78 FR 17080 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-03-20

... Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation... certain Rolls-Royce Deutschland Ltd & Co KG (RRD) BR700-710 series turbofan engines. This AD requires... applies to Rolls-Royce Deutschland Ltd & Co KG (RRD) BR700-710A1-10 and BR700-710A2-20 turbofan engines...

Present status and perspectives of Co-combustion in German power plants

Energy Technology Data Exchange (ETDEWEB)

Richers, U.; Seifert, H. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Technische Chemie]|[Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Programm Nachhaltigkeit, Energie- und Umwelttechnik; Scheurer, W.; Hein, K.R.G. [Stuttgart Univ. (Germany). Inst. fuer Verfahrenstechnik und Dampfkesselwesen

2002-05-01

Various approaches to the future waste management policy in Germany are currently under discussion. One problem arising in this connection is the suitability of existing furnaces for the co-combustion of waste. The use of sewage treatment sludge in power plants is already being practiced on a technical scale. Co-combustion in power plants is of interest also because of the CO{sub 2} problem, as renewable resources can also be used for this purpose. This article documents the technical status of co-combustion in Germany and the available quantities of selected supplementary fuels. Moreover, experience accumulated in German coal fired power plants in using supplementary fuels is compiled. Future possibilities are assessed. (orig.) [German] Fuer die zukuenftige Ausrichtung der Abfallentsorgung gibt es verschiedene Moeglichkeiten, die in der Bundesrepublik Deutschland diskutiert werden. Eine Fragestellung in diesem Zusammenhang ist die Eignung bestehender Feuerungsanlagen fuer die Mitverbrennung von Abfallstoffen. Der Einsatz von Klaerschlamm in Kraftwerken wird bereits grosstechnisch praktiziert. Die Mitverbrennung in Kraftwerken ist zusaetzlich aufgrund der CO{sub 2}-Problematik von Interesse, denn nachwachsende Rohstoffe eignen sich ebenfalls zur Mitverbrennung. In dieser Arbeit werden der technische Stand der Mitverbrennung in der Bundesrepublik Deutschland und die dort zur Verfuegung stehenden Mengen ausgewaehlter Zusatzbrennstoffe dokumentiert. Ausserdem werden die Erfahrungen aus deutschen Kraftwerken beim Einsatz von Zusatzbrennstoffen zusammengestellt. Die zukuenftigen Moeglichkeiten werden abgeschaetzt. (orig.)

Energy - politics - history. National and international energy politics since 1945; Energie - Politik - Geschichte. Nationale und internationle Energiepolitik seit 1945

Energy Technology Data Exchange (ETDEWEB)

Hohensee, J. [ed.; Salewski, M. [ed.

1993-12-31

All articles focus on historical aspects of the development of energy politics in the Federal Republic of Germany (energy enconomy and industry, hard coal, nuclear energy). Some articles also look at international developments (oil boycott, Saudia Arabias`s oil policies, International Energy Agency). (UA) [Deutsch] Im Vordergrund der Beitraege stehen historische Aspekte der Entwicklung der Energiepolitik in der Bundesrepublik Deutschland (Energiewirtschaft, Steinkohle, Kernenergie), einige Arbeiten werfen auch einen Blick auf internationale Entwicklungen (Oelboykott, Erdoelpolitik Saudi-Arabiens, Internationale Energie-Agentur). (UA)

Auf den Fluren von Ausländerbehörden

Directory of Open Access Journals (Sweden)

Valentin Groebner

2002-01-01

Full Text Available Rezensierte Werke:John Torpey, The Invention of the Passport. Surveillance, Citizenship, and the State, Cambridge: Cambridge University Press 2000, 212 S., ISBN 0-521-63249-8 Andreas Fahrmeir, Citizens and Aliens. Foreigners and the Law in Britain and in the German States 1789–1870, New York und Oxford: Berghahn 2000, 258 S., ISBN 1-57181-717-4 Dieter Gosewinkel, Einbürgern und Ausschließen. Die Nationalisierung der Staatsangehörigkeit vom Deutschen Bund bis zur Bundesrepublik Deutschland, Göttingen: Vandenhoeck & Ruprecht 2001, 472 S., ISBN 3-525-35165-8

78 FR 17075 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-03-20

... Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation... certain Rolls-Royce Deutschland Ltd & Co KG (RRD) Tay 611-8 turbofan engines. This AD requires inspection... (RRD) Tay 611-8 turbofan engines, serial numbers 16245, 16256, 16417, 16418, 16584, 16585, 16639, 16640...

78 FR 35574 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-06-13

... Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation... airworthiness directive (AD) for all Rolls-Royce Deutschland Ltd & Co KG (RRD) model Tay 650-15 turbofan engines... Compliance We estimate that this proposed AD affects 52 Tay turbofan engines installed on airplanes of U.S...

Status report on the use of nuclear energy in the Federal Republic of Germany 2016; Statusbericht zur Kernenergienutzung in der Bundesrepublik Deutschland 2016

Energy Technology Data Exchange (ETDEWEB)

Bredberg, Ines; Hutter, Johann; Kuehn, Kerstin; Niedzwiedz, Katarzyna; Philippczyk, Frank [Bundesamt fuer kerntechnische Entsorgungssicherheit (BFE), Salzgitter (Germany); Thoemmes, Achim [Bundesamt fuer Strahlenschutz, Salzgitter (Germany)

2017-08-15

. Information is provided on the purpose and capacity of nuclear fuel supply and disposal facilities. The approval history and the current operating and approval status are also displayed. In the field of final disposal, the new legal structures, supervision and ongoing projects are described. The information is summarized at the end of the report in tabular form. The report is issued annually in updated form. [German] Am 30.07.2016 ist das ''Gesetz zur Neuordnung der Organisationsstruktur im Bereich der Endlagerung'' in Kraft getreten. Es sieht vor, die staatlichen Aufgaben der Genehmigung und Aufsicht im Bereich der Kerntechnik, der Zwischenlagerung, der Standortauswahl und der Endlagerueberwachung mehrheitlich in einer neuen Behoerde zu buendeln, dem Bundesamt fuer kerntechnische Entsorgungssicherheit (BfE). Mit Inkrafttreten des Gesetzes wurden die entsprechenden Fachaufgaben des Bundesamtes fuer Strahlenschutz (BfS) auf das BfE uebertragen. Die Aufgabe zur Erstellung des jaehrlichen Statusberichtes zur Kernenergienutzung ist nunmehr Aufgabe des BfE. Fuer die operativen Aufgaben der Standortsuche, der Errichtung und des Betriebs der Endlager sowie der Schachtanlage Asse II und des Bergwerks Gorleben wird eine staatseigene Gesellschaft, die Bundesgesellschaft fuer Endlagerung (BGE), die Verantwortung uebernehmen. Der vorliegende Bericht mit dem Stand 31.12.2016 gibt einen Ueberblick ueber die Nutzung der Kernenergie in der Bundesrepublik Deutschland. Im Bericht aufgefuehrt sind die wesentlichen Daten aller Kernkraftwerke, Forschungsreaktoren und der Anlagen der Kernbrennstoffver- und -entsorgung. Zum Berichtszeitpunkt 31.12.2016 waren acht Kernkraftwerksbloecke in Betrieb. Die Stromerzeugung durch Kernenergie im Jahr 2016 betrug insgesamt ca. 84,6 TWh (2015: 91,8 TWh). Der Anteil der Kernenergie an der Gesamt-Brutto-Stromerzeugung betrug 13,0 % (2015: 14,2 %). Fuer die Kernkraftwerke enthaelt der Bericht in zusammengefasster Form die wesentlichen

78 FR 17079 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-03-20

... Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation... certain Rolls-Royce Deutschland Ltd & Co KG (RRD) models Tay 620-15 and Tay 650-15 turbofan engines. This... Tay 620-15 and Tay 650-15 turbofan engines with a low-pressure compressor (LPC) rotor disc assembly...

78 FR 71532 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-11-29

... Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. [[Page 71533... (AD) 2007-03- 02 for all Rolls-Royce Deutschland (RRD) Tay 620-15, Tay 650-15, and Tay 651-54 turbofan..., January 29, 2007) (``AD 2007-03-02'') for certain RRD Tay 611-8 and Tay 620-15 turbofan engines with LP...

78 FR 77382 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2013-12-23

... Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...-Royce Deutschland Ltd & Co KG (RRD) BR700-715A1-30, BR700-715B1- 30, and BR700-715C1-30 turbofan engines... turbofan engines installed on aircraft of U.S. registry. We also estimate that it would take about 24 hours...

Elevated Corticosterone Levels and Changes in Amphibian Behavior Are Associated with Batrachochytrium dendrobatidis (Bd Infection and Bd Lineage.

Directory of Open Access Journals (Sweden)

Caitlin R Gabor

Full Text Available Few studies have examined the role hormones play in mediating clinical changes associated with infection by the parasite Batrachochytrium dendrobatidis (Bd. Glucocorticoid (GC hormones such as corticosteroids (CORT regulate homeostasis and likely play a key role in response to infection in amphibians. We explore the relationship between CORT release rates and Bd infection in tadpoles of the common midwife toad, Alytes obstetricians, using a non-invasive water-borne hormone collection method across seven populations. We further examined whether tadpoles of A. muletensis infected with a hypervirulent lineage of Bd, BdGPL, had greater CORT release rates than those infected with a hypovirulent lineage, BdCAPE. Finally, we examined the relationship between righting reflex and CORT release rates in infected metamorphic toads of A. obstetricans. We found an interaction between elevation and Bd infection status confirming that altitude is associated with the overall severity of infection. In tandem, increasing elevation was associated with increasing CORT release rates. Tadpoles infected with the hypervirulent BdGPL had significantly higher CORT release rates than tadpoles infected with BdCAPE showing that more aggressive infections lead to increased CORT release rates. Infected metamorphs with higher CORT levels had an impaired righting reflex, our defined experimental endpoint. These results provide evidence that CORT is associated with an amphibian's vulnerability to Bd infection, and that CORT is also affected by the aggressiveness of infection by Bd. Together these results indicate that CORT is a viable biomarker of amphibian stress.

Acting jointly - with energy rationalism. The role of nuclear energy in Germany's self-commitment to reduce CO{sub 2}; Gemeinsam handeln - mit Energievernunft. Die Rolle der Kernenergie bei der Selbstverpflichtung Deutschlands zur CO{sub 2}-Minderung

Energy Technology Data Exchange (ETDEWEB)

Meller, E.; Hildebrand, M. [Vereinigung Deutscher Elektrizitaetswerke (VDEW) e.V., Frankfurt am Main (Germany)

1999-11-29

More than all the other partner states in the European Union the Federal Republic of Germany with an ambitious programme for the protection of the climate accepted the responsibility to comply with the obligations of the Kyoto Protocol to sustainably reduce the greenhouse gases. The German electricity suppliers as important players within the framework of the 'Selfcommitment of German Business on Climate Protection' never left any doubt that they would contribute their shares. At the same time great significance must be attached to the utilisation of nuclear energy. The goals of the policy for climate protection, however, would become waste paper under a withdrawal from nuclear energy as it is currently pursued by the Federal Government. (orig.) [German] Mehr als alle anderen Partnerstaaten in der Europaeischen Union hat die Bundesrepublik Deutschland mit ihrem anspruchsvollen Programm zum Schutz des Klimas Verantwortung uebernommen, den Verpflichtungen aus dem Kyoto-Protokoll nachzukommen, die Treibhausgase nachhaltig zu vermindern. Die deutschen Stromversorger als wichtiger Akteur im Rahmen der 'Selbstverpflichtung der deutschen Wirtschaft zur Klimavorsorge' haben keinen Zweifel daran gelassen, ihren Teil dazu beizutragen. Der Nutzung der Kernenergie kommt hierbei entscheidende Bedeutung zu. Mit einem Ausstieg aus der Kernenergie, wie ihn die Bundesregierung derzeit verfolgt, wuerden aber die Ziele der Klimaschutzpolitik Makulatur. (orig.)

Utilization of plant-derived recombinant human β-defensins (hBD-1 and hBD-2) for averting salmonellosis.

Science.gov (United States)

Patro, Sunita; Maiti, Soumitra; Panda, Santosh Kumar; Dey, Nrisingha

2015-04-01

We describe the use of plant-made β-defensins as effective antimicrobial substances for controlling salmonellosis, a deadly infection caused by Salmonella typhimurium (referred to further as S. typhi). Human β-defensin-1 (hBD-1) and -2 (hBD-2) were expressed under the control of strong constitutive promoters in tobacco plants, and bio-active β-defensins were successfully extracted. In the in vitro studies, enriched recombinant plant-derived human β-defensin-1 (phBD-1) and -2 (phBD-2) obtained from both T1 and T2 transgenic plants showed significant antimicrobial activity against Escherichia coli and S. typhi when used individually and in various combinations. The 2:1 peptide combination of phBD-1:phBD-2 with peptides isolated from T1-and T2-generation plants reduced the growth of S. typhi by 96 and 85 %, respectively. In vivo studies employing the mouse model (Balb/c) of Salmonella infection clearly demonstrated that the administration of plant-derived defensins individually and in different combinations enhanced the mean survival time of Salmonella-infected animals. When treatment consisted of the 2:1 phBD-1:phBD-2 combination, approximately 50 % of the infected mice were still alive at 206 h post-inoculation; the lowest number of viable S. typhi was observed in the liver and spleen of infected animals. We conclude that plant-made recombinant β-defensins (phBD-1 and phBD-2) are promising antimicrobial substances and have the potential to become additional tools against salmonellosis, particularly when used in combination.

Astrometric studies of the regions BD + 17 degree 4946, BD -5 degree 3071, and Ross 730-1

International Nuclear Information System (INIS)

Russell, J.; Gatewood, G.

1975-01-01

Positions, proper motions, and absolute parallaxes were found for 46 stars in the regions of BD +17 degree4946, BD -5 degree3071, and Ross 730-1. BD +17 degree4946 showed some evidence of irregular variations in position and magnitude. The residuals for Ross 730-1 were used in a preliminary study to test for an appropriate weighting system; a weak weighting system was indicated. (auth)

78 FR 11089 - Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick...

Science.gov (United States)

2013-02-15

...; Special Conditions No. 25-477-SC] Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500... special conditions. SUMMARY: These special conditions are issued for the Bombardier Aerospace Model BD-500...: Background On December 10, 2009, Bombardier Aerospace applied for a type certificate for their new Model BD...

Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

Directory of Open Access Journals (Sweden)

Wanyi Li

2014-03-01

Full Text Available Influenza (flu pandemics have exhibited a great threat to human health throughout history. With the emergence of drug-resistant strains of influenza A virus (IAV, it is necessary to look for new agents for treatment and transmission prevention of the flu. Defensins are small (2–6 kDa cationic peptides known for their broad-spectrum antimicrobial activity. Beta-defensins (β-defensins are mainly produced by barrier epithelial cells and play an important role in attacking microbe invasion by epithelium. In this study, we focused on the anti-influenza A virus activity of mouse β-defensin 1 (mBD1 and β defensin-3 (mBD3 by synthesizing their fusion peptide with standard recombinant methods. The eukaryotic expression vectors pcDNA3.1(+/mBD1-mBD3 were constructed successfully by overlap-PCR and transfected into Madin-Darby canine kidney (MDCK cells. The MDCK cells transfected by pcDNA3.1(+/mBD1-mBD3 were obtained by G418 screening, and the mBD1-mBD3 stable expression pattern was confirmed in MDCK cells by RT-PCR and immunofluorescence assay. The acquired stable transfected MDCK cells were infected with IAV (A/PR/8/34, H1N1, 0.1 MOI subsequently and the virus titers in cell culture supernatants were analyzed by TCID50 72 h later. The TCID50 titer of the experimental group was clearly lower than that of the control group (p < 0.001. Furthermore, BALB/C mice were injected with liposome-encapsulated pcDNA3.1(+/mBD1-mBD3 through muscle and then challenged with the A/PR/8/34 virus. Results showed the survival rate of 100% and lung index inhibitory rate of 32.6% in pcDNA3.1(+/mBD1-mBD3group; the TCID50 titer of lung homogenates was clearly lower than that of the control group (p < 0.001. This study demonstrates that mBD1-mBD3 expressed by the recombinant plasmid pcDNA3.1(+/mBD1-mBD3 could inhibit influenza A virus replication both in vitro and in vivo. These observations suggested that the recombinant mBD1-mBD3 might be developed into an agent for

Monitoring of the cogeneration agreement from 19th December 2003 for the partition combined heat and power. Reporting period 2010 (Fourth and last report); Monitoring der Kraft-Waerme-Kopplungs-Vereinbarung vom 19. Dezember 2003 fuer den Teilbereich Kraft-Waerme-Kopplung. Berichtszeitraum 2010 (Vierter und letzter Bericht)

Energy Technology Data Exchange (ETDEWEB)

Gores, Sabine; Harthan, Ralph O.

2012-06-04

Beside the obligation to implement the agreed measures, also the attendance of the 'Agreement between the Government of the Federal Republic of Germany and the German economy on the climate precaution, on the reduction of the CO{sub 2} emissions and on the promotion of the cogeneration in supplement to the climate agreement from 9th November, 2000' by a continuous was initiated. The Rheinisch-Westfaelisches Institut fuer Wirtschaftsforschung (Essen, Bundesrepublik Deutschland) was commissioned with the monitoring of the cogeneration agreement. The monitoring report under consideration is based on the monitoring reports and the relevant official statistics as well as data for the power generation from renewable energy sources.

Determination of the agricultural and process-related boundary conditions for the use of rapeseed oil and its refinery products as motor fuel. Final report; Ermittlung der landwirtschaftlichen, prozesstechnischen und verfahrenstechnischen Rahmenbedingungen fuer die Verwendung von Rapsoel und seiner Umwandlungsprodukte als Kraftstoff. Schlussbericht

Energy Technology Data Exchange (ETDEWEB)

Schliephake, D; Hacker, C M

1994-11-01

The use of rapeseed oil as a motor fuel is viewed from various angles: Production aspects; environmental aspects; marketing aspects in agriculture; business management aspects in the Federal Republic of Germany; production and refining of rapeseed oil; use of rapeseed oil methyl ester as diesel fuel and in mineral oil processing plants; engine performance. (orig./SR) [Deutsch] In dem vorliegenden Bericht wird der Einsatz von Rapsoel als Kraftstoff aus verschiedenen Blickwinkeln betrachtet: Produktionsaspekte, Umweltaspekte, marktwirtschaftliche Aspekte in der Landwirtschaft; betriebswirtschaftliche Aspekte in der Bundesrepublik Deutschland; Herstellung und Raffination von Rapsoel; Einsatz von Rapsoelmethylester als Dieselkraftstoff und in Anlagen der Mineraloelverarbeitung; Motortechnische Untersuchungsergebnisse. (orig./SR)

78 FR 75511 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

Science.gov (United States)

2013-12-12

... Inc., Models BD-500-1A10 and BD- 500-1A11 Series Airplanes; Electronic Flight Control System: Control... Inc. Models BD-500-1A10 and BD-500-1A11 series airplanes. These airplanes will have a novel or unusual... comments, data, or views. The most helpful comments reference a specific portion of the special conditions...

77 FR 69568 - Special Conditions: Bombardier Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick...

Science.gov (United States)

2012-11-20

... Aerospace, Model BD-500-1A10 and BD-500-1A11 Airplanes; Sidestick Controllers AGENCY: Federal Aviation... conditions for the Bombardier Aerospace Model BD-500-1A10 and BD-500-1A11 airplanes. These airplanes will... on the comments we receive. Background On December 10, 2009, Bombardier Aerospace applied for a type...

77 FR 30230 - Airworthiness Directives; Eurocopter Deutschland Helicopters

Science.gov (United States)

2012-05-22

... September 30, 2011. (g) Subject Joint Aircraft Service Component (JASC) Code: 2436: DC Generator Control... Deutschland GmbH Model MBB-BK117 C-2 helicopters with certain Generator Control Units (GCU) installed. This..., West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590-0001. Hand...

77 FR 69556 - Airworthiness Directives; Eurocopter Deutschland Helicopters

Science.gov (United States)

2012-11-20

..., 2011. (h) Subject Joint Aircraft Service Component (JASC) Code: 2436: DC Generator Control Unit. Issued... Deutschland GmbH (ECD) Model MBB-BK117 C-2 helicopters with certain Generator Control Units (GCU) installed... Ground Floor, Room W12- 140, 1200 New Jersey Avenue SE., Washington, DC 20590. FOR FURTHER INFORMATION...

Analyse der Literatur zu Klimawirkungen in Deutschland: ein Gesamtbild mit Lücken

Science.gov (United States)

Fleischhauer, Mark; Greiving, Stefan; Lindner, Christian; Lückenkötter, Johannes; Schauser, Inke

Dieses Kapitel präsentiert Ergebnisse einer umfassenden Literaturauswertung zu relevanten Klimawirkungen für Deutschland, die im Rahmen des Projekts "Netzwerk Vulnerabilität" vorgenommen wurde. Es zeigt auf, dass ein aggregiertes Gesamtbild der Klimawirkungen für Deutschland als Grundlage für Folgenabschätzungen und Anpassungsplanungen noch nicht gezeichnet werden kann, da eine große Bandbreite an Ansätzen zur Bewertung von Vulnerabilitäten oder Klimawandelfolgen existiert und die gegenwärtig vorhandenen Klimawirkungs- und Vulnerabilitätsstudien von großer Heterogenität gekennzeichnet sind. Als erster Schritt wird deshalb eine Zusammenschau bereits vorhandener Ansätze geliefert.

Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

Directory of Open Access Journals (Sweden)

Girolamo Jose Barrera

2013-09-01

Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent caries

Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

Directory of Open Access Journals (Sweden)

Girolamo Jose Barrera

2013-09-01

Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p < 0.01.Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent

Gas supplies from EC member states to customers in the Federal Republic of Germany; Gaslieferungen aus EG-Mitgliedstaaten an Abnehmer in der Bundesrepublik

Energy Technology Data Exchange (ETDEWEB)

Lukes, R. [Forschungsstelle Recht und Technik, Muenchen (Germany)

2000-12-01

After implementation of the EU Internal Gas Market Directive in Germany, marketers from EU member states are increasingly interested in entering the German natural gas market. In addition to the legal and competition aspects arising analogous to the internal market in electrity, as e.g. third party access to pipelines, management of physical transactions and use-of-pipeline pricing, natural gas trading of suppliers from EU member states in the German market has to be reviewed also from the angle of section 3 of the EnWG (German act for reform of the energy industry law), in which provisions are set forth governing and defining the case of energy supply to third parties, marketers being obliged to apply for a licence. The legal requirements and the various aspects to be considered are explained in detail. (Orig./CB) [German] Nach Ablauf der Umsetzungsfrist der Gas-Binnenmarktrichtlinie interessieren sich nunmehr auch GVU aus anderen Mitgliedstaaten fuer Gaslieferungen an Abnehmer in der Bundesrepublik. Allerdings tritt neben den beim Strom schon haeufig eroerterten Problemen von Netzzugang, Leitungskapazitaet, Nutzungsentgelt usw. die Frage auf, ob Gasversorgungsunternehmen (GVU) aus anderen Mitgliedstaaten bei Gaslieferungen an Abnehmer in der Bundesrepublik eine Energieversorgung anderer aufnehmen und deshalb der behoerdlichen Genehmigung nach Paragraph 3 EnWG beduerfen. Die Rechtslage wird analysiert. (orig./CB)

Characterization of Phosphate Transporters BdPT4 and BdPT8 in Mycorrhizal and Non-Mychorrhizal Brachypodium distachyon

DEFF Research Database (Denmark)

Clausen, Signe Sandbech

PT proteins were expressed in cells where direct PTs are believed to perform their function, as well as in the vascular tissue. In NM plants, BdPT4 was localized to the plasma membrane whereas BdPT8 accumulated in the endoplasmic reticulum (ER) in the secretory pathway. A similar expression pattern...... was observed in non-arbusculated cells of AM plants. In arbusculated cells, BdPT8 was detected in the ER while BdPT4 was localized to the plasma membrane and the periarbuscular membrane (PAM) surrounding the arbuscular trunk and thick branches, which further supported a role of both BdPTs in direct Pi uptake......Phosphorus (P) is an essential plant nutrient in agricultural production but the P rock reserves used for production of fertilizers are currently being depleted. One approach to reduce the demand on P fertilizers is to optimize the phosphate (Pi) uptake and utilization efficiency of crop plants...

Zur historischen Aufarbeitung und medialen Vermittlung der Shoah in Italien und Deutschland

Directory of Open Access Journals (Sweden)

Peter Kuon

2016-03-01

Full Text Available Claudia Müller, Patrick Ostermann und Karl-Siegbert Rehberg, Hrsg., Die Shoah in Geschichte und Erinnerung: Perspektiven medialer Vermittlung in Italien und Deutschland (Bielefeld: transcript, 2015.

High Production of 2,3-Butanediol (2,3-BD by Raoultella ornithinolytica B6 via Optimizing Fermentation Conditions and Overexpressing 2,3-BD Synthesis Genes.

Directory of Open Access Journals (Sweden)

Taeyeon Kim

Full Text Available Biological production of 2,3-butandiol (2,3-BD has received great attention as an alternative to the petroleum-based 2,3-BD production. In this study, a high production of 2,3-BD in fed-batch fermentation was investigated with a newly isolated bacterium designated as Raoultella ornithinolytica B6. The isolate produced 2,3-BD as the main product using hexoses (glucose, galactose, and fructose, pentose (xylose and disaccharide (sucrose. The effects of temperature, pH-control schemes, and agitation speeds on 2,3-BD production were explored to optimize the fermentation conditions. Notably, cell growth and 2,3-BD production by R. ornithinolytica B6 were higher at 25°C than at 30°C. When three pH control schemes (no pH control, pH control at 7, and pH control at 5.5 after the pH was decreased to 5.5 during fermentation were tested, the best 2,3-BD titer and productivity along with reduced by-product formation were achieved with pH control at 5.5. Among different agitation speeds (300, 400, and 500 rpm, the optimum agitation speed was 400 rpm with 2,3-BD titer of 68.27 g/L, but acetic acid was accumulated up to 23.32 g/L. Further enhancement of the 2,3-BD titer (112.19 g/L, yield (0.38 g/g, and productivity (1.35 g/L/h as well as a significant reduction of acetic acid accumulation (9.71 g/L was achieved by the overexpression of homologous budABC genes, the 2,3-BD-synthesis genes involved in the conversion of pyruvate to 2,3-BD. This is the first report presenting a high 2,3-BD production by R.ornithinolytica which has attracted little attention with respect to 2,3-BD production, extending the microbial spectrum of 2,3-BD producers.

BD+43° 3654 - a blue straggler?

Science.gov (United States)

Gvaramadze, V. V.; Bomans, D. J.

2008-07-01

The astrometric data on the runaway star BD+43° 3654 are consistent with the origin of this O4If star in the center of the Cyg OB2 association, while BD+43° 3654 is younger than the association. To reconcile this discrepancy, we suggest that BD+43° 3654 is a blue straggler formed via a close encounter between two tight massive binaries in the core of Cyg OB2. A possible implication of this suggestion is that the very massive (and therefore apparently very young) stars in Cyg OB2 could be blue stragglers as well. We also suggest that the binary-binary encounter producing BD+43° 3654 might be responsible for ejection of two high-velocity stars (the stripped helium cores of massive stars) - the progenitors of the pulsars B2020+28 and B2021+51.

Widespread occurrence of bd in French Guiana, South America.

Directory of Open Access Journals (Sweden)

Elodie A Courtois

Full Text Available The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1 determine its geographical distribution, (2 test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera to define sentinel species for future work, (3 track changes in prevalence through time and (4 determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012. At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4% as compared to Bufonidae (2.6 % and Hylidae (1.5%. In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

77 FR 71085 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2012-11-29

... Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines AGENCY: Federal Aviation... turbofan engines. This AD requires initial and repetitive general inspections and ultrasonic inspections...

Sales controlling comes into view. MIS (management information system) Deutschland GmbH fits energy suppliers; Vertriebscontrolling in Sicht. MIS Deutschland GmbH macht Energieversorger fit

Energy Technology Data Exchange (ETDEWEB)

Anon.

2002-03-01

MIS has integrated Microsoft-Excel efficiently, so appliers must not change other systems, can utilize advantages and know how and further functionalities like optimization of planning processes, automation of data processing, generation of a data base with structured information of energy data are available for customers.(GL) [German] Die MIS Deutschland GmbH wurde 1988 gegruendet. Die Gruender waren Studenten der Universitaet Darmstadt. Einer von ihnen ist noch heute Vorstandsvorsitzender der MIS AG. Schon damals hatte man die Vision, Manager oder die Entscheidungstraeger in Unternehmen mit Informationen zu versorgen und in die Lage zu versetzen, diese auch nach ihren Beduerfnissen auswerten, analysieren und reporten zu koennen. Dadurch entstand 1988 in Zusammenarbeit mit Microsoft die erste Microsoft-Excel-Konferenz in Deutschland. MIS hat Microsoft-Excel leistungsfaehig integriert, sodass der Anwender nicht auf ein anderes System umlernen muss, sondern die Vorteile und das Know-how Weiterverwenden kann und zusaetzlich weitere Funktionalitaeten zur Verfuegung gestellt bekommt. (orig.)

Die Zukunft des Sozialstaates Deutschland: Elemente einer Reformstrategie

OpenAIRE

Lampert, Heinz

1998-01-01

Die Notwendigkeit einer Reform des Sozialstaates Deutschland ist nach Auffassung des Autors evident, weil eine zu hohe Staats- und Sozialabgabenquote zu Steuervermeidung, Verringerung der Leistungsbereitschaft, Schwarzarbeit, Steuerhinterziehung, Korruption und Betrug führen und die Wettbewerbsfähigkeit der Wirtschaft gefährden. Der Sozialstaat, den der Verfasser als eine der großen Errungenschaften der Neuzeit interpretiert, kann nach seiner Überzeugung aber so reformiert werden, daß soziale...

77 FR 42958 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

Science.gov (United States)

2012-07-23

... airworthiness directive (AD) for Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 (all versions) and BO-105LS... tail rotor pitch link and subsequent loss of control of the helicopter. DATES: This AD becomes... improperly swaged spherical bearing on the pitch link, which could result in loss of tail rotor control and...

Anonimi, “Ges al meu grat non sui joglar” (BdT 461.126, “Per zo no·m voil desconortar” (BdT 461.193, “Va, cobla: al Juge de Galur” (BdT 461.246, “Seigner Juge, ben aug dir a la gen” (BdT 461.217, “Ges per li diz non er bons prez sabuz” (BdT 461.133

Directory of Open Access Journals (Sweden)

Giuseppe Noto

2012-09-01

Full Text Available My paper provides a new critical edition, with critical apparatus, comment and translation of a set of anonymous ‘coblas’, copied as a sequence in the anthology present at ff. 55-66 in chansonnier P: BdT 461.126; BdT 461.193; BdT 461.246; BdT 461.217; BdT 461.133 (all of which are unica. I will examine in particular the attributions suggested so far for one or more of these ‘coblas’ (a name that has frequently been put forward is that of Paolo Lanfranchi da Pistoia, author of the sonnet in ‘cobla’ form copied in P immediately preceding the poems discussed here and address the hypothesis put forward by several scholars (and upheld with convincing evidence by Stefano Asperti that the sequence under consideration points to the strong presence of a Tuscan tradition in chansonnier P, clearly contributing, among other things, to outline a “fundamental coherence” (Asperti between some aspects of Dante’s literary culture and this particular songbook.

Fundamentals of the natural gas industry. May 1997; Grundzuege der Erdgaswirtschaft. Mai 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [Deutsch] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

Fundamentals of the natural gas industry. November 1997; Grundzuege der Erdgaswirtschaft. November 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [Deutsch] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

Verein Deutscher Kohlenimporteure. Annual report 2000; Verein Deutscher Kohlenimporteure. Jahresbericht 2000

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-04-25

Energy economy developments of the world, the EU and West Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. (HS) [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt. (HS)

Verein Deutscher Kohlenimporteure. Annual report 2001; Verein Deutscher Kohlenimporteure. Jahresbericht 2001

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

Energy economy developments of the world, the EU and West Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt.

The natural gas industry - a survey; Erdgaswirtschaft - Eine Branche im Ueberblick

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-09-01

The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [German] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

Expression of beta-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: lack of upregulation in vivo upon Salmonella typhimurium infection.

Science.gov (United States)

Veldhuizen, Edwin J A; van Dijk, Albert; Tersteeg, Monique H G; Kalkhove, Stefanie I C; van der Meulen, Jan; Niewold, Theo A; Haagsman, Henk P

2007-01-01

Defensins are antimicrobial peptides that play an important role in the innate immune response in the intestine. Up to date, only one beta-defensin (pBD-1), has been described in pig, which was found to be expressed at low levels in the intestine. We set-up a quantitative PCR method to detect the gene expression of pBD-1 and a newly discovered porcine beta-defensin, pBD-2. Expression of pBD-1 mRNA increased from the proximal to the distal part of the intestine whereas pBD-2 expression decreased. The main gene expression sites for pBD-2 were kidney and liver, whereas pBD-1 was mainly expressed in tongue. The porcine small intestinal segment perfusion (SISP) technique was used to investigate effects of Salmonella typhimurium DT104 on intestinal morphology and pBD-1 and pBD-2 mRNA levels in vivo. The early responses were studied 2, 4 and 8 h post-infection in four separate jejunal and ileal segments. Immunohistochemistry showed invasion of the mucosa by Salmonella and changes in intestinal morphology. However, no concomitant changes in expression of either pBD-1 or pBD-2 were observed. We conclude that at least two defensins are differentially expressed in the intestine of pigs, and that expression of both defensins is not altered by S. typhimurium under these conditions.

78 FR 16196 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

Science.gov (United States)

2013-03-14

... directive (AD) for all Eurocopter Deutschland GmbH (ECD) EC 135 P1, P2, P2+, T1, T2, and T2+ helicopters..., except Federal holidays. The AD docket contains this proposed AD, the economic evaluation, any comments.... We prepared an economic evaluation of the estimated costs to comply with this proposed AD and placed...

Trajectory and physical properties of near-Earth asteroid 2009 BD

NARCIS (Netherlands)

Farnocchia, D.; Mommert, M.; Hora, J. L.; Chesley, S. R.; Vokrouhlický, D.; Trilling, D. E.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.; Knežević, Zoran; Lemaitre, Anne

2014-01-01

We analyze the trajectory of near-Earth asteroid 2009~BD, which is a candidate target of the NASA Asteroid Redirect Mission. The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational perturbations, such as

Hydro power in the German system of energy supply; Wasserkraft im Energiesystem Deutschland

Energy Technology Data Exchange (ETDEWEB)

Kaltschmitt, M. [Stuttgart Univ. (Germany). Abt. Neue Energietechnologie und Technikanalyse

1997-12-31

The technical potentials of electric power generation from hydro power in Germany, the current harnessing of hydro power, its costs, and certain characteristic quantities reflecting its effects on the environment are described. These diverse characteristic quantities are compared with those of other renewable and fossil energy sources used to generate electricity. On this basis, opportunities for extending the use of hydro power in Germany and its limits are discussed. (orig.) [Deutsch] Das Ziel der folgenden Ausfuehrungen ist, die technischen Potentiale und deren derzeitige Nutzung, die Kosten und bestimmte die Umwelteffekte beschreibende Kenngroessen einer Stromerzeugung aus Wasserkraft in Deutschland darzustellen. Diese unterschiedlichen Kenngroessen werden anschliessend mit denen anderer regenerativer Energien und fossiler Energietraeger zur Stromerzeugung verglichen. Ausgehend davon werden die Moeglichkeiten und Grenzen einer weitergehenden Wasserkraftnutzung im Energiesystem Deutschland diskutiert. (orig.)

MC-PELMO 3.0 - a computer model to estimate groundwater contamination caused by leaching of wood preservatives from storage sites of treated wood in Germany; Grundwassergefaehrdung durch Holzschutzmittel. MCPELMO 3.0 - ein mathematische Simulationsprogramm zur Abschaetzung der Grundwassergefaehrdung unter Holzlagerflaechen in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Klein, M. [Fraunhofer-Inst. fuer Molekularbiologie und Angewandte Oekologie, Schmallenberg-Grafschaft (Germany); Herrmann, M. [Umweltbundesamt, Berlin (Germany)

2004-07-01

verarbeitet dabei 22 ausgewaehlte Versickerungsszenarien, die ihrerseits aus der Verknuepfung von Leitboeden aus 12 Bodenregionen und Wetterdaten von 9 Klimastationen abgeleitet wurden. Diese Szenarien werden gewichtet mit den Standortdaten von Holzimpraegnierbetrieben in Deutschland. Als Ergebnis der Simulationsrechnungen werden statistische Wahrscheinlichkeiten fuer die Konzentrationen im Sickerwasser unter Holzlagerplaetzen in den vom Anwender ausgewaehlten Regionen angegeben. Ergebnisse und Diskussion. Die Ergebnisprotokolle der Simulationsrechnungen beinhalten sowohl mittlere Sickerwasserkonzentrationen als auch frei waehlbare Perzentile (50-99), sowie die jeweils maximale Standortkonzentration. Die Ergebnisse koennen in Relation zur Gesamtflaeche der Bundesrepublik, den jeweiligen forstlich genutzten Flaechenanteilen, oder zur Dichte von Holzschutzmittel anwendenden Betrieben dargestellt werden. Neben der Konzentration der Ausgangssubstanz koennen auch fuer mehrere Abbauprodukte Konzentrationen in der Grundwasserneubildung berechnet werden. Schlussfolgerungen. Das beschriebene Modell ist insbesondere zum Vergleich der Grundwassergefaehrdung durch verschiedene Holzschutzmittel geeignet. Die vergleichende Bewertung stellt ein neues Element der EU-Politik zur Chemikaliensicherheit dar, das zum ersten Mal in der Biozidrichtlinie 98/8/EG festgeschrieben wurde. Die Ergebnisse der Modellrechnungen identifizieren aber auch besonders gefaehrdete Regionen in Deutschland, fuer die geeignete Risikominderungsmassnahmen ergriffen werden muessen um das dortige Grundwasser zu schuetzen. (orig.)

Brauchen die Universitäten in Deutschland ein neues Paradigma der Nachwuchsausbildung?

NARCIS (Netherlands)

Enders, Jürgen

2005-01-01

Der Beitrag gibt einen neuen Überblick zum Stand der Forschungen über die Doktorandenausbildung in Deutschland und die weiteren beruflichen Werdegänge von Promovierten. Vor diesem Hintergrund werden Stärken und Schwächen der Nachwuchsförderung an den Hochschulen diskutiert. Die Analyse unterstreicht

RVX-297- a novel BD2 selective inhibitor of BET bromodomains

Energy Technology Data Exchange (ETDEWEB)

Kharenko, Olesya A., E-mail: olesya@zenithepigenetics.com [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); Gesner, Emily M.; Patel, Reena G.; Norek, Karen [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); White, Andre; Fontano, Eric; Suto, Robert K. [Xtal BioStructures, Inc., 12 Michigan Dr., Natick, MA 01760 (United States); Young, Peter R.; McLure, Kevin G.; Hansen, Henrik C. [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada)

2016-08-12

Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET inhibitor RVX-297 that is structurally related to the clinical compound RVX-208, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. We report that RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. We demonstrate the differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography, and describe the structural differences driving the BD2 selective binding of RVX-297. The isothermal titration calorimetry (ITC) data illustrate the related differential thermodynamics of binding of RVX-297 to single as well as dual BET bromodomains. - Highlights: • A novel inhibitor of BET bromodomains, RVX-297 is described. • The differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography are described. • RVX-297 preferentially binds to the BD2 domains of the BET bromodomains. • The structural and thermodynamic properties of the BD2 selective binding of RVX-297 are characterized.

Verein der Kohlenimporteure. Annual report 2002; Verein der Kohlenimporteure. Jahresbericht 2002

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Energy economy developments of the world, the European Union and the Federal Republic of Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der Europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt.

Das "Dänische Modell" des Wettbewerbs im Nahverkehr als Vorbild für die Organisation des ÖPNV in Deutschland

OpenAIRE

Haubitz, Martin

2004-01-01

Das Thema des Wettbewerbs im ÖPNV wird in Deutschland derzeit sehr umstritten, oft aber auch einseitig diskutiert. Allerdings ist an vielen Fachbeiträgen zu erkennen, dass in Deutschland kaum bekannt ist, was Wettbewerb im ÖPNV bedeutet. Die Gegner des Wettbewerbes stellen diesen so dar, als sei er geeignet, den deutschen ÖPNV komplett zum Erliegen zu bringen. Befürworter gibt es wenige. Der Verfasser dieser Arbeit hat jedoch bei Studien im Ausland festgestellt, dass offensichtlich der ko...

Bd/s -> mu+ mu- in ATLAS

CERN Document Server

Guenther, Jaroslav; The ATLAS collaboration

2016-01-01

The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied to provide new results presented in this talk. An upper limit is set on the branching ratio BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

Nuclear hBD-1 accumulation in malignant salivary gland tumours

International Nuclear Information System (INIS)

Wenghoefer, M; Merkelbach-Bruse, S; Fischer, HP; Novak, N; Winter, J; Pantelis, A; Dommisch, H; Götz, W; Reich, R; Bergé, S; Martini, M; Allam, JP; Jepsen, S

2008-01-01

Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this study was conducted to characterise proteins involved in cell cycle control and host defence in different benign and malignant salivary gland tumours in comparison with healthy salivary gland tissue. 21 paraffin-embedded tissue samples of benign (n = 7), and malignant (n = 7) salivary gland tumours as well as healthy (n = 7) salivary glands were examined immunohistochemically for the expression of p53, bcl-2, and hBD-1, -2, -3. HBD-1 was distributed in the cytoplasm of healthy salivary glands and benign salivary gland tumours but seems to migrate into the nucleus of malignant salivary gland tumours. Pleomorphic adenomas showed cytoplasmic as well as weak nuclear hBD-1 staining. HBD-1, 2 and 3 are traceable in healthy salivary gland tissue as well as in benign and malignant salivary gland tumours. As hBD-1 is shifted from the cytoplasm to the nucleus in malignant salivary gland tumours, we hypothesize that it might play a role in the oncogenesis of these tumours. In pleomorphic adenomas hBD-1 might be connected to their biologic behaviour of recurrence and malignant transformation

Far ultraviolet spectrophotometry of BD +28 4211

Science.gov (United States)

Cook, Timothy A.; Cash, Webster; Green, James C.

1991-01-01

The results are reported of a November 1989 rocket flight which recorded a flux-calibrated spectrum of BD +28 4211 from 912 to 1150 A with 1A resolution. BD +28 4211, an SdO-type star, is commonly used as an ultraviolet calibration source in the IUE wavelength band. The present work extends the useful range of this standard shortward of Lyman-alpha. Since previous experiments show marked disparity, this study can be useful in determining a standard in the 912 to 1216 A band.

Automobilkultur in der Bundesrepublik Deutschland - 50er und 60er Jahre

Directory of Open Access Journals (Sweden)

Schmidt, Gert

2010-08-01

Full Text Available The article deals with the impact of automobile-culture between the 1950s and the 1970s in Germany. The progress of ‚Automobilism’ has patterned every-day-life and culture in the Federal Republic of Germany as intensively as the development of auto-industry in the country has influenced the economy. West-Germany became in this period highly dependent on the auto-economy, and became a modern ‚car-society’.

Fixed Combination Aerosol Foam Calcipotriene 0.005% (Cal) Plus Betamethasone Dipropionate 0.064% (BD) is More Efficacious than Cal or BD Aerosol Foam Alone for Psoriasis Vulgaris

Science.gov (United States)

Tyring, Stephen; Bukhalo, Michael; Alonso-Llamazares, Javier; Olesen, Martin; Lowson, David; Yamauchi, Paul

2016-01-01

Objective: To evaluate the efficacy of fixed combination aerosol foam calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD). Design: Patients were randomized (100:101:101) to receive Cal/BD foam, Cal foam, or BD foam once daily for four weeks. Setting: Twenty-eight United States centers. Participants: 302 patients (≥18 years) with Psoriasis vulgaris (plaque Psoriasis; ≥mild disease severity by physicians global assessment). Measurements: Treatment success of the body (“clear”/”almost clear” from baseline moderate/severe disease; “clear” from baseline mild disease). Involved scalp treatment success was an additional endpoint. Results: Most patients (76%) had moderate Psoriasis of the body (66% for scalp). At Week 4, 45 percent of Cal/BD foam patients achieved treatment success, significantly more than Cal foam (14.9%; OR 4.34 [95%CI 2.16,8.72] Pfoam (30.7%; 1.81 [1.00,3.26] P=0.047). Fifty-three percent of Cal/BD foam patients achieved treatment success of the scalp, significantly greater than Cal foam (35.6%; 1.91 [1.09,3.35] P=0.021), but not BD foam (47.5%; 1.24 [0.71,2.16] P=0.45). Mean modified Psoriasis area and severity index (population baseline 7.6) improved in all groups, with statistically significant differences in Week 4 Cal/BD foam score (2.37) versus Cal foam (4.39; mean difference -2.03 [-2.63][-1.43] Pfoam (3.37; -1.19 [-1.80][-0.59] Pfoam was significantly more effective than Cal foam and BD foam in providing treatment success at Week 4 and effective on involved scalp. Trial registration: NCT01536938. PMID:27313822

Measurement of the B$_{d}^{0}$ meson oscillation frequency

CERN Document Server

Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Fernández, D; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Korolko, I; Koutsenko, V F; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino

1996-01-01

Time-dependent \\Bd-\\Bbd\\ mixing is studied using 1.5 million hadronic Z decays collected by L3. Semileptonic B decays are selected by requiring at least one reconstructed lepton in both thrust hemispheres. Charge correlations between the tagged leptons are studied as a function of proper time. The proper time of the b-hadron decay is measured by reconstructing the production and decay vertices using a silicon microvertex detector. The measured \\Bd\\ meson oscillation frequency corresponds to a mass difference \\Dmd\\ between the two \\Bd\\ mass eigenstates of \\begin{displaymath} \\Dmd = \\left( 0.496 ^{+ 0.055}_{- 0.051}\\ \\mathrm{(stat)} \\pm{ 0.043}\\ \\mathrm{(syst)} \\right)\\ \\mathrm{ps}^{-1}. \\end{displaymath}

Photochemistry of U(BH4)4 and U(BD4)4

International Nuclear Information System (INIS)

Paine, R.T.; Schonberg, P.R.; Light, R.W.; Danen, W.C.; Freund, S.M.

1979-01-01

U(BH 4 ) 4 and U(BD 4 ) 4 are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH 4 ) 3 , B 2 H 6 , H 2 , U(BD 4 ) 3 , B 2 D 6 and D 2 . Further, U(BD 4 ) 4 undergoes a related decomposition reaction under the influence of CO 2 laser irradiation at 924.97 cm -1 . (author)

77 FR 16917 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

Science.gov (United States)

2012-03-23

... heat treated after application of silver plating. We are issuing this AD to prevent failure of the HP... treatment after application of silver plating. This condition, if not corrected, could result in a stage 2... directive (AD): 2012-06-17 Rolls-Royce Deutschland Ltd & Co KG (Formerly Rolls-Royce plc, Derby, England...

Gutachten zu Forschung, Innovation und technologischer Leistungsfähigkeit Deutschlands 2015

OpenAIRE

EFI - Expertenkommission Forschung und Innovation (Berlin)

2015-01-01

Das Jahresgutachten 2015 der Expertenkommission Forschung und Innovation ist wie in den Vorjahren in drei Teile gegliedert. In den A-Kapiteln werden aktuelle Themen der F&I-Politik diskutiert. Schwerpunktanalysen werden in den B-Kapiteln vorgestellt. Das Gutachten dokumentiert zudem im C-Teil anhand von acht besonders relevanten Indikatorengruppen die Entwicklung und den Status quo Deutschlands im internationalen Vergleich. In Kapitel A 1 skizziert die Expertenkommission den Handlungsbedarf f...

Vitamin B@d12@@ concentrations in Mandovi and Zuari estuaries

Digital Repository Service at National Institute of Oceanography (India)

De; Rajendran, A.

Bioassay method using @iCyclotella nana@@ (clone 13) was employed for the estimation of Vitamin B@d12@@ in Mandovi and Zuari estuaries. At the mouth of the Mandovi estuary, B@d12@@ concentration varied between 0.38 and 7.0 ng/l in surface water...

Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 1: results and summary overview; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 1: Ergebnisse und zusammenfassende Uebersicht

Energy Technology Data Exchange (ETDEWEB)

Leisewitz, A.; Kruse, H.; Schramm, E.

2001-04-01

/Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

A MULTI-WAVELENGTH 3D MODEL OF BD+30°3639

Energy Technology Data Exchange (ETDEWEB)

Freeman, M. J.; Kastner, Joel H. [Chester F. Carlson Center for Imaging Science, School of Physics and Astronomy, and Laboratory for Multiwavelength Astrophysics, Rochester Institute of Technology, 54 Lomb Memorial Drive, Rochester NY 14623 (United States)

2016-10-01

We present a 3D multi-wavelength reconstruction of BD+30°3639, one of the best-studied planetary nebulae in the solar neighborhood. BD+30°3639, which hosts a [WR]-type central star, has been imaged at wavelength regimes that span the electromagnetic spectrum, from radio to X-rays. We have used the astrophysical modeling software SHAPE to construct a 3D morpho-kinematic model of BD+30°3639. This reconstruction represents the most complete 3D model of a PN to date from the standpoint of the incorporation of multi-wavelength data. Based on previously published kinematic data in optical emission lines and in lines of CO (radio) and H{sub 2} (near-IR), we were able to reconstruct BD+30's basic velocity components assuming a set of homologous velocity expansion laws combined with collimated flows along the major axis of the nebula. We confirm that the CO “bullets” in the PN lie along an axis that is slightly misaligned with respect to the major axis of the optical nebula, and that these bullets are likely responsible for the disrupted structures of the ionized and H{sub 2}-emitting shells within BD+30. Given the relative geometries and thus dynamical ages of BD+30's main structural components, it is furthermore possible that the same jets that ejected the CO bullets are responsible for the generation of the X-ray-emitting hot bubble within the PN. Comparison of alternative viewing geometries for our 3D reconstruction of BD+30°3639 with imagery of NGC 40 and NGC 6720 suggests a common evolutionary path for these nebulae.

Industrie 4.0. Standort Deutschland im internationalen Kontext: Vortrag gehalten beim 70. Deutschen Betriebswirtschafter-Tag, Digitalisierung, Vernetzung und disruptive Geschäftsmodelle - Betriebswirtschaftliche Implikationen des wirtschaftlichen Wandels, 28./29. September 2016, Düsseldorf

OpenAIRE

Bauernhansl, Thomas

2016-01-01

Der Vortrag "Industrie 4.0: Standort Deutschland im internationalen Kontext" behandelt folgende Themenkomplexe: - Internationaler Vergleich - Der Wettlauf um die Wertschöpfunghat begonnen - Digitale Transformation - Wo steht Deutschland international?

Nuclear hBD-1 accumulation in malignant salivary gland tumours.

NARCIS (Netherlands)

Wenghoefer, M.H.; Pantelis, A.; Dommisch, H.; Gotz, W.; Reich, R.; Berge, S.J.; Martini, M.; Allam, J.P.; Jepsen, S.; Merkelbach-Bruse, S.; Fischer, H.P.; Novak, N.; Winter, J.

2008-01-01

BACKGROUND: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this

LA BD EN CLASSE DE FLE ? POURQUOI PAS !

Directory of Open Access Journals (Sweden)

Ana-Marina Tomescu

2009-11-01

Full Text Available Dans la présente étude nous allons essayer de démontrer que la BD représente certainement un phénomène de civilisation, qui donne la possibilité aux apprenants d’une langue étrangère de mieux comprendre un comportement culturel spécifique. Elle aide les apprenants à améliorer leur compétence socio-culturelle, parce qu’elle fait ressortir des éléments de civilisation pertinents, des clichés fréquemment rencontrés dans le monde francophone. La langue utilisée dans les BD est le français de tous les jours, l’accent est mis sur la conversation dans les plus diverses situations et à l’aide des registres de langue différents. Ce sont des motifs suffisants qui recommandent l’utilisation de la BD en classe de FLE, sans oublier de mentionner un atout essentiel : l’humour.

Response of Superheated Droplet Detector (SDD) and Bubble Detector (BD) to interrupted irradiations

Energy Technology Data Exchange (ETDEWEB)

Mondal, Prasanna Kumar, E-mail: prasanna_ind_82@yahoo.com; Sarkar, Rupa, E-mail: sarkar_rupa2003@yahoo.com; Chatterjee, Barun Kumar, E-mail: barun_k_chatterjee@yahoo.com

2017-06-11

Superheated droplet detectors (SDD) and bubble detectors (BD) are suspensions of micron-sized superheated liquid droplets in inert medium. The metastable droplets can vaporise upon interaction with ionising radiation generating visible bubbles. In this work, we investigated the response of SDD and BD to interrupted neutron irradiations. We observed that the droplet vaporisation rates for SDD and BD are different in nature. The unusual increase in droplet vaporisation rate observed when the SDD is exposed to neutrons after few minutes of radiation-off period is absent for BD. - Highlights: • Superheated droplet detectors (SDD) and bubble detectors (BD) are suspensions of superheated liquid droplets in inert medium. • The bubble nucleation in superheated droplets can be induced by ionising radiation. • The droplet vaporisation rate for SDD is non-monotonic when it is irradiated periodically to neutrons. • For BD the droplet vaporisation rate decrease monotonically when it is irradiated periodically to neutrons.

78 FR 59291 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co. KG Turbofan Engines

Science.gov (United States)

2013-09-26

... received by the closing date and may amend this proposed AD based on those comments. We will post all.... Based on these figures, we estimate the cost of the proposed AD on U.S. operators to be $598,520... Deutschland GmbH, formerly Rolls-Royce plc): Docket No. FAA-2013- 0342; Directorate Identifier 2013-NE-14-AD...

Guillem Fabre, “Pus dels majors” (BdT 216.2; Id., “Hon mais vey, pus truep sordeyor” (BdT 216.1

Directory of Open Access Journals (Sweden)

Linda Paterson

2013-03-01

Full Text Available The historical circumstances of Guillem Fabre’s two surviving sirventes has given rise to widely divergent views. This essay builds on Parducci’s contextualisation of BdT 216.2 during the War of the Sicilian Vespers and the so-called Aragonese crusade by the French against Pere III of Aragon in 1284-1285. It argues that Guillem is likely to be referring to events say entre nos because Narbonne was the focal point of the gathering French army and preaching of the crusade. All other textual details are compatible with this period and best explained by this context. But while Parducci places the sirventes in May 1285, it must in fact have preceded the death of Martin IV on 29 March, since his speedily-appointed successor Honorius IV could not be blamed for not having preached a crusade against the heathen before the conflict degenerated into further atrocities. Furthermore a slightly earlier timing better explains the allusion to “the best-known man in the world”, the obvious candidate at this time being Charles of Anjou. Guillem probably composed BdT 216.2 during the build-up to war in 1284, before the death of Charles in January 1285, during the period of war preparations and propaganda speeches. It is also argued here that, pace Parducci, BdT 216.1 did not necessarily precede BdT 216.2.

SOA-BD: Service Oriented Architecture for Biomedical Devices

Directory of Open Access Journals (Sweden)

João Marcos Teixeira Lacerda

2017-05-01

Full Text Available Introduction: The communication of information systems with biomedical devices has become complex not only due to the existence of several private communication protocols, but also to the immutable way that software is embedded into these devices. In this sense, this paper proposes a service-oriented architecture to access biomedical devices as a way to abstract the mechanisms of writing and reading data from these devices, thus contributing to enable the focus of the development team of biomedical software to be intended for its functional requirements, i.e. business rules relevant to the problem domain. Methods The SOA-BD architecture consists of five main components: A Web Service for transport and conversion of the device data, Communication Protocols to access the devices, Data Parsers to preprocess data, a Device Repository to store data and transmitted information and Error handling, for error handling of these information. For the development of SOA-BD, technologies such as the XML language and the Java programming language were used. Besides, Software Engineering concepts such as Design Patterns were also used. For the validation of this work, data has been collected from vital sign monitors in an Intensive Care Unit using HL7 standards. Results The tests obtained a difference of about only 1 second in terms of response time with the use of SOA-BD. Conclusion SOA-BD achieves important results such as the reduction on the access protocol complexity, the opportunity for treating patients over long distances, allowing easier development of monitoring applications and interoperability with biomedical devices from diverse manufacturers.

Abfallverbrennung in Deutschland - Entwicklungen und Kapazitäten (KIT Scientific Reports ; 7560)

OpenAIRE

Richers, Ulf

2010-01-01

Die Verbrennung von Abfällen bildet in Deutschland seit vielen Jahrzehnten einen wichtigen Beitrag zur Abfallentsorgung. In der Arbeit werden im ersten Teil ausgewählte Standorte von Abfallverbrennungsanlagen ausführlich beschrieben, um die Vielfalt der technischen Realisierungsmöglichkeiten und die Veränderungen im Lauf der Zeit zu dokumentieren. Der zweite Teil umfasst die Bestimmung der Verbrennungskapazität von deutschen Abfallverbrennungsanlagen, die überwiegend Siedlungsabfälle einsetze...

Snapchat in Deutschland: Wie verwenden Nutzer die App und was publizieren Medienmarken?

OpenAIRE

Gerhards, Claudia

2017-01-01

Obgleich Snapchat im Mediennutzungsverhalten insbesondere von Teenagern eine zunehmend wichtige Rolle spielt, liegen für Deutschland bislang kaum Erkenntnisse dazu vor, wie Funktionen und Inhalte der App tatsächlich von Usern genutzt werden und welche Inhalte- und Gestaltungserwartungen diese an Snapchat-Auftritte von Marken knüpfen. Zudem fehlt es an Untersuchungen, die Aufschluss darüber geben, in welchem Umfang deutsche Medienmarken mit eigenen Snapchat-Accounts aktiv sind, welche Inhalte ...

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity.

Science.gov (United States)

Bailleul, Geoffrey; Kravtzoff, Amanda; Joulin-Giet, Alix; Lecaille, Fabien; Labas, Valérie; Meudal, Hervé; Loth, Karine; Teixeira-Gomes, Ana-Paula; Gilbert, Florence B; Coquet, Laurent; Jouenne, Thierry; Brömme, Dieter; Schouler, Catherine; Landon, Céline; Lalmanach, Gilles; Lalmanach, Anne-Christine

2016-01-01

Defensins are frontline peptides of mucosal immunity in the animal kingdom, including birds. Their resistance to proteolysis and their ensuing ability to maintain antimicrobial potential remains questionable and was therefore investigated. We have shown by bottom-up mass spectrometry analysis of protein extracts that both avian beta-defensins AvBD2 and AvBD7 were ubiquitously distributed along the chicken gut. Cathepsin B was found by immunoblotting in jejunum, ileum, caecum, and caecal tonsils, while cathepsins K, L, and S were merely identified in caecal tonsils. Hydrolysis product of AvBD2 and AvBD7 incubated with a panel of proteases was analysed by RP-HPLC, mass spectrometry and antimicrobial assays. AvBD2 and AvBD7 were resistant to serine proteases and to cathepsins D and H. Conversely cysteine cathepsins B, K, L, and S degraded AvBD2 and abolished its antibacterial activity. Only cathepsin K cleaved AvBD7 and released Ile4-AvBD7, a N-terminal truncated natural peptidoform of AvBD7 that displayed antibacterial activity. Besides the 3-stranded antiparallel beta-sheet typical of beta-defensins, structural analysis of AvBD7 by two-dimensional NMR spectroscopy highlighted the restricted accessibility of the C-terminus embedded by the N-terminal region and gave a formal evidence of a salt bridge (Asp9-Arg12) that could account for proteolysis resistance. The differential susceptibility of avian defensins to proteolysis opens intriguing questions about a distinctive role in the mucosal immunity against pathogen invasion.

Emission control at stationary sources in the Federal Republic of Germany. Vol 1. Sulphur oxide and nitrogen oxide emission control; Massnahmen zur Emissionsminderung bei stationaeren Quellen in der Bundesrepublik Deutschland. Bd. 1. Minderung der SO{sub 2}- und NO{sub x}-Emissionen

Energy Technology Data Exchange (ETDEWEB)

Rentz, O; Schleef, H J; Dorn, R; Sasse, H; Karl, U

1997-05-01

Primaer- und Sekundaermassnahmen in den emissionsrelevanten Industriesektoren fuer SO{sub 2}- und NO{sub x} in Deutschland. Der Bericht gibt einen Ueberblick ueber die Entwicklung der SO{sub 2}- und NO{sub x}-Emissionen in ausgewaehlten europaeischen Laendern waehrend der letzten 20 Jahre und in Europa. Daran schliessen sich aktuelle nationale und europaeische Grenzwerte und Richtlinien zu der SO{sub 2}- und NO{sub x} Emissionen aus stationaeren Quellen an. Der Anwendungsstand von Massnahmen zur Minderung der SO{sub 2}- und NO{sub x}-Emissionen wird fuer jeden relevanten Industriesektor untersucht und primaere Minderungsoptionen beschrieben. Spezielle Prozesseinheiten mit direktem Kontakt von Flamme und Prozessgut werden in den einzelnen Prozessen diskutiert, waehrend externe Verbrennungsprozesse zur ausschliesslichen Bereitstellung von Prozesswaerme und elektrischer Energie sektoruebergreifend in einem separaten Kapitel behandelt werden. Der Bericht schliesst mit einem Ueberblick ueber die zur Verfuegung stehenden sekundaeren Minderungsmassnahmen. Fuer die einzelnen Sektoren werden Beispiele fuer Investitionen und Kosten fuer installierte Minderungstechnologien gegeben, die als einzelfallabhaengig anzusehen sind. Zusaetzlich stellten die Anbieter von Emissionsminderungstechnologien Verfahrensbeschreibungen ihrer Produkte einschliesslich Referenzen zur Verfuegung, die im Bericht enthalten sind. (orig.)

Saudi production capacity climbing to 10 million b/d

International Nuclear Information System (INIS)

Anon.

1994-01-01

Saudi Arabia this year is completing its expansion of production capacity and developing recent discoveries to enhance export flexibility. The 3 million b/d capacity expansion to 10 million b/d, announced in 1989, is on target for completion by year end 1994. Most of the effort involves restoration of mothballed production equipment and installation of several gas-oil separation plants (GOSPs) in existing fields. But Saudi Arabian Oil Co. (Saudi Aramco) also this year will start up production of extra-light oil from a new field in the central part of the kingdom. Start-up of Hawtah area production demonstrates success of an oil search Aramco began after receiving exclusive exploration rights to nearly all of Saudi Arabia's prospective area in 1986. From new fields and traditional producing areas, therefore, Saudi Arabia has the potential to expand production capacity beyond 10 million b/d. The paper describes the development of the extra capacity

Fourth report by the Federal German Government to the Bundestag on measures for the protection of the ozone layer; 4. Bericht der Bundesregierung an den Deutschen Bundestag ueber Massnahmen zum Schutz der Ozonschicht

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-07-01

This report, which relates the situation as of July 1997, again confirms the internationally leading role of the Federal German Republic in the phase-out of CFCs. No country has realised a more comprehensive concept for the phase-out of substances that deplete the ozone layer. Combining statutory and voluntary measures has proved a path-breaking approach. One of the most important driving forces in the CFC phase-out were the restrictions of use imposed by the Ordinance on the Prohibition of CFCs and Halon. (orig./SR) [Deutsch] Dieser Bericht - mit Stand vom Juli 1997 - bestaetigt erneut die internationale Fuehrungsrolle der Bundesrepublik Deutschland beim FCKW-Ausstieg. In keinem anderen Staaat wurde ein umfassenderes Konzept zum Ausstieg aus den ozonabbauenden Stoffen realisiert. Als wegweisend hat sich dabei die Verknuepfung ordnungsrechtlicher und freiwilliger Massnahem erwiesen. Insbesondere von den Verwendungsbeschraenkungen der FCKW-Halon-Verbots-Verordnung gingen wichtige Impulse beim FCKW-Ausstieg aus. (orig./SR)

"BiC in Sustainability?" : die Transparenz von Best in Class-Nachhaltigkeitsfonds in Deutschland

OpenAIRE

Schäfer, Henry; Bauer, Fabian; Bracht, Felix

2015-01-01

Der vorliegende Beitrag analysiert in Deutschland vertriebene Publikumsinvestmentfonds, die den Anspruch als Nachhaltigkeitsfonds erheben und nach dem Best in Class-Ansatz (BiC-Ansatz) in Kombination mit einem Negative-Screening (verstanden als Ausschlusskriterien) konstruiert sind. Ziel ist es zu erheben, auf welche Weise die den Fonds vom Anbieter zugrunde gelegten BiC- und Screening-Methoden Anlegern transparent gemacht werden und worin zwischen den Fonds diesbezüglich Unterschiede bestehe...

Mining lakes in Germany; Tagebauseen in Deutschland. Gegenwaertiger Kenntnisstand ueber wasserwirtschaftliche Belange von Braunkohlentagebaurestloechern - ein Ueberblick

Energy Technology Data Exchange (ETDEWEB)

Nixdorf, B.; Hemm, M.; Schlundt, A.; Kapfer, M.; Krumbeck, H. [Brandenburgische Technische Univ., Cottbus (Germany). Lehrstuhl Gewaesserschutz]|[UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Magdeburg (Germany)

2001-06-01

More than 500 mining lakes of different age and maturity have formed in the lignite mining areas in Germany during the last hundred years. Compared to natural lakes mining lakes have a complex and diverse morphometry. They will be among the largest and deepest lakes in Germany (Hambacher See, Goitsche, Garzweiler II, Geiseltal) and have good chance of avoiding eutrophication. About 100 mining lakes will be greater than 50 ha. 230 lakes are documented in this report concerning morphometry, flooding and mixis regime, hydrochemistry, limnology, colonization, use and development of water quality. They are among the largest (Hambacher See, Goitsche, Garzweiler II, Geiseltal) and most acidic lakes in Germany. The extremely high acidity is from both iron and hydrogen ions due to pyrit oxidation. It influences trophic situation and food webs in mining lakes and reduces a diverse use of these lakes. (orig.) [German] Die Seelandschaft Deutschlands wird durch den Braunkohlenbergbau um ueber 500 Seen reicher. Technologiebedingt herrscht dabei eine grosse morphologische Vielfalt innerhalb der Tagebauseen vor, welche die groessten und tiefsten Seen Deutschlands hervorbringen wird (Hambacher See, Goitsche, Garzweiler II, Geiseltal), aber auch zahlreiche kleine, meist flachere Gewaesser miteinschliesst. Etwa 100 Taugebauseen sind groesser als 50 ha. Kleinere Tagebauseen wie z.B. die der Ville in Nordrhein-Westfalen wurden ebenfalls ausfuehrlich dokumentiert. In dieser Dokumentation wurden ueber 490 Seen erfasst, 230 davon wurden in der Dokumentation nach folgenden Kriterien beschrieben: Entstehung, Flutungsregime, Morphometrie und Mixis, Chemismus und Gewaesserentwicklung, Besiedlung und Nutzung. Dem Problem der Versauerung durch die Verwitterung sulfidischer Mineralien (Pyrit, Markasit) wurde besondere Aufmerksamkeit gewidmet, weil sich biologische Komponenten und Gewaesserzustaende (Trophie, Nahrungsketten) abweichend zu den normalen Hartwasserseen Deutschlands verhalten und

One-dimensional nodal neutronics routines for the TRAC-BD1 thermal-hydraulics program

International Nuclear Information System (INIS)

Nigg, D.W.

1983-09-01

Nuclear reactor core transient neutronic behavior is currently modeled in the TRAC-BD1 code using a point-reactor kinetics formulation. This report describes a set of subroutines based on the Analytic Nodal Method that were written to provide TRAC-BD1 with a one-dimensional space-dependent neutronics capability. Use of the routines is illustrated with several test problems. The results of these problems show that the Analytic Nodal neutronics routines have desirable accuracy and computing time characteristics and should be a useful addition to TRAC-BD1

AutoBD: Automated Bi-Level Description for Scalable Fine-Grained Visual Categorization.

Science.gov (United States)

Yao, Hantao; Zhang, Shiliang; Yan, Chenggang; Zhang, Yongdong; Li, Jintao; Tian, Qi

Compared with traditional image classification, fine-grained visual categorization is a more challenging task, because it targets to classify objects belonging to the same species, e.g. , classify hundreds of birds or cars. In the past several years, researchers have made many achievements on this topic. However, most of them are heavily dependent on the artificial annotations, e.g., bounding boxes, part annotations, and so on . The requirement of artificial annotations largely hinders the scalability and application. Motivated to release such dependence, this paper proposes a robust and discriminative visual description named Automated Bi-level Description (AutoBD). "Bi-level" denotes two complementary part-level and object-level visual descriptions, respectively. AutoBD is "automated," because it only requires the image-level labels of training images and does not need any annotations for testing images. Compared with the part annotations labeled by the human, the image-level labels can be easily acquired, which thus makes AutoBD suitable for large-scale visual categorization. Specifically, the part-level description is extracted by identifying the local region saliently representing the visual distinctiveness. The object-level description is extracted from object bounding boxes generated with a co-localization algorithm. Although only using the image-level labels, AutoBD outperforms the recent studies on two public benchmark, i.e. , classification accuracy achieves 81.6% on CUB-200-2011 and 88.9% on Car-196, respectively. On the large-scale Birdsnap data set, AutoBD achieves the accuracy of 68%, which is currently the best performance to the best of our knowledge.Compared with traditional image classification, fine-grained visual categorization is a more challenging task, because it targets to classify objects belonging to the same species, e.g. , classify hundreds of birds or cars. In the past several years, researchers have made many achievements on this topic

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study

Directory of Open Access Journals (Sweden)

Moreno-Manzanaro Miriam

2011-04-01

Full Text Available Abstract Background Studies in bipolar disorder (BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd (NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales, adherence to treatment (DAI-10 scale and Medication Possession Ratio, quality of life (EQ-5D scale, healthcare resources, and caregiver burden (BAS scale

Literatur zu Gast im Globe

CERN Multimedia

2006-01-01

Der deutsche Schriftsteller Thomas LEHR liest am 23. März 2006 aus seinem Roman '42', einem philosophischen Abenteuerroman über die Suche nach der Zeit, erzählt in einer funkelnden und souveränen Sprache. Eine Welt von vernichtender Schönheit und bizarren Schrecken wartet auf eine Besuchergruppe, die in der Nähe von Genf die unterirdischen Anlagen des Forschungszentrums für Teilchenphysik CERN besichtigt. Als sie um 12:47:42 wieder ans Tageslicht tritt, scheint ganz Europa in einen Dornröschenschlaf gefallen. Allein die 70 Besucher können sich noch bewegen. Monate und Jahre verharrt die Welt wie in einer riesigen dreidimensionalen Fotografie, bis ein wiederum schockierendes Ereignis die 'Chronifizierten' aus ihren physikalischen Spekulationen und seltsamen Lebensformen reisst. Zu dieser literarischen Veranstaltung im 'Globe of Science and Innovation' laden gemeinsam das Generalkonsulat der Bundesrepublik Deutschland in Genf und CERN ein. Vor Beginn der Lesung wird eine Führung in deutscher Sprac...

Solar-assisted central heating in Hamburg-Bramfeld; Solarunterstuetzte Nahwaermeversorgung Hamburg-Bramfeld

Energy Technology Data Exchange (ETDEWEB)

Ebel, M. [HGC Hamburg Gas Consult, Hamburg (Germany)

1998-12-31

About 38% of the energy consumed in Germany is used for space heating. Hot water demand of old buildings accounts for approximately 10% while buildings constructed according to modern insulation standards account for 15 - 20 %. Space heating has a considerable conservation potential, which plays an important role in terms of reducing carbon dioxide pollution. More and more new technologies for conventional thermal insulation as well as for the active use of solar energy are being developed and will soon be commercially available. (orig.) [Deutsch] In der Bundesrepublik Deutschland werden ca. 38% des Energieverbrauches fuer die Waermeversorgung von Gebaeuden eingesetzt. Auf den Warmwasserbedarf entfallen davon ca. 10% bei Altbauten und 15-20% bei Wohngebaeuden nach den heute gueltigen Waermeschutzbestimmungen. Damit liegt im Bereich der Waemreversorgung von Gebaeuden ein erhebliches Einsparpotential, welches innerhalb der Diskussion ueber die CO{sub 2}-Problematik eine immer groessere Bedeutung erlangt. Neben einer Verbesserung der konventionellen Waermedaemmung der Gebaeude werden zunehmend Techniken der aktiven Solarenergienutzung zur Einsatzreife entwickelt. (orig.)

Pflege – eine Sache der ganzen Familie

Directory of Open Access Journals (Sweden)

Nicole Maly-Lukas

2005-07-01

Full Text Available Derzeit sind in der Bundesrepublik Deutschland ca. 2 Millionen Menschen pflegebedürftig. Etwa 1,4 Millionen werden im häuslichen Bereich – in der Regel von Familienmitgliedern gepflegt – z. T. mit professioneller Unterstützung. Die Familie ist also weiterhin „der größte Pflegedienst der Nation“. Und es sind hauptsächlich die Frauen, die sich für die Pflege von Familienmitgliedern verantwortlich fühlen. Gröning et al. möchten sich in ihrem Buch In guten wie in schlechten Tagen aber nicht auf die Belastungen der pflegenden Frauen beschränken. Sie stellen die Generationen- und Geschlechterbeziehungen, die einen großen Einfluss auf die familiäre Pflegebeziehung haben, in den Vordergrund. In dem Buch Pflegegeschichten kommen rund 40 pflegende Angehörige selbst zu Wort, indem sie ‚ihre‘ persönliche „Pflegegeschichte“ erzählen.

DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects.

Science.gov (United States)

Polesello, Vania; Zupin, Luisa; Di Lenarda, Roberto; Biasotto, Matteo; Pozzato, Gabriele; Ottaviani, Giulia; Gobbo, Margherita; Crovella, Sergio; Segat, Ludovica

2017-01-01

The aetiology of Oral Lichen Planus (OLP), a chronic inflammatory disease of oral mucosa, is not yet well understood. Since innate immunity may be hypothesized as involved in the susceptibility to OLP, we studied human beta defensin 1 (hBD-1) an antimicrobial peptide constitutively expressed in the saliva, looking at functional genetic variants possibly able to diminish hBD-1 production an consequently conferring major susceptibility to OLP. We analysed three DEFB1 polymorphisms at 5' UTR, -52G>A (rs1799946), -44C>G (rs1800972), -20G>A (rs11362) and two DEFB1 polymorphisms at 3'UTR, c*5G>A (rs1047031), c*87A>G (rs1800971), with the aim of correlating these genetic variants and hBD-1 salivary level in a group of OLP patients and in healthy subjects. We also evaluated hBD-1 salivary concentrations, using ELISA, in OLP and healthy controls. We compared hBD-1 concentrations in OLP and healthy subjects: hBD-1 concentration was significantly higher in OLP patients respect to control. When considering the correlation between DEFB1 polymorphisms genotypes and hBD-1 expression levels, significant results were obtained for SNPs -52G>A (p=0.03 both in OLP patients and healthy individuals) and -44C>G (p=0.02 in OLP patients). hBD-1 production was different between OLP and healthy subjects (not age-matched with OLP). DEFB1 gene polymorphisms, -52G>A and -44C>G, correlated with hBD-1 salivary concentrations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cloning and analysis of the full-length cDNA of reindeer β-defensin caBD-1%驯鹿β-防御素reBD-1全长cDNA的克隆及序列分析

Institute of Scientific and Technical Information of China (English)

杨银凤; 郝永峰; 赵艳芳; 余兴帮; 都格尔斯仁

2008-01-01

为了获得驯鹿β-防御素reBD-1全长cDNA序列,根据已获得的reBD-1 cDNA的已知序列设计1条序列特异性引物作为上游引物,反转录引物中的部分序列即3′接舍器引物作为下游引物,克隆reBD-1 cDNA的3′末端序列.另外,采用反向嵌套PCR RACE法,根据reBD-1 cDNA的已知序列,设计1条5′末端磷酸化的特异性反转录引物和2对特异性反向嵌套PCR引物,首先进行反转录(RT),然后将mRNA反转录成的cDNA进行环化,最后进行反向嵌套巢式PCR,克隆reBD-1 cDNA的5′末端序列.结果成功的克隆出了reBD-1 cDNA的3′和5′末端序列,从而得到372 bp的reBD-1 cDNA全序列,其中包含44 bp 5′非翻译区(UTR)、192 bp的开放读码框(ORF)、终止密码子TAA、118 bp的3′UTR和poly(A)15.reBD-1 cDNA全序列的获得为进一步研究其基因结构、基因表达和基因功能奠定了基础.

High Milk-Clotting Activity Expressed by the Newly Isolated Paenibacillus spp. Strain BD3526

Directory of Open Access Journals (Sweden)

Feng Hang

2016-01-01

Full Text Available Paenibacillus spp. BD3526, a bacterium exhibiting a protein hydrolysis circle surrounded with an obvious precipitation zone on skim milk agar, was isolated from raw yak (Bos grunniens milk collected in Tibet, China. Phylogenetic analysis based on 16S rRNA and whole genome sequence comparison indicated the isolate belong to the genus Paenibacillus. The strain BD3526 demonstrated strong ability to produce protease with milk clotting activity (MCA in wheat bran broth. The protease with MCA was predominantly accumulated during the late-exponential phase of growth. The proteolytic activity (PA of the BD3526 protease was 1.33-fold higher than that of the commercial R. miehei coagulant. A maximum MCA (6470 ± 281 SU mL−1 of the strain BD3526 was reached under optimal cultivation conditions. The protease with MCA was precipitated from the cultivated supernatant of wheat bran broth with ammonium sulfate and purified by anion-exchange chromatography. The molecular weight of the protease with MCA was determined as 35 kDa by sodium dodecyl sulfate-polyacrylamide gels electrophoresis (SDS-PAGE and gelatin zymography. The cleavage site of the BD3526 protease with MCA in κ-casein was located at the Met106–Ala107 bond, as determined by mass spectrometry analysis.

Robustness Property of Robust-BD Wald-Type Test for Varying-Dimensional General Linear Models

Directory of Open Access Journals (Sweden)

Xiao Guo

2018-03-01

Full Text Available An important issue for robust inference is to examine the stability of the asymptotic level and power of the test statistic in the presence of contaminated data. Most existing results are derived in finite-dimensional settings with some particular choices of loss functions. This paper re-examines this issue by allowing for a diverging number of parameters combined with a broader array of robust error measures, called “robust- BD ”, for the class of “general linear models”. Under regularity conditions, we derive the influence function of the robust- BD parameter estimator and demonstrate that the robust- BD Wald-type test enjoys the robustness of validity and efficiency asymptotically. Specifically, the asymptotic level of the test is stable under a small amount of contamination of the null hypothesis, whereas the asymptotic power is large enough under a contaminated distribution in a neighborhood of the contiguous alternatives, thus lending supports to the utility of the proposed robust- BD Wald-type test.

Evaluation of the BD Max Cdiff assay for the detection of toxigenic Clostridium difficile in human stool specimens.

Science.gov (United States)

Putsathit, Papanin; Morgan, Justin; Bradford, Damien; Engelhardt, Nelly; Riley, Thomas V

2015-02-01

The Becton Dickinson (BD) PCR-based GeneOhm Cdiff assay has demonstrated a high sensitivity and specificity for detecting Clostridium difficile. Recently, the BD Max platform, using the same principles as BD GeneOhm, has become available in Australia. This study aimed to investigate the sensitivity and specificity of BD Max Cdiff assay for the detection of toxigenic C. difficile in an Australian setting. Between December 2013 and January 2014, 406 stool specimens from 349 patients were analysed with the BD Max Cdiff assay. Direct and enrichment toxigenic culture were performed on bioMérieux ChromID C. difficile agar as a reference method. isolates from specimens with discrepant results were further analysed with an in-house PCR to detect the presence of toxin genes. The overall prevalence of toxigenic C. difficile was 7.2%. Concordance between the BD Max assay and enrichment culture was 98.5%. The sensitivity, specificity, positive predictive value and negative predictive value for the BD Max Cdiff assay were 95.5%, 99.0%, 87.5% and 99.7%, respectively, when compared to direct culture, and 91.7%, 99.0%, 88.0% and 99.4%, respectively, when compared to enrichment culture. The new BD Max Cdiff assay appeared to be an excellent platform for rapid and accurate detection of toxigenic C. difficile.

Photochemistry of U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/

Energy Technology Data Exchange (ETDEWEB)

Paine, R T; Schonberg, P R; Light, R W [New Mexico Univ., Albuquerque (USA). Dept. of Chemistry; Danen, W C; Freund, S M

1979-01-01

U(BH/sub 4/)/sub 4/ and U(BD/sub 4/)/sub 4/ are observed to undergo complex degradation reactions promoted by broadband UV radiation. The primary products of these reactions appear to be U(BH/sub 4/)/sub 3/, B/sub 2/H/sub 6/, H/sub 2/, U(BD/sub 4/)/sub 3/, B/sub 2/D/sub 6/ and D/sub 2/. Further, U(BD/sub 4/)/sub 4/ undergoes a related decomposition reaction under the influence of CO/sub 2/ laser irradiation at 924.97 cm/sup -1/.

Validity and reliability of the Brief version of Quality of Life in Bipolar Disorder" (Bref QoL.BD) among Chinese bipolar patients.

Science.gov (United States)

Xiao, Lin; Gao, Yulin; Zhang, Lili; Chen, Peiyun; Sun, Xiaojia; Tang, Siyuan

2016-03-15

Previous literatures on quality of life (QoL) in bipolar disorder (BD) strongly suggested that a disease-specific QoL measure for patients with BD should be developed to evaluate QoL more specifically and reliably. To our knowledge, "Quality of Life in Bipolar Disorder" (QoL.BD) is the first and only questionnaire produced to specifically measure QoL in people with BD. In China, there is no disease-targeted measure available to specifically measure QoL in Chinese patients with BD. The aim of the study is to revise and validate the brief version of the QoL.BD (Bref QoL.BD ) into Chinese version. All the items of the Bref QoL.BD was translated into Chinese language, using the Brislin translation mode. The questionnaire was administered to a total sample of 231 subjects, including 101 BD patients and 130 healthy controls, to test the psychometric properties of Bref QoL.BD (e.g. internal consistency, retest reliability, content validity, item analysis, confirmatory factor analysis, criterion validity, convergent validity, discriminative validity and feasibility). The Chinese version of the Bref QoL.BD had very high internal consistency (Cronbach's alpha=0.815) and retest reliability (intraclass correlation coefficient (ICC )=0.808). Confirmatory factor analysis (CFA) validated the original one-factor structure. The direction and magnitude of correlations with 36-item Short-Form Health Survey (SF-36; rs= 0.313, Psize from only one tertiary care center. And BD patients enrolled were euthymic, excluding the acute BD patients. The Chinese version of the Bref QoL.BD is a feasible, reliable and valid tool for the assessment of QoL for Chinese BD patients. Copyright © 2015 Elsevier B.V. All rights reserved.

Relative accuracy of the BD Logic and FreeStyle blood glucose meters.

Science.gov (United States)

2007-04-01

The BD Logic((R)) (Becton, Dickinson and Co., Franklin Lakes, NJ) and FreeStyle((R)) (Abbott Diabetes Care, Alameda, CA) meters are used to transmit data directly to insulin pumps for calculation of insulin doses and to calibrate continuous glucose sensors as well as to monitor blood glucose levels. The accuracy of the two meters was evaluated in two inpatient studies conducted by the Diabetes Research in Children Network (DirecNet). In both studies, meter glucose measurements made with either venous or capillary blood were compared with reference glucose measurements made by the DirecNet Central Laboratory at the University of Minnesota using a hexokinase enzymatic method. The BD Logic tended to read lower than the laboratory reference regardless of whether venous (median difference = -9 mg/dL) or capillary blood (median difference = -7 mg/dL) was used. This resulted in lower accuracy of the BD Logic compared with the FreeStyle meter based on the median relative absolute difference (RAD) for both venous blood (median RAD, 9% vs. 5%, P blood (median RAD, 11% vs. 6%, P = 0.008). The greatest discrepancy in the performance of the two meters was at higher reference glucose values. Accuracy was not significantly different when the reference was < or = 70 mg/dL. The BD Logic meter is less accurate than the FreeStyle meter.

Effect of chloride substitution on the order–disorder transition in NaBH4 and Na11BD4

International Nuclear Information System (INIS)

Olsen, Jørn Eirik; Karen, Pavel; Sørby, Magnus H.; Hauback, Bjørn C.

2014-01-01

Graphical abstract: Interactions that order the BD 4 - tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na( 11 BD 4 ) 1−x Cl x solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH 4 ) 1−x Cl x and Na( 11 BD 4 ) 1−x Cl x is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na( 11 BD 4 ) 1−x Cl x for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na 11 BD 4 at room temperature and 8 K and Na( 11 BD 4 ) 1−x Cl x (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na 11 BD 4 (NaBH 4 ) and its solid solutions with NaCl, Na( 11 BD 4 ) 1−x Cl x , is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na 11 BD 4 , ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na( 11 BD 4 ) 1−x Cl x follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na 11 BD 4 ) at 8 K

The analysis of B-d ->(eta, eta ')l(+)l(-) decays in the standard model

NARCIS (Netherlands)

Erkol, G; Turan, G

We study the differential branching ratio, the branching ratio and the CP-violating asymmetry for the exclusive B-d --> (eta,eta')l(+)l(-) decays in the standard model. We deduce the B-d --> (eta,eta') form factors from the form factors of B --> pi available in the literature, by using the SU(3)(F)

Effect of hBD2 genetically modified dermal multipotent stem cells on repair of infected irradiated wounds

International Nuclear Information System (INIS)

Zong Zhaowen; Li Nan; Xiao Taoyuan

2010-01-01

Deficiencies in repair cells and infection are two of the main factors that can hinder the process of wound healing. In the present study, we investigated the ability of human beta-defensin-2 (hBD2) genetically modified dermal multipotent stem cells (dMSCs) to accelerate the healing irradiated wounds complicated by infections. An hBD2 adenovirus expression vector (Adv-hBD2) was firstly constructed and used to infect dMSCs. The antibacterial activity of the supernatant was determined by Kirby-Bauer method and macrodilution broth assay. Time to complete wound healing, residual percentage of wound area, and the number of bacteria under the scar were measured to assess the effects of Adv-hBD2-infected dMSC transplantation on the healing of irradiated wounds complicated by Pseudomonas aeruginosa infection. Results showed that the supernatant from Adv-hBD2-infected dMSCs had obvious antibacterial effects. Transplantation of Adv-hBD2-infected dMSCs killed bacteria in the wound. The complete wound healing time was 19.8±0.45 days, which was significantly shorter than in the control groups (P<0.05). From 14 days after transplantation, the residual wound area was smaller in the experimental group than in the control groups (P<0.05). In conculsion, we found that transplantation of hBD2 genetically modified dMSCs accelerated the healing of wounds complicated by P. aeruginosa infection in whole body irradiated rats. (author)

Mixing and CP violation in the Bd and Bs systems at ATLAS

CERN Document Server

AUTHOR|(INSPIRE)INSPIRE-00229256; The ATLAS collaboration

2016-01-01

This note includes a measurement of the $B^0_s$ decay parameters in the $ B_s \\rightarrow J/\\psi$ channel and a measurement of the $B_d$ meson using the statistics collected by the ATLAS experiment in Run I of the LHC. The first result presents the measurement of the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the width difference between the mass eigenstates $\\Delta \\Gamma_s$. The second result presents the measurement of the width difference $\\Delta \\Gamma_d$, which is extracted from the measurement of the lifetime dependence of $B_d \\to J/\\psi K_S$ and $B_d \\to J/\\psi K^{*0}$ decays. The obtained results are $\\phi_s = −0.098 \\pm 0.084 (\\textrm{stat.}) \\pm 0.040 (\\textrm{syst.})$ rad. and $\\Delta \\Gamma_d / \\Gamma_d = (-0.1 \\pm 1.1 (\\textrm{stat.}) \\pm 0.9 (\\textrm{syst.}))\\times 10^{-2}$.

The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance.

Directory of Open Access Journals (Sweden)

Julia Leclerc

Full Text Available Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance.

75 FR 61343 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG (RRD) Models Tay 620-15, Tay 650-15...

Science.gov (United States)

2010-10-05

... adopting the AD as proposed. Costs of Compliance Based on the service information, we estimate that this AD... cost about $100,000 per product. Based on these figures, we estimate the cost of the AD on U.S... Rolls-Royce Deutschland Ltd & Co KG (Formerly Rolls-Royce plc): Amendment 39-16457. Docket No. FAA-2010...

Biodegradable plastics. A contribution to promoting composting in Germany; Bioabbaubare Kunststoffe. Ein Beitrag zur Foerderung der Kompostierung in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Hamprecht, Jens [BASF SE, Ludwigshafen (Germany)

2012-11-01

Up to 80% of all Germans use newspapers for collecting biomass waste, even if it is unhygienic and the paper will soak. This is just one of the many examples of the Germans' readiness to separate waste fractions and save resources. Separation of biomass waste and composting is another field where Germany is ahead of other countries, but the potential is still not fully utilized by far. More hygienic collecting of biomass waste would be possible if biodegradable plastic containers were used. (orig.) [German] Bis zu 80% der Buerger in Deutschland verwenden bisher Zeitung zum Sammeln von Bioabfaellen, selbst wenn es unhygienisch ist und die Zeitung leicht durchweicht. Und das ist nur einer von vielen Beweisen fuer die hohe Bereitschaft der Deutschen zur Abfalltrennung und damit zur Ressourcenschonung. Kein Wunder also, dass in Deutschland auch die Bioabfalltrennung und Kompostierung im Vergleich zu anderen Laendern sehr weit entwickelt ist. Trotzdem ist das Potential noch bei weitem nicht ausgeschoepft. Mit Hilfe von bioabbaubaren Kunststoffen kann den Buergern eine hygienischere Sammlung von Bioabfall ermoeglicht werden. (orig.)

Feministische Rechtswissenschaft in Deutschland Feminist legal scholarship in Germany

Directory of Open Access Journals (Sweden)

Susanne Baer

2000-07-01

Full Text Available Die Frage nach gleichen Rechten und nach dem, was genau geschlechtsbezogene Benachteiligung im und durch eventuell auch neutral klingendes Recht ausmacht, ist auf der Grundlage des 1994 eingefügten verfassungsrechtlichen Gleichstellungsgebotes in Art. 3 Abs. 2 S. 2 Grundgesetzes neu zu beantworten. Die Bücher von Ines Kalisch und Jutta Schumann leisten dazu Beiträge, die auch den Fortschritt feministischer Rechtswissenschaft in Deutschland dokumentieren.The doctrine of human rights and equality and the analysis of factors which constitute gender inequality and discrimination in and by law, even those laws seemingly neutral at first glance, has to be rethought after the German constitution was amended in 1994 to include a right to equality in social reality. These books by Ines Kalisch and Jutta Schumann add to our understanding of these legal questions, and also present the rise in feminist legal scholarship in Germany.

Ätiologie und Prävalenz permanenter kindlicher Hörstörungen in Deutschland

OpenAIRE

Spormann-Lagodzinski, ME; Nubel, K; König, O; Gross, M; Gross, M

2003-01-01

Permanente Hörstörungen bei Kindern haben in den letzten Jahren bezüglich Ätiologie und Prävalenz einen deutlichen Wandel erlebt. In den westlichen Industrienationen ist sie auf 1 bis 3 pro 1.000 Neugeborene gesunken. Nach Ergebnissen des Deutschen Zentralregisters für kindliche Hörstörungen (DZH) liegt die Prävalenz in Deutschland bei ca. 1,2:1.000. Von 6.200 ausgewerteten Datensätzen des DZH haben 36% aller permanenten Hörstörungen eine (vermutlich oder gesichert) genetische Ursache, 18% si...

Prokaryotic Expression of Reindeer β-defensin-1 (reBD-1) Gene and Bioactivity Identification of the Recombinant Protein%驯鹿β-防御素-1(reBD-1)基因的原核表达及蛋白活性的鉴定

Institute of Scientific and Technical Information of China (English)

苏丽娜; 杨银凤; 景岚; 曹贵方

2011-01-01

The aim of this experiment was to construct prokaryotic expression vector of reindeer β-defensin-l(reBD-l), induce the expression of reBD-1 fusion protein in E. Coli, and evaluate the bioactivity of the expression products. The prepro-peptide of reBD-1 was amplified by RT-PCR. The mature peptide of encoding reBD-1 was amplified from recombinant cloning vector PMD19T/ reBD-1, and then cloned into pET-32a (+ ), in which reBD-1 fusion protein expression was induced by IPTG in E. Coli BL2KDE3). The expressed product was further cultured and purified for experiment of bacteriostasis in vitro. The results showed that the amplified products of prepro-peptide and mature peptide were 215 and 138 bp, respectively, and the homology of the sequences of the targeted gene and reBD-1 mRNA was up to 100%. The molecular weight of fusion proteins of prepro-peptide and mature peptide were 28 and 24 ku. The agar diffusion method has demonstrated that 0. 08 mg · mL-1 purified mature peptide protein has obvious antimicrobial activity against S. Aureus and E. Coli. From the results we can conclude that the prepro-peptide and mature peptides have high expression level in E. Coli, and the mature peptide has resistance to both Gram negative and Gram positive bacteria.%旨在构建驯鹿β防御素-1(Reindeerβ-defensin-1,reBD-1)基因的原核表达载体pET-32a(+ )/reBD-1,诱导reBD-1融合蛋白在大肠杆菌中表达,并对其表达产物的生物学活性进行评价.利用RT-PCR技术扩增reBD-1前原肽.从重组克隆载体PMD19T/reBD-1中扩增reBD-1成熟肽编码基因,并克隆入pET-32a(+)中,在大肠杆菌BL21 (DE3)中用IPTG诱导表达reBD-1融合蛋白.表达的融合蛋白扩大培养,进一步纯化后进行体外抑菌试验.结果表明,reBD-1前原肽和成熟肽扩增产物大小分别为215和138 bp,目的基因的序列与驯鹿防御素-1 mRNA序列同源性为100％.前原肽和成熟肽融合蛋白分子量分别为28和24 ku.利用琼脂糖扩散法表明,0

Information to go: Kommunikation im Prozess der Migration am Beispiel syrischer und irakischer Flüchtlinge auf ihrem Weg nach Deutschland

Directory of Open Access Journals (Sweden)

Anke Fiedler

2016-07-01

Full Text Available Vor dem Hintergrund der Flüchtlingsdebatte in Deutschland 2015 wird in diesem Beitrag danach gefragt, welche (Massen-Kommunikationskanäle Flüchtlinge vor, während und nach der Flucht nutzen, um sich über migrationsrelevante Themen zu informieren und sich darüber mit anderen Migrationswilligen auszutauschen. Dabei wird nicht nur die Frage nach der subjektiven Bewertung der genutzten Quellen gestellt, sondern auch untersucht, ob die Flüchtlinge eine informierte Entscheidung in den verschiedenen Phasen der Migration treffen. Auf Basis des Uses-and-Gratifications-Ansatzes und der Handlungstheorie (symbolischer Interaktionismus wurden zwischen November 2015 und Februar 2016 vier Fokusgruppen und 36 Tiefeninterviews mit syrischen und irakischen Flüchtlingen durchgeführt. Die Ergebnisse verdeutlichen, dass sich die befragten Flüchtlinge vor und während der Flucht gut informiert fühlten, da persönliche Kontakte und soziale Medien die Informationsbedürfnisse weitgehend befriedigen konnten. Informationsdefizite zeigten sich vor allem nach der Ankunft in Deutschland.

EXTREMISMUS IM KLASSENZIMMER - THEORETISCHE CHANCEN UND MÖGLICHKEITEN DES POLITIKUNTERRICHTES.

Directory of Open Access Journals (Sweden)

Amelie Zuschke

2015-06-01

Full Text Available Durch Phänomene wie PEGIDA wird eine Unsicherheit in der Bevölkerung ausgedrückt, die auch vor den Schultüren nicht Halt macht. Ein Querschnitt der Gesellschaft sitzt im Klassenraum und auf diesen muss sich eingestellt werden. Ob Kinder zuhause oder in ihrer Freizeit mit Populismus konfrontiert werden, die Schule hat als immer größerer Teil im Leben von Schülern in Deutschland (im Zuge der nach und nach fortschreitenden Einführung eines Ganztages-Prinzips auch eine Verantwortung mit diesen Eindrücken und Einflüssen bedacht umzugehen. Deutschland sollte aus der eigenen Geschichte heraus zudem die aufmerksame und sensible Handhabung mit extremem Gedankengut im Allgemeinen und mit rechtsextremistischem Gedankengut im Besonderen haben. Die Tendenz zu den politischen Extremen in wirtschaftlich und sozial herausfordernden Zeiten ist ein mit jedem wirtschaftlichen Abschwung auftretendes Phänomen, aber stark nationalistisches Gedankengut ist mit der heutigen Idealvorstellung von einem offenen Europa nicht vereinbar. In der Bundesrepublik Deutschland fußt die politische Bildung, geschichtlich begründet, auf demokratievermittelnden Prinzipien. Diese eignen sich vielseitig für die Auseinandersetzung mit Extremismus und den hierzu unumstrittenen Grundlagen und Werte der pluralistischen Gesellschaft in einer Demokratie. Das Kontroversitätsgebot des Beutelsbacher Konsenses aus dem Jahr 1977 (vgl Breit/Massig, 1993 bietet einen Ansatz zur Behandlung von Extremismus in der politischen Bildung auf der Grundlage der gegenseitigen Akzeptanz. Hier wird das Kontroversitätsgebot aufgeschlüsselt und anschließend auf Extremismus in der Schule bezogen. Die Fragestellung, wie der Politikunterricht trotz des Kontroversitätsgebotes mit Extremismus umgehen sollte, ist auf den Umgang mit dem gegenwärtigen Rechtsextremismus ausgelegt, welcher einen großen Teil politisch motivierter Straftaten begründet, sich in radikalisierter Form am stärksten gegen

Energy for Germany 2000. Facts, views and positions in a global trend. Goals of the global and national policies in the 21st century: Competitive strength, assured supply, environmental compatibility; Energie fuer Deutschland 2000. Fakten, Perspektiven und Positionen im globalen Kontext. Schwerpunktthema 'Ziel globaler und nationaler Energiepolitik im 21. Jahrhundert: Wettbewerbsfaehig - versorgungssicher - umweltvertraeglich'

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

The publication is based on the publication 'Energy for Tomorrow's World - Acting Now.', which was published by the World Energy Council in 2000. It presents an analysis of the current situation and contains suggestions for actions that should be taken in the period up to 2020. While national energy policy will still be required, it can only be successful if global aspects are not neglected. This includes the consideration of the responsibility of the industrial nations for third world countries. The energy concept presented here intends to take account of the decisive global aspects. [German] Die Darstellung der globalen Aspekte stuetzt sich auf die Standortbestimmung 2000 des Weltenergierates 'Energy for Tomorrow's World - Acting Now.'. Diese Standortbestimmung unterzieht die Anfang der 90er Jahre erschienene globale Studie des Weltenergierates einer kritischen Ueberpruefung, stellt Abweichungen von den damals angenommenen Entwicklungsperspektiven fest und gibt vor allem konkrete Handlungsempfehlungen fuer die Zeit bis zum Jahr 2020, also fuer die Zeitspanne, die konkret ueberschaubar und gestaltbar ist. Die neue Standortbestimmung des Weltenergierates unterstreicht, dass nationale Energiepolitik zwar weiterhin notwendig ist, aber nur dann auf Dauer erfolgreich sein wird, wenn sie auf diese globalen Aspekte ausgerichtet ist. Dazu gehoert auch, dass westliche, entwickelte Laender sich bewusst sind, dass eine nationale Energiepolitik zu Lasten der Dritten Welt nicht nur keine Zukunft hat, sondern vor allem nicht zu verantworten ist. Dies gilt natuerlich ebenso fuer die Umweltpolitik. An diesen Massstaeben wird sich auch das konkrete Energiekonzept messen lassen muessen, das nun fuer die Bundesrepublik Deutschland auf der Basis des 'Energiedialogs 2000' erarbeitet werden soll. Mit der hier vorgelegten Publikation will das Deutsche Nationale Komitee des Weltenergierates dazu beitragen, dass in diesem Energiekonzept die

Disrupting the cinnamyl alcohol dehydrogenase 1 gene (BdCAD1) leads to altered lignification and improved saccharification in Brachypodium distachyon.

Science.gov (United States)

Bouvier d'Yvoire, Madeleine; Bouchabke-Coussa, Oumaya; Voorend, Wannes; Antelme, Sébastien; Cézard, Laurent; Legée, Frédéric; Lebris, Philippe; Legay, Sylvain; Whitehead, Caragh; McQueen-Mason, Simon J; Gomez, Leonardo D; Jouanin, Lise; Lapierre, Catherine; Sibout, Richard

2013-02-01

Brachypodium distachyon (Brachypodium) has been proposed as a model for grasses, but there is limited knowledge regarding its lignins and no data on lignin-related mutants. The cinnamyl alcohol dehydrogenase (CAD) genes involved in lignification are promising targets to improve the cellulose-to-ethanol conversion process. Down-regulation of CAD often induces a reddish coloration of lignified tissues. Based on this observation, we screened a chemically induced population of Brachypodium mutants (Bd21-3 background) for red culm coloration. We identified two mutants (Bd4179 and Bd7591), with mutations in the BdCAD1 gene. The mature stems of these mutants displayed reduced CAD activity and lower lignin content. Their lignins were enriched in 8-O-4- and 4-O-5-coupled sinapaldehyde units, as well as resistant inter-unit bonds and free phenolic groups. By contrast, there was no increase in coniferaldehyde end groups. Moreover, the amount of sinapic acid ester-linked to cell walls was measured for the first time in a lignin-related CAD grass mutant. Functional complementation of the Bd4179 mutant with the wild-type BdCAD1 allele restored the wild-type phenotype and lignification. Saccharification assays revealed that Bd4179 and Bd7591 lines were more susceptible to enzymatic hydrolysis than wild-type plants. Here, we have demonstrated that BdCAD1 is involved in lignification of Brachypodium. We have shown that a single nucleotide change in BdCAD1 reduces the lignin level and increases the degree of branching of lignins through incorporation of sinapaldehyde. These changes make saccharification of cells walls pre-treated with alkaline easier without compromising plant growth. © 2012 The Authors The Plant Journal © 2012 Blackwell Publishing Ltd.

Deutschland und Polen: Kooperation trotz Differenzen; die Beziehungen zu Warschau sollten realpolitisch gedacht und verfolgt werden

OpenAIRE

Lang, Kai-Olaf

2018-01-01

Das Verhältnis zwischen Deutschland und Polen befindet sich in einer schwierigen Phase. Diverse bilaterale Streitpunkte sind dafür verantwortlich, dass sich die Beziehungen verschlechtert haben - darunter der mögliche Bau der Gaspipeline Nord Stream 2 durch die Ostsee, polnische Reparationsforderungen an die Adresse Berlins sowie europapolitischer Disput etwa um Aufnahmequoten für Flüchtlinge. Zudem hat Brüssel ein Verfahren nach Artikel 7 des EU-Vertrags eingeleitet - als Reaktion auf die in...

Vergleich des Studiums der Tiermedizin in München (Deutschland) und in Liège (Belgien)

OpenAIRE

Schaller, Christine Birgit Silvia Verena

2014-01-01

Das Ziel der vorliegenden Arbeit war es, durch einen Vergleich des Studiums der Tiermedizin in München und in Liège die Gemeinsamkeiten und die Unterschiede zwischen diesen beiden Fakultäten zu analysieren. In Deutschland kann das Studium der Tiermedizin an fünf Hochschulen, unter anderem in München, absolviert werden. In der Französischen Gemeinschaft Belgiens gibt es vier Universitäten, die den Bachelor-Studiengang der Tiermedizin anbieten, jedoch ist Liège die einzige Universität, in we...

Baden-Wuerttemberg. Energy report `94; Baden-Wuerttemberg. Energie-Bericht `94

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-11-01

The energy report reviews the energy policy of the Land Baden-Wuerttemberg in the light of the national and international situation in the year under report. Tables and diagrams present data and information on the worldwide energy consumption, the energy consumption in the European Union and in the Federal Republic of Germany as well as on the energy supplies of the Land Baden-Wuerttemberg; Energy consumption; primary energy consumption; end-use energy consumption; rational use of energy; mineral oil; coal; electricity; natural gas; district heating; renewable energy sources; energy supply structures; the energy balance of Baden-Wuerttemberg for the past year; and more. (orig./HS) [Deutsch] Der Energiebericht gibt einen Ueberblick ueber die Energiepolitik Baden-Wuerttembergs im nationalen und internationalen Rahmen fuer das Berichtsjahr. Tabellen und Graphiken informieren ueber die wichtigsten Daten zum Energieverbrauch weltweit, in der Europaeischen Union und in der Bundesrepublik Deutschland sowie zur Energieversorgung des Landes Baden-Wuerttemberg: Energieverbrauch; Primaerenergieverbrauch; Endenergieverbrauch; rationelle Nutzung von Energie; Mineraloel; Kohle; Strom; Erdgas; Fernwaerme; erneuerbare Energien; Versorgungsstrukturen; energiebedingte Emissionen; Energiebilanz Baden-Wuerttemberg fuer das Vorjahr; und mehr. (orig./HS)

Survey of the energy market in Germany in 2000. Primary energy consumption - carbon dioxide emissions - mineral oil - lignite - coal - natural gas - electricity - energy prices - import bill; Deutscher Energiemarkt 2000. Primaerenergie - Treibhausgas-Emissionen - Mineraloel - Braunkohle - Steinkohle - Erdgas - Elektrizitaet - Energiepreise - Importrechnung

Energy Technology Data Exchange (ETDEWEB)

Schiffer, H.W. [RWE Rheinbraun AG, Koeln (Germany)

2001-03-01

Primary energy consumption in Germany in 2000 amounted to 483.6m tonnes of coal equivalent and thus decreased by 0.2%, as compared to 1999. The comprehensive survey consists of tabulated data and explanatory comments relating to the developments linked to the various energy sources, change of energy mix, generation technologies and systems, demand factors and consumer behavior, carbon dioxide emissions, renewable energies and cogeneration and the government policies, imports and prices. (orig./CB) [German] Der Primaerenergieverbrauch in der Bundesrepublik Deutschland belief sich im Jahr 2000 auf 483,6 Millionen Tonnen Steinkohleneinheiten (Mio. t SKE), d.h. er war 0,2% niedriger als im Vorjahr. Hinsichtlich der Entwicklung in 2000 im Vergleich zu 1999 wurden u.a. folgende Tendenzen festgestellt: 1. Wandel im Energiemix. 2. Rueckgang der CO2-Emissionen, ausser im Verkehrssektor. 3. Gestiegenes Mineraloelaufkommen, aber veraenderte Zusammensetzung. 4. Anstieg bei Gewinnung und Einsatz von Braunkohle, Verringerung bei Steinkohle. Die Daten werden erlaeutert, wobei auch auf geaenderte rechtliche Rahmenbedingungen und die neuere Energiepolitik hingewiesen wird. (orig./CB)

Baden-Wuerttemberg. Energy report 97; Baden-Wuerttemberg. Energie-Bericht 97

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The energy report reviews the energy policy of the Land Baden-Wuerttemberg in the light of the national and international situation in the year under report. Tables and diagrams present data and information on the worldwide energy consumption, the energy consumption in the European Union and in the Federal Republic of Germany as well as on the energy supplies of the Land Baden-Wuerttemberg: energy consumption; primary energy consumption; end-use energy consumption; rational use of energy; mineral oil; coal; electricity; natural gas; district heating; renewable energy sources; energy supply structures; the energy balance of Baden-Wuerttemberg for the past year; and more. (orig.) [Deutsch] Der Energiebericht gibt einen Ueberblick ueber die Energiepolitik Baden-Wuerttembergs im nationalen und internationalen Rahmen fuer das Berichtsjahr. Tabellen und Graphiken informieren ueber die wichtigsten Daten zum Energieverbrauch weltweit, in der Europaeischen Union und in der Bundesrepublik Deutschland sowie zur Energieversorgung des Landes Baden-Wuerttemberg: Energieverbrauch; Primaerenergieverbrauch; Endenergieverbrauch; rationelle Nutzung von Energie; Mineraloel; Kohle; Strom; Erdgas; Fernwaerme; Erneuerbare Energien; Versorgungsstrukturen; Energiebedingte Emissionen; Energiebilanz Baden-Wuerttemberg fuer das Vorjahr; und mehr. (orig.)

Schlechte Zeiten fur Bildung: Globalisierung, Deregulierung und Privatisierung im Landervergleich Turkei und Bundesrepublik Deutschland.

Science.gov (United States)

Ugeoz, Perihan

1998-01-01

States that the increasingly unrestricted growth of competition places national public institutions of education under escalating pressure. Notes that creeping privatization is passing more costs of education onto the citizen. Argues that this internationally subversive process is seldom critically addressed but is instead dominated by a high-brow…

Dextran synthesized by Leuconostoc mesenteroides BD1710 in tomato juice supplemented with sucrose.

Science.gov (United States)

Han, Jin; Hang, Feng; Guo, Benheng; Liu, Zhenmin; You, Chunpin; Wu, Zhengjun

2014-11-04

The characteristics of the growth of Leuconostoc mesenteroides BD1710 and the synthesis of dextran in tomato juice supplemented with 15% sucrose were assayed. L. mesenteroides BD1710 could synthesize approximately 32 g L(-1) dextran in the tomato-juice-sucrose medium when cultured at 28 °C for 48 h, which was on the same level as the dextran yield in a chemically defined medium. The viscosity of the cultured tomato-juice-sucrose medium with various dextran contents was also measured. The results of the monosaccharide composition, molecular-weight distribution, Fourier transform infrared spectra (FTIR) and nuclear magnetic resonance spectra (NMR) showed that the polysaccharide synthesized by L. mesenteroides BD1710 in the tomato-juice-sucrose medium was dextran with a peak molecular weight of 6.35 × 10(5)Da, a linear backbone composed of consecutive α-(1 → 6)-linked d-glucopyranosyl units and approximately 6% α-(1 → 3) branches. Copyright © 2014 Elsevier Ltd. All rights reserved.

Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration

Directory of Open Access Journals (Sweden)

Eun-Bin Bae

2018-01-01

Full Text Available This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL/β-tricalcium phosphate (β-TCP scaffold containing bone demineralized and decellularized extracellular matrix (bdECM and human recombinant bone morphogenetic protein-2 (rhBMP-2 on bone regeneration. Scaffolds were divided into PCL/β-TCP, PCL/β-TCP/bdECM, and PCL/β-TCP/bdECM/BMP groups. In vitro release kinetics of rhBMP-2 were determined with respect to cell proliferation and osteogenic differentiation. These three reconstructive materials were implanted into 8 mm diameter calvarial bone defect in male Sprague-Dawley rats. Animals were sacrificed four weeks after implantation for micro-CT, histologic, and histomorphometric analyses. The findings obtained were used to calculate new bone volumes (mm3 and new bone areas (%. Excellent cell bioactivity was observed in the PCL/β-TCP/bdECM and PCL/β-TCP/bdECM/BMP groups, and new bone volume and area were significantly higher in the PCL/β-TCP/bdECM/BMP group than in the other groups (p<.05. Within the limitations of this study, bdECM printed PCL/β-TCP scaffolds can reproduce microenvironment for cells and promote adhering and proliferating the cells onto scaffolds. Furthermore, in the rat calvarial defect model, the scaffold which printed rhBMP-2 loaded bdECM stably carries rhBMP-2 and enhances bone regeneration confirming the possibility of bdECM as rhBMP-2 carrier.

Assessment of a new interfacial friction correlation in TRAC-BD1/MOD1

International Nuclear Information System (INIS)

Analytis, G.T.

1986-01-01

Analysis of a number of 5-bar (and one 1-bar) boiloff experiments in the electrically heated 33-rod bundle NEPTUN at the Swiss Federal Institute for Reactor Research by TRAC-BD1 version 12 and MOD1 has shown that the code consistently underpredicts the collapsed liquid level histories, hence predicting earlier critical heat fluxes and higher peak rod surface temperatures than the measurements showed. Moreover, recent work has demonstrated that these differences can be attributed to the bubbly/churn interfacial friction model in TRAC-BD1 (resulting in rather large interfacial drag) whose appropriateness for rod bundles is questionable; decreasing the interfacial drag resulted in excellent agreement between measurements and code predictions. Recent analysis of boiloff experiments with the French code CATHARE and with a bubbly/churn interfacial drag force f/sub i/ similar to the one of TRAC-BD1 has also resulted in the underprediction of collapsed liquid level histories. In this work, it was shown that the usual vapor drift velocity correlations (through which f/sub i/ is derived) for this flow regime developed for tubes are not appropriate for rod bundles. Moreover, a new f/sub i/ correlation for bubbly/churn flow in rod bundles was developed based on the Froude number. The authors have modified this correlation slightly, implemented it in TRAC-BD1/MOD1, and reanalyzed most of the boiloff experiments in NEPTUN

Clinical and analytical performance of the BD Onclarity™ HPV assay for detection of CIN2+ lesions on SurePath samples

DEFF Research Database (Denmark)

Ejegod, Ditte Møller; Junge, Jette; Franzmann, Maria

2016-01-01

BACKGROUND: The novel BD Onclarity(TM) HPV assay (Onclarity) on the BD Viper™ LT system (BD Diagnostics, Sparks, MD), detects E6/E7 DNA from 13 high-risk HPV genotypes and HPV66. We compared the analytical and clinical performance of the Onclarity Assay to that of Hybrid Capture 2 and LINEAR ARRAY...

Energy efficiency in Germany - a meta-analysis. Analysis and recommendations; Energieeffizienz in Deutschland - eine Metastudie. Analyse und Empfehlungen

Energy Technology Data Exchange (ETDEWEB)

Bauernhansl, Thomas (ed.) [Stuttgart Univ. (Germany). Inst. fuer Energieeffizienz in der Produktion (EEP)

2014-07-01

The Stuttgart Institute of energy efficiency in production compiled the first meta-analysis ''Energy Efficiency in Germany''.It provides facts and figures on the development atatus and knowledge level of energy efficiency in Germany. The study shows the contribution have been made by individual measures and the potentials which are known, but have not yet been lifted. For this meta-analysis more than 250 items available from research institutions, government departments, professional and industry associations have been identified with the main topic of energy efficiency and evaluated. It provides an overview of the status of development and is an important reference work for industry, associations and politics. [German] Das Stuttgarter Institut fuer Energieeffizienz in der Produktion hat die erste Metastudie ''Energieeffizienz in Deutschland'' erarbeitet. Sie liefert Zahlen, Daten und Fakten zum Entwicklungs- und Kenntnisstand der Energieeffizienz in Deutschland. Die Studie zeigt auf, welchen Beitrag einzelne Massnahmen bisher geleistet haben und welche Potenziale zwar bekannt sind, aber bisher noch nicht gehoben wurden. Fuer diese Metastudie wurden mehr als 250 Veroeffentlichungen von Forschungseinrichtungen, Ministerien, Fach- und Industrieverbaenden mit Themenschwerpunkt Energieeffizienz identifiziert und ausgewertet. Sie bietet einen Ueberblick ueber den Stand der Entwicklung und ist ein wichtiges Nachschlagewerk fuer Industrie, Verbaende und Politik.

Bd0-bar Bd0 mixing and the prediction of the top-quark mass in an independent particle potential model

International Nuclear Information System (INIS)

Barik, N.; Das, P.; Panda, A.R.; Roy, K.C.

1993-01-01

Considering B d 0 -bar B d 0 mixing in a potential model of independent quarks by taking the effective interaction Hamiltonian of the standard Salam-Weinberg-Glashow model and subsequently diagonalizing the corresponding mass matrix with respect to B d 0 and bar B d 0 states, we obtain an expression for the mass difference ΔM Bd 0 in terms of the t-quark mass m t . Using the recent observation of the mixing parameter x d =0.72±0.15 by the ARGUS Collaboration, we predict the lower bound on the top-quark mass as m t ≥149 GeV. Further, a consideration of experimental mass difference ΔM Bd 0 =(4.0±0.8)x10 -13 GeV also leads to m t =167 -17 +16 GeV which is in agreement with the recent experimental bound as well as other theoretical predictions. However, such a prediction of m t that utilizes the experimental value of the CKM matrix element |V td | may not appear convincing in view of the large uncertainties in the measurement of |V td | so far reported. Therefore using the range of m t values within its bounds predicted from other independent works, we make a reasonable estimation of |V td |

Expression of human beta-defensins-1-4 in thyroid cancer cells and new insight on biologic activity of hBD-2 in vitro.

Science.gov (United States)

Zhuravel, O V; Gerashchenko, O L; Khetsuriani, M R; Soldatkina, M A; Pogrebnoy, P V

2014-09-01

The study was aimed on analysis of human beta-defensin-1-4 (hBDs) mRNA expression in cultured thyroid cancer cells and evaluation of effects of recombinant hBD-2 (rec-hBD-2) on growth patterns, migration properties and expression of E-cadherin and vimentin in these cells. The study was performed on cultured follicular thyroid cancer WRO cells, papillary thyroid cancer TPC1 cells, and anaplastic thyroid cancer KTC-2 cells. For analysis of hBD-1-4 mRNA expression in thyroid cancer cells, semiquantitative RT-PCR was used. Effects of rec-hBD-2 on cell proliferation, viability, and migration were analyzed using direct cell counting, MTT test, and scratch assay respectively. Expression of vimentin and E-cadherin was evaluated by quantitative PCR (qPCR). By the data of RT-PCR, all three studied thyroid cancer cell lines express hBD-1 and -4 mRNA, but not hBD-2 mRNA, while hBD-3 expression was detected in WRO and KTC-2 cells. The treatment of TPC-1, WRO, and KTC-2 cells with 100-1000 nM rec-hBD-2 resulted in significant concentration-dependent suppression of cell proliferation, viability, and migratory property. By the data of qPCR, significant up-regulation of vimentin expression was registered in KTC-2 and WRO cells treated with 500 nM rec-hBD-2. Significant down-regulation of E-cadherin expression (p cells treated with the defensin. Also, it has been shown that TPC-1 cells treated with 500 nM rec-hBD-2 acquired more elongated morphology. The data demonstrate that hBD-2 in concentrations higher than 100 nM exerts significant concentration-dependent suppression of thyroid cancer cell growth and migration, and affects vimentin and E-cadherin expression dependent on histologic type of thyroid cancer cells.

School Shootings in Deutschland: Aktuelle Trends zur Prävention von schwerer, zielgerichteter Gewalt an deutschen Schulen

OpenAIRE

Bondü, Rebecca; Scheithauer, Herbert

2009-01-01

Die School Shootings in Winnenden und Ansbach im März und September 2009 haben die Notwendigkeit präventiver Ansätze zur Vermeidung weiterer Taten in Deutschland erneut verdeutlicht. Aufgrund der geringen Häuigkeit des Phänomens und der geringen Speziität der bekannten Risikofaktoren ist eine gezielte Vorhersage und Prävention jedoch schwierig. Dennoch werden zurzeit verschiedene Präventionsansätze diskutiert. Der vorliegende Artikel stellt diese vor und beleuchtet ihre Vor- und Nachteile. Da...

17 CFR 249.618 - Form BD-Y2K, information required of broker-dealers pursuant to section 17 of the Securities...

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form BD-Y2K, information... Exchange Members, Brokers, and Dealers § 249.618 Form BD-Y2K, information required of broker-dealers... FR 37674, July 13, 1998] Editorial Note: For Federal Register citations affecting Form BD-Y2K, see...

Bibliothekarische Berufsethik in der Praxis – Ergebnisse eines Studienprojekts aus Deutschland und Großbritannien

Directory of Open Access Journals (Sweden)

Jens Boye

2011-10-01

Full Text Available Sowohl in Deutschland als auch in Großbritannien existieren seit einigen Jahren Grundsatzpapiere zur Berufsethik im Informations- und Bibliotheksbereich. Neben der bloßen Existenz derartiger Kodizes stellt sich die Frage, welche Relevanz diese Dokumente in der beruflichen Praxis haben. Dieser Frage wurde im Rahmen einer Team-Projektarbeit an der FH Köln nachgegangen. Mithilfe eines standardisierten Fragebogens wurden deutsche Bibliotheksleitungen zu der Thematik befragt. In Großbritannien wurde ein Interview mit Paul Sturges geführt, darüber hinaus erfolgte eine Analyse der Online-Angebote von CILIP, insbesondere des Information Ethics Blog.

checkCIF/PLATON report Datablock: monika-bd1re3

Indian Academy of Sciences (India)

IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: monika-bd1re3. Bond precision: C-C = 0.0046 A. Wavelength=0.71073.

Das Volkslied in Deutschland, Frankreich, Belgien und Holland. Untersuchungen über die Auffassung des Begriffes; Über die traditionellen Zeilen, die Zahlen-, Blumen- und Farbensymbolik

NARCIS (Netherlands)

Brouwer, Cornelis

1930-01-01

Wenn man die gewaltige Menge Publikationen über das Volkslied, die im Laufe des 19. und 20. Jahrhunderts in Deutschland, Frankreich, Belgien und Holland erschienen sind, vergleicht, springen zwei Punkte sofort ins Auge: 1. der Unterschied zwischen den verschiedenen Auffassungen vom Begriff Volkslied

Effect of chloride substitution on the order–disorder transition in NaBH{sub 4} and Na{sup 11}BD{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Olsen, Jørn Eirik [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Karen, Pavel [University of Oslo, Department of Chemistry, P.O. Box 1033 Blindern, NO-0315 Oslo (Norway); Sørby, Magnus H. [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Hauback, Bjørn C., E-mail: bjorn.hauback@ife.no [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway)

2014-02-25

Graphical abstract: Interactions that order the BD{sub 4}{sup -} tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH{sub 4}){sub 1−x}Cl{sub x} and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na{sup 11}BD{sub 4} at room temperature and 8 K and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na{sup 11}BD{sub 4} (NaBH{sub 4}) and its solid solutions with NaCl, Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x}, is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na{sup 11}BD{sub 4}, ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na{sup 11}BD{sub 4}) at 8 K.

驯鹿β-防御素-1(reBD-1)mRNA在驯鹿组织器官中的表达检测%The examination of expression of Reindeer β - defensin reBD - 1 mRNA in the tissues

Institute of Scientific and Technical Information of China (English)

吴萨日娜; 赵艳芳; 余兴帮; 都格尔斯仁; 杨银凤

2006-01-01

为了检测reBD-1 mRNA在驯鹿体内可能的表达器官,研究根据已知的reBD-1 cDNA序列设计了一对预计扩增产物为121 bp的引物,以驯鹿舌、食管、瘤胃、网胃、皱胃、十二指肠、回肠、结肠、肝、肺、气管、肾、膀胱、睾丸、附睾、心脏、脾脏中提取的总RNA为模板,采用反转录PCR(RT-PCR)技术检测驯鹿的上述器官内reBD-1 mRNA的表达情况.结果显示:reBD-1 mRNA在上述组织器官中均有表达,其中在舌、瘤胃、睾丸中表达最强;在食管、十二指肠、结肠、气管、脾脏中有中等量的表达;在网胃、皱胃、回肠、肝、肺、肾、膀胱、附睾、心脏内的表达较弱.β-防御素reBD-1在驯鹿体内的广泛表达提示reBD-1有助于驯鹿的先天性宿主防御.

Rapid Detection of Staphylococcus aureus and Methicillin-Resistant S. aureus in Atopic Dermatitis by Using the BD Max StaphSR Assay.

Science.gov (United States)

Lee, Mi Kyung; Park, Kui Young; Jin, Taewon; Kim, Ju Hee; Seo, Seong Jun

2017-07-01

Eczematous lesions of atopic dermatitis (AD) patients are known to be a source of Staphylococcus aureus (SA) transmission and might be a reservoir for community-associated methicillin-resistant SA (MRSA). The BD Max StaphSR (BD-SR) is a fully automated, multiplex real-time PCR assay for the direct detection and differentiation of SA and MRSA from nasal swab samples. We evaluated the detection rates of SA and MRSA from skin lesions of outpatients with AD using the BD-SR assay, and determined the usefulness of the BD-SR assay. A total of 244 skin swab samples (skin lesions of 213 outpatients with AD and normal skin of 31 healthy controls) were tested directly by using the BD-SR assay. Of the 213 samples from patients with AD, 69 (32.4%) were positive for SA, 6 (8.7%) of which were positive for MRSA. Only 1 (3.2%) of 31 samples from healthy controls was positive for SA. The BD-SR assay is effective for the rapid detection of SA and MRSA from skin swab samples, which can provide important information for managing patients with AD and preventing the spread of MRSA. © The Korean Society for Laboratory Medicine.

An investigation of Bd0 and Bs0 oscillation

Science.gov (United States)

Buskulic, D.; de Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Minard, M.-N.; Odier, P.; Pietrzyk, B.; Ariztizabal, F.; Comas, P.; Crespo, J. M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Gaitan, V.; Garrido, Ll.; Martinez, M.; Mattison, T.; Orteu, S.; Pacheco, A.; Padilla, C.; Pascual, A.; Creanza, D.; de Palma, M.; Farilla, A.; Iaselli, G.; Maggi, G.; Marinelli, N.; Natali, S.; Nuzzo, S.; Ranieri, A.; Raso, G.; Romano, F.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Zito, G.; Chai, Y.; Hu, H.; Huang, D.; Huang, X.; Lin, J.; Wang, T.; Xie, Y.; Xu, D.; Xu, R.; Zhang, J.; Zhang, L.; Zhao, W.; Bonvicini, G.; Boudreau, J.; Casper, D.; Drevermann, H.; Forty, R. W.; Ganis, G.; Gay, C.; Girone, M.; Hagelberg, R.; Harvey, J.; Hilgart, J.; Jacobsen, R.; Jost, B.; Knobloch, J.; Lehraus, I.; Maggi, M.; Markou, C.; Mato, P.; Meinhard, H.; Minten, A.; Miquel, R.; Moser, H.-G.; Palazzi, P.; Pater, J. R.; Perlas, J. A.; Perrodo, P.; Pusztaszeri, J.-F.; Ranjard, F.; Rolandi, L.; Rothberg, J.; Ruan, T.; Saich, M.; Schlatter, D.; Schmelling, M.; Sefkow, F.; Tejessy, W.; Tomalin, I. R.; Veenhof, R.; Wachsmuth, H.; Wasserbaech, S.; Wiedenmann, W.; Wildish, T.; Witzeling, W.; Wotschack, J.; Ajaltouni, Z.; Bardadin-Otwinowska, M.; Barres, A.; Boyer, C.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michael, B.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Saadi, F.; Fearnley, T.; Hansen, J. B.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Johnson, S. D.; Møllerud, R.; Nilsson, B. S.; Kyriakis, A.; Simopoulou, E.; Siotis, I.; Vayaki, A.; Zachariadou, K.; Badier, J.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Bourdon, P.; Fouque, G.; Passalacqua, L.; Rougé, A.; Rumpf, M.; Tanaka, R.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Veitch, E.; Focardi, E.; Moneta, L.; Parrini, G.; Corden, M.; Delfino, M.; Georgipoulos, C.; Jaffe, D. E.; Levinthal, D.; Antonelli, A.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Cerutti, F.; Chiarella, V.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Pepe-Altarelli, M.; Salomone, S.; Colrain, P.; Ten Have, I.; Knowles, I. G.; Lynch, J. G.; Maitland, W.; Morton, W. T.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Smith, M. G.; Thompson, A. S.; Thorn, S.; Turnbull, R. M.; Brandl, B.; Braun, O.; Geweniger, C.; Hanke, P.; Hepp, V.; Kluge, E. E.; Maumary, Y.; Putzer, A.; Rensch, B.; Stahl, A.; Tittel, K.; Wunsch, M.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Cattaneo, M.; Colling, D. J.; Dornan, P. J.; Hassard, J. F.; Lieske, N. M.; Moutoussi, A.; Nash, J.; Patton, S.; Payne, D. G.; Phillips, M. J.; San Martin, G.; Sedgbeer, J. K.; Wright, A. G.; Girtler, P.; Kuhn, D.; Rudolph, G.; Vogl, R.; Bowdery, C. K.; Brodbeck, T. J.; Finch, A. J.; Foster, F.; Hughes, G.; Jackson, D.; Keemer, N. R.; Nuttall, M.; Patel, A.; Sloan, T.; Snow, S. W.; Whelan, E. P.; Galla, A.; Greene, A. M.; Kleinknecht, K.; Raab, J.; Renk, B.; Sander, H.-G.; Schmidt, H.; Walther, S. M.; Wanke, R.; Wolf, B.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Calvet, D.; Carr, J.; Coyle, P.; Diaconu, C.; Drinkard, J.; Etienne, F.; Nicod, D.; Payre, P.; Roos, L.; Rousseau, D.; Schwemling, P.; Talby, M.; Adlung, S.; Assmann, R.; Bauer, C.; Blum, W.; Brown, D.; Cattaneo, P.; Dehning, B.; Dietl, H.; Dydak, F.; Frank, M.; Halley, A. W.; Jakobs, K.; Lauber, J.; Lütjens, G.; Lutz, G.; Männer, W.; Richter, R.; Schröder, J.; Schwarz, A. S.; Settles, R.; Seywerd, H.; Stierlin, U.; Stiegle, U.; St. Denis, R.; Wolf, G.; Alemany, R.; Boucrot, J.; Callot, O.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Janot, P.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Musolino, G.; Schune, M.-H.; Veillet, J.-J.; Videau, I.; Abbaneo, D.; Bagliesi, G.; Batignani, G.; Bottigli, U.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; Ciulli, V.; Dell'Orso, R.; Ferrante, I.; Fidecaro, F.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Mannelli, E. B.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Rizzo, G.; Sanguinetti, G.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Triggiani, G.; Valassi, A.; Vannini, C.; Venturi, A.; Verdini, P. G.; Walsh, J.; Betteridge, A. P.; Gao, Y.; Green, M. G.; Johnson, D. L.; March, P. V.; Medcalf, T.; Mir, Ll. M.; Quazi, I. S.; Strong, J. A.; Bertin, V.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Haywood, S.; Edward, M.; Norton, P. R.; Thompson, J. C.; Bloch-Devaux, B.; Colas, P.; Duarte, H.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Marx, B.; Perez, P.; Rander, J.; Renardy, J.-F.; Rosowsky, A.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Si Mohand, D.; Vallage, B.; Johnson, R. P.; Litke, A. M.; Taylor, G.; Wear, J.; Babbage, W.; Booth, C. N.; Buttar, C.; Cartwright, S.; Combley, F.; Dawson, I.; Thompson, L. F.; Barberio, E.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Lutters, G.; Rivera, F.; Schäfer, U.; Smolik, L.; Bosisio, L.; Della Marina, R.; Giannini, G.; Gobbo, B.; Pitis, L.; Ragusa, F.; Bellantoni, L.; Chen, W.; Chen, W.; Conway, J. S.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; Grahl, J.; Harton, J. L.; Hayes, O. J.; Nachtman, J. M.; Pan, Y. B.; Saadi, Y.; Schmitt, M.; Scott, I.; Sharma, V.; Shi, Z. H.; Turk, J. D.; Walsh, A. M.; Weber, F. V.; Sau Lan Wu; Wu, X.; Zheng, M.; Zobernig, G.; Aleph Collaboration

1994-02-01

B 0overlineB0 oscillation is studied using almost a million hadronic Z decays collected by the ALEPH experiment at LEP. Events are selected with two leptons present, on opposite sides of the event and with high transverse momentum. The leptons are expected to be dominantly from b decays; a topological vertexing technique is applied to measure the decay length of the b hadrons, and their momentum is determined using an energy-flow method. The fraction of events in which the leptons have the same charge is studied as a function of the measured decay time, and clear evidence is seen for the time-dependent nature of B d0overlineBd0 mixing. The frequency measured for the oscillation corresponds to a mass difference for the Bd0 mass eigenstates Δmd = (3.3 -0.4+0.5 ± 0.7) × 10 -4 eV/ c2. Allowing a second frequency component for the Bs0 a high value for Δms is favoured, leading to the limit Δms > 12 × 10 -4 eV/ c2 (95% CL), from which ( Δm/ Γ) s > 2.0 is derived.

A standardized CT/HRCT classification for occupational and environmental lung diseases of the German Federal Republic; Standardisierte CT/HRCT-Klassifikation der Bundesrepublik Deutschland fuer arbeits- und umweltbedingte Thoraxerkrankungen

Energy Technology Data Exchange (ETDEWEB)

Hering, K.G. [Radiologische Klinik, Knappschaftskrankenhaus Dortmund (Germany); Tuengerthal, S. [Roentgenabteilung, Thoraxklinik Heidelberg (Germany); Kraus, T. [Institut fuer Arbeitsmedizin, Universitaetsklinikum Aachen (Germany)

2004-05-01

unerlaesslicher Bestandteil der Diagnostik von Staublungenerkrankungen und anderen Inhalationsschaeden. Konsensfaehige Vereinbarungen ueber eine standardisierte Untersuchungstechnik und einheitliche Befundung existierten bislang aber nicht. Von der Arbeitsgemeinschaft ''Diagnostische Radiologie bei arbeits- und umweltbedingten Erkrankungen'' der Deutschen Roentgengesellschaft (DRG) wurde ein CT-Beurteilungsbogen eingesetzt, der auf Erfahrungen aus gutachtlichen Stellungnahmen, arbeitsmedizinischen nachgehenden Untersuchungen und Fortbildungskursen basiert und im Rahmen einer Multicenterstudie eingesetzt wurde. Ein weiter entwickeltes Schema einer internationalen Arbeitsgruppe (P.A. Gevenois, Belgien; K.G. Hering, T. Kraus, S. Tuengerthal, Deutschland; L. Kivisaari, T. Vehmas, Finnland; M. Letourneux, Frankreich; M.D. Crane, Grossbritannien; H. Arikawa, Y. Kusaka, N. Suganuma, Japan; J. Parker, USA) wurde international getestet. Es soll dazu dienen, die computertomographische Befundung der arbeits- und umweltbedingten Lungen- und Pleuraveraenderungen zu standardisieren und international Vergleiche zu ermoeglichen. Mit Hilfe von CT/HRCT-Referenzfilmen konnte diese reproduzierbare Vergleichbarkeit erreicht werden. Das Klassifizierungsschema hat einen rein deskriptiven Charakter, sodass alle Aspekte arbeits- und umweltbedingter Folgeerscheinungen an Parenchym und Pleura erfasst werden koennen. Obwohl einige der deskriptiven Bezeichnungen mit pneumokoniotischen Befunden verknuepft sind, wie z. B. rundliche Herde mit der Silikose oder interlobulaere septale und intralobulaere nichtseptale Linien sowie ''honeycombing'' mit der Asbestose, finden sich zahlreiche ueberlappende Bildmuster, die differenzialdiagnostisch zu diskutieren sind. (orig.)

Einige Gesichtspunkte der Handelsbeziehungen zwischen Sozialistischer Republik Rumänien und Bundesrepublik Deutschland (1960-1990

Directory of Open Access Journals (Sweden)

Lucian Fedor

2011-07-01

Full Text Available After the establishment of the first transactions of import and export from machines-building industry and food industry in the late 50’s, the economic and commercial relations between Socialist Romania and West Germany had a special evolution both at institutional and financial level in the 7-th and 8-th decades. The bilateral trade relations were characterized by structural asymmetry of the trade, long-term inequity interchange, Romanian exports dominated by products of light-industry and West-German exports dominated by heavy-industry products. The Federal Republic of Germany was for Romania the most important West European economic partner, with a decisive role in the industrialization and economic growth of our country in the 60’s and 70’s.

Research in the Federal Republic of Germany. Forschung in der Bundesrepublik Deutschland. Beispiele, Kritik, Vorschlaege

Energy Technology Data Exchange (ETDEWEB)

Schneider, C.

1983-01-01

This book is about research and, consequently, researchers. It shows the kinds of questions they ask themselves, how they solve them and how they use the results. A great deal of discussion is going on about research in the Federal Republic of Germany: the aims, the promotion measures, the quality of research by international standards and the yield in proportion to the expenditure. Are we doing enough research. What inner and outer conditions will best ensure the prosperity of research. This book is a plausible attempt to provide the discussion with a solid basis: in it scientists report their experiences, presenting, in a manner of speaking, a piece of their scientific autobiography, because that is most likely to throw a light on the multifariousness, complexity and, often enough, unpredictability of events, influences, thoughts and motives which finally bring about their scientific achievement in the form of results and effects. This book has the merit of giving a voice to men of the arts and of the sciences and to the engineering community as well. Successful research, today, always carries an aspect of associating diverging scientific domains. Yet it does not try to give a comprehensive view of research in the Federal Republic of Germany, but limits itself instead to examples. Each of them is illustrative in a particular way. In their totality, they convey a unique picture of the scientific culture of the present.

TRAC-BD1: transient reactor analysis code for boiling-water systems

International Nuclear Information System (INIS)

Spore, J.W.; Weaver, W.L.; Shumway, R.W.; Giles, M.M.; Phillips, R.E.; Mohr, C.M.; Singer, G.L.; Aguilar, F.; Fischer, S.R.

1981-01-01

The Boiling Water Reactor (BWR) version of the Transient Reactor Analysis Code (TRAC) is being developed at the Idaho National Engineering Laboratory (INEL) to provide an advanced best-estimate predictive capability for the analysis of postulated accidents in BWRs. The TRAC-BD1 program provides the Loss of Coolant Accident (LOCA) analysis capability for BWRs and for many BWR related thermal hydraulic experimental facilities. This code features a three-dimensional treatment of the BWR pressure vessel; a detailed model of a BWR fuel bundle including multirod, multibundle, radiation heat transfer, leakage path modeling capability, flow-regime-dependent constitutive equation treatment, reflood tracking capability for both falling films and bottom flood quench fronts, and consistent treatment of the entire accident sequence. The BWR component models in TRAC-BD1 are described and comparisons with data presented. Application of the code to a BWR6 LOCA is also presented

»Meine Tochter […] soll alles lernen, was die weissen Mädchen lernen…«. »Schwarze« Perspektiven auf Deutschland um 1900

Directory of Open Access Journals (Sweden)

Josch Lampe

2015-11-01

Full Text Available Der Artikel untersucht zwei gegensätzliche »schwarze« Perspektiven auf Deutschland um 1900. Ein Vergleich zwischen dem aus dem ehemaligen Deutsch-Südwestafrika stammenden Friedrich Maharero und dem Togolesen Nayo Bruce zeigt, inwiefern zwei unterschiedliche Standpunkte im kolonialen Kontext nicht nur die Umkehrperspektiven kolonialer Strukturen verdeutlichen, sondern in ihrer Verschiedenheit auch die Komplexität der Thematik darlegen.

Lightcurve Analysis for Near-Earth Asteroid (143404) 2003 BD44

Science.gov (United States)

Polakis, Tom; Warner, Brian D.; Skiff, Brian A.

2018-01-01

The synodic rotation period has been determined for the near-Earth asteroid (NEA) (143404) 2003 BD44. The asteroid was observed during three intervals with a rotation period on the order of 79 h determined in each case. The lightcurve exhibited rapidly changing morphology as the asteroid approached. Data have submitted to the ALCDEF database.

SUBSTELLAR-MASS COMPANIONS TO THE K-DWARF BD+14 4559 AND THE K-GIANTS HD 240210 AND BD+20 2457

International Nuclear Information System (INIS)

Niedzielski, A.; Nowak, G.; Adamow, M.; Wolszczan, A.

2009-01-01

We present the discovery of substellar-mass companions to three stars by the ongoing Penn State-Torun Planet Search conducted with the 9.2 m Hobby-Eberly Telescope. The K2-dwarf, BD+14 4559, has a 1.5 M J minimum mass companion with the orbital period of 269 days and shows a non-linear, long-term radial velocity (RV) trend, which indicates a possible presence of another planet-mass body in the system. The K3-giant, HD 240210, exhibits RV variations that require modeling with multiple orbits, but the available data are not yet sufficient to do it unambiguously. A tentative, one-planet model calls for a 5.2 M J minimum mass planet in a 502 day orbit around the star. The most massive of the three stars, the K2-giant, BD+20 2457, whose estimated mass is 2.8 ± 1.5 M sun , has two companions with the respective minimum masses of 21.4 M J and 12.5 M J and orbital periods of 380 and 622 days. Depending on the unknown inclinations of the orbits, the currently very uncertain mass of the star, and the dynamical properties of the system, it may represent the first detection of two brown dwarf-mass companions orbiting a giant. The existence of such objects will have consequences for the interpretation of the so-called brown dwarf desert known to exist in the case of solar-mass stars.

Photometric, Spectroscopic, and X-ray Analysis of the Cool Algol BD+05 706

Science.gov (United States)

Torres, G.; Mader, J.; Marschall, L. A.; Neuhaeuser, R.; Duffy, A. S.

2000-12-01

BD+05 706 is an example of a rare class of a dozen or so interacting binaries called ``cool Algols", in which both components of the system are late-type stars. By contrast, the ``classical Algols" are systems in which the star transfering mass is of late spectral type, but the mass gainer is much hotter. BD+05 706 was shown previously to be eclipsing (Marschall, Torres & Neuhaeuser 1998, BAAS, 30, 835). In this paper we report our complete analysis of BVRI light curves for the system obtained at Gettysburg College Observatory, together with spectroscopy from the Harvard-Smithsonian Center for Astrophysics reported previously (Torres, Neuhaeuser & Wichmann 1998, AJ, 115, 2028), and X-ray observations obtained with the ROSAT satellite. Our light curve analysis indicates the presence of spots, most likely on the more massive, active component (primary), which change from season to season. Our results confirm the semi-detached nature of the system, and combined with the spectroscopy they have allowed us to obtain the most precise absolute masses and radii for any object of this class. Our X-ray light curve for BD+05 706 shows the primary eclipse clearly, but no sign of a secondary eclipse, confirming that the primary is the active star. Strong X-ray flares are also visible.

Improved management of SG BD demineralizer for reduced generation of low-level radioactive spent resin in Korean nuclear power plants

International Nuclear Information System (INIS)

Rhee, I.; Cho, D.; Yeon, J.

2003-01-01

Most nuclear power plants in Korea have adopted Ethanolamine(ETA) as a secondary pH control agent to increase the pH at the liquid phase, which may reduce the corrosion in steam generator tubes and moisture separator/reheat system. Along with its beneficial effect of SG protection from corrosion and degradation, the replacement of ammonia with ETA causes the increased generation of spent resin and the reduced run time of demineralizer in steam generator blowdown(SG BD) system. The composition ratio of cation- to anion- exchange resin in SG BD mixed bed should be increased in the ETA chemistry environment to meet the ratio of cation to anion in the aqueous solution, which results in the simultaneous exhaustion of cation and anion exchange resins. The utilization rate of mixed bed is greatest at the cation-to-anion ratio of 95:1 on the theoretical equivalent basis in the solution, but practically highest at that of 22:1 due to the possible inhomogeneous distribution of cation and anion exchange resins in SG BD bed. The run time of the bed could be extended by 30% such that, at that much, the purchase cost of new resin is saved and the production rate of spent resin is reduced. The guideline on the replacement of resin in SG BD bed is not necessary to secure the removal of radioactive particles without the leakage of the primary coolant into the secondary side since all the radioactive ions can be eliminated by SG BD bed with the sufficient time. They are retained during more than one month after their ingress into the SG BD bed without leakage. With the reduced replacement, thus, the SG BD spent resin that comprises 65% of low-level radioactive solid waste can be much cut down

Label-free biochips for rapid detection of soybean allergen GlymBd ...

African Journals Online (AJOL)

detection. Keywords: Soybean Allergen, Gly mBd 30K, Biochip, Detection, Foods ... methods of choice by food industries and food .... shrimp, fish, peanut, wheat, and graham bread served as negative controls. Manufactured foods such as cream cake, cereal bar, chocolate biscuits, and pineapple cake were screened for.

Factors affecting the response of the bubble detector BD-100 and a comparison of its response to CR-39

International Nuclear Information System (INIS)

Ipe, N.E.; Busick, D.D.; Pollock, R.W.

1987-08-01

The BD-100 is a bubble detector available commercially from Chalk River Nuclear Laboratories, Canada for neutron dosimetry. According to the manufacturer, the BD-100 detects neutrons over an energy range of 100 keV to 14 MeV and the dose equivalent response is independent of energy. The sensitivity of the detector is dependent upon its temperature at the time of irradiation. The sensitized detector self-nucleates upon sharp impact and when heated to temperatures of 48 0 C or greater. The BD-100 is insensitive to low energy gamma rays but responds to 6 MeV photons. The sensitivity (bubbles/μSv) of the BD-100 was found to be energy dependent when exposed to standard neutron sources with average energies ranging from 0.5 to 4.5 MeV. The bubbles formed upon irradiation continued to grow in size with time. The response of electrochemically etched CR-39 to the same neutron sources is also reported for comparison

Photovoltaics in buildings. Final report; Photovoltaik in Gebaeuden. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Erge, T.; Hullmann, H.; Kaiser, R.; Kovach-Hebling, A.; Laukamp, H.; Reise, C.; Sauer, D.U.; Schmid, J.; Schmidt, H.; Sick, F.

1996-08-31

The feasibility in principle of photovoltaic plants integrated in buildings was proved in the 1980`s in the context of several pilot and demonstration projects both in Germany and internationally. However, the realisation and operation of these plants showed the necessity for further research and development work both in the system technique and particularly in the architectural area. The research project `Photovoltaics in buildings` reached the target of establishing a bridge between the technically orientated work of the researchers, developers and manufacturers of photovoltaic components on the one hand, and the architects and town planners on the other hand. (orig./AKF) [Deutsch] Die prinzipielle Machbarkeit gebaeudeintegrierter Photovoltaikanlagen wurde in den 80er Jahren im Rahmen mehrerer Pilot- und Demonstrationsprojekte sowohl in der Bundesrepublik Deutschland als auch international nachgewiesen. Die Realisierung und der Betrieb dieser Anlagen zeigte jedoch die Notwendigkeit weiterer Forschungs- und Entwicklungsarbeiten sowohl im systemtechnischen als insbesondere auch im architektonischen Bereich auf. Mit dem Forschungsprojekt `Photovoltaik in Gebaeuden` wurde das Ziel erreicht, eine Bruecke zu schlagen zwischen den eher technisch orientierten Arbeiten der Forscher, Entwickler und Hersteller von Photovoltaikkomponenten auf der einen Seite und den Architekten und Stadtplanern auf der anderen. (orig./AKF)

驯鹿β-防御素-1(reBD-1)基因在组织中表达的原位杂交检测%Detection of reindeer β-defensin-1 (reBD-1) gene's expression in tissues by in situ hybridization

Institute of Scientific and Technical Information of China (English)

杨银凤; 赵艳芳; 都格尔斯仁; 吴萨日娜

2007-01-01

β-防御素主要是由哺乳动物黏膜上皮细胞产生,分布在机体宿主-环境的界面位置.在本研究中,利用已克隆的驯鹿β-防御素reBD-1 cDNA作为探针,经地高辛标记后再应用原位杂交技术检测reBD-1 mRNA在驯鹿组织内的表达部位.结果显示reBD-1 mRNA表达在舌背表面的复层扁平上皮内,实质性器官肾也表达在肾小管及肾小囊上皮内,而淋巴器官脾脏内reBD-1 mRNA表达在淋巴细胞和红髓的巨噬细胞内.表明驯鹿β-防御素不仅表达在上皮细胞内,而且在非上皮细胞内也有表达,提示reBD-1在黏膜和系统防御中均起着重要的作用.

Overexpression of BdMATE Gene Improves Aluminum Tolerance in Setaria viridis

Directory of Open Access Journals (Sweden)

Ana P. Ribeiro

2017-06-01

Full Text Available Acidic soils are distributed worldwide, predominantly in tropical and subtropical areas, reaching around 50% of the arable soil. This type of soil strongly reduces crop production, mainly because of the presence of aluminum, which has its solubility increased at low pH levels. A well-known physiological mechanism used by plants to cope with Al stress involves activation of membrane transporters responsible for organic acid anions secretion from the root apex to the rhizosphere, which chelate Al, preventing its absorption by roots. In sorghum, a membrane transporter gene belonging to multidrug and toxic compound extrusion (MATE family was identified and characterized as an aluminum-activated citrate transporter gene responsible for Al tolerance in this crop. Setaria viridis is an emerging model for C4 species and it is an important model to validate some genes for further C4 crops transformation, such as sugarcane, maize, and wheat. In the present work, Setaria viridis was used as a model plant to overexpress a newly identified MATE gene from Brachypodium distachyon (BdMATE, closely related to SbMATE, for aluminum tolerance assays. Transgenic S. viridis plants overexpressing a BdMATE presented an improved Al tolerance phenotype, characterized by sustained root growth and exclusion of aluminum from the root apex in transgenic plants, as confirmed by hematoxylin assay. In addition, transgenic plants showed higher root citrate exudation into the rhizosphere, suggesting that Al tolerance improvement in these plants could be related to the chelation of the metal by the organic acid anion. These results suggest that BdMATE gene can be used to transform C4 crops of economic importance with improved aluminum tolerance.

[Protokolle der Estländischen Ritterschaft 1914-1920. Bd 1-2] / Mati Laur

Index Scriptorium Estoniae

Laur, Mati, 1955-

2012-01-01

Arvustus: Protokolle der Estländischen Ritterschaft 1914-1920. Bd. 1-2 (Ex fontibus archivi Estoniae, 3). Hrsg. von Thomas Freiherr von Dellingshausen und Henning von Wistingshausen. (Tartu: Eesti Ajalooarhiiv, 2011)

Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD and its association with theory of mind (ToM.

Directory of Open Access Journals (Sweden)

Agustin Ibanez

Full Text Available BACKGROUND: Adults with bipolar disorder (BD have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. METHODOLOGY/PRINCIPAL FINDINGS: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP assessment of a dual valence task (DVT, in which faces (angry and happy, words (pleasant and unpleasant, and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word and valence (positive vs. negative. All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word. BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG, including the face fusiform area (FFA. Neural generators of N170 for faces (FG and FFA were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind. CONCLUSIONS/SIGNIFICANCE: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.

Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM).

Science.gov (United States)

Ibanez, Agustin; Urquina, Hugo; Petroni, Agustín; Baez, Sandra; Lopez, Vladimir; do Nascimento, Micaela; Herrera, Eduar; Guex, Raphael; Hurtado, Esteban; Blenkmann, Alejandro; Beltrachini, Leandro; Gelormini, Carlos; Sigman, Mariano; Lischinsky, Alicia; Torralva, Teresa; Torrente, Fernando; Cetkovich, Marcelo; Manes, Facundo

2012-01-01

Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.

Vergleichende Untersuchungen zur Widerstandsfähigkeit von \\(\\textit {Apis mellifera}\\) gegenüber \\(\\textit {Varroa destructor}\\) in Deutschland und Südafrika

OpenAIRE

Bosch, Christoph (M. Sc.)

2016-01-01

Die Milbe \\(\\textit {Varroa destructor}\\) ist einer der bedeutendsten Parasiten der Westlichen Honigbiene \\(\\textit {Apis mellifera}\\). Mit der Ausbreitung entwickelten sich \\(\\it Varroa\\)-resistenzen bei Unterarten von \\(\\textit {A. mellifera}\\). In der vorliegenden Arbeit wurden ausgewählte Faktoren, die zur Widerstandsfähigkeit beitragen können, bei der anfälligen \\(\\textit {A. m. carnica}\\) in Deutschland und der resistenten \\(\\textit {A. m. scutellata}\\) in Südafrika untersucht. Dabei wu...

Oxoferryl-Porphyrin Radical Catalytic Intermediate in Cytochrome bd Oxidases Protects Cells from Formation of Reactive Oxygen Species*

Science.gov (United States)

Paulus, Angela; Rossius, Sebastiaan Gijsbertus Hendrik; Dijk, Madelon; de Vries, Simon

2012-01-01

The quinol-linked cytochrome bd oxidases are terminal oxidases in respiration. These oxidases harbor a low spin heme b558 that donates electrons to a binuclear heme b595/heme d center. The reaction with O2 and subsequent catalytic steps of the Escherichia coli cytochrome bd-I oxidase were investigated by means of ultra-fast freeze-quench trapping followed by EPR and UV-visible spectroscopy. After the initial binding of O2, the O–O bond is heterolytically cleaved to yield a kinetically competent heme d oxoferryl porphyrin π-cation radical intermediate (compound I) magnetically interacting with heme b595. Compound I accumulates to 0.75–0.85 per enzyme in agreement with its much higher rate of formation (∼20,000 s−1) compared with its rate of decay (∼1,900 s−1). Compound I is next converted to a short lived heme d oxoferryl intermediate (compound II) in a phase kinetically matched to the oxidation of heme b558 before completion of the reaction. The results indicate that cytochrome bd oxidases like the heme-copper oxidases break the O–O bond in a single four-electron transfer without a peroxide intermediate. However, in cytochrome bd oxidases, the fourth electron is donated by the porphyrin moiety rather than by a nearby amino acid. The production of reactive oxygen species by the cytochrome bd oxidase was below the detection level of 1 per 1000 turnovers. We propose that the two classes of terminal oxidases have mechanistically converged to enzymes in which the O–O bond is broken in a single four-electron transfer reaction to safeguard the cell from the formation of reactive oxygen species. PMID:22287551

Expression of beta-defensins pBD-1 and pBD-2 along the small tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection

NARCIS (Netherlands)

Veldhuizen, E.J.; Dijk, van A.; Tersteeg, M.H.; Kalkhove, S.I.; Meulen, van der J.; Niewold, T.A.; Haagsman, H.P.

2007-01-01

Defensins are antimicrobial peptides that play an important role in the innate immune response in the intestine. Up to date, only one ß-defensin (pBD-1), has been described in pig, which was found to be expressed at low levels in the intestine. We set-up a quantitative PCR method to detect the gene

Determinants of the distribution and concentration of biogas production in Germany. A spatial econometric analysis; Bestimmungsfaktoren der Verteilung und Konzentration der Biogasproduktion in Deutschland. Eine raeumlich-oekonometrische Analyse

Energy Technology Data Exchange (ETDEWEB)

Scholz, Lukas

2015-07-01

The biogas production in Germany is characterized by a heterogeneous distribution and the formation of regional centers. In the present study the determinants of the spatial distribution and concentration are analyzed with methods of spatial statistics and spatial econometrics. In addition to the consideration of ''classic'' site factors of agricultural production, the analysis here focuses on the possible relevance of agglomeration effects. The results of the work contribute to a better understanding of the regional distribution and concentration of the biogas production in Germany. [German] Die Biogasproduktion in Deutschland ist durch eine heterogene Verteilung und die Ausbildung von regionalen Zentren charakterisiert. In der vorliegenden Arbeit werden die Bestimmungsfaktoren der raeumlichen Verteilung und Konzentration mit Methoden der raeumlichen Statistik und der raeumlichen Oekonometrie analysiert. Neben der Betrachtung ''klassischer'' Standortfaktoren landwirtschaftlicher Produktion fokussiert die Analyse dabei auf die moegliche Relevanz von Agglomerationseffekten. Die Ergebnisse der Arbeit tragen zu einem besseren Verstaendnis der regionalen Verteilung und Konzentration der Biogasproduktion in Deutschland bei.

Final storage in Germany. Who is interested?; Endlagerung in Deutschland - Wer ist interessiert? Einige persoenliche Gedanken

Energy Technology Data Exchange (ETDEWEB)

Kuehn, K. [TU Clausthal (Germany). Inst. fuer Bergbau

2002-02-01

The final storage of radioactive waste and spent fuel in Germany - who, in Germany, has any interest in this subject, especially now that the new Atomic Energy Act has been adopted, and who is going to read this article? The author, Professor Klaus Kuehn, examines this question, analyzing in his contribution the current situation and the points of view of those who may be interested in this topic. In Prof. Kuehn's opinion, the addresses in particular are these: - the federal government, - the opposition in the federal parliament, - the federal states, - the Federal Ministry for the Environment, - the Federal Ministry for Research, - the Federal Ministry of Economics, - the Federal Office for Radiation Protection, - the operators of nuclear power plants, - the Working Group Elaborating Procedures for Selecting Repository Sites (AkEnd). Klaus Kuehn concludes that there is little interest at the present time in the subject of Final Storage in Germany, for reasons explained in detail which result both from the political constellation and from existing constraints. (orig.) [German] Die Endlagerung radioaktiver Abfaelle: 'Wer in Deutschland interessiert sich eigentlich fuer dieses Thema? Insbesondere jetzt, nach der Verabschiedung des neuen Atomgesetzes? Wer wird diesen Artikel lesen?' Der Autor, Professor Klaus Kuehn, geht dieser Fragestellung nach und analysiert in seinem Beitrag die Sachlage und Standpunkte der moeglichen potenziellen Interessenten an dieser Thematik. Im Einzelnen sind die betrachteten und aus Sicht von K. Kuehn entscheidenden Adressanten; - die Bundesregierung - die Opposition im Bundestag - die Bundeslaender - das Bundesumweltministerium - das Bundesforschungsministerium - das Bundeswirtschaftsministerium - das Bundesamt fuer Strahlenschutz - die Kernkraftwerksbetreiber - der Arbeitskreis Auswahlverfahren von Endlagerstandorten (AkEnd). Klaus Kuehn kommt zu dem Schluss, dass derzeit aus dezidiert dargelegten Gruenden, die sich sowohl

Comparison of the identification results of Candida species obtained by BD Phoenix™ and Maldi-TOF (Bruker Microflex LT Biotyper 3.1).

Science.gov (United States)

Marucco, Andrea P; Minervini, Patricia; Snitman, Gabriela V; Sorge, Adriana; Guelfand, Liliana I; Moral, Laura López

2018-02-05

In patients with invasive fungal infections, the accurate and rapid identification of the genus Candida is of utmost importance since antimycotic sensitivity is closely related to the species. The aim of the present study was to compare the identification results of species of the genus Candida obtained by BD Phoenix™ (Becton Dickinson [BD]) and Maldi-TOF MS (Bruker Microflex LT Biotyper 3.1). A total of 192 isolates from the strain collection belonging to the Mycology Network of the Autonomous City of Buenos Aires, Argentina, were analyzed. The observed concordance was 95%. Only 10 strains (5%) were not correctly identified by the BD Phoenix™ system. The average identification time with the Yeast ID panels was 8h 22min. The BD Phoenix™ system proved to be a simple, reliable and effective method for identifying the main species of the genus Candida. Copyright © 2017 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.

Assessment of TRAC-BD1/MOD1 using FIST data

International Nuclear Information System (INIS)

Jo, J.H.; Connell, H.R.

1985-01-01

This report is concerned with the assessment of the TRAC-BD1/MOD1 Code, developed at Idaho National Engineering Laboratory. The assessment was conducted using data from the FIST (Full Integral Simulation Test) facility, which is a BWR safety test facility which was built to investigate small break LOCA and operational transients in BWR's and to complement earlier large break LOCA test results from TLTA (Two-Loop Test Apparatus). 21 figs

One-electron oxidation of BD84, an ellipticine antitumor derivative

International Nuclear Information System (INIS)

Sekaki, A.; Gardes-Albert, M.; Houee-Levin, C.; Ferradini, C.; Rivalle, C.; Bisagni, E.; Hickel, B.

1991-01-01

The one-electron oxidation of BD84, an ellipticine-related drug, has been studied by pulse radiolysis using OH· radicals as oxidizing agents. In the absence of oxygen, R· radicals are formed. They disappear by recombination. In the presence of oxygen, R· radicals react with O 2 to give peroxy radicals RO 2 ·, which decay by a second-order process. These results are compared to those obtained for other ellipticine derivatives [fr

BD-22deg3467, a DAO-type Star Exciting the Nebula Abell 35

Science.gov (United States)

Ziegler, M.; Rauch, T.; Werner, K.; Koppen, J.; Kruk, J. W.

2013-01-01

Spectral analyses of hot, compact stars with non-local thermodynamical equilibrium (NLTE) model-atmosphere techniques allow the precise determination of photospheric parameters such as the effective temperature (T(sub eff)), the surface gravity (log g), and the chemical composition. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Aims. Previous spectral analyses of the exciting star of the nebula A35, BD-22deg3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. We aim to identify all observed lines in the ultraviolet (UV) spectrum of BD-22deg3467 and to determine the abundances of the respective species precisely. Methods. For the analysis of high-resolution and high signal-to-noise ratio (S/N) far-ultraviolet (FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. Results. The best agreement with the UV observation of BD-22deg3467 is achieved at T(sub eff) = 80 +/- 10 kK and log g = 7.2 +/- 0.3. While T(sub eff) of previous analyses is verified, log g is significantly lower. We re-analyzed lines of silicon and iron (1/100 and about solar abundances, respectively) and for the first time in this star identified argon, chromium, manganese, cobalt, and nickel and determined abundances of 12, 70, 35, 150, and 5 times solar, respectively. Our results partially agree with predictions of diffusion models for DA-type white dwarfs. A combination of photospheric and interstellar line-absorption models reproduces more than 90% of the observed absorption features. The stellar mass is M approx. 0.48 Solar Mass. Conclusions. BD.22.3467 may not have been massive enough to ascend the asymptotic giant branch and may have evolved directly from the extended horizontal branch

Long-term perspectives of technical and social development in Germany. Visions for research and technology policy; Langfristige Perspektiven technischer und gesellschaftlicher Entwicklung in Deutschland. Visionen fuer die Forschungs- und Technologiepolitik

Energy Technology Data Exchange (ETDEWEB)

Baron, W; Zweck, A

1995-12-01

This publication contains six contributions discussing the medium- and long-term perspectives of technical, social and economic development in Germany. (UA) [Deutsch] Die vorliegende Publikation enthaelt 6 Vortraege, die sich mit mittel- und langfristigen Perspektiven der technischen, sozialen und wirtschaftlichen Entwicklung in Deutschland befassen. (UA)

A dual mechanism involved in membrane and nucleic acid disruption of AvBD103b, a new avian defensin from the king penguin, against Salmonella enteritidis CVCC3377.

Science.gov (United States)

Teng, Da; Wang, Xiumin; Xi, Di; Mao, Ruoyu; Zhang, Yong; Guan, Qingfeng; Zhang, Jun; Wang, Jianhua

2014-10-01

The food-borne bacterial gastrointestinal infection is a serious public health threat. Defensins are evolutionarily conserved innate immune components with broad-spectrum antibacterial activity that do not easily induce resistance. AvBD103b, an avian defensin with potent activity against Salmonella enteritidis, was isolated from the stomach contents of the king penguin (Aptenodytes patagonicus). To elucidate further the antibacterial mechanism of AvBD103b, its effect on the S. enteritidis CVCC3377 cell membrane and intracellular DNA was researched. The cell surface hydrophobicity and a N-phenyl-1-naphthylamine uptake assay demonstrated that AvBD103b treatment increased the cell surface hydrophobicity and outer membrane permeability. Atomic absorption spectrometry, ultraviolet spectrophotometry, flow cytometry, and transmission electron microscopy (TEM) indicated that AvBD103b treatment can lead to the release of the cellular contents and cell death through damage of the membrane. DNA gel retardation and circular dichroism analysis demonstrated that AvBD103b interacted with DNA and intercalated into the DNA base pairs. A cell cycle assay demonstrated that AvBD103b affected cellular functions, such as DNA synthesis. Our results confirmed that AvBD103b exerts its antibacterial activity by damaging the cell membrane and interfering with intracellular DNA, ultimately causing cell death, and suggested that AvBD103b may be a promising candidate as an alternative to antibiotics against S. enteritidis.

Brachypodium distachyon line Bd3-1 resistance is elicited by the barley stripe mosaic virus triple gene block 1 movement protein

NARCIS (Netherlands)

Lee, M.Y.; Yan, L.J.; Gorter, F.A.; Kim, B.Y.T.; Cui, Y.; Hu, Y.; Yuan, C.; Grindheim, J.; Ganesan, U.; Liu, Z.Y.; Han, C.G.; Yu, J.L.; Li, D.W.; Jackson, A.O.

2012-01-01

Barley stripe mosaic virus North Dakota 18 (ND18), Beijing (BJ), Xinjiang (Xi), Type (TY) and CV21 strains are unable to infect the Brachypodium distachyon Bd3-1 inbred line, which harbours a resistance gene designated Bsr1, but the Norwich (NW) strain is virulent on Bd3-1. Analysis of ND18 and NW

Medical specialist attendance in nursing homes [Beschreibung und Bewertung der fachärztlichen Versorgung von Pflegeheimbewohnern in Deutschland

Directory of Open Access Journals (Sweden)

Balzer, Katrin

2013-04-01

Full Text Available [english] The care in nursing homes was examined based on scientific studies. The analysis focuses on dementia and type II diabetes. There is evidence for deficits in the supply of medical specialist attendance to nursing home residents with these diseases in Germany. Compared with corresponding guidelines the medical care for nursing home residents may be too low or inadequate.[german] Es wird die Versorgung in Pflegeheimen auf Basis wissenschaftlicher Studien untersucht. Schwerpunkte der Analyse sind Demenz und Diabetes. Es gibt Hinweise auf fachärztliche Versorgungsmängel bei Pflegeheimbewohnern mit diesen Krankheiten in Deutschland. Verglichen mit entsprechenden Leitlinien bestehen mögliche Unter- bzw. Fehlversorgungen.

Genital and extra-genital screening for gonorrhoea using the BD Probetec ET system with an in-house PCR method targeting the porA pseudogene as confirmatory test

DEFF Research Database (Denmark)

Skovgaard, Sissel; Larsen, Helle Kiellberg; Sand, Carsten

2012-01-01

for Chlamydia trachomatis testing were also examined for GC on the BD Viper™ platform using the BD Probetec ET system. In order to avoid false-positive results all GC BD reactive samples were re-tested using a PCR method with the porA pseudogene as target. Using this method we screened 170% more samples for GC...

Detection of Mycobacterium chelonae, Mycobacterium abscessus Group, and Mycobacterium fortuitum Complex by a Multiplex Real-Time PCR Directly from Clinical Samples Using the BD MAX System.

Science.gov (United States)

Rocchetti, Talita T; Silbert, Suzane; Gostnell, Alicia; Kubasek, Carly; Campos Pignatari, Antonio C; Widen, Raymond

2017-03-01

A new multiplex PCR test was designed to detect Mycobacterium chelonae, Mycobacterium abscessus group, and Mycobacterium fortuitum complex on the BD MAX System. A total of 197 clinical samples previously submitted for mycobacterial culture were tested using the new protocol. Samples were first treated with proteinase K, and then each sample was inoculated into the BD MAX Sample Buffer Tube. Extraction and multiplex PCR were performed by the BD MAX System, using the BD MAX ExK TNA-3 extraction kit and BD TNA Master Mix, along with specific in-house designed primers and probes for each target. The limit of detection of each target, as well as specificity, was evaluated. Of 197 clinical samples included in this study, 133 were positive and 60 were negative for mycobacteria by culture, and another 4 negative samples were spiked with M. chelonae ATCC 35752. The new multiplex PCR on the BD MAX had 97% concordant results with culture for M. abscessus group detection, 99% for M. chelonae, and 100% for M. fortuitum complex. The new multiplex PCR test performed on the BD MAX System proved to be a sensitive and specific test to detect M. chelonae, M. abscessus group, and M. fortuitum complex by real-time PCR on an automated sample-in results-out platform. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop.

Science.gov (United States)

Jagodnik, Kathleen M; Koplev, Simon; Jenkins, Sherry L; Ohno-Machado, Lucila; Paten, Benedict; Schurer, Stephan C; Dumontier, Michel; Verborgh, Ruben; Bui, Alex; Ping, Peipei; McKenna, Neil J; Madduri, Ravi; Pillai, Ajay; Ma'ayan, Avi

2017-07-01

The volume and diversity of data in biomedical research have been rapidly increasing in recent years. While such data hold significant promise for accelerating discovery, their use entails many challenges including: the need for adequate computational infrastructure, secure processes for data sharing and access, tools that allow researchers to find and integrate diverse datasets, and standardized methods of analysis. These are just some elements of a complex ecosystem that needs to be built to support the rapid accumulation of these data. The NIH Big Data to Knowledge (BD2K) initiative aims to facilitate digitally enabled biomedical research. Within the BD2K framework, the Commons initiative is intended to establish a virtual environment that will facilitate the use, interoperability, and discoverability of shared digital objects used for research. The BD2K Commons Framework Pilots Working Group (CFPWG) was established to clarify goals and work on pilot projects that address existing gaps toward realizing the vision of the BD2K Commons. This report reviews highlights from a two-day meeting involving the BD2K CFPWG to provide insights on trends and considerations in advancing Big Data science for biomedical research in the United States. Copyright © 2017 Elsevier Inc. All rights reserved.

Transparent thermal insulation for a fabrication hall of LHB, Salzgitter; Transparent gedaemmte Fertigungshalle bei LHB in Salzgitter

Energy Technology Data Exchange (ETDEWEB)

Galetzky, A. [Linke-Hofmann-Busch Waggon - Fahrzeug - Maschinen GmbH, Salzgitter (Germany); Goller, M. [Fraunhofer-Institut fuer Solare Energiesysteme (ISE), Freiburg im Breisgau (Germany)

1997-12-31

Many industrial workshops in Germany were erected during the 40s and 50s, especially at the beginning of the economic boom. After more than 40 years, these facilities are in need of structural and production-technical modernization. A case in point is the carriage fabrication workshop of the Salzgitter-based company Linke-Hoffmann-Busch. The characteristic features of this type of building are large glazed areas, free uncontrolled ventilation and substantial height. Opportunities for energy-oriented and light-technical modernization are demonstrated at this Salzgitter workshop in exemplary form, the emphasis being on the use of solar energy components and, particularly, transparent thermal insulation. (orig.) [Deutsch] In der Bundesrepublik Deutschland gibt es viele Produktionshallen, die in den vierziger und fuenfziger Jahren, insbesondere zu Beginn des wirtschaftlichen Aufschwungs, errichtet wurden. Diese Hallen sind nach ueber vierzig Jahren sowohl aus baulichen als auch produktionstechnischen Gruenden sanierungsbeduerftig. Die Halle 1, Waggonneubau, der Linke-Hofmann-Busch GmbH in Salzgitter ist ein typischer Vertreter dieser Art von Hallen. Sie zeichnen sich durch grosse Verglasungsflaechen, freie unkontrollierte Lueftung und relativ grosse Bauhoehe aus. Exemplarisch werden an dieser Halle Moeglichkeiten einer energetischen und lichttechnischen Sanierung aufgezeigt, wobei der Einsatz von Solarenergiekomponenten und insbesondere der Transparenten Waermedaemmung besondere Beruecksichtigung erfaehrt. (orig.)

Working Group for Water Pollution Abatement in the Weser River. Weser water quality report 2001; Arbeitsgemeinschaft zur Reinhaltung der Weser. Weserguetebericht 2001

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

The Weser is Germany's only river whose catchment area is entirely in Germany. This opens up interesting options in terms of water quality investigations, water protection measures, and river management. The ARGE Weser working group, which comprises the German states of Bremen, Hessen, Niedersachsen, Nordrhein-Westfalen and Thueringen, has been carrying out long-term measurements for many years in selected sites on the Werra, Fulda, Weser and Aller rivers. This report presents data, as well as information on the concentrations and action of the analyzed substances. It also presents an evaluation and assessment of the selected substances. [German] Das Einzugsgebiet der Weser befindet sich vollstaendig innerhalb der Bundesrepublik Deutschland. Im Vergleich zu anderen bedeutenden deutschen Flusseinzugsgebieten sind mit dieser Besonderheit aussergewoehnliche Moeglichkeiten verbunden. So koennen Gewaesseruntersuchungen, Gewaesserschutz und Bewirtschaftungsmassnahmen effektiv und ohne Hemmnisse durchgefuehrt und umgesetzt werden. Die Arbeitsgemeinschaft zur Reinhaltung der Weser (ARGE Weser), der die Bundeslaender Bremen, Hessen, Niedersachsen, Nordrhein-Westfalen und Thueringen angehoeren, fuehrt seit vielen Jahren an ausgewaehlten Standorten der Werra, Fulda, Weser und Aller Untersuchungen zur Wasserbeschaffenheit durch. Grundlage hierfuer ist das Messprogramm Weser. Der vorliegende Bericht versucht ueber die reine Zahlendokumentation hinaus auch ueber Vorkommen und Wirkungsweise der analysierten Stoffe zu informieren. Die Betrachtung der Messdaten beinhaltet eine Auswertung und Bewertung der ausgewaehlten und untersuchten Substanzen. (orig.)

A corpus-based analysis of textbooks used in the orientation course for immigrants in Germany: Ideological and pedagogic implications

Directory of Open Access Journals (Sweden)

Leung Ray C. H.

2016-09-01

Full Text Available Contextualized within immigrants’ acquisition of specialized knowledge about the host country at the institutional level, this article examines a 64295-word corpus of textbooks written for participants of the orientation course in German politics, history and culture. Corpus-based techniques (“keyness,” collocation and qualitative examination of concordance lines are deployed to explore the corpus. The findings reveal that the collocational patterns of the identified keywords construct particular world views vis-à-vis Germany. For instance, the keyword DDR [German Democratic Republic (GDR, aka East Germany] frequently co-occurs with negatively connoted lexis while collocates of the keywords denoting present-day Germany (e.g., Bundesrepublik Deutschland [Federal Republic of Germany] and Staat [nation, country, state] facilitate the portrayal of Germany as a nurturing welfare state that is popular among foreigners. It is argued that such discursively-construed opposition between the “bad” GDR and the “good” Federal Republic of Germany helps to legitimize the German reunification. Furthermore, it is found that certain keywords (e.g., Sie [you], Kurs [course, class] and z.B. [e.g.] are “metadiscourse resources” (Hyland, 2005. Their pedagogic effects are discussed in relation to the ideological implications of the research findings.

Reservoir patterns of soot, organic particles, total carbon, soluble substances and aerosols (numbers and mass) in the droplet and interstitial phase of clouds; Reservoiraufteilung von Russ, organischen Bestandteilen, Gesamtkohlenstoff, loeslichen Substanzen und Aerosolpartikeln (Anzahl und Masse) in der Tropfen- und Zwischenraumphase von Wolken. Abschlussbericht

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Wieprecht, W.; Acker, K.; Moeller, D.; Auel, R.; Hofmeister, J.; Kalass, D.

2002-07-01

The reservoir patterns of the constitutents of representative clouds over Germany were investigated for a better characterisation of their optical, microphysical and chemical properties. One of the key points of interest was the distribution of carbonaceous aerosol particles in the droplet and interstitial phase, which was to provide information on the role of absorbing (soot or BC) and organic carbon (OC) in cloud formation. Data about the effects of potential CCN on cloud characteristics and about the changes in aerosol particles induced by cloud processes are required as input for models of the chemical and climate effects of atmospheric aerosol. [German] Ziel des Projektes war eine moeglichst umfassende experimentelle Ermittlung der Reservoiraufteilung der Inhaltsstoffe repraesentativer Wolken ueber der Bundesrepublik Deutschland, um ihre optischen, mikrophysikalischen und chemischen Eigenschaften besser zu charakterisieren. Ein besonderer Schwerpunkt des Gesamtprojekts lag auf der Bestimmung der Verteilung kohlenstoffhaltiger Aerosolpartikel auf die Tropfen- und interstitielle Phase, um Aufschluesse ueber die Rolle von absorbierendem (Russ oder BC) und organischem Kohlenstoff (OC) bei der Wolkenbildung zu erhalten. Erkenntnisse sowohl ueber die Beeinflussung potentieller CCN auf Wolkeneigenschaften als auch ueber die Veraenderung der Aerosolpartikel durch Wolkenprozesse sind erforderlich als Eingangsdaten in entsprechende Modelle, um die chemischen und klimatischen Effekte des atmosphaerischen Aerosols zu bestimmen. (orig.)

Sex after Fascism. Sexualitätsgeschichte als Politikgeschichte? Sex after Fascism—The History of Sexuality as Political History?

Directory of Open Access Journals (Sweden)

Pascal Eitler

2006-03-01

Full Text Available Dagmar Herzog bietet mit der vorliegenden Untersuchung einen ersten und in diesem Sinne beachtenswerten, körper- und geschlechtergeschichtlich aber grundsätzlich ergänzungsbedürftigen Überblick zur Geschichte der Sexualität in Deutschland im 20. Jahrhundert. Im Zentrum der Studie steht das sich wandelnde Verhältnis zwischen Sexualität und Vergangenheitspolitik in der Bundesrepublik, insbesondere die Politisierung der Sexualität um ‚1968‘. Eher rückblickend geraten die Adenauerära und der Nationalsozialismus in den Blick. Der Titel der amerikanischen Originalausgabe bringt diesen Themenschwerpunkt deutlich zum Ausdruck: Sex after Fascism.Dagmar Herzog’s study offers a first and therefore noteworthy overview of the history of sexuality in twentieth-century Germany from the perspective of the history of the body and gender, a study that, however, is in need of supplementation. The central focus of the study is the changing relationship between sexuality and the politics of confronting the past in the Federal Republic of Germany. The book pays particular attention to the politicization of sexuality around 1968. The Adenauer-Era and National Socialism are, for the most part, attended to merely in retrospective. The title of the American original edition expresses this focus clearly: Sex after Fascism.

Production of oil and coke from sludges containing organic pollutants; Gewinnung von Oel und Koks aus organisch belasteten Schlaemmen

Energy Technology Data Exchange (ETDEWEB)

Steger, M [Martin Steger GmbH, Eggenfelden (Germany); Meissner, W; Herold, R [Max Aicher Umwelttechnik GmbH, Freilassing (Germany)

1998-09-01

Since the mid-eighties, Messrs. Max Aicher Umwelttechnik GmbH at Hammerau, Germany have been investigating sewage sludge pyrolysis. Laboratory experiments and semi-industrial investigations led to the construction of a combined sludge drying and conversion plant (``Aicher sludge recycling process``), in which the organic sludge fraction is converted into recyclable or combustible oils. Carbon is obtained as a by-product in solid form as conversion coke which can be utilized. Apart from sewage sludge, also industrial sludges with high organic fractions can be processed, e.g. sludges and sewage sludges from petroleum processing. (orig.) [Deutsch] In der Bundesrepublik Deutschland beschaeftigt sich die Max Aicher Umwelttechnik GmbH in Hammerau seit Mitte der Achtzigerjahre mit der Niedertemperaturkonvertierung (Pyrolyse) von Klaerschlamm. Versuche im Labor- und im halbtechnischen Massstab fuehrten zur Realisierung einer betriebstechnischen Anlage mit den Komponenten Schlammtrocknung und Konvertierung. Ziel des Aicher-Schlamm-Recycling-Verfahrens ist die Umwandlung der organischen Schlammfraktion in stofflich und energetisch verwertbare Oele. Bei der Umwandlung entsteht fixer Kohlenstoff, der im festen Rueckstand (Konversionskoks) angereichert wird. Neben dem gewonnenen Oel ist auch der produzierte Koks verwertbar. Einsatzstoffe fuer das Verfahren sind neben Klaerschlamm aus der kommunalen Abwasserreinigung vor allem industrielle Schlaemme mit hohen organischen Anteilen z.B. Schlaemme und Klaerschlaemme aus der Erdoelverarbeitung. (orig.)

Use of coal and coal exit in Germany from the perspective of the population; Kohlenutzung und Kohleausstieg in Deutschland aus Sicht der Bevoelkerung

Energy Technology Data Exchange (ETDEWEB)

Schumann, Diana; Fischer, Wolfgang; Hake, Juergen-Friedrich [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie- und Klimaforschung, Systemforschung und Technologische Entwicklung (IEK-STE)

2016-06-15

The objective of the energy policy to reduce greenhouse gas emissions by 2050 up to 80 to 95% compared to 1990, can be achieved only by a substantial decarbonisation of the energy production. For this purpose, in addition to the assessment of the technical and economic effects, information is necessary which views the population has use to coal and coal exit in Germany. Based on the results of a representative panel survey is first identified what citizens know about the use of coal, which attitudes they have and how they value the need for coal power plants. Then the awareness of the topic of coal exit in Germany, the understanding of the respondents, and the attitudes of the population to it will be illustrated. [German] Die Zielsetzung der Energiewende, die Treibhausgasemissionen bis zum Jahr 2050 um 80 bis 95 % gegenueber 1990 zu reduzieren, laesst sich nur durch eine weitgehende Dekarbonisierung der Energieerzeugung erreichen. Hierfuer sind neben der Abschaetzung der technischen und oekonomischen Auswirkungen auch Informationen darueber notwendig, welche Auffassungen die Bevoelkerung zur Kohlenutzung und zum Kohleausstieg in Deutschland hat. Anhand der Ergebnisse einer repraesentativen Panelbefragung wird zunaechst aufgezeigt, was Buergerinnen und Buerger ueber die Kohlenutzung wissen, welche Einstellungen sie dazu haben und wie sie die Notwendigkeit von Kohlekraftwerken bewerten. Anschliessend werden die Bekanntheit des Themas Kohleausstieg in Deutschland, das Verstaendnis der Befragten und die Einstellungen der Bevoelkerung zu diesem beleuchtet.

High level expression of human epithelial β-defensins (hBD-1, 2 and 3 in papillomavirus induced lesions

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Chong Kong T

2006-09-01

Full Text Available Abstract Background Epithelial defensins including human β-defensins (hBDs and α-defensins (HDs are antimicrobial peptides that play important roles in the mucosal defense system. However, the role of defensins in papillomavirus induced epithelial lesions is unknown. Results Papilloma tissues were prospectively collected from 15 patients with recurrent respiratory papillomatosis (RRP and analyzed for defensins and chemokine IL-8 expression by quantitative, reverse-transcriptase polymerase chain reaction (RT-PCR assays. HBD-1, -2 and -3 mRNAs were detectable in papilloma samples from all RRP patients and the levels were higher than in normal oral mucosal tissues from healthy individuals. Immunohistochemical analysis showed that both hBD-1 and 2 were localized in the upper epithelial layers of papilloma tissues. Expression of hBD-2 and hBD-3 appeared to be correlated as indicated by scatter plot analysis (r = 0.837, p Conclusion Human β-defensins are upregulated in respiratory papillomas. This novel finding suggests that hBDs might contribute to innate and adaptive immune responses targeted against papillomavirus-induced epithelial lesions.

Efficacy of shared decision-making on treatment adherence of patients with bipolar disorder: a cluster randomized trial (ShareD-BD).

Science.gov (United States)

Samalin, L; Honciuc, M; Boyer, L; de Chazeron, I; Blanc, O; Abbar, M; Llorca, P M

2018-04-13

Shared decision-making (SDM) is a model of interaction between doctors and patients in which both actors contribute to the medical decision-making process. SDM has raised great interest in mental healthcare over the last decade, as it is considered a fundamental part of patient-centered care. However, there is no research evaluating the efficacy of SDM compared to usual care (CAU), as it relates to quality of care and more specifically treatment adherence, in bipolar disorder (BD). This is a 12-month multi-centre, cluster-randomized controlled trial comparing the efficacy of SDM to CAU. Adult BD patients (n = 300) will be eligible after stabilization for at least 4 weeks following an acute mood episode. The intervention will consist of applying the standardized SDM process as developed by the Ottawa Hospital Research Institute in order to choose the maintenance treatment of BD. A multidisciplinary team developed a decision aid "choose my long-term treatment with my doctor" for BD patients to clarify possible therapeutic options. Primary outcome will assess the patient's level of adherence (based on hetero-evaluation) of ongoing treatment at 12 months. Secondary outcomes will assess the difference between the 2 groups of patients in terms of adherence to maintenance drug therapy based on other measures (self-assessment scale and plasma levels of mood stabilizers). Additionally, other dimensions will be assessed: decisional conflict, satisfaction with care and involvement in decision making, beliefs about treatment, therapeutic relationship, knowledge about information for medical decision and clinical outcomes (depression, mania, functioning and quality of life). The primary endpoint will be analysed without adjustment by comparison of adherence scores between the two groups using Student t-tests or Mann-Whitney tests according to the variable distribution. A set of secondary analyses will be adjusted for covariates of clinical interest using generalized linear

The cDNA Cloning and Sequencing of Reindeer β-defensin reBD-1%驯鹿β-防御素reBD-1 cDNA的克隆及序列分析

Institute of Scientific and Technical Information of China (English)

杨银凤; 赵艳芳; 余兴帮; 郝永峰

2006-01-01

从驯鹿舌黏膜上皮组织中提取总RNA,采用RT-PCR技术扩增出reBD-1的cDNA,并重组到pBlueselect T载体,经限制性内切酶谱分析和DNA序列测定,证实所克隆的reBD-1的cDNA为β-防御素,因为该cDNA包含由192个碱基组成的开放读码框(ORF),该ORF编码64个氨基酸残基的前原防御素,该前原防御素含有β-防御素特征性结构即6个在特定位置上的保守半胱氨酸残基.驯鹿β-防御素属首次发现,为更好地了解驯鹿黏膜防御机制有很大的帮助.

Markus Gamper: Islamischer Feminismus in Deutschland? Religiosität, Identität und Gender in muslimischen Frauenvereinen. Bielefeld: transcript Verlag 2011.

Directory of Open Access Journals (Sweden)

Charlotte Binder

2011-12-01

Full Text Available Anhand von qualitativen und quantitativen Daten wird in dieser soziologischen Studie die Bedeutung von Religiosität, Identität und Gender in muslimischen Frauenvereinen in Deutschland untersucht. Markus Gamper verknüpft die Ergebnisse mit den kulturtheoretischen Ansätzen von Stuart Hall und Homi K. Bhabha und vertritt die These, dass ein islamischer Feminismus in Deutschland existiere. Er stellt fest, dass es den in den Vereinen organisierten Frauen gelinge, Gegendiskurse zu der deutschen Mehrheitsgesellschaft sowie zu den androzentrisch geprägten muslimischen Gemeinschaften zu entwickeln und somit Widerstand gegen Diskriminierung zu leisten. Der Autor begegnet in den von ihm untersuchten Vereinen – statt ‚unterdrückten Muslima‘, wie sie von den Medien inszeniert werden – hochgebildeten Frauen, die selbstbewusst und unabhängig ein religiöses Leben führen.Using qualitative and quantitative data, this sociological study analyzes the meaning of religiosity, identity, and gender in Muslim women’s societies in Germany. Markus Gamper connects the findings to approaches from the field of cultural theory by Stuart Hall and Homi K. Bhabha. Furthermore, he advocates the proposition that Islamic feminism exists in Germany. He states that the women who are organized in these societies succeed in developing counter discourses to German mainstream society as well as to the androcentrically coined Muslim communities, thus, making a stand against discrimination. In the analyzed societies, the author encounters – instead of “suppressed Muslim women” as they are presented by the media – highly educated women, who, confidently and independently, lead a religious life.

La música gráfica de León Schidlowsky: Deutschland, ein Wintermárchen (1979 como partitura multimedial The Graphic Music of León Schidlowsky: Deutschland, ein Wintermárchen (1979 as a Multimedia Score

Directory of Open Access Journals (Sweden)

Daniela Fugellie Videla

2012-12-01

Full Text Available Este estudio aborda la música gráfica de León Schidlowsky (n. 1931, un género que el compositor cultivara mayoritariamente entre los años 1969 y 1984, inmediatamente tras su emigración desde Israel. Su propósito es presentar un panorama general del desarrollo del lenguaje gráfico del compositor y analizar algunos aspectos específicos de su obra Deutschland, ein Wintermárchen (1979, considerada por la autora como un punto culminante de dicho desarrollo. La investigación destaca la concepción multimedial de la obra, derivada de la técnica del collage, la cual logra sintetizar los diversos aspectos musicales, visuales y performativos, para obtener una visualización simultánea de un arte esencialmente temporal. Asimismo, el estudio profundiza en el contenido social y político de la obra. Postula finalmente que esta concepción heterogénea y multifacética es propia de un compositor transcultural, que transita libremente entre culturas y estéticas diversas.This paper deals with the graphic music ofLeón Schidlowsky (b.1931, a genre cultivated by the composermostly from 1969to 1984 afteremigratingfrom Chile to Israel. It presents a generalpanorama ofthe development ofthe graphical language ofthe composer, and analyzes some specific features of his work Deutschland, ein Wintermárchen (1979, considered by the author ofthe article as a culminating point of Schidlowsky's creative development. The research underlines the conception ofthis work as multimedia derived from the collage technique synthesizing the different musical, visual and performative aspects ofthe work into a simultaneous visualization ofwhat amounts to be an essentially temporal art. Besides, the study explores the social and political contents ofthe work, to conclude that this heterogeneous and multifarious conception is a natural feature of a transcultural composer, who moves freely among diverse cultures and aesthetics.

Jofre de Foixa, “Subrafusa ab cabirol” (BdT 304.4

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Wendy Pfeffer

2011-11-01

Full Text Available Jofre de Foixa’s verses “Subrafusa ab cabirol” (BdT 304.4 merit attention for the light the two ‘coblas’ shed on Jofre’s familiarity with his Occitan predecessors, for the information the text provides regarding food practices in his time, and for the use of a food term rare in the Iberian peninsula, “unyo”. The resources of culinary history, specifically fourteenth- and fifteenth-century Languedocian and Catalan cookbooks, allow us better to understand the meaning of Jofre’s lyric.

Glycoprotein from street rabies virus BD06 induces early and robust immune responses when expressed from a non-replicative adenovirus recombinant.

Science.gov (United States)

Wang, Shuchao; Sun, Chenglong; Zhang, Shoufeng; Zhang, Xiaozhuo; Liu, Ye; Wang, Ying; Zhang, Fei; Wu, Xianfu; Hu, Rongliang

2015-09-01

The rabies virus (RABV) glycoprotein (G) is responsible for inducing neutralizing antibodies against rabies virus. Development of recombinant vaccines using the G genes from attenuated strains rather than street viruses is a regular practice. In contrast to this scenario, we generated three human adenovirus type 5 recombinants using the G genes from the vaccine strains SRV9 and Flury-LEP, and the street RABV strain BD06 (nrAd5-SRV9-G, nrAd5-Flury-LEP-G, and nrAd5-BD06-G). These recombinants were non-replicative, but could grow up to ~10(8) TCID50/ml in helper HEK293AD cells. Expression of the G protein was verified by immunostaining, quantitative PCR and cytometry. Animal experiments revealed that immunization with nrAd5-BD06-G can induce a higher seroconversion rate, a higher neutralizing antibody level, and a longer survival time after rabies virus challenge in mice when compared with the other two recombinants. Moreover, the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly higher in mice immunized with nrAd5-BD06-G, which might also contribute to the increased protection. These results show that the use of street RABV G for non-replicative systems may be an alternative for developing effective recombinant rabies vaccines.

The Drosophila Gr28bD product is a non-specific cation channel that can be used as a novel thermogenetic tool.

Science.gov (United States)

Mishra, Aditi; Salari, Autoosa; Berigan, Benton R; Miguel, Kayla C; Amirshenava, Marzie; Robinson, Abbey; Zars, Benjamin C; Lin, Jenna L; Milescu, Lorin S; Milescu, Mirela; Zars, Troy

2018-01-17

Extrinsic control of single neurons and neuronal populations is a powerful approach for understanding how neural circuits function. Adding new thermogenetic tools to existing optogenetic and other forms of intervention will increase the complexity of questions that can be addressed. A good candidate for developing new thermogenetic tools is the Drosophila gustatory receptor family, which has been implicated in high-temperature avoidance behavior. We examined the five members of the Gr28b gene cluster for temperature-dependent properties via three approaches: biophysical characterization in Xenopus oocytes, functional calcium imaging in Drosophila motor neurons, and behavioral assays in adult Drosophila. Our results show that Gr28bD expression in Xenopus oocytes produces a non-specific cationic current that is activated by elevated temperatures. This current is non-inactivating and non-voltage dependent. When expressed in Drosophila motor neurons, Gr28bD can be used to change the firing pattern of individual cells in a temperature-dependent fashion. Finally, we show that pan-neuronal or motor neuron expression of Gr28bD can be used to alter fruit fly behavior with elevated temperatures. Together, these results validate the potential of the Gr28bD gene as a founding member of a new class of thermogenetic tools.

Development of renewable energy sources in Germany 2014. Charts and figures based on statistical data from the working group on renewable energy-statistics (AGEE-Stat); Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2014. Grafiken und Diagramme unter Verwendung aktueller Daten der Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat)

Energy Technology Data Exchange (ETDEWEB)

Nieder, Thomas; Bickel, Peter; Musiol, Frank (comps.) [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung Baden-Wuerttemberg (ZSW), Stuttgart (Germany)

2015-12-15

The more than 30 diagrams and graphs describe the development of the importance of renewable energy in Germany by the year 2014. Also, discusses the development of avoided greenhouse emissions through renewable energies, as well as the investments and their economic impulses for Germany. Some technical terms are conclusively explained in a glossary. [German] Die mehr als 30 Diagramme und Graphiken beschreiben die Entwicklung der Bedeutung der erneuerbaren Energien fuer Deutschland bis zum Jahr 2014. Auch wird auf die Entwicklung der vermiedenen Treibhaus-Emissionen durch erneuerbare Energien, sowie die Investitionen und deren wirtschaftlichen Impulse fuer Deutschland eingegangen. Einige Fachbegriffe werden abschliessend in einem Glossar erlaeutert.

Characterization of the cydAB-Encoded Cytochrome bd Oxidase from Mycobacterium smegmatis

Science.gov (United States)

Kana, Bavesh D.; Weinstein, Edward A.; Avarbock, David; Dawes, Stephanie S.; Rubin, Harvey; Mizrahi, Valerie

2001-01-01

The cydAB genes from Mycobacterium smegmatis have been cloned and characterized. The cydA and cydB genes encode the two subunits of a cytochrome bd oxidase belonging to the widely distributed family of quinol oxidases found in prokaryotes. The cydD and cydC genes located immediately downstream of cydB encode a putative ATP-binding cassette-type transporter. At room temperature, reduced minus oxidized difference spectra of membranes purified from wild-type M. smegmatis displayed spectral features that are characteristic of the γ-proteobacterial type cytochrome bd oxidase. Inactivation of cydA or cydB by insertion of a kanamycin resistance marker resulted in loss of d-heme absorbance at 631 nm. The d-heme could be restored by transformation of the M. smegmatis cyd mutants with a replicating plasmid carrying the highly homologous cydABDC gene cluster from Mycobacterium tuberculosis. Inactivation of cydA had no effect on the ability of M. smegmatis to exit from stationary phase at 37 or 42°C. The growth rate of the cydA mutant was tested under oxystatic conditions. Although no discernible growth defect was observed under moderately aerobic conditions (9.2 to 37.5 × 102 Pa of pO2 or 5 to 21% air saturation), the mutant displayed a significant growth disadvantage when cocultured with the wild type under extreme microaerophilia (0.8 to 1.7 × 102 Pa of pO2 or 0.5 to 1% air saturation). These observations were in accordance with the two- to threefold increase in cydAB gene expression observed upon reduction of the pO2 of the growth medium from 21 to 0.5% air saturation and with the concomitant increase in d-heme absorbance in spectra of membranes isolated from wild-type M. smegmatis cultured at 1% air saturation. Finally, the cydA mutant displayed a competitive growth disadvantage in the presence of the terminal oxidase inhibitor, cyanide, when cocultured with wild type at 21% air saturation in an oxystat. In conjunction with these findings, our results suggest that

Consensus on the back end of the fuel cycle urgently needed; Entsorgungskonsens dringend geboten

Energy Technology Data Exchange (ETDEWEB)

Strassburg, W. [RWE Energie AG, Essen (Germany). Zentralbereich Ausland - Politikanalysen

1996-05-01

The lack of harmonization among the fields of environmental policy, energy policy, and economic policy in Germany is obvious. Returning to a basic consensus in energy policy, with an unbiased evaluation of all energy resources, is an indispensable step for all those to whom ecology is a truly serious concept. The positions of all energy resources must be assessed with a view to national and international developments. No source of primary energy must be excluded from that review. Nuclear power remains one of the important options in the energy mix especially from the points of view of CO{sub 2} avoidance and preventive protection of the climate. A leading industrialized nation, such as the Federal Republic of Germany, ought to be able, in the more and more important discussion about globally sustainable development, to return to a consensus across all political parties at least about the back end of the nuclear fuel cycle. Or should the philosopher, Sir Karl Popper, finally be proven right in his statement that those wanting to establish a paradise on earth must be careful not to create hell? (orig.) [Deutsch] Der Abstimmungsmangel zwischen Umwelt-, Energie- und Wirtschaftspolitik in Deutschland ist unuebersehbar. Die Rueckkehr zum energiepolitischen Grundkonsens mit einer vorurteilsfreien Bewertung aller Energietraeger ist fuer solche, die es mit der Oekologie wirklich ernst meinen, unverzichtbar. Der Stellenwert aller Energietraeger muss im Hinblick auf nationale und internationale Entwicklungen ueberdacht werden; eine Tabuisierung einzelner Primaerenergietraeger darf es nicht geben. Insbesondere unter dem Aspekt der CO{sub 2}-Vermeidung und des vorsorgenden Klimaschutzes ist und bleibt die Kernenergie eine bedeutende Option im Energie-Mix. Im Rahmen der allgemein an Bedeutung gewinnenden Diskussion ueber eine global nachhaltige Entwicklung sollte es einer fuehrenden Industrienation wie der Bundesrepublik Deutschland eigentlich gelingen, zumindest hinsichtlich

ZWEI 'JAHRHUNDERTHOCHWASSER' IN ELF JAHREN - EIN VERGLEICH DER HOCHWASSEREREIGNISSE VON 2002 UND 2013 (IN DEUTSCHLAND

Directory of Open Access Journals (Sweden)

ANJA KLEINEBRAHN

2014-05-01

Full Text Available Zwei 'jahrhunderthochwasser' in elf jahren - ein vergleich der hochwasserereignisse von 2002 und 2013 (in Deutschland. Worldwide floods are among the most frequent and most momentous natural disasters. They occur in unpredictable intervals and dimensions and always bring particularly devastating or catastrophic impacts, if they get into contact with people or its uses. Within eleven years only Germany was affected of two so-called 'century-floods'. The expiry of extreme high water can be influenced by technical measures only up to a certain degree. It is therefore necessary to have a high protection from the effects of floods and to keep the impact as low as possible. Both being prepared as well as possible and being capable of acting for the case of emergency are corequisite. Flood protection is a longsome and s steadily continuing process. In dealing with the consequences of floods both political measures and the commitment and solidarity of the citizens were in demand.

Einstellung und Wissen von Lehramtsstudierenden zur Evolution - ein Vergleich zwischen Deutschland und der Türkei

Science.gov (United States)

Graf, Dittmar; Soran, Haluk

Es wird eine Untersuchung vorgestellt, in der Wissen und Überzeugungen von Lehramtsstudierenden aller Fächer zum Thema Evolution an zwei Universitäten in Deutschland und der Türkei erhoben worden sind. Die Befragung wurde in Dortmund und in Ankara durchgeführt. Es stellte sich heraus, dass ausgeprägte Defizite im Verständnis der Evolutionsmechanismen herrschen. Viele Studierende, insbesondere aus der Türkei, sind nicht von der Faktizität der Evolution überzeugt. Dies gilt sowohl für Studierende mit Fach Biologie als auch für Studierende mit anderen Fächern. Näher untersucht worden sind die Faktoren, die die Überzeugungen zur Evolution beeinflussen können, was ja in Anbetracht der hohen Ablehnungsrate der Evolution von besonderem Interesse ist. Das Vertrauen in die Wissenschaft spielt hierbei eine besondere Rolle: Wer der Wissenschaft vertraut, ist auch eher von der Evolution überzeugt, als diejenigen, die skeptisch gegenüber der Wissenschaft sind.

High Velocity Spectroscopic Binary Orbits from Photoelectric Radial Velocities: BD+20 5152, a Possible Triple System

Directory of Open Access Journals (Sweden)

Sperauskas J.

2010-12-01

Full Text Available The spectroscopic orbit of a high proper motion star, BD+20 5152, is calculated from 34 CORAVEL-type radial velocity measurements. The star has a slightly eccentric orbit with a period of 5.70613 d, half-amplitude of 47.7 km/s and eccentricity of 0.049. The center-of-mass velocity of the system is -24.3 km/s. BD+20 5152 seems to be a triple system consisting of a G8 dwarf as a primary component and of two K6-M0 dwarfs as secondary and tertiary components. This model is based on the analysis of its UBVRI and JHK magnitudes. According to the SuperWASP photometry, spots on the surface of the primary are suspected. The excessive brightness in the Galex FUV and NUV magnitudes and a non-zero eccentricity suggest the age of this system to be less than 1 Gyr.

The role of B/D ratio and A/D ratio to defferentiate malignancy from benignancy in distal extrahepatic bile duct obstruction

International Nuclear Information System (INIS)

Rhim, Hyun Chul; Baek, JUng Hwan; Jeon, Eui Yong; Koh, Byung Hee; Cho, On Koo; Kim, Young Hwan

1994-01-01

To determine wheter bilirubin/extrahepatic bile duct diameter ratio(B/D ratio) or alkalinephosphatase/extrahepatic bile duct diameter ratio (A/D ratio) can be used to differentiate malignant from benigndisease in distal extrahepatic bile duct obstruction during ultrasonographic examination. We retrospectively reviewed the sonograms and laboratory data of 100 patients with obstructive jaundice (benign : n=50, malignant: : n=50). The diagnosis was confirmed either surgically (n=66) or clinically (n=34). The B/D ratio and A/D radio were calculated by means of dividing total bilirubin (mg/dl) and alkaline phosphatase (I.U.)respectively by maximum extrahepatic bile duct diameter(mm) on ultrasonogram. Significant difference in B/D ratio was found between the benignancy (0.28+0.25) and malignancy (0.98+0.84) groups (P<0.001). Significant difference in A/D ratio was also found between the benignancy (15.00+10.22) and malignancy (32.44+30.28) groups(P<0.001) Accuracies to predict malignancy according to criteria of B/D and A/D ratios were less than 75% and 65%respectively. On the other hand, the positive predictive value and specificity were relatively high. The B/D ratio and A/D ratio calculated from ultrasonograms can be used as a valuable screening index todifferentiate malignancy from benignacy in patients with distal extrahepatic bile duct obstruction, especially when the sonography is difficult because of the interposition of bowel gas or obesity

The detection and differentiation of methicillin-resistant and methicillin-susceptible Staphylococcus aureus endocarditis by using the BD GeneOhm StaphSR Assay.

Science.gov (United States)

Frey, Amy B; Wilson, Deborah A; LaSalvia, Margaret M; Tan, Carmela D; Rodriguez, E Rene; Shrestha, Nabin K; Hall, Gerri S; Procop, Gary W

2011-11-01

We use the BD GeneOhm StaphSR Assay (BD Diagnostics, Oakville, Canada) to screen for Staphylococcus aureus nasal colonization and sought to evaluate this assay for the assessment of valve specimens from patients with endocarditis. We examined 23 paired fresh and formalin-fixed, paraffin-embedded cardiac valve tissue samples, 12 of which had S aureus endocarditis, using the BD GeneOhm StaphSR Assay for the detection and differentiation of methicillin-susceptible and methicillin-resistant S aureus. This assay appropriately characterized all specimens with respect to the presence or absence of S aureus. There was an 87.5% correlation between the presence or absence of the mecA gene and the oxacillin susceptibility results for the S aureus isolates studied. The GeneOhm StaphSR assay accurately detected S aureus in cardiac valve tissue samples. Rare discordances were observed between oxacillin susceptibility status and mecA gene detection by this assay.

Safe disposal of nuclear submarines of the Russian Federation. Final report on the German-Russian project. Reporting period: October 2003 - December 2016; Sichere Entsorgung von Atom-U-Booten der Russischen Foederation. Abschlussbericht ueber das Deutsch-Russische Projekt. Berichtszeitraum: Oktober 2003 - Dezember 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-07-01

As part of the ''Global Partnership Against the Proliferation of Weapons and Materials for Mass Destruction'' agreed by the G8 countries in June 2002, the Federal Republic of Germany has taken on the project ''Safe Disposal of Nuclear Submarines of the Russian Federation''. Following the conclusion of an intergovernmental agreement, project work began at the end of 2003 under the auspices of the Federal Ministry of Economics. At the end of 2016, this project of German-Russian cooperation could now be completed successfully, within the set financial and time frame. The final report documents the project goals, project organization as well as the task, work results and financial expenses of several sub-projects and summarizes the results of the overall project. [German] Im Rahmen der von den G8-Staaten im Juni 2002 vereinbarten ''Globalen Partnerschaft gegen die Verbreitung von Massenvernichtungswaffen und -materialien'' hat die Bundesrepublik Deutschland das Projekt ''Sichere Entsorgung von Atom-U-Booten der Russischen Foederation'' uebernommen. Nach Abschluss eines Regierungsabkommens begannen Ende 2003 unter der Federfuehrung des Bundeswirtschaftsministeriums die Projektarbeiten. Ende 2016 konnte dieses Projekt deutsch-russischer Kooperation nun vollumfaenglich, innerhalb des gesetzten Finanz- und Zeitrahmens erfolgreich abgeschlossen werden. Der Abschlussbericht dokumentiert die Projektziele, Projektorganisation sowie Aufgabenstellung, Arbeitsergebnisse und finanziellen Aufwendungen mehrerer Teilprojekte und fasst die Ergebnisse des Gesamtprojekts zusammen.

The Life Span of the BD-PND Bubble Detector

International Nuclear Information System (INIS)

Vanhavere, F.; Loos, M.; Thierens, H.

1999-01-01

BD-PND bubble detectors from Bubble Technology Industries (BTI) were used to conduct a study of the life span of these detectors. The manufacturer guarantees an optimum detector performance for three months after receipt. Nevertheless, it is important to know the evolution of their characteristics with time, also after those three months. On a standard set-up with a 252 Cf source the bubble detectors were irradiated until they reached the end of their life span. During this period, the evolution in sensitivity was monitored. The temperature compensating system seems to be the limiting factor with time for the use of the BTI bubble detectors. The change in temperature dependence with age was determined. The same parameters were also checked with several batches of detectors that were used in practice. (author)

Balance of plant modeling in TRAC-BD1/MOD1

International Nuclear Information System (INIS)

Weaver, W.L.; Giles, M.M.; Mohr, C.M.

1983-01-01

The mission of the TRAC-BD1/MOD1 code is to provide a best-estimate analysis capability for Boiling Water Reactor systems and related experimental facilities for the full range of accidents from large and small break Loss-of-Coolant accidents to operational transients including anticipated transients without scram (ATWS), for which point reactor kinetics is adequate (as a first approximation). Recent model developments allow a complete reactor system including the containment and the balance of plant to be modeled. This paper describes the balance of plant models and presents the results of a simulation of a loss-of-feedwater heater transients which was used to assess the performance of the balance of plant models

Schlechte Zeiten für Bildung: Globalisierung, Deregulierung und Privatisierung im Ländervergleich Türkei und Bundesrepublik Deutschland

Science.gov (United States)

Ügeöz, Perihan

1998-09-01

Because of the forced reductions in state activities that are observed worldwide as a result of the increasingly unrestricted growth of competition, national public institutions of education are under escalating pressure. Both in basic and in higher education, a creeping process of privatization is occurring, while more and more of the costs of education are being passed on to the citizen. This applies to both industrialized countries such as Germany, and to Turkey. The international dimension of this subversive process, which is also drastically affecting the prospects for academic research, is seldom critically addressed in eduational discourse. Instead, the field is dominated by a high-brow attitude to the globalization process which sees it as helping to promote world citizenship.

Rezension zu: Nina Bauer, Jens Luedtke (Hg.: Die soziale Konstruktion von Männlichkeit. Hegemoniale und marginalisierte Männlichkeiten in Deutschland. Opladen u.a.: Verlag Barbara Budrich 2008.

Directory of Open Access Journals (Sweden)

Katharina Pühl

2009-10-01

Full Text Available Der Band versammelt neuere, vorwiegend empirisch basierte Beiträge aus der Geschlechterforschung der Soziologie. Im Fokus stehen die Konstruktionsprozesse hegemonialer Männlichkeiten im Kontext gesellschaftlicher Transformationsprozesse in Deutschland. Forschungsperspektiven für zukünftige wissenschaftliche Studien werden benannt, allen voran die Notwendigkeit, in einem stärkeren Maße eine intersektionale Perspektive einzunehmen, die die Diskurse der kritischen feministischen Genderforschung noch mehr als bisher für die Männerforschung produktiv machen könnte.

An item response theory evaluation of the young mania rating scale and the montgomery-asberg depression rating scale in the systematic treatment enhancement program for bipolar disorder (STEP-BD).

Science.gov (United States)

Prisciandaro, James J; Tolliver, Bryan K

2016-11-15

The Young Mania Rating Scale (YMRS) and Montgomery-Asberg Depression Rating Scale (MADRS) are among the most widely used outcome measures for clinical trials of medications for Bipolar Disorder (BD). Nonetheless, very few studies have examined the measurement characteristics of the YMRS and MADRS in individuals with BD using modern psychometric methods. The present study evaluated the YMRS and MADRS in the Systematic Treatment Enhancement Program for BD (STEP-BD) study using Item Response Theory (IRT). Baseline data from 3716 STEP-BD participants were available for the present analysis. The Graded Response Model (GRM) was fit separately to YMRS and MADRS item responses. Differential item functioning (DIF) was examined by regressing a variety of clinically relevant covariates (e.g., sex, substance dependence) on all test items and on the latent symptom severity dimension, within each scale. Both scales: 1) contained several items that provided little or no psychometric information, 2) were inefficient, in that the majority of item response categories did not provide incremental psychometric information, 3) poorly measured participants outside of a narrow band of severity, 4) evidenced DIF for nearly all items, suggesting that item responses were, in part, determined by factors other than symptom severity. Limited to outpatients; DIF analysis only sensitive to certain forms of DIF. The present study provides evidence for significant measurement problems involving the YMRS and MADRS. More work is needed to refine these measures and/or develop suitable alternative measures of BD symptomatology for clinical trials research. Copyright © 2016 Elsevier B.V. All rights reserved.

75 FR 27406 - Airworthiness Directives; Bombardier, Inc. Model BD-100-1A10 (Challenger 300) Airplanes

Science.gov (United States)

2010-05-17

...., Monday through Friday, except Federal holidays. Examining the AD Docket You may examine the AD docket on....m. and 5 p.m., Monday through Friday, except Federal holidays. The AD docket contains this AD, the... BD-100-1A10 (Challenger 300) airplanes, having serial numbers (S/Ns) 20001 through 20274 inclusive...

Energy for Germany 2010. US energy policy; Energie fuer Deutschland 2010. Energiepolitik der USA

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-06-15

This is a publication of the Weltenergierat-Deutschland e.V. (World Energy Council), Berlin, dealing with US energy policy. In particular, it presents the energy-political boundary conditions and challenges, the energy policy of the USA and an outlook to the future: While Obama's energy policy is giving room for transatlantic cooperations, obstacles will remain. There is a chapter on energy and the world, which goes into the following issues: World Energy Outlook 2009 of the International Energy Agency (IEA); Copenhagen from thew view of the World Energy Council; Desertec; CCS implementation worldwide; ''Yasun: ITT'' - Ecuador. The chapter on energy in Europe discusses the following subjects: Priorities of the energy policy of the new EU Commission; EEX and coupling points; the third EU energy package for the internal market; Green power certificates (EWI study); Nuclear power: New power plant construction projects and operating times of existing powerplants in Europe; EU directive on gas supply reliability; Regional cooperations for assuring reliability of supply. The final chapter informs on energy in Germany: Long-term geological storage of CO2 in Germany; Electromobility; Vulnerability and reliability of supply as indicators of assured energy supply. (orig./RHM)

Energy for Germany 2010. US energy policy; Energie fuer Deutschland 2010. Energiepolitik der USA

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-06-15

This is a publication of the Weltenergierat-Deutschland e.V. (World Energy Council), Berlin, dealing with US energy policy. In particular, it presents the energy-political boundary conditions and challenges, the energy policy of the USA and an outlook to the future: While Obama's energy policy is giving room for transatlantic cooperations, obstacles will remain. There is a chapter on energy and the world, which goes into the following issues: World Energy Outlook 2009 of the International Energy Agency (IEA); Copenhagen from thew view of the World Energy Council; Desertec; CCS implementation worldwide; ''Yasun: ITT'' - Ecuador. The chapter on energy in Europe discusses the following subjects: Priorities of the energy policy of the new EU Commission; EEX and coupling points; the third EU energy package for the internal market; Green power certificates (EWI study); Nuclear power: New power plant construction projects and operating times of existing powerplants in Europe; EU directive on gas supply reliability; Regional cooperations for assuring reliability of supply. The final chapter informs on energy in Germany: Long-term geological storage of CO2 in Germany; Electromobility; Vulnerability and reliability of supply as indicators of assured energy supply. (orig./RHM)

The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity.

Directory of Open Access Journals (Sweden)

Marco Ventura

2009-12-01

Full Text Available Bifidobacteria, one of the relatively dominant components of the human intestinal microbiota, are considered one of the key groups of beneficial intestinal bacteria (probiotic bacteria. However, in addition to health-promoting taxa, the genus Bifidobacterium also includes Bifidobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. The genome of B. dentium Bd1, a strain isolated from dental caries, was sequenced to completion to uncover a single circular 2,636,368 base pair chromosome with 2,143 predicted open reading frames. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialized nutrient acquisition, defences against antimicrobials, and gene products that increase fitness and competitiveness within the oral niche. B. dentium Bd1 was shown to metabolize a wide variety of carbohydrates, consistent with genome-based predictions, while colonization and persistence factors implicated in tissue adhesion, acid tolerance, and the metabolism of human saliva-derived compounds were also identified. Global transcriptome analysis demonstrated that many of the genes encoding these predicted traits are highly expressed under relevant physiological conditions. This is the first report to identify, through various genomic approaches, specific genetic adaptations of a Bifidobacterium taxon, Bifidobacterium dentium Bd1, to a lifestyle as a cariogenic microorganism in the oral cavity. In silico analysis and comparative genomic hybridization experiments clearly reveal a high level of genome conservation among various B. dentium strains. The data indicate that the genome of this opportunistic cariogen has evolved through a very limited number of horizontal gene acquisition events, highlighting the narrow boundaries that separate commensals from

Hubble space telescope near-ultraviolet spectroscopy of the bright cemp-no star BD+44°493

International Nuclear Information System (INIS)

Placco, Vinicius M.; Beers, Timothy C.; Smith, Verne V.; Roederer, Ian U.; Cowan, John J.; Frebel, Anna; Filler, Dan; Ivans, Inese I.; Lawler, James E.; Schatz, Hendrik; Sneden, Christopher; Sobeck, Jennifer S.; Aoki, Wako

2014-01-01

We present an elemental-abundance analysis, in the near-ultraviolet (NUV) spectral range, for the extremely metal-poor star BD+44°493 a ninth magnitude subgiant with [Fe/H] =–3.8 and enhanced carbon, based on data acquired with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. This star is the brightest example of a class of objects that, unlike the great majority of carbon-enhanced metal-poor (CEMP) stars, does not exhibit over-abundances of heavy neutron-capture elements (CEMP-no). In this paper, we validate the abundance determinations for a number of species that were previously studied in the optical region, and obtain strong upper limits for beryllium and boron, as well as for neutron-capture elements from zirconium to platinum, many of which are not accessible from ground-based spectra. The boron upper limit we obtain for BD+44°493, log ε (B) <–0.70, the first such measurement for a CEMP star, is the lowest yet found for very and extremely metal-poor stars. In addition, we obtain even lower upper limits on the abundances of beryllium, log ε (Be) <–2.3, and lead, log ε (Pb) <–0.23 ([Pb/Fe] <+1.90), than those reported by previous analyses in the optical range. Taken together with the previously measured low abundance of lithium, the very low upper limits on Be and B suggest that BD+44°493 was formed at a very early time, and that it could well be a bona-fide second-generation star. Finally, the Pb upper limit strengthens the argument for non-s-process production of the heavy-element abundance patterns in CEMP-no stars.

The "Cool Algol" BD+05 706 : Photometric observations of a new eclipsing double-lined spectroscopic binary

Science.gov (United States)

Marschall, L. A.; Torres, G.; Neuhauser, R.

1998-05-01

BVRI Observations of the star BD+05 706, carried out between January, 1997, and April 1998 using the 0.4m reflector and Photometrics CCD camera at the Gettysburg College Observatory, show that the star is an eclipsing binary system with a light curve characteristic of a class of semi-detached binaries known as the "cool Algols". These results are in good agreement with the previous report of BD+05 706 as a cool Algol by Torres, Neuhauser, and Wichmann,(Astron. J., 115, May 1998) who based their classification on the strong X-ray emission detected by Rosat and on a series of spectroscopic observations of the radial velocities of both components of the system obtained at the Oak Ridge Observatory, the Fred L. Whipple Observatory, and the Multiple Mirror Telescope. Only 10 other examples of cool Algols are known, and the current photometric light curve, together with the radial velocity curves obtained previously, allows us to derive a complete solution for the physical parameters of each component, providing important constraints on models for these interesting systems.

VizieR Online Data Catalog: BD+46 442 optical spectra (Bollen+, 2017)

Science.gov (United States)

Bollen, D.; van Winckel, H.; Kamath, D.

2017-08-01

Reduced high-resolution (R~85000) optical spectra of BD+46 442. These 104 spectra were obtained between July 2009 and January 2016 from the HERMES spectrograph, mounted on the 1.2m Flemish Mercator telescope at La Palma, Canary Islands, Spain. The spectra cover a wavelength range from 3770 to 9000 angstrom in logscale. The flux is given in arbitrary units. The spectra are collected as FITS files. The numbering of the spectra corresponds to the numbering in Table B.1 in the article (e.g. spec_15.fits corresponds to N=15). (2 data files).

Jet creation in post-AGB binaries: the circum-companion accretion disk around BD+46°442

Science.gov (United States)

Bollen, Dylan; Van Winckel, Hans; Kamath, Devika

2017-11-01

Aims: We aim at describing and understanding binary interaction processes in systems with very evolved companions. Here, we focus on understanding the origin and determining the properties of the high-velocity outflow observed in one such system. Methods: We present a quantitative analysis of BD+46°442, a post-AGB binary that shows active mass transfer that leads to the creation of a disk-driven outflow or jet. We obtained high-resolution optical spectra from the HERMES spectrograph, mounted on the 1.2 m Flemish Mercator Telescope. By performing a time-series analysis of the Hα profile, we identified the different components of the system. We deduced the jet geometry by comparing the orbital phased data with our jet model. In order to image the accretion disk around the companion of BD+46°442, we applied the technique of Doppler tomography. Results: The orbital phase-dependent variations in the Hα profile can be related to an accretion disk around the companion, from which a high-velocity outflow or jet is launched. Our model shows that there is a clear correlation between the inclination angle and the jet opening angle. The latitudinally dependent velocity structure of our jet model shows a good correspondence to the data, with outflow velocities higher than at least 400 km s-1. The intensity peak in the Doppler map might be partly caused by a hot spot in the disk, or by a larger asymmetrical structure in the disk. Conclusions: We show that BD+46°442 is a result of a binary interaction channel. The origin of the fast outflow in this system might be to a gaseous disk around the secondary component, which is most likely a main-sequence star. Our analysis suggests that the outflow has a rather wide opening angle and is not strongly collimated. Our time-resolved spectral monitoring reveals the launching site of the jet in the binary BD+46°442. Similar orbital phase-dependent Hα profiles are commonly observed in post-AGB binaries. Post-AGB binaries provide ideal

13 CFR 124.203 - What must a concern submit to apply to the 8(a) BD program?

Science.gov (United States)

2010-01-01

... to, financial statements, Federal personal and business tax returns, and personal history statements... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What must a concern submit to apply to the 8(a) BD program? 124.203 Section 124.203 Business Credit and Assistance SMALL BUSINESS...

High-resolution 8-13 micron imaging of the planetary nebulae BD + 30 deg 3639 and NGC 6572

International Nuclear Information System (INIS)

Hora, J.L.; Hoffmann, W.F.; Deutsch, L.K.; Fazio, G.G.

1990-01-01

High-resolution midinfrared images of the planetary nebulae BD + 30 deg 3639 and NGC 6572 are presented at 8.3, 8.7, 9.8, 11.2, and 12.4 microns. Analysis of the maps of BD + 30 deg 3639 supports a model in which the infrared emission originates from two spatially distinct components, one which is responsible for the continuum radiation at 8-12 microns and the other which produces the emission-line features. The NGC 6572 images provides evidence for a previously undetected 11.2 micron UIR emission feature. Comparison with radio continuum maps indicates that the distribution of dust is similar to the distribution of ionized gas in each nebula. Various models of source morphology are also investigated. The planetary nebulae DB + 30 deg 3639 and NGC 6572 can be modeled by an optically thin cylinder or a prolate ellipsoid with enhanced equatorial emission. These models reproduce well the general features of the nebula, such as the bipolar lobes of emission and the ring structure. 67 refs

Petroleum and natural gas in the Federal Republic of Germany 2001; Erdoel und Erdgas in der Bundesrepublik Deutschland 2001

Energy Technology Data Exchange (ETDEWEB)

Pasternak, M.; Kosinowski, M.; Loesch, J.; Messner, J.; Sedlacek, R.

2002-07-01

After the last years had seen the lowest level of exploration activities, the year 2001 marked a distinct increase of exploration activities. This became quite visible in the number of completed exploration wells and in the extent of seismic surveys. Two of four new-field wildcats were completed in 2001, however without success. One of the three additional exploration wells (new-pool test and new-tectonic block) found gas. In production drilling nine of twelve wells were successful. Footage increased by near 25% compared to the preceding year and amounted to 54 030 metres. Seen in the light of history since 1945, this value marks the last but one rank compared to the last rank of the previous year. The rise of footage was achieved exclusively by exploration drilling. Footage of production drilling was slightly down. In geophysical prospecting the activities in 3D seismics reached the same level as in times of maximum seismic activities. The total area of 2400 square kilometres even exceeded the previous maximum. The main contribution was delivered by only one offshore survey in the German North Sea. 2D seismic was rather low and amounted to 450 kilometres in total. The license area for oil and gas exploration was reduced even further. As in previous years several expired licences were not extended and in some cases parts of the licence areas were relinquished. One licence around the city of Bremen was newly awarded. Two licences were awarded due to reorganisation of licence areas respectively due to adaptation to frontiers. In the state of Nordrhein-Westfalen three smaller licence areas were newly awarded aiming at producing gas from abandoned coal mines. German oil production could increase to 3.44 million metric tons due to the increase in production from the oil field Mittelplate to 1.6 million tons. In all other fields oil production decreased because of normal decline in production. Total remaining proven and probable oil reserves are reduced by 3 million tons to 46.8 million tons. Contrary to the trend of the last years the total remaining proven and probable natural gas reserves (raw gas) dropped by 34.4 billion cubic metres to 342.9 billion cubic metres due to production and the reassessment of existing fields. Reserve figures were 9% below the value of the preceding year. The gas production amounted to 21.5 billion cubic metres and equals the previous year value. The growth in underground gas storage continued. As in the preceding year 23 gas storage facilities in porous rocks and 19 gas storage facilities in salt caverns were in operation. The working gas volume increased by 0.5 billion cubic metres to 19.1 billion cubic metres. At present it is planned to raise the working gas volume by 4.4 billion cubic metres by building new storage facilities respectively by extension of existing facilities. (orig.)

Evaluation of the BD Vacutainer Plus Urine C&S Preservative Tubes compared with nonpreservative urine samples stored at 4°C and room temperature.

Science.gov (United States)

Eisinger, Stephen W; Schwartz, Matthew; Dam, Lisa; Riedel, Stefan

2013-09-01

The stability of urine specimens submitted for culture remains a challenge for many laboratories because of delays in specimen transport. We evaluated the usefulness of BD Vacutainer Plus Urine C&S Preservative Tube in ensuring specimen stability. Clinical urine specimens collected in sterile collection cups (n = 110) were plated onto sheep blood and MacConkey agar following standard laboratory procedures guidelines. Thereafter, specimens were divided into 3 storage conditions: nonpreservative, refrigerated; nonpreservative, room temperature (RT); BD Vacutainer Plus Urine C&S Preservative Tube, RT. For each sample type, additional cultures were set up at 2, 4, 24, and 48 hours. Initially, 18 specimens had no growth, 32 showed mixed skin flora, and 60 yielded at least 1 uropathogen. Increased colony counts of uropathogens were observed for nonpreserved urine samples stored at RT; these changes were statistically significant. Minor differences between refrigerated urine samples and BD Vacutainer Plus Urine C&S Preservative Tube samples were seen but were not statistically significant. The use of preservative-containing collection tubes is desirable to ensure specimen stability when prompt processing or refrigeration is not feasible.

Engagement für Flüchtlinge. Die Aufnahme vietnamesischer »Boat People« in der Bundesrepublik

Directory of Open Access Journals (Sweden)

Frank Bösch

2017-03-01

Full Text Available In the late 1970s, the Federal Republic of Germany witnessed a period of committed public outreach for Vietnamese refugees. While West Germany had not accepted significant numbers of non-European refugees before then, now tens of thousands of ›Boat People‹ rescued from the sea or flown out of camps found shelter as ›quota refugees‹. This article analyses the role civil society groups and political parties, media, and bureaucracy played in this. It shows that it was initially increasing public and international pressure that persuaded the social-liberal administration to accept refugees from Indochina, and that the concurrence of civic and state action subsequently reinforced the decision. Public pressure was created in large part by media campaigns and initiatives by Christian Democrats, who took a decisive stand in favour of taking in the refugees. A critical factor here was that the ›Boat People‹ were connected discursively with German post-war history. The article shows how refugee admission methods and new forms of humanitarian aid developed, both of which can be interpreted as civic and bureaucratic change. Rising xenophobia in the early 1980s eventually curbed this support. * * * In der Bundesrepublik entfaltete sich Ende der 1970er-Jahre eine engagierte Hilfe für Flüchtlinge aus Vietnam. Während Westdeutschland bis dahin kaum außereuropäische Flüchtlinge aufgenommen hatte, fanden nun mehrere zehntausend »Boat People« Schutz als »Kontingentflüchtlinge«, die im Meer gerettet und aus Lagern eingeflogen wurden. Der Aufsatz analysiert, welche Rolle dabei zivilgesellschaftliche Gruppen, politische Parteien, Medien und Bürokratie spielten. Anfangs bewegte vor allem öffentlicher und internationaler Druck die sozialliberale Regierung zur Aufnahme der Indochina-Flüchtlinge; später ergänzten sich zivilgesellschaftliches und staatliches Handeln aber wechselseitig. Der öffentliche Druck entstand insbesondere durch mediale

SPECIFIC MOOD SYMPTOMS CONFER RISK FOR SUBSEQUENT SUICIDAL IDEATION IN BIPOLAR DISORDER WITH AND WITHOUT SUICIDE ATTEMPT HISTORY: MULTI-WAVE DATA FROM STEP-BD.

Science.gov (United States)

Stange, Jonathan P; Kleiman, Evan M; Sylvia, Louisa G; Magalhães, Pedro Vieira da Silva; Berk, Michael; Nierenberg, Andrew A; Deckersbach, Thilo

2016-06-01

Little is known about specific mood symptoms that may confer risk for suicidal ideation (SI) among patients with bipolar disorder (BD). We evaluated prospectively whether particular symptoms of depression and mania precede the onset or worsening of SI, among adults with or without a history of a suicide attempt. We examined prospective data from a large (N = 2,741) cohort of patients participating in the Systematic Treatment Enhancement Program for BD (STEP-BD). We evaluated history of suicide attempts at baseline, and symptoms of depression and mania at baseline and follow-up visits. Hierarchical linear modeling tested whether specific mood symptoms predicted subsequent levels of SI, and whether the strength of the associations differed based on suicide attempt history, after accounting for the influence of other mood symptoms and current SI. Beyond overall current depression and mania symptom severity, baseline SI, and illness characteristics, several mood symptoms, including guilt, reduced self-esteem, psychomotor retardation and agitation, increases in appetite, and distractibility predicted more severe levels of subsequent SI. Problems with concentration, distraction, sleep loss and decreased need for sleep predicted subsequent SI more strongly among individuals with a suicide attempt history. Several specific mood symptoms may confer risk for the onset or worsening of SI among treatment-seeking patients with BD. Individuals with a previous suicide attempt may be at greater risk in part due to greater reactivity to certain mood symptoms in the form of SI. However, overall, effect sizes were small, suggesting the need to identify additional proximal predictors of SI. © 2016 Wiley Periodicals, Inc.

Structure of energy supply, energy analysis, projections for energy demand development and for emission-reducing energy carrier application in powered vehicles in the district Schmalkalden-Meiningen; Struktur der Energieversorgung, Energieanalysen, Prognosen zur Energiebedarfsentwicklung und zum emissionsmindernden Energietraegereinsatz fuer Kraftfahrzeuge im Landkreis Schmalkalden-Meiningen

Energy Technology Data Exchange (ETDEWEB)

Krah, N. [Fachhochschule Schmalkalden (Germany). Fachbereich Maschinenbau

2001-07-01

The present publication is based on facts, data, knowledge and projects, which have been incorporated in the development of an energy concept for the district Schmalkalden-Meiningen. The energy concept of a district is a concept oriented at action on and realisation of mid-term and long term decisions in the fields of energy policy, economy and ecology, which must be taken by municipal and economic decision-making bodies. The energy concept accords with the targets of the Agenda 21, the environmental targets of the Federal Republic of Germany and of the Land Thuringia. Accepting this energy concept the district Schmalkalden-Meiningen shows its willingness to contribute to a lasting development in all fields of economy and ecology and thus does justice to its increasing responsibility. (orig.) [German] Die vorliegende Veroeffentlichung baut auf Fakten, Daten, Erkenntnissen und Projekten auf, die in die Erarbeitung des Energiekonzeptes fuer den Landkreis Schmalkalden-Meiningen eingeflossen sind. Das Energiekonzept eines Landkreises ist ein handlungs- und umsetzungsorientiertes Konzept fuer mittel- und langfristige energiepolitische, wirtschaftliche und oekologische Entscheidungen, die kommunale und wirtschaftliche Entscheidungstraeger zu treffen haben. Es steht im Einklang mit den Zielen der Agenda 21, den Umweltzielen der Bundesrepublik Deutschland und denen des Landes Thueringen. Der Landkreis Schmalkalden-Meiningen hat mit der Annahme dieses Energiekonzeptes seine Bereitschaft dokumentiert, zu einer nachhaltigen Entwicklung in allen oekonomischen und oekologischen Bereichen beizutragen und seiner daraus erwachsenen Verantwortung gerecht zu werden. (orig.)

Editorial. Impact of the Binge Drinking (BD) in Adolescence. Are we doing it right? Editorial. Impacto del consumo episódico excesivo de alcohol en la adolescencia. ¿Lo estamos haciendo bien?

Science.gov (United States)

Vargas-Martínez, Ana Magdalena; Trapero-Bertran, Marta; Gil-García, Eugenia; Lima-Serrano, Marta

2018-04-15

Nowadays, one of the most prevalent patterns of alcohol consumption is called binge drinking (BD). In 2015, the European School Survey Project on Alcohol and Drugs (ESPAD) Group estimated that about 35% of adolescents of 15-16 years old have had at least one BD occasion in the past 30 days while at national level, the series of surveys on the use of drugs in adolescents of secondary education (ESTUDES, 2014-2015) determined that 32.2% of adolescents stated having performed BD in the last month. The aim of this editorial was to update the context of adolescence drinking and analysing the impact of BD by ages, including health and social costs derived. Once the magnitude of the problem was set, some research and action lines have been established in order to guide future work for the prevention of alcohol misuse and for establishing future preventive policies on alcohol. Finally, the need for evaluating these interventions from the efficiency point of view was discussed and assessed.

Ultraviolet observations of planetary nebulae NGC 6572, NGC 5315 and BD + 30/sup 0/ 3639

Energy Technology Data Exchange (ETDEWEB)

Torres-Peimbert, S; Pena, M [Universidad Nacional Autonoma de Mexico, Mexico City. Inst. de Astronomia

1981-01-01

We present IUE observations of three planetary nebulae. We have obtained the chemical composition of NGC 6572 to be log C = -3.60, log N = -3.67, log O = -3.27, and log Ne = -3.8. For NGC 5315 and BD + 30/sup 0/ 3639, the stellar WR contribution in the UV is very significant, and for these nebulae we are only able to derive the carbon abundance. We found log C = -3.01 and >-3.27, respectively.

PLANETS AROUND THE K-GIANTS BD+20 274 AND HD 219415

International Nuclear Information System (INIS)

Gettel, S.; Wolszczan, A.; Niedzielski, A.; Nowak, G.; Adamów, M.; Zieliński, P.; Maciejewski, G.

2012-01-01

We present the discovery of planet-mass companions to two giant stars by the ongoing Penn State-Toruń Planet Search conducted with the 9.2 m Hobby-Eberly Telescope. The less massive of these stars, K5-giant BD+20 274, has a 4.2 M J minimum mass planet orbiting the star at a 578 day period and a more distant, likely stellar-mass companion. The best currently available model of the planet orbiting the K0-giant HD 219415 points to a ∼> Jupiter-mass companion in a 5.7 year, eccentric orbit around the star, making it the longest period planet yet detected by our survey. This planet has an amplitude of ∼18 m s –1 , comparable to the median radial velocity 'jitter', typical of giant stars.

Development of a Real-Time PCR Protocol Requiring Minimal Handling for Detection of Vancomycin-Resistant Enterococci with the Fully Automated BD Max System.

Science.gov (United States)

Dalpke, Alexander H; Hofko, Marjeta; Zimmermann, Stefan

2016-09-01

Vancomycin-resistant enterococci (VRE) are an important cause of health care-associated infections, resulting in significant mortality and a significant economic burden in hospitals. Active surveillance for at-risk populations contributes to the prevention of infections with VRE. The availability of a combination of automation and molecular detection procedures for rapid screening would be beneficial. Here, we report on the development of a laboratory-developed PCR for detection of VRE which runs on the fully automated Becton Dickinson (BD) Max platform, which combines DNA extraction, PCR setup, and real-time PCR amplification. We evaluated two protocols: one using a liquid master mix and the other employing commercially ordered dry-down reagents. The BD Max VRE PCR was evaluated in two rounds with 86 and 61 rectal elution swab (eSwab) samples, and the results were compared to the culture results. The sensitivities of the different PCR formats were 84 to 100% for vanA and 83.7 to 100% for vanB; specificities were 96.8 to 100% for vanA and 81.8 to 97% for vanB The use of dry-down reagents and the ExK DNA-2 kit for extraction showed that the samples were less inhibited (3.3%) than they were by the use of the liquid master mix (14.8%). Adoption of a cutoff threshold cycle of 35 for discrimination of vanB-positive samples allowed an increase of specificity to 87.9%. The performance of the BD Max VRE assay equaled that of the BD GeneOhm VanR assay, which was run in parallel. The use of dry-down reagents simplifies the assay and omits any need to handle liquid PCR reagents. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Potential applications of medium-sized, superconducting magnetic energy storage devices (SMES) in Germany; Einsatzmoeglichkeiten fuer mittelgrosse supraleitende magnetische Energiespeicher (SMES) in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Prescher, K; Nick, W; Vollmar, H E; Kleinmaier, M; Radtke, U

1995-05-01

The paper addresses economic aspects of applying SMES instead of conventional methods in the electricity supply sector in Germany. Compared to the process of throttling of turbine valves hitherto used in steam power plants, the use of SMES will bring about advantages such as fuel savings, reduced emission, and improved utilisation of the existing power plant park in Germany. The paper presents a feasibility and cost study of a specified application of SMES. (orig.) [Deutsch] Praesentiert werden wirtschaftliche Beurteilungen, supraleitende Energiespeicher statt konventioneller Methoden in der elektrischen Energieversorgung in Deutschland einzusetzen. Anstelle der heute vorherrschenden Androsselung der Turbinenventile in Dampfkraftwerken sind bei Ersatz durch SMES Brennstoffeinsparungen, Emissionsminderungen und eine hoehere Ausnutzung des bestehenden Kraftwerksparks zu erwarten. Ein konkreter Anwendungsfall wird bezueglich technischer Machbarkeit und Kosten detaillierter untersucht. (orig.)

X-RAY OBSERVATIONS OF BOW SHOCKS AROUND RUNAWAY O STARS. THE CASE OF ζ OPH AND BD+43°3654

Energy Technology Data Exchange (ETDEWEB)

Toalá, J. A.; Guerrero, M. A. [Instituto de Astrofísica de Andalucía, IAA-CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Oskinova, L. M.; González-Galán, A. [Institute for Physics and Astronomy, University of Potsdam, D-14476 Potsdam (Germany); Ignace, R. [Department of Physics and Astronomy, East Tennessee State University, Johnson City, TN 37614 (United States); Pohl, M., E-mail: toala@iaa.es [Institute of Astronomy and Astrophysics, Academia Sinica (ASIAA), Taipei 10617,Taiwan (China)

2016-04-20

Non-thermal radiation has been predicted within bow shocks around runaway stars by recent theoretical works. We present X-ray observations toward the runaway stars ζ Oph by Chandra and Suzaku and of BD+43°3654 by XMM-Newton to search for the presence of non-thermal X-ray emission. We found no evidence of non-thermal emission spatially coincident with the bow shocks; nonetheless, diffuse emission was detected in the vicinity of ζ Oph. After a careful analysis of its spectral characteristics, we conclude that this emission has a thermal nature with a plasma temperature of T ≈ 2 × 10{sup 6} K. The cometary shape of this emission seems to be in line with recent predictions of radiation-hydrodynamic models of runaway stars. The case of BD+43°3654 is puzzling, as non-thermal emission has been reported in a previous work for this source.

13 CFR 124.503 - How does SBA accept a procurement for award through the 8(a) BD program?

Science.gov (United States)

2010-01-01

... under the 8(a) BD program. (g) Basic Ordering Agreements (BOAs). A Basic Ordering Agreement (BOA) is not a contract under the FAR. See 48 CFR 16.703(a). Each order to be issued under the BOA is an... BOA in addition to offering and accepting the BOA itself. (1) SBA will not accept for award on a sole...

Purification and characterization of a novel milk-clotting metalloproteinase from Paenibacillus spp. BD3526.

Science.gov (United States)

Hang, Feng; Wang, Qinbo; Hong, Qing; Liu, Peiyi; Wu, Zhengjun; Liu, Zhenmin; Zhang, Hao; Chen, Wei

2016-04-01

In this study, a milk-clotting enzyme (MCE) isolated from Paenibacillus spp. BD3526 was purified and characterized. The MCE was purified 8.9-fold with a 10.11% recovery using ammonium sulfate precipitation and anion-exchange chromatography and the specific milk-clotting activity (MCA) reached 6791.73 SU/mg. The enzyme was characterized as a 35kDa metalloproteinase, and the zymogen of which was encoded by a 1671 bp gene named zinc metalloproteinase precursor (zmp) with a predicted molecular weight of 59.6 kDa. The optimal temperature for MCA and proteolytic activity (PA) was 65°C and 60°C, respectively. The enzyme was stable over a pH range of 5.0-9.0 and at temperatures below 50°C. The MCA was completely inactivated when the enzyme was heated at 60°C for 30 min, and the PA was totally inactivated for 20 and 10 min when the enzyme was heated at 55°C and 60°C, respectively. The BD3526 enzyme was preferentially active towards κ-casein (κ-CN) and β-casein (β-CN), as determined by sodium dodecyl sulfate-polyacrylamide gels (SDS-PAGE), whereas the hydrolysis of αs-casein (αs-CN) was slow and comparable to that caused by chymosin and asparatic acid proteinase from Rhizomucor miehei. The cleavage site of the metalloproteinase in κ-CN was located at the Met106-Ala107 bond, as determined by mass spectrometry analysis. Copyright © 2016. Published by Elsevier B.V.

Tracking Advanced Planetary Systems (TAPAS) with HARPS-N. V. A Massive Jupiter orbiting the very-low-metallicity giant star BD+03 2562 and a possible planet around HD 103485

Science.gov (United States)

Villaver, E.; Niedzielski, A.; Wolszczan, A.; Nowak, G.; Kowalik, K.; Adamów, M.; Maciejewski, G.; Deka-Szymankiewicz, B.; Maldonado, J.

2017-10-01

Context. Evolved stars with planets are crucial to understanding the dependency of the planet formation mechanism on the mass and metallicity of the parent star and to studying star-planet interactions. Aims: We present two evolved stars (HD 103485 and BD+03 2562) from the Tracking Advanced PlAnetary Systems (TAPAS) with HARPS-N project devoted to RV precision measurements of identified candidates within the PennState - Toruń Centre for Astronomy Planet Search. Methods: The paper is based on precise radial velocity (RV) measurements. For HD 103485 we collected 57 epochs over 3317 days with the Hobby-Eberly Telescope (HET) and its high-resolution spectrograph and 18 ultra-precise HARPS-N data over 919 days. For BD+03 2562 we collected 46 epochs of HET data over 3380 days and 19 epochs of HARPS-N data over 919 days. Results: We present the analysis of the data and the search for correlations between the RV signal and stellar activity, stellar rotation, and photometric variability. Based on the available data, we interpret the RV variations measured in both stars as Keplerian motion. Both stars have masses close to Solar (1.11 M⊙ HD 103485 and 1.14 M⊙ BD+03 2562), very low metallicities ([Fe/H] = - 0.50 and - 0.71 for HD 103485 and BD+03 2562), and both have Jupiter planetary mass companions (m2sini = 7 and 6.4 MJ for HD 103485 and BD+03 2562 resp.) in close to terrestrial orbits (1.4 au HD 103485 and 1.3 au BD+03 2562) with moderate eccentricities (e = 0.34 and 0.2 for HD 103485 and BD+03 2562). However, we cannot totally rule-out the possibility that the signal in the case of HD 103485 is due to rotational modulation of active regions. Conclusions: Based on the current data, we conclude that BD+03 2562 has a bona fide planetary companion while for HD 103485 we cannot totally exclude the possibility that the best explanation for the RV signal modulations is not the existence of a planet but stellar activity. If the interpretation remains that both stars have

Sewage sludge volumes and disposal strategies in Germany and Europe today; Aktuelle Klaerschlammmengen und Ihre Entsorgung in Deutschland und Europa

Energy Technology Data Exchange (ETDEWEB)

Esch, B.; Loll, U.

2001-07-01

This report presents the latest data published by the Federal Statistical Authority on the quantities of sewage sludges in Germany and their disposal. It also shows the quantities and their relation to the population. In addition to the quantities of sewage sludge, their qualities are also shown. The report is completed by data from the European Union. With brief explanations and clear graphics, the statistical key data can help anybody to achieve an extensive overview of the subject. The report also gives ideas for in-debth studies. [German] In vorliegendem Bericht werden die aktuellsten Daten des Statistischen Bundesamtes zum Anfall und Entsorgung der Klaerschlaemme in Deutschland vorgestellt. Es wird weiterhin dargestellt, wie sich die Mengen im Verhaeltnis zwischen Einwohner und Einwohnergleichwerten verhalten. Neben den Klaerschlammmengen werden auch die Klaerschlammqualitaeten dargestellt. Ergaenzt wird dieser Bericht durch Daten aus der Europaeischen Union. Mit kurzen Erlaeuterungen und anschaulichen Grafiken koennen die Eckdaten der Statistik jedem zu einem umfassenden Ueberblick verhelfen. Fuer vertiefende Studien werden Anhaltspunkte und Anregungen gegeben. (orig.)

Renewable energies in Germany. Data on the development in 2016; Erneuerbare Energien in Deutschland. Daten zur Entwicklung im Jahr 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-03-15

The Working Group on Renewable Energy Statistics (AGEE-Stat), which regularly evaluates the use of renewable energies on behalf of the German Federal Ministry of Economics and Energy, has made an initial assessment of the development of renewable energies in Germany on the basis of available, mostly provisional data of 2016. The present background paper describes the previous findings for the areas of electricity, heat and transport, supplemented by figures on economic significance as well as on emission reductions through renewable energies. [German] Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des Bundesministeriums fuer Wirtschaft und Energie regelmaessig die Nutzung der erneuerbaren Energien bilanziert, hat auf der Grundlage verfuegbarer, zumeist vorlaeufiger Daten eine erste Abschaetzung zur Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2016 erstellt. Das vorliegende Hintergrundpapier beschreibt die bisherigen Erkenntnisse fuer die Bereiche Strom, Waerme und Verkehr, ergaenzt um Zahlen zur wirtschaftlichen Bedeutung sowie zur Emissionsvermeidung durch erneuerbare Energien.

Natural genetic transformation in Acinetobacter sp. BD413 Biofilms: introducing natural genetic transformation as a tool for bioenhancement of biofilm reactors

Energy Technology Data Exchange (ETDEWEB)

Hendrickx, L

2002-07-01

This study focussed on the localization and quantification of natural genetic transformation using neutral and disadvantageous genes in monoculture biofilms to investigate gene transfer and expression of the transferred genes in the absence of a selective advantage. Data obtained by this investigation were regarded as initial steps for evaluating the applicability of adding catabolic traits into the indigenous bacterial community of biofilm reactors by in situ natural genetic transformation. Because Acinetobacter spp. strains are readily found in waste water treatment plants and because Acinetobacter sp. BD413 possesses a high effective level of competence, natural genetic transformation was investigated in monoculture Acinetobacter sp. BD413 biofilms. The genes used for transformation encoded for the green fluorescent protein (GFP) and its variants. Monitoring of transformation events were performed with the use of automated confocal laser scanning microscopy (CLSM) and semi automated digital image processing and analysis. (orig.)

Crude oil and natural gas in the Federal Republic of Germany 1997; Erdoel und Erdgas in der Bundesrepublik Deutschland 1997

Energy Technology Data Exchange (ETDEWEB)

Pasternak, M.; Kosinowski, M.; Loesch, J.; Meyer, H.J.; Porth, H.; Sedlacek, R.

1998-12-31

In 1997, exploration for oil and gas in onshore Germany further slowed down compared to the previous years. Both the number of exploration wells and the geophysical activity (seismic and gravimetric field surveys) decreased. In contrast, extensive seismic measurements were conducted in the German sector of the North Sea. Oil production amounted to 2.82x10{sup 6} t which is approximately the same level as in 1996. Due to the mild winter, gas production slightly decreased to 22.5x10{sup 9} m{sup 3} (raw gas). Underground gas storage in depleted oil or gas fields, in aquifer structures and salt caverns continued to play a very important role in Germany. The total working gas capacity of the 38 existing storage plants increased by 1.3x10{sup 9} m{sup 3} to 15.4x10{sup 9} m{sup 3}. An additional capacity of 7.1x10{sup 9} m{sup 3} is under construction or in the planning stage. (orig./MSK) [Deutsch] Im Jahre 1997 ist die Aufsuchungstaetigkeit nach Erdgas und Erdoel auf dem deutschen Festland gemessen an der Anzahl der Explorationsbohrungen und dem Umfang der geophysikalischen Feldmessungen (Seismik, Gravimetrie) dem Trend des Vorjahres folgend zurueckgegangen. Demgegenueber standen umfangreiche seismische Untersuchungen in der Nordsee. Die Erdoelfoerderung hat sich mit 2,82 Mio. t ungefaehr auf dem Niveau des Vorjahres gehalten. Die Erdgasfoerderung hat gegenueber 1996 witterungsbedingt geringfuegig abgenommen und betrug 22,5 Mrd. m{sup 3}(V{sub n})/a (natuerlicher Brennwert). Auf dem Sektor der Untertage-Erdgasspeicher (ehem. Lagerstaetten, Aquifere und Salzkavernen) setzte sich auch im Jahre 1997 der Wachstumstrend fort. Gegenueber dem Vorjahr stieg das Arbeitsgasvolumen in 23 Porenspeicher- und 15 Kavernenspeicher-Betrieben um etwa 1,3 Mrd. m{sup 3}(V{sub n}) auf 15,4 Mrd. m{sup 3}(V{sub n}) an. Weitere ca. 7,1 Mrd. m{sup 3}(V{sub n}) Arbeitsgas sind in neuen Projekten oder durch Erweiterung bestehender Projekte in Planung und Bau. (orig./MSK)

The effectiveness of BD Vacutainer® Plus Urinalysis Preservative Tubes in preservation of urine for chemical strip analysis and particle counting.

Science.gov (United States)

Ekşioğlu, Merve Kaymak; Madenci, Özlem Çakır; Yücel, Nihal; Elçi, Abdullah; Turhan, Bülent; Orhan, Gani; Orçun, Asuman

2016-01-01

The aim of this study was to evaluate the stability of urine collected in preservative tubes for chemistry strip analyses and particle counting to determine whether the transport of urine samples with all of their constituents is possible. 275 pathologic urine specimens were included. Each urine sample was evaluated after 4, 8, 12, 24, and 48 hours of storage in BD Vacutainer(®) Plus Urinalysis Preservative (BD UAP) tubes and compared with refrigeration at 4 °C. All analyses were peformed on H-800 and FUS-200 automatic modular urine analyzers (Dirui Industry, Changchun, China). The kappa coefficients (κ), false positive (FP) and false negative (FN) rates were evaluated. κ > 0.8 was accepted as good agreement. Haemoglobin (Hb), leucocyte esterase (LE), and protein (Pro) analyses should be performed within 4 hours, whereas glucose (Glc) was stable until the end of 48 hours in both storage conditions. Nitrite (Nit) was well preserved in BD UAP tubes for 24 hours but was stable only up to 8 hours at 4 °C. Bilirubin (Bil) had very high FN rates even at 4 hours in both conditions. The particle counting showed high FN rates for white blood cells (WBC) and red blood cells (RBC), whereas squamous epithelial cells (EC) were stable up to 8 hours in both conditions. Preanalytical requirements for both urine chemical strip analyses and particle counting in a unique sample were not met in either condition. Thus, the transfer of urine samples for centralization of urinalysis is not yet feasible.

The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines.

Science.gov (United States)

Burgey, Christine; Kern, Winfried V; Römer, Winfried; Sakinc, Türkan; Rieg, Siegbert

2015-05-01

Antimicrobial peptides are multifunctional effector molecules of innate immunity. In this study we investigated whether endothelial cells actively contribute to innate defense mechanisms by expression of antimicrobial peptides. We therefore stimulated human umbilical vein endothelial cells (HUVEC) with inflammatory cytokines, Th17 cytokines, heat-inactivated bacteria, bacterial conditioned medium (BCM) of Staphylococcus aureus and Streptococcus sanguinis, and lipoteichoic acid (LTA). Stimulation with single cytokines induced discrete expression of human β-defensin 3 (hBD3) by IFN-γ or IL-1β and of ribonuclease 7 (RNase7) by TNF-α without any effects on LL-37 gene expression. Stronger hBD3 and RNase7 induction was observed after combined stimulation with IL-1β, TNF-α and IFN-γ and was confirmed by high hBD3 and RNase7 peptide levels in cell culture supernatants. In contrast, Th17 cytokines or stimulation with LTA did not result in AMP production. Moreover, only BCM of an invasive S. aureus bacteremia isolate induced hBD3 in HUVEC. We conclude that endothelial cells actively contribute to prevent dissemination of pathogens at the blood-tissue-barrier by production of AMPs that exhibit microbicidal and immunomodulatory functions. Further investigations should focus on tissue-specific AMP induction in different endothelial cell types, on pathogen-specific induction patterns and potentially involved pattern-recognition receptors of endothelial cells. Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

Particle Reduction Strategies - PAREST. Prognosis of air quality and assessment of limit value exceedances in Germany for the reference years 2010, 2015 and 2020; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Prognose der Luftqualitaet und Abschaetzung von Grenzwertueberschreitungen in Deutschland fuer die Referenzjahre 2010, 2015 und 2020. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

2013-06-15

With the help of a data assimilation technique (optimal interpolation) a comprehensive forecast of O{sub 3}, PM10 and NO{sub 2} air quality in Germany for the years 2010, 2015 and 2020 was prepared. Based on these results, an assessment was made whether the limits of the European Air Quality Directive (2008/50/EC) can be observed in 2015 and 2020. [German] In diesem Bericht wurde mit Hilfe einer Datenassimilationstechnik (Optimale Interpolation) eine flaechendeckende Prognose der O{sub 3}-, PM10- und NO{sub 2}-Luftqualitaet in Deutschland fuer die Jahre 2010, 2015 und 2020 erstellt. Auf Basis dieser Ergebnisse wurde eine Abschaetzung vorgenommen, ob die Grenzwerte der europaeischen Luftqualitaetsrichtlinie (2008/50/EG) im Jahre 2015 und 2020 eingehalten werden koennen. Weiterhin wurde untersucht, was die in der Luftqualitaetsrichtlinie festgelegten Regelungen fuer die Feinstaeube PM2.5 fuer die PM2.5-Belastung in Deutschland bedeuten und ob das nationale Ziel fuer die Reduktion der PM2.5-Belastung unter den Emissionsbedingungen des Jahres 2020 erreicht werden kann.

"Was bedeutet ein Wal für Sie?" – Divergenzen von Walperzeptionen in Deutschland, Japan und Grönland

Directory of Open Access Journals (Sweden)

Frank Sowa

2013-01-01

Full Text Available In sozial- und kulturwissenschaftlichen Studien der 1990er Jahren fanden unterschiedliche Wahrnehmungen von Natur ihren Ausdruck in den Kategorien "Nation" und "Kultur". Auch in wissenschaftlichen und öffentlichen Diskursen zum Thema Walfang werden häufig unterschiedliche Einstellungen in kulturellen oder nationalen Kategorien ausgedrückt. Daraus resultieren Essentialisierungen, die sich begrifflich als Antiwalfangnationen vs. Walfangnationen oder fleischbasierte vs. fischbasierte Ernährungsweise fassen lassen. Der Konflikt um die Fortführung des internationalen Walfanges generiert auf diese Weise dichotomische Esskulturen. Doch unklar bleibt, welche Bedeutung eigentlich Wale für Menschen haben. Im Rahmen eines Feldforschungsprojektes wurden Menschen in Deutschland, Grönland und Japan die Abschlussfrage "Was bedeutet ein Wal für Sie?" gestellt. Es zeigt sich, dass die Antworten die dominante Perzeption von Walen, wie sie sich für euro-amerikanische Gesellschaften rekonstruieren lässt, infrage stellen und die Unterschiedlichkeit der Narrationen sich nicht entlang von kulturellen oder nationalen Grenzen begründen lässt. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1301100

Experimental investigations concerning the three particle reaction 19B(d,3α) at 360 keV

International Nuclear Information System (INIS)

Nocken, U.

1976-01-01

In this paper a complete energy angular correlation measurement of the three-particle reaction 10 B(d,3α) with an incident energy of Esub(d) = 360 keV is reported. By the measurement of coincidence events in two detectors complanar to the incident beam under 24 different angles, the 'Dalitz-plane' is covered in a wide region. An exact theory of three-particle reactions with compound nuclei in the final state does not exist, therefore three wellknown model theories are used for comparison. (orig./WL) [de

Germany's first CO{sub 2} skating rink. Axima Kaeltetechnik builds new skating rink at Ravensburg; Die erste CO{sub 2}-Kunsteisbahn Deutschlands. Axima Kaeltetechnik baut in Ravensburg

Energy Technology Data Exchange (ETDEWEB)

Anon.

2004-04-01

Natural refrigerants are frequently used in skating rinks. Increasingly, CO2 is preferred to brine, as in the new Ravensburg skating rink. It is the first time this technology is applied in Germany, but more systems of this kind are sure to come. [German] Beim Bau von Kunsteisbahnen sind natuerliche Kaeltemittel kein Novum. Immer haeufiger erhaelt allerdings der Kaeltetraeger CO{sub 2} den Vorzug vor einer Sole, so auch beim Bau der neuen Kunsteisbahn in Ravensburg. Damit wurde erstmals in Deutschland in diesem Bereich der Schritt hin zu einer Systemtechnologie gemacht, die aller Voraussicht nach noch zahlreiche weitere Anwendungen nach sich ziehen wird. (orig.)

Suzaku Reveals Helium-burning Products in the X-Ray-emitting Planetary Nebula BD +30 3639

Science.gov (United States)

Murashima, M.; Kokubun, M.; Makishima, K.; Kotoku, J.; Murakami, H.; Matsushita, K.; Hayashida, K.; Arnaud, K.; Hamaguchi, K.; Matsumoto, H.

2006-08-01

BD +30 3639, the brightest planetary nebula at X-ray energies, was observed with Suzaku, an X-ray observatory launched on 2005 July 10. Using the X-ray Imaging Spectrometer, the K lines from C VI, O VII, and O VIII were resolved for the first time, and the C/O, N/O, and Ne/O abundance ratios were determined. The C/O and Ne/O abundance ratios exceed the solar value by factors of at least 30 and 5, respectively. These results indicate that the X-rays are emitted mainly by helium-shell-burning products.

Isolation and characterization of two new lipopeptide biosurfactants produced by Pseudomonas fluorescens BD5 isolated from water from the Arctic Archipelago of Svalbard

Czech Academy of Sciences Publication Activity Database

Janek, T.; Lukaszewicz, M.; Řezanka, Tomáš; Krasowska, A.

2010-01-01

Roč. 101, č. 15 (2010), s. 6118-6123 ISSN 0960-8524 Institutional research plan: CEZ:AV0Z50200510 Keywords : Pseudomonas fluorescens BD5 * Lipopeptide * Pseudofactins Subject RIV: EE - Microbiology, Virology Impact factor: 4.365, year: 2010

Raw materials and energy - effects of globalization on the safety of German's supply sufficiency; Rohstoffe und Energie. Auswirkungen der Globalisierung auf die Versorgungssicherheit Deutschlands

Energy Technology Data Exchange (ETDEWEB)

Wellmer, F.W. [Technische Univ. Berlin (Germany)

2001-07-01

Raw material deposits are not mobile, so globalisation has always been an important element of raw materials production and trade. Raw materials production and transport should be regarded as a large-scale system. Lower freight rates have made overseas transport possible even for bulk raw materials. If we look at Germany's raw materials supply, we find that we are customers buying from the whole world. [German] Da Lagerstaetten ortsgebunden sind, ist Globalisierung seit jeher ein wesentliches Element von Rohstoffgewinnung und handel. Rohstoffgewinnung und Transportmoeglichkeiten muessen als Grosssystem betrachtet werden. Nicht zuletzt wegen der gesunkenen Frachtraten ist der ueberseeische Transport heute selbst fuer Massenrohstoffe moeglich geworden. Betrachtet man die Rohstoffversorgung Deutschlands, wird deutlich, dass wir Kunde der ganzen Welt sind. (orig.)

Final storage of radioactive waste in Germany. Waste arisings and availability of a repository as seen by an electricity utility; Endlagerung radioaktiver Abfaelle in Deutschland. Abfallaufkommen und Endlagerverfuegbarkeit aus EVU-Sicht

Energy Technology Data Exchange (ETDEWEB)

Broeskamp, H.; Brammer, K.J.; Graf, R. [Gesellschaft fuer Nuklearservice, Essen (Germany)

2004-04-01

friedlichen Nutzung der Kernenergie in Deutschland an beruecksichtigt. Bereits 1957 wird in einem Memorandum der Deutschen Atomkommission der Hinweis auf die Notwendigkeit der sicheren Beseitigung der radioaktiven Abfaelle formuliert. Der Gesetzgeber hat diese Anregung aufgegriffen und schon im Atomgesetz vom 23.12.1959 Vorschriften zur schadlosen Verwertung radioaktiver Stoffe angelegt. Von der Bundesrepublik wurde in Zusammenhang mit dem Nuklearen Entsorgungszentrum auch nach einem geeigneten Endlagerstandort gesucht. Nach einer intensiven Standortsuche durch die Bundesregierung und das Land Niedersachsen benannte die Niedersaechsische Landesregierung 1977 Gorleben als Standort. Vorausgegangen war ein 3-stufiges Auswahlverfahren, in dem mehr als 140 Standorte betrachtet wurden. Die Arbeiten zur Erkundung des Standortes Gorleben begannen 1979 und wurden am 01.10.2000 zur Klaerung von konzeptionellen und sicherheitstechnischen Zweifeln der Bundesregierung unterbrochen. Vom BMU wird die Verfuegbarkeit eines (Hochaktiv-)Endlagers im Jahr 2030 angestrebt. Aus technischer Sicht ist eine Inbetriebnahme eines Endlagers fuer waermeentwickelnde Abfaelle in Gorleben ab dem Jahr 2025 noch erreichbar, sofern sich der Salzstock nach zuegigem Abschluss der Erkundungsarbeiten als geeignet erweist. Auf die absehbaren Problemfelder wird hingewiesen. Ein weiteres Projekt der Bundesregierung ist die Nutzung der Schachtanlage Konrad als Endlager fuer schwach- und mittelradioaktive Abfaelle. Der Planfeststellungsbeschluss wurde nach gut 20 Jahren im Mai 2002 erteilt und ist zurzeit noch beklagt. Aus den dargestellten Angaben zum erwarteten Abfallvolumen der nicht-waermeentwickelnden EVU-Abfaelle in Verbindung mit dem moeglichen Beginn des Einlagerungsbetriebs Konrad 2013 werden detaillierte Ergebnisse vorgestellt. (orig.)

Legal instruments for groundwater protection. A systematic analysis of EU law and German federal law and state law; Rechtliche Instrumente des Grundwasserschutzes. Eine systematische Analyse des EG-, Bundes- und Landesrechts

Energy Technology Data Exchange (ETDEWEB)

Kotulla, M.

1999-07-01

In Germany, the groundwater quality is endangered by a great variety of anthropogenic activities. Although it is widely accepted that the situation calls for quick action and implementation of legal provisions for efficient, nationwide protection of this essential natural resource, the legislature so far remained disappointingly inactive. This is why the author of the study presented in this book examines existing German federal and state law as well as EU law in order to reveal the possibilities offered by those bodies of law. The author analyses the many, splintered legal provisions under public law that are applicable today in Germany in absence of a proper code of environmental law, for their capability of being applied for protection of the groundwater. The legal instruments are identified and evaluated for the given purpose, and approaches for harmonisation or maybe optimisation are elaborated. (orig./CB) [German] Das Grundwasser in der Bundesrepublik Deutschland ist von einer Vielzahl zivilisatorischer Aktivitaeten bedroht. Strategien fuer einen prinzipiell flaechendeckend wirksamen Schutz dieser Naturressource werden zwar mittlerweile allenthalben gefordert, zeigen bislang aber nicht die erhoffte Wirkung. Vor diesem Hintergrund untersucht der Autor in dieser Studie die rechtlichen Moeglichkeiten, welche die bundesdeutsche Rechtsordnung unter Einbeziehung des einschlaegigen EG-Rechts zum Schutz des Grundwassers bereithaelt. Er analysiert primaer das in den letzten dreieinhalb Jahrzehnten zu einem unueberschaubaren Konglomerat angewachsene oeffentlich-rechtliche Umweltschutzregelwerk auf seine grundwasserschuetzende Eignung. Es gilt insbesondere, die diffus und querschnittartig ueber die verschiedensten Rechtsbereiche vertreuten Instrumentarien zu ermitteln und zu bewerten sowie - wo erforderlich - zu harmonisieren oder gar zu optimieren. (orig.)

Bd on the beach: high prevalence of Batrachochytrium dendrobatidis in the lowland forests of Gorgona Island (Colombia, South America).

Science.gov (United States)

Flechas, Sandra Victoria; Sarmiento, Carolina; Amézquita, Adolfo

2012-09-01

The amphibian chytrid fungus, Batrachochytrium dendrobatidis, Bd, has been implicated in the decimation and extinction of many amphibian populations worldwide, especially at mid and high elevations. Recent studies have demonstrated the presence of the pathogen in the lowlands from Australia and Central America. We extend here its elevational range by demonstrating its presence at the sea level, in the lowland forests of Gorgona Island, off the Pacific coast of Colombia. We conducted two field surveys, separated by four years, and diagnosed Bd by performing polymerase chain reactions on swab samples from the skin of five amphibian species. All species, including the Critically Endangered Atelopus elegans, tested positive for the pathogen, with prevalences between 3.9 % in A. elegans (in 2010) and 52 % in Pristimantis achatinus. Clinical signs of chytridiomycosis were not detected in any species. To our knowledge, this is the first report of B. dendrobatidis in tropical lowlands at sea level, where temperatures may exceed optimal growth temperatures of this pathogen. This finding highlights the need to understand the mechanisms allowing the interaction between frogs and pathogen in lowland ecosystems.

Highly efficient decolorization of Malachite Green by a novel Micrococcus sp. strain BD15.

Science.gov (United States)

Du, Lin-Na; Zhao, Ming; Li, Gang; Zhao, Xiao-Ping; Zhao, Yu-Hua

2011-08-01

Malachite Green (MG) is used for a variety of applications but is also known to be carcinogenic and mutagenic. In this study, a novel Micrococcus sp. (strain BD15) was observed to efficiently decolorize MG. The purposes of this study were to explore the optimal conditions for decolorization and to evaluate the potential use of this strain for MG decolorization. Optical microscope and UV-visible analyses were carried out to determine whether the decolorization was due to biosorption or biodegradation. A Plackett-Burman design was employed to investigate the effect of various parameters on decolorization, and response surface methodology was then used to explore the optimal decolorization conditions. Kinetics analysis and antimicrobial activity tests were also performed. The results indicated that the decolorization by the strain was mainly due to biodegradation. Concentrations of MG, urea, and yeast extract and inoculum size had significantly positive effects on MG decolorization, while concentrations of CuCl(2) and MgCl(2), and temperature had significantly negative effects. The interaction between different parameters could significantly affect decolorization, and the optimal conditions for decolorization were 1.0 g/L urea, 0.9 g/L yeast extract, 100 mg/L MG, 0.1 g/L inoculums (dry weight), and incubation at 25.2°C. Under the optimal conditions, 96.9% of MG was removed by the strain within 1 h, which represents highly efficient microbial decolorization. Moreover, the kinetic data for decolorization fit a second-order model well, and the strain showed a good MG detoxification capability. Based on the results of this study, we propose Micrococcus sp. strain BD15 as an excellent candidate strain for MG removal from wastewater.

German Environmental Information Network - GEIN; Grundlagen der Umweltpolitik, Umweltstrategien. Umweltinformationsnetz Deutschland - GEIN

Energy Technology Data Exchange (ETDEWEB)

Bandholtz, T.

2001-05-01

The German Environmental Information Network (GEIN) consolidates a wide range of information currently distributed across many different Web sites run by public institutions in Germany, such as environmental authorities, agencies and ministries at the federal and Land (state) levels. The 'Portal to German Environmental Information' offers an easy-to-use access for any internet user by one single address, supporting the choice of search conditions through thesaurus-terms, geographic names, and an interactive environmental calendar. Behind that a unique XML namespace giving a solid semantic ground to bhe communication between the information providers and their 'broker'. GEIN supports automatic, thesaurus-based indexing, and a fast broadcasting mechanism (XML via HTTP) for queries that cannot be processed using the index only. Since GEIN has been inaugurated on June 9th, 2000, it has found a broad acceptance in the general public as well as with the professionals. (orig.) [German] Das Umweltinformationsnetz Deutschland (GEIN) vereint ein weites Spektrum an Umweltinformation von oeffentlichen Einrichtungen und Behoerden im Internet, die zuvor allein ueber zahlreiche individuelle Websites erreichbar war. Das 'Portal der Deutschen Umweltinformation' bietet jedem Internetbenutzer zu diesen Informationen einen umkomplizierten Zugang ueber eine einzige Adresse. Darueber hinaus erhaelt der Benutzer vielfaeltige Unterstuetzung bei der Wahl geeigneter Suchbedingungen durch Fach-Vokabular, geografische Namen und einen interaktiven Umweltkalender. Dahinter steht ein eigener XML-'Namensraum' (namespace), der die Kommunikation zwischen den einzelnen Informationsanbietern und ihrem gemeinsamen 'Broker' auf eine stabile semantische Grundlage stellt. GEIN verfuegt ueber ein thesaurus-basiertes Indizierungsverfahren, sowie ueber einen schnellen Verteilungs-mechanismus fuer Anfragen, die nicht aus dem Index beantwortet werden koennen

Trends and perspectives of raw materials supply in Germany in the 21st millennium. Colloquium 5. Conference report; Trends und Perspektiven der Rohstoffversorgung Deutschlands im 21. Jahrhundert. Kolloquium 5. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

Slaby, D; Brezinski, H [comps.; Technische Univ. Bergakademie Freiberg (Germany). Fakultaet fuer Wirtschaftswissenschaften; Gerhardt, H [comp.; Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Herzig, P [comp.; Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Mineralogie

1999-07-01

The conference report comprises papers on raw materials policy and management, coal mining in Poland and Czekhia, perspectives of raw materials supply in Germany, mining law and raw materials supply, information systems for regional planning, and the use of washery tailings as construction materials. Ten papers have been recorded separately in the ENERGY database. [German] Der Tagungsband enthaelt Beitraege, die neben der Energierohstoffpolitik, die Rohstoffwirtschaft, den Kohlenbergbau in Polen und Tschechien betreffen. Es werden Perpesktiven der Rohstoffversorgung Deutschlands in der Zukunft sowie Bergrecht und Rohstoffsicherung diskutiert. Weitere Arbeiten betreffen Informationssyteme zur Regionalplannung sowie die Verwertung von Waschbergen als Baustoffersatz. Fuer die Datenbank Energy wurden zehn Beitraege separat aufgenommen.

Survey of legislation applicable in Germany for implementation of the EC Directive on environmental audits; Ueberblick ueber die in Deutschland fuer die Ausfuehrung der EG-Umwelt-Audit-Verordnung geltenden Rechtsvorschriften

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

The brochure presents a comprehensive survey of the relevant legislation applicable in Germany to implementation of the EC Directive on environmental auditing. Readers interested in performing such auditing at one glance will find in this compiulation all relevant laws and regulations in full text that are to be observed for implementation of this novel environmental auditing instrument. (orig./RHM) [Deutsch] Diese Broschuere vermittelt einen umfassenden Ueberblick ueber die in Deutschland fuer die Ausfuehrung der EG-Umwelt-Audit-Verordnung geltenden Rechtsvorschriften. Damit wird fuer alle Interessenten ein rascher Zugriff auf die Rechtstexte, die zur praktischen Anwendung des neuartigen Umwelt-Audit-Instruments notwendig sind, ermoeglicht. (orig./RHM)

Near-Earth Asteroids 2006 RH120 AND 2009 BD: Proxies for Maximally Accessible Objects?

Science.gov (United States)

Barbee, Brent W.; Chodas, Paul W.

2015-01-01

NASA's Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) has identified over 1,400 of the approximately 12,800 currently known near-Earth asteroids (NEAs) as more astrodynamically accessible, round-trip, than Mars. Hundreds of those approximately 1,400 NEAs can be visited round-trip for less change-in-velocity than the lunar surface, and dozens can be visited round-trip for less change-in-velocity than low lunar orbit. How accessible might the millions of undiscovered NEAs be? We probe that question by investigating the hypothesis that NEAs 2006 RH120 and 2009 BD are proxies for the most accessible NEAs we would expect to find, and describing possible future NEA population model studies.

The BD Onclarity HPV assay on SurePath collected samples meets the International Guidelines for Human Papillomavirus Test Requirements for Cervical Screening

DEFF Research Database (Denmark)

Ejegod, Ditte; Bottari, Fabio; Pedersen, Helle

2016-01-01

This study describes a validation of the BD Onclarity HPV (Onclarity) assay using the international guidelines for HPV test requirements for cervical cancer screening of women 30 years and above using Danish SurePath screening samples. The clinical specificity (0.90, 95% CI: 0.88-0.91) and sensit......This study describes a validation of the BD Onclarity HPV (Onclarity) assay using the international guidelines for HPV test requirements for cervical cancer screening of women 30 years and above using Danish SurePath screening samples. The clinical specificity (0.90, 95% CI: 0.......88-0.91) and sensitivity (0.97, 95% CI: 0.87-1.0) of the Onclarity assay were shown to be non-inferior to the reference assay (specificity 0.90, 95% CI: 0.88-0.92, sensitivity 0.98, 95% CI: 0.91-1.0). The intra-laboratory reproducibility of Onclarity was 97% with a lower confidence bound of 96% (kappa value: 0...

Crossing Boundaries in Qualitative Research – Entwurf einer empirischen Reflexivität der qualitativen Sozialforschung in Deutschland und den USA

Directory of Open Access Journals (Sweden)

Stephanie Bethmann

2015-04-01

Full Text Available Der vorliegende Beitrag widmet sich der Analyse von Prozessen der Wissenskonstruktion in der qualitativen Sozialforschung im transatlantischen Vergleich. Basierend auf explorativen Forschungsergebnissen stellen wir mit den Idealtypen engaging und observing zwei Forschungsstile vor, die sich in den Praktiken der Konstruktion von Nähe und Distanz zum Gegenstand deutlich unterscheiden. Beides, Nähe und Distanz, wird dabei nicht als innere Haltung von Forschenden oder als rigoros nationaler Stil verstanden, sondern als Produkte konkreter Arbeitspraktiken, die in Zusammenhang mit nationalen Forschungskonventionen, Rahmenbedingungen und Epistemologien stehen. Gemeinsam ist beiden Interaktionsmustern die zentrale Fundierung im amerikanischen Pragmatismus, wobei die These einer auffallend unterschiedlichen Bezugnahme auf den amerikanischen Pragmatismus in den beiden Länderkontexten diskutiert wird: Stehen in Deutschland vorwiegend dessen erkenntnistheoretische Prämissen im Mittelpunkt, sieht sich die gegenwärtige US-amerikanische Methodenlandschaft eher dessen gesellschaftspolitischen Traditionen verpflichtet. Ausgehend von diesen Beobachtungen wird abschließend die Forderung formuliert, Reflexivität in der qualitativen Sozialforschung stärker auf den Boden empirischer Analysen zu stellen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1502191

Practical experience with biodegradable biomass waste bags in several different German composting plants; Praxiserfahrungen zum Abbau kompostierbarer Bioabfallsaecke auf verschiedenen Kompostierungsanlagen in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Ziermann, Andreas; Schmidt, Bettina [C.A.R.M.E.N. e.V., Straubing (Germany)

2012-11-01

The study intended to find out how fast biodegradable biomass waste bags are degraded in practical conditions in composting and fermentation plants. The plants differ with regard to the processes employed; further, rotting times may be much shorter in practice than the twelve weeks requested by DIN EN 13432 and DIN EN 14995. For the study, plant types were selected that are practically relevant for biomass waste utilisation in Germany. (orig.) [German] Ziel der vorliegenden Studie war es, herauszufinden, wie schnell kompostierbare Bioabfallsaecke unter Praxisbedingungen in verschiedenen Kompost- und Vergaerungsanlagentypen abgebaut werden. Zum einen bestehen teilweise grosse verfahrenstechnische Unterschiede zwischen den Anlagentypen, zum anderen sind die Rottezeiten in der Praxis zum Teil wesentlich kuerzer, als die in der DIN EN 13432 und DIN EN 14995 geforderten zwoelf Wochen. Fuer die Studie wurden Anlagentypen ausgewaehlt, die fuer die Verwertung von Bioabfaellen in Deutschland praxisrelevant sind. (orig.)

13 CFR 124.502 - How does an agency offer a procurement to SBA for award through the 8(a) BD program?

Science.gov (United States)

2010-01-01

... history, if any, of the requirement; (10) The names and addresses of any small business contractors which... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How does an agency offer a procurement to SBA for award through the 8(a) BD program? 124.502 Section 124.502 Business Credit and...

$B_d \\to K^*\\mu\\mu$ as a lab for discovering new physics at LHCb

CERN Document Server

Skottowe, H

2010-01-01

The analysis of the penguin decay $B_d \\to K^*\\mu\\mu$ at LHCb can act as a laboratory for the discovery and understanding of new physics. Through the Operator Product Expansion, the decay kinematics are well understood in both the Standard Model and in a large range of new physics scenarios. The theoretical errors from QCD effects can be characterized and a set of observables have been derived which minimise their influence in measurements. We will describe how these measurements can be made in LHCb with special emphasis on what can be done with a first run of the LHC with a few hundred pb$^{-1}$ of integrated luminosity.

[Therapeutic management of bipolar disorder in France and Europe: a multinational longitudinal study (WAVE-bd)].

Science.gov (United States)

Bellivier, F; Delavest, M; Coulomb, S; Figueira, M L; Langosch, J M; Souery, D; Vieta, E

2014-10-01

Bipolar disorder is a complex disease which requires multiple healthcare resources and complex medical care programs including pharmacological and non pharmacological treatment. If mood stabilizers remain the corner stone for bipolar disorder treatment, the development of atypical antipsychotics and their use as mood stabilizers has significantly modified therapeutic care. At the present time, psychiatrists have a large variety of psychotropic drugs for bipolar disorder: mood stabilizers, atypical antipsychotics, antidepressants, anxiolytics… However, despite the publication of guidelines on pharmacological treatment, with a high degree of consensus, everyday clinical practices remain heterogeneous. Moreover, there are few longitudinal studies to describe therapeutic management of bipolar disorder, whatever the phase of the disease is. Indeed, most of the studies are carried out on a specific phase of the disease or treatment. And there is no study comparing French and European practices. In this paper, we aim to present the comparison of the management of pharmacological treatments of bipolar disorder between France and Europe, using the data of the observational Wide AmbispectiVE study of the clinical management and burden of bipolar disorder (WAVE-bd study). The WAVE-bd study is a multinational, multicentre and non-interventional cohort study of patients diagnosed with BD type I or type II, according to DSM IV-TR criteria, in any phase of the disorder, who have experienced at least one mood event during the 12 months before enrolment. In total, 2507 patients have been included across 8 countries of Europe (480 in France). Data collection was retrospective (from 3 to 12 months), but also prospective (from 9 to 15 months) for a total study length of 12 to 27 months. Main outcome measures were the healthcare resource use and pharmacological treatments. Our results show differences in the therapeutic management of bipolar disorder between France and other European

Emission control measures for precursors of tropospheric ozone. Pt. 1 and 2; Emissionsminderungsmoeglichkeiten bei Vorlaeufersubstanzen von bodennahem Ozon. Bd. 1: Systemanalyse der Ozonminderungsmassnahmen in den USA. Bd. 2: Luftreinhaltemassnahmen in den USA zur Minderung von VOC-Emissionen aus Kleinanlagen und Produkten und Vergleich mit europaeischen Regelungen

Energy Technology Data Exchange (ETDEWEB)

Leclaire, T; Schiefer, C; Bergmann, S; Hrabovski, Z [Institut fuer Umwelttechnologie und Umweltanalytik e.V. (IUTA), Duisburg (Germany)

1998-08-01

emissions are compared and discussed. Advantages and disadvantages of the described strategies are highlighted. Based on the actual VOC emission inventory of Germany suggestions for future reduction measures are supposed. (orig.) [Deutsch] In den USA liegen Erfahrungen aus der Ozonbekaempfung ueber einen Zeitraum von 20 bis 30 Jahren vor. Aufgrund besonders hoher Ozonbelastungen in vielen Regionen werden grosse Anstrengungen zur VOC-Minderung unternommen. Wesentliches Ziel des Vorhabens war es, die Schwerpunkt im Hinblick auf die Minderung von VOC-Emissionen herauzufinden und zu pruefen, ob und inwieweit eine Uebertragung von Strategien und Massnahmen auf die Verhaeltnisse in Deutschland moeglich ist. Hauptaugenmerk wurde auf kleinere Anlagen und Produkte gelegt, weil in diesen Bereichen in Deutschland momentan vordringlich Handlungsbedarf gesehen wird. Im ersten Band sind die Strategien und Massnahmen zur Ozonminderung in den USA (bundesweit) sowie in fuenf Regionen mit besonders hoher Ozonimmissionsbelastung beschrieben. Hierzu erfolgte eine Darstellung der Zustaendigkeitsbereiche auf nationaler, einzelstaatlicher, regionaler und lokaler Ebene, der Gesetzgebung und Regelwerke, der Schwerpunktsetzung hinsichtlich NO{sub x}- und VOC-Minderung und eine kurze Darstellung der quellenbezogenen Massnahmen auf nationaler Ebene und in den betrachteten Regionen. In Band 2 erfolgt eine ausfuehrliche Beschreibung der Massnahmen zur VOC-Emissionsminderung bei Produkten und im gewerblichen Bereich in den USA anhand der nationalen Regelungen fuer Anstrichstoffe und Konsumgueter, der von der kalifornischen Luftreinhaltebehoerde erlassenen VOC-bezogenen Regelungen fuer Anstrichstoffe, Konsumgueter und Gewerbebetriebe sowie der Regelungen des suedkalifornischen South Coast Air Quality Management Districts (Los Angeles und Umgebung). Zur Darstellung der regionalen Bestimmung wurde diese Region ausgewaehlt, da die Regelungen dort aufgrund der besonders hohen Immissionsbelastung

Coal mining situation in the Federal Republic of Germany. Year 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Jahr 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-03-03

The paper reports on the coal mining in the Federal Republic of Germany in the year 2016. Statistical data are presented for coal market, brown coal mining as well as the hard coal mining. These data consider the supply and demand of coal in Germany, and employees of the German coal industry.

Coal mining situation in the Federal Republic of Germany. Year 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Jahr 2015

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-03-08

The paper reports on the coal mining in the Federal Republic of Germany in the year 2015. Statistical data are presented for coal market, brown coal mining as well as the hard coal mining. These data consider the supply and demand of coal in Germany, and employees of the German coal industry.

Coal mining situation in the Federal Republic of Germany. Year 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Jahr 2017

Energy Technology Data Exchange (ETDEWEB)

NONE

2018-03-12

The paper reports on the coal mining in the Federal Republic of Germany in the year 2017. Statistical data are presented for coal market, brown coal mining as well as the hard coal mining. These data consider the supply and demand of coal in Germany, and employees of the German coal industry.

Independent assessment of the TRAC-BD1/MOD1 computer code at the Idaho National Engineering Laboratory

International Nuclear Information System (INIS)

Wilson, G.E.; Charboneau, B.L.; Dallman, R.J.; Kullberg, C.M.; Wagner, K.C.; Wheatley, P.D.

1984-01-01

Under auspices of the United States Nuclear Regulatory Commission, their primary boiling water reactor safety analysis code (TRAC-BWR) is being assessed with simulations of a wide range of experimental data. The FY-1984 assessment activities were associated with the latest version (TRAC-BD1/MOD1) of this code. Typical results of the assessment studies are given. Conclusions formulated from these results are presented. These calculations relate to the overall applicability of the current code to safety analysis, and to future work which would further enhance the code's quality and ease of use

[Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung; B. 2 : Die Sicht auf Krieg, Diktat

Index Scriptorium Estoniae

Hecker-Stampehl, Jan

2011-01-01

Arvustus : Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung. Berlin : LIT Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 14); Bd. 2 : Die Sicht auf Krieg, Diktatur, Völkermord, Besatsung und Vertreibung in Russland, Polen und den baltischen Staaten. Berlin: Lit Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 15)

Mixing and CP-violation in the Bd and Bs systems at ATLAS

CERN Document Server

Wharton, Andrew Mark; The ATLAS collaboration

2016-01-01

Search for deviations from the standard model is performed in the systems of the neutral B mesons. The Bs system is studied in the decay into J/psi phi. The mixing phase phi_s and the width difference DeltaGamma_s are determined through the simultaneous study of angular distributions in the final state and of the decay time, performed together with flavour tagging at production. The measurement performed by ATLAS with the full LHC Run-1 sample is discussed and compared to the previous world average. The width difference DeltaGamma_d in the Bd system is obtained from the comparison of the decay time distributions in the flavour specific state J/psi K* and in the CP eigenstate J/psi KS. The result obtained from the full sample of data collected by ATLAS at 7 and 8 TeV is the most accurate single measurement of the width difference currently available.

Influence of centrifugation conditions on the results of 77 routine clinical chemistry analytes using standard vacuum blood collection tubes and the new BD-Barricor tubes.

Science.gov (United States)

Cadamuro, Janne; Mrazek, Cornelia; Leichtle, Alexander B; Kipman, Ulrike; Felder, Thomas K; Wiedemann, Helmut; Oberkofler, Hannes; Fiedler, Georg M; Haschke-Becher, Elisabeth

2018-02-15

Although centrifugation is performed in almost every blood sample, recommendations on duration and g-force are heterogeneous and mostly based on expert opinions. In order to unify this step in a fully automated laboratory, we aimed to evaluate different centrifugation settings and their influence on the results of routine clinical chemistry analytes. We collected blood from 41 healthy volunteers into BD Vacutainer PST II-heparin-gel- (LiHepGel), BD Vacutainer SST II-serum-, and BD Vacutainer Barricor heparin-tubes with a mechanical separator (LiHepBar). Tubes were centrifuged at 2000xg for 10 minutes and 3000xg for 7 and 5 minutes, respectively. Subsequently 60 and 21 clinical chemistry analytes were measured in plasma and serum samples, respectively, using a Roche COBAS instrument. High sensitive Troponin T, pregnancy-associated plasma protein A, ß human chorionic gonadotropin and rheumatoid factor had to be excluded from statistical evaluation as many of the respective results were below the measuring range. Except of free haemoglobin (fHb) measurements, no analyte result was altered by the use of shorter centrifugation times at higher g-forces. Comparing LiHepBar to LiHepGel tubes at different centrifugation setting, we found higher lactate-dehydrogenase (LD) (P = 0.003 to centrifuged at higher speed (3000xg) for a shorter amount of time (5 minutes) without alteration of the analytes tested in this study. When using LiHepBar tubes for blood collection, a separate LD reference value might be needed.

PHOTOIONIZATION MODELS OF THE INNER GASEOUS DISK OF THE HERBIG BE STAR BD+65 1637

Energy Technology Data Exchange (ETDEWEB)

Patel, P.; Sigut, T. A. A.; Landstreet, J. D., E-mail: ppatel54@uwo.ca [Department of Physics and Astronomy, The University of Western Ontario, London, Ontario Canada N6A 3K7 (Canada)

2016-01-20

We attempt to constrain the physical properties of the inner, gaseous disk of the Herbig Be star BD+65 1637 using non-LTE, circumstellar disk codes and observed spectra (3700–10500 Å) from the ESPaDOnS instrument on the Canada–France–Hawaii Telescope. The photoionizing radiation of the central star is assumed to be the sole source of input energy for the disk. We model optical and near-infrared emission lines that are thought to form in this region using standard techniques that have been successful in modeling the spectra of classical Be stars. By comparing synthetic line profiles of hydrogen, helium, iron, and calcium with the observed line profiles, we try to constrain the geometry, density structure, and kinematics of the gaseous disk. Reasonable matches have been found for all line profiles individually; however, no disk density model based on a single power law for the equatorial density was able to simultaneously fit all of the observed emission lines. Among the emission lines, the metal lines, especially the Ca ii IR triplet, seem to require higher disk densities than the other lines. Excluding the Ca ii lines, a model in which the equatorial disk density falls as 10{sup −10} (R{sub *}/R){sup 3} g cm{sup −3} seen at an inclination of 45° for a 50 R{sub *} disk provides reasonable matches to the overall line shapes and strengths. The Ca ii lines seem to require a shallower drop-off as 10{sup −10} (R{sub *}/R){sup 2} g cm{sup −3} to match their strength. More complex disk density models are likely required to refine the match to the BD+65 1637 spectrum.

Interkulturelle Kompetenz in der Facharztausbildung von Psychiatern in Deutschland: Ergebnisse einer Umfrage [Intercultural competence in the psychiatric training curriculum in Germany: Results of a survey

Directory of Open Access Journals (Sweden)

Machleidt, Wielant

2008-08-01

Psychiatrie und Psychotherapie in Deutschland. Methodik: Es wurde ein semistrukturierter Fragebogen mit 30 Fragen (davon 28 strukturiert, 2 mit Freitextangaben entwickelt, der sich an den „Local Survey of Realities in Transcultural Psychiatry“ der (APA anlehnt und für Deutschland modifiziert wurde. Dieser wurde an die Leiter aller psychiatrischen Weiterbildungsinstitutionen in Deutschland verschickt (n=450. Als psychiatrische Weiterbildungsinstitutionen wurden diejenigen klinischen Einrichtungen definiert, deren Leiter über eine Ermächtigung zur Facharztweiterbildung durch die Landesärztekammern verfügen. Der Rücklauf erfolgte nicht anonymisiert. Ergebnisse: Die Rücklaufquote betrug 25,5% (Gesamt-N=114. In 71,7% der Weiterbildungsinstitutionen (n=81/113 gültige Fälle wurden in der klinikinternen Weiterbildung Themen aus dem Gebiet der transkulturellen Psychiatrie selten oder gar nicht angesprochen. 83,3% der Weiterbildungsleiter (n=70/84 gültige Fälle formulierten Bedarf an Weiterbildung in transkultureller Psychiatrie für die jeweils eigene Institution, 94,5% (n=69/73 gültige Fälle sahen den Bedarf grundsätzlich auch für das Curriculum der Facharztausbildung in Psychiatrie und Psychotherapie. Die am häufigsten genannten Themen betrafen eine allgemeine Schulung kultureller Kompetenz sowie kulturspezifische Aspekte seelischer Erkrankungen. Schlussfolgerungen: Im Rahmen der Weiterbildungsordnung zum Facharzt für Psychiatrie und Psychotherapie sind aktuell in keinem Bundesland entsprechende Inhalte aus dem Bereich der transkulturellen Psychiatrie verankert. Angesichts des formulierten Bedarfs muss die Implementierung eines entsprechenden Curriculums in die Weiterbildungsordnung zum Facharzt für Psychiatrie und Psychotherapie diskutiert werden.

$B_{d} \\to K^{*0}\\mu^{+}\\mu^{-}$ as a lab for discovering new physics at LHCb

CERN Document Server

Skottowe, Hugh

2010-01-01

The analysis of the penguin decay Bd->K*MuMu at LHCb can act as a laboratory for the discovery and understanding of new physics. Through the Operator Product Expansion, the decay kinematics are well understood in both the Standard Model and in a large range of new physics scenarios. The theoretical errors from QCD effects can be characterized and a set of observables have been derived which minimise their influence in measurements. We will describe how these measurements can be made in LHCb with special emphasis on what can be done with a first run of the LHC with a few hundred pb-1 of integrated luminosity.

A roadmap to control penguin effects in B_d"0→J/ψK_S"0 and B_s"0→J/ψϕ

International Nuclear Information System (INIS)

Bruyn, Kristof De; Fleischer, Robert

2015-01-01

Measurements of CP violation in B_d"0→J/ψK_S"0 and B_s"0→J/ψϕ decays play key roles in testing the quark-flavour sector of the Standard Model. The theoretical interpretation of the corresponding observables is limited by uncertainties from doubly Cabibbo-suppressed penguin topologies. With continuously increasing experimental precision, it is mandatory to get a handle on these contributions, which cannot be calculated reliably in QCD. In the case of the measurement of sin 2β from B_d"0→J/ψK_S"0, the U-spin-related decay B_s"0→J/ψK_S"0 offers a tool to control the penguin effects. As the required measurements are not yet available, we use data for decays with similar dynamics and the SU(3) flavour symmetry to constrain the size of the expected penguin corrections. We predict the CP asymmetries of B_s"0→J/ψK_S"0 and present a scenario to fully exploit the physics potential of this decay, emphasising also the determination of hadronic parameters and their comparison with theory. In the case of the benchmark mode B_s"0→J/ψϕ used to determine the B_s"0-B-bar_s"0 mixing phase ϕ_s the penguin effects can be controlled through B_d"0→J/ψρ"0 and B_s"0→J/ψ ( K)-bar "∗"0 decays. The LHCb collaboration has recently presented pioneering results on this topic. We analyse their implications and present a roadmap for controlling the penguin effects.

Developing a model system for simulation of changes induced by more effective circular flow concepts in industry and energy management. Systems technology and economic modelling aspects shown with the example of the materials flow in the paper industry; Entwicklung eines Modellsystems zur Simulation der energiewirtschaftlichen und strukturellen Veraenderungen einer verstaerkten Kreislaufwirtschaft. Systemtechnische und oekonomische Modellierung am Beispiel des Stoffstroms 'Papier'

Energy Technology Data Exchange (ETDEWEB)

Nathani, C.

2000-02-01

The impacts of a long-term change from our present industrial society to an economy based on circular flow concepts approaching the characteristics of the concept of sustainable development have to be taken into account in macroeconomic modelling as well, or else there is no appropriate basis for examination and assessment of the effects of various resource management policy options on the economy. One possible methodological approach is to link single, process-oriented models of sectors of the industry with input-output models and macroeconomic models. This study presents an approach using as an example the pulp and paper industry of Germany, covering the period from 1995 until 2020. The results are found to improve the methodological perspective between the process models and the MIS model of the family of IKARUS models and also offer an additional advantage in that they may serve as a data source for other input-output models and macroeconomic modelling. (orig./CB) [German] Diese Einfluesse eines langfristigen Wandels von einer heutigen Industriegesellschaft zu einer Kreislaufwirtschaft mit Merkmalen einer nachhaltigen Entwicklung muessen sich auch in den Strukturen makrooekonomischer Modelle wiederfinden, um die Auswirkungen verschiedener ressourcenpolitischer Optionen auf die Wirtschaft angemessen pruefen zu koennen. Ein methodischer Weg zu dieser Aufgabe ist die Verknuepfung einzelner prozessorientierter Branchenmodelle mit Input-Output-Modellen und makrooekonomischen Modellen. Der vorliegende Bericht will hierzu einen Baustein am Beispiel der Zellstoff- und Papierindustrie fuer die Bundesrepublik Deutschland fuer die Zeitperiode 1995-2020 beitragen. Diese Ergebnisse verbessern nicht nur die methodische Perspektive zwischen den Prozessmodellen und dem MIS-Modell der IKARUS-Modellfamilie, sondern koennen als Erfahrungs- und Datenquelle fuer andere Input-Output-Modelle und makrooekonomische Modelle genutzt werden. (orig.)

Situation of coal mining in the Federal Republic of Germany. Year 2014; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Jahr 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-03-10

The paper reports on the coal mining in the Federal Republic of Germany in the year 2014. Statistical data are presented for coal market, brown coal mining as well as the hard coal mining. These data consider the supply and demand of coal in Germany, and employees of the German coal industry.

Forms of the cooperation principle in environmental law in the Federal Republic of Germany. Formen des Kooperationsprinzips im Umweltrecht der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Mueggenborg, H J

1990-01-01

The cooperation principle is not a legal principle, as in the case of the social state principle or the principle of the democratic constitutional state. In order that the cooperation principle may not degenerate to cheating and accompliceship, legal limitations are necessary. Work on this subject from the point of view of legal science has started late. The contribution investigates the various forms of the cooperation principle: Technical control boards as instruments to relieve the state; committees under private and public law for setting up technical standards, advisory bodies of public administration; organized hearings; environment protection officers in industry. It also investigates the legal admissibility of concerted actions, advantages and disadvantages, effects on legal protection, legal and actual conditions. - The positive sides of cooperation should succeed in order that environmental protection may profit. (orig./HP).

Studies on cadmium exposure in the population of the Federal Republic of Germany. Untersuchungen zur Cadmiumbelastung der Bevoelkerung in der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Ewers, U.

1990-01-01

The author reports on a number of studies performed on cadmium exposure in the population of the Federal Republic of Germany, in particular that of the Rhine-Ruhr region. The studies covered: - the examinations for Cd concentrations in full blood (CdB), in urine (CdU) in different population groups, and the analysis of various influencing factors; - an autopsy study involving 388 corpses from the Duesseldorf and Duisburg regions to determine the concentrations of cadmium, copper and zinc in the renal cortex - an epidemiological study on the occurrence and incidence of cadmium-induced renal function disorders in inhabitants of areas exposed to high Cd immission levels (Stolberg, Duisburg). The studies indicate CdB concentrations to be influenced by the following factors: - smoking; - age; - sex; - Cd immission level. Measurements of CdU concentrations were performed in children from Duisburg and Goch, and in women aged 65 and 66 from Stolberg, Duisburg and Duesseldorf. The results of the study performed in children did not reveal any influence of Cd immission levels. The results of the autopsy study showed that Cd concentrations in the renal cortex of persons not exposed to heavy metals occupationally, are well below the critical CdKc concentration on an average. The results of the epidemiological study on cadmium-induced renal function disorders in 286 women aged 65 and 66 from the cities of Stolberg, Duisburg and Duesseldorf revealed that no indications for renal dysfunctions clearly attributable to excessive Cd accumulation in the kidney, were verified even in a population group which had been exposed to relatively high Cd levels from the environment. (orig./MG).

Structure of and change in energy policy in the Federal Republic of Germany. Struktur und Wandel der Energiewirtschaft in der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Schiffer, H W

1985-01-01

The book offers a closed survey of the energy market in the F.R.G. It is based on a depiction of the organisational structure of the most important energy markets and also the price mechanisms for crude oil, electricity, natural gas and coal. The analysis also concentrates on the structural change which was occasioned by the first energy crisis in 1973 and accentuated by the second in 1979/80. It is suggested that the causes of desired energy-saving in industry, transport, and in the budgetary and consumer sectors lie in the price developments and the measures taken since 1973 via energy policy. It concludes, against a background of the predicted development, with an outline of current trends in energy policy, which is being increasingly influenced by enviromental questions.

Metabolic engineering of Pediococcus acidilactici BD16 for production of vanillin through ferulic acid catabolic pathway and process optimization using response surface methodology.

Science.gov (United States)

Kaur, Baljinder; Chakraborty, Debkumar; Kumar, Balvir

2014-10-01

Occurrence of feruloyl-CoA synthetase (fcs) and enoyl-CoA hydratase (ech) genes responsible for the bioconversion of ferulic acid to vanillin have been reported and characterized from Amycolatopsis sp., Streptomyces sp., and Pseudomonas sp. Attempts have been made to express these genes in Escherichia coli DH5α, E. coli JM109, and Pseudomonas fluorescens. However, none of the lactic acid bacteria strain having GRAS status was previously proposed for heterologous expression of fcs and ech genes for production of vanillin through biotechnological process. Present study reports heterologous expression of vanillin synthetic gene cassette bearing fcs and ech genes in a dairy isolate Pediococcus acidilactici BD16. After metabolic engineering, statistical optimization of process parameters that influence ferulic acid to vanillin biotransformation in the recombinant strain was carried out using central composite design of response surface methodology. After scale-up of the process, 3.14 mM vanillin was recovered from 1.08 mM ferulic acid per milligram of recombinant cell biomass within 20 min of biotransformation. From LCMS-ESI spectral analysis, a metabolic pathway of phenolic biotransformations was predicted in the recombinant P. acidilactici BD16 (fcs (+)/ech (+)).

Ecotoxicological sediment survey of large German rivers; Oekotoxikologische Sedimentkartierung der grossen Fluesse Deutschlands

Energy Technology Data Exchange (ETDEWEB)

Duft, M.; Tillmann, M. [Internationales Hochschulinstitut Zittau (Germany); Oehlmann, J. [Frankfurt Univ. (Germany). Zoologisches Inst., Abt. Oekologie und Evolution

2003-05-01

In this project, a nation-wide, ecotoxicologically-based sediment survey was carried out. For this purpose, a total of about 200 sediment samples from 12 selected large German rivers (Danube, Elbe, Ems, Main, Mosel, Neckar, Neisse, Odra, Rhine, Ruhr, Saar and Weser) were analysed with regard to abiotic parameters (heavy metals, PAH, organic carbon content, particle size) and also by means of two biological test systems with benthic invertebrates (nematode test with the roundworm Caenorhabditis elegans and chironomid test with the non-biting midge Chironomus riparius). Subsequently, this comprehensive data set was analysed statistically. By means of an iterative method, a five-stage, statistically-derived assessment concept which is founded on the results of the biological tests, was developed following the EU water framework directive. In general, the classification with the nematode test turned out to be the more sensitive method. A principal component analysis and correlations showed that the parameters of both biotests provide different information which suggests a combined use of both tests. Correlations also indicate a connection of biotest results and abiotic parameters (organic carbon content, particle size and heavy metal contamination). (orig.) [German] Im Projekt wurde eine bundesweite oekotoxikologische Sedimentkartierung grosser Fliessgewaesser durchgefuehrt. Dazu wurden insgesamt etwa 200 Sedimentproben aus 12 ausgewaehlten grossen Fluessen Deutschlands (Donau, Elbe, Ems, Main, Mosel, Neckar, Neisse, Oder, Rhein, Ruhr, Saar und Weser) auf ihre abiotischen Parameter (Schwermetalle, PAK, organischer Kohlenstoffgehalt, Korngroesse) hin analysiert sowie mit zwei biologischen Testverfahren mit benthischen Invertebraten (Nematodentest mit dem Fadenwurm Caenorhabditis elegans und Chironomidentest mit der Zuckmuecke Chironomus riparius) untersucht. Dieses umfangreiche Datenmaterial wurde anschliessend statistisch ausgewertet und mit Hilfe eines iterativen

Agrowaste to vanillin conversion by a natural Pediococcus acidilactici strain BD16.

Science.gov (United States)

Chakraborty, Debkumar; Kaur, Baljinder; Obulisamy, Karthikeyan; Selvam, Ammaiyappan; Wong, Jonathan W C

2017-07-01

Owing to its flavoring, antimicrobial, antioxidant and anticarcinogenic nature, vanillin is widely used in foods, beverages, perfumes and pharmaceutical products. Ferulic acid (FA) is an important precursor of vanillin which is abundant in cereals like maize, rice and wheat and sugar beet. A major drawback of microbial vanillin production from FA is the degradation and biotransformation of toxic vanillin to other phenolic derivatives. The present study is undertaken to explore microbial vanillin production from FA precursor rice bran by employing vanillin-resistant Pediococcus acidilactici BD16, a natural lactic acid bacteria isolate. Extracellular, intracellular and cellular vanillin dehydrogenase activity was found least, which was minimized vanillin degradation, and the strain resists more than 5 g L -1 vanillin in the medium. A metabolomics approach was followed for the detection of FA, vanillin and other metabolites generated during fermentation of rice bran medium. A metabolic pathway was also predicted for vanillin biosynthesis. Approximately 1.06 g L -1 of crude vanillin was recovered from rice-bran-containing medium and this further offers scope for the industrial utilization of the organism and its genetic manipulation to enhance production of biovanillin.

Premarket evaluations of the IMDx C. difficile for Abbott m2000 Assay and the BD Max Cdiff Assay.

Science.gov (United States)

Stellrecht, K A; Espino, A A; Maceira, V P; Nattanmai, S M; Butt, S A; Wroblewski, D; Hannett, G E; Musser, K A

2014-05-01

Clostridium difficile-associated diarrhea is a well-recognized complication of antibiotic use. Historically, diagnosing C. difficile has been difficult, as antigen assays are insensitive and culture-based methods require several days to yield results. Nucleic acid amplification tests (NAATs) are quickly becoming the standard of care. We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for the detection of C. difficile toxin genes, the IMDx C. difficile for Abbott m2000 Assay (IMDx) and the BD Max Cdiff Assay (Max). A prospective analysis of 111 stool specimens received in the laboratory for C. difficile testing by the laboratory's test of record (TOR), the BD GeneOhm Cdiff Assay, and a retrospective analysis of 88 specimens previously determined to be positive for C. difficile were included in the study. One prospective specimen was excluded due to loss to follow-up discrepancy analysis. Of the remaining 198 specimens, 90 were positive by all three methods, 9 were positive by TOR and Max, and 3 were positive by TOR only. One negative specimen was initially inhibitory by Max. The remaining 95 specimens were negative by all methods. Toxigenic C. difficile culture was performed on the 12 discrepant samples. True C. difficile-positive status was defined as either positive by all three amplification assays or positive by toxigenic culture. Based on this definition, the sensitivity and specificity were 96.9% and 95% for Max and 92.8% and 100% for IMDx. In summary, both highly automated systems demonstrated excellent performance, and each has individual benefits, which will ensure that they will both have a niche in clinical laboratories.

Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

Directory of Open Access Journals (Sweden)

Francesca Sanguineti

2008-12-01

Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

Status report on the use of nuclear energy in the Federal Republic of Germany 2013; Statusbericht zur Kernenergienutzung in der Bundesrepublik Deutschland 2013

Energy Technology Data Exchange (ETDEWEB)

Bredberg, Ines; Hutter, Johann; Kuehn, Kerstin; Niedzwiedz, Katarzyna; Philippczyk, Frank; Dose, Julia

2014-08-15

This report describes the use of nuclear energy in the Federal Republic of Germany as of 31 December, 2013. It contains the essential data of all nuclear power plants, research reactors and the facilities of the nuclear fuel cycle. At the reporting moment 31{sup st} of December in 2013, nine nuclear power plants were still in operation. The power generation from nuclear energy in 2013 amounted to 97.3 TWh (2012: 99.5 TWh). It is a share of 15.4 % of the total gross electricity production (2012: 15.8 %). The report summarizes the essential operational results of the nuclear power plants and information on granted licenses. A short description of the present state of the nuclear power plants that have been shut down or decommissioned and of the stopped projects is given. Concerning research reactors essential data on type, characteristics (thermal power, thermal neutron flux) and purpose of the facility are represented. Furthermore, an overview about the licensing and operation history and the present state of the operating condition is given. For the facilities of the nuclear fuel cycle data on purpose and capacity, the licensing history and the present state of operation and licensing are given. The current status of repository projects (ERAM and Konrad) Asse mine and the Gorleben site is presented. To give a survey, the data are summarized in tabular form in the report annexes. The report will be updated and published once a year. Due to the government reshuffle and the changed portfolio of some federal ministries, the former Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) was renamed to Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) on 17 December 2013.

Status report on the use of nuclear energy in the Federal Republic of Germany 2014; Statusbericht zur Kernenergienutzung in der Bundesrepublik Deutschland 2014

Energy Technology Data Exchange (ETDEWEB)

Bredberg, Ines; Hutter, Johann; Kuehn, Kerstin; Niedzwiedz, Katarzyna; Philippczyk, Frank; Thoemmes, Achim

2015-05-15

This report describes the use of nuclear energy in the Federal Republic of Germany as at 31 December 2014. It contains the essential data of all nuclear power plants, research reactors and the facilities of the nuclear fuel cycle. At the reporting date 31 December 2014, nine nuclear power plants were in operation. The power generation from nuclear energy in 2014 amounted to altogether 97.1 TWh (2013: 97.3 TWh). This is a share of 15.8% of the total gross electricity production (2013: 15.4%)1. The report summarises the essential operational results of the nuclear power plants and information on granted licences. A short description of the present state of the nuclear power plants that have been shut down or decommissioned and of the stopped projects is given. Concerning research reactors essential data on type, characteristics (thermal power, thermal neutron flux) and purpose of the facility are represented. Furthermore, an overview is given of the licensing and operation history and the present state of the operating condition. For the facilities of the nuclear fuel cycle data on purpose and capacity and output are given. Furthermore, the licensing history and the present status of operation and licensing are represented. The works on the running repository projects ERAM and Konrad and on the Asse II mine and the Gorleben mine are presented. To give a survey, the data is summarised in tabular form at the end of the report (Annexes). The report is updated and published once a year.

Status report on the use of nuclear energy in the Federal Republic of Germany 2015; Statusbericht zur Kernenergienutzung in der Bundesrepublik Deutschland 2015

Energy Technology Data Exchange (ETDEWEB)

Bredberg, Ines; Hutter, Johann; Kuehn, Kerstin; Niedzwiedz, Katarzyna; Philippczyk, Frank; Thoemmes, Achim

2016-05-15

Status report on the use of nuclear energy in the Federal Republic of Germany 2015 covers the following topics: electricity generation on Germany, nuclear power plants in Germany, research reactors, facilities of nuclear fuel supply and nuclear waste management.

Nina Bauer, Jens Luedtke (Hg.: Die soziale Konstruktion von Männlichkeit. Hegemoniale und marginalisierte Männlichkeiten in Deutschland. Opladen u.a.: Verlag Barbara Budrich 2008.

Directory of Open Access Journals (Sweden)

Katharina Pühl

2009-11-01

Full Text Available Der Band versammelt neuere, vorwiegend empirisch basierte Beiträge aus der Geschlechterforschung der Soziologie. Im Fokus stehen die Konstruktionsprozesse hegemonialer Männlichkeiten im Kontext gesellschaftlicher Transformationsprozesse in Deutschland. Forschungsperspektiven für zukünftige wissenschaftliche Studien werden benannt, allen voran die Notwendigkeit, in einem stärkeren Maße eine intersektionale Perspektive einzunehmen, die die Diskurse der kritischen feministischen Genderforschung noch mehr als bisher für die Männerforschung produktiv machen könnte.The volume collects newer, primarily empirically based articles presenting gender research in sociology. The focus remains on processes of construction of hegemonic masculinities in the context of social processes of transformation in Germany. The volume represents the state of German-language discussions with regard to analysis of masculinities. It identifies research perspectives for future academic studies, especially highlighting the necessity to increasingly include an intersectional perspective that could make the discourses of critical feminist gender research even more productive for masculinity research that currently is the case.

Von Zetteln und Apparaten. Subjektivierung in bundesdeutschen und britischen Arbeitsämtern der 1970er- und 1980er-Jahre

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Wiebke Wiede

2016-11-01

Full Text Available The article examines the governance of unemployment by employment offices inthe Federal Republic of Germany and the United Kingdom in the 1970s and 1980s, which were times of persisting mass unemployment in both countries, focusing on social meanings encoded into the social space of employment offices. Applying concepts from actor-network theory, the article investigates the agency of things in the administration of unemployment, e.g. folders of files, queue numbers or vacancy notices. In particular, the article considers the mechanisation and increasing use of machines and IT systems in German and British employment offices. With regard to processes of subjectivisation, it investigates how the unemployed experienced things and objects in employment offices. While the newly designed British Jobcentre offered jobs as part of a self-service concept, the German employment offices remained in the bureaucratic tradition whereby the unemployed primarily waited for employment counselling and placement. Der Beitrag untersucht Arbeitsämter in der Bundesrepublik Deutschland und Großbritannien während der 1970er- und 1980er-Jahre, einer Zeit deutlich gestiegener Arbeitslosenzahlen. Im Fokus stehen die Verwaltungsvorgänge, begriffen als soziale Praktiken und Mensch-Ding-Verhältnisse. Mit der Akteur-Netzwerk-Theorie fragt der Aufsatz nach der Agency der Verwaltungsdinge im Arbeitsamt: den Bürogestaltungen, Aktenordnern, Wartenummern oder Stellenaushängen. Problematisiert wird besonders die in den 1970er- und 1980er-Jahren durchgesetzte Technisierung der administrativen Vorgänge, also der vermehrte Einsatz von Apparaten und EDV-Systemen in bundesdeutschen und britischen Arbeitsverwaltungen. In beiden Ländern wurde »Selbstbedienung« zu einem neuen Verhaltensdispositiv, das sich in den neu eingerichteten britischen Jobcentres jedoch schneller durchsetzte als im traditionellen deutschen Arbeitsamt, wo das passive Warten weiterhin eine vorherrschende

Pflege – eine Sache der ganzen Familie Care—An Issue for the Whole Family

Directory of Open Access Journals (Sweden)

Nicole Maly-Lukas

2005-07-01

Full Text Available Derzeit sind in der Bundesrepublik Deutschland ca. 2 Millionen Menschen pflegebedürftig. Etwa 1,4 Millionen werden im häuslichen Bereich – in der Regel von Familienmitgliedern gepflegt – z. T. mit professioneller Unterstützung. Die Familie ist also weiterhin „der größte Pflegedienst der Nation“. Und es sind hauptsächlich die Frauen, die sich für die Pflege von Familienmitgliedern verantwortlich fühlen. Gröning et al. möchten sich in ihrem Buch In guten wie in schlechten Tagen aber nicht auf die Belastungen der pflegenden Frauen beschränken. Sie stellen die Generationen- und Geschlechterbeziehungen, die einen großen Einfluss auf die familiäre Pflegebeziehung haben, in den Vordergrund. In dem Buch Pflegegeschichten kommen rund 40 pflegende Angehörige selbst zu Wort, indem sie ‚ihre‘ persönliche „Pflegegeschichte“ erzählen.At this time in the Federal Republic of Germany around two million people are in need of care. Around 1.4 million of these are cared for at home—for the most part by family members—partly with professional support. The family thus continues to be “the largest nursing service in the nation.” And it is mostly women who feel responsible for the care of family members. The editors do not wish to limit themselves only to the pressures on the care-giving women in their book In guten wie in schlechten Tagen (In Sickness and in Health. They place in the foreground generational and gendered relationships that have a great influence on familial nursing relationships. In the book Pflegegeschichten (Nursing Stories around 40 care-giving relatives speak for themselves by telling their “own” personal “nursing stories.”

Multi-band high resolution spectroscopy rules out the hot Jupiter BD+20 1790b. First data from the GIARPS Commissioning

Science.gov (United States)

Carleo, I.; Benatti, S.; Lanza, A. F.; Gratton, R.; Claudi, R.; Desidera, S.; Mace, G. N.; Messina, S.; Sanna, N.; Sissa, E.; Ghedina, A.; Ghinassi, F.; Guerra, J.; Harutyunyan, A.; Micela, G.; Molinari, E.; Oliva, E.; Tozzi, A.; Baffa, C.; Baruffolo, A.; Bignamini, A.; Buchschacher, N.; Cecconi, M.; Cosentino, R.; Endl, M.; Falcini, G.; Fantinel, D.; Fini, L.; Fugazza, D.; Galli, A.; Giani, E.; González, C.; González-Álvarez, E.; González, M.; Hernandez, N.; Hernandez Diaz, M.; Iuzzolino, M.; Kaplan, K. F.; Kidder, B. T.; Lodi, M.; Malavolta, L.; Maldonado, J.; Origlia, L.; Ventura, H. Perez; Puglisi, A.; Rainer, M.; Riverol, L.; Riverol, C.; San Juan, J.; Scuderi, S.; Seemann, U.; Sokal, K. R.; Sozzetti, A.; Sozzi, M.

2018-05-01

Context. Stellar activity is currently challenging the detection of young planets via the radial velocity (RV) technique. Aims: We attempt to definitively discriminate the nature of the RV variations for the young active K5 star BD+20 1790, for which visible (VIS) RV measurements show divergent results on the existence of a substellar companion. Methods: We compare VIS data with high precision RVs in the near-infrared (NIR) range by using the GIANO-B and IGRINS spectrographs. In addition, we present for the first time simultaneous VIS-NIR observations obtained with GIARPS (GIANO-B and HARPS-N) at Telescopio Nazionale Galileo (TNG). Orbital RVs are achromatic, so the RV amplitude does not change at different wavelengths, while stellar activity induces wavelength-dependent RV variations, which are significantly reduced in the NIR range with respect to the VIS. Results: The NIR radial velocity measurements from GIANO-B and IGRINS show an average amplitude of about one quarter with respect to previously published VIS data, as expected when the RV jitter is due to stellar activity. Coeval multi-band photometry surprisingly shows larger amplitudes in the NIR range, explainable with a mixture of cool and hot spots in the same active region. Conclusions: In this work, the claimed massive planet around BD+20 1790 is ruled out by our data. We exploited the crucial role of multi-wavelength spectroscopy when observing young active stars: thanks to facilities like GIARPS that provide simultaneous observations, this method can reach its maximum potential.

A common variant of staphylococcal cassette chromosome mec type IVa in isolates from Copenhagen, Denmark, is not detected by the BD GeneOhm methicillin-resistant Staphylococcus aureus assay

DEFF Research Database (Denmark)

Bartels, Mette Damkjaer; Boye, Kit; Rohde, Susanne Mie

2009-01-01

Rapid tests for detection of methicillin-resistant Staphylococcus aureus (MRSA) carriage are important to limit the transmission of MRSA in the health care setting. We evaluated the performance of the BD GeneOhm MRSA real-time PCR assay using a diverse collection of MRSA isolates, mainly from Cop...

Application of recombinant Pediococcus acidilactici BD16 (fcs +/ech +) for bioconversion of agrowaste to vanillin.

Science.gov (United States)

Chakraborty, Debkumar; Selvam, Ammaiyappan; Kaur, Baljinder; Wong, Jonathan Woon Chung; Karthikeyan, Obulisamy Parthiba

2017-07-01

Biotechnological production of vanillin is gaining momentum as the natural synthesis of vanillin that is very expensive. Ferulic acid (FA), a costly compound, is used as the substrate to produce vanillin biotechnologically and the making process is still expensive. Therefore, this study investigated the practical use of an agrobiomass waste, rice bran, and provides the first evidence of a cost-effective production of vanillin within 24 h of incubation using recombinant Pediococcus acidilactici BD16 (fcs + /ech + ). Introduction of two genes encoding feruloyl CoA synthetase and enoyl CoA hydratase into the native strain increased vanillin yield to 4.01 g L -1 . Bioconversion was monitored through the transformation of phenolic compounds. A hypothetical metabolic pathway of rice bran during the vanillin bioconversion was proposed with the inserted pathway from ferulic acid to vanillin and compared with that of other metabolic engineered strains. These results could be a gateway of using recombinant lactic acid bacteria for industrial production of vanillin from agricultural waste.

Gausbert de Poicibot, “Be·s cuget venjar Amors” (BdT 173.2

Directory of Open Access Journals (Sweden)

Francesca Andolfato

2010-09-01

Full Text Available This paper offers a commentary and a new critical edition of Gausbert de Poicibot’s poem “Be·s cuget venjar Amors”, which apparently belongs to the genre of the ‘mala chanso’, that was particularly popular during the period that the Limousin poet was active. To abandon love enables the poet to recuperate reason and ‘sen’ and to justify, almost in didactic terms, his separation from the lady, thus clearly showing that he had so far sung the praises of a lady who was not worthy of receiving them. The song is also compared to other typical examples of the subgenre to which it belongs, such as “Si be·m partetz, mala dompna, de vos” by Gui d’Uissel (BdT 194.19, considered to be paradigmatic of the ‘mala chanso’ and probably familiar to Gausbert de Poicibot, though it will be pointed out that this poetic mode has roots in the work of troubadours of previous generations, such as Bernart de Ventadorn and Raimbaut d’Aurenga, whom Gausbert seems to use as models.

Der Fall Wal-Mart : institutionelle Grenzen ökonomischer Globalisierung

OpenAIRE

Senge, Konstanze

2004-01-01

"In dem Text werden Gründe für die gescheiterte Expansionsstrategie des weltgrößten Einzelhandelsunternehmens Wal-Mart nach Deutschland diskutiert. Differenziert werden vor allem drei Fehlerquellen: So hat Wal-Mart die ökonomischen, politischen und kulturellen Besonderheiten in Deutschland nicht ausreichend beachtet. Zur Erklärung der Situation Wal-Marts in Deutschland wird das Modell des soziologischen Neo-Institutionalismus herangezogen, insbesondere wird auf die Konzepte 'Legitimität' und ...

Der Fall Wal-Mart

OpenAIRE

Senge, Konstanze

2004-01-01

In dem Text werden Gründe für die gescheiterte Expansionsstrategie des weltgrößten Einzelhandelsunternehmens Wal-Mart nach Deutschland diskutiert. Differenziert werden vor allem 3 Fehlerquellen: So hat Wal-Mart die ökonomischen, politischen und kulturellen Besonderheiten in Deutschland nicht ausreichend beachtet. Zur Erklärung der Situation Wal-Marts in Deutschland wird das Modell des soziologischen Neo-Institutionalismus herangezogen, insbesondere wird auf die Konzepte Legitimität und Iso...

Summarizing report on results obtained by institutions in Germany and Switzerland applying high-resolution detectors for health physics monitoring; Zusammenfassender Bericht ueber die Inkorporationsmessstellen mit hochaufloesenden Detektoren in Deutschland und der Schweiz

Energy Technology Data Exchange (ETDEWEB)

Sahre, P. [Verein fuer Kernverfahrenstechnik und Analytik Rossendorf e.V., Dresden (Germany)

1997-12-01

In order to gather as much information as possible about the performance of high-resolution detectors in whole-body and partial-body counters, a questionnaire was distributed to those health physics monitoring institutions in Germany and Switzerland known to apply such instruments. The inquiry also covered institutions in Prague, Budapest, and Seibersdorf which participate in activities of the AKI. The results of the inquiry are given in tabulated form. (orig./CB) [Deutsch] Um moeglichst viele Informationen ueber Ganz- und Teilkoerperzaehler, die mit hochaufloesenden Detektoren arbeiten, zu erfassen, wurde an alle in Deutschland und in der Schweiz arbeitenden Inkorporationsmessstellen ein Formular zur Erfassung von Erfahrungen mit hochaufloesenden Detektoren gesendet. In die Abfrage einbezogen wurden auch Messstellen aus Prag, Budapest und Seibersdorf, die im AKI involviert sind. Die Ergebnisse der Umfrage fuer Ganzkoerperzaehler und fuer Teilkoerperzaehler werden tabellarisch zusammengefasst. (orig./SR)

Particle reduction strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. PM10- and NO{sub 2}-immission contributions in Germany. Wood combustion in small combustion systems; installations of the 13th and 17th BImSchV (Federal Immission Control Act). Sub-report.; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. PM10- und NO{sub 2}-Immissionsbeitraege in Deutschland. Holzverbrennung in Kleinfeuerungsanlagen, Anlagen der 13. und 17. BImSchV. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

2013-06-15

This report was prepared within the research project ''Particle reduction strategies - PAREST.'' In this paper with the chemical transport model REM CALGRID following questions were investigated: 1 What is the contribution of the wood-fired small combustion plants in Germany to the PM10- and NO {sub 2}-concentrations? 2 What is the contribution of the 13th and 17th BlmSchV covered installations to the PM10 and NO{sub 2} concentrations in Germany? [German] Der vorliegende Bericht wurde im Rahmen des Forschungs- und Entwicklungsvorhabens ''Strategien zur Verminderung der Feinstaubbelastung'' erstellt. In dem Beitrag werden mit dem chemischen Transportmodell REM-CALGRID folgende Fragestellungen untersucht: 1. Wie hoch ist der Beitrag der mit Holz beheizten Kleinfeuerungsanlagen in Deutschland zu den PM10- und den NO{sub 2}-Konzentrationen? 2. Wie hoch ist der Beitrag der von der 13. und 17. BImSchV erfassten Anlagen zu den PM10-und NO-2-Konzentrationen in Deutschland?.

Long-Term Stability of Human Genomic and Human Papillomavirus DNA Stored in BD SurePath and Hologic PreservCyt Liquid-Based Cytology Media

Science.gov (United States)

Agreda, Patricia M.; Beitman, Gerard H.; Gutierrez, Erin C.; Harris, James M.; Koch, Kristopher R.; LaViers, William D.; Leitch, Sharon V.; Maus, Courtney E.; McMillian, Ray A.; Nussbaumer, William A.; Palmer, Marcus L. R.; Porter, Michael J.; Richart, Gregory A.; Schwab, Ryan J.

2013-01-01

We evaluated the effect of storage at 2 to 8°C on the stability of human genomic and human papillomavirus (HPV) DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media. DNA retained the ability to be extracted and PCR amplified for more than 2.5 years in both medium types. Prior inability to detect DNA in archived specimens may have been due to failure of the extraction method to isolate DNA from fixed cells. PMID:23678069

Avaliku õiguse ajaloo uurimisest Saksamaal 20. sajandi lõpul / Peeter Järvelaid

Index Scriptorium Estoniae

Järvelaid, Peeter, 1957-

1999-01-01

Ülevaade raamatutest: Willoweit, Dietmar. Deutsche Verfassungsgeschichte. Vom Frankenreich bis zur Wiedervereinigung Deutschlands. Ein Studienbuch. 3. Aufl. München, 1997 ; Stolleis, Michael. Geschichte des öffentlichen Rechts in Deutschland. München, 1999

Sound-tracking Germany: 70 years of imagining the nation from Schlager to Techno

NARCIS (Netherlands)

Schiller, M.M.

2016-01-01

In the mid-seventies, Kraftwerk asked, "What is the sound of the German Bundesrepublik?" and answered with their international über-hit "Autobahn". In the eighties, Deutsch Amerikanische Freundschaft [DAF] ordered the dance-obsessed New German Wave youth to "shake your ass and do the Adolf Hitler!"

First intermediate break test 6IB1 data comparison with a TRAC-BD1/MOD1 blind calculation

International Nuclear Information System (INIS)

Wheatley, P.D.

1985-04-01

TRAC-BD1/MOD1 has been used to calculate the behavior in the FIST (Full Integral Test Facility) facility during an intermediate break in one of the recirculation loops. Results of the calculation are compared with the data from the experiment, and the analysis is discussed in this report. The calculation was blind with only the initial and boundary conditions available prior to performance of the calculation. The calculation has been previously documented without reference to the experimental data (i.e., prior to release of the data). This report extends the prior report by discussing the analysis of the data to code comparisons. This work was performed as part of the Nuclear Regulatory Commission's support to the FIST program which is being provided at the Idaho National Engineering Laboratory

The production of biofuels in Germany. State of the art and optimization approaches; Die Biokraftstoffproduktion in Deutschland. Stand der Technik und Optimierungsansaetze

Energy Technology Data Exchange (ETDEWEB)

Braune, Maria; Groengroeft, Arne [DBFZ Deutsches Biomasseforschungszentrum gemeinnuetzige GmbH, Leipzig (Germany); Oehmichen, Katja; Zech, Konstantin

2015-07-01

Determining the status quo of existing biofuel plants in Germany, an extensive database of process configurations was received. This information was used to develop simulation models of virtual biofuel plants, which are now available for further investigations. The GHG emissions of biofuels can partly be improved by the studied optimization approaches. The studied optimization approaches can hence contribute to the increasing requirements for GHG reductions of biofuels. The integration of multiple optimization approaches in one concept would improve its GHG balance further. In addition to the investigated technical measures, emissions could also be reduced by adapting the energy supply. The use of biofuels for heat generation, for example, could have an additional reducing effect on total GHG emissions, because a fossil fuel-based heat and electricity supply is the main driver of the GHG balance. From the communication with contacts in the industry it can be said that the German biofuel industry operates production plants that have already reached a high level of efficiency. At many locations, additional measures and modifications are planned, not only driven by economic reasons but also to further improve the GHG balance. The overall results of the project will be published as DBFZ Report No. 22 ''Die Biokraftstoffproduktion in Deutschland - Stand der Technik und Optimierungsansaetze'' in 2015.

Rotary-Wing Brownout Mitigation: Technologies and Training (Remedes contre le phenomene de brownout sur les appareils a voilure tournante: Technologies et entrainement)

Science.gov (United States)

2012-01-01

thorstenwernereger@bundeswehr.org Mr. Peter KIELHORN EADS Deutschland GmbH P.O. Box 88039 Friedrichshafen E-mail: peter.kielhorn...Deutschland GmbH P.O. Box 88039 Friedrichshafen E-mail: thomas.muensterer@cassidian.com ISRAEL Mr. Ofer KLEIN Elbit Systems Aerospace Adv. Tech

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor

Directory of Open Access Journals (Sweden)

Sandra Posch

2016-09-01

Full Text Available We here give information for a deeper understanding of single molecule force spectroscopy (SMFS data through the example of the blood protein von Willebrand factor (VWF. It is also shown, how fitting of rupture forces versus loading rate profiles in the molecular dynamics (MD loading-rate range can be used to demonstrate the qualitative agreement between SMFS and MD simulations. The recently developed model by Bullerjahn, Sturm, and Kroy (BSK was used for this demonstration. Further, Brownian dynamics (BD simulations, which can be utilized to estimate the lifetimes of intramolecular VWF interactions under physiological shear, are described. For interpretation and discussion of the methods and data presented here, we would like to directly point the reader to the related research paper, “Mutual A domain interactions in the force sensing protein von Willebrand Factor” (Posch et al., 2016 [1]. Keywords: Atomic force microscopy, Single molecule force spectroscopy, Molecular dynamics simulation, Brownian dynamics simulation, von Willebrand factor

Mixed-oxide (MOX) fuel performance benchmark. Summary of the results for the PRIMO MOX rod BD8

International Nuclear Information System (INIS)

Ott, L.J.; Sartori, E.; Costa, A.; ); Sobolev, V.; Lee, B-H.; Alekseev, P.N.; Shestopalov, A.A.; Mikityuk, K.O.; Fomichenko, P.A.; Shatrova, L.P.; Medvedev, A.V.; Bogatyr, S.M.; Khvostov, G.A.; Kuznetsov, V.I.; Stoenescu, R.; Chatwin, C.P.

2009-01-01

The OECD/NEA Nuclear Science Committee has established an Expert Group that deals with the status and trends of reactor physics, nuclear fuel performance, and fuel cycle issues related to the disposition of weapons-grade plutonium as MOX fuel. The activities of the NEA Expert Group on Reactor-based Plutonium Disposition are carried out in close cooperation with the NEA Working Party on Scientific Issues in Reactor Systems (WPRS). A major part of these activities includes benchmark studies. This report describes the results of the PRIMO rod BD8 benchmark exercise, the second benchmark by the TFRPD relative to MOX fuel behaviour. The corresponding PRIMO experimental data have been released, compiled and reviewed for the International Fuel Performance Experiments (IFPE) database. The observed ranges (as noted in the text) in the predicted thermal and FGR responses are reasonable given the variety and combination of thermal conductivity and FGR models employed by the benchmark participants with their respective fuel performance codes

Analysis of the current cost situation of wind power in Germany; Untersuchungen der aktuellen Kostensituation der Windenergienutzung in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Rehfeldt, K. [Deutsches Windenergie-Inst. Sucursal en Espana, Pamplona (Spain); Schwenk, B. [InnoVent GmbH, Varel (Germany)

2000-07-01

Against the background of the discussion concerning the Reimbursement Act (StrEG) and the draft Renewable Energy Sources Act (EEG), the Bundesverband Windenergie e.V. (BWE) asked the Deutsches Windenergie-Institut (DEWI) to investigate the current cost situation of wind power in Germany. This involved a statistics of wind power generation cost over a period of 20 years. The data were obtained from wind power system operators, technical experts, producers of wind power systems and insurance companies. It was found that especially the cost of component replacement was higher than expected, so that long component life must be one of the main goals in the further development of wind power systems. According to the technical experts, component life today is much less than the rated life of 20 years. [German] Vor dem Hintergrund der Diskussion um das Stromeinspeisegesetz (StrEG) bzw. des Neuentwurfs zum Erneuerbare-Energien-Gesetz (EEG) wurde das Deutsche Windenergie-Institut (DEWI) vom Bundesverband Windenergie e.V. (BWE) beauftragt, eine Studie ueber die aktuelle Kostensituation in Deutschland zu erarbeiten. Erstmals wurden hierbei Stromerzeugungskosten aus Windenergieanlagen (WEA) ueber einen Zeitraum von 20 Jahren ermittelt. Hierbei wurden Umfrageergebnisse von Betreibern von WEA, technischen Sachverstaendigen sowie von Herstellern von WEA und Versicherungsgesellschaften verwendet, um belastbare Aussagen ueber Betriebskosten und notwendige Ersatzinvestitionen zu erhalten. Insbesondere die Aussagen ueber notwendige Ersatzinvestitionen durch die technischen Sachverstaendigen waren hoeher als erwartet, so dass es in Zukunft Ziel sein muss, insbesondere bei der Weiterentwicklung von WEA auf wesentlich laengere Lebensdauern der Bauteilkomponenten von WEA zu draengen. Nach Aussage der technischen Sachverstaendigen liegen bisher die Lebensdauern wesentlicher Bauteile der WEA, wie Rotor, Bremssystem, Pitchregelung usw., weit unter der kalkulierten Lebensdauer von 20 Jahren

Exemplary subsurface geothermal projects in the western part of Germany; Beispiele zur Nutzung oberflaechennaher Geothermie im Westen Deutschlands

Energy Technology Data Exchange (ETDEWEB)

Sanner, B.; Mands, E. [UbeG GbR, Wetzlar (Germany); Kohlsch, O. [EWS Erdwaerme-Systemtechnik GmbH, Delbrueck (Germany)

2004-12-01

During the past few years, several projects involving ground source heat pumps were carried out in western Germany, especially in the Rhine-Main and Rhine-Ruhr-Sieg region including the cities of Frankfurt and Cologne. Some of the project partners are big names in industry, e.g. an office building of PhilipsSparte APD at Wetzlar and the museum building of chocolate producer Ritter Sport. Other projects are sited in rural regions, from the Black Forest to the Weserbergland hills. The contribution presents several interesting projects, e.g. the police headquarters building at Bonn (right bank, groundwater use) and the office building of the Federal Office of Environmental protection, also at Bonn (left bank, geothermal probles), and three school buildings in the Frankfurt/Main region at Glashuetten, Bad Homburg-Oberstedten and Usingen-Eschbach. (orig.) [German] In den letzten Jahren wurden im Westen Deutschlands eine ganze Reihe groesserer Projekte mit erdgekoppelten Waermepumpen verwirklicht, besonders im Rhein-Main-Gebiet und im Rhein-Ruhr-Sieg-Gebiet einschliesslich der Grossstaedte Frankfurt und Koeln. Zu den Bauherren zaehlen inzwischen auch bekannte Namen der deutschen Industrie. So wird in Wetzlar ein Buerogbaeude der PhilipsSparte APD mit Erdwaermesonden ausgeruestet, und das Museum des Schokoladenherstellers Ritter Sport wird auf Energiepfaehlen stehen. Abe auch im laendlichen Raum sind interessante Anlagen entstanden, vom Schwarzwald bis ins Weserbergland. Im Folgenden werden einige interessante Beispiele vorgestellt. Dabei sind Projekte in der Ausfuehrungsphase wie z.B. das Polizeipraesidium in Bonn (rechts des Rheins mit Grundwassernutzung), oder das Bundesamt fuer Naturschutz in Bonn, diesmal auf der linken Rheinseite und mit Erdwaermesonden. In Ausfuehrungn bzw. fertiggestellt sind auch Erdwaermesonden fuer 3 Schulen im Raum Frankfurt:/Main, in Glashuetten, Bad Homburg-Oberstedten und Usingen-Eschbach. (orig.)

Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion.

Science.gov (United States)

Chang, Nakho; Lee, Hye Won; Lim, Joung Eun; Jeong, Da Eun; Song, Hye Jin; Kim, Sudong; Nam, Do-Hyun; Sung, Hyun Hwan; Jeong, Byong Chang; Seo, Seong Il; Jeon, Seong Soo; Lee, Hyun Moo; Choi, Han-Yong; Jeon, Hwang Gyun

2016-08-09

Muscle-invasive bladder cancer (MIBC) consists of a heterogeneous group of tumors with a high rate of metastasis and mortality. To facilitate the in-depth investigation and validation of tailored strategies for MIBC treatment, we have developed an integrated approach using advanced high-throughput drug screening and a clinically relevant patient-derived preclinical platform. We isolated patient-derived tumor cells (PDCs) from a rare MIBC case (BD-138T) that harbors concomitant epidermal growth factor receptor (EGFR) amplification and phosphatase and tensin homolog (PTEN) deletion. High-throughput in vitro drug screening demonstrated that dasatinib, a SRC inhibitor, and PKI-587, a dual PI3K/mTOR inhibitor, exhibited targeted anti-proliferative and pro-apoptotic effects against BD-138T PDCs. Using established patient-derived xenograft models that successfully retain the genomic and molecular characteristics of the parental tumor, we confirmed that these anti-tumor responses occurred through the inhibition of SRC and PI3K/AKT/mTOR signaling pathways. Taken together, these experimental results demonstrate that dasatinib and PKI-587 might serve as promising anticancer drug candidates for treating MIBC with combined EGFR gene amplification and PTEN deletion.

SUBSTELLAR-MASS COMPANIONS TO THE K-GIANTS HD 240237, BD +48 738, AND HD 96127

International Nuclear Information System (INIS)

Gettel, S.; Wolszczan, A.; Niedzielski, A.; Nowak, G.; Adamów, M.; Zieliński, P.; Maciejewski, G.

2012-01-01

We present the discovery of substellar-mass companions to three giant stars by the ongoing Penn State-Toruń Planet Search conducted with the 9.2 m Hobby-Eberly Telescope. The most massive of the three stars, K2-giant HD 240237, has a 5.3 M J minimum mass companion orbiting the star at a 746 day period. The K0-giant BD +48 738 is orbited by a ≥0.91 M J planet which has a period of 393 days and shows a nonlinear, long-term radial velocity (RV) trend that indicates a presence of another, more distant companion, which may have a substellar mass or be a low-mass star. The K2-giant HD 96127 has a ≥4.0 M J mass companion in a 647 day orbit around the star. The two K2-giants exhibit a significant RV noise that complicates the detection of low-amplitude, periodic variations in the data. If the noise component of the observed RV variations is due to solar-type oscillations, we show, using all the published data for the substellar companions to giants, that its amplitude is anti-correlated with stellar metallicity.

Coal mining in the power industry of the Federal Republic of Germany in 2000; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2000

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-07-01

After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt.

Coal mining situation in the Federal Republic of Germany. 1st half of 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Halbjahr 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-09-01

The report on coal mining in Germany contains statistical data on the following issues: (a) Hard coal mining: part 1: production, resources, performance, employees; part 2: marketing and foreign commerce. (b) brown coal: part 1: production, resources, performance, employees; part II: marketing in domestic and foreign commerce.

Coal mining situation in the Federal Republic of Germany. 1st half of 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Halbjahr 2017

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-09-01

The report on coal mining in Germany contains statistical data on the following issues: (a) Hard coal mining: part 1: production, resources, performance, employees; part 2: sales and foreign trade. (b) brown coal: part 1: production, refinement, employees; part II: sales in domestic and foreign trade.

Coal mining situation in the Federal Republic of Germany. 1st half of 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Halbjahr 2015

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-08-28

The report on coal mining in Germany contains statistical data on the following issues: (a) Hard coal mining: part 1: production, resources, performance, employees; part 2: marketing and foreign commerce. (b) brown coal: part 1: production, resources, performance, employees; part II: marketing in domestic and foreign commerce.

Coal mining in the power industry of the Federal Republic of Germany in 2010; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2010

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-11-15

The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2010. Statistical data are presented for the power market and coal market, brown coal mining as well as the hard coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

Regulations in the Federal Republic of Germany. Exceptions to the law against competitive restrictions. Regulierung in der Bundesrepublik Deutschland. Die Ausnahmebereiche des Gesetzes gegen Wettbewerbsbeschraenkungen

Energy Technology Data Exchange (ETDEWEB)

Krakowski, M

1988-01-01

As a result of other countries' experiences, the Federal Republic has also been affected by the debate about regulation and deregulation. The discussion is centred particularly on exceptions to the law against competitive restrictions. This anthology aims to assist in clarifying the debate and gives a systematic account of the exceptions, including the theoretical justifications for regulation. Special weight is given to the description and explanation of the current status of regulation. The nature and scope of today's regulation can only be understood when its historical development is included in the examination. It is against this background that the authors make suggestions either for deregulation or for reformulation. The different chapters deal with: The theoretical basis of regulation, regulation in the areas of: The networked energy industry, telecommunications, traffic, banks, insurance markets. (orig./HSCH).

Coal mining situation in the Federal Republic of Germany. January to September 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2017

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-12-04

This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2017.

Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-06-06

The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

Data on the development of the West German power electric industry in 1984. Daten zur Entwicklung der Energiewirtschaft in der Bundesrepublik Deutschland im Jahre 1984

Energy Technology Data Exchange (ETDEWEB)

1985-07-01

An introductory survey of international and national energy policies in 1984 as well as of the energy supply situation in the Federal Republic of Germany is followed by statistics, tables and diagrams containing significant data of energy economics. In particular, they refer to the primary energy balance, structure of energy consumption, import and export of energy supplies and the development on the hard coal, brown coal, mineral oil, electricity and gas market (reserves, application, prices). The year under review, 1984, is related to and compared with previous years reaching back as far as 1970.

Coal mining in the power industry of the Federal Republic of Germany in 1998; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-11-01

After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. (orig.) [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt. (orig.)

Coal mining situation in the Federal Republic of Germany. January to September 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-11-16

This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2016.

Coal mining situation in the Federal Republic of Germany. January to September 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2015

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-11-30

This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2015.

Coal mining situation in the Federal Republic of Germany. January to September 2014; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-12-12

This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2014.

Coal mining in the power industry of the Federal Republic of Germany in 2016; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-11-15

The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2016. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

Coal mining situation in the Federal Republic of Germany. The 1st quarter 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2017

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-06-14

The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2017. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

Coal mining in the power industry of the Federal Republic of Germany in 2015; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2015

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-11-15

The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2015. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

Coal mining in the power industry of the Federal Republic of Germany in 2013; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2013

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-11-15

The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2013. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

Coal mining in the power industry of the Federal Republic of Germany in 2014; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2014

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-11-15

The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2014. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

Coal mining situation in the Federal Republic of Germany. The 1st quarter 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2015

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-07-07

The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2015. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

Regulations in the Federal Republic of Germany. Exceptions to the law against competitive restrictions. Regulierung in der Bundesrepublik Deutschland. Die Ausnahmebereiche des Gesetzes gegen Wettbewerbsbeschraenkungen

Energy Technology Data Exchange (ETDEWEB)

Krakowski, M.

1988-01-01

As a result of other countries' experiences, the Federal Republic has also been affected by the debate about regulation and deregulation. The discussion is centred particularly on exceptions to the law against competitive restrictions. This anthology aims to assist in clarifying the debate and gives a systematic account of the exceptions, including the theoretical justifications for regulation. Special weight is given to the description and explanation of the current status of regulation. The nature and scope of today's regulation can only be understood when its historical development is included in the examination. It is against this background that the authors make suggestions either for deregulation or for reformulation. The different chapters deal with: The theoretical basis of regulation, regulation in the areas of: The networked energy industry, telecommunications, traffic, banks, insurance markets. (orig./HSCH).

Evaluating the BD-100R [Bubble Technology Industries] as a neutron spectrometer through pressure variation

International Nuclear Information System (INIS)

White, B.; Ebert, D.; Munno, F.

1990-01-01

Other investigators have evaluated the dose response of neutron bubble dosimeters for possible use as personnel monitors for the U.S. Navy in low level radiation fields. In addition to dose measurements, these devices have been modified to measure the neutron energy spectra. These methods tend to be cumbersome, inaccurate, or both and do not use the same devices as employed in the dosimetry. The BD-100R dosimeter used in this work consists of a test tube containing an elastic polymer with interspersed droplets of two types of Freon; Freon-12 and Freon-114. Each superheated liquid droplet is a potential nucleation site. The minimum energy needed to form a bubble from the nucleation site is given by, E = 16πγ 3 (T)/3(ΔP) 2 , where ΔP is the difference between the vapor pressure of the droplet and the applied pressure. Upon reaching a critical radius, a bubble becomes unstable and grows in size. It may be seen from this equation that the energy deposition required for bubble formation is inversely proportional to the square of the pressure difference. The number of bubbles formed continually decreases with increasing applied pressure, until a pressure is reached where no bubbles are formed since the energy transferred can no longer vaporize the Freon. This investigation is intended to demonstrate the determination of an unknown spectrum utilizing the dosimeter response (number of bubbles formed) as a function of the neutron energy (applied pressure). A set of 12 dosimeters was initially exposed outside the East Beam Port (EBP) at the Maryland University Training Reactor (MUTR). The dosimeters were inside a pressure chamber which could accommodate up to 18 dosimeters. The same set of dosimeters were irradiated using a paraffin moderated PuBe source for which the neutron energy spectrum is unknown. There were eight exposures of six dosimeters at varied pressures in the EBP. The average number of bubbles and standard deviation was measured for each pressure. Data

Das Framework for Information Literacy. Neue Impulse für die Förderung von Informationskompetenz in Deutschland?!

Directory of Open Access Journals (Sweden)

Fabian Franke

2017-12-01

Full Text Available Das Framework for Information Literacy for Higher Education wurde im Januar 2016 vom Vorstand der Association of College & Research Libraries (ACRL beschlossen. Es beruht auf der Idee von „Threshold Concepts“ und sieht Informationskompetenz in einem engen Zusammenhang mit Wissenschaft und Forschung. Dadurch legt es bei der Vermittlung von Informationskompetenz eine starke Betonung auf das „Warum“, nicht nur auf das „Was“. Der Ansatz des Framework wird vielfach kontrovers diskutiert. Bietet er tatsächlich eine neue Sichtweise auf die Förderung von Informationskompetenz oder ist er überwiegend alter Wein in neuen Schläuchen? Kann das Framework neue Impulse für die Aktivitäten an den Bibliotheken in Deutschland setzen oder beschreibt es etwas, was wir längst machen? Der Beitrag versucht, Anregungen zu geben, welche Konsequenzen das Framework für unsere Kurse haben kann und welche veränderten Lernziele mit ihm verbunden sein können. Dabei plädiert er für ein umfassendes Verständnis von Informationskompetenz, das sich nicht auf Einzelaspekte wie Recherchekompetenz beschränkt. The Framework for Information Literacy for Higher Education was adopted by the Board of the Association of College & Research Libraries (ACRL in January 2017. It is based on the idea of threshold concepts and connects information literacy, research and scholarship. Therefore it focuses primarily on the “Why”, not only on the “What”. The approach of the Framework has often been controversially discussed. Does it actually provide a new perspective on the promotion of information literacy? Can the Framework provide new impetus for the activities of the German libraries, or does it describe something we are already doing? The paper tries to give suggestions how the framework may help to improve our courses. The author argues for a comprehensive understanding of information literacy, which is not limited to individual aspects such as research

Modularer studienbegleitender Deutschunterricht zur Vorbereitung auf Studium und Praktikum in Deutschland am Beispiel der German-Jordanian University in Amman, Jordanien

Directory of Open Access Journals (Sweden)

Michael de Jong

2015-04-01

Full Text Available Die German-Jordanian University (GJU ist eine staatliche Hochschule in Amman, Jordanien, die durch das Bundesministerium für Bildung und Forschung (BMBF und den Deutschen Akademischen Austauschdienst (DAAD gefördert wird. Gegründet im Jahr 2005, ist es noch eine sehr junge Universität. Ihr Alleinstellungsmerkmal ist das verpflichtende vierte Studienjahr in Deutschland, in dem jeder Studierende ein Semester an einer deutschen Partnerhochschule und ein weiteres in einem Praktikum verbringt. In den ersten drei Jahren ihres Studiums müssen alle Studieren­den sechs Stufen Deutsch in einem maßgeschneiderten Programm des German Language Centers absolvieren. Der vorliegende Artikel skizziert die Strukturen des Zentrums, beschreibt den modulbasierten Deutschunterricht und diskutiert die Herausforderungen eines der größten German Language Center weltweit.   The German-Jordanian University (GJU is a public institution of higher education located in Amman, Jordan, funded by the German Federal Ministry of Education and Research (BMBF and the German Academic Exchange Service (DAAD. Founded in 2005, it is still a very young university. Its unique selling proposition is the compulsory 4th year in Germany, during which every student spends one semester at a partner university and a second semester doing an internship. In the first three years of their studies, all students have to pass six levels of German in a tailor-made program provided by the German Language Center. This article outlines the structure of the center, describes the module-based German language tuition and discusses the challenges faced by one of the biggest German Language Centers in the world.

BD -22 5866: A Low-Mass, Quadruple-lined Spectroscopic and Eclipsing Binary

Science.gov (United States)

Shkolnik, Evgenya; Liu, Michael C.; Reid, I. Neill; Hebb, Leslie; Cameron, Andrew C.; Torres, Carlos A.; Wilson, David M.

2008-08-01

We report our discovery of an extremely rare, low-mass, quadruple-lined spectroscopic binary BD -22 5866 (=NLTT 53279, integrated spectral type = M0 V), found during an ongoing search for the youngest M dwarfs in the solar neighborhood. From the cross-correlation function, we are able to measure relative flux levels, estimate the spectral types of the components, and set upper limits on the orbital periods and separations. The resulting system is hierarchical, composed of a K7 + K7 binary and an M1 + M2 binary with semimajor axes of aAsin iA system was unresolved with published adaptive optics imaging, limits the projected physical separation of the two binaries at the time of the observation to dABlesssim 4.1 AU at the photometric distance of 51 pc. The maximum observed radial velocity difference between the A and B binaries limits the orbit to aABsin iAB systems, we speculate that an early dynamical process reduced the size of the system, such as the interaction of the two binaries with a circumquadruple disk. Intensive photometric, spectroscopic, and interferometric monitoring, as well as a parallax measurement of this rare quadruple system, is certainly warranted. Based on observations collected at the W. M. Keck Observatory and the Canada-France-Hawaii Telescope (CFHT). The Keck Observatory is operated as a scientific partnership between the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation. The CFHT is operated by the National Research Council of Canada, the Centre National de la Recherche Scientifique of France, and the University of Hawaii.

The 6-31B(d) basis set and the BMC-QCISD and BMC-CCSD multicoefficient correlation methods.

Science.gov (United States)

Lynch, Benjamin J; Zhao, Yan; Truhlar, Donald G

2005-03-03

Three new multicoefficient correlation methods (MCCMs) called BMC-QCISD, BMC-CCSD, and BMC-CCSD-C are optimized against 274 data that include atomization energies, electron affinities, ionization potentials, and reaction barrier heights. A new basis set called 6-31B(d) is developed and used as part of the new methods. BMC-QCISD has mean unsigned errors in calculating atomization energies per bond and barrier heights of 0.49 and 0.80 kcal/mol, respectively. BMC-CCSD has mean unsigned errors of 0.42 and 0.71 kcal/mol for the same two quantities. BMC-CCSD-C is an equally effective variant of BMC-CCSD that employs Cartesian rather than spherical harmonic basis sets. The mean unsigned error of BMC-CCSD or BMC-CCSD-C for atomization energies, barrier heights, ionization potentials, and electron affinities is 22% lower than G3SX(MP2) at an order of magnitude less cost for gradients for molecules with 9-13 atoms, and it scales better (N6 vs N,7 where N is the number of atoms) when the size of the molecule is increased.

BD+15 2940 AND HD 233604: TWO GIANTS WITH PLANETS CLOSE TO THE ENGULFMENT ZONE

International Nuclear Information System (INIS)

Nowak, G.; Niedzielski, A.; Adamów, M.; Maciejewski, G.; Wolszczan, A.

2013-01-01

We report the discovery of planetary-mass companions to two red giants by the ongoing Penn State-Toruń Planet Search (PTPS) conducted with the 9.2 m Hobby-Eberly Telescope. The 1.1 M ☉ K0-giant, BD+15 2940, has a 1.1 M J minimum mass companion orbiting the star at a 137.5 day period in a 0.54 AU orbit what makes it the closest—in planet around a giant and possible subject of engulfment as the consequence of stellar evolution. HD 233604, a 1.5 M ☉ K5-giant, is orbited by a 6.6 M J minimum mass planet which has a period of 192 days and a semi-major axis of only 0.75 AU making it one of the least distant planets to a giant star. The chemical composition analysis of HD 233604 reveals a relatively high 7 Li abundance which may be a sign of its early evolutionary stage or recent engulfment of another planet in the system. We also present independent detections of planetary-mass companions to HD 209458 and HD 88133, and stellar activity-induced radial velocity variations in HD 166435, as part of the discussion of the observing and data analysis methods used in the PTPS project.

Deep geothermal energy probe Heubach. Project plan and facility planning by using a practical example; Tiefen-Erdwaermesonde Heubach. Projektablauf und Anlagenplanung anhand eines Praxisbeispiels

Energy Technology Data Exchange (ETDEWEB)

Kuntz, David; Kuebert, Markus; Walker-Hertkorn, Simone [tewag GmbH, Starzach-Felldorf (Germany); Lemes, Zijad [HEAG Suedhessische Energie AG (HSE), Darmstadt (Germany). Q100 Regenerative Energien; Fritsche, Johann-Gerhard; Koett, Anne [Hessisches Landesamt fuer Umwelt und Geologie (HLUG), Wiesbaden (Germany)

2012-10-16

For the decentralized supply of an industrial company in Heubach nearby Gross-Umbach (Federal Republic of Germany) with geothermal energy for heating and cooling, the first geothermal deep drilling was performed in the German federal state of Hesse. The concept of a sustainable energy supply is based on the utilization of heat and cold from near-surface geothermal energy as well as on the heat production from an 800 metre coaxial deep geothermal probe (K-TEWS). HEAG Suedhessische Energie AG (Darmstadt, Bundesrepublik Deutschland) is the project manager. The company H. Anger's Soehne (Hessisch Lichtenau, Federal Republic of Germany) as a project partner is responsible for the execution of the drilling. Due to the innovative character and the outstanding importance for the future utilization of the geothermal energy for the energy supply, this project was promoted by the Hessian Ministry for the Environment, Energy, Agriculture and Consumer Protection (Wiesbaden, Federal Republic of Germany). The Hessian Agency for the Environment and Geology (Wiesbaden, Federal Republic of Germany) as well as the University Kassel (Kassel, Federal Republic of Germany) serve as scientific counterparts. Tewag GmbH (Regensburg, Federal Republic of Germany) is the technical planner of the geotechnical component of the execution of construction work, and is in charge of the thermal simulation and elaboration of the optimal extension concept. By means of this research and demonstration project, experiences on the heat supply using TEWS systems as well as on the project plan have to be acquired. Furthermore, experiences on the optimization in the planning and implementation are to be acquired in order to evaluate the transferability and economic efficiency at future locations practically. After presentation of the project, the authors of the contribution under consideration describe the planning phases of the project, some aspects of the public relations, the planning approaches, the

The Pedotopia Project: A Transdisciplinary Experiment in Soil Education

Science.gov (United States)

Toland, A.; Wessolek, G.

2012-04-01

as a platform for the production of new soil-oriented artworks. An exhibition of the resulting works as well as a symposium on the cultural values of soil conservation was held at the annual meeting of the German Soil Science Society (DBG) in 2011 in Berlin. In the following paper we will present the Pedotopia project as a case study in transdisciplinary soil education. We will highlight main points of the curriculum, present the results of the project and address challenges and future considerations of transdisciplinary soil education. SOURCES FELLER, LARDY and UGOLINI (2010): The Representation of Soil in the Western Art: From Genesis to Pedogenesis. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 3-21 SZLEZAK, E. (2009) "Soilart with the Colours of the Earth". In: Amt der NÖ LandesregierungAbteilung Landentwicklung. Stand 2009. http://www.soilart.eu/1-0-Home.htm (abgerufen am 20. Dezember 2011) TOLAND, A. & WESSOLEK, G. (2010): Merging Horizons - Soil Science and Soil Art. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 45-66 WAGNER, M. (2002): Erde als Material künstlerische Gestaltung. In: BUSCH, B. (2002) (Hrsg.): Erde. Schriftenreihe Forum, Bd. 11, Elemente des Naturhaushalts III. Kunst- und Ausstellungshalle der Bundesrepublik Deutschland GmbH, Köln, 246-260

A business case for on-site generation: The BD biosciences pharmingen project

Energy Technology Data Exchange (ETDEWEB)

Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

2003-09-01

Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

Ecology trends in Greece and in the Federal Republic of Germany. Oekologiebewegung in Griechenland und in der Bundesrepublik Deutschland; Unter Beruecksichtigung historischer, gesellschaftspolitischer und theoretischer Aspekte

Energy Technology Data Exchange (ETDEWEB)

Dede, I.

1993-01-01

This study evolves and discusses a thesis which maintains that ecology trends, both in Greece and in the Federal Republic of Germany, are the results of specific processes of social ''modernization'' based on different historical developments. A definition of ''modernization'' is given discussing the ''Fordism'' conception as part of the regulation theory: ''new'' social trends are interpreted as the results of the practice and crisis of Fordistic capitalism which, however, differs depending on its ''metropolitan'' (Germany) and ''peripheral'' (Greece) manifestations. The applicability of the Fordism theorem to Greece is discussed taking into account some political and cultural parameters. (orig.)

Die Zukunft der ärztlichen Weiterbildung in Deutschland – Positionspapier des Ausschusses Weiterbildung der Gesellschaft für Medizinische Ausbildung (GMA [The future of graduate medical education in Germany – Position paper of the committee on graduate medical education of the Society for Medical Education (GMA

Directory of Open Access Journals (Sweden)

Weih, Markus

2013-05-01

Full Text Available [english] The German graduate medical education system is going through an important phase of changes. Besides the ongoing reform of the national guidelines for graduate medical education (Musterweiterbildungsordnung, other factors like societal and demographic changes, health and research policy reforms also play a central role for the future and competitiveness of graduate medical education.With this position paper, the committee on graduate medical education of the Society for Medical Education (GMA would like to point out some central questions for this process and support the current discourse.As an interprofessional and interdisciplinary scientific society, the GMA has the resources to contribute in a meaningful way to an evidence-based and future-oriented graduate medical education strategy.In this position paper, we use four key questions with regards to educational goals, quality assurance, teaching competence and policy requirements to address the core issues for the future of graduate medical education in Germany. The GMA sees its task in contributing to the necessary reform processes as the only German speaking scientific society in the field of medical education.[german] Die ärztliche Weiterbildung in Deutschland befindet sich im Umbruch. Neben der aktuellen Reform der Musterweiterbildungsordnung spielen gesellschaftliche, demographische, gesundheits- und forschungspolitische Faktoren eine wichtige Rolle für die Zukunft und Konkurrenzfähigkeit der ärztlichen Weiterbildung.Der Ausschuss für Weiterbildung der Gesellschaft für Medizinische Ausbildung (GMA möchte mit diesem Positionspapier auf zentrale Fragen in diesem Prozess aufmerksam machen und Impulse für den aktuellen Diskurs geben.Dabei kann die GMA als interdisziplinäre und interprofessionelle Fachgesellschaft wichtige Beiträge zu einer evidenzbasierten und zukunftsorientierten Weiterbildungsstrategie liefern.Im vorliegenden Papier werden anhand von vier Leitfragen zu

Plutarque, Sur l' E de Delphes 390 B 6-8 et l'explication de  la vision en Timée 45 b-d*

Directory of Open Access Journals (Sweden)

Alain Lernould

2005-04-01

Full Text Available Le traité (ou dialogue « pythique » du platonicien Plutarque de Chéronée (Iier – IIe s. ap. J.-C. intitulé Sur l’E de Delphes est consacré à l’élucidation de la signification de l’E (la cinquième lettre de l’alphabet grec consacré à Apollon Pythien. Une des interprétations (d’inspiration pythagoricienne est que cet E désigne le nombre cinq, le nombre de l’univers. Dans le cadre de l’exposé de cette interprétation est fait état de l’opinion « de certains » selon laquelle il existe une correspondance entre les cinq sens et les cinq éléments. L’A. montre que les deux lignes où il est question de la vue (E 390b6-8 s’inspirent essentiellement de l’explication qu’en Timée 45b-d Platon donne du mécanisme de la vision en termes de mélange du feu pur émis par l’œil avec le feu pur extérieur qui produit la lumière du jour. L’extrême brièveté de ce résumé (empreint d’aristotélisme, l’élément associé à la vue étant ici l’éther considéré comme cinquième corps, d’un passage dans Platon offrant lui-même bon nombre de difficultés, explique que ces deux lignes énigmatiques n’aient jamais été bien comprises. Au passage, l’A. revient sur les notions d’homoiopatheia (d’homogénéité et de summetria (de commensurabilité en Timée 45b-d et 67c-e pour en proposer une interprétation qui souligne et éclaire d’un jour nouveau le caractère dynamique de l’explication platonicienne de la vision. Un Appendice donne un aperçu des différentes lectures d’E 390b6-8 depuis les premières éditions imprimées à la Renaissance jusqu’aux éditions critiques des 19e et 20e siècles.The essay (or dialogue On the E at Delphi of the Platonist Plutarch of Chaeronea (c. 50 – c. 125 A.D. is devoted to the elucidation of the mysterious E – the fifth letter of the Greek alphabet – that is dedicated to Apollo. According to one interpretation the E is, in a Pythagorean

Market success proves the efficiency of directives in the gas industry in the Federal Republic of Germany; Markterfolg belegt Effizienz des gaswirtschaftlichen Ordnungsrahmens in der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Weyand, M

1994-09-01

Deregulation is the catchword which has been ruling the present debate about energy-economy regulations in the Federal Republic of Germany. Deregulation can be interpreted at least in two ways: 1. Maintenance of existing regulations but modification of regulations which are part of the energy economy laws, 2. Introduction of a compulsory gas transit regulation for the benefit of third parties, compulsory deconcentration of the utilities, and abrogation or change of basic legal conditions. Both approaches are discussed and evaluated. (HW) [Deutsch] Die jetzige Diskussion ueber den energiewirtschaftlichen Ordnungsrahmen in der BRD ist durch das Schlagwort Deregulierung gepraegt. Hierfuer existieren jedoch mindestens zwei verschiedene Interpretationen: 1. Grundsaetzliche Beibehaltung des bestehenden Ordnungsrahmens bei gleichzeitiger Modifizierung von Regelungen im Energiewirtschaftsgesetz; 2. Einfuehrung einer Zwangsdurchleitung zugunsten Dritter, Zwangsentflechtung der Versorgungsunternehmen sowie Abschaffung bzw. Aenderung grundlegender ordnungsrechtlicher Rahmenbedingungen. Der vorliegende Beitrag versucht eine kritische Auseinandersetzung mit den beiden Ansaetzen. (HW)

The period analysis of V418 AQL, SU BOO, RV CVn, CR CAS, GV CYG, V432 PER, and BD+42 2782

International Nuclear Information System (INIS)

Zasche, P.; Wolf, M.; Kučáková, H.; Uhlař, R.

2014-01-01

The minimum timings of eclipsing binaries V418 Aql, SU Boo, RV CVn, CR Cas, GV Cyg, V432 Per, and BD+42 2782 were collected and analyzed. Their long-term behavior was studied via period analysis, revealing a periodic term in eclipse times. We derived 576 new times of minimum. Hence, to describe the periodic variation, a third-body hypothesis was proposed and the resulting orbital periods are as follows: 70, 7.4, 53, 37, 27, 53, and 18 yr, respectively. For the system V432 Per an additional 9.5 yr variation was also found. The predicted minimum masses of these distant bodies were calculated and their detectability discussed. The light curves of SU Boo and RV CVn were analyzed using the PHOEBE program, resulting in physical parameters of the components. New variable stars in the field of V418 Aql were discovered.

Particle Reduction Strategies - PAREST. Uncertainities of the PAREST reference emission data base. Sub-report; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Unsicherheiten der PAREST-Referenz-Emissionsdatenbasis. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Joerss, Wolfram; Handke, Volker [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

2013-06-15

In the research project PAREST1 emission scenarios to 2020 for particulate matter (PM10 and PM2, 5), and aerosol precursors SO{sub 2}, NO{sub x}, NH{sub 3} and NMVOC are created for Germany and Europe, mitigation measures evaluated and the resulting PM immission load for Germany are modeled. In this sub-report of PAREST the analysis of the uncertainties of the reference emission data base is presented for Germany. [German] Im Forschungsvorhaben PAREST1 wurden Emissionsszenarien bis 2020 fuer Feinstaub (PM10 und PM2,5) und die Aerosol-Vorlaeufersubstanzen SO{sub 2}, NO{sub x}, NH{sub 3} und NMVOC fuer Deutschland und Europa erstellt, Minderungsmassnahmen evaluiert und daraus die PM-Immissionsbelastung fuer Deutschland modelliert. In diesem Teilbericht zu PAREST wird die Analyse der Unsicherheiten der Referenz-Emissionsdatenbasis fuer Deutschland vorgestellt.

Marktkonstitution und Regulierung der unabhängigen Film- und Fernsehproduktion : Staat, Verbände und Gewerkschaften im deutsch-britischen Vergleich

OpenAIRE

Elbing, Sabine; Voelzkow, Helmut

2006-01-01

"In einem internationalen Vergleich von Deutschland und Großbritannien wird untersucht, welche Beiträge die staatliche Politik und die Wirtschafts- und Sozialpartner (Wirtschafts- und Arbeitgeberverbände sowie Gewerkschaften) zur Förderung der unabhängigen Film- und Fernsehproduktion leisten. Es wird gezeigt, dass die britische Medienpolitik die Position der unabhängigen Film- und Fernsehproduktion gegenüber den Fernsehsendern gestärkt hat. In Deutschland hat die Medienpolitik darauf verzicht...

TRUMP-BD: A computer code for the analysis of nuclear fuel assemblies under severe accident conditions

International Nuclear Information System (INIS)

Lombardo, N.J.; Marseille, T.J.; White, M.D.; Lowery, P.S.

1990-06-01

TRUMP-BD (Boil Down) is an extension of the TRUMP (Edwards 1972) computer program for the analysis of nuclear fuel assemblies under severe accident conditions. This extension allows prediction of the heat transfer rates, metal-water oxidation rates, fission product release rates, steam generation and consumption rates, and temperature distributions for nuclear fuel assemblies under core uncovery conditions. The heat transfer processes include conduction in solid structures, convection across fluid-solid boundaries, and radiation between interacting surfaces. Metal-water reaction kinetics are modeled with empirical relationships to predict the oxidation rates of steam-exposed Zircaloy and uranium metal. The metal-water oxidation models are parabolic in form with an Arrhenius temperature dependence. Uranium oxidation begins when fuel cladding failure occurs; Zircaloy oxidation occurs continuously at temperatures above 13000 degree F when metal and steam are available. From the metal-water reactions, the hydrogen generation rate, total hydrogen release, and temporal and spatial distribution of oxide formations are computed. Consumption of steam from the oxidation reactions and the effect of hydrogen on the coolant properties is modeled for independent coolant flow channels. Fission product release from exposed uranium metal Zircaloy-clad fuel is modeled using empirical time and temperature relationships that consider the release to be subject to oxidation and volitization/diffusion (''bake-out'') release mechanisms. Release of the volatile species of iodine (I), tellurium (Te), cesium (Ce), ruthenium (Ru), strontium (Sr), zirconium (Zr), cerium (Cr), and barium (Ba) from uranium metal fuel may be modeled

TRUMP-BD: A computer code for the analysis of nuclear fuel assemblies under severe accident conditions

Energy Technology Data Exchange (ETDEWEB)

Lombardo, N.J.; Marseille, T.J.; White, M.D.; Lowery, P.S.

1990-06-01

TRUMP-BD (Boil Down) is an extension of the TRUMP (Edwards 1972) computer program for the analysis of nuclear fuel assemblies under severe accident conditions. This extension allows prediction of the heat transfer rates, metal-water oxidation rates, fission product release rates, steam generation and consumption rates, and temperature distributions for nuclear fuel assemblies under core uncovery conditions. The heat transfer processes include conduction in solid structures, convection across fluid-solid boundaries, and radiation between interacting surfaces. Metal-water reaction kinetics are modeled with empirical relationships to predict the oxidation rates of steam-exposed Zircaloy and uranium metal. The metal-water oxidation models are parabolic in form with an Arrhenius temperature dependence. Uranium oxidation begins when fuel cladding failure occurs; Zircaloy oxidation occurs continuously at temperatures above 13000{degree}F when metal and steam are available. From the metal-water reactions, the hydrogen generation rate, total hydrogen release, and temporal and spatial distribution of oxide formations are computed. Consumption of steam from the oxidation reactions and the effect of hydrogen on the coolant properties is modeled for independent coolant flow channels. Fission product release from exposed uranium metal Zircaloy-clad fuel is modeled using empirical time and temperature relationships that consider the release to be subject to oxidation and volitization/diffusion ( bake-out'') release mechanisms. Release of the volatile species of iodine (I), tellurium (Te), cesium (Ce), ruthenium (Ru), strontium (Sr), zirconium (Zr), cerium (Cr), and barium (Ba) from uranium metal fuel may be modeled.

Rcupcake: an R package for querying and analyzing biomedical data through the BD2K PIC-SURE RESTful API.

Science.gov (United States)

Gutiérrez-Sacristán, Alba; Guedj, Romain; Korodi, Gabor; Stedman, Jason; Furlong, Laura I; Patel, Chirag J; Kohane, Isaac S; Avillach, Paul

2018-04-15

In the era of big data and precision medicine, the number of databases containing clinical, environmental, self-reported and biochemical variables is increasing exponentially. Enabling the experts to focus on their research questions rather than on computational data management, access and analysis is one of the most significant challenges nowadays. We present Rcupcake, an R package that contains a variety of functions for leveraging different databases through the BD2K PIC-SURE RESTful API and facilitating its query, analysis and interpretation. The package offers a variety of analysis and visualization tools, including the study of the phenotype co-occurrence and prevalence, according to multiple layers of data, such as phenome, exposome or genome. The package is implemented in R and is available under Mozilla v2 license from GitHub (https://github.com/hms-dbmi/Rcupcake). Two reproducible case studies are also available (https://github.com/hms-dbmi/Rcupcake-case-studies/blob/master/SSCcaseStudy_v01.ipynb, https://github.com/hms-dbmi/Rcupcake-case-studies/blob/master/NHANEScaseStudy_v01.ipynb). paul_avillach@hms.harvard.edu. Supplementary data are available at Bioinformatics online.

Resonance Raman studies of Escherichia coli cytochrome bd oxidase. Selective enhancement of the three heme chromophores of the "as-isolated" enzyme and characterization of the cyanide adduct.

Science.gov (United States)

Sun, J; Osborne, J P; Kahlow, M A; Kaysser, T M; Hil, J J; Gennis, R B; Loehr, T M

1995-09-26

Cytochrome bd oxidase is a terminal bacterial oxidase containing three cofactors: a low-spin heme (b558), a high-spin heme (b595), and a chlorin d. The center of dioxygen reduction has been proposed to be at a dinuclear b595/d site, whereas b558 is mainly involved in transferring electrons from ubiquinone. One of the unique functional features of this enzyme is its resistance to high concentrations of cyanide (Ki in the millimolar range). With the appropriate selection of laser lines, the ligation and spin states of the b558, b595, and d hemes can be probed selectively by resonance Raman (rR) spectroscopy. Wavelengths between 400 and 500 nm predominantly excite the rR spectra of the b558 and b595 chromophores. Spectra obtained within this interval show a mixed population of spin and ligation states arising from b558 and b595, with the former more strongly enhanced at higher energy. Red excitation wavelengths (590-650 nm) generate rR spectra characteristic of chlorins, indicating the selective enhancement of the d heme. These rR results reveal that cytochrome bd oxidase "as isolated" contains the b558 heme in a six-coordinate low-spin ferric state, the b595 heme in a five-coordinate high-spin (5cHS) ferric state, and the d heme in a mixture of oxygenated (FeIIO2 FeIIIO2-; d650) and ferryl-oxo (FeIV = O; d680) states. However, the rR spectra of these two chlorin species indicate that they are both in the 5cHS state, suggesting that the d heme is lacking a strongly coordinated sixth ligand.(ABSTRACT TRUNCATED AT 250 WORDS)

Detecting asymptomatic Trichomonas vaginalis in females using the BD ProbeTec™ Trichomonas vaginalis Qx nucleic acid amplification test.

Science.gov (United States)

Lord, Emily; Newnham, Tana; Dorrell, Lucy; Jesuthasan, Gerald; Clarke, Lorraine; Jeffery, Katie; Sherrard, Jackie

2017-03-01

Trichomonas vaginalis (TV) rates in women are increasing and many are asymptomatic. Nucleic acid amplification tests (NAATs) are becoming the 'gold standard' for diagnosis. We aimed to establish our asymptomatic TV rates by testing all women attending Oxfordshire's Sexual Health service, regardless of symptoms, using the BD ProbeTec™ TV Q x NAATs (BDQ x ). During BDQ x 's verification process, the sensitivity and specificity were calculated using results of 220 endocervical samples from symptomatic women, compared with culture. BDQ x was subsequently implemented and prospectively evaluated over 6 months in female attendees. Wet mount microscopy was also performed in symptomatics. Demographic and clinical characteristics of those diagnosed were analysed. From 220 samples tested by BDQ x and culture: 5 were positive on both and one solely using BDQ x , giving a sensitivity and specificity of 100% and 99.53%, respectively. In the prospective cohort, of 5775 BDQ x tests, 33 (0.57%) were positive. 11/33 (33%) patients were asymptomatic. All patients diagnosed had risk factors: age >25 years (85%), residence in a deprived area (79%) and black ethnicity (21%). Despite BDQ x being highly sensitive and specific, with our low TV prevalence universal screening may not be justified. Targeted screening using local demographic data merits further investigation.

Hoffen auf den guten Willen – von der unverbindlichen Institutionalisierung feministischer Forderungen

Directory of Open Access Journals (Sweden)

Maike Bußmann

2008-11-01

Full Text Available Nachdem die Protagonistinnen der ersten Frauenbewegung prinzipiell den Zugang in die Institutionen erstritten hatten, wurde seit den 1968ern der Marsch durch die Institutionen angetreten. Diesen untersucht Stefanie Ehmsen für die Vereinigten Staaten und die Bundesrepublik, wobei sie die Unterschiede als Resultat der jeweiligen politischen Traditionen interpretiert. Zwar wartet sie mit gut recherchierten und lesenswerten Fallbeispielen auf, doch das Potential der Analyse wird leider nicht ausgeschöpft.

Bürgerengagement und Protestpolitik. Das politische Wirken des „Remstalrebellen“ Helmut Palmer und die Reaktionen seiner Mitmenschen

OpenAIRE

Knauer, Jan

2011-01-01

Die Dissertation untersucht politische Kommunikation, Protestpolitik und Bürgerengagement in der Bundesrepublik anhand des politischen Einzelkämpfers Helmut Palmer (1930-2004), des „Remstalrebellen“. Helmut Palmer zählt zu den bemerkenswertesten Persönlichkeiten in der Geschichte des Bundeslandes Baden-Württemberg. Mit seinem Wirken als Protestpolitiker ohne Unterstützung durch eine Organisation oder Partei prägte er seit den 1960er Jahren in ca. 300 Bürgermeister-, Landtags- und Bundestagswa...

Particle Reduction Strategies - PAREST. PM10-cause analysis based on hypothetical emissions scenarios. Sub-report; Strategien zur Verminderung der Feinstaubbelastung - PAREST. PM10-Ursachenanalyse auf der Basis hypothetischer Emissionsszenarien. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

2013-06-15

In this report, a PM10 cause analysis is presented, which provides an estimation of the extent to which the emitted substances from ten different source sectors are responsible for the calculated PM10 concentrations in Germany (PM = particulate matter). [German] In diesem Bericht wird eine PM10-Ursachenanalyse vorgestellt, die eine Abschaetzung liefert, in welchem Umfang die in Deutschland von den verschiedenen Verursachergruppen emittierten Stoffe fuer die in Deutschland berechneten PM10-Konzentrationen verantwortlich sind.

Land has power. Energy transition an opportunity for rural areas. Documentation; Land unter Strom. Die Energiewende als Chance fuer den laendlichen Raum. Dokumentation

Energy Technology Data Exchange (ETDEWEB)

Bredenbeck, Martin; Gotzmann, Inge (comps.)

2015-07-01

The energy transition affects the rural areas of Germany in particular. Which Opportunities and risks this brings there shows a new release of Bund Heimat und Umwelt in Deutschland (German heritage and Environmental Foundation (BHU)). The Federation of heritage and civic associations devoted to the question of how to the conventional expansion of renewable energies innovative options can added. Thereby a diversified positioning of energy use, the advancement of historical forms of use and the spatial differentiation are important factors. [German] Die Energiewende betrifft die laendlichen Raeume Deutschlands in besonderem Masse. Welche Chancen und Risiken sie dort bringt, zeigt eine Neuerscheinung des Bund Heimat und Umwelt in Deutschland (BHU). Der Bundesverband der Heimatverbaende, Heimat- und Buergervereine widmet sich der Frage, wie zum konventionellen Ausbau erneuerbarer Energien innovative Optionen hinzutreten koennen. Eine breite Aufstellung von Energienutzungen, die Weiterentwicklung historischer Nutzungsformen und die raeumliche Differenzierung sind dabei wichtige Faktoren.

LOOKING FOR A CONNECTION BETWEEN THE Am PHENOMENON AND HYBRID {delta} Sct -{gamma} Dor PULSATION: DETERMINATION OF THE FUNDAMENTAL PARAMETERS AND ABUNDANCES OF HD 114839 AND BD +18 4914

Energy Technology Data Exchange (ETDEWEB)

Hareter, M.; Weiss, W. [Department of Astronomy, University of Vienna, Tuerkenschanzstrasse 17, A-1180 Wien (Austria); Fossati, L. [Department of Physics and Astronomy, Open University, Walton Hall, Milton Keynes MK6 7AA (United Kingdom); Suarez, J. C. [Instituto de Astrofisica de Andalucia (CSIC), Glorieta de la Astronomia S/N, 18008, Granada (Spain); Uytterhoeven, K. [Kiepenheuer-Institut fuer Sonnenphysik, Schoeneckstr. 6, D-79104 Freiburg (Germany); Rainer, M.; Poretti, E., E-mail: hareter@astro.univie.ac.at [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, 23807, Merate (Saint Lucia) (Italy)

2011-12-20

{delta} Sct-{gamma} Dor hybrids pulsate simultaneously in p- and g-modes, which carry information on the structure of the envelope as well as to the core. Hence, they are key objects for investigating A and F type stars with asteroseismic techniques. An important requirement for seismic modeling is small errors in temperature, gravity, and chemical composition. Furthermore, we want to investigate the existence of an abundance indicator typical for hybrids, something that is well established for the roAp stars. Previous to the present investigation, the abundance pattern of only one hybrid and another hybrid candidate has been published. We obtained high-resolution spectra of HD 114839 and BD +18 4914 using the SOPHIE spectrograph of the Observatoire de Haute-Provence and the HARPS spectrograph at ESO La Silla. For each star we determined fundamental parameters and photospheric abundances of 16 chemical elements by comparing synthetic spectra with the observations. We compare our results to that of seven {delta} Sct and nine {gamma} Dor stars. For the evolved BD +18 4914 we found an abundance pattern typical for an Am star, but could not confirm this peculiarity for the less evolved star HD 114839, which is classified in the literature as uncertain Am star. Our result supports the concept of evolved Am stars being unstable. With our investigation we nearly doubled the number of spectroscopically analyzed {delta} Sct-{gamma} Dor hybrid stars, but did not yet succeed in identifying a spectroscopic signature for this group of pulsating stars. A statistically significant spectroscopic investigation of {delta} Sct- {gamma} Dor hybrid stars is still missing, but would be rewarding considering the asteroseismological potential of this group.

LOOKING FOR A CONNECTION BETWEEN THE Am PHENOMENON AND HYBRID δ Sct -γ Dor PULSATION: DETERMINATION OF THE FUNDAMENTAL PARAMETERS AND ABUNDANCES OF HD 114839 AND BD +18 4914

International Nuclear Information System (INIS)

Hareter, M.; Weiss, W.; Fossati, L.; Suárez, J. C.; Uytterhoeven, K.; Rainer, M.; Poretti, E.

2011-01-01

δ Sct-γ Dor hybrids pulsate simultaneously in p- and g-modes, which carry information on the structure of the envelope as well as to the core. Hence, they are key objects for investigating A and F type stars with asteroseismic techniques. An important requirement for seismic modeling is small errors in temperature, gravity, and chemical composition. Furthermore, we want to investigate the existence of an abundance indicator typical for hybrids, something that is well established for the roAp stars. Previous to the present investigation, the abundance pattern of only one hybrid and another hybrid candidate has been published. We obtained high-resolution spectra of HD 114839 and BD +18 4914 using the SOPHIE spectrograph of the Observatoire de Haute-Provence and the HARPS spectrograph at ESO La Silla. For each star we determined fundamental parameters and photospheric abundances of 16 chemical elements by comparing synthetic spectra with the observations. We compare our results to that of seven δ Sct and nine γ Dor stars. For the evolved BD +18 4914 we found an abundance pattern typical for an Am star, but could not confirm this peculiarity for the less evolved star HD 114839, which is classified in the literature as uncertain Am star. Our result supports the concept of evolved Am stars being unstable. With our investigation we nearly doubled the number of spectroscopically analyzed δ Sct-γ Dor hybrid stars, but did not yet succeed in identifying a spectroscopic signature for this group of pulsating stars. A statistically significant spectroscopic investigation of δ Sct- γ Dor hybrid stars is still missing, but would be rewarding considering the asteroseismological potential of this group.

Social costs of energy consumption. External effects of electricity consumption in the Federal Republic of Germany. Soziale Kosten des Energieverbrauchs. Externe Effekte des Elektrizitaetsverbrauchs in der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Hohmeyer, O

1988-01-01

This study provides a first systematic quantification and conversion into monetary terms of the relevant social costs and benefits, in order to create a basis for corrective measures with respect to the use of wind power and the photovoltaic use of solar energy. Four main areas of social costs of energy systems are looked at in the study: Environmental costs, including the effect on human health. Inadequate consideration of the long-term shortage of resources in present-day market prices. Macroeconomic effects such as changes in the net product or employment. Subsidies via state agencies, which are made partly in the form of direct payments and partly in an indirect way in the form of state services. State subsidies in the area of research and development can be subsumed under the last point. In each of these main fields there is a multiplicity of separate external effects which are dealt with at length in a special chapter. (orig./UA) With 20 figs., 24 tabs.

Power consumption in detail of private households in the Federal Republic of Germany 1997 - 2000. Study; Detaillierung des Stromverbrauchs privater Haushalte in der Bundesrepublik Deutschland 1997 - 2010. Studie

Energy Technology Data Exchange (ETDEWEB)

Boede, U.; Bradke, H.; Cremer, C.

2000-12-01

The study includes all electric appliances except for those used to heat rooms. 53 of these power-consuming appliances were also examined in detail as to their idle-power consumption (consumption during stand-by and apparent non-activity). The investigations covered specific performance, the typical sort of use and the development of the stocks. 1997 was used as the basic year. The development is estimated for the years 2000, 2005 and 2010. To identify the stand-by losses, the operational states were defined accurately. This makes it possible to determine which loss is caused by which operational mode. [German] Die Studie beruecksichtigt alle Elektrogeraete ausser solche fuer Raumwaerme. 53 dieser stromverbrauchenden Geraete wurden darueber hinaus bezueglich ihres Leerlaufverbrauchs (Verbrauch im Bereitschaftsbetrieb und im Schein-Aus-Zustand) detailliert betrachtet. Untersucht wurden die spezifische Leistungsaufnahme, die typische Anwendung und die Bestandsentwicklung. Als Basisjahr wurde 1997 herangezogen. Die Entwicklung wird abgeschaetzt fuer die Jahre 2000, 2005 und 2010. Zur Identifizierung der Leerlaufverluste wurde eine genaue Definition der Betriebszustaende vorgenommen. Dadurch ist es moeglich zuzuordnen, welcher Verlust auf welchen Betriebsmodus entfaellt. (orig.)

Dezentrale vs. zentrale Wärmeversorgung im deutschen Wärmemarkt: Vergleichende Studie aus energetischer und ökonomischer Sicht

OpenAIRE

Pfnür, Andreas; Winiewska, Bernadetta; Mailach, Bettina; Oschatz, Bert

2016-01-01

[Einführung] Mit dem Energiekonzept hat die Bundesregierung eine relativ klare Vorgabe für die zukünftige Energieversorgung in Deutschland gemacht. Sie soll umweltschonend, zuverlässig und bezahlbar sein. Entsprechend dem Energiekonzept sollen bis 2020 die Treibhausemissionen in Deutschland um 40 % und bis 2050 um mindestens 80 % - jeweils gegenüber 1990 - reduziert werden. Der Primärenergieverbrauch soll bis 2020 um 20 % und bis 2050 um 50 % - jeweils gegenüber 2008 - sinken. Weiterhin soll ...

Evaluation of the BD BACTEC FX blood volume monitoring system as a continuous quality improvement measure.

Science.gov (United States)

Coorevits, L; Van den Abeele, A-M

2015-07-01

The yield of blood cultures is proportional to the volume of blood cultured. We evaluated an automatic blood volume monitoring system, recently developed by Becton Dickinson within its BACTEC EpiCenter module, that calculates mean volumes of negative aerobic bottles and generates boxplots and histograms. First, we evaluated the filling degree of 339 aerobic glass blood cultures by calculating the weight-based volume for each bottle. A substantial amount of the bottles (48.3%) were inadequately filled. Evaluation of the accuracy of the monitoring system showed a mean bias of -1.4 mL (-15.4%). Additional evaluation, using the amended software on 287 aerobic blood culture bottles, resulted in an acceptable mean deviation of -0.3 mL (-3.3%). The new software version was also tested on 200 of the recently introduced plastic bottles, which will replace the glass bottles in the near future, showing a mean deviation of +2.8 mL (+26.7%). In conclusion, the mean calculated volumes can be used for the training of a single phlebotomist. However, filling problems appear to be masked when using them for phlebotomist groups or on wards. Here, visual interpretation of boxplots and histograms can serve as a useful tool to observe the spread of the filling degrees and to develop a continuous improvement program. Re-adjustment of the software has proven to be necessary for use with plastic bottles. Due to our findings, BD has developed further adjustments to the software for validated use with plastic bottles, which will be released soon.

Guide to the construction of small-scale hydropower plants; 2. ed.; Leitfaden fuer den Bau von Kleinwasserkraftanlagen

Energy Technology Data Exchange (ETDEWEB)

Berg, W.; Giesecke, J.; Grabitz, R.; Haakh, F.; Haury, H.G.; Horlacher, H.B.; Hutarew, A.; Latrille, W.; Mackert, W.; Mueller, P.; Sauer, K.; Schmid, H.; Schweickert, H.; Waller, H.

1994-12-31

einzelnen Kapitel sind aus Fachbeitraegen der Mitglieder des eingangs erwaehnten Autorenkollektivs hervorgegangen und beruecksichtigen im wesentlichen die Verhaeltnisse in der Bundesrepublik Deutschland (Baden-Wuerttemberg). Sie erweitern damit das in Kapitel 3 erstmals in deutscher Sprache wiedergegebene Handbuch der Internationalen Elektrotechnischen Kommission, das weltweit gueltig sein und sich deshalb auf Technik und Ablauforganisation beschraenken muss. Bewusst ist ein Lehrbuchcharakter zugunsten der konkreten, praxisnahen Darstellung des Problemkreises zurueckgetreten. Der Wasserwirtschaftsverband und die Autoren hoffen auch, durch diesen Leitfaden in der Oeffentlichkeit das Interesse fuer den weiteren energiepolitisch, privatwirtschaftlich und oekologisch ausgewogenen Ausbau von Kleinwasserkraeften geweckt zu haben. (orig.)

Un Woyzeck sui fronti del Novecento. «Eiche und Angora» di Martin Walser

Directory of Open Access Journals (Sweden)

Maurizio Pirro

2014-10-01

Full Text Available Martin Walser’s play Eiche und Angora (1962 deals with the persistence of totalitarianism-oriented mental structures after the Second World War and the collapse of the Nazi regime. Walser represents political history as strongly opposed to the private sphere of ordinary people. Adjustment to the post-war situation of the Bundesrepublik and continuity with the historical past are seen by Walser as equivalent forms of self-defense against the inhuman attitude of political power.

[Delayed testing for the diagnosis of fungi in the urines. Evaluation of the BD Vacutainer C&S tubes for the storage of urine samples at room temperature].

Science.gov (United States)

Baixench, M T; Al-Sheikh, M; Paugam, A

2005-01-01

The study included 37 urine samples which have been artificially infected with low levels (10(3) CFU/mL) of various fungi strains. We compared the effects of sample storage, up to 48 hours, at room temperature, in a urine evacuated tube containing specific additives with storage at + 4 degrees C, for the same length of time, in a urine evacuated tube without any additives. There have been no differences of results (speed of growth and colony size) between the 2 modes of storage. However, the experience has shown that samples needed a careful mixing before seeding to avoid underdetection of the strains. Based on the study results, the BD Vacutainer C&S tubes are suitable for delayed testing for the diagnosis of urine fungal infection.

Hairy root induction and phytoremediation of textile dye, Reactive green 19A-HE4BD, in a halophyte, Sesuvium portulacastrum (L. L.

Directory of Open Access Journals (Sweden)

Vinayak H. Lokhande

2015-12-01

Full Text Available In this study, we report phytoremediation of textile dyes using hairy roots derived through Agrobacterium rhizogenes (NCIM 5140 infection of in vitro leaf and stem explants of a halophyte Sesuvium portulacastrum (L. L. Leaf explants showed higher frequency of hairy root induction (70% than stem explants (30%, and maximum number of roots (leaf 42.3 ± 2.4 and stem 50.3 ± 1.7. Transformed nature of hairy roots was ascertained by amplifying 970 bp region of T-DNA of Ri plasmid. Hairy roots were screened for phytoremediation of various textile dyes and results showed that HRs were able to degrade Reactive green 19A HE4BD upto 98% within 5 days of incubation. Spectrophotometric analysis showed decrease in dye concentration while HPLC and FTIR analysis confirmed its degradation. Seed germination assay demonstrated non-toxic nature of the extracted metabolites. This is the first report on induction of hairy root culture in Sesuvium portulacastrum and phytoremediation of textile dyes.

The Design and Production of the LHCb VELO High Voltage System and Analysis of the Bd ⇒ K*μ+μ- Rare Decay

CERN Document Server

Rakotomiaramanana, Barinjaka Mamitiana; Soler, P

2010-01-01

LHCb is the dedicated flavour physics experiment of the LHC. The experiment is designed for probing new physics through measurements of CP violation and rare decays. This thesis includes simulation studies of the Bd ⇒ K*μ+μ- decay. The LHCb vertex locator (VELO) is the highest precision tracking detector at the LHC and is used to identify primary and secondary vertices for the identification of the $b$ and $c$ hadrons. The VELO modules contain silicon strip detectors which must be operated under reverse bias voltage. This thesis presents the work performed on the design, production and characterisation of the VELO high voltage system. The VELO operates only 8\\mm~from the LHC beam in a high radiation environment. A future upgrade will require operation at up to 10$^{16}$ n_{eq}cm^{-2}.This thesis presents a characterisation of p-type silicon sensors before and after heavy irradiations. The design of the HV system and the substantial programme of quality assurance tests performed on both the hardware and so...

Does recent mania affect response to antidepressants in bipolar disorder? A re-analysis of STEP-BD data.

Science.gov (United States)

Mousavi, Zahra; Johnson, Sheri; Li, Descartes

2018-08-15

One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression. 320 participants were available for analyses (140 male) diagnosed with bipolar I, bipolar II, cyclothymia, bipolar disorder not otherwise specified, or schizoaffective disorder bipolar subtype. Patients were randomly assigned to 3 treatment randomization strata (placebo, bupropion, and paroxetine) as adjuncts to mood stabilizers. Analyses were conducted to examine the effect of episode status before the depressive episode on the degree of change in depressive symptoms at 3 and 6 months, the likelihood of depression recovery and the likelihood of anti-depressant induced switching. Presence of a manic episode before depression in patients with bipolar disorder did not significantly predict response to antidepressants. The study was limited by a high rate of attrition, and consideration of only two antidepressant medications. Our findings are in agreement with other past studies suggesting that mania and depression may operate separately for those with bipolar disorder, with differential predictors of the onset and offset of mania versus depression. Future directions may consider vulnerability for these episodes separately. Copyright © 2018 Elsevier B.V. All rights reserved.

Use of an automated blood culture system (BD BACTEC™) for diagnosis of prosthetic joint infections: easy and fast.

Science.gov (United States)

Minassian, Angela M; Newnham, Robert; Kalimeris, Elizabeth; Bejon, Philip; Atkins, Bridget L; Bowler, Ian C J W

2014-05-04

For the diagnosis of prosthetic joint infection (PJI) automated BACTEC™ blood culture bottle methods have comparable sensitivity, specificity and a shorter time to positivity than traditional cooked meat enrichment broth methods. We evaluate the culture incubation period required to maximise sensitivity and specificity of microbiological diagnosis, and the ability of BACTEC™ to detect slow growing Propionibacteria spp. Multiple periprosthetic tissue samples taken by a standardised method from 332 patients undergoing prosthetic joint revision arthroplasty were cultured for 14 days, using a BD BACTEC™ instrumented blood culture system, in a prospective study from 1st January to 31st August 2012. The "gold standard" definition for PJI was the presence of at least one histological criterion, the presence of a sinus tract or purulence around the device. Cases where > =2 samples yielded indistinguishable isolates were considered culture-positive. 1000 BACTEC™ bottle cultures which were negative after 14 days incubation were sub-cultured for Propionibacteria spp. 79 patients fulfilled the definition for PJI, and 66 of these were culture-positive. All but 1 of these 66 culture-positive cases of PJI were detected within 3 days of incubation. Only one additional (clinically-insignificant) Propionibacterium spp. was identified on terminal subculture of 1000 bottles. Prolonged microbiological culture for 2 weeks is unnecessary when using BACTEC™ culture methods. The majority of clinically significant organisms grow within 3 days, and Propionibacteria spp. are identified without the need for terminal subculture. These findings should facilitate earlier decisions on final antimicrobial prescribing.

Wie lässt sich die günstigste Schlepperstärke für die Vollmechanisierung des bäuerlichen Familienbetriebes bestimmen?

OpenAIRE

Hartel, Erhard

2018-01-01

Die Durchschnittsgrösse aller Betriebe zwischen 5 und 20 ha liegt in der Bundesrepublik bei 9, 7 ha. Da ein grosser Teil davon, besonders die Betriebe zwischen 5 - 8 ha, zu klein sind, um ein genügendes Einkommen für die Besitzerfamilie abzuwerfen, sollen diese Betriebe durch Aufstockung saniert werden. Die Betriebsgrösse, die unter mittleren Ertragsbedingungen als genügende Existenzgrundlage angesehen wird, liegt zwischen 10 und 15 ha. Damit kommen wir zu einer Durchschnittsgrösse für den Fa...

A guide for implementation of the European Pollutant Emission Register (EPER) in Germany; Leitfaden zur Umsetzung des Europaeischen Schadstoffemissionsregisters (EPER) in Deutschland

Energy Technology Data Exchange (ETDEWEB)

Kuehne, C.; Striegel, G.

2001-10-01

The report presents specifications for implementing the European Pollutant Emission Register (EPER) in Germany. [German] Gemaess Artikel 15 (3) der Richtlinie 96/61/EG ueber die integrierte Vermeidung und Verminderung der Umweltverschmutzung ('IVU-Richtlinie') veroeffentlicht die Kommission alle drei Jahre ein Verzeichnis der wichtigsten Emissionen und ihrer Quellen anhand der von den Mitgliedstaaten uebermittelten Informationen. Fuer die Mitgliedstaaten ergibt sich hieraus die Verpflichtung, die erforderlichen Daten zu erheben, auszuwerten und der Europaeischen Kommission zu berichten. In der Entscheidung der Kommission vom 17. Juli 2000 ueber den Aufbau eines Europaeischen Schadstoffemissionsregisters (EPER- 'European Pollutant Emission Register') 2000/479/EG ('EPER-Entscheidung') werden die Anforderungen an Inhalt und Form dieses Verzeichnisses konkretisiert: - Die Mitgliedstaaten berichten der Kommission ueber die Emissionen in die Luft und in das Wasser aus einzelnen Betriebseinrichtungen. Zu berichten sind die Emissionen bestimmter Schadstoffe, die ueber vorgegebenen Schwellenwerten liegen. Das Berichtsformat fuer die Mitgliedstaaten ist im Anhang A2 der EPER-Entscheidung festgelegt. - Der erste Bericht ist im Juni 2003 vorzulegen und soll Angaben ueber Emissionen im Jahr 2001 (bzw. wahlweise 2000 oder 2002) enthalten. Jeder Mitgliedstaat muss zudem einen zusammenfassenden nationalen Uebersichtsbericht erstellen. - Die Europaeische Kommission wird die Emissionsdaten ueber das Internet der Oeffentlichkeit zugaenglich machen. Fuer die Erhebung der fuer das EPER erforderlichen Daten in Deutschland wird ein schrittweises Vorgehen empfohlen: - Am Anfang steht die Identifizierung von Betriebseinrichtungen mit Taetigkeiten nach Anhang I der IVU-Richtlinie. - Angabe des NACE-Kodes der Betriebseinrichtung und Zuordnung der Anhang I-Taetigkeiten (Quellenkategorie) und des NOSE-P-Kodes gemaess Anhang A3 der EPER-Entscheidung. - Festlegung

Highly Enantioselective Production of Chiral Secondary Alcohols Using Lactobacillus paracasei BD101 as a New Whole Cell Biocatalyst and Evaluation of Their Antimicrobial Effects.

Science.gov (United States)

Yılmaz, Durmuşhan; Şahin, Engin; Dertli, Enes

2017-11-01

Chiral secondary alcohols are valuable intermediates for many important enantiopure pharmaceuticals and biologically active molecules. In this work, we studied asymmetric reduction of aromatic ketones to produce the corresponding chiral secondary alcohols using lactic acid bacteria (LAB) as new biocatalysts. Seven LAB strains were screened for their ability to reduce acetophenones to their corresponding alcohols. Among these strains, Lactobacillus paracasei BD101 was found to be the most successful at reducing the ketones to the corresponding alcohols. The reaction conditions were further systematically optimized for this strain and high enantioselectivity (99%) and very good yields were obtained. These secondary alcohols were further tested for their antimicrobial activities against important pathogens and significant levels of antimicrobial activities were observed although these activities were altered depending on the secondary alcohols as well as their enantiomeric properties. The current methodology demonstrates a promising and alternative green approach for the synthesis of chiral secondary alcohols of biological importance in a cheap, mild, and environmentally useful process. © 2017 Wiley-VHCA AG, Zurich, Switzerland.

Protection of the climate in Germany. Second report presented by the Government of the Federal Republic of Germany according to the United Nations Agreement on Climatic Changes; Klimaschutz in Deutschland. Zweiter Bericht der Regierung der Bundesrepublik Deutschland nach dem Rahmenuebereinkommen der Vereinten Nationen ueber Klimaaenderungen

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-11-01

This report is the second government report after the climate convention. It contains an inventory of emissions of relevance for the greenhouse effect and the states where they are stored (forest) plus a description of the government`s preventive measures to protect the climate. You can find emission scenarios and the projection to the years 2000, 2005, 2010 and 2020 and an assessment of the effects of the measures. (orig./SR)

Technology assessment explained by the example of peaceful uses of nuclear energy in the Federal Republic of Germany. Technologiefolgenabschaetzung am Beispiel der friedlichen Nutzung der Kernenergie in der Bundesrepublik Deutschland

Energy Technology Data Exchange (ETDEWEB)

Mueller-Brandeck, G

1986-01-01

The study reviews technology assessment (TA), i.e. the instrument, and the way it has been used and is currently used in the F.R.G., for solving problems induced by technologies. The first part of the study presents the historical background and evolution of nuclear energy policy and discusses the rationality of large-scale technological innovation. The second part deals with the assessment of the nuclear technology, explaining aspects such as social acceptance, the institutional network established for TA, and the 'experiment of parallel research: TA between the two poles of producing an alibi, or creating consensus, assessment of the waste disposal sector, social compatibility, research into problems affecting public acceptance. In conclusion, the study goes into related aspects in connection with nuclear technology assessments, and the social learning process that has set in. (HSCH).

Legal bases of resource policy in the Federal Republic of Germany. A contribution towards law-related geography. Die rechtlichen Grundlagen der Ressourcenpolitik in der Bundesrepublik Deutschland. Ein Beitrag zur Rechtsgeographie

Energy Technology Data Exchange (ETDEWEB)

Graafen, R

1983-01-01

This work from the field of law-related geography deals with the legal regulations issued in the framework of resource policy and with their territorial effects. One of the purpose of law-related geography is to present those legal regulations which bear on territory in a manner easy to survey. The different legal forms to be considered (law, legal regulation, administrative regulation, statutes, law of the (European Community etc.) provide a means of approach. From the peculiarities of the individual legal forms it is possible to tell for instance in how far they possess validity as against citizens or only as against authorities, in how far they are cogent or only constitute recommendations, or whether citizens are allowed to participate in the precise definition of regulations, what standard of European Community law are immediately applied in the Federal Republic of Germany, or what the order of priority of legal regulations is. The study investigates above all the territory-related consequences of regional and land use planning, the federal mining law, energy policy with regard to black coal, brown coal, petroleum and naturel gas, of the planning of power plans sites, local supply concepts, transport infra-structure policy, the federal immission protection law and of regulations for the protection of nature or governing forest and water management. (orig./HSCH).

Landeskundeunterricht zum Nationalsozialismus. Ein Praxisbericht aus der Mongolei

Directory of Open Access Journals (Sweden)

Ralf Heimrath

2015-03-01

Full Text Available In einer Umfrage bei den fortgeschrittenen Studierenden an der Deutschen Abteilung der Nationaluniversität der Mo n- golei wurde festgestellt, dass der Name Hitler sehr bekannt und mit e iner positiven Konnotation verbunden ist. Dagegen gab es keine Kenntnisse über die Zeit des Nationalsozialismus in Deutschland. Mehrere weitere Beobachtungen lassen darüber hinaus in der Mongolei und in anderen Ländern eine bestimmte Hitler - Verehrung erken nen. Vor diesem Hintergrund wurde im Jahr 2012 an der Deutschen Abteilung der Nationaluniversität der Mongolei eine Unterricht s- sequenz zum Thema Nationalsozialismus in Deutschland durchgeführt. Die wichtigsten Themen sind dabei die Persönlichkeit des Dikt ators, der Werdegang der NSDAP während der Weimarer Republik und das Schicksal der jüdischen Bevölkerung in Deutschland vor und insbesondere nach der Machtergreifung Hitlers. Die Sequenz dient der Relativierung des Hitler - Bildes im Bewusstsein der Studiere nden und der Vermittlung von Kenntnissen zur Geschichte des 20. Jahrhunderts als Grundlage einer Entwicklung, die zu zwei deutschen Staaten und ihrer späteren Vereinigung führte. Die Sequenz ist auf vergleichbare Unterrichtssituationen in anderen Ländern übertragbar.

1. expert congress on geothermal power: On the way to a new energy future. Proceedings; 1. Fachkongress Geothermischer Strom: Start in eine neue Energiezukunft. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Tagungsband befasst sich mit den folgenden Themen: 1. Allgemeiner Teil: a) Die Rolle der Geothermie im Rahmen einer zukunftsfaehigen Energieversorgung; b) Effiziente Foerderinstrumente fuer Erneuerbare Energien; c) Geothermische Ressourcen fuer die Stromerzeugung (TAB-Studie); d) Vom Potenzial zur Nutzung - Konzepte fuer die geothermische Stromerzeugung in Deutschland; e) Eine energiewirtschaftliche Einordnung der Geothermie in das Energiesystem der Bundesrepublik Deutschland. Vergleich der unterschiedlichen Techniken, des Entwicklungsstandes, Marktpotenzials geothermischer Stromerzeugung und der bisher gemachten Erfahrungen in den laufenden Projekten. 2. Lokalbezug und Poster: a) Erkundung, Aufschluss, Bau und Betrieb der geothermischen Anlage in Neustadt-Glewe; b) Technisches Konzept des geothermischen Kraftwerks Neustadt-Glewe. 3. Exploration, Bohrtechnik: a) Abschaetzung der Erfolgswahrscheinlichkeit bei geothermischen Bohrungen; b) Seismische Exploration, Reservoirmodellierung und Reservoirsimulation zum Geothermieprojekt; c) Bohrtechnik und Bohrkosten fuer Sedimentgesteine. Bohren im Kristallin. 3. Komplettierung, Frac-Technik: a) Frac-Technik im Kristallin; b) Frac-Technik in Sedimenten; c) New-Technology MWD and LWD Systems Designed for Ultra-Deepwater and Geothermal Drilling; d) Weiterentwicklung geothermischer Stromerzeugung im sueddeutschen Kristallin. 4. Verstromung Geothermischer Energie: a) Effizienz der geothermischen Stromerzeugung; b) Duales Heizwerk gespeist mit einem geothermalen Wasser einer mittleren Enthalpie; c) Das Geothermiefeld der Insel Milos in Griechenland: Aktuelle geothermische Exploration und Entwicklung. 5. Poster der Tagung: a) Der UGGW - das innovative Konzept zur Standort unabhaengigen Stromerzeugung; b) Geothermische Ressourcen Russlands und Nutzungsprognose bis 2020; c) Auf der Lernkurve zum Geothermischen Strom: Das In situ Geothermielabor Gross Schoenebeck; d) Waermebegleitende Tiefbohrzemente: Zusammensetzungen, Untersuchungsmethode

Ethik, Recht und Theologie. Reproduktionstechnologien in Polen

Directory of Open Access Journals (Sweden)

Susanne Lettow

2006-03-01

Full Text Available Die bisherigen Debatten um Stammzellforschung, Klonen und Reproduktionstechnologien wurden in Deutschland weitgehend im nationalstaatlichen Rahmen und mit Blick auf Entwicklungen im angelsächsischen Raum geführt. Dabei sind diese Forschungsrichtungen und Technologien kein genuin „westliches“ Phänomen – immerhin wurde das erste Retortenkind in Polen bereits 1987 geboren. Heidi Hofmann lässt in ihrem Band polnische Philosoph/-innen, Jurist/-innen und Politikerinnen zu Wort kommen und öffnet den Blick dafür, dass die Art und Weise, in der Reproduktionstechnologien gesellschaftlich problematisiert werden, in Polen durch ganz andere politische, kulturelle und historische Konstellationen geprägt ist als in Deutschland.

Particle reduction strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. PM10- and PM2.5-reduction potentials by package of measures for further immission reduction in Germany. Sub-report.; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. PM10- und PM2,5-Minderungspotenziale von Massnahmenpaketen zur weiteren Reduzierung der Immissionen in Deutschland. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

2013-06-15

This report documents the effects of additional emission control measures the PM10 and PM2.5 air quality in Germany (PM = particulate matter). The immission effects of the planned measures were calculated with the Chemistry-Aerosol-Transport Model REM CALGRID (RCG). [German] Dieser Bericht dokumentiert die Auswirkungen zusaetzlicher emissionsmindernder Massnahmen auf die PM10 und PM2.5-Luftqualitaet in Deutschland. Die immissionsseitigen Auswirkungen der geplanten Massnahmen wurden auf der Basis von Berechnungen mit dem Chemie-Aerosol-Transportmodell REM-CALGRID (RCG) bestimmt. Grundlage der Szenarienrechnungen sind die im Rahmen des F and E-Vorhabens entwickelten Emissionsabschaetzungen, die die Aenderung der Emissionen aufgrund von technischen oder nicht-technischen Massnahmen beschreiben. Die den Berechnungen zugrunde liegende horizontale Aufloesung betraegt 0.125 Laenge und 0.0625 Breite oder circa 7 km x 8 km. Das meteorologische Referenzjahr ist 2005.

Genetic evidence for a high diversity and wide distribution of endemic strains of the pathogenic chytrid fungus Batrachochytrium dendrobatidis in wild Asian amphibians.

Science.gov (United States)

Bataille, Arnaud; Fong, Jonathan J; Cha, Moonsuk; Wogan, Guinevere O U; Baek, Hae Jun; Lee, Hang; Min, Mi-Sook; Waldman, Bruce

2013-08-01

Population declines and extinctions of amphibians have been attributed to the chytrid fungus Batrachochytrium dendrobatidis (Bd), especially one globally emerging recombinant lineage ('Bd-GPL'). We used PCR assays that target the ribosomal internal transcribed spacer region (ITS) of Bd to determine the prevalence and genetic diversity of Bd in South Korea, where Bd is widely distributed but is not known to cause morbidity or mortality in wild populations. We isolated Korean Bd strains from native amphibians with low infection loads and compared them to known worldwide Bd strains using 19 polymorphic SNP and microsatellite loci. Bd prevalence ranged between 12.5 and 48.0%, in 11 of 17 native Korean species, and 24.7% in the introduced bullfrog Lithobates catesbeianus. Based on ITS sequence variation, 47 of the 50 identified Korean haplotypes formed a group closely associated with a native Brazilian Bd lineage, separated from the Bd-GPL lineage. However, multilocus genotyping of three Korean Bd isolates revealed strong divergence from both Bd-GPL and the native Brazilian Bd lineages. Thus, the ITS region resolves genotypes that diverge from Bd-GPL but otherwise generates ambiguous phylogenies. Our results point to the presence of highly diversified endemic strains of Bd across Asian amphibian species. The rarity of Bd-GPL-associated haplotypes suggests that either this lineage was introduced into Korea only recently or Bd-GPL has been outcompeted by native Bd strains. Our results highlight the need to consider possible complex interactions among native Bd lineages, Bd-GPL and their associated amphibian hosts when assessing the spread and impact of Bd-GPL on worldwide amphibian populations. © 2013 John Wiley & Sons Ltd.

Renewables in figures. National and international trends in 2016; Erneuerbare Energien in Zahlen. Nationale und internationale Entwicklung im Jahr 2016

Energy Technology Data Exchange (ETDEWEB)

NONE

2017-09-15

The expansion of renewable energies is a central pillar of the energy transition. The development is positive: In 2016, renewable energies accounted for 31.7 percent of total gross electricity consumption. The brochure informs about the progress achieved in the further development of renewable energies in Germany, Europe and the world. The data on the development of renewable energies in Germany is based on the results of the Working Group on Renewable Energy Statistics (AGEE-Stat), which compiles the balance sheet of renewable energies for Germany on behalf of the BMWi. The data published here are a snapshot with the editorial deadline of August 2016 - they are still provisional in some places, especially for 2016. At the same time, current time series on the development of renewable energies in Germany since 1990 as well as a variety of graphs are published on the websites of the BMWi. These time series and graphs will be updated at the turn of the year 2017/2018. [German] Der Ausbau der erneuerbaren Energien ist eine zentrale Saeule der Energiewende. Die Entwicklung ist positiv: Im Jahr 2016 hatten die erneuerbare Energien einen Anteil von 31,7 Prozent am gesamten Bruttostromverbrauch. Mit der Broschuere wird ueber den erreichten Fortschritt beim weiteren Ausbau der Erneuerbaren Energien in Deutschland, in Europa und der Welt informiert. Grundlage der Daten zur Entwicklung der erneuerbaren Energien in Deutschland sind die Ergebnisse der Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des BMWi die Bilanz der erneuerbaren Energien fuer Deutschland erarbeitet. Die hier veroeffentlichten Daten stellen eine Momentaufnahme mit Redaktionsschluss August 2016 dar - sie haben insbesondere fuer das Jahr 2016 an einigen Stellen noch vorlaeufigen Charakter. Parallel werden auf den Internetseiten des BMWi aktuelle Zeitreihen zur Entwicklung der erneuerbaren Energien in Deutschland seit dem Jahr 1990 sowie vielfaeltige Schaubilder veroeffentlicht

Database for 'Environment 2000' environment presentation for EXPO 2000. Appendix 1 and 2: experimental data; Informationsgrundlage fuer das Umweltpraesentationssystem des BMU 'Umwelt 2000 im Rahmen des Teilvorhabens 2 des Globalansatzes Expo 2000'. Mit Anhang 1 und 2: 1. Katalog zur konsistenten Vorgehensweise bei der Erfassung von Rahmeninformationen in der Datenbank Grunddaten. 2. Datengrundlage fuer Umwelt Deutschland

Energy Technology Data Exchange (ETDEWEB)

Schoen, M.; Hillenbrand, T.; Kuntze, U.; Nathani, C.; Toussaint, D.; Behnke, L.; Michi, S.; Rauscher, J.; Ziesing, H.J.; Knoerr, W.; Tochtermann, K.; Dombeck, T.; Kadric, L.

2002-03-01

Goal of the study was to create a documentary system containing the relevant information available in the Federal Republic of Germany in order to provide a wide-scale presentation of the environmental situation. The theme catalogue which has been extended and modified in the course of the research work contains about 150 items. In order to obtain trend statements, a period of at least 10 years - between 1990 and 2000 - had to be evaluated. Since most of the available empirical time series do not go beyond 1998, projections based here on allowing a foresight on the medium-term developments in the subsequent two years or more were required. In two selected theme fields, scenarios until the year 2020 had to be developed: scenarios of emissions of greenhouse gases and precursors of greenhouse gases as well as for traffic development and environmental pollution caused by traffic. The basis for the documentary administration is the data bank 'DB Grunddaten' ('basic data'). This data bank was developed by the Federal Environmental Agency and had to be completed for the presentation system environment Germany. (orig.) [German] Fuer eine flaechendeckende Gesamtdarstellung des Umweltzustandes in Deutschland sollten die auf Bundesebene verfuegbaren Informationsbausteine in einem Dokumentationssystem bereitgestellt werden. Der im Lauf der Bearbeitung erweiterte und modifizierte Themenkatalog umfasste ca. 150 Positionen. Die Ordnung dieses Themenkataloges ist an den Pressure-State-Response-Ansatz angelehnt. Zur Ermoeglichung von Trendaussagen sollte dort, wo moeglich und sinnvoll, ein Darstellungszeitraum von mindestens zehn Jahren von 1990 bis 2000 gewaehlt werden. Da die verfuegbaren empirischen Zeitreihen meist nicht weiter als bis zum Jahr 1998 reichten, waren darauf aufbauende Projektionen der mittelfristigen Entwicklung ueber einen Zeitraum von zwei Jahren oder mehr erforderlich. In zwei ausgewaehlten Themenbereichen waren auch ueber das Jahr 2000

Agraareliidist Baltikumis 19. sajandil : ülevaade uurimiseisust / Tiit Rosenberg

Index Scriptorium Estoniae

Rosenberg, Tiit, 1946-

2013-01-01

Ettekanne konverentsil "Bauern und Adel im Prozess der Modernisierung Agrarische Elitern om Ostelbischen Deutschland, Nordosteuropa im 19. Jahrhundert" Marburgis J. G. Herderi Instituudis 16. 07. 1999

Comorbid obsessive-compulsive disorder with bipolar disorder: A distinct form?

Science.gov (United States)

Ozdemiroglu, Filiz; Sevincok, Levent; Sen, Gulnur; Mersin, Sanem; Kocabas, Oktay; Karakus, Kadir; Vahapoglu, Fatih

2015-12-30

We examined whether the patients with Bipolar Disorder (BD) and Obsessive-Compulsive Disorder (OCD) comorbidity may represent a distinct form of BD. The subjects diagnosed with BD (n=48), OCD (n=61), and BD with OCD (n=32) were compared in terms of several socio-demographic and clinical characteristics. Previous history of suicidal attempts was more likely to be higher in BD-OCD group compared to the other two groups. A more episodic course of OCD, higher rates of rapid cycling, and the seasonality were found in BD-OCD patients. The frequency of bipolar II and NOS subtypes was more prevalent in patients with BD-OCD than in OCD patients. The first diagnosed illness was BD in the majority of BD-OCD cases. It was found that first affective episode was major depression in half of BD-OCD patients. Age at onset of BD was found to be earlier in BD-OCD group compared to pure BD patients. Bipolarity may not have a specific effect on the phenomenology of OC symptoms. The episodic course of OCD, seasonality, rapid cycling, earlier onset of BD, and impulsivity in BD-OCD patients may be indicative for a distinct form of BD. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Vorgehensmodelle in Deutschland

DEFF Research Database (Denmark)

Kuhrmann, Marco; Linssen, Oliver

2015-01-01

sich die Anwendung von Vorgehensmodellen über die Zeit entwickelt hat. Die Studie hat gezeigt, dass eine Vielzahl von Vorgehensmodellen im Einsatz ist. Obwohl ein Trend weg von großen Standards zu beobachten ist, werden sowohl agile wie auch klassische Ansätze angewendet. Die Studie zeigt auch, dass...

The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology.

Science.gov (United States)

Wong, Rebecca; Levi, Angelique W; Harigopal, Malini; Schofield, Kevin; Chhieng, David C

2012-02-01

Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles. To determine the combined impact of the FocalPoint Guided Screener (GS) Imaging System (BD Diagnostics-TriPath, Burlington, North Carolina) and lean manufacturing principles on the turnaround time (TAT) and productivity of the gynecologic cytology operation. We established a baseline measure of the TAT for Papanicolaou tests. We then compared that to the performance after implementing the FocalPoint GS Imaging System and lean principles. The latter included value-stream mapping, workflow modification, and a first in-first out policy. The mean (SD) TAT for Papanicolaou tests before and after the implementation of FocalPoint GS Imaging System and lean principles was 4.38 (1.28) days and 3.20 (1.32) days, respectively. This represented a 27% improvement in the average TAT, which was statistically significant (P implementation of FocalPoint GS Imaging System in conjunction with lean principles resulted in a significant decrease in the average TAT for Papanicolaou tests and a substantial increase in the productivity of cytotechnologists while maintaining the diagnostic quality of gynecologic cytology.

Interdisciplinary analysis of the chances of implementation of an energy conservation and air pollution abatement policy. Adverse and favourable conditions for rational energy use in private households and their responsible decision-makers from an economic and social psychological perspective; Interdisziplinaere Analyse der Umsetzungschancen einer Energiespar- und Klimaschutzpolitik. Hemmende und foerdernde Bedingungen der rationellen Energienutzung fuer private Haushalte und ihr Akteursumfeld aus oekonomischer und sozialpsychologischer Perspektive

Energy Technology Data Exchange (ETDEWEB)

Hennicke, P.; Jochem, E.; Prose, F.

1997-08-01

The investigation attempted an analysis of the causes and remedies of the gap between ecological and climate-relevant requirements on the one hand and public and political action on the other hand. It presents a theoretical concept for an ecologically oriented social restructuring process which will support rational energy use and the appropriate research and development measures more strongly than it does now. While the Federal government intends a 25 % reduction of carbon dioxide emissions by 2005, an 80 % reduction is required on a long-term basis (e.g. by 2050). In view of this, the contribution of the German government is interpreted as a necessary but still insufficient contribution to sustainability. [German] Diese Studie erarbeitet einen Beitrag zur Analyse der Ursachen und Loesungsmoeglichkeiten fuer den Widerspruch zwischen umwelt- und klimarelevanten Handlungsnotwendigkeiten einerseits und den gesellschaftlichen Handlungsdefiziten andererseits. Weitergehend erbringt sie einen theoretisch-konzeptionellen Ansatz zum oekologischen Umbau der Industriegesellschaft. Dadurch wird konkret dazu beigetragen, die Politik zur rationellen Energieanwendung einschliesslich der Forschungs- und Entwicklungspolitik besser als bisher zu unterstuetzen. Ausgegangen wird von dem energie- und klimapolitischen Ziel der Bundesregierung, bis zum Jahr 2005 die CO{sub 2}-Emissionen gegenueber dem Referenzjahr 1990 um 25% zu reduzieren. Langfristig, bis etwa zum Jahr 2050, ist nach der Empfehlung der Klima-Enquete-Kommission eine CO{sub 2}-Reduktion um 80% erforderlich. Dieser Beitrag der Bundesrepublik zum internationalen Klimaschutz kann als notwendige, wenn auch noch nicht hinreichende Voraussetzung fuer eine 'zukunftsfaehige Entwicklung' (sustainability) in der Bundesrepublik interpretiert werden. (orig.)

Particle Reduction Strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. NO{sub 2}- and O{sub 3} reduction potentials of package of measures for further reduction of immissions in Germany; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. NO{sub 2}- und O{sub 3}-Minderungspotenziale von Massnahmenpaketen zur weiteren Reduzierung der Immissionen in Deutschland. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

2013-06-15

This report documents the effects of additional emission control measures the NO{sub 2}- and ozone-air quality in Germany (PM = particulate matter). The immission effects of the planned measures were calculated with the Chemistry-Aerosol-Transport Model REM CALGRID (RCG). [German] Dieser Bericht dokumentiert die Auswirkungen zusaetzlicher emissionsmindernder Massnahmen auf die NO{sub 2}- und die Ozon-Luftqualitaet in Deutschland. Die immissionsseitigen Auswirkungen der geplanten Massnahmen wurden auf der Basis von Berechnungen mit dem Chemie- Aerosol-Transportmodell REM-CALGRID (RCG) bestimmt. Grundlage der Szenarienrechnungen sind die im Rahmen des F and E-Vorhabens entwickelten Emissionsabschaetzungen, die die Aenderung der Emissionen aufgrund von technischen oder nicht-technischen Massnahmen beschreiben. Die den Berechnungen zugrunde liegende horizontale Aufloesung betraegt 0.125 Laenge und 0.0625 Breite oder circa 7 km x 8 km. Das meteorologische Referenzjahr ist 2005.

Brain Death in Pediatric Patients in Japan: Diagnosis and Unresolved Issues.

Science.gov (United States)

Araki, Takashi; Yokota, Hiroyuki; Fuse, Akira

2016-01-01

Brain death (BD) is a physiological state defined as complete and irreversible loss of brain function. Organ transplantation from a patient with BD is controversial in Japan because there are two classifications of BD: legal BD in which the organs can be donated and general BD in which the organs cannot be donated. The significance of BD in the terminal phase remains in the realm of scientific debate. As indicated by the increasing number of organ transplants from brain-dead donors, certain clinical diagnosis for determining BD in adults is becoming established. However, regardless of whether or not organ transplantation is involved, there are many unresolved issues regarding BD in children. Here, we will discuss the historical background of BD determination in children, pediatric emergencies and BD, and unresolved issues related to pediatric BD.

Optical Photometry and X-Ray Monitoring of the ``Cool Algol'' BD +05°706: Determination of the Physical Properties

Science.gov (United States)

Torres, Guillermo; Mader, Jeff A.; Marschall, Laurence A.; Neuhäuser, Ralph; Duffy, Alaine S.

2003-06-01

We present new photometric observations in the BVRI bands of the double-lined eclipsing binary BD +05°706 conducted over three observing seasons, as well as new X-ray observations obtained with ROSAT covering a full orbital cycle (P=18.9 days). A detailed light-curve analysis of the optical data shows the system to be semidetached, confirming indications from an earlier analysis by Torres et al. (published in 1998), with the less massive and cooler star filling its Roche lobe. The system is a member of the rare class of cool Algol systems, which are different from the ``classical'' Algol systems in that the mass-gaining component is also a late-type star rather than a B- or A-type star. By combining the new photometry with a reanalysis of the spectroscopic observations reported by Torres et al., we derive accurate absolute masses for the components of M1=2.633+/-0.028 Msolar and M2=0.5412+/-0.0093 Msolar, radii of R1=7.55+/-0.20 Rsolar and R2=11.02+/-0.21 Rsolar, as well as effective temperatures of 5000+/-100 and 4640+/-150 K, for the primary and secondary, respectively. There are obvious signs of activity (spottedness) in the optical light curve of the binary. Our X-ray light curve clearly shows the primary eclipse but not the secondary eclipse, suggesting that the primary star is the dominant source of the activity in the system. The depth and duration of the eclipse allow us to infer some of the properties of the X-ray-emitting region around that star.

Temporal sequencing of nicotine dependence and bipolar disorder in the national epidemiologic survey on alcohol and related conditions (NESARC)

Science.gov (United States)

Martínez-Ortega, José M.; Goldstein, Benjamin I.; Gutiérrez-Rojas, Luis; Sala, Regina; Wang, Shuai; Blanco, Carlos

2013-01-01

Bipolar disorder (BD) and nicotine dependence (ND) often co-occur. However, the mechanisms underlying this association remain unclear. We aimed to examine, for the first time in a national and representative sample, the magnitude and direction of the temporal relationship between BD and ND; and to compare, among individuals with lifetime ND and BD, the sociodemographic and clinical characteristics of individuals whose onset of ND preceded the onset of BD (ND-prior) with those whose onset of ND followed the onset of BD (BD-prior). The sample included individuals with lifetime BD type I or ND (n=7958) from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, n=43093). Survival analyses and logistic regression models were computed to study the temporal association between ND and BD, and to compare ND-prior (n=135) and BD-prior (n=386) individuals. We found that ND predicted the onset of BD and BD also predicted the onset of ND. Furthermore, the risk of developing one disorder following the other one was greatest early in the course of illness. Most individuals with lifetime ND and BD were BD-prior (72.6%). BD-prior individuals had an earlier onset of BD and a higher number of manic episodes. By contrast, ND-prior individuals had an earlier onset of both daily smoking and ND, and an increased prevalence of alcohol use disorder. In conclusion, ND and BD predict the development of each other. The phenomenology and course of ND and BD varied significantly depending on which disorder had earlier onset. PMID:23582710

The influence of social support on psychological distress in Canadian adults with bipolar disorder.

Science.gov (United States)

Warren, Christie D; Fowler, Ken; Speed, David; Walsh, Anna

2018-05-08

Individuals with bipolar I disorder (BD-I) and bipolar II disorder (BD-II) are at higher risk for experiencing high levels of psychological distress and low levels of social support. The primary objectives of this study were to examine perceived social support and psychological distress among Canadian adults with self-reported BD-I or BD-II as diagnosed by a health professional and explore the relationship between types of social support and psychological distress within this sample. Using a cross-sectional, national datafile, 563 Canadian male and female adults (20-64 years) who reported being diagnosed with BD-I or BD-II were investigated using the Social Provisions Scale (SPS), and the Kessler Psychological Distress Scale (K10). It was observed that while the BD-I or BD-II sample had significantly lower SPS scores and significantly higher K10 scores than the overall Canadian sample, age and support in the form of reassurance of worth and social integration were associated with decreased psychological distress. Further, a diagnosis of BD-I and BD-II was found to moderate the effect of social support on psychological distress. Despite the limitations, which include self-reported diagnosis of BD-I and BD-II and potential exclusion of those who are not diagnosed but have BD-I or BD-II, these findings suggest that reassurance of worth and social integration may act as protective factors for psychological distress among individuals with BD-I or BD-II.

[Detection of Staphylococcus aureus resistant to methicillin (MRSA) by molecular biology (Cepheid GeneXpert IL, GeneOhm BD, Roche LightCycler, Hyplex Evigene I2A) versus screening by culture: Economic and practical strategy for the laboratory].

Science.gov (United States)

Laudat, P; Demondion, E; Jouannet, C; Charron, J; Chillou, C; Salaun, V; Mankikian, B

2012-06-01

Patients admitted in cardiac surgery and cardiac ICU at the Clinic Saint-Gatien (Tours) are screened for MRSA at the entrance by nasal swab and culture on blood agar and selective chromogenic medium made by addition of cefoxitin: BBL CHROMagar MRSA-II BD (result obtained at Day +1). We wanted to assess the molecular biology techniques available to obtain a result at day 0 for the majority of patients and to define an economic and practical strategy for the laboratory. We studied four molecular biology techniques: Cepheid GeneXpert (Cepheid) GeneOhm (BD), LightCycler (Roche) and Hyplex (I2A). Upon reception, nasal swabs were treated by culture, considered as reference, and one of the techniques of molecular biology, according to the manufacturer's notice. We conducted four studies between April 2008 and February 2009 to obtain a significant sample for each of them. By screening we mean a method that allows us to exclude MRSA carriage for patients waiting for surgery, and not to change patient management: for example, lack of isolation measures specific to entrance, no modification of antibiotic prophylaxis during surgery and no isolation measures in the immediate postoperative period. The criteria we considered for this evaluation were: (1) technician time: time to perform one or a series of sample(s) n=10 or more (about 2h for all techniques except GeneXpert 75min), level of skilled competences (no specific training for GeneXpert); (2) results: turnaround time (all molecular biology techniques), ease of reading and results interpretations (no specialized training required for GeneXpert), failure or not (12% of failure of internal controls for GeneOhm); (3) economic: cost for one or a series of sample(s) (n=10 or more), if we considered X as the reference culture cost (10 X Hyplex and LightCycler, 20 X and 40 X for GeneXpert GeneOhm); (4) NPV: 100% for GeneXpert and LightCycler. At same sensitivity, no technique, including culture, can solve alone our problem, which

Spatiotemporal pattern of bacillary dysentery in China from 1990 to 2009: what is the driver behind?

Directory of Open Access Journals (Sweden)

Zhiwei Xu

Full Text Available Little is known about the spatiotemporal pattern of bacillary dysentery (BD in China. This study assessed the geographic distribution and seasonality of BD in China over the past two decades.Data on monthly BD cases in 31 provinces of China from January 1990 to December 2009 obtained from Chinese Center for Disease Control and Prevention, and data on demographic and geographic factors, as well as climatic factors, were compiled. The spatial distributions of BD in the four periods across different provinces were mapped, and heat maps were created to present the seasonality of BD by geography. A cosinor function combined with Poisson regression was used to quantify the seasonal parameters of BD, and a regression analysis was conducted to identify the potential drivers of morbidity and seasonality of BD.Although most regions of China have experienced considerable declines in BD morbidity over the past two decades, Beijing and Ningxia still had high BD morbidity in 2009. BD morbidity decreased more slowly in North-west China than other regions. BD in China mainly peaked from July to September, with heterogeneity in peak time between regions. Relative humidity was associated with BD morbidity and peak time, and latitude was the major predictor of BD amplitude.The transmission of BD was heterogeneous in China. Improved sanitation and hygiene in North-west China, and better access to clean water and food in the big floating population in some metropolises could be the focus of future preventive interventions against BD. BD control efforts should put more emphasis on those dry areas in summer.

Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.

Science.gov (United States)

Rivera, César; Monsalve, Francisco; Salas, Juan; Morán, Andrea; Suazo, Iván

2013-12-01

Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of treatment with either platelet-rich plasma (PRP) or plasma rich in growth factors (PRGF) in combination with SIMV in the regeneration and repair of alveolar bone. The jaws of Sprague Dawley rats (n=18) were subjected to rotary instrument-induced bone damage (BD). Animals were divided into six groups: BD/H 2 O (n=3), distilled water without the drug and alveolar bone damage; BD/H 2 O/PRP (n=3), BD and PRP; BD/H 2 O/PRGF (n=3), BD and PRGF; BD/SIMV (n=3), BD and water with SIMV; BD/SIMV/PRP (n=3), BD, PRP and SIMV; and BD/SIMV/PRGF (n=3), BD, PRGF and SIMV. Conventional histological analysis (hematoxylin and eosin staining) revealed that the BD/SIMV group showed indicators for mature bone tissue, while the BD/SIMV/PRP and BD/SIMV/PRGF groups showed the coexistence of indicators for mature and immature bone tissue, with no statistical differences between the platelet preparations. Simvastatin did not improve the effect of platelet-rich plasma and plasma rich in growth factors. It was not possible to determine which platelet preparation produced superior effects.

Dictionary of modern engineering. Vol. 1 and Vol. 2. Woerterbuch der modernen Technik. Bd. 1 und Bd. 2. Bd. 1: Englisch - Deutsch. Bd. 2: Deutsch - Englisch

Energy Technology Data Exchange (ETDEWEB)

Oppermann, A

1982-01-01

This work represents the most recent status of modern developments and indicates the complexity of man's technical future. The Dictionary of Modern Engineering contains more than 450,000 terms with over 1 million translation possibilities for the fields of aviation (civilian and military), space travel, navigation, engine, turbine and rocket construction, aerodynamics, statics, atomic physics, electronics, data processing, cybernetics, machine and tool construction, mineral oils, artificial materials, plasma, lasers, as well as all related fields. In addition, expressions in the field of air travel and its related subjects, newly developed under the auspices of BVM and ICAO, were included.

Integration of renewable energies into the power supply system; Integration erneuerbarer Energien in das Stromversorgungssystem

Energy Technology Data Exchange (ETDEWEB)

Neubarth, Juergen [e3 consult, Innsbruck (Austria)

2011-08-15

In contrast to the record breaking speed with which the German government presented its new energy concept in response to the Fukushima reactor disaster, the practical task of transforming our energy supply system will take decades. One of the greatest challenges involved in the energy turnaround will be that of integrating renewable energies into the power supply system. A holistic analysis and assessment of all aspects involved in this is therefore of utmost importance. Under the focal topic of its new publication ''Energie fuer Deutschland 2011'', Weltenergierat Deutschland e.V. presents a detailed summary of this challenge, thus providing a basis for further discussion. It shows that efficient integration of renewable energies must necessarily involve a combination of systems engineering and organisational measures.

Radiation therapy of benign diseases: patterns of care study in Germany; Strahlentherapie von gutartigen Erkrankungen: eine Bestandsaufnahme fuer Deutschland

Energy Technology Data Exchange (ETDEWEB)

Seegenschmiedt, M.H. [Alfried Krupp Krankenhaus Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Katalinic, A. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Medizinische Statistik und Dokumentation; Makoski, H.B. [Staedtische Kliniken Duisburg (Germany). Strahlenklinik; Haase, W. [St. Vincentius Krankenhaus Karlsruhe (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Gademann, G. [Magdeburg Univ. (Germany). Klinik fuer Strahlentherapie; Hassenstein, E. [Krankenhaus Nordwest, Frankfurt am Main (Germany). Radioonkologische Klinik

1999-11-01

A questionnaire was mailed in 3 years (1994, 1995, 1996) to all radiation facilities in Germany, which assessed equipment, indications, number of patients and treatment concepts. A total of 134 (88%) institutions returned all requested data: 22 in East and 112 in West Germany; 30 in university and 104 in community/private hospitals. The average data of each institution and of all institutions were analyzed for frequencies and ratios between different regions and institutions. A mean of 2 (range 1 to 7) megavoltage (Linac/Cobalt 60) and 1.4 (range 0 to 4) orthovoltage units were available per institution; 32 (24%) institutions had no orthovoltage equipment. A mean of 20,082 patients were treated per year: 456 (2%) for inflammatory diseases (221 hidradenitis, 78 nail bed infection, 23 parotitis, 134 not specified), 12,600 (63%) for degenerative diseases (2,711 peritendinitis humeroscapularis, 1,555 epicondylitis humeri, 1,382 heel spur, 2,434 degenerative osteoarthritis, 4,518 not specified), 927 (5%) for hypertrophic diseases (146 Dupuytren's contracture, 382 keloids, 155 Peyronie's disease, 244 not specified), 1,210 (6%) for functional disorders (853 Graves' orbitopathy, 357 not specified), and 4,889 (24%) for other disorders (e.g. 3,680 heterotopic ossification prophylaxis). In univariate analysis, there were significant geographical (West vs East Germany) differences in the use of radiotherapy for inflammatory and degenerative disorders and institutional differences (university vs community/private hospitals) in the use of radiotherapy for hypertrophic and functional disorders (p<0.05). The prescribed dose concepts were mostly in the low dose range (<10 Gy), but varied widely and inconsistently within geographic regions and institution types. (orig./MG) [German] 1994, 1995 und 1996 wurde an alle strahlentherapeutischen Institutionen in Deutschland ein Fragebogen verschickt, mit dem technische Ausstattung, Indikationsspektrum, Patientenzahl und

Svingningsteori, Bd. 1

DEFF Research Database (Denmark)

Nielsen, Søren R. K.

Nærværende lærebog er skrevet med henblik på undervisningen i lineær svingingsteori på konstruktionsliniens 8. semester på Aalborg Universitetscenter. Det pågældende kursus danner grundlaget for efterfølgende undervisning i ikke-lineær svingningsteori, hvilket har påvirket fremstillingens form. D...

Identification of sociodemographic and clinical factors associated with the levels of human β-defensin-1 and human β-defensin-2 in the human milk of Han Chinese.

Science.gov (United States)

Wang, Xiao-Fang; Cao, Rui-Ming; Li, Jing; Wu, Jing; Wu, Sheng-Mei; Chen, Tong-Xin

2014-03-14

Human milk provides infants with various immune molecules. The objective of the present study was to measure human β-defensin-1 (hBD-1) and human β-defensin-2 (hBD-2) levels in the colostrum and mature milk of healthy Han Chinese, to identify factors regulating milk hBD-1 and hBD-2 expression and to explore the potential protective effect of milk hBD-1 and hBD-2 on infants. A total of 100 mothers and their babies were recruited into the study. Sociodemographic characteristics and other factors were obtained by a questionnaire. Babies were followed up for a period of 6 months. Colostrum samples (n 100) and mature milk samples (n 82) were collected by hand expression. The hBD-1 and hBD-2 concentrations were measured by ELISA. The hBD-1 and hBD-2 levels differed in the colostrum and mature milk. In the colostrum, the concentration ranges of hBD-1 and hBD-2 were 1·04-12·81 μg/ml and 0·31-19·12 ng/ml, respectively. In mature milk, the hBD-1 and hBD-2 levels were 1·03-31·76 ng/ml and 52·65-182·29 pg/ml, respectively. Several independent factors influence their production. The multivariable analysis showed a strong association between pre-pregnancy BMI and hBD-1 levels in the colostrum (P=0·001), mode of delivery was significantly associated with hBD-2 levels in the colostrum (P=0·006) and gestational age was significantly associated with hBD-1 levels in mature milk (P= 0·010). During the first 6 months of life, the incidence rate of upper respiratory infection was found to be less in the high-colostrum hBD-1 group than in the low-colostrum hBD-1 group (χ²=4·995, P=0·025). The present study suggested that the abundance of hBD-1 in the colostrum may have a protective function against upper respiratory infection for infants younger than 6 months.

Substance Use Disorders and Suicide Attempts in Bipolar Subtypes

Science.gov (United States)

Sublette, M. Elizabeth; Carballo, Juan J.; Moreno, Carmen; Galfalvy, Hanga C.; Brent, David A.; Birmaher, Boris; Mann, J. John; Oquendo, Maria A.

2009-01-01

1. Abstract Bipolar disorder (BD) is associated with high rates of suicide attempt and completion. Substance use disorders (SUD) have been identified as potent risk factors for suicidal behavior in BD. However, little is known concerning differences between BD subtypes with regard to SUD as a risk factor for suicidal behavior. We studied previous suicidal behavior in adults with a major depressive episode in context of BD type I (BD-I; N=96) or BD type II (BD-II; N=42), with and without history of SUD. Logistic regressions assessed the association between SUD and suicide attempt history by BD type, and exploratory analyses examined the effects of other clinical characteristics on these relationships. SUD were associated with suicide attempt in BD-I but not BD-II, an effect not attributable to sample size differences. The higher suicide attempt rate associated with alcoholism in BD-I was mostly explained by higher aggression scores, and earlier age of BD onset increased the likelihood that alcohol use disorder would be associated with suicide attempt(s). The higher suicide attempt rate associated with other drug use disorders in BD-I was collectively explained by higher impulsivity, hostility, and aggression scores. The presence of both alcohol and drug use disorders increased odds of a history of suicide attempt in a multiplicative fashion: 97% of BD-I who had both comorbid drug and alcohol use disorders had made a suicide attempt. A critical next question is how to target SUD and aggressive traits for prevention of suicidal behavior in BD-I. PMID:18590916

Widespread presence of the pathogenic fungus Batrachochytrium dendrobatidis in wild amphibian communities in Madagascar

Science.gov (United States)

Bletz, Molly C.; Rosa, Gonçalo M.; Andreone, Franco; Courtois, Elodie A.; Schmeller, Dirk S.; Rabibisoa, Nirhy H. C.; Rabemananjara, Falitiana C. E.; Raharivololoniaina, Liliane; Vences, Miguel; Weldon, Ché; Edmonds, Devin; Raxworthy, Christopher J.; Harris, Reid N.; Fisher, Matthew C.; Crottini, Angelica

2015-01-01

Amphibian chytridiomycosis, an emerging infectious disease caused by the fungus Batrachochytrium dendrobatidis (Bd), has been a significant driver of amphibian declines. While globally widespread, Bd had not yet been reported from within Madagascar. We document surveys conducted across the country between 2005 and 2014, showing Bd's first record in 2010. Subsequently, Bd was detected in multiple areas, with prevalence reaching up to 100%. Detection of Bd appears to be associated with mid to high elevation sites and to have a seasonal pattern, with greater detectability during the dry season. Lineage-based PCR was performed on a subset of samples. While some did not amplify with any lineage probe, when a positive signal was observed, samples were most similar to the Global Panzootic Lineage (BdGPL). These results may suggest that Bd arrived recently, but do not exclude the existence of a previously undetected endemic Bd genotype. Representatives of all native anuran families have tested Bd-positive, and exposure trials confirm infection by Bd is possible. Bd's presence could pose significant threats to Madagascar's unique “megadiverse” amphibians. PMID:25719857

Hollandi Heineken võib Saksa õlletootja Krombacheri üle võtta / Katri Soe-Suren

Index Scriptorium Estoniae

Soe-Suren, Katri

2008-01-01

Financial Times Deutschland andmetel plaanib Hollandi Heinekeni kontsern Saksa õlletootja Krombacheri ülevõtmist, Heinekeni sunnib laienema USA päritolu Anheuser-Buschi ülevõtmine InBevi poolt juuli keskpaigas. Lisa

Menschenrechtliche Grenzen des polizeilichen Unterbindungsgewahrsams / Joachim Renzikowski, Reimund Schmidt-De Caluwe

Index Scriptorium Estoniae

Renzikowski, Joachim

2013-01-01

Politsei poolt vahi all pidamise inimõiguslikest piiridest. Vastavast kohtulahendist (Schwabe und M. G. gegen Deutschland), mis puudutab inimõiguste ja põhivabaduste kaitse konventsiooni art. 5 lk. 1 ja art. 11

A cost-effectiveness analysis of calcipotriol plus betamethasone dipropionate aerosol foam versus gel for the topical treatment of plaque psoriasis.

Science.gov (United States)

Foley, Peter; Garrett, Sinead; Ryttig, Lasse

2018-01-24

Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. To determine the cost-effectiveness of Cal/BD foam compared with Cal/BD gel from the Australian perspective. A Markov model was developed to evaluate the cost-effectiveness of topical Cal/BD foam and gel for the treatment of people with plaque psoriasis. Treatment effectiveness, safety, and utilities were based on a randomized control trial, resource use was informed by expert opinion, and unit costs were obtained from public sources. Outcomes were reported in terms of 1-year costs, quality-adjusted life years, and incremental cost-effectiveness ratios. All costs were reported in 2017 Australian Dollars. The model showed that patients using Cal/BD foam had more QALYs and higher costs over 1 year compared with patients using Cal/BD gel, resulting in a cost of $13,609 per QALY gained at 4-weeks. When 4 weeks of Cal/BD foam was compared with 8 weeks of Cal/BD gel treatment, Cal/BD foam was $8 less expensive and resulted in 0.006 more QALYs gained. Sensitivity analyses showed that, compared with Cal/BD ointment, Cal/BD foam was associated with an incremental cost of $15,091 per QALY gained. Cal/BD foam is the most cost-effective Cal/BD formulation for the topical treatment of patients with plaque psoriasis.

Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS

Directory of Open Access Journals (Sweden)

Yongjian Wu

2018-02-01

Full Text Available Beta-defensins 2 and 3 (BD2 and BD3 are inducible peptides present at the sites of infection, and they are well characterized for their antimicrobial activities and immune-regulatory functions. However, no study has thoroughly investigated their immunomodulatory effects on macrophage-mediated immune responses against Pseudomonas aeruginosa (PA. Here, we use THP-1 and RAW264.7 cell lines and demonstrate that BD2 and BD3 suppressed macrophage autophagy but enhanced the engulfment of PA and Zymosan bioparticles as well as the formation of phagolysosomes, using immunofluorescence staining and confocal microscopy. Plate count assay showed that macrophage-mediated phagocytosis and intracellular killing of PA were promoted by BD2 and BD3. Furthermore, microarray and real-time PCR showed that the expression of two genes, early growth response gene-1 (EGR1 and c-FOS, was attenuated by BD2 and BD3. Western blot revealed that BD2 and BD3 inhibited the expression and nuclear translocation of EGR1 and c-FOS. Knockdown of EGR1 and c-FOS by siRNA transfection suppressed macrophage autophagy before and after PA infection; while overexpression of these two transcription factors enhanced autophagy but reversed the role of BD2 and BD3 on macrophage-mediated PA eradication. Together, these results demonstrate a novel immune defense activity of BD2 and BD3, which promotes clearance of PA by inhibiting macrophage autophagy through downregulation of EGR1 and c-FOS.

Stenting und technische Stentumgebung

Science.gov (United States)

Hoffstetter, Marc; Pfeifer, Stefan; Schratzenstaller, Thomas; Wintermantel, Erich

In hoch entwickelten Industrieländern stehen laut Weltgesundheitsorganisation (WHO) Herz-Kreislauf-Erkrankungen und speziell die Koronare Herzkrankheit (KHK) an erster Stelle der Todesursachen. In Deutschland betrug die Zahl der erfassten, an KHK erkrankten Personen ohne Berücksichtigung der Dunkelziffer allein im Jahre 2001 über 473.000. Die KHK war im Jahre 2003 mit 92.673 erfassten Todesfällen immer noch die häufigste Todesursache, obgleich in Deutschland die Häufigkeit der Koronarinterventionen zur Behandlung der KHK zwischen 1984 und 2003 um fast das 80fache von 2.809 auf 221.867 Eingriffe pro Jahr gestiegen ist [1]. Neben der hohen Zahl an Todesfällen haben die betroffenen Personen durch chronische Schmerzen und eingeschränkte körperliche Leistungsfähigkeit zusätzlich eine starke Beeinträchtigung der Lebensqualität [2].In Folge dessen wird die erkrankte Person häufig zum Pflegefall was neben den gesundheitlichen Aspekten auch eine sozioökonomische Komponente in Form der fehlenden Arbeitskraft und den auftretenden Pflegekosten nach sich zieht. Die Kosten für die Behandlung der KHK in Deutschland beliefen sich im Jahre 2002 laut Statistischem Bundesamt auf rund 6,9 Mrd. €. Verglichen mit ähnlichen Zahlen der USA dürfte sich der entstandene Schaden für die deutsche Volkswirtschaft im zwei- bis dreistelligen Milliardenbereich bewegen [3].

Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241.

Science.gov (United States)

Zhang, Liaoyuan; Guo, Zewang; Chen, Jiebo; Xu, Quanming; Lin, Hui; Hu, Kaihui; Guan, Xiong; Shen, Yaling

2016-01-12

Serratia sp. T241, a newly isolated xylose-utilizing strain, produced three 2,3-butanediol (2,3-BD) stereoisomers. In this study, three 2,3-butanediol dehydrogenases (BDH1-3) and one glycerol dehydrogenase (GDH) involved in 2,3-BD isomers formation by Serratia sp. T241 were identified. In vitro conversion showed BDH1 and BDH2 could catalyzed (3S)-acetoin and (3R)-acetoin into (2S,3S)-2,3-BD and meso-2,3-BD, while BDH3 and GDH exhibited the activities from (3S)-acetoin and (3R)-acetoin to meso-2,3-BD and (2R,3R)-2,3-BD. Four encoding genes were assembled into E. coli with budA (acetolactate decarboxylase) and budB (acetolactate synthase), responsible for converting pyruvate into acetoin. E. coli expressing budAB-bdh1/2 produced meso-2,3-BD and (2S,3S)-2,3-BD. Correspondingly, (2R,3R)-2,3-BD and meso-2,3-BD were obtained by E. coli expressing budAB-bdh3/gdh. These results suggested four enzymes might contribute to 2,3-BD isomers formation. Mutants of four genes were developed in Serratia sp. T241. Δbdh1 led to reduced concentration of meso-2,3-BD and (2S,3S)-2,3-BD by 97.7% and 87.9%. (2R,3R)-2,3-BD with a loss of 73.3% was produced by Δbdh3. Enzyme activity assays showed the decrease of 98.4% and 22.4% by Δbdh1 and Δbdh3 compared with the wild strain. It suggested BDH1 and BDH3 played important roles in 2,3-BD formation, BDH2 and GDH have small effects on 2,3-BD production by Serratia sp. T241.

Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder

Energy Technology Data Exchange (ETDEWEB)

Song, Y.R. [Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Wu, B. [Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Yang, Y.T.; Chen, J. [Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Zhang, L.J.; Zhang, Z.W. [Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Shi, H.Y. [Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Huang, C.L.; Pan, J.X. [Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China); Xie, P. [Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Chongqing Key Laboratory of Neurobiology, Chongqing (China); Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing (China)

2015-09-08

Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2% of the general population of different European countries. Unfortunately, there is no objective laboratory-based test to aid BD diagnosis or monitor its progression, and little is known about the molecular basis of BD. Here, we performed a comparative proteomic study to identify differentially expressed plasma proteins in various BD mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched healthy control subjects were recruited. Seven high-abundance proteins were immunodepleted in plasma samples from the 4 experimental groups, which were then subjected to proteome-wide expression profiling by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem mass spectrometry. Proteomic results were validated by immunoblotting and bioinformatically analyzed using MetaCore. From a total of 32 proteins identified with 1.5-fold changes in expression compared with healthy controls, 16 proteins were perturbed in BD independent of mood state, while 16 proteins were specifically associated with particular BD mood states. Two mood-independent differential proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be associated with early perturbations in lipid metabolism. Moreover, down-regulation of one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be associated with early perturbations in lipid metabolism that are independent of mood state, while CA-1 may be involved in the pathophysiology of depressive episodes.

Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder

International Nuclear Information System (INIS)

Song, Y.R.; Wu, B.; Yang, Y.T.; Chen, J.; Zhang, L.J.; Zhang, Z.W.; Shi, H.Y.; Huang, C.L.; Pan, J.X.; Xie, P.

2015-01-01

Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2% of the general population of different European countries. Unfortunately, there is no objective laboratory-based test to aid BD diagnosis or monitor its progression, and little is known about the molecular basis of BD. Here, we performed a comparative proteomic study to identify differentially expressed plasma proteins in various BD mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched healthy control subjects were recruited. Seven high-abundance proteins were immunodepleted in plasma samples from the 4 experimental groups, which were then subjected to proteome-wide expression profiling by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem mass spectrometry. Proteomic results were validated by immunoblotting and bioinformatically analyzed using MetaCore. From a total of 32 proteins identified with 1.5-fold changes in expression compared with healthy controls, 16 proteins were perturbed in BD independent of mood state, while 16 proteins were specifically associated with particular BD mood states. Two mood-independent differential proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be associated with early perturbations in lipid metabolism. Moreover, down-regulation of one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be associated with early perturbations in lipid metabolism that are independent of mood state, while CA-1 may be involved in the pathophysiology of depressive episodes

Historical amphibian declines and extinctions in Brazil linked to chytridiomycosis.

Science.gov (United States)

Carvalho, Tamilie; Becker, C Guilherme; Toledo, Luís Felipe

2017-02-08

The recent increase in emerging fungal diseases is causing unprecedented threats to biodiversity. The origin of spread of the frog-killing fungus Batrachochytrium dendrobatidis ( Bd ) is a matter of continued debate. To date, the historical amphibian declines in Brazil could not be attributed to chytridiomycosis; the high diversity of hosts coupled with the presence of several Bd lineages predating the reported declines raised the hypothesis that a hypervirulent Bd genotype spread from Brazil to other continents causing the recent global amphibian crisis. We tested for a spatio-temporal overlap between Bd and areas of historical amphibian population declines and extinctions in Brazil. A spatio-temporal convergence between Bd and declines would support the hypothesis that Brazilian amphibians were not adapted to Bd prior to the reported declines, thus weakening the hypothesis that Brazil was the global origin of Bd emergence. Alternatively, a lack of spatio-temporal association between Bd and frog declines would indicate an evolution of host resistance in Brazilian frogs predating Bd 's global emergence , further supporting Brazil as the potential origin of the Bd panzootic. Here, we Bd -screened over 30 000 museum-preserved tadpoles collected in Brazil between 1930 and 2015 and overlaid spatio-temporal Bd data with areas of historical amphibian declines. We detected an increase in the proportion of Bd -infected tadpoles during the peak of amphibian declines (1979-1987). We also found that clusters of Bd -positive samples spatio-temporally overlapped with most records of amphibian declines in Brazil's Atlantic Forest. Our findings indicate that Brazil is post epizootic for chytridiomycosis and provide another piece to the puzzle to explain the origin of Bd globally. © 2017 The Author(s).

Historical amphibian declines and extinctions in Brazil linked to chytridiomycosis

Science.gov (United States)

Carvalho, Tamilie; Becker, C. Guilherme

2017-01-01

The recent increase in emerging fungal diseases is causing unprecedented threats to biodiversity. The origin of spread of the frog-killing fungus Batrachochytrium dendrobatidis (Bd) is a matter of continued debate. To date, the historical amphibian declines in Brazil could not be attributed to chytridiomycosis; the high diversity of hosts coupled with the presence of several Bd lineages predating the reported declines raised the hypothesis that a hypervirulent Bd genotype spread from Brazil to other continents causing the recent global amphibian crisis. We tested for a spatio-temporal overlap between Bd and areas of historical amphibian population declines and extinctions in Brazil. A spatio-temporal convergence between Bd and declines would support the hypothesis that Brazilian amphibians were not adapted to Bd prior to the reported declines, thus weakening the hypothesis that Brazil was the global origin of Bd emergence. Alternatively, a lack of spatio-temporal association between Bd and frog declines would indicate an evolution of host resistance in Brazilian frogs predating Bd's global emergence, further supporting Brazil as the potential origin of the Bd panzootic. Here, we Bd-screened over 30 000 museum-preserved tadpoles collected in Brazil between 1930 and 2015 and overlaid spatio-temporal Bd data with areas of historical amphibian declines. We detected an increase in the proportion of Bd-infected tadpoles during the peak of amphibian declines (1979–1987). We also found that clusters of Bd-positive samples spatio-temporally overlapped with most records of amphibian declines in Brazil's Atlantic Forest. Our findings indicate that Brazil is post epizootic for chytridiomycosis and provide another piece to the puzzle to explain the origin of Bd globally. PMID:28179514

Heterogeneous occupancy and density estimates of the pathogenic fungus Batrachochytrium dendrobatidis in waters of North America.

Directory of Open Access Journals (Sweden)

Tara Chestnut

Full Text Available Biodiversity losses are occurring worldwide due to a combination of stressors. For example, by one estimate, 40% of amphibian species are vulnerable to extinction, and disease is one threat to amphibian populations. The emerging infectious disease chytridiomycosis, caused by the aquatic fungus Batrachochytrium dendrobatidis (Bd, is a contributor to amphibian declines worldwide. Bd research has focused on the dynamics of the pathogen in its amphibian hosts, with little emphasis on investigating the dynamics of free-living Bd. Therefore, we investigated patterns of Bd occupancy and density in amphibian habitats using occupancy models, powerful tools for estimating site occupancy and detection probability. Occupancy models have been used to investigate diseases where the focus was on pathogen occurrence in the host. We applied occupancy models to investigate free-living Bd in North American surface waters to determine Bd seasonality, relationships between Bd site occupancy and habitat attributes, and probability of detection from water samples as a function of the number of samples, sample volume, and water quality. We also report on the temporal patterns of Bd density from a 4-year case study of a Bd-positive wetland. We provide evidence that Bd occurs in the environment year-round. Bd exhibited temporal and spatial heterogeneity in density, but did not exhibit seasonality in occupancy. Bd was detected in all months, typically at less than 100 zoospores L(-1. The highest density observed was ∼3 million zoospores L(-1. We detected Bd in 47% of sites sampled, but estimated that Bd occupied 61% of sites, highlighting the importance of accounting for imperfect detection. When Bd was present, there was a 95% chance of detecting it with four samples of 600 ml of water or five samples of 60 mL. Our findings provide important baseline information to advance the study of Bd disease ecology, and advance our understanding of amphibian exposure to free

Reaction behaviour of DSD waste plastics in hydrogenating liquefaction with varied times of residue and reaction temperatures; Das Reaktionsverhalten von DSD-Kunststoffabfaellen in der hydrierenden Verfluessigung bei Variation von Verweilzeit und Reaktionstemperatur

Energy Technology Data Exchange (ETDEWEB)

Burgtorf, J; Meier zu Koecker, H [Technische Univ. Berlin (Germany). Inst. fuer Energietechnik

1997-12-31

Hydrogenation is an established process of waste plastics recycling. At the 1st DGMK Technical Meeting at Velen, the Energy Engineering Institute of Berlin Technical University presented studies on the reaction behaviour of waste plastics collected by the DSD (Duales System Deutschland) during hydrogenating liquefaction. The studies have been finished by now, and some results are presented, with particular regard to times of residue and reaction temperaperatures. (orig) [Deutsch] Die Hydrierung ist ein etabliertes Verfahren der rohstofflichen Verwertung von Kunststoffabfaellen. Die auf der 1. DGMK-Fachtagung in Velen vorgestellten Arbeiten des Instituts fuer Energietechnik der Technischen Universitaet Berlin zum Reaktionsverhalten von Kuststoffabfaellen aus der Sammlung des Dualen Systems Deutschland (DSD) in der hydrierenden Verfluessigung sind inzwischen abgeschlossen. Einige Ergebnisse werden hier unter besonderer Beruecksichtigung der Parameter Verweilzeit und Reaktionstemperatur dargestellt. (orig)

Reaction behaviour of DSD waste plastics in hydrogenating liquefaction with varied times of residue and reaction temperatures; Das Reaktionsverhalten von DSD-Kunststoffabfaellen in der hydrierenden Verfluessigung bei Variation von Verweilzeit und Reaktionstemperatur

Energy Technology Data Exchange (ETDEWEB)

Burgtorf, J.; Meier zu Koecker, H. [Technische Univ. Berlin (Germany). Inst. fuer Energietechnik

1996-12-31

Hydrogenation is an established process of waste plastics recycling. At the 1st DGMK Technical Meeting at Velen, the Energy Engineering Institute of Berlin Technical University presented studies on the reaction behaviour of waste plastics collected by the DSD (Duales System Deutschland) during hydrogenating liquefaction. The studies have been finished by now, and some results are presented, with particular regard to times of residue and reaction temperaperatures. (orig) [Deutsch] Die Hydrierung ist ein etabliertes Verfahren der rohstofflichen Verwertung von Kunststoffabfaellen. Die auf der 1. DGMK-Fachtagung in Velen vorgestellten Arbeiten des Instituts fuer Energietechnik der Technischen Universitaet Berlin zum Reaktionsverhalten von Kuststoffabfaellen aus der Sammlung des Dualen Systems Deutschland (DSD) in der hydrierenden Verfluessigung sind inzwischen abgeschlossen. Einige Ergebnisse werden hier unter besonderer Beruecksichtigung der Parameter Verweilzeit und Reaktionstemperatur dargestellt. (orig)

Developing an electromobile future. Battery research is key.; Elektromobil in die Zukunft. Batterieforschung als Schluessel

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

This document describes the goals of the German federal government in making Germany a lead market for electromobility. It is divided into three chapters: 1. Batteries for electromobiles (research institutions, companies); 2. Strategies for battery research in Germany (building competence, creating networks, forming European alliances); and 3. Challenges in strategy implementation (a focus on battery materials, electrochemistry, research in the fields of battery production and battery systems integration). [German] In diesem Dokument werden die Ziele der Bundesregierung beschrieben wie sie Deutschland zu einem Leitmarkt fuer Elektromobilitaet machen will. Es ist in drei Kapitel aufgeteilt: 1. Batterien fuer Elektrofahrzuege (Forschungseinrichtungen, Unternehmen); 2. Strategie fuer die Batterieforschung in Deutschland (Kompetenzen aufbauen, Netzwerke knuepfen, europaeische Allianzen bilden) und 3. Herausforderungen bei der Umsetzung der Strategie (Fokus auf Batteriematerialien, Elektrochemie, Forschung fuer die Batterieproduktion sowie Batteriesystemintegration).

Particle Reduction Strategies - PAREST. Energy scenarios for PAREST. Sub-report; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Energieszenarien fuer PAREST. Teilbericht

Energy Technology Data Exchange (ETDEWEB)

Joerss, Wolfram; Degel, Melanie [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

2013-06-15

In the research project PAREST emission scenarios to 2020 for particulate matter (PM{sub 10} und PM{sub 2,5}), and aerosol precursors SO{sub 2}, NO{sub x}, NH{sub 3} and NMVOC were prepared for Germany and Europe, mitigation measures evaluated and the results used to model the PM pollution load for Germany. In this part of the report to PAREST energy scenarios used for PAREST are presented. [German] Im Forschungsvorhaben PAREST wurden Emissionsszenarien bis 2020 fuer Feinstaub (PM{sub 10} und PM{sub 2,5}) und die Aerosol-Vorlaeufersubstanzen SO{sub 2}, NO{sub x}, NH{sub 3} und NMVOC fuer Deutschland und Europa erstellt, Minderungsmassnahmen evaluiert und daraus die PM-Immissionsbelastung fuer Deutschland modelliert. In diesem Teilbericht zu PAREST werden die fuer PAREST benutzten Energieszenarien vorgestellt.

Aus der Forschungspraxis: Journalism in a Global Context – Perspektiven für Afrika und Herausforderungen für Europa

Directory of Open Access Journals (Sweden)

Susanne Fengler

2016-08-01

Full Text Available In der gegenwärtigen Flüchtlingskrise zeigt sich auf eklatante Weise das Informationsdefizit, das die gegenseitige mediale Wahrnehmung der europäischen und afrikanischen Länder bestimmt. Während in Deutschland und Europa Fluchtursachen und -motive zumeist junger afrikanischer Migranten falsch eingeschätzt und innerkontinentale Migrationsprozesse in Afrika nur marginal in europäischen Medien thematisiert werden, nehmen auch viele Menschen in afrikanischen Ländern nur Ausschnitte aus der Realität des Lebens in Deutschland bzw. Europa wahr. Hieran hat auch die mangelnde Medienberichterstattung in afrikanischen Ländern über Hintergründe und Folgen der Flüchtlingsbewegungen erheblichen Anteil. Der Werkstattbericht bietet auf Grundlage von zwei deutsch-afrikanischen Konferenzen, Literatursichtung und eigenen Studien eine Einschätzung der Berichterstattung auf beiden Kontinenten.

American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence.

Science.gov (United States)

Dell'Osso, Bernardo; Shah, Saloni; Do, Dennis; Yuen, Laura D; Hooshmand, Farnaz; Wang, Po W; Miller, Shefali; Ketter, Terence A

2017-12-01

Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD type II (BD II) versus type I (BD I) in relation to time to depressive recurrence and recovery from major depressive episode. We therefore assessed times to depressive recurrence/recovery in tertiary clinic-referred BD II versus I patients. Outpatients referred to Stanford BD Clinic during 2000-2011 were assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and with Clinical Monitoring Form during up to 2 years of naturalistic treatment. Prevalence and clinical correlates of bipolar subtype in recovered (euthymic ≥8 weeks) and depressed patients were assessed. Kaplan-Meier analyses assessed the relationships between bipolar subtype and longitudinal depressive severity, and Cox proportional hazard analyses assessed the potential mediators. BD II versus BD I was less common among 105 recovered (39.0 vs. 61.0%, p = 0.03) and more common among 153 depressed (61.4 vs. 38.6%, p = 0.006) patients. Among recovered patients, BD II was associated with 6/25 (24.0%) baseline unfavorable illness characteristics/mood symptoms/psychotropics and hastened depressive recurrence (p = 0.015). Among depressed patients, BD II was associated with 8/25 (33.0%) baseline unfavorable illness characteristics/mood symptoms/psychotropics, but only non-significantly associated with delayed depressive recovery. BD II versus BD I was significantly associated with current depression and hastened depressive recurrence, but only non-significantly associated with delayed depressive recovery. Research on bipolar subtype relationships with depressive recurrence/recovery is warranted to enhance clinical management of BD patients.

Awareness of breast density and its impact on breast cancer detection and risk.

Science.gov (United States)

Rhodes, Deborah J; Radecki Breitkopf, Carmen; Ziegenfuss, Jeanette Y; Jenkins, Sarah M; Vachon, Celine M

2015-04-01

Legislation mandating disclosure of breast density (BD) information has passed in 21 states; however, actual awareness of BD and knowledge of its impact on breast cancer detection and risk are unknown. We conducted a national cross-sectional survey administered in English and Spanish using a probability-based sample of screening-age women, with oversampling of Connecticut, the only state with BD legislation in effect for > 1 year before the survey. Of 2,311 women surveyed, 65% responded. Overall, 58% of women had heard of BD, 49% knew that BD affects breast cancer detection, and 53% knew that BD affects cancer risk. After multivariable adjustment, increased BD awareness was associated with white non-Hispanic race/ethnicity (Hispanic v white non-Hispanic: odds ratio [OR], 0.23; P awareness and knowledge exist by race/ethnicity, education, and income. BD legislation seems to be effective in increasing knowledge of BD impact on breast cancer detection. These findings support continued and targeted efforts to improve BD awareness and knowledge among women eligible for screening mammography. © 2015 by American Society of Clinical Oncology.

Katrina Historical Page - Office of Satellite and Product Operations

Science.gov (United States)

. Floater Imagery August 28/1745Z to 29/0245Z: Image: AVN | BD | FT | IR | IR2 | JSL | RB | RGB | VIS | WV Image (w/ Latitude & Longitude): AVN | BD | FT | IR | IR2 | JSL | RB | RGB | VIS | WV Loop: AVN | BD : AVN | BD | FT | IR | IR2 | JSL | RB | RGB | VIS | WV Image (w/ Latitude & Longitude): AVN | BD

The local clinical validation of a new lithium heparin tube with a barrier: BD Vacutainer® Barricor LH Plasma tube

Science.gov (United States)

Arslan, Fatma Demet; Karakoyun, Inanc; Basok, Banu Isbilen; Aksit, Merve Zeytinli; Baysoy, Anil; Ozturk, Yasemin Kilic; Guclu, Yusuf Adnan; Duman, Can

2017-01-01

Introduction Although serum-providing blood tubes with a barrier are still widely used due to their significant advantages, the use of blood tubes with a barrier to provide plasma is becoming widespread. We compared 22 analytes in a BD Vacutainer® Barricor LH Plasma tube for local clinical validation of this new lithium heparin tube with a barrier. Materials and methods Samples from 44 volunteers were collected in different tubes (Becton Dickinson and Company): Z tube without additive (reference), clot-activator tube with gel (SST), lithium heparin tube without gel (LiH), and lithium heparin tube with barrier (Barricor). Analyte concentrations in different tubes were compared with the reference tube. All tubes were also evaluated according to additional testing (different centrifugation durations, blood-sampling techniques and individual differences). Results Aspartate aminotransferase (AST), glucose (Glc), potassium (K), lactate dehydrogenase (LD), sodium (Na), and total protein (TP) had a significant bias in Barricor (9.19%, - 3.24%, - 4.88%, 21.60%, - 0.40%, 5.03%, respectively) relative to the reference tube. There was no statistical difference between different centrifugation durations and individual differences for AST, K and LD in LiH and/or Barricor (P > 0.05). There was a significant bias for LD between LiH and Barricor in terms of blood-sampling techniques (21.2% and 12.4%, respectively). Conclusions Recently, the use of plasma has become prominent due to some of its advantages. In this study, plasma AST, K, LD, Glc and TP levels in Barricor were clinically different in comparison to serum. The results of additional tests showed that higher levels of LD in Barricor did not result from haemolysis, and they might be related to other factors including number of platelets, cellular fragility, or functional environment. PMID:28900369

The local clinical validation of a new lithium heparin tube with a barrier: BD Vacutainer® Barricor LH Plasma tube.

Science.gov (United States)

Arslan, Fatma Demet; Karakoyun, Inanc; Basok, Banu Isbilen; Aksit, Merve Zeytinli; Baysoy, Anil; Ozturk, Yasemin Kilic; Guclu, Yusuf Adnan; Duman, Can

2017-10-15

Although serum-providing blood tubes with a barrier are still widely used due to their significant advantages, the use of blood tubes with a barrier to provide plasma is becoming widespread. We compared 22 analytes in a BD Vacutainer® Barricor LH Plasma tube for local clinical validation of this new lithium heparin tube with a barrier. Samples from 44 volunteers were collected in different tubes (Becton Dickinson and Company): Z tube without additive (reference), clot-activator tube with gel (SST), lithium heparin tube without gel (LiH), and lithium heparin tube with barrier (Barricor). Analyte concentrations in different tubes were compared with the reference tube. All tubes were also evaluated according to additional testing (different centrifugation durations, blood-sampling techniques and individual differences). Aspartate aminotransferase (AST), glucose (Glc), potassium (K), lactate dehydrogenase (LD), sodium (Na), and total protein (TP) had a significant bias in Barricor (9.19%, - 3.24%, - 4.88%, 21.60%, - 0.40%, 5.03%, respectively) relative to the reference tube. There was no statistical difference between different centrifugation durations and individual differences for AST, K and LD in LiH and/or Barricor (P > 0.05). There was a significant bias for LD between LiH and Barricor in terms of blood-sampling techniques (21.2% and 12.4%, respectively). Recently, the use of plasma has become prominent due to some of its advantages. In this study, plasma AST, K, LD, Glc and TP levels in Barricor were clinically different in comparison to serum. The results of additional tests showed that higher levels of LD in Barricor did not result from haemolysis, and they might be related to other factors including number of platelets, cellular fragility, or functional environment.

The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer’s type

Directory of Open Access Journals (Sweden)

Ivan Aprahamian

2014-12-01

Full Text Available There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD with dementia. Objective To investigate the Clock Drawing Test (CDT among older adults with BD with and without Alzheimer’s disease (AD. Method 209 older adults (79 with BD without dementia and 70 controls; 60 with AD, being 27 with BD were included to evaluate the performance of three CDT scoring scales, beyond the Mini-Mental State Examination (MMSE and verbal fluency (VFT. Results Patients with BD without dementia presented with lower scores in MMSE, VF and one CDT scoring scale than controls. Patients with BD and AD presented with lower scores in VF and CDT scoring scales than patients with only AD. All CDT scales presented similar sensitivity and specificity for BD and non-BD groups. Conclusion Elderly subjects with BD showed greater impairment in CDT in both groups of normal cognition and AD.

Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

International Nuclear Information System (INIS)

Yanamala, Naveena; Hatfield, Meghan K.; Farcas, Mariana T.; Schwegler-Berry, Diane; Hummer, Jon A.; Shurin, Michael R.; Birch, M. Eileen; Gutkin, Dmitriy W.; Kisin, Elena; Kagan, Valerian E.; Bugarski, Aleksandar D.; Shvedova, Anna A.

2013-01-01

The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsaturated fatty acids, we hypothesize that BD exhaust particles could induce pronounced adverse outcomes, due to their ability to readily oxidize. The main objective of this study was to compare the effects of particles generated by engine fueled with neat BD and neat petroleum-based D. Biomarkers of tissue damage and inflammation were significantly elevated in lungs of mice exposed to BD particulates. Additionally, BD particulates caused a significant accumulation of oxidatively modified proteins and an increase in 4-hydroxynonenal. The up-regulation of inflammatory cytokines/chemokines/growth factors was higher in lungs upon BD particulate exposure. Histological evaluation of lung sections indicated presence of lymphocytic infiltrate and impaired clearance with prolonged retention of BD particulate in pigment laden macrophages. Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D. - Highlights: • Exposure of mice to BDPM caused higher pulmonary toxicity compared to DPM. • Oxidative stress and inflammation were higher in BD vs to D exposed mice. • Inflammatory lymphocyte infiltrates were seen only in lungs of mice exposed to BD. • Ineffective clearance, prolonged PM retention was present only after BD exposure

Neuropsychological and social cognitive function in young people at genetic risk of bipolar disorder.

Science.gov (United States)

McCormack, C; Green, M J; Rowland, J E; Roberts, G; Frankland, A; Hadzi-Pavlovic, D; Joslyn, C; Lau, P; Wright, A; Levy, F; Lenroot, R K; Mitchell, P B

2016-03-01

Impairments in key neuropsychological domains (e.g. working memory, attention) and social cognitive deficits have been implicated as intermediate (endo) phenotypes for bipolar disorder (BD), and should therefore be evident in unaffected relatives. Neurocognitive and social cognitive ability was examined in 99 young people (age range 16-30 years) with a biological parent or sibling diagnosed with the disorder [thus deemed to be at risk (AR) of developing BD], compared with 78 healthy control (HC) subjects, and 52 people with a confirmed diagnosis of BD. Only verbal intelligence and affective response inhibition were significantly impaired in AR relative to HC participants; the BD participants showed significant deficits in attention tasks compared with HCs. Neither AR nor BD patients showed impairments in general intellectual ability, working memory, visuospatial or language ability, relative to HC participants. Analysis of BD-I and BD-II cases separately revealed deficits in attention and immediate memory in BD-I patients (only), relative to HCs. Only the BD (but not AR) participants showed impaired emotion recognition, relative to HCs. Selective cognitive deficits in the capacity to inhibit negative affective information, and general verbal ability may be intermediate markers of risk for BD; however, the extent and severity of impairment in this sample was less pronounced than has been reported in previous studies of older family members and BD cases. These findings highlight distinctions in the cognitive profiles of AR and BD participants, and provide limited support for progressive cognitive decline in association with illness development in BD.

Unlocking the story in the swab: A new genotyping assay for the amphibian chytrid fungus Batrachochytrium dendrobatidis.

Science.gov (United States)

Byrne, Allison Q; Rothstein, Andrew P; Poorten, Thomas J; Erens, Jesse; Settles, Matthew L; Rosenblum, Erica Bree

2017-11-01

One of the most devastating emerging pathogens of wildlife is the chytrid fungus, Batrachochytrium dendrobatidis (Bd), which affects hundreds of amphibian species around the world. Genomic data from pure Bd cultures have advanced our understanding of Bd phylogenetics, genomic architecture and mechanisms of virulence. However, pure cultures are laborious to obtain and whole-genome sequencing is comparatively expensive, so relatively few isolates have been genetically characterized. Thus, we still know little about the genetic diversity of Bd in natural systems. The most common noninvasive method of sampling Bd from natural populations is to swab amphibian skin. Hundreds of thousands of swabs have been collected from amphibians around the world, but Bd DNA collected via swabs is often low in quality and/or quantity. In this study, we developed a custom Bd genotyping assay using the Fluidigm Access Array platform to amplify 192 carefully selected regions of the Bd genome. We obtained robust sequence data for pure Bd cultures and field-collected skin swabs. This new assay has the power to accurately discriminate among the major Bd clades, recovering the basic tree topology previously revealed using whole-genome data. Additionally, we established a critical value for initial Bd load for swab samples (150 Bd genomic equivalents) above which our assay performs well. By leveraging advances in microfluidic multiplex PCR technology and the globally distributed resource of amphibian swab samples, noninvasive skin swabs can now be used to address critical spatial and temporal questions about Bd and its effects on declining amphibian populations. © 2017 John Wiley & Sons Ltd.

Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

Energy Technology Data Exchange (ETDEWEB)

Yanamala, Naveena, E-mail: wqu1@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Hatfield, Meghan K., E-mail: wla4@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Farcas, Mariana T., E-mail: woe7@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Schwegler-Berry, Diane [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Hummer, Jon A., E-mail: qzh3@cdc.gov [Office of Mine Safety and Health Research/NIOSH/CDC, Pittsburgh, PA 15236 (United States); Shurin, Michael R., E-mail: shurinmr@upmc.edu [Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Birch, M. Eileen, E-mail: mib2@cdc.gov [NIOSH/CDC, 4676 Columbia Parkway, Cincinnati, OH 45226 (United States); Gutkin, Dmitriy W., E-mail: dwgutkin@hotmail.com [Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Kisin, Elena, E-mail: edk8@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Kagan, Valerian E., E-mail: kagan@pitt.edu [Department of Environmental and Occupational Health, University of Pittsburgh, PA (United States); Bugarski, Aleksandar D., E-mail: zjl1@cdc.gov [Office of Mine Safety and Health Research/NIOSH/CDC, Pittsburgh, PA 15236 (United States); Shvedova, Anna A., E-mail: ats1@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Department Physiology and Pharmacology, WVU, Morgantown, WV 26505 (United States)

2013-10-15

The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsaturated fatty acids, we hypothesize that BD exhaust particles could induce pronounced adverse outcomes, due to their ability to readily oxidize. The main objective of this study was to compare the effects of particles generated by engine fueled with neat BD and neat petroleum-based D. Biomarkers of tissue damage and inflammation were significantly elevated in lungs of mice exposed to BD particulates. Additionally, BD particulates caused a significant accumulation of oxidatively modified proteins and an increase in 4-hydroxynonenal. The up-regulation of inflammatory cytokines/chemokines/growth factors was higher in lungs upon BD particulate exposure. Histological evaluation of lung sections indicated presence of lymphocytic infiltrate and impaired clearance with prolonged retention of BD particulate in pigment laden macrophages. Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D. - Highlights: • Exposure of mice to BDPM caused higher pulmonary toxicity compared to DPM. • Oxidative stress and inflammation were higher in BD vs to D exposed mice. • Inflammatory lymphocyte infiltrates were seen only in lungs of mice exposed to BD. • Ineffective clearance, prolonged PM retention was present only after BD exposure.

Expression of host defense peptides in the intestine of Eimeria-challenged chickens.

Science.gov (United States)

Su, S; Dwyer, D M; Miska, K B; Fetterer, R H; Jenkins, M C; Wong, E A

2017-07-01

Avian coccidiosis is caused by the intracellular protozoan Eimeria, which produces intestinal lesions leading to weight gain depression. Current control methods include vaccination and anticoccidial drugs. An alternative approach involves modulating the immune system. The objective of this study was to profile the expression of host defense peptides such as avian beta-defensins (AvBDs) and liver expressed antimicrobial peptide 2 (LEAP2), which are part of the innate immune system. The mRNA expression of AvBD family members 1, 6, 8, 10, 11, 12, and 13 and LEAP2 was examined in chickens challenged with either E. acervulina, E. maxima, or E. tenella. The duodenum, jejunum, ileum, and ceca were collected 7 d post challenge. In study 1, E. acervulina challenge resulted in down-regulation of AvBD1, AvBD6, AvBD10, AvBD11, AvBD12, and AvBD13 in the duodenum. E. maxima challenge caused down-regulation of AvBD6, AvBD10, and AvBD11 in the duodenum, down-regulation of AvBD10 in the jejunum, but up-regulation of AvBD8 and AvBD13 in the ceca. E. tenella challenge showed no change in AvBD expression in any tissue. In study 2, which involved challenge with only E. maxima, there was down-regulation of AvBD1 in the ileum, AvBD11 in the jejunum and ileum, and LEAP2 in all 3 segments of the small intestine. The expression of LEAP2 was further examined by in situ hybridization in the jejunum of chickens from study 2. LEAP2 mRNA was expressed similarly in the enterocytes lining the villi, but not in the crypts of control and Eimeria challenged chickens. The lengths of the villi in the Eimeria challenged chickens were less than those in the control chickens, which may in part account for the observed down-regulation of LEAP2 mRNA quantified by PCR. Overall, the AvBD response to Eimeria challenge was not consistent; whereas LEAP2 was consistently down-regulated, which suggests that LEAP2 plays an important role in modulating an Eimeria infection. Published by Oxford University Press on

Heterogeneous occupancy and density estimates of the pathogenic fungus Batrachochytrium dendrobatidis in waters of North America

Science.gov (United States)

Chestnut, Tara E.; Anderson, Chauncey; Popa, Radu; Blaustein, Andrew R.; Voytek, Mary; Olson, Deanna H.; Kirshtein, Julie

2014-01-01

Biodiversity losses are occurring worldwide due to a combination of stressors. For example, by one estimate, 40% of amphibian species are vulnerable to extinction, and disease is one threat to amphibian populations. The emerging infectious disease chytridiomycosis, caused by the aquatic fungus Batrachochytrium dendrobatidis (Bd), is a contributor to amphibian declines worldwide. Bd research has focused on the dynamics of the pathogen in its amphibian hosts, with little emphasis on investigating the dynamics of free-living Bd. Therefore, we investigated patterns of Bd occupancy and density in amphibian habitats using occupancy models, powerful tools for estimating site occupancy and detection probability. Occupancy models have been used to investigate diseases where the focus was on pathogen occurrence in the host. We applied occupancy models to investigate free-living Bd in North American surface waters to determine Bd seasonality, relationships between Bd site occupancy and habitat attributes, and probability of detection from water samples as a function of the number of samples, sample volume, and water quality. We also report on the temporal patterns of Bd density from a 4-year case study of a Bd-positive wetland. We provide evidence that Bd occurs in the environment year-round. Bd exhibited temporal and spatial heterogeneity in density, but did not exhibit seasonality in occupancy. Bd was detected in all months, typically at less than 100 zoospores L−1. The highest density observed was ∼3 million zoospores L−1. We detected Bd in 47% of sites sampled, but estimated that Bd occupied 61% of sites, highlighting the importance of accounting for imperfect detection. When Bd was present, there was a 95% chance of detecting it with four samples of 600 ml of water or five samples of 60 mL. Our findings provide important baseline information to advance the study of Bd disease ecology, and advance our understanding of amphibian exposure

Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats.

Science.gov (United States)

Wang, Ai-Hong; Ma, Qian; Wang, Xin; Xu, Gui-Hua

2018-02-01

Inflammation has a role in the cerebral injury induced by ischemia and the present study aimed to determine the mechanism of the protective effect of beef decoction (BD) with carnosine against it. A rat model of permanent middle cerebral artery occlusion was established using a suture method in the vehicle and each of the BD groups. In experiment 1, 72 Sprague Dawley (SD) rats were randomly divided into three groups: Sham, vehicle and BD-treated group. Rats in the BD group were given 600 mg/kg BD by oral gavage for 1, 3 and 7 days. The sham and vehicle group rats received an equivalent amount of normal saline. In experiment 2, 60 SD rats were randomly divided into six groups: Sham-operated I, sham-operated II, vehicle, low-dose BD, medium-dose BD and high-dose BD group. Rats in the low-, medium- and high-dose BD groups were given BD at the dose of 200, 400 and 600 mg/kg, respectively, by oral gavage for 7 days. Rats in the sham-operated II group were given 600 mg/kg BD. Rats in the sham-operated I group and vehicle group were given the same volume of normal saline by oral gavage. The body weight, neurological deficits and infarct volume were recorded at 1, 3 and 7 days after the operation. Furthermore, the effect of different doses of BD on interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and interleukin-4 (IL-4) levels in peripheral blood was measured at 7 days. BD-treated rats showed less neurological deficits and a smaller infarct volume at 7 days. BD at 400 and 600 mg/kg significantly decreased the infarct volume in rats. At 600 mg/kg BD, a decline in IL-6, TNF-α, IFN-γ and an increase in IL-4 expression was observed in the BD groups, while no difference in body weight and neurological dysfunction was detected. In conclusion, BD is a neuroprotective agent that may be used as a supplement treatment of ischemic stroke.

Social cognition in patients with schizophrenia spectrum and bipolar disorders with and without psychotic features

Directory of Open Access Journals (Sweden)

George C. Nitzburg

2015-03-01

Conclusions: MSCEIT deficits were found in SSD but not BD− or BD+, suggesting that social cognition may represent an underlying difference between SSD and BD. However, variance in MSCEIT performance among BD patients may also suggest latent BD subgroups characterized by social-cognitive deficits. Findings can help inform future investigations into how social cognition and social brain development differ between SSD and BD.

Umgang mit Open-Access-Publikationsgebühren – die Situation in Deutschland in 2010 [Dealing with open access publication fees – the situation in Germany in 2010

Directory of Open Access Journals (Sweden)

Bandilla, Wolfgang

2012-07-01

über hinaus zeigt der Blick auf die Open-Access-Strategien der Organisationen, dass diese die Transformation von einem subskriptionsbasierten hin zu einem Open-Access-basierten Publikationssystem vorantreiben. Die Ergebnisse der Umfrage machen jedoch auch die Herausforderungen deutlich. Der Beitrag gibt einen Überblick über die Landschaft der Open-Access-Zeitschriften, beschreibt die Aktivitäten und Entwicklungen in den Wissenschaftsorganisationen und stellt die Ergebnisse der Erhebung unter wissenschaftlichen Institutionen in Deutschland vor.

Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders.

Directory of Open Access Journals (Sweden)

Toshio Matsubara

Full Text Available Little is known about disorder-specific biomarkers of bipolar disorder (BD and major depressive disorder (MDD. Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs of individuals with BD, MDD group (17 patients with MDD, 17 FDRs of individuals with MDD, and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT, respectively. The BD group showed a significant main effect of diagnosis in the gray matter (GM volume of the anterior cingulate cortex (ACC; p = 0.01 and left insula (p < 0.01. FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects (p < 0.01, and patients with BD showed significantly smaller ACC (p < 0.01 and left insular GM volume (p < 0.01 than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores (p < 0.05. Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD.

Using theatre to address mental illness stigma: a knowledge translation study in bipolar disorder.

Science.gov (United States)

Michalak, Erin E; Livingston, James D; Maxwell, Victoria; Hole, Rachelle; Hawke, Lisa D; Parikh, Sagar V

2014-01-01

Reduction of the stigma of mental illness is an international priority; arts- and contact-based approaches represent a promising mode of intervention. This project was designed to explore the impact of a one-woman theatrical performance on attitudes towards bipolar disorder (BD) on people with BD and healthcare providers. A playwright and actress who lives with BD developed a stage performance - 'That's Just Crazy Talk' - targeting stigmatizing attitudes towards BD. Prospective, longitudinal and sequential mixed methods were used to assess the impact of the performance on people with BD (n = 80) and healthcare providers (n = 84). Qualitative interviews were conducted with 33 participants (14 people with BD and 19 healthcare providers). Quantitatively, healthcare providers showed significantly improved attitudes immediately post-performance, but this change was not maintained over time; people with BD showed little quantitative change. Qualitatively, both people with BD and BD healthcare providers showed enduring and broadly positive changes. A theatrical presentation designed to reduce stigma produced immediate impact on healthcare providers quantitatively and significant qualitative impact on people with BD and healthcare providers. Additionally, the utility of using mixed-method approaches in mental health research was demonstrated.

Thyroid Autoimmunity and Behçet’s Disease: Is There a Significant Association?

Directory of Open Access Journals (Sweden)

Filiz Cebeci

2013-01-01

Full Text Available Background. Behcet’s disease (BD could be regarded as an autoimmune disease in many aspects. Autoimmune thyroid disease (ATD is frequently accompanied by other various autoimmune diseases. Nevertheless, there is not still enough data showing the association between BD and ATD. In addition, no controlled study is present in the PubMed, which evaluates thyroidal autoimmunity using antithyroid peroxidase antibody in a large series of patients with BD. Methods. We aimed to investigate the frequency of ATD in patients with BD. The study included 124 patients with BD and 99 age- and sex-matched healthy volunteers. Results. Autoimmune thyroiditis was noted in 21 cases (16.9% with BD. In the control group, 22 cases (22.22% were diagnosed as autoimmune thyroiditis. There was no difference between the groups in respect to thyroid autoantibodies (. There were no statistically significant differences between baseline TSH levels of the BD patients and of the controls (. Statistically, the mean serum free T4 levels of the patients with BD were higher than those of the controls (. Conclusions. No association could be found between BD and ATD. Therefore, it is not of significance to investigate thyroid autoimmunity in BD.

Prokaryotic expression of antimicrobial ovine β- defensin-1 in ...

African Journals Online (AJOL)

AJB_YOMI

2011-09-05

Sep 5, 2011 ... 10213. Table 1. PCR primers for amplification of sBD-1, mature (msBD-1) and .... Antimicrobial properties of recombinant psBD-1 and msBD-1 were .... the structure and function of ovispirin/novispirin antimicrobial peptides.

Atomic risk insurance. Risk policy, safety production and expertise in Germany and the USA 1945 - 1986; Die Versicherung der Atomgefahr. Risikopolitik, Sicherheitsproduktion und Expertise in der Bundesrepublik Deutschland und den USA 1945-1986

Energy Technology Data Exchange (ETDEWEB)

Wehner, Christoph [Dokumentations- und Forschungsstelle der Sozialversicherungstraeger, Bochum (Germany)

2017-07-01

The book covers the following chapters: (I) Between threat and promise: Political change and the corporate perception, the burden of the atomic bomb, promise of nuclear energy risk criticism in the pre-ecological phase, nuclear risk as investment restraint; (II) Risk policy at the insurability limit: hazard knowledge, safety production and insurance expertise in the German nuclear policy (1955-1962); (III) Risk policy beyond the catastrophe, insurability interpretation, concepts and conflicts (1957-1968); (IV) Scandalization of risk policy: safety production, confidence and expertise in the nuclear controversial debate (1969 - 1979); (V) Nuclear risk policy and the challenge of the ''risk society'' (1975-1986); (VI) From safety production to hazard probe: atomic energy And the change of insurance.

Lehrer in der Bundesrepublik Deutschland. Eine Kritische Analyse Statistischer Daten uber das Lehrpersonal an Allgemeinbildenden Schulen. (Education in the Federal Republic of Germany. A Statistical Study of Teachers in Schools of General Education.)

Science.gov (United States)

Kohler, Helmut

The purpose of this study was to analyze the available statistics concerning teachers in schools of general education in the Federal Republic of Germany. An analysis of the demographic structure of the pool of full-time teachers showed that in 1971 30 percent of the teachers were under age 30, and 50 percent were under age 35. It was expected that…

Behcet disease combined with Sjogren syndrome: A unique case report and literature review.

Science.gov (United States)

Ju, Fang-He; Xu, Ting-Zhen; Hong, Hui-Hua; Mao, He; Wang, Meng; Wang, Zhen

2018-03-01

Behcet disease(BD) and Sjogren syndrome(SS) are separate conditions that rarely concomitantly affect an individual. In theory,mild symptoms of patients with BD or SS are easy to igore and,thus,remain undiagnosed. There,it is reasonable to believe there may be some clinical cases of combined diseases that go undiscovered and which needs to be taken seriously. In addition,it has been suggested that herpes simplex virus(HSV) types 1 and 2 are associated with BD,but have not been shown to be correlated to the direct pathogenesis of BD. The role of HSV in BD needs more research and attention. Here,we report a young woman who had both BD and SS. The first symptom of the disease was fever. However,the HSV type 1 IgG and HSV type 2 IgM antibody results were positive in our case and,which rendered this case unique. BD and SS concomitantly affect the individual,and BD was the acute type. IV methylprednisolone was used for 9 days and then oral glucocorticoids was used to instead,and the treatment works very well. BD and SS can concomitantly affect an individual,and we believe that HSV-2 may be directly related to the pathogenesis of BD. The nature of BD as an auto-inflammatory disorder, autoimmune disorder, or both, is controversial. If we can find more patients who combined affected these two disease, it might helpful for us to understand the nature of BD. For patients with clinical diagnosis of BD or SS,we need to be alert that it may combinded the other disease. Long term follow up and detailed inspection are important means to avoid undiscovered.

No apparent association between bipolar disorder and cancer in a large epidemiological study of outpatients in a managed care population.

Science.gov (United States)

Kahan, Natan R; Silverman, Barbara; Liphshitz, Irena; Waitman, Dan-Andrei; Ben-Zion, Itzhak; Ponizovsky, Alexander M; Weizman, Abraham; Grinshpoon, Alexander

2018-03-01

An association between bipolar disorder (BD) and cancer risk has been reported. The purpose of this study was to investigate this association through linkage analysis of a national HMO database and a national cancer registry. All members of the Leumit Health Services (LHS) HMO of Israel from 2000 to 2012 were included. Members with a recorded diagnosis of BD and a record of at least one written or dispensed prescription for pharmacotherapy for treatment of BD were classified as patients with BD. We linked the LHS population with the Israel National Cancer Registry database to capture all cases of cancer reported. Standardized incidence ratios (SIRs) for cancer in the BD population as compared with non-BD LHS members were calculated. A total of 870 323 LHS members were included in the analysis; 3304 of whom met the criteria for inclusion in the BD arm. We identified 24 515 and 110 cancer cases among members without BD and with BD, respectively. Persons with BD were no more likely than other HMO members to be diagnosed with cancer during the follow-up period [SIR, males=0.91, 95% confidence interval (CI): 0.66-1.22; SIR, females=1.15, 95% CI: 0.89-1.47]. Sensitivity analysis using different criteria for positive BD classification (lithium treatment alone or registered physician diagnosis) had no effect on the estimate of cancer risk. A nonstatistically significant association between breast cancer and BD among women was observed (SIR=1.24, 95% CI: 0.79-1.86). These findings do not corroborate previously reported associations between BD and elevated cancer risk.

Executive functioning deficits among adults with Bipolar Disorder (types I and II): A systematic review and meta-analysis.

Science.gov (United States)

Dickinson, Tania; Becerra, Rodrigo; Coombes, Jacqui

2017-08-15

Executive functioning (EF) deficits contribute to a significant proportion of the burden of disease associated with bipolar disorder (BD). Yet, there is still debate in the literature regarding the exact profile of executive functioning in BD. The purpose of the present project was to assess whether EF deficits exist among adults suffering BD, and whether these deficits (if apparent) differ by BD subtype. A systematic search identified relevant literature. Randomised controlled trials that used neuropsychological assessment to investigate EF among adults 16-65 years) with a remitted DSM diagnosis of BD (type I or II) were included. Studies were published between 1994 and 2015. A systematic review and meta-analysis were undertaken. For individual studies, standardised mean differences (Cohen's d) and 95% confidence intervals were calculated and represented in forest plots to illustrate differences in executive performance between groups. Summary effects were produced and tests of heterogeneity employed to assess the dispersion and generalisability of results. Thirty-six studies met criteria for inclusion. Six domains of EF were identified: Set-shifting (SS), inhibition (INH), planning (PLA), verbal fluency (VF), working memory (WM), and attention (ATT). BD1s performed worse than HCs in all domains. BD2s demonstrated impairment in VF, WM, SS, and ATT. The results were mixed for comparisons between BD1s and BD2s, but revealed that BD2s can experience similar (or sometimes greater) EF impairment. Only a limited number of studies that included BD2 samples were available for inclusion in the current study. Subgroup analysis to elucidate potential moderators of within-study variance was not undertaken. This is the first systematic review and meta-analysis to have compared the EF of remitted BD1s, BD2s, and HCs. The results provided useful insight into the EF profile of patients with BD, and offered commentary as to some of the contradictory results reported in the

Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach.

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Pessôa, Marco T C; Alves, Silmara L G; Taranto, Alex G; Villar, José A F P; Blanco, Gustavo; Barbosa, Leandro A

2018-12-01

Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzylidene digoxin derivatives) with substitutions in the lactone ring (including non-oxygen and ether groups), to obtain CTS with better NKA isoform specificity. Some of these derivatives show some NKA isoform selective effects, with BD-3, BD-8, and BD-13 increasing NKA α2 activity, BD-5 inhibiting NKA α1 and NKA α3, BD-10 reducing NKA α1, but stimulating NKA α2 and α3; and BD-14, BD-15, and BD-16 enhancing NKA α3 activity. A molecular-docking approach favoured NKA isoform specific interactions for the compounds that supported their observed activity. These results show that BD compounds are a new type of CTS with the capacity to target NKA activity in an isoform-specific manner.

Bipolar disorder comorbidity in patients with a primary diagnosis of OCD.

Science.gov (United States)

Saraf, Gayatri; Paul, Imon; Viswanath, Biju; Narayanaswamy, Janardhanan C; Math, Suresh Bada; Reddy, Y C Janardhan

2017-03-01

Bipolar disorder (BD) is considered to be a common comorbid condition in subjects with obsessive-compulsive disorder (OCD), but there is limited literature on the prevalence of BD and its clinical correlates in those with a primary diagnosis of OCD. We studied the prevalence of BD in a sample of consecutively registered outpatients attending a specialty OCD clinic in India over a period of 13 months. One hundred and seventy-one patients with a primary diagnosis of OCD were assessed systematically using structured and semi-structured instruments. The prevalence of lifetime BD in OCD was 4%. The OCD + BD group had an episodic course of OCD and higher rate of lifetime suicide attempts. BD may not be as highly prevalent in OCD as reported in literature. Those with OCD seem to have only a marginally higher risk for developing BD than the general population. A diagnosis of BD seems to have a pathoplastic effect on the course of OCD. Patients with OCD-BD comorbidity have to be specifically assessed for suicide risk.

Heute Bundes, Gestern Warschau

DEFF Research Database (Denmark)

Wickström, David-Emil

2007-01-01

Durch die Berliner Russendisko ist russische Populärmusik in Deutschland längst kein Geheimtipp mehr. Eines der musikalischen Zentren dieser Musik ist St. Petersburg, dessen aktive Musikszene nie vom aktuellen Musikgeschehen der Welt wirklich abgeschottet war...

Dicty_cDB: SSH467 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available =3 Row=J, DNA sequence. 46 0.68 1 BD265981 |BD265981.1 Schizophrenia associated genes, proteins and bialleli...c markers. 40 0.80 2 BD265980 |BD265980.1 Schizophrenia associated genes, proteins and biallelic markers. 40

Particle Reduction Strategies - PAREST. Emissions in PAREST reference scenario 2005-2020; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Emissionen im PAREST-Referenzszenario 2005-2020

Energy Technology Data Exchange (ETDEWEB)

Joerss, Wolfram [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany); Kugler, Ulrike; Theloke, Jochen [Stuttgart Univ. (Germany). Inst. fuer Energiewirtschaft und Rationelle Energieanwendung (IER)

2013-06-15

In the research project PAREST emission scenarios to 2020 for particulate matter (PM{sub 10} und PM{sub 2,5}), and aerosol precursors SO{sub 2}, NO{sub x}, NH{sub 3} and NMVOC were prepared for Germany and Europe, mitigation measures evaluated and the results used to model the PM pollution load for Germany. In this sub-report of PAREST Germany's aggregate emissions totals of the considered pollutants are presented in the reference scenario. [German] Im Forschungsvorhaben PAREST wurden Emissionsszenarien bis 2020 fuer Feinstaub (PM{sub 10} und PM{sub 2,5}) und die Aerosol-Vorlaeufersubstanzen SO{sub 2}, NO{sub x}, NH{sub 3} und NMVOC fuer Deutschland und Europa erstellt, Minderungsmassnahmen evaluiert und daraus die PM-Immissionsbelastung fuer Deutschland modelliert. In diesem Teilbericht zu PAREST werden die deutschlandweit aggregierten Emissionssummen der betrachteten Schadstoffe im Referenzszenario vorgestellt.

Hybrid Approach for Biliary Interventions Employing MRI-Guided Bile Duct Puncture with Near-Real-Time Imaging

Energy Technology Data Exchange (ETDEWEB)

Wybranski, Christian, E-mail: Christian.Wybranski@uk-koeln.de [University Hospital of Cologne, Department of Diagnostic and Interventional Radiology (Germany); Pech, Maciej [Otto-von-Guericke University Medical School, Department of Radiology and Nuclear Medicine (Germany); Lux, Anke [Otto-von-Guericke University Medical School, Institute of Biometry and Medical Informatics (Germany); Ricke, Jens; Fischbach, Frank; Fischbach, Katharina [Otto-von-Guericke University Medical School, Department of Radiology and Nuclear Medicine (Germany)

2017-06-15

ObjectiveTo assess the feasibility of a hybrid approach employing MRI-guided bile duct (BD) puncture for subsequent fluoroscopy-guided biliary interventions in patients with non-dilated (≤3 mm) or dilated BD (≥3 mm) but unfavorable conditions for ultrasonography (US)-guided BD puncture.MethodsA total of 23 hybrid interventions were performed in 21 patients. Visualization of BD and puncture needles (PN) in the interventional MR images was rated on a 5-point Likert scale by two radiologists. Technical success, planning time, BD puncture time and positioning adjustments of the PN as well as technical success of the biliary intervention and complication rate were recorded.ResultsVisualization even of third-order non-dilated BD and PN was rated excellent by both radiologists with good to excellent interrater agreement. MRI-guided BD puncture was successful in all cases. Planning and BD puncture times were 1:36 ± 2.13 (0:16–11:07) min. and 3:58 ± 2:35 (1:11–9:32) min. Positioning adjustments of the PN was necessary in two patients. Repeated capsular puncture was not necessary in any case. All biliary interventions were completed successfully without major complications.ConclusionA hybrid approach which employs MRI-guided BD puncture for subsequent fluoroscopy-guided biliary intervention is feasible in clinical routine and yields high technical success in patients with non-dilated BD and/or unfavorable conditions for US-guided puncture. Excellent visualization of BD and PN in near-real-time interventional MRI allows successful cannulation of the BD.

Exciplex formation and excited state deactivation of difluoroborondipyrromethene (Bodipy) dyads.

Science.gov (United States)

Benniston, Andrew C; Copley, Graeme; Lemmetyinen, Helge; Tkachenko, Nikolai V

2010-06-07

Two series of geometrically-related dyads are discussed based on the difluoroborondipyrromethene (Bodipy) unit, and incorporating covalently attached hydroquinone/quinone groups. These units are anchored directly, or via a phenylene spacer, to the Bodipy core at the meso position in one series (BD-MHQ, BD-MQ, BD-MPHQ, BD-MPQ), but for the second series the attachment site is the 2-position (BD-SHQ, BD-SQ, BD-SPHQ, BD-SPQ). The compounds show various levels of fluorescence depending on the oxidation state of the appended group and the substitution pattern. In non-polar solvents such as toluene, diethyl ether and dichlorobenzene, the S(1) state deactivation of the Bodipy unit in BD-SPQ and BD-MPQ is dominated by (1, 3)exciplex formation, which has not been reported for Bodipy derivatives so far. In the latter molecule, the decay of the exciplex is divided between population of the Bodipy triplet state (13 %-21 %) and ground state reformation. This partitioning is not seen for the side-on substituted derivative, BD-SPQ, and only ground state reformation is observed following decay of the exciplex. This difference in behavior is explained by the radical-pair inter-system-crossing mechanism, which more effectively operates in BD-MPQ because of the orthogonality of the donor-acceptor units. In the more polar solvent CH(3)CN all the quinone derivatives show fast formation of the charge-separated state (k(CS)) followed by slower charge recombination (k(CR)). The ratio k(CS)/k(CR)

Distinguishing between unipolar depression and bipolar depression: current and future clinical and neuroimaging perspectives.

Science.gov (United States)

Cardoso de Almeida, Jorge Renner; Phillips, Mary Louise

2013-01-15

Differentiating bipolar disorder (BD) from recurrent unipolar depression (UD) is a major clinical challenge. Main reasons for this include the higher prevalence of depressive relative to hypo/manic symptoms during the course of BD illness and the high prevalence of subthreshold manic symptoms in both BD and UD depression. Identifying objective markers of BD might help improve accuracy in differentiating between BD and UD depression, to ultimately optimize clinical and functional outcome for all depressed individuals. Yet, only eight neuroimaging studies to date have directly compared UD and BD depressed individuals. Findings from these studies suggest more widespread abnormalities in white matter connectivity and white matter hyperintensities in BD than UD depression, habenula volume reductions in BD but not UD depression, and differential patterns of functional abnormalities in emotion regulation and attentional control neural circuitry in the two depression types. These findings suggest different pathophysiologic processes, especially in emotion regulation, reward, and attentional control neural circuitry in BD versus UD depression. This review thereby serves as a call to action to highlight the pressing need for more neuroimaging studies, using larger samples sizes, comparing BD and UD depressed individuals. These future studies should also include dimensional approaches, studies of at-risk individuals, and more novel neuroimaging approaches, such as connectivity analysis and machine learning. Ultimately, these approaches might provide biomarkers to identify individuals at future risk for BD versus UD and biological targets for more personalized treatment and new treatment developments for BD and UD depression. Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Dicty_cDB: AFO448 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available of isoprenoid content, compostition and metabolism. 54 0.004 1 BD224357 |BD224357.1 Materials and methods fo...SSA008C03 : 5' end, single read. 50 0.002 2 BD272997 |BD272997.1 Materials and methods for the modification

Consequences of observed Bd-anti Bd mixing in standard and nonstandard models

International Nuclear Information System (INIS)

Datta, A.; Paschos, E.A.; Tuerke, U.

1987-01-01

Implications of the B d -anti B d mixing report by the ARGUS group are investigated. We show that in order for the standard model to accomodate the result, the B → anti B hadronic matrix element must satisfy lower bounds as a function of top quark mass. In this case B S -anti B S mixing is necessarily large (r S > or approx. 0.74) irrespective of m t . This conclusion remains valid in several popular extensions of the standard model with three generations. In contrast to these models, four generation models can accomodate simultaneously the observed B d -anti B d mixing and a relatively small B S -anti B S mixing. (orig.)

Relationship between personality disorder functioning styles and the emotional states in bipolar I and II disorders.

Directory of Open Access Journals (Sweden)

Jiashu Yao

Full Text Available Bipolar disorder types I (BD I and II (BD II behave differently in clinical manifestations, normal personality traits, responses to pharmacotherapies, biochemical backgrounds and neuroimaging activations. How the varied emotional states of BD I and II are related to the comorbid personality disorders remains to be settled.We therefore administered the Plutchick - van Praag Depression Inventory (PVP, the Mood Disorder Questionnaire (MDQ, the Hypomanic Checklist-32 (HCL-32, and the Parker Personality Measure (PERM in 37 patients with BD I, 34 BD II, and in 76 healthy volunteers.Compared to the healthy volunteers, patients with BD I and II scored higher on some PERM styles, PVP, MDQ and HCL-32 scales. In BD I, the PERM Borderline style predicted the PVP scale; and Antisocial predicted HCL-32. In BD II, Borderline, Dependent, Paranoid (- and Schizoid (- predicted PVP; Borderline predicted MDQ; Passive-Aggressive and Schizoid (- predicted HCL-32. In controls, Borderline and Narcissistic (- predicted PVP; Borderline and Dependent (- predicted MDQ.Besides confirming the different predictability of the 11 functioning styles of personality disorder to BD I and II, we found that the prediction was more common in BD II, which might underlie its higher risk of suicide and poorer treatment outcome.

Progranulin gene variability influences the risk for bipolar I disorder, but not bipolar II disorder.

Science.gov (United States)

Galimberti, Daniela; Prunas, Cecilia; Paoli, Riccardo A; Dell'Osso, Bernardo; Fenoglio, Chiara; Villa, Chiara; Palazzo, Carlotta; Cigliobianco, Michela; Camuri, Giulia; Serpente, Maria; Scarpini, Elio; Altamura, A Carlo

2014-11-01

Recent data have shown that genetic variability in the progranulin (GRN) gene may contribute to the susceptibility to developing bipolar disorder (BD). However, in regard to patients with BD, no information is available on the role of genetic variability and plasma progranulin levels in different types of this disorder. In this study, we performed an association analysis of GRN in an Italian population consisting of 134 patients with BD and 232 controls to evaluate progranulin plasma levels. The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD-I) (odds ratio = 0.55, 95% confidence interval: 0.33-0.93; p = 0.024) but not bipolar II disorder (BD-II) (p > 0.05). In addition, plasma progranulin levels are significantly decreased in BD [mean ± standard deviation (SD) 112 ± 35 versus 183 ± 93 ng/mL in controls; p < 0.001]. Regarding the influence of GRN variability on BD susceptibility, the predisposing genetic background differs between BD-I and BD-II, possibly implying that pathogenic mechanisms differ between the two subtypes of BD. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder.

Science.gov (United States)

Marshall, David F; Walker, Sara J; Ryan, Kelly A; Kamali, Masoud; Saunders, Erika F H; Weldon, Anne L; Adams, Kenneth M; McInnis, Melvin G; Langenecker, Scott A

2012-12-30

Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses. Published by Elsevier Ireland Ltd.

Burden of maternal bipolar disorder on at-risk offspring: a controlled study on family planning and maternal care.

Science.gov (United States)

Moreno, Doris Hupfeld; Bio, Danielle Soares; Petresco, Sandra; Petresco, Denise; Gutt, Elisa Kijner; Soeiro-de-Souza, Márcio Gerhardt; Moreno, Ricardo Alberto

2012-12-20

Bipolar disorder (BD) is a highly incapacitating disease typically associated with high rates of familial dysfunction. Despite recent literature suggesting that maternal care is an important environmental factor in the development of behavioral disorders, it is unclear how much maternal care is dysfunctional in BD subjects. The objective of this study was to characterize maternal care in DSM-IV/SCID diagnosed BD type I subjects compared to healthy controls with (PD) and without (NPD) other psychiatric diagnoses. Thirty-four BD mothers and 106 controls underwent an interview about family planning and maternal care, obstetrical complications, and mother-child interactions. K-SADS-PL questions about violence exposure were used to ascertain domestic violence and physical/sexual abuse. BD mothers were less likely to have stable unions (45.5%; pmothers. Due to BD mothers' symptoms, 33.3% of offspring suffered physical and/or psychological abuse. Post hoc analysis, and the use of questions as a surrogate of symptoms as opposed to validated instruments. This is one of few reports confirming that maternal care given by BD women is dysfunctional. BD psychopathology can lead to poor maternal care and both should be considered important environmental risk factors in BD, suggesting that BD psychoeducation should include maternal care orientation. Copyright © 2012 Elsevier B.V. All rights reserved.

Relationship between Personality Disorder Functioning Styles and the Emotional States in Bipolar I and II Disorders

Science.gov (United States)

Yao, Jiashu; Xu, You; Qin, Yanhua; Liu, Jing; Shen, Yuedi; Wang, Wei; Chen, Wei

2015-01-01

Background Bipolar disorder types I (BD I) and II (BD II) behave differently in clinical manifestations, normal personality traits, responses to pharmacotherapies, biochemical backgrounds and neuroimaging activations. How the varied emotional states of BD I and II are related to the comorbid personality disorders remains to be settled. Methods We therefore administered the Plutchick – van Praag Depression Inventory (PVP), the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32), and the Parker Personality Measure (PERM) in 37 patients with BD I, 34 BD II, and in 76 healthy volunteers. Results Compared to the healthy volunteers, patients with BD I and II scored higher on some PERM styles, PVP, MDQ and HCL-32 scales. In BD I, the PERM Borderline style predicted the PVP scale; and Antisocial predicted HCL-32. In BD II, Borderline, Dependant, Paranoid (-) and Schizoid (-) predicted PVP; Borderline predicted MDQ; Passive-Aggressive and Schizoid (-) predicted HCL-32. In controls, Borderline and Narcissistic (-) predicted PVP; Borderline and Dependant (-) predicted MDQ. Conclusion Besides confirming the different predictability of the 11 functioning styles of personality disorder to BD I and II, we found that the prediction was more common in BD II, which might underlie its higher risk of suicide and poorer treatment outcome. PMID:25625553

In silico aided metabolic engineering of Klebsiella oxytoca and fermentation optimization for enhanced 2,3-butanediol production.

Science.gov (United States)

Park, Jong Myoung; Song, Hyohak; Lee, Hee Jong; Seung, Doyoung

2013-09-01

Klebsiella oxytoca naturally produces a large amount of 2,3-butanediol (2,3-BD), a promising bulk chemical with wide industrial applications, along with various byproducts. In this study, the in silico gene knockout simulation of K. oxytoca was carried out for 2,3-BD overproduction by inhibiting the formation of byproducts. The knockouts of ldhA and pflB genes were targeted with the criteria of maximization of 2,3-BD production and minimization of byproducts formation. The constructed K. oxytoca ΔldhA ΔpflB strain showed higher 2,3-BD yields and higher final concentrations than those obtained from the wild-type and ΔldhA strains. However, the simultaneous deletion of both genes caused about a 50 % reduction in 2,3-BD productivity compared with K. oxytoca ΔldhA strain. Based on previous studies and in silico investigation that the agitation speed during 2,3-BD fermentation strongly affected cell growth and 2,3-BD synthesis, the effect of agitation speed on 2,3-BD production was investigated from 150 to 450 rpm in 5-L bioreactors containing 3-L culture media. The highest 2,3-BD productivity (2.7 g/L/h) was obtained at 450 rpm in batch fermentation. Considering the inhibition of acetoin for 2,3-BD production, fed-batch fermentations were performed using K. oxytoca ΔldhA ΔpflB strain to enhance 2,3-BD production. Altering the agitation speed from 450 to 350 rpm at nearly 10 g/L of acetoin during the fed-batch fermentation allowed for the production of 113 g/L 2,3-BD, with a yield of 0.45 g/g, and for the production of 2.1 g/L/h of 2,3-BD.

Assessment of the hepatitis B birth dose vaccination program, Papua New Guinea, 2014.

Science.gov (United States)

Wiesen, Eric; Lagani, William; Sui, Gerard; Arava, Johnnie; Reza, Salim; Diorditsa, Sergey; Lin, Yung-Ching

2016-01-12

Papua New Guinea (PNG) implemented hepatitis B birth dose (BD) vaccination in 2005 yet since that time coverage has remained low, allowing mother-to-child transmission to occur. We conducted a field assessment of the BD vaccination program to develop strategies for improving the BD coverage. We selected five provinces with higher hepatitis B prevalence and five with lower prevalence based on the results of a 2013 hepatitis B serological survey. Within each province, we interviewed district and provincial health officers, health workers, village volunteers, and caregivers from ten randomly selected health facilities. Data were collected on knowledge, practice, vaccine management and data recording/reporting. To identify enabling factors and barriers, we compared health facilities with higher BD coverage with those with lower coverage, and compared caregivers whose children received BD with those whose children did not. Overall timely BD coverage was 31% and BD vaccination was taking place in 81% of sampled health facilities. Lack of cold chain and vaccine were the major reasons for not providing the BD. Insufficiencies in supervision, vaccine management, community outreach, and data management were identified as obstacles to achieving high timely hepatitis B BD coverage. Good supervision, knowledge of hepatitis B and hepatitis B vaccination, antenatal care including information about the hepatitis B BD, provision of vaccine refrigerators in maternity wards, and outreach vaccination for home deliveries were associated with higher timely BD coverage. Several steps will likely be effective in improving BD coverage: strengthening training and supervision among health workers and officers, educating caregivers on the benefits of the BD and delivery in health facilities, improving vaccine management, and improving data quality. Considerable effort and leadership will be needed to achieve these steps. Copyright © 2015. Published by Elsevier Ltd.

Impulse oscillometry at preschool age is a strong predictor of lung function by flow-volume spirometry in adolescence.

Science.gov (United States)

Lauhkonen, Eero; Riikonen, Riikka; Törmänen, Sari; Koponen, Petri; Nuolivirta, Kirsi; Helminen, Merja; Toikka, Jyri; Korppi, Matti

2018-05-01

The transition from early childhood wheezing to persistent asthma is linked to lung function impairment over time. Little is known how the methods used to study lung function at different ages correlate longitudinally. Sixty-four children with a history of hospitalization for bronchiolitis before 6 months of age were prospectively studied with impulse oscillometry (IOS) at the mean age of 6.3 years and these preschool IOS results were compared with flow-volume spirometry (FVS) measurements at mean age of 11.4 years. The baseline respiratory system resistance at 5 Hz (Rrs5) showed a modest statistically significant correlation with all baseline FVS parameters except FVC. The post-bronchodilator (post-BD) Rrs5 showed a modest statistically significant correlation with post-BD FEV 1 and FEV 1 /FVC. The bronchodilator-induced decrease in Rrs5 showed a modest statistically significant correlation with the percent increase in FEV 1 . Baseline and post-BD respiratory reactance at 5 Hz (Xrs5) showed a modest statistically significant correlation with baseline and post-BD FVS parameters except post-BD FEV 1 /FVC, respectively, and post-BD Xrs5 showed a strong correlation with post-BD FVC (ρ = 0.61) and post-BD FEV 1 (ρ = 0.59). In adjusted linear regression, preschool Xrs5 remained as a statistically significant independent predictor of FVS parameters in adolescence; the one-unit decrease in the Z-score of preschool post-BD Xrs5 predicted 9.6% lower post-BD FEV 1 , 9.3% lower post-BD FVC, and 9.7% lower post-BD MEF 50 when expressed as %-predicted parameters. Persistent post-BD small airway impairment in children with a history of bronchiolitis detected with IOS at preschool age predicted FVS results measured in early adolescence. © 2018 Wiley Periodicals, Inc.

Distinguishing between Unipolar Depression and Bipolar Depression: Current and Future Clinical and Neuroimaging Perspectives

OpenAIRE

de Almeida, Jorge Renner Cardoso; Phillips, Mary Louise

2012-01-01

Differentiating bipolar disorder (BD) from recurrent unipolar depression (UD) is a major clinical challenge. Main reasons for this include the higher prevalence of depressive relative to hypo/manic symptoms during the course of BD illness and the high prevalence of subthreshold manic symptoms in both BD and UD depression. Identifying objective markers of BD might help improve accuracy in differentiating between BD and UD depression, to ultimately optimize clinical and functional outcome for a...

Analysis of Th Cell-related Cytokine Production in Behçet Disease Patients with Uveitis Before and After Infliximab Treatment.

Science.gov (United States)

Takeuchi, Masaru; Karasawa, Yoko; Harimoto, Kohzou; Tanaka, Atsushi; Shibata, Masaki; Sato, Tomohito; Caspi, Rachel R; Ito, Masataka

2017-02-01

To examine antigen-stimulated cytokine production by Behçet disease patients (BD) before and after infliximab infusion. PBMCs were obtained before and after infliximab infusion in BD patients with or without recurrent uveitis during at least 1 year of infliximab therapy, and from healthy subjects. PBMCs were cultured with IRBP, and Th-related cytokines in cultures were measured. Levels of IL-4, IL-6, IL-10 IL-17A, IL-17F, IL-31, IFN-γ, and TNFα were higher in BD before infliximab infusion than in healthy subjects, and these levels were the highest in BD with recurrent uveitis. After infliximab infusion, these cytokine levels were reduced to a greater extent in BD without recurrent uveitis than in BD with recurrence. Th-related cytokines produced by IRBP-stimulated PBMCs were elevated in BD, and infliximab infusion suppressed these cytokines to a greater extent in BD without recurrent uveitis than in those with recurrence.

Genetic Association of , and - with Behcet's Disease in Saudi Patients

Directory of Open Access Journals (Sweden)

Fahda Al-Okaily

2016-01-01

Full Text Available Background HLA-B*51 has been universally associated with Behcet's disease (BD susceptibility, while different alleles of HLA-A have also been identified as independent BD susceptibility loci in various ethnic populations. The objective of this study was to investigate associations of HLA-A and - B alleles with BD in Saudi patients. Materials and Methods Genotyping for HLA-A and HLA-B was performed using HLA genotyping kit (Lab type (R SSO in 120 Saudi subjects, including 60 BD patients and 60 matched healthy controls. Results Our results revealed that frequencies of HLA-A*26, -A*31 , and - B*51 were significantly higher in BD patients than in controls, suggesting that HLA-A*26, -A*31 , and - B*51 are associated with BD. The frequency of HLA-B*15 was significantly lower in BD patients than in controls. Stratification of genotyping results into active and nonactive forms of BD revealed that the frequency of HLA-A*31 was significantly higher in the nonactive form than in the active form of BD, while there was no significant difference in the distribution of other alleles between the two forms of BD. Conclusion This study suggests that HLA-A*26, -A*31 , and - B*51 are associated with susceptibility risk to BD, while HLA-B*15 may be protective in Saudi patients. However, larger scale studies are needed to confirm these findings.

Expression and new exon mutations of the human Beta defensins and their association on colon cancer development.

Directory of Open Access Journals (Sweden)

Abdelhabib Semlali

Full Text Available The development of cancer involves genetic predisposition and a variety of environmental exposures. Genome-wide linkage analyses provide evidence for the significant linkage of many diseases to susceptibility loci on chromosome 8p23, the location of the human defensin gene cluster. Human β-defensins (hBDs are important molecules of innate immunity. This study was designed to analyze the expression and genetic variations in hBDs (hBD-1, hBD-2, hBD-3 and hBD-4 and their putative association with colon cancer. hBD gene expression and relative protein expression were evaluated by Real-Time polymerase chain reaction (qPCR and immunohistochemistry, respectively, from 40 normal patients and 40 age-matched patients with colon cancer in Saudi Arabia. In addition, hBD polymorphisms were genotyped by exon sequencing and by promoter methylation. hBD-1, hBD-2, hBD-3 and hBD-4 basal messenger RNA expression was significantly lower in tumor tissues compared with normal tissues. Several insertion mutations were detected in different exons of the analyzed hBDs. However, no methylation in any hBDs promoters was detected because of the limited number of CpG islands in these regions. We demonstrated for the first time a link between hBD expression and colon cancer. This suggests that there is a significant link between innate immunity deregulation through disruption of cationic peptides (hBDs and the potential development of colon cancer.

Cool temperatures reduce antifungal activity of symbiotic bacteria of threatened amphibians--implications for disease management and patterns of decline.

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Joshua H Daskin

Full Text Available Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd, is a widespread disease of amphibians responsible for population declines and extinctions. Some bacteria from amphibians' skins produce antimicrobial substances active against Bd. Supplementing populations of these cutaneous antifungal bacteria might help manage chytridiomycosis in wild amphibians. However, the activity of protective bacteria may depend upon environmental conditions. Biocontrol of Bd in nature thus requires knowledge of how environmental conditions affect their anti-Bd activity. For example, Bd-driven amphibian declines have often occurred at temperatures below Bd's optimum range. It is possible these declines occurred due to reduced anti-Bd activity of bacterial symbionts at cool temperatures. Better understanding of the effects of temperature on chytridiomycosis development could also improve risk evaluation for amphibian populations yet to encounter Bd. We characterized, at a range of temperatures approximating natural seasonal variation, the anti-Bd activity of bacterial symbionts from the skins of three species of rainforest tree frogs (Litoria nannotis, Litoria rheocola, and Litoria serrata. All three species declined during chytridiomycosis outbreaks in the late 1980s and early 1990s and have subsequently recovered to differing extents. We collected anti-Bd bacterial symbionts from frogs and cultured the bacteria at constant temperatures from 8 °C to 33 °C. Using a spectrophotometric assay, we monitored Bd growth in cell-free supernatants (CFSs from each temperature treatment. CFSs from 11 of 24 bacteria showed reduced anti-Bd activity in vitro when they were produced at cool temperatures similar to those encountered by the host species during population declines. Reduced anti-Bd activity of metabolites produced at low temperatures may, therefore, partially explain the association between Bd-driven declines and cool temperatures. We show that to

Cool temperatures reduce antifungal activity of symbiotic bacteria of threatened amphibians--implications for disease management and patterns of decline.

Science.gov (United States)

Daskin, Joshua H; Bell, Sara C; Schwarzkopf, Lin; Alford, Ross A

2014-01-01

Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a widespread disease of amphibians responsible for population declines and extinctions. Some bacteria from amphibians' skins produce antimicrobial substances active against Bd. Supplementing populations of these cutaneous antifungal bacteria might help manage chytridiomycosis in wild amphibians. However, the activity of protective bacteria may depend upon environmental conditions. Biocontrol of Bd in nature thus requires knowledge of how environmental conditions affect their anti-Bd activity. For example, Bd-driven amphibian declines have often occurred at temperatures below Bd's optimum range. It is possible these declines occurred due to reduced anti-Bd activity of bacterial symbionts at cool temperatures. Better understanding of the effects of temperature on chytridiomycosis development could also improve risk evaluation for amphibian populations yet to encounter Bd. We characterized, at a range of temperatures approximating natural seasonal variation, the anti-Bd activity of bacterial symbionts from the skins of three species of rainforest tree frogs (Litoria nannotis, Litoria rheocola, and Litoria serrata). All three species declined during chytridiomycosis outbreaks in the late 1980s and early 1990s and have subsequently recovered to differing extents. We collected anti-Bd bacterial symbionts from frogs and cultured the bacteria at constant temperatures from 8 °C to 33 °C. Using a spectrophotometric assay, we monitored Bd growth in cell-free supernatants (CFSs) from each temperature treatment. CFSs from 11 of 24 bacteria showed reduced anti-Bd activity in vitro when they were produced at cool temperatures similar to those encountered by the host species during population declines. Reduced anti-Bd activity of metabolites produced at low temperatures may, therefore, partially explain the association between Bd-driven declines and cool temperatures. We show that to avoid

Fungal infection intensity and zoospore output of Atelopus zeteki, a potential acute chytrid supershedder.

Directory of Open Access Journals (Sweden)

Graziella V Direnzo

Full Text Available Amphibians vary in their response to infection by the amphibian-killing chytrid fungus, Batrachochytrium dendrobatidis (Bd. Highly susceptible species are the first to decline and/or disappear once Bd arrives at a site. These competent hosts likely facilitate Bd proliferation because of ineffective innate and/or acquired immune defenses. We show that Atelopus zeteki, a highly susceptible species that has undergone substantial population declines throughout its range, rapidly and exponentially increases skin Bd infection intensity, achieving intensities that are several orders of magnitude greater than most other species reported. We experimentally infected individuals that were never exposed to Bd (n = 5 or previously exposed to an attenuated Bd strain (JEL427-P39; n = 3. Within seven days post-inoculation, the average Bd infection intensity was 18,213 zoospores (SE: 9,010; range: 0 to 66,928. Both average Bd infection intensity and zoospore output (i.e., the number of zoospores released per minute by an infected individual increased exponentially until time of death (t50 = 7.018, p<0.001, t46 = 3.164, p = 0.001, respectively. Mean Bd infection intensity and zoospore output at death were 4,334,422 zoospores (SE: 1,236,431 and 23.55 zoospores per minute (SE: 22.78, respectively, with as many as 9,584,158 zoospores on a single individual. The daily percent increases in Bd infection intensity and zoospore output were 35.4% (SE: 0.05 and 13.1% (SE: 0.04, respectively. We also found that Bd infection intensity and zoospore output were positively correlated (t43 = 3.926, p<0.001. All animals died between 22 and 33 days post-inoculation (mean: 28.88; SE: 1.58. Prior Bd infection had no effect on survival, Bd infection intensity, or zoospore output. We conclude that A. zeteki, a highly susceptible amphibian species, may be an acute supershedder. Our results can inform epidemiological models to estimate Bd outbreak probability, especially as they relate

What is bizarre in bizarre delusions? A critical review

DEFF Research Database (Denmark)

Cermolacce, Michel René Joseph; Jensen, Lars Meldgaard Sass; Parnas, J

2010-01-01

. These studies provide highly heterogenous results because they are based on different experimental paradigms, in terms of definition, clinical sample, and number of raters. Here, we first discuss the psychopathological sources of the concept of BD, which were initially described as either nonsensical...... or incomprehensible. Then, we provide a critical review of contemporary studies on the reliability of BD and their methodological and conceptual limitations. Current approaches have focused intensely on BD's reliability and have defined BD strictly in terms of delusional content--mainly in terms of the physical...... impossibility or the cultural or historical incomprehensibility of the delusional claims. These approaches have neglected formal features of experience that underlie BD and the crucial issue of the nature and validity of BD. In the discussion, we argue that clinical diagnosis of BD cannot be limited...

Berliinis räägiti NordStreami venimisest / Raavo Raadik

Index Scriptorium Estoniae

Raadik, Raavo

2008-01-01

Financial Times Deutschland (FTD) ajakirjanikud vahendasid Vene gaasikontserni Gazprom juhatuse liikme Valeri Jassevi kinnitusi, et gaasijuhtme esimene osa peaks valmima 2011. aastal ja 2012. aastal peaks algama esimesed gaasitarned. Seni oli NordStream lähtunud varasematest tähtaegadest

Die DDR zwischen Einheit und Abgrenzung : Höhepunkte aus der deutschen Geschichte als Paradigmen politischen Wandels : Luther, Friedrich II. und Bismarck

NARCIS (Netherlands)

Brinks, Jan Herman

1991-01-01

Im Jahre 1945 befand sich die Geschichte Deutschlands, darin besteht Konsens unter Historikern aller Richtungen, an einem ihrer tiefgreifendsten Wendepunkte. Die Ereignissein Hiroshima und in Potsdam im Sommer jenes Jahres, so urteilt Werner Conze, markieren einschneidenste Zäsuren der europdischen,

cognitio dei et nostri

African Journals Online (AJOL)

Dr. Wilhelm H. Neuser DD, emeritus, Buchenstraße 15, D-48346 Ostbevern,. Deutschland. ... Calvin, J., Institutes of the Christian Religion 1536, transl. by F.L. Battles, Grand. Rapids, 1986, 15-18. ..... und Leben, und es gibt keine andere Weis-.

Populism või normaliseerumine? / Jeroen Bult

Index Scriptorium Estoniae

Bult, Jeroen

2010-01-01

Autor leiab, et Saksamaa kõrge riigiametniku Thilo Sarrazini raamat "Deutschland schafft sich ab. Wie wir unser Land aufs Spiel setzen", milles ta kritiseerib islamiusulisi sisserändajaid, võiks algatada rahvusliku debati: millist laadi immigrante on vananeva elanikkonnaga Saksamaale vaja

Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention

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Allyson L. Dir

2017-12-01

Full Text Available Alcohol use, particularly binge drinking (BD, is a major public health concern among adolescents. Recent national data show that the gender gap in alcohol use is lessening, and BD among girls is rising. Considering the increase in BD among adolescent girls, as well as females’ increased risk of experiencing more severe biopsychosocial negative effects and consequences from BD, the current review sought to examine gender differences in risk factors for BD. The review highlights gender differences in (1 developmental-related neurobiological vulnerability to BD, (2 psychiatric comorbidity and risk phenotypes for BD, and (3 social-related risk factors for BD among adolescents, as well as considerations for BD prevention and intervention. Most of the information gleaned thus far has come from preclinical research. However, it is expected that, with recent advances in clinical imaging technology, neurobiological effects observed in lower mammals will be confirmed in humans and vice versa. A synthesis of the literature highlights that males and females experience unique neurobiological paths of development, and although there is debate regarding the specific nature of these differences, literature suggests that these differences in turn influence gender differences in psychiatric comorbidity and risk for BD. For one, girls are more susceptible to stress, depression, and other internalizing behaviors and, in turn, these symptoms contribute to their risk for BD. On the other hand, males, given gender differences across the lifespan as well as gender differences in development, are driven by an externalizing phenotype for risk of BD, in part, due to unique paths of neurobiological development that occur across adolescence. With respect to social domains, although social and peer influences are important for both adolescent males and females, there are gender differences. For example, girls may be more sensitive to pressure from peers to fit in and

The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information.

Science.gov (United States)

Dima, Danai; de Jong, Simone; Breen, Gerome; Frangou, Sophia

2016-01-01

Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD). Several risk-conferring SNPs have been individually shown to influence regional brain activation thus linking genetic risk for BD to altered brain function. The current study examined whether the polygenic risk score method, which models the cumulative load of all known risk-conferring SNPs, may be useful in the identification of brain regions whose function may be related to the polygenic architecture of BD. We calculated the individual polygenic risk score for BD (PGR-BD) in forty-one patients with the disorder, twenty-five unaffected first-degree relatives and forty-six unrelated healthy controls using the most recent Psychiatric Genomics Consortium data. Functional magnetic resonance imaging was used to define task-related brain activation patterns in response to facial affect and working memory processing. We found significant effects of the PGR-BD score on task-related activation irrespective of diagnostic group. There was a negative association between the PGR-BD score and activation in the visual association cortex during facial affect processing. In contrast, the PGR-BD score was associated with failure to deactivate the ventromedial prefrontal region of the default mode network during working memory processing. These results are consistent with the threshold-liability model of BD, and demonstrate the usefulness of the PGR-BD score in identifying brain functional alternations associated with vulnerability to BD. Additionally, our findings suggest that the polygenic architecture of BD is not regionally confined but impacts on the task-dependent recruitment of multiple brain regions.

Bipolar II disorder as a risk factor for postpartum depression.

Science.gov (United States)

Mandelli, Laura; Souery, Daniel; Bartova, Lucie; Kasper, Siegfried; Montgomery, Stuart; Zohar, Joseph; Mendlewicz, Julien; Serretti, Alessandro

2016-11-01

There is evidence for a bipolar diathesis in postpartum depression (PPD) and women presenting with a first PPD frequently receive a diagnosis of bipolar type II disorder (BD-II). However formal evidence for an association between BD-II and PPD has not yet been reported. In the present study we tested a potential association between BD-II and PPD. Parous women with a diagnosis of bipolar type I disorder (BD-I) (n=93), BD-II (n=36) or major depressive disorder (MDD) (n=444) were considered in the present study. All women were retrospectively evaluated for history of PPD (DSM-IV criteria) and other clinical and socio-demographic features. Women with a history of PDD (n=139, 24%) were younger, younger at illness onset and had more family history for BD compared to women without history of PPD (n=436, 75.9%). Half of BD-II women reported PPD (50%), compared to less than one-third of BD-I and MDD women (respectively 27.5% and 21.6%) (p=0.004). Limitations include the retrospective assessment of PPD and no available data about the timing of postpartum episodes, illness onset or psychiatric care before or after childbirth, and the number of postpartum episodes. BD-II may confer a remarkable risk for PPD, which may be even higher than that of women affected by BD-I disorder. Careful monitoring of BD-II women during the pregnancy and postpartum period, as well as assessment of bipolar features in women with a PPD without a current diagnosis of BD are recommended. Copyright © 2016 Elsevier B.V. All rights reserved.

Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations.

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Bradley, Paul W; Gervasi, Stephanie S; Hua, Jessica; Cothran, Rickey D; Relyea, Rick A; Olson, Deanna H; Blaustein, Andrew R

2015-10-01

Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However, there is little information on whether sensitivity to Bd differs among populations, which is essential for understanding Bd-infection dynamics and for formulating conservation strategies. We experimentally investigated intraspecific differences in host sensitivity to Bd across 10 populations of wood frogs (Lithobates sylvaticus) raised from eggs to metamorphosis. We exposed the post-metamorphic wood frogs to Bd and monitored survival for 30 days under controlled laboratory conditions. Populations differed in overall survival and mortality rate. Infection load also differed among populations but was not correlated with population differences in risk of mortality. Such population-level variation in sensitivity to Bd may result in reservoir populations that may be a source for the transmission of Bd to other sensitive populations or species. Alternatively, remnant populations that are less sensitive to Bd could serve as sources for recolonization after epidemic events. © 2015 Society for Conservation Biology.

Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder

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Sonja M. C. de Zwarte

2014-03-01

Full Text Available Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD. Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM in the pathophysiology of BD. This review discusses evidence for the involvement of abnormal WM development in BD during adolescence, with a focus on frontotemporal WM. Findings from diffusion tensor imaging (DTI studies in adults and adolescents are reviewed to explore possible progressive WM abnormalities in the disorder. Intra- and interhemispheric frontotemporal abnormalities were reported in adults with BD. Although evidence in children and adolescents with BD to date has been limited, similar intrahemispheric and interhemispheric findings have also been reported. The findings in youths suggest that these abnormalities may represent a trait marker present early in the course of BD. Functional connectivity studies, demonstrating a relationship between WM abnormalities and frontotemporal dysfunction in BD, and DTI studies of vulnerability in first-degree relatives of individuals with BD, are discussed. Together, findings suggest the involvement of abnormal frontotemporal WM development in the pathophysiology of BD and that these abnormalities may be early trait markers of vulnerability; however, more studies are critically needed.

Distribution limits of Batrachochytrium dendrobatidis: a case study in the Rocky Mountains, USA

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Hossack, Blake R.; Muths, Erin L.; Anderson, Chauncey W.; Kirshtein, Julie D.; Corn, P. Stephen

2009-01-01

Knowledge of the environmental constraints on a pathogen is critical to predicting its dynamics and effects on populations. Batrachochytrium dendrobatidis (Bd), an aquatic fungus that has been linked with widespread amphibian declines, is ubiquitous in the Rocky Mountains. As part of assessing the distribution limits of Bd in our study area, we sampled the water column and sediments for Bd zoospores in 30 high-elevation water bodies that lacked amphibians. All water bodies were in areas where Bd has been documented from neighboring, lower-elevation areas. We targeted areas lacking amphibians because existence of Bd independent of amphibians would have both ecologic and management implications. We did not detect Bd, which supports the hypothesis that it does not live independently of amphibians. However, assuming a detection sensitivity of 59.5% (based on sampling of water where amphibians tested positive for Bd), we only had 95% confidence of detecting Bd if it was in > or =16% of our sites. Further investigation into potential abiotic reservoirs is needed, but our results provide a strategic step in determining the distributional and environmental limitations of Bd in our study region.

Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics.

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Versace, Amelia; Almeida, Jorge R C; Hassel, Stefanie; Walsh, Nicholas D; Novelli, Massimiliano; Klein, Crystal R; Kupfer, David J; Phillips, Mary L

2008-09-01

Diffusion tensor imaging (DTI) studies in adults with bipolar disorder (BD) indicate altered white matter (WM) in the orbitomedial prefrontal cortex (OMPFC), potentially underlying abnormal prefrontal corticolimbic connectivity and mood dysregulation in BD. To use tract-based spatial statistics (TBSS) to examine WM skeleton (ie, the most compact whole-brain WM) in subjects with BD vs healthy control subjects. Cross-sectional, case-control, whole-brain DTI using TBSS. University research institute. Fifty-six individuals, 31 having a DSM-IV diagnosis of BD type I (mean age, 35.9 years [age range, 24-52 years]) and 25 controls (mean age, 29.5 years [age range, 19-52 years]). Fractional anisotropy (FA) longitudinal and radial diffusivities in subjects with BD vs controls (covarying for age) and their relationships with clinical and demographic variables. Subjects with BD vs controls had significantly greater FA (t > 3.0, P left uncinate fasciculus (reduced radial diffusivity distally and increased longitudinal diffusivity centrally), left optic radiation (increased longitudinal diffusivity), and right anterothalamic radiation (no significant diffusivity change). Subjects with BD vs controls had significantly reduced FA (t > 3.0, P right uncinate fasciculus (greater radial diffusivity). Among subjects with BD, significant negative correlations (P right anterothalamic radiation, as well as between medication load and FA in the left optic radiation. Decreased FA (P left optic radiation and in the right anterothalamic radiation among subjects with BD taking vs those not taking mood stabilizers, as well as in the left optic radiation among depressed vs remitted subjects with BD. Subjects having BD with vs without lifetime alcohol or other drug abuse had significantly decreased FA in the left uncinate fasciculus. To our knowledge, this is the first study to use TBSS to examine WM in subjects with BD. Subjects with BD vs controls showed greater WM FA in the left OMPFC that

Fracking in the conflict area between energy and environmental policy. The discussion in Germany and the Netherlands by comparison; Fracking im Spannungsfeld zwischen Energie- und Umweltpolitik. Die Diskussion in Deutschland und den Niederlanden im Vergleich

Energy Technology Data Exchange (ETDEWEB)

Kontny, Kerstin

2016-11-01

The shale gas production using the so-called fracking method represents for opponents the use of a high-risk technology. Proponents see it, however a technological advance, and the answer to current energy issues. For the citizens of a country, the debate involves mainly uncertainties, the technology is still associated with risks that are not only difficult to assess for the layman. Due to these uncertainties, there is a danger that scientific evidence for political purposes are exploited. Particularly exciting is therefore the question of how the subject is discussed in different countries. In Fracking in the conflict area between energy and environmental policies are the debates in natural gas country Netherlands and the country of energy transition, Germany are compared. Kerstin Kontry's research put emphasis on the parties to the debate actors, the course of the debate and the issues are discussed. The main question is to what extent the discussions are shaped by national factors. [German] Die Schiefergasfoerderung mit Hilfe der sogenannten Fracking-Methode stellt fuer Gegner die Anwendung einer Hochrisikotechnologie dar, Befuerworter sehen darin hingegen einen technologischen Fortschritt und die Antwort auf derzeitige Energiefragen. Fuer die Buerger eines Landes birgt die Debatte vor allem Unsicherheiten, ist die Technologie doch mit Risiken verbunden, die nicht nur fuer den Laien schwer einzuschaetzen sind. Aufgrund dieser Unsicherheiten droht die Gefahr, dass wissenschaftliche Erkenntnisse fuer politische Zwecke instrumentalisiert werden. Besonders spannend ist daher die Frage, wie die Thematik in unterschiedlichen Laendern diskutiert wird. In Fracking im Spannungsfeld zwischen Energie- und Umweltpolitik werden die Debatten im Erdgasland Niederlande und dem Land der Energiewende, Deutschland, verglichen. Den Schwerpunkt legt Kerstin Kontny dabei auf die an der Debatte beteiligten Akteure, den Verlauf der Debatte sowie die behandelten Themen. Dabei

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

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Kivilcim Y

2017-03-01

Full Text Available Yigit Kivilcim,1 Merih Altintas,1 Fusun Mayda Domac,2 Erkal Erzincan,1 Huseyin Gülec1 1Department of Psychiatry, 2Department of Neurology, Erenköy Mental and Neurological Diseases Training and Research Hospital, Istanbul, Turkey Purpose: The aim of this study was to evaluate the prevalence of comorbid bipolar disorder (BD among migraineurs and the impact of migraine–BD comorbidity on disease characteristics. Patients and methods: A total of 120 adult patients diagnosed with migraine at a single tertiary care center were included in this cross-sectional study. Data on sociodemographic and migraine-related characteristics, family history of psychiatric diseases, comorbid psychiatric diseases, and first-episode characteristics were recorded. Mood Disorders Diagnosis and Patient Registration Form (SCIP-TURK, Mood Disorder Questionnaire (MDQ, and Hypomania Checklist-32-Revised (HCL-32-R were applied to all patients by experienced clinicians, and clinical diagnoses were confirmed using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I. Migraine Disability Assessment Scale (MIDAS was used to evaluate the headache-related disability. Study parameters were compared between migraineurs with and without comorbid BD. Results: The diagnosis of comorbid BD was confirmed in 19.2% of migraineurs. A significantly higher percentage of patients with comorbid BD than those without comorbid BD had family history of BD (39.1% vs 6.2%, P<0.001, suicide attempt (30.4% vs 5.2%, P<0.001, and physical abuse (52.2% vs 26.8%, P=0.019. MIDAS scores were significantly higher (50.6 [43.2] vs 33.8 [42.7], P=0.0422 in migraineurs with comorbid BD than in those without comorbid BD. Multivariate logistic regression model revealed that a positive family history of type I BD (odds ratio [OR], 14.42; 95% confidence interval [CI], 2.94–70.73; P=0.001 and MIDAS scores >30 (OR, 3.69; 95% CI, 1.12–12.19; P=0.032 were associated with 14.42 times and 3.69 times

Chytrid fungus acts as a generalist pathogen infecting species-rich amphibian families in Brazilian rainforests.

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Valencia-Aguilar, Anyelet; Ruano-Fajardo, Gustavo; Lambertini, Carolina; da Silva Leite, Domingos; Toledo, Luís Felipe; Mott, Tamí

2015-05-11

The fungus Batrachochytrium dendrobatidis (Bd) is among the main causes of declines in amphibian populations. This fungus is considered a generalist pathogen because it infects several species and spreads rapidly in the wild. To date, Bd has been detected in more than 100 anuran species in Brazil, mostly in the southern portion of the Atlantic forest. Here, we report survey data from some poorly explored regions; these data considerably extend current information on the distribution of Bd in the northern Atlantic forest region. In addition, we tested the hypothesis that Bd is a generalist pathogen in this biome. We also report the first positive record for Bd in an anuran caught in the wild in Amazonia. In total, we screened 90 individuals (from 27 species), of which 39 individuals (from 22 species) were Bd-positive. All samples collected in Bahia (2 individuals), Pernambuco (3 individuals), Pará (1 individual), and Minas Gerais (1 individual) showed positive results for Bd. We found a positive correlation between anuran richness per family and the number of infected species in the Atlantic forest, supporting previous observations that Bd lacks strong host specificity; of 38% of the anuran species in the Atlantic forest that were tested for Bd infection, 25% showed positive results. The results of our study exemplify the pandemic and widespread nature of Bd infection in amphibians.

Interhemispheric disconnectivity in the sensorimotor network in bipolar disorder revealed by functional connectivity and diffusion tensor imaging analysis

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Takuya Ishida

2017-06-01

Full Text Available Background: Little is known regarding interhemispheric functional connectivity (FC abnormalities via the corpus callosum in subjects with bipolar disorder (BD, which might be a key pathophysiological basis of emotional processing alterations in BD. Methods: We performed tract-based spatial statistics (TBSS using diffusion tensor imaging (DTI in 24 healthy control (HC and 22 BD subjects. Next, we analyzed the neural networks with independent component analysis (ICA in 32HC and 25 BD subjects using resting-state functional magnetic resonance imaging. Results: In TBSS analysis, we found reduced fractional anisotropy (FA in the corpus callosum of BD subjects. In ICA, functional within-connectivity was reduced in two clusters in the sensorimotor network (SMN (right and left primary somatosensory areas of BD subjects compared with HCs. FC between the two clusters and FA values in the corpus callosum of BD subjects was significantly correlated. Further, the functional within-connectivity was related to Young Mania Rating Scale (YMRS total scores in the right premotor area in the SMN of BD subjects. Limitations: Almost all of our BD subjects were taking several medications which could be a confounding factor. Conclusions: Our findings suggest that interhemispheric FC dysfunction in the SMN is associated with the impaired nerve fibers in the corpus callosum, which could be one of pathophysiological bases of emotion processing dysregulation in BD patients. Keywords: Neuroscience, Medical imaging, Psychiatry

Executive functioning and alcohol binge drinking in university students.

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Parada, María; Corral, Montserrat; Mota, Nayara; Crego, Alberto; Rodríguez Holguín, Socorro; Cadaveira, Fernando

2012-02-01

Binge drinking (BD) is prevalent among college students. Studies on alcoholism have shown that the prefrontal cortex is vulnerable to the neurotoxic effects of alcohol. The prefrontal cortex undergoes both structural and functional changes during adolescence and young adulthood. Sex differences have been observed in brain maturation and in alcohol-induced damage. The objective of the present study was to analyze the relationship between BD and cognitive functions subserved by the prefrontal cortex in male and female university students. The sample comprised 122 undergraduates (aged 18 to 20 years): 62 BD (30 females) and 60 non-BD (29 females). Executive functions were assessed by WMS-III (Backward Digit Span and Backward Spatial Span), SOPT (abstract designs), Letter Fluency (PMR), BADS (Zoo Map and Key Search) and WCST-3. BD students scored lower in the Backward Digit Span Subtest and generated more perseverative responses in the SOPT In relation to interaction BD by sex, BD males scored lower in the Backward Digit Span test than BD females and non-BD males. BD is associated with poorer performance of executive functions subserved by the dorsolateral prefrontal cortex. The results do not support enhanced vulnerability of women to alcohol neurotoxic effects. These difficulties may reflect developmental delay or frontal lobe dysfunction. Copyright © 2011 Elsevier Ltd. All rights reserved.

The association between school exam grades and subsequent development of bipolar disorder

DEFF Research Database (Denmark)

Pedersen, Steffie Damgaard; Østergaard, Søren Dinesen; Petersen, Liselotte

2018-01-01

and bipolar I disorder (BD-I) has not been studied. Therefore, we aimed to study the association between school exam grades and subsequent development of BD and BD-I while adjusting for parental history of mental disorder. METHODS: We conducted a register-based nationwide cohort study following 505 688......OBJECTIVE: Prior studies have indicated that both high and low school grades are associated with development of bipolar disorder (BD), but these studies have not adjusted for parental history of mental disorder, which is a likely confounder. Furthermore, the association between school grades...... individuals born in Denmark between 1987 and 1995. We investigated the association between school exam grades and development of BD or BD-I with a Cox model adjusting for family history of mental disorder and other potential confounders. RESULTS: During follow-up, 900 individuals were diagnosed with BD...

Cerebral vein thrombosis in a four year old with Behçet's disease.

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Hacihamdioglu, Duygu Ovunc; Demiriz, Murat; Sobaci, Gungor; Kocaoglu, Murat; Demirkaya, Erkan; Gok, Faysal

2014-01-01

Behçet's disease (BD) is a multisystem disorder. The main pathology in BD is vasculitis that involves arteries and veins of all calibers. Central nervous system involvement occurs in 5-10% of patients. Increased morbidity and mortality is rarely observed in children. The mean age at onset in pediatric BD is approximately 7 years. Neurologic involvement in BD is usually observed after 3-6 years. We report the case of a four-year-old Turkish boy with BD with sagittal sinus thrombosis treated with infliximab. The patient presented papilledema without neurologic signs. Although long-term efficacy evaluations are needed in this case, infliximab therapy may be a good option in childhood BD with refractory sinus thrombosis. This is the youngest case of BD with sagittal sinus thrombosis reported so far. Copyright © 2012 Elsevier España, S.L. All rights reserved.

The investigation of antimicrobial peptides expression and its related interaction with methotrexate treatment in patients with psoriasis vulgaris.

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Ozlu, Emin; Karadag, Ayse Serap; Ozkanli, Seyma; Oguztuzun, Serpil; Akbulak, Ozge; Uzuncakmak, Tugba Kevser; Demirkan, Serkan; Akdeniz, Necmettin

2017-12-01

Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls. Immunohistochemical expressions of hBD-1 and hBD-2 were assessed in 16 patients with psoriasis vulgaris and 20 normal skin biopsies from healthy controls. The patients were administered a 12 week of MTX and skin biopsy samples were obtained from the lesional skin of the patients pre-/posttreatment and normal body of the healthy controls. The median (range) Psoriasis Area and Severity Index (PASI) value was 21.6 (8.2-27.7) before the treatment whereas; 3.05 (1-23.4) after the treatment. hBD-1 expression in psoriasis patients was significantly higher as compared to the healthy controls before treatment (p psoriasis patients and healthy controls in terms of hBD-2 expression before treatment (p > 0.05). No significant difference was observed between before-after MTX treatment in terms of hBD-1 and hBD-2 expression levels in psoriasis patients (p > 0.05). These findings suggest a role for hBD-1 in psoriasis pathogenesis. But MTX treatment does not affect on hBD-1 and hBD-2 expressions. Further studies are needed to assess the roles of these AMPs in psoriasis etiopathogenesis.

Differences in clinical presentation between bipolar I and II disorders in the early stages of bipolar disorder: A naturalistic study.

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Vinberg, Maj; Mikkelsen, Rie Lambaek; Kirkegaard, Thomas; Christensen, Ellen Margrethe; Kessing, Lars Vedel

2017-01-15

In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional level, the presence of comorbid personality disorders and coping strategies. Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders. Clinical symptoms were rated with the Young Mania Rating Scale and the Hamilton Depression Rating Scale, and functional status using the Functional Assessment Short Test. Cognitive complaints were assessed using the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire, the presence of comorbid personality disorders using the Standardized Assessment of Personality - Abbreviated Scale and coping style using the Coping Inventory for Stressful Situations. In total, 344 patients were included (BD I (n=163) and BD II (n=181). Patients with BD II presented with significantly more depressive symptoms, more cognitive complaints, lower overall functioning, and a higher prevalence of comorbid personality disorders. Finally, they exhibited a trend towards using less adaptive coping styles. It cannot be omitted that some patients may have progressed from BD II to BD I. Most measures were based on patient self report. Overall, BD II was associated with a higher disease burden. Clinically, it is important to differentiate BD II from BD I and research wise, there is a need for tailoring and testing specific interventions towards BD II. Copyright © 2016 Elsevier B.V. All rights reserved.

Abnormal sleep duration associated with hastened depressive recurrence in bipolar disorder.

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Gershon, Anda; Do, Dennis; Satyanarayana, Satyanand; Shah, Saloni; Yuen, Laura D; Hooshmand, Farnaz; Miller, Shefali; Wang, Po W; Ketter, Terence A

2017-08-15

Abnormal sleep duration (ASD, disorder (BD), and often persists beyond acute mood episodes. Few longitudinal studies have examined the ASD's impact upon BD illness course. The current study examined the longitudinal impact of ASD upon bipolar depressive recurrence/recovery. Outpatients referred to the Stanford BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation at baseline, and with the Clinical Monitoring Form at monthly follow-ups for up to two years of naturalistic treatment. Prevalence and clinical correlates of ASD in 93 recovered (euthymic ≥8 weeks) and 153 depressed BD patients were assessed. Kaplan-Meier analyses (Log-Rank tests) assessed relationships between baseline ASD and longitudinal depressive severity, with Cox Proportional Hazard analyses assessing potential mediators. ASD was only half as common among recovered versus depressed BD outpatients, but was significantly associated with hastened depressive recurrence (Log-Rank p=0.007), mediated by lifetime anxiety disorder and attenuated by lifetime history of psychosis, and had only a non-significant tendency towards association with delayed depressive recovery (Log-Rank p=0.07). In both recovered and depressed BD outpatients, baseline ASD did not have significant association with any baseline BD illness characteristic. Self-reported sleep duration. Limited generalizability beyond our predominately white, female, educated, insured American BD specialty clinic sample. Baseline ASD among recovered BD patients may be a risk marker for hastened depressive recurrence, suggesting it could be an important therapeutic target between mood episodes. Copyright © 2017 Elsevier B.V. All rights reserved.

Face validity of a pre-clinical model of operant binge drinking: just a question of speed.

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Jeanblanc, Jérôme; Sauton, Pierre; Jeanblanc, Virginie; Legastelois, Rémi; Echeverry-Alzate, Victor; Lebourgeois, Sophie; Gonzalez-Marin, Maria Del Carmen; Naassila, Mickaël

2018-06-04

Binge drinking (BD) is often defined as a large amount of alcohol consumed in a 'short' period of time or 'per occasion'. In clinical research, few researchers have included the notion of 'speed of drinking' in the definition of BD. Here, we aimed to describe a novel pre-clinical model based on voluntary operant BD, which included both the quantity of alcohol and the rapidity of consumption. In adult Long-Evans male rats, we induced BD by regularly decreasing the duration of ethanol self-administration from 1-hour to 15-minute sessions. We compared the behavioral consequences of BD with the behaviors of rats subjected to moderate drinking or heavy drinking (HD). We found that, despite high ethanol consumption levels (1.2 g/kg/15 minutes), the total amounts consumed were insufficient to differentiate HD from BD. However, consumption speed could distinguish between these groups. The motivation to consume was higher in BD than in HD rats. After BD, we observed alterations in locomotor coordination in rats that consumed greater than 0.8 g/kg, which was rarely observed in HD rats. Finally, chronic BD led to worse performance in a decision-making task, and as expected, we observed a lower stimulated dopaminergic release within nucleus accumbens slices in poor decision makers. Our BD model exhibited good face validity and can now provide animals voluntarily consuming very rapidly enough alcohol to achieve intoxication levels and thus allowing the study of the complex interaction between individual and environmental factors underlying BD behavior. © 2018 Society for the Study of Addiction.

Lifetime eating disorder comorbidity associated with delayed depressive recovery in bipolar disorder.

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Balzafiore, Danielle R; Rasgon, Natalie L; Yuen, Laura D; Shah, Saloni; Kim, Hyun; Goffin, Kathryn C; Miller, Shefali; Wang, Po W; Ketter, Terence A

2017-12-01

Although eating disorders (EDs) are common in bipolar disorder (BD), little is known regarding their longitudinal consequences. We assessed prevalence, clinical correlates, and longitudinal depressive severity in BD patients with vs. without EDs. Outpatients referred to Stanford University BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) affective disorders evaluation, and while receiving naturalistic treatment for up to 2 years, were monitored with the STEP-BD clinical monitoring form. Patients with vs. without lifetime EDs were compared with respect to prevalence, demographic and unfavorable illness characteristics/current mood symptoms and psychotropic use, and longitudinal depressive severity. Among 503 BD outpatients, 76 (15.1%) had lifetime EDs, which were associated with female gender, and higher rates of lifetime comorbid anxiety, alcohol/substance use, and personality disorders, childhood BD onset, episode accumulation (≥10 prior mood episodes), prior suicide attempt, current syndromal/subsyndromal depression, sadness, anxiety, and antidepressant use, and earlier BD onset age, and greater current overall BD severity. Among currently depressed patients, 29 with compared to 124 without lifetime EDs had significantly delayed depressive recovery. In contrast, among currently recovered (euthymic ≥8 weeks) patients, 10 with compared to 95 without lifetime EDs had only non-significantly hastened depressive recurrence. Primarily Caucasian, insured, suburban, American specialty clinic-referred sample limits generalizability. Small number of recovered patients with EDs limited statistical power to detect relationships between EDs and depressive recurrence. Further studies are warranted to explore the degree to which EDs impact longitudinal depressive illness burden in BD.

Top 10 research questions to promote physical activity in bipolar disorders: A consensus statement from the International Organization of Physical Therapists in Mental Health.

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Vancampfort, Davy; Rosenbaum, Simon; Probst, Michel; Connaughton, Joanne; du Plessis, Christy; Yamamoto, Taisei; Stubbs, Brendon

2016-05-01

Research has only recently started to consider the importance and applicability of physical activity (PA) for people with bipolar disorder (BD). The aim of the current study is to highlight 10 pertinent PA research questions in people with BD. The International Organization of Physical Therapy in Mental Health executed a consultation with all National organizations (n=13) to identify the most salient questions to guide future research on PA in BD. We identified the following 10 questions: (1) What are the benefits of PA for people with BD? (2) What are the most prominent safety issues for PA prescription in BD? (3) What is the optimal PA prescription for people with BD? (4) What are the key barriers to PA among people with BD? (5) What are the most effective motivational strategies for ensuring PA adoption and maintenance in BD? (6) How do we translate PA research into community practice? (7) If one treatment goal is increased physical activity, what type of professionals are needed as part of a multidisciplinary team? (8) How do we incorporate PA as a vital sign in clinical practice? (9) How can we prevent sedentary behavior in BD? (10) What is the most appropriate PA assessment method? We did not consult people with BD. Addressing these questions is critical for developing evidence-based approaches for promoting and sustaining an active lifestyle in BD. Ultimately, achieving this will reduce the burden of cardiovascular disease and improve the quality of life of this population. Copyright © 2016 Elsevier B.V. All rights reserved.

Predictors of suicide ideation among older adults with bipolar disorder.

Science.gov (United States)

O'Rourke, Norm; Heisel, Marnin J; Canham, Sarah L; Sixsmith, Andrew

2017-01-01

Bipolar disorder (BD) carries the greatest risk of death by suicide of all psychiatric conditions as 25%-50% of those with BD will make one or more suicide attempt, and about 15% will intentionally end their lives. Among young adults with BD, substance misuse, medication non-adherence, age at onset, and comorbid psychiatric conditions each predict self-harm. It is currently unclear if these same factors or others predict suicide ideation among older adults with BD. We recruited a global sample of 220 older adults with BD over 19 days using socio-demographically targeted, social media advertising and online data collection (Mean = 58.50, SD = 5.42; range 50 to 81 years). Path analyses allowed us to identify direct and indirect predictors of suicide ideation among older adults with BD. Cognitive failures (perception, memory, and motor function), depressive symptoms, alcohol misuse, and dissatisfaction with life as direct predictors of suicide ideation; duration of BD symptoms and medication non-adherence emerged as indirect predictors. Of note, the significant impact of sleep on suicide ideation is indirect via depressive symptoms, cognitive failures, medication non-adherence and life dissatisfaction. As with young adults with BD, alcohol misuse and medication non-adherence emerged as significant predictors of suicide ideation. In addition, cognitive failures directly and indirectly predict suicide ideation in this sample of older adults with BD. Population aging and treatment efficacy are leading to ever growing numbers of older adults with BD. Both direct and indirect predictors of suicide ideation need to be considered in future BD research and treatment planning.

The relative influence of individual risk factors for attempted suicide in patients with bipolar I versus bipolar II disorder.

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Bobo, William V; Na, Peter J; Geske, Jennifer R; McElroy, Susan L; Frye, Mark A; Biernacka, Joanna M

2018-01-01

To compare the relative influence (RI) of individual predictors for lifetime attempted suicide between adults with bipolar I (BDBD-I) and bipolar II disorder (BDBD-II). We conducted an analysis of data from 1465 enrollees in the Mayo Clinic Bipolar Disorder Biobank. Demographic and clinical variables and history of attempted suicide were ascertained using standardized questionnaires. Height and weight were assessed to determine body mass index (BMI); obesity was defined as BMI ≥30kg/m 2 . The frequencies of these variables were compared between persons with and without self-reported lifetime suicide attempts both overall, and within BD-I and BD-II subgroups. Gradient boosting machine (GBM) models were used to quantify the RI of study variables on the risk of lifetime attempted suicide. Nearly one-third of patients reported having a lifetime suicide attempt. Attempted suicide rates were higher in patients with BD-I than BD-II, but absolute differences were small. Lifetime attempted suicide was associated with female sex, BD-I subtype, psychiatric and substance use comorbidities, binge eating behavior, lifetime history of rapid cycling, other indicators of adverse illness course, and early age of bipolar illness onset in the entire cohort. Differences in the rank-ordering of RI for predictors of attempted suicide between BD-I and BD-II patients were modest. Rapid cycling was a strong risk factor for attempted suicide, particularly in men with BD-I. Actively psychotic or suicidal patients needing psychiatric hospitalization were initially excluded, but were approached after these acute psychiatric problems resolved. The prevalence of lifetime attempted suicide was significantly higher in BD-I than BD-II in this large, cross-sectional cohort. Predictors of attempted suicide were similar in BD-I and BD-II subgroups. Copyright © 2017. Published by Elsevier B.V.

The Effect of Human Impact on Batrachochytrium dendrobatidis prevalence in Taricha torosa

Science.gov (United States)

Deng, V.; Macario, E.; Tumey, C.

2014-12-01

Batrachochytrium dendrobatidis (Bd) is emerging as a major cause of the amphibian extinction. As amphibians serve an important role as indicator species in their ecosystem and play a vital role in the food chain, Bd will not only affect the amphibian population but also the health of the environment. Bd is an aquatic fungus that blocks the porous skin of amphibians which interrupts electrolyte, gas and water transfer. This imbalances the electrolyte system which causes cells and organs to malfunction, therefore killing the amphibian. While frogs are more common for Bd, it is not often found in newts. However, Dr. Vance Vredenburg recently found an outbreak of Bd in Taricha torosa in Marin Headlands, California. This location was used in the research as the sample site with most human impact and was expected to have the highest prevalence according to the proposed hypothesis that more human impact will correspond with a higher prevalence of Bd. Decreasing the level of human impact, Fairfield Osborn Preserve and Galbreath Preserve were picked as the other sample sites. After the samples went through qPCR, all of them came back negative for Bd. These results did not support the hypothesis, however, it contributed data to explaining the dynamics of Bd when combined with Dr. Vance Vredenburg's data from 2 months earlier. Within the two months, there was a huge difference in the prevalence of Bd as it dropped from 88% to 0%. This shows that Taricha torosa does in fact get Bd. However, it is rarely detected because Bd is fast-acting and has high mortality rates. Therefore, it is least likely for current nonspecific surveys to swab the newts during a short but lethal Bd outbreak.

Biatriosporin D displays anti-virulence activity through decreasing the intracellular cAMP levels

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Zhang, Ming; Chang, Wenqiang; Shi, Hongzhuo; Zhou, Yanhui; Zheng, Sha; Li, Ying; Li, Lin; Lou, Hongxiang, E-mail: louhongxiang@sdu.edu.cn

2017-05-01

Candidiasis has long been a serious human health problem, and novel antifungal approaches are greatly needed. During both superficial and systemic infection, C. albicans relies on a battery of virulence factors, such as adherence, filamentation, and biofilm formation. In this study, we found that a small phenolic compound, Biatriosporin D (BD), isolated from an endolichenic fungus, Biatriospora sp., displayed anti-virulence activity by inhibiting adhesion, hyphal morphogenesis and biofilm formation of C. albicans. Of note is the high efficacy of BD in preventing filamentation with a much lower dose than its MIC value. Furthermore, BD prolonged the survival of worms infected by C. albicans in vivo. Quantitative real-time PCR analysis, exogenous cAMP rescue experiments and intracellular cAMP measurements revealed that BD regulates the Ras1-cAMP-Efg1 pathway by reducing cAMP levels to inhibit the hyphal formation. Further investigation showed that BD could upregulate Dpp3 to synthesize much more farnesol, which could inhibit the activity of Cdc35 and reduce the generation of cAMP. Taken together, these findings indicate that BD stimulates the expression of Dpp3 to synthesize more farnesol that directly inhibits the Cdc35 activity, reducing intracellular cAMP and thereby disrupting the morphologic transition and attenuating the virulence of C. albicans. Our study uncovers the underlying mechanism of BD as a prodrug in fighting against pathogenic C. albicans and provides a potential application of BD in fighting clinically relevant fungal infections by targeting fungal virulence. - Highlights: • BD inhibits the filamentation of C. albicans in multiple hypha-inducing conditions. • BD can prolong the survival of nematodes infected by C. albicans. • BD stimulates the expression of Dpp3 to synthesize more farnesol. • BD reduces intracellular cAMP and regulates Ras1-cAMP-PKA pathway.

Biatriosporin D displays anti-virulence activity through decreasing the intracellular cAMP levels

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Zhang, Ming; Chang, Wenqiang; Shi, Hongzhuo; Zhou, Yanhui; Zheng, Sha; Li, Ying; Li, Lin; Lou, Hongxiang

2017-01-01

Candidiasis has long been a serious human health problem, and novel antifungal approaches are greatly needed. During both superficial and systemic infection, C. albicans relies on a battery of virulence factors, such as adherence, filamentation, and biofilm formation. In this study, we found that a small phenolic compound, Biatriosporin D (BD), isolated from an endolichenic fungus, Biatriospora sp., displayed anti-virulence activity by inhibiting adhesion, hyphal morphogenesis and biofilm formation of C. albicans. Of note is the high efficacy of BD in preventing filamentation with a much lower dose than its MIC value. Furthermore, BD prolonged the survival of worms infected by C. albicans in vivo. Quantitative real-time PCR analysis, exogenous cAMP rescue experiments and intracellular cAMP measurements revealed that BD regulates the Ras1-cAMP-Efg1 pathway by reducing cAMP levels to inhibit the hyphal formation. Further investigation showed that BD could upregulate Dpp3 to synthesize much more farnesol, which could inhibit the activity of Cdc35 and reduce the generation of cAMP. Taken together, these findings indicate that BD stimulates the expression of Dpp3 to synthesize more farnesol that directly inhibits the Cdc35 activity, reducing intracellular cAMP and thereby disrupting the morphologic transition and attenuating the virulence of C. albicans. Our study uncovers the underlying mechanism of BD as a prodrug in fighting against pathogenic C. albicans and provides a potential application of BD in fighting clinically relevant fungal infections by targeting fungal virulence. - Highlights: • BD inhibits the filamentation of C. albicans in multiple hypha-inducing conditions. • BD can prolong the survival of nematodes infected by C. albicans. • BD stimulates the expression of Dpp3 to synthesize more farnesol. • BD reduces intracellular cAMP and regulates Ras1-cAMP-PKA pathway.

Beta-defensins-2 expressions in gingival epithelium cells after probiotic Lactobacillus reuteri induction

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Tuti Kusumaningsih

2016-12-01

Full Text Available Background: Beta-defensins (BD are antimicrobial peptides that play a role in defense against pathogens. Beta-defensins (BD are expressed by a variety of epithelial cells, including gingival epithelium, salivary glands, saliva and salivary duct. BD-1 is expressed constitutively, while BD-2 and BD-3 expressions can be induced by commensal bacteria. Probiotics are commensal bacteria, thus L. reuteri as probiotic bacteria may act as “inducer” for BD-2 in epithelial gingiva. S. mutans is the main bacteria causing dental caries and sensitive to BD-2. Purpose: This study was aimed to prove that the administration of probiotic L. reuteri may improve BD-2 expressions in the gingiva epithelium. Method: This study was conducted in vivo using twenty-four male Rattus norvegicus Wistar strains aged 10-12 weeks and weighed 120-150 g. Those rats were randomly divided into four groups, namely negative control group (not induced with L. reuteri or S. mutans, positive control group (induced with S. mutans for 14 days, treatment group 1 (induced with L. reuteri for 14 days and S. mutans for 7 days, and treatment group 2 (induced with L. reuteri and S. mutans for 14 days concurrently. The concentration of L. reuteri used was 4x108cfu/ml, while the concentration of S. mutans was 1x 1010cfu/ml. 0.1 ml of each was dropped in the region of the mandibular incisors. BD-2 expression was calculated using immunohistochemical method. The difference of BD-2 expressions in gingival epithelial cells in the respective groups was analyzed by Anova/SPSS. Results: There were significant differences in BD-2 expressions in gingival epithelial cells in each group based on the results of Anova test (p=0.001. Conclusion: The administration of probiotic L. reuteri is able to increase BD-2 expressions in gingival epithelial cells.

Brain Structure and Function in Women with Comorbid Bipolar and Premenstrual Dysphoric Disorder

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Sabrina K. Syan

2018-01-01

Full Text Available IntroductionHormonal fluctuations associated with female reproductive life events may precipitate or worsen affective episodes in women with bipolar disorder (BD. Previous studies have shown that women with BD report higher rates of premenstrual dysphoric disorder (PMDD than controls. Further, bipolar women who report premenstrual worsening of mood display a worse course of their bipolar illness. Despite this, the neural correlates of comorbid BD and PMDD have not been investigated.MethodologyEighty-five [CTRL, n = 25; PMDD, n = 20; BD, n = 21; BD with comorbid PMDD (BDPMDD, n = 19], regularly cycling women, not on hormonal contraception, underwent two MRI scans: during their mid-follicular and late luteal menstrual phases. We investigated resting-state functional connectivity (Rs-FC, cortical thickness, and subcortical volumes of brain regions associated with the pathophysiology of BD and PMDD between groups, in the mid-follicular and late luteal phases of the menstrual cycle. All BD subjects were euthymic for at least 2 months prior to study entry.ResultsWomen in the BDPMDD group displayed greater disruption in biological rhythms and more subthreshold depressive and anxious symptoms through the menstrual cycle compared to other groups. Rs-FC was increased between the L-hippocampus and R-frontal cortex and decreased between the R-hippocampus and R-premotor cortex in BDPMDD vs. BD (FDR-corrected, p < 0.05. Cortical thickness analysis revealed decreased cortical thickness of the L-pericalcarine, L-superior parietal, R-middle temporal, R-rostral middle frontal, and L-superior frontal, as well as increased cortical thickness of the L-superior temporal gyri in BDPMDD compared to BD. We also found increased left-caudate volume in BDPMDD vs. BD (pCORR < 0.05.ConclusionWomen with BD and comorbid PMDD display a distinct clinical and neurobiological phenotype of BD, which suggests differential sensitivity to endogenous hormones.

Circadian Phase Preference in Pediatric Bipolar Disorder

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Kerri L. Kim

2014-03-01

Full Text Available Pediatric bipolar disorder (BD rates have notably increased over the past three decades. Given the significant morbidity and mortality associated with BD, efforts are needed to identify factors useful in earlier detection to help address this serious public health concern. Sleep is particularly important to consider given the sequelae of disrupted sleep on normative functioning and that sleep is included in diagnostic criteria for both Major Depressive and Manic Episodes. Here, we examine one component of sleep—i.e., circadian phase preference with the behavioral construct of morningness/eveningness (M/E. In comparing 30 BD and 45 typically developing control (TDC participants, ages 7–17 years, on the Morningness-Eveningness Scale for Children (MESC, no between-group differences emerged. Similar results were found when comparing three groups (BD−ADHD; BD+ADHD; TDC. Consistent with data available on circadian phase preference in adults with BD, however, we found that BD adolescents, ages 13 years and older, endorsed significantly greater eveningness compared to their TDC peers. While the current findings are limited by reliance on subjective report and the high-rate of comorbid ADHD among the BD group, this finding that BD teens demonstrate an exaggerated shift towards eveningness than would be developmentally expected is important. Future studies should compare the circadian rhythms across the lifespan for individuals diagnosed with BD, as well as identify the point at which BD youth part ways with their healthy peers in terms of phase preference. In addition, given our BD sample was overall euthymic, it may be that M/E is more state vs. trait specific in latency age youth. Further work would benefit from assessing circadian functioning using a combination of rating forms and laboratory-based measures. Improved understanding of sleep in BD may identify behavioral targets for inclusion in prevention and intervention protocols.

Sexual behavior in women with bipolar disorder.

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Mazza, Marianna; Harnic, Desiree; Catalano, Valeria; Di Nicola, Marco; Bruschi, Angelo; Bria, Pietro; Daniele, Antonio; Mazza, Salvatore

2011-06-01

There is a lack of studies regarding sexuality and sexual behavior in women with bipolar disorder. The aim of this study is to investigate sexual behavior in women affected by bipolar disorder in order to stimulate interest and debate in this area of care. Sixty women (30 BD I and 30 BD II) consent to participate in the study and were included in the sample. Moreover, sixty female healthy subjects without histories of psychiatric disorders were recruited as normal controls. Patients and healthy subjects were given the Sexual Interest and Sexual Performance Questionnaire, a questionnaire devised to explore various aspects of sexual behavior. The results of the present study suggest an increase of sexual interest in patients with BD I as compared both with BD II patients and healthy controls. In women with BD I such increase of interest was detected on some items of section I of the Sexual Interest and Sexual Performance Questionnaire, in particular "Actual Value of Sexuality" and "Implicit Sexual Interest", which implicitly explore sexual interest without overtly focusing upon sexual problems. Moreover, we observed a higher desired frequency of intercourse in women with BD I than BD II and a higher occurrence of repeated sexual intercourse in women with BD I than BD II. The main finding of the present study was an increase of sexual interest in BD I as compared with BD II female patients and normal controls. This result was detected when sexual interest was explored implicitly. Our study is limited by the small size of our subject groups. Further investigations on larger subject samples are needed to better clarify particular aspects of sexual behavior of BD patients. Copyright © 2010 Elsevier B.V. All rights reserved.

Potential brain death organ donors - challenges and prospects: A single center retrospective review

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Yousef Al-Maslamani

2014-01-01

Full Text Available Organ donation after brain death (BD is a major source for obtaining transplantable organs for patients with end-stage organ disease (ESOD. This retrospective, descriptive study was carried out on all potential BD patients admitted in different intensive care units (ICUs of the Hamad medical Corporation (HMC, Doha, Qatar during a period from January 2011 to April 2012. Our aim was to evaluate various demographic criteria and challenges of organ donation among potential BD organ donors and plan a strategy to improve the rate of organ donation in Qatar. Various aspects of BD patients in the ICUs and their possible effects on organ donation were studied. The time intervals analyzed to determine the possible causes of delay of organ retrieval were: time of diagnosing fixed dilated pupils in the ICU, to performing the first BD test, then to the second BD test, to family approach, to organ retrieval and/or circulatory death (CD without organ retrieval. There were a total of 116 potential BD organ donors of whom 96 (82.75% were males and 20 (17.25% were females. Brain hemorrhage and head injury contributed to 37 (31.9% and 32 (27.6% BD cases, respectively. Time interval between diagnosing fixed dilated pupil and performing the first test of BD was delayed >24 h in 79% of the cases and between the first and second BD tests was >6 h in 70.8% of the cases. This delay is not compatible with the Hamad Medical Corporation (HMC policy for BD diagnosis and resulted in a low number of organs retrieved. BD organ donation, a potential source for organs to save patients with ESOD has several pitfalls and every effort should be made to increase the awareness of the public as well as medical personnel to optimize donation efficacy.

Münchenis valmib moodne jalgpallistaadion

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2004-01-01

2003. a. veebruaris valiti välja šveitsi arhitektide Jacques Herzogi ja Pierre de Meuroni ovaalse kujuga "autorehvi" projekt. Peatöövõtja: Alpine Bau Deutschland GmbH. 2006. a. toimub staadionil jalgpalli maailmameistrivõistluste avamäng. 1 ill