subunits, we generated mutant mice defective in respective subunits. Mutant mice defective in the GluR{epsilon} 1 subunit of the NMDA-type GluR channel exhibited increased thresholds for both hippocampal synaptic plasticity and contextual maze learning, suggesting that synaptic plasticity is a cellular bases of learning and memory. The NMDA receptor channel GluR{epsilon} 2 subunit mutant mice showed impairments in the formation of the whisker-related neuronal barrelette structure in the brainstem trigeminal nucleus and synaptic plasticity in the hippocampus. Analyses of the mutant mice revealed that the GluR{delta} 2 subunit, selectively localized in cerebellar Purkinje cells, was essential in motor learning and cerebellar LTD and in Purkinje cell synapse formation. Our results suggest that some of the GluR channels play important roles in neural network formation during brain development and in higher brain function. (author)

  8. Report on achievements in fiscal 1998. Development of a technology to measure biological molecular interactions; 1998 nendo seitai bunshi sogo sayo no keisoku gijutsu no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    It has been indicated possible in principle in recent years to measure biological molecular interactions with the molecules in the living state by combining the technologies called the co-focussing optical system and the fluorescence correlation spectroscopy (FCS). The FCS method is a method capable of analyzing concentrations, sizes, and inter-molecule interactions through detection of fluorescence fluctuation in single molecules in submicron zones. In spite of the FCS method being a very effective method to measure interactions in biological molecules, the technology has not reached a level that allows easy utilization under the present condition. The present research and development is intended to solve the technological problems in the FCS method in the co-focussing optical system, and perform as many research and development works as possible in a short time to establish a technological foundation that can be provided to bio-industrial and medical sites. Particularly, in order to make the utilization thereof possible in measuring biological molecular interactions in cells, a measuring technology using the bi-photon excited fluorescence correlation spectroscopy was established with an objective to reduce damages to cells and their internal micro organs, and minimize effects of interference signals from the own fluorescence. (NEDO)

  9. Coal structure construction system with construction knowledge and partial energy evaluation; Kochiku chishiki to bubunteki energy hyoka ni yoru sekitan bunshi kozo kochiku system

    Energy Technology Data Exchange (ETDEWEB)

    Okawa, T.; Sasai, T.; Komoda, N. [Osaka University, Osaka (Japan). Faculty of Engineering

    1996-10-28

    The computer aided coal structure construction system is proposed, and a computational construction example is presented. The coal structure construction engine of this system fabricates molecular structure by connecting fragments sequentially inputted through a user interface. The best structure candidate is determined using construction knowledge and partial energy evaluation every addition of one fragment, and this process is subsequently repeated. The structure evaluation engine analyzes the 3-D conformation candidate by molecular dynamics, and evaluates the conformation by determining the energy value of an optimum structure. As an example, this system was applied to construction of coal molecular structure based on the actual data of partial structure composed of 26 structures from 2l kinds of aromatic cluster structures, 27 bonds from 2 kinds of bridged bonds, and 16 groups from 2 kinds of terminal substitutional groups. As a result, this system could construct a superior structure according to expert knowledge from the viewpoint of energy. 6 refs., 5 figs., 2 tabs.

  10. Study of the influence of microgravity on the biological cells and molecular level; Seitai saibo bunshi level ni okeru bisho juryoku no eikyo ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The shape of osteoblast, gene appearance, gene of rice blast, cellular fusion of plants, gravity acceptance mechanism of unicellular organisms, and physiological and immunity functions of mice were investigated under the microgravity condition. The influence of gravity on the vital reaction and the influence of microgravity on the crystallization of vital substances were also investigated. For the observation of osteoblast, the fluorescence dye reacted with Ca was well taken in the cells. The microgravity affected the stability of rice blast, but hardly affected the protoplast culture of mushroom. The reaction of ciliate against the gravity related to the specific gravity difference between cells and outer liquid. The level of adrenaline in blood of mice increased during the drop. The moving speed of trigger waves of chemical parallel slit formed at the BZ reaction under the microgravity became 60% to 80% of that on the ground. In the case of crystallization at the deposition agent concentration of 1% to 4%, the turbidity showing the degree of crystallization changed complicatedly. Nine processes of crystal growth were recognized. 21 refs., 55 figs., 1 tab.

  11. Acquisition method of the peculiar recognition molecule for separation and analysis; Bunri {center_dot} bunseki no tameno tokuiteki ninshiki bunshi no shutokuho

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Shigeo; Murao, Kenji [Kobe University, Kobe (Japan)

    1999-04-05

    In this review on acquisition method of the peculiar recognition molecule for separation and analysis, the following were outlined: Protein production which fused the affinity tag for the specific separation and selection process of monoclonal antibody from combinatorial library. And, the usefulness of anti-peptide antibody in the immunisation affinity separation was described. N- of the separation object protein or anti-peptide antibody for the peptide of the C- end part adsorbed antigen peptide and object protein, and the adsorption protein was able to be eluted under the moderate condition in the eluate including the antigen peptide. (translated by NEDO)

  12. Control of population of excited nitrogen molecules by mixing hydrogen in low pressure discharge; Chisso jun`antei reiki bunshi mitsudo no quenching ni yoru seigyo no kento

    Energy Technology Data Exchange (ETDEWEB)

    Uematsu, K.; Yumoto, M.; Sakai, T. [Musashi Institute of Technology, Tokyo (Japan)

    1998-06-01

    The authors have studied on surface treatment of PTFE by a low pressure discharge. It is deduced that excited nitrogen molecules contribute to introduce polar components on the surface. To confirm the speculation, we tried to change population of metastable nitrogen N2 (A{sup 3}{Sigma}u{sup +}) by quenching precursor N2 (B{sup 3}{pi}g), with hydrogen molecule. The decrease of relaxation time which indicates a change of excited molecule and measured by emission spectroscopy using a time after glow method was obtained. As a result, the relaxation times of N2 (B{sup 3}{pi}g) and N2 (A{sup 3}{Sigma}u{sup +}) decreased to 55% and 20% respectively, when mixing ratio of hydrogen was 3%. It was also deduced that hydrogen atom may take a part in a quenching process of N2 (A{sup 3}{Sigma}u{sup +}). 14 refs., 11 figs., 1 tab.

  13. Radiative decay coefficients of highly ionized state in SOSA model%SOSA模型下高剥离态的辐射衰减速率系数

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 程新路; 张茹; 杨向东; 孟川民; 何绍奎

    2003-01-01

    在SOSA模型下,计算得出Ni-like、Cu-Like、Zn-like(Xe、Gd、Dy、Au)离子的3d-nf(n=4,5,6)的辐射衰减速率系数Ar,结果表明,由于旁观电子和核电荷数的不同,使辐射衰减速率系数呈规律性变化,同时对Ni-like Ta45+的辐射衰减速率系数与采用相对论参数势方法得出的辐射衰减速率系数作了比较,结果比较一致.

  14. Autoionization Rates Coefficients of Highly Ionized State in SOSA Model%SOSA模型下高剥离态的自电离系数

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 程新路; 李小红; 杨向东

    2001-01-01

    在SOSA模型下,计算得出Ni-like、Cu-like、Zn-like(Xe、Gd、Dy、Au)的3d-nf(n=4,5,6)的自电离系数Aa,结果表明,由于旁观电子对slater积分Rk的影响,使自电离系数呈规律性变化,同时对Ta45+的自电离系数与采用相对论参数势方法得出的自电离系数作了比较,结果比较一致.

  15. 索萨的德性知识论:问题与前景%Sosa's Virtue Epistemology: Problems and Prospects

    Institute of Scientific and Technical Information of China (English)

    方红庆

    2013-01-01

    过去四十多年来,索萨为一种复杂和深刻的知识理论提供了强有力的辩护,开辟了一个新的知识论流派,即德性知识论.这是一种基于理智德性的知识理论,它试图从信念形成的过程可靠性转向认知主体能力的可靠性,从而为知识寻找一个更为宽泛和稳定的基础.然而,一方面它可能具有可靠主义的通病,例如普遍性问题,另一方面,他的德性概念过于单薄,而且基本上是后果论式的,在解释力上存在缺陷.尽管如此,这是一条通向知识的希望之途.

  16. Operating condition and membrane thickness of microcapsules generated by complex coacervation method; Coacervation ho ni yoru seisei microcapsule no sosa joken to capsule makuatsu

    Energy Technology Data Exchange (ETDEWEB)

    Kage, H.; Ogura, H.; Matsuno, Y. [Kyushu Institute of Technology, Kitakyushu (Japan); Kunimasa, M. [Takeda Chemical Industries, Ltd., Osaka (Japan); Kawahara, H. [Dainippon Ink Chemicals, Inc., Tokyo (Japan)

    1996-03-10

    Microencapsulation of glass beads with a narrow size distribution was carried out by complex coacervation of gelatin and acacia. The coacervation process was observed in detail and the effects of agitation strength, cooling rate, addition time of core material, addition plans of acetic acid and distilled water, and heating rate in the hardening process on membrane thickness of the microcapsules were investigated systematically. The membrane thickness of the microcapsules increased under the operating conditions where low cooling rate and relatively strong agitation were utilized, and pH was changed moderately by discrete addition of acetic acid or distilled water over a certain time interval. It became clear that strict control of operating conditions at 19{degree}C in the cooling process where the viscosity of the coacervate suddenly increases is remarkably important for the control of membrane thickness. 3 refs., 9 figs., 3 tabs.

  17. SOSA – a new model to simulate the concentrations of organic vapours and sulphuric acid inside the ABL – Part 1: Model description and initial evaluation

    DEFF Research Database (Denmark)

    Boy, M.; Sogachev, Andrey; Lauros, J.;

    2011-01-01

    , transport and chemistry in the ABL in and above a vegetation canopy using tower measurements from the SMEAR II at Hyytiälä, Finland and available soundings data from neighbouring meteorological stations. Using the sounding data for upper boundary condition and nudging the model to tower measurements...

  18. SOSA – a new model to simulate the concentrations of organic vapours and sulphuric acid inside the ABL – Part 1: Model description and initial evaluation

    DEFF Research Database (Denmark)

    Boy, M.; Sogachev, Andrey; Lauros, J.;

    2010-01-01

    , transport and chemistry in the ABL in and above a vegetation canopy using tower measurements from the SMEAR II at Hyytiälä, Finland and available soundings data from neighbouring meteorological stations. Using the sounding data for upper boundary condition and nudging the model to tower measurements...

  19. Optimal operation policy for three types of batch distillation columns separating binary components; 2seibun bunri bacchi joryuto no saiteki kozo to saiteki sosa

    Energy Technology Data Exchange (ETDEWEB)

    Noda, M.; Hasebe, S.; Hashimoto, I. [Kyoto Univ. (Japan)

    1997-11-01

    The optimal reflux operation which minimizes energy consumption is derived for rectifying, stripping, and total reflux columns separating binary components. The batch distillation columns are modeled as differential and algebraic equation (DAE) systems. First, each DAE system is converted to a set of algebraic equations using orthogonal collocation on finite elements. Then, the problem of finding the optimal reflux policy is formulated as a nonlinear programming problem, and it is solved using successive quadratic programming techniques. The results of the example problems show that the separation performance of the total reflux column can be improved considerably by optimizing the reflux flow rate, though the separation performance of the rectifying column can not be improved so much, even if the reflux ratio is optimized. As a result, the energy consumption of the total reflux column is equal to or less than that of the rectifying column in most cases. The reason why the separation performance of the stripping column is worse than those of the other columns is made clear using the characteristics of vapor liquid equilibrium. 4 refs., 5 figs., 3 tabs.

  20. FY 1998 achievement report on the R and D project on industrial science technology. Development of a functional biomolecule analysis/synthesis system; 1998 nendo kinosei seitai bunshi kaiseki gosei system no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the purpose of developing the technology required for the biotechnology industry, a study was made on proteins having ligand recognition function, and the FY 1998 results were reported. In the technology development of a system for various/diversified syntheses of functional molecules, a system was designed/trially manufactured which enables the simultaneous synthesis of various biological/functional substances (compound library) at high-efficiency. In the development of the structure analysis system of ligand recognized proteins, a high-efficient biopolymer analysis system was developed which is based on TOF (time-of-flight) mass spectrometer and analyzes proteins produced by recombined genes quickly and precisely. In the R and D of functional molecules using ligand recognized proteins, the cloning was successfully made of the human estrogen receptor gene hER {alpha}, which is composed of 1,785 bp, from MCF-7-BOS. Further, the bioassay system for estrogen-like substances using MCF-7 cells was established. (NEDO)

  1. Synthesis of New Branched Polysaccharide by Ring-Opening Polymerization of Anhydro-deoxyglucose Derivative and the Subsequent Glycosylation of the Polysaccharide Derivative; Musui deokishigukoru yudotai no kaikan jugo oyobi porima eno tofuka ni yoru shinki bunshi taso no gosei

    Energy Technology Data Exchange (ETDEWEB)

    Hatanaka, Ken`ichi.; Ota, Sanae.; Kasuya, M.C.Z.; Kanno, Ken`ichi. [Tokyo Institute of Technology, Tokyo (Japan). Department of Biomolecular Engineering

    1998-11-10

    1,6-Anhydro-2-deoxy-glucose derivatives having two kinds of protective groups were polymerized and copolymerized in order to synthesize branched polysaccharides. Deoxy-glucose monomers showed high polymerizability. The obtained polymer was selectively deprotected and then glucosylated to give 2-deoxy-(1{yields}6)-{alpha}-D-glucopyranan with glucose branch at C-3. In the present report, it is firstly described that the comb-shaped branched polysaccharide (100% branching) was synthesized by the glycosylation of the polysaccharide derivative. (author)

  2. New development of molecular imprint method. Transcription of structural property of protein on nanometer structure surface; Bunshi inpurinto ho no shintenkai -tanpakushitsu no kozo tokusei wo nano kozo hyomen ni tenshasuru

    Energy Technology Data Exchange (ETDEWEB)

    Araki, Y.; Goto, M. [Kyushu Univ., Fukuoka (Japan)

    2000-04-05

    The molecule imprint method collects the attention as the technique which newly creates a separation material having molecular recognition ability, and research on it is actively carried out. It becomes possible that the recognition site for the purpose molecule (the mold molecule) is very conveniently constructed in a high molecule matrix without requiring precise molecular design and multistage synthesis by utilizing this method. However, as almost of the research conducted until now utilizes the molecular recognition in an organic solvent to carry out the polymerization, application examples of the water-soluble molecule such as the organism relative materials are little. Recently, H. Shi et al. of the Washington University have succeeded in the adjustment of the polymer membrane which has on its surface a recognition site of the protein by the molecule imprint method. Various protein molecules as the mold molecules can high-selectively be recognized by absorbing mold protein in mica, and constructing nanometer holes containing chemical structural information in the polymer membrane surface. (NEDO)

  3. Quantum analysis in the transition process to excited state of an oxygen molecule induced by electron collisions; Denshi shototsu ni tomonau sanso bunshi ni okeru reiki jotai sen`i no ryoshironteki kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Ishimaru, K. [Gifu National College of Technology, Gifu (Japan); Okazaki, K. [Tokyo Inst. of Technology, Tokyo (Japan)

    1996-06-25

    For understanding of fundamental chemical reactions under a highly non equilibrium condition which is quite often used in plasma processing, the relevant atomic and molecular processes must be clarified. In this study, an analysis of the transition process to the excited state of an oxygen molecule induced by electron collisions in the oxygen plasma has been carried out. First, the electron density distribution in an oxygen molecule has been calculated using the extended Huckel molecular orbital method. Then, the electron potential energy distribution in the transition process to the excited state has been estimated. The electron behavior has been calculated using the estimated unidimensional electron potential energy distribution and unsteady quantum mechanics. As a result, the transition process to the excited state of an oxygen molecule induced by electron collisions and its conditions have been clarified qualitatively. 9 refs., 9 figs.

  4. Wall effect in deactivation of excited molecular oxygen {sup 1}{delta}g; Reiki sanso bunshi {sup 1}{delta}g no shikkatsu ni oyobosu hyomen hanno no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, S.; Hasegawa, Y.; Yamashita, I. [Mechanical Engineering Laboratory, Tsukuba (Japan)

    1993-10-25

    This paper discusses effects of surface reaction on deactivation of excited molecular oxygen in {sup 1}{Delta}g condition. Gaseous oxygen containing excited oxygen generated by microwave discharge at a concentration of less than 1% is flown into several kinds of tubes to be measured such as quartz tubes (with an inner diameter of about 10 mm), and the light emitting intensity of the excited oxygen was measured upstream and downstream of the tubes to be measured (with in-tube pressure of 1 Torr or 2 Torr) to derive its concentration change. The surface reaction on the tube wall was regarded as a primary reaction, and the concentration change of the excited oxygen in flows in the round tube (attributable to the surface reaction) was analyzed. With respect to effects of tube wall materials on deactivation of the excited molecular oxygen, the surface deactivation probability in the case of using low-activity materials has decreased in the order of Pyrex, PVC, quartz, PFA and PTFE. The surface deactivation probability in the case of using a metallic material, SUS316L, was about 1000 times larger than that in the quartz. 14 refs., 7 figs., 1 tab.

  5. Species and distribution of Medicine Plant Resources of Sosa and Kadsura in Guizhou%黔产蔷薇属南五味子属药用植物品种资源调查研究

    Institute of Scientific and Technical Information of China (English)

    胡奇志; 张天伦; 胡期丽

    2015-01-01

    为了摸清黔产海桐花属、茴芹属和糯米团属药用植物的种类和分布情况,采用野外考察、标本采集、分类鉴定和资料考证相结合的方法对黔产海桐花属、茴芹属和糯米团属药用植物资源进行了调查.结果表明:贵州分布有蔷薇属、南五味子属药用植物资源17种,其中,蔷薇属14种,南五味子属3种,作为贵州民族习用药,部分种类具有固精、缩尿、涩肠、止带等功效,部分种类可用于治疗烧烫伤、不孕症等.

  6. 理智德性与认知视角——论欧内斯特·索萨的德性知识论%Intellectual Virtue and Epistemic Perspective——On Sosa's Virtue Epistemology

    Institute of Scientific and Technical Information of China (English)

    郝苑

    2011-01-01

    受亚里士多德的德性伦理学的启发,索萨系统建构了德性知识论.通过将"理智德性"与"认知视角"引入知识论,德性知识论力图超越传统知识论的局限,合理把握人类认知的主观性与客观性的张力.索萨的德性知识论不仅在当代知识论中具有不可忽视的首创性和重要性,而且也为重新审视知识与德性的关系带来了新的启发.

  7. Study on stability and controllability of high-speed tracked vehicles. ; Linear model and response characteristic. Kosoku soki sharyo no sosa anteisei ni tsuite. ; Senkei model to oto tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Kitano, M.; Watanabe, K.; Nagatomo, N. (National Defence Academy, Kanagawa, (Japan))

    1990-04-01

    The study on the steerability and stability of tracked vehicles is carried out by a linear equation of motion. In order to comprehend systematically the characteristic of motion of tracked vehicles, a linear equation of motion was developed from the conventional non-linear equation. With clarifying the applicable linear range, the validity of the linear model was confirmed by numerical results of the non-linear model and experimental results by using a scale model. It became clear that the motion of tracked vehicles was comprehended through this linear model, and that the motion was stable under some range of vehicle-speed and steering-ratio, because the response of the motion was damped without oscillation. In addition, it became clear through the simulation of transient and frequency responses that for improvement of the dynamics of a high-speed tracked vehicle, increase of the friction coefficient between the track and ground or appropriate selection of steering frequency was very important. 5 refs., 12 figs., 1 tab.

  8. FY1995 study of evaluating satisfaction of communication devices and brain computer interface for severely disabled people; 1995 nendo judo shogaisha no communication eido sosa shudan to tekisetsusa ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Until now, the prescription of communication devices for disabled people has been dependent on the experience of technical experts who are working for them. To improve this situation, the aim of present study is to develop the objective methods for evaluating satisfaction of communication devices. Further aim of this study is to get the basic data for using electroencephalogram for thinking switch of communication devices. 1) Under imaging real communication devices, the menu of two experimental subjects were designed with three tasks which have different difficulty. Five physiological indexes (heart rate, coefficient of variation of R-R intervals, respiration rate, skin temperature and plethysmograph), which are known to closely correlated with mental stress, were studied during three different tasks in each experimental subject. In addition, psychological test were also performed before and after each tasks. In the first subject a significant difference was detected only in psychological test among three tasks. This result may come from the small difference of difficulty in each tasks of the first subject. In the second subject, significant differences were observed in the coefficient of variation of R-R intervals, the respiration rate and psychological test. Other physiological indexces, skin temperature, heart rate and plethysmograph, may be useful. However, the reconsideration will be needed to find the usefulness of these indexes for evaluating mental stress. 2) Biofeedback control of mu rhysm, an electrical brain wave, was investigated for the possibility of thinking switch in three graduate students. In one of three students, changes of amplitude were observed bilaterally although we had expected the unilateral change. Further studies will be needed to clarify the best method of biofeedback experiment. (NEDO)

  9. Acute Blast Injury Reduces Brain Abeta in Two Rodent Species

    Science.gov (United States)

    2012-12-01

    De Gasperi 1,2,3, Miguel A. Gama Sosa1,2,3, Soong Ho Kim4, John W. Steele4,5, Michael C. Shaughness6, Eric Maudlin-Jeronimo6, Aaron A. Hall 6...Wetzlar, Ger- many). Immunohistochemical staining was performed as previ- ously described ( Gama Sosa et al., 2010) using a rabbit anti-APP antibody APP369...Traumatic brain injury: football, warfare, and long- term effects. N. Engl. J. Med. 363, 1293–1296. Elder, G. A., Dorr, N. P., De Gasperi, R., Gama Sosa, M. A

  10. Dream Skepticism and the Conditionality Problem

    DEFF Research Database (Denmark)

    Ahlström, Kristoffer

    2011-01-01

    Recently, Ernest Sosa (2007) has proposed two novel solutions to the problem of dream skepticism. In the present paper, I argue that Sosa's first solution falls prey to what I will refer to as the conditionality problem, i.e., the problem of only establishing a conditional---in this case, "if x......, then I am awake," x being a placeholder for a condition incompatible with dreaming---in a context where it also needs to be established that we can know that the antecedent holds, and as such can infer the consequent, i.e., "I am awake." Sosa's second solution in terms of so-called reflective knowledge......, I conclude that Sosa has not solved the problem of dream skepticism....

  11. Study on the ratio of Ni-like Au and Ga-like Au 3d -5f SOSA in Au laser produced plasma%金等离子体中类Ni和类Ga离子跃迁子阵强度比研究

    Institute of Scientific and Technical Information of China (English)

    程新路; 张红; 杨向东; 张继彦; 杨国洪

    2005-01-01

    用Cowan的原子结构从头算程序和SOSA模型计算各阶电离的金离子的能级结构和跃迁过程,在简化的碰撞辐射模型下求解能级布居数方程,计算了给定密度、不同电子温度下的金等离子体的理论合成谱.研究了类Ni和类Ga离子之间的共振线的强度比随电子温度的变化规律,利用这一变化规律可以为等离子体诊断提供辅助的方法.

  12. Theoretical calculation of the spectrum in the range of 0.47nm ~ 0.525nm for Ne-like Rb using SOSA model%SOSA模型下类氖铷离子在0.47nm~0.525nm范围内光谱的理论计算

    Institute of Scientific and Technical Information of China (English)

    张娟; 张红; 程新路

    2011-01-01

    用SOSA模型详细计算了部分类氖铷线相对于基态的能量和类氖铷离子在0.47nm ~ 0.525nm范围内的跃迁谱.计算得到的类氖铷线相对于基态能量比已有的结果更接近实验值.47nm~0.525nm范围内类氖铷跃迁谱的线谱参数由FAC程序计算得出,其带状谱中平均波长在该范围内的子阵的主要特征参数,即平均波长、半高宽和总跃迁强度由SOSA模型计算得出.的理论谱与实验谱符合得很好.

  13. 第二节螺旋藻市场概览

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    世界上第一座螺旋藻工厂,由Sosa Texcoco公司于1973年建成投产。Sosa Texcoco湖是一个苏打湖,位于墨西哥城东北近郊。这个湖无论水质还是气候都适于螺旋藻生长。七十年代初开始工厂化生产设计施工,1973年建成投产。直到现在该公司的的产量维持在300吨左右。

  14. Book Review Society and the object. Views from the identity, design and information / Reseña La sociedad y el objeto. Miradas desde la identidad, diseño e información

    Directory of Open Access Journals (Sweden)

    Jesús Manuel Fitch Osuna

    2014-03-01

    Full Text Available Book Review: Mercedes Mercado; Álvaro Ríos; Liliana Sosa; and Gerardo Vázquez (2012 Identity, design, information. Publisher: University of Nuevo León, Monterrey (Mexico. Pages: 195. ISBN: 978-607-27-0016-1. Reseña del libro: Mercedes Mercado; Álvaro Ríos; Liliana Sosa; y Gerardo Vázquez (2012: Identidad, diseño, información. Editorial: Universidad Autónoma de Nuevo León, Monterrey (México. Páginas: 195. ISBN: 978-607-27-0016-1.

  15. Fingerprinting antioxidative activities in plants

    Science.gov (United States)

    Saleh, Livia; Plieth, Christoph

    2009-01-01

    Background A plethora of concurrent cellular activities is mobilised in the adaptation of plants to adverse environmental conditions. This response can be quantified by physiological experiments or metabolic profiling. The intention of this work is to reduce the number of metabolic processes studied to a minimum of relevant parameters with a maximum yield of information. Therefore, we inspected 'summary parameters' characteristic for whole classes of antioxidative metabolites and key enzymes. Results Three bioluminescence assays are presented. A horseradish peroxidase-based total antioxidative capacity (TAC) assay is used to probe low molecular weight antioxidants. Peroxidases are quantified by their luminol converting activity (LUPO). Finally, we quantify high molecular weight superoxide anion scavenging activity (SOSA) using coelenterazine. Experiments with Lepidium sativum L. show how salt, drought, cold, and heat influence the antioxidative system represented here by TAC, LUPO, SOSA, catalase, and glutathione reductase (GR). LUPO and SOSA run anti-parallel under all investigated stress conditions suggesting shifts in antioxidative functions rather than formation of antioxidative power. TAC runs in parallel with GR. This indicates that a majority of low molecular weight antioxidants in plants is represented by glutathione. Conclusion The set of assays presented here is capable of characterising antioxidative activities in plants. It is inexpensive, quick and reproducible and delivers quantitative data. 'Summary parameters' like TAC, LUPO, and SOSA are quantitative traits which may be promising for implementation in high-throughput screening for robustness of novel mutants, transgenics, or breeds. PMID:19171044

  16. La construcción simbólica del tejido social : adaptación y protección de la población en situación de desplazamiento forzado /

    OpenAIRE

    Zapata Jiménez, Myriam Alba sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Estudios Latinoamericanos, presenta Myriam Alba Zapata Jiménez ; asesor Ignacio Sosa Álvarez, Horacio Crespo, Alexander Betancourt Mendieta. 344 páginas : ilustraciones. Doctorado en Estudios Latinoamericanos UNAM, Facultad de Filosofía y Letras, 2009

  17. Modificación estructural de la lignina extraída a partir de carbones de bajo rango para la obtención de madera sintética

    Directory of Open Access Journals (Sweden)

    Jesús Álvaro Jiménez Montoya

    2011-06-01

    Full Text Available The Universidad Distrital Francisco José de Caldas Coal Research Group has been working with lignin extraction from peat and low rank coal and using the obtained extract for synthetic wood industry. Sosa, sulfate and bisulfite methods [1] were applied in the first research step and later they were modified with the lignine extraction process from pine and cedar. Among these, Sosa method showed asthe more efficient method, so, it was used to extract lignine from low rank coal. The extracted lignin was used to prepare lignin-phenol-formaldehide resin and it works as natural fiber binder [2].In the second research step, standarization Sosa method was made [3], were pressure was modified using an pressure reactor (autoclave for a peat sample. Efficiency was improved. The obtained lignine was used to prepare resins such as phenolformaldehide- lignin, resorcinol-formaldehydelignin and polypropilen-lignin. All of them were utilized using sugar cane bagasse as natural fiber. Currently, a third research step is being developed using Sosa method and working with a peat sample.The main purpose, is to modificate the extracted lignin structure by UV radiation (physical methot and with NaOH (Chemical method so the lignin reactivity is improved in the resins production [4] and as result, to get a better quality synthetic wood.

  18. A Three-Part Theory of Critical Thinking: Dialogue, Mental Models, and Reliability

    Science.gov (United States)

    2000-08-01

    Goldman, 1992, 1986; Dretske, 1983; Nozick , 1981; Sosa, 1991; Plantinga, 1993). According to one version of externalism, called reliabilism ( Nozick , 1981... Nozick , R. (1981). Philosophical explanations. Cambridge, MA: Harvard University Press. Patel, V. L. & J., G. G. (1991). The general and specific nature

  19. Fiscal 1997 project on the R and D of industrial scientific technology under consignment form NEDO. Report on the results of the R and D of technologies to invent original high-functional materials (technical development of structure control materials / R and D of molecular harmonized materials); 1997 nendo sangyo kagaku gijutsu kenkyu kaihatsu jigyo Shin Energy Sangyo Gijutsu Sogo Kaihatsu Kiko itaku. Dokusoteki kokino zairyo sosei gijutsu no kenkyu kaihatsu (kozo seigyo zairyo gijutsu kaihatsu) bunshi kyocho zairyo no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    By establishing microtechnology using molecular-level bottoming-up (molecular harmonization) by imitating the system of living organism, the paper described the R and D of molecular harmonized materials aiming at developing high-functional/high-performance materials such as high-performance catalyst, photo-information functional materials and sensing materials. Under consignment from NEDO, Japan Chemical innovation Institute started the 5-year plan in fiscal 1997. Self-assembled molecular films, in which organic molecules are orderly arranged by self-assembly, aim at developing new memory/optical/sensing materials. Mesophase materials which are such materials as liquid crystal showing the intermediate state between solid and liquid, develop optical/photoconductive materials using precise molecular orientation controllability. Macroporous materials are such substances as zeolite having molecular size micro pores. The paper aims at establishment of synthesis techniques of them and development of high-performance catalyst, etc. using them. In the comprehensive investigational research, conducted was a survey of the trend overseas in addition to a study of subjects in question. Further, the supporting basic study was reconsigned to universities, etc. 57 refs., 62 figs., 17 tabs.

  20. Percepciones del suicidio en Chichí Suárez, Yucatán, y el discurso utilizado para reportarlo en el diario por Esto! /

    OpenAIRE

    Hernández Ruiz, Laura

    2011-01-01

     tesis que para obtener el grado de Doctor en Antropología, presenta Laura Hernández Ruiz ; asesor Mario Alberto Castillo Hernández, Bárbara Blaha D. Pfeiler, Mario Humberto Ruz Sosa. vii, 325 páginas : ilustraciones. Doctorado en Antropología UNAM, Facultad de Filosofía y Letras, 2011

  1. Dissecting and Targeting Latent Metastasis

    Science.gov (United States)

    2015-09-01

    K. J. Malmberg, Prospects for the use of NK cells in immunotherapy of human cancer . Nature reviews . Immunology 7, 329-339 (2007). 39. G. P. Dunn, L... reviews . Cancer 10, 871-877 (2010). 7. M. S. Sosa, P. Bragado, J. A. Aguirre-Ghiso, Mechanisms of disseminated cancer cell dormancy: an awakening field...Nature reviews . Cancer 14, 611-622 (2014). 8. A. F. Gazdar, J. D. Minna, NCI series of cell lines: an historical perspective. Journal of cellular

  2. Gaining the Edge: Connecting with the Millennials

    Science.gov (United States)

    2008-12-01

    happening in America and abroad. Footage from Vietnam (with frequent enemy body counts) along with the Watergate scandal and the anti-war riot at Kent...Powerful Influences: People MLK, Nixon , JFK, Cleavers, Rosa Parks, Osmonds, Beatles, Partridge family No real heroes (all getting in trouble...Sammy Sosa, Venus and Serena Williams Powerful Influences: Places Watergate , Hanoi, Kent State, USSR, Somalia, Chernobyl, Chat rooms, cyberspace

  3. Seroincidence and Phylogeny of Human Immunodeficiency Virus Infections in a Cohort of Commercial Sex Workers in Montevideo, Uruguay

    Science.gov (United States)

    2005-01-01

    Health, Ministry of Health, Montevideo, Uruguay; Microbiology Department, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina; U.S...7014. Sergio Sosa- Estani and Mercedes Weissenbacher, Microbiology Department, School of Medicine, University of Buenos Aires, Paraguay 2155, Piso 11...Carrion G, Sanchez JL, Russell K, Robb M, Birx D, McCutchan F, Carr JK, 2002. Molecular epidemiology of HIV type 1 in Ecuador , Peru, Bolivia, Uruguay

  4. Efectos de la entrevista motivacional en el tratamiento de la diabetes mellitus tipo 2 /

    OpenAIRE

    García Flores, Raquel

    2012-01-01

     tesis que para obtener el grado de Doctorado en Psicología, presenta Raquel Garcia Flores ; asesor Juan José Sánchez Sosa, Samuel Jurado Cárdenas, Ana Luisa González Celis Rangel, Gilda Gómez Pérez Mitré, Javier Nieto Gutiérrez235 páginas : ilustracionesDoctorado en Psicología UNAM, Facultad de Psicología, 2012

  5. Esguince cervical agudo : evaluación e intervención psicofisiológica /

    OpenAIRE

    Gálvez Hernández, Carmen Lizette

    2012-01-01

     tesis que para obtener el grado de Doctorado en Psicología, presenta Carmen Lizette Gálvez Hernández ; asesores Irma Yolanda del Río Portilla, Juan José Sánchez Sosa, Julieta Ramos Loyo, Ma. Dolores Rodriguez Ortiz, Benjamín Domínguez Trejo186 páginas : ilustracionesDoctorado en Psicología UNAM, Facultad de Psicología, 2012

  6. Características sociodemográficas en poblaciones de centros turísticos de rápido crecimiento : Majahual /

    OpenAIRE

    2011-01-01

     tesis que para obtener el grado de Doctor en Geografía, presenta Ana Pricila Sosa Ferreira ; asesor Daniel Hiernaux-Nicolás, Bonnie Lucía Campos Cámara, David Velázquez. ii, 254 páginas : ilustraciones. Doctorado en Geografía UNAM, Facultad de Filosofía y Letras, 2011

  7. Education

    Science.gov (United States)

    2003-01-01

    Frank Sosa, Dept. of the Air Force Col Juan Urbano , Peruvian Army Dr. Francis A’Hearn, Faculty Prof. William Mayall, Faculty COL Mark McGuire...Germany House of Commons, Parliamentary Undersecretary State for Education, England Ministry of Science, Research, and Art , Stuttgart, Germany...markets. Fifty percent of the elementary market is composed of reading and language arts . Mathematics and a combination social sciences/science and

  8. 一种考虑实时约束的数据流卸载技术%Novel Load Shedding Approach for Real-time Data Stream Processing

    Institute of Scientific and Technical Information of China (English)

    王洪亚; 覃志东; 李柏岩; 丛静; 王志军; 杜明

    2010-01-01

    在数据流管理系统中,流数据的高到达速率和进发性等特点会引起系统过载,为此人们提出了各种卸载技术来缓解过载问题.目前几乎所有的卸载技术都使用随机丢弃数据的方法,由于随机丢弃数据策略对数据丢弃过程没有任何控制,这对某些考虑实时约束的数据流管理系统是不适合的.本文认为更为精确的卸载模型,比如文中使用的(m,k)截止期模型,更适合于一类重要的实时数据流事件检测应用.基于(m,k)截止期模型,提出一种新的策略SOSA,该策略一方面提供了可证明的卸载能力,同时也保证了系统的时间约束.为验证SOSA的有效性,设计了一种新的数据流调度算法SOSA-DBP.理论分析与模拟实验证明了SOSA-DBP比现有的算法有更好的性能.

  9. Fetal undernutrition is associated with perinatal sex-dependent alterations in oxidative status.

    Science.gov (United States)

    Rodríguez-Rodríguez, Pilar; de Pablo, Angel Luis López; Condezo-Hoyos, Luis; Martín-Cabrejas, María Angeles; Aguilera, Yolanda; Ruiz-Hurtado, Gema; Gutierrez-Arzapalo, Perla Y; Ramiro-Cortijo, David; Fernández-Alfonso, María Soledad; González, María Del Carmen; Arribas, Silvia M

    2015-12-01

    Intrauterine growth retardation predisposes to hypertension development, known as fetal programming. Females are less susceptible, which has been mainly attributed to estrogen influence. We hypothesize that perinatal differences in oxidative status might also contribute. We studied 21-day-old (prepuberal) and 6-month-old male and female offspring from rats fed ad libitum during gestation (Control) or with 50% of Control daily intake from day 10 to delivery (maternal undernutrition, MUN). We assessed in vivo blood pressure and the following plasma biomarkers of oxidative status: protein carbonyls, thiols, reduced glutathione (GSH), total antioxidant capacity, superoxide anion scavenging activity (SOSA) and catalase activities; we calculated a global score (oxy-score) from them. Estradiol and melatonin concentration was measured in young rats. Prepuberal MUN males were normotensive but already exhibited increased carbonyls and lower thiols, GSH, SOSA and melatonin; oxy-score was significantly lower compared to Control males. Prepuberal MUN females only exhibited reduced SOSA compared to Control females. Adult rats from all experimental groups showed a significant increase in carbonyls and a decrease in antioxidants compared to prepuberal rats; oxy-score was negative in adult rats suggesting the development of a prooxidative status as rat age. Adult MUN males were hypertensive and exhibited the highest increase in carbonyls despite similar or even higher antioxidant levels compared to Controls. Adult MUN females remained normotensive and did not exhibit differences in any of the biomarkers compared to Controls. The better global antioxidant status developed by MUN females during perinatal life could contribute to their protection against hypertension programming.

  10. The dielectronic recombination process in laser-produced Au plasmas

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 程新路; 杨向东

    2003-01-01

    The calculations of the rate coefficients for dielectronic recombination (DR) along the NiI isoelectronic sequence in the ground state Au51+ through Cu-like 3d9nln′f (n, n′=4,5,6) inner-shell excited configurations are performed using the spin-orbit-split array (SOSA) model Resonant and nonresonant radiative stabilizing transitions and decays to autoionizing levels followed by radiative cascades are included. Collisional transitions following electron capture are neglected. The trend of the DR rate coefficients and the ratio of dielectronic satellite lines intensities with the change of the electron temperature are discussed.

  11. Un aporte de Carlos Guastavino y Lima Quintana al mundo de la Nueva Canción argentina Carlos Guastavino and Lima Quintana's contribution to the world of the Argentinean New Song

    Directory of Open Access Journals (Sweden)

    Silvina Luz Mansilla

    2011-06-01

    Full Text Available El artículo se refiere a la canción Hermano compuesta por el músico Carlos Guastavino sobre una poesía de Hamlet Lima Quintana. Dedicada al editor Rómulo Lagos, fue grabada por Mercedes Sosa en 1966. Incluida como pista inicial del disco de la cantante tucumana al cual le dio su nombre, la canción constituye una evidencia de la simpatía del compositor con los postulados centrales del Nuevo Cancionero argentino. El trabajo comprende una aproximación a la temática del poema, el análisis musical de la partitura, la puesta en contexto de las circunstancias de composición y difusión y la descripción de la versión grabada por Mercedes Sosa. Aplicando la noción "mundos del arte" de Howard BECKER (1982, se interpreta la red de personas ligadas a la editorial Lagos como un tejido cooperativo que funcionó con eficacia hasta mediados de la década de 1970. Un esbozo del contexto posterior, signado por la censura, permite inferir algunos factores que incidieron en el quiebre de esa red de colaboraciones. Aunque respecto de Guastavino, se habla aquí de vinculación y no de pertenencia.Study about the song Hermano by Argentinean composer Carlos Guastavino written after a poem by Hamlet Lima Quintana. Dedicated to the editor Rómulo Lagos, the song was recorded by the Argentinean singer Mercedes Sosa in 1966. Included as the first track in that record (to which it gave its name, the song constitutes an evidence of the composer's sympathy with the central postulates of the Argentinean New Song. This paper's perspective integrates the poem's subject, the score's musical analysis, the study of the context concerning with the composition and spreading circumstances and the description of the performance recorded by Mercedes Sosa. Applying the notion of "art worlds" by Howard BECKER (1982, we interpret the persons net connected with Lagos publishing, as a co-operative and interwoven fabric that effectively worked until the mid 1970s. A sketch of

  12. [Popular dentistry in the drug registry of Dr. Manduti].

    Science.gov (United States)

    Zarranz, A

    1998-06-01

    There are here described eight medical preparations of dental use appearing in Manduti's list of prescriptions, attributed to the Portuguese physician Salvador de Sosa Revello y Mandoutt, special person who worked as a physician in several countries of South America in the end of the 18th century. In spite of the fact that his diplomas and professional abilities are of a doubtful authenticity, his list of prescriptions, lacking of scientific value, was edited eleven times up to 1904 and is still of interest for historians.

  13. The Prevalence and Importance of Epithelial Plasticity in Metastatic Prostate Cancer

    Science.gov (United States)

    2014-10-01

    34Cancer#13,ඩV110.൛" De"Gasperi,"R.,"Rocher,"A."B.,"Sosa,"M."A.,"Wearne,"S."L.," Perez ,"G."M.,"Friedrich,"V."L.,"Jr.,"Hof,"P."R.,"and൜" Elder,"G."A...34 Nieto ,"M."A."(2012)."Metastatic"colonization"requires"the"repression"of"the"epithelialV36" mesenchymal"transition"inducer"Prrx1."Cancer"Cell#22,螕V724

  14. Bibliographie

    OpenAIRE

    2014-01-01

    Aguilar Medina José Iñigo, 1980, El hombre y la urbe, la ciudad de Oaxaca, Mexico, Sep/Inah. Aguilar Urbina Luisa, 1988, « Reconstrucción de vecindades en Tepito », dans, Cisneros Sosa Armando (coord.), Rescate y reconstruccion del centro de la ciudad de México, Mexico, Uam-Iztapalapa, p. 66-95. Aguilera Gomez Manuel, 1988, « politica de vivienda popular : Nuevas experiencias para su reformulación », conférence présentée, Seminario : la modernización de las ciudades en México, Mexico, Unam. A...

  15. Environmental Analysis of U.S. Navy Submarine Solid Waste Discharges. Report of Findings

    Science.gov (United States)

    1997-05-01

    although cellulose has the same basic molecular makeup as starch, the BODs of starch is 7 times greater at 0.62 g.g"! (pitter et al., 1990). This...solubilized oil in the leachates and the relatively low toxicity of lubricating oil in general. Lubricating oils do not generally contain toxic low- molecular ...Sosa. Pollution By Solid Wastes Carried By Marine Currents To The Caribbean Coast ofHonduras. Revista De Biologia Tropical, V38 N2, pp. 339-342

  16. Redescripción del canto de anuncio de Gastrotheca gracilis Laurent, 1969 (Anura: Hemiphractidae) y primer registro para el Parque Nacional Campo de Los Alisos, Tucumán, Argentina

    OpenAIRE

    Akmentis, Mauricio S.; Bonduri, Yanina V.; Contreras, Pablo; Francisconi, Luis E.; Massabie, Pedro J.; Santillán, Juan

    2014-01-01

    Gastrotheca gracilis es la especie con distribución más austral de la familia Hemiphractidae y es la rana marsupial de Argentina con mayor número de registros geográficos históricos, desde su localidad tipo en “La Banderita” en el límite entre las provincias de Tucumán y Catamarca (Laurent, 1967), hacia el norte en las serranías del oeste y noreste de Tucumán (Laurent et al., 1986). Las dos poblaciones redescubiertas se encuentran en la Reserva Provincial Los Sosa y en la localidad tipo (Akme...

  17. Pemanfaatan Abu Tandan Kosong Kelapa Sawit Untuk Menurunkan Kandungan Minyak/Lemak BOD Dan COD Dari Limbah Cair Pabrik Kelapa Sawit

    OpenAIRE

    Sari, Riris Duma

    2011-01-01

    An investigation of the utilization of oil palm empty fruit bunch ash to reduce the content of oil/grease, BOD and COD from oil mill effluent. Samples of palm oil mill effluent from wastewater treatment plant of PT Nusantara IV (Persero) oil processing unit sopsa of Padang Lawas district. Samples taken from the last pond will be discharged into the environment. Empty Fruit of Oil Palm Ash taken from the kitchen burning empty fruit bunches PT Nusantara IVB (Persero) units Sosa of Padang Law...

  18. The spatial distribution of injuries in need of surgical intervention in Nepal.

    Science.gov (United States)

    Gupta, Shailvi; Groen, Thomas A; Stewart, Barclay T; Shrestha, Sunil; Spiegel, David A; Nwomeh, Benedict C; Groen, Reinou S; Kushner, Adam L

    2016-05-31

    Geographic information system modelling can accurately represent the geospatial distribution of disease burdens to inform health service delivery. Given the dramatic topography of Nepal and a high prevalence of unmet surgical needs, we explored the consequences of topography on the prevalence of surgical conditions. The Nepalese Surgeons OverSeas Assessment of Surgical Need (SOSAS) is a validated, countrywide, cluster randomised survey that assesses surgical need in lowand middle-income countries; it was performed in Nepal in 2014. Data on conditions potentially affected by topography (e.g. fractures, hernias, injuries, burns) were extracted from the database. A national digital elevation model was used to determine altitude, aspect, slope steepness and curvature of the SOSAS survey sites. Forward stepwise linear regression was performed with prevalence of each surgical condition as the response variable and topographic data as explanatory variables. The highest correlation coefficient was for models predicting hernias and fractures, both explaining 21% of the variance. The model fitted to death due to fall would become significant when an outlier was excluded (Pmodel to burn injury (stepwise regression) without any explanatory variables. Other models trended towards a correlation, but did not have sufficient power to detect a difference. This study identified slight correlation between elevation and the prevalence of hernias and fall injuries. Further investigation on the effects of topography and geography on surgical conditions is needed to help determine if the data would be useful for directing allocation of surgical resources.

  19. Ground-Water Quality Data in the Southern Sierra Study Unit, 2006 - Results from the California GAMA Program

    Science.gov (United States)

    Fram, Miranda S.; Belitz, Kenneth

    2007-01-01

    Ground-water quality in the approximately 1,800 square-mile Southern Sierra study unit (SOSA) was investigated in June 2006 as part of the Statewide Basin Assessment Project of the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The GAMA Statewide Basin Assessment Project was developed in response to the Groundwater Quality Monitoring Act of 2001 and is being conducted by the U.S. Geological Survey (USGS) in cooperation with the California State Water Resources Control Board (SWRCB). The Southern Sierra study was designed to provide a spatially unbiased assessment of raw ground-water quality within SOSA, as well as a statistically consistent basis for comparing water quality throughout California. Samples were collected from fifty wells in Kern and Tulare Counties. Thirty-five of the wells were selected using a randomized grid-based method to provide statistical representation of the study area, and fifteen were selected to evaluate changes in water chemistry along ground-water flow paths. The ground-water samples were analyzed for a large number of synthetic organic constituents [volatile organic compounds (VOCs), pesticides and pesticide degradates, pharmaceutical compounds, and wastewater-indicator compounds], constituents of special interest [perchlorate, N-nitrosodimethylamine (NDMA), and 1,2,3-trichloropropane (1,2,3-TCP)], naturally occurring inorganic constituents [nutrients, major and minor ions, and trace elements], radioactive constituents, and microbial indicators. Naturally occurring isotopes [tritium, and carbon-14, and stable isotopes of hydrogen and oxygen in water], and dissolved noble gases also were measured to help identify the source and age of the sampled ground water. Quality-control samples (blanks, replicates, and samples for matrix spikes) were collected for approximately one-eighth of the wells, and the results for these samples were used to evaluate the quality of the data for the ground-water samples. Assessment of the

  20. Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide

    Directory of Open Access Journals (Sweden)

    Kanayama I

    2014-07-01

    Full Text Available Izumi Kanayama,1 Hirofumi Miyaji,1 Hiroko Takita,2 Erika Nishida,1 Maiko Tsuji,3 Bunshi Fugetsu,4,5 Ling Sun,4,5 Kana Inoue,1 Asako Ibara,1 Tsukasa Akasaka,6 Tsutomu Sugaya,1 Masamitsu Kawanami1 1Department of Periodontology and Endodontology, 2Support Section for Education and Research, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan; 3Mitsubishi Gas Chemical Company, Inc., Tokyo, Japan; 4Division of Frontier Research, Research Department, Creative Research Institution Sousei, 5Graduate School of Environmental Science, 6Department of Biomedical, Dental Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan Background: Graphene oxide (GO is a single layer carbon sheet with a thickness of less than 1 nm. GO has good dispersibility due to surface modifications with numerous functional groups. Reduced graphene oxide (RGO is produced via the reduction of GO, and has lower dispersibility. We examined the bioactivity of GO and RGO films, and collagen scaffolds coated with GO and RGO. Methods: GO and RGO films were fabricated on a culture dish. Some GO films were chemically reduced using either ascorbic acid or sodium hydrosulfite solution, resulting in preparation of RGO films. The biological properties of each film were evaluated by scanning electron microscopy (SEM, atomic force microscopy, calcium adsorption tests, and MC3T3-E1 cell seeding. Subsequently, GO- and RGO-coated collagen scaffolds were prepared and characterized by SEM and compression tests. Each scaffold was implanted into subcutaneous tissue on the backs of rats. Measurements of DNA content and cell ingrowth areas of implanted scaffolds were performed 10 days post-surgery.Results: The results show that GO and RGO possess different biological properties. Calcium adsorption and alkaline phosphatase activity were strongly enhanced by RGO, suggesting that RGO is effective for osteogenic differentiation. SEM showed that

  1. Interaction between subinterface cracks and interface in metal/piezoelectric ceramic bimaterials

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    [1]Pak,Y.E.,Crack extension force in a piezoelectric material,ASME Journal of Applied Mechanics,1990,57: 647.[2]Sosa,H.,Pak,Y.E.,Three-dimensional eigenfunction analysis of a crack in a piezoelectric material,International Journal of Solids and Structures,1990,26: 1.[3]Sosa,H.,Plane problems in piezoelectric media with defects,International Journal of Solids and Structures,1991,28: 491.[4]Sosa,H.,On the fracture mechanics of piezoelectric solids,International Journal of Solids and Structures,1992,29: 2613.[5]Park,S.B.,Sun,C.T.,Fracture criteria for piezoelectric ceramics,Journal of the American Ceramic Society,1995,78: 1475.[6]Park,S.B.,Sun,C.T.,Effect of electric fields on fracture of piezoelectric ceramics,International Journal of Fracture,1995,70: 203.[7]Suo,Z.,Kuo,C.M.,Barnett,D.M.et al.,Fracture mechanics for piezoelectric ceramics,Journal Mechanics and Physics of Solids,1992,40: 739.[8]Han,J.J.,Chen,Y.H.,Multiple parallel cracks interaction problem in piezoelectric ceramics,International Journal of Solids and Structures,1999,36: 3375-3390.[9]Suo,Z.,Singularities,interfaces and cracks in dissimilar anisotropic media,Proc.R.Soc.Lond.,1990,A 427: 331.[10]Horii,H.,Nemat-Nasser,S.,Elastic fields of interacting inhomogeneities,International Journal of Solids and Structures,1985,21: 731.[11]Budiansky,B.,Rice,J.R.,Conservation laws and energy-release rates,ASME J.of Appl.Mech.,1973,40: 201.[12]Zhao,L.G.,Chen,Y.H.,Future investigation of subinterface cracks,Archive of Applied Mechanics,1997,67: 393.[13]Chen,Y.H.,Hasebe,N.,A consistency check for strongly interacting multiple crack problem in isotropic,anisotropic,and bimaterial solids,International Journal of Fracture,1998,90: 251.

  2. «Homeland». A Monologue performed in the theatre of the city of Cadiz (19 March 1812. Edition, introduction and notes

    Directory of Open Access Journals (Sweden)

    María RODRÍGUEZ GUTIÉRREZ

    2013-03-01

    Full Text Available This play we have edited was performed to celebrate the promulgation of the Constitution on 19 March 1812 at the Teatro Principal in Cadiz. The edition includes a preliminary study that outlines the literary and journalistic productions of the author of the play, Luis de Sosa y Tovar, during his stay in Cadiz in the times of the Cortes. It also remarks on the actress who performed in the play, Agustina Torres, the Teatro Principal’s First Lady during the years of the Constitution period. The edition also includes a genre analysis, the content of the monologue and an analysis of the anthem that was the climax of the performance. Likewise, we have tried to provide explanations of its mythological and symbolic allusions, and shed light on certain verses.

  3. 理解信念之谜:弗雷格、克里普克、索萨

    Institute of Scientific and Technical Information of China (English)

    梅剑华

    2013-01-01

    我们试图对克里普克《信念之谜》(1979)一文做出阐释、反驳及回应,尤其说明对信念之谜的一种弗雷格式理解并不成立(见索萨(David Sosa)《信念之谜的意蕴》,1996),因为弗雷格式的意义同样导致信念之谜.我们试图捍卫克里普克的一个基本结论:信念之谜并不仅仅是关于名字的谜,而是涉及我们复杂的认知状态.

  4. 类锌金离子的双电子复合过程研究

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 冯晨旭; 张茹

    2007-01-01

    在自旋轨道劈裂阵模型(SOSA)下,理论计算出类锌Au49+的双电子复合速率系数,得出其在电子温度 0.02 keV~5.0 keV范围内的变化规律,分析不同离化度离子的能级特征,及影响双电子复合速率系数的主要因素是相应的中间自电离态旁观电子主量子数、旁观电子角动量和电离能,这为实现等离子体的诊断提供了重要的参数.

  5. 类镍Dy38+离子的双电子复合速率研究%The dielectronic recombination coefficients of Ni-like Dy38+ ions

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 程新路; 杨向东; 朱俊

    2002-01-01

    在自旋轨道劈裂阵模型(SOSA)下,通过类铜组态3d9nln′l′(n′=4,5,6; l′=s,p,d),理论计算出类镍Dy38+的双电子复合速率系数,得出其在电子温度0.02-5.0keV范围内的变化规律,分析了不同离化度离子的能级特征,并分析了影响双电子复合速率系数的主要因素是相应的中间自电离态旁观电子主量子数、旁观电子角动量和电离能,这为实现等离子体的诊断提供了重要的参量.

  6. 类铜Dy37+离子的双电子复合速率研究%The dielectronic recombination coefficients of Cu-like Dy37+ ions

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 张茹; 程新路; 杨向东

    2004-01-01

    在自旋轨道劈裂阵模型(SOSA)下,通过类锌组态,理论计算出类铜Dy37+的双电子复合速率系数,得出其在电子温度0.02 keV~5.0 keV范围内的变化规律,分析了不同离化度离子的能级特征,并分析了影响双电子复合速率系数的主要因素是相应的中间自电离态旁观电子主量子数、旁观电子角动量和电离能,这为实现等离子体的诊断提供了重要的参数.

  7. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound.

    Science.gov (United States)

    Puhakka, Pia H; Te Moller, Nikae C R; Tanska, Petri; Saarakkala, Simo; Tiitu, Virpi; Korhonen, Rami K; Brommer, Harold; Virén, Tuomas; Jurvelin, Jukka S; Töyräs, Juha

    2016-08-01

    Background and purpose - Arthroscopic estimation of articular cartilage thickness is important for scoring of lesion severity, and measurement of cartilage speed of sound (SOS)-a sensitive index of changes in cartilage composition. We investigated the accuracy of optical coherence tomography (OCT) in measurements of cartilage thickness and determined SOS by combining OCT thickness and ultrasound (US) time-of-flight (TOF) measurements. Material and methods - Cartilage thickness measurements from OCT and microscopy images of 94 equine osteochondral samples were compared. Then, SOS in cartilage was determined using simultaneous OCT thickness and US TOF measurements. SOS was then compared with the compositional, structural, and mechanical properties of cartilage. Results - Measurements of non-calcified cartilage thickness using OCT and microscopy were significantly correlated (ρ = 0.92; p measurement of articular cartilage thickness. Although SOS measurements lacked accuracy in thin equine cartilage, the concept of SOS measurement using OCT appears promising.

  8. Modelling atmospheric OH-reactivity in a boreal forest ecosystem

    DEFF Research Database (Denmark)

    Mogensen, D.; Smolander, S.; Sogachev, Andrey;

    2011-01-01

    We have modelled the total atmospheric OH-reactivity in a boreal forest and investigated the individual contributions from gas phase inorganic species, isoprene, monoterpenes, and methane along with other important VOCs. Daily and seasonal variation in OH-reactivity for the year 2008 was examined...... as well as the vertical OH-reactivity profile. We have used SOSA; a one dimensional vertical chemistry-transport model (Boy et al., 2011a) together with measurements from Hyytiala, SMEAR II station, Southern Finland, conducted in August 2008. Model simulations only account for similar to 30......-50% of the total measured OH sink, and in our opinion, the reason for missing OH-reactivity is due to unmeasured unknown BVOCs, and limitations in our knowledge of atmospheric chemistry including uncertainties in rate constants. Furthermore, we found that the OH-reactivity correlates with both organic...

  9. An Extended SISa Model for Sentiment Contagion

    Directory of Open Access Journals (Sweden)

    Zhifeng Liu

    2014-01-01

    Full Text Available One of the main differences between sentiment and infectious diseases is that the former one has two opposite infectious states: positive (optimistic and negative (pessimistic, while the latter one has not. In this paper, based on the SISa model, we consider this issue and propose a new model of sentiment contagion called the SOSa-SPSa model. The results of both numerical and agent-based simulations show that our model could explain the process of sentiment contagion better than that of Hill et al. (2010. Further analysis shows that both the numbers of optimistic and pessimistic individuals will increase with the probability of spontaneity or contagion and decrease with the probability of recovery. Potential applications of this model in financial market have also been discussed.

  10. Parallel Factor Analysis as an exploratory tool for wavelet transformed event-related EEG

    DEFF Research Database (Denmark)

    Mørup, Morten; Hansen, Lars Kai; Hermann, Cristoph S.;

    2006-01-01

    of frequency transformed multi-channel EEG of channel x frequency x time data. The multi-way decomposition method Parallel Factor (PARAFAC), also named Canonical Decomposition (CANDECOMP), was recently used to decompose the wavelet transformed ongoing EEG of channel x frequency x time (Miwakeichi, F., Martinez......-Montes, E., Valdes-Sosa, P.A., Nishiyama, N., Mizuhara, H., Yamaguchi, Y., 2004. Decomposing EEG data into space-time-frequency components using parallel factor analysis. Neuroimage 22, 1035-1045). In this article, PARAFAC is used for the first time to decompose wavelet transformed event-related EEG given...... of the 3-way array of ANOVA F test values clearly showed the difference of regions of interest across modalities, while the 5-way analysis enabled visualization of both quantitative and qualitative differences. Consequently, PARAFAC is a promising data exploratory tool in the analysis of the wavelets...

  11. Conservación de la Madera

    Directory of Open Access Journals (Sweden)

    Universidad Nacional de Colombia Facultad Nacional de Agronomía

    1941-06-01

    Full Text Available Se ha recomendado utilizar para la conservación de las maderas los bicromatos, por la propiedad que tienen de insolubilizar las gomas y la gelatina después de exposición a la luz. También se pueden conservar las maderas por medio de las sales de hierro, Sumérgense los maderos o tablas, primeramente en un baño de sulfato ferroso al 5%, donde se los tiene algunos días poro que se impregnen bien; uno vez secos, embadúrnaseles con silicato de sosa diluído de 5 grados Baumé. La madera puede conservarse de varias maneras en el presente artículo lo veremos.

  12. Tentativas para promover la industria del jabón en la Galicia setecentista

    Directory of Open Access Journals (Sweden)

    Meijide Pardo, Antonio

    1991-12-01

    Full Text Available Not available.

    Ha sido en el fructífero reinado de Carlos III cuando comienzan a adoptarse firmemente las primeras providencias a fin de impulsar lo más posible la industria nacional del jabón, cuyo principal punto de arranque atañe entonces a las ciudades de Sevilla, Alicante y Elche, con el claro designio de eludir la habitual y masiva introducción del artículo extranjero. Tal decisión política de apoyo oficial a empresarios privados habría de permitir, con inmediatez, la proliferación en diversos puntos de la geografía peninsular de numerosas fábricas de jabón, cuyo gran impulso vióse muy propiciado por la extraordinaria abundancia de aceite, sosa y barrilla.

  13. «Homeland». A Monologue performed in the theatre of the city of Cadiz (19 March 1812. Edition, introduction and notes «La patria». Monólogo representado en el teatro de la ciudad de Cádiz (el 19 de marzo de 1812. Edición, introducción y notas

    Directory of Open Access Journals (Sweden)

    María RODRÍGUEZ GUTIÉRREZ

    2013-03-01

    Full Text Available This play we have edited was performed to celebrate the promulgation of the Constitution on 19 March 1812 at the Teatro Principal in Cadiz. The edition includes a preliminary study that outlines the literary and journalistic productions of the author of the play, Luis de Sosa y Tovar, during his stay in Cadiz in the times of the Cortes. It also remarks on the actress who performed in the play, Agustina Torres, the Teatro Principal’s First Lady during the years of the Constitution period. The edition also includes a genre analysis, the content of the monologue and an analysis of the anthem that was the climax of the performance. Likewise, we have tried to provide explanations of its mythological and symbolic allusions, and shed light on certain verses.Esta pieza teatral que editamos se representó para celebrar la promulgación de la Constitución el 19 de marzo de 1812 en el Teatro Principal de Cádiz. La edición se acompaña de un estudio introductorio que incluye un esbozo de la actividad periodística y literaria de su autor, Luis de Sosa y Tovar, durante su estancia gaditana en los años de Cortes, y unas notas alusivas sobre la actriz que lo interpretó, Agustina Torres, primera dama del Teatro Principal durante el periodo constitucional. También se incluye el análisis del género y contenido del monólogo y se comenta el himno que sirvió de colofón a la representación. En las notas de la edición hemos intentado aclarar alusiones mitológicas y simbólicas y, de igual modo, esclarecer el sentido concreto de algunos versos.

  14. The spatial distribution of injuries in need of surgical intervention in Nepal

    Directory of Open Access Journals (Sweden)

    Shailvi Gupta

    2016-05-01

    Full Text Available Geographic information system modelling can accurately represent the geospatial distribution of disease burdens to inform health service delivery. Given the dramatic topography of Nepal and a high prevalence of unmet surgical needs, we explored the consequences of topography on the prevalence of surgical conditions. The Nepalese Surgeons OverSeas Assessment of Surgical Need (SOSAS is a validated, countrywide, cluster randomised survey that assesses surgical need in lowand middle-income countries; it was performed in Nepal in 2014. Data on conditions potentially affected by topography (e.g. fractures, hernias, injuries, burns were extracted from the database. A national digital elevation model was used to determine altitude, aspect, slope steepness and curvature of the SOSAS survey sites. Forward stepwise linear regression was performed with prevalence of each surgical condition as the response variable and topographic data as explanatory variables. The highest correlation coefficient was for models predicting hernias and fractures, both explaining 21% of the variance. The model fitted to death due to fall would become significant when an outlier was excluded (P<0.001; R2=0.27. Excluding the outlier yielded a better-fitted model to burn injury (stepwise regression without any explanatory variables. Other models trended towards a correlation, but did not have sufficient power to detect a difference. This study identified slight correlation between elevation and the prevalence of hernias and fall injuries. Further investigation on the effects of topography and geography on surgical conditions is needed to help determine if the data would be useful for directing allocation of surgical resources.

  15. COMPETENCIAS COMUNICATIVAS EFICACES MEDIANTE ESTRATEGIAS DE APRENDIZAJE COOPERATIVO

    Directory of Open Access Journals (Sweden)

    Alfonso García Gonzáles

    2012-12-01

    Full Text Available RESUMEN: El aprendizaje cooperativo se plantea como una de las principales medicinas de la educación: el estudiante adopta un papel activo en su proceso de aprendizaje. La cuestión metodológica es trascendental dentro de la universidad: el proyecto de construcción del Espacio Europeo de Educación Superior plantea cambios profundos en el paradigma docente, debiendo cambiar los roles del profesor y del alumno, dentro y fuera del aula. Para reforzar este argumento, se procedió a la aplicación del Cuestionario de Aprendizaje Cooperativo de Arellano, Navarro y Sosa (2007 a los 692 estudiantes matriculados en primero de Grado de Educación Primaria en el curso 2010/2011. La muestra coincidió con el universo de los estudiantes de primer año en el Grado de Educación Primaria, constituida por un 87% de mujeres y con una edad media de 19 años, lo cual permitió obtener un índice de consistencia interna de 0.83 para el instrumento. Los resultados recalcaron la importancia de potenciar el aprendizaje cooperativo en las aulas universitarias, teniendo en cuenta que son pocas las ocasiones en las que puede ponerse en juego. ABSTRACT: Cooperative learning is one of the main medicines in education: the student takes an active role in their own learning process. Methodological issues are very important within university, since the development project of the European Higher Education Area proposes very profound changes in the educational paradigm, changes in the role of teachers and students inside and outside the classroom. To give force to this argument, the implementation of Cooperative Learning Questionnaire Arellano, Navarro and Sosa (2007 was taken to 692 students enrolled in first grade of primary education in 2010-2011. The sample coincides with the universe of freshmen in the Bachelor of Primary Education, comprising 87% of women with a mean age of 19 years, which yielded an index of 0.83 for internal consistency of the instrument. The results

  16. Megamelus bellicus (Hemiptera: Delphacidae: immature stages and biology Megamelus bellicus (Hemiptera: Delphacidae: estados inmaduros y biología

    Directory of Open Access Journals (Sweden)

    Roxana Mariani

    2007-12-01

    Full Text Available The immature stages of Megamelus bellicus Remes Lenicov & Sosa (Hemiptera: Delphacidae are described, keyed and illustrated. The description of each stage was based on 24-h hatched nymphs from the laboratory colony. The main characters that distinguish the various stages are: body size, color, number of tarsomeres, espinulation of the metatibia and number of teeth on the spur; presence of sensoria on antennal pedicel. This insect was reared on pieces of water hyacinth, Eichhornia crassipes (Martius Solms Laubach. Biological data based on lab and field observations show that M. bellicus carries out its biological cycle successfully on Pontederiaceae. One to nine eggs per scar are laid deeply into the aerenquima of the petiole, being most frequent 3-4, less frequent 5, 2 and 6 and rarely 1, 7 and 9. Eulophid wasps Aprostocetus (Ootetrastichus sp, known as eggs parasitoid, was registered and quantified. As M. bellicus occupies the same ecological habitat that M. scutellaris Berg, we highlighted some morphological and biological aspects that allow their differentiation.Se describen e ilustran los estados inmaduros de Megamelus bellicus Remes Lenicov & Sosa (Hemiptera: Delphacidae y se presenta una clave para identificarlos. La descripción de cada estadio se realizó sobre la base de ninfas extraidas 24 horas posteriores a la eclosión, de colonias de laboratorio y criadas sobre trozos de hojas de camalote Eichhornia crassipes (Martius Solms Laubach. Los principales caracteres para distinguir los distintos estadios son: tamaño del cuerpo, color, número de tarsómeros, espinulación de la metatibia y número de dientes del calcar y presencia de sensorios en el pedicelo antenal. Datos biológicos basados en observaciones en el laboratorio y en el campo, muestran que M. bellicus realiza su ciclo biológico exitosamente sobre Pontederiaceae. Los huevos, dispuestos de 1 a 9 por postura, son colocados profundamente en el aerénquima del pecíolo; son m

  17. Soil-Vegetation-Atmosphere Radiative Transfer Model in Microwave Region

    Institute of Scientific and Technical Information of China (English)

    JIA Yuanyuan; LI Zhaoliang

    2008-01-01

    The radiative transfer is one of the significant theories that describe the processes of scattering,emission,and absorption of electromagnetic radiant intensity through scattering medium.It is the basis of the study on the quantitative remote sensing.In this paper,the radiative characteristics of soil,vegetation,and atmosphere were described respectively.The numerical solution of radiative transfer was accomplished by Successive Orders of Scattering (SOS).A radiative transfer model for simulating microwave brightness temperature over land surfaces was constructed,designed,and implemented.Analyzing the database generated from soil-vegetation-atmosphere radiative transfer model under Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) configuration showed that the atmospheric effects on microwave brightness temperature should not be neglected,particularly for higher frequency,and can be parameterized.At the same time,the relationship between the emissivities of the different channels was developed.The study results will promote the development of algorithm to retrieve geophysical parameters from microwave remotely sensed data.

  18. Hürthle cell carcinoma: current perspectives

    Directory of Open Access Journals (Sweden)

    Ahmadi S

    2016-11-01

    Full Text Available Sara Ahmadi,1 Michael Stang,2 Xiaoyin “Sara” Jiang,3 Julie Ann Sosa2,4,5 1Division of Endocrinology, Department of Medicine, 2Section of Endocrine Surgery, Department of Surgery, 3Department of Pathology, Duke University Medical Center, 4Duke Cancer Institute, 5Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA Abstract: Hürthle cell carcinoma (HCC can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI. HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases. Patients with localized iodine-resistant disease who are not candidates for a wait-and-watch approach can be treated with localized therapies. Systemic therapy is reserved for patients with progressive, widely metastatic HCC. Keywords: thyroid cancer, thyroid nodule, follicular cell carcinoma, Hurthle cell lesion, minimally invasive HCC

  19. Gd激光等离子体的双电子复合过程研究%Dielectronic recombination process in laser-produced Gd Plasmas

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 郭爱鹏; 张茹

    2006-01-01

    Dielectronic recombination (DR) coefficients for the ground-state ion of Ni-like Gd have been calculated through Cu-like 3d9nln′f(n,n′=4,5,6) inner-shell excited configurations using the spin-orbit-split array(SOSA) model. Resonant and nonresonant radiative stabilizing transitions and decays to autoionizing levels followed by radiative cascades are included. Collisional transitions following electron capture are neglected. Nonresonant stabilizing transitions are found to enhance DR rates, and may even dominate the process at low electron temperature . The trend of the DR rate coefficients and the ratio of dielectronic satellite lines intensities with the change of the electron temperature are discussed.%在自旋-轨道劈裂阵模型下,通过类铜的内壳层激发组态计算了类镍Gd的双电子复合速率系数,其中考虑了共振和非共振辐射平衡跃迁对自电离能级的影响,而忽略了因碰撞跃迁引起的电子俘获,非共振辐射平衡跃迁在低电子温度条件下主要影响双电子复合过程;本文讨论了双电子复合系数及双电子伴线强度比随电子温度的变化.

  20. 金激光等离子体X射线精细结构谱研究%ANALYSIS OF FINE STRUCTURE OF X-RAY SPECTRA FROM LASER-IRRADIATED GOLD DOT

    Institute of Scientific and Technical Information of China (English)

    杨国洪; 张继彦; 张保汉; 周裕清; 李军

    2000-01-01

    在"星光-Ⅱ"钕玻璃激光装置上,聚焦三倍频激光束于真空室内Au微点靶表面,形成高剥离态热等离子体光源.用Pentaerythritol(PET)(2d=0.8742nm)平晶谱仪,摄录了Au离子在0.3-0.4nm范围内的X射线发射谱.基于相对论性多组态Dirac-Fock程序包,建立了相对论性次组态平均能计算程序,结合自旋-轨道劈裂跃迁系(SOSA)理论,计算了Au离子类Cu至类Ge离子细致带结构谱孤立峰的中心波长和半高全宽.26条3d-nf(n=5,6,7)类Ni至类As离子子组态跃迁形成的孤立峰得到了辨认和归类.此结果在激光等离子体的诊断和高Z元素原子结构计算等方面具有重要的应用价值.

  1. Research Advamce of the Software Architecture of Open Robot Controllers%开放式机器人控制器软件体系结构研究进展

    Institute of Scientific and Technical Information of China (English)

    徐华; 贾培发; 赵雁南

    2003-01-01

    开放性已经成为现代机器人控制器的实现目标之一.NGC(Next Generation Controller)虽是第一个遵循开放系统体系结构标准(SOSAS)的机器人控制器,但未解决动态与非结构化环境中的实时响应问题.混合体系结构的机器人控制器LAAS虽具有一定的可扩展性,但没有深入考虑不同组件/模块间的通讯问题.NEXUS和ORC(Open Robot Controller)是正式提出开放概念的分层结构控制器,具有了开放式系统的管理和通讯机制,并提供了不同的操作接口.但其在开放式控制器的功能实现和系统建模方面仍有不足,所以未来的研究将集中于这两个方面.

  2. 秋季温室螺旋藻光合速率、呼吸速率日动态%DAILY VARIATION OF PHOTOSYNTHETIC RATE AND RESPIRATORY RATE OF SPIRULINA IN GREENHOUSE IN AUTUMN

    Institute of Scientific and Technical Information of China (English)

    巩东辉; 乔辰

    2010-01-01

    以鄂尔多斯高原碱湖的钝顶螺旋藻(S1)和2个引进种(非洲乍得湖钝顶螺旋藻S3、墨西哥Sosa Texcoco湖的极大螺旋藻S4)为实验材料,对秋季温室螺旋藻光合速率、呼吸速率日动态进行了测定.结果表明:在温室中秋季晴天螺旋藻的光合速率日变化由于出现光抑制而呈严重型双峰曲线;多云和阴天螺旋藻的光合速率与光强成正相关,呈单峰曲线;螺旋藻的呼吸速率随藻液温度的升降而升降.全天光合产物的总积累量S1要略高于S3、S4.

  3. SOSA与ROCA评价体系在银行监管中应用的思考

    Institute of Scientific and Technical Information of China (English)

    叶瑛; 胡海龙

    2006-01-01

    SOSA(Strength of Support Assessment)与ROCA(Risk Management、Operational Control、Compliance、Assets Quality)评价体系是美国监管当局评估境内外国银行分行的两大工具.SOSA体系从总行对分行的支持力度角度进行评估,ROCA体系注重对分行自身风险管理和内部控制的评估.两者的结合使用,构成了美国监管当局对外国银行分行实施分类监管的主要依据.本文介绍了两项评价体系的主要内容以及在国外监管实践中的运用,提出将此两项评价体系应用于我国商业银行分行的监管的思路.

  4. Program of energy efficiency of Mexichem Derivados Coatzacoalcos; Programas de eficiencia energetica de Mexichem Derivados Coatzacoalcos

    Energy Technology Data Exchange (ETDEWEB)

    Bulbarela Croda, Ruperto; Arce Vargas, Mauricio [Mexichem Derivados Coatzacoalcos (Mexico)

    2007-07-15

    Mexichem Derivados Coatzacoalcos is a producing company of chlorine, soda, sodium hypochlorite and salt. With the purpose of maintaining and consolidating its competitiveness in the international market and to contribute to the preservation of the environment, in 2004 initiated the Program of energy efficiency whose objectives are: to identify the opportunity areas to diminish the present power indexes, to use efficiently the energy sources of the productive activity of the plant and to promote the saving of energy in the companies of Mexichem. [Spanish] Mexichem Derivados Coatzacoalcos es una empresa productora de cloro, sosa, hipoclorito de sodio y sal. Con el fin de mantener y consolidar su competitividad en el mercado internacional y contribuir a la preservacion del medio ambiente, en 2004 inicio con el Programa de eficiencia energetica cuyos objetivos son: identificar las areas de oportunidad para disminuir los indices energeticos actuales, utilizar eficientemente los energeticos de la actividad productiva de la planta y promover el ahorro de energia en las empresas de Mexichem.

  5. Improvement of GVSRM with Addressing the Interoperability Issues in Global Village

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Mollahoseini Ardakani

    2014-10-01

    Full Text Available In today's globally networked environment, enterprises need collaborating using Information Technology (IT and other tools to succeed in this dynamic and heterogeneous business environment. The Global Village Services Reference Model (GVSRM is a model based on SOSA (Service Oriented Strategies and Architectures ontology for global village services realization. In this model, three architectural abstraction layers have been considered for global village: ‘infrastructure for global village services’, ‘global village services provisioning’, and ‘using global village services’. Despite of relative completeness of this model, one of its obvious shortcomings is lack of attention to the crucial issue of interoperability in the global village. Based on this model, the grid of global village is comprised of VHGs (Virtual Holding Governance. The VHG is a temporary, scalable, dynamic cluster/association comprising of existing or newly service provider organizations which its aim is satisfying the requirements of global village actors through electronic processes. In this paper, we will propose a federated approach for interoperability among the VHGs of the global village and then improve the GVSRM by adding the corresponding interoperability components to it.

  6. Egg parasitoids of Megamelus spp. (Hemiptera: Delphacidae in Argentina

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    Serguei V. TRIAPITSYN

    2010-01-01

    Full Text Available Se revisaron los parasitoides oófagos (Hymenoptera: Eulophidae, Mymaridae, y Platygastridae de Megamelus spp. (Hemiptera: Delphacidae de la Argentina, y se presenta una clave para su identificación. Se describen cuatro especies nuevas: Anagrus (Anagrus empanadus Triapitsyn, sp. nov. (Mymaridae, parasitoide de M. scutellaris Berg que se alimenta de camalote, Eichhornia crassipes (Martius Solms-Laubach; Aprostocetus (Ootetrastichus riverplaticus Triapitsyn, sp. nov. (Eulophidae: Tetrastichinae, parasitoide de M. bellicus Marino de Remes Lenicov & Sosa; A. (Ootetrastichus yerbamatei Triapitsyn, sp. nov. (parasitoide de M. bellicus, M. scutellaris y Megamelus sp., todos de la provincia de Buenos Aires (A. (Ootetrastichus yerbamatei también se encuentra en Formosa; y Parascelio sabcli Triapitsyn, sp. nov. (Platygastridae: Scelioninae, parasitoide de M. scutellaris en Formosa, la asociación con el huésped es tentativa. Se incluyen otros parasitoides oófagos conocidos de Megamelus spp. en la Argentina, tales como Kalopolynema (Kalopolynema poema Triapitsyn & Berezovskiy (Mymaridae, parasitoide de M. scutellaris en Buenos Aires y también Cremastobaeus atratus Loiácono & Mulvani (Platygastridae: Scelioninae, parasitoide de M. scutellaris en Formosa, la asociación con el huésped es tentativa.

  7. Two common and problematic leucochrysine species - Leucochrysa (Leucochrysa) varia (Schneider) and L. (L.) pretiosa (Banks) (Neuroptera, Chrysopidae): redescriptions and synonymies.

    Science.gov (United States)

    Tauber, Catherine A; Sosa, Francisco; Albuquerque, Gilberto S

    2013-01-01

    We dedicate this article to the memory of Sergio de Freitas, FCAV-UNESP, Jaboticabal, São Paulo, Brazil (deceased, 2012). He was an active and enthusiastic Neuropterist and the cherished mentor and friend of Francisco Sosa. Leucochrysa McLachlan is the largest genus in the Chrysopidae, yet it has received relatively little taxonomic attention. We treat two problematic and common Leucochrysa species - Leucochrysa (Leucochrysa) varia (Schneider, 1851) and Leucochrysa (Leucochrysa) pretiosa (Banks, 1910). Both are highly variable in coloration and were described before the systematic importance of chrysopid genitalia was recognized. Recent studies show that these species occur within a large complex of cryptic species and that they have accumulated a number of taxonomic problems. We identify new synonymies for each of the species-for Leucochrysa (Leucochrysa) varia: Leucochrysa (Leucochrysa) ampla (Walker, 1853), Leucochrysa internata (Walker, 1853), and Leucochrysa (Leucochrysa) walkerina Navás, 1913; for Leucochrysa (Leucochrysa) pretiosa: Leucochrysa (Leucochrysa) erminea Banks, 1946. The synonymy of Leucochrysa delicata Navás, 1925 with Leucochrysa (Leucochrysa) pretiosa is stabilized by the designation of a neotype. The following species, which were previously synonymized with Leucochrysa (Leucochrysa) varia or Leucochrysa (Leucochrysa) pretiosa, are reinstated as valid: Leucochrysa (Leucochrysa) phaeocephala Navás, 1929, Leucochrysa (Leucochrysa) angrandi (Navás, 1911), and Leucochrysa (Leucochrysa) variata (Navás, 1913). To help stabilize Leucochrysa taxonomy, lectotypes are designated for Allochrysa pretiosa and Allochrysa variata. Finally, Leucochrysa vegana Navás, 1917 is considered a nomen dubium.

  8. 重度OSAS患者前额叶皮质及岛叶1H-MR波谱研究%A Study of 1H-MR Spectroscopy in the Prefrontal Cortex and Insula of Patients with Severe OSAS

    Institute of Scientific and Technical Information of China (English)

    杨兰英; 朱峰岭; 章其林; 吴艳梅; 汪健文

    2011-01-01

    Objective: To explore the characteristics of proton magnetic resonance spectroscopy(lH-MRS) in the prefrontal cortex and insula of patiens with severe obstructive sleep apnea syndrome(S-OSAS). Methods: 18 patients with S-OSAS and 15 healthy controls (HC)were studied using 1H-MRS to detect the changes of left prefrontal cortex and insula.he ratio of N-acetylaspartate/creatine(NAA/Cr) and choline/creatine (Cho/Cr) was respectively measured in the left prefrontal cortex and insula. Results: As compared with healthy volunteers, the patients with severe OSAS had a significant lower ratio of NAA/Cr in the left prefrontal cortex (1.43± 0.47 vs 1.51± 0.65, P<0.05), left insula (1.34± 0.06 vs 1.45± 0.07, P<0.05), while the patients with severe OSAS patients had a significant increased ratio of Cho/Cr in the left prefrontal cortex (0.90± O.O8vsO.87± 0.07, PO.05), left insula(1.19± 0.13vsl.09± 0.02, PO.05). There was a negative linear correlation between the total cummulative time suffering from S-OSAS and the ratio of NAA/Cr in the left prefrontal cortex, insulation. Conclusions: The data from 1H-MRS study indicate that pathoPhysiological changes may occur in the prefrontal cortex and insula, which suggests the abnormalities of executive function and emotion in patients with S-OSAS. A relationship exits between the S-OSAS metabolic abnormality and total cumulative time suffering from OSAS.%目的:利用氢质子MRS(1H-MRS)探讨重度阻塞性呼吸睡眠暂停综合症(Severe obstructive sleep apnea syndrome,S-OSAS)患者前额叶皮质及岛叶脑代谢产物特征.方法:选择18例S-OSAS患者(S-OSAS组)和15名健康志愿者(HC组)行左侧前额叶皮质及岛叶1H -MRS检查,测量两组左侧前额叶皮质区及岛叶N-乙酰天冬氨酸/肌酸(NAA/Cr)、胆碱/肌酸(Cho/Cr)值.对患S-OSAS累计时间与前额叶皮质及岛叶NAA/Cr作直线相关分析.结果:与正常对照组相比,S-OSAS患者左侧前额叶皮质、岛

  9. Statistical properties of levels and lines in complex spectra

    CERN Document Server

    Pain, Jean-Christophe

    2016-01-01

    We review recent developments of the statistical properties of complex atomic spectra, based on the pioneering work of Claire Bauche-Arnoult and Jacques Bauche. We discuss several improvements of the statistical methods (UTA, SOSA) for the modeling of the lines in a transition array: impact of high-order moments, choice of the distribution (Generalized Gaussian, Normal Inverse Gaussian) and corrections at low temperatures. The second part of the paper concerns general properties of transition arrays, such as propensity rule and generalized J-file sum rule (for E1 or E2 lines), emphasizing the particular role of the G1 exchange Slater integral. The statistical modeling introduced by J. Bauche and C. Bauche-Arnoult for the distribution of the M values (projection of total angular momentum J) in an electron configuration, written P(M), was extended in order to account for configurations with a high-l spectator and a new analytical formula for the evaluation of the number of E1 lines with a wider range of applica...

  10. El calendario como método de recolección de datos demográficos

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    Doris Sosa Jara

    2014-01-01

    Full Text Available Los estudios con diseño experimental son una rareza en las ciencias sociales. Ello a pesar de ser el medio idóneo para probar hipótesis o evacuar preguntas científicas de relaciones causa-efecto. La monografía “El calendario como método de recolección de datos demográficos” reimpresa en este número de la revista es un raro ejemplo de estudio experimental para determinar las ventajas y desventajas de este método de recolección de datos retrospectivos e historias de vida. El estudio demuestra la mejora en la calidad de ciertos datos con el uso del calendario, como por ejemplo un aumento de 37% en la proporción de abortos reportados en el calendario en comparación con el cuestionario tradicional. Pero, sobre todo, el estudio subraya la importancia, factibilidad y costo razonable de este tipo de diseños experimentales para poner a prueba métodos alternativos de recolección de información que permitan mejorar la calidad del dato.La monografía fue originalmente impresa por la Asociación Demográfica Costarricense en 1988 y una versión ampliada la publicó en inglés la revista Studies in Family Planning, Vol. 23(6, 1992. El experimento tuvo lugar como parte de la “Encuesta Nacional de Fecundidad y Salud, Costa Rica 1986”, llevada a cabo por dicha asociación en colaboración con los Centros para el Control de Enfermedades, de Atlanta, EEUU. La directora de la encuesta y autora del presente estudio fue Doris Sosa Jara, destacada demógrafa costarricense prematuramente fallecida el 15 de setiembre de 2013. La revista Población y Salud en Mesoamérica eligió para reproducir este documento de entre la variada producción de Doris Sosa, como una muestra de rigor científico en un estudio.En los funerales de Doris en el Auditorio de la Facultad de Ciencias Económicas de la Universidad de Costa Rica, facultad de la que hasta hace poco fue Decana durante 8 años, en medio de los discursos y palabras de aprecio, a uno de sus

  11. TIPOLOGI KONFLIK BERBASIS SUMBER DAYA PANGAN DI WILAYAH PERKEBUNAN SAWIT

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    Sumardjo

    2014-12-01

    Full Text Available This research aims: 1 to analyze typology characteristic and conflict mapping in oil palm plantations; 2 to analyze the effectiveness of conflict resolution processes that have taken; 3 to formulate a conflict resolution strategy that is appropriate to the conflict type through collaborative approach base on potential resource and local knowledge. Primary data collected by interviews with local government officials, key figures, and village leaders. Secondary data obtained from village offices, BPS, texbooks, journals, or data from the internet that contains research results related. Data collection techniques used are a combination of the method of triangulation to obtain accurate data. The data collected and processed in a descriptive analysis of quantitative data supporting. Conflict analysis method used in this study is an analysis of the mission and vision conflict phenomena, analyzes aspects of change, stakeholders analysis, perception analysis, analysis of issues, interests analysis, strategy analysis, analysis of engagement, analysis of potential allies, risk analysis, action analysis, and valuation analysis. The results of this study indicate that the conflict in the Sosa, North Sumatera, has come to the level of "tension" or "crisis". Base on study, there are three main issues that people felt in the area around oil palm plantations, covering: issues of land, inadequate farming, the number of unemployment, as well as the limitations of basic facilities in some villages. Third problem is not handled correctly when very likely to trigger conflict, both between citizens and the business community as well as between fellow citizens of the community.

  12. Associative ERP effects with memories of artificial faces.

    Science.gov (United States)

    Olivares, E; Bobes, M A; Aubert, E; Valdes-Sosa, M

    1994-07-01

    A previous study (Valdes-Sosa and Bobes, 1990) described a negative ERP component evoked by mis-matches in a face-feature matching task, using photographs of real faces. This component could be N400 (or an analogue), elicited by associative priming within a non-linguistic domain: that of face structure. To confirm this it is necessary to demonstrate that semantic/linguistic recoding was not a necessary condition in triggering the negativity. This means falsifying what we call the 'priming by proxy' hypothesis, and locating the triggering mis-match within face structure. In this paper subjects studied artificial schematic faces over several sessions, and 1 week later were presented with a face-feature matching task with simultaneous ERP recording. Since no semantic information or verbal labels were available, eliciting a mis-match negativity with these faces contradicts the 'priming by proxy' hypothesis. In a first experiment, in which the subjects learning was controlled through a face familiarity decision task, no significant mis-match negativity was found. However, in a second experiment in which learning was controlled through a forced-choice face-feature match, a significant mis-match negativity was found in the subsequent recording session. This result supports the idea that a component similar to N400 can be elicited by an associative mis-match restricted to the face-structural domain.

  13. Clinical utility of vandetanib in the treatment of patients with advanced medullary thyroid cancer

    Directory of Open Access Journals (Sweden)

    Deshpande H

    2011-12-01

    Full Text Available Hari Deshpande1,3, Vicky Marler3, Julie Ann Sosa2,31Department of Medicine, 2Department of Surgery, Yale University School of Medicine, 3Yale Cancer Center, New Haven, CT, USAAbstract: Vandetanib (ZD6474 became the first systemic agent to be approved for the treatment of metastatic or locally advanced medullary thyroid cancer. It was a proof of principle, because it is an orally bioavailable medication that targets the growth factors felt to be important in the pathogenesis of this disease, ie, the rearranged during transfection proto-oncogene and vascular endothelial growth factor receptor. It was tested initially in two Phase II studies at doses of 100 mg and 300 mg daily. Although activity was seen at both doses, the higher dose was chosen for a randomized, placebo-controlled Phase II study. This trial, which accrued more than 300 patients, showed a statistically significant benefit for the group taking vandetanib compared with those taking placebo medication. Progression-free survival for the vandetanib arm has not been reached, compared with 19 months for the placebo arm. The main toxicity appears to be diarrhea, although some patients experienced significant side effects, including torsades de pointes and sudden cardiac death. Therefore, it is now necessary for practitioners to enroll in a Risk Evaluation Mitigation Strategy before being allowed to prescribe this medication, to reduce the risk of serious side effects occurring.Keywords: ZD6474, medullary thyroid cancer, vandetanib

  14. Critical appraisal of rituximab in the maintenance treatment of advanced follicular lymphoma

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    Aguiar-Bujanda D

    2015-10-01

    Full Text Available David Aguiar-Bujanda, María Jesús Blanco-Sánchez, María Hernández-Sosa, Saray Galván-Ruíz, Samuel Hernández-Sarmiento Department of Medical Oncology, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain Abstract: Rituximab is an IgG1, chimeric monoclonal antibody specifically designed to recognize the CD20 antigen expressed on the surface of normal and malignant B-lymphocytes, from the B-cell precursor to the mature B-cells of the germinal center, and by most neoplasms derived from B-cells. After 2 decades of use, rituximab is firmly positioned in the treatment of follicular lymphoma (FL, both in the front line and in the relapsing disease, improving previous results by including it in classical chemotherapy regimens. However, the pharmacology of rituximab continues to generate controversial issues especially regarding the mechanisms of action in vivo. The contribution of rituximab as a maintenance treatment in FL has been significant progress in the management of this disease without an increase in side effects or a decrease in the quality of life of patients. With the widespread use of rituximab, there are new security alerts and side effects not previously detected in the pivotal trials that clinicians should learn to recognize and manage. In this article, we will review the pharmacokinetics and pharmacodynamics of rituximab, the management issues in the treatment of advanced FL focusing on maintenance rituximab, its long-term efficacy and safety profile, and its effect on the quality of life. Keywords: follicular lymphoma, long-term efficacy, maintenance, rituximab, toxicity

  15. Dielectronic recombination process in laser-produced Xe plasmas%氙激光等离子体的双电子复合过程研究

    Institute of Scientific and Technical Information of China (English)

    焦荣珍; 冯晨旭; 张茹

    2007-01-01

    Dielectronic recombination(DR)coefficients for the ground-state ion of Ni-like Xe have been calculated through Cu-like 3d9nln'f(n,n'=4,5,6)inner-shell excited configurations using the spin-orbit-split array(SOSA)model.Resonant and nonresonant radiative stabilizing transitions and decays to autoionizing levels followed by radiative cacsades are included.Collisional transitions following electron capture are neglected.Nonresonant stabilizing transitions are found to enhance DR rates,and may even dominate the process at low electron temperature.The trend of the DR rate coefficients and the ratio of dielectronic satellite lines intensities with the change of the electron temperature are discussed.%在自旋-轨道劈裂阵模型下,通过类铜的内壳层激发组态计算了类镍氙的双电子复合速率系数,其中考虑了共振和非共振辐射平衡跃迁对自电离能级的影响,而忽略了因碰撞跃迁引起的电子俘获,非共振辐射平衡跃迁在低电子温度条件下主要影响双电子复合过程;本文讨论了双电子复合系数及双电子伴线强度比随电子温度的变化.

  16. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill

    Directory of Open Access Journals (Sweden)

    Maurizio Guida

    2010-08-01

    Full Text Available Maurizio Guida, Giuseppe Bifulco, Attilio Di Spiezio Sardo, Mariamaddalena Scala, Loredana Maria Sosa Fernandez, Carmine NappiDipartimento di Scienze Ostetriche Ginecologiche Urologiche e Medicina della Riproduzione Umana, Università degli Studi “Federico II”, Napoli, Italia Abstract: The aim of this review is to define the role of the combined dienogest (DNG/­estradiol valerate (E2V contraceptive pill, in terms of biochemistry, metabolic and ­pharmacological effects and clinical application as well. E2V is the esterified form of 17β-estradiol (E2, while dienogest is a fourth-generation progestin with a partial antiandrogenic effect. The cycle stability is achieved with 2 to 3 mg DNG, supporting contraceptive efficacy. In this new oral contraceptive, E2V is combined with DNG in a four-phasic dose regimen (the first two tablets contain 3 mg E2V; the next five tablets include 2 mg E2V + 2 mg DNG, followed by 17 tablets with 2 mg E2V + 3 mg DNG; followed by two tablets with 1 mg E2V only, and finally two placebo tablets. Duration and intensity of scheduled withdrawal bleeding are lower with this ­contraceptive pill, whereas the incidence and the intensity of intra-cyclic bleeding are similar to the other oral contraceptive. With this new pill the levels of high density lipoprotein increased, while the levels of prothrombin fragment 1 + 2 and D-dimer remained relatively unchanged; the levels of sex hormone binding globulin, cortisol binding globulin, thyroxine binding globulin increased. The most frequently reported adverse events are: breast pain, headache, acne, alopecia, migraine, increase of ­bodyweight. The satisfaction rate is about 79.4%.Keywords: estradiol valerate, dienogest, combined oral contraceptive, four-phasic regimen, contraceptive safety

  17. Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer

    Directory of Open Access Journals (Sweden)

    Hari A Deshpande, Scott Gettinger

    2009-06-01

    Full Text Available Hari A Deshpande1, Scott Gettinger1, Julie Ann Sosa21Yale Cancer Center, Department of Medical Oncology, 2Division of Endocrine Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USAIntroduction: Thyroid cancer is a rare disease with an incidence of around 37,000 cases per year. However, its incidence is rising faster than many other cancers and for men this disease ranks highest overall in the rate of increase (2.4% annual increase in cancer deaths. As the number of radioactive iodine-resistant thyroid cancers increases, the need for newer treatments has become more important. Axitinib is one of many new small molecule inhibitors of growth factor receptors that have shown promise in the treatment of many cancers. It targets the vascular endothelial growth factor receptors 1, 2 and 3.Aims: The goal of this article is to review the published evidence for the use of axitinib in the treatment of thyroid cancer and define its therapeutic potential. Evidence review: The major evidence of axitinib activity has appeared in meeting report abstracts. One phase II study has been published. This included patients with any histological type of thyroid cancer that was not amenable to treatment with radioactive iodine. Clinical potential: To date, in phase II clinical studies axitinib has demonstrated antitumor activity in advanced refractory thyroid cancer. As a monotherapy it resulted in a 30% response rate with another 38% of patients having stable disease. Axitinib appears to have a good tolerability profile, with hypertension being the most common grade 3 or greater side effect. Keywords: axitinib, thyroid cancer, vascular endothelial growth factor receptor

  18. Oxidation of SO2 by stabilized Criegee intermediate (sCI radicals as a crucial source for atmospheric sulfuric acid concentrations

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    M. Boy

    2013-04-01

    Full Text Available The effect of increased reaction rates of stabilized Criegee intermediates (sCIs with SO2 to produce sulfuric acid is investigated using data from two different locations, SMEAR II, Hyytiälä, Finland, and Hohenpeissenberg, Germany. Results from MALTE, a zero-dimensional model, show that using previous values for the rate coefficients of sCI + SO2, the model underestimates gas phase H2SO4 by up to a factor of two when compared to measurements. Using the rate coefficients recently calculated by Mauldin et al. (2012 increases sulfuric acid by 30–40%. Increasing the rate coefficient for formaldehyde oxide (CH2OO with SO2 according to the values recommended by Welz et al. (2012 increases the H2SO4 yield by 3–6%. Taken together, these increases lead to the conclusion that, depending on their concentrations, the reaction of stabilized Criegee intermediates with SO2 could contribute as much as 33–46% to atmospheric sulfuric acid gas phase concentrations at ground level. Using the SMEAR II data, results from SOSA, a one-dimensional model, show that the contribution from sCI reactions to sulfuric acid production is most important in the canopy, where the concentrations of organic compounds are the highest, but can have significant effects on sulfuric acid concentrations up to 100 m. The recent findings that the reaction of sCI + SO2 is much faster than previously thought together with these results show that the inclusion of this new oxidation mechanism could be crucial in regional as well as global models.

  19. [Determination of various toxic minerals in spiruline algae of different origins, and evaluation of long-term toxicity in the rat of a lot of spiruline algae of Mexican origin].

    Science.gov (United States)

    Boudène, C; Collas, E; Jenkins, C

    1975-01-01

    A detailed analytical study made on samples of Spirulines algae of various origins showed that these microorganisms may present an important telluric contamination, especially demonstrated by high levels of fluorine and arsenic they contain. A long term animal experimentation has been achieved with Spirula Maxima, obtained from the Sosa Texcoco solar evaporator. A diet contained in total proteins 25 p. 100 of dried atomized algae and was given for 75 weeks to Wistar rats. All along the experiment, the animals submitted to that diet showed no difference with control animals fed with caseine. The increase in weight was comparable for control animals and male experimented animals; a slight decrease in weight has been observed for females fed with algae up to the 30th week. At the end of the experiment, a normal frequency of tumours was noted on experimented animals. The cumulative potentiality of certain mineral toxicants, has been evaluated, when abnormal high levels of them have been detected in the Spirulines samples. The fed animals have been killed at definite times all along the experiment and the metals dosed in the body. Such a cumulative potency has been demonstrated for arsenic. On the contrary, in the case of fluorine, even particular dosages in the femoral bone could not show any significant cumulation of that toxicant, comparing with control animals. In conclusion, the authors have not noted any evident toxicity related to the samples of Spirulines tested in rats, whatever these algae were the only source of proteins in the diet. They hope anyway that the exact origin of contamination of these algaes by these metals will be better known to prevent the variations in the composition of industrial samples of Spirulines according to these metals for instance.

  20. Triarylmethanes, a new class of Cx50 inhibitors

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    SILKE eBODENDIEK

    2012-06-01

    Full Text Available The paucity of specific pharmacological agents has been a major impediment for delineating the roles of gap junction channels formed by connexin proteins in physiology and pathophysiology. Here, we used the selective optimization of side activities (SOSA approach, which has led to the design of high affinity inhibitors of other ion channels, to identify a specific inhibitor for channels formed by Cx50, a connexin subtype that is expressed in the lens. We initially screened a library of common ion channel modulating pharmacophores for their inhibitory effects on Cx50 gap junction channels, and identified four new classes of compounds. The triarlymethane (TRAM clotrimazole was the most potent Cx50 inhibitor and we therefore used it as a template to explore the structure activity relationship (SAR of the TRAMs for Cx50 inhibition. We here describe the design of T122 (N-[(2-methoxyphenyldiphenylmethyl]-1,3-thiazol-2-amine and T136 (N-[(2-iodophenyldiphenylmethyl]-1,3-thiazol-2-amine, which inhibit Cx50 with IC50s of 1.2 µM and 2.4 µM. Both exhibit at least 10-fold selectivity over other connexins as well as major neuronal and cardiac voltage-gated K+ and Na+ channels. The SAR studies also indicated that the TRAM pharmacophore required for connexin inhibition is significantly different from the pharmacophore required for blocking the calcium-activated KCa3.1 channel. Both T122 and T136 selectively inhibited Cx50 gap junction channels in lens epithelial cells, suggesting that they could be used to further explore the role of Cx50 in the lens. In addition, our results indicate that a similar approach may be used to find specific inhibitors of other connexin subtypes.

  1. Triarylmethanes, a New Class of Cx50 Inhibitors

    Science.gov (United States)

    Bodendiek, Silke B.; Rubinos, Clio; Trelles, Maria Pilar; Coleman, Nichole; Jenkins, David Paul; Wulff, Heike; Srinivas, Miduturu

    2012-01-01

    The paucity of specific pharmacological agents has been a major impediment for delineating the roles of gap junction (GJ) channels formed by connexin proteins in physiology and pathophysiology. Here, we used the selective optimization of side activities (SOSA) approach, which has led to the design of high affinity inhibitors of other ion channels, to identify a specific inhibitor for channels formed by Cx50, a connexin subtype that is primarily expressed in the lens. We initially screened a library of common ion channel modulating pharmacophores for their inhibitory effects on Cx50 GJ channels, and identified four new classes of compounds. The triarlymethane (TRAM) clotrimazole was the most potent Cx50 inhibitor and we therefore used it as a template to explore the structure activity relationship (SAR) of the TRAMs for Cx50 inhibition. We describe the design of T122 (N-[(2-methoxyphenyl)diphenylmethyl]-1,3-thiazol-2-amine) and T136 (N-[(2-iodophenyl)diphenylmethyl]-1,3-thiazol-2-amine), which inhibit Cx50 with IC50s of 1.2 and 2.4 μM. Both compounds exhibit at least 10-fold selectivity over other connexins as well as major neuronal and cardiac voltage-gated K+ and Na+ channels. The SAR studies also indicated that the TRAM pharmacophore required for connexin inhibition is significantly different from the pharmacophore required for blocking the calcium-activated KCa3.1 channel. Both T122 and T136 selectively inhibited Cx50 GJ channels in lens epithelial cells, suggesting that they could be used to further explore the role of Cx50 in the lens. In addition, our results indicate that a similar approach may be used to find specific inhibitors of other connexin subtypes. PMID:22685432

  2. A photometric search for activity among asteroids and Centaurs

    Science.gov (United States)

    Sosa Oyarzabal, A.; Mammana, L.; Fernández, J. A.

    2014-07-01

    We present the first results of a long-term observational campaign focused on the detection of activity in selected asteroids and centaurs. Our observational targets are near-Earth asteroids in cometary orbits (cf. [2]), the so called ''main-belt comets'' or ''active asteroids'' (well-known objects as well as potential candidates), and bright centaurs with good orbits, all close to their perihelion passages. In those objects with a former detection of activity, our aim is to contribute to a better physical knowledge of them, and determine, for instance, if the observed activity is transient or permanent. To achieve our goals, we analyzed CCD-filtered images of each observable target acquired with the 2.15-m telescope ''Jorge Sahade'' at CASLEO (San Juan, Argentina), during two runs of three consecutive nights each (during August 2013 and January 2014, respectively). Our study will be completed by future runs with the same instrumentation already assigned to our campaign. As preliminary results, we observed activity in the main-belt comets P/2013 P5 (PANSTARRS) and 133P/(7968) Elst-Pizarro. We also observed the main-belt comet (596) Scheila, which showed an unequivocally stellar appearance. We observed the main-belt comet candidate (3646) Aduatiques (cf. [1]), and noticed in this object a curious feature whose connection to some kind of activity is not well determined yet. We also observed the near-Earth asteroid in cometary orbit 2006 XL_5 (cf. [3]), and the centaurs (281371) 2008 FC_{76}, (332685) 2009 HH_{36}), (382004) 2010 RM_{64}, 2010 XZ_{78}, and 2011 UR_{402}. We have not detected activity in these objects, but an improved analysis is still in progress. %Corresponding author: Andrea Sosa (asosa@fisica.edu.uy)

  3. 夏季温室螺(节)旋藻光合及呼吸速率日动态变化规律%Daily variation of photosynthetic rate and respiratory rate of Spirulina(Arthrospira)in greenhouse in summer

    Institute of Scientific and Technical Information of China (English)

    巩东辉; 张少英; 乔辰; 刘华

    2010-01-01

    对夏季温室培养的鄂尔多斯高原碱湖的钝顶螺(节)旋藻(代号S1)和两个引进螺旋藻种(非洲乍得湖钝顶螺(节)旋藻(代号S3)、墨西哥Sosa Texcoco湖的极大螺(节)旋藻(代号S4)的光合速率、呼吸速率日动态变化规律进行了比较研究.结果表明:(1)在夏季晴天,温室中螺旋藻的光合速率日变化由于出现光抑制而呈双峰曲线,峰值分别出现在10:00时和12:00时;在夏季的多云和阴天状态下,温室中螺旋藻的光合速率日变化规律为单峰曲线.在不同天气状态下螺旋藻呼吸速率的日变化幅度较小.(2)3个螺旋藻样品的光合作用和环境因子分析显示,光强与螺旋藻光合速率之间在"午睡"情况下,呈显著负相关,在"非午睡"情况下,二者呈显著正相关(P<0.05);螺旋藻的呼吸速率随藻液温度的升降而升降,呼吸速率值S4S3S1.(3)3个样品光合产物的日积累量为晴天多云阴天.

  4. The Effect of Calcium and Boron Concentration in Culture Medium on Root Development and Flower Quality of Cut Rose%栽培基质中钙硼浓度对切花月季根系发育及切花质量的影响

    Institute of Scientific and Technical Information of China (English)

    谢庆华; 官会林; 张云峰; 严胜柒

    2008-01-01

    以切花月季"红衣主教"(Sosa hybrida Tea cv.Kardinal/Rosa maltiflora)为供试材料,研究栽培基质中钙、硼浓度对其根系及植株生长发育的影响.结果表明:Ca2+浓度由1.2 g/L增加至2.5 g/L,根重、根体积、根吸收面积、根活跃进吸收面积分别增加15.7%、21.6%、20.1%、21.4%;Ca2+浓度由2.5 g/L增加至3.8 g/L,相应指标分别增加7.5%、10.3%、10.5%、9.1%.B的浓度对相关指标的影响相对复杂,B的促进作用仅在Ca2+充分的条件下才发挥作用.试验同时表明:提高基质中的Ca2+、B浓度,对提高植株及各器官的鲜重均有明显作用.Ca2+含量的测定表明,植株吸收钙的大部分转移至地上部分,而地下部分仅保留少量的吸收钙,Ca2+在月季植株中具有较强的移动性.Ca2+、硼浓度对切花月季的枝长影响不大,而对花枝重量、花杯高度、花杯直径及瓶插寿命,随着钙浓度的提高均有不同程度的提高,特别作为在生产上的极为重要的指标一花杯高度、花杯直径最为明显.

  5. SOS支持下的年报文本事件获取、管理与可视化∗%Access,management and visualization of the annual report text event based on SOS

    Institute of Scientific and Technical Information of China (English)

    杜腾飞; 毛建华; 刘学锋

    2016-01-01

    In order to meet the user’s demand for the annual report text event,a new scheme to access,manage and isualize the annual report text event.Based on SOS,a map application is designed and developed to get the text information of the enterprise virtual sensor.The application mainly includes:Get the text event by DOM tree, enterprise virtual sensor,Standardized management text event and the visualization of text event.By this application, the annual report information which user is interested in can be checked by the type of the annual report text event, displayed on the map,and user compares with the text events in the same industry.The results show that this scheme can get the various information of the annual report text event and it has the feasibility and practicality.%为满足用户对年报文本事件的获取需求,结合传感器网络提出了一种传感器观测服务(sensor observation service,SOS)支持下的年报文本事件获取、管理与可视化方案。该方案基于 SOS平台,设计和实现一种地图终端获取企业虚拟传感器文本信息的应用,主要包括:以DOM树获取文本事件、企业虚拟传感器、标准化管理文本事件、可视化文本事件。通过该应用,实现以年报文本事件类型查看用户感兴趣的年报信息,并以图形化方式显示,方便用户进行同行业对比。结果表明,此方案能够在地图终端获取年报的多种文本事件信息,具有可行性与实用性。

  6. Ablation and optical third-order nonlinearities in Ag nanoparticles

    Directory of Open Access Journals (Sweden)

    Carlos Torres-Torres

    2010-11-01

    Full Text Available Carlos Torres-Torres1, Néstor Peréa-López2, Jorge Alejandro Reyes-Esqueda3, Luis Rodríguez-Fernández3, Alejandro Crespo-Sosa3, Juan Carlos Cheang-Wong3, Alicia Oliver31Section of Graduate Studies and Research, School of Mechanical and Electrical Engineering, National Polytechnic Institute, Zacatenco, Distrito Federal, Mexico; 2Laboratory for Nanoscience and Nanotechnology Research and Advanced Materials Department, IPICYT, Camino a la Presa San Jose, San Luis Potosi, Mexico; 3Instituto de Física, Universidad Nacional Autónoma de México, A.P. 20-364, México, D.F. 01000, MéxicoAbstract: The optical damage associated with high intensity laser excitation of silver nanoparticles (NPs was studied. In order to investigate the mechanisms of optical nonlinearity of a nanocomposite and their relation with its ablation threshold, a high-purity silica sample implanted with Ag ions was exposed to different nanosecond and picosecond laser irradiations. The magnitude and sign of picosecond refractive and absorptive nonlinearities were measured near and far from the surface plasmon resonance (SPR of the Ag NPs with a self-diffraction technique. Saturable optical absorption and electronic polarization related to self-focusing were identified. Linear absorption is the main process involved in nanosecond laser ablation, but nonlinearities are important for ultrashort picosecond pulses when the absorptive process become significantly dependent on the irradiance. We estimated that near the resonance, picosecond intraband transitions allow an expanded distribution of energy among the NPs, in comparison to the energy distribution resulting in a case of far from resonance, when the most important absorption takes place in silica. We measured important differences in the ablation threshold and we estimated that the high selectiveness of the SPR of Ag NPs as well as their corresponding optical nonlinearities can be strongly significant for laser

  7. Optimización del Proceso de Remoción de Metales Pesados de Agua Residual de la Industria Galvánica por Precipitación Química Optimization of the Removal Processs of Heavy Metals from Raw Water of Galvanic Industry by Chemical Precipitation

    Directory of Open Access Journals (Sweden)

    Eduardo Soto

    2006-01-01

    Full Text Available Se han estudiado las condiciones óptimas requeridas para remover metales pesados del agua residual de una industria galvánica, que contiene cromo (435 mg/L, zinc (720 mg/L, hierro (168 mg/L y níquel (24 mg/L. Se usó agua preparada en el laboratorio (agua sintética y agua de la industria misma (agua cruda. El tratamiento se hizo mediante precipitación química, usando sosa para ajustar el pH y cloruro férrico como aditivo coagulante en un equipo de prueba de jarras. Las condiciones óptimas encontradas usando el agua sintética fueron: 7 minutos para el tiempo de floculación, 18 rpm para la velocidad de agitación y 11.8 mL para la dosis de coagulante. Para el agua cruda fueron: 9.5 minutos para el tiempo de floculación, 30 rpm para la velocidad de agitación y 5.2 mL para la dosis de coagulante. Las condiciones de tratamiento fueron diferentes para el agua residual cruda, ya que el agua residual cruda contiene otros contaminantes, los cuales sobrecargan la superficie coloidal, esto afecta el proceso de floculaciónThe aim of this research was to obtain the optimum conditions to remove heavy metals from wastewaters of the galvanic industry, which contain chromium (435 mg/L, zinc (720 mg/L, iron (168 mg/L and nickel (24 mg/L. The treatment was made by chemical precipitation using caustic soda to set pH and ferric chloride like coagulant aid in jar test. The responses to optimize are: flocculation time, stirring speed and coagulant dose. The optimum conditions to remove heavy metals from synthetic wastewater was, flocculation time: 7 minutes, stirring speed: 18 rpm, coagulant dose: 11.8 mL and flocculation time: 9.5 minutes,stirring speed: 30 rpm, coagulant dose: 5.2 mL for raw wastewater. The treatment conditions were different for the raw wastewater because the raw wastewater contains other pollutants which over charge the colloidal surface and affects the flocculation processes

  8. A superoxide anion-scavenger, 1,3-selenazolidin-4-one suppresses serum deprivation-induced apoptosis in PC12 cells by activating MAP kinase

    Energy Technology Data Exchange (ETDEWEB)

    Nishina, Atsuyoshi, E-mail: nishina@yone.ac.jp [Yonezawa Women' s Junior College, 6-15-1 Tohrimachi, Yonezawa, Yamagata 992-0025 (Japan); Kimura, Hirokazu; Kozawa, Kunihisa [Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki, Maebashi, Gunma 371-0052 (Japan); Sommen, Geoffroy [Lonza Braine SA, Chaussee de Tubize 297, B-1420 Braine l' Alleud (Belgium); Nakamura, Takao [Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585 (Japan); Heimgartner, Heinz [University of Zuerich, Institut of Organic Chemistry, Winterthurerstrasse 190, CH-8057 Zuerich (Switzerland); Koketsu, Mamoru [Department of Materials Science and Technology, Faculty of Engineering, Gifu University, Gifu 501-1193 (Japan); Furukawa, Shoei [Laboratory of Molecular Biology, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585 (Japan)

    2011-12-15

    study their possible applications. Black-Right-Pointing-Pointer Among new compounds, compound b showed the strongest SOSA. Black-Right-Pointing-Pointer Compound b suppressed serum deprivation-induced apoptosis in PC12 cells. Black-Right-Pointing-Pointer Compound b suppressed apoptosis by promoting the activation of MAP kinase.

  9. Compensatory lengthening in the Spanish of Havana, Cuba: Acoustic analyses of word-internal, post-nuclear /l/ and /r/

    Science.gov (United States)

    Carlson, Kristin M.

    Given the geographic, demographic, and historical importance of Cuba vis-a-vis the dissemination of language and culture throughout the Hispanic Caribbean, one would naturally anticipate a larger corpus of scientifically-noteworthy linguistic publications on Cuban Spanish, which is far from the actual case. Moreover, the gemination of an onset positionally subsequent to the deletion of a syllable-final liquid (generally termed liquid gemination in the literature) has been repeatedly claimed yet remarkably unsubstantiated as a pervasive characteristic of Cuban Spanish, particularly of the western dialect region (cf. Alfaraz (2000, 2007, 2008), Casanellas and Alamo (1985), Choy Lopez (1985, 1988, 1989), Costa Sanchez (1987), Darias Concepcion (2001, 2005), Dohotaru (2002, 2007), Figueroa Esteva and Dohotaru (1994), Garcia Perez (2006), Garcia Riveron (1991), Haden and Matluck (1973, 1974, 1977), Isbǎsescu (1965, 1968), Lamb (1968), Levina (1970), Montero Bernal (1990, 2002, 2007a, b), Ringer Uber (1986), Ruiz Hernandez (1978), Sosa (1974), Terrell (1976), Trista and Valdes (1978), Valdes Acosta (1980), and Vera Riveron (2000)). As a result, in the interest of supplementing all antecedent work concerning the allophony of final liquids as well as affording a more descriptively-precise account of the allophony of word-internal, post-nuclear /l/ and /[Special character omitted]/ in Cuban Spanish in addition to expressly addressing the need for empirical data-collection and analysis processes, the present investigation was specifically designed and implemented to acoustically investigate the phenomenon of gemination as it is purported to occur in the Spanish of the region of Havana, Cuba: more specifically, (1) to acoustically examine the qualitative and quantitative patternings of post-nuclear /l/ and /[Special character omitted]/ within the word; and (2) to statistically evaluate the relationship between gemination and eight independent variables: gender, age group

  10. Estudio Químico, Micrográfico y Morfológico del Ricinus communis L., y su Aplicación en Pulpa Blanqueable

    Directory of Open Access Journals (Sweden)

    Teófilo Escoto García

    2014-01-01

    Full Text Available México posee una gran gama de especies vegetales no maderables o arbustivos, de los cuales se sabe muy poco, y para el caso del Ricinus communis L., existen trabajos sobre el uso de la semilla en biocombustibles y en la obtención de celulosa a partir del tallo. Con estos antecedentes se recolectó un espécimen de Ricinus communis , se descortezó y astilló para llevar a cabo los análisis de composición química, micrográfico y morfológico del tejido leñoso; aplicando además un proceso químico a la sosa para la obtención de celulosa blanqueable mediante secuencia OD/OP/D, evaluando las propiedades de resistencia fisicomecánica y viscosidad, así como blancura y opacidad. La composición química indica que el contenido en holocelulosa (85.0 % y alfa celulosa (66.3 % se encuentra dentro de los parámetros para papel. El análisis micrográfico reportó la relación de Runkel con un grado II y el análisis morfológico reportó que las fibras tienen una longitud promedio de 1.057 mm y pared de 4.4 m de espesor; con gran posibilidad de producir papel de buena calidad. Las condiciones para la obtención de pulpa se dan en 25 % reactivo, 160 °C, 120 minutos de cocción y 26 minutos de refinación. El tratamiento de blanqueo reportó un grado de blancura de 86.8 % y una viscosidad de 10.7 cp. Concluyendo que de acuerdo a sus componentes químicos, características micrográficas y morfológicas el Ricinus communis L ., técnicamente es viable para su aplicación en pulpa blanqueable.

  11. Formalization of the engineering science discipline - knowledge engineering

    Science.gov (United States)

    Peng, Xiao

    Knowledge is the most precious ingredient facilitating aerospace engineering research and product development activities. Currently, the most common knowledge retention methods are paper-based documents, such as reports, books and journals. However, those media have innate weaknesses. For example, four generations of flying wing aircraft (Horten, Northrop XB-35/YB-49, Boeing BWB and many others) were mostly developed in isolation. The subsequent engineers were not aware of the previous developments, because these projects were documented such which prevented the next generation of engineers to benefit from the previous lessons learned. In this manner, inefficient knowledge retention methods have become a primary obstacle for knowledge transfer from the experienced to the next generation of engineers. In addition, the quality of knowledge itself is a vital criterion; thus, an accurate measure of the quality of 'knowledge' is required. Although qualitative knowledge evaluation criteria have been researched in other disciplines, such as the AAA criterion by Ernest Sosa stemming from the field of philosophy, a quantitative knowledge evaluation criterion needs to be developed which is capable to numerically determine the qualities of knowledge for aerospace engineering research and product development activities. To provide engineers with a high-quality knowledge management tool, the engineering science discipline Knowledge Engineering has been formalized to systematically address knowledge retention issues. This research undertaking formalizes Knowledge Engineering as follows: 1. Categorize knowledge according to its formats and representations for the first time, which serves as the foundation for the subsequent knowledge management function development. 2. Develop an efficiency evaluation criterion for knowledge management by analyzing the characteristics of both knowledge and the parties involved in the knowledge management processes. 3. Propose and develop an

  12. Homenaje a Julieta Quilodrán

    Directory of Open Access Journals (Sweden)

    Viridiana Sosa

    2013-01-01

    Full Text Available El Centro de Estudios Demográficos, Urbanos y Ambientales de El Colegio de México realizó un reconocimiento a la trayectoria de la profesora investigadora Julieta Quilodrán 1 por su destacada labor en la docencia e investigación demográficas durante más de cuatro décadas. Durante el homenaje se hizo un recuento de su sobresaliente desempeño como pro - fesora investigadora en análisis demográfico; se enfatizó que Julieta Quilodrán es pio - nera en la investigación sobre familia y nupcialidad, que ha dedicado cuarenta años a investigar las transformaciones del matrimonio, la familia y la fecundidad en México y América Latina, y que es una referencia en la investigación en la demografía mundial. Además ha formado a un gran número de generaciones de demógrafos, a quienes ha inculcado el rigor en el uso de todas las metodologías del análisis demográfico. También se presentó el libro Parejas conyugales en transformación –del cual Julieta Quilodrán es compiladora–, 2 en el que se documentan desde el punto de vista demográfico los cambios ocurridos en el ámbito de la vida conyugal y familiar a partir de varios enfoques metodológicos cuantitativos, cualitativos y jurídicos. El reconocimiento y la presentación del libro se llevaron a cabo el 23 de abril de 2012 en El Colegio de México. En la ceremonia participaron Teresa Castro, Robert McCaa, Beatriz Figueroa, Viridiana Sosa, Manuel Ordorica y Silvia Giorguli. Por úl - timo, Julieta Quilodrán emitió un breve mensaje de agradecimiento. A continuación presentamos las palabras de quienes intervinieron en el acto, precedidas por una intro - ducción elaborada por Silvia Giorguli, directora del Centro de Estudios Demográficos, Urbanos y Ambientales de El Colegio de México.

  13. Utilization of flavonoid compounds from bark and wood: a review.

    Science.gov (United States)

    Yazaki, Yoshikazu

    2015-03-01

    Flavonoid compounds, which are extracted from bark and wood and used commercially, are flavan 3-ols as monomers and their polymers, which are called "condensed tannins". Reactions of the condensed tannins with formaldehyde are the basis for wood adhesives. In the late 1940s, tannin research for wood adhesives was begun and the world-first commercial use of wattle tannin from black wattle (Acacia mearnsii) bark as wood adhesives occurred in Australia in the 1960s. In addition, wattle tannin-based adhesives were further developed in South Africa and the uses of these adhesives have been continuing to date. The success of wattle tannin in wood adhesives is demonstrated by the collaboration of the ACIAR with the CAF in the early 1990s. Although radiata pine bark (Pinus radiata) could be a useful resource for the production of wood adhesives, three problems prevented its use in this application: low extractive yields from the bark, variable quality of the tannin extracts and excessive viscosity of the formulated tannin adhesives. In order to overcome these problems, various extraction methods have been proposed. Studies on tannin adhesives from bark of other pine species are also described. Furthermore, the use of the tannin in the bark without extraction is described as "bark adhesives" from radiata pine and black wattle. The use of radiata tannin without formaldehyde for moulded wood products is also described. Owing to the strong antioxidant activity of flavonoid compounds, bark extracts from French maritime pine (Pinus pinaster, synonym P. maritima) and radiata pine have been commercialized as nutritional supplements: Pycnogenol and Enzogenol, respectively. The background and the development of Pycnogenol and the basic difference in the preparation processes between Pycnogenol and Enzogenol are described. On the basis of the discovery that the SOSA value for wattle tannin is approximately 10 times that of extracts from pine bark supplements (Pycnogenol and Enzogenol

  14. Characterization of drought patterns through remote sensing over The Chihuahua Desert, Mexico"

    Science.gov (United States)

    Madrigal, J. M.; Lopez, A.; Garatuza, J.

    2013-12-01

    Drought is a phenomenon that has intensified during the last few decades in the arid and semi-arid zones of northern Mexico. In the Chihuahua desert, across Chihuahua, Durango and Coahuila states has caused loss of food sustainability (agriculture, livestock), an increase in human health problems, and detriment of ecosystem services as well as important economic losses. In order to understand this phenomenon, it is necessary to create tools that allow monitoring the territory's spatial heterogeneity and multi-temporality. With this purpose we propose the implementation of a drought model which includes the traditional indexes of climatic drought, such as the Palmer Drought Severity Index PDSI, the Standardized Index of Rainfall SPI, data from meteorological stations and biophysical variations obtained from the MODIS sensors product MOD13 NDVI from 2001 to 2010, as well as biophysical variables characteristic of the environment, such as land use and vegetation coverage, Eco-regions, soil moisture, digital elevation model and irrigate agriculture districts. With the MODIS images, a spatially coherent time series was created analyzing the study area's phenology (TIMESAT) created the Seasonal Greenness (SG) and Start of Season Anomaly (SOSA) for the mentioned nine years. Through this, the annual cycles were established. With a decision tree model, all the previously mentioned proposed variables were integrated. The proposed model produces a general map which characterizes the vegetation condition (extreme drought, severe drought, moderate drought, near normal). Even though different techniques have been proposed on the monitoring of droughts, most of them generate drought indexes with a spatial resolution of 1km (Wardlow, B. et. al 2008; Levent T. et al. 2013). One of the main concerns of researchers on the matter is on improving the spatial information content and on having a better representation of the phenomenon. We use the normalized difference vegetation index

  15. Editorial

    Directory of Open Access Journals (Sweden)

    Carolina Santamaría Ulloa

    2014-01-01

    ón para el monitoreo de los derechos de los adultos mayores de Argentina y Uruguay, basado en el enfoque de los derechos humanos.El quinto artículo científico realiza una evaluación de la energía y los macronutrientes de la alimentación servida a niños y niñas menores de seis años en centros de cuido y hogares comunitarios de la Gran Área Metropolitana de Costa Rica; en él, Zúñiga y Fernández concluyen que la mayoría de los platos servidos a esta población de estudio no cumplen con el aporte de energía recomendado, mientras que el aporte de carbohidratos superó las recomendaciones en todos los centros estudiados.El sexto artículo nos traslada a México; en él, Reyes y Álvarez evalúan los programas de formación de promotores para la prevención y el control de la tuberculosis en la región fronteriza de Chiapas. Las autoras elaboran sus conclusiones en torno a la importancia de la participación comunitaria para definir el problema de la tuberculosis y reflexionar sobre los posibles caminos a seguir. Se demuestra la eficacia de la capacitación de promotores y su utilidad en el proceso de tratamiento de la tuberculosis a nivel comunitario.Nuestra sección de documentos históricos es un homenaje póstumo a la Dra. Doris Sosa Jara, quien fue decana de la Facultad de Ciencias Económicas de la Universidad de Costa Rica por espacio de ocho años, además de activa colaboradora de esta revista. Luis Rosero hace una caracterización del aporte académico de la Dra. Sosa, y nos recuerda su carrera profesional y las cualidades humanas que siempre la caracterizaron.De parte del Comité Editorial de Población y Salud en Mesoamérica, les extendemos las más sinceras gracias a todos los autores por elegirnos como portal electrónico para la publicación de sus estudios académicos e investigaciones, y a los lectores, quienes son los que nos alientan a continuar trabajando para mejorar la calidad de nuestras publicaciones.

  16. VB studies on bonding features of HNCHCN

    Institute of Scientific and Technical Information of China (English)

    LIAO; Xinli(

    2003-01-01

    University Press, 1960, 64-107.[13]Sosa, C., Noga, J., Purvis, G. D. et al., An application of the full CCSDT coupled-cluster method to potential-energy curves-- the CH4→CH3+H dissociation, Chem. Phys. Lett., 1998, 153(2-3): 139-146.[14]Wu, W., Song, L. C., Mo, Y. R. et al., XIAMEN--An ab initio Spin-Free Valence Bond Program, Xiamen: Xiamen University, 1999.[15]Li, Q. M., Fu, X. Y., The topological characteristics of the structures in the vicinity of the transition state of HCN-HNC isomerization, Acta Phys. Chem. Sinica (in Chinese), 1992, 8(6): 724-727.[16]Pau, C. F., Hehre, W. J., Heat of formation of hydrogen isocyanide by ion-cyclotron double-resonance spectroscopy, J. Phys. Chem., 1982, 86(3): 321-322.

  17. Science.gov (United States)

    Benítez Brito, Néstor; Oliva García, José Gregorio; Delgado Brito, Irina; Pereyra-García Castro, Francisca; Suárez Llanos, José Pablo; Leyva González, Francisco Gustavo; Palacio Abizanda, José Enrique

    2016-11-29

    Introducción: la alimentación constituye el pilar fundamental del soporte nutricional de los pacientes hospitalizados. Evaluar el grado de aceptación de la dieta es imprescindible en aras de combatir la desnutrición hospitalaria.Objetivos: a) determinar el grado de satisfacción de los pacientes en relación con las dietas; y b) analizar posibles variables asociadas a un grado de satisfacción mayor (apetito y tipo de dieta).Material y métodos: estudio descriptivo de corte transversal. Se emplea una encuesta de 17 preguntas con datos sociodemográficos, datos cualitativos, así como la valoración general del paciente. Se comparó el grado de satisfacción global en función del apetito y el tipo de dieta (terapéutica vs.basal; con sal vs.sosa) (Test no paramétric o Krustal-Wallis y T-Student para muestras independientes, respectivamente).Resultados: mil cuatrocientos trece pacientes. Edad: 53,9 ± 19 años; 51,3% mujeres. Dieta terapéutica (34,9%). Solo el 39,4% tomó dieta con sal. El 66,8% refirió ingresos previos. La alimentación del hospital para un 43% de pacientes fue ''como esperaba'', mientras que para un 44,1% fue ''mejor de lo que esperaba''. El horario de comidas era adecuado (89,1%) y el tiempo para comer, suficiente (96,4%). En cuanto a las características de la comida servida, consideraron como buenas o muy buenas la misma el porcentaje reflejado: sabor/gusto (56.3%), olor (65,5%), cocinado (69,2%), presentación (80,4%), tamaño de ración (75,9%), calidad (73%), cantidad (77,9%), variedad (67,6%), temperatura (70,4%). La valoración global de la alimentación en una escala de 1 a 10 fue de 6,8 ± 2,3. El apetito se asoció a un aumento significativo de la satisfacción global alimentaria del paciente (p < 0,01). El tipo de dieta o la presencia de sal en la misma no se asociaron a un aumento significativo de la satisfacción con la dieta de los pacientes (p = 0,99 y 0,35, respectivamente).Conclusiones: aunque el grado de satisfacción de

  18. Reflection on a Recent Development of Epistemic Logics%对认知逻辑一个新发展的若干省思

    Institute of Scientific and Technical Information of China (English)

    王文方

    2014-01-01

    当代有关于外在世界的激进怀疑论者常利用知识封闭性原则去论证他们的立场。为了反驳这样的怀疑论,有些学者主张我们应该重新检视知识的标准,以便发现这些怀疑论论证中的问题,特别是知识封闭性原则是否成立的问题。在这些学者中,有两类极为受到重视:一类是主张知识的成立与否只涉及“相关的”可能性是否已被排除的相关选择理论学者,如D. Lewis、F. Dretske、和M. Heller,另一类则是主张知识的成立与否与某些虚拟条件是否为真有关的虚拟论者,如R. Nozick、E. Sosa、和K. DeRose。不幸的是,对于这两类理论的讨论往往流于直觉并因而缺乏逻辑的严谨性。为了弥补这个缺点,W. Holliday最近利用了两种新的形式化语意论去重新模塑上述两类理论,并严格证明了每种理论在知识封闭性问题上的逻辑结果。他的形式化工作和证明带来了极为严格而又丰硕的成果,本论文的主旨便在对Holliday这一个认知逻辑的新发展方向作出若干哲学与逻辑上的省思。%Contemporary skeptics about our knowledge of the external world typically argue for their position by appealling to principles of knowledge closure. To respond to the skeptical challenge, some epistemologists propose that we need to re-examine our crite-rion of knowledge so as to expose problems of these skepticist arguments. This maneu-ver, in particular, has something to do with the issue whether any principle of knowledge closure is plausible or not. One approach of this direction concerns with the“relevant alternatives”proposal. Dretske, Lewis, and Heller are the main advocators. Another approach, advocated by Nozick, Sosa, and DeRose, concerns with whether and how the truth of some subjunctive conditionals is relevant to our attribution of human knowledge. Unfortunately, the two approaches are typically based on mere intuitions and lack logical

  19. Energy saving using solar filters with iron base in windows; Ahorro de energia usando filtros solares con base en hierro en ventanas

    Energy Technology Data Exchange (ETDEWEB)

    Chavez Galan, Jesus

    2003-07-01

    termico generado al interior de las edificaciones por las inadecuadas propiedades de los materiales de construccion, se desarrollaron en este trabajo filtros solares con base en hierro por medio de los cuales se logra un control selectivo de la radiacion solar que se transmite a traves de las ventanas. Estos filtros solares consisten en peliculas delgadas de FeO depositadas sobre sustratos de vidrio cal-sosa (el mas usado en nuestro pais para las edificaciones) de 600x300x3 mm, por medio de la tecnica de sputtering asistida con radiofrecuencia y magnetrones planos, partiendo de un blanco de hierro puro de 127x254 mm y usando un plasma de argon. Para obtener el grado de oxidacion deseado en el hierro, pequenas muestras (45 x 22 mm) fueron sometidas a un proceso de calentamiento en una atmosfera reductora constituida de 50% H{sub 2} + 50% N{sub 2}, durante un periodo de tiempo de 10 minutos a una temperatura de 400 C. Los filtros solares con base en FeO presentan una transmisividad de 30.2% para el intervalo visible del espectro electromagnetico (radiacion con longitud de onda de 380-780 nm), y de 39.9% para el infrarrojo cercano (radiacion con longitud de onda de 780-2500 nm); mientras que su reflectividad es de 17.5 y 19%, para los intervalos visibles e infrarrojo cercano del espectro electromagnetico respectivamente. Se realizo una simulacion, a traves del software Energy 10, del comportamiento energetico de una casa-habitacion cuando utilizan en las ventanas vidrios simples (una lamina) tipo cal-sosa, asi como tambien cuando esta misma edificacion usa en las ventanas los filtros solares con base en FeO desarrollados. Ambos casos se comparan obteniendose asi los posibles ahorros de energia por el uso de dichos filtros solares en las ventanas. Las simulaciones fueron llevadas a cabo para diferentes localidades del pais, obteniendose que los filtros solares con base en FeO desarrollados, permiten ahorros de energia principalmente por concepto de acondicionamiento de aire

  20. Lesson Ⅰ Open Architecture-Developing Tendency of CNC System%第一讲开放式体系结构-数控系统发展的潮流

    Institute of Scientific and Technical Information of China (English)

    王正兵; 任偲

    2002-01-01

    Workstation/Machine Controller)和开放式系统体系结构标准SOSAS(Standards of Open System Architecture for Automatic Systems),首次提出了开放式体系结构的概念.1992年,欧共体开始实施自动化系统控制装置的开放系统体系结构计划OSACA(Open System Architecture for Control Within Automation Systems).经过十多年的发展,开放性一词已经深入人心,并且体现在相关产品中.开放式数控系统成为CNC发展的潮流.

  1. Results of Non-contrast Brain Computed Tomography Scans of 1-18 Year Old Epileptic Children

    Directory of Open Access Journals (Sweden)

    Razieh FALLAH

    2012-09-01

    . Clinicalcorrelates of CT abnormality in generalized childhood epilepsy in India. J Trop Pediatr 1997;43(4:199-203.Aguilar-Rebolledo F, Sosa-Villalobos R, del Castillo- Troncoso C. Should computed axial tomography of theskull be done in all pediatric patients with epilepsy?. BolMed Hosp Infant Mex 1992;49(12:845-50. (in SpanishObajimi MO, Fatunde OJ, Ogunseyinde AO, OmigbodunOO, Atalabi OM, Joel RU. Computed tomography and childhood seizure disorder in Ibadan. West 2004;23(2:167-72.Wammanda RD, Anyiam JO, Hamidu AU, Chom ND,Eseigbe EE. Computerized tomography of children with seizure disorders. Niger J Clin Pract 2009;12(1:25-8.Korff C, Nordli DR Jr. Do generalized tonic-clonic seizures in infancy exist? Neurology 2005, 65:17501753.Vanderver A, Chang T, Kennedy C, et al. MR Imaging forthe diagnosis of cerebral dysplasia in new onset seizuresin children. Ann Neurol 2003,54:S114.

  2. 经皮心包穿刺术进行室性心律失常心外膜标测和消融的应用体会%Application of pericardial puncture for mapping and ablation of ventricular arrhythmias

    Institute of Scientific and Technical Information of China (English)

    薛玉梅; 詹贤章; 廖洪涛; 方咸宏; 魏薇; 刘洋; 廖自立; 邓海; 吴书林

    2015-01-01

    with VA who ac-cepted the subxyphoid pericardial puncture ( Sosa ’ s method ) for epicardial mappings. There were 28 men, 12 women,aged(46±13)years. Sixteen patients suffered from non-ischemic cardiomyopathies(NICM),11 arrhythmo-genic right ventricular cardiomyopathies( ARVC) ,3 ischemic cardiomyopathies( ICM) ,10 idiopathic VA. We ana-lyzed how to minimize the occurrence of complications associated with this technique,and how to rapidly recognize and treat the complications that they encountered. Results The pericardial punctures were done successfully at the first attempt in 25 patients,while in 15 patients the pericardial puncture were done successfully at the second attempt or more. Fifteen pericardial punctures were directed to the anterior wall of the right ventricle,while 25 were directed to the inferior wall. Totally in 35 cases(87. 5%) the ablations were successful,including targets on the epicardium in 15 patients,targets on both the endocardium and the epicardium in 14 patients,targets on the endocardium in 6 patients demonstrated by the combined endocardial and epicardial mappings. The combined en-docardial and epicardial ablation failed in two patients with ventricular tachycardias due to NICM. The ablations in 2 cases with idiopathic premature ventricular contractions were abandoned due to vicinity of coronary arteries. In one patient,the ablation was given up due to coronary artery injured by puncture. Totally 13 patients(32. 5%)suf-fered from complications including a severe one(2. 5%). There were 6 cases(15%)of right ventricular injuries without adverse results. There were 2 cases(5%)of bleeding in pericardial cavities,cured by drainage. The guide-wires entered the pleural cavities in 2 cases(5%),without adverse results. There was one case(2. 5%) of late pericardial tamponade,cured by drainage of 80 ml effusion. There was one case of acute pericardial tamponade due to injury of coronary artery,cured by emergent surgery. Thirty-five(87. 5%) patients