WorldWideScience

Sample records for bundesrepublik deutschland bd

  1. Umweltberichterstattung in der Bundesrepublik Deutschland : Institutionen, Datenquellen, Literatur

    OpenAIRE

    Meyer, Wolfgang

    1989-01-01

    Der Autor vermittelt einen Überblick über den Stand der Umweltberichterstattung in der Bundesrepublik Deutschland. Um Defizite in der Vereinheitlichung aufzuarbeiten, faßt Meyer das Informationsmaterial unter dem Blickwinkel sozialer Indikatoren zusammen. Im ersten Teil listet der Verfasser innerhalb der Umweltberichterstattung Publikationen vom Statistischen Bundesamt, Umweltbundesamt, Rat der Sachverständigen für Umweltfragen, von Bundesministerien und Bundesämtern, Landesministerien und La...

  2. Private Kunst- und Kulturförderung in der Bundesrepublik Deutschland

    OpenAIRE

    Weiland, Anna

    2017-01-01

    Die Dissertation „Private Kunst- und Kulturförderung in der Bundesrepublik Deutschland“ zeichnet die historische Entwicklung des privaten Kunst- und Kulturengagement in der Bundesrepublik Deutschland von 1945 bis in die unmittelbare Gegenwart nach. Besonderes Augenmerk liegt auf der unternehmerischen Kunstförderung, die ihren Ursprung in der mäzenatischen Kunstleidenschaft einzelner Personen bzw. Unternehmer nach dem Zweiten Weltkrieg hat. Bisherige Untersuchungen, die sich dem Thema überwieg...

  3. Emission control at stationary sources in the Federal Republic of Germany. Vol 1. Sulphur oxide and nitrogen oxide emission control; Massnahmen zur Emissionsminderung bei stationaeren Quellen in der Bundesrepublik Deutschland. Bd. 1. Minderung der SO{sub 2}- und NO{sub x}-Emissionen

    Energy Technology Data Exchange (ETDEWEB)

    Rentz, O.; Schleef, H.J.; Dorn, R.; Sasse, H.; Karl, U.

    1997-05-01

    Primaer- und Sekundaermassnahmen in den emissionsrelevanten Industriesektoren fuer SO{sub 2}- und NO{sub x} in Deutschland. Der Bericht gibt einen Ueberblick ueber die Entwicklung der SO{sub 2}- und NO{sub x}-Emissionen in ausgewaehlten europaeischen Laendern waehrend der letzten 20 Jahre und in Europa. Daran schliessen sich aktuelle nationale und europaeische Grenzwerte und Richtlinien zu der SO{sub 2}- und NO{sub x} Emissionen aus stationaeren Quellen an. Der Anwendungsstand von Massnahmen zur Minderung der SO{sub 2}- und NO{sub x}-Emissionen wird fuer jeden relevanten Industriesektor untersucht und primaere Minderungsoptionen beschrieben. Spezielle Prozesseinheiten mit direktem Kontakt von Flamme und Prozessgut werden in den einzelnen Prozessen diskutiert, waehrend externe Verbrennungsprozesse zur ausschliesslichen Bereitstellung von Prozesswaerme und elektrischer Energie sektoruebergreifend in einem separaten Kapitel behandelt werden. Der Bericht schliesst mit einem Ueberblick ueber die zur Verfuegung stehenden sekundaeren Minderungsmassnahmen. Fuer die einzelnen Sektoren werden Beispiele fuer Investitionen und Kosten fuer installierte Minderungstechnologien gegeben, die als einzelfallabhaengig anzusehen sind. Zusaetzlich stellten die Anbieter von Emissionsminderungstechnologien Verfahrensbeschreibungen ihrer Produkte einschliesslich Referenzen zur Verfuegung, die im Bericht enthalten sind. (orig.)

  4. Water emission inventory for the Federal Republic of Germany; Emissionsinventar Wasser fuer die Bundesrepublik Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, E.; Hillenbrand, T.; Marscheider-Weidemann, F.; Schempp, C. [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany); Fuchs, S.; Scherer, U. [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Siedlungswasserwirtschaft; Luettgert, M. [RISA Sicherheitsanalysen GmbH, Berlin (Germany)

    2000-11-01

    Within the frame of this project, a concept for setting up exemplary emission inventories for water was put forward. An overview is given of the international activities on emission inventories and the status of national emission inventories. Based on the data situation in Germany, it was necessary to include both plant-specific, aggregated and calculated data of the point sources in the inventories. Due to their increasing significance, diffuse material emissions into water were also taken into account. Based on the conceptual work, exemplary emission inventories were compiled for nitrogen, phosphorous and adsorbable organic combined halides (AOX) as well as the heavy metals arsenic, cadmium, chrome, copper, mercury, nickel, lead and zinc. These were evaluated according to the areas of origin (sectors) or the emission paths as well as according to the large river basins Danube, Rhine, Ems, Weser, Elbe, Oder, North Sea and Baltic Sea. In addition, lists of the ten largest industrial direct dischargers were compiled. (orig.) [German] Im Rahmen dieses Vorhabens wurde ein Konzept fuer die Erstellung von beispielhaften Emissionsinventaren fuer Gewaesser erarbeitet. Es wird ein Ueberblick ueber die internationalen Aktivitaeten zu Emissionsinventaren und den Stand beim Aufbau von nationalen Emissionsinventaren gegeben. Auf Grund der Datensituation in Deutschland war es erforderlich, dass sowohl anlagenspezifische als auch aggregierte sowie berechnete Daten der Punktquellen in die Inventare einbezogen wurden. Wegen ihrer zunehmenden Bedeutung werden die diffusen Stoffeintraege in die Gewaesser ebenfalls beruecksichtigt. Aufbauend auf den konzeptionellen Arbeiten wurden beispielhafte Emissionsinventare fuer Stickstoff, Phosphor und adsorbierbare organisch gebundene Halogene (AOX) sowie die Schwermetalle Arsen, Cadmium, Chrom, Kupfer, Quecksilber, Nickel, Blei und Zink zusammengestellt. Die Auswertung erfolgte sowohl nach den Herkunftsbereichen (Branchen) bzw. den

  5. Die Säuglingsflasche. Dinghistorische Perspektiven auf Familienbeziehungen in der Bundesrepublik Deutschland und in Schweden (1950–1980

    Directory of Open Access Journals (Sweden)

    Verena Limper

    2016-11-01

    Full Text Available Between 1950 and 1980 children were increasingly raised with bottle-feeding products in the Federal Republic of Germany. There were plenty of products on offer and the marketing strategies of the food production companies were intricate. This cannot, however, have been the sole reason for the increasing use of the baby bottle. The bottle will be analysed using a History of Things approach: how did it enter the family and how did it change the relations between mothers, fathers and infants? For mothers, the baby bottle promised greater freedom in organising their everyday lives; fathers were able to redefine their masculinity by feeding the baby themselves. In Sweden, care for infants and small children as well as the responsibilities of men in child-rearing were addressed and demanded earlier than in the Federal Republic of Germany. In both countries, it can be observed that the baby bottle – among other factors – played a key role in shaping the family during the 20th century. In both countries, this was a controversial affair. Zwischen 1950 und 1980 wurden Säuglinge in der Bundesrepublik zunehmend mit Flaschenmilch ernährt. Die Produktpalette war groß, und die Werbestrategien der Nahrungsmittelhersteller waren ausgeklügelt. Dies allein kann jedoch nicht der Grund für die steigende Nutzung der Säuglingsflasche gewesen sein. Sie wird hier mit einer explizit dinghistorischen Perspektive untersucht: Wie kam sie in die Familie, und wie veränderte sie die Beziehungen von Müttern, Vätern und Säuglingen? Müttern versprach die Säuglingsflasche mehr Freiheiten in der Gestaltung ihres Alltags; Vätern ermöglichte sie es, ihre Männlichkeit neu zu definieren, indem die Väter ihre Kinder selbst fütterten. Eher als in der Bundesrepublik wurde in Schweden die Versorgung von Kleinkindern diskutiert und eine stärkere Mitverantwortung der Männer für die Familie gefordert. Für beide Länder lässt sich beobachten, dass die S

  6. Deutschland

    Directory of Open Access Journals (Sweden)

    Katja Mruck

    2000-01-01

    Full Text Available Angesichts der (sub- disziplinären Vielgestaltigkeit qualitativer Sozialforschung in Deutschland soll der vorliegende Beitrag einen ersten und notwendig schemenhaften Überblick geben über einige paradigmatische Gemeinsamkeiten und historische Entwicklungslinien, über verwendete Erhebungs- und Auswertungsverfahren, über die Situation in Forschung und Lehre und über die Nutzung von Internet-Ressourcen. Abschließend werden einige Aspekte skizziert, die besonders diskussions- und entwicklungsbedürftig erscheinen. URN: urn:nbn:de:0114-fqs000148

  7. Mining in the Federal Republic of Germany 2012. Mining industries and statistics. 64th year 2013. Documentation; Der Bergbau in der Bundesrepublik Deutschland 2012. Bergwirtschaft und Statistik. 64. Jahrgang 2013. Dokumentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-11-15

    The annual report of the series ''The mining industry in the Federal Republic of Germany - Mountain Economics and Statistics'' is published by the Federal Ministry of Economics and Technology in cooperation with the mining authorities of the federal states. It contains comprehensive data of all production facilities of mining industry in Germany and describes the position of the German industry in the context of the overall economic development. The report shows an interest in local raw materials as well as on the international raw materials economy. Moreover, the present publication provides a detailed statistics section. [German] Der Jahresbericht in der Reihe ''Der Bergbau in der Bundesrepublik Deutschland - Bergwirtschaft und Statistik'' wird vom Bundesministerium fuer Wirtschaft und Technologie in Zusammenarbeit mit den Bergbehoerden der Bundeslaender herausgegeben. Er enthaelt umfassende Daten aller Produktionsbetriebe des Bergbaus in Deutschland und beschreibt die Lage des deutschen Bergbaus im Zusammenhang mit der gesamtwirtschaftlichen Entwicklung. Der Bericht geht sowohl auf heimische Rohstoffe als auch auf die internationale Rohstoffwirtschaft ein. Darueber hinaus liefert die vorliegende Publikation einen ausfuehrlichen Statistikteil.

  8. Spent nuclear fuel reprocessing and international law. Germany`s obligations under international law in matters of spent fuel reprocessing and the relevant contracts concluded with France and the United Kingdom; Wiederaufarbeitung und Voelkerrecht. Die voelkerrechtlichen Verpflichtungen der Bundesrepublik Deutschland gegenueber der Franzoesischen Republik und dem Vereinigten Koenigreich auf dem Gebiet der Wiederaufarbeitung

    Energy Technology Data Exchange (ETDEWEB)

    Heintschel v. Heinegg, W. [Augsburg Univ. (Germany). Juristische Fakultaet

    1999-01-01

    Auswaertigen Amt und dem britischen Botschafter in Bonn. In diesem Beitrag wird daher zunaechst der Frage nachgegangen, ob und welchen voelkerrechtlichen Bindungen die beteiligten Staaten in bezug auf die Wiederaufarbeitung unterliegen. Sodann wird untersucht, welche Ansprueche Frankreich und das Vereinigte Koenigreich gegenueber der Bundesrepublik Deutschland geltend machen koennten, wenn diese sich in Widerspruch zu ihren voelkerrechtlichen Pflichten setzte. (orig./CB)

  9. Kriegsdienstverweigerung in der Bundesrepublik Deutschland Conscientious Objection in Germany

    OpenAIRE

    Margarete Haberhauer; Helmut Maneval

    2000-01-01

    As to the right and the volume of conscientious objection Germany has an exceptional position. At first this paper deals with the legal basis of conscientious objection and presents the number of applications for recognition of conscientious objection from 1958 to 1998. Then hypotheses are formulated for the analysis of conscientious objection time series. In spite of difficulties regarding operationalisation and not completely satisfying data the empirical testing produces acceptable results.

  10. Das religiöse Leben der „Gastarbeiter“ aus Bosnien-Herzegowina in Deutschland in den 1970er und 1980er Jahren

    Directory of Open Access Journals (Sweden)

    Duranović, Amir

    2014-08-01

    Full Text Available Jugoslawische und insbesondere bosnisch-herzegowinische Arbeitsmigranten in der Bundesrepublik Deutschland waren und sind Thema verschiedener wissenschaftlicher Studien sowohl der deutschsprachigen Südosteuropaforschung als auch zunehmend der Geschichtswissenschaft im postjugoslawischen Raum. Und doch weist dieser Themenbereich diverse Forschungslücken auf. Zu den Forschungsdesideraten gehört auch die Frage nach dem religiösen Leben der „Gastarbeiter“ aus Bosnien-Herzegowina in der Bundesrepublik in den etwas mehr als zwei Jahrzehnten seit Ende der 1960er Jahre bis zum Zerfall des sozialistischen Jugoslawiens. Der vorliegende Beitrag stellt erste Ergebnisse eines umfangreicheren Forschungsprojektes dar, im Rahmen dessen die bosnisch-herzegowinische Migration in der zweiten Hälfte des 20. Jahrhunderts untersucht wird.

  11. [Deutschland, Russland und das Baltikum] / Bogus̮aw Dyba{250}

    Index Scriptorium Estoniae

    Dyba{250}, Bogus̮aw

    2006-01-01

    Rets. rmt.: Deutschland, Russland und das Baltikum. Beiträge zu einer Geschichte wechselvoller Beziehungen. Festschrift zum 85. Geburtstag von Peter Krupnikow, hrsg. v. Florian Anton und Leonid Luks (=Schriften des Zentralinstituts für Mittel- und Osteuropastudien. Bd.7), Böhlau Verlag, Köln-Weimar-Wien, 2005

  12. [Deutschland, Russland und das Baltikum] / Bogus̮aw Dyba{250}

    Index Scriptorium Estoniae

    Dyba{250}, Bogus̮aw

    2006-01-01

    Rets. rmt.: Deutschland, Russland und das Baltikum. Beiträge zu einer Geschichte wechselvoller Beziehungen. Festschrift zum 85. Geburtstag von Peter Krupnikow, hrsg. v. Florian Anton und Leonid Luks (=Schriften des Zentralinstituts für Mittel- und Osteuropastudien. Bd.7), Böhlau Verlag, Köln-Weimar-Wien, 2005

  13. Vorgehensmodelle in Deutschland

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Linssen, Oliver

    2015-01-01

    In der Praxis finden viele unterschiedliche Vorgehensmodelle Anwendung, was oft in Problemen resultiert, da sich z.B. Philosophie, Projektstruktur, Terminologie oder Rollenmodelle und Aufgabenzuordnung unterscheiden. Ziel dieses Beitrags ist es, eine Karte zu zeichnen, in welcher die in Deutschla...... die Auswahl und das Tailoring von Vorgehensmodellen in der Regel nur wenig systematisch und individuell durch Projektleiter erfolgen. Vorgehensmodelle in Deutschland: Nutzung von 2006-2013 im Überblick. Available from: https://www.researchgate.net/publication/274710189_Vorgehensmodelle...

  14. Zur Soziolinguistik in der Bundesrepublik Deutschland (Sociolinguistics in the Federal Republic of Germany)

    Science.gov (United States)

    Jachnow, Helmut

    1975-01-01

    Traces the history of sociolinguistic studies in West Germany from the early nineteenth century with Humboldt and reports on the state and purposes of sociolinguistic studies in present-day Federal Republic of Germany. Available from Liber Laeromedel, Box 1205, S-22105 Lund, Sweden (Text is in German.) (TL)

  15. Zur Soziolinguistik in der Bundesrepublik Deutschland (Sociolinguistics in the Federal Republic of Germany)

    Science.gov (United States)

    Jachnow, Helmut

    1975-01-01

    Traces the history of sociolinguistic studies in West Germany from the early nineteenth century with Humboldt and reports on the state and purposes of sociolinguistic studies in present-day Federal Republic of Germany. Available from Liber Laeromedel, Box 1205, S-22105 Lund, Sweden (Text is in German.) (TL)

  16. Demokratie und Alltag. Neuere Literatur zur Politisierung des Privaten in der Bundesrepublik Deutschland

    DEFF Research Database (Denmark)

    Siegfried, Detlef

    2006-01-01

    historie, Tyskland 1945-, demokrati, hverdag, politik og privatliv, musik, seksualitet, maoisme, offentlighed......historie, Tyskland 1945-, demokrati, hverdag, politik og privatliv, musik, seksualitet, maoisme, offentlighed...

  17. Germany and the nuclear non-proliferation; Current situation and prospects; Deutschland und die nukleare Nichtverbreitung; Zwischenbilanz und Ausblick

    Energy Technology Data Exchange (ETDEWEB)

    Preisinger, J.

    1993-07-01

    A summary is given of the consequences, both positive and negative, of international non-proliferation policy. The numerous, complex branches and connections of national measures and inter-stake agreements for the peaceful, controlled uses of nuclear technology and related military technologies are expertly described, and assessed on their effectiveness. Weak aspects of the nuclear non-proliferation regime are pointed out and past reforms are illustrated and assessed in the light of recent developments. The interests of the German Federal Republic from the centre of this analysis. The author shows that, after a certain hesitary, German diplomacy has now become active in the establishment of an international non-proliferation regime. He concludes that Germany should take a strong initiative role in maintaining a peaceful international nuclear order. (orig.) [Deutsch] Es wird ein Resuemee der bisherigen Erfolge und Misserfolge internationaler Nichtverbreitungspolitik gezogen. Die komplexen, vielfach veraestelten und verschachtelten nationalen Massnahmen und zwischenstaatlichen Vereinbarungen zur Ueberwachung und friedlichen Zweckbindung von Nukleartechnologie und militaerisch relevanten Anschlusstechnologien werden sachkundig erlaeutert und auf ihre Wirksamkeit ueberprueft. Schwachstellen des nuklearen Nichtverbreitungsregimes werden offengelegt, Reformschritte der vergangenen Jahre werden dargestellt und im Lichte der juengsten Entwicklungen bewertet. Dabei steht die Interessenlage der Bundesrepublik Deutschland im Zentrum der Analyse. Der Autor zeigt, dass die deutsche Diplomatie sich nach einer gewissen Zurueckhaltung schliesslich aktiv in die Gestaltung des internationalen Nichtverbreitungsregimes eingeschaltet hat. Er plaediert fuer eine kraftvolle Initiativrolle Deutschlands zur Erhaltung einer friedlichen internationalen Nuklearordnung. (orig.)

  18. Axel Schildt, Detlef Siegfried: Deutsche Kulturgeschichte. Die Bundesrepublik von 1945 bis zur Gegenwart. München u.a.: Carl Hanser Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Pascal Eitler

    2010-07-01

    Full Text Available Der vorliegende Band liefert einen überaus perspektivenreichen und umfassend kontextualisierten Überblick zur Kulturgeschichte der Bundesrepublik Deutschland. Sozial- und politikhistorischen Untersuchungsfeldern widmen sich die Autoren dabei ebenso eingehend wie medien- und konsum- oder körper- und geschlechtergeschichtlichen Fragestellungen. Durchgehend auf dem Stand der neueren Forschung rücken sie dabei den Zeitraum zwischen Ende der 1950er und Mitte der 1980er Jahre ins Zentrum ihres Interesses. Notgedrungene Verkürzungen können den Eindruck dieser Pionierleistung nicht trüben.The volume at hand provides an overview of the cultural history of the Federal Republic of Germany that is exceedingly rich in perspectives and extensively contextualized. The authors devote themselves to social and political fields of study equally as well as to historical questions related to media and consumerism or body and gender. They focus their interest on the time period between the end of the 1950s and the middle of the 1980s, while consistently taking the most recent research into account. That they sometimes must abbreviate their findings does not damage the positive opinion of this pioneering study.

  19. Die gesetzliche Frauenquote in Deutschland

    OpenAIRE

    Amling, Svenja

    2011-01-01

    In der vorliegenden Arbeit wird auf eine per Gesetz vorgeschriebene Frauenquote in Deutschland eingegangen. Im Fokus steht die Frage, ob Frauendiskriminierung durch eine solche Vorschrift tatsächlich bekämpft werden kann oder ob vielmehr die Männer diskriminiert würden. Zudem werden mögliche Unterschiede in den Führungsstilen zwischen Frauen und Männern untersucht sowie einige bereits vorhandene Frauenquoten in Politik und Wirtschaft vorgestellt.

  20. Gesa Anne Busche: Über-Leben nach Folter und Flucht. Resilienz kurdischer Frauen in Deutschland. Bielefeld: transcript Verlag 2013.

    Directory of Open Access Journals (Sweden)

    Heinz-Jürgen Voß

    2013-10-01

    Full Text Available Die Asylbedingungen in der Bundesrepublik Deutschland sind für Menschen, die vor Verfolgung und Folter fliehen mussten, problematisch und teilweise lebensbedrohlich. Traumatisierungen werden nicht oder unzureichend behandelt und durch die Asylbedingungen häufig noch verstärkt. Gesa Anne Busche befragte vier kurdische Frauen, die vor Verfolgung und Folter in der Türkei geflohen sind und in der Bundesrepublik Asyl suchten. Sie gewährt mit ihrem Buch einen Zugang, der jedoch fundierter und näher an der Perspektive der interviewten Frauen hätte sein müssen. Ihre eigenen Vorannahmen hätten im Forschungsprozess aktiv und unter anderem auf Grundlage von Arbeiten von Frauen of Color reflektiert werden können – dass das nicht geschehen ist, schmälert den Ertrag des Buches deutlich.The conditions for asylum in the Federal Republic of Germany are problematic and in parts even life-threatening for people, who had to flee from persecution and torture. Traumatizations are not or insufficiently treated and often even intensified through the conditions for asylum. Gesa Anne Busche interviewed four Kurdish women, who fled from persecution and torture in Turkey and sought asylum in Germany. Her book offers an approach, which should, however, have been closer to the perspective of the interviewed women. During the research process, her own presuppositions could have been reflected on, among others, based on works by Women of Color – the fact that this was not done reduces the book’s benefit considerably.

  1. Einige Gesichtspunkte der Handelsbeziehungen zwischen Sozialistischer Republik Rumänien und Bundesrepublik Deutschland (1960-1990

    Directory of Open Access Journals (Sweden)

    Lucian Fedor

    2011-07-01

    Full Text Available After the establishment of the first transactions of import and export from machines-building industry and food industry in the late 50’s, the economic and commercial relations between Socialist Romania and West Germany had a special evolution both at institutional and financial level in the 7-th and 8-th decades. The bilateral trade relations were characterized by structural asymmetry of the trade, long-term inequity interchange, Romanian exports dominated by products of light-industry and West-German exports dominated by heavy-industry products. The Federal Republic of Germany was for Romania the most important West European economic partner, with a decisive role in the industrialization and economic growth of our country in the 60’s and 70’s.

  2. WANDLUNGEN DER ERWACHSENENBILDUNG IN DER BUNDESREPUBLIK DEUTSCHLAND (CHANGES IN ADULT EDUCATION IN THE FEDERAL REPUBLIC OF GERMANY).

    Science.gov (United States)

    TIETGENS, HANS

    ALTHOUGH EUROPEAN ADULT EDUCATION GREW OUT OF THE AGE OF ENLIGHTENMENT, THE GERMAN MOVEMENT LONG TENDED TO REJECT THIS ORIGIN. EVEN AFTER 1945, ADULT EDUCATION IN GERMANY WAS JUSTIFIED BY CONSIDERATIONS OF MASS SOCIETY. SINCE THEN, HOWEVER, THE MOBILITY OF SOCIETY HAS COME TO BE CONSIDERED THE DETERMINING FACTOR. THE "VOLKSHOCHSCHULEN"…

  3. Petroleum and natural gas in the Federal Republic of Germany 2001; Erdoel und Erdgas in der Bundesrepublik Deutschland 2001

    Energy Technology Data Exchange (ETDEWEB)

    Pasternak, M.; Kosinowski, M.; Loesch, J.; Messner, J.; Sedlacek, R.

    2002-07-01

    After the last years had seen the lowest level of exploration activities, the year 2001 marked a distinct increase of exploration activities. This became quite visible in the number of completed exploration wells and in the extent of seismic surveys. Two of four new-field wildcats were completed in 2001, however without success. One of the three additional exploration wells (new-pool test and new-tectonic block) found gas. In production drilling nine of twelve wells were successful. Footage increased by near 25% compared to the preceding year and amounted to 54 030 metres. Seen in the light of history since 1945, this value marks the last but one rank compared to the last rank of the previous year. The rise of footage was achieved exclusively by exploration drilling. Footage of production drilling was slightly down. In geophysical prospecting the activities in 3D seismics reached the same level as in times of maximum seismic activities. The total area of 2400 square kilometres even exceeded the previous maximum. The main contribution was delivered by only one offshore survey in the German North Sea. 2D seismic was rather low and amounted to 450 kilometres in total. The license area for oil and gas exploration was reduced even further. As in previous years several expired licences were not extended and in some cases parts of the licence areas were relinquished. One licence around the city of Bremen was newly awarded. Two licences were awarded due to reorganisation of licence areas respectively due to adaptation to frontiers. In the state of Nordrhein-Westfalen three smaller licence areas were newly awarded aiming at producing gas from abandoned coal mines. German oil production could increase to 3.44 million metric tons due to the increase in production from the oil field Mittelplate to 1.6 million tons. In all other fields oil production decreased because of normal decline in production. Total remaining proven and probable oil reserves are reduced by 3 million tons to 46.8 million tons. Contrary to the trend of the last years the total remaining proven and probable natural gas reserves (raw gas) dropped by 34.4 billion cubic metres to 342.9 billion cubic metres due to production and the reassessment of existing fields. Reserve figures were 9% below the value of the preceding year. The gas production amounted to 21.5 billion cubic metres and equals the previous year value. The growth in underground gas storage continued. As in the preceding year 23 gas storage facilities in porous rocks and 19 gas storage facilities in salt caverns were in operation. The working gas volume increased by 0.5 billion cubic metres to 19.1 billion cubic metres. At present it is planned to raise the working gas volume by 4.4 billion cubic metres by building new storage facilities respectively by extension of existing facilities. (orig.)

  4. Crude oil and natural gas in the Federal Republic of Germany 1997; Erdoel und Erdgas in der Bundesrepublik Deutschland 1997

    Energy Technology Data Exchange (ETDEWEB)

    Pasternak, M.; Kosinowski, M.; Loesch, J.; Meyer, H.J.; Porth, H.; Sedlacek, R.

    1998-12-31

    In 1997, exploration for oil and gas in onshore Germany further slowed down compared to the previous years. Both the number of exploration wells and the geophysical activity (seismic and gravimetric field surveys) decreased. In contrast, extensive seismic measurements were conducted in the German sector of the North Sea. Oil production amounted to 2.82x10{sup 6} t which is approximately the same level as in 1996. Due to the mild winter, gas production slightly decreased to 22.5x10{sup 9} m{sup 3} (raw gas). Underground gas storage in depleted oil or gas fields, in aquifer structures and salt caverns continued to play a very important role in Germany. The total working gas capacity of the 38 existing storage plants increased by 1.3x10{sup 9} m{sup 3} to 15.4x10{sup 9} m{sup 3}. An additional capacity of 7.1x10{sup 9} m{sup 3} is under construction or in the planning stage. (orig./MSK) [Deutsch] Im Jahre 1997 ist die Aufsuchungstaetigkeit nach Erdgas und Erdoel auf dem deutschen Festland gemessen an der Anzahl der Explorationsbohrungen und dem Umfang der geophysikalischen Feldmessungen (Seismik, Gravimetrie) dem Trend des Vorjahres folgend zurueckgegangen. Demgegenueber standen umfangreiche seismische Untersuchungen in der Nordsee. Die Erdoelfoerderung hat sich mit 2,82 Mio. t ungefaehr auf dem Niveau des Vorjahres gehalten. Die Erdgasfoerderung hat gegenueber 1996 witterungsbedingt geringfuegig abgenommen und betrug 22,5 Mrd. m{sup 3}(V{sub n})/a (natuerlicher Brennwert). Auf dem Sektor der Untertage-Erdgasspeicher (ehem. Lagerstaetten, Aquifere und Salzkavernen) setzte sich auch im Jahre 1997 der Wachstumstrend fort. Gegenueber dem Vorjahr stieg das Arbeitsgasvolumen in 23 Porenspeicher- und 15 Kavernenspeicher-Betrieben um etwa 1,3 Mrd. m{sup 3}(V{sub n}) auf 15,4 Mrd. m{sup 3}(V{sub n}) an. Weitere ca. 7,1 Mrd. m{sup 3}(V{sub n}) Arbeitsgas sind in neuen Projekten oder durch Erweiterung bestehender Projekte in Planung und Bau. (orig./MSK)

  5. [Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2015-01-01

    Arvustus: Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik (Hamburger Beiträge zur Sozizl- und Zeitgeschichte, 51). Wallstein Verlag. Göttingen 2013

  6. [Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2015-01-01

    Arvustus: Prehn, Ulrich. Max Hildebert Boehm. Radikales Ordnungsdenken vom Ersten Weltkrieg bis in die Bundesrepublik (Hamburger Beiträge zur Sozizl- und Zeitgeschichte, 51). Wallstein Verlag. Göttingen 2013

  7. Primary energy consumption in Germany 2001; Primaerenergieverbrauch in Deutschland 2001

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2002-03-01

    Vorjahr 2000 kraeftig gestiegen, und zwar um 1,6% von ca. 487,2 Mio. SKE auf ca. 494,8 Mio. t SKE. Der Mehrverbrauch entspricht 7,6 Mio. t SKE. Diese Aufwaertsentwicklung ist in erster Linie auf die im Vergleich zum Jahr 2000 erheblich kuehlere Witterung zurueckzufuehren, da von der schwachen Konjunktur verbrauchssteigernde Impulse weitgehend ausblieben. Nach wie vor ist die Bundesrepublik Deutschland ein ausgesprochenes Energieimportland. Die inlaendische Energiegewinnung betrug im Jahr 2001 ca. 122,6 Mio. t SKE, entsprechend einem Anteil am Gesamtverbrauch von ca. 25%. Die Importabhaengigkeit lag mit rd. 372,2 Mio. t SKE bei rd. 75%. Minerloel ist weiterhin mit einem Anteil von 38,4% wichtigster Primaerenergietraeger, gefolgt von Erdgas mit 21,5%, Steinkohle mit 13,1%, Kernenergie mit 12,9%, Braunkohle mit 11,2% und den sonstigen Energietraegern (Wasser-/Windkraft, Muell) mit ca. 2,8%. Die Energiepreise, die im ersten Halbjahr 2001 noch auf einem hohen Niveau verharrt hatten, sanken in der zweiten Jahreshaelfte unter den Vorjahresstand. Stromerzeugung und -verbrauch sind im Jahre 2001 um 0,5% gestiegen. Die Bruttostromerzeugung erreichte mit ca. 570,0 Mrd. kWh ein um rd. 7 Mrd. kWh hoeheres Ergebnis als im Vorjahr 2000 mit ca. 563,0 Mrd. kWh. Nach wie vor rangiert die Kernenergie bei der Stromerzeugung an erster Stelle und verzeichnet mit 171,3 Mrd. kWh fuer das Jahr 2001 das bislang hoechste Erzeugungsergebnis in Deutschland gefolgt von der Braunkohle und der Steinkohle. Die Stromerzeugung in Windkraftanlagen verzeichnete einen besonders starken prozentualen Zuwachs von ca. 20% auf 11,0 Mrd. kWh und ist damit zweitwichtigster regenerativer Energietraeger nach der Wasserkraft mit 25,8 Mrd. kWh. (orig.)

  8. Dauerhafte divergente Wirtschaftsentwicklungen - dargestellt am Beispiel Deutschland

    OpenAIRE

    Frohwerk, Sascha

    2010-01-01

    Die Entwicklung der deutschen Regionen nach der Wiedervereinigung kann mit Hilfe der Neuen Ökonomischen Geographie erklärt werden. Die gängigen Modelle zeigen aber weder, wie dauerhafte Lohnsatzdifferenzen ohne vollständige Agglomeration entstehen, noch wird die Frage beantwortet, in welcher der betrachteten Regionen sich eine Agglomeration bildet. Diese Lücke wird hier geschlossen, indem das Modell von Ludema und Wooton (1997) erweitert und anschließend auf die Situation in Deutschland angew...

  9. Volkswirtschaftliche Bedeutung der biobasierten Wirtschaft in Deutschland

    OpenAIRE

    Efken, Josef; Banse, Martin; Rothe, Andrea; Dieter, Matthias; Dirksmeyer, Walter; Ebeling, Michael; Fluck, Katrin; Hansen, Heiko; Kreins, Peter; Seintsch, Björn; Schweinle, Jörg; Strohm, Kathrin; Weimar, Holger

    2012-01-01

    Das Thünen-Institut wurde vom Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV) gebeten, die volkswirtschaftliche Bedeutung der biobasierten Wirtschaft in Deutschland zu kalkulieren. Grundlage bildet die vom Bioökonomierat der Bundesregierung aufgestellte Definition der biobasierten Wirtschaft als alle wirtschaftlichen Sektoren und ihre dazugehörigen Dienstleistungen, die biologische Ressourcen produzieren, be- und verarbeiten oder in irgendeiner Form nutzen. Mithi...

  10. Rezension: Die Entdeckung Deutschlands. Science-Fiction als Propaganda

    Directory of Open Access Journals (Sweden)

    Johanna Lenhart

    2015-09-01

    Full Text Available Einer der ersten und wohl eigentümlichsten deutschen Propagandafilme des Ersten Weltkriegs Die Entdeckung Deutschlands war lange verschollen. Johanna Lenhart rezensiert Britta Langes Geschichte einer filmischen Wiederentdeckung.

  11. 联邦德国早期的"一个德国"政策%,,Ein-Deutschland-Politik“ in der Frühphase der Bundesrepublik

    Institute of Scientific and Technical Information of China (English)

    朱明权

    2001-01-01

    联邦德国从成立一开始就坚持只有一个德国、联邦德国才是德意志民族的合法代表的原则,并且作出了具体努力来贯彻这一原则;此种做法在维护"一个德国"的法理和心理方面确实起到了重要的作用,一定程度上推动了德国的最终统一.

  12. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2017; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2017

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-06-14

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2017. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  13. Coal mining in the power industry of the Federal Republic of Germany in 1999; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-11-01

    After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. (orig.) [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt. (orig.)

  14. Coal mining situation in the Federal Republic of Germany. The 1st quarter 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Vierteljahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-06

    The paper reports on the coal mining in the Federal Republic of Germany in the 1st quarter of 2016. Statistical data are presented for mining, exports and imports of hard coal and lignite and for employees.

  15. Coal mining in the power industry of the Federal Republic of Germany in 2000; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt.

  16. Coal mining in the power industry of the Federal Republic of Germany in 1998; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. (orig.) [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt. (orig.)

  17. Coal mining situation in the Federal Republic of Germany. 1st half of 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Halbjahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-09-01

    The report on coal mining in Germany contains statistical data on the following issues: (a) Hard coal mining: part 1: production, resources, performance, employees; part 2: marketing and foreign commerce. (b) brown coal: part 1: production, resources, performance, employees; part II: marketing in domestic and foreign commerce.

  18. Coal mining situation in the Federal Republic of Germany. January to September 2016; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-11-16

    This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2016.

  19. Die Entwicklung der Gewaltkriminalität in der Bundesrepublik Deutschland, England/ Wales und Schweden in der zweiten Hälfte des 20. Jahrhunderts

    OpenAIRE

    Birkel, Christoph; Thome, Helmut

    2004-01-01

    Ausgangspunkt des Forschungsprojektes ist folgende empirische Beobachtung: der für verschiedene europäische Länder gut dokumentierte langfristige Rückgang der Homizidraten seit Beginn der Neuzeit bis etwa zur Mitte des 20. Jahrhunderts und ihr erneuter Anstieg in der zweiten Hälfte des vorigen Jahrhunderts. Die Autoren entwickeln einen theoretischen Ansatz, der diesen Trends zu erklären vermag. Sie gehen davon aus, dass ein solcher Ansatz aus einer Kombination bestimmter Elemente aus Elias' Z...

  20. Coal mining in the power industry of the Federal Republic of Germany in 2015; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-11-15

    The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2015. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

  1. Coal mining situation in the Federal Republic of Germany. Year 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Jahr 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-03-08

    The paper reports on the coal mining in the Federal Republic of Germany in the year 2015. Statistical data are presented for coal market, brown coal mining as well as the hard coal mining. These data consider the supply and demand of coal in Germany, and employees of the German coal industry.

  2. Coal mining situation in the Federal Republic of Germany. January to September 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-11-30

    This publication presents statistical data on hard coal mining (production, stocks, performance per miner and shift, headcount, sales, foreign sales, imports) as well as brown coal mining (production, refining, headcount, domestic sales, imports) in Germany during the period from January through September 2015.

  3. Coal mining situation in the Federal Republic of Germany. 1st half of 2015; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. 1. Halbjahr 2015

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-08-28

    The report on coal mining in Germany contains statistical data on the following issues: (a) Hard coal mining: part 1: production, resources, performance, employees; part 2: marketing and foreign commerce. (b) brown coal: part 1: production, resources, performance, employees; part II: marketing in domestic and foreign commerce.

  4. Coal mining in the power industry of the Federal Republic of Germany in 2014; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2014

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-11-15

    The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2014. Statistical data are presented for the power market and coal market, hard coal mining as well as the brown coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

  5. Coal mining in the power industry of the Federal Republic of Germany in 2010; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    The contribution under consideration reports on the coal mining in the Federal Republic of Germany in the year 2010. Statistical data are presented for the power market and coal market, brown coal mining as well as the hard coal mining. These data consider the energy consumption in Germany, power production, iron and steel production, utilization, re-cultivation and employees.

  6. Status report on the use of nuclear energy in the Federal Republic of Germany 2015; Statusbericht zur Kernenergienutzung in der Bundesrepublik Deutschland 2015

    Energy Technology Data Exchange (ETDEWEB)

    Bredberg, Ines; Hutter, Johann; Kuehn, Kerstin; Niedzwiedz, Katarzyna; Philippczyk, Frank; Thoemmes, Achim

    2016-05-15

    Status report on the use of nuclear energy in the Federal Republic of Germany 2015 covers the following topics: electricity generation on Germany, nuclear power plants in Germany, research reactors, facilities of nuclear fuel supply and nuclear waste management.

  7. Information on the situation of the German coal minig industry. January - September 1995; Zur Lage des Kohlenbergbaus in der Bundesrepublik Deutschland. Januar bis September 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-21

    The report provides up-to-date information on the German coal mining industry for the reporting time period. Data on coal mining as well as on brown coal mining cover: production, stocks, productivity, employees, sales, imports and exports of coal and coal products. (orig.) [Deutsch] Der Bericht liefert aktuelle Informationen zur Lage des deutschen Kohlenbergbaus fuer den Berichtszeitraum. Daten ueber den Steinkohlenbergbau sowie ueber den Braunkohlenbergbau geben Auskunft ueber: Produktion, Bestaende, Leistung, Beschaeftigte, Absatz, Ein- und Ausfuhr von Kohle und Kohleprodukten. (orig.)

  8. Ecology trends in Greece and in the Federal Republic of Germany. Oekologiebewegung in Griechenland und in der Bundesrepublik Deutschland; Unter Beruecksichtigung historischer, gesellschaftspolitischer und theoretischer Aspekte

    Energy Technology Data Exchange (ETDEWEB)

    Dede, I.

    1993-01-01

    This study evolves and discusses a thesis which maintains that ecology trends, both in Greece and in the Federal Republic of Germany, are the results of specific processes of social ''modernization'' based on different historical developments. A definition of ''modernization'' is given discussing the ''Fordism'' conception as part of the regulation theory: ''new'' social trends are interpreted as the results of the practice and crisis of Fordistic capitalism which, however, differs depending on its ''metropolitan'' (Germany) and ''peripheral'' (Greece) manifestations. The applicability of the Fordism theorem to Greece is discussed taking into account some political and cultural parameters. (orig.)

  9. Coal mining in the power industry of the Federal Republic of Germany in 2001; Der Kohlenbergbau in der Energiewirtschaft der Bundesrepublik Deutschland im Jahre 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    After an introductory text divided into the sections energy and coal market, coal mining and brown coal mining, extensive tables containing the most important characteristic figures of German coal mining are shown. [German] Nach einem einfuehrenden Text, der in die Abschnitte Energie- und Kohlenmarkt, Steinkohlenbergbau und Braunkohlenbergbau gegliedert ist, wird ein umfangreiches Tabellenmaterial vorgelegt, das die wichtigsten Kennzahlen des deutschen Kohlenbergbaus enthaelt.

  10. Power consumption in detail of private households in the Federal Republic of Germany 1997 - 2000. Study; Detaillierung des Stromverbrauchs privater Haushalte in der Bundesrepublik Deutschland 1997 - 2010. Studie

    Energy Technology Data Exchange (ETDEWEB)

    Boede, U.; Bradke, H.; Cremer, C.

    2000-12-01

    The study includes all electric appliances except for those used to heat rooms. 53 of these power-consuming appliances were also examined in detail as to their idle-power consumption (consumption during stand-by and apparent non-activity). The investigations covered specific performance, the typical sort of use and the development of the stocks. 1997 was used as the basic year. The development is estimated for the years 2000, 2005 and 2010. To identify the stand-by losses, the operational states were defined accurately. This makes it possible to determine which loss is caused by which operational mode. [German] Die Studie beruecksichtigt alle Elektrogeraete ausser solche fuer Raumwaerme. 53 dieser stromverbrauchenden Geraete wurden darueber hinaus bezueglich ihres Leerlaufverbrauchs (Verbrauch im Bereitschaftsbetrieb und im Schein-Aus-Zustand) detailliert betrachtet. Untersucht wurden die spezifische Leistungsaufnahme, die typische Anwendung und die Bestandsentwicklung. Als Basisjahr wurde 1997 herangezogen. Die Entwicklung wird abgeschaetzt fuer die Jahre 2000, 2005 und 2010. Zur Identifizierung der Leerlaufverluste wurde eine genaue Definition der Betriebszustaende vorgenommen. Dadurch ist es moeglich zuzuordnen, welcher Verlust auf welchen Betriebsmodus entfaellt. (orig.)

  11. Konjunktur aktuell: Zyklische Wende in Deutschland steht unmittelbar bevor

    OpenAIRE

    2002-01-01

    Das IWH nimmt die Veröffentlichung der gesamtwirtschaftlichen Ergebnisse für 2001 durch das Statistische Bundesamt zum Anlass, seine Konjunkturprognose für Deutschland und für Ostdeutschland vom Dezember 2001 für das laufende Jahr zu aktualisieren. Zugleich gibt es eine erste Vorausschätzung für das Jahr 2003 ab.

  12. Bd/s -> mu+ mu- in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00215268; The ATLAS collaboration

    2016-01-01

    The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied and new results were obtained, as presented in this talk. An upper limit is set on the Bd to mu+mu- branching ratio of BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

  13. Bd/s -> mu+ mu- in ATLAS

    CERN Document Server

    Guenther, Jaroslav; The ATLAS collaboration

    2016-01-01

    The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied to provide new results presented in this talk. An upper limit is set on the branching ratio BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

  14. Far ultraviolet spectrophotometry of BD +28 4211

    Science.gov (United States)

    Cook, Timothy A.; Cash, Webster; Green, James C.

    1991-01-01

    The results are reported of a November 1989 rocket flight which recorded a flux-calibrated spectrum of BD +28 4211 from 912 to 1150 A with 1A resolution. BD +28 4211, an SdO-type star, is commonly used as an ultraviolet calibration source in the IUE wavelength band. The present work extends the useful range of this standard shortward of Lyman-alpha. Since previous experiments show marked disparity, this study can be useful in determining a standard in the 912 to 1216 A band.

  15. 黏合剂Argaprint BD-L%Adhesive Argaprint BD-L for pigment printing

    Institute of Scientific and Technical Information of China (English)

    李正雄

    2011-01-01

    Application of Argaprint BD-L in pigment printing of cotton fabric is carried out. The results show that cotton fabric printed with Argaprint BD-L from 15% to 30% and pigment from 3% to 8% feature good color fastness and soft handle, as well as lower formaldehyde residual content less than 20 mg/kg. The application performances of Argaprint BD-L are slightly affected by fabric structure and pigment type. It can meet the requirements of high fastness printing in deep color to use Argaprint BD-L combined with cross-linking agent Argaprint CL-SLF and promoter for rubbing fastness Argaprint PF-SO.%黏合剂Argaprint BD-L系自交联型黏合剂.当涂料用量为3%~8%,即从浅色到特深色印花,黏合剂Argaprint BD-L对应的用量为15%~30%(对色浆质量),均可获得良好的牢度和柔软的手感,且布面甲醛含量小于20 mg/kg.黏合剂Argaprint BD-L与配套的交联剂Argaprint CL-SLF和摩擦牢度提升剂Argaprint PF-SO联用,可满足高牢度要求的特深色印花.

  16. 77 FR 71085 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2012-11-29

    ... serial number (S/N) Rolls-Royce Deutschland Ltd & Co KG (RRD) TAY 620- 15 turbofan engines. This AD... specified products. The MCAI states: Fan blade off on a TAY 620-15 engine has recently been reported... AD applies to Rolls-Royce Deutschland Ltd & Co KG (RRD) TAY 620-15 engines, serial numbers 17054...

  17. 78 FR 59291 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co. KG Turbofan Engines

    Science.gov (United States)

    2013-09-26

    ... Rolls-Royce Deutschland Ltd & Co. KG (RRD) Tay 620-15, 650-15, and 651- 54 turbofan engines. This... history of Tay series engines discovered that low pressure compressor (LPC) fan blade leading edge could... Rolls-Royce Deutschland Ltd & Co. KG (RRD) Tay 620-15, 650-15, and 651-54 turbofan engines. (d) Reason...

  18. 77 FR 16917 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2012-03-23

    ... ] Rolls-Royce Deutschland (RRD) Models Tay 611-8 and Tay 611-8C turbofan engines. This AD requires... Bulletin No. TAY-72-A1769, dated March 9, 2012. The actions described in this service information are...-Royce Deutschland Ltd & Co KG (RRD) turbofan engines: (1) TAY 611-8 engines, serial numbers (S/Ns) 16870...

  19. Acting jointly - with energy rationalism. The role of nuclear energy in Germany's self-commitment to reduce CO{sub 2}; Gemeinsam handeln - mit Energievernunft. Die Rolle der Kernenergie bei der Selbstverpflichtung Deutschlands zur CO{sub 2}-Minderung

    Energy Technology Data Exchange (ETDEWEB)

    Meller, E.; Hildebrand, M. [Vereinigung Deutscher Elektrizitaetswerke (VDEW) e.V., Frankfurt am Main (Germany)

    1999-11-29

    More than all the other partner states in the European Union the Federal Republic of Germany with an ambitious programme for the protection of the climate accepted the responsibility to comply with the obligations of the Kyoto Protocol to sustainably reduce the greenhouse gases. The German electricity suppliers as important players within the framework of the 'Selfcommitment of German Business on Climate Protection' never left any doubt that they would contribute their shares. At the same time great significance must be attached to the utilisation of nuclear energy. The goals of the policy for climate protection, however, would become waste paper under a withdrawal from nuclear energy as it is currently pursued by the Federal Government. (orig.) [German] Mehr als alle anderen Partnerstaaten in der Europaeischen Union hat die Bundesrepublik Deutschland mit ihrem anspruchsvollen Programm zum Schutz des Klimas Verantwortung uebernommen, den Verpflichtungen aus dem Kyoto-Protokoll nachzukommen, die Treibhausgase nachhaltig zu vermindern. Die deutschen Stromversorger als wichtiger Akteur im Rahmen der 'Selbstverpflichtung der deutschen Wirtschaft zur Klimavorsorge' haben keinen Zweifel daran gelassen, ihren Teil dazu beizutragen. Der Nutzung der Kernenergie kommt hierbei entscheidende Bedeutung zu. Mit einem Ausstieg aus der Kernenergie, wie ihn die Bundesregierung derzeit verfolgt, wuerden aber die Ziele der Klimaschutzpolitik Makulatur. (orig.)

  20. BdCESA7, BdCESA8, and BdPMT utility promoter constructs for targeted expression to secondary cell-wall-forming cells of grasses

    Directory of Open Access Journals (Sweden)

    Deborah ePetrik

    2016-02-01

    Full Text Available Utility vectors with promoters that confer desired spatial and temporal expression patterns are useful tools for studying gene and cellular function and for industrial applications. To target the expression of DNA sequences of interest to cells forming plant secondary cell walls, which generate most of the vegetative biomass, upstream regulatory sequences of the Brachypodium distachyon lignin biosynthetic gene BdPMT and the cellulose synthase genes BdCESA7 and BdCESA8 were isolated and cloned into binary vectors designed for Agrobacterium-mediated transformation of monocots. Expression patterns were assessed using the β-glucuronidase gene GUSPlus and X-glucuronide staining. All three promoters showed strong expression levels in stem tissue at the base of internodes where cell wall deposition is most active, in both vascular bundle xylem vessels and tracheids, and in interfascicular tissues, with expression less pronounced in developmentally older tissues. In leaves, BdCESA7 and BdCESA8 promoter-driven expression was strongest in leaf veins, leaf margins, and trichomes; relatively weaker and patchy expression was observed in the epidermis. BdPMT promoter-driven expression was similar to the BdCESA promoters expression patterns, including strong expression in trichomes. The intensity and extent of GUS staining varied considerably between transgenic lines, suggesting that positional effects influenced promoter activity. Introducing the BdPMT and BdCESA8 Open Reading Frames (ORFs into BdPMT and BdCESA8 utility promoter binary vectors, respectively, and transforming those constructs into Brachypodium pmt and cesa8 loss-of-function mutants resulted in rescue of the corresponding mutant phenotypes. This work therefore validates the functionality of these utility promoter binary vectors for use in Brachypodium and likely other grass species. The identification, in Bdcesa8-1 T-DNA mutant stems, of an 80% reduction in crystalline cellulose levels

  1. 75 FR 66657 - Airworthiness Directives; Eurocopter Deutschland GmbH Model MBB-BK 117 C-2 Helicopters

    Science.gov (United States)

    2010-10-29

    ... separation of dynamic weights, severe vibration, and subsequent loss of control of the helicopter. Actions... Deutschland GmbH Model MBB- BK 117 C-2 Helicopters AGENCY: Federal Aviation Administration, DOT. ACTION: Final... Deutschland GmbH (ECD) Model MBB BK 117 C-2 helicopters. This amendment results from a mandatory...

  2. Widespread occurrence of bd in French Guiana, South America.

    Science.gov (United States)

    Courtois, Elodie A; Gaucher, Philippe; Chave, Jérôme; Schmeller, Dirk S

    2015-01-01

    The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1) determine its geographical distribution, (2) test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera) to define sentinel species for future work, (3) track changes in prevalence through time and (4) determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012). At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4%) as compared to Bufonidae (2.6 %) and Hylidae (1.5%). In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

  3. Widespread occurrence of bd in French Guiana, South America.

    Directory of Open Access Journals (Sweden)

    Elodie A Courtois

    Full Text Available The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1 determine its geographical distribution, (2 test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera to define sentinel species for future work, (3 track changes in prevalence through time and (4 determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012. At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4% as compared to Bufonidae (2.6 % and Hylidae (1.5%. In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

  4. Energy for Germany 2000. Facts, views and positions in a global trend. Goals of the global and national policies in the 21st century: Competitive strength, assured supply, environmental compatibility; Energie fuer Deutschland 2000. Fakten, Perspektiven und Positionen im globalen Kontext. Schwerpunktthema 'Ziel globaler und nationaler Energiepolitik im 21. Jahrhundert: Wettbewerbsfaehig - versorgungssicher - umweltvertraeglich'

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The publication is based on the publication 'Energy for Tomorrow's World - Acting Now.', which was published by the World Energy Council in 2000. It presents an analysis of the current situation and contains suggestions for actions that should be taken in the period up to 2020. While national energy policy will still be required, it can only be successful if global aspects are not neglected. This includes the consideration of the responsibility of the industrial nations for third world countries. The energy concept presented here intends to take account of the decisive global aspects. [German] Die Darstellung der globalen Aspekte stuetzt sich auf die Standortbestimmung 2000 des Weltenergierates 'Energy for Tomorrow's World - Acting Now.'. Diese Standortbestimmung unterzieht die Anfang der 90er Jahre erschienene globale Studie des Weltenergierates einer kritischen Ueberpruefung, stellt Abweichungen von den damals angenommenen Entwicklungsperspektiven fest und gibt vor allem konkrete Handlungsempfehlungen fuer die Zeit bis zum Jahr 2020, also fuer die Zeitspanne, die konkret ueberschaubar und gestaltbar ist. Die neue Standortbestimmung des Weltenergierates unterstreicht, dass nationale Energiepolitik zwar weiterhin notwendig ist, aber nur dann auf Dauer erfolgreich sein wird, wenn sie auf diese globalen Aspekte ausgerichtet ist. Dazu gehoert auch, dass westliche, entwickelte Laender sich bewusst sind, dass eine nationale Energiepolitik zu Lasten der Dritten Welt nicht nur keine Zukunft hat, sondern vor allem nicht zu verantworten ist. Dies gilt natuerlich ebenso fuer die Umweltpolitik. An diesen Massstaeben wird sich auch das konkrete Energiekonzept messen lassen muessen, das nun fuer die Bundesrepublik Deutschland auf der Basis des 'Energiedialogs 2000' erarbeitet werden soll. Mit der hier vorgelegten Publikation will das Deutsche Nationale Komitee des Weltenergierates dazu beitragen, dass in diesem Energiekonzept die

  5. Wormhole solution of BD theory in an anisotropic radiation background

    Directory of Open Access Journals (Sweden)

    B. Nasre Esfahani

    2001-06-01

    Full Text Available   Time-dependent wormhole solution of the BD theory in an anisotropic radiation background is presented. It is also found that the BD scalar field depends only on time. This time dependency is in power-law form. It is shown that the wormhole geometry is valid for ω ≥ -3/2, and for any arbitrary positive values of . The GR limit of our solution is obtained for ω=0 , not for ω→∞ . Though the BD field can be non-exotic, the background material is entirely exotic.

  6. Pluralistic heat supply concept. Strategies and technologies for decentralised district heating in a liberalized energy market with an emphasis on CHP technology and renewable energies. AGFW principal study, first part of work. Vol. 2. Part 1: District heating systems, existing stock of buildings. Part 2: Technology development and assessment; Pluralistische Waermeversorgung. Strategien und Technologien einer pluralistischen Fern- und Nahwaermeversorgung in einem liberalisierten Energiemarkt unter besonder Beruecksichtigung der Kraft-Waerme-Kopplung und regenerativer Energien. AGFW-Hauptstudie. 1. Bearbeitungsabschnitt. Bd. 2. T. 1: Waermeversorgung des Gebaeudebestandes. T. 2: Technologieentwicklung und -bewertung

    Energy Technology Data Exchange (ETDEWEB)

    Neuffer, H.; Witterhold, F.G. [Arbeitsgemeinschaft Fernwaerme e.V., Frankfurt am Main (Germany); Pfaffenberger, W. [Bremer Energie Institut, Bremen (DE)] [and others

    2001-08-01

    In order to prepare the basis for the comparative analysis of various carbon dioxide mitigation policies in terms of energy performance of buildings, economic efficiency and ecologic benefits, the wide variety of community district heating services is defined in part A, based on a very differential and extensive characterisation of selected dwellings and the building types. The last chapter of part A discusses the impacts of an enhanced CHP electricity production on the energy system of the Federal Republic of Germany. Part B explains the basic aspects and the approaches used for a building-specific modelling of the various structures of dwellings and the further development of methods applied for energy analysis and energy system modelling at the national level. (orig./CB) [German] Zur Vorbereitung des energetischen, oekonomischen und oekologischen Vergleichs verschiedener CO{sub 2}-Minderungsmassnahmen werden zunaechst in Teil A die unterschiedlichen Versorgungsaufgaben kommunaler Fernwaermeversorgungssysteme anhand einer sehr differenzierten und umfangreichen Charakterisierung der ausgewaehlten Siedlungs- und Gebaeudestrukturen definiert. Im letzten Kapitel von Teil A werden ausserdem die Rueckwirkungen einer verstaerkten KWK-Stromerzeugung auf das Energiesystem der Bundesrepublik Deutschland diskutiert. Teil B erlaeutert die Grundlagen und die Entwicklung der gebaeudescharfen Modellierung von Siedlungsstrukturen und eine Weiterentwicklung von Energiesystemmodellen. (orig./CB)

  7. Environmental radioactivity in Germany. Report of the federal installations and the Federal office of radiation protection. Data and evaluation; Umweltradioaktivitaet in der Bundesrepublik Deutschland. Bericht der Leitstellen des Bundes und des Bundesamtes fuer Strahlenschutz. Stand 2014. Daten und Bewertung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-04-15

    This report is a compilation and evaluation of data on radioactivity in the environment and in the vicinity of nuclear facilities in Germany from 2011 to 2013. The mean radiation exposure of the public in Germany was about 4.0 mSv in 2013, of which natural radiation exposure accounted for about 2.1 mSv and man-made radiation exposure for 1.9 mSv. An international work group is in charge of the preparation of quality standards for radon measurements. These latter also serve as a basis to implement the regulations of the new EURATOM Basic Safety Standards Directive. Rice grown within the contaminated zone around Fukushima has been certified as reference material for food monitoring. The trace analysis laboratory for airborne radioactive substances obtained several striking results of measurements performed during the reporting period. Man-made radionuclides from the Fukushima nuclear accident were detectable, too. Assessment of anthropogenic radioactivity also requires thorough measurement of ''natural'' radiation components. Three different measurement areas are used as a reference for calibration. Discharges of radioactive substances into the exit air and wastewaters from nuclear power plants remained far below the authorised limit from 2011 to 2013. There has been a trend of decreasing discharges since 1975. The nine nuclear power plant units in operation at the end of the reporting period had a total capacity of 12.7 GW and accounted for 15 per cent of power generation. The annual mean values provided by the measuring network of the Deutscher Wetterdienst (DWD; German Meteorological Service) amounted to 0.6 mBq/m{sup 3}, 0.7 mBq/m{sup 3} and 0.7 mBq/m{sup 3} for the total -activity in the air and 58 Bq/m{sup 2}, 38 Bq/m{sup 2}, and 27 Bq/m{sup 2} for the total -activity deposited by precipitation in 2011, 2012 and 2013, respectively. The higher annual value for 2011 is due to the Fukushima releases. The activity concentrations of {sup 85}Kr measured by the BfS in Freiburg remained at about 1.5 Bq/m{sup 3}. The measured activity concentrations of {sup 133}Xe ranged from one to 100 mBq/m{sup 3}, except for the time after the Fukushima disaster. Almost all measured values of {sup 137}Cs concentrations in drinking water and groundwater are below the detection limit The BfS, in cooperation with the PTB, carried out interlaboratory comparisons to determine natural radionuclides in drinking water in 2012 and 2014. In the North Sea sampling was performed every August. The {sup 137}Cs activity concentration ranged from 1.3 Bq/m{sup 3} in the Elbe estuary up to 3.0 Bq/m{sup 3} in the outer German Bight. Compared to this, the {sup 137}Cs activity concentration in the Baltic Sea is higher, ranging from 20 Bq/m{sup 3} in the western part, to 34 Bq/m{sup 3} in the eastern part of the region under study, as a result of the Chernobyl reactor accident. Consequently, the measured {sup 137}Cs activity concentrations in fish are also higher in the Baltic Sea than in the North Sea, reaching up to 11 Bq/kg during the reporting period. Increased activity concentrations are still being measured in fish from inland waters, especially from lakes. In Southern Germany, these have declined from more than 200 Bq/kg moist mass in 1986 down to 2.3 Bq/kg up to now. As a result of the Fukushima nuclear disaster, more than 10 PBq of {sup 134}Cs and {sup 137}Cs (1 PBq = 1015Bq) entered the Pacific Ocean every. While soil contamination with {sup 137}Cs is due to the Chernobyl accident, most of the {sup 90}Sr deposits go back to the time of the atmospheric nuclear weapons tests. In feedstuffs, mean values ranging from < 0.1 Bq/kg up to 0.8 Bq/kg were measured for {sup 137}Cs and from 0.1 Bq/kg up to 2.3 Bq/kg for {sup 90}Sr. Contamination of milk constantly remains at a low level. Dietary intake of {sup 137}Cs and 90Sr was 73 Bq and 29 Bq, respectively, on average in 2013. An interlaboratory comparison involving 72 institutions from Germany and neighbouring countries was carried out to determine the levels of {sup 40}K, {sup 89}Sr, {sup 90}Sr, {sup 131}I, Ba-133, {sup 134}Cs, and {sup 137}Cs in raw milk. More than 94 per cent of the measurement results obtained for all nuclides were within the allowed range of dispersion. Apart from {sup 131}I, which was detected in many samples of fly ash/filter dust and is assumed to originate from nuclear medicine applications, {sup 137}Cs from the Chernobyl accident was still detectable. Mean values of 14 Bq/kg of dry matter were measured in clearing sludge in Southern Bavaria. {sup 134}Cs from the Fukushima accident was also detectable temporarily in 2011. As a consequence of the Chernobyl accident, the {sup 137}Cs activity concentration was found to be enhanced in samples of plants used to make pharmaceuticals or tea still in 2013. Buckbean leaves from Poland had 35 Bq/kg of dry matter, and Iceland moss from Russia 15 Bq/kg of dry matter.

  8. Results of a study on low-level flight noise in the Federal Republic of Germany. Acute and chronic effects on human hearing. Ergebnisse einer Tieffluglaerm-Studie in der Bundesrepublik Deutschland. Akute und chronische Auswirkungen auf das menschliche Gehoer

    Energy Technology Data Exchange (ETDEWEB)

    Ising, H.; Rebentisch, E. (BGA, Berlin (Germany). Inst. fuer Wasser-, Boden- und Lufthygiene)

    1992-03-01

    In persons aged 18 to 50, hearing thresholds after exposure to low-level flight noise with different noise levels and speeds of noise levels and speeds of noise level increase were determined within a broad frequency range by means of fixed-frequency Bekesy audiometry. Temporary rises in the hearing threshold were shown to occurr significantly more often for rapid increases in noise level than for slow ones. A pilot study conducted in 1985 aimed at the following; Comparison of school children from an extremely afflicted area of the zone of flight altitude 75 metres with school children from a zone of flight altitude 150 metres as to hearing symptoms and auditory capability. These results were to be verified and extended by the principal study. Representative field studies were carried through for this purpose in Lower Saxonia. The results obtained corroborate the hypothesis that military low-level flight noise with noise peaks around 125 dB (A) and high speed of noise level increase causes slight, irreversible threshold of hearing shifts in sensitive individuals of the population concerned. (orig./MM).

  9. Lehrer in der Bundesrepublik Deutschland. Eine Kritische Analyse Statistischer Daten uber das Lehrpersonal an Allgemeinbildenden Schulen. (Education in the Federal Republic of Germany. A Statistical Study of Teachers in Schools of General Education.)

    Science.gov (United States)

    Kohler, Helmut

    The purpose of this study was to analyze the available statistics concerning teachers in schools of general education in the Federal Republic of Germany. An analysis of the demographic structure of the pool of full-time teachers showed that in 1971 30 percent of the teachers were under age 30, and 50 percent were under age 35. It was expected that…

  10. Sales controlling comes into view. MIS (management information system) Deutschland GmbH fits energy suppliers; Vertriebscontrolling in Sicht. MIS Deutschland GmbH macht Energieversorger fit

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2002-03-01

    MIS has integrated Microsoft-Excel efficiently, so appliers must not change other systems, can utilize advantages and know how and further functionalities like optimization of planning processes, automation of data processing, generation of a data base with structured information of energy data are available for customers.(GL) [German] Die MIS Deutschland GmbH wurde 1988 gegruendet. Die Gruender waren Studenten der Universitaet Darmstadt. Einer von ihnen ist noch heute Vorstandsvorsitzender der MIS AG. Schon damals hatte man die Vision, Manager oder die Entscheidungstraeger in Unternehmen mit Informationen zu versorgen und in die Lage zu versetzen, diese auch nach ihren Beduerfnissen auswerten, analysieren und reporten zu koennen. Dadurch entstand 1988 in Zusammenarbeit mit Microsoft die erste Microsoft-Excel-Konferenz in Deutschland. MIS hat Microsoft-Excel leistungsfaehig integriert, sodass der Anwender nicht auf ein anderes System umlernen muss, sondern die Vorteile und das Know-how Weiterverwenden kann und zusaetzlich weitere Funktionalitaeten zur Verfuegung gestellt bekommt. (orig.)

  11. 78 FR 52410 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Science.gov (United States)

    2013-08-23

    ..., separation of tail rotor parts, severe vibration, and subsequent loss of control of the helicopter. DATES... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY..., MBB-BK 117 B-1, MBB-BK-117 B-2, and MBB-BK 117 C-1 helicopters to require inspections for corrosion...

  12. 77 FR 52265 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Science.gov (United States)

    2012-08-29

    ... rotor parts, severe vibration, and subsequent loss of control of the helicopter. You may obtain further... vibration, and subsequent loss of control of the helicopter. (c) Compliance You are responsible for... Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ] ACTION: Notice of...

  13. 77 FR 67582 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2012-11-13

    ... directive (AD) for certain Rolls-Royce Deutschland Ltd & Co KG (RRD) Tay 611-8 turbofan engines. This... issued Alert Service Bulletin TAY-72-A1696, Revision 1, dated June 11, 2012. The actions described in... Ltd & Co KG (RRD) Tay 611-8 turbofan engines, serial numbers 16245, 16256, 16417, 16418, 16584, 16585...

  14. 78 FR 17075 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2013-03-20

    ... Ltd & Co KG (RRD) Tay 611-8 turbofan engines. This AD requires inspection and replacement, if... ADs None. (c) Applicability This AD applies to Rolls-Royce Deutschland Ltd & Co KG (RRD) Tay 611-8... Agency AD 2012-0163, dated August 28, 2012, and RRD Alert Service Bulletin TAY-72-A1696, Revision 1...

  15. 77 FR 20321 - Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters

    Science.gov (United States)

    2012-04-04

    ... anyone being lifted in the rescue hoist. Related Service Information ECD has issued Emergency Alert... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; Eurocopter Deutschland GmbH Helicopters AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of...

  16. Vom Bürger zum Kunden. Der Strukturwandel des Bildungssystems und der demokratischen Kultur in Deutschland

    OpenAIRE

    Zymek, Bernd

    2004-01-01

    Der Artikel analysiert aus einer bildungs- und sozialhistorischen Perspektive die Ursachen und Konsequenzen des auffälligen Begriffswandels und Strategiewechsels in den bildungspolitischen Debatten Deutschlands. die aktuelle Konjunktur ökonomischer Begriffe und betriebswirtschaftlicher Strategien wird im Zusammenhang des langfristigen Strukturwandels des deutschen Bildungssystems, des Funktionsverlusts des Berechtigungswesens und der Expansion kommerzieller Bildungsangebote im Umfeld des staa...

  17. Measurement of the B$_{d}^{0}$ meson oscillation frequency

    CERN Document Server

    Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Fernández, D; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Korolko, I; Koutsenko, V F; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino

    1996-01-01

    Time-dependent \\Bd-\\Bbd\\ mixing is studied using 1.5 million hadronic Z decays collected by L3. Semileptonic B decays are selected by requiring at least one reconstructed lepton in both thrust hemispheres. Charge correlations between the tagged leptons are studied as a function of proper time. The proper time of the b-hadron decay is measured by reconstructing the production and decay vertices using a silicon microvertex detector. The measured \\Bd\\ meson oscillation frequency corresponds to a mass difference \\Dmd\\ between the two \\Bd\\ mass eigenstates of \\begin{displaymath} \\Dmd = \\left( 0.496 ^{+ 0.055}_{- 0.051}\\ \\mathrm{(stat)} \\pm{ 0.043}\\ \\mathrm{(syst)} \\right)\\ \\mathrm{ps}^{-1}. \\end{displaymath}

  18. Reseña-ensayo

    OpenAIRE

    Arrizabalaga, Jon

    1987-01-01

    MEDIZIN und soziale kontrolle. Zum verhältnis von sozialgeschichte und sociologie der medizin am beispiel neuerer literatur aus des bundesrepublik Deutschland. Mit einem Exkurs : Neuere Forschyngen zur Medizin im Nationalsozialismus

  19. Germania Quo Vadis?: Dynamics of Change in German Security Policy

    Science.gov (United States)

    2007-06-01

    détente imperatives of Willy Brandt in the late 1960’s. These factors of policy operated to best effect in 1989-1991, but have become more problematic in...Hacke, Die Aussenpolitik der Bundesrepublik Deutschland. Von Konrad Adenauer bis Gerhard Schroeder (Berlin: Ullstein Verlag, 2004, Second Edition), 66...Bundesrepublik Deutschland. Von Konrad Adenauer bis Gerhard Schroeder (Berlin: Ullstein Verlag, 2004, Second Edition), 69. 9 West German population wary

  20. Hydro power in the German system of energy supply; Wasserkraft im Energiesystem Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Kaltschmitt, M. [Stuttgart Univ. (Germany). Abt. Neue Energietechnologie und Technikanalyse

    1997-12-31

    The technical potentials of electric power generation from hydro power in Germany, the current harnessing of hydro power, its costs, and certain characteristic quantities reflecting its effects on the environment are described. These diverse characteristic quantities are compared with those of other renewable and fossil energy sources used to generate electricity. On this basis, opportunities for extending the use of hydro power in Germany and its limits are discussed. (orig.) [Deutsch] Das Ziel der folgenden Ausfuehrungen ist, die technischen Potentiale und deren derzeitige Nutzung, die Kosten und bestimmte die Umwelteffekte beschreibende Kenngroessen einer Stromerzeugung aus Wasserkraft in Deutschland darzustellen. Diese unterschiedlichen Kenngroessen werden anschliessend mit denen anderer regenerativer Energien und fossiler Energietraeger zur Stromerzeugung verglichen. Ausgehend davon werden die Moeglichkeiten und Grenzen einer weitergehenden Wasserkraftnutzung im Energiesystem Deutschland diskutiert. (orig.)

  1. "Der Islam" in Deutschland. Transformationsprozesse muslimischer Religiosität in der Diaspora

    OpenAIRE

    Noormann, Harry

    2006-01-01

    Der Autor stellt vor dem Hintergrund einer religionswissenschaftlichen Migrationsforschung die historisch gewachsene Bedeutung des Islams in Deutschland dar. Dabei kommen Möglichkeiten und Grenzen von Transkulturalität in den Blick. (DIPF/Orig.) The author presents the historically growing importance of the Islam in Germany with the background of a migration research on religious science. Thereby, chances and limits of transculturality come into focus. (DIPF/Orig.)

  2. Wirkungen aktiver Arbeitsmarktpolitik: Evaluierungsergebnisse für Deutschland, Schweden, Dänemark und die Niederlande

    OpenAIRE

    Rabe, Birgitta

    2000-01-01

    Hohe Teilnehmerzahlen sowie ein beträchtlicher Mitteleinsatz für arbeitsmarktpolitische Maßnahmen haben in den letzten Jahren zu einem gesteigerten Interesse an den Wirkungen aktiver Arbeitsmarktpolitik geführt. In dieser Literaturstudie wird daher danach gefragt, was sich nach dem aktuellen Stand der Evaluierungsforschung über die bisherige Wirksamkeit aktiver Arbeitsmarktpolitik in Deutschland sagen lässt. Welche Instrumente funktionieren für welche Personengruppen und welche Maßnahmengesta...

  3. Die Liberalisierung de Telekommunikationsbranche in Deutschland( The Liberalization of the Telecommunication-Industry in Germany)

    Science.gov (United States)

    2004-03-01

    Foreign Direct Investment , Production, and Welfare, No. 11 (June 2003). o Dewenter, Ralf, The Economics of Media Markets, No. 10 (June 2003). o Josten...liberalization-measures are described and are analyzed their effects on the different markets. While the competition in the markets for fine - and foreign ...Elektrizitdits- sektor in Deutschland), oder aber die Leistungen sind direkt staatlich erbracht worden (wie im Bereich der Telekommunikation), wobei das

  4. 78 FR 71532 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2013-11-29

    ...- 02 for all Rolls-Royce Deutschland (RRD) Tay 620-15, Tay 650-15, and Tay 651-54 turbofan engines. AD... on certain serial number (S/N) Tay 650-15 engines. AD 2007-03-02 also requires, for all Tay 611-8, 620-15, Tay 650-15, and Tay 651-54 engines, initial and repetitive UIs of LP compressor fan blades. AD...

  5. 77 FR 74123 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG Turbofan Engines

    Science.gov (United States)

    2012-12-13

    ... Rolls-Royce Deutschland Ltd & Co KG (RRD) models Tay 620-15 and Tay 650-15 turbofan engines. This... correct an unsafe condition for the specified products. The MCAI states: The Tay 650-15 and Tay 650-15/10... assemblies installed in Tay 650-15 and Tay 650-15/10 engines as well as in Tay 620-15 and Tay 620-15/20...

  6. Studie über die Erzeugungs- und Vermarktungsstruktur des Bienenzuchtsektors in Deutschland

    OpenAIRE

    Efken, Josef; Bernhardt, Angelina

    2016-01-01

    Die Studie hat zum Ziel, einen Überblick über den deutschen Markt für Honig zu geben. Es werden die Imkereistruktur und die Beziehungen zwischen den Marktpartnern dargestellt. Daneben werden die Versorgungsbilanz sowie die Nachfrage betrachtet, bei der Deutschland als einer der größten Konsumenten auch weltweit eine entscheidende Rolle spielt. Zu unterscheiden sind hierbei Honige, die via Direktvermarktung vom Imker vertrieben werden, und Honige aus dem Einzelhandel. Diese Segmente existieren...

  7. Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

    Directory of Open Access Journals (Sweden)

    Wanyi Li

    2014-03-01

    Full Text Available Influenza (flu pandemics have exhibited a great threat to human health throughout history. With the emergence of drug-resistant strains of influenza A virus (IAV, it is necessary to look for new agents for treatment and transmission prevention of the flu. Defensins are small (2–6 kDa cationic peptides known for their broad-spectrum antimicrobial activity. Beta-defensins (β-defensins are mainly produced by barrier epithelial cells and play an important role in attacking microbe invasion by epithelium. In this study, we focused on the anti-influenza A virus activity of mouse β-defensin 1 (mBD1 and β defensin-3 (mBD3 by synthesizing their fusion peptide with standard recombinant methods. The eukaryotic expression vectors pcDNA3.1(+/mBD1-mBD3 were constructed successfully by overlap-PCR and transfected into Madin-Darby canine kidney (MDCK cells. The MDCK cells transfected by pcDNA3.1(+/mBD1-mBD3 were obtained by G418 screening, and the mBD1-mBD3 stable expression pattern was confirmed in MDCK cells by RT-PCR and immunofluorescence assay. The acquired stable transfected MDCK cells were infected with IAV (A/PR/8/34, H1N1, 0.1 MOI subsequently and the virus titers in cell culture supernatants were analyzed by TCID50 72 h later. The TCID50 titer of the experimental group was clearly lower than that of the control group (p < 0.001. Furthermore, BALB/C mice were injected with liposome-encapsulated pcDNA3.1(+/mBD1-mBD3 through muscle and then challenged with the A/PR/8/34 virus. Results showed the survival rate of 100% and lung index inhibitory rate of 32.6% in pcDNA3.1(+/mBD1-mBD3group; the TCID50 titer of lung homogenates was clearly lower than that of the control group (p < 0.001. This study demonstrates that mBD1-mBD3 expressed by the recombinant plasmid pcDNA3.1(+/mBD1-mBD3 could inhibit influenza A virus replication both in vitro and in vivo. These observations suggested that the recombinant mBD1-mBD3 might be developed into an agent for

  8. Characterization of Phosphate Transporters BdPT4 and BdPT8 in Mycorrhizal and Non-Mychorrhizal Brachypodium distachyon

    DEFF Research Database (Denmark)

    Clausen, Signe Sandbech

    was observed in non-arbusculated cells of AM plants. In arbusculated cells, BdPT8 was detected in the ER while BdPT4 was localized to the plasma membrane and the periarbuscular membrane (PAM) surrounding the arbuscular trunk and thick branches, which further supported a role of both BdPTs in direct Pi uptake......PT proteins were expressed in cells where direct PTs are believed to perform their function, as well as in the vascular tissue. In NM plants, BdPT4 was localized to the plasma membrane whereas BdPT8 accumulated in the endoplasmic reticulum (ER) in the secretory pathway. A similar expression pattern......, and for BdPT4 in AM-mediated Pi uptake as well. In conclusion, the studies suggest that BdPT4 and possibly also BdPT8 are involved in direct uptake as well as in translocation of Pi in B. distachyon. Interestingly, as BdPT4 was additionally localised to the PAM of arbusculated cells, BdPT4 may also...

  9. Photometry and Spectroscopy of BD+35 1111 in M38

    Science.gov (United States)

    Souza, Steven P.; Kwitter, Karen B.; Sami, Mona; Beltz-Mohrmann, Gillian

    2014-06-01

    BD+35 1111 is a ~10.5-magnitude star in the field of M38, an open cluster that has been a target of our ongoing study of Hα emission variability in massive stars via narrowband CCD photometry (e.g. Souza, Davis, and Teich 2013, BAAS. 45, PM354.22). BD+35 1111 has no MKK classification in the literature, and is not listed as variable in GCVS, VSX, or NSVS. It is included, with no further characterization, in both the Vatican and Kohoutek catalogs of emission line stars. Using inhomogeneous ensemble photometry (e.g. Bhatti, Richmond, Ford, and Petro 2010, ApJ Supp., 186, 233), we find it to be an irregular variable with a range of ~0.15 mag. To further understand this star we obtained a medium-resolution spectrum using the DIS spectrograph on the ARC 3.5-meter telescope at Apache Point Observatory. We classify BD+35 1111 as B2Ve, the only confirmed Be star in the field of M38. This raises the question of membership, since the age of M38 is likely 250 Ma or greater (Pandey et al. 2007, Publ. Astron. Soc. Japan 59, 547). From published B and V magnitudes we find a nominal distance to BD+35 1111 of 1.6 kpc, but with a range of 1.3 to 2.0 kpc, marginally consistent with distance estimates for M38 ranging from 1.0 to 1.4 kpc. If a member, BD+35 1111 is a candidate blue straggler. If not, it may have escaped from a nearby younger cluster, possibly Kronberger 1 (Kronberger et al. 2006, A&A 447, 921), which has the right heliocentric distance and age. The notion that BD+35 1111 is behind M38 is supported by its reddening of EB-V ~ 0.5, significantly higher than for M38 itself 0.24). We gratefully acknowledge support for student research from NSF grant AST-1005024 to the Keck Northeast Astronomy Consortium, Williams College, and NASA via an American Astronomical Society Small Research Grant.

  10. Germany: primary energy consumption in 2002; Primaerenergieverbrauch in Deutschland 2002

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2003-03-01

    The consumption of primary energy in Germany in 2002 has declined clearly compared to the level in the year before. It amounted to 487.8 million TCE, which is 1.9% less than the 498.5 million TCE of 2001. The development is mainly due to the economic slump and to the milder weather, with higher ambient temperatures, than in 2001. On the basis of 0.2% overall economic growth, the energy productivity of the economy improved by 0.8%. It was clearly lower than over the average of the period 1991 to 2001, where it had been 1.4%. Unlike the consumption of primary energy, gross electricity consumption increased slightly along with the gross domestic product, reaching approx. 582,0 billion kWh, which is approx. 1 billion kWh above the approx. 581.0 billion kWh of 2001. While 2001 still showed an export balance of approx. 1.3 billion kWh, 2002 shows an import balance of 0.7 billion kWh. After a clear drop in the second half of 2001, oil prices picked up in 2002, especially as a result of the threat of a war in Iraq. The world market price of (Brent) crude oil was approx. 55% higher in December 2002 than it had been in late 2001; the shift in the Euro-Dollar exchange rate in favor of the Euro reduced this impact on import prices to a level of approx. +33%. Unlike oil, the import prices of natural gas were lower than those in 2001 throughout the past year. Also the prices of imported coal dropped significantly. Electricity prices continued to rise sharply, partly also as a consequence of energy policy measures. (orig.) [German] Der Primaerenergieverbrauch in Deutschland ist im Jahre 2002 gegenueber dem Vorjahr deutlich gesunken. Er lag mit 488,5 Mio. t SKE um 1,9% niedriger als 2001 mit 497,8 Mio. t. SKE. Diese Entwicklung ist im Wesentlichen auf die schwache Konjunktur und auf die gegenueber 2001 mildere Witterung mit hoeheren Umgebungstemperaturen zurueckzufuehren. Die Energieproduktivitaet der Volkswirtschaft hat sich bei einem gesamtwirtschaftlichen Wachstum von 0,2% im

  11. Protection of the climate in Germany. Second report presented by the Government of the Federal Republic of Germany according to the United Nations Agreement on Climatic Changes; Klimaschutz in Deutschland. Zweiter Bericht der Regierung der Bundesrepublik Deutschland nach dem Rahmenuebereinkommen der Vereinten Nationen ueber Klimaaenderungen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report is the second government report after the climate convention. It contains an inventory of emissions of relevance for the greenhouse effect and the states where they are stored (forest) plus a description of the government`s preventive measures to protect the climate. You can find emission scenarios and the projection to the years 2000, 2005, 2010 and 2020 and an assessment of the effects of the measures. (orig./SR)

  12. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Chesley, Steven R.; Mommert, Michael; Hora, Joseph L.; Farnocchia, Davide; Trilling, David E.; Vokrouhlický, David; Mueller, Michael; Harris, Alan W; Smith, Howard Alan; Fazio, Giovanni G.

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009 BD, which is a candidate target of the NASA Asteroid Robotic Retrieval Mission (ARRM). The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational pertur

  13. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Farnocchia, D.; Mommert, M.; Hora, J. L.; Chesley, S. R.; Vokrouhlický, D.; Trilling, D. E.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.; Knežević, Zoran; Lemaitre, Anne

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009~BD, which is a candidate target of the NASA Asteroid Redirect Mission. The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational perturbations, such as

  14. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Chesley, Steven R.; Mommert, Michael; Hora, Joseph L.; Farnocchia, Davide; Trilling, David E.; Vokrouhlický, David; Mueller, Michael; Harris, Alan W; Smith, Howard Alan; Fazio, Giovanni G.

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009 BD, which is a candidate target of the NASA Asteroid Robotic Retrieval Mission (ARRM). The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational

  15. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Farnocchia, D.; Mommert, M.; Hora, J. L.; Chesley, S. R.; Vokrouhlický, D.; Trilling, D. E.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.; Knežević, Zoran; Lemaitre, Anne

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009~BD, which is a candidate target of the NASA Asteroid Redirect Mission. The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational perturbations, such as

  16. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 1: results and summary overview; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 1: Ergebnisse und zusammenfassende Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Kruse, H.; Schramm, E.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  17. A Gamma Doradus Candidate In Eclipsing Binary BD And?

    CERN Document Server

    Sipahi, E

    2013-01-01

    The BVR photometric light curves of the eclipsing binary BD And were obtained in 2008 and 2009. We estimated the mass ratio of the system as 0.97 and the photometric solutions were derived. The results show that BD And is a detached binary system, whose components have a little temperature difference of about 40 K. By analyzing photometric available light minimum times, we also derived an update ephemeris and found for the first time a possible periodic oscillation with an amplitude of 0.011 days and a period of 9.6 years. The results indicate that the periodic oscillation could be caused by a third component physically attached to the eclipsing binary. After removing the light variations due to the eclipses and proximity effects, the light-curve distortions are further explained by the pulsation of the primary component with a dominant period of 1 day. In accordance with the position of the primary component on the Hertzsprung-Russell diagram and its pulsation period, the primary component of BD And could be...

  18. 78 FR 75511 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

    Science.gov (United States)

    2013-12-12

    ... design feature associated with control surface awareness and mode annunciation of the electronic flight... airplanes will incorporate the following novel or unusual design features: A fly-by-wire electronic flight... Inc., Models BD-500-1A10 and BD- 500-1A11 Series Airplanes; Electronic Flight Control System:...

  19. High Production of 2,3-Butanediol (2,3-BD) by Raoultella ornithinolytica B6 via Optimizing Fermentation Conditions and Overexpressing 2,3-BD Synthesis Genes

    Science.gov (United States)

    Kim, Taeyeon; Cho, Sukhyeong; Lee, Sun-Mi; Woo, Han Min; Lee, Jinwon; Seo, Jin-Ho

    2016-01-01

    Biological production of 2,3-butandiol (2,3-BD) has received great attention as an alternative to the petroleum-based 2,3-BD production. In this study, a high production of 2,3-BD in fed-batch fermentation was investigated with a newly isolated bacterium designated as Raoultella ornithinolytica B6. The isolate produced 2,3-BD as the main product using hexoses (glucose, galactose, and fructose), pentose (xylose) and disaccharide (sucrose). The effects of temperature, pH-control schemes, and agitation speeds on 2,3-BD production were explored to optimize the fermentation conditions. Notably, cell growth and 2,3-BD production by R. ornithinolytica B6 were higher at 25°C than at 30°C. When three pH control schemes (no pH control, pH control at 7, and pH control at 5.5 after the pH was decreased to 5.5 during fermentation) were tested, the best 2,3-BD titer and productivity along with reduced by-product formation were achieved with pH control at 5.5. Among different agitation speeds (300, 400, and 500 rpm), the optimum agitation speed was 400 rpm with 2,3-BD titer of 68.27 g/L, but acetic acid was accumulated up to 23.32 g/L. Further enhancement of the 2,3-BD titer (112.19 g/L), yield (0.38 g/g), and productivity (1.35 g/L/h) as well as a significant reduction of acetic acid accumulation (9.71 g/L) was achieved by the overexpression of homologous budABC genes, the 2,3-BD-synthesis genes involved in the conversion of pyruvate to 2,3-BD. This is the first report presenting a high 2,3-BD production by R.ornithinolytica which has attracted little attention with respect to 2,3-BD production, extending the microbial spectrum of 2,3-BD producers. PMID:27760200

  20. Mining lakes in Germany; Tagebauseen in Deutschland. Gegenwaertiger Kenntnisstand ueber wasserwirtschaftliche Belange von Braunkohlentagebaurestloechern - ein Ueberblick

    Energy Technology Data Exchange (ETDEWEB)

    Nixdorf, B.; Hemm, M.; Schlundt, A.; Kapfer, M.; Krumbeck, H. [Brandenburgische Technische Univ., Cottbus (Germany). Lehrstuhl Gewaesserschutz]|[UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Magdeburg (Germany)

    2001-06-01

    More than 500 mining lakes of different age and maturity have formed in the lignite mining areas in Germany during the last hundred years. Compared to natural lakes mining lakes have a complex and diverse morphometry. They will be among the largest and deepest lakes in Germany (Hambacher See, Goitsche, Garzweiler II, Geiseltal) and have good chance of avoiding eutrophication. About 100 mining lakes will be greater than 50 ha. 230 lakes are documented in this report concerning morphometry, flooding and mixis regime, hydrochemistry, limnology, colonization, use and development of water quality. They are among the largest (Hambacher See, Goitsche, Garzweiler II, Geiseltal) and most acidic lakes in Germany. The extremely high acidity is from both iron and hydrogen ions due to pyrit oxidation. It influences trophic situation and food webs in mining lakes and reduces a diverse use of these lakes. (orig.) [German] Die Seelandschaft Deutschlands wird durch den Braunkohlenbergbau um ueber 500 Seen reicher. Technologiebedingt herrscht dabei eine grosse morphologische Vielfalt innerhalb der Tagebauseen vor, welche die groessten und tiefsten Seen Deutschlands hervorbringen wird (Hambacher See, Goitsche, Garzweiler II, Geiseltal), aber auch zahlreiche kleine, meist flachere Gewaesser miteinschliesst. Etwa 100 Taugebauseen sind groesser als 50 ha. Kleinere Tagebauseen wie z.B. die der Ville in Nordrhein-Westfalen wurden ebenfalls ausfuehrlich dokumentiert. In dieser Dokumentation wurden ueber 490 Seen erfasst, 230 davon wurden in der Dokumentation nach folgenden Kriterien beschrieben: Entstehung, Flutungsregime, Morphometrie und Mixis, Chemismus und Gewaesserentwicklung, Besiedlung und Nutzung. Dem Problem der Versauerung durch die Verwitterung sulfidischer Mineralien (Pyrit, Markasit) wurde besondere Aufmerksamkeit gewidmet, weil sich biologische Komponenten und Gewaesserzustaende (Trophie, Nahrungsketten) abweichend zu den normalen Hartwasserseen Deutschlands verhalten und

  1. Große statistische Unsicherheit beim Anteil der Top-Vermögenden in Deutschland

    OpenAIRE

    Westermeier, Christian; Grabka, Markus M.

    2015-01-01

    Analysen zur Vermögensungleichheit auf Basis von Bevölkerungserhebungen untererfassen tendenziell die Top-Vermögenden. Gerade dieser Personenkreis ist aber von besonderer Bedeutung, weil er einen beträchtlichen Teil des Gesamtvermögens besitzt. Offizielle Registerdaten zur Vermögenssituation liegen für Deutschland nicht vor, die Top-Vermögen lassen sich lediglich an Hand von "Reichen-Listen" simulieren. Kombiniert man etwa die Forbes-Liste, die rund 50 Dollar-Milliardäre mit deutscher Staatsb...

  2. Bibliothekarische Berufsethik in der Praxis – Ergebnisse eines Studienprojekts aus Deutschland und Großbritannien

    Directory of Open Access Journals (Sweden)

    Jens Boye

    2011-10-01

    Full Text Available Sowohl in Deutschland als auch in Großbritannien existieren seit einigen Jahren Grundsatzpapiere zur Berufsethik im Informations- und Bibliotheksbereich. Neben der bloßen Existenz derartiger Kodizes stellt sich die Frage, welche Relevanz diese Dokumente in der beruflichen Praxis haben. Dieser Frage wurde im Rahmen einer Team-Projektarbeit an der FH Köln nachgegangen. Mithilfe eines standardisierten Fragebogens wurden deutsche Bibliotheksleitungen zu der Thematik befragt. In Großbritannien wurde ein Interview mit Paul Sturges geführt, darüber hinaus erfolgte eine Analyse der Online-Angebote von CILIP, insbesondere des Information Ethics Blog.

  3. Konjunktur bleibt robust. Prognose-Update: Die konjunkturelle Lage in Deutschland zur Jahreswende 2016/2017

    OpenAIRE

    Gustav A. Horn; Herzog-Stein, Alexander; Hohlfeld, Peter; Rietzler, Katja; Theobald, Thomas; Tober, Silke

    2016-01-01

    Die Weltkonjunktur ist im Prognosezeitraum nur verhalten aufwärtsgerichtet. Zwar gewinnt die konjunkturelle Dynamik in den USA wieder etwas an Fahrt und auch die Erholung im Euroraum setzt sich - wenngleich etwas abgeschwächt - fort. Zugleich sind jedoch die Aussichten für die Weltkonjunktur aufgrund der Probleme in vielen Schwellenländern, die sich infolge der Leitzinserhöhung in den USA verschärfen könnten, etwas gedämpft.In Deutschland setzt sich der moderate Konjunkturaufschwung im Jahr 2...

  4. GHB, GBL and 1,4-BD addiction.

    Science.gov (United States)

    Brunt, Tibor M; van Amsterdam, Jan G C; van den Brink, Wim

    2014-01-01

    A growing body of evidence shows that gamma-hydroxybutyric acid (GHB) is an addictive substance. Its precursors gammabutyrolactone (GBL) and 1,4-butanediol (1,4-BD) show the same properties and may pose even more risks due to different pharmacokinetics. There are indications that problematic GHB use is increasing in the European Union. This review investigates the existing literature on the neurochemistry of GHB and its precursors, their acute toxicity, addiction potential and withdrawal, the proposed molecular mechanism underlying addiction and the treatment of withdrawal and addiction. Current evidence shows that GHB and its precursors are highly addictive, both in humans and animals, probably through a GABAB receptor related mechanism. Severity of withdrawal symptoms can be considered as a medical emergency. Recent studies suggest that benzodiazepines are not very effective, showing a high treatment resistance, whereas detoxification with pharmaceutical GHB proved to be successful. However, relapse in GHB use is frequent and more research is warranted on relapse prevention. This might aid medical practitioners in the field and improve general understanding of the severity of addiction to GHB, GBL and 1,4-BD.

  5. La base de datos BD.EURS (NACE Rev.1

    Directory of Open Access Journals (Sweden)

    Javier Escriba

    2014-01-01

    Full Text Available El objetivo de este documento es el de presentar la base de datos de regiones europeas desagregadas sectorialmente BD.EURS. Esta base es el resultado de analizar la calidad y la congruencia de las diferentes fuentes estadísticas disponibles sobre las variables macroeconómicas básicas —VAB en nominales y reales, empleo, formación bruta de capital fijo y stock de capital— para los países y a nivel NUTS-2. En esta primera versión de la BD.EURS nos hemos limitado a 121 regiones de nueve países europeos, aquellas regiones en las que se dispone de mayor calidad y cantidad de información para el periodo 1995-2007. Éstas son: las regiones de Bélgica, Alemania, Francia, Italia, Holanda, Austria, Portugal, Suecia y España. La fuente básica de información son las series regionales de EUROSTAT y utilizando también como referencia la información existente para países especialmente en las bases AMECO y EU-KLEMS.

  6. Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling.

    Directory of Open Access Journals (Sweden)

    Michael J Capeness

    Full Text Available Bdellovibrio bacteriovorus are facultatively predatory bacteria that grow within gram-negative prey, using pili to invade their periplasmic niche. They also grow prey-independently on organic nutrients after undergoing a reversible switch. The nature of the growth switching mechanism has been elusive, but several independent reports suggested mutations in the hit (host-interaction locus on the Bdellovibrio genome were associated with the transition to prey-independent growth. Pili are essential for prey entry by Bdellovibrio and sequence analysis of the hit locus predicted that it was part of a cluster of Type IVb pilus-associated genes, containing bd0108 and bd0109. In this study we have deleted the whole bd0108 gene, which is unique to Bdellovibrio, and compared its phenotype to strains containing spontaneous mutations in bd0108 and the common natural 42 bp deletion variant of bd0108. We find that deletion of the whole bd0108 gene greatly reduced the extrusion of pili, whereas the 42 bp deletion caused greater pilus extrusion than wild-type. The pili isolated from these strains were comprised of the Type IVa pilin protein; PilA. Attempts to similarly delete gene bd0109, which like bd0108 encodes a periplasmic/secreted protein, were not successful, suggesting that it is likely to be essential for Bdellovibrio viability in any growth mode. Bd0109 has a sugar binding YD- repeat motif and an N-terminus with a putative pilin-like fold and was found to interact directly with Bd0108. These results lead us to propose that the Bd0109/Bd0108 interaction regulates pilus production in Bdellovibrio (possibly by interaction with the pilus fibre at the cell wall, and that the presence (and possibly retraction state of the pilus feeds back to alter the growth state of the Bdellovibrio cell. We further identify a novel small RNA encoded by the hit locus, the transcription of which is altered in different bd0108 mutation backgrounds.

  7. 76 FR 64791 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG (RRD) BR700-710 Series Turbofan...

    Science.gov (United States)

    2011-10-19

    ... and the Low Pressure (LP) compressor blades as specified in the Rolls-Royce Deutschland Alert NMSB... between the national government and the States, or on the distribution of power and responsibilities among... each individual critical part except the fan shaft and LP turbine rotor shaft has experienced...

  8. 75 FR 48617 - Airworthiness Directives; Eurocopter Deutschland GmbH (ECD) Model MBB-BK 117 C-2 Helicopters

    Science.gov (United States)

    2010-08-11

    ... vibration, and subsequent loss of control of the helicopter. Actions and Compliance (e) Before further... Deutschland GmbH (ECD) Model MBB-BK 117 C-2 Helicopters AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) for ECD Model MBB-BK 117 C-2 helicopters. This proposed AD results from a...

  9. 75 FR 51651 - Airworthiness Directives; Rolls-Royce Deutschland Ltd. & Co. KG. (RRD) Models Tay 650-15 and Tay...

    Science.gov (United States)

    2010-08-23

    ...-12] RIN 2120-AA64 Airworthiness Directives; Rolls-Royce Deutschland Ltd. & Co. KG. (RRD) Models Tay 650-15 and Tay 651-54 Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... realized that the same unsafe condition could potentially occur on more serial numbers for the Tay 650-15...

  10. Too high expectations. Air pollution abatement: Will Germany achieve its goal?; Zuviel versprochen. Klimaschutz: Erreicht Deutschland das Ziel?

    Energy Technology Data Exchange (ETDEWEB)

    Quaschning, V. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR), Aussenstelle Plataforma Solar, Almeria (Spain). Abt. Systemanalyse

    2003-04-01

    Germany is the world-wide leader in air pollution abatement, but its ambitious goals will not be met if it does not make bigger efforts. (orig.) [German] Deutschland gilt als Vorreiter im internationalen Klimaschutz und hat sich selbst hohe Ziele gesteckt. Es droht jedoch, an den eigenen Anspruechen zu scheitern, wenn keine groesseren Anstrengungen zum Klimaschutz getroffen werden. (orig.)

  11. DevelopmentofagraphicaluserinterfaceforBD/GPSsimulatorbasedonmatlabprogram%基于MATLAB的BD/GPS模拟器界面显控软件设

    Institute of Scientific and Technical Information of China (English)

    李银虎; 王帅; 古泉颖

    2013-01-01

    MATLAB具有方便的硬件接口函数,可以作为PC上位机的显控软件平台。利用图形用户界面设计向导GUIDE设计了显示控制界面程序,通过串口与BD/GPS卫星信号模拟器主机进行通信,实现卫星信息的显示,并下发控制命令,介绍了详细的步骤和架构。%Matlab is powerful software for large engineering calculations and scientific simulation. It’s necessary and convenient to develop a Graphical User Interface (GUI) if one’s program has too many input parameters. In this paper a Graphical User Interface is designed for a BD/GPS satellite signal simulator through serial interface. It can be used for inputting parameters, and for satellite information display and control.

  12. The lifestyle switch protein Bd0108 of Bdellovibrio bacteriovorus is an intrinsically disordered protein.

    Directory of Open Access Journals (Sweden)

    Gerd Prehna

    Full Text Available Bdellovibrio bacteriovorus is a δ-proteobacterium that preys upon Salmonella spp., E. coli, and other Gram-negative bacteria. Bdellovibrio can grow axenically (host-independent, HI, rare and mutation-driven or subsist via a predatory lifecycle (host-dependent, HD, the usual case. Upon contact with prey, B. bacteriovorus enters the host periplasm from where it slowly drains the host cytosol of nutrients for its own replication. At the core of this mechanism is a retractile pilus, whose architecture is regulated by the protein Bd0108 and its interaction with the neighboring gene product Bd0109. Deletion of bd0108 results in negligible pilus formation, whereas an internal deletion (the one that instigates host-independence causes mis-regulation of pilus length. These mutations, along with a suite of naturally occurring bd0108 mutant strains, act to control the entry to HI growth. To further study the molecular mechanism of predatory regulation, we focused on the apparent lifecycle switch protein Bd0108. Here we characterize the solution structure and dynamics of Bd0108 using nuclear magnetic resonance (NMR spectroscopy complemented with additional biophysical methods. We then explore the interaction between Bd0108 and Bd0109 in detail utilizing isothermal titration calorimetry (ITC and NMR spectroscopy. Together our results demonstrate that Bd0108 is an intrinsically disordered protein (IDP and that the interaction with Bd0109 is of low affinity. Furthermore, we observe that Bd0108 retains an IDP nature while binding Bd0109. From our data we conclude that Bdellovibrio bacteriovorus utilizes an intrinsically disordered protein to regulate its pilus and control predation signaling.

  13. Die „California Digital Open Source Library“: Entstehung, Herausforderungen, Vorbild für Deutschland?

    Directory of Open Access Journals (Sweden)

    Sibylle Hermann

    2015-07-01

    Full Text Available Um den Zugang zu Bildung zu erleichtern, gibt es seit einigen Jahren Bestrebungen, Lehrinhalte kostenlos zur Verfügung zu stellen. Die UNESCO führte den Begriff „Open Educational Resources“ ein, um diese Inhalte zu bezeichnen. Die Notwendigkeit, freie Bildungsressourcen für jedermann bereitzustellen, wird vor allem in den USA, aber inzwischen auch in Deutschland diskutiert. Da Lehrbücher in den USA sehr teuer sind und viele Studenten diese nicht mehr erwerben können, ist es dort seit einigen Jahren das Ziel, nicht nur Vorlesungen, sondern auch Lehrbücher online frei zur Verfügung zu stellen. Um diese Open Textbooks auffindbar zu machen, wurden Plattformen wie die „California Digital Open Source Library“ aufgebaut. Dieser Aufsatz stellt deren Entwicklung dar und diskutiert Probleme, die bei ihrer Einführung auftraten, sowie die Bedeutung der Verwendung von Open Textbooks in Deutschland. Abschließend wird beleuchtet, welche Rolle die Bibliotheken bei Etablierung von freien Lehrinhalten einnehmen können.

  14. Aufwind und Gegenwind. Erfahrungen mit und aus einem Frauenstudiengang in Deutschland

    Directory of Open Access Journals (Sweden)

    Anina Mischau

    2004-11-01

    Full Text Available Derzeit gibt es (an Fachhochschulen in Deutschland (noch vier (teil-monoedukative Studienangebote für Frauen. Der erste „Frauenstudiengang“ startete zum Wintersemester 1997/98 in Wilhelmshaven, der „jüngste“ im Sommersemester 2002 in Furtwangen. Diese „Frauenstudiengänge“ treffen bis heute in Politik, Wissenschaft und Wirtschaft nicht nur auf Befürworter/-innen, sondern noch immer auf große Skepsis, auf Vorurteile sowie auf erklärte Gegner/-innen. Beide Gruppen verfolgen die Entwicklung dieser bildungs- wie geschlechterpolitischen Reformmaßnahmen mit „Argusaugen“, um ihre Argumente für das „Für und Wider“ einer Geschlechtertrennung, ihre Prognosen über deren „Erfolg“ oder „Misserfolg“ durch praktische Erfahrungen „bestätigt“ zu sehen. Mit dem Buch von Gudrun-Axeli Knapp und Carmen Gransee liegt nun die erste abgeschlossene Begleitforschung zum „ältesten“ Frauenstudiengang in Deutschland vor. Auch der Sammelband von Carmen Gransee bezieht sich auf Erfahrungen aus Wilhelmshaven und bettet diese in einen umfassenderen Diskurs ein. Beiden Büchern kommt daher für eine kritische Reflexion und mögliche Neuorientierung, aber auch für die Frage nach den Chancen einer nachhaltigen Institutionalisierung und Ausweitung von Frauenstudiengängen an deutschen Hochschulen eine „exponierte“ Bedeutung zu.

  15. BD380: The Wild Card for Semi-automatic Rotor Spinning Mills%BD380——半自动转杯纺纱厂的王牌

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ 苏拉(捷克)公司以BD 380型半自动转杯纺纱机给了市场一个惊喜.BD 380型转杯纺纱机纺杯转速最高达11万r/min,引纱速度最快达180m/min,纺纱器最多达352个.BD 380标志着高质、高产和高产品适应性.

  16. BD380半自动转杯纺纱机%BD380 the wild card for semi-automatic rotor spinning mills

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    苏拉(捷克)公司以BD380型半自动转杯纺纱机给市场一个惊喜。BD380型转杯纺纱机纺杯转速最高达110000r/rain,引纱速度最快达180m/min,纺纱器最多达352个。BD380标志着高质量、高产量和高产品适应性(图1)。

  17. Detection of radiation pressure acting on 2009 BD

    Science.gov (United States)

    Micheli, Marco; Tholen, David J.; Elliott, Garrett T.

    2012-05-01

    We report the direct detection of radiation pressure on the asteroid 2009 BD, one of the smallest multi-opposition near-Earth objects currently known, with H ˜ 28.4. Under the purely gravitational model of NEODyS the object is currently considered a possible future impactor, with impact solutions starting in 2071. The detection of a radiation-related acceleration allows us to estimate an Area to Mass Ratio ( AMR) for the object, that can be converted (under some assumptions) into a range of possible values for its average density. Our result AMR = (2.97 ± 0.33) × 10 -4 m 2 kg -1 is compatible with the object being of natural origin, and it is narrow enough to exclude a man-made nature. The possible origin of this object, its future observability, and the importance of radiation pressure in the impact monitoring process are also discussed.

  18. A Dynamical Investigation of the Proposed BD +20 2457 System

    CERN Document Server

    Horner, Jonathan; Hinse, Tobias C; Marshall, Jonathan P

    2014-01-01

    We present a detailed dynamical analysis of the orbital stability of the BD +20 2457 system, which features planets or brown dwarfs moving on relatively eccentric orbits. We find that the system exhibits strong dynamical instability on astronomically short timescales across a wide range of plausible orbital eccentricities, semi-major axes, and inclinations. If the system truly hosts massive planets or brown dwarfs, our results suggest that they must move on orbits significantly different to those proposed in the discovery work. If that is indeed the case, then it is likely that the best-fit orbital solutions for the proposed companions will change markedly as future observations are made. Such observations may result in the solution shifting to a more dynamically-stable regime, potentially one where stability is ensured by mutually resonant motion.

  19. Detection of radiation pressure acting on 2009 BD

    CERN Document Server

    Micheli, Marco; Elliott, Garrett T

    2011-01-01

    We report the direct detection of radiation pressure on the asteroid 2009 BD, one of the smallest multi-opposition near-Earth objects currently known, with H ~ 28.4. Under the purely gravitational model of NEODyS the object is currently considered a possible future impactor, with impact solutions starting in 2071. The detection of a radiation-related acceleration allows us to estimate an Area to Mass Ratio (AMR) for the object, that can be converted (under some assumptions) into a range of possible values for its average density. Our result AMR = (2.97 \\pm 0.33) x 10^(-4) m^2 kg^(-1) is compatible with the object being of natural origin, and it is narrow enough to exclude a man-made nature. The possible origin of this object, its future observability, and the importance of radiation pressure in the impact monitoring process, are also discussed.

  20. ISO spectroscopy of young intermediate-mass stars in the BD+40 degrees 4124 group

    NARCIS (Netherlands)

    van den Ancker, ME; Wesselius, PR; Tielens, AGGM

    2000-01-01

    We present the results of ISO SWS and LWS grating scans towards the three brightest members of the BD+40 degrees 4124 group in the infrared: BD+40 degrees 4124 (B2Ve), LkH alpha 224 (A7e) and the embedded source LkH alpha 225. Emission from the pure rotational lines of H(2). from re-vibrational tran

  1. The analysis of B-d ->(eta, eta ')l(+)l(-) decays in the standard model

    NARCIS (Netherlands)

    Erkol, G; Turan, G

    2003-01-01

    We study the differential branching ratio, the branching ratio and the CP-violating asymmetry for the exclusive B-d --> (eta,eta')l(+)l(-) decays in the standard model. We deduce the B-d --> (eta,eta') form factors from the form factors of B --> pi available in the literature, by using the SU(3)(F)

  2. RVX-297- a novel BD2 selective inhibitor of BET bromodomains

    Energy Technology Data Exchange (ETDEWEB)

    Kharenko, Olesya A., E-mail: olesya@zenithepigenetics.com [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); Gesner, Emily M.; Patel, Reena G.; Norek, Karen [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada); White, Andre; Fontano, Eric; Suto, Robert K. [Xtal BioStructures, Inc., 12 Michigan Dr., Natick, MA 01760 (United States); Young, Peter R.; McLure, Kevin G.; Hansen, Henrik C. [Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1 (Canada)

    2016-08-12

    Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET inhibitor RVX-297 that is structurally related to the clinical compound RVX-208, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. We report that RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. We demonstrate the differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography, and describe the structural differences driving the BD2 selective binding of RVX-297. The isothermal titration calorimetry (ITC) data illustrate the related differential thermodynamics of binding of RVX-297 to single as well as dual BET bromodomains. - Highlights: • A novel inhibitor of BET bromodomains, RVX-297 is described. • The differential binding modes of RVX-297 in BD1 and BD2 domains of BRD4 and BRD2 using X-ray crystallography are described. • RVX-297 preferentially binds to the BD2 domains of the BET bromodomains. • The structural and thermodynamic properties of the BD2 selective binding of RVX-297 are characterized.

  3. Nuclear hBD-1 accumulation in malignant salivary gland tumours.

    NARCIS (Netherlands)

    Wenghoefer, M.H.; Pantelis, A.; Dommisch, H.; Gotz, W.; Reich, R.; Berge, S.; Martini, M.; Allam, J.P.; Jepsen, S.; Merkelbach-Bruse, S.; Fischer, H.P.; Novak, N.; Winter, J.

    2008-01-01

    BACKGROUND: Whereas the antimicrobial peptides hBD-2 and -3 are related to inflammation, the constitutively expressed hBD-1 might function as 8p tumour suppressor gene and thus play a key role in control of transcription and induction of apoptosis in malignant epithelial tumours. Therefore this

  4. Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

    Directory of Open Access Journals (Sweden)

    Girolamo Jose Barrera

    2013-09-01

    Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p < 0.01.Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent

  5. Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

    Directory of Open Access Journals (Sweden)

    Girolamo Jose Barrera

    2013-09-01

    Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent caries

  6. ZWEI 'JAHRHUNDERTHOCHWASSER' IN ELF JAHREN - EIN VERGLEICH DER HOCHWASSEREREIGNISSE VON 2002 UND 2013 (IN DEUTSCHLAND

    Directory of Open Access Journals (Sweden)

    ANJA KLEINEBRAHN

    2014-05-01

    Full Text Available Zwei 'jahrhunderthochwasser' in elf jahren - ein vergleich der hochwasserereignisse von 2002 und 2013 (in Deutschland. Worldwide floods are among the most frequent and most momentous natural disasters. They occur in unpredictable intervals and dimensions and always bring particularly devastating or catastrophic impacts, if they get into contact with people or its uses. Within eleven years only Germany was affected of two so-called 'century-floods'. The expiry of extreme high water can be influenced by technical measures only up to a certain degree. It is therefore necessary to have a high protection from the effects of floods and to keep the impact as low as possible. Both being prepared as well as possible and being capable of acting for the case of emergency are corequisite. Flood protection is a longsome and s steadily continuing process. In dealing with the consequences of floods both political measures and the commitment and solidarity of the citizens were in demand.

  7. Geothermal sites and systems in Germany; Verzeichnis geothermischer Standorte: Geothermische Anlagen in Deutschland auf einen Blick

    Energy Technology Data Exchange (ETDEWEB)

    Pester, S.; Schellschmidt, R.; Schulz, R.

    2007-07-15

    In 2004, The BLA-GEO (Bund-Laender-Ausschuss Bodenforschung) commissioned the SGD (Staatliche Geologische Dienste) to set up two working groups ''Utilisation of the Near-Surface Geothermal Potential'' and ''Utilisation of the Deep Geothermal Potential''. The two working groups are to develop a national digital product catalogue for economically efficient utilisation of geothermal data. The working group ''Deep Geothermal Potential'' published a manual which outlines methods, the data base and projecting steps for deep geothermal projects: http://www.geotis.de/homepage/Informationen/Arbeitshilfe 08022007.pdf, which is supplemented by a detailed table of deep geothermal projects in Germany, whether in the operating, construction or projecting phase. The data are published on the web as part of the Geothermisches Informationssystem fuer Deutschland (Schulz et al.). (orig.)

  8. Quarterly report on the electric power industry in the Federal Republic of Germany. 1st quarter 2000. Power generation in public-owned electric utilities, the industrial independent units and the Federal Railways and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 1. Vierteljahr 2000. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    2000-12-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  9. Quarterly report on the electric power industry in the Federal Republic of Germany. 1st quarter 1997. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 1. Vierteljahr 1997. Stromerzeugung der oeffentlichen Eletrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG, sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  10. Quarterly report on the electric power industry in the Federal Republic of Germany. 4. quarter 2000. Power generation in public-owned electric utilities, the industrial independent units and the Federal Railways and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 4. Vierteljahr 2000. Stromerzeugung der allgemeinen Elektrizitaetswerke einschliesslich der Deutschen Bahn AG und der industriellen Eigenanlagen sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Karasch, G.M.

    2002-01-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the Deutsche Bahn AG. The data have been derived from the monthly reports of the Federal Office of Statistics. [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen.

  11. Annual report of the electric power industry of the Federal Republic of Germany 2000. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 2000. Stromerzeugung der allgemeinen Elektrizitaetswerke einschliesslich der Deutschen Bahn AG und der industriellen Eigenanlagen sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Karasch, G.M.

    2002-05-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. [German] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauchs aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern.

  12. Quarterly report on the electric power industry in the Federal Republic of Germany. 3rd quarter 1996. Power generation in publicly-owned electric utilities, the industrial independent units and the Federal Railways, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 3. Vierteljahr 1996. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (HS) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (HS)

  13. Quarterly report on the electric power industry in the Federal Republic of Germany. 2nd quarter 1997. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 2. Vierteljahr 1997. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  14. Annual report of the electric power industry of the Federal Republic of Germany 1995. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 1995. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. (HS) [Deutsch] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauches aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern. (HS)

  15. Quarterly report on the electric power industry in the Federal Republic of Germany. 3. quarter 2000. Power generation in public-owned electric utilities, the industrial independent units and the Federal Railways and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 3. Vierteljahr 2000. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    2001-04-01

    The report provides data on public electricity supply, on power generation plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (HS) [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (HS)

  16. Quarterly report on the electric power industry of the Federal Republic of Germany. 4th quarter 1997. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 4. Quartal 1997. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  17. Quarterly report on the electric power industry in the Federal Republic of Germany. 4th quarter 1996. Power generation in publicly-owned electric utilities, the industrial independent units and the Federal Railways, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 4. Vierteljahr 1996. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  18. Quarterly report on the electric power industry in the Federal Republic of Germany. 3rd quarter 1997. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 3. Vierteljahr 1997. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  19. Quarterly report on the electric power industry in the Federal Republic of Germany. 2nd quarter 1999. Power generation in publicly-owend electric utilities, the industrial independent units and the Federal Railways, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 2. Vierteljahr 1999. Stromerzeugung der oeffentlich Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1999-11-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  20. Quarterly report on the electric power industry in the Federal Republic of Germany. 2nd quarter 2000. Power generation in public-owned electric utilities, the industrial independent units, and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 2. Vierteljahr 2000. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    2001-01-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (HS) [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitendes Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (HS)

  1. Annual report of the electric power industry of the Federal Republic of Germany 1998. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 1998. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1999-12-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. (orig.) [German] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauchs aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern. (orig.)

  2. Annual report of the electric power industry of the Federal Republic of Germany 1997. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 1997. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1999-01-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. (orig.) [Deutsch] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauchs aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern. (orig.)

  3. Quarterly report on the electric power industry in the Federal Republic of Germany. 3rd quarter 1999. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 3. Vierteljahr 1999. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    2000-02-01

    The report provides data on public electricity supply, on power generation plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (HS) [German] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (HS)

  4. Annual report of the electric power industry of the Federal Republic of Germany 1996. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 1996. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. (orig.) [Deutsch] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauchs aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern. (orig.)

  5. Annual report of the electric power industry of the Federal Republic of Germany 1999. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Jahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland 1999. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    2000-08-01

    For the year under report, figures are given on: Origin and consumption of electric power; power generation in public utilities, industrial plants and the Deutsche Bahn AG; development of power consumption in the network of public utilities in the federal states; net power generation and consumption in industry and development of the gross power generation in public power plants and industrial units in the federal states. (orig.) [German] Fuer das Berichtsjahr werden in Tabellen Zahlen dargestellt betreffend: Herkunft und Verbleib der elektrischen Arbeit; Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG; Entwicklung des Stromverbrauchs aus dem Netz der oeffentlichen Elektrizitaetsversorgung in den Bundeslaendern; Netto-Stromerzeugung und -Stromverbrauch der Industrie und Entwicklung der Brutto-Stromerzeugung der oeffentlichen Kraftwerke und der industriellen Eigenanlagen in den Bundeslaendern. (orig.)

  6. Quarterly report on the electric power industry in the Federal Republic of Germany. 3rd quarter 1998. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 3. Vierteljahr 1998. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1999-02-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  7. Quarterly report on the electric power industry in the Federal Republic of Germany. 4th quarter 1998. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, an overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 4. Vierteljahr 1998. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1999-07-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  8. Quarterly report on the electric power industry in the Federal Republic of Germany. 2nd quarter 1998. Power generation in publicly-owned electric utilities, the industrial independent units and the Deutsche Bahn AG, and overall power consumption in the Federal Republic of Germany; Vierteljahresbericht ueber die Elektrizitaetswirtschaft in der Bundesrepublik Deutschland. 2. Vierteljahr 1998. Stromerzeugung der oeffentlichen Elektrizitaetswerke, der industriellen Eigenanlagen und der Deutschen Bahn AG sowie Gesamtstromverbrauch in der Bundesrepublik

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, L.

    1998-10-01

    The report provides data on public electricity supply, on power generation in plants of the mining industry and the manufacturing industry, and on the German Federal Railways. The data have been derived from the monthly reports of the Federal Office of Statistics. (orig.) [Deutsch] Der Bericht enthaelt Zahlen fuer die oeffentliche Versorgung, fuer die Eigenanlagen im Bergbau und Verarbeitenden Gewerbe und fuer die Deutsche Bundesbahn. Die Zahlen sind den monatlichen Berichten des Statistischen Bundesamtes entnommen. (orig.)

  9. Engagement für Flüchtlinge. Die Aufnahme vietnamesischer »Boat People« in der Bundesrepublik

    Directory of Open Access Journals (Sweden)

    Frank Bösch

    2017-03-01

    Full Text Available In the late 1970s, the Federal Republic of Germany witnessed a period of committed public outreach for Vietnamese refugees. While West Germany had not accepted significant numbers of non-European refugees before then, now tens of thousands of ›Boat People‹ rescued from the sea or flown out of camps found shelter as ›quota refugees‹. This article analyses the role civil society groups and political parties, media, and bureaucracy played in this. It shows that it was initially increasing public and international pressure that persuaded the social-liberal administration to accept refugees from Indochina, and that the concurrence of civic and state action subsequently reinforced the decision. Public pressure was created in large part by media campaigns and initiatives by Christian Democrats, who took a decisive stand in favour of taking in the refugees. A critical factor here was that the ›Boat People‹ were connected discursively with German post-war history. The article shows how refugee admission methods and new forms of humanitarian aid developed, both of which can be interpreted as civic and bureaucratic change. Rising xenophobia in the early 1980s eventually curbed this support. * * * In der Bundesrepublik entfaltete sich Ende der 1970er-Jahre eine engagierte Hilfe für Flüchtlinge aus Vietnam. Während Westdeutschland bis dahin kaum außereuropäische Flüchtlinge aufgenommen hatte, fanden nun mehrere zehntausend »Boat People« Schutz als »Kontingentflüchtlinge«, die im Meer gerettet und aus Lagern eingeflogen wurden. Der Aufsatz analysiert, welche Rolle dabei zivilgesellschaftliche Gruppen, politische Parteien, Medien und Bürokratie spielten. Anfangs bewegte vor allem öffentlicher und internationaler Druck die sozialliberale Regierung zur Aufnahme der Indochina-Flüchtlinge; später ergänzten sich zivilgesellschaftliches und staatliches Handeln aber wechselseitig. Der öffentliche Druck entstand insbesondere durch mediale

  10. Die Umsetzung der VN-Agenda 2030 für nachhaltige Entwicklung: welche Signale Deutschland jetzt international setzen sollte

    OpenAIRE

    Beisheim, Marianne

    2016-01-01

    Beim Nachhaltigkeitsgipfel der Vereinten Nationen (VN) im September 2015 haben die Staats- und Regierungschefs und -chefinnen aller Mitgliedstaaten die 2030-Agenda für nachhaltige Entwicklung verabschiedet. Auch die Bundesregierung hat zugesichert, die Umsetzung rasch angehen zu wollen, sowohl in Deutschland als auch weltweit mit Partnern und deutscher Unterstützung. Kanzlerin Merkel kündigte an, ehrgeizige Umsetzungsanstrengungen bereits im Juli in New York vorstellen zu wollen. Welche Impul...

  11. Basisindikatoren der ökonomischen Entwicklung in Deutschland, Großbritannien, Schweden, USA - 1950 bis 2000

    OpenAIRE

    Thome, Helmut; Birkel, Christoph

    2005-01-01

    Die Vergleichsstudie präsentiert Daten zur ökonomischen Entwicklung in Deutschland, England, Schweden und den USA im Zeitraum 1950-2000. Dabei gliedern sich die Ausführungen in folgende ökonomische Kenngrößen: (1) Wachstum und Niveau des Volkseinkommens, (2) Produktivitätsentwicklung, (3) Arbeitslosigkeit, (4) Beschäftigungsstrukturen (Arbeitszeitvolumen und Beschäftigungsquoten, sektorale Entwicklung, öffentlicher und privater Sektor, Frauenerwerbsquote, Selbständigenquote) (5) Entwicklung d...

  12. 75 FR 67611 - Airworthiness Directives; Rolls-Royce Deutschland Ltd. & Co. KG. (RRD) Models Tay 650-15 and Tay...

    Science.gov (United States)

    2010-11-03

    ... Deutschland Ltd. & Co. KG. (RRD) Models Tay 650-15 and Tay 651-54 Turbofan Engines AGENCY: Federal Aviation... numbers for the Tay 650-15 engines and on the Tay 651-54 engines. This AD, superseding EASA AD 2008-0122... numbers for the Tay 650-15 engines and in adding the Tay 651-54 engines. We are issuing this AD to...

  13. Territoriale Beschäftigungspakte im Institutionengefüge nationaler Arbeitsmarktpolitik in Österreich, den Niederlanden und Deutschland

    OpenAIRE

    Buchegger-Traxler, Anita; Roggenkamp, Martin; Scheffelt, Elke

    2003-01-01

    "Das vorliegende Papier untersucht, inwieweit sich die durch die Europäische Kommission in den Jahren 1998-2001 geförderten "Territorialen Beschäftigungspakte" vor dem Hintergrund der jeweiligen Arbeitsmarkt- und Beschäftigungsentwicklungen in das Akteurs- und Institutionengefüge in Österreich, den Niederlanden und Deutschland einfügen. In Österreich wurden die Pakte angesichts einer relativ entspannten Arbeitsmarktsituation im Kontext einer Dezentralisierung der Arbeitsmarktpolitik flächende...

  14. Potentiale für den Einsatz von Nährstoff-Filtersystemen in Deutschland zur Verringerung der Nährstoffeinträge in Oberflächengewässer

    DEFF Research Database (Denmark)

    Holsten, Bettina; Bednarek, Agnieszka; Fier, Annegret

    2012-01-01

    Der Einsatz von Filtern zur Reduzierung von Stickstoff- und Phosphoreinträgen aus der Landwirtschaft in die Oberflächengewässer wurde in Deutschland bisher kaum untersucht. In einem Workshop wurde der Stand der Untersuchungen von Projekten in Polen, Dänemark, Deutschland und Frankreich vorgestell...

  15. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 3: toxicological and ecotoxicological substance profiles of selected flame retardants; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 3: Toxikologisch-oekotoxikologische Stoffprofile ausgewaehlter Flammschutzmittel

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Kruse, H.; Paulsen, O.; Schau, C.; Wieben, M.; Boehde, U.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  16. The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance.

    Directory of Open Access Journals (Sweden)

    Julia Leclerc

    Full Text Available Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance.

  17. Brownian dynamics simulations on CPU and GPU with BD_BOX.

    Science.gov (United States)

    Długosz, Maciej; Zieliński, Paweł; Trylska, Joanna

    2011-09-01

    There has been growing interest in simulating biological processes under in vivo conditions due to recent advances in experimental techniques dedicated to study single particle behavior in crowded environments. We have developed a software package, BD_BOX, for multiscale Brownian dynamics simulations. BD_BOX can simulate either single molecules or multicomponent systems of diverse, interacting molecular species using flexible, coarse-grained bead models. BD_BOX is written in C and employs modern computer architectures and technologies; these include MPI for distributed-memory architectures, OpenMP for shared-memory platforms, NVIDIA CUDA framework for GPGPU, and SSE vectorization for CPU. Copyright © 2011 Wiley Periodicals, Inc.

  18. Component validation of direct diode 488nm lasers in BD Accuri C6 flow cytometers

    Science.gov (United States)

    Chen, Wei P.; Luo, Ningyi D.

    2016-03-01

    The 488nm laser is the most important excitation light source of flow cytometry. The indirect diode (frequency-doubled diode) 488nm lasers are used in the excitation of Becton Dickinson (BD) AccuriTM C6. For using cost effective lasers, we have validated direct diode 488nm lasers as the replacement component of frequency-doubled diode laser. BD Bioscience issued the protocols to cover wavelength, power, noise, and polarization at the operation temperature range of cytometer. Pavilion Integration Corporation (PIC) tested 6 samples as the component validation of direct diode 488nm lasers based on the protocols from BD Biosciences. BD Bioscience also tested one of laser samples to further validate the test results of power, noise, and polarization from PIC.

  19. Effect of flavor-changing neutral currents in the leptonic asymmetry in Bd decays

    Science.gov (United States)

    Branco, G. C.; Parada, P. A.; Morozumi, T.; Rebelo, M. N.

    1993-06-01

    We evaluate the charge asymmetry in equal sign dileptons arising from the decay of a Bd0-Bd0 pair, in the presence of Z-mediated flavor-changing neutral currents. We compare our predictions with those of the standard model and the superweak model. Work supported by the Deprtment of Energy, contract DEAC03-76SF00515 and by a fellowship from OTAN (NATO).

  20. Characterization of Phosphate Transporters BdPT4 and BdPT8 in Mycorrhizal and Non-Mychorrhizal Brachypodium distachyon

    DEFF Research Database (Denmark)

    Clausen, Signe Sandbech

    was generated by Agrobacterium tumefaciens-mediated transformation. The transgenic lines were characterized for effects on growth and plant P uptake, and their subcellular localization was moreover determined by confocal microscopy. Quantitative expression analysis of 11 BdPTs in AM and non-mycorrhizal (NM...

  1. Guillem Fabre, “Pus dels majors” (BdT 216.2; Id., “Hon mais vey, pus truep sordeyor” (BdT 216.1

    Directory of Open Access Journals (Sweden)

    Linda Paterson

    2013-03-01

    Full Text Available The historical circumstances of Guillem Fabre’s two surviving sirventes has given rise to widely divergent views. This essay builds on Parducci’s contextualisation of BdT 216.2 during the War of the Sicilian Vespers and the so-called Aragonese crusade by the French against Pere III of Aragon in 1284-1285. It argues that Guillem is likely to be referring to events say entre nos because Narbonne was the focal point of the gathering French army and preaching of the crusade. All other textual details are compatible with this period and best explained by this context. But while Parducci places the sirventes in May 1285, it must in fact have preceded the death of Martin IV on 29 March, since his speedily-appointed successor Honorius IV could not be blamed for not having preached a crusade against the heathen before the conflict degenerated into further atrocities. Furthermore a slightly earlier timing better explains the allusion to “the best-known man in the world”, the obvious candidate at this time being Charles of Anjou. Guillem probably composed BdT 216.2 during the build-up to war in 1284, before the death of Charles in January 1285, during the period of war preparations and propaganda speeches. It is also argued here that, pace Parducci, BdT 216.1 did not necessarily precede BdT 216.2.

  2. Adipositas: Gesellschaftliche Kosten und Therapiemöglichkeiten. Seit Jahren nimmt Fettleibigkeit in Deutschland zu - mit ernsthaften Folgen für die Betroffenen und die Volkswirtschaft

    OpenAIRE

    Wübker, Ansgar

    2016-01-01

    Der Anstieg von Adipositas (Fettleibigkeit) in Deutschland verursacht hohe gesellschaftliche Kosten und schränkt die Lebensqualität der Betroffenen erheblich ein. Die Gründe für die Erkrankung können überwiegend von den Patienten selbst beeinflusst werden. Ernährung und Bewegung sollten daher in den Fokus rücken, um eine weitere Ausbreitung zu verhindern. Erste Analysen für Deutschland zeigen, dass die radikalste Form der Adipositastherapie, ein chirurgischer Eingriff, Begleiterkrankungen ver...

  3. Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study

    Directory of Open Access Journals (Sweden)

    Moreno-Manzanaro Miriam

    2011-04-01

    Full Text Available Abstract Background Studies in bipolar disorder (BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd (NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales, adherence to treatment (DAI-10 scale and Medication Possession Ratio, quality of life (EQ-5D scale, healthcare resources, and caregiver burden (BAS scale

  4. Medical specialist attendance in nursing homes [Beschreibung und Bewertung der fachärztlichen Versorgung von Pflegeheimbewohnern in Deutschland

    Directory of Open Access Journals (Sweden)

    Balzer, Katrin

    2013-04-01

    Full Text Available [english] The care in nursing homes was examined based on scientific studies. The analysis focuses on dementia and type II diabetes. There is evidence for deficits in the supply of medical specialist attendance to nursing home residents with these diseases in Germany. Compared with corresponding guidelines the medical care for nursing home residents may be too low or inadequate.[german] Es wird die Versorgung in Pflegeheimen auf Basis wissenschaftlicher Studien untersucht. Schwerpunkte der Analyse sind Demenz und Diabetes. Es gibt Hinweise auf fachärztliche Versorgungsmängel bei Pflegeheimbewohnern mit diesen Krankheiten in Deutschland. Verglichen mit entsprechenden Leitlinien bestehen mögliche Unter- bzw. Fehlversorgungen.

  5. Auslandsbanken in Deutschland - Theoretische und empirische Analysen über Markteintritt, Geschäftsentwicklung sowie strategische Positionierungsalternativen

    OpenAIRE

    Knoop, Thomas

    2007-01-01

    Auslandsbanken gewinnen in Deutschland eine immer größere Bedeutung. Obgleich der von der Bundesbank ausgewiesene Marktanteil ausländischer Banken noch immer im Vergleich zu anderen europäischen Ländern unterdurchschnittlich stark ausgeprägt ist, messen ihnen deutsche Bankiers eine hohe Wettbewerbsfähigkeit zu und warnen vor den Folgen einer „Eroberung“ ihrer inländischer Kreditinstitute. Erstmals werden die neu erstarkten Wettbewerber aus den anderen europäischen Nationen sowie den USA im Ra...

  6. Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes.

    Science.gov (United States)

    Kim, MinJeong; Park, Kui Young; Lee, Mi-Kyung; Jin, Taewon; Seo, Seong Jun

    2016-01-01

    Recent studies have revealed that adiponectin can suppress cellular inflammatory signaling pathways. This study aimed to elucidate the effect of adiponectin on the unregulated production of hBD2 in UVB-induced premature senescent keratinocytes. We constructed an in vitro model of premature senescent keratinocytes through repeated exposure to low energy UVB. After repeated low energy UVB exposure, there was significant generation of reactive oxygen species (ROS) and induction of senescence-associated markers, including senescence associated beta-galactosidase activity and expression of p16INK4a and histone H2AX. In addition, the present clinical study showed higher expression of hBD2 in sun-exposed skin of elderly group, and the overexpression of hBD2 was observed by c-Fos activation in vitro. Adiponectin has the ability to scavenge ROS and consequently inhibit MAPKs and SA-markers in UVB-exposed keratinocytes. An inhibitor study demonstrated that adiponectin downregulated hBD2 mRNA expression through suppression of the AP-1 transcription factor components c-Fos via inactivation of p38 MAPK. Collectively, the dysregulated production of hBD2 by the induction of oxidative stress was attenuated by adiponectin through the suppression of p38 and JNK/SAPK MAPK signaling in UVB-mediated premature senescent inducible conditions. These results suggest the feasibility of adiponectin as an anti-photoaging and anti-inflammatory agent in the skin.

  7. BD-Func: a streamlined algorithm for predicting activation and inhibition of pathways

    Directory of Open Access Journals (Sweden)

    Charles D. Warden

    2013-09-01

    Full Text Available BD-Func (BiDirectional FUNCtional enrichment is an algorithm that calculates functional enrichment by comparing lists of pre-defined genes that are known to be activated versus inhibited in a pathway or by a regulatory molecule. This paper shows that BD-Func can correctly predict cell line alternations and patient characteristics with accuracy comparable to popular algorithms, with a significantly faster run-time. BD-Func can compare scores for individual samples across multiple groups as well as provide predictive statistics and receiver operating characteristic (ROC plots to quantify the accuracy of the signature associated with a binary phenotypic variable. BD-Func facilitates collaboration and reproducibility by encouraging users to share novel molecular signatures in the BD-Func discussion group, which is where the novel progesterone receptor and LBH589 signatures from this paper can be found. The novel LBH589 signature presented in this paper also serves as a case study showing how a custom signature using cell line data can accurately predict activity in vivo. This software is available to download at https://sourceforge.net/projects/bdfunc/.

  8. High Milk-Clotting Activity Expressed by the Newly Isolated Paenibacillus spp. Strain BD3526

    Directory of Open Access Journals (Sweden)

    Feng Hang

    2016-01-01

    Full Text Available Paenibacillus spp. BD3526, a bacterium exhibiting a protein hydrolysis circle surrounded with an obvious precipitation zone on skim milk agar, was isolated from raw yak (Bos grunniens milk collected in Tibet, China. Phylogenetic analysis based on 16S rRNA and whole genome sequence comparison indicated the isolate belong to the genus Paenibacillus. The strain BD3526 demonstrated strong ability to produce protease with milk clotting activity (MCA in wheat bran broth. The protease with MCA was predominantly accumulated during the late-exponential phase of growth. The proteolytic activity (PA of the BD3526 protease was 1.33-fold higher than that of the commercial R. miehei coagulant. A maximum MCA (6470 ± 281 SU mL−1 of the strain BD3526 was reached under optimal cultivation conditions. The protease with MCA was precipitated from the cultivated supernatant of wheat bran broth with ammonium sulfate and purified by anion-exchange chromatography. The molecular weight of the protease with MCA was determined as 35 kDa by sodium dodecyl sulfate-polyacrylamide gels electrophoresis (SDS-PAGE and gelatin zymography. The cleavage site of the BD3526 protease with MCA in κ-casein was located at the Met106–Ala107 bond, as determined by mass spectrometry analysis.

  9. Progress of German climate change policies until 2020. Report of the German Government for the assessment of projected progress in accordance with the implementation of the Kyoto Protocol - reporting in compliance to article 3(2) EU Directive 280/2004. Final report; Wirksamkeit des Klimaschutzes in Deutschland bis 2020. Bericht der Bundesregierung zur Bewertung des voraussichtlichen Fortschritts der Bundesrepublik Deutschland 2007 gemaess Umsetzung des Kyoto-Protokolls - Berichterstattung nach Artikel 3 Absatz 2 der EU-Richtlinie 280/2004. Endfassung

    Energy Technology Data Exchange (ETDEWEB)

    Erdmenger, Christoph; Kuhnhenn, Kai; Maue, Georg; Mayr, Sebastian (comps.)

    2008-03-15

    The report of the German Government on the projected progress in accordance with the implementation of the Kyoto Protocol with respect ton the progress of German climate policy until 2020 covers the following chapters: comparison of the scenarios without and with measures: description of the measures and instruments implemented in Germany and quantification of their efficacy (energy management, industry, commerce, trade, private households, traffic, agriculture, forestry); scenario with further measures: description of possible further measures and instruments for climate protection and quantification of their expected impacts; institutional measures and instrument concerning the Kyoto protocol; measures for participation in flexible mechanisms.

  10. Isolation and identification of berberine and berberrubine metabolites by berberine-utilizing bacterium Rhodococcus sp. strain BD7100.

    Science.gov (United States)

    Ishikawa, Kazuki; Takeda, Hisashi; Wakana, Daigo; Sato, Fumihiko; Hosoe, Tomoo

    2016-05-01

    Based on the finding of a novel berberine (BBR)-utilizing bacterium, Rhodococcus sp. strain BD7100, we investigated the degradation of BBR and its analog berberrubine (BRU). Resting cells of BD7100 demethylenated BBR and BRU, yielding benzeneacetic acid analogs. Isolation of benzeneacetic acid analogs suggested that BD7100 degraded the isoquinoline ring of the protoberberine skeleton. This work represents the first report of cleavage of protoberberine skeleton by a microorganism.

  11. Zwischen zwei Kulturen im Zeitraum von etwa 25 Jahren am Beispiel von Rafik Schami: heimatorientiert oder integriert? Arabische Emigrantenautoren in Deutschland

    Directory of Open Access Journals (Sweden)

    Eman Zakaria Mohammed Amer

    2015-05-01

    Full Text Available In den Noten und Abhandlungen zu besserem Verständnis des West-östlichen Divans (1819 zeichnet Goethe ein Selbstportrait als imaginärer Reisender, der „sich der fremden Landesart mit Neigung bequemt, […] Gesinnungen zu theilen, Sitten aufzunehmen versteht“ und der die „Rolle eines Handelsmanns“ übernimmt, „der seine Waaren gefällig auslegt und sie auf mancherley Weise angenehm zu machen sucht; ankündigende, beschreibende, ja lobpreisende Redensarten wird man ihm nicht verargen.“ Ende der 60er und Anfang der 70er Jahre des vorigen Jahrhunderts begannen Araber, nach Deutschland zu reisen, trotz der untiefen und schwachen kulturellen und geschichtlichen Verbindung mit der deutschen Kultur. Die damaligen politischen, wirtschaftlichen, sozialen und militärischen Unruhen in den arabischen Lӓndern wandelten viele Reisende in Emigraten. Man stimmt El-Wardy zu, dass man bislang nicht von einer zweiten oder dritten arabischen Schriftstellergeneration in Deutschland sprechen kann. Die arabischen Schriftsteller in Deutschland können aber in zwei Gruppen eingeteilt werden: Pioniere und spӓter Erschienene bzw. Jȕngere. Zwei Hauptthemen werden in der arabischen Emigratenliteratur behandelt: Der Orient und die Araber als Ausländer in Deutschland. Fremdheitserfahrungen zählen zu den zentralen Themen der interkulturellen und konkreter noch der Migrationsliteratur. Es geht dabei um Verschmelzung der Horizonte.Dass die arabischen Emigratenautoren ihre Werke auf Deutsch schreiben, bedeutet, die Deutschen anzusprechen.  

  12. 75 FR 14379 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG (RRD) Models Tay 620-15, Tay 650-15...

    Science.gov (United States)

    2010-03-25

    ... Deutschland Ltd & Co KG (RRD) Models Tay 620-15, Tay 650-15, and Tay 651-54 Turbofan Engines AGENCY: Federal...: Following a review of operational data of the Tay 651-54 engine, it has been found that the actual stress levels in the Tay 651- 54 engine High Pressure Compressor (HPC) stages 1, 3, 6, 7 and 12 discs were...

  13. Das Volkslied in Deutschland, Frankreich, Belgien und Holland. Untersuchungen über die Auffassung des Begriffes; Über die traditionellen Zeilen, die Zahlen-, Blumen- und Farbensymbolik

    NARCIS (Netherlands)

    Brouwer, Cornelis

    1930-01-01

    Wenn man die gewaltige Menge Publikationen über das Volkslied, die im Laufe des 19. und 20. Jahrhunderts in Deutschland, Frankreich, Belgien und Holland erschienen sind, vergleicht, springen zwei Punkte sofort ins Auge: 1. der Unterschied zwischen den verschiedenen Auffassungen vom Begriff Volkslied

  14. Precision Measurement of B(D+ -> mu+ nu) and the Pseudoscalar Decay Constant fD+

    CERN Document Server

    Eisenstein, B I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A G; Libby, J; Martin, L; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Méndez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P

    2008-01-01

    We measure the branching ratio of the purely leptonic decay of the D+ meson with unprecedented precision as B(D+ -> mu+ nu) = (3.82 +/- 0.32 +/- 0.09)x10^(-4), using 818/pb of data taken on the psi(3770) resonance with the CLEO-c detector at the CESR collider. We use this determination to derive a value for the pseudoscalar decay constant fD+, combining with measurements of the D+ lifetime and assuming |Vcd| = |Vus|. We find fD+ = (205.8 +/- 8.5 +/- 2.5) MeV. The decay rate asymmetry [B(D+ -> mu+ nu)-B(D- -> mu- nu)]/[B(D+ -> mu+ nu)+B(D- -> mu- nu)] = 0.08 +/- 0.08, consistent with no CP violation. We also set 90% confidence level upper limits on B(D+ -> tau+ nu) e+ nu) < 8.8x10^(-6).

  15. Managing the computational chemistry big data problem: the ioChem-BD platform.

    Science.gov (United States)

    Álvarez-Moreno, M; de Graaf, C; López, N; Maseras, F; Poblet, J M; Bo, C

    2015-01-26

    We present the ioChem-BD platform ( www.iochem-bd.org ) as a multiheaded tool aimed to manage large volumes of quantum chemistry results from a diverse group of already common simulation packages. The platform has an extensible structure. The key modules managing the main tasks are to (i) upload of output files from common computational chemistry packages, (ii) extract meaningful data from the results, and (iii) generate output summaries in user-friendly formats. A heavy use of the Chemical Mark-up Language (CML) is made in the intermediate files used by ioChem-BD. From them and using XSL techniques, we manipulate and transform such chemical data sets to fulfill researchers' needs in the form of HTML5 reports, supporting information, and other research media.

  16. Clinical Evaluation of the BD FACSPresto™ Near-Patient CD4 Counter in Kenya

    Science.gov (United States)

    Angira, Francis; Akoth, Benta; Omolo, Paul; Opollo, Valarie; Bornheimer, Scott; Judge, Kevin; Tilahun, Henok; Lu, Beverly; Omana-Zapata, Imelda; Zeh, Clement

    2016-01-01

    Background The BD FACSPresto™ Near-Patient CD4 Counter was developed to expand HIV/AIDS management in resource-limited settings. It measures absolute CD4 counts (AbsCD4), percent CD4 (%CD4), and hemoglobin (Hb) from a single drop of capillary or venous blood in approximately 23 minutes, with throughput of 10 samples per hour. We assessed the performance of the BD FACSPresto system, evaluating accuracy, stability, linearity, precision, and reference intervals using capillary and venous blood at KEMRI/CDC HIV-research laboratory, Kisumu, Kenya, and precision and linearity at BD Biosciences, California, USA. Methods For accuracy, venous samples were tested using the BD FACSCalibur™ instrument with BD Tritest™ CD3/CD4/CD45 reagent, BD Trucount™ tubes, and BD Multiset™ software for AbsCD4 and %CD4, and the Sysmex™ KX-21N for Hb. Stability studies evaluated duration of staining (18–120-minute incubation), and effects of venous blood storage <6–24 hours post-draw. A normal cohort was tested for reference intervals. Precision covered multiple days, operators, and instruments. Linearity required mixing two pools of samples, to obtain evenly spaced concentrations for AbsCD4, total lymphocytes, and Hb. Results AbsCD4 and %CD4 venous/capillary (N = 189/ N = 162) accuracy results gave Deming regression slopes within 0.97–1.03 and R2 ≥0.96. For Hb, Deming regression results were R2 ≥0.94 and slope ≥0.94 for both venous and capillary samples. Stability varied within 10% 2 hours after staining and for venous blood stored less than 24 hours. Reference intervals results showed that gender—but not age—differences were statistically significant (p<0.05). Precision results had <3.5% coefficient of variation for AbsCD4, %CD4, and Hb, except for low AbsCD4 samples (<6.8%). Linearity was 42–4,897 cells/μL for AbsCD4, 182–11,704 cells/μL for total lymphocytes, and 2–24 g/dL for Hb. Conclusions The BD FACSPresto system provides accurate, precise clinical

  17. Folding Behaviour for Proteins BBL and E3BD with Gō-like Models

    Institute of Scientific and Technical Information of China (English)

    ZUO Guang-Hong; ZHANG Jian; WANG Jun; WANG Wei

    2005-01-01

    @@ Folding behaviour of protein BBL and its homologue domain E3BD are studied by using an off-lattice Gō-like model. It is found that the folding behaviours of these two proteins are different. Protein BBL folds in a downhill manner, which is consistent with experiments. In contrast, protein E3BD folds cooperatively and has a bimodal distribution of the Q values (the similarity to the native state). By analysing the native structures of the two proteins, it is found that the difference in folding behaviours can be attributed to the different structural features described by the number of nonlocal contacts per residue.

  18. Comparison of positioning accuracy of GPS and BD2 in the South China Sea%南海海域BD2与 GPS定位精度比对

    Institute of Scientific and Technical Information of China (English)

    张永超; 徐国贵; 李帅

    2015-01-01

    The economic benefits of the BD2 are growing .It analysis the positioning difference of GPS and BD2 by using a higher positioning accuracy of GPS receiver and a set of BD 2 e‐quipment which has low power consumption and low cost .The test includes the north and the east of the south China sea .In the test zone ,when positioning accuracy of GPS and BD2 is higher ,the positioning difference of GPS and BD2 is about 3 meters .In the east of the south China sea ,BD2 has been bad in a long time ,but the positioning difference of GPS and BD2 is less than 25 meters .So we can get a conclusion that BD2 can meet the needs of the navigation of ships and position of some M arine equipment .%试验中利用一套定位精度相对较高的G PS设备和一套市场上适用,低功耗、低成本北斗设备,分析G PS和BD2定位差值。所选试验区域包含了南海北部海域和南海东部海域。在这两个区域,当G PS与BD2定位精度较高时,二者定位差值在3m左右。在南海东部海域,BD2出现定位精度不好的情况且时间较长,但定位差值在25m以内。故间接可以说明北斗导航系统能够满足船舶航行以及一些海上仪器设备定位需要。

  19. Biodegradable plastics. A contribution to promoting composting in Germany; Bioabbaubare Kunststoffe. Ein Beitrag zur Foerderung der Kompostierung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Hamprecht, Jens [BASF SE, Ludwigshafen (Germany)

    2012-11-01

    Up to 80% of all Germans use newspapers for collecting biomass waste, even if it is unhygienic and the paper will soak. This is just one of the many examples of the Germans' readiness to separate waste fractions and save resources. Separation of biomass waste and composting is another field where Germany is ahead of other countries, but the potential is still not fully utilized by far. More hygienic collecting of biomass waste would be possible if biodegradable plastic containers were used. (orig.) [German] Bis zu 80% der Buerger in Deutschland verwenden bisher Zeitung zum Sammeln von Bioabfaellen, selbst wenn es unhygienisch ist und die Zeitung leicht durchweicht. Und das ist nur einer von vielen Beweisen fuer die hohe Bereitschaft der Deutschen zur Abfalltrennung und damit zur Ressourcenschonung. Kein Wunder also, dass in Deutschland auch die Bioabfalltrennung und Kompostierung im Vergleich zu anderen Laendern sehr weit entwickelt ist. Trotzdem ist das Potential noch bei weitem nicht ausgeschoepft. Mit Hilfe von bioabbaubaren Kunststoffen kann den Buergern eine hygienischere Sammlung von Bioabfall ermoeglicht werden. (orig.)

  20. Energy efficiency in Germany - a meta-analysis. Analysis and recommendations; Energieeffizienz in Deutschland - eine Metastudie. Analyse und Empfehlungen

    Energy Technology Data Exchange (ETDEWEB)

    Bauernhansl, Thomas (ed.) [Stuttgart Univ. (Germany). Inst. fuer Energieeffizienz in der Produktion (EEP)

    2014-07-01

    The Stuttgart Institute of energy efficiency in production compiled the first meta-analysis ''Energy Efficiency in Germany''.It provides facts and figures on the development atatus and knowledge level of energy efficiency in Germany. The study shows the contribution have been made by individual measures and the potentials which are known, but have not yet been lifted. For this meta-analysis more than 250 items available from research institutions, government departments, professional and industry associations have been identified with the main topic of energy efficiency and evaluated. It provides an overview of the status of development and is an important reference work for industry, associations and politics. [German] Das Stuttgarter Institut fuer Energieeffizienz in der Produktion hat die erste Metastudie ''Energieeffizienz in Deutschland'' erarbeitet. Sie liefert Zahlen, Daten und Fakten zum Entwicklungs- und Kenntnisstand der Energieeffizienz in Deutschland. Die Studie zeigt auf, welchen Beitrag einzelne Massnahmen bisher geleistet haben und welche Potenziale zwar bekannt sind, aber bisher noch nicht gehoben wurden. Fuer diese Metastudie wurden mehr als 250 Veroeffentlichungen von Forschungseinrichtungen, Ministerien, Fach- und Industrieverbaenden mit Themenschwerpunkt Energieeffizienz identifiziert und ausgewertet. Sie bietet einen Ueberblick ueber den Stand der Entwicklung und ist ein wichtiges Nachschlagewerk fuer Industrie, Verbaende und Politik.

  1. Environmental survey 1998. Vol. 3: Human biomonitoring. Concentrations of substances in blood and urine of the German population; Umwelt-Survey 1998. Bd. 3: Human-Biomonitoring. Stoffgehalte in Blut und Urin der Bevoelkerung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Becker, K.; Kaus, S.; Krause, C.; Lepom, P.; Schulz, C.; Seiwert, M.; Seifert, B.

    2002-03-01

    The occurrence of precious metals in the environment is increasing, due primarily to their use in catalytic converters for motor vehicles, and they were therefore integrated into the study programme in 1998. Urine samples of 1080 subjects were analysed for gold, platinum and iridium, resulting in mean concentrations of 46 ng/l, 2.2 ng/l and 0.2 ng/l. The number of dental inlays, crowns and bridge elements has a clear influence on the mean levels of gold and platinum in urine. Road traffic was not found to be a signficant factor. Nicotine and cotinine are common markers for exposure to tobacco smoke. Non-smokers exhibit a mean nicotine level in urine of less than 2 {mu}g/l and a cotinine level of less than 4 {mu}gl. Nicotine and cotinine levels in urine increase as a function of the number of cigarettes smoked per day, reaching values of 1080 {mu}g/l and 2060 {mu}g/l, respectively, when consumption exceeds 20 cigarettes per day. Exposure to environmental tobacco smoke is also reflected by nicotine and cotinine levels in urine. The present report provides representative data for environmentally related health monitoring and reporting at national level. The data serve as the basis for the formulation of reference values characterising the population's internal exposure to environmental contaminants. The report shows trends over time and regional differences in pollution, and identifies exposure pathways. The results of the Environmental Survey serve inter alia to achieve nationally harmonised methodologies for assessment, health-related environmental reporting, and the development and monitoring of prevention, intervention and abatement strategies within the scope of health and environmental policy actions. (orig.)

  2. The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

    Science.gov (United States)

    Bailleul, Geoffrey; Kravtzoff, Amanda; Joulin-Giet, Alix; Lecaille, Fabien; Labas, Valérie; Meudal, Hervé; Loth, Karine; Teixeira-Gomes, Ana-Paula; Gilbert, Florence B.; Coquet, Laurent; Jouenne, Thierry; Brömme, Dieter; Schouler, Catherine; Landon, Céline; Lalmanach, Gilles; Lalmanach, Anne-Christine

    2016-01-01

    Defensins are frontline peptides of mucosal immunity in the animal kingdom, including birds. Their resistance to proteolysis and their ensuing ability to maintain antimicrobial potential remains questionable and was therefore investigated. We have shown by bottom-up mass spectrometry analysis of protein extracts that both avian beta-defensins AvBD2 and AvBD7 were ubiquitously distributed along the chicken gut. Cathepsin B was found by immunoblotting in jejunum, ileum, caecum, and caecal tonsils, while cathepsins K, L, and S were merely identified in caecal tonsils. Hydrolysis product of AvBD2 and AvBD7 incubated with a panel of proteases was analysed by RP-HPLC, mass spectrometry and antimicrobial assays. AvBD2 and AvBD7 were resistant to serine proteases and to cathepsins D and H. Conversely cysteine cathepsins B, K, L, and S degraded AvBD2 and abolished its antibacterial activity. Only cathepsin K cleaved AvBD7 and released Ile4-AvBD7, a N-terminal truncated natural peptidoform of AvBD7 that displayed antibacterial activity. Besides the 3-stranded antiparallel beta-sheet typical of beta-defensins, structural analysis of AvBD7 by two-dimensional NMR spectroscopy highlighted the restricted accessibility of the C-terminus embedded by the N-terminal region and gave a formal evidence of a salt bridge (Asp9-Arg12) that could account for proteolysis resistance. The differential susceptibility of avian defensins to proteolysis opens intriguing questions about a distinctive role in the mucosal immunity against pathogen invasion. PMID:27561012

  3. 13 CFR 124.3 - What definitions are important in the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... identifies and markets a requirement which is subsequently offered to the 8(a) BD program as an open... specified. Day-to-day operations of a firm means the marketing, production, sales, and administrative... the individuals who manage the concern's day-to-day operations spend most working hours and where top...

  4. Vitamin B@d12@@ concentrations in Mandovi and Zuari estuaries

    Digital Repository Service at National Institute of Oceanography (India)

    DeSilva, C.; Rajendran, A.

    and between 0.12 and 0.49 ng/l in bottom samples. Near the head of the estuary, the variation in B@d12@@ concentration was from nil to 2.47 ng/l. Relatively lower concentration was observed (0.20 to 1.06 ng/l) at the head of this estuary. Various probable...

  5. ISO Spectroscopy of Young Intermediate-Mass Stars in the BD+40 4124 Group

    CERN Document Server

    Van den Ancker, M E; Tielens, A G G M

    2000-01-01

    We present the results of ISO SWS and LWS grating scans towards the three brightest members of the BD+40 4124 group in the infrared: BD+40 4124 (B2Ve), LkHalpha 224 (A7e) and the embedded source LkHalpha 225. Emission from the pure rotational lines of H_2, from ro-vibrational transitions of CO, from PAHs, from H I recombination lines and from the infrared fine structure lines of [Fe II], [Si II], [S I], [O I], [O III] and [C II] was detected. These emission lines arise in the combination of a low-density (approx 10^2 cm^-3) H II region with a clumpy PDR in the case of BD+40 4124. The lower transitions of the infrared H I lines observed in BD+40 4124 are optically thick; most likely they arise in either a dense wind or a circumstellar disk. This same region is also responsible for the optical H I lines and the radio continuum emission. In the lines of sight towards LkHalpha 224 and LkHalpha 225, the observed emission lines arise in a non-dissociative shock produced by a slow (approx 20 km/s) outflow arising fr...

  6. An Extraction of Vcb from the Semi-Leptonic B->D* Decay

    CERN Document Server

    Hazel, N M

    1994-01-01

    We present an extraction of Vcb from a lattice calculation of the B->D* decay matrix elements. We obtain |Vcb| \\sqrt{ \\frac{ \\tauB }{ 1.49 ps } } = 0.037^{+3 \\ +5}_{-3 \\ -5} from a single parameter fit to the new CLEO data. Email nmh@uk.ac.ed.ph.th

  7. Data of evolutionary structure change: 1JJWC-2Z3BD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1JJWC-2Z3BD 1JJW 2Z3B C D -----TTIVSVRRNGQVVVGGDGQVSLG-NTVMKGNARK...EEE HHHHHHHHHHHHHH HHHHHHHHHHHHHHH EEE 0 1JJ...W C 1JJWC QVSLG-NT...l> 1 1JJW C 1JJ...ne>ILE CA 426 LEU CA 426 ALA CA 469 1JJ

  8. Die Deutsche Zentralbibliothek für Medizin in Köln und Bonn – Zentrale Fachbibliothek und Infrastruktureinrichtung für die Forschung in der Bundesrepublik Deutschland / The German National Library of Medicine in Cologne and Bonn – National Library and Infrastructure Organisation for Research in the Federal Republic of Germany

    Directory of Open Access Journals (Sweden)

    Korwitz, Ulrich

    2009-01-01

    Full Text Available The German National Library of Medicine (ZB MED is the National Library for Medicine, Health, Nutrition, Environment and Agriculture in the Federal Republic of Germany. Founded 40 years ago, the library developed from a document supplier on the basis of its comprehensive collection to an infrastructure organisation especially for scientific users. Today, the emphasis is put – besides collection management and document delivery – on modern information services, Open Access Publishing and innovative projects.

  9. Der Unterricht zur Arzt-Patientin-Beziehung (APB im Fach Medizinische Soziologie an den medizinischen Fakultäten der Bundesrepublik Deutschland nach Änderung der Approbationsordnung für ��rzte [Teaching the doctor-patient relationship in medical sociology within German medical faculties following revisions to licensing regulations for physicians

    Directory of Open Access Journals (Sweden)

    Kiessling, Claudia

    2008-11-01

    Full Text Available [english] Background: Changes in requirements governing licensing regulations for physicians in Germany (ÄAppO in 2002, has led to complex discussions within the German Society of Medical Sociology (DGMS. In order to support the process of curricular agreement, the DGMS workgroup entitled ‘teaching’ conducted a survey on how the doctor–patient relationship is taught in medical sociology. Method: The survey was conducted in spring 2005 via e-mail. A standardized questionnaire including a total of thirty educational objectives comprised the survey, whereby each objective was evaluated by five criteria. Thirteen experts in the field of medical sociology variously representing eleven medical faculties responded. According to suggested methods of the Delphi survey, means and ranges were calculated. Results: Of the thirty educational objectives surveyed, two were evaluated negatively by a majority of individuals. Twenty objectives showed variances in evaluation (i.e., controversial objectives. Eight objectives, for example, the social framing of the doctor–patient relationship, the elaborateness of language use, or the asymmetry of the doctor–patient relationship, were generally judged positively. Controversial objectives revealed some areas of contradiction. Some objectives – for example, exploring the social background of a patient – were evaluated as important items but were not frequently taught during regular sociology courses. Conclusions: The results show an interesting picture of present teaching practices in eleven medical faculties and will likely stimulate further discussion in the field of medical sociology. The response rate and discussions held in recent years demonstrate the need to discuss questions of relevance to medical education before a wider audience, both within the DGMS and other disciplines. Educational objectives and didactic methods need to be further developed to bring teaching in step with actual practice as well as to make it more multifaceted. [german] Hintergrund: Die 2002 eingeführte neue Ärztliche Approbationsordnung (ÄAppO löste in der Fachgesellschaft Deutsche Gesellschaft für Medizinische Soziologie e.V. (DGMS eine vielschichtige Diskussion aus. Um den Prozess der curricularen Verständigung zu forcieren, wurde von der AG Lehre der DGMS eine Befragung zum Thema Arzt-Patientin-Beziehung im medizinsoziologischen Unterricht durchgeführt. Methode: Die Befragung fand im Frühjahr 2005 per E-Mail statt. Instrument war ein standardisierter Fragebogen mit insgesamt dreißig Lernzielen, welche nach fünf Kriterien beurteilt werden sollten. Insgesamt 13 ExpertInnen aus Instituten der Medizinischen Soziologie an elf Medizinischen Fakultäten antworteten auf die Befragung. Die Daten wurden EDV-gestützt erfasst. In Anlehnung an die für Delphiverfahren empfohlenen Methoden wurden arithmetische Mittel und Streuungsmaße berechnet. Ergebnisse: Von den insgesamt dreißig Lernzielen wurden zwei von der Majorität der Befragten negativ beurteilt. Zwanzig weitere zeigten Beurteilungsvarianzen. Acht Lernziele, wie die soziale Rahmung der Arzt-Patientin-Beziehung, die elaborierte Sprache oder auch die Asymmetrie der Arzt-Patientin-Beziehung, wurden kollektiv positiv eingeschätzt. Bei den Lernzielen mit Beurteilungsvarianzen werden Widersprüche sichtbar. Bei einigen Lernzielen, wie etwa der Erhebung einer Sozialanamnese, klaffen erkannte Relevanz und praktische Umsetzung auseinander. Schlussfolgerungen: Die Ergebnisse bezüglich der gegenwärtigen Lehrpraxis zum Thema Arzt-Patientin-Beziehung an elf Medizinischen Fakultäten geben Orientierungen für weiterführende Diskussionen in der Medizinischen Soziologie. Zum einen führen die Antwortquote und die Diskussionspraxis der letzten Jahre zu der Schlussfolgerung, dass die Diskussion in der Fachgesellschaft über den Kreis der Fachvertreter resp. der langjährig in der Lehre Tätigen hinaus geführt werden sollte. Zum anderen zeigen die Ergebnisse, dass eine auf unterschiedlichen Ebenen geführte Diskussion dazu führen kann, den Unterricht noch praxisnäher und inhaltlich facettenreicher zu gestalten.

  10. ''Confession statement against the nuclear nation''. The protestant church in Germany and the conflicts concerning nuclear energy 1970 - 1990; ''Bekennen gegen den Atomstaat''. Die evangelischen Kirchen in der Bundesrepublik Deutschland und die Konflikte um die Atomenergie 1970-1990

    Energy Technology Data Exchange (ETDEWEB)

    Schuering, Michael [Florida Univ., Gainesville, FL (United States)

    2015-07-01

    The book on ''Confession statement against the nuclear nation'' discusses the conflicts of the protestant church in Germany concerning nuclear energy in 1970 - 1990. The introduction covers the state of research and the historical sources. The following chapters discuss the issues philosophic-ideological fundamentals: atomic energy and theology, the political church, the new protest culture and comparative perspectives: the catholic perspective, Three Mile Island's shadow.

  11. CJEU - Judgment of 23.9.2013 (grand chamber) - Case c-221/11 leyla Demirkan v Bundesrepublik Deutschland - Association agreement with Turkey - Article 41 of the additional protocol -freedom to provide services - Visa requirement: Turkey association agreement does not cover passive reception of services and Turkish nationals wishing to enter the Schengen area cannot benefit from this freedom

    NARCIS (Netherlands)

    Matera, C.

    2014-01-01

    With the Demirkan case the CJEU was called upon to clarify the scope of Article 41(1) of the Additional protocol to the EU - Turkey Association Agreement and affirm whether the Soysal and Savatli ruling was also applicable to the passive reception of services and, more specifically, to tourists. The

  12. Convention on Nuclear Safety - CNS. Report by the government of the Federal Republic of Germany for the seventh review conference in March/April 2017; Uebereinkommen ueber nukleare Sicherheit. Bericht der Regierung der Bundesrepublik Deutschland fuer die Siebte Ueberpruefungstagung im Maerz/April 2017

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-06-22

    The CNS (Convention on Nuclear Safety) report by the government of the Federal Republic of Germany for the seventh review conference in March/April 2017 covers the following topics: Summary of the most important results since the sixth review conference: existing nuclear facilities, frame for legislation and execution, licensing system, regulatory authority, governmental organizations, responsibility of the licensee, priority of safety, financing and personnel, human factors, quality assurance, safety assessment, radiation protection, emergency preparedness, site selection for nuclear facilities, design and construction, operation.

  13. Substitution of R502 in existing refrigerating, air-conditioning and heat pump systems with refrigerants of low ozone depletion potential in the Federal Republic of Germany; Ersatz von R 502 in bestehenden Kaelte-, Klima- und Waermepumpenanlagen in der Bundesrepublik Deutschland durch Kaeltemittel mit geringerem Ozonabbaupotential

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The technical basics and the state of engineering for the substitution of R502 in existing refrigeration systems are described and explained. The report contains an overview of the current applications of R502 in the FRG, the presentation and discussion of existing substitutes, the presentation and valuations of research and experiences with the adaptation to alternative refrigerants, the presentation of the required infrastructure and a discussion of the technical feasibility. The conversion of existing systems to refrigerants of lower ozone depletion potential is in conclusion valuated with regard to its technical feasibility, environmental relevance and economic efficiency. (orig.) [Deutsch] Es werden die technischen Grundlagen und der Stand der Technik zum Ersatz von R502 in bestehenden Kaelteanlagen dargestellt und erlaeutert. Der Bericht beinhaltet einen Ueberblick ueber die derzeitige Anwendung von R502 in der BRD, die Vorstellung und Diskussion existierender Ersatzstoffe, die Darstellung und Bewertung der Forschung und Erfahrungen zu Umruestungen auf Ersatzstoffe, die Vorstellung der erforderlichen Infrastruktur und die Diskussion der technischen Durchfuehrbarkeit. Die Umstellung bestehender Anlagen auf Kaeltemittel mit geringerem Ozonabbaupotential wird abschliessend hinsichtlich der technischen Durchfuehrbarkeit, der Umweltrelevanz und der Wirtschaftlichkeit bewertet. (orig.)

  14. The long-term behaviour of the herbicides chloridazon and 2,4-DP-P after application according to good agricultural practice in two different soils of the Federal Republic of Germany. Das Langzeitverhalten der Herbizidwirkstoffe Chloridazon und 2,4-DP-P nach Praxisanwendung in zwei verschiedenen Boeden der Bundesrepublik Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Gatzweiler, E.

    1994-04-01

    The long-term behaviour of the herbicides [4,5-[sup 14]C]chloridazon and [phenyl-U-[sup 14]C]2,4-DP-P was studied in lysimeters (profile depth 1.1 m) with a degraded loess soil (Parabraunerde - CH1 and DP1) and a pseudogley brown soil (Pseudogley-Braunerde - CH2 and DP2) over a two years period under field conditions. Chloridazon was applied by preemergence to sugar beets and 2,4-DP-P by postemergence to spring wheat. The crop husbandry was conducted in accordance with good agricultural practice in both crop rotations of sugar beets-winter wheat-winter barley (chloridazon for CH1 and CH2) and spring wheat-winter barley-winter rape (2,4-DP-P for DP1 and DP2). In addition, the degradation, metabolization and mineralization of the active ingredients (chloridazon for CH3 and CH4; 2,4-DP-P for DP3 and DP4) were studied in standardized experiments with both soils. Due to its particular significance as a chloridazon degradation product, [4,5-[sup 14]C]metabolite B was observed in an 80-day degradation study (MB1, MB2+S and MB2-S) exclusively in the degraded loess soil. (orig./UHE)

  15. Convention on Nuclear Safety - CNS. Report by the government of the Federal Republic of Germany for the sixth review conference in March/April 2014; Uebereinkommen ueber nukleare Sicherheit. Bericht der Regierung der Bundesrepublik Deutschland fuer die Sechste Ueberpruefungstagung im Maerz/April 2014

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-01

    The report by the government of the Federal Republic of Germany for the sixth review conference (Convention on Nuclear Safety - CNS) in March/April 2014 covers the following issues: reappraisal of nuclear energy in the Federal Republic of Germany; measures as consequence of the reactor accident in the nuclear power plant Fukushima; safety regulations; execution of the IRRS follow-up mission in Germany; safety management and technical qualification of the occupational personnel; safety surveillance; radiation protection, overview on important safety topics; events and incidents larger INES 0. Assessment of the existing nuclear facilities; progress and changes since 2011; future activities.

  16. The development of engineered safeguards for nuclear power plants in the political and technical environment in the Federal Republic of Germany since 1955; Die Entwicklung der Sicherheitstechnik fuer Kernkraftwerke im politischen und technischen Umfeld der Bundesrepublik Deutschland seit dem Jahr 1955

    Energy Technology Data Exchange (ETDEWEB)

    Laufs, P. [Stuttgart Univ. (Germany). Philosophische-Historische Fakultaet

    2007-01-15

    The safety of nuclear power plants is determined largely by the integrity of the internally pressurized coolant containment system. The highly radioactive materials (fission products) generated within this pressurized containment (primary system) in the reactor core during nuclear power plant operation constitute an extremely great potential hazard. Catastrophic failure of the primary system, and the release into the environment of the radioactive inventory, must be avoided at all costs. Because of the high coolant pressure and the high power density, pressurized water reactors (PWR) impose particularly strict requirements with respect to reactor safety. German nuclear power plants equipped with light water reactors enjoy the reputation of being among the safest plants in the world. This frequent statement is justified in the light of the research and development work performed jointly by industry, government agencies, science, and expert bodies between the 1960s and the 1990s. The research projects, which implied considerable financial expenditures, their internationally acknowledged results, and the resultant additional backfitting measures conducted in German nuclear power plants at many billions of expenditures, were hardly noticed by the German body politic. (orig.)

  17. DerSchutz des geistigen Eigentums in der Verfassung der Bundesrepublik Deutschland und der zRechtsordnumg der Republik Indonesien (Defense of Intellectual Property in the Constitution of the Federal Republic of Germany and the Legal System of the Republic on Indonesia)

    Science.gov (United States)

    2000-01-01

    This dissertation can be divided into eight chapters: 1) the place of the right of intellectual property in the German legal system ; 2) the history...Law; 5) the basic legal guarantee of personality-related aspects of intellectual property; 6) intellectual property in the Indonesian legal system ; 7

  18. Agreements concluded by the Federal Republic of Germany under international law in the field of environmental protection. Source index in the Federal Law Gazette, part II. As of June 1, 1992. Voelkerrechtliche Vereinbarungen der Bundesrepublik Deutschland auf dem Gebiet des Umweltschutzes. Fundstellen im Bundesgesetzblatt II. Stand 1. Juni 1992

    Energy Technology Data Exchange (ETDEWEB)

    Lohse, S. (comp.)

    1992-06-01

    This compilation contains all agreements under international law in the field of environmental protection, the FRG has joined and that have been published and/or announced in the Federal Law Gazette, part II. The summary is of September 15, 1987. The classification is made according to the subjects: waste management law, pollution is made according to the date of treaty/agreement. For easier access, there are a chronological index, an index of the contracting states and an index of the places of contract. In the annex the relevant treaties with the German Democratic Republic are indicated. (orig.)

  19. Substitution of R502 in existing refrigerating, air-conditioning and heat pump systems with refrigerants of low ozone depletion potential in the Federal Republic of Germany; Ersatz von R 502 in bestehenden Kaelte-, Klima- und Waermepumpenanlagen in der Bundesrepublik Deutschland durch Kaeltemittel mit geringerem Ozonabbaupotential

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The technical basics and the state of engineering for the substitution of R502 in existing refrigeration systems are described and explained. The report contains an overview of the current applications of R502 in the FRG, the presentation and discussion of existing substitutes, the presentation and valuations of research and experiences with the adaptation to alternative refrigerants, the presentation of the required infrastructure and a discussion of the technical feasibility. The conversion of existing systems to refrigerants of lower ozone depletion potential is in conclusion valuated with regard to its technical feasibility, environmental relevance and economic efficiency. (orig.) [Deutsch] Es werden die technischen Grundlagen und der Stand der Technik zum Ersatz von R502 in bestehenden Kaelteanlagen dargestellt und erlaeutert. Der Bericht beinhaltet einen Ueberblick ueber die derzeitige Anwendung von R502 in der BRD, die Vorstellung und Diskussion existierender Ersatzstoffe, die Darstellung und Bewertung der Forschung und Erfahrungen zu Umruestungen auf Ersatzstoffe, die Vorstellung der erforderlichen Infrastruktur und die Diskussion der technischen Durchfuehrbarkeit. Die Umstellung bestehender Anlagen auf Kaeltemittel mit geringerem Ozonabbaupotential wird abschliessend hinsichtlich der technischen Durchfuehrbarkeit, der Umweltrelevanz und der Wirtschaftlichkeit bewertet. (orig.)

  20. CJEU - Judgment of 23.9.2013 (grand chamber) - Case c-221/11 leyla Demirkan v Bundesrepublik Deutschland - Association agreement with Turkey - Article 41 of the additional protocol -freedom to provide services - Visa requirement: Turkey association agreement does not cover passive reception of services and Turkish nationals wishing to enter the Schengen area cannot benefit from this freedom

    NARCIS (Netherlands)

    Matera, Claudio

    2014-01-01

    With the Demirkan case the CJEU was called upon to clarify the scope of Article 41(1) of the Additional protocol to the EU - Turkey Association Agreement and affirm whether the Soysal and Savatli ruling was also applicable to the passive reception of services and, more specifically, to tourists. The

  1. The nuclear fuel cycle in France and in the Federal Republic of Germany. Report about the joint SFEN/KTG meeting held at the Karlsruhe Nuclear Research Center on November 20-21, 1989. Entwicklungen im nuklearen Brennstoffkreislauf in Frankreich und der Bundesrepublik Deutschland. Bericht ueber die deutsch-franzoesische Tagung der SFEN und der KTG am 20. /21. 11. 89 im Kernforschungszentrum Karlsruhe

    Energy Technology Data Exchange (ETDEWEB)

    Kroebel, R. (Kernforschungszentrum Karlsruhe GmbH (Germany, F.R.). Projekt Wiederaufarbeitung und Abfallbehandlung); Wigger, B. (Badenwerk AG, Karlsruhe (Germany, F.R.))

    1990-02-01

    The meeting was intended as a platform for comparing and assessing the current situation in the nuclear fuel cycle of LWRs in France and West Germany. The subjects discussed centered on fuel element development and reactor charging strategies, and on the situation in the spent fuel reprocessing sector which has experienced interesting developments. The different approaches adopted in the two countries for ultimate waste disposal were another conference topic. A decisive difference in the conditions of the two countries is that, although the relevant political decisions have been taken at about the same time, the conditions in France were such that by now, all steps in the nuclear fuel cycle have developed to an economically profitable stage, whereas the nuclear controversy in West Germany, and the related deficit in public acceptance, have hampered and delayed the corresponding developments in this country. (orig.).

  2. Molecular characterization and functional analysis of BdFoxO gene in the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae).

    Science.gov (United States)

    Wu, Yi-Bei; Yang, Wen-Jia; Xie, Yi-Fei; Xu, Kang-Kang; Tian, Yi; Yuan, Guo-Rui; Wang, Jin-Jun

    2016-03-10

    The forkhead box O transcription factor (FoxO) is an important downstream transcription factor in the well-conserved insulin signaling pathway, which regulates the body size and development of insects. In this study, the FoxO gene (BdFoxO) was identified from the oriental fruit fly, Bactrocera dorsalis (Hendel). The open reading frame of BdFoxO (2732 bp) encoded a 910 amino acid protein, and the sequence was well conserved with other insect species. The BdFoxO was highly expressed in larvae and pupae among different development stages, and the highest tissue-specific expression level was found in the fat bodies compared to the testis, ovary, head, thorax, midgut, and Malpighian tubules of adults. Interestingly, we found BdFoxO expression was also up-regulated by starvation, but down-regulated when re-fed. Moreover, the injection of BdFoxO double-stranded RNAs into third-instar larvae significantly reduced BdFoxO transcript levels, which in turn down-regulated the expression of other four genes in the insulin signaling pathway. The silencing of BdFoxO resulted in delayed pupation, and the insect body weight increased significantly compared with that of the control. These results suggested that BdFoxO plays an important role in body size and development in B. dorsalis. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Ecotoxicological sediment survey of large German rivers; Oekotoxikologische Sedimentkartierung der grossen Fluesse Deutschlands

    Energy Technology Data Exchange (ETDEWEB)

    Duft, M.; Tillmann, M. [Internationales Hochschulinstitut Zittau (Germany); Oehlmann, J. [Frankfurt Univ. (Germany). Zoologisches Inst., Abt. Oekologie und Evolution

    2003-05-01

    In this project, a nation-wide, ecotoxicologically-based sediment survey was carried out. For this purpose, a total of about 200 sediment samples from 12 selected large German rivers (Danube, Elbe, Ems, Main, Mosel, Neckar, Neisse, Odra, Rhine, Ruhr, Saar and Weser) were analysed with regard to abiotic parameters (heavy metals, PAH, organic carbon content, particle size) and also by means of two biological test systems with benthic invertebrates (nematode test with the roundworm Caenorhabditis elegans and chironomid test with the non-biting midge Chironomus riparius). Subsequently, this comprehensive data set was analysed statistically. By means of an iterative method, a five-stage, statistically-derived assessment concept which is founded on the results of the biological tests, was developed following the EU water framework directive. In general, the classification with the nematode test turned out to be the more sensitive method. A principal component analysis and correlations showed that the parameters of both biotests provide different information which suggests a combined use of both tests. Correlations also indicate a connection of biotest results and abiotic parameters (organic carbon content, particle size and heavy metal contamination). (orig.) [German] Im Projekt wurde eine bundesweite oekotoxikologische Sedimentkartierung grosser Fliessgewaesser durchgefuehrt. Dazu wurden insgesamt etwa 200 Sedimentproben aus 12 ausgewaehlten grossen Fluessen Deutschlands (Donau, Elbe, Ems, Main, Mosel, Neckar, Neisse, Oder, Rhein, Ruhr, Saar und Weser) auf ihre abiotischen Parameter (Schwermetalle, PAK, organischer Kohlenstoffgehalt, Korngroesse) hin analysiert sowie mit zwei biologischen Testverfahren mit benthischen Invertebraten (Nematodentest mit dem Fadenwurm Caenorhabditis elegans und Chironomidentest mit der Zuckmuecke Chironomus riparius) untersucht. Dieses umfangreiche Datenmaterial wurde anschliessend statistisch ausgewertet und mit Hilfe eines iterativen

  4. The orbits of subdwarf-B + main-sequence binaries. II. Three eccentric systems; BD+29 3070, BD +34 1543 and Feige 87

    CERN Document Server

    Vos, J; Nemeth, P; Green, E M; Heber, U; Van Winckel, H

    2013-01-01

    The predicted orbital-period distribution of the subdwarf-B (sdB) population is bi-modal with a peak at short ( 250 days) periods. Observationally, many short-period sdB systems are known, but the predicted long period peak is missing as orbits have only been determined for a few long-period systems. As these predictions are based on poorly understood binary-interaction processes, it is of prime importance to confront the predictions with reliable observational data. We therefore initiated a monitoring program to find and characterize long-period sdB stars. In this paper we aim to determine the orbital parameters of the three long-period sdB+MS binaries BD+29 3070, BD+34 1543 and Feige 87, to constrain their absolute dimensions and the physical parameters of the components. High-resolution spectroscopic time series were obtained with HERMES at the Mercator telescope on La Palma, and analyzed to determine the radial velocities of both the sdB and MS components. Photometry from the literature was used to constr...

  5. A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways.

    Science.gov (United States)

    Li, Min-Hui; Yang, Ping; Yang, Tai; Zhang, Kun; Liu, Yang; Liu, Jin; Li, Li-Mei; Luo, Xing-Yan; Yang, Shu-Xia; Zou, Qiang; Zhang, Chong-Jie

    2016-11-01

    Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy have received considerable attention in recent years. However, the poor water solubility of most benzothiazole derivatives has limited their clinical application. We developed BD926, a novel water-soluble benzothiazole derivative and showed here that it could inhibit the proliferation and induce apoptosis of human Ramos B-lymphoma cells. We further showed that BD926 triggered apoptosis through both mitochondria and endoplasmic reticulum pathways. Moreover, BD926 caused cell cycle arrest at G0/G1 stage. Furthermore, accumulation of reactive oxygen species (ROS) were observed after BD926 treatment and ROS inhibitor was able to attenuate BD926-induced apoptosis, which suggested that BD926-induced apoptosis may be due to over-producing ROS. These results demonstrate the anticancer effects of BD926 in cell models and raise the possibility for the application of BD926 in cancer therapy.

  6. Genderidentitäten in Deutschland und der Türkei Gender Identities in Germany and Turkey

    Directory of Open Access Journals (Sweden)

    Karin Schweißgut

    2004-07-01

    Full Text Available Das Verhältnis der Geschlechter und insbesondere die Rolle der Frau stehen im Fokus der gegenseitigen Wahrnehmung von Deutschen und Türken. Der vorliegende Band der Körber-Stiftung diskutiert die vielfältigen Geschlechterrollen in Deutschland, der Türkei und unter türkischen Migrant/-innen hierzulande. Im Unterschied zu den zahlreichen Arbeiten, die sich mit der Situation türkischer Frauen auseinandersetzen, erörtert das Werk auch Konzepte von Männlichkeit.Gender relations, especially the role of women, stand in the forefront of mutual perceptions of Germans and Turks. This volume of the Koerber-Foundation discusses diverse gender roles in Germany, Turkey and among male and female Turkish migrants in Germany. In contrast to the numerous studies that deal with the situation of Turkish women, this book also examines concepts of masculinity.

  7. Solar short-distance heat. State of projects in Germany; Solare Nahwaerme. Stand der Projekte in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, M.N. [Technische Univ. Braunschweig (Germany). Inst. fuer Gebaeude- und Solartechnik, Inter-Governmental Maritime Consultative Organization, Steinbeis Transferzentrum Energie-, Gebaeude- und Solartechnik (STZ-EGS), Stuttgart (Germany)

    1999-10-01

    After the successful testing of smaller solar-assisted short-distance heat projects during the first half of the 90s in Germany (e.g., Ravensburg, Koengen, Neckarsulm, Schwaebisch-Gmuend), the first large-scale solar plants with long-term thermal energy stores went operational in Hamburg and Friedrichshafen in late 1996. So, a goal was attained that had seemed Utopian for many years: to heat buildings in winter with solar energy stored during summer. (orig.) [Deutsch] Nach der erfolgreichen Erprobung von kleineren solarunterstuetzten Nahwaermeprojekten in der ersten Haelfte der neunziger Jahre in Deutschland (z.B. Ravensburg, Koengen, Neckarsulm, Schwaebisch-Gmuend) gingen Ende 1996 in Hamburg und Friedrichshafen die ersten solaren Grossanlagen mit Langzeit-Waermespeicher in Betrieb. Damit wurde ein Ziel erreicht, das ueber viele Jahre hinweg utopisch erschienen war - mit der Sonnenenergie aus dem Sommer im Winter die Gebaeude zu beheizen. (orig.)

  8. Renewable energies in Germany. Data on the development in 2016; Erneuerbare Energien in Deutschland. Daten zur Entwicklung im Jahr 2016

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-03-15

    The Working Group on Renewable Energy Statistics (AGEE-Stat), which regularly evaluates the use of renewable energies on behalf of the German Federal Ministry of Economics and Energy, has made an initial assessment of the development of renewable energies in Germany on the basis of available, mostly provisional data of 2016. The present background paper describes the previous findings for the areas of electricity, heat and transport, supplemented by figures on economic significance as well as on emission reductions through renewable energies. [German] Die Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat), die im Auftrag des Bundesministeriums fuer Wirtschaft und Energie regelmaessig die Nutzung der erneuerbaren Energien bilanziert, hat auf der Grundlage verfuegbarer, zumeist vorlaeufiger Daten eine erste Abschaetzung zur Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2016 erstellt. Das vorliegende Hintergrundpapier beschreibt die bisherigen Erkenntnisse fuer die Bereiche Strom, Waerme und Verkehr, ergaenzt um Zahlen zur wirtschaftlichen Bedeutung sowie zur Emissionsvermeidung durch erneuerbare Energien.

  9. Discovery of the benchmark metal poor T8 dwarf BD+01 2920B

    CERN Document Server

    Pinfield, D J; Lodieu, N; Leggett, S K; Tinney, C G; van Spaandonk, L; Marocco, F; Smart, R; Gomes, J; Smith, L; Lucas, P W; Day-Jones, A C; Murray, D N; Katsiyannis, A C; Catalan, S; Cardoso, C; Clarke, J R A; Folkes, S; Galvez-Ortiz, M C; Homeier, D; Jenkins, J S; Jones, H R A; Zhang, Z H

    2012-01-01

    We have searched the WISE first data release for widely separated (<10,000AU) late T dwarf companions to Hipparcos and Gliese stars. We have discovered a new binary system containing a K-band suppressed T8p dwarf WISEP J1423+0116 and the mildly metal poor ([Fe/H]=-0.38+-0.06) primary BD+01 2920 (Hip 70319), a G1 dwarf at a distance of 17.2pc. This new benchmark has Teff=680+-55K and a mass of 20-50 Mjup. Its spectral properties are well modelled except for known discrepancies in the Y and K bands. Based on the well determined metallicity of its companion, the properties of BD+01 2920B imply that the currently known T dwarfs are dominated by young low-mass objects. We also present an accurate proper motion for the T8.5 dwarf WISEP J075003.84+272544.8.

  10. Indirect Violation of CP, T and CPT in the Bd-system

    CERN Document Server

    Bañuls, M C

    2001-01-01

    The problem of indirect violation of discrete symmeties CP, T and CPT in a neutral meson system can be described using two complex parameters epsilon and delta, which are invariant under rephasing of meson and quark fields. For the Bd system, where the width difference between the physical states is negligible, only Re(delta) and Im(epsilon) survive. As a consequence, the traditional observables constructed for kaons, which are based on flavour tag, are not useful for the analogous study in this system. We describe how using a CP tag and studying CP-to-flavour transitions of the B mesons, we may build asymmetries, alternative to those used for the kaon, which enable us to test T and CPT invariances of the effective hamiltonian for the Bd system.

  11. The active source in the region of the Herbig star BD+40 4124.

    Science.gov (United States)

    Palla, F.; Testi, L.; Hunter, T. R.; Taylor, G. B.; Prusti, T.; Felli, M.; Natta, A.; Stanga, R. M.

    1995-01-01

    We present new near-infrared, millimeter and radio observations of the region associated with BD+40 4124, a Herbig Be star located in the direction of the Cygnus arm. BD+40 4124 is the optically brightest member of a small group of young emission line stars, including V 1318 Cygni and V 1686 Cygni. Near-IR broad-band imaging of V 1318 Cygni reveals the presence of two distinct stellar components oriented north-south, a result recently reported by Aspin et al. (1994). On a larger scale, the near-IR images also indicate the presence of many highly embedded sources concentrated in the vicinity of the bright visible stars. In the central part of the cluster, the near-IR sources outnumber the optically visible ones by a factor of three. The distribution of the high density molecular gas traced by the CS J=5->4 emission is highly concentrated around V1318 and V1686 Cygni, while the total column density of gas traced by the C^18^O J=2->1 shows a ridge morphology centered on these sources. The Herbig star BD+40 4124lies at the edge of both structures. From the otpically thin C^18^O emission, we derive a total molecular mass of M_core_=280Msun_. A molecular outflow has been detected in CO J=2->1. The high velocity gas is confined to a compact region of size =~20", corresponding to a physical length of 0.1pc. The outflow is not well resolved, or collimated, on the observed scales. We have also detected H_2_O maser emission at 22.2GHz at a position coincident with the center of the bipolar outflow. Both the maser and the outflow are located at the position of the southern source V1318 S which we identify as the source responsible for the activity observed in the BD+40 region.

  12. Transformation of Acinetobacter sp. strain BD413 by transgenic sugar beet DNA.

    Science.gov (United States)

    Gebhard, F; Smalla, K

    1998-04-01

    The ability of Acinetobacter sp. strain BD413(pFG4 delta nptII) to take up and integrate transgenic plant DNA based on homologous recombination was studied under optimized laboratory conditions. Restoration of nptII, resulting in kanamycin-resistant transformants, was observed with plasmid DNA, plant DNA, and homogenates carrying the gene nptII. Molecular analysis showed that some transformants not only restored the 317-bp deletion but also obtained additional DNA.

  13. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 2: flame-retardant finishings of selected products - applications-focused analysis: state of the art, trends, alternatives; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 2: Flammhemmende Ausruestung ausgewaehlter Produkte - anwendungsbezogene Betrachtung: Stand der Technik, Trend, Alternativen

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Schwarz, W.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  14. 75 FR 61343 - Airworthiness Directives; Rolls-Royce Deutschland Ltd & Co KG (RRD) Models Tay 620-15, Tay 650-15...

    Science.gov (United States)

    2010-10-05

    ... Deutschland Ltd & Co KG (RRD) Models Tay 620-15, Tay 650-15, and Tay 651-54 Turbofan Engines AGENCY: Federal... operational data of the Tay 651-54 engine, it has been found that the actual stress levels in the Tay 651-54... Tay 651-54 engine, it has been found that the actual stress levels in the Tay 651-54 engine High...

  15. »Meine Tochter […] soll alles lernen, was die weissen Mädchen lernen…«. »Schwarze« Perspektiven auf Deutschland um 1900

    Directory of Open Access Journals (Sweden)

    Josch Lampe

    2015-11-01

    Full Text Available Der Artikel untersucht zwei gegensätzliche »schwarze« Perspektiven auf Deutschland um 1900. Ein Vergleich zwischen dem aus dem ehemaligen Deutsch-Südwestafrika stammenden Friedrich Maharero und dem Togolesen Nayo Bruce zeigt, inwiefern zwei unterschiedliche Standpunkte im kolonialen Kontext nicht nur die Umkehrperspektiven kolonialer Strukturen verdeutlichen, sondern in ihrer Verschiedenheit auch die Komplexität der Thematik darlegen.

  16. "Kein Zeugnis abzulegen, wäre Verrat": Holocaustausstellungen an Stätten des Gedenkens im internationalen Vergleich – Deutschland, Frankreich, Großbritannien und Israel

    OpenAIRE

    Hofer-Englmaier, Iris Pamela Anna

    2015-01-01

    Die Studie zielt auf eine vergleichende Analyse der ausstellerischen Diskurse von Stätten des Gedenkens an den Holocaust in den Ländern Großbritannien, Frankreich, Israel und Deutschland. Hierbei wird der Begriff des Holocaust so weit gefasst, wie es im englischsprachigen Diskurs üblich ist. Er beinhaltet neben den Juden auch andere Bevölkerungsgruppen, die von den Nationalsozialisten verfolgt wurden. Untersucht werden konkret das Imperial War Museum, London's Museum of Jewish Life und d...

  17. A NLTE analysis of the hot subdwarf O star Bd+28 4211. I. The UV spectrum

    CERN Document Server

    Latour, M; Chayer, P; Brassard, P

    2013-01-01

    We present a detailed analysis of the UV spectrum of the calibration star Bd+28 4211 using high-quality spectra obtained with the HST and FUSE satellites. To this aim, we compare quantitatively the observed data with model spectra obtained from state-of-the-art NLTE metal line-blanketed model atmospheres and synthetic spectra calculated with TLUSTY and SYNSPEC. We thus determine in a self-consistent way the abundances of eleven elements with well-defined lines in the UV, namely those of C, N, O, F, Mg, Si, P, S, Ar, Fe, and Ni. The derived abundances range from about solar to 1/10 solar. We find that the overall quality of the derived spectral fits is very satisfying. Our spectral analysis can be used to constrain rather tigthly the effective temperature of Bd+28 to a value of teff = 82,000 +/- 5000 K. We also estimate conservatively that its surface gravity falls in the range log g = 6.2 -0.1/+0.3. Assuming that the Hipparcos measurement for Bd+28 is fully reliable and that our model atmospheres are reasonab...

  18. Mixing and CP violation in the Bd and Bs systems at ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00229256; The ATLAS collaboration

    2016-01-01

    This note includes a measurement of the $B^0_s$ decay parameters in the $ B_s \\rightarrow J/\\psi$ channel and a measurement of the $B_d$ meson using the statistics collected by the ATLAS experiment in Run I of the LHC. The first result presents the measurement of the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the width difference between the mass eigenstates $\\Delta \\Gamma_s$. The second result presents the measurement of the width difference $\\Delta \\Gamma_d$, which is extracted from the measurement of the lifetime dependence of $B_d \\to J/\\psi K_S$ and $B_d \\to J/\\psi K^{*0}$ decays. The obtained results are $\\phi_s = −0.098 \\pm 0.084 (\\textrm{stat.}) \\pm 0.040 (\\textrm{syst.})$ rad. and $\\Delta \\Gamma_d / \\Gamma_d = (-0.1 \\pm 1.1 (\\textrm{stat.}) \\pm 0.9 (\\textrm{syst.}))\\times 10^{-2}$.

  19. Identification and characterization of the RouenBd1987 Babesia divergens Rhopty-Associated Protein 1.

    Directory of Open Access Journals (Sweden)

    Marilis Rodriguez

    Full Text Available Human babesiosis is caused by one of several babesial species transmitted by ixodid ticks that have distinct geographical distributions based on the presence of competent animal hosts. The pathology of babesiosis, like malaria, is a consequence of the parasitaemia which develops through the cyclical replication of Babesia parasites in a patient's red blood cells, though symptoms typically are nonspecific. We have identified the gene encoding Rhoptry-Associated Protein -1 (RAP-1 from a human isolate of B. divergens, Rouen1987 and characterized its protein product at the molecular and cellular level. Consistent with other Babesia RAP-1 homologues, BdRAP-1 is expressed as a 46 kDa protein in the parasite rhoptries, suggesting a possible role in red cell invasion. Native BdRAP-1 binds to an unidentified red cell receptor(s that appears to be non-sialylated and non-proteinacious in nature, but we do not find significant reduction in growth with anti-rRAP1 antibodies in vitro, highlighting the possibility the B. divergens is able to use alternative pathways for invasion, or there is an alternative, complementary, role for BdRAP-1 during the invasion process. As it is the parasite's ability to recognize and then invade host cells which is central to clinical disease, characterising and understanding the role of Babesia-derived proteins involved in these steps are of great interest for the development of an effective prophylaxis.

  20. Chemical Analysis of the Ninth Magnitude Carbon-Enhanced Metal-Poor Star BD+44 493

    CERN Document Server

    Ito, H; Beers, T C; Tominaga, N; Honda, S

    2013-01-01

    We present detailed chemical abundances for the bright carbon-enhanced metal-poor (CEMP) star BD+44 493, previously reported on by Ito et al. Our measurements confirm that BD+44 493 is an extremely metal-poor ([Fe/H]=-3.8) subgiant star with excesses of carbon and oxygen. No significant excesses are found for nitrogen and neutron-capture elements (the latter of which place it in the CEMP-no class of stars). Other elements that we measure exhibit abundance patterns that are typical for non-CEMP extremely metal-poor stars. No evidence for variations of radial velocity have been found for this star. These results strongly suggest that the carbon enhancement in BD+44 493 is unlikely to have been produced by a companion asymptotic giant-branch star and transferred to the presently observed star, nor by pollution of its natal molecular cloud by rapidly-rotating, massive, mega metal-poor ([Fe/H] < -6.0) stars. A more likely possibility is that this star formed from gas polluted by the elements produced in a "fain...

  1. The mysterious sdO X-ray binary BD+37 442

    CERN Document Server

    Heber, U; Irrgang, A; Schneider, D; Barbu-Barna, I; Mereghetti, S; La Palombara, N

    2014-01-01

    Pulsed X-ray emission in the luminous, helium-rich sdO BD+37 442 has recently been discovered (La Palombara et al., 2012). It was suggested that the sdO star has a neutron star or white dwarf companion with a spin period of 19.2 s. After HD 49798, which has a massive white dwarf companion spinning at 13.2 s in an 1.55 day orbit, this is only the second O-type subdwarf from which X-ray emission has been detected. We report preliminary results of our ongoing campaign to obtain time-resolved high-resolution spectroscopy using the CAFE instrument at Calar Alto observatory and SARG at the Telescopio Nationale Galileo. Atmospheric parameters were derived via a quantitative NLTE spectral analysis. The line fits hint at an unusually large projected rotation velocity. Therefore it seemed likely that BD+37 442 is a binary similar to HD 49798 and that the orbital period is also similar. The level of X-ray emission from BD+37 442 could be explained by accretion from the sdO wind by a neutron star orbiting at a period of ...

  2. Low-Cost BD/MEMS Tightly-Coupled Pedestrian Navigation Algorithm

    Directory of Open Access Journals (Sweden)

    Tianyu Lin

    2016-05-01

    Full Text Available Pedestrian Dead Reckoning (PDR by combining the Inertial Measurement Unit (IMU and magnetometer is an independent navigation approach based on multiple sensors. Since the inertial component error is significantly determined by the parameters of navigation equations, the navigation precision may deteriorate with time, which is inappropriate for long-time navigation. Although the BeiDou (BD navigation system can provide high navigation precision in most scenarios, the signal from satellites is easily degraded because of buildings or thick foliage. To solve this problem, a tightly-coupled BD/MEMS (Micro-Electro-Mechanical Systems integration algorithm is proposed in this paper, and a prototype was built for implementing the integrated system. The extensive experiments prove that the BD/MEMS system performs well in different environments, such as an open sky environment and a playground surrounded by trees and thick foliage. The proposed algorithm is able to provide continuous and reliable positioning service for pedestrian outdoors and thereby has wide practical application.

  3. Career mobility dynamics : a comparative analysis of the United States, Norway, and West Germany

    OpenAIRE

    Allmendinger, Jutta

    1989-01-01

    "Die vorliegende Studie untersucht und vergleicht Determinanten von Karriereverläufen in drei Nationen: den Vereinigten Staaten, Norwegen und der Bundesrepublik Deutschland. Die empirischen Analysen basieren auf retrospektiven Lebensverlaufsdaten deutscher, amerikanischer und norwegischer Männer, die 1930 geboren wurden und deren beruflicher Werdegang bis zum Alter von 40 Jahren nachgezeichnet wurde. Die Untersuchungen addressieren Themengebiete der Statuserwerbsforschung im Lebensverlauf und...

  4. Eine neue Deroceras-Art (Gastropoda, Pulmonata, Agriolimacidae) von der Griechischen Insel Samos

    NARCIS (Netherlands)

    Rähle, W.

    1983-01-01

    Im Frühjahr 1982 sammelte Herr Jens Hemmen aus Wiesbaden (Bundesrepublik Deutschland) auf der Insel Samos zahlreiche Individuen einer noch unbekannten Deroceras-Art, die ihren anatomischen Merkmalen nach zur Untergattung Plathystimulus Wiktor, 1973 gehört. Die Tiere waren fast alle erwachsen und erm

  5. Romanistik ohne Latein? Zu einer Empfehlung der Konferenz der Romanischen Seminare (Romance Studies without Latin? On a Recommendation from the Conference of Romance Seminars)

    Science.gov (United States)

    Neumeister, Sebastian

    1973-01-01

    Reaction to a February 19, 1972 recommendation of the Konferenz der Romanischen Seminare der Bundesrepublik Deutschland und West-Berlins in Deutschen Romanistenverband'' (Conference of Romance Seminars of the Federal Republic of Germany and West Berlin of the German Association of Romance Philologists) to discontinue the Latin prerequisite for…

  6. Down-regulation of BdBRI1, a putative brassinosteroid receptor gene produces a dwarf phenotype with enhanced drought tolerance in Brachypodium distachyon.

    Science.gov (United States)

    Feng, Ying; Yin, Yanhai; Fei, Shuizhang

    2015-05-01

    Brassinosteroids (BRs) play important roles in plant growth, development and responses to a range of environmental cues. Although the mechanism of how BRs regulate growth and development is well-understood in Arabidopsis, the effect of BRs on stress tolerance, particularly drought tolerance remains unknown. We isolated a BRI1 (BRASSINOSTEROID INSENSITIVE 1) homologous gene, BdBRI1 from Brachypodium distachyon, a model for temperate grasses and cereals, created and characterized RNA interference (RNAi) knockdown mutants for BdBRI1 in Brachypodium. The loss-of-function BdBRI1-RNAi mutants exhibited reduced plant height, shortened internodes, narrow and short leaf, and reduced expression of BR signaling genes, BdBES1, BdBZR1, BdBLE2, and enhanced expression of BR biosynthesis genes BdD2, BdCPD and BdDWF4. More importantly, BdBRI1 RNAi mutants exhibited enhanced drought tolerance, accompanied by highly elevated expression of drought-responsive genes, BdP5CS, BdCOR47/BdRD17, together with BdERD1 and BdRD26, two putative targets of the transcription factors BES1 and BZR1 that are key components of the BR signaling pathway. Our results suggest that BR signaling and biosynthesis are largely conserved among Arabidopsis, rice and Brachypodium, and that BR signaling plays an important role in drought tolerance by directly regulating expression of key drought-responsive genes. The effect of BR biosynthesis or crosstalks between BR and other hormones or components of stress signaling pathways on drought tolerance is discussed.

  7. Detection of Trichomonas vaginalis DNA by use of self-obtained vaginal swabs with the BD ProbeTec Qx assay on the BD Viper system.

    Science.gov (United States)

    Van Der Pol, Barbara; Williams, James A; Taylor, Stephanie N; Cammarata, Catherine L; Rivers, Charles A; Body, Barbara A; Nye, Melinda; Fuller, Deanna; Schwebke, Jane R; Barnes, Mathilda; Gaydos, Charlotte A

    2014-03-01

    Trichomonas vaginalis is the most prevalent nonviral sexually transmitted infection worldwide, and improved diagnostic methods are critical for controlling this pathogen. Diagnostic assays that can be used in conjunction with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most impact on disease control. Here we describe the performance of the new BD T. vaginalis Qx (TVQ) amplified DNA assay, which can be performed on the automated BD Viper system. We focus on data from vaginal swab samples, since this is the specimen type routinely used for traditional trichomonas testing and the recommended specimen type for chlamydia/gonorrhea screening. Vaginal swabs were obtained from women attending sexually transmitted disease or family planning clinics at 7 sites. Patient-collected vaginal swabs were tested by the TVQ assay, and the Aptima T. vaginalis (ATV) assay was performed using clinician-collected vaginal swabs. Additional clinician-collected vaginal swabs were used for the wet mount and culture methods. Analyses included comparisons versus the patient infection status (PIS) defined by positive results with the wet mount method or culture, direct comparisons assessed with κ scores, and latent class analysis (LCA) as an unbiased estimator of test accuracy. Data from 838 women, 116 of whom were infected with T. vaginalis, were analyzed. The TVQ assay sensitivity and specificity estimates based on the PIS were 98.3% and 99.0%, respectively. The TVQ assay was similar to the ATV assay (κ=0.938) in direct analysis. LCA estimated the TVQ sensitivity and specificity as 98.3 and 99.6%, respectively. The TVQ assay performed well using self-collected vaginal swabs, the optimal sample type, as recommended by the CDC for chlamydia/gonorrhea screening among women.

  8. The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity.

    Directory of Open Access Journals (Sweden)

    Marco Ventura

    2009-12-01

    Full Text Available Bifidobacteria, one of the relatively dominant components of the human intestinal microbiota, are considered one of the key groups of beneficial intestinal bacteria (probiotic bacteria. However, in addition to health-promoting taxa, the genus Bifidobacterium also includes Bifidobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. The genome of B. dentium Bd1, a strain isolated from dental caries, was sequenced to completion to uncover a single circular 2,636,368 base pair chromosome with 2,143 predicted open reading frames. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialized nutrient acquisition, defences against antimicrobials, and gene products that increase fitness and competitiveness within the oral niche. B. dentium Bd1 was shown to metabolize a wide variety of carbohydrates, consistent with genome-based predictions, while colonization and persistence factors implicated in tissue adhesion, acid tolerance, and the metabolism of human saliva-derived compounds were also identified. Global transcriptome analysis demonstrated that many of the genes encoding these predicted traits are highly expressed under relevant physiological conditions. This is the first report to identify, through various genomic approaches, specific genetic adaptations of a Bifidobacterium taxon, Bifidobacterium dentium Bd1, to a lifestyle as a cariogenic microorganism in the oral cavity. In silico analysis and comparative genomic hybridization experiments clearly reveal a high level of genome conservation among various B. dentium strains. The data indicate that the genome of this opportunistic cariogen has evolved through a very limited number of horizontal gene acquisition events, highlighting the narrow boundaries that separate commensals from

  9. Use of the BD-100R as a neutron spectrometer through applied pressure variation

    Energy Technology Data Exchange (ETDEWEB)

    White, B.; Ebert, D.; Munno, F. (Univ. of Maryland, College Park (USA))

    1991-05-01

    A study was undertaken to demonstrate the feasibility of using the well-characterized BD-100R neutron bubble dosimeter as a neutron spectrometer in low-level radiation fields. The BD-100R dosimeters used in this work consisted of a test tube containing an elastic polymer with interspersed droplets of two types of Freon: Freon-12 and Freon-114. Each superheated liquid droplet is a potential nucleation site, with the minimum energy needed to form a bubble at the nucleation site being inversely proportional to the square of the difference between the applied and the vapor pressure (i.e., Emin alpha(delta P)-2). For a given dose, the number of bubbles formed continually decreases with increasing applied pressure, until a pressure is reached where no bubbles are formed, since the energy transferred can no longer vaporize the Freon. This investigation is intended to demonstrate the feasibility of measuring an unknown spectrum utilizing the dosimeter response (number of bubbles formed) as a function of the neutron energy (applied pressure). A set of 12 dosimeters was exposed under various applied pressures in a well-characterized neutron energy spectrum at the East Beam Port (EBP) of the Maryland University Training Reactor (MUTR). The dosimeters were placed inside a pressure chamber that could accommodate up to 18 dosimeters. Energy response coefficients (cross-sections) were obtained by spectral unfolding techniques on the known spectrum. The same set of dosimeters were then irradiated using a paraffin-moderated Pu/Be source. Measured spectral estimates obtained using the response coefficients were compared with numerical computations generated using the ANISN computer code. The results indicate that further research using the BD-100R as a neutron spectrometer in low radiation fields is warranted.

  10. Comparison of Allergenicity at Gly m 4 and Gly m Bd 30K of Soybean after Genetic Modification.

    Science.gov (United States)

    Tsai, Jaw-Ji; Chang, Ching-Yun; Liao, En-Chih

    2017-02-15

    Despite rapid growth of genetically modified (GM) crops, effective evaluations of genetic modification on allergenicity are still lacking. Gly m Bd 30K is cross-reactive with cow's milk protein casein, Gly m 4, and with birch pollen allergen Bet v 1. Here we compared the allergenicity between GM and non-GM soybeans with respect to the foci Gly m 4 and Gly m Bd 30K. Recombinant allergens of Gly m Bd 30K and Gly m 4 were generated and polyclonal antibodies raised to identify these two allergenic components in soybeans. GM soybean was first PCR-confirmed using 35S promoter. A total of 20 soybeans (half GM, half non-GM) obtained from a food market were used to assess their allergenicity based on IgE-binding and histamine release. The concentrations of Gly m Bd 30K and Gly m 4 in soybeans were then determined. Most soybean-allergic patients (9 of 10) showed IgE-positive reactions to the allergen of 30 kDa in molecular weight. That allergen turned out to be Glycine max Gly m Bd 30K based on LC-MS/MS analyses. Gly m Bd 30K is therefore the major allergen in the soybean. An increase in the transcription of both the Gly m 4 (stress-induced protein SAM22) and Gly m Bd 28K (soybean allergen precursor) was found after genetic modification. The protein concentrations of Gly m 4 and Gly m Bd 30K were not statistically significant different between non-GM and GM soybeans. There were also no statistical significances between them in the tests of IgE binding and histamine release. In conclusion, soybeans showed similar concentrations of Gly m Bd 30K and Gly m 4 regardless of genetic modification or absence thereof. The allergenicity of both Gly m Bd 30K and Gly m 4 was therefore not altered after genetic modification. Patients showing hypersensitivity to soybeans and who had pre-existing allergy to birch pollen and cow's milk casein might not further increase their allergic reactions following exposures to the GM soybeans.

  11. Jofre de Foixa, “Subrafusa ab cabirol” (BdT 304.4

    Directory of Open Access Journals (Sweden)

    Wendy Pfeffer

    2011-11-01

    Full Text Available Jofre de Foixa’s verses “Subrafusa ab cabirol” (BdT 304.4 merit attention for the light the two ‘coblas’ shed on Jofre’s familiarity with his Occitan predecessors, for the information the text provides regarding food practices in his time, and for the use of a food term rare in the Iberian peninsula, “unyo”. The resources of culinary history, specifically fourteenth- and fifteenth-century Languedocian and Catalan cookbooks, allow us better to understand the meaning of Jofre’s lyric.

  12. BD-22deg3467, a DAO-type Star Exciting the Nebula Abell 35

    Science.gov (United States)

    Ziegler, M.; Rauch, T.; Werner, K.; Koppen, J.; Kruk, J. W.

    2013-01-01

    Spectral analyses of hot, compact stars with non-local thermodynamical equilibrium (NLTE) model-atmosphere techniques allow the precise determination of photospheric parameters such as the effective temperature (T(sub eff)), the surface gravity (log g), and the chemical composition. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Aims. Previous spectral analyses of the exciting star of the nebula A35, BD-22deg3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. We aim to identify all observed lines in the ultraviolet (UV) spectrum of BD-22deg3467 and to determine the abundances of the respective species precisely. Methods. For the analysis of high-resolution and high signal-to-noise ratio (S/N) far-ultraviolet (FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. Results. The best agreement with the UV observation of BD-22deg3467 is achieved at T(sub eff) = 80 +/- 10 kK and log g = 7.2 +/- 0.3. While T(sub eff) of previous analyses is verified, log g is significantly lower. We re-analyzed lines of silicon and iron (1/100 and about solar abundances, respectively) and for the first time in this star identified argon, chromium, manganese, cobalt, and nickel and determined abundances of 12, 70, 35, 150, and 5 times solar, respectively. Our results partially agree with predictions of diffusion models for DA-type white dwarfs. A combination of photospheric and interstellar line-absorption models reproduces more than 90% of the observed absorption features. The stellar mass is M approx. 0.48 Solar Mass. Conclusions. BD.22.3467 may not have been massive enough to ascend the asymptotic giant branch and may have evolved directly from the extended horizontal branch

  13. BD30AV—HD系列数字高清延时器

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    B&M MODERN MEDIA INC.为广播级视音频用户推出的高端数字高、标清信号处理产品系列—BD30AV—HD系列高清数字延时器.兼容数字HD—SDI和SD—SDI嵌入式信号,支持各种HD/SD信号格式。可选HD—SDI信号的延时时间最长为120秒,或SD—SDI信号的延时时间最长达720秒,

  14. An evaluation of the BD-100R rechargeable neutron bubble dosimeter

    Energy Technology Data Exchange (ETDEWEB)

    Millett, M.; Munno, F.; Ebert, D.; Nelson, M. (Univ. of Maryland, College Park (USA))

    1991-03-01

    The purpose of this paper is to present data gathered in the evaluation of the BD-100R neutron bubble dosimeter done at the University of Maryland and the Naval Research Lab. The performance of 12 dosimeters has been followed over 15 exposure-recharge cycles under a wide range of exposure conditions. Included in this paper are the results from tests on dose rate dependence, neutron energy dependence, beta and gamma exposure, and recharge cycle performance. A statistical analysis of the reusability performance of the dosimeter as a function of dose equivalent is also presented.

  15. Personnel situation in medical radiation physics in Germany - results of an interview; Zur Personalsituation in der Medizinischen Strahlenphysik in Deutschland - Auswertung einer Umfrage

    Energy Technology Data Exchange (ETDEWEB)

    Leetz, H.K.; Eipper, H.H.; Gfirtner, H. [Med. Physik, Klinikum Passau (Germany); Schneider, P. [Inst. fuer Med. Physik, Klinikum Fulda (Germany); Welker, K. [Abt. Med. Physik, Krankenhaus Moabit, Berlin (Germany)

    2003-07-01

    Stichprobe wurden dann auf die Bundesrepublik hochgerechnet. Die Berechnung ergab ein Defizit von 72% fuer das Gesamtpersonal und von 58% fuer die Anzahl Physiker. Unter Beruecksichtigung der Altersverteilung der Mitglieder der DGMP errechnet sich daraus ein Bedarf an Ausbildungskapazitaet von etwa 100 Medizinphysikern im Jahr fuer die Bundesrepublik, wenn dieses Defizit im Verlauf von 10 Jahren abgebaut werden soll.

  16. Mannans and endo-β-mannanases (MAN) in Brachypodium distachyon: expression profiling and possible role of the BdMAN genes during coleorhiza-limited seed germination.

    Science.gov (United States)

    González-Calle, Virginia; Barrero-Sicilia, Cristina; Carbonero, Pilar; Iglesias-Fernández, Raquel

    2015-07-01

    Immunolocalization of mannans in the seeds of Brachypodium distachyon reveals the presence of these polysaccharides in the root embryo and in the coleorhiza in the early stages of germination (12h), decreasing thereafter to the point of being hardly detected at 27h. Concurrently, the activity of endo-β-mannanases (MANs; EC 3.2.1.78) that catalyse the hydrolysis of β-1,4 bonds in mannan polymers, increases as germination progresses. The MAN gene family is represented by six members in the Brachypodium genome, and their expression has been explored in different organs and especially in germinating seeds. Transcripts of BdMAN2, BdMAN4 and BdMAN6 accumulate in embryos, with a maximum at 24-30h, and are detected in the coleorhiza and in the root by in situ hybridization analyses, before root protrusion (germination sensu stricto). BdMAN4 is not only present in the embryo root and coleorhiza, but is abundant in the de-embryonated (endosperm) imbibed seeds, while BdMAN2 and BdMAN6 are faintly expressed in endosperm during post-germination (36-42h). BdMAN4 and BdMAN6 transcripts are detected in the aleurone layer. These data indicate that BdMAN2, BdMAN4 and BdMAN6 are important for germination sensu stricto and that BdMAN4 and BdMAN6 may also influence reserve mobilization. Whether the coleorhiza in monocots and the micropylar endosperm in eudicots have similar functions, is discussed.

  17. Albertet, “Donna pros e richa” (BdT 16.11

    Directory of Open Access Journals (Sweden)

    Francesca Sanguineti

    2009-11-01

    Full Text Available This paper will provide a commentary and a new critical edition of “Donna pros e richa” by Albertet, a poem with an exceptional metrical structure, halfway between a ‘canso’ and an isostrophic ‘descort’. Its structure is identical to Raimbaut de Vaqueiras’ “Carros” (BdT 392.32: most likely Albertet’s poem is the original while “Truan, mala guerra” is a contrafactum, considering the fact that it is comparable to a sirventes. The lyric self urgently requests the love of a Genoese lady, complaining of her indifference and cursing her quite violently at the end of each stanza. The passionate tone that characterizes the poem becomes less so towards the end where God is finally called upon to protect the lady. What is clear here is, on the one hand, the poem’s conformity with the characteristics of the ‘mala canso’, and, on the other, its similarity with another poem by Raimbaut de Vaqueiras, the ‘contrasto’ with the Genoese lady (BdT 392.7. Thus Albertet’s poem is curious from different points of view: for its metrical form, uncommon in a ‘canso’; for its linguistic register which ressembles that of narrative genres such as the ‘fabliaux’; for its rhymes which offer a series of analogies and exchanges of rhyme-words with the two Raimbauts, the previously mentioned Raimbaut de Vaqueiras and Raimbaut d’Aurenga.

  18. A NLTE analysis of the hot subdwarf O star BD+28 4211. II. The optical spectrum

    CERN Document Server

    Latour, M; Green, E M; Brassard, P

    2015-01-01

    We present the second part of our detailed analysis of the hot sdO and spectroscopic standard star BD+28 4211, in which we focus on the optical spectrum. In the first part of our study, we determined the abundances of some 11 metals detected in the atmosphere of BD+28 4211 using UV spectra of the star and corroborated the fundamental parameters estimated in past studies (Teff $\\sim$ 82,000 K, log g $\\sim$ 6.2, and solar N(He)/N(H)). In this work, we aim at rederiving these secured parameters on the sole basis of high-quality optical spectra. A first grid of non-LTE line-blanketed model atmospheres, including metals with the abundances derived from the UV spectrum, does not give satisfactory results when we apply a standard simultaneous fitting procedure to the observed H and He lines of our optical spectra. The line profiles are not finely reproduced and the resulting effective temperatures, in particular, are too low by $\\sim$10,000 K. We next investigate the probable cause of this failure, that is, the impo...

  19. Re (epsilon'/epsilon_K) vs. B_d -> phi K_S CP asymmetry

    CERN Document Server

    Ko, P; Park, J; Park, Jae-hyeon

    2005-01-01

    In a SUSY GUT seesaw scenario, the largeness of the atmospheric neutrino mixing can reflect itself into an enhanced flavor changing mixing of beauty and strange right-handed scalar quarks. If the CP violating phase in such down type squark RR insertion is the main source of CP asymmetry in B_d -> phi K_S and the gluino contributions to K0-K0 bar and B0-B0 bar mixing are negligible, there is a correlation between Re (epsilon'/epsilon_K) and B_d -> phi K_S CP asymmetry, in addition to that with the strange quark CEDM. The current data on Re (epsilon'/epsilon_K) = (16.7 +- 2.6) 10^-4 imply that S_{phi K} should be greater than \\sim 0.5 (0.25) for mu tan beta = 1 (5) TeV, assuming the RR dominance in b -> s transition and the minimal supergravity type boundary conditions for soft parameters.

  20. BD-22 3467, a DAO-type star exciting the nebula Abell 35

    CERN Document Server

    Ziegler, M; Werner, K; Koeppen, J; Kruk, J W

    2012-01-01

    Spectral analyses of hot, compact stars with NLTE (non-local thermodynamical equilibrium) model-atmosphere techniques allow the precise determination of photospheric parameters. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Previous spectral analyses of the exciting star of the nebula A 35, BD-22 3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. For the analysis of high-resolution and high-S/N (signal-to-noise) FUV (far ultraviolet, FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. The best agreement with the UV observation of BD-22 3467 is achieved at Teff = 80 +/- 10 kK and log g =7.2 +/- 0.3. While Teff of previous analyses is verified, log g is significantly lower. We re-analyzed lines ...

  1. BD +44 493: A Ninth Magnitude Messenger from the Early Universe; Carbon Enhanced and Beryllium Poor

    CERN Document Server

    Ito, Hiroko; Honda, Satoshi; Beers, Timothy C

    2009-01-01

    We present a 1D LTE chemical abundance analysis of the very bright (V=9.1) Carbon-Enhanced Metal-Poor (CEMP) star BD +44 493, based on high-resolution, high signal-to-noise spectra obtained with Subaru/HDS. The star is shown to be a subgiant with an extremely low iron abundance ([Fe/H]=-3.7), while it is rich in C ([C/Fe]=+1.3) and O ([O/Fe]=+1.6). Although astronomers have been searching for extremely metal-poor stars for decades, this is the first star found with [Fe/H]<-3.5 and an apparent magnitude V<12. Based on its low abundances of neutron-capture elements (e.g., [Ba/Fe]=-0.59), BD +44 493 is classified as a "CEMP-no" star. Its abundance pattern implies that a first-generation faint supernova is the most likely origin of its carbon excess, while scenarios related to mass loss from rapidly-rotating massive stars or mass transfer from an AGB companion star are not favored. From a high-quality spectrum in the near-UV region, we set an very low upper limit on this star's beryllium abundance (A(Be)=lo...

  2. Isolation and characterization of a buffalograss (Buchloe dactyloides) dehydration responsive element binding transcription factor, BdDREB2.

    Science.gov (United States)

    Zhang, Pan; Yang, Peizhi; Zhang, Zhiqiang; Han, Bo; Wang, Weidong; Wang, Yafang; Cao, Yuman; Hu, Tianming

    2014-02-15

    Dehydration responsive element binding (DREB) transcription factors play an important role in the regulation of stress-related genes. These factors contribute to resistance to different abiotic stresses. In the present study, a novel DREB transcription factor, BdDREB2, isolated from Buchloe dactyloides, was cloned and characterized. The BdDREB2 protein was estimated to have a molecular weight of 28.36kDa, a pI of 5.53 and a typical AP2/ERF domain. The expression of BdDREB2 was involved in responses to drought and salt stresses. Overexpression of BdDREB2 in tobacco showed higher relative water and proline content, and was associated with lower MDA content under drought stress, suggesting that the transgenic tobacco may tolerate drought stress better. Results demonstrate that BdDREB2 may play an important role in the regulation of abiotic stress responses, and mediate many physiological pathways that enhance stress tolerance in plants. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Detection of Phosphorus, Sulphur, and Zinc in the Carbon-Enhanced Metal-Poor Star BD+44 493

    CERN Document Server

    Roederer, Ian U; Beers, Timothy C

    2016-01-01

    The carbon-enhanced metal-poor star BD+44 493 ([Fe/H]=-3.9) has been proposed as a candidate second-generation star enriched by metals from a single Pop III star. We report the first detections of P and S and the second detection of Zn in any extremely metal-poor carbon-enhanced star, using new spectra of BD+44 493 collected by the Cosmic Origins Spectrograph on the Hubble Space Telescope. We derive [P/Fe]=-0.34 +/- 0.21, [S/Fe]=+0.07 +/- 0.41, and [Zn/Fe]=-0.10 +/- 0.24. We increase by ten-fold the number of Si I lines detected in BD+44 493, yielding [Si/Fe]=+0.15 +/- 0.22. The solar [S/Fe] and [Zn/Fe] ratios exclude the hypothesis that the abundance pattern in BD+44 493 results from depletion of refractory elements onto dust grains. Comparison with zero-metallicity supernova models suggests that the stellar progenitor that enriched BD+44 493 was massive and ejected much less than 0.07 Msun of Ni-56, characteristic of a faint supernova.

  4. Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo'' to inhibition by the carbon monoxide-releasing molecule, CORM-3: N-acetylcysteine reduces CO-RM uptake and inhibition of respiration.

    Science.gov (United States)

    Jesse, Helen E; Nye, Tacita L; McLean, Samantha; Green, Jeffrey; Mann, Brian E; Poole, Robert K

    2013-09-01

    CO-releasing molecules (CO-RMs) are potential therapeutic agents, able to deliver CO - a critical gasotransmitter - in biological environments. CO-RMs are also effective antimicrobial agents; although the mechanisms of action are poorly defined, haem-containing terminal oxidases are primary targets. Nevertheless, it is clear from several studies that the effects of CO-RMs on biological systems are frequently not adequately explained by the release of CO: CO-RMs are generally more potent inhibitors than is CO gas and other effects of the molecules are evident. Because sensitivity to CO-RMs cannot be predicted by sensitivity to CO gas, we assess the differential susceptibilities of strains, each expressing only one of the three terminal oxidases of E. coli - cytochrome bd-I, cytochrome bd-II and cytochrome bo', to inhibition by CORM-3. We present the first sensitive measurement of the oxygen affinity of cytochrome bd-II (Km 0.24μM) employing globin deoxygenation. Finally, we investigate the way(s) in which thiol compounds abolish the inhibitory effects of CORM-2 and CORM-3 on respiration, growth and viability, a phenomenon that is well documented, but poorly understood. We show that a strain expressing cytochrome bd-I as the sole oxidase is least susceptible to inhibition by CORM-3 in its growth and respiration of both intact cells and membranes. Growth studies show that cytochrome bd-II has similar CORM-3 sensitivity to cytochrome bo'. Cytochromes bo' and bd-II also have considerably lower affinities for oxygen than bd-I. We show that the ability of N-acetylcysteine to abrogate the toxic effects of CO-RMs is not attributable to its antioxidant effects, or prevention of CO targeting to the oxidases, but may be largely due to the inhibition of CO-RM uptake by bacterial cells. A strain expressing cytochrome bd-I as the sole terminal oxidase is least susceptible to inhibition by CORM-3. N-acetylcysteine is a potent inhibitor of CO-RM uptake by E. coli. Rational design

  5. Recombination and Fusion Expression of Porcine Defensin Gene pBD-2 in E.Coli%猪防御素基因pBD-2在大肠杆菌中的重组和融合表达

    Institute of Scientific and Technical Information of China (English)

    徐海涛; 马立保; 何启盖; 廖冰麟; 任芬芬

    2011-01-01

    哺乳动物防御素是动物机体在抵御病原微生物的防御反应中产生的一类重要的抗菌肽物质,具有十分广泛的抗菌谱,在先天免疫上起重要作用.本研究根据已报道的pBD-2基因cDNA序列,合成了3条基因片段(1、2、3).片段1、2和片段2、3各有15个碱基互补配对,PCR扩增延伸得到pBD-2基因,将pBD-2基因克隆至原核表达载体pGEX-KG,成功地在大肠杆菌BL21(DE3)中表达出pBD-2融合蛋白.pBD-2基因的成功表达为进一步研究其抗菌活性打下了基础.%Defensin is an important antimicrobial peptide produced in the course of animals' defense against pathogens,which has a broad antibacterial spectrum and plays an important role in innate immunity. Based on cDNA sequence of porcine defensin βdefensin 2 gene reported in this study, three gene fragment (1,2,3) were synthesized in this experiment. Fragment 1,2 and fragment 2,3 had respectively 15 bases for complementary pair. pBD-2 gene was produced by PCR amplifing, and pBD-2 was inserted into expression vector (pGEX-KG) and recombinant vector transformed into E.coli, where recombinant vector produced fusion protein successfully. The expression of pBD-2 gene lays a foundation in research on antimicrobial activities of defensin.

  6. Epidemiology of allergic diseases in German children; Epidemiologie allergischer Erkrankungen bei Kindern. Zeitliche Trends in Deutschland und Diskussion moeglicher Ursachen eines Trends

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, U. [Technische Univ. Muenchen (Germany). Klinische Kooperationsgruppe Umweltdermatologie GSF; Duesseldorf Univ. (Germany). Medizinisches Inst. fuer Umwelthygiene; Moellemann, A. [Duesseldorf Univ. (Germany). Medizinisches Inst. fuer Umwelthygiene; Behrendt, H. [Technische Univ. Muenchen (Germany). Klinische Kooperationsgruppe Umweltdermatologie GSF

    2001-07-01

    For many countries in Europe it was shown that allergies increased in the last decades. Data from Germany are not sufficient. Therefore results from studies in six years old children from West Germany are given which demonstrate an increase of allergies between 1985 and 1995. Possible causes are discussed. (orig.) [German] Fuer viele Laender Europas ist belegt, dass Allergien in den letzten Jahrzehnten zugenommen haben. Die Datenlage in Deutschland ist nicht ausreichend. Es werden daher die Ergebnisse von Studien an sechsjaehrigen Kindern aus Westdeutschland vorgelegt, die eine Zunahme von Allergien fuer den Zeitraum von 1985 bis 1995 nahe legen. Moegliche Ursachen werden diskutiert. (orig.)

  7. OSAKA Trial: A Randomized, Controlled Trial Comparing Tacrolimus QD and BD in Kidney Transplantation

    Science.gov (United States)

    Albano, Laetitia; Banas, Bernhard; Klempnauer, Juergen L.; Glyda, Maciej; Viklicky, Ondrej; Kamar, Nassim

    2013-01-01

    Background The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. Methods This open-label, parallel-group study randomized adults with end-stage renal disease undergoing primary kidney transplantation or retransplantation to an initial dose of tacrolimus BD 0.2 mg/kg per day (Arm 1; n=309), QD 0.2 mg/kg per day (Arm 2; n=302), QD 0.3 mg/kg per day (Arm 3; n=304) all with mycophenolate mofetil and corticosteroids (tapered) over 24 weeks, or tacrolimus QD 0.2 mg/kg per day with mycophenolate mofetil, basiliximab, and corticosteroids given only perioperatively (Arm 4; n=283). The primary composite endpoint (efficacy failure; per protocol set) was defined as graft loss, biopsy-confirmed acute rejection, or graft dysfunction at week 24. Graft dysfunction was defined as estimated glomerular filtration rate Modification of Diet in Renal Disease-4 formula of less than 40 mL/min/1.73 m2. The prespecified noninferiority margin was 12.5%. Results The per protocol set included 976 patients: 237, 263, 246, and 230 patients in Arms 1 to 4, respectively. Noninferiority of the composite endpoint was demonstrated for Arm 2 versus Arm 1; Kaplan–Meier estimates of efficacy failure were 42.2% and 40.6%, respectively (difference, −1.6%; 95% confidence interval [CI], −12.2% to 9.0%). Noninferiority to Arm 1 was not confirmed for Arm 3 (difference, −3.5%; 95% CI, −13.6% to 6.6%) or Arm 4 (difference, −7.1%; 95% CI, −16.1% to 1.9%). Graft dysfunction (estimated glomerular filtration rate <40 mL/min/1.73 m2) was the main determinant of composite-endpoint efficacy failure across all arms. Conclusions In patients representative of the European kidney transplant population, tacrolimus QD-based immunosuppression (0.2 mg/kg/day), without induction, showed similar efficacy to 0.2 mg/kg per day tacrolimus BD

  8. Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.

    Science.gov (United States)

    Roh, Dae-Hyun; Yoon, Seo-Yeon

    2014-01-01

    Sigma-1 receptors (Sig-1Rs) play a role in different types of pain and in central sensitization mechanism in spinal cord. However, it is currently unexplored whether Sig-1Rs are involved in orofacial pain processing. Here we show whether a selective Sig-1R antagonist, BD1047 reduces nociceptive responses in the mouse orofacial formalin model and the number of Fos-immunoreactive (ir) cells in the trigeminal nucleus caudalis (TNC). In addition, it was examined whether the phosphorylation of extracellular signal-regulated kinase (pERK) or p38 (pp38) mitogen-activated protein kinases (MAPK), which are closely linked to pain signaling and sensitization, in TNC was modified by BD1047. The 5% formalin (10 µL) was subcutaneously injected into the right upper lip, and the rubbing responses with ipsilateral fore- or hind paw were counted for 45 min. BD1047 (1, 3 or 10 mg/kg) were intraperitoneally treated 30 min before formalin injection. High dose of BD1047 (10 mg/kg) produced significant anti-nociceptive effects in the first and the second phase. The number of Fos-ir cells in ipsilateral side of TNC was also reduced by BD1047 as compared to that in saline-treated animals. In addition, the number of pp38-ir cells in ipsilateral TNC was decreased in BD1047-treated animals, whereas the number of pERK-ir cells was not modified. Collectively, these results demonstrate that Sig-1Rs play a pivotal role in the orofacial pain processing, and the pp38 signaling pathway can be associated with Sig-1R's action in TNC.

  9. Properties of the B+-H2 and B+-D2 complexes: A theoretical and spectroscopic study

    Science.gov (United States)

    Poad, B. L. J.; Dryza, V.; Buchachenko, A. A.; Kłos, J.; Bieske, E. J.

    2012-09-01

    The rotationally resolved infrared spectrum of the B+-D2 ion-neutral complex is recorded in the D-D stretch vibration region (2805-2875 cm-1) by detecting B+ photofragments. Analysis of the spectrum confirms a T-shaped equilibrium geometry for the B+-D2 complex with a vibrationally averaged intermolecular bond length of 2.247 Å, around 0.02 Å shorter than for the previously characterised B+-H2 complex [V. Dryza, B. L. J. Poad, and E. J. Bieske, J. Am. Chem. Soc. 130, 12986 (2008), 10.1021/ja8018302]. The D-D stretch band centre occurs at 2839.76 ± 0.10 cm-1, representing a -153.8 cm-1 shift from the Q1(0) transition of the free D2 molecule. A new three dimensional ab initio potential energy surface for the B++H2 interaction is calculated using the coupled cluster RCCSD(T) method and is used in variational calculations for the rovibrational energies of B+-H2 and B+-D2. The calculations predict dissociation energies of 1254 cm-1 for B+-H2 with respect to the B++H2 (j = 0) limit, and 1313 cm-1 for B+-D2 with respect to the B++D2 (j = 0) limit. The theoretical approach reproduces the rotational and centrifugal constants of the B+-H2 and B+-D2 complexes to within 3%, and the magnitude of the contraction of the intermolecular bond accompanying excitation of the H2 or D2 sub-unit, but underestimates the H-H and D-D vibrational band shifts by 7%-8%. Combining the theoretical and experimental results allows a new, more accurate estimation for the B+-H2 band origin (3939.64 ± 0.10 cm-1).

  10. Search for Bs --> mu+mu- and Bd --> mu+mu- Decays with 2fb-1 of ppbar Collisions

    CERN Document Server

    Aaltonen, T; Akimoto, T; Albrow, M G; Alvarez-Gonzalez, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P H; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrerar, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillol, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerritop, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenarr, C; Cuevaso, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdeckerd, G; De Lorenzo, G; Dell'Orso, Mauro; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; García, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopoloua, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokarisa, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gómez, G; Gómez-Ceballos, G; Goncharov, M; Gonzlez, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraesda Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hillc, C S; Hirschbuehl, D; Höcker, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Le Compte, T; Lee, J; Lee, J; Lee, Y J; Leeq, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Mäki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakisa, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, M; Martinj, V; Martínez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNultyi, R; Mehta, A; Mehtälä, P; Menzemerk, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsenf, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohosh, F; Punzi, G; Pursley, J; Rademackerc, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Salt, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, S Z; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojiman, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffarde, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thomg, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Vazquezl, F; Velev, G; Vellidisa, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouevq, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whitesone, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittichg, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yangm, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhengb, Y; Zucchelli, S

    2007-01-01

    We have performed a search for Bs-->mu+mu- and Bd-->mu+mu- decays in ppbar collisions at sqrt(s) = 1.96TeV using 2fb-1 of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron Collider. The observed number of Bs and Bd candidates is consistent with background expectations. The resulting upper limits on the branching fractions are B(Bs-->mu+mu-) mu+mu-) < 1.8X10^-8 at 95% C.L.

  11. Search for Bs -> mu+mu- and Bd -> mu+mu- Decays in ppbar Collisions with CDF II

    CERN Document Server

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben-Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Bourov, S; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Connolly, A; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cruz, A; Cuevas-Maestro, J; Culbertson, R; Cyr, D; Da Ronco, S; D'Auria, S; D'Onofrio, M; Dagenhart, D; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, Mauro; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J; Di Turo, P; Dorr, C; Dominguez, A; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallinaro, M; Galyardt, J; García, J E; Garcia Sciverez, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D A; Gold, M; Goldschmidt, N; Goldstein, J; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimarães da Costa, J; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heijboer, A; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Höcker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, Y K; Kirby, M; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korytov, A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreps, M; Kreymer, A; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecci, C; LeCompte, T; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P; McNamara, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Murat, P; Nachtman, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Papikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K; Plager, C; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitine, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; Van Remortel, N; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sill, A; Sinervo, P; Sisakian, A; Sjölin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A W; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobuev, I P; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Worm, S; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, Y; Yang, C; Yang, U K; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

    2005-01-01

    We report on a search for Bs -> mu+mu- and Bd -> mu+mu- decays in ppbar collisions at sqrt(S) = 1.96 TeV using 364 pb-1 of data collected by the CDF II detector at the Fermilab Tevatron Collider. After applying all selection requirements, we observe no candidates inside the Bs or Bd mass windows, consistent with the background expectation. The resulting upper limits on the branching fractions are B(Bs -> mu+mu-) mu+mu-) < 3.9E-8 at 90% confidence level.

  12. Charmless Hadronic Two-body Decays of $B_{u}$ and $B_{d}$ Mesons

    CERN Document Server

    Chen, Y H; Tseng, B; Yang, K C; Chen, Yaw-Hwang; Cheng, Hai-Yang; Yang, Kwei-Chou

    1999-01-01

    Two-body charmless nonleptonic decays of B_u and B_d mesons are studied within the framework of generalized factorization in which the effective Wilson coefficients $c^{eff}_i$ are renormalization-scale and -scheme independent while factorization is applied to the tree-level hadronic matrix elements. Contrary to previous studies, our $c_i^{eff}$ do not suffer from gauge and infrared problems. Nonfactorizable effects are parametrized in terms of N_c(LL) and N_c(LR), the effective numbers of colors arising from (V-A)(V-A) and (V-A)(V+A) four-quark operators, respectively. Tree and penguin transitions are classified into six different classes. The data of $B^-\\to\\rho^0\\pi^-$ and $B^-\\to\\phi K^-$ clearly indicate that $N_c(LR)\

  13. [Therapeutic management of bipolar disorder in France and Europe: a multinational longitudinal study (WAVE-bd)].

    Science.gov (United States)

    Bellivier, F; Delavest, M; Coulomb, S; Figueira, M L; Langosch, J M; Souery, D; Vieta, E

    2014-10-01

    Bipolar disorder is a complex disease which requires multiple healthcare resources and complex medical care programs including pharmacological and non pharmacological treatment. If mood stabilizers remain the corner stone for bipolar disorder treatment, the development of atypical antipsychotics and their use as mood stabilizers has significantly modified therapeutic care. At the present time, psychiatrists have a large variety of psychotropic drugs for bipolar disorder: mood stabilizers, atypical antipsychotics, antidepressants, anxiolytics… However, despite the publication of guidelines on pharmacological treatment, with a high degree of consensus, everyday clinical practices remain heterogeneous. Moreover, there are few longitudinal studies to describe therapeutic management of bipolar disorder, whatever the phase of the disease is. Indeed, most of the studies are carried out on a specific phase of the disease or treatment. And there is no study comparing French and European practices. In this paper, we aim to present the comparison of the management of pharmacological treatments of bipolar disorder between France and Europe, using the data of the observational Wide AmbispectiVE study of the clinical management and burden of bipolar disorder (WAVE-bd study). The WAVE-bd study is a multinational, multicentre and non-interventional cohort study of patients diagnosed with BD type I or type II, according to DSM IV-TR criteria, in any phase of the disorder, who have experienced at least one mood event during the 12 months before enrolment. In total, 2507 patients have been included across 8 countries of Europe (480 in France). Data collection was retrospective (from 3 to 12 months), but also prospective (from 9 to 15 months) for a total study length of 12 to 27 months. Main outcome measures were the healthcare resource use and pharmacological treatments. Our results show differences in the therapeutic management of bipolar disorder between France and other European

  14. Mixing and CP-violation in the Bd and Bs systems at ATLAS

    CERN Document Server

    Wharton, Andrew Mark; The ATLAS collaboration

    2016-01-01

    Search for deviations from the standard model is performed in the systems of the neutral B mesons. The Bs system is studied in the decay into J/psi phi. The mixing phase phi_s and the width difference DeltaGamma_s are determined through the simultaneous study of angular distributions in the final state and of the decay time, performed together with flavour tagging at production. The measurement performed by ATLAS with the full LHC Run-1 sample is discussed and compared to the previous world average. The width difference DeltaGamma_d in the Bd system is obtained from the comparison of the decay time distributions in the flavour specific state J/psi K* and in the CP eigenstate J/psi KS. The result obtained from the full sample of data collected by ATLAS at 7 and 8 TeV is the most accurate single measurement of the width difference currently available.

  15. Near-Earth Asteroids 2006 RH120 AND 2009 BD: Proxies for Maximally Accessible Objects?

    Science.gov (United States)

    Barbee, Brent W.; Chodas, Paul W.

    2015-01-01

    NASA's Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) has identified over 1,400 of the approximately 12,800 currently known near-Earth asteroids (NEAs) as more astrodynamically accessible, round-trip, than Mars. Hundreds of those approximately 1,400 NEAs can be visited round-trip for less change-in-velocity than the lunar surface, and dozens can be visited round-trip for less change-in-velocity than low lunar orbit. How accessible might the millions of undiscovered NEAs be? We probe that question by investigating the hypothesis that NEAs 2006 RH120 and 2009 BD are proxies for the most accessible NEAs we would expect to find, and describing possible future NEA population model studies.

  16. Long-term perspectives of technical and social development in Germany. Visions for research and technology policy; Langfristige Perspektiven technischer und gesellschaftlicher Entwicklung in Deutschland. Visionen fuer die Forschungs- und Technologiepolitik

    Energy Technology Data Exchange (ETDEWEB)

    Baron, W.; Zweck, A.

    1995-12-01

    This publication contains six contributions discussing the medium- and long-term perspectives of technical, social and economic development in Germany. (UA) [Deutsch] Die vorliegende Publikation enthaelt 6 Vortraege, die sich mit mittel- und langfristigen Perspektiven der technischen, sozialen und wirtschaftlichen Entwicklung in Deutschland befassen. (UA)

  17. Transparency in power supply. Obligatory information on power sources in Germany and other countries; Transparenz fuer die Steckdose. Kennzeichnungspflicht fuer den Strommix: Einige Laender kennen sie bereits, und in Deutschland werden die Forderungen lauter

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, B.

    2001-07-01

    In California, it is obligatory for utilities to provide information on the sources of electric power. Austria will follow in October, and there is increasing pressure in Germany to introduce this option. [German] Auch in Deutschland werden die Forderungen nach einer Kennzeichnungspflicht fuer den Strommix immer lauter. In Kalifornien ist das bereits Standard, Oesterreich folgt im Oktober. (orig.)

  18. Die "Judenwissenschaft" im nationalsozialistischen Dritten Reich. Überlegungen zur "Forschungsabteilung Judenfrage" in Walter Franks "Reichsinstitut für Geschichte des neuen Deutschlands" und zu den Untersuchungen Tübinger Professoren zur "Judenfrage"

    DEFF Research Database (Denmark)

    Lammers, Karl Christian; Raphaël, Freddy

    2001-01-01

    Undersøgelse af den såkaldte "Judenwissenschaft" under det nazistiske Reichsinstitut für Geschichte des neuen Deutschlands, der havde tre professorer fra universitetet i Tübingen som vigtigste repræsentanter. Article on the socalled "Judenwissenschaft" under Walter Franks Reichsinstitut für Gesch...

  19. Entangled Bd mesons and genuine T, CP and CPT asymmetry parameters

    Science.gov (United States)

    Nebot, Miguel

    2017-07-01

    We establish the precise connection between the theoretical T, CP, CPT asymmetries, in terms of transition probabilities between the neutral meson Bd states, and the experimental asymmetries, in terms of the double decay rate intensities for Flavour-CP eigenstate decay products in a B-Factory of entangled states. Genuine asymmetry parameters in the time distribution of the asymmetries are identified and their measurability analysed, disentangling genuine and possible fake terms. The nine asymmetry parameters - three different observables for each one of the three symmetries - are expressed in terms of the ingredients of the Weisskopf-Wigner dynamical description of the entangled Bd -meson states and we obtain a global fit to their values from the BaBar Collaboration experimental results. The possible fake terms are all compatible with zero. The information content of the nine asymmetry parameters is indeed different. The non-vanishing {{Δ }}{{\\mathscr{l}}}c{{T}}=-0.687+/- 0.020 and {{Δ }}{{\\mathscr{l}}}c{{CP}}=-0.680+/- 0.021 are impressive separate direct evidence of Time-Reversal-Violation and CP-Violation in these transitions (and compatible with Standard Model expectations). A 2σ effect for the Re(θ) parameter responsible of CPT-Violation appears; interpreted as an upper limit, it leads to |{M}{\\bar{B}0{\\bar{B}}0}-{M}{B0{B}0}|adding an Entanglement-weakening term of the wrong exchange symmetry, the ω-effect. The analysis is extended to identify how to probe the complex ω when the connection between the Intensities for the two time-ordered decays (f, g) and (g, f) is lost (f flavour and g CP eigenstate decay channels), and how the ω-effect is disentangled from CPT violation in the evolution Hamiltonian.

  20. PHOTOIONIZATION MODELS OF THE INNER GASEOUS DISK OF THE HERBIG BE STAR BD+65 1637

    Energy Technology Data Exchange (ETDEWEB)

    Patel, P.; Sigut, T. A. A.; Landstreet, J. D., E-mail: ppatel54@uwo.ca [Department of Physics and Astronomy, The University of Western Ontario, London, Ontario Canada N6A 3K7 (Canada)

    2016-01-20

    We attempt to constrain the physical properties of the inner, gaseous disk of the Herbig Be star BD+65 1637 using non-LTE, circumstellar disk codes and observed spectra (3700–10500 Å) from the ESPaDOnS instrument on the Canada–France–Hawaii Telescope. The photoionizing radiation of the central star is assumed to be the sole source of input energy for the disk. We model optical and near-infrared emission lines that are thought to form in this region using standard techniques that have been successful in modeling the spectra of classical Be stars. By comparing synthetic line profiles of hydrogen, helium, iron, and calcium with the observed line profiles, we try to constrain the geometry, density structure, and kinematics of the gaseous disk. Reasonable matches have been found for all line profiles individually; however, no disk density model based on a single power law for the equatorial density was able to simultaneously fit all of the observed emission lines. Among the emission lines, the metal lines, especially the Ca ii IR triplet, seem to require higher disk densities than the other lines. Excluding the Ca ii lines, a model in which the equatorial disk density falls as 10{sup −10} (R{sub *}/R){sup 3} g cm{sup −3} seen at an inclination of 45° for a 50 R{sub *} disk provides reasonable matches to the overall line shapes and strengths. The Ca ii lines seem to require a shallower drop-off as 10{sup −10} (R{sub *}/R){sup 2} g cm{sup −3} to match their strength. More complex disk density models are likely required to refine the match to the BD+65 1637 spectrum.

  1. Expression of beta-defensins pBD-1 and pBD-2 along the small tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection

    NARCIS (Netherlands)

    Veldhuizen, E.J.; Dijk, van A.; Tersteeg, M.H.; Kalkhove, S.I.; Meulen, van der J.; Niewold, T.A.; Haagsman, H.P.

    2007-01-01

    Defensins are antimicrobial peptides that play an important role in the innate immune response in the intestine. Up to date, only one ß-defensin (pBD-1), has been described in pig, which was found to be expressed at low levels in the intestine. We set-up a quantitative PCR method to detect the gene

  2. The Design of the Vehicle Terminal System for Navigation Based on BD2/GPS Dual-mode%BD2/GPS双模车载导航终端系统设计

    Institute of Scientific and Technical Information of China (English)

    王华; 蒋玉东

    2013-01-01

    As a satellite navigation system that has independently developed and testablished by china, the use of the BDS wil fundamental y solve the problem of facing the risk of long-term dependence on GPS system. However, before the technology is not ful y mature, the dual-mode navigation based BD2/GPS wil be the development trend of the vehicle navigation. This paper presents a design program of the vehicle terminal system for navigation based on BD2/GPS dual-mode, including hardware and software systems, and describes the design ideas.%  作为中国自主研制和建立的卫星导航系统,BDS的运行将从根本上解决长期依赖于GPS系统面临的风险问题。但在技术没完全成熟之前, BD2/GPS双模导航将是车载导航的发展趋势。文章提出了一种基于BD2/GPS的双模车载导航终端系统的设计方案,包括硬件系统和软件系统,并介绍了设计思路。

  3. BD FACSAriaIII流式细胞仪在血液学中的使用分析研究%Application of BD FACSAriaIII flow cytometer in the research

    Institute of Scientific and Technical Information of China (English)

    梁昊岳; 程雪莲; 杨晚竹; 王金宏

    2014-01-01

    目的:对BD FACSAriaIII流式细胞仪在应用中出现的故障原因进行分析、研究,为在科研工作中正确使用该仪器提供依据。方法:通过对2012-2013年实验血液学国家重点实验室技术平台BD FACSAriaIII流式细胞仪的使用情况进行统计,对使用过程中出现的常见故障和需要由厂商工程师现场解决的故障进行统计,总结出高发故障的原因及解决方法。结果:通过对BD FACSAriaIII流式细胞仪的故障进行分析,为高通量流式细胞分选仪的正确使用提供指导,提高仪器运行的稳定性。结论:正确的使用和良好的维护有助于保证BD FACSAriaIII流式细胞仪的正常运行,从而确保科研工作的顺利进行。%Objective:To provide a basis for proper use of BD FACSAriaIII flow cytometer by analyzing the related causes of its malfunction.Methods: Through study of using BD FACSAriaIII flow cytometer in core facilities of State Key Laboratory of Experimental Hematology in 2012-2013, frequently occurred malfunction, solved malfunction by manufacturer’s engineers and their causes and solutions are summarized.Results: To provide guidance of using high throughput cell sorters and improve the stability of running the instrument.Conclusion: Proper use and good repair helps to guarantee the normal operation of BD FACSAriaIII flow cytometer.

  4. Exemplary subsurface geothermal projects in the western part of Germany; Beispiele zur Nutzung oberflaechennaher Geothermie im Westen Deutschlands

    Energy Technology Data Exchange (ETDEWEB)

    Sanner, B.; Mands, E. [UbeG GbR, Wetzlar (Germany); Kohlsch, O. [EWS Erdwaerme-Systemtechnik GmbH, Delbrueck (Germany)

    2004-12-01

    During the past few years, several projects involving ground source heat pumps were carried out in western Germany, especially in the Rhine-Main and Rhine-Ruhr-Sieg region including the cities of Frankfurt and Cologne. Some of the project partners are big names in industry, e.g. an office building of PhilipsSparte APD at Wetzlar and the museum building of chocolate producer Ritter Sport. Other projects are sited in rural regions, from the Black Forest to the Weserbergland hills. The contribution presents several interesting projects, e.g. the police headquarters building at Bonn (right bank, groundwater use) and the office building of the Federal Office of Environmental protection, also at Bonn (left bank, geothermal probles), and three school buildings in the Frankfurt/Main region at Glashuetten, Bad Homburg-Oberstedten and Usingen-Eschbach. (orig.) [German] In den letzten Jahren wurden im Westen Deutschlands eine ganze Reihe groesserer Projekte mit erdgekoppelten Waermepumpen verwirklicht, besonders im Rhein-Main-Gebiet und im Rhein-Ruhr-Sieg-Gebiet einschliesslich der Grossstaedte Frankfurt und Koeln. Zu den Bauherren zaehlen inzwischen auch bekannte Namen der deutschen Industrie. So wird in Wetzlar ein Buerogbaeude der PhilipsSparte APD mit Erdwaermesonden ausgeruestet, und das Museum des Schokoladenherstellers Ritter Sport wird auf Energiepfaehlen stehen. Abe auch im laendlichen Raum sind interessante Anlagen entstanden, vom Schwarzwald bis ins Weserbergland. Im Folgenden werden einige interessante Beispiele vorgestellt. Dabei sind Projekte in der Ausfuehrungsphase wie z.B. das Polizeipraesidium in Bonn (rechts des Rheins mit Grundwassernutzung), oder das Bundesamt fuer Naturschutz in Bonn, diesmal auf der linken Rheinseite und mit Erdwaermesonden. In Ausfuehrungn bzw. fertiggestellt sind auch Erdwaermesonden fuer 3 Schulen im Raum Frankfurt:/Main, in Glashuetten, Bad Homburg-Oberstedten und Usingen-Eschbach. (orig.)

  5. Die präkonzeptionelle Geschlechtswahl zu nichtmedizinischen Zwecken: Ergebnisse einer repräsentativen Bevölkerungsumfrage in Deutschland

    Directory of Open Access Journals (Sweden)

    Dahl E

    2004-01-01

    Full Text Available MicroSort (R, ein anscheinend sicheres und zuverlässiges Verfahren zur zytometrischen Trennung von X- und Y-Spermien, könnte schon bald das Interesse an der präkonzeptionellen Geschlechtswahl zu nichtmedizinischen Zwecken erhöhen. Es wird weithin angenommen, daß ein freier Zugang zu einer solchen Technologie das natürliche Gleichgewicht der Geschlechter stören werde. Damit es zu einem Ungleichgewicht des Geschlechterverhältnisses kommen kann, müssen jedoch mindestens zwei Bedingungen erfüllt sein. Erstens muß es eine statistisch signifikante Präferenz für Kinder eines ganz bestimmten Geschlechts geben und zweitens muß ein entsprechend hohes Interesse an der vorgeburtlichen Geschlechtswahl bestehen. Um zu prüfen, ob diese beiden Bedingungen erfüllt sind, haben wir eine repräsentative Bevölkerungsumfrage in Deutschland durchgeführt. Nach unseren Umfrageergebnissen gibt es keine signifikante Präferenz für Kinder eines bestimmten Geschlechts und nur ein geringes Interesse an der vorgeburtlichen Geschlechtswahl zu nichtmedizinischen Zwecken. Unter der Voraussetzung, daß unsere Daten die tatsächliche Einstellung der Bevölkerung widerspiegeln, würde ein freier Zugang zur präkonzeptionellen Geschlechtswahl nur einen marginalen sozialen Effekt in Deutschland haben.

  6. Use of coal and coal exit in Germany from the perspective of the population; Kohlenutzung und Kohleausstieg in Deutschland aus Sicht der Bevoelkerung

    Energy Technology Data Exchange (ETDEWEB)

    Schumann, Diana; Fischer, Wolfgang; Hake, Juergen-Friedrich [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie- und Klimaforschung, Systemforschung und Technologische Entwicklung (IEK-STE)

    2016-06-15

    The objective of the energy policy to reduce greenhouse gas emissions by 2050 up to 80 to 95% compared to 1990, can be achieved only by a substantial decarbonisation of the energy production. For this purpose, in addition to the assessment of the technical and economic effects, information is necessary which views the population has use to coal and coal exit in Germany. Based on the results of a representative panel survey is first identified what citizens know about the use of coal, which attitudes they have and how they value the need for coal power plants. Then the awareness of the topic of coal exit in Germany, the understanding of the respondents, and the attitudes of the population to it will be illustrated. [German] Die Zielsetzung der Energiewende, die Treibhausgasemissionen bis zum Jahr 2050 um 80 bis 95 % gegenueber 1990 zu reduzieren, laesst sich nur durch eine weitgehende Dekarbonisierung der Energieerzeugung erreichen. Hierfuer sind neben der Abschaetzung der technischen und oekonomischen Auswirkungen auch Informationen darueber notwendig, welche Auffassungen die Bevoelkerung zur Kohlenutzung und zum Kohleausstieg in Deutschland hat. Anhand der Ergebnisse einer repraesentativen Panelbefragung wird zunaechst aufgezeigt, was Buergerinnen und Buerger ueber die Kohlenutzung wissen, welche Einstellungen sie dazu haben und wie sie die Notwendigkeit von Kohlekraftwerken bewerten. Anschliessend werden die Bekanntheit des Themas Kohleausstieg in Deutschland, das Verstaendnis der Befragten und die Einstellungen der Bevoelkerung zu diesem beleuchtet.

  7. Information to go: Kommunikation im Prozess der Migration am Beispiel syrischer und irakischer Flüchtlinge auf ihrem Weg nach Deutschland

    Directory of Open Access Journals (Sweden)

    Anke Fiedler

    2016-07-01

    Full Text Available Vor dem Hintergrund der Flüchtlingsdebatte in Deutschland 2015 wird in diesem Beitrag danach gefragt, welche (Massen-Kommunikationskanäle Flüchtlinge vor, während und nach der Flucht nutzen, um sich über migrationsrelevante Themen zu informieren und sich darüber mit anderen Migrationswilligen auszutauschen. Dabei wird nicht nur die Frage nach der subjektiven Bewertung der genutzten Quellen gestellt, sondern auch untersucht, ob die Flüchtlinge eine informierte Entscheidung in den verschiedenen Phasen der Migration treffen. Auf Basis des Uses-and-Gratifications-Ansatzes und der Handlungstheorie (symbolischer Interaktionismus wurden zwischen November 2015 und Februar 2016 vier Fokusgruppen und 36 Tiefeninterviews mit syrischen und irakischen Flüchtlingen durchgeführt. Die Ergebnisse verdeutlichen, dass sich die befragten Flüchtlinge vor und während der Flucht gut informiert fühlten, da persönliche Kontakte und soziale Medien die Informationsbedürfnisse weitgehend befriedigen konnten. Informationsdefizite zeigten sich vor allem nach der Ankunft in Deutschland.

  8. New Possibility of Solving the Problem of Lifetime Ratio $\\tau (\\Lambda_b) / \\tau (B_d)$

    CERN Document Server

    Ito, T; Matsui, Y; Ito, Toshiaki; Matsuda, Masahisa; Matsui, Yoshimitsu

    1998-01-01

    We discuss the problem of the large discrepancy between the observed lifetime ratio of $B_d$ to $\\Lambda_b$ and the theoretical prediction obtained by the heavy quark effective theory. A new possibility of solving this problem is proposed from the viewpoint of operator product expansion and the lifetime ratio of $\\Lambda_b$ to $\\Omega_b$ is predicted.

  9. The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection

    Science.gov (United States)

    Shepherd, Mark; Achard, Maud E. S.; Idris, Adi; Totsika, Makrina; Phan, Minh-Duy; Peters, Kate M.; Sarkar, Sohinee; Ribeiro, Cláudia A.; Holyoake, Louise V.; Ladakis, Dimitrios; Ulett, Glen C.; Sweet, Matthew J.; Poole, Robert K.; McEwan, Alastair G.; Schembri, Mark A.

    2016-01-01

    Nitric oxide (NO) is a toxic free radical produced by neutrophils and macrophages in response to infection. Uropathogenic Escherichia coli (UPEC) induces a variety of defence mechanisms in response to NO, including direct NO detoxification (Hmp, NorVW, NrfA), iron-sulphur cluster repair (YtfE), and the expression of the NO-tolerant cytochrome bd-I respiratory oxidase (CydAB). The current study quantifies the relative contribution of these systems to UPEC growth and survival during infection. Loss of the flavohemoglobin Hmp and cytochrome bd-I elicit the greatest sensitivity to NO-mediated growth inhibition, whereas all but the periplasmic nitrite reductase NrfA provide protection against neutrophil killing and promote survival within activated macrophages. Intriguingly, the cytochrome bd-I respiratory oxidase was the only system that augmented UPEC survival in a mouse model after 2 days, suggesting that maintaining aerobic respiration under conditions of nitrosative stress is a key factor for host colonisation. These findings suggest that while UPEC have acquired a host of specialized mechanisms to evade nitrosative stresses, the cytochrome bd-I respiratory oxidase is the main contributor to NO tolerance and host colonisation under microaerobic conditions. This respiratory complex is therefore of major importance for the accumulation of high bacterial loads during infection of the urinary tract. PMID:27767067

  10. Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B

    NARCIS (Netherlands)

    Rasch, MC; Schellekens, H; van Dijck, CMM; Haagsma, EB; Michielsen, PP; van Buuren, AHJAM; Stotter, H; van Hattum, J

    1998-01-01

    A novel recombinant interferon-alpha B/D hybrid was applied to assess tolerability, antiviral effect, and biological activity in chronic hepatitis B. The study was designed as an open nonrandomized trial. Treatment comprised a two-week run-in phase with 16 MU three times a week followed by 14 weeks

  11. Working Effectively with Students with BD in a General Education Classroom: The Case for Universal Design for Learning

    Science.gov (United States)

    Johnson-Harris, Kimberly M.; Mundschenk, Nancy A.

    2014-01-01

    To one degree or another, inclusion is the word of the day in public schools across the country, and as a result many general education teachers find themselves face-to-face in their classrooms with students who have been diagnosed with behavior disorders (BD). While the behavior of these students is frequently (and euphemistically) referred to as…

  12. Sodium cromoglycate inhibits absorption of the major soybean allergen, Gly m Bd 30K, in mice and human intestinal Caco-2 cells.

    Science.gov (United States)

    Weangsripanaval, Thanakorn; Murota, Kaeko; Murakami, Yoko; Kominami, Masaru; Kusudo, Tatsuya; Moriyama, Tatsuya; Ogawa, Tadashi; Kawada, Teruo

    2006-11-01

    Our previous data showed that Gly m Bd 30K was absorbed from the gastrointestinal tract and circulated in blood in mice. This study was conducted to determine the mechanism and identify the inhibitor of such absorption. Using sandwich ELISA and immunoblotting, we found that intact Gly m Bd 30K was absorbed from apical to basolateral solutions and intracellularly accumulated by Caco-2 cells in a dose- and time-dependent manner. The absorption and intracellular accumulation of Gly m Bd 30K were significantly suppressed when Caco-2 cells were treated with sodium cromoglycate (SCG) (0-50 mmol/L) in a dose-dependent manner. In 24-d-old mice orally treated with SCG (10-1000 mg/kg body weight), plasma Gly m Bd 30K concentration decreased significantly 30-120 min after Gly m Bd 30K (2000 mg/kg body weight) administration. Moreover, inhibitors that suppress the clathrin-dependent endocytosis dansylcadaverine, the caveolae-dependent endocytosis nystatin and clathrin, and the caveolae-dependent endocytosis methyl-beta-cyclodextrin had inhibitory effects on the absorption and intracellular accumulation of Gly m Bd 30K by Caco-2 cells. These data indicate that Gly m Bd 30K is absorbed and intracellularly accumulated in Caco-2 cells via clathrin- or caveolae-dependent endocytosis. We propose that the absorption and intracellular accumulation of Gly m Bd 30K are inhibited by SCG via clathrin- or caveolae-dependent endocytosis.

  13. Adolf Reichwein, Frühschriften zur Erwachsenenbildung, 1920 – 1925. Pädagogische Schriften, hrsg. v. Ulrich Amlung, Bd. 1 Bad Heilbrunn: Klinkhardt 2011 (536 S.) [...] [Sammelrezension

    OpenAIRE

    Heuer, Klaus

    2011-01-01

    Sammelrezension von: 1. Adolf Reichwein: Frühschriften zur Erwachsenenbildung, 1920 – 1925, Pädagogische Schriften, hrsg. v. Ulrich Amlung, Bd. 1, Bad Heilbrunn: Klinkhardt 2011, 536 S. 2. Adolf Reichwein: Schriften zur Erwachsenen- und Arbeiterbildung, 1925 – 1929 Pädagogische Schriften, hrsg. v. Ulrich Amlung, Bd. 2, Bad Heilbrunn: Klinkhardt 2011, 496 S.

  14. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.

    Science.gov (United States)

    Sabino, Valentina; Cottone, Pietro; Zhao, Yu; Iyer, Malliga R; Steardo, Luca; Steardo, Luca; Rice, Kenner C; Conti, Bruno; Koob, George F; Zorrilla, Eric P

    2009-05-01

    Sigma-Receptors (SigRs) have been implicated in behavioral and appetitive effects of psychostimulants and may also modulate the motivating properties of ethanol. This study tested the hypothesis that SigRs modulate ethanol reinforcement and contribute to excessive ethanol intake. The effects of subcutaneous treatment with the potent, selective Sig-1R antagonist BD-1063 on operant ethanol self-administration were studied in two models of excessive drinking-Sardinian alcohol-preferring (sP) rats and acutely withdrawn ethanol-dependent Wistar rats-and compared to ethanol self-administration in nondependent Wistar controls. To assess the specificity of action, the effects of BD-1063 on self-administration of an equally reinforcing saccharin solution were determined in Wistar and sP rats. Gene expression of Sig-1R in reward-related brain areas implicated in ethanol reinforcement was compared between ethanol-naive sP and Wistar rats and withdrawn ethanol-dependent Wistar rats. BD-1063 dose dependently reduced ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that did not modify mean ethanol self-administration in nondependent Wistar controls. BD-1063 did not reduce concurrent water self-administration and did not comparably suppress saccharin self-administration, suggesting selectivity of action. BD-1063 also reduced the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. Ethanol-naive sP rats and 24-h withdrawn, dependent Wistar rats showed reduced Sig-1R mRNA expression in the nucleus accumbens. The results suggest that SigR systems may contribute to innate or ethanol-induced increases in susceptibility to self-administer high ethanol levels, identifying a potential neuroadaptive mechanism contributing to excessive drinking and a therapeutic target for alcohol abuse and dependence.

  15. Detection of Phosphorus, Sulphur, and Zinc in the Carbon-enhanced Metal-poor Star BD+44 493

    Science.gov (United States)

    Roederer, Ian U.; Placco, Vinicius M.; Beers, Timothy C.

    2016-06-01

    The carbon-enhanced metal-poor star BD+44°493 ([Fe/H] = -3.9) has been proposed as a candidate second-generation star enriched by metals from a single Pop III star. We report the first detections of P and S and the second detection of Zn in any extremely metal-poor carbon-enhanced star, using new spectra of BD+44°493 collected by the Cosmic Origins Spectrograph on the Hubble Space Telescope. We derive [P/Fe] = -0.34 ± 0.21, [S/Fe] = +0.07 ± 0.41, and [Zn/Fe] = -0.10 ± 0.24. We increase by 10-fold the number of Si i lines detected in BD+44°493, yielding [Si/Fe] = +0.15 ± 0.22. The [S/Fe] and [Zn/Fe] ratios exclude the hypothesis that the abundance pattern in BD+44°493 results from depletion of refractory elements onto dust grains. Comparison with zero-metallicity supernova (SN) models suggests that the stellar progenitor that enriched BD+44°493 was massive and ejected much less than 0.07 M ⊙ of 56Ni, characteristic of a faint SN. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute (STScI), which is operated by the Association of Universities for Research in Astronomy, Inc. (AURA) under NASA contract NAS 5-26555. These observations are associated with program GO-14231.

  16. A Member of the 14-3-3 Gene Family in Brachypodium distachyon, BdGF14d, Confers Salt Tolerance in Transgenic Tobacco Plants

    Science.gov (United States)

    He, Yuan; Zhang, Yang; Chen, Lihong; Wu, Chunlai; Luo, Qingchen; Zhang, Fan; Wei, Qiuhui; Li, Kexiu; Chang, Junli; Yang, Guangxiao; He, Guangyuan

    2017-01-01

    Plant 14-3-3 proteins are involved in diverse biological processes, but for the model monocotyledonous species, Brachypodium distachyon, their roles in abiotic stress tolerance are not well understood. In this study, a total of eight Bd14-3-3 genes were identified from B. distachyon and these were designated respectively as BdGF14a–BdGF14g. The qRT-PCR analyses of 3-month-old plants of B. distachyon showed that these genes were all expressed in the stems, leaves, and spikelets. By contrast, most of the plants had relatively lower transcriptional levels in their roots, except for the BdGF14g gene. The different expression profiles of the Bd14-3-3s under various stress treatments, and the diverse interaction patterns between Bd14-3-3s and BdAREB/ABFs, suggested that these gene products probably had a range of functions in the stress responses. The NaCl-induced Bd14-3-3 gene, BdGF14d, was selected for overexpression in tobacco. BdGF14d was found to be localized throughout the cell and it conferred enhanced tolerance to salt in the transgenic plants. Lowered contents of malondialdehyde, H2O2, and Na+, and lower relative electronic conductance (Rec%), yet greater activities of catalase and peroxidase, were observed in the overexpressing plants. Higher photosynthetic rate, transpiration rate, stomatal conductance, and water use efficiency were measured in the transgenic lines. Following abscisic acid (ABA) or NaCl treatment, stomatal aperture in leaves of the BdGF14d-overexpression plants was significantly lower than in leaves of the wild type (WT) controls. The stress-related marker genes involved in the ABA signaling pathway, the reactive oxygen species (ROS)-scavenging system, and the ion transporters were all up-regulated in the BdGF14d-overexpressing plants as compared with WT. Taken together, these results demonstrate that the Bd14-3-3 genes play important roles in abiotic stress tolerance. The ABA signaling pathway, the ROS-scavenging system, and ion

  17. Constructed a cell line to express hBD1 stablly and detected the antimicrobial activity of hBD1 to multidrug resistant bacterial strains%hBD1稳定表达细胞株的建立及其表达产物对多重耐药菌的活性检测

    Institute of Scientific and Technical Information of China (English)

    崔南; 陈新年; 魏莲花; 李娟; 邹凤梅

    2011-01-01

    目的 构建人β防御素1( hBD1)稳定表达细胞株并检测其对多种多重耐药菌的抗菌活性.方法 将重组质粒pCMV-hBD1通过阳离子脂质体转染于非洲绿猴SV40转化的肾细胞(COS-7细胞),经过G418压力筛选后获得单克隆细胞株;提取细胞总RNA,用RT-PCR检测目的基因在转录水平的表达;收集细胞培养上清液,用Western blot检测hBD1基因蛋白的表达;将含有表达产物hBD1的细胞培养上清液分别同各耐药菌液混合,37℃孵育不同时间后涂布于LB平板,以各实验组和对照组的菌落数的比值作为该耐药菌的存活率.结果 经过G418压力筛选所得到的稳定表达细胞株,在转录水平和蛋白水平均检测到目的基因hBD1的表达,在表达产物hBD1的作用下,多重耐药鲍氏不动杆菌、多重耐药大肠埃希菌存活率和多重耐药肺炎克雷伯杆菌的存活率可以分别降至9%、22%和50%,多重耐药嗜麦芽窄食单胞菌的存活率同对照组没有明显差异.结论 成功获得hBD1稳定表达细胞株,目的基因hBD1的表达产物对多种多重耐药菌均具有抗菌活性.%Objective To established a cell line that expresses hBD1 stably,and detected the antimicrobial activity of the hBD1 to the muhidrug resistant bacterial strains.Methods Recombinant plasmid was introduced into COS-7 cells by lipofectamine,cells were selected in culture medium containing G418 to acquired the monoclonal cell lines,total RNA were extracted from the cultured cells,expression levels of hBD1 mRNA was identified by RT-PCR,collected the supernatant solution of the cultured cell,expression levels of protein was identified by Western blot.Put the expression products and resistant organisms mixed together,after incubation in different times in 37℃,coating the mixtures in LB flat,then obtained the ratios between colonies number of experimental groups and colonies number of control groups,put those ratios as the survival rate of the drug

  18. Molecular detection of common intestinal parasites: a performance evaluation of the BD Max™ Enteric Parasite Panel.

    Science.gov (United States)

    Batra, R; Judd, E; Eling, J; Newsholme, W; Goldenberg, S D

    2016-11-01

    The purpose of this study was to evaluate the level of agreement of the BD Max™ Enteric Parasite Panel (EPP) with microscopy for the detection of Giardia duodenalis, Cryptosporidium spp. and Entamoeba histolytica in stool samples. A total of 372 stool samples (partly collected on the basis of positive microscopy and partly unselected, consecutive sample submitted for parasite investigation) were tested with EPP according to manufacturer's instructions and also using microscopy according to standard techniques. Discrepant samples were further tested using PCR by the National Parasitology reference laboratory. Levels of agreement and laboratory turnaround times were measured and compared. Overall, positive and negative percent agreement was high between the two methods. However, microscopy resulted in four false positives and one false negative for G. duodenalis and two false positives for Cryptosporidium. Additionally, microscopy could not differentiate between E. histolytica and Entamoeba dispar. Median laboratory turnaround time was 65 hours for microscopy; results from EPP could be available after four hours. Blastocycstis hominis was detected by microscopy in one sample and would have been missed if only EPP was performed. The EPP was a good alternative to microscopy, detecting a small number of additional positives that were missed by microscopy. The assay is significantly faster than microscopy and allows laboratory workflows to be streamlined. The risk of missing parasites that are not included in the EPP appears to be minimal in the studied population; however, there may be certain patient groups who would benefit from microscopic examination of stools.

  19. Longevity Tests of High-Sensitivity BD-PND Bubble Dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Radev, R; Carlberg, E

    2002-07-09

    Medium- and very-high-sensitivity neutron bubble dosimeters (BD-PNDs) made by Bubble Technology Industries (BTI) were used to study the life span of such dosimeters in a standard setup with a {sup 252}Cf source. Although data on the longevity of bubble dosimeters with low and medium sensitivity exist, such data for dosimeters with high and very high sensitivity are not readily available. The manufacturer guarantees optimum dosimeter performance for 3 months after receipt. However, it is important to know the change in the dosimeters' characteristics with time, especially after the first 3 months. The long-term performance of four sets of very high sensitivity and one set of medium-sensitivity bubble dosimeters was examined for periods of up to 13 months. During that time, the detectors were exposed and reset more than 20 times. Although departures from initial detection sensitivity were observed in several cases, the detectors indicated a significantly longer life span than stated in the manufacturer's warranty. In addition, the change in the number of bubbles and in evaluated neutron dose as a function of the time from the end of exposure until the dosimeters were read was investigated.

  20. Modified electrochemical parameter estimation of NCR18650BD battery using implicit finite volume method

    Science.gov (United States)

    Ashwin, T. R.; McGordon, A.; Widanage, W. D.; Jennings, P. A.

    2017-02-01

    The Pseudo Two Dimensional (P2D) porous electrode model is less preferred for real time calculations due to the high computational expense and complexity in obtaining the wide range of electro-chemical parameters despite of its superior accuracy. This paper presents a finite volume based method for re-parametrising the P2D model for any cell chemistry with uncertainty in determining precise electrochemical parameters. The re-parametrisation is achieved by solving a quadratic form of the Butler-Volmer equation and modifying the anode open circuit voltage based on experimental values. Thus the only experimental result, needed to re-parametrise the cell, reduces to the measurement of discharge voltage for any C-rate. The proposed method is validated against the 1C discharge data and an actual drive cycle of a NCR18650BD battery with NCA chemistry when driving in an urban environment with frequent accelerations and regenerative braking events. The error limit of the present model is compared with the electro-chemical prediction of LiyCoO2 battery and found to be superior to the accuracy of the model presented in the literature.

  1. The Angular Expansion and Distance of the Planetary Nebula BD+30 3639

    CERN Document Server

    Li, J; Borkowski, K J; Li, Jianyang; Borkowski, Kazimierz J.

    2002-01-01

    The WFPC2 camera aboard the HST was used to obtain images of the planetary nebula BD+30 3639 at two epochs separated by 5.663 years. The expansion of the nebula in the H-alpha and [N II] bands has been measured using several methods. Detailed expansion maps for both emission lines were constructed from nearly 200 almost independent features. There is good agreement between the (independent) H-alpha and [N II] proper motions. The central velocity split is measured from the STIS echelle spectra of the C II] 2326A multiplet to be +/-36.3 km/s at a position angle of 99 degrees. The angular displacement along this slit position was measured to be 4.25 mas/yr at 2".47 from the center. We constructed a tilted ellipsoidal shell model by fitting the radio brightness variation of the 5 and 15 GHz VLA observations, and making use of the ground-based echelle spectra from Bryce & Mellema (1999), to estimate distance. Our model has an axial ratio of 1.56, is inclined to the line of sight by 9.7 degrees, and exhibits an...

  2. Agrowaste to vanillin conversion by a natural Pediococcus acidilactici strain BD16.

    Science.gov (United States)

    Chakraborty, Debkumar; Kaur, Baljinder; Obulisamy, Karthikeyan; Selvam, Ammaiyappan; Wong, Jonathan W C

    2016-10-13

    Owing to its flavoring, antimicrobial, antioxidant and anticarcinogenic nature, vanillin is widely used in foods, beverages, perfumes and pharmaceutical products. Ferulic acid (FA) is an important precursor of vanillin which is abundant in cereals like maize, rice and wheat and sugar beet. A major drawback of microbial vanillin production from FA is the degradation and biotransformation of toxic vanillin to other phenolic derivatives. The present study is undertaken to explore microbial vanillin production from FA precursor rice bran by employing vanillin-resistant Pediococcus acidilactici BD16, a natural lactic acid bacteria isolate. Extracellular, intracellular and cellular vanillin dehydrogenase activity was found least, which was minimized vanillin degradation, and the strain resists more than 5 g L(-1) vanillin in the medium. A metabolomics approach was followed for the detection of FA, vanillin and other metabolites generated during fermentation of rice bran medium. A metabolic pathway was also predicted for vanillin biosynthesis. Approximately 1.06 g L(-1) of crude vanillin was recovered from rice-bran-containing medium and this further offers scope for the industrial utilization of the organism and its genetic manipulation to enhance production of biovanillin.

  3. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

    Directory of Open Access Journals (Sweden)

    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  4. Research of smoothing pseudo-range algorithm by Doppler based on GPS/BD

    Science.gov (United States)

    Kang, Chuanli; Zhou, Yanliu

    2015-12-01

    GNSS (Global Navigation Satellite System) technology not only in the general field of surveying and mapping, geology, mining, water and electricity, and in particular in the field of public security, fire protection, tourism, search and rescue, adventure have been more widely used. These special areas require real-time and high positioning accuracy. Currently, GNSS precision positioning technology has become a hot research direction. This paper introduced an algorithm of smoothing pseudo range by Doppler based GPS/BD to improve GNSS positioning precision. This algorithm decoded the pseudo range data and ephemeris data, and then designed algorithm of smoothing pseudo range by Doppler according principle of Doppler smoothing pseudo range. This algorithm was realized by C++ and proved its efficiency. At last, this algorithm has proved its correctness through calculating and analyzing practical Doppler and pseudo range data, and then a conclusion has been obtained: the Doppler value precision is sub-meter, far better than the pseudo-range accuracy, so that if the two data are combined to calculate position that can help to improve the positioning accuracy.

  5. Expressão cutânea das β-defensinas (cBD102 e cBD103) em cães acometidos por leishmaniose visceral

    OpenAIRE

    Hernandez, Fernely Augusto Plazas

    2012-01-01

    Em resposta a uma infeção as defensinas são produzidas em questão de minutos ou até 2 horas por células sanguíneas como neutrófilos, para auxiliar a lise de patógenos e estimular a quimiotaxia, alcançando níveis máximos no organismo em 24 horas. Também estes peptídeos podem ser produzidos sem estimulo algum pelas células epiteliais do sistema tegumentário. Com base no exposto anteriormente, o objetivo deste trabalho foi estudar a expressão de β-defensinas (cBD102 e cBD103) de pele de cãe...

  6. Performance of Combined GPS/BD Positioning%GPS/BD组合导航定位试验和精度分析

    Institute of Scientific and Technical Information of China (English)

    刘季; 张小红

    2012-01-01

    We discussed some main issues of combined GPS/BD single point positioning. A pro- gram was developed to process the combined GPS/BD data. Availability and positioning accuracy of BD and combined GPS/BD were analyzed. Preliminary results show that BD can provide re- gional navigation and positioning service with a accuracy of around 15 meters. Combined GP, S and BD cannot improve positioning accuracy under the condition that enough visible GPS satellites are available. In the case of bad GPS satellites geometry with insufficient visible GPS satellites, com- bined GPS/BD can improve positioning stability and accuracy.%讨论了GPS/BD组合定位需要考虑的主要问题,自编了GPS/BD组合定位程序,利用实测GPS/BD观测数据分析了当前北斗导航定位系统可用性及GPS/BD组合前后的定位精度。试验结果表明,北斗已经能够提供区域的实时导航定位服务。GPS/BD组合定位在GPS观测卫星数较多时对GPS定位精度改善不明显,在GPS观测卫星数较少时可以显著提高定位精度和稳定性。

  7. X-ray Observations of Bow Shocks around Runaway O Stars. The case of $\\zeta$ Oph and BD+433654

    CERN Document Server

    Toalá, J A; González-Gaán, A; Guerrero, M A; Ignace, R; Pohl, M

    2016-01-01

    Non-thermal radiation has been predicted within bow shocks around runaway stars by recent theoretical works. We present X-ray observations towards the runaway stars $\\zeta$ Oph (Chandra and Suzaku) and BD+433654 (XMM-Newton) to search for the presence of non-thermal X-ray emission. We found no evidence of non-thermal emission spatially coincident with the bow shocks, nonetheless, diffuse emission is detected in the vicinity of $\\zeta$ Oph. After a careful analysis of its spectral characteristics we conclude that this emission has a thermal nature with a plasma temperature of $T \\approx 2 \\times10^{6}$ K. The cometary shape of this emission seems to be in line with recent predictions of radiation-hydrodynamic models of runaway stars. The case of BD+433654 is puzzling as non-thermal emission has been reported in a previous work for this source.

  8. Comparative Evaluation of Inoculation of Urine Samples with the Copan WASP® and BD Kiestra™ InoqulA™ Instruments

    DEFF Research Database (Denmark)

    Iversen, Jesper; Stendal, Gitta; Gerdes, Cecilie Marie

    2016-01-01

    This study evaluated quantitative results as well as the quality of the inoculation patterns on urine specimens produced by two automated instruments, the Copan WASP® and the BD InoqulA™. 526 urine samples submitted in 10 ml canisters containing boric acid were processed within 30 minutes...... on an InoqulA, plating 10 ul of specimen, and two WASP instruments, one plating 1 ul of specimen (WASP-1) and the second WASP 10 ul (WASP-10). All samples were incubated, analysed, and digitally imaged using the BD Kiestra™ Total Lab Automation system. Results were evaluated using a quantitative protocol...... of the automated instruments divided by the counts for the calibrated pipet (golden standard). Ratios for the InoqulA were closest to 1,0 with the smallest standard deviations indicating that, compared to a calibrated pipet, the InoqulA results were more accurate than the WASP.. For clinical samples, the WASPs...

  9. Raimbaut de Vaqueiras, “[Oi] altas undas que venez suz la mar” (BdT 392.5a

    Directory of Open Access Journals (Sweden)

    Saverio Guida

    2013-06-01

    Full Text Available The aim of the present paper is to return to the discussion on the authorship of BdT 392.5 and argue for attributing the poem to Raimbaut de Vaqueiras. I believe that the affinities in theme, situation and expression between “[Oi] altas undas que venez suz la mar” and the song “Belh Monruelh” (BdT 70.11, that I tried to link to Raimbaut in a previous study, should not be overlooked. An important clue is that the wind motif, present in the latter song, also occurs several times in the Occitan troubadour’s production, to the extent that it would seem a tried and tested semiotic marker. Neither should the underlying narrative quality of the text in search of an author be ignored, nor the popular tone that characterizes it, which are both compatible with attitudes expressed by the “fill d’un paubre cavaillier de Proensa”, who frequently makes use of popular song and does not shun the adoption and elevation in a classless manner of features of more ‘humble’ origin. Moreover, of utmost importance is the use in l. 10 of BdT 392.5a of the verb-form “aportai”, an imperative form (confirmed by the rhyme found in northern Italy (and in particular in the Liguria-Piedmont area, where Raimbaut spent many years and which is employed, as a clear dialect feature, significantly in l. 27 of the ‘tenso’ between the Occitan troubadour and the Genoese lady (BdT 392.7.

  10. Valproat-assoziierte Enzephalopathie - 19 neue Fälle in Deutschland zwischen 1994 und 2003 - eine Nebenwirkung nicht nur bei jüngeren Kindern

    Directory of Open Access Journals (Sweden)

    Gerstner T

    2007-01-01

    Full Text Available Valproat (VPA ist ein Breitspektrum-Antiepileptikum und wird in der Regel sehr gut toleriert. Seltene schwere Nebenwirkungen können allerdings auftreten, einschließlich einer hämorrhagischen Pankreatitis, Gerinnungsstörungen, Leberversagen und Enzephalopathien. Die typischen Zeichen einer Enzephalopathie sind Konzentrationsstörungen, EEG-Verlangsamungen und eine erhöhte Anfallsfrequenz mit oder ohne Hyperammonämie. Noch immer gibt es keinen Beweis für die Kausalität zwischen VPA und Enzephalopathie, aber eine deutliche Assoziation. Wir berichten über 19 neue, unveröffentlichte Fälle dieser Nebenwirkung im Zeitraum von 1994–2003 aus Deutschland.

  11. Practical experience with biodegradable biomass waste bags in several different German composting plants; Praxiserfahrungen zum Abbau kompostierbarer Bioabfallsaecke auf verschiedenen Kompostierungsanlagen in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Ziermann, Andreas; Schmidt, Bettina [C.A.R.M.E.N. e.V., Straubing (Germany)

    2012-11-01

    The study intended to find out how fast biodegradable biomass waste bags are degraded in practical conditions in composting and fermentation plants. The plants differ with regard to the processes employed; further, rotting times may be much shorter in practice than the twelve weeks requested by DIN EN 13432 and DIN EN 14995. For the study, plant types were selected that are practically relevant for biomass waste utilisation in Germany. (orig.) [German] Ziel der vorliegenden Studie war es, herauszufinden, wie schnell kompostierbare Bioabfallsaecke unter Praxisbedingungen in verschiedenen Kompost- und Vergaerungsanlagentypen abgebaut werden. Zum einen bestehen teilweise grosse verfahrenstechnische Unterschiede zwischen den Anlagentypen, zum anderen sind die Rottezeiten in der Praxis zum Teil wesentlich kuerzer, als die in der DIN EN 13432 und DIN EN 14995 geforderten zwoelf Wochen. Fuer die Studie wurden Anlagentypen ausgewaehlt, die fuer die Verwertung von Bioabfaellen in Deutschland praxisrelevant sind. (orig.)

  12. Raw materials and energy - effects of globalization on the safety of German's supply sufficiency; Rohstoffe und Energie. Auswirkungen der Globalisierung auf die Versorgungssicherheit Deutschlands

    Energy Technology Data Exchange (ETDEWEB)

    Wellmer, F.W. [Technische Univ. Berlin (Germany)

    2001-07-01

    Raw material deposits are not mobile, so globalisation has always been an important element of raw materials production and trade. Raw materials production and transport should be regarded as a large-scale system. Lower freight rates have made overseas transport possible even for bulk raw materials. If we look at Germany's raw materials supply, we find that we are customers buying from the whole world. [German] Da Lagerstaetten ortsgebunden sind, ist Globalisierung seit jeher ein wesentliches Element von Rohstoffgewinnung und handel. Rohstoffgewinnung und Transportmoeglichkeiten muessen als Grosssystem betrachtet werden. Nicht zuletzt wegen der gesunkenen Frachtraten ist der ueberseeische Transport heute selbst fuer Massenrohstoffe moeglich geworden. Betrachtet man die Rohstoffversorgung Deutschlands, wird deutlich, dass wir Kunde der ganzen Welt sind. (orig.)

  13. Protection provided by criminal law against hazards of nuclear energy and the harmful effects of ionizing radiation. Also a survey of the history of definition of offences against the atomic energy law and radiation protection law in the Federal Republic of Germany. Der strafrechtliche Schutz vor den Gefahren der Kernenergie und den schaedlichen Wirkungen ionisierender Strahlen. Zugleich eine Darstellung der historischen Entwicklung der Kernenergie- und Strahlendelikte in der Bundesrepublik Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Reinhardt, M.

    1989-01-01

    The subjects, principles and purpose of the atomic energy law and the radiation protection law are set out, and criminal offences under atomic energy law are outlined explaining the legal terminology applied. The peaceful uses of nuclear energy and radioactive materials are briefly discussed, primarily looking at the hazards involved and the protective role of criminal law principles that have been developed in connection with the atomic energy law and its application in practice. The draft version of the 16th criminal law amendment act - Act to combat environmental delinquency - is discussed, which aims at adoption of all criminal offences under atomic energy law by the Criminal Code. The book furthermore presents considerations about basic features of delinquency under atomic energy and radiation protection law, revealing elements and facts of offences defined, and particular problems resulting thereof. The question arises, e.g., whether an incorporation of the provisions into the Special Annex to the Criminal Code, in sections 27 and 28, is a wise and suitable decision. The book finally discusses the development of definition of criminal offences by a de lege feranda approach, referring to (1) the Chernobyl reactor accident, (2) the Nuclear Safeguards agreements, and (3) the definition of maximum permissible radiation dose. (HP).

  14. Environmental policy. Resolution of the German Federal Government concerning the Air Pollution Abatement Programme of the Federal Republic of Germany based on the fourth report of the Interdepartmental Working Group on Carbon Dioxide Reduction (IMA `CO{sub 2} Reduction`); Umweltpolitik. Beschluss der Bundesregierung zum Klimaschutzprogramm der Bundesrepublik Deutschland auf der Basis des Vierten Berichts der Interministeriellen Arbeitsgruppe ``CO{sub 2}-Reduktion`` (IMA ``CO{sub 2}-Reduktion``)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    Air pollution abatement is a key issue in German environmental policy. This was stressed again in the 4th report of the Interdepartmental Working Group on Carbon Dioxide Reduction (IMA `CO{sub 2}-Reduktion`), in which the Federal Government confirmed its goal of a 25% reduction of carbon dioxide emissions by 2005 as referred to 1990. This report contains the government decision, the formulatio of the task assigned to the IMA, and the 4th report of the IMA. (orig./SR) [Deutsch] Klimavorsorge ist ein Schwerpunkt der deutschen Umweltpolitik. Dies hat das Bundeskabinett mit der Verabschiedung des 4. Berichts der Interministeriellen Arbeitsgruppe (IMA) ``CO{sub 2}-Reduktion`` nachdruecklich unterstrichen. Mit diesem Beschluss bekraeftigt die Bundesregierung erneut ihr Ziel, die CO{sub 2} Emissionen bis 2005 um 25 % gegenueber 1990 zu senken. Der vorliegende Bericht enthaelt den Beschluss, der Bundesregierung, den Auftrag der Bundesregierung an die Interministerielle Arbeitsgruppe (IMA) und den 4. Bericht der IMA ``CO{sub 2}-Reduktion``. (orig./SR)

  15. High level expression of human epithelial β-defensins (hBD-1, 2 and 3 in papillomavirus induced lesions

    Directory of Open Access Journals (Sweden)

    Chong Kong T

    2006-09-01

    Full Text Available Abstract Background Epithelial defensins including human β-defensins (hBDs and α-defensins (HDs are antimicrobial peptides that play important roles in the mucosal defense system. However, the role of defensins in papillomavirus induced epithelial lesions is unknown. Results Papilloma tissues were prospectively collected from 15 patients with recurrent respiratory papillomatosis (RRP and analyzed for defensins and chemokine IL-8 expression by quantitative, reverse-transcriptase polymerase chain reaction (RT-PCR assays. HBD-1, -2 and -3 mRNAs were detectable in papilloma samples from all RRP patients and the levels were higher than in normal oral mucosal tissues from healthy individuals. Immunohistochemical analysis showed that both hBD-1 and 2 were localized in the upper epithelial layers of papilloma tissues. Expression of hBD-2 and hBD-3 appeared to be correlated as indicated by scatter plot analysis (r = 0.837, p Conclusion Human β-defensins are upregulated in respiratory papillomas. This novel finding suggests that hBDs might contribute to innate and adaptive immune responses targeted against papillomavirus-induced epithelial lesions.

  16. Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats.

    Science.gov (United States)

    Carter, Lawrence P; Koek, Wouter; France, Charles P

    2006-11-01

    Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally worldwide. Since the scheduling of GHB by the USA and the United Nations in 2000-2001, the recreational use of GHB precursors has reportedly increased. The aim of this study was to examine if potency differences of GHB and GHB-like compounds are due to their blood-brain barrier permeability. The effects of peripheral and central administration of GHB, GHB precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), and the gamma-aminobutyric acid (GABA)(B) receptor agonist baclofen on schedule-controlled responding were examined in rats. GHB and baclofen were 276- and 253-fold more potent, respectively, after intracerebroventricular (i.c.v.) administration than after intraperitoneal (i.p.) administration, whereas GBL and 1,4-BD, up to a dose of 1780 microg were without effect after i.c.v. administration. These data suggest that GBL and 1,4-BD are not metabolically converted to GHB in the brain, that enhanced brain penetration cannot account for potency differences between compounds, and that baclofen, like GHB, can readily cross the blood-brain barrier.

  17. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  18. Markus Gamper: Islamischer Feminismus in Deutschland? Religiosität, Identität und Gender in muslimischen Frauenvereinen. Bielefeld: transcript Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Charlotte Binder

    2011-12-01

    Full Text Available Anhand von qualitativen und quantitativen Daten wird in dieser soziologischen Studie die Bedeutung von Religiosität, Identität und Gender in muslimischen Frauenvereinen in Deutschland untersucht. Markus Gamper verknüpft die Ergebnisse mit den kulturtheoretischen Ansätzen von Stuart Hall und Homi K. Bhabha und vertritt die These, dass ein islamischer Feminismus in Deutschland existiere. Er stellt fest, dass es den in den Vereinen organisierten Frauen gelinge, Gegendiskurse zu der deutschen Mehrheitsgesellschaft sowie zu den androzentrisch geprägten muslimischen Gemeinschaften zu entwickeln und somit Widerstand gegen Diskriminierung zu leisten. Der Autor begegnet in den von ihm untersuchten Vereinen – statt ‚unterdrückten Muslima‘, wie sie von den Medien inszeniert werden – hochgebildeten Frauen, die selbstbewusst und unabhängig ein religiöses Leben führen.Using qualitative and quantitative data, this sociological study analyzes the meaning of religiosity, identity, and gender in Muslim women’s societies in Germany. Markus Gamper connects the findings to approaches from the field of cultural theory by Stuart Hall and Homi K. Bhabha. Furthermore, he advocates the proposition that Islamic feminism exists in Germany. He states that the women who are organized in these societies succeed in developing counter discourses to German mainstream society as well as to the androcentrically coined Muslim communities, thus, making a stand against discrimination. In the analyzed societies, the author encounters – instead of “suppressed Muslim women” as they are presented by the media – highly educated women, who, confidently and independently, lead a religious life.

  19. Aufwind und Gegenwind. Erfahrungen mit und aus einem Frauenstudiengang in Deutschland Tailwind and Headwind—Experiences With and From a Women’s Studies Program in Germany

    Directory of Open Access Journals (Sweden)

    Anina Mischau

    2004-11-01

    Full Text Available Derzeit gibt es (an Fachhochschulen in Deutschland (noch vier (teil-monoedukative Studienangebote für Frauen. Der erste „Frauenstudiengang“ startete zum Wintersemester 1997/98 in Wilhelmshaven, der „jüngste“ im Sommersemester 2002 in Furtwangen. Diese „Frauenstudiengänge“ treffen bis heute in Politik, Wissenschaft und Wirtschaft nicht nur auf Befürworter/-innen, sondern noch immer auf große Skepsis, auf Vorurteile sowie auf erklärte Gegner/-innen. Beide Gruppen verfolgen die Entwicklung dieser bildungs- wie geschlechterpolitischen Reformmaßnahmen mit „Argusaugen“, um ihre Argumente für das „Für und Wider“ einer Geschlechtertrennung, ihre Prognosen über deren „Erfolg“ oder „Misserfolg“ durch praktische Erfahrungen „bestätigt“ zu sehen. Mit dem Buch von Gudrun-Axeli Knapp und Carmen Gransee liegt nun die erste abgeschlossene Begleitforschung zum „ältesten“ Frauenstudiengang in Deutschland vor. Auch der Sammelband von Carmen Gransee bezieht sich auf Erfahrungen aus Wilhelmshaven und bettet diese in einen umfassenderen Diskurs ein. Beiden Büchern kommt daher für eine kritische Reflexion und mögliche Neuorientierung, aber auch für die Frage nach den Chancen einer nachhaltigen Institutionalisierung und Ausweitung von Frauenstudiengängen an deutschen Hochschulen eine „exponierte“ Bedeutung zu.mshaven and contextualizes these experiences in a more inclusive discourse. Both books are thus given a „prominent“ position for critical reflection on and possible new directions of Women’s Studies Programs as well as for the question of the probability of a sustainable institutionalization and expansion of Women’s Studies Programs at German institutions of higher education.

  20. Umkehr von Frühverrentung in Deutschland Eine Längsschnittanalyse der Auswirkungen der jüngsten Rentenreformen auf den Zeitpunkt des Erwerbsausstiegs und die Rentenhöhe

    Directory of Open Access Journals (Sweden)

    Dr. Sandra Buchholz

    2013-12-01

    Full Text Available Dieser Beitrag untersucht die Auswirkungen und Risiken der jüngsten Rentenreformen in Deutschland. Während die deutsche Rentenpolitik über viele Jahre systematisch die Frühverrentung gefördert hat, um den regulierten Arbeitsmarkt in Zeiten wirtschaftlicher Stagnation zu entlasten, hat die Rentenpolitik in der jüngeren Vergangenheit einen deutlichen Paradigmenwechsel erfahren. Die jüngsten Reformen gehen von einem längeren Verbleib älterer Arbeitnehmer im Erwerbsleben aus. Anhand von Daten des Sozio-oekonomischen Panels (SOEP sowie mithilfe von Längsschnittanalysen auf Mikroebene kommt dieser Beitrag zu dem Ergebnis, dass die aktuelle Trendwende im Bereich der Frühverrentung in Deutschland auf Kosten zunehmender sozialer Ungleichheiten innerhalb der älteren Bevölkerung geht.

  1. 13 CFR 124.110 - Do Native Hawaiian Organizations have any special rules for applying to the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ...) BD program as its primary SIC code. (d) SBA does not deem an individual involved in the management or...: (i) The technical and managerial experience and competence of the individual(s) who will manage...

  2. Effect of chloride substitution on the order–disorder transition in NaBH{sub 4} and Na{sup 11}BD{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, Jørn Eirik [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Karen, Pavel [University of Oslo, Department of Chemistry, P.O. Box 1033 Blindern, NO-0315 Oslo (Norway); Sørby, Magnus H. [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Hauback, Bjørn C., E-mail: bjorn.hauback@ife.no [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway)

    2014-02-25

    Graphical abstract: Interactions that order the BD{sub 4}{sup -} tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH{sub 4}){sub 1−x}Cl{sub x} and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na{sup 11}BD{sub 4} at room temperature and 8 K and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na{sup 11}BD{sub 4} (NaBH{sub 4}) and its solid solutions with NaCl, Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x}, is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na{sup 11}BD{sub 4}, ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na{sup 11}BD{sub 4}) at 8 K.

  3. Development and validation of the BD SX: a brief measure of mood and symptom variability for use with adults with bipolar disorder.

    Science.gov (United States)

    O'Rourke, Norm; Sixsmith, Andrew; King, David B; Yaghoubi-Shahir, Hamed; Canham, Sarah L

    2016-12-01

    Ecological momentary sampling in BD research requires brief symptom measures with low cognitive demands to maximize data collection across the range of BD symptomatology. We developed the BD Sx cognizant of the challenges inherent in scale development with low prevalence populations and the limitations of existing measures (e.g., over-reliance on patients in acute states recruited from psychiatric settings). In order to be generalizable across the full spectrum of the illness, we also included those currently euthymic and those who avoid clinical contact. We recruited a global sample of 1010 adults with BD over 19 days using socio-demographically targeted, social media advertising and online data collection. At follow-up, 428 participants provided responses 67 days later on average. This enabled us to develop the BD Sx and replicate initial findings across multiple samples over time. Both exploratory and confirmatory factor analyses support a 4-factor BD Sx model. Goodness of fit indices indicate good model fit across samples and over time. We labeled these factors: elation/loss of insight, affrontive symptoms of mania, cognitive/depressive, and somatic/depressive symptoms. Affrontive symptoms correlate positively with cognitive and somatic depression factors, which may suggest mixed-state symptom clusters in accord with DSM 5. Responses to the BD Sx reliably measure both depressive and hypo/manic symptoms. Temporal invariance analyses indicate that the 4-factor structure is consistent over time. Future research  should compare BD Sx responses to clinical diagnoses of hypo/mania and major depressive episodes.

  4. Antiadhesive activity of the biosurfactant pseudofactin II secreted by the Arctic bacterium Pseudomonas fluorescens BD5

    Directory of Open Access Journals (Sweden)

    Janek Tomasz

    2012-02-01

    Full Text Available Abstract Background Pseudofactin II is a recently identified biosurfactant secreted by Pseudomonas fluorescens BD5, the strain obtained from freshwater from the Arctic Archipelago of Svalbard. Pseudofactin II is a novel compound identified as cyclic lipopeptide with a palmitic acid connected to the terminal amino group of eighth amino acid in peptide moiety. The C-terminal carboxylic group of the last amino acid forms a lactone with the hydroxyl of Thr3. Adhesion is the first stage of biofilm formation and the best moment for the action of antiadhesive and anti-biofilm compounds. Adsorption of biosurfactants to a surface e.g. glass, polystyrene, silicone modifies its hydrophobicity, interfering with the microbial adhesion and desorption processes. In this study the role and applications of pseudofactin II as a antiadhesive compound has been investigated from medicinal and therapeutic perspectives. Results Pseudofactin II lowered the adhesion to three types of surfaces (glass, polystyrene and silicone of bacterial strains of five species: Escherichia coli, Enterococcus faecalis, Enterococcus hirae, Staphylococcus epidermidis, Proteus mirabilis and two Candida albicans strains. Pretreatment of a polystyrene surface with 0.5 mg/ml pseudofactin II inhibited bacterial adhesion by 36-90% and that of C. albicans by 92-99%. The same concentration of pseudofactin II dislodged 26-70% of preexisting biofilms grown on previously untreated surfaces. Pseudofactin II also caused a marked inhibition of the initial adhesion of E. faecalis, E. coli, E. hirae and C. albicans strains to silicone urethral catheters. The highest concentration tested (0.5 mg/ml caused a total growth inhibition of S. epidermidis, partial (18-37% inhibition of other bacteria and 8-9% inhibition of C. albicans growth. Conclusion Pseudofactin II showed antiadhesive activity against several pathogenic microorganisms which are potential biofilm formers on catheters, implants and internal

  5. Radiation therapy of benign diseases: patterns of care study in Germany; Strahlentherapie von gutartigen Erkrankungen: eine Bestandsaufnahme fuer Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H. [Alfried Krupp Krankenhaus Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Katalinic, A. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Medizinische Statistik und Dokumentation; Makoski, H.B. [Staedtische Kliniken Duisburg (Germany). Strahlenklinik; Haase, W. [St. Vincentius Krankenhaus Karlsruhe (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Gademann, G. [Magdeburg Univ. (Germany). Klinik fuer Strahlentherapie; Hassenstein, E. [Krankenhaus Nordwest, Frankfurt am Main (Germany). Radioonkologische Klinik

    1999-11-01

    A questionnaire was mailed in 3 years (1994, 1995, 1996) to all radiation facilities in Germany, which assessed equipment, indications, number of patients and treatment concepts. A total of 134 (88%) institutions returned all requested data: 22 in East and 112 in West Germany; 30 in university and 104 in community/private hospitals. The average data of each institution and of all institutions were analyzed for frequencies and ratios between different regions and institutions. A mean of 2 (range 1 to 7) megavoltage (Linac/Cobalt 60) and 1.4 (range 0 to 4) orthovoltage units were available per institution; 32 (24%) institutions had no orthovoltage equipment. A mean of 20,082 patients were treated per year: 456 (2%) for inflammatory diseases (221 hidradenitis, 78 nail bed infection, 23 parotitis, 134 not specified), 12,600 (63%) for degenerative diseases (2,711 peritendinitis humeroscapularis, 1,555 epicondylitis humeri, 1,382 heel spur, 2,434 degenerative osteoarthritis, 4,518 not specified), 927 (5%) for hypertrophic diseases (146 Dupuytren's contracture, 382 keloids, 155 Peyronie's disease, 244 not specified), 1,210 (6%) for functional disorders (853 Graves' orbitopathy, 357 not specified), and 4,889 (24%) for other disorders (e.g. 3,680 heterotopic ossification prophylaxis). In univariate analysis, there were significant geographical (West vs East Germany) differences in the use of radiotherapy for inflammatory and degenerative disorders and institutional differences (university vs community/private hospitals) in the use of radiotherapy for hypertrophic and functional disorders (p<0.05). The prescribed dose concepts were mostly in the low dose range (<10 Gy), but varied widely and inconsistently within geographic regions and institution types. (orig./MG) [German] 1994, 1995 und 1996 wurde an alle strahlentherapeutischen Institutionen in Deutschland ein Fragebogen verschickt, mit dem technische Ausstattung, Indikationsspektrum, Patientenzahl und

  6. Functional characterization of BdB1, a well-conserved carboxylesterase among tephritid fruit flies associated with malathion resistance in Bactrocera dorsalis (Hendel).

    Science.gov (United States)

    Wang, Luo-Luo; Lu, Xue-Ping; Smagghe, Guy; Meng, Li-Wei; Wang, Jin-Jun

    2017-10-01

    There are many evidences that insect carboxylesterase possess important physiological roles in xenobiotic metabolism and are implicated in the detoxification of organophosphate (OP) insecticides. Despite the ongoing resistance development in the oriental fruit fly, Bactrocera dorsalis (Hendel), the molecular basis of carboxylesterase and its ability to confer OP resistance remain largely obscure. This study was initiated to provide a better understanding of carboxylesterase-mediated resistance mechanism in a tephritid pest fly. Here, we narrow this research gap by demonstrating a well-conserved esterase B1 gene, BdB1, mediates malathion resistance development via gene upregulation with the use of a laboratory selected malathion-resistant strain (MR) of B. dorsalis. No sequence mutation of BdB1 was detected between MR and the susceptible strain (MS) of B. dorsalis. BdB1 is predominantly expressed in the midgut, a key insect tissue for detoxification. As compared with transcripts in MS, BdB1 was significantly more abundant in multiple tissues in the MR. RNA interference (RNAi)-mediated knockdown of BdB1 significantly increased malathion susceptibility. Furthermore, heterologous expression along with cytotoxicity assay revealed BdB1 could probably have the function of malathion detoxification. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Epitope mapping and identification of amino acids critical for mouse IgG-binding to linear epitopes on Gly m Bd 28K.

    Science.gov (United States)

    Xi, Jun; Yan, Huili

    2016-10-01

    Gly m Bd 28K is one of the major allergens in soybeans, but there is limited information on its IgG-binding epitopes. Thirty-four overlapping peptides that covered the entire sequence of Gly m Bd 28K were synthesized, and 3 monoclonal antibodies against Gly m Bd 28K were utilized to identify the IgG-binding regions of Gly m Bd 28K. Three dominant peptides corresponding to (28)GDKKSPKSLFLMSNS(42)(G28-S42), (56)LKSHGGRIFYRHMHI(70)(L56-I70), and (154)ETFQSFYIGGGANSH(168)(E154-H168) were recognized. L56-I70 is the most important epitope, and a competitive ELISA indicated that it could inhibit the binding of monoclonal antibody to Gly m Bd 28K protein. Alanine scanning of L56-I70 documented that F64, Y65, and R66 were the critical amino acids of this epitope. Two bioinformatics tools, ABCpred and BepiPred, were used to predict the epitopes of Gly m Bd 28K, and the predictions were compared with the epitopes that we had located by monoclonal antibodies.

  8. Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD and its association with theory of mind (ToM.

    Directory of Open Access Journals (Sweden)

    Agustin Ibanez

    Full Text Available BACKGROUND: Adults with bipolar disorder (BD have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. METHODOLOGY/PRINCIPAL FINDINGS: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP assessment of a dual valence task (DVT, in which faces (angry and happy, words (pleasant and unpleasant, and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word and valence (positive vs. negative. All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word. BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG, including the face fusiform area (FFA. Neural generators of N170 for faces (FG and FFA were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind. CONCLUSIONS/SIGNIFICANCE: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.

  9. 基于GPS\BD2组合的车载导航系统性能分析%Analysis of vehicle navigation performance based on GPS/BD2 integration

    Institute of Scientific and Technical Information of China (English)

    高山; 赵永卿; 谭曦光

    2017-01-01

    The independent development of China’s BeiDou navigation system has already covered the Asia‐Pacific region .To study the performance accuracy of BeiDou system‐based vehicle navigation technology , this paper uses pseudo range single point positioning method to analyze their two‐dimensional positioning accuracy of three navigation modes GPS ,BD2 ,and GPS\\BD2 .The results show that accuracy shows 3.66 m ,4.76 m ,3.01 m ,of w hich the positioning accuracy of BeiDou navigation system based on single point positioning has reached 5 m inside , fully meetting the public daily travel requirements . And compared with GPS navigation system , the combined system has higher precision , so it’ s the best navigation mode .Besides ,writing positioning software based on visual studio platform ,can be used to extract the vehicle position and speed information to monitor w hether the vehicle exceed the speed limit .%中国独立发展的北斗系统已经具备亚太地区的定位导航能力,为研究以北斗系统为主的车载导航技术的应用精度,采用伪距单点定位的方法分别对车载GPS ,BD2,GPS\BD23种导航模式下的二维导航精度进行对比分析,结果显示定位精度分别为:3.66m,4.76m,3.01m,可以看出基于单点定位的北斗二维平面导航精度已达到5m内,完全满足大众日常的出行要求。组合系统与GPS导航系统对比,组合系统具有更高的精度,是较好的导航模式。并基于visual studio平台编写定位软件,实现对车辆位置和速度信息的提取,监控车辆是否超速。

  10. $B_{d} \\to K^{*0}\\mu^{+}\\mu^{-}$ as a lab for discovering new physics at LHCb

    CERN Document Server

    Skottowe, Hugh

    2010-01-01

    The analysis of the penguin decay Bd->K*MuMu at LHCb can act as a laboratory for the discovery and understanding of new physics. Through the Operator Product Expansion, the decay kinematics are well understood in both the Standard Model and in a large range of new physics scenarios. The theoretical errors from QCD effects can be characterized and a set of observables have been derived which minimise their influence in measurements. We will describe how these measurements can be made in LHCb with special emphasis on what can be done with a first run of the LHC with a few hundred pb-1 of integrated luminosity.

  11. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

    DEFF Research Database (Denmark)

    Pitchai, Ganesha P; Hickson, Ian D; Streicher, Werner

    2016-01-01

    Chromosome integrity depends on DNA structure-specific processing complexes that resolve DNA entanglement between sister chromatids. If left unresolved, these entanglements can generate either chromatin bridging or ultrafine DNA bridging in the anaphase of mitosis. These bridge structures...... are defined by the presence of the PICH protein, which interacts with the BEND3 protein in mitosis. To obtain structural insights into PICH-BEND3 complex formation at the atomic level, their respective NTPR and BD1 domains were cloned, overexpressed and crystallized using 1.56 M ammonium sulfate...

  12. Cost management and potential savings in composting. 56th information discussion, Magdeburg, November 1997; Kostenmanagement und Einsparpotentiale bei der Kompostierung. 56. Informationsgespraech in Magdeburg im November 1997

    Energy Technology Data Exchange (ETDEWEB)

    Hangen, H.O. [comp.

    1997-12-31

    This workshop focussed on economic aspects of composting and danaerobic digestion of biological waste. Cost optimisation, methods, and ecological aspects are discussed for several facilities in the Federal Republic of Germany. (SR) [Deutsch] Thema dieses Workshops waren Wirtschaftlichkeitsbetrachtungen auf dem Sektor der Kompostierung und Vergaerung von Bioabfall. Hierbei werden die Kostenoptimierung, verschiedene Verfahren und oekologische Gesichtpunkte am Beispiel verschiedener Anlagen in der Bundesrepublik Deutschland betrachtet. (SR)

  13. Forschung im Ökologischen Landbau: Ist-Zustand und Perspektiven [Research in organic agriculture: Staus Quo and prospects

    OpenAIRE

    Kolbe, Hartmut; Rikabi, Fouad

    2001-01-01

    Im Jahre 1998 wurde das Versuchswesen im Ökologischen Landbau (ÖLB) in der Bundesrepublik Deutschland einer genauen Analyse unterzogen (KOLBE & RIKABI, 2000). Es ging um die Ermittlung des Ist-Zustandes des Versuchswesens durch die Erfassung der verschiedenen Einrichtungen und Organisationsformen in den einzelnen Bundesländern. Neben der Dokumentation der Fächerbreite und der untersuchten Fragestellungen war auch die Aufdeckung von Schwachstellen und Defiziten sowie von zukünftigen Entwicklun...

  14. Managing diversity und gender politics. Theoretische Überlegungen und empirische Untersuchung zum Thema "Frauen und Karriere" am Beispiel von zwei Unternehmensbereichen der Siemens AG.

    OpenAIRE

    Fischer, Eva

    2004-01-01

    Zielsetzung der vorliegenden Arbeit ist es, die Benachteiligung von Frauen in der Wirtschaft zu beleuchten und zu zeigen, ob und wie diese mit dem Konzept „Managing Diversity“ abgebaut werden kann. Die Thematik wurde unter besonderer Berücksichtigung der gesellschaftlichen Rahmenbedingungen der Wissensgesellschaft der Bundesrepublik Deutschland diskutiert. Der Einsatz für die Chancengleichheit von Frauen in Unternehmen wird oft in Anbetracht ökonomisch scheinbar zwingenderer Gründe unterlasse...

  15. Elektrokardiographische Untersuchungen beim Grünen Leguan (Iguana iguana)

    OpenAIRE

    2006-01-01

    Ziel dieser Arbeit war es, neue Erkenntnisse über den bisher wenig beachteten Bereich der elektrokardiographischen Untersuchung in der Reptilienmedizin zu erlangen. Dabei wurden 39 gesunde Grüne Leguane ohne Narkose und 15 gesunde Grüne Leguane in Narkose mit einem Elektrokardiographen für Kleintiere (PC-EKG 2000 der Firma Eickemeyer, Tuttlingen, Bundesrepublik Deutschland) untersucht. Die Tiere wurden zunächst fixiert, dann fand eine Aufzeichnung in Brustlage statt. Die Elektroden wurden ...

  16. Migration und Lebenslauf : Aussiedler im nationalen Wohlfahrtsstaat

    OpenAIRE

    Bommes, Michael

    2000-01-01

    Seit 1989 ist die Migrationspolitik der Bundesrepublik Deutschland generell durch Anstrengungen gekennzeichnet, das Recht von neu ankommenden Migranten auf Zugang und Niederlassung einzuschränken. Der Staat versucht auch, die wohlfahrtsstaatlichen Leistungen für diejenigen Migranten zu beschränken, die wie die deutschstämmigen Aussiedler rechtlich Zugang zu einer permanenten Aufenthaltsberechtigung haben. Der Beitrag analysiert diese makrostrukturellen Veränderungen des Wohlfahrtsstaats und d...

  17. Measurement of the Ratios of Branching Fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) and B(Bs -> Ds pi) / B(Bd -> Dd pi)

    CERN Document Server

    Abulencia, A; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca-Almenar, C; Cuevas-Maestro, J; Culbertson, R; Cully, J C; Cyr, D; D'Auria, S; D'Onofrio, M; Da Ronco, S; Dagenhart, D; Davies, T; De Barbaro, P; De Cecco, S; De Lentdecker, G; De Pedis, D; Deisher, A; Dell'Orso, Mauro; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; Derwent, P F; Di Giovanni, G P; Di Ruzza, B; Di Turo, P; Dionisi, C; Dittmann, J R; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dorr, C; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; García, J E; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Gómez, G; Gómez-Ceballos, G; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Höcker, A; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, S W; Lee, Y J; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; MacQueen, D; Mack, P; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtälä, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mukherjee, A; Mumford, R; Murat, P; Mäki, T; Müller, T; Mülmenstädt, J; Nachtman, J; Nagano, A; Naganoma, J; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Saint-Denis, R; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Sjölin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Sánchez, C; Söderberg, M; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobuev, I P; Volpi, G; Vázquez, F; Wagner, J; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S; Österberg, K

    2006-01-01

    Using 355 pb^-1 of data collected by the CDF II detector in \\ppbar collisions at sqrt{s} = 1.96 TeV at the Fermilab Tevatron, we study the fully reconstructed hadronic decays B -> D pi and B -> D pi pi pi. We present the first measurement of the ratio of branching fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) = 1.05 pm 0.10 (stat) pm 0.22 (syst). We also update our measurement of B(Bs -> Ds pi) / B(Bd -> Dd pi) to 1.13 pm 0.08 (stat) pm 0.23 (syst) improving the statistical uncertainty by more than a factor of two. We find B(Bs -> Ds pi) = [3.8 pm 0.3 (stat) pm 1.3 (syst)] \\times 10^{-3} and B(Bs -> Ds pi pi pi) = [8.4 pm 0.8 (stat) pm 3.2 (syst)] \\times 10^{-3}.

  18. Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii on the fully automated BD MAX platform.

    Science.gov (United States)

    Dalpke, Alexander H; Hofko, Marjeta; Zimmermann, Stefan

    2013-07-01

    Pneumocystis jirovecii is an opportunistic pathogen in immunocompromised and AIDS patients. Detection by quantitative PCR is faster and more sensitive than microscopic diagnosis yet requires specific infrastructure. We adapted a real-time PCR amplifying the major surface glycoprotein (MSG) target from Pneumocystis jirovecii for use on the new BD MAX platform. The assay allowed fully automated DNA extraction and multiplex real-time PCR. The BD MAX assay was evaluated against manual DNA extraction and conventional real-time PCR. The BD MAX was used in the research mode running a multiplex PCR (MSG, internal control, and sample process control). The assay had a detection limit of 10 copies of an MSG-encoding plasmid per PCR that equated to 500 copies/ml in respiratory specimens. We observed accurate quantification of MSG targets over a 7- to 8-log range. Prealiquoting and sealing of the complete PCR reagents in conical tubes allowed easy and convenient handling of the BD MAX PCR. In a retrospective analysis of 54 positive samples, the BD MAX assay showed good quantitative correlation with the reference PCR method (R(2) = 0.82). Cross-contamination was not observed. Prospectively, 278 respiratory samples were analyzed by both molecular assays. The positivity rate overall was 18.3%. The BD MAX assay identified 46 positive samples, compared to 40 by the reference PCR. The BD MAX assay required liquefaction of highly viscous samples with dithiothreitol as the only manual step, thus offering advantages for timely availability of molecular-based detection assays.

  19. Altstadterneuerung in Deutschland

    Directory of Open Access Journals (Sweden)

    Günter Mertins

    2008-01-01

    Full Text Available En forma corta se presentarán inicialmente las razones que llevaron a la renovación de centros históricos en Alemania Occidental (RFA, seguidas de los fundamentos legislativos, de las medidas (sobre todo los aportes financieros públicos y de los resultados al respecto. En este contexto algunos municipios jugaron un papel importante ya que en parte realizaron intensos esfuerzos a través de dichas medidas para la revitalización funcional de sus centros históricos (almacenes especializados, turismo, gentrificación y con ello el fortalecimiento de su fuerza económica. Para finalizar se hace referencia a la renovación de centros históricos en la antigua República Democrática Alemana (RDA después de la reunificación, la que fue además subsidiada en esta parte por los subsidios de la Unión Europea

  20. Situationsanalyse: BPM in Deutschland

    OpenAIRE

    Müller, Sabrina

    2014-01-01

    Die Verbreitung und Entwicklung von Business Process Management (Geschäftsprozessmanagement) ist in den vergangen Jahren, vor allem bei Großunternehmen, schnell und effizient vorangeschritten. Dass es sich hierbei um mehr handelt als einen Hype, erkennt man daran, dass zahlreiche Unternehmen aus den verschiedensten Branchen sich mit diesem Thema beschäftigen. Auf der einen Seite überwiegen im Allgemeinen die Vorteile des BPM gegenüber dem Aufwand und der Kosten, beispielsweise wird die Durchl...

  1. Interkulturelle Kompetenz in der Facharztausbildung von Psychiatern in Deutschland: Ergebnisse einer Umfrage [Intercultural competence in the psychiatric training curriculum in Germany: Results of a survey

    Directory of Open Access Journals (Sweden)

    Machleidt, Wielant

    2008-08-01

    Psychiatrie und Psychotherapie in Deutschland. Methodik: Es wurde ein semistrukturierter Fragebogen mit 30 Fragen (davon 28 strukturiert, 2 mit Freitextangaben entwickelt, der sich an den „Local Survey of Realities in Transcultural Psychiatry“ der (APA anlehnt und für Deutschland modifiziert wurde. Dieser wurde an die Leiter aller psychiatrischen Weiterbildungsinstitutionen in Deutschland verschickt (n=450. Als psychiatrische Weiterbildungsinstitutionen wurden diejenigen klinischen Einrichtungen definiert, deren Leiter über eine Ermächtigung zur Facharztweiterbildung durch die Landesärztekammern verfügen. Der Rücklauf erfolgte nicht anonymisiert. Ergebnisse: Die Rücklaufquote betrug 25,5% (Gesamt-N=114. In 71,7% der Weiterbildungsinstitutionen (n=81/113 gültige Fälle wurden in der klinikinternen Weiterbildung Themen aus dem Gebiet der transkulturellen Psychiatrie selten oder gar nicht angesprochen. 83,3% der Weiterbildungsleiter (n=70/84 gültige Fälle formulierten Bedarf an Weiterbildung in transkultureller Psychiatrie für die jeweils eigene Institution, 94,5% (n=69/73 gültige Fälle sahen den Bedarf grundsätzlich auch für das Curriculum der Facharztausbildung in Psychiatrie und Psychotherapie. Die am häufigsten genannten Themen betrafen eine allgemeine Schulung kultureller Kompetenz sowie kulturspezifische Aspekte seelischer Erkrankungen. Schlussfolgerungen: Im Rahmen der Weiterbildungsordnung zum Facharzt für Psychiatrie und Psychotherapie sind aktuell in keinem Bundesland entsprechende Inhalte aus dem Bereich der transkulturellen Psychiatrie verankert. Angesichts des formulierten Bedarfs muss die Implementierung eines entsprechenden Curriculums in die Weiterbildungsordnung zum Facharzt für Psychiatrie und Psychotherapie diskutiert werden.

  2. Hubble Space Telescope Near-Ultraviolet Spectroscopy of the Bright CEMP-no Star BD+44 493

    CERN Document Server

    Placco, Vinicius; Roederer, Ian; Cowan, John; Frebel, Anna; Filler, Dan; Ivans, Inese I; Lawler, James E; Schatz, Hendrik; Sneden, Christopher; Sobeck, Jennifer; Aoki, Wako; Smith, Verne

    2014-01-01

    We present an elemental-abundance analysis, in the near-ultraviolet (NUV) spectral range, for the extremely metal-poor star BD+44 493, a 9th magnitude sub-giant with [Fe/H] = -3.8 and enhanced carbon, based on data acquired with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. This star is the brightest example of a class of objects that, unlike the great majority of carbon-enhanced metal-poor (CEMP) stars, does not exhibit over-abundances of heavy neutron-capture elements (CEMP-no). In this paper, we validate the abundance determinations for a number of species that were previously studied in the optical region, and obtain strong upper limits for beryllium and boron, as well as for neutron-capture elements from zirconium to platinum, many of which are not accessible from ground-based spectra. The boron upper limit we obtain for BD+44 493, logeps(B) < -0.70, the first such measurement for a CEMP star, is the lowest yet found for very and extremely metal-poor stars. In addition, we ob...

  3. The orbital elements and physical properties of the eclipsing binary BD+36 3317, a probable member of $\\delta$ Lyr cluster

    CERN Document Server

    Kıran, E; Değirmenci, Ö L; Wolf, M; Nemravová, J; Šlechta, M; Koubský, P

    2016-01-01

    Context. The fact that eclipsing binaries belong to a stellar group is useful, because the former can be used to estimate distance and additional properties of the latter, and vice versa. Aims. Our goal is to analyse new spectroscopic observations of BD$+36^\\circ3317$ along with the photometric observations from the literature and, for the first time, to derive all basic physical properties of this binary. We aim to find out whether the binary is indeed a member of the $\\delta$ Lyr open cluster. Methods. The spectra were reduced using the IRAF program and the radial velocities were measured with the program SPEFO. The line spectra of both components were disentangled with the program KOREL and compared to a grid of synthetic spectra. The final combined radial-velocity and photometric solution was obtained with the program PHOEBE. Results. We obtained the following physical elements of BD$+36^\\circ3317$: $M_1 = 2.24\\pm0.07 M_{\\odot}$, $M_2 = 1.52\\pm0.03 M_{\\odot}$, $R_1 = 1.76\\pm0.01 R_{\\odot}$, $R_2 = 1.46\\pm...

  4. Search for Diffuse X-rays from the Bow Shock Region of Runaway Star BD+43$^\\circ$3654 with Suzaku

    CERN Document Server

    Terada, Yukikatsu; Bamba, Aya; Yamazaki, Ryo; Kouzu, Tomomi; Koyama, Shu; Seta, Hiromi

    2012-01-01

    The bow shocks of runaway stars with strong stellar winds of over 2000 km s$^{-1}$ can serve as particle acceleration sites. The conversion from stellar wind luminosity into particle acceleration power has an efficiency of the same order of magnitude as those in supernova remnants, based on the radio emission from the bow shock region of runaway star BD+43$^\\circ$3654 \\citep{Benaglia10}.If this object exhibits typical characteristics, then runaway star systems can contribute a non-negligible fraction of Galactic cosmic-ray electrons. To constrain the maximum energy of accelerated particles from measurements of possible non-thermal emissions in the X-ray band, Suzaku observed BD+43$^\\circ$3654 in April 2011 with an exposure of 99 ks. Because the onboard instruments have a stable and low background level, Suzaku detected a possible enhancement over the background of $7.6\\pm 3.4$ cnt arcmin$^{-2}$ at the bow shock region, where the error represents the 3 sigma statistics only. However, the excess is not signific...

  5. Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop.

    Science.gov (United States)

    Jagodnik, Kathleen M; Koplev, Simon; Jenkins, Sherry L; Ohno-Machado, Lucila; Paten, Benedict; Schurer, Stephan C; Dumontier, Michel; Verborgh, Ruben; Bui, Alex; Ping, Peipei; McKenna, Neil J; Madduri, Ravi; Pillai, Ajay; Ma'ayan, Avi

    2017-07-01

    The volume and diversity of data in biomedical research have been rapidly increasing in recent years. While such data hold significant promise for accelerating discovery, their use entails many challenges including: the need for adequate computational infrastructure, secure processes for data sharing and access, tools that allow researchers to find and integrate diverse datasets, and standardized methods of analysis. These are just some elements of a complex ecosystem that needs to be built to support the rapid accumulation of these data. The NIH Big Data to Knowledge (BD2K) initiative aims to facilitate digitally enabled biomedical research. Within the BD2K framework, the Commons initiative is intended to establish a virtual environment that will facilitate the use, interoperability, and discoverability of shared digital objects used for research. The BD2K Commons Framework Pilots Working Group (CFPWG) was established to clarify goals and work on pilot projects that address existing gaps toward realizing the vision of the BD2K Commons. This report reviews highlights from a two-day meeting involving the BD2K CFPWG to provide insights on trends and considerations in advancing Big Data science for biomedical research in the United States. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Development of renewable energy sources in Germany 2014. Charts and figures based on statistical data from the working group on renewable energy-statistics (AGEE-Stat); Entwicklung der erneuerbaren Energien in Deutschland im Jahr 2014. Grafiken und Diagramme unter Verwendung aktueller Daten der Arbeitsgruppe Erneuerbare Energien-Statistik (AGEE-Stat)

    Energy Technology Data Exchange (ETDEWEB)

    Nieder, Thomas; Bickel, Peter; Musiol, Frank (comps.) [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung Baden-Wuerttemberg (ZSW), Stuttgart (Germany)

    2015-12-15

    The more than 30 diagrams and graphs describe the development of the importance of renewable energy in Germany by the year 2014. Also, discusses the development of avoided greenhouse emissions through renewable energies, as well as the investments and their economic impulses for Germany. Some technical terms are conclusively explained in a glossary. [German] Die mehr als 30 Diagramme und Graphiken beschreiben die Entwicklung der Bedeutung der erneuerbaren Energien fuer Deutschland bis zum Jahr 2014. Auch wird auf die Entwicklung der vermiedenen Treibhaus-Emissionen durch erneuerbare Energien, sowie die Investitionen und deren wirtschaftlichen Impulse fuer Deutschland eingegangen. Einige Fachbegriffe werden abschliessend in einem Glossar erlaeutert.

  7. HBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion.

    Science.gov (United States)

    Kamino, Yoshitaka; Kurashige, Yoshihito; Uehara, Osamu; Sato, Jun; Nishimura, Michiko; Yoshida, Koki; Arakawa, Toshiya; Nagayasu, Hiroki; Saitoh, Masato; Abiko, Yoshihiro

    2014-08-01

    Human β-defensin-2 (hBD-2) is a type of epithelial antimicrobial peptide. The expression level of hBD-2 mRNA is lower in oral carcinoma cells (OCCs) than in healthy oral epithelium. Yet, it is still unknown how hBD-2 expression is downregulated in OCCs. The present study investigated DNA hypermethylation of hBD-2 in OCCs and the effect of the demethylation and increased expression of hBD-2 on cell proliferation and invasion. Six different types of oral carcinoma cell lines (OSC-19, BSC-OF, SAS, HSC-2, HSC-4 and HSY) and normal oral keratinocytes (NOKs) were used. The expression levels of hBD-2 in all OCCs were significantly lower than that in the NOKs. Treatment with DNA methyltransferase inhibitor, 5-aza-dC, at the concentration of 50 µM significantly induced upregulation of expression of hBD-2 in the OCCs. Using methylation-specific PCR, DNA hypermethylation was observed in all OCCs. These results suggest that DNA hypermethylation is, at least in part, involved in the decreased expression of hBD-2 in OCCs. We examined the effect of 5-aza-dC on the cell proliferation and invasive ability of OCCs. The cell invasion assays showed that the number of OCCs treated with 5-aza-dC on the filters was significantly lower than that of the controls. We examined whether increased expression of hBD-2 generated by gene transfection inhibited the proliferation and invasion of SAS cells. The number of SAS cells exhibiting increased expression of hBD-2 on the filters in the invasion assay were significantly lower on day 7 when compared with the control. hBD-2 may function as a tumor suppressor. Increased expression of hBD-2 induced by demethylation or increased expression generated by gene transfection may be useful therapeutic methods for oral carcinoma.

  8. The production of biofuels in Germany. State of the art and optimization approaches; Die Biokraftstoffproduktion in Deutschland. Stand der Technik und Optimierungsansaetze

    Energy Technology Data Exchange (ETDEWEB)

    Braune, Maria; Groengroeft, Arne [DBFZ Deutsches Biomasseforschungszentrum gemeinnuetzige GmbH, Leipzig (Germany); Oehmichen, Katja; Zech, Konstantin

    2015-07-01

    Determining the status quo of existing biofuel plants in Germany, an extensive database of process configurations was received. This information was used to develop simulation models of virtual biofuel plants, which are now available for further investigations. The GHG emissions of biofuels can partly be improved by the studied optimization approaches. The studied optimization approaches can hence contribute to the increasing requirements for GHG reductions of biofuels. The integration of multiple optimization approaches in one concept would improve its GHG balance further. In addition to the investigated technical measures, emissions could also be reduced by adapting the energy supply. The use of biofuels for heat generation, for example, could have an additional reducing effect on total GHG emissions, because a fossil fuel-based heat and electricity supply is the main driver of the GHG balance. From the communication with contacts in the industry it can be said that the German biofuel industry operates production plants that have already reached a high level of efficiency. At many locations, additional measures and modifications are planned, not only driven by economic reasons but also to further improve the GHG balance. The overall results of the project will be published as DBFZ Report No. 22 ''Die Biokraftstoffproduktion in Deutschland - Stand der Technik und Optimierungsansaetze'' in 2015.

  9. Nina Bauer, Jens Luedtke (Hg.: Die soziale Konstruktion von Männlichkeit. Hegemoniale und marginalisierte Männlichkeiten in Deutschland. Opladen u.a.: Verlag Barbara Budrich 2008.

    Directory of Open Access Journals (Sweden)

    Katharina Pühl

    2009-11-01

    Full Text Available Der Band versammelt neuere, vorwiegend empirisch basierte Beiträge aus der Geschlechterforschung der Soziologie. Im Fokus stehen die Konstruktionsprozesse hegemonialer Männlichkeiten im Kontext gesellschaftlicher Transformationsprozesse in Deutschland. Forschungsperspektiven für zukünftige wissenschaftliche Studien werden benannt, allen voran die Notwendigkeit, in einem stärkeren Maße eine intersektionale Perspektive einzunehmen, die die Diskurse der kritischen feministischen Genderforschung noch mehr als bisher für die Männerforschung produktiv machen könnte.The volume collects newer, primarily empirically based articles presenting gender research in sociology. The focus remains on processes of construction of hegemonic masculinities in the context of social processes of transformation in Germany. The volume represents the state of German-language discussions with regard to analysis of masculinities. It identifies research perspectives for future academic studies, especially highlighting the necessity to increasingly include an intersectional perspective that could make the discourses of critical feminist gender research even more productive for masculinity research that currently is the case.

  10. A common variant of staphylococcal cassette chromosome mec type IVa in isolates from Copenhagen, Denmark, is not detected by the BD GeneOhm methicillin-resistant Staphylococcus aureus assay

    DEFF Research Database (Denmark)

    Bartels, Mette Damkjaer; Boye, Kit; Rohde, Susanne Mie

    2009-01-01

    Rapid tests for detection of methicillin-resistant Staphylococcus aureus (MRSA) carriage are important to limit the transmission of MRSA in the health care setting. We evaluated the performance of the BD GeneOhm MRSA real-time PCR assay using a diverse collection of MRSA isolates, mainly from......-specific reagent [ASR] BD GeneOhm MRSA assay) supplied by Becton Dickinson (BD). The ASR BD GeneOhm MRSA assay detected 42 of the 44 isolates that were false negative in the BD GeneOhm MRSA assay. Combining the BD GeneOhm MRSA assay with the ASR BD GeneOhm MRSA assay greatly improved the results, with only two...... MRSA isolates being false negative. The BD GeneOhm MRSA assay alone is not adequate for MRSA detection in Copenhagen, Denmark, as more than one-third of our MRSA isolates would not be detected. We recommend that the BD GeneOhm MRSA assay be evaluated against the local MRSA diversity before being...

  11. Trends and perspectives of raw materials supply in Germany in the 21st millennium. Colloquium 5. Conference report; Trends und Perspektiven der Rohstoffversorgung Deutschlands im 21. Jahrhundert. Kolloquium 5. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    Slaby, D.; Brezinski, H. [comps.] [Technische Univ. Bergakademie Freiberg (Germany). Fakultaet fuer Wirtschaftswissenschaften; Gerhardt, H. [comp.] [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Herzig, P. [comp.] [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Mineralogie

    1999-07-01

    The conference report comprises papers on raw materials policy and management, coal mining in Poland and Czekhia, perspectives of raw materials supply in Germany, mining law and raw materials supply, information systems for regional planning, and the use of washery tailings as construction materials. Ten papers have been recorded separately in the ENERGY database. [German] Der Tagungsband enthaelt Beitraege, die neben der Energierohstoffpolitik, die Rohstoffwirtschaft, den Kohlenbergbau in Polen und Tschechien betreffen. Es werden Perpesktiven der Rohstoffversorgung Deutschlands in der Zukunft sowie Bergrecht und Rohstoffsicherung diskutiert. Weitere Arbeiten betreffen Informationssyteme zur Regionalplannung sowie die Verwertung von Waschbergen als Baustoffersatz. Fuer die Datenbank Energy wurden zehn Beitraege separat aufgenommen.

  12. In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells

    Science.gov (United States)

    Jukosky, James; Gosselin, Benoit J.; Foley, Leah; Dechen, Tenzin; Fiering, Steven; Crane-Godreau, Mardi A.

    2016-01-01

    Smokers and individuals exposed to second-hand cigarette smoke have a higher risk of developing chronic sinus and bronchial infections. This suggests that cigarette smoke (CS) has adverse effects on immune defenses against pathogens. Epithelial cells are important in airway innate immunity and are the first line of defense against infection. Airway epithelial cells not only form a physical barrier but also respond to the presence of microbes by secreting antimicrobials, cytokines, and chemokines. These molecules can lyse infectious microorganisms and/or provide signals critical to the initiation of adaptive immune responses. We examined the effects of CS on antimicrobial secretions of primary human nasal epithelial cells (PHNECs). Compared to non-CS-exposed individuals, PHNEC from in vivo CS-exposed individuals secreted less chemokine ligand (C-C motif) 20 (CCL20), Beta-defensin 1 (BD-1), and SLPI apically, less BD-1 and SLPI basolaterally, and more CCL20 basolaterally. Cigarette smoke extract (CSE) exposure in vitro decreased the apical secretion of CCL20 and beta-defensin 1 by PHNEC from non-CS-exposed individuals. Exposing PHNEC from non-CS exposed to CSE also significantly decreased the levels of many mRNA transcripts that are involved in immune signaling. Our results show that in vivo or in vitro exposure to CS alters the secretion of key antimicrobial peptides from PHNEC, but that in vivo CS exposure is a much more important modifier of antimicrobial peptide secretion. Based on the gene expression data, it appears that CSE disrupts multiple immune signaling pathways in PHNEC. Our results provide mechanistic insight into how CS exposure alters the innate immune response and increases an individual’s susceptibility to pathogen infection. PMID:26793127

  13. BD Phoenix and Vitek 2 detection of mecA-mediated resistance in Staphylococcus aureus with cefoxitin.

    Science.gov (United States)

    Junkins, Alan D; Lockhart, Shawn R; Heilmann, Kristopher P; Dohrn, Cassie L; Von Stein, Diana L; Winokur, Patricia L; Doern, Gary V; Richter, Sandra S

    2009-09-01

    The BD Phoenix (BD Diagnostics, Sparks, MD) and Vitek 2 (bioMérieux, Durham, NC) automated susceptibility testing systems have implemented the use of cefoxitin to enhance the detection of methicillin (meticillin)-resistant Staphylococcus aureus (MRSA). To assess the impact of this change, 620 clinically significant S. aureus isolates were tested in parallel on Phoenix PMIC/ID-102 panels and Vitek 2 AST-GP66 cards. The results for oxacillin and cefoxitin generated by the automated systems were compared to those generated by two reference methods: mecA gene detection and MICs of oxacillin previously determined by broth microdilution according to CLSI guidelines. Testing of isolates with discordant results was repeated to attain a majority or consensus final result. There was 100% final agreement between the results of the two reference methods. For the 448 MRSA and 172 methicillin-susceptible S. aureus isolates tested, the rates of categorical agreement of the results obtained with the automated systems with those obtained by the reference methods were 99.8% for the Phoenix panels and 99.7% for the Vitek 2 cards. A single very major error occurred on each instrument (0.2%) with different MRSA isolates. The only major error was attributed to the Vitek 2 system overcalling oxacillin resistance. In 16 instances (9 on the Phoenix system, 7 on the Vitek 2 system), an oxacillin MIC in the susceptible range was correctly changed to resistant by the expert system on the basis of the cefoxitin result. The inclusion of cefoxitin in the Phoenix and Vitek 2 panels has optimized the detection of MRSA by both systems.

  14. Comparison of BD phoenix to vitek 2, microscan MICroSTREP, and Etest for antimicrobial susceptibility testing of Streptococcus pneumoniae.

    Science.gov (United States)

    Mittman, Scott A; Huard, Richard C; Della-Latta, Phyllis; Whittier, Susan

    2009-11-01

    The performance of the BD Phoenix Automated Microbiology System (BD Diagnostic Systems) was compared to those of the Vitek 2 (bioMérieux), the MicroScan MICroSTREP plus (Siemens), and Etest (bioMérieux) for antibiotic susceptibility tests (AST) of 311 clinical isolates of Streptococcus pneumoniae. The overall essential agreement (EA) between each test system and the reference microdilution broth reference method for S. pneumoniae AST results was >95%. For Phoenix, the EAs of individual antimicrobial agents ranged from 90.4% (clindamycin) to 100% (vancomycin and gatifloxacin). The categorical agreements (CA) of Phoenix, Vitek 2, MicroScan, and Etest for penicillin were 95.5%, 94.2%, 98.7%, and 97.7%, respectively. The overall CA for Phoenix was 99.3% (1 very major error [VME] and 29 minor errors [mEs]), that for Vitek 2 was 98.8% (7 VMEs and 28 mEs), and those for MicroScan and Etest were 99.5% each (19 and 13 mEs, respectively). The average times to results for Phoenix, Vitek 2, and the manual methods were 12.1 h, 9.8 h, and 24 h, respectively. From these data, the Phoenix AST results demonstrated a high degree of agreement with all systems evaluated, although fewer VMEs were observed with the Phoenix than with the Vitek 2. Overall, both automated systems provided reliable AST results for the S. pneumoniae-antibiotic combinations in half the time required for the manual methods, rendering them more suitable for the demands of expedited reporting in the clinical setting.

  15. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.

    Science.gov (United States)

    Araldi, Dioneia; Ferrari, Luiz F; Levine, Jon D

    2016-08-01

    We have recently described a novel form of hyperalgesic priming (type II) induced by agonists at two clinically important Gi-protein-coupled receptors (Gi-GPCRs), mu-opioid and A1-adenosine. Like mu-opioids, the antimigraine triptans, which act at 5-HT1B/D Gi-GPCRs, have been implicated in pain chronification. We determined whether sumatriptan, a prototypical 5-HT1B/D agonist, produces type II priming. Characteristic of hyperalgesic priming, intradermal injection of sumatriptan (10 ng) induced a change in nociceptor function such that a subsequent injection of prostaglandin-E2 (PGE2) induces prolonged mechanical hyperalgesia. However, onset to priming was delayed 3 days, characteristic of type I priming. Also characteristic of type I priming, a protein kinase Cε, but not a protein kinase A inhibitor attenuated the prolongation phase of PGE2 hyperalgesia. The prolongation of PGE2 hyperalgesia was also permanently reversed by intradermal injection of cordycepin, a protein translation inhibitor. Also, hyperalgesic priming did not occur in animals pretreated with pertussis toxin or isolectin B4-positive nociceptor toxin, IB4-saporin. Finally, as observed for other agonists that induce type I priming, sumatriptan did not induce priming in female rats. The prolongation of PGE2 hyperalgesia induced by sumatriptan was partially prevented by coinjection of antagonists for the 5-HT1B and 5-HT1D, but not 5-HT7, serotonin receptors and completely prevented by coadministration of a combination of the 5-HT1B and 5-HT1D antagonists. Moreover, the injection of selective agonists, for 5-HT1B and 5-HT1D receptors, also induced hyperalgesic priming. Our results suggest that sumatriptan, which signals through Gi-GPCRs, induces type I hyperalgesic priming, unlike agonists at other Gi-GPCRs, which induce type II priming.

  16. In vivo cigarette smoke exposure decreases CCL20, SLPI, and BD-1 secretion by human primary nasal epithelial cells.

    Directory of Open Access Journals (Sweden)

    James eJukosky

    2016-01-01

    Full Text Available AbstractSmokers and individuals exposed to second hand cigarette smoke (SHCS have a higher risk of developing chronic sinus and bronchial infections. This suggests that cigarette smoke (CS has adverse effects on immune defenses against pathogens. Epithelial cells are important in airway innate immunity and are the first line of defense against infection. Airway epithelial cells form a physical barrier, but also respond to the presence of microbes by secreting antimicrobials, cytokines and chemokines. These molecules can lyse infectious microorganisms and/or provide signals critical to the initiation of adaptive immune responses. We examined the effects of cigarette smoke on antimicrobial secretions of primary human nasal epithelial cells (PHNEC. Compared to non-CS exposed individuals, PHNEC from in-vivo cigarette smoke exposed individuals secreted less CCL20, BD-1, and SLPI apically, less BD-1 and SLPI basolaterally, and more CCL20 basolaterally. Cigarette smoke extract (CSE exposure in vitro decreased the apical secretion of CCL20 and beta defensin-1 by PHNEC from non-CS exposed individuals. Exposing PHNEC from non-CS exposed to cigarette smoke extract also significantly decreased the levels of many mRNA transcripts that are involved in immune signaling. Our results show that in-vivo or in vitro exposure to cigarette smoke alters the secretion of key antimicrobial peptides from PHNEC, but that in-vivo CS exposure is a much more important modifier of antimicrobial peptide secretion. Based on the gene expression data, it appears that cigarette smoke extract disrupts multiple immune signaling pathways in PHNEC. Our results provide mechanistic insight into how cigarette smoke exposure alters the innate immune response and increases an individual’s susceptibility to pathogen infection.

  17. In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells.

    Science.gov (United States)

    Jukosky, James; Gosselin, Benoit J; Foley, Leah; Dechen, Tenzin; Fiering, Steven; Crane-Godreau, Mardi A

    2015-01-01

    Smokers and individuals exposed to second-hand cigarette smoke have a higher risk of developing chronic sinus and bronchial infections. This suggests that cigarette smoke (CS) has adverse effects on immune defenses against pathogens. Epithelial cells are important in airway innate immunity and are the first line of defense against infection. Airway epithelial cells not only form a physical barrier but also respond to the presence of microbes by secreting antimicrobials, cytokines, and chemokines. These molecules can lyse infectious microorganisms and/or provide signals critical to the initiation of adaptive immune responses. We examined the effects of CS on antimicrobial secretions of primary human nasal epithelial cells (PHNECs). Compared to non-CS-exposed individuals, PHNEC from in vivo CS-exposed individuals secreted less chemokine ligand (C-C motif) 20 (CCL20), Beta-defensin 1 (BD-1), and SLPI apically, less BD-1 and SLPI basolaterally, and more CCL20 basolaterally. Cigarette smoke extract (CSE) exposure in vitro decreased the apical secretion of CCL20 and beta-defensin 1 by PHNEC from non-CS-exposed individuals. Exposing PHNEC from non-CS exposed to CSE also significantly decreased the levels of many mRNA transcripts that are involved in immune signaling. Our results show that in vivo or in vitro exposure to CS alters the secretion of key antimicrobial peptides from PHNEC, but that in vivo CS exposure is a much more important modifier of antimicrobial peptide secretion. Based on the gene expression data, it appears that CSE disrupts multiple immune signaling pathways in PHNEC. Our results provide mechanistic insight into how CS exposure alters the innate immune response and increases an individual's susceptibility to pathogen infection.

  18. 重组人BD3-BPI的内毒素中和活性及其在高盐环境中抗菌活性的稳定性%LPS Neutralization Activity and High-Salt Sensitivity of rhBD3-BPI

    Institute of Scientific and Technical Information of China (English)

    庹晓晔; 蒋伟; 李杰之; 柴家科; 郭希民

    2013-01-01

    Objective: To study the lipopolysaacharide(LPS) neutralization activity and high-salt sensitivity of rh-BD3-BPI, a recombinant human β-defensin 3(hBD3) and bactericidal permeability-increasing protein(BPI) fusion protein. Methods: Standard curve of LPS activity was created using Limulus Amebocyte Lasate test based on stan-dard LPS product. 100 μL serially diluted rhBD3-BPI was mixed with 100 μL 10 EU/mL LPS and incubated in water for 60 minutes at 37℃. 10 EU/mL LPS served as control and water served as blank control. 6×108 CFU/mL standard or clinically isolated wild Gram-positive or -negative bacterial strains were incubated at 37℃ for 3 h in 1 mg/mL rhBD3-BPI supplemented with 0~250 mmol/L of NaCl and then diluted at ratios from 1∶1 to 1∶1000 with 10 mmol/L sodium phosphate. 50 μL cells were plated in LB agar gel and incubated overnight, numbers of bacterial colonies were counted and bactericide rate was calculated. Results: In 5 EU/mL LPS system, LPS activi-ty neutralization was detected when rhBD3-BPI was above 4 μg/mL, 23% and 88% LPS neutralization rates were reached when rhBD3-BPI was 16 and 32 μg/mL, respectively. 50 μg/mL rhBD3-BPI had a 100% bactericidal ef-fect on all the strains. This effect was not influenced by increasing NaCl concentration before reaching 150 mmol/L. When the concentration of NaCl reached 200 mmol/L, the bactericidal effect remained above 90%. Significant decrease only appeared when the concentration of NaCl was above 200 mmol/L, however, the bactericidal effect of rhBD3- BPI remained above 85% even at the NaCl concentration of 250 mmol/L. Conclusion: rhBD3-BPI can neutralize LPS and has a stable bactericidal activity in high-salt solutions.%目的:验证重组人BD3-BPI(rhBD3-BPI)是否具有内毒素中和活性,研究其在高盐环境中是否能保持抗菌活性。方法:根据内毒素标准品绘制内毒素活性标准曲线,将100μL梯度稀释的rhBD3-BPI与100μL 10 EU

  19. Comparison of Chromogenic Media to BD GeneOhm Methicillin-Resistant Staphylococcus aureus (MRSA) PCR for Detection of MRSA in Nasal Swabs▿

    OpenAIRE

    Bischof, Larry J.; Lapsley, Linda; Fontecchio, Karen; Jacosalem, Dollie; Young, Carol; Hankerd, Rosemary; Newton, Duane W.

    2009-01-01

    To select a method for detecting methicillin-resistant Staphylococcus aureus (MRSA) in nasal swabs, we compared BD GeneOhm MRSA PCR and various culture media (mannitol salt agar with cefoxitin, MRSASelect, CHROMagar MRSA, and Spectra MRSA). While PCR detection of MRSA was more rapid, MRSASelect and Spectra MRSA demonstrated performance equivalent to that of PCR with maximal detection at 24 h.

  20. Expression of hBD-2 induced by 23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae type b vaccine and split influenza virus vaccine.

    Science.gov (United States)

    Shen, Zhenwei; Lei, Han

    2012-10-01

    Human β-defensin-2 (hBD-2) is an antimicrobial peptide with high activity and broad spectrum activity. hBD-2 expression may be highly elevated by microorganisms and inflammation. We reported that the majority of common vaccines used, including 23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae type b vaccine and split influenza virus vaccine, could induce the expression of hBD-2 in epithelial cells. Among them, the 23-valent pneumococcal polysaccharide vaccine was effective at a lower concentration (0.5 µg/ml), while Haemophilus influenzae type b vaccine and split influenza virus vaccine were effective at the concentration of 1 µg/ml. However, bacteriostatic experiments revealed that the split influenza virus vaccine was capable of inducing the highest antimicrobial activity. The medium of the 23-valent pneumococcal polysaccharide vaccine treatment group had a higher antimicrobial activity than the medium of the Haemophilus influenzae type b vaccine treatment group. The transcriptional regulator of hBD-2, that is, the NF-κB subunit, had a high level of activity, while the normal epithelial cells showed barely detectable activity, indicating that these vaccines have potential for clinical application.

  1. A dual mechanism involved in membrane and nucleic acid disruption of AvBD103b, a new avian defensin from the king penguin, against Salmonella enteritidis CVCC3377.

    Science.gov (United States)

    Teng, Da; Wang, Xiumin; Xi, Di; Mao, Ruoyu; Zhang, Yong; Guan, Qingfeng; Zhang, Jun; Wang, Jianhua

    2014-10-01

    The food-borne bacterial gastrointestinal infection is a serious public health threat. Defensins are evolutionarily conserved innate immune components with broad-spectrum antibacterial activity that do not easily induce resistance. AvBD103b, an avian defensin with potent activity against Salmonella enteritidis, was isolated from the stomach contents of the king penguin (Aptenodytes patagonicus). To elucidate further the antibacterial mechanism of AvBD103b, its effect on the S. enteritidis CVCC3377 cell membrane and intracellular DNA was researched. The cell surface hydrophobicity and a N-phenyl-1-naphthylamine uptake assay demonstrated that AvBD103b treatment increased the cell surface hydrophobicity and outer membrane permeability. Atomic absorption spectrometry, ultraviolet spectrophotometry, flow cytometry, and transmission electron microscopy (TEM) indicated that AvBD103b treatment can lead to the release of the cellular contents and cell death through damage of the membrane. DNA gel retardation and circular dichroism analysis demonstrated that AvBD103b interacted with DNA and intercalated into the DNA base pairs. A cell cycle assay demonstrated that AvBD103b affected cellular functions, such as DNA synthesis. Our results confirmed that AvBD103b exerts its antibacterial activity by damaging the cell membrane and interfering with intracellular DNA, ultimately causing cell death, and suggested that AvBD103b may be a promising candidate as an alternative to antibiotics against S. enteritidis.

  2. Increase in medical knowledge during the final year of undergraduate medical education in Germany [Wissenszuwachs im Praktischen Jahr des Medizinstudiums in Deutschland

    Directory of Open Access Journals (Sweden)

    Harendza, Sigrid

    2013-08-01

    Full Text Available [english] Aims: In Germany, the final year of undergraduate medical education (‘practice year’ consists of three 16-week clinical attachments, two of which are internal medicine and surgery. Students can choose a specific specialty for their third 16-week attachment. Practice year students do not receive specific teaching to prepare them for the National Licensing Examination. It is unknown whether knowledge levels increase during this year. This study aimed at assessing knowledge at the beginning and the end of the final year of medical school. Methods: Three hundred pre-selected United States Medical Licensing Examination type items from ten medical disciplines were reviewed by ten recent medical graduates from the Netherlands and Germany. The resulting test included 150 items and was taken by 77 and 79 final year medical students from Göttingen and Hamburg at the beginning and the end of their practice year, respectively. Results: Cronbach’s α of the pre- and post-test was 0.75 and 0.68, respectively. Mean percent scores in the pre- and post-test were 63.9±6.9 and 69.4±5.7, respectively (p[german] Zielsetzung: In Deutschland besteht das letzte Jahr des Studiums der Humanmedizin ("Praktisches Jahr", PJ aus drei Tertialen von je 16 Wochen, von denen eines in der Inneren Medizin und eines in der Chirurgie abzuleisten ist. Die Fachrichtung des dritten Tertials von 16 Wochen kann von den Studierenden frei gewählt werden. Während des Praktischen Jahres findet keine gezielte Vorbereitung auf den schriftlichen Teil des Staatsexamens statt. Es ist unklar, inwieweit die Studierenden während des Praktischen Jahres auch neue Wissensinhalte erlernen. Ziel dieser Studie war es, zu Beginn und am Ende des Praktischen Jahres Wissensinhalte zu überprüfen. Methodik: Zehn Absolventen des Medizinstudiums in Deutschland und den Niederlanden trafen eine Auswahl aus 300 vorselektierten Fragen der US-amerikanischen Abschlussprüfung (USMLE, die zehn

  3. Database study of lenalidomide (Revlimid in Germany: monitoring off-label use [Monitoring des Off-Label-Use von Lenalidomid (Revlimid in Deutschland

    Directory of Open Access Journals (Sweden)

    Dörks, Michael

    2013-07-01

    Full Text Available [english] Background: Lenalidomide, a derivate of thalidomide, in combination with dexamethasone is indicated for the treatment of multiple myeloma in patients who have received at least one prior therapy. In the USA, lenalidomide is also licensed for the treatment of a certain form of myelodysplastic syndromes (MDS. Monitoring of off-label use in Germany is part of the risk management plan mandated by the regulatory authority. Material and methods: Our retrospective epidemiological study was based on claims data of the year 2007 from four statutory health insurances with more than 14 million enrollees. Annual incidence was calculated by dividing the total number of new lenalidomide users by the sum of person-years of the at-risk population. Potential off-label use was identified by an algorithm searching for a diagnosis of multiple myeloma in the quarter of the lenalidomide prescription and the four preceding quarters. Results: In 2007, 235 lenalidomide users were identified. Incidence of lenalidomide use was 4.0 per 100,000 person years (95% CI: 3.5–4.5. In 40 (17.0% users of lenalidomide, no diagnosis of multiple myeloma was found. Of the 40 off-label users, 29 (72.5% had a diagnosis of MDS. Conclusion: Off-label use of lenalidomide in Germany was low and mainly related to MDS.[german] Hintergrund: Lenalidomid, ein Derivat des Thalidomids, ist in Kombination mit Dexamethason indiziert für die Behandlung des multiplen Myeloms bei Patienten, die mindestens eine vorausgegengene Therapie erhalten haben. In den USA ist Lenalidomid zudem zur Behandlung einer Form des Myelodysplastischen Syndroms (MDS zugelassen. Die Untersuchung des Off-Label-Uses in Deutschland ist Teil eines behördlich geforderten Risikomanagementplanes.Material und Methoden: Im Rahmen einer retrospektiven epidemiologischen Studie wurden Abrechnungsdaten des Jahres 2007 von vier gesetzlichen Krankenkassen mit mehr als 14 Millionen Versicherten analysiert. Die Inzidenz von

  4. Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.

    Science.gov (United States)

    Yoon, Seo-Yeon; Kang, Suk-Yun; Kim, Hyun-Woo; Kim, Hyung-Chan; Roh, Dae-Hyun

    2015-01-01

    Although the administration of clonidine, an alpha-2 adrenoceptor agonist, significantly attenuates nociception and hyperalgesia in several pain models, clinical trials of clonidine are limited by its side effects such as drowsiness, hypotension and sedation. Recently, we determined that the sigma-1 receptor antagonist BD1047 dose-dependently reduced nociceptive responses in a mouse orofacial formalin model. Here we examined whether intraperitoneal injection of clonidine suppressed the nociceptive responses in the orofacial formalin test, and whether co-administration with BD1047 enhances lower-dose clonidine-induced anti-nociceptive effects without the disruption of motor coordination and blood pressure. Formalin (5%, 10 µL) was subcutaneously injected into the right upper lip, and the rubbing responses with the ipsilateral fore- or hind-paw were counted for 45 min. Clonidine (10, 30 or 100 µg/kg) was intraperitoneally administered 30 min before formalin injection. Clonidine alone dose-dependently reduced nociceptive responses in both the first and second phases. Co-localization for alpha-2A adrenoceptors and sigma-1 receptors was determined in trigeminal ganglion cells. Interestingly, the sub-effective dose of BD1047 (3 mg/kg) significantly potentiated the anti-nociceptive effect of lower-dose clonidine (10 or 30 µg/kg) in the second phase. In particular, the middle dose of clonidine (30 µg/kg) in combination with BD1047 produced an anti-nociceptive effect similar to that of the high-dose clonidine, but without a significant motor dysfunction or hypotension. In contrast, mice treated with the high dose of clonidine developed severe impairment in motor coordination and blood pressure. These data suggest that a combination of low-dose clonidine with BD1047 may be a novel and safe therapeutic strategy for orofacial pain management.

  5. Repair of Staphylococcus aureus-infected wound with gene-modified C3H10T1/2 cells expressing BPI-BD3 fusion antibiotic peptide

    Directory of Open Access Journals (Sweden)

    Xin-ran ZHANG

    2015-10-01

    Full Text Available Objective To study the antibacterial and tissue reparative effect of BPI-BD3 gene-modified mesenchymal stem cells in a mouse model of wound infection. Methods C3H10T1/2 cells were transfected with recombinant adenovirus vector pAdxsi-BPI-BD3, the expression of BPI-BD3 fusion protein was verified by RT-PCR and Western blotting. Excision wound with a diameter of 1cm was inoculated with Staphylococcus aureuswas made on the back of 30 mice. The mice were randomly divided into 3 groups (10 each. Mice in group T were injected with BPI-BD3 gene-modified C3H10T1/2 cells through caudal vein, those in group C were injected with unmodified C3H10T1/2 cells, and in group N were injected with PBS as control. The wound repair result was evaluated by estimation of the percentage of remaining wound area and the amount of wound bacteria under the scar, followed by observation of pathological changes. Inflammatory reactions of the wounds were assessed accordingly. Results The amount of bacteria under the scar was less in group T than in the other two groups (P<0.05. It was also found that the wound healing process was faster in group T than in group C and group N. Pathological observation showed that the inflammatory reaction in group T was also significantly milder than in the other two groups. Conclusion BPI-BD3 gene-modified mesenchymal stem cells may enhance wound repair by controlling infection and promoting tissue regeneration, thus it may be promising in clinical application. DOI: 10.11855/j.issn.0577-7402.2015.09.07

  6. Evaluation of the BD MAX Enteric Parasite Panel for the detection of Cryptosporidium parvum/hominis, Giardia duodenalis and Entamoeba histolytica.

    Science.gov (United States)

    Perry, Michael D; Corden, Sally A; Lewis White, P

    2017-08-01

    Conventional laboratory detection methods for gastrointestinal parasites are time consuming, require considerable technical expertise and may suffer from poor analytical sensitivity. This study sought to evaluate the automated BD MAX Enteric Parasite Panel (EPP) for the detection of Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia duodenalis.Methodolgy. A total of 104 known positive samples (43 Cryptosporidium parvum/hominis and 61 G. duodenalis), 15 simulated samples (E. histolytica and other Entamoeba species) and 745 patient stool samples, submitted for enteric pathogen culture and microscopy, were inoculated into BD MAX EPP sample buffer tubes (SBTs). All specimens were blinded and tested within 7 days of SBT inoculation using the BD MAX EPP assay with results compared to those generated by microscopy.Results/Key findings. Combining the results from the known positive samples and anonymously tested patient samples, the sensitivity of the BD MAX EPP assay was 100 % for both Cryptosporidium spp. and G. duodenalis. Specificities of 99.7 and 98.9 % were calculated for the detection of Cryptosporidium spp. and G. duodenalis respectively. Insufficient clinical specimen data was available to determine the performance of the assay for E. histolytica detection. The findings of this study indicate that the BD MAX EPP is suitable for the detection of Cryptosporidium parvum/hominis and G. duodenalis from clinical specimens with reduced hands-on time and complexity compared to microscopy. Results for the detection of E. histolytica were promising although further work is required to evaluate the assay for the detection of this pathogen.

  7. Modularer studienbegleitender Deutschunterricht zur Vorbereitung auf Studium und Praktikum in Deutschland am Beispiel der German-Jordanian University in Amman, Jordanien

    Directory of Open Access Journals (Sweden)

    Michael de Jong

    2015-04-01

    Full Text Available Die German-Jordanian University (GJU ist eine staatliche Hochschule in Amman, Jordanien, die durch das Bundesministerium für Bildung und Forschung (BMBF und den Deutschen Akademischen Austauschdienst (DAAD gefördert wird. Gegründet im Jahr 2005, ist es noch eine sehr junge Universität. Ihr Alleinstellungsmerkmal ist das verpflichtende vierte Studienjahr in Deutschland, in dem jeder Studierende ein Semester an einer deutschen Partnerhochschule und ein weiteres in einem Praktikum verbringt. In den ersten drei Jahren ihres Studiums müssen alle Studieren­den sechs Stufen Deutsch in einem maßgeschneiderten Programm des German Language Centers absolvieren. Der vorliegende Artikel skizziert die Strukturen des Zentrums, beschreibt den modulbasierten Deutschunterricht und diskutiert die Herausforderungen eines der größten German Language Center weltweit.   The German-Jordanian University (GJU is a public institution of higher education located in Amman, Jordan, funded by the German Federal Ministry of Education and Research (BMBF and the German Academic Exchange Service (DAAD. Founded in 2005, it is still a very young university. Its unique selling proposition is the compulsory 4th year in Germany, during which every student spends one semester at a partner university and a second semester doing an internship. In the first three years of their studies, all students have to pass six levels of German in a tailor-made program provided by the German Language Center. This article outlines the structure of the center, describes the module-based German language tuition and discusses the challenges faced by one of the biggest German Language Centers in the world.

  8. La música gráfica de León Schidlowsky: Deutschland, ein Wintermárchen (1979 como partitura multimedial The Graphic Music of León Schidlowsky: Deutschland, ein Wintermárchen (1979 as a Multimedia Score

    Directory of Open Access Journals (Sweden)

    Daniela Fugellie Videla

    2012-12-01

    Full Text Available Este estudio aborda la música gráfica de León Schidlowsky (n. 1931, un género que el compositor cultivara mayoritariamente entre los años 1969 y 1984, inmediatamente tras su emigración desde Israel. Su propósito es presentar un panorama general del desarrollo del lenguaje gráfico del compositor y analizar algunos aspectos específicos de su obra Deutschland, ein Wintermárchen (1979, considerada por la autora como un punto culminante de dicho desarrollo. La investigación destaca la concepción multimedial de la obra, derivada de la técnica del collage, la cual logra sintetizar los diversos aspectos musicales, visuales y performativos, para obtener una visualización simultánea de un arte esencialmente temporal. Asimismo, el estudio profundiza en el contenido social y político de la obra. Postula finalmente que esta concepción heterogénea y multifacética es propia de un compositor transcultural, que transita libremente entre culturas y estéticas diversas.This paper deals with the graphic music ofLeón Schidlowsky (b.1931, a genre cultivated by the composermostly from 1969to 1984 afteremigratingfrom Chile to Israel. It presents a generalpanorama ofthe development ofthe graphical language ofthe composer, and analyzes some specific features of his work Deutschland, ein Wintermárchen (1979, considered by the author ofthe article as a culminating point of Schidlowsky's creative development. The research underlines the conception ofthis work as multimedia derived from the collage technique synthesizing the different musical, visual and performative aspects ofthe work into a simultaneous visualization ofwhat amounts to be an essentially temporal art. Besides, the study explores the social and political contents ofthe work, to conclude that this heterogeneous and multifarious conception is a natural feature of a transcultural composer, who moves freely among diverse cultures and aesthetics.

  9. Determinants of the distribution and concentration of biogas production in Germany. A spatial econometric analysis; Bestimmungsfaktoren der Verteilung und Konzentration der Biogasproduktion in Deutschland. Eine raeumlich-oekonometrische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, Lukas

    2015-07-01

    The biogas production in Germany is characterized by a heterogeneous distribution and the formation of regional centers. In the present study the determinants of the spatial distribution and concentration are analyzed with methods of spatial statistics and spatial econometrics. In addition to the consideration of ''classic'' site factors of agricultural production, the analysis here focuses on the possible relevance of agglomeration effects. The results of the work contribute to a better understanding of the regional distribution and concentration of the biogas production in Germany. [German] Die Biogasproduktion in Deutschland ist durch eine heterogene Verteilung und die Ausbildung von regionalen Zentren charakterisiert. In der vorliegenden Arbeit werden die Bestimmungsfaktoren der raeumlichen Verteilung und Konzentration mit Methoden der raeumlichen Statistik und der raeumlichen Oekonometrie analysiert. Neben der Betrachtung ''klassischer'' Standortfaktoren landwirtschaftlicher Produktion fokussiert die Analyse dabei auf die moegliche Relevanz von Agglomerationseffekten. Die Ergebnisse der Arbeit tragen zu einem besseren Verstaendnis der regionalen Verteilung und Konzentration der Biogasproduktion in Deutschland bei.

  10. Palliativmedizinische Lehre in Deutschland – Planungen der Fakultäten zum zukünftigen Querschnittsfach 13 [Palliative Care teaching in Germany – concepts and future developments

    Directory of Open Access Journals (Sweden)

    Ilse, B.

    2012-05-01

    higher degree of mandatory teaching in alignment with the requirements of the ÄApprO. A broad spectrum of educationally-involved occupational groups, specialist disciplines and external co-operating partners, were mentioned. Conclusion: The infrastructural prerequisites of the present curricular concepts and the degree of implementation of the Q13 according to the requirements of the new ÄApprO diverge significantly among the various medical faculties. The efforts made to produce a qualitatively high standard of teaching with regard to the multifaceted questions concerning the support for severely and terminally ill patients is as much reflected in the survey, as the special implications of an independent Chair for palliative medicine for the implementation of the requirements by law. The participation of various occupational groups in this survey as well as the broad spectrum of those involved highlights the interdisciplinary and multi-professional dimension of teaching in palliative care. [german] Fragestellung: Mit der Änderung der ärztlichen Approbationsordnung (ÄApprO im Jahre 2009 wurde die Palliativmedizin als 13. Querschnittsfach (Q13 verpflichtend in das studentische Curriculum eingeführt. Die Umsetzung dieser Änderung muss bis zum Beginn des Praktischen Jahres im August 2013 oder bei der Meldung zum Zweiten Abschnitt der Ärztlichen Prüfung für den Prüfungstermin im Oktober 2014 erfolgen.In vorangegangenen Umfragen wurden an den medizinischen Fakultäten in Deutschland sehr heterogene palliativmedizinische Lehrstrukturen beschrieben. Daher sollten nun die curricularen und prüfungsbezogenen Planungen der jeweiligen Fakultäten zur Implementierung eines verpflichtenden Q13 Palliativmedizin erfragt werden.Methodik: Die Bundesvertretung der Medizinstudierenden Deutschlands (bvmd führt seit 2006 zweijährliche Umfragen an allen medizinischen Fakultäten in Deutschland zum gegenwärtigen Stand der palliativmedizinischen Lehre durch.Nach Konzeption eines

  11. BD PHOENIX-100全自动微生物鉴定仪对葡萄球菌鉴定能力的评价%Evaluation of the BD PHOENIX-100 Automated Microbiology System for Identification of Staphylococcus

    Institute of Scientific and Technical Information of China (English)

    王原; 曹俊敏; 陈益民; 许江燕

    2009-01-01

    [目的]评价BD PHOENIX-100全自动微生物鉴定仪(PHOENIX-100)对葡萄球菌的鉴定能力.[方法]收集从我院病人标本中分离的葡萄球菌81株.常规细菌培养后,用PHOENIX-100和API Staph系统进行检测,以API Staph系统为参照,评价PHOENIX-100的优势和不足.[结果]PHOENIX-100和API Staph系统的总体鉴定符合率为86.4%,其中金黄色葡萄球菌的鉴定符合率为100%,凝固酶阴性葡萄球菌的鉴定符合率为73.8%.[结论]PHOENIX-100鉴定系统能够基本满足临床工作的需求,其中对金黄色葡萄球菌的鉴定率较高,在进行凝固酶阴性葡萄球菌鉴定时有局限性.

  12. Low temperature Raman spectroscopy of Mg(BH{sub 4}){sub 2} and Mg(BD{sub 4}){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Gebert, Florian; Willenberg, Britta; Schoenes, Joachim [Institut fuer Physik der Kondensierten Materie, TU Braunschweig (Germany); Setten, Michiel van; Frommen, Christoph; Fichtner, Maximilian [Institute of Nanotechnology, Forschungszentrum Karlsruhe (Germany)

    2009-07-01

    We report a micro-Raman scattering study on fine powders of Mg(BH{sub 4}){sub 2} and Mg(BD{sub 4}){sub 2} for temperatures ranging from approximately 5K to room temperature. At the lowest temperature, we observe 25 lines in both compounds, which were assigned within the 86 Raman active modes, for the I-4m2 structure, whose energies have been derived using first principle calculations based on density functional theory. This structure was claimed by Ozolins et al. to posses an even lower ground state energy than the P6{sub 1} structure reported formerly for the low temperature {alpha}-phase. The comparison of theoretical and experimental values leads to straight lines with slopes between 0.98 and 1.03 for the external, bending and stretching modes, which is better than expected. Nevertheless, one can not definitively conclude that the structure is I-4m2 since a substantial number of possible lines have not been observed. This is even more so for the P6{sub 1} structure. Further progress will require measurements on single crystals and/or intensity computations.

  13. The kinetics, current efficiency, and power consumption of electrochemical dye decolorization by BD-NCD film electrode

    Science.gov (United States)

    Nurhayati, Ervin; Juang, Yaju; Huang, Chihpin

    2017-06-01

    Diamond film electrode has been known as a material with very wide potential window for water electrolysis which leads to its applicability in numerous electrochemical processes. Its capability to produce hydroxyl radicals, a very strong oxidants, prompts its popular application in wastewater treatment. Batch and batch recirculation reactor were applied to perform bulk electrolysis experiments to investigate the kinetics of dye decolorization under different operation conditions, such as pH, active species, and current density. Furthermore, COD degradation data from batch recirculation reactor operation was used as the basis for the calculation of current efficiency and power consumption in the decolorization process. The kinetics of decolorization process using boron-doped nanocrystalline diamond (BD-NCD) film electrode revealed that acidic condition is favored for the dye degradation, and the presence of chloride ion in the solution was found to be more advantageous than sulfate active species, as evidenced by the higher reaction rate constants. Applying different current density of 10, 20 and 30 mA cm-2, it was found that the higher the current density the faster the decolorization rate. General current efficiency achieved after nearly total decolorization and 80% COD removal in batch recirculation reactor was around 74%, with specific power consumption of 4.4 kWh m-3 (in terms of volume of solution treated) or 145 kWh kg-1(in terms of kg COD treated).

  14. Studies of RICH detectors and the $B_d \\rightarrow K^{*}\\mu^{+}\\mu^{-}$ decay at the LHCb experiment

    CERN Document Server

    Skottowe, Hugh Philip

    2010-01-01

    LHCb is an experiment designed for precise studies of the large number of b-hadrons expected at the Large Hadron Collider. This thesis first introduces the Standard Model of Particle Physics and motivates the LHCb experiment. The design of the LHCb forward spectrometer is then described, including performance of the detector with recent LHC collisions. The ring imaging Cherenkov (RICH) sub-detector is described in particular detail. This uses three radiators to identify particles over the momentum range 1-100 GeV/c. Tests performed of an LHCb RICH prototype with a charged pion beam are described in detail. Excellent performance is found in agreement with that expected from studies of simulated data. The decay $B_d \\rightarrow K^{*}\\mu^{+}\\mu^{-}$ is a powerful indirect probe of new physics. In particular, the forward-backward asymmetry of the muon pair is precisely predicted in the Standard Model and many new physics models, and measurements of this asymmetry will discriminate between the widely varying expec...

  15. TRUMP-BD: A computer code for the analysis of nuclear fuel assemblies under severe accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Lombardo, N.J.; Marseille, T.J.; White, M.D.; Lowery, P.S.

    1990-06-01

    TRUMP-BD (Boil Down) is an extension of the TRUMP (Edwards 1972) computer program for the analysis of nuclear fuel assemblies under severe accident conditions. This extension allows prediction of the heat transfer rates, metal-water oxidation rates, fission product release rates, steam generation and consumption rates, and temperature distributions for nuclear fuel assemblies under core uncovery conditions. The heat transfer processes include conduction in solid structures, convection across fluid-solid boundaries, and radiation between interacting surfaces. Metal-water reaction kinetics are modeled with empirical relationships to predict the oxidation rates of steam-exposed Zircaloy and uranium metal. The metal-water oxidation models are parabolic in form with an Arrhenius temperature dependence. Uranium oxidation begins when fuel cladding failure occurs; Zircaloy oxidation occurs continuously at temperatures above 13000{degree}F when metal and steam are available. From the metal-water reactions, the hydrogen generation rate, total hydrogen release, and temporal and spatial distribution of oxide formations are computed. Consumption of steam from the oxidation reactions and the effect of hydrogen on the coolant properties is modeled for independent coolant flow channels. Fission product release from exposed uranium metal Zircaloy-clad fuel is modeled using empirical time and temperature relationships that consider the release to be subject to oxidation and volitization/diffusion ( bake-out'') release mechanisms. Release of the volatile species of iodine (I), tellurium (Te), cesium (Ce), ruthenium (Ru), strontium (Sr), zirconium (Zr), cerium (Cr), and barium (Ba) from uranium metal fuel may be modeled.

  16. Analysis of combined radial velocities and activity of BD+20 1790: evidence supporting the existence of a planetary companion

    CERN Document Server

    Hernán-Obispo, M; Gálvez-Ortiz, M C; Golovin, A; Barnes, J R; Jones, H R A; Kane, S R; Pinfield, D; Jenkins, J S; Petit, P; Anglada-Escudé, G; Marsden, S C; Catalán, S; Jeffers, S V; de Castro, E; Cornide, M; Garcés, A; Jones, M I; Gorlova, N; Andreev, M

    2015-01-01

    This paper presents the simultaneous Bayesian analysis of the radial velocity and activity indices for the K5Ve active star BD+20 1790, that was proposed to host a close-in massive planet by Hern\\'an-Obispo et al. (2010). The Bayesian analysis supports the hypothesis of a planetary companion. We present a new orbital solution after removing the two main contributions to the stellar jitter, one that varies with the photometric period and another that varies with the synodic period of the star+planet system. We use a new method to determine these jitter components, considering them as a second and third signals in the system. A discussion on possible magnetic star-planet-interaction is included, based on the Bayesian analysis of the activity indices. We propose two possible sources for flare events of this star: one related to the geometry of the system and the relative movement of the star+planet, and a second one purely stochastic source that is related to the evolution of stellar active regions. Also, we obs...

  17. Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression.

    Science.gov (United States)

    Ghaemi, S Nassir

    2008-12-01

    The widely held clinical view of 'antidepressants' as highly effective and specific for the treatment of all types of depressive disorders is exaggerated. This sobering conclusion is supported by recent findings from the NIMH-sponsored STEP-BD and STAR*D projects. Antidepressants have limited short-term efficacy in unipolar depressive disorders and less in acute bipolar depression; their long-term prophylactic effectiveness in recurrent unipolar major depression remains uncertain, and is doubtful in recurrent bipolar depression. These limitations may, in part, reflect the excessively broad concept of major depression as well as unrealistic expectations of universal efficacy of drugs considered 'antidepressants.' Treatment-refractory depression may reflect failure to distinguish depressive conditions, particularly bipolar disorder, that are inherently less responsive to antidepressants. Antidepressants probably should be avoided in bipolar depression, mixed manic-depressive states, and in neurotic depression. Expectations of antidepressants for specific types of patients with symptoms of depression or anxiety require critical re-evaluation. A revival of the concept of neurotic depression would make it possible to identify patients with mild-to-moderate, chronic or episodic dysthymia and anxiety who are unlikely to benefit greatly from antidepressants. Diagnostic criteria for a revival of the concept of neurotic depression are proposed.

  18. [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].

    Science.gov (United States)

    Dematteis, Maurice; Pennel, Lucie; Mallaret, Michel

    2012-05-01

    Gamma-hydroxybutyric acid (GHB) is an old anaesthetic drug which was misused in the 80-90's as an anabolic agent (bodybuilding), recreational drug (drunkenness, euphoric, disinhibiting and aphrodisiac effects) and as a date rape drug (disinhibiting, hypnotic and amnesic effects). Its use in the general population is low, and mainly concerns gay population in nightclubs and young people in parties. The intoxications, above all with alcohol combination, can be severe, with coma and breathing depression, or even fatal. Chronic use leads to psychic and physical dependence; withdrawal syndrome can be severe, with agitation and delirium. In 1999, GHB classification as a narcotic resulted in the increased use of GHB prodrugs gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), which were easily commercially available as solvent and cleaning products. Like GHB, they have a narrow window of use, and share similar toxicity. Their increased cases of recreational use and of severe drug intoxication, abuse and dependence, led the French Ministry of Health in 2011 to prohibit their sale and transfer to the public.

  19. Analytical performance of RNA isolated from BD SurePath™ cervical cytology specimens by the PreTect™ HPV-Proofer assay.

    Science.gov (United States)

    Dixon, Eric P; Grønn, Petter; King, Lorraine M; Passineau, Heather; Doobay, Hema; Skomedal, Hanne; Hariri, Jalil; Hay, Shauna N; Brown, Charlotte A; Fischer, Timothy J; Malinowski, Douglas P

    2012-11-01

    Several commercial HPV ancillary tests are available for detection of E6/E7 RNA. It is not clear how storage of a cervical Pap affects the analytical and clinical performance of the PreTect™ HPV-Proofer assay. To investigate the qualitative performance of RNA extracted from BD SurePath™ liquid-based cytology (LBC) specimens for the detection of human papillomavirus (HPV) E6/E7 mRNA using the PreTect™ HPV-Proofer assay, studies including stability, reproducibility, residual specimen analysis, and storage medium comparison assays were performed. Cervical cytology specimens were collected and stored in BD SurePath™ LBC preservative fluid and/or PreTect™ Transport Media. RNA was isolated using the RecoverAll™ Total Nucleic Acid Isolation kit and RNA integrity was evaluated in the PreTect™ HPV-Proofer assay. The performance of RNA isolated from cervical cells collected and stored in BD SurePath™ LBC preservative fluid or PreTect™ Transport Media was also evaluated through a storage medium comparison study. The RNA was found to be stable for a minimum of 21 days when stored at ambient temperature and displayed high reproducibility with the mean percentage reproducibility ranging from 90.5% to 100% for the HPV types detected by the PreTect™ HPV-Proofer assay. The prevalence rate of HPV types in this study cohort was consistent with published reports. A 93.7% first pass acceptance rate was demonstrated across all cytology grades. The positive human U1 snRNP specific A protein (U1A) and HPV rate for BD SurePath™ LBC and PreTect™ Transport Media specimens was statistically equivalent for both normal and abnormal specimens. This data support the use of RNA isolated from BD SurePath™ LBC for ancillary HPV testing and demonstrates the feasibility of using BD SurePath™ preservative fluid as a specimen type with the PreTect™ HPV-Proofer assay.

  20. Comparison of Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometer to BD Phoenix automated microbiology system for identification of gram-negative bacilli.

    Science.gov (United States)

    Saffert, Ryan T; Cunningham, Scott A; Ihde, Sherry M; Jobe, Kristine E Monson; Mandrekar, Jayawant; Patel, Robin

    2011-03-01

    We compared the BD Phoenix automated microbiology system to the Bruker Biotyper (version 2.0) matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) system for identification of gram-negative bacilli, using biochemical testing and/or genetic sequencing to resolve discordant results. The BD Phoenix correctly identified 363 (83%) and 330 (75%) isolates to the genus and species level, respectively. The Bruker Biotyper correctly identified 408 (93%) and 360 (82%) isolates to the genus and species level, respectively. The 440 isolates were grouped into common (308) and infrequent (132) isolates in the clinical laboratory. For the 308 common isolates, the BD Phoenix and Bruker Biotyper correctly identified 294 (95%) and 296 (96%) of the isolates to the genus level, respectively. For species identification, the BD Phoenix and Bruker Biotyper correctly identified 93% of the common isolates (285 and 286, respectively). In contrast, for the 132 infrequent isolates, the Bruker Biotyper correctly identified 112 (85%) and 74 (56%) isolates to the genus and species level, respectively, compared to the BD Phoenix, which identified only 69 (52%) and 45 (34%) isolates to the genus and species level, respectively. Statistically, the Bruker Biotyper overall outperformed the BD Phoenix for identification of gram-negative bacilli to the genus (P gram-negative bacilli (P > 0.05). However, the Bruker Biotyper outperformed the BD Phoenix for identification of infrequently isolated gram-negative bacilli (P < 0.0001).

  1. Increase in osmotolerance of Rhizobium fredii soybean isolate BD32 by the proB proA operon of Escherichia coli.

    Science.gov (United States)

    Neumivakin, L V; Solovjev, V P; Sokhansanj, A; Tilba, V A; Moseiko, N A; Shachbasian, R V; Piruzian, E S

    1995-12-26

    The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm proA), were transferred into a low level osmotolerance Rhizobium fredii strain BD32. Both types of transconjugants were characterised by increased osmotolerance in a minimal medium supplied with 0.4-0.8 M NaCl but in the case of pNSA the effect was more significant. The strain BD32/pNSA had an increased level of intracellular proline concentration. Practical application of the increase in Rhizobium resistance to the stress factors is discussed.

  2. Molecular Docking Study Characterization of Rare Flavonoids at the Nac-Binding Site of the First Bromodomain of BRD4 (BRD4 BD1

    Directory of Open Access Journals (Sweden)

    Karthik Dhananjayan

    2015-01-01

    Full Text Available ε-N-Acetylation of lysine residues (Kac is one of the most frequently occurring posttranslational modifications (PTMs which control gene transcription and a vast array of diverse cellular functions. Bromodomains are epigenetic regulators involved in posttranslational modification. In silico docking studies were carried out to evaluate the binding potential of selected rare flavonoids on to Nac binding site of BD1 domain of BRD4 BET family proteins. Rare flavonoids like 3-O-acetylpinobanksin, naringenin triacetate, and kaempferol tetraacetate were found to occupy the WPF shelf and at the same time they exhibited a better binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1 when compared with the known inhibitors.

  3. Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines.

    Science.gov (United States)

    Quang, Lawrence S; Colombo, Giancarlo; Lobina, Carla; Maccioni, Paola; Orru, Alessandro; Gessa, Gian Luigi; Maher, Timothy J; Carai, Mauro A M

    2006-08-01

    A severe and life-threatening gamma-hydroxybutyric acid (GHB) withdrawal syndrome, clinically similar to the alcohol withdrawal syndrome, is increasingly being reported in GHB addicts. We investigated for the occurrence of withdrawal in Wistar and Sprague-Dawley rats, and in the selectively bred lines of GHB-sensitive (GHB-S) and Sardinian alcohol-preferring (sP) rats, following chronic administration of GHB, gamma-butyrolactone (GBL), and/or 1,4-butanediol (1,4-BD). Using validated rodent alcohol withdrawal scoring scales, little to no spontaneous or pharmacologically precipitated withdrawal effects were observed in Wistar, Sprague-Dawley, or GHB-S rats. Conversely, sP rats displayed both spontaneous and precipitated audiogenic seizures following abrupt cessation of chronic GHB or 1,4-BD administration and following pharmacological challenge with the GABA(B) receptor-selective antagonist, SCH 50911, respectively.

  4. Measurement of the angular and lifetime parameters of the decays Bd0-->J/psiK*0 and Bs0-->J/psiphi.

    Science.gov (United States)

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Andrieu, B; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Assis Jesus, A C S; Atramentov, O; Avila, C; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Bu, X B; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Carrasco-Lizarraga, M A; Carrera, E; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Crépé-Renaudin, S; Cuplov, V; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; DeVaughan, K; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Garcia, C; Garcia-Bellido, A; Garcia-Guerra, G A; Gavrilov, V; Gay, P; Geist, W; Geng, W; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kau, D; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y M; Khatidze, D; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Komissarov, E V; Konrath, J-P; Kozelov, A V; Kraus, J; Kuhl, T; Kumar, A; Kupco, A; Kurca, T; Kuzmin, V A; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G; Lebrun, P; Lee, W M; Leflat, A; Lellouch, J; Li, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Love, P; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Maravin, Y; Martin, B; McCarthy, R; Meijer, M M; Melnitchouk, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Mitrevski, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osman, N; Osta, J; Otec, R; Otero y Garzón, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Polozov, P; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Tanasijczuk, A; Taylor, W; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Torchiani, I; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vilanova, D; Villeneuve-Seguier, F; Vint, P; Vokac, P; Voutilainen, M; Wagner, R; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Welty-Rieger, L; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Williams, M; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Yin, H; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zeitnitz, C; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2009-01-23

    We present measurements of the linear polarization amplitudes and the strong relative phases that describe the flavor-untagged decays Bd0-->J/psiK*0 and Bs0-->J/psiphi in the transversity basis. We also measure the mean lifetime taus of the Bs0 mass eigenstates and the lifetime ratio taus/taud. The analyses are based on approximately 2.8 fb(-1) of data recorded with the D0 detector. From our measurements of the angular parameters we conclude that there is no evidence for a deviation from flavor SU(3) symmetry for these decays and that the factorization assumption is not valid for the Bd0-->J/psiK*0 decay.

  5. Natural genetic transformation in Acinetobacter sp. BD413 Biofilms: introducing natural genetic transformation as a tool for bioenhancement of biofilm reactors

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickx, L.

    2002-07-01

    This study focussed on the localization and quantification of natural genetic transformation using neutral and disadvantageous genes in monoculture biofilms to investigate gene transfer and expression of the transferred genes in the absence of a selective advantage. Data obtained by this investigation were regarded as initial steps for evaluating the applicability of adding catabolic traits into the indigenous bacterial community of biofilm reactors by in situ natural genetic transformation. Because Acinetobacter spp. strains are readily found in waste water treatment plants and because Acinetobacter sp. BD413 possesses a high effective level of competence, natural genetic transformation was investigated in monoculture Acinetobacter sp. BD413 biofilms. The genes used for transformation encoded for the green fluorescent protein (GFP) and its variants. Monitoring of transformation events were performed with the use of automated confocal laser scanning microscopy (CLSM) and semi automated digital image processing and analysis. (orig.)

  6. Measurement of the B_s^0→K^+K^- lifetime relative to the B_d^0→K^+π^- lifetime

    CERN Document Server

    Cliff, H; Kerzel, U

    2009-01-01

    The study of B decays to charmless charged hadrons offers an opportunity to improve our understanding CP violation and to search for New Physics beyond the Standard Model. We present an analysis to make a measurement of the B_s^0→K^+K^- lifetime relative to B_d^0 lifetime which removes systematic bias introduced to the lifetime by distance of flight based selections.

  7. CP violation study in $Bd \\to J/\\Psi(\\mu\\mu) Ks(\\pi\\pi)$ decay, vertex reconstruction and muon identification for the LHCb experiment

    CERN Document Server

    Nunes-Pereira, C

    The LHCb experiment is to precise measurements of CP violation in B-meson system and to the study of B decays. This work describes the performance study for the LHCb measurement of sin (2beta) from Bd to J/Psi(mumu) Ks(pipi) CP asymmetry, the performance study for two vertex constrained fitting tools and the study of the contamination reduction in muon identification for LHCb.

  8. Development of a Real-Time PCR Protocol Requiring Minimal Handling for Detection of Vancomycin-Resistant Enterococci with the Fully Automated BD Max System.

    Science.gov (United States)

    Dalpke, Alexander H; Hofko, Marjeta; Zimmermann, Stefan

    2016-09-01

    Vancomycin-resistant enterococci (VRE) are an important cause of health care-associated infections, resulting in significant mortality and a significant economic burden in hospitals. Active surveillance for at-risk populations contributes to the prevention of infections with VRE. The availability of a combination of automation and molecular detection procedures for rapid screening would be beneficial. Here, we report on the development of a laboratory-developed PCR for detection of VRE which runs on the fully automated Becton Dickinson (BD) Max platform, which combines DNA extraction, PCR setup, and real-time PCR amplification. We evaluated two protocols: one using a liquid master mix and the other employing commercially ordered dry-down reagents. The BD Max VRE PCR was evaluated in two rounds with 86 and 61 rectal elution swab (eSwab) samples, and the results were compared to the culture results. The sensitivities of the different PCR formats were 84 to 100% for vanA and 83.7 to 100% for vanB; specificities were 96.8 to 100% for vanA and 81.8 to 97% for vanB The use of dry-down reagents and the ExK DNA-2 kit for extraction showed that the samples were less inhibited (3.3%) than they were by the use of the liquid master mix (14.8%). Adoption of a cutoff threshold cycle of 35 for discrimination of vanB-positive samples allowed an increase of specificity to 87.9%. The performance of the BD Max VRE assay equaled that of the BD GeneOhm VanR assay, which was run in parallel. The use of dry-down reagents simplifies the assay and omits any need to handle liquid PCR reagents.

  9. BD Andromedae: A new short-period RS CVn eclipsing binary star with a distant tertiary body in a highly eccentric orbit

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chun-Hwey; Song, Mi-Hwa; Yoon, Jo-Na; Jeong, Min-Ji [Department of Astronomy and Space Science, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Han, Wonyong, E-mail: kimch@chungbuk.ac.kr [Korea Astronomy and Space Institute, Daejeon 305-348 (Korea, Republic of)

    2014-06-20

    A photometric study of BD And was made through the analysis of two sets of new BVR light curves. The light curves with migrating photometric waves outside eclipse show that BD And is a short-period RS CVn-type binary star. The analysis of all available timings reveals that the orbital period has varied in a strictly cyclical way with a period of 9.2 yr. The periodic variation most likely arises from the light-time effect due to a tertiary moving in a highly elliptical orbit (e {sub 3} = 0.76). The Applegate mechanism could not operate properly in the eclipsing pair. The light curves were modeled with two large spots on the hotter star and a large third light amounting to about 14% of the total systemic light. BD And is a triple system: a detached binary system consisting of two nearly equal solar-type stars with an active primary star and a G6-G7 tertiary dwarf. The absolute dimensions of the eclipsing pair and tertiary components were determined. The three components with a mean age of about 5.8 Gyr are located at midpositions in main-sequence bands. The radius of the secondary is about 17% larger than that deduced from stellar models. The orbital and radiometric characteristics of the tertiary are intensively investigated. One important feature is that the mutual inclination between two orbits is larger than 60°, implying that Kozai cycles had occurred very efficiently in the past. The possible past and future evolutions of the BD And system, driven by KCTF and MBTF, are also discussed.

  10. Entering a foreign labour market via the “academic gate”. The experiences of Poles who came as international students to Germany Der Arbeitsmarkteinstieg im Anschluss an der Nachschulausbildung im Ausland. Erfahrungen polnischer Studierender in Deutschland

    Directory of Open Access Journals (Sweden)

    Nina Wolfeil

    2012-12-01

    Full Text Available Against the background of debates on needs for highly-skilled labour in Germany, the article is interested in international students as a special group of Highly-Skilled Migration. It analyses the impact of studying abroad on future mobility and career patterns. The article presents results from an online survey and 27 qualitative interviews with Poles who came as international students and who later on entered the German labour market. Results from the online survey indicate that approximately 70 % return to Poland but lower return rates are observed among degree-seeking students than among exchange students. The professional value of the study abroad experience is very high. A qualitative typology comprising four types (“Brain Circulators”, “Polonia Members”, “International Career”, “Transformation Refugees” shows how former international students combine Polish and German cultural capital in their professional life and identifies success and failed stories. As a result, special programmes should be created to smooth the transition from university to the labour market in the study abroad destination.Vor dem Hintergrund der Debatte um einen Fachkräftemangel in Deutschland beschäftigt sich der Beitrag mit internationalen Studierenden als Subgruppe der Hochqualifiziertenmigration. Er analysiert den Einfluss des Auslandsstudiums auf spätere Mobilitäts- und Karrieremuster und präsentiert empirische Ergebnisse aus einer Online-Befragung und 27 qualitativen Interviews mit polnischen Absolventen, die als internationale Studierende nach Deutschland kamen und im Anschluss an ihr Studium eine Beschäftigung in Deutschland aufnahmen. Nach den Ergebnissen der Online-Befragung kehren ca. 70 % nach Polen zurück, wobei allerdings Studierende, die einen Abschluss erwarben, eine weitaus geringere Rückkehrquote aufweisen als Austauschstudierende. Der berufliche Ertrag des Auslandsstudiums ist hoch. Eine vier Typen umfassende qualitative

  11. A guide for implementation of the European Pollutant Emission Register (EPER) in Germany; Leitfaden zur Umsetzung des Europaeischen Schadstoffemissionsregisters (EPER) in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Kuehne, C.; Striegel, G.

    2001-10-01

    The report presents specifications for implementing the European Pollutant Emission Register (EPER) in Germany. [German] Gemaess Artikel 15 (3) der Richtlinie 96/61/EG ueber die integrierte Vermeidung und Verminderung der Umweltverschmutzung ('IVU-Richtlinie') veroeffentlicht die Kommission alle drei Jahre ein Verzeichnis der wichtigsten Emissionen und ihrer Quellen anhand der von den Mitgliedstaaten uebermittelten Informationen. Fuer die Mitgliedstaaten ergibt sich hieraus die Verpflichtung, die erforderlichen Daten zu erheben, auszuwerten und der Europaeischen Kommission zu berichten. In der Entscheidung der Kommission vom 17. Juli 2000 ueber den Aufbau eines Europaeischen Schadstoffemissionsregisters (EPER- 'European Pollutant Emission Register') 2000/479/EG ('EPER-Entscheidung') werden die Anforderungen an Inhalt und Form dieses Verzeichnisses konkretisiert: - Die Mitgliedstaaten berichten der Kommission ueber die Emissionen in die Luft und in das Wasser aus einzelnen Betriebseinrichtungen. Zu berichten sind die Emissionen bestimmter Schadstoffe, die ueber vorgegebenen Schwellenwerten liegen. Das Berichtsformat fuer die Mitgliedstaaten ist im Anhang A2 der EPER-Entscheidung festgelegt. - Der erste Bericht ist im Juni 2003 vorzulegen und soll Angaben ueber Emissionen im Jahr 2001 (bzw. wahlweise 2000 oder 2002) enthalten. Jeder Mitgliedstaat muss zudem einen zusammenfassenden nationalen Uebersichtsbericht erstellen. - Die Europaeische Kommission wird die Emissionsdaten ueber das Internet der Oeffentlichkeit zugaenglich machen. Fuer die Erhebung der fuer das EPER erforderlichen Daten in Deutschland wird ein schrittweises Vorgehen empfohlen: - Am Anfang steht die Identifizierung von Betriebseinrichtungen mit Taetigkeiten nach Anhang I der IVU-Richtlinie. - Angabe des NACE-Kodes der Betriebseinrichtung und Zuordnung der Anhang I-Taetigkeiten (Quellenkategorie) und des NOSE-P-Kodes gemaess Anhang A3 der EPER-Entscheidung. - Festlegung

  12. Effects of replacement of low-spin haem b by haem O on Escherichia coli cytochromes bo and bd quinol oxidases.

    Science.gov (United States)

    Mogi, Tatsushi

    2009-05-01

    Cytochromes bo and bd are terminal ubiquinol oxidases in the aerobic respiratory chain of Escherichia coli and generate proton motive force across the membrane. To probe roles of haem species in the oxidation of quinols, intramolecular electron transfer and the dioxygen reduction, we replaced b-haems with haem O by using the haem O synthase-overproducing system, which can accumulate haem O in cytoplasmic membranes. Characterizations of spectroscopic properties of cytochromes bo and bd isolated from BL21 (DE3)/pLysS and BL21 (DE3)/pLysS/pTTQ18-cyoE after 4 h of the aerobic induction of haem O synthase (CyoE) showed the specific incorporation of haem O into the low-spin haem-binding site in both oxidases. We found that the resultant haem oo- and obd-type oxidase severely reduced the ubiquinol-1 oxidase activity due to the perturbations of the quinol oxidation site. Our observations suggest that haem B is required at the low-spin haem site for the oxidation of quinols by cytochromes bo and bd.

  13. Guillem Peire de Cazals, “Be·m plagr’ueymais qu’ab vos dona·m valgues” (BdT 227.6

    Directory of Open Access Journals (Sweden)

    Alessio Collura

    2011-12-01

    Full Text Available This paper proposes a new edition with commentary of the poem “Be·m plagr’ueymais qu’ab vos, dona, ·m valgues” by Guillem Peire de Cazals and represents a first critical and hermeneutical reassessment of the poetry of the troubadour from Cahors, that has long been neglected. The text presents the classical structure of a love-story (springtime exordium, singing brought on by love, the theme of improvement, courting with no hope of a reward, a request for mercé and invites the fin aman to be patient. The song is examined from the viewpoint of its metrical and stylistic relations to other troubadour poems (Bernart de Ventadorn, “Can par la flors josta·l vert folh” [BdT 70.41] and “La dousa votz ai auzida” [BdT 70.23] and Lanfranc Cigala, “Ioios d’amor farai de ioi senblan” [BdT 282.12], and represents an early example of the mannerisms and experimental tendencies that characterize Guillem Peire’s poems. The article also attempts to date the composition to the twenties or thirties of the 13th century.

  14. A multiwavelength approach to BD+53$^\\circ$2790: the O9.5V counterpart to the X-ray binary system 4U~2206+54

    CERN Document Server

    Blay, Pere

    2011-01-01

    The X-ray binary system 4U 2206+54 hides many mysteries. Among them, the surprising behavior of both of its components: the O9.5 dwarf star BD+53$^\\circ$2790 and a slowly rotating neutron star. BD+53$^\\circ$2790 misled the astronomers showing itself very likely as a Be star. However, a deeper spectral analysis and more intense monitoring, revealed that the real picture was a bit more complicated: a) Although it shows evidence of a circumstellar envelope, its observable properties differ from those typical envelopes in Be stars. b) Comparison with spectral standards and models indicates a possible over-abundance in He. This would open the possibility to link the behavior of BD+53$^\\circ$2790 to the He-rich class of stars. c) UV spectra shows an abnormally slow and dense wind for an O9.5V star. d) Spectral classification in the IR wavelength region suggest a more likely supergiant nature of the source, in contradiction with the optical classification. e) The presence of an intense magnetic field is under invest...

  15. Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method.

    Science.gov (United States)

    Rosi, Luca; Frediani, Piero; Bartolucci, Gianluca

    2013-02-23

    Gamma-hydroxybutyric acid (GHB) and its "pro-drugs", gamma-butyrolactone (GBL) and 1,4 butanediol (1,4-BD), are drugs of abuse with depressant effects on the central nervous system. Many analytical methods have been proposed for the quantitative determination of these compounds mainly in biological matrices but only few have been addressed to dietary supplements and foods. Facile synthesis of the GBL and 1,4-BD isotopologues are available by "one pot" Ru-catalyzed homogeneous deuteration of dicarboxylic acids. In this work we propose a new method for determination of GHB, GBL and 1,4-BD in commercially available dietary supplements, based on isotope dilution mass spectrometry (ID-MS). The procedure involves a simple extraction of sample with acidic acetonitrile and direct analysis by GC-ID-MS method without any purification or derivatization. Indeed, the proposed method takes advantage of the complete conversion of GHB (free acid or its salts) to GBL, allowing the quantification of GHB and its pro-drugs. Five levels for each calibration curve have been prepared by diluting working solutions of the analytes to obtain concentrations ranging from 1 to 20mg/mL. The validation procedures have shown an accuracy between 88% and 99% and a precision between 7.3% and 2.9% of each analyte in the sample matrix. Positive ions chemical ionization (PICI) have been employed to preserve the information on molecular ions and to improve specificity and sensitivity of quantitative determination.

  16. In addition to its antiviral and immunomodulatory properties, the zebrafish β-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant.

    Science.gov (United States)

    García-Valtanen, P; Martinez-Lopez, A; Ortega-Villaizan, M; Perez, L; Coll, J M; Estepa, A

    2014-01-01

    It is well known that β-defensins are key components of the host innate immune response against pathogens and potentially provide a link between innate and adaptive immunity. In zebrafish (Danio rerio), a vertebrate model species in numerous biomedical fields, three β-defensin isoforms were recently identified. To our knowledge, however, studies describing antimicrobial or immunomodulatory properties of any of the zebrafish β-defensins isoforms are absent today. Since it is indubitable that deepening the study of zebrafish β-defensins would be of interest in this work we investigated whether or not the zebrafish β-defensin 2 (zfBD2) has the antiviral properties described for their vertebrate counterparts. Our in vitro and in vivo studies showed that zfBD2 has antiviral activity, immunomodulatory properties and, most importantly, is a potent viral DNA vaccine molecular adjuvant. In addition, a potential relationship between zfBD2 activity and the NF-κB signaling pathway is suggested. Altogether these results show that the zebrafish could be a suitable in vivo animal model to study the roles played by β-defensin 2 in viral diseases, vaccinology and even in clinical dermatology. To note that psoriasis can be induced in zebrafish and the over-expression of β-defensin 2 is implicated in the inflammatory response associated with this human skin disorder.

  17. Quantitative spectroscopy of extreme helium stars Model atmospheres and a non-LTE abundance analysis of BD+10°2179

    Science.gov (United States)

    Kupfer, T.; Przybilla, N.; Heber, U.; Jeffery, C. S.; Behara, N. T.; Butler, K.

    2017-10-01

    Extreme helium stars (EHe stars) are hydrogen-deficient supergiants of spectral type A and B. They are believed to result from mergers in double degenerate systems. In this paper, we present a detailed quantitative non-LTE spectral analysis for BD+10°2179, a prototype of this rare class of stars, using UV-Visual Echelle Spectrograph and Fiber-fed Extended Range Optical Spectrograph spectra covering the range from ∼3100 to 10 000 Å. Atmosphere model computations were improved in two ways. First, since the UV metal line blanketing has a strong impact on the temperature-density stratification, we used the atlas12 code. Additionally, We tested atlas12 against the benchmark code sterne3, and found only small differences in the temperature and density stratifications, and good agreement with the spectral energy distributions. Secondly, 12 chemical species were treated in non-LTE. Pronounced non-LTE effects occur in individual spectral lines but, for the majority, the effects are moderate to small. The spectroscopic parameters give Teff =17 300±300 K and log g = 2.80±0.10, and an evolutionary mass of 0.55±0.05 M⊙. The star is thus slightly hotter, more compact and less massive than found in previous studies. The kinematic properties imply a thick-disc membership, which is consistent with the metallicity [Fe/H] ≈ -1 and α-enhancement. The refined light-element abundances are consistent with the white dwarf merger scenario. We further discuss the observed helium spectrum in an appendix, detecting dipole-allowed transitions from about 150 multiplets plus the most comprehensive set of known/predicted isolated forbidden components to date. Moreover, a so far unreported series of pronounced forbidden He I components is detected in the optical-UV.

  18. Comparison of nucleic acid amplification assays with BD affirm VPIII for diagnosis of vaginitis in symptomatic women.

    Science.gov (United States)

    Cartwright, Charles P; Lembke, Bryndon D; Ramachandran, Kalpana; Body, Barbara A; Nye, Melinda B; Rivers, Charles A; Schwebke, Jane R

    2013-11-01

    A commercially available, nonamplified, nucleic acid probe-based test system (BD Affirm VPIII) was compared with nucleic acid amplification (NAA)-based assays for determining the etiology of vaginitis in a cohort of 323 symptomatic women. First, a semiquantitative, multiplexed PCR assay (BV-PCR) and the Affirm VPIII Gardnerellavaginalis test were compared with a unified bacterial-vaginosis (BV) reference standard incorporating both Nugent Gram stain scores and Amsel clinical criteria. In the evaluable population of 305 patients, BV-PCR was 96.9% (191/197) sensitive and 92.6% specific (100/108) for BV, while Affirm VPIII was 90.1% sensitive (179/197) and 67.6% specific (73/108). Second, a multiplexed PCR assay detecting Candida albicans and Candida glabrata (CAN-PCR) was compared with the Affirm VPIII Candida test using a reference standard for vulvovaginal candidiasis (VVC) of yeast culture plus exclusion of alternate vaginitis etiologies. In the population evaluated (n = 102), CAN-PCR was 97.7% sensitive (42/43) and 93.2% specific (55/59) and Affirm VP III was 58.1% sensitive (25/43) and 100% specific (59/59) for VVC. Finally, the results of a commercial NAA test (GenProbe Aptima Trichomonas vaginalis assay; ATV) for T. vaginalis were compared with the Affirm VPIII Trichomonas vaginalis test. In the absence of an independent reference standard for trichomonal vaginitis (TV), a positive result in either assay was deemed to represent true infection. In the evaluable cohort of 388 patients, the sensitivity of ATV was 98.1% (53/54) versus 46.3% (25/54) for Affirm VPIII. The diagnostic accuracy of the combined NAA-based test construct was approximately 20 to 25% higher than that of the Affirm VPIII when modeled in populations with various prevalences of infectious vaginitis.

  19. Svingningsteori, Bd. 1

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.

    Nærværende lærebog er skrevet med henblik på undervisningen i lineær svingingsteori på konstruktionsliniens 8. semester på Aalborg Universitetscenter. Det pågældende kursus danner grundlaget for efterfølgende undervisning i ikke-lineær svingningsteori, hvilket har påvirket fremstillingens form. D...

  20. BD2/GPS四频高精度接收机在远望号船姿测量中的应用%Attitude Measurement with High-Precision Dual-System Quad-Frequency BD2/GPS Receiver in Yuanwang Surveying Ship

    Institute of Scientific and Technical Information of China (English)

    周健; 毛刚; 赵李健; 王珏

    2012-01-01

    With the gradual improvement of the construction of Beidou satellite navigation system and the rapid spread of the Beidou application, BD2/GPS positioning terminal equipment has been widely used in various fields. The attitude measurement with high-precision dual-system quad-frequency BD2/GPS receiver in the o-cean-going surveying ship was described, and the attitude determination accuracy with the traditional single GPS receiver was compared, the analysis of the Beidou satellite system's role in attitude measurement and the advantages was made.%随着我国北斗卫星导航系统建设的逐步完善以及北斗应用的迅速推广,BD2/GPS定位终端设备已经开始广泛地应用于各个领域中.介绍了BD2/GPS双系统四频高精度接收机在远望号测量船船姿测量中的应用;并与传统的单一GPS接收机的测姿精度进行比对,分析北斗卫星导航系统在姿态测量中的作用与优势.

  1. The orbital elements and physical properties of the eclipsing binary BD+36°3317, a probable member of δ Lyrae cluster

    Science.gov (United States)

    Kıran, E.; Harmanec, P.; Değirmenci, Ö. L.; Wolf, M.; Nemravová, J.; Šlechta, M.; Koubský, P.

    2016-03-01

    Context. The fact that eclipsing binaries belong to a stellar group is useful, because the former can be used to estimate distance and additional properties of the latter, and vice versa. Aims: Our goal is to analyse new spectroscopic observations of BD+ 36°3317 along with the photometric observations from the literature and, for the first time, to derive all basic physical properties of this binary. We aim to find out whether the binary is indeed a member of the δ Lyr open cluster. Methods: The spectra were reduced using the IRAF program and the radial velocities were measured with the program SPEFO. The line spectra of both components were disentangled with the program KOREL and compared to a grid of synthetic spectra. The final combined radial-velocity and photometric solution was obtained with the program PHOEBE. Results: We obtained the following physical elements of BD+36°3317: M1 = 2.24 ± 0.07 M⊙, M2 = 1.52 ± 0.03 M⊙, R1 = 1.76 ± 0.01 R⊙, R2 = 1.46 ± 0.01 R⊙, log L1 = 1.52 ± 0.08 L⊙, log L2 = 0.81 ± 0.07 L⊙. We derived the effective temperatures Teff,1 = 10 450 ± 420 K, Teff,2 = 7623 ± 328 K. Both components are located close to zero age main sequence in the Hertzsprung-Russell (HR) diagram and their masses and radii are consistent with the predictions of stellar evolutionary models. Our results imply the average distance to the system d̅ = 330 ± 29 pc. We re-investigated the membership of BD+ 36°3317 in the δ Lyr cluster and confirmed it. The distance to BD+ 36°3317, given above, therefore represents an accurate estimate of the true distance for δ Lyr cluster. Conclusions: The reality of the δ Lyr cluster and the cluster membership of BD+ 36°3317 have been reinforced.

  2. 基于三步逼近的BD2高精度快速捕获算法研究%High-accuracy fast acquisition algorithm research for BD2 signals based on three-step approximation

    Institute of Scientific and Technical Information of China (English)

    林智吉; 易清明; 石敏

    2015-01-01

    For low accuracy and heavy computation in acquisition module of BeiDou-2 navigation satellite system software receiver, a high accuracy and fast acquisition algorithm based on three-step approximation is proposed. Based on variable-step three-step approximation for narrowing search range of Doppler frequency shift gradually, it quickly acquires accurate initial code phase and Doppler frequency offset. Frequency circular shift is used to reduce computation burden of acquisition module by replacing FFT operations with one multiplication in the first step. Experimental results show that accurate Pseudo-Random Noise(PRN)code offset and carrier frequency error within 100 Hz can be acquired. Compared to the computation amount of traditional parallel code phase algorithm, it is reduced by average 70.56%in the optimal circumstances.%针对BeiDou-2(BD2)卫星导航软件接收机捕获模块中捕获精度低和运算量大的问题,提出了一种基于三步逼近的高精度快速捕获算法。算法采用变步长的三步逼近方法逐步缩小多普勒频移搜索范围,快速得到了精确的初始码相位和多普勒频偏;利用频率圆周移位方法,在第一步搜索以一次乘法代替FFT操作,较大地减少了捕获模块的运算负担。实验结果证明,该算法捕获的伪码偏移精确、载频偏移误差在100 Hz以内,且最优情况下的运算量比传统的并行码相位捕获算法平均减少了70.56%,运算效率高。

  3. Genital and extra-genital screening for gonorrhoea using the BD Probetec ET system with an in-house PCR method targeting the porA pseudogene as confirmatory test

    DEFF Research Database (Denmark)

    Skovgaard, Sissel; Larsen, Helle Kiellberg; Sand, Carsten;

    2012-01-01

    for Chlamydia trachomatis testing were also examined for GC on the BD Viper™ platform using the BD Probetec ET system. In order to avoid false-positive results all GC BD reactive samples were re-tested using a PCR method with the porA pseudogene as target. Using this method we screened 170% more samples for GC...... than in the previous year, in the same population, and diagnosed more than twice as many GC-positive episodes. The BD system can be used successfully to screen extra-genital as well as genital specimen types for GC in a low-prevalence area if it is combined with a validated confirmatory PCR test....

  4. Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993 [Rezension

    OpenAIRE

    Liedtke, Max

    1994-01-01

    Rezension von: Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993, 242 S.

  5. [Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung; B. 2 : Die Sicht auf Krieg, Diktat

    Index Scriptorium Estoniae

    Hecker-Stampehl, Jan

    2011-01-01

    Arvustus : Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung. Berlin : LIT Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 14); Bd. 2 : Die Sicht auf Krieg, Diktatur, Völkermord, Besatsung und Vertreibung in Russland, Polen und den baltischen Staaten. Berlin: Lit Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 15)

  6. [Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung; B. 2 : Die Sicht auf Krieg, Diktat

    Index Scriptorium Estoniae

    Hecker-Stampehl, Jan

    2011-01-01

    Arvustus : Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung. Berlin : LIT Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 14); Bd. 2 : Die Sicht auf Krieg, Diktatur, Völkermord, Besatsung und Vertreibung in Russland, Polen und den baltischen Staaten. Berlin: Lit Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 15)

  7. Wirkungen aktiver Arbeitsmarktpolitik : Evaluierungsergebnisse für Deutschland, Schweden, Dänemark und die Niederlande ; Gutachten im Auftrag des Bundeskanzleramtes für die Benchmarking-Gruppe des Bündnisses für Arbeit, Ausbildung und Wettbewerbsfähigkeit

    OpenAIRE

    Rabe, Birgitta

    2000-01-01

    "Hohe Teilnehmerzahlen sowie ein beträchtlicher Mitteleinsatz für arbeitsmarktpolitische Maßnahmen haben in den letzten Jahren zu einem gesteigerten Interesse an den Wirkungen aktiver Arbeitsmarktpolitik geführt. In dieser Literaturstudie wird daher danach gefragt, was sich nach dem aktuellen Stand der Evaluierungsforschung über die bisherige Wirksamkeit aktiver Arbeitsmarktpolitik in Deutschland sagen lässt. Welche Instrumente funktionieren für welche Personengruppen und welche Maßnahmengest...

  8. Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.

    Science.gov (United States)

    Towiwat, Pasarapa; Phattanarudee, Siripan; Maher, Timothy J

    2013-01-01

    Gamma-hydroxybutyrate (GHB), and its precursors 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) are known drugs of abuse. The ability of acute and chronic administration of equimolar doses of GHB (200mg/kg), 1,4-BD (174mg/kg) and GBL (166mg/kg) to produce catalepsy in male Swiss Webster mice was examined. GHB, 1,4-BD, GBL produced catalepsy when injected acutely. Drug treatment was then continued for 14days. Tolerance development was determined on days 6, 14, and challenged with a higher dose on day 15 in those chronically pretreated mice, and compared with naïve mice. Chronic GHB produced tolerance to catalepsy, as evidenced from area under the curve (AUC) of catalepsy versus time (min-sec) on days 6 (678±254), 14 (272±247), which were less than those on day 1 (1923±269). However, less tolerance was seen from GBL or 1,4-BD, as AUCs on days 6 and 14 were not significantly lower than that of day 1. In conclusion, although equimolar doses were used, expecting similar levels of GHB in the body, 1,4-BD and GBL shared only some of the in vivo effects of GHB. The rate of metabolic conversion of 1,4-BD and GBL into GHB might be responsible for the differences in the tolerance development to these drugs.

  9. Emission control measures for precursors of tropospheric ozone. Pt. 1 and 2; Emissionsminderungsmoeglichkeiten bei Vorlaeufersubstanzen von bodennahem Ozon. Bd. 1: Systemanalyse der Ozonminderungsmassnahmen in den USA. Bd. 2: Luftreinhaltemassnahmen in den USA zur Minderung von VOC-Emissionen aus Kleinanlagen und Produkten und Vergleich mit europaeischen Regelungen

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, T.; Schiefer, C.; Bergmann, S.; Hrabovski, Z. [Institut fuer Umwelttechnologie und Umweltanalytik e.V. (IUTA), Duisburg (Germany)

    1998-08-01

    emissions are compared and discussed. Advantages and disadvantages of the described strategies are highlighted. Based on the actual VOC emission inventory of Germany suggestions for future reduction measures are supposed. (orig.) [Deutsch] In den USA liegen Erfahrungen aus der Ozonbekaempfung ueber einen Zeitraum von 20 bis 30 Jahren vor. Aufgrund besonders hoher Ozonbelastungen in vielen Regionen werden grosse Anstrengungen zur VOC-Minderung unternommen. Wesentliches Ziel des Vorhabens war es, die Schwerpunkt im Hinblick auf die Minderung von VOC-Emissionen herauzufinden und zu pruefen, ob und inwieweit eine Uebertragung von Strategien und Massnahmen auf die Verhaeltnisse in Deutschland moeglich ist. Hauptaugenmerk wurde auf kleinere Anlagen und Produkte gelegt, weil in diesen Bereichen in Deutschland momentan vordringlich Handlungsbedarf gesehen wird. Im ersten Band sind die Strategien und Massnahmen zur Ozonminderung in den USA (bundesweit) sowie in fuenf Regionen mit besonders hoher Ozonimmissionsbelastung beschrieben. Hierzu erfolgte eine Darstellung der Zustaendigkeitsbereiche auf nationaler, einzelstaatlicher, regionaler und lokaler Ebene, der Gesetzgebung und Regelwerke, der Schwerpunktsetzung hinsichtlich NO{sub x}- und VOC-Minderung und eine kurze Darstellung der quellenbezogenen Massnahmen auf nationaler Ebene und in den betrachteten Regionen. In Band 2 erfolgt eine ausfuehrliche Beschreibung der Massnahmen zur VOC-Emissionsminderung bei Produkten und im gewerblichen Bereich in den USA anhand der nationalen Regelungen fuer Anstrichstoffe und Konsumgueter, der von der kalifornischen Luftreinhaltebehoerde erlassenen VOC-bezogenen Regelungen fuer Anstrichstoffe, Konsumgueter und Gewerbebetriebe sowie der Regelungen des suedkalifornischen South Coast Air Quality Management Districts (Los Angeles und Umgebung). Zur Darstellung der regionalen Bestimmung wurde diese Region ausgewaehlt, da die Regelungen dort aufgrund der besonders hohen Immissionsbelastung

  10. Evaluation of BD MAX Staph SR Assay for Differentiating Between Staphylococcus aureus and Coagulase-Negative Staphylococci and Determining Methicillin Resistance Directly From Positive Blood Cultures.

    Science.gov (United States)

    Lee, Jaewoong; Park, Yeon Joon; Park, Dong Jin; Park, Kang Gyun; Lee, Hae Kyung

    2017-01-01

    We evaluated the performance of the BD MAX StaphSR Assay (SR assay; BD, USA) for direct detection of Staphylococcus aureus and methicillin resistance not only in S. aureus but also in coagulase-negative Staphylococci (CNS) from positive blood cultures. From 228 blood culture bottles, 103 S. aureus [45 methicillin-resistant S. aureus (MRSA), 55 methicillin-susceptible S. aureus (MSSA), 3 mixed infections (1 MRSA+Enterococcus faecalis, 1 MSSA+MRCNS, 1 MSSA+MSCNS)], and 125 CNS (102 MRCNS, 23 MSCNS) were identified by Vitek 2. For further analysis, we obtained the cycle threshold (Ct) values from the BD MAX system software to determine an appropriate cutoff value. For discrepancy analysis, conventional mecA/mecC PCR and oxacillin minimum inhibitory concentrations (MICs) were determined. Compared to Vitek 2, the SR assay identified all 103 S. aureus isolates correctly but failed to detect methicillin resistance in three MRSA isolates. All 55 MSSA isolates were correctly identified by the SR assay. In the concordant cases, the highest Ct values for nuc, mecA, and mec right-extremity junction (MREJ) were 25.6, 22, and 22.2, respectively. Therefore, we selected Ct values from 0-27 as a range of positivity, and applying this cutoff, the sensitivity/specificity of the SR assay were 100%/100% for detecting S. aureus, and 97.9%/98.1% and 99.0%/95.8% for detecting methicillin resistance in S. aureus and CNS, respectively. We propose a Ct cutoff value for nuc/mec assay without considering MREJ because mixed cultures of MSSA and MRCNS were very rare (0.4%) in the positive blood cultures.

  11. Long-term stability of human genomic and human papillomavirus DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media.

    Science.gov (United States)

    Agreda, Patricia M; Beitman, Gerard H; Gutierrez, Erin C; Harris, James M; Koch, Kristopher R; LaViers, William D; Leitch, Sharon V; Maus, Courtney E; McMillian, Ray A; Nussbaumer, William A; Palmer, Marcus L R; Porter, Michael J; Richart, Gregory A; Schwab, Ryan J; Vaughan, Laurence M

    2013-08-01

    We evaluated the effect of storage at 2 to 8°C on the stability of human genomic and human papillomavirus (HPV) DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media. DNA retained the ability to be extracted and PCR amplified for more than 2.5 years in both medium types. Prior inability to detect DNA in archived specimens may have been due to failure of the extraction method to isolate DNA from fixed cells.

  12. Long-Term Stability of Human Genomic and Human Papillomavirus DNA Stored in BD SurePath and Hologic PreservCyt Liquid-Based Cytology Media

    Science.gov (United States)

    Agreda, Patricia M.; Beitman, Gerard H.; Gutierrez, Erin C.; Harris, James M.; Koch, Kristopher R.; LaViers, William D.; Leitch, Sharon V.; Maus, Courtney E.; McMillian, Ray A.; Nussbaumer, William A.; Palmer, Marcus L. R.; Porter, Michael J.; Richart, Gregory A.; Schwab, Ryan J.

    2013-01-01

    We evaluated the effect of storage at 2 to 8°C on the stability of human genomic and human papillomavirus (HPV) DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media. DNA retained the ability to be extracted and PCR amplified for more than 2.5 years in both medium types. Prior inability to detect DNA in archived specimens may have been due to failure of the extraction method to isolate DNA from fixed cells. PMID:23678069

  13. Search for Bs->mu+mu- and Bd->mu+mu- Decays in ppbar Collisions at $\\sqrt{s}$=1.96 TeV

    CERN Document Server

    Acosta, D; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barker, G J; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chapman, J; Chen, C; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chuang, S; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A G; Clark, D; Coca, M; Connolly, A; Convery, M; Conway, J; Cordelli, M; Cortiana, G; Cranshaw, J; Cuevas-Maestro, J; Culbertson, R; Currat, C; Cyr, D; D'Auria, S; D'Onofrio, M; Da Ronco, S; Dagenhart, D; De Barbaro, P; De Cecco, S; De Lentdecker, G; De Pedis, D; Dell'Agnello, S; Dell'Orso, Mauro; Demers, S; Demortier, L; Deninno, M; Derwent, P F; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donega, M; Dorigo, T; Drollinger, V; Ebina, K; Eddy, N; Ely, R; Erbacher, R; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fujii, Y; Furic, I; Gajjar, A; Gallas, A; Gallinaro, M; Galyardt, J; Garcia-, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D W; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giurgiu, G; Glagolev, V; Glenzinski, D A; Gold, M; Goldschmidt, N; Goldstein, D; Goldstein, J; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Grosso-Pilcher, C; Guimarães da Costa, J; Gómez, G; Gómez-Ceballos, G; Günther, M; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Handler, R; Happacher, F; Hara, K; Hare, M; Harr, R F; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heider, E; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Hill, C; Hirschbuehl, D; Hoffman, K D; Holloway, A; Hou, S; Houlden, M A; Huang, Y; Huffman, B T; Hughes, R E; Huston, J; Höcker, A; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kato, Y; Kemp, Y; Kephart, R D; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, J; Lancaster, M; Lander, R; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lecci, C; Lee, J; Lee, S W; Leonardo, N; Leone, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lukens, P; Lyons, L; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Manca, G; Marginean, R; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Moggi, N; Mohr, B; Moore, R; Morello, M; Moulik, T; Mukherjee, A; Mulhearn, M; Mumford, R; Munar, A; Murat, P; Müller, T; Nachtman, J; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Naumov, D V; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Newman-Holmes, C; Nicollerat, A S; Niell, F; Nielsen, J; Nigmanov, T; Nodulman, L; Ogawa, T; Oh, S; Oh, Y D; Ohsugi, T; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Pagliarone, C; Palmonari, F; Paoletti, R; Papadimitriou, V; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pellett, D; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K T; Plager, C; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Pronko, A G; Proudfoot, J; Ptohos, F; Punzi, G; Rademacker, J; Rakitine, A; Rappoccio, S; Ratnikov, F; Ray, H; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Safonov, A; Saint-Denis, R; Sakumoto, W K; Salamanna, G; Saltzberg, D; Sansoni, A; Santi, L; Sarkar, S; Sato, K; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Sciveres; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Siket, M; Sill, A; Sinervo, P; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Squillacioti, P; Stadie, H; Stefanini, A; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Sánchez, C; Taffard, A C; Tafirout, R; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tapprogge, Stefan; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Trischuk, W; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A W; Varganov, A; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Volobuev, I P; Von der Mey, M; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Worcester, M; Worm, S; Wright, T; Wu, X; Wyatt, A; Würthwein, F; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yeh, G P; Yi, K; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zsenei, A; Zucchelli, S; Österberg, K

    2004-01-01

    We report on a search for Bs->mu+mu- and Bd->mu+mu- decays in ppbar collisions at $\\sqrt{s}$=1.96 TeV using 171 pb-1 of data collected by the CDF II experiment at the Fermilab Tevatron Collider. The decay rates of these rare processes are sensitive to contributions from physics beyond the Standard Model. One event survives all our selection requirements,consistent with the background expectation. We derive branching ratio limits of BR(Bs->mu+mu-) mu+mu-) < 1.5 x 10^-7 at 90% confidence level.

  14. Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD).

    Science.gov (United States)

    Wood, David M; Brailsford, Alan D; Dargan, Paul I

    2011-01-01

    Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues.

  15. Substitution of the CFCs R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigerating, air-conditioning and heat pump systems with refrigerants of low ozone depletion potential in the Federal Republic of Germany. Status report; Ersatz der FCKW R11, R13, R503, R13B1, R113, R114, und R12B1 in bestehenden Kaelte-, Klima- und Waermepumpenanlagen in der Bundesrepublik Deutschland durch Kaeltemittel mit geringem Ozonabbaupotential. Statusbericht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-01

    The technical basics and the state of the art for the substitution of the CFC refrigerants R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigeration systems are described and explained. The report contains an overview of the current applications of these refrigerants in the FRG, a review and discussion of existing substitutes, the presentation and evaluation of research and experiences with the conversion to alternative refrigerants, the presentation of the required infrastructure and a discussion of the technical feasibility. The conversion of existing systems to refrigerants of lower ozone depletion potential is in conclusion evaluated with regard to its technical feasibility, environmental relevance and economic efficiency. (orig.) [Deutsch] Es werden die technischen Grundlagen und der Stand der Technik zum Ersatz der FCKW-Kaeltemittel R11, R13, R503, R13B1, R113, R114 und R12B1 in bestehenden Kaelteanlagen dargestellt und erlaeutert. Der Bericht beinhaltet einen Ueberblick ueber die derzeitige Anwendung dieser Kaeltemittel in der BRD, die Vorstellung und Diskussion existierender Ersatzstoffe, die Darstellung und Bewertung der Forschung und Erfahrungen zu Umruestungen auf Ersatzstoffe, die Vorstellung der erforderlichen Infrastruktur und die Diskussion der technischen Durchfuehrbarkeit. Die Umstellung bestehender Anlagen auf Kaeltemittel mit geringerem Ozonabbaupotential wird abschliessend hinsichtlich der technischen Durchfuehrbarkeit, der Umweltrelevanz und der Wirtschaftlichkeit bewertet. (orig.)

  16. Development of a benthic diatom index of biotic integrity (BD-IBI) for ecosystem health assessment of human dominant subtropical rivers, China.

    Science.gov (United States)

    Tan, Xiang; Ma, Peiming; Bunn, Stuart E; Zhang, Quanfa

    2015-03-15

    As efforts intensify to address the issues of declining water quality and biodiversity losses in freshwater ecosystems, there have been great demands for effective methods of evaluating aquatic ecosystem health. In this study, benthic algae assemblages and water quality variables were analyzed to develop a benthic diatom-based index of biotic integrity (BD-IBI) for assessment of the aquatic environment in the upper Han River (China). Through the use of multivariate and multimetric approaches, four metrics - % prostrate individuals, % Amphora individuals, % polysaprob species, and diatom-based eutrophication/pollution index (EPI-D) - were identified from 98 candidate metrics to develop a BD-IBI. Application of the index revealed that water quality in 11% of the 31 sampled sites could be described as excellent condition, in 43% of the sites it could be described as good condition, in 25% as moderate condition, and in 21% as poor condition. The assessment further revealed that the main reason for degradation of the Han river ecosystem was nutrient enrichment through agricultural land use.

  17. Effect of cytochalasin B on 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose handling by BRIN-BD11 cells.

    Science.gov (United States)

    Cetik, Sibel; Rzajeva, Aigun; Malaisse, Willy J; Sener, Abdullah

    2014-07-01

    The present study aimed to investigate the effects of cytochalasin B (20 μM) on the uptake of 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose (8.3 mM each) by BRIN-BD11 cells. Taking into account the distribution space of tritiated water ((3)HOH), which was unexpectedly increased shortly after exposure of the cells to cytochalasin B and then progressively returned to its control values, and that of L-[1-(14)C]glucose, used as an extracellular marker, it was demonstrated that cytochalasin B caused a modest, but significant inhibition of the uptake of D-glucose and its non-metabolized analog by the BRIN-BD11 cells. These findings resemble those observed in acinar or ductal cells of the rat submaxillary gland and displayed a relative magnitude comparable to that found for the inhibition of D-glucose metabolism by cytochalasin B in purified pancreatic islet B cells. These findings reinforce the view that the primary site of action of cytochalasin B is located at the level of the plasma membrane.

  18. Metabolic engineering of Pediococcus acidilactici BD16 for production of vanillin through ferulic acid catabolic pathway and process optimization using response surface methodology.

    Science.gov (United States)

    Kaur, Baljinder; Chakraborty, Debkumar; Kumar, Balvir

    2014-10-01

    Occurrence of feruloyl-CoA synthetase (fcs) and enoyl-CoA hydratase (ech) genes responsible for the bioconversion of ferulic acid to vanillin have been reported and characterized from Amycolatopsis sp., Streptomyces sp., and Pseudomonas sp. Attempts have been made to express these genes in Escherichia coli DH5α, E. coli JM109, and Pseudomonas fluorescens. However, none of the lactic acid bacteria strain having GRAS status was previously proposed for heterologous expression of fcs and ech genes for production of vanillin through biotechnological process. Present study reports heterologous expression of vanillin synthetic gene cassette bearing fcs and ech genes in a dairy isolate Pediococcus acidilactici BD16. After metabolic engineering, statistical optimization of process parameters that influence ferulic acid to vanillin biotransformation in the recombinant strain was carried out using central composite design of response surface methodology. After scale-up of the process, 3.14 mM vanillin was recovered from 1.08 mM ferulic acid per milligram of recombinant cell biomass within 20 min of biotransformation. From LCMS-ESI spectral analysis, a metabolic pathway of phenolic biotransformations was predicted in the recombinant P. acidilactici BD16 (fcs (+)/ech (+)).

  19. Budesrepublik Deutschland teelahkmel / Vello Saarme

    Index Scriptorium Estoniae

    Saarme, Vello

    2004-01-01

    Saksamaa Liitvabariigi presidendi Horst Köhleri kiirvisiidist Tallinna, Välisminister Joschka Fischeri Pärnu-külastusest. Ka Saksamaa suurimast kristlik-demokraatide opositsiooniparteist CDU, mille eesotsas on Angela Merkel

  20. Schadstoffe in Elbefischen - Belastung und Vermarktungsfähigkeit

    OpenAIRE

    1996-01-01

    Fragen, die die Gewässerökologie und die Gewässergütesituation der Elbe betreffen, werden in der Bundesrepublik Deutschland einvernehmlich in der Arbeitsgemeinschaft für die Reinhaltung der Elbe (ARGE ELBE) der sieben Elbanrainerländer behandelt. Die Wassergütestelle Elbe (WGE) koordiniert als gemeinsame Einrichtung der ARGE ELBE die Überwachung des Stromes in den vier Kompartimenten Wasser, Schwebstoffe, Sediment und Biota. Im Rahmen der Biota-Untersuchungen wird auch die Belastungssituation...

  1. Elucidating the origin of the ExbBD components of the TonB system through Bayesian inference and maximum-likelihood phylogenies.

    Science.gov (United States)

    Marmon, Livingstone

    2013-12-01

    Uptake of ferric siderophores, vitamin B12, and other molecules in gram-negative bacteria is mediated by a multi-protein complex known as the TonB system. The ExbB and ExbD protein components of the TonB system play key energizing roles and are homologous with the flagellar motor proteins MotA and MotB. Here, the phylogenetic relationships of ExbBD and MotAB were investigated using Bayesian inference and the maximum-likelihood method. Phylogenetic trees of these proteins suggest that they are separated into distinct monophyletic groups and have originated from a common ancestral system. Several horizontal gene transfer events for ExbB-ExbD are also inferred, and a model for the evolution of the TonB system is proposed. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Five Years' Evaluation of the BD ProbeTec System for the Direct Molecular Detection of Mycobacterium tuberculosis Complex in Respiratory and Nonrespiratory Clinical Samples.

    Science.gov (United States)

    Bicmen, Can; Karaman, Onur; Gunduz, Ayriz T; Erer, Onur F; Coskun, Meral; Kaftan, Osman; Demirel, Mahmut M; Senol, Gunes; Akarca, Tulay; Dereli, Sevket; Ozsoz, Ayse

    2015-01-01

    In this study, Mycobacterium tuberculosis complex was detected by BD ProbeTec ET system in 4716 respiratory and 167 nonrespiratory samples [mostly (98%) smear negative). Sensitivity, specificity, positive and negative predictive values were 81.8%, 98.3, 85.1 and 97.9 for respiratory and 100%, 96.2, 64.7 and 100, for nonrespiratory samples, respectively. Among 149 (3.1%) ProbeTec DTB positive and culture negative samples, 72 (65 respiratory and seven nonrespiratory) (48.3%) were recovered from the patients who were evaluated as having TB infection. The system has been found as useful in early diagnosis of tuberculosis infection in association with the clinical, radiological and histopathological findings.

  3. B-D试验监测失败原因分析%Analysis on causes of failure in B-D test monitoring

    Institute of Scientific and Technical Information of China (English)

    范立; 董翠玲

    2010-01-01

    @@ B-D 试验即布维-狄克试验(Bowie-Dicktest),目的是监测预真空或脉动真空压力蒸汽灭菌器内冷空气排出效果.依照相关规定要求,预真空或脉动真空压力蒸汽灭菌器每日使用前均需做B-D试验,在监测合格的基础上方可进行正式灭菌操作.为观察B-D试验实际意义,提高B-D试验的成功率,对本科2006-2008年连续3年B-D试验结果进行了统计分析,以改进B-D试验质量.

  4. Multicenter Evaluation of BD Max Enteric Parasite Real-Time PCR Assay for Detection of Giardia duodenalis, Cryptosporidium hominis, Cryptosporidium parvum, and Entamoeba histolytica

    Science.gov (United States)

    Relich, R. F.; Doyle, L.; Espina, N.; Fuller, D.; Karchmer, T.; Lainesse, A.; Mortensen, J. E.; Pancholi, P.; Veros, W.; Harrington, S. M.

    2016-01-01

    Common causes of chronic diarrhea among travelers worldwide include protozoan parasites. The majority of parasitic infections are caused by Giardia duodenalis, Entamoeba histolytica, Cryptosporidium parvum, and Cryptosporidium hominis. Similarly, these species cause the majority of parasitic diarrhea acquired in the United States. Detection of parasites by gold standard microscopic methods is time-consuming and requires considerable expertise; enzyme immunoassays and direct fluorescent-antibody (DFA) stains have lowered hands-on time for testing, but improvements in sensitivity and technical time may be possible with a PCR assay. We performed a clinical evaluation of a multiplex PCR panel, the enteric parasite panel (EPP), for the detection of these common parasites using the BD Max instrument, which performs automated extraction and amplification. A total of 2,495 compliant specimens were enrolled, including 2,104 (84%) specimens collected prospectively and 391 (16%) specimens collected retrospectively. Approximately equal numbers were received in 10% formalin (1,273 specimens) and unpreserved (1,222 specimens). The results from the EPP were compared to those from alternate PCR and bidirectional sequencing (APCR), as well as DFA (G. duodenalis and C. parvum or C. hominis) or trichrome stain (E. histolytica). The sensitivity and specificity for prospective and retrospective specimens combined were 98.2% and 99.5% for G. duodenalis, 95.5% and 99.6 for C. parvum or C. hominis, and 100% and 100% for E. histolytica, respectively. The performance of the FDA-approved BD Max EPP compared well to the reference methods and may be an appropriate substitute for microscopic examination or immunoassays. PMID:27535690

  5. Development of CO{sub 2} emissions in Germany in 2015. Another blow to the achievement of objectives in 2020; Entwicklung der CO{sub 2}-Emissionen in Deutschland im Jahr 2015. Ein weiterer Daempfer fuer die Zielerreichung 2020

    Energy Technology Data Exchange (ETDEWEB)

    Ziesing, Hans-Joachim

    2016-05-15

    In 2015, the total CO{sub 2} emissions increased slightly in Germany. Compared to last year they were around 0.6% (5 million tonnes) higher. Conversely, they are temperature-adjusted 0.7% (5 million tonnes) declined. The emissions of all greenhouse gases are expected in 2015 by around 0.8% (7 million tonnes) increased or temperature-adjusted by 0.3% (3 million tonnes) have decreased. Even considering the temperature-adjusted values of the 2020 the targeted destination path is clearly missed. To that the greenhouse gas emissions would have to fall at least by about 3% in the year, 2015. The climate policy action has thus become rather more urgent. [German] Im Jahr 2015 sind die gesamten CO{sub 2}-Emissionen in Deutschland leicht gestiegen. Gegenueber dem Vorjahr waren sie um etwa 0,6 % (5 Mio. t) hoeher. Umgekehrt sind sie temperaturbereinigt um 0,7 % (5 Mio. t) gesunken. Die Emissionen aller Treibhausgase duerften 2015 um rund 0,8 % (7 Mio. t) zugenommen bzw. temperaturbereinigt um 0,3 % (3 Mio. t) abgenommen haben. Auch gemessen an den temperaturbereinigten Werten wird der bis 2020 angestrebte Zielpfad deutlich verfehlt. Dazu haetten die Treibhausgasemissionen im Jahr 2015 mindestens um rund 3 % sinken muessen. Der klimaschutzpolitische Handlungsbedarf ist damit eher noch dringlicher geworden.

  6. Emission control measures for precursors of tropospheric ozone. Pt. 1 and 2; Emissionsminderungsmoeglichkeiten bei Vorlaeufersubstanzen von bodennahem Ozon. Bd. 1: Systemanalyse der Ozonminderungsmassnahmen in den USA. Bd. 2: Luftreinhaltemassnahmen in den USA zur Minderung von VOC-Emissionen aus Kleinanlagen und Produkten und Vergleich mit europaeischen Regelungen

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, T.; Schiefer, C.; Bergmann, S.; Hrabovski, Z. [Institut fuer Umwelttechnologie und Umweltanalytik e.V. (IUTA), Duisburg (Germany)

    1998-08-01

    emissions are compared and discussed. Advantages and disadvantages of the described strategies are highlighted. Based on the actual VOC emission inventory of Germany suggestions for future reduction measures are supposed. (orig.) [Deutsch] In den USA liegen Erfahrungen aus der Ozonbekaempfung ueber einen Zeitraum von 20 bis 30 Jahren vor. Aufgrund besonders hoher Ozonbelastungen in vielen Regionen werden grosse Anstrengungen zur VOC-Minderung unternommen. Wesentliches Ziel des Vorhabens war es, die Schwerpunkt im Hinblick auf die Minderung von VOC-Emissionen herauzufinden und zu pruefen, ob und inwieweit eine Uebertragung von Strategien und Massnahmen auf die Verhaeltnisse in Deutschland moeglich ist. Hauptaugenmerk wurde auf kleinere Anlagen und Produkte gelegt, weil in diesen Bereichen in Deutschland momentan vordringlich Handlungsbedarf gesehen wird. Im ersten Band sind die Strategien und Massnahmen zur Ozonminderung in den USA (bundesweit) sowie in fuenf Regionen mit besonders hoher Ozonimmissionsbelastung beschrieben. Hierzu erfolgte eine Darstellung der Zustaendigkeitsbereiche auf nationaler, einzelstaatlicher, regionaler und lokaler Ebene, der Gesetzgebung und Regelwerke, der Schwerpunktsetzung hinsichtlich NO{sub x}- und VOC-Minderung und eine kurze Darstellung der quellenbezogenen Massnahmen auf nationaler Ebene und in den betrachteten Regionen. In Band 2 erfolgt eine ausfuehrliche Beschreibung der Massnahmen zur VOC-Emissionsminderung bei Produkten und im gewerblichen Bereich in den USA anhand der nationalen Regelungen fuer Anstrichstoffe und Konsumgueter, der von der kalifornischen Luftreinhaltebehoerde erlassenen VOC-bezogenen Regelungen fuer Anstrichstoffe, Konsumgueter und Gewerbebetriebe sowie der Regelungen des suedkalifornischen South Coast Air Quality Management Districts (Los Angeles und Umgebung). Zur Darstellung der regionalen Bestimmung wurde diese Region ausgewaehlt, da die Regelungen dort aufgrund der besonders hohen Immissionsbelastung

  7. Validation of a Multiplex Real-Time PCR Assay for Detection of Mycobacterium spp., Mycobacterium tuberculosis Complex, and Mycobacterium avium Complex Directly from Clinical Samples by Use of the BD Max Open System.

    Science.gov (United States)

    Rocchetti, Talita T; Silbert, Suzane; Gostnell, Alicia; Kubasek, Carly; Widen, Raymond

    2016-06-01

    A multiplex real-time PCR was validated on the BD Max open system to detect different Mycobacterium tuberculosis complex, Mycobacterium avium complex, and Mycobacterium spp. directly from clinical samples. The PCR results were compared to those with traditional cultures. The multiplex PCR assay was found to be a specific and sensitive method for the rapid detection of mycobacteria directly from clinical specimens.

  8. Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI Biotyper and the BD Phoenix system.

    Science.gov (United States)

    Wimmer, Jana L; Long, S Wesley; Cernoch, Patricia; Land, Geoffrey A; Davis, James R; Musser, James M; Olsen, Randall J

    2012-07-01

    Decreasing the time to species identification and antibiotic susceptibility determination of strains recovered from patients with bacteremia significantly decreases morbidity and mortality. Herein, we validated a method to identify Gram-negative bacteria directly from positive blood culture medium using the Bruker MALDI Biotyper and to rapidly perform susceptibility testing using the BD Phoenix.

  9. Gamma-Hydroxybutyrate (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) reduce the volume of cerebral infarction in rodent transient middle cerebral artery occlusion.

    Science.gov (United States)

    Sadasivan, Shankar; Maher, Timothy J; Quang, Lawrence S

    2006-08-01

    gamma-Hydroxybutyric acid (GHB), an endogenous organic acid catabolite of gamma-aminobutyric acid (GABA), has been shown to have tissue-protective effects in various organs, including the brain. We examined the potential neuroprotective effect of GHB and its chemical precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), in the rodent ischemic stroke model by intraluminal filament middle cerebral artery occlusion (MCAO). Adult male Sprague-Dawley rats underwent transient left-sided MCAO and received intraperitoneal treatment with 300 mg/kg of GHB, GBL, 1,4-BD, or control vehicle given at 30 min before, as well as 180 and 360 min after the onset of ischemia. Infarct volumes were determined 24 h after MCAO. In transient MCAO, the mean volume of infarction for control rats was 464.4 +/- 17.9 cu.mm versus 273.6 +/- 53.1, 233.3 +/- 44.7, and 275.4 +/- 39.9 cu.mm for rats treated with 1,4-BD (P GBL (P GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO.

  10. Simultaneous determination of gamma-Hydroxybutyrate (GHB) and its analogues (GBL, 1.4-BD, GVL) in whole blood and urine by liquid chromatography coupled to tandem mass spectrometry

    DEFF Research Database (Denmark)

    Johansen, Sys Stybe; Windberg, Charlotte Norup

    2011-01-01

    A simple liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for simultaneous identification and quantification of ¿-hydroxybutyrate (GHB), ¿-butyrolactone (GBL), 1.4-butanediol (1.4-BD), and ¿-valerolactone (GVL) in whole blood from forensic cases...

  11. Educating Juveniles with Disabilities in Correctional Settings. Fifth CCBD Mini-Library Series: Meeting the Diverse Needs of Children and Youth with E/BD--Evidence-Based Programs and Practices.

    Science.gov (United States)

    Gagnon, Joseph Calvin; Mayer, Matthew J.

    This monograph addresses issues in the appropriate education of children and youth with disabilities, especially emotional and/or behavioral disorders, who are in juvenile correctional facilities. An introductory chapter considers the characteristics of students with E/BD in the public schools; educational services in juvenile corrections; and…

  12. The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines.

    Science.gov (United States)

    Burgey, Christine; Kern, Winfried V; Römer, Winfried; Sakinc, Türkan; Rieg, Siegbert

    2015-05-01

    Antimicrobial peptides are multifunctional effector molecules of innate immunity. In this study we investigated whether endothelial cells actively contribute to innate defense mechanisms by expression of antimicrobial peptides. We therefore stimulated human umbilical vein endothelial cells (HUVEC) with inflammatory cytokines, Th17 cytokines, heat-inactivated bacteria, bacterial conditioned medium (BCM) of Staphylococcus aureus and Streptococcus sanguinis, and lipoteichoic acid (LTA). Stimulation with single cytokines induced discrete expression of human β-defensin 3 (hBD3) by IFN-γ or IL-1β and of ribonuclease 7 (RNase7) by TNF-α without any effects on LL-37 gene expression. Stronger hBD3 and RNase7 induction was observed after combined stimulation with IL-1β, TNF-α and IFN-γ and was confirmed by high hBD3 and RNase7 peptide levels in cell culture supernatants. In contrast, Th17 cytokines or stimulation with LTA did not result in AMP production. Moreover, only BCM of an invasive S. aureus bacteremia isolate induced hBD3 in HUVEC. We conclude that endothelial cells actively contribute to prevent dissemination of pathogens at the blood-tissue-barrier by production of AMPs that exhibit microbicidal and immunomodulatory functions. Further investigations should focus on tissue-specific AMP induction in different endothelial cell types, on pathogen-specific induction patterns and potentially involved pattern-recognition receptors of endothelial cells.

  13. JugendSCHUTZ – ja, aber wer und wie? Von Gesetzen, Werten und Ängsten

    Directory of Open Access Journals (Sweden)

    Christian Berger

    2010-11-01

    Full Text Available Wer die Freiheit aufgibt, um Sicherheit zu gewinnen, wird am Ende beides verlieren. (Benjamin Franklin Überlegungen zum Diskurs in der BRD über die Novellierung des Jugendmedienschutz-Staatsvertrages. In unserem Nachbarstaat, der Bundesrepublik Deutschland, wird derzeit heftigst über die Novellierung des Staatsvertrages über den Schutz der Menschenwürde und den Jugendschutz in Rundfunk und Telemedien (kurz: Jugendmedienschutz-Staatsvertrag oder JMStV diskutiert. Die Rechtslage in Deutschland ist etwas anders als in Österreich. Ein Staatsvertrag ist ein Gesetz, das von allen Bundesländern in gleicher Form beschlossen werden muss, damit es bundesweite Geltung erhält.

  14. Environmental management and organisation systems. A critical review; Umweltmanagement- und Organisationssysteme. Eine kritische Durchleuchtung

    Energy Technology Data Exchange (ETDEWEB)

    Schottelius, D. [Anwaltssozietaet Hoffmann, Liebs, Fritsch und Partner, Frankfurt am Main (Germany); Kuepper-Djindjic, C. [Anwaltssozietaet Hoffmann, Liebs, Fritsch und Partner, Frankfurt am Main (Germany)

    1994-11-20

    The FRG is amongst the industrial nations with the tightest, in parts hardly comprehensible network of regulative provisions by laws, statutory orders, administrative regulations as well as technical rules and standards included in the legal system. With regard to the establishment of management and organisation systems until now there are only few statutory provisions in Germany. The article is to critically review developments and to show connections and interactions between property and procedure provisions. (orig.) [Deutsch] Die Bundesrepublik Deutschland gehoert zu den Industrielaendern mit dem dichtesten, in seinen Teilbereichen kaum noch ueber- und durchschaubaren Netz ordnungsrechtlicher Vorgaben durch Gesetze, Rechtsverordnungen, Verwaltungsvorschriften und ins Rechtssystem einbezogene technische Normen und Regelwerken. Hinsichtlich der Einrichtung von Management- und Organisationssystemen hat Deutschland bisher weitgehend auf gesetzliche Vorgaben verzichtet. Der Beitrag soll Entwicklungen kritisch beleuchten sowie Zusammenhaenge und Zusammenwirken zwischen Sach- und Verfahrensvorschriften aufzeigen. (orig.)

  15. Tracking Advanced Planetary Systems (TAPAS) with HARPS-N. III. HD 5583 and BD+15 2375 - two cool giants with warm companions

    Science.gov (United States)

    Niedzielski, A.; Villaver, E.; Nowak, G.; Adamów, M.; Kowalik, K.; Wolszczan, A.; Deka-Szymankiewicz, B.; Adamczyk, M.; Maciejewski, G.

    2016-04-01

    Context. Evolved stars are crucial pieces for our understanding of the dependency of the planet formation mechanism on the stellar mass and for exploring the mechanism involved in star-planet interactions more deeply. Over the last ten years, we have monitored about 1000 evolved stars for radial velocity variations in the search for low-mass companions under the Penn State - Torun Centre for Astronomy Planet Search program with the Hobby-Eberly Telescope (HET). Selected prospective candidates that required higher RV precision measurements were followed with HARPS-N at the 3.6 m Telescopio Nazionale Galileo under the TAPAS project. Aims: We aim to detect planetary systems around evolved stars to be able to build sound statistics on the frequency and intrinsic nature of these systems, and to deliver in-depth studies of selected planetary systems with evidence of star-planet interaction processes. Methods: For HD 5583 we obtained 14 epochs of precise RV measurements that were collected over 2313 days with the HET, and 22 epochs of ultra-precise HARPS-N data collected over 976 days. For BD+15 2375 we collected 24 epochs of HET data over 3286 days and 25 epochs of HARPS-S data over 902 days. Results: We report the discovery of two planetary mass objects that are orbiting two evolved red giant stars: HD 5583 has a msini = 5.78MJ companion at 0.529 AU in a nearly circular orbit (e = 0.076), the closest companion to a giant star detected with the RV technique, and BD+15 2735 that, with a msini = 1.06MJ, holds the record for the lightest planet orbiting an evolved star found so far (in a circular e = 0.001, 0.576 AU orbit). These are the third and fourth planets found within the TAPAS project, a HARPS-N monitoring of evolved planetary systems identified with the HET. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Stanford University, Ludwig

  16. Daniel Wildmann: Der veränderbare Körper. Jüdische Turner, Männlichkeit und das Wiedergewinnen von Geschichte in Deutschland um 1900. Tübingen: Mohr Siebeck Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Martin Lücke

    2010-03-01

    Full Text Available In seiner körpergeschichtlichen Studie widmet sich Daniel Wildmann nationaljüdischen Turnvereinen in Deutschland im Zeitraum von 1898 bis 1921. Er zeichnet nach, wie sich der Entwurf eines jüdischen Turnkollektivs in politischen Auseinandersetzungen im Spannungsfeld von Zionismus und Antisemitismus im deutschen Kaiserreich verorten lässt und an welche medizinischen Diskurse die Debatten um eine körperlich-therapeutische Wirkung von Turnen anknüpften. Schwerpunkt seiner Arbeit ist jedoch das Herausarbeiten der geschlechtlichen Kodierung der jüdischen turnenden Männer- und Frauenkörper. Hier zeigt Wildmann, dass insbesondere eine eigensinnige Aneignung und Umdeutung von Vorstellungen der jüdischen Antike sowie Körperbilder einer Offiziers-Männlichkeit die Vorstellung von idealer jüdischer Männlichkeit prägten.In his study, which is informed by discourses on the history of the body, Daniel Wildmann examines national Jewish gymnastics clubs in Germany during the period from 1898 to 1921. He traces the manner in which we can locate the model of a Jewish gymnastics collective within the political debates found in the field of tension between Zionism and anti-Semitism during the German empire. Further, he pursues the question as to which medical discourses and debates connect to the physical-therapeutic effects of gymnastics. The focus of his work is, however, to address the gendered coding of Jewish gymnasts’ bodies, both male and female. Here, Wildmann shows that the conception of an ideal Jewish masculinity is determined in particular by a persistent appropriation and reinterpretation of ideas found in Jewish antiquity as well as masculine body images perpetuated by officers.

  17. Fracking in the conflict area between energy and environmental policy. The discussion in Germany and the Netherlands by comparison; Fracking im Spannungsfeld zwischen Energie- und Umweltpolitik. Die Diskussion in Deutschland und den Niederlanden im Vergleich

    Energy Technology Data Exchange (ETDEWEB)

    Kontny, Kerstin

    2016-11-01

    The shale gas production using the so-called fracking method represents for opponents the use of a high-risk technology. Proponents see it, however a technological advance, and the answer to current energy issues. For the citizens of a country, the debate involves mainly uncertainties, the technology is still associated with risks that are not only difficult to assess for the layman. Due to these uncertainties, there is a danger that scientific evidence for political purposes are exploited. Particularly exciting is therefore the question of how the subject is discussed in different countries. In Fracking in the conflict area between energy and environmental policies are the debates in natural gas country Netherlands and the country of energy transition, Germany are compared. Kerstin Kontry's research put emphasis on the parties to the debate actors, the course of the debate and the issues are discussed. The main question is to what extent the discussions are shaped by national factors. [German] Die Schiefergasfoerderung mit Hilfe der sogenannten Fracking-Methode stellt fuer Gegner die Anwendung einer Hochrisikotechnologie dar, Befuerworter sehen darin hingegen einen technologischen Fortschritt und die Antwort auf derzeitige Energiefragen. Fuer die Buerger eines Landes birgt die Debatte vor allem Unsicherheiten, ist die Technologie doch mit Risiken verbunden, die nicht nur fuer den Laien schwer einzuschaetzen sind. Aufgrund dieser Unsicherheiten droht die Gefahr, dass wissenschaftliche Erkenntnisse fuer politische Zwecke instrumentalisiert werden. Besonders spannend ist daher die Frage, wie die Thematik in unterschiedlichen Laendern diskutiert wird. In Fracking im Spannungsfeld zwischen Energie- und Umweltpolitik werden die Debatten im Erdgasland Niederlande und dem Land der Energiewende, Deutschland, verglichen. Den Schwerpunkt legt Kerstin Kontny dabei auf die an der Debatte beteiligten Akteure, den Verlauf der Debatte sowie die behandelten Themen. Dabei

  18. Analyse interreligiöser Begegnung in der Praxis. Kontext, Bedingungen, Strategien und Konsequenzen am Beispiel lebensgeschichtlicher Erzählungen aus einem christlich-muslimischen Begegnungszentrum in Deutschland

    Directory of Open Access Journals (Sweden)

    Mirjam Eva Stricker

    2016-01-01

    Full Text Available Interreligiöse Dialoge im Allgemeinen und christlich-muslimische Dialoge in Deutschland im Besonderen können einen wichtigen Beitrag zum friedlichen Zusammenleben leisten. Gleichzeitig stellen interreligiöse Dialoge einen Ort potenzieller interreligiöser Konflikte dar, was u.a. mit der Beschaffenheit von "Religion" zusammenhängt. Vor dem Hintergrund der gesellschaftlichen Relevanz potenzieller interreligiöser Konflikte und dem (präventiven Umgang damit in konkreten Begegnungssituationen ist das Thema für empirische Untersuchungen von besonderem Interesse. Die hier vorgestellte qualitative Studie hatte daher zum Ziel, einen Zugang zur Alltagspraxis interreligiöser Dialoge zu erlangen und diese Praxis zu analysieren. Mit der anfangs offen gehaltenen Forschungsfrage sollte herausgefunden werden, wie sich interreligiöser Austausch auf persönlicher Ebene gestaltet, wie die Beteiligten diesen wahrnehmen, wie sie in Begegnungssituationen handeln, und welche Überzeugungen sie dabei leiten. Zur Datenerhebung wurden die teilnehmende Beobachtung und narrative Interviews eingesetzt. Das Vorgehen bei der Auswertung leitete sich aus der relationalen Hermeneutik ab, ergänzt durch Kodierverfahren der Grounded-Theory-Methodologie. Die Ergebnisse umfassen den Versuch eines Modells interreligiöser Begegnung. In allen hierzu entwickelten Kategorien lassen sich Bezüge zum Thema "Lernen" herstellen, welches sich als interreligiöses Lernen interpretieren lässt. Daraus kann die begründete Vermutung abgeleitet werden, dass die Befähigung zum interreligiösen Austausch in der Praxis auch erst durch konkrete interreligiöse Begegnungen entstehen kann. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1601174

  19. Reflections on the 22nd Conference of the African Studies Association in Germany (VAD e.V. in Cologne, Germany (30 May–2 June 2012 Reflexionen zur 22. Tagung der Vereinigung für Afrikawissenschaften in Deutschland (VAD e.V. in Köln (30. Mai bis 2. Juni 2012

    Directory of Open Access Journals (Sweden)

    Martina Gockel-Frank

    2013-01-01

    Full Text Available The following article comments on contents and organisation of the 22nd Conference of the African Studies Association in Germany (Vereinigung für Afrikawissenschaften in Deutschland, VAD e.V., which took place from 30 May until 2 June 2012 at the University of Cologne, Germany. Thirty-seven panels and five round tables organised around four thematic foci (land rights, resource management, models of governance, media served as a platform for discussions on developments on the African continent. A complex framework programme dealing with similar topics was open to the public and provided insight into recent research projects and their results.Die Autoren berichten über inhaltliche Schwerpunkte und Ablauf der 22. Tagung der Vereinigung für Afrikawissenschaften in Deutschland (VAD e.V., die vom 30. Mai bis zum 2. Juni 2012 an der Universität zu Köln stattfand. Vier Themenkomplexe (Landrechte, Ressourcennutzung, Regierungsformen und neue Medien wurden in 37 Vortrags- und Diskussionsforen sowie fünf Round-Table-Gesprächen diskutiert. Im Rahmen eines thematisch angepassten umfassenden Rahmenprogramms konnte sich eine interessierte Öffentlichkeit über aktuelle Forschungsprojekte und deren Ergebnisse informieren.

  20. Particle Reduction Strategies - PAREST. Prognosis of air quality and assessment of limit value exceedances in Germany for the reference years 2010, 2015 and 2020; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Prognose der Luftqualitaet und Abschaetzung von Grenzwertueberschreitungen in Deutschland fuer die Referenzjahre 2010, 2015 und 2020. Teilbericht

    Energy Technology Data Exchange (ETDEWEB)

    Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

    2013-06-15

    With the help of a data assimilation technique (optimal interpolation) a comprehensive forecast of O{sub 3}, PM10 and NO{sub 2} air quality in Germany for the years 2010, 2015 and 2020 was prepared. Based on these results, an assessment was made whether the limits of the European Air Quality Directive (2008/50/EC) can be observed in 2015 and 2020. [German] In diesem Bericht wurde mit Hilfe einer Datenassimilationstechnik (Optimale Interpolation) eine flaechendeckende Prognose der O{sub 3}-, PM10- und NO{sub 2}-Luftqualitaet in Deutschland fuer die Jahre 2010, 2015 und 2020 erstellt. Auf Basis dieser Ergebnisse wurde eine Abschaetzung vorgenommen, ob die Grenzwerte der europaeischen Luftqualitaetsrichtlinie (2008/50/EG) im Jahre 2015 und 2020 eingehalten werden koennen. Weiterhin wurde untersucht, was die in der Luftqualitaetsrichtlinie festgelegten Regelungen fuer die Feinstaeube PM2.5 fuer die PM2.5-Belastung in Deutschland bedeuten und ob das nationale Ziel fuer die Reduktion der PM2.5-Belastung unter den Emissionsbedingungen des Jahres 2020 erreicht werden kann.

  1. Application of the light-front holographic wavefunction for heavy-light pseudoscalar meson in Bd,s → Dd,sP decays

    Science.gov (United States)

    Chang, Qin; Xu, Shuai; Chen, Lingxin

    2017-08-01

    In this paper we extend our analyses of the decay constant and distribution amplitude with an improved holographic wavefunction to the heavy-light pseudoscalar mesons. In the evaluations, the helicity-dependence of the holographic wavefunction is considered; and an independent mass scale parameter is employed to moderate the strong suppression induced by the heavy quark. Under the constraints from decay constants and masses of pseudoscalar mesons, the χ2-analyses for the holographic parameters exhibit a rough consistence with the results obtained by fitting the Regge trajectory. With the fitted parameters, the results for the decay constants and distribution amplitudes are presented. We then show their application in evaluating the Bd,s →Dd,s P decays, in which the power-suppressed spectator scattering and weak annihilation corrections are first estimated. Numerically, the spectator scattering and weak annihilation corrections present a negative shift of about 0.7% on the branching fractions; while, the predictions are still larger than the experimental data. Such small negative shift confirms the estimation based on the power counting rules.

  2. SU(3) and CP violating weak and strong final state phases for B_{d}^{0} and B_{s}^{0} decays

    CERN Document Server

    Fayyazuddin, A

    2006-01-01

    Using rotation in SU(3) space, a set of relations between various decay modes of B_{d}^{0} and B_{s}^{0} are derived. In particular the decays bar{B}_{d}^{0}->rho ^{+}K^{-}, bar{B}_{s}^{0}-> K^{*^{+}}K^{-} and bar{B}_{d}^{0}-> K^{*^{-}}pi ^{+}, bar{B}_{s}^{0}-> K^{*^{-}}K^{+} are expressed in terms of the decay parameters of bar{B}_{d}^{0}->rho ^{+}pi ^{-},rho ^{-}\\pi ^{+}. From the experimental data, we derive the bounds: 0.12leq r_{-,+}leq 0.28; 0.15\\leq r_{+,-}\\leq 0.38. Further in the range -0.18\\leq z_{-+,+-}leq -0.28 it is possible to get a solution delta _{-,+}=delta_{+,-}=pi -delta ^{prime} for 62^{o} geq delta ^{prime}geq 35^{o} and 53^{o}leq gamma leq 71^{o} However, for 0.25leq z_{+-}leq 0.45 and -0.45\\leq z_{-+}leq -0.25, we get a complementry solution delta_{-+}=pi -delta _{+-}; 50^{o}geq delta_{+-} geq 35^{o} ; 50^{o}leq gamma leq 71^{o}. Assuming factorization for electroweak penguin, we obtain the sum rule f_{rho }-(1/3)f_{omega}-(2/3)f_{phi}=0 which is well satisfied experimentally.

  3. Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.

    Science.gov (United States)

    Zhu, Shanshan; Wang, Chenchen; Han, Yuan; Song, Chao; Hu, Xueming; Liu, Yannan

    2015-01-01

    Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms remain elusive. The aim of this study was to examine the potential role of the spinal sigma-1 receptor in the development of bone cancer pain. Walker 256 mammary gland carcinoma cells were implanted into the intramedullary space of the right tibia of Sprague-Dawley rats to induce ongoing bone cancer-related pain behaviors; our findings indicated that, on days 7, 10, 14, and 21 after operation, the expression of sigma-1 receptor in the spinal cord was higher in BCP rats compared to the sham rats. Furthermore, intrathecal injection of 120 nmol of sigma-1 receptor antagonist BD1047 on days 5, 6, and 7 after operation attenuated mechanical allodynia as well as the associated induction of c-Fos and activation of microglial cells, NR1, and the subsequent Ca(2+)-dependent signals of BCP rats. These results suggest that sigma-1 receptor is involved in the development of bone cancer pain and that targeting sigma-1 receptor may be a new strategy for the treatment of bone cancer pain.

  4. Search for $B_s \\rightarrow \\mu^{+}\\mu^{-}$ and $B_d \\rightarrow \\mu^{+}\\mu^{-}$ decays with the full CDF Run II data set

    CERN Document Server

    Aaltonen, T; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Butti, P; Buzatu, A; Calamba, A; Camarda, S; Campanelli, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chokheli, D; Cho, K; Ciocci, M A; Clark, A; Clarke, C; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Cremonesi, M; Cruz, D; Cuevas, J; Culbertson, R; d'Ascenzo, N; Datta, M; de Barbaro, P; Demortier, L; Deninno, M; d'Errico, M; Devoto, F; Di Canto, A; Di Ruzza, B; Dittmann, J R; Donati, S; D'Onofrio, M; Dorigo, M; Driutti, A; Ebina, K; Edgar, R; Elagin, A; Erbacher, R; Errede, S; Esham, B; Eusebi, R; Farrington, S; Fernandez Ramos, J P; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Frisch, H; Funakoshi, Y; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Goldin, D; Gold, M; Golossanov, A; Gomez-Ceballos, G; Gomez, G; Goncharov, M; Gonzalez Lopez, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gramellini, E; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Han, J Y; Happacher, F; Hara, K; Hare, M; Harrington-Taber, T; Harr, R F; Hatakeyama, K; Hays, C; Heinrich, J; Herndon, M; Hocker, A; Hong, Z; Hopkins, W; Hou, S; Hughes, R E; Husemann, U; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Junk, T R; Jun, S Y; Kambeitz, M; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kimura, N; Kim, Y J; Kim, Y K; Kirby, M; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Kruse, M; Kuhr, T; Kurata, M; Laasanen, A T; Lammel, S; Lancaster, M; Lannon, K; Latino, G; Lee, H S; Lee, J S; Leone, S; Leo, S; Lewis, J D; Limosani, A; Lipeles, E; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lysak, R; Lys, J; Madrak, R; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, P; Martinez, M; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Nigmanov, T; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagliarone, C; Palencia, E; Palni, P; Papadimitriou, V; Parker, W; Pauletta, G; Paulini, M; Paus, C; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Pranko, A; Prokoshin, F; Ptohos, F; Punzi, G; Ranjan, N; Redondo Fernandez, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodriguez, T; Rolli, S; Ronzani, M; Roser, R; Rosner, J L; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schwarz, T; Scodellaro, L; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Song, H; Sorin, V; Sperka, D; Stancari, M; St. Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thomson, E; Thukral, V; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Vazquez, F; Velev, G; Vellidis, C; Vernieri, C; Vidal, M; Vilar, R; Vizan, J; Vogel, M; Volpi, G; Wagner, P; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C, III; Whiteson, D; Wicklund, A B; Wilbur, S; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Zanetti, A M; Zeng, Y; Zhou, C; Zucchelli, S

    2013-01-01

    We report on a search for \\bsmm\\ and \\bdmm\\ decays using proton-antiproton collision data at $\\sqrt{s}=1.96$~TeV corresponding to $10~\\fb$ of integrated luminosity collected by the CDF detector at the Fermilab Tevatron collider. The observed number of \\bd\\ candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of $\\brbdmm < 4.6\\times 10^{-9}$ at 95\\% confidence level. We observe an excess of \\bs\\ candidates. The probability that the background processes alone could produce such an excess or larger is $0.94\\%$. The probability that the combination of background and the expected standard model rate of \\bsmm\\ could produce such an excess or larger is $6.8\\%$. These data are used to determine a branching fraction $\\brbsmm = (1.3^{+0.9}_{-0.7}) \\times 10^{-8} $ and provide an upper limit of $\\brbsmm < 3.1\\times 10^{-8}$ at 95\\% confidence level.

  5. Hairy root induction and phytoremediation of textile dye, Reactive green 19A-HE4BD, in a halophyte, Sesuvium portulacastrum (L. L.

    Directory of Open Access Journals (Sweden)

    Vinayak H. Lokhande

    2015-12-01

    Full Text Available In this study, we report phytoremediation of textile dyes using hairy roots derived through Agrobacterium rhizogenes (NCIM 5140 infection of in vitro leaf and stem explants of a halophyte Sesuvium portulacastrum (L. L. Leaf explants showed higher frequency of hairy root induction (70% than stem explants (30%, and maximum number of roots (leaf 42.3 ± 2.4 and stem 50.3 ± 1.7. Transformed nature of hairy roots was ascertained by amplifying 970 bp region of T-DNA of Ri plasmid. Hairy roots were screened for phytoremediation of various textile dyes and results showed that HRs were able to degrade Reactive green 19A HE4BD upto 98% within 5 days of incubation. Spectrophotometric analysis showed decrease in dye concentration while HPLC and FTIR analysis confirmed its degradation. Seed germination assay demonstrated non-toxic nature of the extracted metabolites. This is the first report on induction of hairy root culture in Sesuvium portulacastrum and phytoremediation of textile dyes.

  6. The Design and Production of the LHCb VELO High Voltage System and Analysis of the Bd ⇒ K*μ+μ- Rare Decay

    CERN Document Server

    Rakotomiaramanana, Barinjaka Mamitiana; Soler, P

    2010-01-01

    LHCb is the dedicated flavour physics experiment of the LHC. The experiment is designed for probing new physics through measurements of CP violation and rare decays. This thesis includes simulation studies of the Bd ⇒ K*μ+μ- decay. The LHCb vertex locator (VELO) is the highest precision tracking detector at the LHC and is used to identify primary and secondary vertices for the identification of the $b$ and $c$ hadrons. The VELO modules contain silicon strip detectors which must be operated under reverse bias voltage. This thesis presents the work performed on the design, production and characterisation of the VELO high voltage system. The VELO operates only 8\\mm~from the LHC beam in a high radiation environment. A future upgrade will require operation at up to 10$^{16}$ n_{eq}cm^{-2}.This thesis presents a characterisation of p-type silicon sensors before and after heavy irradiations. The design of the HV system and the substantial programme of quality assurance tests performed on both the hardware and so...

  7. Search for $B_s \\rightarrow \\mu^{+}\\mu^{-}$ and $B_d \\rightarrow \\mu^{+}\\mu^{-}$ decays with the full CDF Run II data set

    CERN Document Server

    Aaltonen, T.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J.A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V.E.; Barnett, B.A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K.R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H.S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chen, Y.C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Ciocci, M.A.; Clark, A.; Clarke, C.; Convery, M.E.; Conway, J.; Corbo, M..; Cordelli, M.; Cox, C.A.; Cox, D.J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; Devoto, F.; d'Errico, M.; Di Canto, A.; Di Ruzza, B.; Dittmann, J.R.; D'Onofrio, M.; Donati, S.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Eusebi, R.; Farrington, S.; Fernandez Ramos, J.P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J.C.; Frisch, H.; Funakoshi, Y.; Garfinkel, A.F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C.M.; Giokaris, N.; Giromini, P.; Giurgiu, G.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; Gonzalez Lopez, O.; Gorelov, I.; Goshaw, A.T.; Goulianos, K.; Gramellini, E.; Grinstein, S.; Grosso-Pilcher, C.; Group, R.C.; Guimaraes da Costa, J.; Hahn, S.R.; Han, J.Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R.F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R.E.; Husemann, U.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E.J.; Jindariani, S.; Jones, M.; Joo, K.K.; Jun, S.Y.; Junk, T.R.; Kambeitz, M.; Kamon, T.; Karchin, P.E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D.H.; Kim, H.S.; Kim, J.E.; Kim, M.J.; Kim, S.B.; Kim, S.H.; Kim, Y.K.; Kim, Y.J.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D.J.; Konigsberg, J.; Kotwal, A.V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A.T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H.S.; Lee, J.S.; Leo, S.; Leone, S.; Lewis, J.D.; Limosani, A.; Lipeles, E.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Margaroli, F.; Marino, P.; Martinez, M.; Matera, K.; Mattson, M.E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C.S.; Moore, R.; Morello, M.J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S.Y.; Norniella, O.; Oakes, L.; Oh, S.H.; Oh, Y.D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T.J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Prokoshin, F.; Pranko, A.; Ptohos, F.; Punzi, G.; Ranjan, N.; Redondo Fernandez, I.; Renton, P.; Rescigno, M.; Riddick, T.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J.L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Safonov, A.; Sakumoto, W.K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E.E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S.Z.; Shears, T.; Shepard, P.F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sinervo, P.; Sliwa, K.; Smith, J.R.; Snider, F.D.; Sorin, V.; Song, H.; Sperka, D.; Stancari, M.; St. Denis, R.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P.K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vazquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizan, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S.M.; Warburton, A.; Waters, D.; Wester, W.C., III; Whiteson, D.; Wicklund, A.B.; Wilbur, S.; Williams, H.H.; Wilson, J.S.; Wilson, P.; Winer, B.L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U.K.; Yang, Y.C.; Yao, W.M.; Yeh, G.P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G.B.; Yu, I.; Zanetti, A.M.; Zeng, Y.; Zhou, C.; Zucchelli, S.

    2013-01-01

    We report on a search for \\bsmm\\ and \\bdmm\\ decays using proton-antiproton collision data at $\\sqrt{s}=1.96$~TeV corresponding to $10~\\fb$ of integrated luminosity collected by the CDF detector at the Fermilab Tevatron collider. The observed number of \\bd\\ candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of $\\brbdmm < 4.6\\times 10^{-9}$ at 95\\% confidence level. We observe an excess of \\bs\\ candidates. The probability that the background processes alone could produce such an excess or larger is $0.94\\%$. The probability that the combination of background and the expected standard model rate of \\bsmm\\ could produce such an excess or larger is $6.8\\%$. These data are used to determine a branching fraction $\\brbsmm = (1.3^{+0.9}_{-0.7}) \\times 10^{-8} $ and provide an upper limit of $\\brbsmm < 3.1\\times 10^{-8}$ at 95\\% confidence level.

  8. Purification of soybean major allergen Gly m Bd 28K and preparation of its polyclonal antibodies%大豆主要过敏原GlymBd28K的分离纯化及多抗血清的制备

    Institute of Scientific and Technical Information of China (English)

    席俊; 高学梅; 闫慧丽; 陆启玉

    2015-01-01

    The 28K(Gly m Bd 28K)was isolated and purified from defatted soybean flour. Then it was used to prepare the rabbit polyclonal antisera. 28K protein was extracted with an alkali solution and acid formulation. 28K crude protein was attended by ammonium sulfate precipitation method, and then DEAE–Sepharose CL–6B further purified 28K,28K was detected purity by SDS–PAGE electrophoresis,prepared the rabbit polyclonal antiserum,tested antisera titer by indirect ELISA. In the study,28K was successfully purified,the titer of rabbit antisera obtained was up to 1∶51200,and rabbit antisera were prepared. That might provide a basis for the study on major allergens of soybean protein 28K monoclonal antibody and 28K IgG determine.%该文从脱脂大豆粉中分离纯化28K(Gly m Bd 28K)蛋白,并制备多抗血清。方法用碱溶酸提法提取28K蛋白,盐析法制得28K粗蛋白,DEAE–Sepharose CL–6B层析纯化28K蛋白, SDS–聚丙烯酰胺凝胶电泳检测蛋白的纯度,制备兔抗血清,用间接ELISA法检测效价。该实验纯化出28K蛋白,制备了抗28K的多抗血清,效价为1∶51200。为研究大豆主要过敏原蛋白28K的单克隆抗体制备及28K的IgG结合表位的确定奠定了基础。

  9. Baden-Wuerttemberg. Energy report 2001; Baden-Wuerttemberg. Energie-Bericht 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The energy report reviews the energy policy of the Land Baden-Wuerttemberg in the light of the national and international situation in the year under report. Tables and diagrams present data and information on the energy sector in Baden-Wuerttemberg: energy consumption in this Land in comparison to the consumption in the Federal Republic of Germany; primary energy consumption; end-use energy consumption; rational use of energy; mineral oil; coal; electricity; natural gas; district heating; preliminary primary energy consumption on the national scale. The annex shows the energy balance of Baden-Wuerttemberg for the past year. (orig.) [German] Der Energiebericht gibt einen Ueberblick ueber die Energiepolitk Baden-Wuerttembergs im nationalen und internationalen Rahmen fuer das Berichtsjahr. Tabellen und Graphiken informieren ueber die wichtigsten Daten zur Energieversorgung des Landes: Energieverbrauch in Baden-Wuerttemberg und im Vergleich zur Bundesrepublik Deutschland; Primaerenergieverbrauch; Endenergieverbrauch; rationelle Nutzung von Energie; Mineraloel; Kohle; Strom; Erdgas; Fernwaerme; vorlaeufiger Primaerenergieverbrauch in der Bundesrepublik Deutschland. Der Anhang enthaelt die Energiebilanz Baden-Wuerttemberg fuer das Vorjahr. (orig.)

  10. Synergistic anti-inflammatory activity of the antimicrobial peptides human beta-defensin-3 (hBD-3 and cathelicidin (LL-37 in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts.

    Directory of Open Access Journals (Sweden)

    Telma Blanca Lombardo Bedran

    Full Text Available Given the spread of antibiotic resistance in bacterial pathogens, antimicrobial peptides that can also modulate the immune response may be a novel approach for effectively controlling periodontal infections. In the present study, we used a three-dimensional (3D co-culture model of gingival epithelial cells and fibroblasts stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS to investigate the anti-inflammatory properties of human beta-defensin-3 (hBD-3 and cathelicidin (LL-37 and to determine whether these antimicrobial peptides can act in synergy. The 3D co-culture model composed of gingival fibroblasts embedded in a collagen matrix overlaid with gingival epithelial cells had a synergistic effect with respect to the secretion of IL-6 and IL-8 in response to LPS stimulation compared to fibroblasts and epithelial cells alone. The 3D co-culture model was stimulated with non-cytotoxic concentrations of hBD-3 (10 and 20 µM and LL-37 (0.1 and 0.2 µM individually and in combination in the presence of A. actinomycetemcomitans LPS. A multiplex ELISA assay was used to quantify the secretion of 41 different cytokines. hBD-3 and LL-37 acted in synergy to reduce the secretion of GRO-alpha, G-CSF, IP-10, IL-6, and MCP-1, but only had an additive effect on reducing the secretion of IL-8 in response to A. actinomycetemcomitans LPS stimulation. The present study showed that hBD-3 acted in synergy with LL-37 to reduce the secretion of cytokines by an LPS-stimulated 3D model of gingival mucosa. This combination of antimicrobial peptides thus shows promising potential as an adjunctive therapy for treating inflammatory periodontitis.

  11. Benchmarking Compound Methods (CBS-QB3, CBS-APNO, G3, G4, W1BD) against the Active Thermochemical Tables: Formation Enthalpies of Radicals.

    Science.gov (United States)

    Somers, Kieran P; Simmie, John M

    2015-08-20

    The 298.15 K formation enthalpies of 38 radicals with molecular formula CxHyOz have been computed via the atomization procedure using the five title methods. The computed formation enthalpies are then benchmarked against the values recommended in the Active Thermochemical Tables (ATcT). The accuracy of the methods have been interpreted in terms of descriptive statistics, including the mean-signed error, mean-unsigned error, maximum average deviation, 2σ uncertainties, and 2×root-mean-square-deviations (2RMSD). The results highlight the following rank order of accuracy for the methods studied G4 > G3 > W1BD > CBS-APNO > CBS-QB3. The findings of this work are also considered in light of a recent companion study, which took an identical approach to quantifying the accuracies of these methods for 48 closed-shell singlet CxHyOz compounds. A similar order of accuracies and precisions were observed therein: G3 > G4 > W1BD > CBS-APNO > CBS-QB3. Both studies highlight systematic biases/deviations from the ATcT for the methods investigated, which are discussed in some detail, with methods having clear tendencies to over- or underpredict the recommended formation enthalpies for radical and/or closed-shell CxHyOz compounds. We show that one can improve the accuracy of their computation, and simultaneously reduce the uncertainty, by taking unweighted average formation enthalpies from various combinations of methods used. The reader should note that the statistical analyses preceding these conclusions also highlight that these error cancellation effects are unique for closed-shell and radical species. By extension, these error-cancellation effects can be expected to be different for various homologous series and chemical functionalities and their closed- and open-shell subgroups. Hence, further benchmarking studies are advised for other homologous series, such that the scientists and engineers (e.g., combustion/atmospheric/astrochemical) who frequently use these methods can

  12. Recoding of the stop codon UGA to glycine by a BD1-5/SN-2 bacterium and niche partitioning between Alpha- and Gammaproteobacteria in a tidal sediment microbial community naturally selected in a laboratory chemostat

    Energy Technology Data Exchange (ETDEWEB)

    Hanke, Anna [Max Planck Institute for Marine Microbiology; Hamann, Emmo [Max Planck Institute for Marine Microbiology; Sharma, Ritin [ORNL; Geelhoed, Jeanine [Max Planck Institute for Marine Microbiology; Hargesheimer, Theresa [Max Planck Institute for Marine Microbiology; Kraft, Beate [Max Planck Institute for Marine Microbiology; Meyer, Volker [Max Planck Institute for Marine Microbiology; Lenk, Sabine [Max Planck Institute for Marine Microbiology; Osmers, Harald [Max Planck Institute for Marine Microbiology; Wu, Rong [Delft University of Technology, Delft, Netherlands; Makinwa, Kofi [Delft University of Technology, Delft, Netherlands; Hettich, Robert {Bob} L [ORNL; Banfield, Jillian F. [University of California, Berkeley; Tegetmeyer, Halina [Max Planck Institute for Marine Microbiology; Strouss, Marc [University of Calgary, ALberta, Canada

    2014-01-01

    Sandy coastal sediments are global hot spots for microbial mineralization of organic matter and denitrification. These sediments are characterized by advective pore water flow, tidal cycling and an active and complex microbial community. Metagenomic sequencing of microbial communities sampled from such sediments showed that potential sulfuroxidizing Gammaproteobacteria and members of the enigmaticBD1-5/ SN-2 candidatephylumwereabundantinsitu (>10% and 2% respectively). By mimicking the dynamic oxic/anoxic environmental conditions of the sedimentin a laboratory chemostat, a simplified microbial community was selected from the more complex inoculum. Metagenomics, proteomics and fluorescenceinsituhybridization showed that this simplified community contained both a potential sulfuroxidizing Gamma proteobacteria (at 24 2% abundance) and a member of the BD1-5 / SN-2candidatephylum (at 7 6%abundance). Despite the abundant supply of organic substrates to the chemostat, proteomic analysis suggested that the selected gamma proteobacterium grew partially auto trophically and performed hydrogen/formate oxidation. The enrichment of a member of the BD1-5/SN-2candidatephylum enabled, for the first time, direct microscopic observation by fluorescent insitu hybridization and the experimental validation of the previously predicted translation of the stop codon UGA into glycine.

  13. Affinity composite cryogel discs functionalized with Reactive Red 120 and Green HE 4BD dye ligands: Application on the separation of human immunoglobulin G subclasses

    Energy Technology Data Exchange (ETDEWEB)

    Huseynli, Sabina; Baydemir, Gözde; Sarı, Esma [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey); Elkak, Assem [Laboraory of “Valorisation des Ressources Naturelles et Produits de Santé (VRNPS)”, Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri University Campus, Hadath (Lebanon); Denizli, Adil, E-mail: denizli@hacettepe.edu.tr [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey)

    2015-01-01

    Naturally produced by the human immune system, immunoglobulin nowadays is widely used for in vivo and in vitro purposes. The increased needs for pure immunoglobulin have prompted researchers to find new immunoglobulin chromatographic separation processes. Cryogels as chromatographic adsorbents, congregate several mechanical features including good compatibility, large pore structure, flexibility, short diffusion pathway and stability. These different characteristics make them a good alternative to conventional chromatographic methods and allowing their potential use in separation technology. In the present study, two sets of poly(2-hydroxyethyl methacrylate) (PHEMA) based beads were prepared and functionalized with Reactive Red 120 (RR) and Reactive Green HE 4BD (RG) dyes, and then embedded into supermacroporous cryogels. The morphology, physical and chemical features of the prepared bead embedded composite cryogel discs (CCDs) were performed by scanning electron microscopy (SEM), swelling test, elemental analysis and Fourier transform infrared spectroscopy (FTIR). The results showed that the embedded composite cryogel discs have a specific surface area of 192.0 m{sup 2}/g with maximum adsorption capacity of HIgG 239.8 mg/g for the RR functionalized CCD and 170 mg/g for RG functionalized CCD columns, both at pH 6.2. - Highlights: • Dye attached composite cryogel discs were prepared to separate HIgG subclasses. • Composite cryogels characterized by swelling, FTIR, SEM and elemental analysis. • Reactive Green HE 4B and Reactive Red 120 dyes were used as the affinity ligand. • HIgG and subclasses were separate from both aqueous solution and human plasma.

  14. Causes of the trend in CO{sub 2} emissions in Germany between 1990 to 1995; Ursachen der CO{sub 2}-Entwicklung in Deutschland in den Jahren 1990 bis 1995

    Energy Technology Data Exchange (ETDEWEB)

    Ziesing, H.J. [Deutsches Inst. fuer Wirtschaftsforschung, Berlin (Germany); Jochem, E.; Mannsbart, W.; Schlomann, B.; Bankamp, A.; Frahm, T.; Ulrich, P. [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany)

    1997-11-01

    It is exclusively the new Federal Laender which contributed to the reduction in CO{sub 2} emissions in Germany between 1990 and 1995. As the cross-sector and sector-specific analyses have shown, however, this is attributable not only to the drastic economic downturn which occurred in that region. It should be noted, rather, that contributing factors not only include the lasting changes in fuel structure which were effected in eastern Germany in favour of fuels which are less emission-intensive, but, above all, the reduction in energy intensity in nearly all relevant sectors. This means that energy use in the new Federal Laender has already become considerably more rational in the course of the 1990s to date. Nonetheless, it cannot be overlooked that eastern Germany still lag behind western Germany in this area: For example, in 1995 overall economic energy intensity was nearly 80% greater in the new Federal Laender than in the old Federal Laender, overall economic carbon dioxide intensity was even 140% higher. These figures reveal further major potential for efficiency enhancements - potential which, if made use of, could enable even strong economic growth in the new Federal Laender in the coming years to occur without increasing energy consumption or reversing the trend for CO{sub 2} emissions. (orig.) [Deutsch] Zum Rueckgang der CO{sub 2}-Emissionen in Deutschland in den Jahren von 1990 bis 1995 haben ausschliesslich die neuen Bundeslaender beigetragen. Wie die sektoruebergreifenden und sektorspezifischen Analysen gezeigt haben, ist dies aber nicht lediglich auf den drastischen wirtschaftlichen Einbruch in Ostdeutschland zurueckzufuehren. Vielmehr ist festzustellen, dass dazu nicht nur die nachhaltigen Veraenderungen in der Struktur der in Ostdeutschland eingesetzten Energietraeger zugunsten weniger emissionsintensiver Brennstoffe beigetragen haben, sondern vor allem auch die nahezu alle Sektoren umfassende Reduktion der Energieintensitaet. Dies bedeutet, dass die

  15. Der Einsatz von medizinischen Trainingszentren für die Ausbildung zum Arzt in Deutschland, Österreich und der deutschsprachigen Schweiz [Clinical Skills Labs in Medical Education in Germany, Austria and German Speaking Switzerland

    Directory of Open Access Journals (Sweden)

    Schmidt, Anita

    2008-05-01

    . This would facilitate the development of common quality standards and guidelines for medical skills labs. It also seems to be necessary to define the term “central skills lab” accurately. The authors recommend the Committee on Practical Skills of the Gesellschaft für Medizinische Ausbildung (GMA as a platform for such co-operation. [german] Zielsetzung: Seit der Novellierung der ÄAppO im Jahr 2002 werden im deutschsprachigen Raum an den medizinischen Universitäten zunehmend Medizinische Trainings- und Prüfungszentren eingerichtet. Die vorliegende Erhebung soll einen Überblick über den Stand der Entwicklung in diesem Bereich in Deutschland, Österreich und der deutschsprachigen Schweiz bieten. Methodik: In der Zeit von August bis Dezember 2007 wurden alle 43 medizinischen Fakultäten in Deutschland, Österreich und der deutschsprachigen Schweiz schriftlich befragt. Der Fragebogen umfasste 7 Themenbereiche. Die weitere Auswertung bezieht sich auf Trainingszentren, in denen mehr als eine Disziplin unterrichtet wird („zentrale“ Trainingszentren. Ergebnisse: Der Rücklauf betrug 100%. Von 43 Fakultäten verfügten 33 zum Zeitpunkt der Befragung über ein Trainingszentrum, 24 davon gingen in die weitere Auswertung ein. 22 Trainingszentren waren ärztlich geleitet, die Zahl der Mitarbeiter lag zwischen 1 bis 8, die der studentischen Tutoren zwischen 0 und 40. Das Spektrum der zur Verfügung stehenden Grundfläche reichte von unter 100 Quadratmetern bis zu 2500 Quadratmetern. An den meisten Trainingszentren wurde mit strukturierten Arbeitsanleitungen gearbeitet (19 Einrichtungen, in 18 Einrichtungen unterrichteten Ärzte und studentische Tutoren. In der Mehrheit der Fälle (13 war der Unterricht curricular integriert. An 19 Zentren wurden OSKE durchgeführt. An 19 Zentren wurde mit Simulationspatienten gearbeitet, die in 15 Zentren auch für Prüfungen eingesetzt wurden. 17 Zentren arbeiteten mit problemorientiertem Lernen, 16 setzten computerbasiertes Lernen ein

  16. Scientific measurement and evaluation programme (WMEP). Phase 3. Vol. 1 and 2. Final report; Wissenschaftliches Mess- und Evaluierungsprogramm (WMEP) zum Breitentest ''250 MW Wind''. Phase 3. Bd. 1 und 2. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Doepfer, R.; Durstewitz, M.; Ensslin, C. [and others

    2000-07-01

    The Federal Ministry for Economics and Technology (BMWi) funds the '250 MW Wind' test programme. This programme is designed to acquire statistically relevant data concerning the practical use of wind energy converters (WEC) in the Federal Republic of Germany. The technological and scientific areas of this supportive measure, the so called 'Wissenschaftliches Mess- und Evaluierungsprogramm' (WMEP - Scientific Measurement and Evaluation Programme), are implemented by the Institut fuer Solar Energieversorgungstechnik (ISET - Institute for Solar Energy Supply Technology) in Kassel. The WMEP acquires performance data concerning all funded WECs for a ten year period. The final report on hand describes the results of the 3rd project phase (01/07/96 - 30/06/00) of the WMEP including four annual reports and a summary of the most important fields of work. In this phase, for the first time all evaluations could be based upon the complete plant stock since all funded projects were represented in the programme. As of 30/06/00, a total of 1,497 wind turbines with an installed capacity of 349.5 MW at approx. 1,100 different locations are under supervision. During the whole project phase a maximum of 1,557 turbines was supervised. The rated power of the turbines ranges from 2.5 kW up to 1.5 MW. Evaluations regarding the economy, the estimated lifetime and long-term reliability as well as the power performance of widely dispersed wind turbine systems could be initiated in this project phase. It should also be mentioned, that the WMEP evaluations do now include all wind turbines operated in Germany. (orig.) [German] Das Bundesministerium fuer Wirtschaft und Technologie (BMWi) foerdert mit dem Breitentest '250 MW Wind' die Einfuehrung der Windenergienutzung in Deutschland. Zur Gewinnung statistisch relevanter Erfahrungswerte aus dem praktischen Einsatz von Windenergieanlagen (WEA) wurde das Institut fuer Solare Energieversorgungstechnik e.V. (ISET

  17. Scientific measurement and evaluation programme (WMEP). Phase 3. Vol. 1 and 2. Final report; Wissenschaftliches Mess- und Evaluierungsprogramm (WMEP) zum Breitentest ''250 MW Wind''. Phase 3. Bd. 1 und 2. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Doepfer, R.; Durstewitz, M.; Ensslin, C. [and others

    2000-07-01

    The Federal Ministry for Economics and Technology (BMWi) funds the '250 MW Wind' test programme. This programme is designed to acquire statistically relevant data concerning the practical use of wind energy converters (WEC) in the Federal Republic of Germany. The technological and scientific areas of this supportive measure, the so called 'Wissenschaftliches Mess- und Evaluierungsprogramm' (WMEP - Scientific Measurement and Evaluation Programme), are implemented by the Institut fuer Solar Energieversorgungstechnik (ISET - Institute for Solar Energy Supply Technology) in Kassel. The WMEP acquires performance data concerning all funded WECs for a ten year period. The final report on hand describes the results of the 3rd project phase (01/07/96 - 30/06/00) of the WMEP including four annual reports and a summary of the most important fields of work. In this phase, for the first time all evaluations could be based upon the complete plant stock since all funded projects were represented in the programme. As of 30/06/00, a total of 1,497 wind turbines with an installed capacity of 349.5 MW at approx. 1,100 different locations are under supervision. During the whole project phase a maximum of 1,557 turbines was supervised. The rated power of the turbines ranges from 2.5 kW up to 1.5 MW. Evaluations regarding the economy, the estimated lifetime and long-term reliability as well as the power performance of widely dispersed wind turbine systems could be initiated in this project phase. It should also be mentioned, that the WMEP evaluations do now include all wind turbines operated in Germany. (orig.) [German] Das Bundesministerium fuer Wirtschaft und Technologie (BMWi) foerdert mit dem Breitentest '250 MW Wind' die Einfuehrung der Windenergienutzung in Deutschland. Zur Gewinnung statistisch relevanter Erfahrungswerte aus dem praktischen Einsatz von Windenergieanlagen (WEA) wurde das Institut fuer Solare Energieversorgungstechnik e.V. (ISET

  18. A BD/SINS Integrated Navigation Algorithm and a Clock Error Handling Method%BD/SINS紧组合导航及时钟误差处理算法

    Institute of Scientific and Technical Information of China (English)

    王龙; 王楠; 鲁浩

    2015-01-01

    The navigation accuracy of the pure SINS system can not satisfy the high performance requirement of air-to-air missile when the cruise range of the missile is too long .The GNSS/SINS integrated navigation is an effective method to solve this problem .Because of the successful application of the Beidou satellites navigation system,the research on BD/SINS integrated navigation has become a hot engineering field .In this paper,the integrated navigation algorithm of the BD/SINS is studied .The gain-restriction Kalman filter is adopted in the fusion of the information from the SINS and the BD receiver .In order to mitigate the inverse effect of the clock error of the receiver,a special method is used to eliminate the clock error .Simulation result proved that the integrated navigation method has a high navigation accuracy .%远距空空导弹飞行时间长,纯惯性导航难以满足高精度要求,而卫星定位/捷联惯性组合导航是解决此难题的一种有效方式,因此,采用基于伪距/伪距率的北斗/捷联惯性组合导航算法,该导航算法使用限定增益Kalman滤波器,对接收机钟差做了特殊处理,使得滤波结果不受钟差影响。仿真表明,该北斗/捷联惯性组合导航算法有较高的导航精度。

  19. Multicenter evaluation of the BD max enteric bacterial panel PCR assay for rapid detection of Salmonella spp., Shigella spp., Campylobacter spp. (C. jejuni and C. coli), and Shiga toxin 1 and 2 genes.

    Science.gov (United States)

    Harrington, S M; Buchan, B W; Doern, C; Fader, R; Ferraro, M J; Pillai, D R; Rychert, J; Doyle, L; Lainesse, A; Karchmer, T; Mortensen, J E

    2015-05-01

    Diarrhea due to enteric bacterial pathogens causes significant morbidity and mortality in the United States and worldwide. However, bacterial pathogens may be infrequently identified. Currently, culture and enzyme immunoassays (EIAs) are the primary methods used by clinical laboratories to detect enteric bacterial pathogens. We conducted a multicenter evaluation of the BD Max enteric bacterial panel (EBP) PCR assay in comparison to culture for the detection of Salmonella spp., Shigella spp., Campylobacter jejuni, and Campylobacter coli and an EIA for Shiga toxins 1 and 2. A total of 4,242 preserved or unpreserved stool specimens, including 3,457 specimens collected prospectively and 785 frozen, retrospective samples, were evaluated. Compared to culture or EIA, the positive percent agreement (PPA) and negative percent agreement (NPA) values for the BD Max EBP assay for all specimens combined were as follows: 97.1% and 99.2% for Salmonella spp., 99.1% and 99.7% for Shigella spp., 97.2% and 98.4% for C. jejuni and C. coli, and 97.4% and 99.3% for Shiga toxins, respectively. Discrepant results for prospective samples were resolved with alternate PCR assays and bidirectional sequencing of amplicons. Following discrepant analysis, PPA and NPA values were as follows: 97.3% and 99.8% for Salmonella spp., 99.2% and 100% for Shigella spp., 97.5% and 99.0% for C. jejuni and C. coli, and 100% and 99.7% for Shiga toxins, respectively. No differences in detection were observed for samples preserved in Cary-Blair medium and unpreserved samples. In this large, multicenter study, the BD Max EBP assay showed superior sensitivity compared to conventional methods and excellent specificity for the detection of enteric bacterial pathogens in stool specimens.

  20. Characterization and clinical validation of MCM2 and TOP2A monoclonal antibodies in the BD ProEx™ C assay: An immunoassay which detects aberrant S-phase induction in cervical tissue.

    Science.gov (United States)

    Dixon, Eric P; King, Lorraine M; Nelson, Ramona; Simkins, Stephen G; Knapp, Steven L; Brough, George H; Lenz, Karen L; Henderson, Dorian T; Whitehead, Clark M; Hessling, Janice; Brown, Charlotte A; Malinowski, Douglas P

    2017-03-01

    The Papanicolaou (Pap) screen has been successful in reducing cervical cancer; but exhibits low sensitivity when detecting cervical dysplasia. Use of molecular biomarkers in Pap tests may improve diagnostic accuracy. Monoclonal antibodies to Minichromosome Maintenance Protein 2 (MCM2) and DNA Topoisomerase II α (TOP2A) were selected for use in IHC based on their ability to differentiate normal from diseased cervical tissues in tissue microarrays. Enhanced Green Fluorescent Protein Western blot analysis was used to help identify binding epitopes specific to MCM2 and TOP2A antibody clones. Antibody affinity was determined by solution phase affinity measurement and immunohistochemistry was performed using high affinity MCM2 or TOP2A antibodies on serial histological sections. Antibody clones to MCM2 and TOP2A clones were selected based on their ability to detect over expression in abnormal cervical epithelia. In IHC, MCM2-27C5.6 and MCM2-26H6.19 demonstrated superior staining in abnormal cervical tissue over the MCM2-CRCT2.1 antibody. A combination of MCM2 and TOP2A antibodies showed greater staining when compared to staining with any of the antibodies alone on serial histological sections. Distinct linear epitopes were elucidated for each of the MCM2 and TOP2A clones. Affinity values (Kd) for MCM2 or TOP2A antibodies had a similar range. In a research study, the MCM2 and TOP2A (BD ProEx™ C) antibody cocktail showed increased epithelia staining with increasing dysplasia. The use of BD ProEx™ C in combination with H&E staining enhanced immunohistochemical discrimination of dysplastic and non-dysplastic FFPE cervical tissue specimens. BD ProEx™ C containing MCM2 and TOP2A antibodies showed strong specific nuclear staining that correlated with increased dysplasia and lesion severity. Enhanced performance of the antibodies was linked to their unique topography recognition. BD ProEx™ C incorporates antibodies that enhance detection of CIN2+ cervical disease

  1. Research on BD BACTEC 9120 blood culture instrument combined with serum PCT in diagnosis of bloodstream infections%BD BACTEC 9120血培养仪联合血清降钙素原在血流感染诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    郭盼; 马萍; 王海龙; 董彬; 尚晓泓

    2015-01-01

    目的:比较革兰阳性(G+)菌和革兰阴性(G-)菌血流感染(BSI)的血清降钙素原(PCT)水平,探讨血培养与PCT联合检测在临床诊断中的意义。方法:采用BD BACTEC9120型全自动血培养仪对199例住院发热患者的血液标本进行细菌培养,同时检测PCT水平,比较PCT浓度水平在血培养阳性与阴性之间以及革兰阳性细菌与阴性细菌之间的差异。结果:①筛选出检测PCT的99例血培养阳性标本中分别检出18种细菌,其中表皮葡萄球菌构成比最大(占17.2%);其余依次为大肠埃希菌(占16.2%)和鲍曼不动杆菌(占10.1%);②血培养阳性与血培养阴性标本PCT结果比较差异有统计学意义;③血培养革兰阳性菌与革兰阴性菌PCT结果比较无明显差异,但如果将革兰阳性菌组金黄色葡萄球菌的结果去除,再与革兰阴性菌相比差异有统计学意义。结论:PCT对革兰阴性菌与革兰阳性菌感染有一定的判别作用,配合血培养检测能辅助临床的快速诊断,提示临床初步抗生素的使用方向,减少用药的盲目性和耐药菌株的出现。%Objective: Compare gram-positive (G+)bacteria and gram-negative bacteria (G-) bloodstream infections of serum procalcitonin(PCT) original level, to explore the clinical significance of blood culture and PCT joint detection. Methods: One hundred and ninty nine cases were selected, by using BD BACTEC 9120 type automatic blood culture instrument to detect the bacterial culture and at the same time the PCT results, comparative PCT concentration in blood cultures between positive and negative results and gram-positive bacteria and gram-negative bacteria. Results:(1)Screening detection of PCT were detected in 99 cases of specimens of blood culture positive for 18 species of bacteria including staphylococcus epidermis form than most, by 17.2%;The second is the e. coli were 16.2%and 10.1%acinetobacter baumannii. (2)blood culture positive for

  2. Isolation of RNA from residual BD SurePath liquid-based cytology specimens and detection of HPV E6/E7 mRNA using the PreTectt HPV-Proofer assay.

    Science.gov (United States)

    Dixon, Eric P; King, Lorraine M; Adams, Melissa D; Grønn, Petter; Murphy, Patricia G; Brown, Charlotte A; Brough, George H; Skomedal, Hanne; Malinowski, Douglas P; Fischer, Timothy J

    2008-12-01

    Infection with high-risk human papillomavirus (HPV) is known to be associated directly with the development of cervical cancer. Recent data suggests that the detection of E6/E7 mRNA from high-risk HPV types may serve as a better diagnostic method for detecting the presence of cervical pre-cancer than HPV DNA testing. This report details a commercially available nucleic acid isolation protocol which can be used to isolate reproducibly RNA from residual BD SurePath liquid-based cytology specimens stored for up to 28 days, and have demonstrated the quality and quantity of mRNA is sufficient for detection with the NorChip PreTect HPV-Proofer assay. Of the 242 specimens tested in this study, 236 (97.5%) tested positive for U1A internal control gene expression. HPV type 16, 18, 31, 33 or 45 mRNA was detected in 16/20 (80%) of the analyzed high-grade squamous intraepithelial lesion (HSIL) specimens, with a low frequency of HPV mRNA detected in the normal lesions (3%). The presence of HPV E6 expression in a subset of HPV positive specimens was also detected by real-time RT-PCR. These findings confirm that RNA of sufficient quality can be isolated from residual BD SurePath cervical cytology specimens for use in downstream NASBA and RT-PCR-based assays.

  3. Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion

    Science.gov (United States)

    Lim, Joung Eun; Jeong, Da Eun; Song, Hye Jin; Kim, Sudong; Nam, Do-Hyun; Sung, Hyun Hwan; Jeong, Byong Chang; Seo, Seong Il; Jeon, Seong Soo; Lee, Hyun Moo; Choi, Han-Yong; Jeon, Hwang Gyun

    2016-01-01

    Muscle-invasive bladder cancer (MIBC) consists of a heterogeneous group of tumors with a high rate of metastasis and mortality. To facilitate the in-depth investigation and validation of tailored strategies for MIBC treatment, we have developed an integrated approach using advanced high-throughput drug screening and a clinically relevant patient-derived preclinical platform. We isolated patient-derived tumor cells (PDCs) from a rare MIBC case (BD-138T) that harbors concomitant epidermal growth factor receptor (EGFR) amplification and phosphatase and tensin homolog (PTEN) deletion. High-throughput in vitro drug screening demonstrated that dasatinib, a SRC inhibitor, and PKI-587, a dual PI3K/mTOR inhibitor, exhibited targeted anti-proliferative and pro-apoptotic effects against BD-138T PDCs. Using established patient-derived xenograft models that successfully retain the genomic and molecular characteristics of the parental tumor, we confirmed that these anti-tumor responses occurred through the inhibition of SRC and PI3K/AKT/mTOR signaling pathways. Taken together, these experimental results demonstrate that dasatinib and PKI-587 might serve as promising anticancer drug candidates for treating MIBC with combined EGFR gene amplification and PTEN deletion. PMID:27438149

  4. S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion of E. coli Is Associated with NEC

    Directory of Open Access Journals (Sweden)

    A. C. Jenke

    2013-01-01

    Full Text Available Objective. To describe the development of the gut microbiota in extremely low birth weight (ELBW infants with and without necrotizing enterocolitis (NEC between April 2008 and December 2009, fecal microflora was prospectively analyzed in fecal samples of all ELBW infants using real-time PCR assays. In addition, fecal inflammatory were measured. Results. Fecal microflora established early in ELBW infants and microbiota composition remained stable over the first 28 days of life except for the prevalence of C. difficile which decreased with decreasing antibiotic use. Infants who subsequently developed NEC had an increase of total bacterial count (9.8-fold 24 h prior to clinical symptoms mainly due to the expansion of E. coli species (21.6-fold, whereas microbiota composition did not differ from healthy ELBW infants five days before onset of NEC. Importantly, S100A12 and hBD2 positively correlated with the total and E. coli bacterial CFU/g feces (r2 0.4 and 0.64, resp.. Conclusions. In summary, we found evidence for a disturbed homeostasis between the intestinal microbiome and host immunity in ELBW infants with NEC. Moreover, S100A12 and hBD2 correlate with the fecal microbiota thus linking the intestinal innate immune response to the bacterial colonization thus possibly providing a diagnostic tool in the future.

  5. Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS.

    Science.gov (United States)

    Dahl, Sandra Rinne; Olsen, Kirsten Midtbøen; Strand, Dag Helge

    2012-02-15

    The demand of high throughput methods for the determination of gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butane-diol (1,4BD) as well as for pregabalin is increasing. Here we present two analytical methods using ultra-high pressure liquid chromatography (UPLC) and tandem mass spectrometric (MS/MS) detection for the determination of GHB, beta-hydroxybutyrate (BHB), pregabalin, 1,4BD and GBL in whole blood and urine. Using the 96-well formate, the whole blood method is a simple high-throughput method suitable for screening of large sample amounts. With an easy sample preparation for urine including only dilution and filtration of the sample, the method is suitable for fast screening of urine samples. Both methods showed acceptable linearity, acceptable limits of detection, and limits of quantification. The within-day and between-day precisions of all analytes were lower than 10% RSD. The analytes were extracted from matrices with recoveries near 100%, and no major matrix effects were observed. Both methods have been used as routine screening analyses of whole blood and urine samples since January 2010.

  6. Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae.

    Science.gov (United States)

    Antonelli, Alberto; Arena, Fabio; Giani, Tommaso; Colavecchio, Olga Lorenza; Valeva, Stoyanka Valentinova; Paule, Suzanne; Boleij, Peter; Rossolini, Gian Maria

    2016-09-01

    Carbapenemase-producing Enterobacteriaceae (CPE) represent an increasing public health issue and the early detection of colonization by CPE can help the implementation of infection control measures among inpatients. In this study, BD MAX Check-Direct CPE screen, with two different Master Mixes (BDMix and CPMix), using the automatic BD MAX(™) instrument, was evaluated for the detection of blaKPC, blaOXA-48, blaVIM and blaNDM genes, in comparison to selective broth enrichment and direct culture from rectal swabs. Among a total of 557 rectal swabs samples, 29 (5.2%) tested positive for CPE (23 for blaKPC, 5 for blaVIM and one for blaOXA-48). The sensitivity, specificity, positive and negative likelihood ratios values were 93.1%, 97.3%, 34.5 and 0.07, for BMix, and 100%, 97.1 %, 34.5 and 0 for CPMix, respectively. Five samples were positive with molecular methods only. The turn-around time was reduced from 18-24 hours (direct culture), or 48 h (broth enrichment) to only 3 h.

  7. Cloning and sequence analysis of Wadi sheep defensin sBD-1 gene and establishment and application of SYBR green Ⅰ real-time fluorescence quantitative PCR method%洼地绵羊防御素sBD-1基因克隆、序列分析及SYBR Green Ⅰ实时荧光定量检测方法的建立与应用

    Institute of Scientific and Technical Information of China (English)

    王金良; 郭显坡; 沈志强; 李敏; 任艳玲

    2011-01-01

    根据GenBank上登录的绵羊防御素基因序列,经多重比较后,设计1对引物,从洼地绵羊舌上皮组织中扩增到防御素sBD-1基因,克隆到pMD18-T载体中进行测序.结果表明,扩增基因全长215 bp,编码64个氨基酸.基因进化树分析表明,与蒙古绵羊sBD-1基因有较近的亲缘关系,核苷酸同源性为98.5%;而与黄牛的亲缘关系最远,核苷酸同源性84.6%.氨基酸序列分析表明,序列内无信号肽区域,具有3个潜在的抗原表位.以pMD18-T/sBD-1质粒为模板建立了sBD-1基因SYBR Green Ⅰ荧光定量PCR检测方法,核酸电泳、扩增动力学曲线、溶解曲线及重复性试验表明,检测方法具有良好的稳定性和特异性,得到的回归方程(R2=0.998)表明PCR产物量的对数值与起始模板量之间存在良好的线性关系,从舌、盲肠及输卵管等组织中可以进行有效的检测,检测灵敏度为83.9 copies/μL.该方法为进一步研究防御素sBD-1基因在洼地绵羊抗逆性过程中的作用奠定了基础.%According to the published gene sequences of defensin gene of sheep on GenBank,one pair of primers were designed and defensin Sbd-1 gene was amplified by RT-PCR from tongue epithelial tissue of Wadi sheep. PCR product was cloned into the Pmd18-T vector and sequenced. The results showed that gene amplication of full-length was 215 bp, encoding 64 amino acids. Phylogenetic tree analysis showed that Wadi sheep and Menggu sheep had close phylogenetic relationship,nucleotide homology was 98. 5%;kinship with the Bos taurus as far as the nucleotide ho-mology of 84. 6%. Amino acid sequence analysis showed no signal peptide amino acid sequence in the region, with three potential antigenic epitopes. Sbd-1 gene SYBR Green I fluorescence quantitative PCR method was set up u-sing Pmd18-T/Sbd-l plasmid as a template. Nucleic acid electrophoresis,amplification kinetics,dissolution curve and repeatability tests showed that the methods had good stability and

  8. 艰难梭菌毒素A/B、BD-PCR毒素基因及GDH检测对艰难梭菌相关性腹泻的诊断价值%Detection of Clostridium Botulinum Toxin A/B, BD-PCR Toxin Gene and GDH in the Diagnosis of Clostridium Botulinum Associated Diarrhea

    Institute of Scientific and Technical Information of China (English)

    邵婧; 丁宸; 徐萍萍

    2016-01-01

    目的 探讨艰难梭菌毒素A/B及其相关毒素基因检测对艰难梭菌相关性腹泻的诊断价值.方法 收集2015年1月至2015年10月我院ICU病房腹泻疑似艰难梭菌感染患者的粪便标本133例作为研究对象,分别采用艰难梭菌培养法、CDAB法、PCR毒素基因检测法及艰难梭菌毒素GDH检测法进行检测,以艰难梭菌培养法结果为金标准,计算各方法的诊断指标所包含有的特异度、敏感度、阴性预测值和阳性预测值等.结果 本研究收集的133例粪便标本中,经过金标准粪便样本厌氧培养法检出阳性结果20例,阴性结果113例.CDAB法具有低敏感度(0.550)和高特异度(0.912),诊断符合率为0.932,BD-PCR毒素基因检测法具有高敏感度(0.950)和高特异度(0.929),诊断符合率为0.932,艰难梭菌毒素GDH检测法的高敏感度(0.900)和低特异度(0.779),诊断符合率为0.797.结论 对于疑似艰难梭菌感染,可联合艰难梭菌GDH、艰难梭菌毒素A/B(CDAB)或进行荧光定量PCR毒素基因共同检测,有效降低检测时间,为临床医师及时提供准确的诊断依据,并制定行之有效的治疗措施.

  9. Electric cars for Germany; Deutschland stromert

    Energy Technology Data Exchange (ETDEWEB)

    Wiedemann, Karsten

    2010-09-15

    The German government has defined eight model regions in which electric cars will be funded. Results are not available as yet, but there are experts who criticize the focus on electric-powered vehicles. (orig.)

  10. Wie viel Deutschland steckt im Porsche?

    OpenAIRE

    Ferdinand Dudenhöffer

    2005-01-01

    Prof. Dr. Ferdinand Dudenhöffer, Fachhochschule Gelsenkirchen, beschäftigt sich in seinem Kommentar mit der Frage nach der Höhe des Auslandsanteils an den Fertigungskosten bei einigen deutschen Automobilherstellern. Dabei beschäftigt er sich insbesondere mit dem Porsche Cayenne. Er zeigt, dass der deutsche Fertigungsanteil an diesem Auto bei etwa 33% und nicht bei den von Porsche behaupteten 55% liegt. Beim Porsche Cayenne ist der deutsche Wertschöpfungsanteil wesentlich kleiner als bei ander...

  11. Selten nachgewiesene Spinnenarten aus Deutschland (Arachnida: Araneae

    Directory of Open Access Journals (Sweden)

    Jäger, Peter

    2000-07-01

    Full Text Available Some interesting records collected from 1990 to 1999 are reported. First records of Holocnemus pluchei for Rheinland-Pfalz and Baden-Württemberg and of Uloborus plumipes for Hessen and Schleswig-Holstein are listed. The occurrence of Heteropoda venatoria in Germany is confirmed by recent records in warmhouses in Berlin. Pardosa saturatior is collected from the Bavarian part of the Alps (National Park Berchtesgaden. Information on biology and taxonomy of Pardosa saturatior, Holocnemus pluchei and Heteropoda venatoria are given.

  12. Environmental data 1995; Umweltdaten Deutschland 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The brochure contains concise data on pollution sources and pollutant effects on the environment (land use, airborne pollutants, liquid effluents, waste, noise, etc.), data on environment quality (air pollution levels, water quality, diversity of species, etc.), and data on the social effects of environmental pollution (environmental protection expenditures, market shares of low-polluting passenger cars and unleaded fuel, biological sewage treatment systems, etc.). All these data are suitable indicators for describing the current environmental situation. (orig./KW) [Deutsch] Die Broschuero umfasst in komprimierter Weise - Daten zu den Verursachern von Umweltbelastungen und zu den Einwirkungen auf die Umwelt (Bodennutzung, Luftemissionen, Abwasser, Abfaelle, Laerm etc.), - Daten zur Qualitaet der Umwelt (Immissionen, Gewaesserguete, Artenvielfalt etc.) sowie - Daten zur gesellschaftlichen Reaktion auf die Umweltbelastung (Ausgaben fuer den Umweltschutz, Anteil schadstoffarmer Pkw und bleifreien Benzins, Anschluss der Bevoelkerung an biologische Klaeranlagen etc.), die als Indikatoren zur Beschreibung der Umweltsituation geeignet erscheinen. (orig./KW)

  13. Untersuchungen zur Situation der Pferdereproduktionsmedizin in Deutschland

    OpenAIRE

    Stolz, Viola

    2008-01-01

    Ziel der Untersuchungen war es, Informationen über Pferdereproduktion durch Befragung von Pferdezüchtern und Tierärzten zu erhalten. Dies ist notwendig, um die Konzepte und Inhalte der Jahre mit der Situation in der Praxis abzugleichen, um aktuelle Fragestellungen bearbeiten zu können und die Ausbildung auf die Anforderungen im Beruf auszurichten. Folgende relevante Ergebnisse wurden erzielt: Befragung der Züchter 1. Insgesamt wurden 205 Züchter aus neun Bundesländern, die zusa...

  14. Boom in Germany; Boom in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, Bernward

    2013-02-15

    In the year 2012, the expansion of the wind energy in Germany has newly gained a rise: 1,008 wind power plants with a total performance of 2,439 megawatt. The average performance of new wind turbines increases further. The average rotor diameter amounts 88.5 metres, while the average hub height amounts 109.8 metres. Above all, the southern Federal States of the Federal Republic of Germany jeopardise on large hub heights: With a hub height of 133.9 metres, Bavaria is in the vanguard of all Federal States followed by Baden-Wuerttemberg with a hub height of 129.9 metres. The wind power plants in Schleswig-Holstein have the lowest average hub height of 81.7 metres. Meanwhile, the repowering occurs in Schleswig-Holstein and Niedersachsen because there are the oldest wind power plants.

  15. Entstehung und Entwicklung der Spendersamenbehandlung in Deutschland

    Directory of Open Access Journals (Sweden)

    Katzorke Th

    2008-01-01

    Full Text Available Seit der ersten dokumentierten instrumentellen Spendersamenübertragung (Philadelphia 1884 bei männlicher Zeugungsunfähigkeit ist diese Behandlungsmethode Gegenstand äußerst kontrovers geführter Diskussionen: ethische, moralische, juristische, religiöse und viele andere Bereiche werden tangiert. Trotzdem wird die Samenspende heute als eine allgemein akzeptierte, wissenschaftlich begründete und zulässige Therapieform in sämtlichen Industrieländern betrachtet. Es gibt bisher keinen Anhalt für eine Einschränkung der Lebensqualität der späteren Eltern und der so gezeugten Kinder. Lediglich die Praxis der Anonymisierung ist ungeklärt. Konkretisiert werden muss z. B. besonders das deutsche Recht im Hinblick auf das Erbrecht. Weiterhin müssten im Zuge der Revision des bestehenden Embryonenschutzgesetzes oder durch Erlass eines neuen Fortpflanzungsmedizingesetzes den veränderten gesellschaftlichen Entwicklungen Rechnung getragen werden. Hier muss von der Gesellschaft besonders zu der Frage der Behandlung von ledigen Frauen und gleichgeschlechtlichen Paaren Stellung genommen werden.

  16. Zustand und Perspektiven der Kapitalmarktfinanzierung in Deutschland

    DEFF Research Database (Denmark)

    Beck, Thorsten; Kaserer, Christoph; Rapp, Marc Steffen

    2016-01-01

    Die Autoren haben sich im Rahmen des durch das Bundesministerium für Wirtschaft und Energie (BMWi) in Auftrag gegebenen Forschungsprojekts „Beteiligungs- und Kapitalmarktfinanzierung im deutschen Finanzsystem: Zustand und Entwicklungsperspektiven“ (Dienstleistungsprojekt I C 4 -27/14) mit dem Zus...

  17. Latrodectus mactans nach Deutschland eingeschleppt (Araneae: Theridiidae)

    OpenAIRE

    Jäger, Peter

    2010-01-01

    Latrodectus mactans (Fabricius, 1775) was recorded from Germany. The species was most likely introduced with cargo from Chicago, USA. Characters of the single female are illustrated for future identification.

  18. Latrodectus mactans nach Deutschland eingeschleppt (Araneae: Theridiidae

    Directory of Open Access Journals (Sweden)

    Jäger, Peter

    2009-07-01

    Full Text Available Latrodectus mactans (Fabricius, 1775 was recorded from Germany. The species was most likely introduced with cargo from Chicago, USA. Characters of the single female are illustrated for future identification.

  19. Latrodectus mactans nach Deutschland eingeschleppt (Araneae: Theridiidae)

    OpenAIRE

    Jäger, Peter

    2009-01-01

    Latrodectus mactans (Fabricius, 1775) was recorded from Germany. The species was most likely introduced with cargo from Chicago, USA. Characters of the single female are illustrated for future identification.

  20. Das Buch über Deutschland

    DEFF Research Database (Denmark)

    Fleischer, Holm

    Bogen giver et indblik i det tyske samfund i begyndelsen af det 21. århunderede. Der bliver gennemgået følgende emner: statsopbygning, sociale forhold, økonomi, uddannelsessystem, forskelle mellem Øst- og Vesttyskland, Immigration, kultur....

  1. Salafismus in Deutschland: eine Gefahrenperspektive neu bewertet

    OpenAIRE

    Hummel, Klaus

    2014-01-01

    "Just a few years ago, Salafism was a phenomenon completely unknown in Germany. Today it is 'the' paradigm of security research, most of all when it comes to jihad in Germany. The essay points out why a differentiated concept of 'Salafism' may make an analytically fruitful contribution to our understanding of this complex phenomenon of violence. However, also part of the prospect of danger is the fact that overstraining the concept is rather part of that problem which must be prioritised and ...

  2. Benchmarking Compound Methods (CBS-QB3, CBS-APNO, G3, G4, W1BD) against the Active Thermochemical Tables: A Litmus Test for Cost-Effective Molecular Formation Enthalpies.

    Science.gov (United States)

    Simmie, John M; Somers, Kieran P

    2015-07-16

    The theoretical atomization energies of some 45 CxHyOz molecules present in the Active Thermochemical Tables compilation and of particular interest to the combustion chemistry community have been computed using five composite model chemistries as titled. The species contain between 1-8 "heavy" atoms, and a few are conformationally diverse with up to nine conformers. The enthalpies of formation at 0 and 298.15 K are then derived via the atomization method and compared against the recommended values. In general, there is very good agreement between our averaged computed values and those in the ATcT; those for 1,3-cyclopentadiene exceptionally differ considerably, and we show from isodesmic reactions that the true value for 1,3-cyclopentadiene is closer to 134 kJ mol(-1) than the reported 101 kJ mol(-1). If one is restricted to using a single method, statistical measures indicate that the best methods are in the rank order G3 ≈ G4 > W1BD > CBS-APNO > CBS-QB3. The CBS-x methods do on average predict ΔfH(⊖)(298.15 K) within ≈5 kJ mol(-1) but are prone to occasional lapses. There are statistical advantages to be gained from using a number of methods in tandem, and all possible combinations have been tested. We find that the average formation enthalpy coming from using CBS-APNO/G4, CBS-APNO/G3, and G3/G4 show lower mean signed and mean unsigned errors, and lower standard and root-mean-squared deviations, than any of these methods in isolation. Combining these methods also leads to the added benefit of providing an uncertainty rooted in the chemical species under investigation. In general, CBS-APNO and W1BD tend to underestimate the formation enthalpies of target species, whereas CBS-QB3, G3, and G4 have a tendency to overestimate the same. Thus, combining CBS-APNO with a G3/G4 combination leads to an improvement in all statistical measures of accuracy and precision, predicting the ATcT values to within 0.14 ± 4.21 kJ mol(-1), thus rivalling "chemical accuracy" (

  3. Die Zukunft der ärztlichen Weiterbildung in Deutschland – Positionspapier des Ausschusses Weiterbildung der Gesellschaft für Medizinische Ausbildung (GMA [The future of graduate medical education in Germany – Position paper of the committee on graduate medical education of the Society for Medical Education (GMA

    Directory of Open Access Journals (Sweden)

    Weih, Markus

    2013-05-01

    Full Text Available [english] The German graduate medical education system is going through an important phase of changes. Besides the ongoing reform of the national guidelines for graduate medical education (Musterweiterbildungsordnung, other factors like societal and demographic changes, health and research policy reforms also play a central role for the future and competitiveness of graduate medical education.With this position paper, the committee on graduate medical education of the Society for Medical Education (GMA would like to point out some central questions for this process and support the current discourse.As an interprofessional and interdisciplinary scientific society, the GMA has the resources to contribute in a meaningful way to an evidence-based and future-oriented graduate medical education strategy.In this position paper, we use four key questions with regards to educational goals, quality assurance, teaching competence and policy requirements to address the core issues for the future of graduate medical education in Germany. The GMA sees its task in contributing to the necessary reform processes as the only German speaking scientific society in the field of medical education.[german] Die ärztliche Weiterbildung in Deutschland befindet sich im Umbruch. Neben der aktuellen Reform der Musterweiterbildungsordnung spielen gesellschaftliche, demographische, gesundheits- und forschungspolitische Faktoren eine wichtige Rolle für die Zukunft und Konkurrenzfähigkeit der ärztlichen Weiterbildung.Der Ausschuss für Weiterbildung der Gesellschaft für Medizinische Ausbildung (GMA möchte mit diesem Positionspapier auf zentrale Fragen in diesem Prozess aufmerksam machen und Impulse für den aktuellen Diskurs geben.Dabei kann die GMA als interdisziplinäre und interprofessionelle Fachgesellschaft wichtige Beiträge zu einer evidenzbasierten und zukunftsorientierten Weiterbildungsstrategie liefern.Im vorliegenden Papier werden anhand von vier Leitfragen zu

  4. The discovery of a new infrared emission feature at 1905 wavenumbers (5.25 microns) in the spectrum of BD + 30 deg 3639 and its relation to the polycyclic aromatic hydrocarbon model

    Science.gov (United States)

    Allamandola, L. J.; Bregman, J. D.; Sandford, S. A.; Tielens, A. G. G. M.; Witteborn, F. C.

    1989-01-01

    A new IR emission feature at 1905/cm (5.25 microns) has been discovered in the spectrum of BD + 30 deg 3639. This feature joins the family of well-known IR emission features at 3040, 2940, 1750, 1610, '1310', 1160, and 890/cm. The origin of this new feature is discussed and it is assigned to an overtone or combination band involving C-H bending modes of polycyclic aromatic hydrocarbons (PAHs). Laboratory work suggests that spectral studies of the 2000-1650/cm region may be very useful in elucidating the molecular structure of interstellar PAHs. The new feature, in conjunction with other recently discovered spectral structures, suggests that the narrow IR emission features originate in PAH molecules rather than large carbon grains.

  5. LOOKING FOR A CONNECTION BETWEEN THE Am PHENOMENON AND HYBRID {delta} Sct -{gamma} Dor PULSATION: DETERMINATION OF THE FUNDAMENTAL PARAMETERS AND ABUNDANCES OF HD 114839 AND BD +18 4914

    Energy Technology Data Exchange (ETDEWEB)

    Hareter, M.; Weiss, W. [Department of Astronomy, University of Vienna, Tuerkenschanzstrasse 17, A-1180 Wien (Austria); Fossati, L. [Department of Physics and Astronomy, Open University, Walton Hall, Milton Keynes MK6 7AA (United Kingdom); Suarez, J. C. [Instituto de Astrofisica de Andalucia (CSIC), Glorieta de la Astronomia S/N, 18008, Granada (Spain); Uytterhoeven, K. [Kiepenheuer-Institut fuer Sonnenphysik, Schoeneckstr. 6, D-79104 Freiburg (Germany); Rainer, M.; Poretti, E., E-mail: hareter@astro.univie.ac.at [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, 23807, Merate (Saint Lucia) (Italy)

    2011-12-20

    {delta} Sct-{gamma} Dor hybrids pulsate simultaneously in p- and g-modes, which carry information on the structure of the envelope as well as to the core. Hence, they are key objects for investigating A and F type stars with asteroseismic techniques. An important requirement for seismic modeling is small errors in temperature, gravity, and chemical composition. Furthermore, we want to investigate the existence of an abundance indicator typical for hybrids, something that is well established for the roAp stars. Previous to the present investigation, the abundance pattern of only one hybrid and another hybrid candidate has been published. We obtained high-resolution spectra of HD 114839 and BD +18 4914 using the SOPHIE spectrograph of the Observatoire de Haute-Provence and the HARPS spectrograph at ESO La Silla. For each star we determined fundamental parameters and photospheric abundances of 16 chemical elements by comparing synthetic spectra with the observations. We compare our results to that of seven {delta} Sct and nine {gamma} Dor stars. For the evolved BD +18 4914 we found an abundance pattern typical for an Am star, but could not confirm this peculiarity for the less evolved star HD 114839, which is classified in the literature as uncertain Am star. Our result supports the concept of evolved Am stars being unstable. With our investigation we nearly doubled the number of spectroscopically analyzed {delta} Sct-{gamma} Dor hybrid stars, but did not yet succeed in identifying a spectroscopic signature for this group of pulsating stars. A statistically significant spectroscopic investigation of {delta} Sct- {gamma} Dor hybrid stars is still missing, but would be rewarding considering the asteroseismological potential of this group.

  6. Particle reduction strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. PM10- and PM2.5-reduction potentials by package of measures for further immission reduction in Germany. Sub-report.; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. PM10- und PM2,5-Minderungspotenziale von Massnahmenpaketen zur weiteren Reduzierung der Immissionen in Deutschland. Teilbericht

    Energy Technology Data Exchange (ETDEWEB)

    Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

    2013-06-15

    This report documents the effects of additional emission control measures the PM10 and PM2.5 air quality in Germany (PM = particulate matter). The immission effects of the planned measures were calculated with the Chemistry-Aerosol-Transport Model REM CALGRID (RCG). [German] Dieser Bericht dokumentiert die Auswirkungen zusaetzlicher emissionsmindernder Massnahmen auf die PM10 und PM2.5-Luftqualitaet in Deutschland. Die immissionsseitigen Auswirkungen der geplanten Massnahmen wurden auf der Basis von Berechnungen mit dem Chemie-Aerosol-Transportmodell REM-CALGRID (RCG) bestimmt. Grundlage der Szenarienrechnungen sind die im Rahmen des F and E-Vorhabens entwickelten Emissionsabschaetzungen, die die Aenderung der Emissionen aufgrund von technischen oder nicht-technischen Massnahmen beschreiben. Die den Berechnungen zugrunde liegende horizontale Aufloesung betraegt 0.125 Laenge und 0.0625 Breite oder circa 7 km x 8 km. Das meteorologische Referenzjahr ist 2005.

  7. Particle Reduction Strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. NO{sub 2}- and O{sub 3} reduction potentials of package of measures for further reduction of immissions in Germany; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. NO{sub 2}- und O{sub 3}-Minderungspotenziale von Massnahmenpaketen zur weiteren Reduzierung der Immissionen in Deutschland. Teilbericht

    Energy Technology Data Exchange (ETDEWEB)

    Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

    2013-06-15

    This report documents the effects of additional emission control measures the NO{sub 2}- and ozone-air quality in Germany (PM = particulate matter). The immission effects of the planned measures were calculated with the Chemistry-Aerosol-Transport Model REM CALGRID (RCG). [German] Dieser Bericht dokumentiert die Auswirkungen zusaetzlicher emissionsmindernder Massnahmen auf die NO{sub 2}- und die Ozon-Luftqualitaet in Deutschland. Die immissionsseitigen Auswirkungen der geplanten Massnahmen wurden auf der Basis von Berechnungen mit dem Chemie- Aerosol-Transportmodell REM-CALGRID (RCG) bestimmt. Grundlage der Szenarienrechnungen sind die im Rahmen des F and E-Vorhabens entwickelten Emissionsabschaetzungen, die die Aenderung der Emissionen aufgrund von technischen oder nicht-technischen Massnahmen beschreiben. Die den Berechnungen zugrunde liegende horizontale Aufloesung betraegt 0.125 Laenge und 0.0625 Breite oder circa 7 km x 8 km. Das meteorologische Referenzjahr ist 2005.

  8. Fourth report by the Federal German Government to the Bundestag on measures for the protection of the ozone layer; 4. Bericht der Bundesregierung an den Deutschen Bundestag ueber Massnahmen zum Schutz der Ozonschicht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This report, which relates the situation as of July 1997, again confirms the internationally leading role of the Federal German Republic in the phase-out of CFCs. No country has realised a more comprehensive concept for the phase-out of substances that deplete the ozone layer. Combining statutory and voluntary measures has proved a path-breaking approach. One of the most important driving forces in the CFC phase-out were the restrictions of use imposed by the Ordinance on the Prohibition of CFCs and Halon. (orig./SR) [Deutsch] Dieser Bericht - mit Stand vom Juli 1997 - bestaetigt erneut die internationale Fuehrungsrolle der Bundesrepublik Deutschland beim FCKW-Ausstieg. In keinem anderen Staaat wurde ein umfassenderes Konzept zum Ausstieg aus den ozonabbauenden Stoffen realisiert. Als wegweisend hat sich dabei die Verknuepfung ordnungsrechtlicher und freiwilliger Massnahem erwiesen. Insbesondere von den Verwendungsbeschraenkungen der FCKW-Halon-Verbots-Verordnung gingen wichtige Impulse beim FCKW-Ausstieg aus. (orig./SR)

  9. Verein Deutscher Kohlenimporteure. Annual report 2000; Verein Deutscher Kohlenimporteure. Jahresbericht 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-25

    Energy economy developments of the world, the EU and West Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. (HS) [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt. (HS)

  10. Verein Deutscher Kohlenimporteure. Annual report 1997; Verein Deutscher Kohlenimporteure. Jahresbericht 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    Energy economy developments of the word, the EU and West Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. (HS) [Deutsch] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt. (HS)

  11. The natural gas industry - a survey; Erdgaswirtschaft - Eine Branche im Ueberblick

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [German] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

  12. Disaster medicine. A guide for medical care in case of disasters; 4. rev. ed.; Katastrophenmedizin. Leitfaden fuer die aerztliche Versorgung im Katastrophenfall

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This is the fourth edition of a vademecum for medical experts in the Federal Republic of Germany, published by the Civil Defence Commission, an advisory body of the Federal Ministry of the Interior. The booklet is to help to provide and organize medical care in case of disasters, panic, mass injuries, radiation damage, poisoning and epidemics. There is a separate chapter on radiation accidents and radiation disasters as well as an appendix with a glossary of radiological terms and a list of radiation protection centers. (orig/MG) [Deutsch] Die Schutzkommission, ein Beratergremium beim Bundesminister des Innern, legt hiermit ein Vademecum fuer die Aerzte in der Bundesrepublik Deutschland in vierter Auflage vor. Es soll in Katastrophenfaellen helfen, beim Auftreten von Panik, Massenverletzungen, Strahlenschaeden, Vergiftungen und Seuchen das aerztlich Notwendige zu tun oder zu veranlassen. In einem Kapitel werden darin ausfuehrlich die aerztlichen Massnahmen bei Strahlenunfaellen und Strahlenkatastrophen beschrieben. Im Anhang findet sich ein radiologisches Glossar sowie eine Auflistung regionaler Strahlenschutzzentren. (orig./MG).

  13. Grundlagen der Nieren- und Leberdialyse

    Science.gov (United States)

    Schreiber, Christian; Al-Chalabi, Ahmed N. Ar.; Tanase, Oana; Kreymann, Bernhard

    Die Dialyse ist ein künstliches Blutreinigungsverfahren, das sowohl mit der Nachahmung physiologischer Vorgänge als auch mit der Benutzung bestimmter physikalisch- chemischer Gesetze arbeitet. Ihre technische Umsetzung in einer Dialysemaschine sowie chirurgische und internistische Interventionen gehören zu dem Zusammenspiel unterschiedlicher Disziplinen, die eine Dialyse ermöglichen. Die Grundlagen des Dialyseverfahrens, die Maschine und die Unterschiede von Nieren- und Leberdialyse sollen im Folgenden erklärt werden. Heute besteht in der Bundesrepublik Deutschland bei ca. 55.000 Patienten ein chronisch dialysepflichtiges Nierenversagen (Stand 2005). Das Leben dieser Patienten kann mit der Dialyse um Jahrzehnte verlängert werden. Damit ist die Nierendialyse eines der erfolgreichsten medizintechnischen Verfahren. Bei der Leberdialyse sind ebenbürtige Erfolge noch nicht erzielt worden. Umso wichtiger ist es, hier neue Wege zu finden, um auch für Leberpatienten ein effizientes Dialyseverfahren zu etablieren.

  14. Fundamentals of the natural gas industry. November 1997; Grundzuege der Erdgaswirtschaft. November 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [Deutsch] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

  15. Fundamentals of the natural gas industry. May 1997; Grundzuege der Erdgaswirtschaft. Mai 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    The situation of natural gas in the Federal Republic of Germany is described, with particular emphasis on the advantages and consequences of natural gas supply. The brochure discusses the role of natural gas on the energy market, the reliability of natural gas supply, the environmental impacts, the energy-saving effect of natural gas, natural gas prices, the competitive strength of the German gas industry, and the long-term reliability of natural gas supply. (orig.) [Deutsch] Die Situation des Erdgases in der Bundesrepublik Deutschland wird beschrieben, wobei die wichtigsten Vorteile und Auswirkungen der Erdgasversorgung besonders hervorgehoben werden. Es geht um die Stellung des Erdgases im Energiemarkt, die Sicherheit der Energieversorgung, Umweltschutz, Energieeinsparung durch Erdgaseinsatz, Erdgaspreise, Leistungsfaehigkeit der deutschen Gaswirtschaft und um die langfristig gesicherte Erdgasversorgung. (orig.)

  16. Verein der Kohlenimporteure. Annual report 2002; Verein der Kohlenimporteure. Jahresbericht 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Energy economy developments of the world, the European Union and the Federal Republic of Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der Europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt.

  17. Verein Deutscher Kohlenimporteure. Annual report 2001; Verein Deutscher Kohlenimporteure. Jahresbericht 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Energy economy developments of the world, the EU and West Germany are gone into. The main aspects discussed are the coal market and trade which depends on political decisions and concepts, but also on the availability of other primary energy sources such as oil and nuclear power. The situation of the various countries in the field of coal is illustrated by so-called country reports. [German] Es wird auf die energiewirtschaftliche Entwicklung sowohl der Welt als auch der europaeischen Union und speziell der Bundesrepublik Deutschland eingegangen. Im Vordergrund steht dabei der Kohlenmarkt und -handel, der von politischen Erscheinungen und Konzepten abhaengig ist, aber auch von der Entwicklung anderer Primaerenergien wie Oel und Kernkraft. In den sogenannten Laenderberichten wird die kohlewirtschaftliche Diskussion einzelner Laender behandelt.

  18. The discovery of a new infrared emission feature at 1905 wavenumbers (5.25 microns) in the spectrum of BD +30 degrees 3639 and its relation to the polycyclic aromatic hydrocarbon model

    Science.gov (United States)

    Allamandola, L. J.; Bregman, J. D.; Sandford, S. A.; Tielens, A. G.; Witteborn, F. C.; Wooden, D. H.; Rank, D.

    1989-01-01

    We have discovered a new IR emission feature at 1905 cm-1 (5.25 microns) in the spectrum of BD +30 degrees 3639. This feature joins the family of well-known IR emission features at 3040, 2940, 1750, 1610, "1310," 1160, and 890 cm-1 (3.3, 3.4, 5.7, 6.2, "7.7," 8.6, and 11.2 microns). The origin of this new feature is discussed and it is assigned to an overtone or combination band involving C-H bending modes of polycyclic aromatic hydrocarbons (PAHs). Laboratory work suggests that spectral studies of the 2000-1650 cm-1 (5.0-6.1 microns) region may be very useful in elucidating the molecular structure of interstellar PAHs. The new feature, in conjunction with other recently discovered spectral structure, suggests that the narrow IR emission features originate in PAH molecules rather than large carbon grains. Larger species are likely to be the source of the broad underlying "plateaus" seen in many of the spectra.

  19. Multicenter evaluation of the Sepsityper™ extraction kit and MALDI-TOF MS for direct identification of positive blood culture isolates using the BD BACTEC™ FX and VersaTREK(®) diagnostic blood culture systems.

    Science.gov (United States)

    Schieffer, K M; Tan, K E; Stamper, P D; Somogyi, A; Andrea, S B; Wakefield, T; Romagnoli, M; Chapin, K C; Wolk, D M; Carroll, K C

    2014-04-01

    (i) Evaluation of delayed time to blood culture extraction by the Sepsityper kit and impact of shipping pellets off-site for MALDI-TOF MS analysis. (ii) Comparison of Sepsityper and laboratory-developed extraction methods from a literature review. Using two blood culture systems (BD BACTEC and VersaTREK), we extracted 411 positive blood cultures using the Sepsityper kit to mimic a potential protocol for institutions without a MALDI-TOF MS. Extracted pellets were shipped and analysed on the Bruker UltraflexIII. Successful extraction of 358 (87·1%) samples was determined by the presence of detectable proteins. MALDI-TOF MS correctly identified 332 (80·8%) samples. Delayed time to extraction did not affect Sepsityper extraction or MALDI-TOF MS accuracy. The extracted pellets remain stable and provide accurate results by MALDI-TOF MS when shipped at room temperature to off-site reference laboratories. This is the first study to show that institutions without a MALDI-TOF MS can take advantage of this innovative technology by shipping a volume of blood to an off-site laboratory for extraction and MALDI-TOF MS analysis. We also performed a literature review to compare various extraction methods. © 2014 The Society for Applied Microbiology.

  20. Plutarque, Sur l' E de Delphes 390 B 6-8 et l'explication de  la vision en Timée 45 b-d*

    Directory of Open Access Journals (Sweden)

    Alain Lernould

    2005-04-01

    Full Text Available Le traité (ou dialogue « pythique » du platonicien Plutarque de Chéronée (Iier – IIe s. ap. J.-C. intitulé Sur l’E de Delphes est consacré à l’élucidation de la signification de l’E (la cinquième lettre de l’alphabet grec consacré à Apollon Pythien. Une des interprétations (d’inspiration pythagoricienne est que cet E désigne le nombre cinq, le nombre de l’univers. Dans le cadre de l’exposé de cette interprétation est fait état de l’opinion « de certains » selon laquelle il existe une correspondance entre les cinq sens et les cinq éléments. L’A. montre que les deux lignes où il est question de la vue (E 390b6-8 s’inspirent essentiellement de l’explication qu’en Timée 45b-d Platon donne du mécanisme de la vision en termes de mélange du feu pur émis par l’œil avec le feu pur extérieur qui produit la lumière du jour. L’extrême brièveté de ce résumé (empreint d’aristotélisme, l’élément associé à la vue étant ici l’éther considéré comme cinquième corps, d’un passage dans Platon offrant lui-même bon nombre de difficultés, explique que ces deux lignes énigmatiques n’aient jamais été bien comprises. Au passage, l’A. revient sur les notions d’homoiopatheia (d’homogénéité et de summetria (de commensurabilité en Timée 45b-d et 67c-e pour en proposer une interprétation qui souligne et éclaire d’un jour nouveau le caractère dynamique de l’explication platonicienne de la vision. Un Appendice donne un aperçu des différentes lectures d’E 390b6-8 depuis les premières éditions imprimées à la Renaissance jusqu’aux éditions critiques des 19e et 20e siècles.The essay (or dialogue On the E at Delphi of the Platonist Plutarch of Chaeronea (c. 50 – c. 125 A.D. is devoted to the elucidation of the mysterious E – the fifth letter of the Greek alphabet – that is dedicated to Apollo. According to one interpretation the E is, in a Pythagorean

  1. Brief introduction of the systematic treatment enhancement program for bipolar disorder%双相障碍系统治疗的增强计划(STEP-BD)简介

    Institute of Scientific and Technical Information of China (English)

    叶尘宇

    2009-01-01

    @@ 双相障碍系统治疗的增强计划(systematic treatment enhancement program for bipolar disorder,STEP-BD)是由美国国立精神卫生研究所出资进行的研究(REP98-DS-0001),以探讨治疗双相障碍有效的共同的干预模式.该研究从1999年正式启动,历时6年之久,由哈佛医学院、马萨诸塞洲医院的Sachs教授总负责.目前根据所收集的资料已发表了70余篇相关的研究文献,并且仍有资料在分析中.在此,本文对于STEP-BP的研究背景、研究目的、研究设计和主要研究结果作一简述.

  2. Direct inoculation method using BacT/ALERT 3D and BD Phoenix System allows rapid and accurate identification and susceptibility testing for both Gram-positive cocci and Gram-negative rods in aerobic blood cultures.

    Science.gov (United States)

    Yonetani, Shota; Okazaki, Mitsuhiro; Araki, Koji; Makino, Hiroshi; Fukugawa, Yoko; Okuyama, Takahiro; Ohnishi, Hiroaki; Watanabe, Takashi

    2012-06-01

    This study describes a direct inoculation method using the automated BacT/ALERT 3D and the BD Phoenix System in combination for identification and susceptibility testing of isolates from positive blood cultures. Organism identification and susceptibility results were compared with the conventional method for 211 positive aerobic blood cultures. Of 110 Gram-positive cocci (GPCs), 98 (89.1%) isolates were correctly identified to the species level. Of 101 Gram-negative rods (GNRs), 98 (97.0%) isolates were correctly identified to the species level. The overall categorical agreement in antimicrobial susceptibility testing among the 110 GPCs was 92.7%, with 0.04% very major and 0.7% major error rates. The overall categorical agreement among 78 isolates of enterobacteria and 23 isolates of nonfermenters in GNRs was 99.5% and 91.1%, respectively, with no major errors identified. We conclude that, compared with previously reported direct inoculation methods, our method is superior in identification and susceptibility testing of GPCs.

  3. Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use.

    Science.gov (United States)

    Corkery, John M; Loi, Barbara; Claridge, Hugh; Goodair, Christine; Corazza, Ornella; Elliott, Simon; Schifano, Fabrizio

    2015-06-01

    Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths. This paper reviews knowledge on GHB and derivatives, and explores the largest series of deaths associated with their non-medical use. Descriptive analyses of cases associated with GHB/GBL and 1,4-butanediol (1,4-BD) use extracted from the UK's National Programme on Substance Abuse Deaths database. From 1995 to September 2013, 159 GHB/GBL-associated fatalities were reported. Typical victims: White (92%); young (mean age 32 years); male (82%); with a drug misuse history (70%). Most deaths (79%) were accidental or related to drug use, the remainder (potential) suicides. GHB/GBL alone was implicated in 37%; alcohol 14%; other drugs 28%; other drugs and alcohol 15%. Its endogenous nature and rapid elimination limit toxicological detection. Post-mortem blood levels: mean 482 (range 0-6500; SD 758)mg/L. Results suggest significant caution is needed when ingesting GHB/GBL, particularly with alcohol, benzodiazepines, opiates, stimulants, and ketamine. More awareness is needed about risks associated with consumption.

  4. Simultaneous determination of γ-Hydroxybutyrate (GHB) and its analogues (GBL, 1.4-BD, GVL) in whole blood and urine by liquid chromatography coupled to tandem mass spectrometry.

    Science.gov (United States)

    Johansen, Sys Stybe; Windberg, Charlotte Norup

    2011-01-01

    A simple liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for simultaneous identification and quantification of γ-hydroxybutyrate (GHB), γ-butyrolactone (GBL), 1.4-butanediol (1.4-BD), and γ-valerolactone (GVL) in whole blood from forensic cases. The sample preparation of whole blood involved protein precipitation by acidic methanol. Urine samples were diluted and evaluated in relation to a control at the cutoff concentration. Hexadeutero GHB (GHB-d(6)) was used as the internal standard. Separation was achieved by reversed-phase chromatography, and detection was by MS-MS in MRM mode. The linear range for all compounds was from 1.0 to 100 mg/kg in whole blood with a limit of quantification of about 1 mg/kg. The method was validated with regards to selectivity, recovery, accuracy and precision, and stability. The method is currently applied to investigations on suspected drug-facilitated sexual assaults, driving under the influence of drugs, and general intoxication with these substances.

  5. Development of CO{sub 2} emissions in Germany in 2016. However, an approach to the target for 2020 again fails to appear; Entwicklung der CO{sub 2}-Emissionen in Deutschland im Jahr 2016. Annaeherung an das Ziel fuer 2020 bleibt abermals aus

    Energy Technology Data Exchange (ETDEWEB)

    Ziesing, Hans-Joachim

    2017-06-15

    In 2016, the total CO{sub 2} emissions in Germany again rose slightly. Compared to the previous year, they were about 0.5% (4.2 million tonnes) higher than in the previous year. Temperature-adjusted, however, the emissions remained practical unchanged. Emissions of all greenhouse gases are likely to have risen by around 0.4% (just under 4 million tonnes) in 2016 or have remained almost constant at the previous year's level. Independent of the assessment of the changes in the values of origin or the temperature-adjusted values, the 2016 target route was clearly missed. To this end, the unadjusted greenhouse gas emissions would have to fall by around 3,6% or around 30 million tonnes in 2016. In order to achieve the 40% reduction target by 2020, emissions must be reduced by almost 39 million t CO{sub 2} equivalents every year over the four years from 2017 to 2020. Significant climate protection policy needs are evident. [German] Im Jahr 2016 sind die gesamten CO{sub 2}-Emissionen in Deutschland erneut leicht gestiegen. Gegenueber dem Vorjahr waren sie um etwa 0,5 % (4,2 Mio. t) hoeher als im Vorjahr. Temperaturbereinigt blieben die Emissionen allerdings praktisch unveraendert. Die Emissionen aller Treibhausgase duerften 2016 um rund 0,4% (knapp 4 Mio. t) zugenommen bzw. temperaturbereinigt fast auf dem Vorjahresniveau verharrt haben. Unabhaengig von der Einschaetzung nach den Veraenderungen der Ursprungswerte oder der temperaturbereinigten Werte ist auch 2016 der bis 2020 angestrebte Zielpfad deutlich verfehlt worden. Dazu haetten die unbereinigten Treibhausgasemissionen im Jahr 2016 um rund 3,6 % oder um etwa 30 Mio. t sinken muessen. Um das Reduktionsziel von 40 % bis 2020 noch zu erreichen, muessen die Emissionen in den 4 Jahren von 2017 bis 2020 jedes Jahr um nahezu 39 Mio. t CO{sub 2}-Aequivalente gesenkt werden. Ein erheblicher klimaschutzpolitischer Handlungsbedarf ist evident.

  6. Particle reduction strategies - PAREST. Evaluation of emission reduction scenarios using chemical transport calculations. PM10- and NO{sub 2}-immission contributions in Germany. Wood combustion in small combustion systems; installations of the 13th and 17th BImSchV (Federal Immission Control Act). Sub-report.; Strategien zur Verminderung der Feinstaubbelastung - PAREST. Bewertung von Emissionsminderungsszenarien mit Hilfe chemischer Transportberechnungen. PM10- und NO{sub 2}-Immissionsbeitraege in Deutschland. Holzverbrennung in Kleinfeuerungsanlagen, Anlagen der 13. und 17. BImSchV. Teilbericht

    Energy Technology Data Exchange (ETDEWEB)

    Stern, Rainer [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie, Troposphaerische Umweltforschung

    2013-06-15

    This report was prepared within the research project ''Particle reduction strategies - PAREST.'' In this paper with the chemical transport model REM CALGRID following questions were investigated: 1 What is the contribution of the wood-fired small combustion plants in Germany to the PM10- and NO {sub 2}-concentrations? 2 What is the contribution of the 13th and 17th BlmSchV covered installations to the PM10 and NO{sub 2} concentrations in Germany? [German] Der vorliegende Bericht wurde im Rahmen des Forschungs- und Entwicklungsvorhabens ''Strategien zur Verminderung der Feinstaubbelastung'' erstellt. In dem Beitrag werden mit dem chemischen Transportmodell REM-CALGRID folgende Fragestellungen untersucht: 1. Wie hoch ist der Beitrag der mit Holz beheizten Kleinfeuerungsanlagen in Deutschland zu den PM10- und den NO{sub 2}-Konzentrationen? 2. Wie hoch ist der Beitrag der von der 13. und 17. BImSchV erfassten Anlagen zu den PM10-und NO-2-Konzentrationen in Deutschland?.

  7. Nachbar zweier deutscher Staaten. Dänemark, die Bundesrepublik und die DDR

    DEFF Research Database (Denmark)

    Lammers, Karl Christian

    Artiklen omhandler den danske politik over for de to tyske stater fra 1949. Danmark var eneste NATO- land, der under den Kolde Krig havde grænser til begge tyske stater, og det stillede Danmark i en særlig position.   The article treats with Danish politics towards the two German states after 194...

  8. Performance assessment of a nested-PCR assay (the RAPID BAP-MTB) and the BD ProbeTec ET system for detection of Mycobacterium tuberculosis in clinical specimens.

    Science.gov (United States)

    Wang, Jann-Yuan; Lee, Li-Na; Chou, Chin-Sheng; Huang, Chung-Yi; Wang, Shu-Kuan; Lai, Hsin-Chih; Hsueh, Po-Ren; Luh, Kwen-Tay

    2004-10-01

    The performance of a nested PCR-based assay (the RAPID BAP-MTB; AsiaGen, Taichung, Taiwan) and the BD ProbeTec ET (DTB) system (Becton Dickinson, Sparks, Md.) for detection of Mycobacterium tuberculosis was evaluated with 600 consecutive clinical samples. These samples, including 552 respiratory specimens and 48 nonrespiratory specimens, were collected from 333 patients treated at National Taiwan University Hospital from September to October 2003. The results of both assays were compared to the gold standard of combined culture results and clinical diagnosis. The overall sensitivity and specificity of the RAPID BAP-MTB assay for respiratory specimens were 66.7% and 97.2%, respectively, and for the DTB assay they were 56.7% and 95.3%, respectively. The positive and negative predictive values for the RAPID BAP-MTB were 74.1% and 96.0%, respectively, and for the DTB assay they were 59.6% and 94.7%, respectively. For smear-negative samples, the sensitivity of the RAPID BAP-MTB and DTB assays was 57.1% and 40.5%, respectively. The RAPID BAP-MTB assay produced 14 false-positive results in 14 samples, including one of the six samples yielding Mycobacterium abscessus, one of the six samples yielding Mycobacterium avium intracellulare, one sample from a patient with a history of pulmonary tuberculosis with complete treatment, and three samples from three patients with a previous diagnosis of tuberculosis who were under treatment at the time of specimen collection. Among the 48 nonrespiratory specimens, the RAPID BAP-MTB assay was positive in one biopsy sample from a patient with lumbar tuberculous spondylitis and one pus sample from a patient with tuberculous cervical lymphadenopathy. Our results showed that the RAPID BAP-MTB assay is better than the DTB assay for both respiratory specimens and nonrespiratory specimens. The overall time for processing this assay is only 5 h. In addition, its diagnostic accuracy in smear-negative samples is as high as in smear

  9. The Pedotopia Project: A Transdisciplinary Experiment in Soil Education

    Science.gov (United States)

    Toland, A.; Wessolek, G.

    2012-04-01

    as a platform for the production of new soil-oriented artworks. An exhibition of the resulting works as well as a symposium on the cultural values of soil conservation was held at the annual meeting of the German Soil Science Society (DBG) in 2011 in Berlin. In the following paper we will present the Pedotopia project as a case study in transdisciplinary soil education. We will highlight main points of the curriculum, present the results of the project and address challenges and future considerations of transdisciplinary soil education. SOURCES FELLER, LARDY and UGOLINI (2010): The Representation of Soil in the Western Art: From Genesis to Pedogenesis. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 3-21 SZLEZAK, E. (2009) "Soilart with the Colours of the Earth". In: Amt der NÖ LandesregierungAbteilung Landentwicklung. Stand 2009. http://www.soilart.eu/1-0-Home.htm (abgerufen am 20. Dezember 2011) TOLAND, A. & WESSOLEK, G. (2010): Merging Horizons - Soil Science and Soil Art. In: Feller and Landa (Hrsg.) Soil and Culture. Dordrecht, Heidelberg, London and New York: Springer Science + Business Media B.V.: 45-66 WAGNER, M. (2002): Erde als Material künstlerische Gestaltung. In: BUSCH, B. (2002) (Hrsg.): Erde. Schriftenreihe Forum, Bd. 11, Elemente des Naturhaushalts III. Kunst- und Ausstellungshalle der Bundesrepublik Deutschland GmbH, Köln, 246-260

  10. To BD or not to BD: functional neuroimaging and the boundaries of bipolarity.

    Science.gov (United States)

    Kuiper, Sandy; McLean, Loyola; Malhi, Gin S

    2013-01-01

    Bipolar disorders are major mood disorders defined by the presence of discrete episodes of depression and either mania, in bipolar I disorder, or hypomania, in bipolar II disorder. There is little contention that both are serious psychiatric conditions or that they are associated with substantial suffering, disability, risk of suicide and cost to the community. Recently, focus has shifted away from classic manic-depressive illness toward a 'bipolar spectrum' model, which allows for much softer presentations to be conceptualized as bipolarity, but the boundaries of this concept remain contentious. In this article, we will consider the contribution of neuroimaging to delineating the bipolar phenotype and differentiating it from similar disorders.

  11. Prompt detection of influenza A and B viruses using the BD Veritor™ System Flu A+B, Quidel® Sofia® Influenza A+B FIA, and Alere BinaxNOW® Influenza A&B compared to real-time reverse transcription-polymerase chain reaction (RT-PCR).

    Science.gov (United States)

    Dunn, Jim; Obuekwe, Joy; Baun, Traci; Rogers, Justin; Patel, Twinkle; Snow, Linda

    2014-05-01

    The performance characteristics of rapid influenza diagnostic tests vary widely. This study evaluated the BD Veritor™ System Flu A+B (Veritor; BD Diagnostics, Sparks, MD, USA), Quidel® Sofia® Influenza A+B FIA (Sofia; Quidel Corp., San Diego, CA, USA), and Alere BinaxNOW® Influenza A&B (Binax; Alere Scarborough, Inc., Scarborough, ME, USA) compared to reverse transcription-polymerase chain reaction (RT-PCR) for detection of influenza viruses in nasal wash specimens from 240 pediatric patients. Positive percent agreements for influenza A and B virus detection were 93.8% and 94.2%, 95.8% and 98.1%, and 79.2% and 80.8% for Veritor, Sofia, and Binax, respectively. The Veritor and Binax tests demonstrated negative percent agreements >97.9% for detection of both influenza viruses, but the negative percent agreement of the Sofia test was 91.1% for influenza A and 70.7% for influenza B virus. Overall, the Veritor and Sofia tests were nearly as sensitive as RT-PCR and considerably more sensitive than Binax for detection of influenza viruses. However, the accuracy of the Sofia test was significantly lower than either Veritor or Binax.

  12. Interaction between cAMP, volume‑regulated anion channels and the Na+‑HCO3‑‑cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from isolated rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells.

    Science.gov (United States)

    Bulur, Nurdan; Crutzen, Raphael; Malaisse, Willy J; Sener, Abdullah; Beauwens, Renaud; Golstein, Philippe

    2013-05-01

    Soluble adenylyl cyclase (sAC) has been hypothesized to play a role in insulin secretion. The present study aimed to investigate the interaction between adenosine 3',5'‑cyclic monophosphate (cAMP), volume‑regulated anion channels (VRACs) and the electrogenic sodium bicarbonate (Na+‑HCO3‑) cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells. In the islets, 5‑nitro‑2‑(3‑phenylpropylamino)benzoic acid (NPPB) and 5‑chloro‑2‑hydroxy‑3‑(thiophene‑2‑carbonyl)indole‑1‑carboxamide (tenidap) reduced glucose‑stimulated insulin release, however, only NPPB suppressed the enhancing action of cAMP analogs upon such a release. Insulin output from the BRIN‑BD11 cells was stimulated by 2‑ketoisocaproate (KIC) or extracellular hypoosmolarity. cAMP analogs and 3‑isobutyl‑1‑methylxanthine increased the insulin output recorded in the isotonic medium to a greater relative extent than that in the hypotonic medium. The secretory response to KIC or hypotonicity was inhibited by NPPB or tenidap, which both also opposed the enhancing action of cAMP analogs. Inhibitors of mitogen‑activated protein (MAP) kinase decreased insulin output in isotonic and hypotonic media. The inhibitor of sAC, 2‑hydroxyestriol, caused only a modest inhibition of insulin release, whether in the isotonic or hypotonic medium, even when tested at a concentration of 100 µM. The omission of NaHCO3 markedly decreased the secretory response to KIC or extracellular hypotonicity. The omission of Na+ suppressed the secretory response to extracellular hypotonicity. The observations of the present study do not support the hypothesis of a major role for sAC in the regulation of insulin release.

  13. 'Torge, Wolfgang, Geschichte der Geodäsie in Deutschland'

    OpenAIRE

    Chassagnette, Axelle

    2013-01-01

    L’ouvrage de W. T. est l’œuvre d’un spécialiste de la géodésie et non d’un historien des sciences : que le lecteur n’y cherche ni problématique ni interrogation poussée sur les enjeux sociaux, politiques, pratiques ou intellectuels de la mesure de la Terre à travers les siècles. L’intention de l’auteur est de recenser les principales opérations d’arpentage et de géodésie menées en Allemagne depuis le XVIe siècle. Par géodésie, on entend la discipline qui associe la mesure des parties de la te...

  14. Restructuring power supply in Germany; Umstrukturierung der Stromversorgung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-05-15

    According to recent calculations of the Umweltbundesamt (Federal Environmental Office), all German nuclear power plants can be decommissioned from 2017. This will result neither in supply shortages nor in higher electricity rates, and Germany's climate protection goals will not be in danger either. There will be no need to import nuclear power from other countries. (orig.)

  15. Sustainable supply of biogas in Germany; Nachhaltige Biogasbereitstellung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Erler, Ronny [DBI - Gastechnologisches Institut gGmbH, Freiberg (Germany). Bereich Biogastechnologie; Ball, Thomas; Kiefer, Joachim [Technologiezentrum Wasser (Germany). Abt. Grundwasser und Boden; Dresen, Boris [Fraunhofer-Institut UMSICHT (Germany). Themenbereich Ressourcenmanagement; Koeppel, Wolfgang [DVGW-Forschungsstelle Karlsruhe (Germany). Gruppe Systeme und Netze

    2013-04-15

    The supply of certain substrates for biogas production is partly controversial discussed: 'Tank-or-plate' discussions, maize cultivation of the landscape and so forth. The research project 'Potential study for the sustainable production and supply of gaseous, renewable energy in Germany (Biogas Atlas)' examines the potentials of biogas production under consideration of various sustainability factors.

  16. Underground gas storage in Germany; Untertage-Gasspeicherung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-11-15

    The safe natural gas supply of Germany is guaranteed by imports, domestic delivery and underground natural gas storage facilities. More than 80 % of the consumed natural gas is imported. Due to new natural gas storage facilities as well as due to the extension of existing natural gas storage facilities, the storage of natural gas in Germany experiences an upward trend for years. This development especially experienced an enormous upswing in the last two years. The contribution under consideration reports on the status of the underground natural gas storage of crude oil products and petroleum products in Germany on the basis of the data of the Lower Saxony State Office for Mining, Energy and Geology (Hannover, FRG).

  17. Underground gas storage in Germany; Untertage-Gasspeicherung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2011-11-15

    The safe natural gas supply of Germany is guaranteed by imports, domestic delivery and underground natural gas storage facilities. More than 80 % of the consumed natural gas is imported. Due to new natural gas storage facilities as well as due to the extension of existing natural gas storage facilities, the storage of natural gas in Germany experiences an upward trend for years. The contribution under consideration reports on the status of the underground natural gas storage of crude oil products and petroleum products in Germany on the basis of the data of the Lower Saxony State Office for Mining, Energy and Geology (Hannover, Federal Republic of Germany).

  18. Walckenaeria simplex neu für Deutschland (Araneae, Linyphiidae

    Directory of Open Access Journals (Sweden)

    Kielhorn, Karl-Hinrich

    2008-07-01

    Full Text Available The rare money spider Walckenaeria simplex Chyzer, 1894 was found in 2007 near the city of Meißen (Germany on a rock overlooking the river Elbe. This is the northernmost occurrence of the species. W. simplex is distributed from Central to South Eastern Europe. The species is thermophilous and prefers wooded slopes with a southern exposition.

  19. Die zeitliche Entwicklung von Abschlussprüferhonoraren in Deutschland

    DEFF Research Database (Denmark)

    Laudemann, Heiko; Quick, Reiner; Schmidt, Florian

    2016-01-01

    Since 2005, German audit clients are obliged to publish auditor fees in the notes to their financial statements. the fees have to be differentiated into four categories: audit services, audit-ralated services, tax advisory services, and other services. Such a disclosure enables stakeholders...... to evaluate auditor independence. the paper analyses the temporal development of auditor fees as well as their composition for the period 2009-2013. Fees for audit services are by far the highest and decline over time. However, this development is exclusively driven by DAX30 Companies. With regard to auditor...... independene, the share of non-audit fees is critical for DAX30 but also for SDAX Companies....

  20. Oberflächennahe Geothermie - aktuelle rechtliche Situation in Deutschland

    Science.gov (United States)

    Hähnlein, Stefanie; Blum, Philipp; Bayer, Peter

    2011-06-01

    The use of shallow geothermal energy (laws, as for example the water act and mining act. Yet, there is no special law for shallow geothermal energy. Federal state laws, instructions and guidelines specify them. To restrict temperature anomalies only detached temperature thresholds and minimum distances exist. In this study relevant federal regulations are presented and discussed. In addition, an international overview on temperature thresholds for the groundwater and on minimum distances for ground source heat pump systems is given. It is recognizable that there are national and international only few regulations and that they are also heterogeneous. A fundamental revision is necessary to homogenize the legal situation and to avoid negative effects on the subsurface.