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Sample records for bunch profile diagnostics

  1. Infrared single shot diagnostics for the longitudinal profile of the electron bunches at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Delsim-Hashemi, Hossein

    2008-09-15

    The longitudinal profile of electron bunches plays an important role in the design of single-pass free electron lasers and future linear e{sup +}e{sup -} colliders. For the free electron laser FLASH in Hamburg, a longitudinal compression scheme is used which results in an asymmetric longitudinal bunch profile with a 'spike'. This 'spike', which has a very high peak current, is used in a high-gain SASE-FEL process to produce high intensity (about 70 {mu}J) femtosecond photon pulses in the XUV wavelength range. The required high peak current of the electron bunch is realized by confining a large number of electrons in a width, measured in time units, of few tens of femtosecond, making the diagnostics of such bunches a challenge. Furthermore, the operation of facilities such as FLASH shows that single-shot diagnostics is indispensable. It is intuitive to use a time domain method to measure the electron bunch length. However, when the structures present in the bunch profile fall in the femtoseconds range, this is beyond the resolution of time-resolved methods developed so far. In this thesis, a wavelength-domain technique is described that can fulfill both requirements of single shot and high resolution reaching to the femtoseconds range. The amount of charge that is confined in a typical length of several femtoseconds (FWHM of the spike) can be determined by a novel single-shot spectrometer that resolves the coherent radiation (e.g. coherent transition radiation) in the far-infrared and mid-infrared range. Furthermore the extension of this single-shot spectroscopy to shorter wavelengths reaching the near-infrared, makes it possible to investigate the presence of structures in the bunch profile that might correlate or anti-correlate to the SASE intensity. (orig.)

  2. Diagnostic technique applied for FEL electron bunches

    Science.gov (United States)

    Brovko, O.; Grebentsov, A.; Morozov, N.; Syresin, E.; Yurkov, M.

    2016-05-01

    Diagnostic technique applied for FEL ultrashort electron bunches is developed at JINR-DESY collaboration within the framework of the FLASH and XFEL projects. Photon diagnostics are based on calorimetric measurements and detection of undulator radiation. The infrared undulator constructed at JINR and installed at FLASH is used for longitudinal bunch shape measurements and for two-color lasing provided by the FIR and VUV undulators. The pump probe experiments with VUV and FIR undulators provide the bunch profile measurements with resolution of several femtosecond. The new three microchannel plates (MCP) detectors operated in X-ray range are under development now in JINR for SASE1-SASE 3 European XFEL.

  3. Adaptive method for electron bunch profile prediction

    Directory of Open Access Journals (Sweden)

    Alexander Scheinker

    2015-10-01

    Full Text Available We report on an experiment performed at the Facility for Advanced Accelerator Experimental Tests (FACET at SLAC National Accelerator Laboratory, in which a new adaptive control algorithm, one with known, bounded update rates, despite operating on analytically unknown cost functions, was utilized in order to provide quasi-real-time bunch property estimates of the electron beam. Multiple parameters, such as arbitrary rf phase settings and other time-varying accelerator properties, were simultaneously tuned in order to match a simulated bunch energy spectrum with a measured energy spectrum. The simple adaptive scheme was digitally implemented using matlab and the experimental physics and industrial control system. The main result is a nonintrusive, nondestructive, real-time diagnostic scheme for prediction of bunch profiles, as well as other beam parameters, the precise control of which are important for the plasma wakefield acceleration experiments being explored at FACET.

  4. Optical Bunch-By-Bunch Diagnostic System in KEK-PF

    CERN Document Server

    Mochihashi, M; Tanimoto, Y

    2001-01-01

    An optical bunch-by-bunch beam diagnostic system, which can detect oscillations of individual bunches in a multibunch operation, has been developed. The system is composed of a high-speed light shutter and an optical beamoscillation detector. The shutter that consists of a pockels cell and polarizers can be opened or closed in a bunch spacing time (2ns in KEK-PF) and it can select a light pulse corresponding to a certain bunch in a bunch train. The beam oscillation detector can detect oscillations of the pickedout bunch with a spectral analysis method. The diagnostic system has been installed in KEK-PF Beamline-21, and observed vertical oscillation of individual bunches due to an instability in the multi-bunch operation.

  5. Measuring the longitudinal bunch profile at CTF3

    CERN Document Server

    Dabrowski, A E; Bettoni, S; Braun†, H H; Corsini, R; Döbert, S; Egger, D; Lefevre, T; Rabiller, A; Shaker, H; Soby, L; Skowronski, P K; Tecker, F; Velasco, M

    2010-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration in order to test the feasibility of the proposed Compact Linear Collider (CLIC) two-beam acceleration scheme. The monitoring and control of the bunch length throughout the CTF3 complex is important since this affects the efficiency and the stability of the final RF power production process. Bunch length diagnostics therefore form an essential component of the beam instrumentation at CTF3. This paper presents longitudinal profile measurements based on Streak camera and non-destructive RF power and microwave spectrometry techniques.

  6. Electro-optic methods for longitudinal bunch diagnostics at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, B.R.

    2007-07-15

    Precise measurements of the temporal profile of sub-picosecond electron bunches are of high interest for the optimization and operation of VUV and X-ray free electron lasers. In this thesis, the shortest electro-optic signals measured so far for electron bunch diagnostics are presented, reaching a time resolution of better than 50 fs (rms). The e ects that introduce signal distortions and limit the time resolution are studied in numerical simulations for different electro-optic detection materials and techniques. The time resolution is mainly limited by lattice resonances of the electro-optic crystal. Electro-optic signals as short as 54 fs (rms) are obtained with gallium phosphide (GaP) crystals in a crossed polarizer detection scheme using temporally resolved electro-optic detection. Measuring near crossed polarization, where the electro-optic signal is proportional to the velocity field of the relativistic electron bunch, the shortest obtained signal width is 70 fs (rms). The electro-optic signals are compared to electron bunch shapes that are measured simultaneously with a transverse deflecting structure with 20 fs resolution. Numerical simulations using the bunch shapes as determined with the transverse deflecting cavity as input data are in excellent agreement with electro-optical signals obtained with GaP, both for temporally and spectrally resolved measurements. In the case of zinc telluride (ZnTe) the observed signals are slightly broader and significantly smaller than expected from simulations. These discrepancies are probably due to the poor optical quality of the available ZnTe crystals. (orig.)

  7. NEW DIAGNOSTICS AND CURES FOR COUPLED-BUNCH INSTABILITIES

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2002-08-06

    As circular accelerators move towards larger numbers of bunches and higher beam currents, the task of diagnosing and curing coupled-bunch instabilities becomes ever harder. This paper describes the use of phase space tracking, i.e. reconstruction of bunch phase space trajectories, as a comprehensive instability diagnostic. A new instability cure is also presented, based on recent insights into the dynamics of unevenly-filled rings. Data is shown from PEP-II and the ALS, where ''optimally shaped'' uneven fills have yielded significant increases in instability thresholds.

  8. New diagnostics and cures for coupled-bunch instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Prabhakar, S.

    2000-02-14

    Electromagnetic interaction between a charged particle beam and its surroundings causes collective instabilities, which must be controlled if the new light sources and colliders are to meet their design goals. Control requires a combination of passive damping and fast active feedback on an unprecedented technological scale. Efficient instability diagnosis techniques are also needed for machines with large numbers of bunches. This thesis describes new methods of measuring and analyzing coupled-bunch instabilities in circular accelerators, and demonstrates the existence of a new cure. A new technique is demonstrated for simultaneous measurement of growth rates, damping rates and coherent tune shifts of all unstable coupled-bunch eigenmodes from a single 10-25-ms transient snapshot of beam motion. The technique has been used to locate and quantify beam impedance resonances at PEP-II, ALS and SPEAR. This method is faster than existing spectral scan methods by at least an order of magnitude, and has the added advantage of revealing coupled-bunch dynamics in the linear small-signal regime. A method is also presented for estimating beam impedance from multi-bunch fill shape and synchronous phase measurements. Phase space tracking of multi-bunch instabilities is introduced as a ``complete instability diagnostic.'' Digitized multi-bunch data is analyzed offline, to estimate the phase space trajectories of bunches and modes. Availability of phase space trajectories is shown to open up a variety of possibilities, including measurement of reactive impedance, and diagnosis of the fast beam-ion instability. Knowledge gained from longitudinal measurements (all made using a digital longitudinal feedback system) has been used to optimize cavity temperatures, tuner positions and feedback parameters, and also to identify sources of beam noise at the three machines. A matrix-based method is presented for analyzing the beneficial effect of bunch-to-bunch tune variation on

  9. Temporal profile monitor based on electro-optic spatial decoding for low-energy bunches

    Directory of Open Access Journals (Sweden)

    Wei Wang

    2017-11-01

    Full Text Available The measurement of electron bunch temporal profile is one of the key diagnostics in accelerators, especially for ultrashort bunches. The electro-optic (EO technique enables the precise longitudinal characterization of bunch electric field in a single-shot and nondestructive way, which can simultaneously obtain and analyze the time jitter between the electron bunch and the synchronized laser. An EO monitor based on spatial decoding for temporal profile measurement and timing jitter recoding has recently been demonstrated and analyzed in depth for low-energy bunches at the Tsinghua Thomson scattering X-ray source. A detailed description of the experimental setup and measurement results are presented in this paper. An EO signal as short as 82 fs (rms is observed with 100  μm gallium phosphide for a 40 MeV electron bunch, and the corresponding length is 106 fs (rms with 300  μm zinc telluride. Owing to the field-opening angle, we propose a method to eliminate the influence of energy factor for bunches with low energy, resulting in a bunch length of ∼60  fs (rms. The monitor is also successfully applied to measure time jitter with approximately 10 fs accuracy. The experiment environment is proved to be the main source of the slow drift, which is removed using feedback control. Consequently, the rms time jitter decreases from 430 fs to 320 fs.

  10. A robust fibre laser system for electro-optic electron bunch profile measurements at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Wissmann, Laurens-Georg

    2012-08-15

    For the electro-optic measurement of electron bunch profiles at FLASH a robust ytterbium doped fibre laser (YDFL) system has been developed consisting of a laser oscillator and a two-staged amplifier. The oscillator is designed to meet the specifications of high reliability and low noise operation. The amplifier makes use of tailored nonlinearity to enhance the spectral bandwidth of the output laser pulses. Active repetition rate control enables sub-picosecond synchronisation of the laser to the accelerator reference RF. Using a two-stage gating scheme the output pulse train repetition rate is adopted to the accelerator repetition rate. An experimental site used for electro-optic electron bunch diagnostics has been redesigned to support single-shot bunch profile measurements based on spectral decoding. An existing bunch profile monitor with a similar laser system was upgraded and electro-optic bunch profile measurements were conducted, allowing for a comparison with measurements done with other longitudinal electron bunch diagnostics and with former measurements.

  11. Beam Diagnostics Based on Time-Domain Bunch-by-Bunch Data

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2000-03-30

    A bunch-by-bunch longitudinal feedback system has been used to control coupled-bunch longitudinal motion and study the behavior of the beam at ALS, SPEAR, PEP-II, and DAPHNE. Each of these machines presents unique challenges to feedback control of unstable motion and data analysis. Here the authors present techniques developed to adapt the feedback system to operating conditions at these accelerators. A diverse array of techniques has been developed to extract information on different aspects of beam behavior from the time-domain data captured by the feedback system. These include measurements of growth and damping rates of coupled-bunch modes, bunch-by-bunch current monitoring, measurements of bunch-by-bunch synchronous phases and longitudinal tunes, beam noise spectra. A technique is presented which uses the longitudinal feedback system to measure transverse growth and damping rates. Techniques are illustrated with data acquired at all of the four abovementioned machines.

  12. Modelling and measurements of bunch profiles at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Papadopoulou, S. [Crete U.; Antoniou, F. [Liverpool U.; Argyropoulos, T. [CERN; Fitterer, M. [Fermilab; Hostettler, M. [CERN; Papaphilippou, Y. [CERN

    2017-07-20

    The bunch profiles in the LHC are often observed to be non-Gaussian, both at Flat Bottom (FB) and Flat Top (FT) energies. Especially at FT, an evolution of the tail population in time is observed. In this respect, the Monte-Carlo Software for IBS and Radiation effects (SIRE) is used to track different types of beam distributions. The impact of the distribution shape on the evolution of bunch characteristics is studied. The results are compared with observations from the LHC Run 2 data.

  13. A Novel Diagnostics of Ultrashort Electron Bunches Based on Detection of Coherent Radiation from Bunched Electron Beam in an Undulator

    CERN Document Server

    Saldin, Evgeny L; Yurkov, Mikhail V

    2004-01-01

    We propose a new method for measurements of the longitudinal profile of 100 femtosecond electron bunches for X-ray Free Electron Lasers (XFELs). The method is based on detection of coherent undulator radiation produced by modulated electron beam. Seed optical quantum laser is used to produce exact optical replica of ultrashort electron bunches. The replica is generated in apparatus which consists of an input undulator (energy modulator), and output undulator (radiator) separated by a dispersion section. The radiation in the output undulator is excited by the electron bunch modulated at the optical wavelength and rapidly reaches a hundred-MW-level power. We then use the now-standard method of ultrashort laser pulse-shape measurement, a tandem combination of autocorrelator and spectrum (FROG -- frequency resolved optical gating) providing real-time single-shot measurements of the electron bunch structure. The big advantage of proposed technique is that it can be used to determine the slice energy spread and emi...

  14. Beam diagnostics based on time-domain bunch-by-bunch data

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, D.; Fox, J.; Hindi, H.; Limborg, C.; Linscott, I.; Prabhakar, S.; Sebek, J.; Young, A. [Stanford Linear Accelerator Center P.O. Box 4349 Stanford, California 94309 (United States); Drago, A.; Serio, M. [INFN-Laboratori Nazionali di Frascati, P.O. Box 13 I-00044 Frascati (Roma) (Italy); Barry, W.; Stover, G. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road Berkeley, California 94563 (United States)

    1998-12-01

    A bunch-by-bunch longitudinal feedback system has been used to control coupled-bunch longitudinal motion and study the behavior of the beam at ALS, SPEAR, PEP-II, and DA{Phi}NE. Each of these machines presents unique challenges to feedback control of unstable motion and data analysis. Here we present techniques developed to adapt this feedback system to operating conditions at these accelerators. A diverse array of techniques has been developed to extract information on different aspects of beam behavior from the time-domain data captured by the feedback system. These include measurements of growth and damping rates of coupled-bunch modes, bunch-by-bunch current monitoring, measurements of bunch-by-bunch synchronous phases and longitudinal tunes, and beam noise spectra. A technique is presented which uses the longitudinal feedback system to measure transverse growth and damping rates. Techniques are illustrated with data acquired at all of the four above-mentioned machines. {copyright} {ital 1998 American Institute of Physics.}

  15. Application of Metal-Semiconductor-Metal (MSM) Photodetectors for Transverse and Longitudinal Intra-Bunch Beam Diagnostics

    CERN Document Server

    Steinhagen, R J; Boland, M J; Lucas, T G; Rassool, R P

    2013-01-01

    The performance reach of modern accelerators is often governed by the ability to reliably measure and control the beam stability. In high-brightness lepton and high-energy hadron accelerators, the use of optical diagnostic techniques is becoming more widespread as the required bandwidth, resolution and high RF beam power level involved limit the use of traditional electro-magnetic RF pick-up based methods. This contribution discusses the use of fibre-coupled ultra-fast Metal-Semiconductor-Metal Photodetectors (MSM-PD) as an alternative, dependablemeans to measure signals derived from electro-optical and synchrotron-light based diagnostics systems. It describes the beam studies performed at CERN’s CLIC Test Facility (CTF3) and the Australian Synchrotron to assess the feasibility of this technology as a robust, wide-band and sensitive technique for measuring transverse intra-bunch and bunch-by-bunch beam oscillations, longitudinal beam profiles, un-bunched beam population and beam-halo profiles. The amplifica...

  16. Studies of longitudinal profile of electron bunches and impedance measurements at Indus-2 synchrotron radiation source

    Energy Technology Data Exchange (ETDEWEB)

    Garg, Akash Deep, E-mail: akash-deep@rrcat.gov.in [Beam Diagnostics Section (BDS), Indus Operations, Beam Dynamics and Diagnostics Division (IOBDD), Raja Ramanna Centre for Advanced Technology, Indore 452 013, M.P. (India); Homi Bhabha National Institute (HBNI) at Raja Ramanna Centre for Advanced Technology, Indore (India); Yadav, S.; Kumar, Mukesh; Shrivastava, B.B.; Karnewar, A.K.; Ojha, A.; Puntambekar, T.A. [Beam Diagnostics Section (BDS), Indus Operations, Beam Dynamics and Diagnostics Division (IOBDD), Raja Ramanna Centre for Advanced Technology, Indore 452 013, M.P. (India)

    2016-04-01

    Indus-2 is a 3rd generation synchrotron radiation source at the Raja Ramanna Centre for Advanced Technology (RRCAT) in India. We study the longitudinal profile of electrons in Indus-2 by using dual sweep synchroscan streak camera at visible diagnostic beamline. In this paper, the longitudinal profiles of electron bunch are analyzed by filling beam current in a single bunch mode. These studies are carried at injection energy (550 MeV) and at ramped beam energy (2.5 GeV). The effects of the wakefield generated interactions between the circulating electrons and the surrounding vacuum chamber are analyzed in terms of measured effects on longitudinal beam distribution. The impedance of the storage ring is obtained by fitting the solutions of Haissinski equation to the measured bunch lengthening with different impedance models. The impedance of storage ring obtained by a series R+L impedance model indicates a resistance (R) of 1350±125 Ω, an inductance (L) of 180±25 nH and broadband impedance of 2.69 Ω. These results are also compared with the values obtained from measured synchronous phase advancing and scaling laws. These studies are very useful in better understanding and control of the electromagnetic interactions.

  17. Transparent lattice characterization with gated turn-by-turn data of diagnostic bunch train

    Science.gov (United States)

    Li, Yongjun; Cheng, Weixing; Ha, Kiman; Rainer, Robert

    2017-11-01

    Methods of characterization of a storage ring's lattice have traditionally been intrusive to routine operations. More importantly, the lattice seen by particles can drift with the beam current due to collective effects. To circumvent this, we have developed a novel approach for dynamically characterizing a storage ring's lattice that is transparent to operations. Our approach adopts a dedicated filling pattern which has a short, separate diagnostic bunch train (DBT). Through the use of a bunch-by-bunch feedback system, the DBT can be selectively excited on demand. Gated functionality of a beam position monitor system is capable of collecting turn-by-turn data of the DBT, from which the lattice can then be characterized after excitation. As the DBT comprises only about one percent of the total operational bunches, the effects of its excitation are negligible to users. This approach allows us to localize the distributed quadrupolar wakefields generated in the storage ring vacuum chamber during beam accumulation. While effectively transparent to operations, our approach enables us to dynamically control the beta beat and phase beat, and unobtrusively optimize performance of the National Synchrotron Light Source-II accelerator during routine operations.

  18. Transparent lattice characterization with gated turn-by-turn data of diagnostic bunch train

    Directory of Open Access Journals (Sweden)

    Yongjun Li

    2017-11-01

    Full Text Available Methods of characterization of a storage ring’s lattice have traditionally been intrusive to routine operations. More importantly, the lattice seen by particles can drift with the beam current due to collective effects. To circumvent this, we have developed a novel approach for dynamically characterizing a storage ring’s lattice that is transparent to operations. Our approach adopts a dedicated filling pattern which has a short, separate diagnostic bunch train (DBT. Through the use of a bunch-by-bunch feedback system, the DBT can be selectively excited on demand. Gated functionality of a beam position monitor system is capable of collecting turn-by-turn data of the DBT, from which the lattice can then be characterized after excitation. As the DBT comprises only about one percent of the total operational bunches, the effects of its excitation are negligible to users. This approach allows us to localize the distributed quadrupolar wakefields generated in the storage ring vacuum chamber during beam accumulation. While effectively transparent to operations, our approach enables us to dynamically control the beta beat and phase beat, and unobtrusively optimize performance of the National Synchrotron Light Source-II accelerator during routine operations.

  19. Architectures and Algorithms for Control and Diagnostics of Coupled-Bunch Instabilities in Circular Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2003-07-08

    Modern light sources and circular colliders employ large numbers of high-intensity particle bunches in order to achieve high luminosity. The electromagnetic coupling of bunches via resonant structures causes coherent instabilities at high beam currents. Achieving high luminosity requires the control of such unstable motion. Feedback control is challenging due to wideband nature of the problem with up to 250 MHz bandwidths required. This thesis presents digital signal processing architectures and diagnostic techniques for control of longitudinal and transverse coupled-bunch instabilities. Diagnostic capabilities integrated into the feedback system allow one to perform fast transient measurements of unstable dynamics by perturbing the beam from the controlled state via feedback and recording the time-domain response. Such measurements enable one to thoroughly characterize plant (beam) dynamics as well as performance of the feedback system. Beam dynamics can change significantly over the operating range of accelerator currents and energies . Here we present several methods for design of robust stabilizing feedback controllers. Experimental results from several accelerators are presented. A new baseband architecture for transverse feedback is described that compactly implements the digital processing functions using field-programmable gate array devices. The architecture is designed to be software configurable so that the same hardware can be used for instability control in different accelerators.

  20. Multi-Bunch Longitudinal Dynamics and Diagnostics via a Digital Feedback System at PEP-II, DAFNE, ALS and SPEAR

    Energy Technology Data Exchange (ETDEWEB)

    Fox, John D

    1999-04-19

    A bunch-by-bunch longitudinal feedback system based on a programmable DSP architecture is used to study coupled-bunch motion and its sources. Experimental results are presented from PEP-II, DA{Phi}NE, ALS and SPEAR to highlight the operational experience from 4 installations, plus show novel accelerator diagnostics possible with the digital processing system. Modal growth and damping rates are measured via short (20 ms) transient recordings for unstable and stable coupled-bunch modes. Data from steady-state measurements are used to identify unstable modes and noise-driven beam motion. A novel impedance measurement technique is presented which reveals the longitudinal impedance as a function of frequency. This technique uses the measured synchronous phase and charge of every bucket to calculate the impedance seen by the beam at revolution harmonics.

  1. A multi-channel THz and infrared spectrometer for femtosecond electron bunch diagnostics by single-shot spectroscopy of coherent radiation

    Energy Technology Data Exchange (ETDEWEB)

    Wesch, Stephan; Schmidt, Bernhard; Behrens, Christopher; Delsim-Hashemi, Hossein; Schmueser, Peter

    2011-08-15

    The high peak current required in free-electron lasers (FELs) is realized by longitudinal compression of the electron bunches to sub-picosecond length. In this paper, a frequency-domain diagnostic method is described that is capable of resolving structures in the femtosecond regime. A novel in-vacuum spectrometer has been developed for spectroscopy of coherent radiation in the THz and infrared range. The spectrometer is equipped with five consecutive dispersion gratings and 120 parallel readout channels; it can be operated either in short wavelength mode (5-44 {mu}m) or in long wavelength mode (45-430 {mu}m). Fast parallel readout permits the spectroscopy of coherent radiation from single electron bunches. Test measurements at the soft X-ray free-electron laser FLASH, using coherent transition radiation, demonstrate excellent performance of the spectrometer. The high sensitivity down to a few micrometers allows study of short bunch features caused for example by microbunching e ects in magnetic chicanes. The device is planned for use as an online bunch profile monitor during regular FEL operation. (orig.)

  2. Mitigation of the electron-cloud effect in the PSR and SNS protonstorage rings by tailoring the bunch profile

    CERN Document Server

    Pivi, M T

    2003-01-01

    For the storage ring of the Spallation Neutron Source (SNS) at Oak Ridge, and for the Proton Storage Ring (PSR) at Los Alamos, both with intense and very long bunches, the electron cloud develops primarily by the mechanism of trailing-edge multipacting. We show, by means of simulations for the PSR, how the resonant nature of this mechanism may be effectively broken by tailoring the longitudinal bunch profile at fixed bunch charge, resulting in a significant decrease in the electron-cloud effect. We briefly discuss the experimental difficulties expected in the implementation of this cure.

  3. Tailored electron bunches with smooth current profiles for enhanced transformer ratios in beam-driven acceleration

    Directory of Open Access Journals (Sweden)

    F. Lemery

    2015-08-01

    Full Text Available Collinear high-gradient O(GV/m beam-driven wakefield methods for charged-particle acceleration could be critical to the realization of compact, cost-efficient, accelerators, e.g., in support of TeV-scale lepton colliders or multiple-user free-electron laser facilities. To make these options viable, the high accelerating fields need to be complemented with large transformer ratios >2, a parameter characterizing the efficiency of the energy transfer between a wakefield-exciting “drive” bunch to an accelerated “witness” bunch. While several potential current distributions have been discussed, their practical realization appears challenging due to their often discontinuous nature. In this paper we propose several alternative continuously differentiable (smooth current profiles which support enhanced transformer ratios. We especially demonstrate that one of the devised shapes can be implemented in a photo-emission electron source by properly shaping the photocathode-laser pulse. We finally discuss a possible superconducting linear-accelerator concept that could produce shaped drive bunches at high-repetition rates to drive a dielectric-wakefield accelerator with accelerating fields on the order of ∼60  MV/m and a transformer ratio ∼5 consistent with a recently proposed multiuser free-electron laser facility.

  4. SPARC Working Point Optimization for a Bunch with Gaussian Temporal Profile

    CERN Document Server

    Boscolo, Manuela; Fusco, Valeria; Migliorati, Mauro; Reiche, Sven; Ronsivalle, Concetta

    2005-01-01

    We present the optimization of the working point for the SPARC photoinjector with a Gaussian temporal profile. The implications of a Gaussian temporal profile are discussed here for the standard working conditions and for the RF compressor case in comparison with the nominal working point performances of a 10ps flat top pulse with rise time of 1ps. Comparisons with the upgraded version of the HOMDYN code including arbitrary bunch temporal profiles are also reported. Advantages and drawbacks of the Gaussian and flat top pulse shapes are discussed. For the standard working point, it is shown that the two cases provide the same saturation length and average power, but the higher current in the beam core of the Gaussian pulse gives a higher peak radiation power. As the laser pulse shape could be Gaussian at the first stage of the SPARC operation, it is clear the importance of these simulation results.

  5. Accelerator Diagnostic Techniques Using Time-Domain Data from a Bunch-by-bunch Longitudinal Feedback System

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2000-03-30

    A programmable DSP-based longitudinal damping system has been developed for the PEP-II/DAFNE/ALS machines. The DSP-based architecture allows feedback functions to coexist with data acquisition or instrumentation algorithms. The fast sampling rates in these systems (500 MHz) in conjunction with the large distributed memory of the DSP processors make possible several novel beam diagnostics complementary to traditional narrowband spectral measurements. Instantaneous spectral measurements of 250 MHz span with 70 Hz resolution can be made from 14 ms time domain data records captured by the DSP system. The authors present techniques developed for the measurement of modal growth and damping rates and other beam and system diagnostics (calibrations, measurements of the system noise floor). Results from the Advanced Light Source and PEP-II are presented to illustrate these techniques.

  6. Electron Beam Probe As A Nondestructive Single Bunch Diagnostic Tool For Circular Colliders

    CERN Document Server

    Logatchev, P V; Dikanskij, N S; Frolov, A R; Gusev, Y A; Malutin, D A; Starostenko, A A

    2004-01-01

    In this article we present the experience of using electron beam probe (EBP) on VEPP-4. EBP is destined to determine such parameters of ultrarelativistic bunches of charged particles as centre of mass transverse position, longitudinal charge distribution, spatial orientation. The method is based on a deflection of a thin probe beam on an electromagnetic field of investigated ultrarelativistic bunch. Measured deflection value allows to calculate the spatial charge density. Detailed description of methods for reconstruction of bunch's parameters is presented in [1], [2], [3].

  7. Nondestructive diagnostic for electron bunch length in accelerators using the wakefield radiation spectrum

    Directory of Open Access Journals (Sweden)

    S. V. Shchelkunov

    2005-06-01

    Full Text Available We report the development of a nondestructive technique to measure bunch rms length in the psec range and below, and eventually in the fsec range, by measuring the high-frequency spectrum of wakefield radiation which is caused by the passage of a relativistic electron bunch through a channel surrounded by a dielectric. We demonstrate numerically that the generated spectrum is determined by the rms bunch length, while the specific axial and longitudinal charge distribution is not important. Measurement of the millimeter-wave spectrum will determine the rms bunch length in the psec range. This has been done using a series of calibrated mesh filters and the charge bunches produced by the 50 MeV rf linac system at ATF (Accelerator Test Facility, Brookhaven. We have developed the analysis of the factors crucial for achieving good accuracy in this measurement, and find the experimental data are fully understood by the theory. We point out that this technique also may be used for measuring fsec bunch lengths, using a prepared planar wakefield microstructure.

  8. A Multiband-Instability-Monitor for High-Frequency Intra-Bunch Beam Diagnostics

    CERN Document Server

    Steinhagen, R J; Lucas, T G

    2013-01-01

    The maximum beam particle intensity and minimum emittance that can be injected, accelerated and stored in high-brightness lepton as well as high-energy hadron accelerators is fundamentally limited by self-amplifying beam instabilities, intrinsic to unavoidable imperfections in accelerators. Traditionally, intra-bunch or head-tail particle motion has been measured using fast digitizers, with even using state-of-the-art technology being limited in their effective intra-bunch position resolution to few tens of um in the multi-GHz regime. To improve on the present signal processing, a multiband-instability-monitor (MIM) prototype system has been designed, constructed and tested at the CERN Super- Proton-Synchrotron (SPS) and Large Hadron Collider (LHC). The system splits the signal into multiple equallyspaced narrowfrequency bands that are processed and analysed in parallel. Working with narrow-band signals permits the use of much higher resolution analogue-to-digitalconverters that can be used to resolve nm-scal...

  9. Research and development to complete construction of a setup for determination of the longitudinal profile and duration of ultrashort bunches. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gazazian, E.D.; Ivanian, M.I.; Laziev, E.M. [Yerevan Physics Inst., Erevan (Armenia); Avakian, R.A.; Mailian, A.E.; Oganessian, D.L.; Vardanian, A.O. [Yerevan Research Inst. for Optical and Physical Measurement (Armenia)

    1995-03-01

    Here are presented the results of the authors investigations on the construction of a setup for determination of the longitudinal charge distribution function and duration of ultrashort electron bunches via the measurement of the time-profile of the bunch-generated optical transition radiation (OTR) burst. In the Theoretical Part of the Final Report are obtained conditions that determine the adequacy between the time-profile of OTR flash and bunch longitudinal charge distribution function with account of finiteness of the bunch cross-section and bandwidth of the receiver. The competing processes (bremsstrahlung, luminescence) as well as the boundary roughness effect are considered. The Experimental Part presents the justification for the choice of the target - an OTR-emitter, a description of the measurement scheme, and the main characteristics of the units the setup consists of. An account is given of the OTR simulator and of the setup calibration method. Demands are formulated both to the setup as a whole and to its units. Experimental results are given that confirm correctness of the chosen method. In the Appendix the authors consider alternative methods of solution of the problem posed.

  10. Hollow bunches production

    CERN Document Server

    Hancock, S

    2017-01-01

    Hollow bunches address the issue of high-brightnessbeams suffering from transverse emittance growth in a strongspace charge regime. During the Proton Synchrotron (PS)injection plateau, the negative space charge tune shift canpush the beam onto theQy=6integer resonance. Modify-ing the longitudinal bunch profile in order to reduce the peakline charge density alleviates the detrimental impact of spacecharge. To this end we first produce longitudinally hollowphase space distributions in the PS Booster by exciting aparametric resonance with the phase loop feedback system.These inherently flat bunches are then transferred to the PS,where the beam becomes less prone to the emittance growthcaused by the integer resonance.During the late 2016 machine development sessions inthe PS Booster we profited from solved issues from 2015and managed to reliably extract hollow bunches of1.3eVsmatched longitudinal area. Furthermore, first results to cre-ate hollow bunches with larger longitudinal emittances to-wards the LHC Inject...

  11. Modelling and Measurements of Bunch Profiles at the LHC Flat Bottom

    CERN Document Server

    Papadopoulou, Stefania; Muller, Juan; Papaphilippou, Yannis; Trad, Georges

    2016-01-01

    At the LHC flat bottom the interplay between a series of effects (i.e. intrabeam scattering, longitudinal beam manipulations, non-linearities of the machine, etc) can lead to a population of the tails of the beam distributions, which may become non-Gaussian. This paper presents observations of the evolution of particle distributions in the LHC flat bottom. Novel distribution functions are employed to represent the beam profiles, and used as a guideline for generalising emittance growth rate estimations due to IBS. Finally, an attempt is made to benchmark an IBS Monte-Carlo simulation code, able to track 3D particle distributions, with the measured beam profile evolutions.

  12. Measurement of Sub-Picosecond Electron Bunches via Electro-Optic Sampling of Coherent Transition Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Timothy John [Northern Illinois U.

    2012-01-01

    Future collider applications as well as present high-gradient laser plasma wakefield accelerators and free-electron lasers operating with picosecond bunch durations place a higher demand on the time resolution of bunch distribution diagnostics. This demand has led to significant advancements in the field of electro-optic sampling over the past ten years. These methods allow the probing of diagnostic light such as coherent transition radiation or the bunch wakefields with sub-picosecond time resolution. We present results on the single-shot electro-optic spectral decoding of coherent transition radiation from bunches generated at the Fermilab A0 photoinjector laboratory. A longitudinal double-pulse modulation of the electron beam is also realized by transverse beam masking followed by a transverse-to-longitudinal phase-space exchange beamline. Live profile tuning is demonstrated by upstream beam focusing in conjunction with downstream monitoring of single-shot electro-optic spectral decoding of the coherent transition radiation.

  13. A Bunch-By-Bunch and Turn-By-Turn Instrumentation Hardware Upgrade for CESR-c

    CERN Document Server

    Palmer, Mark A; Strohman, Charles R; Tanke, Eugene

    2005-01-01

    A key factor in the colliding beam performance of the Cornell Electron Storage Ring (CESR) is the impact of parasitic beam-beam interactions between bunches in the two beams as they follow their electrostatically separated orbits in a single vacuum chamber. In order to better investigate the differential performance of bunches in CESR, instrumentation electronics has been developed to allow acquisition of turn-by-turn data from multiple bunches simultaneously. The electronics consists of a standardized digital board centered around an Analog Devices TigerSHARC family digital signal processor, a communications interface, and an interface to the CESR Precision Timing System. Mated to these components is an analog front end and digitizer board which is customized for the particular diagnostic device of interest. Front ends have been developed for beam position monitor, luminosity monitor, and beam profile monitor applications. We describe the design and characterization of this new hardware.

  14. Multi-bunch Feedback Systems

    CERN Document Server

    Lonza, M.

    2014-12-19

    Coupled-bunch instabilities excited by the interaction of the particle beam with its surroundings can seriously limit the performance of circular particle accelerators. These instabilities can be cured by the use of active feedback systems based on sensors capable of detecting the unwanted beam motion and actuators that apply the feedback correction to the beam. Advances in electronic technology now allow the implementation of feedback loops using programmable digital systems. Besides important advantages in terms of flexibility and reproducibility, digital systems open the way to the use of novel diagnostic tools and additional features. We first introduce coupled-bunch instabilities, analysing the equation of motion of charged particles and the different modes of oscillation of a multi-bunch beam, showing how they can be observed and measured. Different types of feedback systems will then be presented as examples of real implementations that belong to the history of multi-bunch feedback systems. The main co...

  15. Coherent-Radiation Spectroscopy of Few-Femtosecond Electron Bunches Using a Middle-Infrared Prism Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, T. J.; Behrens, C.; Ding, Y.; Fisher, A. S.; Frisch, J.; Huang, Z.; Loos, H.

    2013-10-28

    Modern, high-brightness electron beams such as those from plasma wakefield accelerators and free-electron laser linacs continue the drive to ever-shorter bunch durations. In low-charge operation ( ~ 20 pC ), bunches shorter than 10 fs are reported at the Linac Coherent Light Source (LCLS). Though suffering from a loss of phase information, spectral diagnostics remain appealing as compact, low-cost bunch duration monitors suitable for deployment in beam dynamics studies and operations instrumentation. Progress in middle-infrared (MIR) imaging has led to the development of a single-shot, MIR prism spectrometer to characterize the corresponding LCLS coherent beam radiation power spectrum for few-femtosecond scale bunch length monitoring. In this Letter, we report on the spectrometer installation as well as the temporal reconstruction of 3 to 60 fs-long LCLS electron bunch profiles using single-shot coherent transition radiation spectra.

  16. The Tevatron bunch by bunch longitudinal dampers

    Energy Technology Data Exchange (ETDEWEB)

    Cheng-Yang Tan and James Steimel

    2002-09-25

    We describe in this paper the Tevatron bunch by bunch dampers. The goal of the dampers is to stop the spontaneous longitudinal beam size blowup of the protons during a store. We will go through the theory and also show the measured results during the commissioning of this system. The system is currently operational and have stopped the beam blowups during a store.

  17. Precision Control of the Electron Longitudinal Bunch Shape Using an Emittance-Exchange Beam Line.

    Science.gov (United States)

    Ha, G; Cho, M H; Namkung, W; Power, J G; Doran, D S; Wisniewski, E E; Conde, M; Gai, W; Liu, W; Whiteford, C; Gao, Q; Kim, K-J; Zholents, A; Sun, Y-E; Jing, C; Piot, P

    2017-03-10

    We report on the experimental generation of relativistic electron bunches with a tunable longitudinal bunch shape. A longitudinal bunch-shaping (LBS) beam line, consisting of a transverse mask followed by a transverse-to-longitudinal emittance exchange (EEX) beam line, is used to tailor the longitudinal bunch shape (or current profile) of the electron bunch. The mask shapes the bunch's horizontal profile, and the EEX beam line converts it to a corresponding longitudinal profile. The Argonne wakefield accelerator rf photoinjector delivers electron bunches into a LBS beam line to generate a variety of longitudinal bunch shapes. The quality of the longitudinal bunch shape is limited by various perturbations in the exchange process. We develop a simple method, based on the incident slope of the bunch, to significantly suppress the perturbations.

  18. Recent Advances and New Techniques in Visualization of Ultra-short Relativistic Electron Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, Dao; /SLAC

    2012-06-05

    Ultrashort electron bunches with rms length of {approx} 1 femtosecond (fs) can be used to generate ultrashort x-ray pulses in FELs that may open up many new regimes in ultrafast sciences. It is also envisioned that ultrashort electron bunches may excite {approx}TeV/m wake fields for plasma wake field acceleration and high field physics studies. Recent success of using 20 pC electron beam to drive an x-ray FEL at LCLS has stimulated world-wide interests in using low charge beam (1 {approx} 20 pC) to generate ultrashort x-ray pulses (0.1 fs {approx} 10 fs) in FELs. Accurate measurement of the length (preferably the temporal profile) of the ultrashort electron bunch is essential for understanding the physics associated with the bunch compression and transportation. However, the shorter and shorter electron bunch greatly challenges the present beam diagnostic methods. In this paper we review the recent advances in the measurement of ultra-short electron bunches. We will focus on several techniques and their variants that provide the state-of-the-art temporal resolution. Methods to further improve the resolution of these techniques and the promise to break the 1 fs time barrier is discussed. We review recent advances in the measurement of ultrashort relativistic electron bunches. We will focus on several techniques and their variants that are capable of breaking the femtosecond time barrier in measurements of ultrashort bunches. Techniques for measuring beam longitudinal phase space as well as the x-ray pulse shape in an x-ray FEL are also discussed.

  19. Final Report on the Structural Strategy Diagnostic Profile Project.

    Science.gov (United States)

    Reigeluth, Charles M.; And Others

    The Structural Strategy Diagnostic Profile Project developed the elaboration model of instruction as a superior alternative to standard instructional sequencing based on hierarchical task analysis. The theory construction phase, the first of two phases, identified the instructional variables, postulated cause-effect relationships, and proposed…

  20. LHC MD 1279: Bunch Flattening in Physics

    CERN Document Server

    AUTHOR|(CDS)2073675; Baudrenghien, Philippe; Esteban Muller, Juan; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    Vertex reconstruction is not accurate enough for LHCb when the bunch length in physics shrinks below about 0.9 ns. The end-of-fill MD studies presented here proved that bunch flattening using sinusoidal RF modulation is a loss-free method to increase the r.m.s. bunch length and flatten the bunch profile. Furthermore, the optimum modulation parameters to be used in physics have been identified. Subsequently, bunch flattening in physics was used operationally with a modulation frequency of 98.75 % of the central synchrotron frequency and 0.6 modulation amplitude, resulting in a 150-200 ps increase in the BQM-measured bunch length. A ‘mid-of-fill’ test at arrival to flat top revealed that also the bunch distribution created by the controlled emittance blow-up during the ramp is affected when bunch flattening is applied. The measurements took place on 17th June and the 4th, 7th and 22nd July 2016. Operational cases are shown as well.

  1. Neutron emissivity profile camera diagnostics considering present and future tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Forsberg, S. [EURATOM-VR Association, Uppsala (Sweden)

    2001-12-01

    This thesis describes the neutron profile camera situated at JET. The profile camera is one of the most important neutron emission diagnostic devices operating at JET. It gives useful information of the total neutron yield rate but also about the neutron emissivity distribution. Data analysis was performed in order to compare three different calibration methods. The data was collected from the deuterium campaign, C4, in the beginning of 2001. The thesis also includes a section about the implication of a neutron profile camera for ITER, where the issue regarding interface difficulties is in focus. The ITER JCT (Joint Central Team) proposal of a neutron camera for ITER is studied in some detail.

  2. Beam Profile Diagnostics for the Fermilab Medium Energy Electron Cooler

    Science.gov (United States)

    Warner, A.; Kazakevich, G.; Nagaitsev, S.; Tassotto, G.; Gai, W.; Konecny, R.

    2005-10-01

    The Fermilab Recycler ring will employ an electron cooler to store and cool 8.9 GeV antiprotons. The cooler will be based on a Pelletron electrostatic accelerator working in an energy-recovery regime. Several techniques for determining the characteristics of the beam dynamics are being investigated. Beam profiles have been measured as a function of the beam line optics at the energy of 3.5 MeV in the current range of 10/sup -4/-1 A, with a pulse duration of 2 /spl mu/s. The profiles were measured using optical transition radiation produced at the interface of a 250-/spl mu/m aluminum foil and also from YAG crystal luminescence. In addition, beam profiles measured using multiwire detectors were investigated. These three diagnostics will be used together to determine the profile dynamics of the beam. In this paper we report the results so far obtained using these techniques.

  3. Space Charge Mitigation With Longitudinally Hollow Bunches

    CERN Multimedia

    Oeftiger, Adrian; Rumolo, Giovanni

    2016-01-01

    Hollow longitudinal phase space distributions have a flat profile and hence reduce the impact of transverse space charge. Dipolar parametric excitation with the phase loop feedback systems provides such hollow distributions under reproducible conditions. We present a procedure to create hollow bunches during the acceleration ramp of CERN’s PS Booster machine with minimal changes to the operational cycle. The improvements during the injection plateau of the downstream Proton Synchrotron are assessed in comparison to standard parabolic bunches.

  4. Space charge mitigation with longitudinally hollow bunches

    CERN Document Server

    AUTHOR|(CDS)2088716; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    Suitably, hollow longitudinal phase space distributions have a flat profile and hence reduce the impact of transverse space charge. Dipolar parametric excitation with the phase loop feedback systems provides such hollow distributions under reproducible conditions. We present a procedure to create hollow bunches during the acceleration ramp of CERN’s PS Booster machine with minimal changes to the operational cycle. The improvements during the injection plateau of the downstream Proton Synchrotron are assessed in comparison to standard parabolic bunches.

  5. Diagnostic criteria for CRPS I: differences between patient profiles using three different diagnostic sets.

    Science.gov (United States)

    Perez, Roberto S G M; Collins, Susan; Marinus, Johan; Zuurmond, Wouter W A; de Lange, Jaap J

    2007-11-01

    Complex Regional Pain Syndrome type I (CRPS I) is an illness which usually occurs due to major or minor tissue injury to the extremities. Because a unique pathophysiological mechanism for CRPS I has not yet been established, the diagnosis is based on observation and measurement of clinical symptoms and signs. In this study, a comparison was made between three sets of diagnostic criteria (the IASP, Bruehl et al. and Veldman et al.) based on patient reports and physicians' assessments of signs and symptoms associated with CRPS I, in 372 outpatients suspected of having CRPS I. Agreement between CRPS I diagnosis among the three sets was poor (kappa-range: 0.29-0.42), leading to positive CRPS I diagnoses according to Veldman et al.'s criteria in 218 cases (59%), according to the IASP in 268 cases (72%), and according to Bruehl et al. in 129 cases (35%). Significant differences in patient profiles were found between the diagnostic sets for the number of patients reporting continuing disproportionate pain, larger area affected than the initial trauma (both pCRPS I were found for reported hyperesthesia (SE+SP:165%), allodynia (160%), observed color asymmetry (162%), hyperesthesia (157%), temperature asymmetry (154%) and edema (152%). The lack of agreement between the different diagnostic sets for CRPS I and the different clinical profiles that result from it may lead to different therapeutic and study populations, hampering adequate treatment and scientific development for this illness. We propose explicit reference to diagnostic criteria used in studies, and registration in trials of a broad variety of CRPS I features, as used in this study, to make subgroup phenotyping and post hoc analyses based on different diagnostic criteria possible.

  6. Bucket shaking stops bunch dancing in Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Burov, A.; Tan, C.Y.; /Fermilab

    2011-03-01

    Bunches in Tevatron are known to be longitudinally unstable: their collective oscillations, also called dancing bunches, persist without any signs of decay. Typically, a damper is used to stop these oscillations, but recently, it was theoretically predicted that the oscillations can be stabilized by means of small bucket shaking. Dedicated measurements in Tevatron have shown that this method does stop the dancing. According to predictions of Refs. [2,3], the flattening of the bunch distribution at low amplitudes should make the bunch more stable against LLD. An experiment has been devised to flatten the distribution by modulating the RF phase at the low-amplitude synchrotron frequency for a few degrees of amplitude. These beam studies show that stabilisation really happens. After several consecutive shakings, the dancing disappears and the resulting bunch profile becomes smoother at the top. Although not shown in this report, sometimes a little divot forms at the centre of the distribution. These experiments confirm that resonant RF shaking flattens the bunch distribution at low amplitudes, and the dancing stops.

  7. KEKB bunch feedback systems

    Energy Technology Data Exchange (ETDEWEB)

    Tobiyama, M.; Kikutani, E. [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1996-08-01

    Design and the present status of the bunch by bunch feedback systems for KEKB rings are shown. The detection of the bunch oscillation are made with the phase detection for longitudinal plane, the AM/PM method for transverse plane. Two GHz component of the bunch signal which is extracted with an analog FIR filter is used for the detection. Hardware two-tap FIR filter systems to shift the phase of the oscillation by 90deg will be used for the longitudinal signal processing. The same system will be used with no filtering but with only digital delay for transverse system. The candidate for the kicker and the required maximum power are also estimated. (author)

  8. Diagnostic performance of the "MESACUP anti-Skin profile TEST".

    Science.gov (United States)

    Horváth, Orsolya N; Varga, Rita; Kaneda, Makoto; Schmidt, Enno; Ruzicka, Thomas; Sárdy, Miklós

    2016-01-01

    The "MESACUP anti-Skin profile TEST" is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays. The aim of this study was to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita. Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference. The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders.

  9. Externalising and emotional categories, diagnostic groups and clinical profiles

    Directory of Open Access Journals (Sweden)

    Bower Alison

    2010-07-01

    Full Text Available Abstract Background It has been proposed that gains would be made in the validity of the psychiatric classification system if many of the present 'neurotic' or personality disorders were subsumed into two over-arching groups, externalising and emotional disorders. If diagnostic sub-categories from the first digit coding structures within ICD-10 do, in fact, share clinical phenomenology that align with the major externalising/emotional distinction, this further supports the proposal and contributes to face validity. The aim of the study was to examine the distribution of particular psychopathology within and between two proposed over-arching groupings - externalising and emotional disorders - in a clinical sample. Method The distributions of HoNOS derived information in relation to the proposed clusters of emotional disorders and extrinsic disorders are examined. Results Statistically significant differences in profiles between the emotional and the externalising groupings are consistent with the proposed classification development. The HoNOS (Health of Nation Outcome Scale measures of self harm, depression, aggression, occupational/leisure problems and drug and alcohol consumption are the five most significant discriminators between the two groups. Discussion The details of the profile differences within the two over arching groups suggest that further examination is required. Useful work could include examination in credibly large and unselected patient populations of the factor structure demonstrated in non patient samples. Prospective comprehensive trials of the contributions the proposed classification could make to clinical decision making would also help illuminate this area.

  10. Development and commissioning of a double-prism spectrometer for the diagnosis of femtosecond electron bunches

    Energy Technology Data Exchange (ETDEWEB)

    Wunderlich, Steffen

    2016-12-15

    Free-electron lasers as accelerator-driven light sources and wakefield-based acceleration in plasmas require the knowledge of the longitudinal extension and the longitudinal current profile of the involved electron bunches. These bunches can yield lengths below 10 μm, or durations shorter than approx. 33 fs, as well as charges less than 30 pC. During this work, transition radiation from relativistic electron bunches was investigated in the mid-infrared wavelength regime. A spectrometer using an arrangement of two consecutive zinc selenide prisms was developed, built and commissioned. The instrument covers the spectral range from 2 μm to 18 μm in a single shot. Measurements with the double-prism spectrometer were conducted at the FEL facilities FLASH at DESY in Hamburg, Germany and FELIX at the Radboud Universiteit in Nijmegen, The Netherlands. The assessment of the spectrometer and comparative studies with established diagnostic devices at FLASH show high signal-to-noise ratios at bunch charges below 10 pC and confirm the obtained results.

  11. Status of the short bunch operation project at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Hass, Eugen; Kuhl, Alexander; Rossbach, Joerg [University of Hamburg (Germany); Rehders, Marie; Roensch-Schulenburg, Juliane [University of Hamburg (Germany); CFEL, Hamburg (Germany); Schlarb, Holger; Schreiber, Siegfried [DESY, Hamburg (Germany)

    2013-07-01

    The FEL FLASH (Free-Electron Laser in Hamburg) operates between 4.12 and 45 nm. Typically photon pulses between 50 and 200 fs are generated. Many users at FLASH work on pump-probe experiments, where time resolution is determined by the pulse duration. Therefore they have expressed a keen interest in being provided with shorter XUV pulses. The shortest possible SASE pulse is a single longitudinal optical mode of the FEL radiation. The most direct way to realize this at FLASH would be to reduce the electron bunch length to only a few μm at the entrance of the undulator section. In the ideal case a bunch charge of only 20 pC is suited for the generation of such short bunches. Thus a shorter initial bunch length at the photo-cathode can be chosen, which in turn reduces the bunch compression required to reach single mode conditions. A new photo-injector laser with adjustable pulse duration is used to optimize the initial electron bunch length. Beam dynamic studies are being performed to optimize the injection and compression of small charge electron bunches, starting with the pulse parameters of the injector laser. Improvements of important diagnostics are under way to adapt for charges and bunch lengths that are very small compared to standard FLASH operation. An overview and current status of the project is given in this contribution.

  12. Electron bunch length measurement at the Vanderbilt FEL

    Energy Technology Data Exchange (ETDEWEB)

    Amirmadhi, F.; Brau, C.A.; Mendenhall, M. [Vanderbilt Free-Electron-Laser Center, Nashville, TN (United States)] [and others

    1995-12-31

    During the past few years, a number of experiments have been performed to demonstrate the possibility to extract the longitudinal charge distribution from spectroscopic measurements of the coherent far-infrared radiation emitted as transition radiation or synchrotron radiation. Coherent emission occurs in a spectral region where the wavelength is comparable to or longer than the bunch length, leading to an enhancement of the radiation intensity that is on the order of the number of particles per bunch, as compared to incoherent radiation. This technique is particularly useful in the region of mm and sub-mm bunch lengths, a range where streak-cameras cannot be used for beam diagnostics due to their limited time resolution. Here we report on experiments that go beyond the proof of principle of this technique by applying it to the study and optimization of FEL performance. We investigated the longitudinal bunch length of the Vanderbilt FEL by analyzing the spectrum of coherent transition radiation emitted by the electron bunches. By monitoring the bunch length while applying a bunch-compression technique, the amount of the compression could be easily observed. This enabled us to perform a systematic study of the FEL performance, especially gain and optical pulse width, as a function of the longitudinal electron distribution in the bunch. The results of this study will be presented and discussed.

  13. Single Bunch Monopole Instability

    Energy Technology Data Exchange (ETDEWEB)

    Podobedov, B.; Heifets, S.; /SLAC

    2005-09-12

    We study single bunch stability with respect to monopole longitudinal oscillations in electron storage rings. Our analysis is different from the standard approach based on the linearized Vlasov equation. Rather, we reduce the full nonlinear Fokker-Planck equation to a Schroedinger-like equation which is subsequently analyzed by perturbation theory. We show that the Haissinski solution [3] may become unstable with respect to monopole oscillations and derive a stability criterion in terms of the ring impedance.

  14. Simultaneous detection of longitudinal and transverse bunch signals at ANKA

    Energy Technology Data Exchange (ETDEWEB)

    Kehrer, Benjamin; Blomley, Edmund; Brosi, Miriam; Bruendermann, Erik; Hiller, Nicole; Mueller, Anke-Susanne; Steinmann, Johannes; Schedler, Manuel; Schuh, Marcel; Schoenfeldt, Patrik; Smale, Nigel [Karlsruhe Institute of Technology, Karlsruhe (Germany); Schuetze, Paul [Deutsches Elektronen-Synchrotron DESY, Hamburg (Germany)

    2016-07-01

    The ANKA storage ring offers different operation modes including the short-bunch mode with bunch lengths tuned down to a few picoseconds. This can lead to the occurrence of microwave instabilities coupled to the emission of coherent synchrotron radiation (CSR) in the so-called 'bursts'. To study this CSR instability we use several turn-by-turn enabled detector systems to synchronously measure both the THz signal as well as bunch profiles. The different detectors are placed at different locations around the storage ring. Here we discuss the experimental setup and calibration of the various systems' synchronisation.

  15. Bunch Length and Impedance Measurements at SPEAR3

    Energy Technology Data Exchange (ETDEWEB)

    Corbett, W.J.; Cheng, W.X.; Fisher, A.S.; Huang, X.; /SLAC

    2011-11-02

    Streak camera measurements were made at SPEAR3 to characterize longitudinal coupling impedance. For the nominal optics, data was taken at three rf voltages and a single-bunch current range of 0-20mA. Both bunchcentroid phase shift and bunch lengthening were recorded to extract values for resistive and reactive impedance. An (R+L) and a Q=1 model were then back-substituted into the Haissinski equation and compared with raw profile data. In the short bunch (low-{alpha}) mode, distribution 'bursting' was observed.

  16. Longitudinal profile diagnostic scheme with subfemtosecond resolution for high-brightness electron beams

    Directory of Open Access Journals (Sweden)

    G. Andonian

    2011-07-01

    Full Text Available High-resolution measurement of the longitudinal profile of a relativistic electron beam is of utmost importance for linac based free-electron lasers and other advanced accelerator facilities that employ ultrashort bunches. In this paper, we investigate a novel scheme to measure ultrashort bunches (subpicosecond with exceptional temporal resolution (hundreds of attoseconds and dynamic range. The scheme employs two orthogonally oriented deflecting sections. The first imparts a short-wavelength (fast temporal resolution horizontal angular modulation on the beam, while the second imparts a long-wavelength (slow angular kick in the vertical dimension. Both modulations are observable on a standard downstream screen in the form of a streaked sinusoidal beam structure. We demonstrate, using scaled variables in a quasi-1D approximation, an expression for the temporal resolution of the scheme and apply it to a proof-of-concept experiment at the UCLA Neptune high-brightness injector facility. The scheme is also investigated for application at the SLAC NLCTA facility, where we show that the subfemtosecond resolution is sufficient to resolve the temporal structure of the beam used in the echo-enabled free-electron laser. We employ beam simulations to verify the effect for typical Neptune and NLCTA parameter sets and demonstrate the feasibility of the concept.

  17. Accelerator Technology: Beam Instrumentation and Diagnostics

    CERN Document Server

    Jones, R; Schmickler, H

    2013-01-01

    This document is part of Subvolume C 'Accelerators and Colliders' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the the Section '8.6 Beam Instrumentation and Diagnostics' of the Chapter '8 Accelerator Technology' with the content: 8.6 Beam Instrumentation and Diagnostics 8.6.1 Beam Position Measurement 8.6.2 Beam Current and Intensity Measurement 8.6.3 Diagnostics of Transverse Beam Motion 8.6.4 Beam Profile Measurements 8.6.5 Beam Loss Monitoring 8.6.6 Short Bunch Length Diagnostics

  18. Analysis of bunch by bunch oscillations with bunch trains at injection into LHC at 25 ns bunch spacing

    CERN Document Server

    Bartosik, H

    2012-01-01

    An MD on August 26, 2011 was dedicated to injection studies of bunch trains with 25 ns spacing and nominal intensity of approximately 1×10(11) protons per bunch. Due to an electrical glitch, the MD was stopped after two attempts of injecting a train of 48 bunches for beam 2. Both injections were aborted after less than 0.1 s. In particular, the first attempt with transverse damper on was dumped after 1000 turns while the second attempt with transverse damper off was dumped after 500 turns only. In this note, an analysis of the bunch by bunch oscillation data recorded with the post-mortem system from the transverse damper is presented. The presented data clearly shows the presence of instabilities that affect mainly the second half of the batch. This is compatible with what would be expected qualitatively in the presence of the electron cloud effect.

  19. CEBAF Upgrade Bunch Length Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Mahmoud [Old Dominion Univ., Norfolk, VA (United States)

    2016-05-01

    Many accelerators use short electron bunches and measuring the bunch length is important for efficient operations. CEBAF needs a suitable bunch length because bunches that are too long will result in beam interruption to the halls due to excessive energy spread and beam loss. In this work, bunch length is measured by invasive and non-invasive techniques at different beam energies. Two new measurement techniques have been commissioned; a harmonic cavity showed good results compared to expectations from simulation, and a real time interferometer is commissioned and first checkouts were performed. Three other techniques were used for measurements and comparison purposes without modifying the old procedures. Two of them can be used when the beam is not compressed longitudinally while the other one, the synchrotron light monitor, can be used with compressed or uncompressed beam.

  20. Expression Profiles and DNA-Binding Affinity of Five ERF Genes in Bunches of Vitis vinifera cv. Cardinal Treated with High Levels of CO2 at Low Temperature.

    Science.gov (United States)

    Romero, Irene; Vazquez-Hernandez, Maria; Escribano, M I; Merodio, Carmen; Sanchez-Ballesta, M T

    2016-01-01

    Ethylene response factors (ERFs) play an important role in plants by regulating defense response through interaction with various stress pathways. After harvest, table grapes (Vitis vinifera L.) are subject to a range of problems associated with postharvest storage at 0°C, such as fungal attack, water loss and rachis browning. The application of a 3-day high CO2 treatment maintained fruit quality and activated the induction of transcription factors belonging to different families such as ERF. In this paper, we have isolated five VviERFs from table grapes cv. Cardinal, whose deduced amino acid sequence contained the conserved apetalous (AP2)/ERF domain. The phylogeny and putative conserved motifs in VviERFs were analyzed and compared with those previously reported in Vitis. VviERFs-c gene expression was studied by quantitative real-time RT-PCR in the different tissues of bunches stored at low temperature and treated with high levels of CO2. The results showed that in most of the tissues analyzed, VviERFs-c gene expression was induced by the storage under normal atmosphere although the application of high levels of CO2 caused a greater increase in the VviERFs-c transcript accumulation. The promoter regions of two PRs (pathogenesis related proteins), Vcchit1b and Vcgns1, were obtained and the in silico analysis revealed the presence of a cis-acting ethylene response element (GCC box). In addition, expression of these two PR genes was analyzed in the pulp and rachis of CO2-treated and non-treated table grapes stored at 0°C and results showed significant correlations with VviERF2-c and VviERF6L7-c gene expression in rachis, and between VviERF11-c and Vcchit1b in pulp. Finally by using electro mobility shift assays, we denoted differences in binding of VviERFs to the GCC sequences present in the promoters of both PRs, with VviERF6L7-c being the only member which did not bind to any tested probe. Overall, our results suggest that the beneficial effect of high CO2

  1. Expression Profiles and DNA-Binding Affinity of Five ERF Genes in Bunches of Vitis vinifera cv. Cardinal Treated with High Levels of CO2 at Low Temperature

    Science.gov (United States)

    Romero, Irene; Vazquez-Hernandez, Maria; Escribano, M. I.; Merodio, Carmen; Sanchez-Ballesta, M. T.

    2016-01-01

    Ethylene response factors (ERFs) play an important role in plants by regulating defense response through interaction with various stress pathways. After harvest, table grapes (Vitis vinifera L.) are subject to a range of problems associated with postharvest storage at 0°C, such as fungal attack, water loss and rachis browning. The application of a 3-day high CO2 treatment maintained fruit quality and activated the induction of transcription factors belonging to different families such as ERF. In this paper, we have isolated five VviERFs from table grapes cv. Cardinal, whose deduced amino acid sequence contained the conserved apetalous (AP2)/ERF domain. The phylogeny and putative conserved motifs in VviERFs were analyzed and compared with those previously reported in Vitis. VviERFs-c gene expression was studied by quantitative real-time RT-PCR in the different tissues of bunches stored at low temperature and treated with high levels of CO2. The results showed that in most of the tissues analyzed, VviERFs-c gene expression was induced by the storage under normal atmosphere although the application of high levels of CO2 caused a greater increase in the VviERFs-c transcript accumulation. The promoter regions of two PRs (pathogenesis related proteins), Vcchit1b and Vcgns1, were obtained and the in silico analysis revealed the presence of a cis-acting ethylene response element (GCC box). In addition, expression of these two PR genes was analyzed in the pulp and rachis of CO2-treated and non-treated table grapes stored at 0°C and results showed significant correlations with VviERF2-c and VviERF6L7-c gene expression in rachis, and between VviERF11-c and Vcchit1b in pulp. Finally by using electro mobility shift assays, we denoted differences in binding of VviERFs to the GCC sequences present in the promoters of both PRs, with VviERF6L7-c being the only member which did not bind to any tested probe. Overall, our results suggest that the beneficial effect of high CO2

  2. Interaction of relativistic short proton bunches with space charge limited electron clouds

    Directory of Open Access Journals (Sweden)

    F. B. Petrov

    2014-12-01

    Full Text Available The electron cloud buildup and interaction with a train of relativistic, short proton bunches is studied using particle-in-cell codes. The simulation models describe the electron generation at the beam pipe wall as well as the wakefield behind the bunches. The study focuses on the space charge limited (saturated cloud profile between the bunches and on the incoherent tune spread caused by the interaction of the saturated cloud with individual bunches. Analytical expressions describing the pinch of a saturated electron cloud are derived and compared to simulation results.

  3. Flat bunches in the LHC

    CERN Document Server

    Shaposhnikova, E; Baudrenghien, P; Mastoridis, T; Muller, J E; Papotti, G; Salvant, B; Timko, H; Bhat, C; Burov, A

    2014-01-01

    A high harmonic RF system which could serve multiple purposes was proposed for the LHC. Possible applications of the second harmonic RF system include beam stabilisation in the longitudinal plane in absence of wide-band longitudinal feedback and reduction of bunch peak line density. Apart from other useful features flat bunches are expected to produce less beam-induced heating below 1 GHz, the frequency region critical for some LHC equipment. The latter however can also be achieved by de-populating the bunch center. This was demonstrated during the dedicated machine development session in the LHC using RF phase modulation. In this paper the results of tests with single bunches and nominal LHC beams are presented and possible use of this technique in LHC operation is discussed.

  4. Step Bunching and Solution Flow

    Science.gov (United States)

    Chernov, A. A.

    2003-01-01

    Imagine a sequence of equidistant steps parallel to one another on a crystal face growing from solution. Steps may be one or part of a lattice spacing high. With such ideal morphology, the most perfect material is expected to be produced. Sometimes this happens. Much more often, however, steps form bunches, acquire wavy shapes and interlace. With time, these spontaneous perturbations may be increased in amplitude, i.e. the stepped surface becomes morphologically unstable. Interferometric studies of Y.G. Kuznetsov, L.N. Rashkovich, P.G. Vekilov and N.A. Booth and the author demonstrated that the step bunching depends at least on direction and rate of solution flow over the interface, supersaturation and presence of impurities. In particular, if solution and step flow are parallel to one another, the steps convene into bunches. If these flows are antiparallel, the bunches disappear. As the step train propagates, the overall bunch height often increases infinitely. However, we have found recently that if the flow rate is large enough, (approximately 1 meter per second), the bunch height may be limited. All these phenomena come from interaction between steps. The interaction mechanisms are still not fully understood. I plan to overview major approaches to the still unresolved problem on how these dissipative structures on growing crystal face appear and evolve.

  5. Measuring the Bunch Frequency Multiplication at CTF3

    CERN Document Server

    Bettoni, S; Corsini, R; Dabrowski, A; Doebert, S; Egger, D; Ferrari, A; Lefevre, T; Rabiller, A; Skowronski, PK; Soby, L; Tecker, F; Welsch, CP

    2010-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the LINAC to a final bunch frequency of 12 GHz. The optimization procedure relies on several steps. The active length of each ring is carefully adjusted to within less than millimetre accuracy using a wiggler magnet. The transverse optics of the machine must be set up in a way to ensure beam isochronicity. Diagnostics based on optical Streak camera and RF power measurements have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents their performance and recent measurements

  6. Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors

    NARCIS (Netherlands)

    Kerkhofs, T. M. A.; Kerstens, M. N.; Kema, I. P.; Willems, T. P.; Haak, H. R.

    Radiological examination may unexpectedly reveal an adrenal mass. Current algorithms for differentiating between benign and malignant lesions mainly rely on size and densitometry on unenhanced CT, which have limited specificity. We examined the diagnostic value of urinary steroid profiling by gas

  7. Self-bunching electron guns

    CERN Document Server

    Mako, F; Weilhammer, Peter

    1999-01-01

    We report on three electron gun projects that are aimed at power tube and injector applications. The purpose of the work is to develop robust electron guns which produce self-bunched, high-current-density beams. We have demonstrated cold emission, long life, and tolerance to contamination. The cold emission process is based on secondary electron emission. FMT has studied this resonant bunching process which gives rise to high current densities (0.01-5 kA/cm/sup 2/), high charge bunches (up to 100 nC/bunch), and short pulses (1-100 ps) for frequencies from 1 to 12 GHz. The beam pulse width is nominally ~5% of the RF period. The first project is the L-Band Micro-Pulse Gun (MPG). Measurements show ~40 ps long microbunches at ~20 A/cm/sup 2/ without contamination due to air exposure. Lifetime testing has been carried out for about 18 months operating at 1.25 GHz for almost 24 hours per day at a repetition rate of 300 Hz and 5 mu s-long macro- pulses. About 5.8*10/sup 13/ micro-bunches or 62,000 coulombs have pass...

  8. Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn's Disease and Intestinal Tuberculosis.

    Directory of Open Access Journals (Sweden)

    Fenming Zhang

    Full Text Available To explore the diagnostic models of Crohn's disease (CD, Intestinal tuberculosis (ITB and the differential diagnostic model between CD and ITB by analyzing serum proteome profiles.Serum proteome profiles from 30 CD patients, 21 ITB patients and 30 healthy controls (HCs were analyzed by using weak cationic magnetic beads combined with MALDI-TOF-MS technique to detect the differentially expressed proteins of serum samples. Three groups were made and compared accordingly: group of CD patients and HCs, group of ITB patients and HCs, group of CD patients and ITB patients. Wilcoxon rank sum test was used to screen the ten most differentiated protein peaks (P < 0.05. Genetic algorithm combining with support vector machine (SVM was utilized to establish the optimal diagnostic models for CD, ITB and the optimal differential diagnostic model between CD and ITB. The predictive effects of these models were evaluated by Leave one out (LOO cross validation method.There were 236 protein peaks differently expressed between group of CD patients and HCs, 305 protein peaks differently expressed between group of ITB patients and HCs, 332 protein peaks differently expressed between group of CD patients and ITB patients. Ten most differentially expressed peaks were screened out between three groups respectively (P < 0.05 to establish diagnostic models and differential diagnostic model. A diagnostic model comprising of four protein peaks (M/Z 4964, 3029, 2833, 2900 can well distinguish CD patients and HCs, with a specificity and sensitivity of 96.7% and 96.7% respectively. A diagnostic model comprising four protein peaks (M/Z 3030, 2105, 2545, 4210 can well distinguish ITB patients and HCs, with a specificity and sensitivity of 93.3% and 95.2% respectively. A differential diagnostic model comprising three potential biomarkers protein peaks (M/Z 4267, 4223, 1541 can well distinguish CD patients and ITB patients, with a specificity and sensitivity of 76.2% and 80

  9. Bunch Compressor Beamlines for the Tesla and S Band Linear Colliders

    CERN Document Server

    Emma, P

    2003-01-01

    A detailed design for a single stage beam bunch length compressor for both the TESLA and the S-Band Linear Collider (SBLC) is presented. Compression is achieved by introducing an energy-position correlation along the bunch with an rf section at zero-crossing phase followed by a short bending section with energy dependent path length (momentum compaction). The motivation for a wiggler design is presented and many of the critical single bunch tolerances are evaluated. A solenoid based spin rotator is included in the design and transverse emittance tuning elements, diagnostics and tuning methods are described. Bunch length limitations due to second order momentum compaction and sinusoidal rf shape are discussed with options for compensation. Finally, the disadvantages of bunch compression using a 180 sup o arc are discussed.

  10. Data on multicultural education and diagnostic information profiling: Culture, learning styles and creativity.

    Science.gov (United States)

    Maseleno, Andino; Hardaker, Glenn; Sabani, Noraisikin; Suhaili, Nabilah

    2016-12-01

    This article contains data related to multicultural education and diagnostic information profiling preliminary findings. It includes the responses of 253 students. The data consists of six sections, i) culture: race, ethnicity, language and identity; ii) learning preferences: physiological and perceptual; iii) cognitive learning styles: physical, emotional and mental; iv) creativity skills and problem solving skills; v) motivation; and vi) students' background knowledge. The data may be used as part of data analytics for specific personalized e-learning platform.

  11. Data on multicultural education and diagnostic information profiling: Culture, learning styles and creativity

    Directory of Open Access Journals (Sweden)

    Andino Maseleno

    2016-12-01

    Full Text Available This article contains data related to multicultural education and diagnostic information profiling preliminary findings. It includes the responses of 253 students. The data consists of six sections, i culture: race, ethnicity, language and identity; ii learning preferences: physiological and perceptual; iii cognitive learning styles: physical, emotional and mental; iv creativity skills and problem solving skills; v motivation; and vi students’ background knowledge. The data may be used as part of data analytics for specific personalized e-learning platform.

  12. Measuring the electron bunch timing with femtosecond resolution at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Bock, Marie Kristin

    2013-03-15

    Bunch arrival time monitors (BAMs) are an integral part of the laser-based synchronisation system which is being developed at the Free Electron Laser in Hamburg (FLASH).The operation principle comprises the measurement of the electron bunch arrival time relative to the optical timing reference, which is provided by actively length-stabilised fibre-links of the synchronisation system. The monitors are foreseen to be used as a standard diagnostic tool, not only for FLASH but also for the future European X-Ray Free-Electron Laser (European XFEL). The present bunch arrival time monitors have evolved from proof-of-principle experiments to beneficial diagnostic devices, which are almost permanently available during standard machine operation. This achievement has been a major objective of this thesis. The developments went in parallel to improvements in the reliable and low-maintenance operation of the optical synchronisation system. The key topics of this thesis comprised the characterisation and optimisation of the opto-mechanical front-ends of both, the fibre-links and the BAMs. The extent of applications involving the bunch arrival time information has been enlarged, providing automated measurements for properties of the RF acceleration modules, for instance, the RF on-crest phase determination and the measurement of energy fluctuations. Furthermore, two of the currently installed BAMs are implemented in an active phase and gradient stabilisation of specific modules in order to minimise the arrival time jitter of the electron bunches at the location of the FEL undulators, which is crucial for a high timing resolution of pump-probe experiments.

  13. Formation of a novel shaped bunch to enhance transformer ratio in collinear wakefield accelerators

    Directory of Open Access Journals (Sweden)

    B. Jiang

    2012-01-01

    Full Text Available The transformer ratio, characterizing the ratio of maximum accelerating field behind the drive bunch to the maximum decelerating field inside the drive bunch, is one of the key parameters for characterizing the performance of collinear wakefield accelerators. In this paper the use of electron drive bunches possessing a particular temporal profile (the double-triangular bunch is shown to significantly increase the transformer ratio beyond 2, the limit for a symmetric bunch. The double-triangular bunch is generated using the emittance exchange technique [P. Emma et al., Phys. Rev. ST Accel. Beams 9, 100702 (2006]PRABFM1098-440210.1103/PhysRevSTAB.9.100702. Complete beam simulations have been performed for a collinear wakefield acceleration experiment planned at the Argonne Wakefield Accelerator facility including the effects of the physical emittance increase of the bunch in the wakefield device. A transformer ratio of 6.5 and gradient of 20  MV/m is expected in this proof-of-principle experiment for a 3 nC double-triangular bunch traversing a 10 cm long, 200 GHz quartz based dielectric wakefield accelerator structure.

  14. Optical measurement of the longitudinal ion distribution of bunched ion beams in the ESR

    Energy Technology Data Exchange (ETDEWEB)

    Wen, W.Q. [Institute of Modern Physics, Chinese Academy of Sciences, 730000 Lanzhou (China); GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); University of Chinese Academy of Sciences, 100049 Beijing (China); Lochmann, M. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Institut für Kernchemie, Universität Mainz, 55128 Mainz (Germany); Ma, X., E-mail: x.ma@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, 730000 Lanzhou (China); Bussmann, M. [Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden (Germany); Winters, D.F.A. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Nörtershäuser, W. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Institut für Kernchemie, Universität Mainz, 55128 Mainz (Germany); Institut für Kernphysik, Technische Universität Darmstadt, 64289 Darmstadt (Germany); Botermann, B. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Institut für Kernchemie, Universität Mainz, 55128 Mainz (Germany); Geppert, C.; Frömmgen, N.; Hammen, M. [Institut für Kernchemie, Universität Mainz, 55128 Mainz (Germany); Hannen, V.; Jöhren, R. [Institut für Kernphysik, Universität Münster, 48149 Münster (Germany); and others

    2013-05-21

    An optical technique to study the longitudinal distribution of ions in a bunched ion beam circulating in a storage ring is presented. It is based on the arrival-time analysis of photons emitted after collisional excitation of residual gas molecules. The beam-induced fluorescence was investigated in the ultraviolet regime with a channeltron and in the visible region using a photomultiplier tube. Both were applied to investigate the longitudinal shape of bunched and electron-cooled {sup 209}Bi{sup 80+} ion beams at about 400 MeV/u in the experimental storage ring (ESR) at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Bunch lengths were determined with an uncertainty of about 0.5 m using the UV-sensitive channeltron and with slightly lower accuracy from the photomultiplier data due to the slower transitions in the red region of the spectrum. The Gaussian shape of the longitudinal distribution of ions inside the bunch was confirmed. With the information of the transverse beam size that can be measured simultaneously by a newly installed ionization profile monitor (IPM) at the ESR, an accurate determination of the ion density in the bunched beam will be allowed. -- Highlights: ► Optical methods to measure the bunch shape of ion beam at storage ring. ► High resolution of bunch length was obtained from the UV-sensitive channeltron. ► The Gaussian shape of longitudinal distribution of the ions in the bunch was confirmed.

  15. Analysis of multi-bunch instabilities at the Diamond storage ring

    CERN Document Server

    Bartolini, Riccardo; Rehm, Guenther; Smaluk, Victor

    2017-01-01

    We present the result of the analytical, numerical and experimental analysis of multi-bunch instabilities at the Diamond storage ring. This work compares the impedance estimates with CST with the analysis of the growth rates of the excited multi-bunch modes in different machine configurations. The contribution of a number of wakefield sources has been identified with very high precision thanks to high quality data provided by the existing TMBF diagnostics.

  16. Cross-diagnostic validity of the Nottingham health profile index of distress (NHPD

    Directory of Open Access Journals (Sweden)

    Klevsgård Rosemarie

    2008-07-01

    Full Text Available Abstract Background The Nottingham Health Profile index of Distress (NHPD has been proposed as a generic undimensional 24-item measure of illness-related distress that is embedded in the Nottingham Health Profile (NHP. Data indicate that the NHPD may have psychometric advantages to the 6-dimensional NHP profile scores. Detailed psychometric evaluations are, however, lacking. Furthermore, to support the validity of the generic property of outcome measures evidence that scores can be interpreted in the same manner in different diagnostic groups are needed. It is currently unknown if NHPD scores have the same meaning across patient populations. This study evaluated the measurement properties and cross-diagnostic validity of the NHPD as a survey instrument among people with Parkinson's disease (PD and peripheral arterial disease (PAD. Methods Data from 215 (PD and 258 (PAD people were Rasch analyzed regarding model fit, reliability, differential item functioning (DIF, unidimensionality and targeting. In cases of cross-diagnostic DIF this was adjusted for and the impact of DIF on the total score and person measures was assessed. Results The NHPD was found to have good overall and individual item fit in both disorders as well as in the pooled sample, but seven items displayed signs of cross-diagnostic DIF. Following adjustment for DIF some aspects of model fit were slightly compromised, whereas others improved somewhat. DIF did not impact total NHPD scores or resulting person measures, but the unadjusted scale displayed minor signs of multidimensionality. Reliability was > 0.8 in all within- and cross-diagnostic analyses. Items tended to represent more distress (mean, 0 logits than that experienced by the sample (mean, -1.6 logits. Conclusion This study supports the within- and cross-diagnostic validity of the NHPD as a survey tool among people with PD and PAD. We encourage others to reassess available NHP data within the NHPD framework to further

  17. Operational experience with nanocoulomb bunch charges in the Cornell photoinjector

    Directory of Open Access Journals (Sweden)

    Adam Bartnik

    2015-08-01

    Full Text Available Characterization of 9–9.5 MeV electron beams produced in the dc-gun based Cornell photoinjector is given for bunch charges ranging from 20 pC to 2 nC. Comparison of the measured emittances and longitudinal current profiles to optimized 3D space charge simulations yields excellent agreement for bunch charges up to 1 nC when the measured laser distribution is used to generate initial particle distributions in simulation. Analysis of the scaling of the measured emittance with bunch charge shows that the emittance scales roughly as the square root of the bunch charge up to 300 pC, above which the trend becomes linear. These measurements demonstrate that the Cornell photoinjector can produce cathode emittance dominated beams meeting the emittance and peak current specifications for next generation free electron lasers operating at high repetition rate. In addition, the 1 and 2 nC results are relevant to the electron ion collider community.

  18. WISC-III cognitive profiles in children with developmental dyslexia: specific cognitive disability and diagnostic utility.

    Science.gov (United States)

    Moura, Octávio; Simões, Mário R; Pereira, Marcelino

    2014-02-01

    This study analysed the usefulness of the Wechsler Intelligence Scale for Children-Third Edition in identifying specific cognitive impairments that are linked to developmental dyslexia (DD) and the diagnostic utility of the most common profiles in a sample of 100 Portuguese children (50 dyslexic and 50 normal readers) between the ages of 8 and 12 years. Children with DD exhibited significantly lower scores in the Verbal Comprehension Index (except the Vocabulary subtest), Freedom from Distractibility Index (FDI) and Processing Speed Index subtests, with larger effect sizes than normal readers in Information, Arithmetic and Digit Span. The Verbal-Performance IQs discrepancies, Bannatyne pattern and the presence of FDI; Arithmetic, Coding, Information and Digit Span subtests (ACID) and Symbol Search, Coding, Arithmetic and Digit Span subtests (SCAD) profiles (full or partial) in the lowest subtests revealed a low diagnostic utility. However, the receiver operating characteristic curve and the optimal cut-off score analyses of the composite ACID; FDI and SCAD profiles scores showed moderate accuracy in correctly discriminating dyslexic readers from normal ones. These results suggested that in the context of a comprehensive assessment, the Wechsler Intelligence Scale for Children-Third Edition provides some useful information about the presence of specific cognitive disabilities in DD. Practitioner Points. Children with developmental dyslexia revealed significant deficits in the Wechsler Intelligence Scale for Children-Third Edition subtests that rely on verbal abilities, processing speed and working memory. The composite Arithmetic, Coding, Information and Digit Span subtests (ACID); Freedom from Distractibility Index and Symbol Search, Coding, Arithmetic and Digit Span subtests (SCAD) profile scores showed moderate accuracy in correctly discriminating dyslexics from normal readers. Wechsler Intelligence Scale for Children-Third Edition may provide some useful

  19. The analysis of bunch production in the oil palm

    NARCIS (Netherlands)

    Sparnaaij, L.D.

    1959-01-01

    Bunch yield of oil palms can be expressed as the product of number of bunches and average bunch weight. Number of bunches is itself composite, being determined by number of leaves, percentage floral abortion, sex ratio and percentage bunch failure. Of these elements sex ratio proved to be most

  20. Method for the determination of the three-dimensional structure of ultrashort relativistic electron bunches

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca; Ilinski, Petr; Saldin, Evgeni; Schneidmiller, Evgeni; Yurkov, Mikhail

    2009-05-15

    We describe a novel technique to characterize ultrashort electron bunches in Xray Free-Electron Lasers. Namely, we propose to use coherent Optical Transition Radiation to measure three-dimensional (3D) electron density distributions. Our method relies on the combination of two known diagnostics setups, an Optical Replica Synthesizer (ORS) and an Optical Transition Radiation (OTR) imager. Electron bunches are modulated at optical wavelengths in the ORS setup.When these electron bunches pass through a metal foil target, coherent radiation pulses of tens MW power are generated. It is thereafter possible to exploit advantages of coherent imaging techniques, such as direct imaging, diffractive imaging, Fourier holography and their combinations. The proposed method opens up the possibility of real-time, wavelength-limited, single-shot 3D imaging of an ultrashort electron bunch. (orig.)

  1. Diagnostic and therapeutic approaches in respiratory allergy are different depending on the profile of aeroallergen sensitisation.

    Science.gov (United States)

    Domínguez-Ortega, J; Quirce, S; Delgado, J; Dávila, I; Martí-Guadaño, E; Valero, A

    2014-01-01

    There are few studies which analyse the characteristics of allergic respiratory disease according to profiles of sensitisation to different allergens. This study describes the clinical features and therapeutic approaches, according to the sensitisation profile to relevant aeroallergens, in a sample of adult patients with a first-time diagnosis of respiratory allergy (rhinitis and/or asthma). 1287 patients, enrolled consecutively in the spring of 2010 by 200 allergy specialists, were classified into four groups according to sensitisation to significant allergens in each geographical area (grass pollen, olive pollen, grass and olive pollen, house dust mites). Information was obtained on demographics, diagnostic procedures used, treatments prescribed, clinical characteristics of the rhinitis, and severity and control of asthma. Of the patients, 58.6% had rhinitis only and 38.7% had both rhinitis and asthma. Patients with more severe rhinitis had more severe and poorer controlled asthma. Sensitisation to different allergens was not associated with significant differences in severity and control of asthma, but patients with house dust mite allergy presented persistent rhinitis more frequently. Allergy to grass pollen was significantly associated with food allergies. Differences were observed in the frequency of prescription of immunotherapy and antileukotrienes in patients allergic to house dust mites and of topical corticosteroids in patients with pollen allergy. It was observed in this study that in respiratory allergy disease, there are clinical differences as well as differences in diagnostic procedure and therapeutic attitudes, depending on the clinically relevant allergen. Copyright © 2012 SEICAP. Published by Elsevier Espana. All rights reserved.

  2. Importance of radial profiles in spectroscopic diagnostics applied to the EXTRAP-T2R reversed-field pinch

    OpenAIRE

    Gravestijn, Bob

    2003-01-01

    The determination of the plasma confinement propertiesdemand data as the electron temperature, the ionic and electrondensity profiles and the radiative emissivity profiles. Thefocus of this thesis is the importance of radial profiles inspectroscopic diagnostics applied to the EXTRAP-T2Rreversed-field pinch. EXTRAP-T2R is a resistive shell reversed-field pinch with amagnetic field shell penetration time much longer than therelaxation cycle time scale. Significant improvements inconfinement pro...

  3. Transverse coupled-bunch instabilities for non-symmetric bunch fillings

    CERN Document Server

    Meincke, O

    1998-01-01

    A program has been written in order to investigate transverse coupled-bunch instabilities for non-symmetric bunch fillings in the case of a large number of bunches. After a short description of the method used to find the instability growth rates, first results of the program are discussed for the SPS and LHC. In particular, a systematic study of the effect of fluctuations in the bunch populations is presented.

  4. Modeling two-stage bunch compression with wakefields: Macroscopic properties and microbunching instability

    Directory of Open Access Journals (Sweden)

    R. A. Bosch

    2008-09-01

    Full Text Available In a two-stage compression and acceleration system, where each stage compresses a chirped bunch in a magnetic chicane, wakefields affect high-current bunches. The longitudinal wakes affect the macroscopic energy and current profiles of the compressed bunch and cause microbunching at short wavelengths. For macroscopic wavelengths, impedance formulas and tracking simulations show that the wakefields can be dominated by the resistive impedance of coherent edge radiation. For this case, we calculate the minimum initial bunch length that can be compressed without producing an upright tail in phase space and associated current spike. Formulas are also obtained for the jitter in the bunch arrival time downstream of the compressors that results from the bunch-to-bunch variation of current, energy, and chirp. Microbunching may occur at short wavelengths where the longitudinal space-charge wakes dominate or at longer wavelengths dominated by edge radiation. We model this range of wavelengths with frequency-dependent impedance before and after each stage of compression. The growth of current and energy modulations is described by analytic gain formulas that agree with simulations.

  5. A Practical Illustration of Multidimensional Diagnostic Skills Profiling: Comparing Results from Confirmatory Factor Analysis and Diagnostic Classification Models

    Science.gov (United States)

    Kunina-Habenicht, Olga; Rupp, Andre A.; Wilhelm, Oliver

    2009-01-01

    In recent years there has been an increasing international interest in fine-grained diagnostic inferences on multiple skills for formative purposes. A successful provision of such inferences that support meaningful instructional decision-making requires (a) careful diagnostic assessment design coupled with (b) empirical support for the structure…

  6. Influence of proton bunch and plasma parameters on the AWAKE experiment

    Science.gov (United States)

    Moreira, Mariana; Vieira, Jorge; Muggli, Patric

    2017-10-01

    The Proton Driven Plasma Wakefield Acceleration Experiment (AWAKE) at CERN will test the concept underlying plasma wakefield acceleration using long proton beams that undergo the self-modulation instability. The effectiveness of the experiment hinges on the successful and predictable development of this instability, which fragments the initial proton bunch into smaller beamlets with lengths of the order of the plasma wavelength. Since the initial parameters of the experiment inevitably vary from event to event, this work will aim to understand the correlation between these variations and the resulting wakefield. Using both theoretical models and numerical particle-in-cell simulations, the influence of variations in initial bunch charge, bunch dimensions, bunch energy and plasma density profile on the excited accelerating gradients and on the final energies reached by the witness particles will be investigated. In addition, further options in the experiment setup will be explored with the aim of optimizing the results.

  7. Generation of attosecond electron bunches in a laser-plasma accelerator using a plasma density upramp

    Energy Technology Data Exchange (ETDEWEB)

    Weikum, M.K., E-mail: maria.weikum@desy.de [Deutsches Elektronensynchrotron (DESY), Bdg. 30b, Notkestr. 85, 22607 Hamburg (Germany); Department of Physics, University of Strathclyde, G4 0NG Glasgow (United Kingdom); Li, F.Y. [Department of Physics, University of Strathclyde, G4 0NG Glasgow (United Kingdom); Assmann, R.W. [Deutsches Elektronensynchrotron (DESY), Bdg. 30b, Notkestr. 85, 22607 Hamburg (Germany); Sheng, Z.M. [Department of Physics, University of Strathclyde, G4 0NG Glasgow (United Kingdom); Laboratory for Laser Plasmas and Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240 (China); Jaroszynski, D. [Department of Physics, University of Strathclyde, G4 0NG Glasgow (United Kingdom)

    2016-09-01

    Attosecond electron bunches and attosecond radiation pulses enable the study of ultrafast dynamics of matter in an unprecedented regime. In this paper, the suitability for the experimental realization of a novel scheme producing sub-femtosecond duration electron bunches from laser-wakefield acceleration in plasma with self-injection in a plasma upramp profile has been investigated. While it has previously been predicted that this requires laser power above a few hundred terawatts typically, here we show that the scheme can be extended with reduced driving laser powers down to tens of terawatts, generating accelerated electron pulses with minimum length of around 166 attoseconds and picocoulombs charge. Using particle-in-cell simulations and theoretical models, the evolution of the accelerated electron bunch within the plasma as well as simple scalings of the bunch properties with initial laser and plasma parameters are presented. - Highlights: • LWFA with an upramp density profile can trap and accelerate sub-fs electron beams. • A reduction of the necessary threshold laser intensity by a factor 4 is presented. • Electron properties are tuned by varying initial laser and plasma parameters. • Simulations predict electron bunch lengths below 200 attoseconds with pC charge. • Strong bunch evolution effects and a large energy spread still need to be improved.

  8. Correlation between morphological characters and estimated bunch ...

    African Journals Online (AJOL)

    The methodology of multiple linear regression (MLR) was used to estimate bunch weight. The most significant variables that were measured included number of leaves at harvest, number of fruits per bunch, FW, FL, rachis weight (RW) and stalk length (SL), generating the following prediction equation: BW= -5.249 + ...

  9. Bunch length measurements using synchrotron ligth monitor

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Mahmoud [Old Dominion University, Norfolk, VA; Tiefenback, Michael G. [Jefferson Lab, Newport News, VA

    2015-09-01

    The bunch length is measured at CEBAF using an invasive technique. The technique depends on applying an energy chirp for the electron bunch and imaging it through a dispersive region. The measurements are taken through Arc1 and Arc2 at CEBAF. The fundamental equations, procedure and the latest results are given.

  10. A first analysis of 3-bunches and 1-bunch scenario for the SPL based Proton Driver

    CERN Document Server

    Aiba, M

    2008-01-01

    The SPL based proton driver for a future neutrino factory has been proposed and studied. The use of the SPL proton driver requires an accumulator and an compressor for forming the output time structure required for the neutrino factory. While the number of bunches per burst could be varied in a range of 1-6, it is preferred to be as small as possible for the muon accelerators and storage ring. Thus a scenario of fewer number of bunches is discussed in this note based on the results from the study of 6-bunches scenario. The new scenario enables to have two operation modes, 3-bunches and 1-bunch, using the same accumulator and compressor. Although not everything is covered in this first analysis, the 3-bunches and 1-bunch scenario seems achievable.

  11. Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)

    DEFF Research Database (Denmark)

    Ralfkiaer, Ulrik; Hagedorn, Peter; Bangsgaard, Nannie

    2011-01-01

    Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic resemblance to benign inflammatory skin diseases. To address whether microRNA (miRNA) profiling can discriminate CTCL...... of psoriasis and CTCL. Quantitative (q)RT-PCR analysis of 103 patients with CTCL and benign skin disorders validates differential expression of 4 of the 5 miRNAs and confirms previous reports on miR-155 in CTCL. A qRT-PCR-based classifier consisting of miR-155, miR-203, and miR-205 distinguishes CTCL from...... benign disorders with high specificity and sensitivity, and with a classification accuracy of 95%, indicating that miRNAs have a high diagnostic potential in CTCL....

  12. Properties of Trapped Electron Bunches in a Plasma Wakefield Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, Neil; /SLAC

    2009-10-30

    electron bunches. Chapters four and five present the experimental diagnostics and measurements for the trapped electrons. Next, the sixth chapter introduces suggestions for future trapped electron experiments. Then, Chapter seven contains the conclusions. In addition, there is an appendix chapter that covers a topic which is extraneous to electron trapping, but relevant to the PWFA. This chapter explores the feasibility of one idea for the production of a hollow channel plasma, which if produced could solve some of the remaining issues for a plasma-based collider.

  13. CO{sub 2} laser diagnostics for measurements of the plasma density profile and plasma density fluctuations on LHD

    Energy Technology Data Exchange (ETDEWEB)

    Vyacheslavov, L.N. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation); Tanaka, K.; Kawahata, K. [National Inst. for Fusion Science, Toki, Gifu (Japan)

    2001-04-01

    A CO{sub 2} laser based diagnostics complimentary to the existing FIR interferometer is proposed. It combines interferometry for plasma density profile measurement under conditions of large density gradients, and both imaging and scattering techniques for observation of plasma fluctuations. Two-colour interferometer with a slablike probe beam and a single multichannel linear detector array provide observation of plasma density profile and density fluctuations at two locations along the probe beam. Basic characteristics of the diagnostics are considered as well as some effects that include dispersion and are critical for two colour imaging technique. The results of the bench-top experiments with the prototype of the interferometer are presented. (author)

  14. Measuring the bunch frequency multiplication at the 3rd CLIC Test Facility

    CERN Document Server

    Dabrowski, AE; Bravin, E; Corsini, R; Dobert, S; Lefevre, T; Rabiller, A; Soby, L; Skowronski, P K; Tecker, F; Egger, D; Ferrari, A; Welsch, C P

    2012-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the linac to a final bunch frequency of 12 GHz. To do so, the machine's transverse optics must be tuned to ensure beam isochronicity and each ring's length can finally be adjusted with wiggler magnets to a sub millimeter path length accuracy. Diagnostics based on optical streak camera and RF power measurements, in particular frequency bands, have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents the diagnostics and recent commissioning measurements.

  15. Nonlocal bunching of composite bosons

    Science.gov (United States)

    Lasmar, Zakarya; Kaszlikowski, Dagomir; Kurzyński, Paweł

    2017-09-01

    It was suggested that two entangled fermions can behave like a single boson and that the bosonic quality is proportional to the degree of entanglement between the two particles. The relation between bosonic quality and entanglement is quite natural if one takes into account the fact that entanglement appears in bound states of interacting systems. However, entanglement can still be present in spatially separated subsystems that no longer interact. These systems are often the subject of studies on quantum nonlocality and foundations of quantum physics. Here, we ask whether an entangled spatially separated fermionic pair can exhibit bosonic properties. We show that under certain conditions the answer to this question can be positive. In particular, we propose a nonlocal bunching scenario in which two such pairs form an analog of a two-partite bosonic Fock state.

  16. Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery.

    Science.gov (United States)

    Quek, Camelia; Bellingham, Shayne A; Jung, Chol-Hee; Scicluna, Benjamin J; Shambrook, Mitch C; Sharples, Robyn A; Cheng, Lesley; Hill, Andrew F

    2017-02-01

    Small non-coding RNAs (ncRNA), including microRNAs (miRNA), enclosed in exosomes are being utilised for biomarker discovery in disease. Two common exosome isolation methods involve differential ultracentrifugation or differential ultracentrifugation coupled with Optiprep gradient fractionation. Generally, the incorporation of an Optiprep gradient provides better separation and increased purity of exosomes. The question of whether increased purity of exosomes is required for small ncRNA profiling, particularly in diagnostic and biomarker purposes, has not been addressed and highly debated. Utilizing an established neuronal cell system, we used next-generation sequencing to comprehensively profile ncRNA in cells and exosomes isolated by these 2 isolation methods. By comparing ncRNA content in exosomes from these two methods, we found that exosomes from both isolation methods were enriched with miRNAs and contained a diverse range of rRNA, small nuclear RNA, small nucleolar RNA and piwi-interacting RNA as compared with their cellular counterparts. Additionally, tRNA fragments (30-55 nucleotides in length) were identified in exosomes and may act as potential modulators for repressing protein translation. Overall, the outcome of this study confirms that ultracentrifugation-based method as a feasible approach to identify ncRNA biomarkers in exosomes.

  17. Improving ozone profile retrieval from spaceborne UV backscatter spectrometers using convergence behaviour diagnostics

    Directory of Open Access Journals (Sweden)

    B. Mijling

    2010-11-01

    Full Text Available The Ozone Profile Algorithm (OPERA, developed at KNMI, retrieves the vertical ozone distribution from nadir spectral satellite measurements of back scattered sunlight in the ultraviolet and visible wavelength range. To produce consistent global datasets the algorithm needs to have good global performance, while short computation time facilitates the use of the algorithm in near real time applications.

    To test the global performance of the algorithm we look at the convergence behaviour as diagnostic tool of the ozone profile retrievals from the GOME instrument (on board ERS-2 for February and October 1998. In this way, we uncover different classes of retrieval problems, related to the South Atlantic Anomaly, low cloud fractions over deserts, desert dust outflow over the ocean, and the intertropical convergence zone. The influence of the first guess and the external input data including the ozone cross-sections and the ozone climatologies on the retrieval performance is also investigated. By using a priori ozone profiles which are selected on the expected total ozone column, retrieval problems due to anomalous ozone distributions (such as in the ozone hole can be avoided.

    By applying the algorithm adaptations the convergence statistics improve considerably, not only increasing the number of successful retrievals, but also reducing the average computation time, due to less iteration steps per retrieval. For February 1998, non-convergence was brought down from 10.7% to 2.1%, while the mean number of iteration steps (which dominates the computational time dropped 26% from 5.11 to 3.79.

  18. Temporal characterization of ultrashort linearly chirped electron bunches generated from a laser wakefield accelerator

    Directory of Open Access Journals (Sweden)

    C. J. Zhang

    2016-06-01

    Full Text Available A new method for diagnosing the temporal characteristics of ultrashort electron bunches with linear energy chirp generated from a laser wakefield accelerator is described. When the ionization-injected bunch interacts with the back of the drive laser, it is deflected and stretched along the direction of the electric field of the laser. Upon exiting the plasma, if the bunch goes through a narrow slit in front of the dipole magnet that disperses the electrons in the plane of the laser polarization, it can form a series of bunchlets that have different energies but are separated by half a laser wavelength. Since only the electrons that are undeflected by the laser go through the slit, the energy spectrum of the bunch is modulated. By analyzing the modulated energy spectrum, the shots where the bunch has a linear energy chirp can be recognized. Consequently, the energy chirp and beam current profile of those bunches can be reconstructed. This method is demonstrated through particle-in-cell simulations and experiment.

  19. Radiation excited by a charged-particle bunch on a planar periodic wire structure

    Directory of Open Access Journals (Sweden)

    Andrey V. Tyukhtin

    2014-12-01

    Full Text Available The electromagnetic field of a bunch moving in the presence of a plane grid composed of thin parallel wires is considered by using the averaged boundary conditions method. Two different cases of motion are examined. In the first one, the bunch moves at a constant distance from the grid orthogonally to the wires. The excited surface wave is presented in the form of a spectral integral for a thin bunch with an arbitrary longitudinal profile. The wave propagates along the wires and does not decay with distance (if dissipation is negligible. Energy losses of the bunch over a unit path are obtained. In the second case, the bunch orthogonally crosses the wire grid. The volume and surface waves are separately analyzed. Properties of the spectral angular density of energy of volume radiation in the far-field zone are described. The energy losses due to the volume and surface radiation are determined. It is demonstrated that the structure of the surface waves in both cases allows determination of the length of the bunch.

  20. Quasi-Experimental Study: Head Start Preschoolers' Cognitive Development as Assessed by the Learning Accomplishment Profile--Diagnostic

    Science.gov (United States)

    Hines, Jeanne M.

    2014-01-01

    Abstract Preschoolers' cognitive abilities were assessed each year as part of the Head Start Program requirements. The Head Start PK-4 Center evaluated preschoolers' cognition by administering the Learning Accomplishment Profile-Diagnostic (LAP-D), as a pretest and posttest measure. The LAP-D study used archival data collected from the 2009-2010…

  1. Space Charge Mitigation by Hollow Bunches

    CERN Multimedia

    Oeftiger, AO

    2014-01-01

    To satisfy the requirements of the HL-LHC (High Luminosity Large Hadron Collider), the LHC injector chain will need to supply a higher brightness, i.e. deliver the same transverse beam emittances \\epsilon_{x,y} while providing a higher intensity N. However, a larger number of particles per bunch enhances space charge effects. One approach to mitigate the impact of space charge is to change the longitudinal phase space distribution: hollow bunches feature a depleted bunch centre and a densely populated periphery. Thus, the spatial line density maximum is depressed which ultimately decreases the tune spread imposed by space charge. Therefore, a higher intensity can be accepted while keeping the same overall space charge tune shift. 3 different methods to create hollow bunches in the PSBooster are simulated.

  2. LHC Longitudinal Single-Bunch Stability Threshold

    CERN Document Server

    Esteban Muller, Juan Federico; Baudrenghien, Philippe; Lasheen, Alexandre; Roggen, Toon; Shaposhnikova, Elena; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The aim of the MD studies presented here was to determine with a reasonable accuracy the single-bunch longitudinal stability threshold in the LHC. The measurements were performed by placing along the ring 8 or 20 ‘single’ bunches with different intensities but similar longitudinal emittances. Then they were accelerated and bunch stability was observed at arrival to flat top. Combining the results of two measurement sessions, the single bunch stability threshold is estimated to be (2.4 ± 0.2) × 10^11 ppb for an emittance of 1.89 eVs (1.0 ns) at 6.5 TeV with 12 MV RF voltage. Measurements were taken during the MD session MD472 from 22:00 on 20th to 05:00 on 21st July 2015 and session MD365 from 17:00 on 26th to 01:00 on 27th August 2015.

  3. Structural changes in bunched crystalline ion beams

    CERN Document Server

    Bussmann, M; Schätz, T; Habs, D

    2003-01-01

    Measurements of the spatial distribution of bunched crystalline ion beams in the radio frequency quadrupole storage ring PALLAS are presented for different ratios of the longitudinal and the transverse confinement strengths. The length of highly elongated crystalline ion bunches and its dependence on the bunching voltage is compared to predictions for a one-dimensional ion string and three-dimensional space-charge-dominated beams. The length is found to be considerably shorter than that predicted by the models. Furthermore, the scaling of the length with the bunching voltage is shown to differ from the expected inverse cube root scaling. These differences can partially be attributed to the formation of a mixed crystalline structure. Additionally, a concise mapping of the structural transition from a string to a zig-zag configuration as a function of the ratio of the confinement strengths is presented, which in a similar way deviates from the predictions.

  4. Generation and measurement of velocity bunched ultrashort bunch of pC charge

    Directory of Open Access Journals (Sweden)

    X. H. Lu

    2015-03-01

    Full Text Available In this paper, we discuss the velocity compression in a short rf linac of an electron bunch from a rf photoinjector operated in the blowout regime. Particle tracking simulations shows that with a beam charge of 2 pC an ultrashort bunch duration of 16 fs can be obtained at a tight longitudinal focus downstream of the linac. A simplified coherent transition radiation (CTR spectrum method is developed to enable the measurement of ultrashort (sub-50 fs bunches at low bunch energy (5 MeV and low bunch charges (<10  pC. In this method, the ratio of the radiation energy selected by two narrow bandwidth filters is used to estimate the bunch length. The contribution to the coherent form factor of the large transverse size of the bunch suppresses the radiation signal significantly and is included in the analysis. The experiment was performed at the UCLA Pegasus photoinjector laboratory. The measurement results show bunches of sub-40 fs with 2 pC of charge well consistent with the simulation using actual experimental conditions. These results open the way to the generation of ultrashort bunches with time-duration below 10 fs once some of the limitations of the setup (rf phase jitter, amplitude instability and low field in the gun limited by breakdown are corrected.

  5. Towards Attosecond High-Energy Electron Bunches: Controlling Self-Injection in Laser-Wakefield Accelerators Through Plasma-Density Modulation

    Science.gov (United States)

    Tooley, M. P.; Ersfeld, B.; Yoffe, S. R.; Noble, A.; Brunetti, E.; Sheng, Z. M.; Islam, M. R.; Jaroszynski, D. A.

    2017-07-01

    Self-injection in a laser-plasma wakefield accelerator is usually achieved by increasing the laser intensity until the threshold for injection is exceeded. Alternatively, the velocity of the bubble accelerating structure can be controlled using plasma density ramps, reducing the electron velocity required for injection. We present a model describing self-injection in the short-bunch regime for arbitrary changes in the plasma density. We derive the threshold condition for injection due to a plasma density gradient, which is confirmed using particle-in-cell simulations that demonstrate injection of subfemtosecond bunches. It is shown that the bunch charge, bunch length, and separation of bunches in a bunch train can be controlled by tailoring the plasma density profile.

  6. Longitudinal bunch length measurement of RFQ beam using in-house developed detector system

    Science.gov (United States)

    Pandey, H. K.; Dechoudhury, S.; Bhattacharyya, T. K.; Chakrabarti, A.

    2017-09-01

    We report here the bunch width measurement of 98keV/u ion beam accelerated through a 3.4 m long 37.8 MHz Radio Frequency Quadruple (RFQ) linac using a minimally interceptive approach. The detector system for this measurement has been indigenously developed and is based on secondary electron emission from tungsten filament on being hit by ion beam, followed by a capacitive loaded helical resonator cavity. A Channeltron Electron Multiplier (CEM) detector is used for detection of electrons. The design, development and optimization of various parameters of bunch width detector system along with its deflector cavity applicable in the low frequency regime (few tens of MHz) have been discussed. The measured bunch profile of accelerated Nitrogen beam from RFQ is in close agreement with the estimated profile obtained via simulation.

  7. Review of diagnostics for next generation linear accelerators

    CERN Document Server

    Ross, M

    2001-01-01

    New electron linac designs incorporate substantial advances in critical beam parameters such as beam loading and bunch length and will require new levels of performance in stability and phase space control. In the coming decade, e- (and e+) linacs will be built for a high power linear collider (TESLA, CLIC, JLC/NLC), for fourth generation X-ray sources (TESLA FEL, LCLS, Spring 8 FEL) and for basic accelerator research and development (Orion). Each project assumes significant instrumentation performance advances across a wide front. This review will focus on basic diagnostics for beam position and phase space monitoring. Research and development efforts aimed at high precision multi-bunch beam position monitors, transverse and longitudinal profile monitors and timing systems will be described.

  8. Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.

    Science.gov (United States)

    Byun, J-S; Hong, S-H; Choi, J-K; Jung, J-K; Lee, H-J

    2015-11-01

    Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was designed to examine salivary exosomal microRNAs (miRNAs) that could be candidates for diagnosing and elucidating the pathogenesis of oral lichen planus. We compared miRNA profiles of salivary exosomes of patients with oral lichen planus with those of healthy controls. Saliva samples from 16 patients with oral lichen planus and eight healthy controls were divided into two sets and examined using miRNA microarray analysis and TaqMan quantitative PCR. The three miRNAs identified (miR-4484, miR-1246, and miR-1290) were further validated. Of these, miR-4484 was significantly upregulated in the salivary exosomes of patients with oral lichen planus. This study thus identifies a potential miRNA biomarker for oral lichen planus and provides insight into the functions of miRNAs in the pathogenesis of oral inflammatory diseases. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer.

    Science.gov (United States)

    Ali, S; Saleh, H; Sethi, S; Sarkar, F H; Philip, P A

    2012-10-09

    A major challenge to the development of biomarkers for pancreatic cancer (PC) is the small amount of tissue obtained at the time of diagnosis. Single-gene analyses may not reliably predict biology of PC because of its complex molecular makeup. MicroRNA (miRNA) profiling may provide a more informative molecular interrogation of tumours. The primary objective of this study was to determine the feasibility of performing miRNA arrays and quantitative real-time PCR (qRT-PCR) from archival formalin-fixed paraffin-embedded (FFPE) cell blocks obtained from fine-needle aspirates (FNAs) that is the commonest diagnostic procedure for suspected PC. MicroRNA expression profiling was performed on FFPE from FNA of suspicious pancreatic masses. Subjects included those who had a pathological diagnosis of pancreatic adenocarcinoma and others with a non-malignant pancreatic histology. Exiqon assay was used to quantify miRNA levels and qRT-PCR was used to validate abnormal expression of selected miRNAs. A total of 29 and 15 subjects had pancreatic adenocarcinoma and no evidence of cancer, respectively. The RNA yields per patient varied from 25 to 100 ng. Profiling demonstrated deregulation of over 228 miRNAs in pancreatic adenocarcinoma of which the top 7 were further validated by qRT-PCR. The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients. MicroRNAs let-7d and miR-423-5p was either downregulated or upregulated with a significant inter-individual variation in their expression. This study demonstrated the feasibility of using archival FFPE cell blocks from FNAs to establish RNA-based molecular signatures unique to pancreatic adenocarcinoma with potential applications in clinical trials for risk stratification, patient selection, and target validation.

  10. How Do Young Students with Different Profiles of Reading Skill Mastery, Perceived Ability, and Goal Orientation Respond to Holistic Diagnostic Feedback?

    Science.gov (United States)

    Jang, Eunice Eunhee; Dunlop, Maggie; Park, Gina; van der Boom, Edith H.

    2015-01-01

    One critical issue with cognitive diagnostic assessment (CDA) lies in its lack of research evidence that shows how diagnostic feedback from CDA is interpreted and used by young students. This mixed methods research examined how holistic diagnostic feedback (HDF) is processed by young learners with different profiles of reading skills, goal…

  11. Measurements of Transverse Coupled-Bunch Instabilities in PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, D.

    2005-04-11

    At the design currents the PEP-II High and Low Energy Rings operate above the coupled-bunch instability thresholds in horizontal and vertical planes. Both machines have used analog bunch-by-bunch feedback systems to stabilize the beams since commissioning. Here we present a measurement technique that uses the capabilities of the PEP-II programmable digital longitudinal feedback system to provide transient diagnostics in X or Y directions. This technique allows one to measure instability growth or damping rates as well as oscillation frequencies in both open-loop and closed-loop conditions. Based on these measurements the configuration of the relevant transverse feedback channel can be optimized. The technique will be illustrated with instability measurements and feedback optimization examples. Comparisons of the measured modal patterns and growth rates to the theoretical predictions will be presented.

  12. Transition radiation from graphene plasmons by a bunch beam in the terahertz regime.

    Science.gov (United States)

    Zhang, Kai-Chun; Chen, Xiao-Xing; Sheng, Chang-Jian; Ooi, Kelvin J A; Ang, Lay Kee; Yuan, Xue-Song

    2017-08-21

    The terahertz band is an increasingly important spectrum in a wide range of applications from bioimaging and medical diagnostics to security and wireless communications. We propose a tunable terahertz coherent radiation source based on graphene plasmon-induced transition radiation. The transition radiation in terahertz regime arises from the graphene plasmons, which are excited by a normally incident bunched electron beam. We analyze the field-intensities and spectral-angular distributions of the transition radiation with respect to Fermi energy, substrate dielectric permittivity, and electron bunch energy for both the coherent and incoherent radiation. The effect of electron bunching on the radiation pattern is discussed. The mechanism of plasmon frequency-selective transition radiation is discovered.

  13. Extremely short relativistic-electron-bunch generation in the laser wakefield via novel bunch injection scheme

    NARCIS (Netherlands)

    Khachatryan, A.G.; van Goor, F.A.; Boller, Klaus J.; Reitsma, A.J.W.; Jaroszynski, D.A.

    2004-01-01

    Recently a new electron-bunch injection scheme for the laser wakefield accelerator has been proposed [JETP Lett. 74, 371 (2001); Phys. Rev. E 65, 046504 (2002)]. In this scheme, a low energy electron bunch, sent in a plasma channel just before a high-intensity laser pulse, is trapped in the laser

  14. Curvature-Induced Bunch Self-Interaction for an Energy-Chirped Bunch in Magnetic Bends

    Energy Technology Data Exchange (ETDEWEB)

    Rui Li

    2006-01-04

    The curvature-induced bunch collective interaction in magnetic bends can be studied using effective forces in the canonical formulation of the coherent synchrotron radiation (CSR) effect. In this paper, for an electron distribution moving ultrarelativistically in a bending system, the dynamics of a particle in the electron distribution is derived from the Hamiltonian of the particle in terms of the bunch internal coordinates. The consequent Vlasov equation manifests explicitly how the phase space distribution is perturbed by the effective CSR forces. In particular, we study the impact of an initial linear energy chirp of the bunch on the behavior of the effective longitudinal CSR force, which arises due to the modification of the retardation relation as a result of the energy-chirping-induced longitudinal-horizontal correlation of the bunch distribution (bunch tilt) in dispersive regions.

  15. Real-Time, Single-Shot Temporal Measurements of Short Electron Bunches, Terahertz CSR and FEL Radiation

    CERN Document Server

    Berden, G; Van der Meer, A F G

    2005-01-01

    Electro-optic detection of the Coulomb field of electron bunches is a promising technique for single-shot measurements of the bunch length and shape in the sub-picosecond time domain. This technique has been applied to the measurement of 50 MeV electron bunches in the FELIX free electron laser, showing the longitudinal profile of single bunches of around 650 fs FWHM [Phys. Rev. Lett. 93, 114802 (2004)]. The method is non-destructive and real-time, and therefore ideal for online monitoring of the longitudinal shape of single electron bunches. At FELIX we have used it for real-time optimization of sub-picosecond electron bunches. Electro-optic detection has also been used to measure the electric field profiles of far-infrared (or terahertz) optical pulses generated by the relativistic electrons. We have characterised the far-infrared output of the free electron laser, and more recently, we have measured the temporal profile of terahertz optical pulses generated at one of the bending magnets.

  16. Characterizing a Hidden Group of At-Risk Drinkers: Epidemiological Profiles of Alcohol-Use Disorder Diagnostic Orphans.

    Science.gov (United States)

    Gilbert, Paul A; Marzell, Miesha

    2017-11-29

    Drinkers who report some symptoms of alcohol-use disorder (AUD) but fail to meet full criteria are "diagnostic orphans." To improve risk-reduction efforts, we sought to develop better epidemiologic profiles of this underrecognized subgroup. This study estimated the population prevalence and described AUD symptoms of diagnostic orphans using the 2012-2013 National Epidemiological Survey of Alcohol and Related Conditions-III. Multivariate logistic regression was used to model odds of being a diagnostic orphan or meeting mild, moderate, and severe AUD criteria versus no AUD symptoms. Models were adjusted for the complex survey design using sampling weights and survey procedures (e.g., proc surveylogistic). Among drinkers, 14% of men and 11% of women were classified as diagnostic orphans. The most common symptoms were drinking more or for longer periods than intended, wanting or trying unsuccessfully to quit or cut back, and drinking in ways that increased risk of injury. We noted broad similarities between diagnostic orphans and mild/moderate AUD groups. There were no differences in odds of diagnostic orphans status by race/ethnicity; however, female gender was associated with lower odds of diagnostic orphan status and all levels of AUD. Individual history of AUD, family history of problem drinking, concurrent smoking, and concurrent marijuana use were associated with greater odds of problem drinking, with stronger associations as AUD severity increased. Diagnostic orphans remain a sizeable and overlooked population of problem drinkers. Clarifying the array of symptoms and cooccurring disorders can improve screening and facilitate alcohol risk-reduction intervention efforts.

  17. Loss of Landau Damping for Bunch Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Burov, A.; /Fermilab

    2011-04-11

    Conditions for the existence, uniqueness and stability of self-consistent bunch steady states are considered. For the existence and uniqueness problems, simple algebraic criteria are derived for both the action and Hamiltonian domain distributions. For the stability problem, van Kampen theory is used. The onset of a discrete van Kampen mode means the emergence of a coherent mode without any Landau damping; thus, even a tiny couple-bunch or multi-turn wake is sufficient to drive the instability. The method presented here assumes an arbitrary impedance, RF shape, and beam distribution function. Available areas on the intensity-emittance plane are shown for resistive wall wake and single harmonic, bunch shortening and bunch lengthening RF configurations. Thresholds calculated for the Tevatron parameters and impedance model are in agreement with the observations. These thresholds are found to be extremely sensitive to the small-argument behaviour of the bunch distribution function. Accordingly, a method to increase the LLD threshold is suggested. This article summarizes and extends recent author's publications.

  18. Microwave measurement of intra bunch charge distributions

    CERN Document Server

    Dehler, M

    2003-01-01

    A direct way of obtaining intra bunch charge distributions is to measure the amplitude roll off as well as the phase behavior of the spectrum of the single bunch self field. To that effect, a microwave pickup together with a microwave front end has been installed in the storage ring of the Swiss Light Source (SLS). As pickup, button type bpms are used, which have been designed for a broad band behavior in the excess of 30 GHz. Three bpms together with their individual front ends are used in order to sample the beam spectrum at frequencies of 6, 12 and 18 GHz, which compares to the standard spectrum of a 1 mA single bunch extending to approximately 12 GHz (13 ps rms bunch length). The signals are mixed to base band in loco using the multiplied RF frequency as a LO. By shifting the LO phase, simultaneously the amplitude roll off as well the complex phase of the beam spectrum can be obtained. Where using a resonator as a pickup would smear out the response over several bunches, allowing only the determination of...

  19. Autoantibody profiling of benign and malignant thyroid tumors and design of a prototype diagnostic array

    OpenAIRE

    K V Lanshchakov; P V Belousov; V E Vanushko; A Yu Abrosimov; D V Kuprash; N S Kuznetsov

    2012-01-01

    Currently the “gold standard” in diagnostics of thyroid tumors is a fine-needle aspiration cytology (FNAC). However, FNAC cannot discriminate between benign and malignant thyroid tumors in 15 to 30% of observations. In order to develop an additional tool for differential diagnostics of thyroid tumors we evaluated the diagnostic performance of 3-antigen serum autoantibody signature in groups of benign ( n = 22) and malignant ( n = 26) thyroid tumors using a dot-blot ELISA-based analysis The se...

  20. Optical replica based longitudinal diagnostic for CLIC

    CERN Document Server

    Angelova-Hamberg, G

    2008-01-01

    The performance of the CLIC main linac critically depends on the beam properties at its entrance. We discuss a method, based on practical experience gathered in the optical replica experiment in FLASH at DESY, that allows to diagnose longitudinal properties of individual bunches within a bunch train at several places in the transfer line between the damping ring and the main linac. Apart from the possibility to obtain single-shot non-invasive longitudinal bunch profiles this method allows to analyze the longitudinal-transverse correlations (beam-tails) within a bunch.

  1. Beam Diagnostics of the Small Isochronous Ring

    Energy Technology Data Exchange (ETDEWEB)

    Felix Marti; Eduard Pozdeyev

    2004-07-01

    The purpose of this paper is to describe the beam diagnostic systems in the Small Isochronous Ring (SIR) developed and built at the National Superconducting Cyclotron Laboratory (NSCL) at Michigan State University (MSU). SIR is a small-scale experiment that simulates the dynamics of intense beams in large accelerators. A 20 to 30 keV hydrogen or deuterium ion bunch is injected in the ring, extracted after a variable number of turns and its longitudinal profile is studied. Some of the diagnostic tools available in SIR include an emittance measurement system in the injection line, scanning wires in different sections of the ring, phosphor screens at the injection and extraction points and a fast Faraday cup in the extraction line. The design of these systems and the kind of beam information they provide are discussed in detail.

  2. Bunching transition in a time-headway model of a bus route.

    Science.gov (United States)

    Nagatani, T

    2001-03-01

    A time-headway model is presented to mimic bus behavior on the bus route. The motion of a bus is described in terms of the time headway between its bus and the bus in front. We study the bunching behavior of buses induced by interacting with other buses and passengers. It is shown that the dynamical phase transitions among the inhomogeneous bunching phase, the homogeneous free phase, the coexisting phase, and the homogeneous congested phase occur with varying the initial time headway. We study the effect of not stopping at bus stops on the time-headway profile. It is found that the bunching transition lines are consistent with the neutral stability curves obtained by the linear stability analysis.

  3. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF gene as a potent diagnostic biomarker in major depression.

    Directory of Open Access Journals (Sweden)

    Manabu Fuchikami

    Full Text Available Major depression, because of its recurring and life-threatening nature, is one of the top 10 diseases for global disease burden. Major depression is still diagnosed on the basis of clinical symptoms in patients. The search for specific biological markers is of great importance to advance the method of diagnosis for depression. We examined the methylation profile of 2 CpG islands (I and IV at the promoters of the brain-derived neurotrophic factor (BDNF gene, which is well known to be involved in the pathophysiology of depression. We analyzed genomic DNA from peripheral blood of 20 Japanese patients with major depression and 18 healthy controls to identify an appropriate epigenetic biomarker to aid in the establishment of an objective system for the diagnosis of depression. Methylation rates at each CpG unit was measured using a MassArray® system (SEQUENOM, and 2-dimensional hierarchical clustering analyses were undertaken to determine the validity of these methylation profiles as a diagnostic biomarker. Analyses of the dendrogram from methylation profiles of CpG I, but not IV, demonstrated that classification of healthy controls and patients at the first branch completely matched the clinical diagnosis. Despite the small number of subjects, our results indicate that classification based on the DNA methylation profiles of CpG I of the BDNF gene may be a valuable diagnostic biomarker for major depression.

  4. Bunch-by-bunch measurement of transverse coherent beam-beam modes in the Fermilab Tevatron collider

    Directory of Open Access Journals (Sweden)

    Giulio Stancari

    2012-04-01

    Full Text Available A system for bunch-by-bunch detection of transverse proton and antiproton coherent oscillations in the Tevatron is described. It is based on the signal from a single beam-position monitor located in a region of the ring with large amplitude functions. The signal is digitized over a large number of turns and Fourier analyzed off-line with a dedicated algorithm. To enhance the signal, band-limited noise is applied to the beam for about 1 s. This excitation does not adversely affect the circulating beams even at high luminosities. The device has a response time of a few seconds, a frequency resolution of 1.6×10^{-5} in fractional tune, and it is sensitive to oscillation amplitudes of 60 nm. It complements Schottky detectors as a diagnostic tool for tunes, tune spreads, and beam-beam effects. Measurements of coherent mode spectra are presented to show the effects of betatron tunes, beam-beam parameter, and collision pattern, and to provide an experimental basis for beam-beam numerical codes. Comparisons with a simplified model of beam-beam oscillations are also described.

  5. Luminosity geometric reduction factor from colliding bunches with different lengths

    Energy Technology Data Exchange (ETDEWEB)

    Verdu-Andres, S. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-09-29

    In the interaction point of the future electron-Ion collider eRHIC, the electron beam bunches are at least one order of magnitude shorter than the proton beam bunches. With the introduction of a crossing angle, the actual number of collisions resulting from the bunch collision gets reduced. Here we derive the expression for the luminosity geometric reduction factor when the bunches of the two incoming beams are not equal.

  6. Autoantibody profiling of benign and malignant thyroid tumors and design of a prototype diagnostic array

    Directory of Open Access Journals (Sweden)

    K V Lanshchakov

    2012-06-01

    Full Text Available Currently the “gold standard” in diagnostics of thyroid tumors is a fine-needle aspiration cytology (FNAC. However, FNAC cannot discriminate between benign and malignant thyroid tumors in 15 to 30% of observations. In order to develop an additional tool for differential diagnostics of thyroid tumors we evaluated the diagnostic performance of 3-antigen serum autoantibody signature in groups of benign ( n = 22 and malignant ( n = 26 thyroid tumors using a dot-blot ELISA-based analysis The sensitivity and specificity of resultant array were estimated to be 55–60% and 95–100%, respectively ( p < 0.001 according to one-sided Fisher Exact Test. Thus, we created a prototype antigen array for differential diagnostics of thyroid tumors which can be regarded as a platform for design of more complicated panel, highly sensitive in thyroid cancer detection, which can significantly improve the accuracy of preoperative diagnosis of thyroid cancer.

  7. Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer

    National Research Council Canada - National Science Library

    Mathé, Ewy A; Patterson, Andrew D; Haznadar, Majda; Manna, Soumen K; Krausz, Kristopher W; Bowman, Elise D; Shields, Peter G; Idle, Jeffrey R; Smith, Philip B; Anami, Katsuhiro; Kazandjian, Dickran G; Hatzakis, Emmanuel; Gonzalez, Frank J; Harris, Curtis C

    2014-01-01

    Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide treatment decisions. Small molecules (<1,500 Da...

  8. Generating ultrarelativistic attosecond electron bunches with laser wakefield accelerators

    NARCIS (Netherlands)

    Luttikhof, M.J.H.; Khachatryan, A.G.; van Goor, F.A.; Boller, Klaus J.

    2010-01-01

    Femtosecond electron bunches with ultrarelativistic energies were recently generated by laser wakefield accelerators. Here we predict that laser wakefield acceleration can generate even attosecond bunches, due to a strong chirp of the betatron frequency. We show how the bunch duration scales with

  9. Electron bunch injection at an angle into a laser wakefield

    NARCIS (Netherlands)

    Luttikhof, M.J.H.; Khachatryan, A.G.; van Goor, F.A.; Boller, Klaus J.; Mora, P.

    2009-01-01

    External injection of electron bunches longer than the plasma wavelength in a laser wakefield accelerator can lead to the generation of femtosecond ultra relativistic bunches with a couple of percent energy spread. Extensive study has been done on external electron bunch (e.g., one generated by a

  10. Interaction of ultrarelativistic electron and proton bunches with dense plasmas

    CERN Document Server

    Rukhadze, A A

    2012-01-01

    Here we discuss the possibility of employment of ultrarelativistic electron and proton bunches for generation of high plasma wakefields in dense plasmas due to the Cherenkov resonance plasma-bunch interaction. We estimate the maximum amplitude of such a wake and minimum system length at which the maximum amplitude can be generated at the given bunch parameters.

  11. Correlation between morphological characters and estimated bunch ...

    African Journals Online (AJOL)

    CHARLES

    2012-06-12

    Jun 12, 2012 ... The objective of this study was to measure and identify the variables that have more influence on bunch weight (BW), and determine a statistical model for predicting yield for the Tropical banana cultivar (cv.). The experiment consisted of a uniformity trial, conducted in Guanambi, Bahia, with a total.

  12. An improved injector bunching geometry for ATLAS

    Indian Academy of Sciences (India)

    Abstract. The bunching system of the ATLAS positive ion injector (PII) has been improved by relocating the harmonic buncher to a point significantly closer to the second stage sine-wave buncher and the injector LINAC. The longitudinal optics design has also been modified and now employs a virtual waist from the ...

  13. An improved injector bunching geometry for ATLAS

    Indian Academy of Sciences (India)

    The bunching system of the ATLAS positive ion injector (PII) has been improved by relocating the harmonic buncher to a point significantly closer to the second stage sine-wave buncher and the injector LINAC. The longitudinal optics design has also been modified and now employs a virtual waist from the harmonic buncher ...

  14. Dancing bunches as Van Kampen modes

    Energy Technology Data Exchange (ETDEWEB)

    Burov, A.; /Fermilab

    2011-03-01

    Van Kampen modes are eigen-modes of Jeans-Vlasov equation [1-3]. Their spectrum consists of continuous and, possibly, discrete parts. Onset of a discrete van Kampen mode means emergence of a coherent mode without any Landau damping; thus, even a tiny couple-bunch wake is sufficient to drive instability. Longitudinal instabilities observed at Tevatron [4], RHIC [5] and SPS [6] can be explained as loss of Landau damping (LLD), which is shown here to happen at fairly low impedances. For repulsive wakes and single-harmonic RF, LLD is found to be extremely sensitive to steepness of the bunch distribution function at small amplitudes. Based on that, a method of beam stabilization is suggested. Emergence of a discrete van Kampen mode means either loss of Landau damping or instability. Longitudinal bunch stability is analysed in weak head-tail approximation for inductive impedance and single-harmonic RF. The LLD threshold intensities are found to be rather low: for cases under study all of them do not exceed a few percent of the zero-amplitude incoherent synchrotron frequency shift, strongly decreasing for shorter bunches. Because of that, LLD can explain longitudinal instabilities happened at fairly low impedances at Tevatron [4], and possibly for RHIC [5] and SPS [6], being in that sense an alternative to the soliton explanation [5, 20]. Although LLD itself results in many cases in emergence of a mode with zero growth rate, any couple-bunch (and sometimes multi-turn) wake would drive instability for that mode, however small this wake is. LLD is similar to a loss of immune system of a living cell, when any microbe becomes fatal for it. The emerging discrete mode is normally very different from the rigid-bunch motion; thus the rigid-mode model significantly overestimates the LLD threshold. The power low of LLD predicted in Ref. [17] agrees with results of this paper. However, the numerical factor in that scaling low strongly depends on the bunch distribution function

  15. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

    Science.gov (United States)

    Khan, Javed; Wei, Jun S.; Ringnér, Markus; Saal, Lao H.; Ladanyi, Marc; Westermann, Frank; Berthold, Frank; Schwab, Manfred; Antonescu, Cristina R.; Peterson, Carsten; Meltzer, Paul S.

    2005-01-01

    The purpose of this study was to develop a method of classifying cancers to specific diagnostic categories based on their gene expression signatures using artificial neural networks (ANNs). We trained the ANNs using the small, round blue-cell tumors (SRBCTs) as a model. These cancers belong to four distinct diagnostic categories and often present diagnostic dilemmas in clinical practice. The ANNs correctly classified all samples and identified the genes most relevant to the classification. Expression of several of these genes has been reported in SRBCTs, but most have not been associated with these cancers. To test the ability of the trained ANN models to recognize SRBCTs, we analyzed additional blinded samples that were not previously used for the training procedure, and correctly classified them in all cases. This study demonstrates the potential applications of these methods for tumor diagnosis and the identification of candidate targets for therapy. PMID:11385503

  16. Magnetic diagnostics: general principles and the problem of reconstruction of plasma current and pressure profiles in toroidal systems

    Energy Technology Data Exchange (ETDEWEB)

    Pustovitov, V.D.

    2000-04-01

    The restrictions of the magnetic diagnostics are discussed. Being related to the integral nature of the measurable quantities, they follow from the fundamental laws of electromagnetism. A series of particular examples demonstrating the strength of these restrictions is given and analyzed. A general rule is emphasized that the information obtained from external magnetic measurements is obviously insufficient for the reliable evaluation of plasma current and pressure profiles in tokamaks or in stellarators. The underlying reason is that outside the plasma the own field of the equilibrium plasma currents is determined by the boundary conditions on the plasma surface only. (author)

  17. Femtosecond electron-bunch dynamics in laser wakefields and vacuum

    Directory of Open Access Journals (Sweden)

    A. G. Khachatryan

    2007-12-01

    Full Text Available Recent advances in laser wakefield acceleration demonstrated the generation of extremely short (with a duration of a few femtoseconds relativistic electron bunches with relatively low (of the order of couple of percent energy spread. In this article we study the dynamics of such bunches in drift space (vacuum and in channel-guided laser wakefields. Analytical solutions were found for the transverse coordinate of an electron and for the bunch envelope in the wakefield in the case of arbitrary change in the energy. Our results show strong bunch dynamics already on a millimeter scale propagation distance both in plasma and in vacuum. When the bunch propagates in vacuum, its transverse sizes grow considerably; the same is observed for the normalized bunch emittance that worsens the focusability of the bunch. A scheme of two-stage laser wakefield accelerator with small drift space between the stages is proposed. It is found that fast longitudinal betatron phase mixing occurs in a femtosecond bunch when it propagates along the wakefield axis. When bunch propagates off axis, strong bunch decoherence and fast emittance degradation due to the finite bunch length was observed.

  18. Confirmation among College Women: The Eating Disorders Not Otherwise Specified Diagnostic Profile

    Science.gov (United States)

    Schwitzer, Alan; Hatfield, Tammy; Jones, Angela R.; Duggan, Molly H.; Jurgens, Jill; Winninger, Ali

    2008-01-01

    Previously, the researchers proposed and tested a diagnostic framework for women with eating-related concerns who seek college health and mental health treatment. The framework emphasized moderate problems characterized by frequent binging, occasional purging, and frequent exercise; rumination; body image and self-esteem concerns; ambivalence…

  19. Complex soliton bunching patterns induced by nonsaturable absorption

    Science.gov (United States)

    Chen, Weicheng; Luo, Aiping

    2017-10-01

    A fiber laser with a semiconductor saturable absorption mirror (SESAM) and a graphene-polymer composite (GPC) film is constructed for achieving different soliton bunching patterns. The SESAM is used as a mode locker for self-started pulse generation, while the GPC provides a nonsaturable absorption effect for achieving a bunching in the laser cavity. There are three extra temporal patterns observed in the experiments through adjusting polarization controllers. They are chaotic bunching, weak coherent bunching and modulated harmonic bunching. The experimental investigation shows that dynamic nonsaturable absorption effect of an absorber is beneficial for generating different bunching patterns. Our work can have a deeper understanding of the formation of the complex soliton bunching patterns in pulsed lasers.

  20. Single-shot electron bunch length measurements using a spatial electro-optical autocorrelation interferometer.

    Science.gov (United States)

    Sütterlin, Daniel; Erni, Daniel; Schlott, Volker; Sigg, Hans; Jäckel, Heinz; Murk, Axel

    2010-10-01

    A spatial, electro-optical autocorrelation (EOA) interferometer using the vertically polarized lobes of coherent transition radiation (CTR) has been developed as a single-shot electron bunch length monitor at an optical beam port downstream the 100 MeV preinjector LINAC of the Swiss Light Source. This EOA monitor combines the advantages of step-scan interferometers (high temporal resolution) [D. Mihalcea et al., Phys. Rev. ST Accel. Beams 9, 082801 (2006) and T. Takahashi and K. Takami, Infrared Phys. Technol. 51, 363 (2008)] and terahertz-gating technologies [U. Schmidhammer et al., Appl. Phys. B: Lasers Opt. 94, 95 (2009) and B. Steffen et al., Phys. Rev. ST Accel. Beams 12, 032802 (2009)] (fast response), providing the possibility to tune the accelerator with an online bunch length diagnostics. While a proof of principle of the spatial interferometer was achieved by step-scan measurements with far-infrared detectors, the single-shot capability of the monitor has been demonstrated by electro-optical correlation of the spatial CTR interference pattern with fairly long (500 ps) neodymium-doped yttrium aluminum garnet (Nd:YAG) laser pulses in a ZnTe crystal. In single-shot operation, variations of the bunch length between 1.5 and 4 ps due to different phase settings of the LINAC bunching cavities have been measured with subpicosecond time resolution.

  1. The Beam Instrumentation and Diagnostic Challenges for LHC Operation at high Energy

    CERN Document Server

    Jones, OR

    2014-01-01

    This contribution will present the role of beam diagnostics in facing the challenges posed by running the LHC close to its design energy of 7TeV. Machine protection will be ever more critical, with the quench level of the magnets significantly reduced, so relying heavily on the beam loss system, abort gap monitor, interlocks on the beam position and fast beam current change system. Non-invasive profile monitoring also becomes more of a challenge, with standard synchrotron light imaging limited by diffraction and rest gas ionization monitoring dominated by space charge effects. There is also a requirement to better understand beam instabilities, of which several were observed during Run I, leading to the need for synchronised bunch-by-bunch, turn-by-turn information from many distributed instrumentation systems. All of these challenges will be discussed along with the strategies adopted to overcome them.

  2. Observation of Bunching of Two Bell States

    Science.gov (United States)

    Eisenberg, H. S.; Hodelin, J. F.; Khoury, G.; Bouwmeester, D.

    2006-04-01

    The bunching of two single photons on a beam splitter is a fundamental quantum effect, first observed by Hong, Ou, and Mandel. It is a unique interference effect that relies only on the photons’ indistinguishability and not on their relative phase. We generalize this effect by demonstrating the bunching of two Bell states, created in two passes of a nonlinear crystal, each composed of two photons. When the two Bell states are indistinguishable, phase-insensitive destructive interference prevents the outcome of fourfold coincidence between the four spatial-polarization modes. For certain combinations of the two Bell states, we demonstrate the opposite effect of antibunching. We relate this result to the number of distinguishable modes in parametric down-conversion.

  3. Single-bunch beams for BC-75

    Energy Technology Data Exchange (ETDEWEB)

    Sodja, J.; Clendenin, J.E.; Erickson, R.A.; Miller, R.H.

    1983-06-01

    On June 8, 1983, a beam consisting of a single S-band bunch was transported through the linac into the beam switchyard (BSY) and analyzed in the C-line (Beamline 27) at 30 GeV. The C-line toroid 2712 measured an intensity of approximately 2 x 10/sup 9/e/sup -//pulse. The exact intensity was uncertain due to the limited response time of the toroid for fast, single-bunch beams. However, the linear Q intensity monitors (Lin Q) showed the transmission of the beam through the linac between Sectors 2 and 30 to be fairly flat with an intensity of 3 x 10/sup 9/e/sup -//pulse in the final 19 sectors. The CID Faraday cup, which is located adjacent to the Gun Lin Q, was used to check the calibration of the Lin Q.

  4. USXR Based MHD, Transport, Equilibria and Current Profile Diagnostics for NSTX. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Finkenthal, Michael

    2009-06-01

    The present report resumes the research activities of the Plasma Spectroscopy/Diagnostics Group at Johns Hopkins University performed on the NSTX tokamak at PPPL during the period 1999-2009. During this period we have designed and implemented XUV based diagnostics for a large number of tasks: study of impurity content and particle transport, MHD activity, time-resolved electron temperature measeurements, ELM research, etc. Both line emission and continuum were used in the XUV range. New technics and novel methods have been devised within the framework of the present research. Graduate and post-graduate students have been involved at all times in addition to the senior research personnel. Several tens of papers have been published and lectures have been given based on the obtained results at conferences and various research institutions (lists of these activities were attached both in each proposal and in the annual reports submitted to our supervisors at OFES).

  5. Serum protein profiling by solid phase extraction and mass spectrometry: A future diagnostics tool?

    DEFF Research Database (Denmark)

    Callesen, Anne K; Madsen, Jonna S; Vach, Werner

    2009-01-01

    Serum protein profiling by MS is a promising method for early detection of disease. Important characteristics for serum protein profiling are preanalytical factors, analytical reproducibility and high throughput. Problems related to preanalytical factors can be overcome by using standardized...... and rigorous sample collection and sample handling protocols. The sensitivity of the MS analysis relies on the quality of the sample; consequently, the blood sample preparation step is crucial to obtain pure and concentrated samples and enrichment of the proteins and peptides of interest. This review focuses...... on the serum sample preparation step prior to protein profiling by MALDI MS analysis, with particular focus on various SPE methods. The application of SPE techniques with different chromatographic properties such as RP, ion exchange, or affinity binding to isolate specific subsets of molecules (subproteomes...

  6. Bacillus 'next generation' diagnostics: Moving from detection towards sub-typing and risk related strain profiling

    Directory of Open Access Journals (Sweden)

    Monika eEhling-Schulz

    2013-02-01

    Full Text Available The highly heterogeneous genus Bacillus comprises the largest species group of endospore forming bacteria. Because of their ubiquitous nature, Bacillus spores can enter food production at several stages resulting in significant economic losses and posing a potential risk to consumers due the capacity of certain Bacillus strains for toxin production. In the past, food microbiological diagnostics was focused on the determination of species using conventional culture based methods, which are still widely used. However, due to the extreme intraspecies diversity found in the genus Bacillus, DNA based identification and typing methods are gaining increasing importance in routine diagnostics. Several studies showed that certain characteristics are rather strain dependent than species specific. Therefore, the challenge for current and future Bacillus diagnostics is not only the efficient and accurate identification on species level but also the development of rapid methods to identify strains with specific characteristics (such as stress resistance or spoilage potential, trace contamination sources, and last but not least discriminate potential hazardous strains from non-toxic strains.

  7. Transverse C-band deflecting structure for longitudinal electron-bunch-diagnosis in XFEL “SACLA”

    Energy Technology Data Exchange (ETDEWEB)

    Ego, H., E-mail: ego@spring8.or.jp [Japan Synchrotron Radiation Research Institute (JASRI), Kouto, Sayo, Hyogo (Japan); Maesaka, H.; Sakurai, T.; Otake, Y. [RIKEN SPring-8 Center, Kouto, Sayo, Hyogo (Japan); Hashirano, T.; Miura, S. [Mitsubishi Heavy Industries, Ltd. (MHI), Itozaki, Mihara, Hiroshima (Japan)

    2015-09-21

    In the 8 GeV compact X-ray FEL “SACLA,” a single bunch of electrons is compressed to a duration of approximately 30 fs to yield a peak current of 3 kA, which creates brilliant self-amplified spontaneous emission. To measure the longitudinal profile of an ultrashort electron bunch and verify the compression, we developed a high-gradient C-band RF deflecting structure 1.8 m long and periodically loaded with racetrack-shaped irises. The irises generated a high deflection gradient for the vertically deflecting HEM11-5π/6 dipole mode and suppressed rotation of the deflection plane. The two structures were fabricated and generated a stable total deflecting voltage exceeding 60 MV and revealed the longitudinal electron-bunch profile with an effective time resolution of approximately 10 fs.

  8. Extremely short relativistic-electron-bunch generation in the laser wakefield via novel bunch injection scheme

    Directory of Open Access Journals (Sweden)

    A. G. Khachatryan

    2004-12-01

    Full Text Available Recently a new electron-bunch injection scheme for the laser wakefield accelerator has been proposed [JETP Lett. 74, 371 (2001JTPLA20021-364010.1134/1.1427124; Phys. Rev. E 65, 046504 (2002PLEEE81063-651X10.1103/PhysRevE.65.046504]. In this scheme, a low energy electron bunch, sent in a plasma channel just before a high-intensity laser pulse, is trapped in the laser wakefield, considerably compressed and accelerated to an ultrarelativistic energy. In this paper we show the possibility of the generation of an extremely short (on the order of 1   μm long or a few femtoseconds in duration relativistic-electron-bunch by this mechanism. The initial electron bunch, which can be generated, for example, by a laser-driven photocathode rf gun, should have an energy of a few hundred keVs to a few MeVs, a duration in the picosecond range or less and a relatively low concentration. The trapping conditions and parameters of an accelerated bunch are investigated. The laser pulse dynamics as well as a possible experimental setup for the demonstration of the injection scheme are also considered.

  9. Observation of coherently enhanced tunable narrow-band terahertz transition radiation from a relativistic sub-picosecond electron bunch train

    Energy Technology Data Exchange (ETDEWEB)

    Piot, P. [Northern Illinois Univ., DeKalb, IL (United States); Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Sun, Y. -E [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Maxwell, T. J. [Northern Illinois Univ., DeKalb, IL (United States); Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Ruan, J. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Lumpkin, A. H. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Rihaoui, M. M. [Northern Illinois Univ., DeKalb, IL (United States); Thurman-Keup, R. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2011-06-27

    We experimentally demonstrate the production of narrow-band (δf/f ~ =20% at f ~ = 0.5 THz) THz transition radiation with tunable frequency over [0.37, 0.86] THz. The radiation is produced as a train of sub-picosecond relativistic electron bunches transits at the vacuum-aluminum interface of an aluminum converter screen. In addition, we show a possible application of modulated beams to extend the dynamical range of a popular bunch length diagnostic technique based on the spectral analysis of coherent radiation.

  10. MicroRNA Expression Profiling Identifies Molecular Diagnostic Signatures for Anaplastic Large Cell Lymphoma

    DEFF Research Database (Denmark)

    Liu, Cuiling; Iqbal, Javeed; Teruya-Feldstein, Julie

    2013-01-01

    Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimm...

  11. Bunch cleaning strategies and experiments at the Advanced Photon Source.

    Energy Technology Data Exchange (ETDEWEB)

    Sereno, N. S.

    1999-04-15

    The Advanced Photon Source (APS) design incorporated a positron accumulator ring (PAR) as part of the injector chain. In order to increase reliability and accommodate other uses of the injector, APS will run with electrons, eliminating the need for the PAR, provided another method of eliminating rf bucket pollution in the APS is found. Satellite bunches captured from an up to 30-ns-long beam from the linac need to be removed in the injector synchrotron and storage ring. The bunch cleaning method considered here relies on driving a stripline kicker with an amplitude modulated (AM) carrier signal where the carrier is at a revolution harmonic sideband corresponding to the vertical tune. The envelope waveform is phased so that all bunches except a single target bunch (eventually to be injected into the storage ring) are resonated vertically into a scraper. The kicker is designed with a large enough shunt impedance to remove satellite bunches from the injection energy of 0.4 GeV up to 1 GeV. Satellite bunch removal in the storage ring relies on the single bunch current tune shift resulting from the machine impedance. Small bunches remaining after initial preparation in the synchrotron may be removed by driving the beam vertically into a scraper using a stripline kicker operating at a sideband corresponding to the vertical tune for small current bunches. In this paper both design specifications and bunch purity measurements are reported for both the injector synchrotron and storage ring.

  12. Measuring the electron beam energy in a magnetic bunch compressor

    Energy Technology Data Exchange (ETDEWEB)

    Hacker, Kirsten

    2010-09-15

    Within this thesis, work was carried out in and around the first bunch compressor chicane of the FLASH (Free-electron LASer in Hamburg) linear accelerator in which two distinct systems were developed for the measurement of an electron beams' position with sub-5 {mu}m precision over a 10 cm range. One of these two systems utilized RF techniques to measure the difference between the arrival-times of two broadband electrical pulses generated by the passage of the electron beam adjacent to a pickup antenna. The other system measured the arrival-times of the pulses from the pickup with an optical technique dependent on the delivery of laser pulses which are synchronized to the RF reference of the machine. The relative advantages and disadvantages of these two techniques are explored and compared to other available approaches to measure the same beam property, including a time-of-flight measurement with two beam arrival-time monitors and a synchrotron light monitor with two photomultiplier tubes. The electron beam position measurement is required as part of a measurement of the electron beam energy and could be used in an intra-bunch-train beam-based feedback system that would stabilize the amplitude of the accelerating field. By stabilizing the accelerating field amplitude, the arrival-time of the electron beam can be made more stable. By stabilizing the electron beam arrival-time relative to a stable reference, diagnostic, seeding, and beam-manipulation lasers can be synchronized to the beam. (orig.)

  13. Breast cancer: determining the genetic profile from ultrasound-guided percutaneous biopsy specimens obtained during the diagnostic workups.

    Science.gov (United States)

    López Ruiz, J A; Zabalza Estévez, I; Mieza Arana, J A

    2016-01-01

    To evaluate the possibility of determining the genetic profile of primary malignant tumors of the breast from specimens obtained by ultrasound-guided percutaneous biopsies during the diagnostic imaging workup. This is a retrospective study in 13 consecutive patients diagnosed with invasive breast cancer by B-mode ultrasound-guided 12 G core needle biopsy. After clinical indication, the pathologist decided whether the paraffin block specimens seemed suitable (on the basis of tumor size, validity of the sample, and percentage of tumor cells) before sending them for genetic analysis with the MammaPrint® platform. The size of the tumors on ultrasound ranged from 0.6cm to 5cm. In 11 patients the preserved specimen was considered valid and suitable for use in determining the genetic profile. In 1 patient (with a 1cm tumor) the pathologist decided that it was necessary to repeat the core biopsy to obtain additional samples. In 1 patient (with a 5cm tumor) the specimen was not considered valid by the genetic laboratory. The percentage of tumor cells in the samples ranged from 60% to 70%. In 11/13 cases (84.62%) it was possible to do the genetic analysis on the previously diagnosed samples. In most cases, regardless of tumor size, it is possible to obtain the genetic profile from tissue specimens obtained with ultrasound-guided 12 G core biopsy preserved in paraffin blocks. Copyright © 2015 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  14. A comparison of boundary-layer heights inferred from wind-profiler backscatter profiles with diagnostic calculations using regional model forecasts

    Energy Technology Data Exchange (ETDEWEB)

    Baltink, H.K.; Holtslag, A.A.M. [Royal Netherlands Meteorological Inst., KNMI, De Bilt (Netherlands)

    1997-10-01

    From October 1994 through January 1997 the Tropospheric Energy Budget Experiment (TEBEX) was executed by KNMI. The main objectives are to study boundary layer processes and cloud variability on the sub-grid scale of present Global Climate Models and to improve the related sub-grid parametrizations. A suite of instruments was deployed to measure a large number of variables. Measurements to characterize ABL processes were focussed around the 200 m high meteorological observation tower of the KNMI in Cabauw. In the framework of TEBEX a 1290 MHz wind-profiler/RASS was installed in July 1994 at 300 m from tower. Data collected during TEBEX are used to assess the performance of a Regional Atmospheric Climate Model (RACMO). This climate model runs also in a operational forecast mode once a day. The diagnostic ABL-height (h{sub model}) is calculated from the RACMO forecast output. A modified Richardson`s number method extended with an excess parcel temperature is applied for all stability conditions. We present the preliminary results of a comparison of h{sub model} from forecasts with measured h{sub TS} derived from profiler and sodar data for July 1995. (au)

  15. Quality and Impact of Indian Doppler Weather Radar Wind Profiles: A Diagnostic Study

    Science.gov (United States)

    Sandeep, A.; Prasad, V. S.; Johny, C. J.

    2017-07-01

    In the tropics, efficient weather forecasts require high-quality vertical profiles of winds to overcome improper coupling of mass and wind fields and balance relationships in the region. The India Meteorological Department (IMD) operates the network of Doppler Weather Radar (DWR) in microwave frequencies (S-band or C-band) at various locations in India. The National Centre for Medium Range Weather Forecasting (NCMRWF) receives the volume velocity processing (VVP) wind profiles from all DWRs through the Global Telecommunication System (GTS) network in near real time. The radar VVP wind is a mean horizontal wind derived at different heights from radial velocities suitable for numerical weather prediction applications. Three numerical experiments, CNTL (without VVP winds), 3DVAR and HYBRID with the assimilation of VVP winds by means of 3-dimensional variational (3dvar) and hybrid data assimilation systems were conducted using the NCMRWF Global Forecast System (NGFS) model. This study had two objectives: (1) quality assessment of VVP winds and (2) investigation of the impact of VVP wind profiles on NGFS model forecast. The quality of VVP wind profiles was assessed against the NGFS model background and radiosonde wind profiles. The absolute values of zonal and meridional wind observation minus background (O-B) increased with the pressure for all DWRs. All radars exhibited the accepted (rejected) ratio as a decreasing (increasing) function of pressure. The resemblance between the zonal and meridional O-B statistics for 3DVAR and HYBRID experiments is apparently remarkable. The accepted VVP winds and radiosonde winds in both experiments (3DVAR and HYBRID) were consistent. The correlation coefficient ( R) was higher at Patna (Patiala) for zonal (meridional) winds in the 3DVAR experiment and at Patna (Jaipur) in the HYBRID experiment. At Chennai, the R value was lower in both the experiments for both wind components. However, because of the assimilation of VVP winds by

  16. Stability of bunched fluxons in magnetically coupled Josephson junctions

    DEFF Research Database (Denmark)

    Grønbech-Jensen, Niels; Cai, David; Samuelsen, Mogens Rugholm

    1993-01-01

    The stability of bunched fluxon states in inductively coupled Josephson junctions is analyzed for fluxons of both equal and opposite polarity. We demonstrate that unipolar fluxons may form stable bunched states if the velocity is above a given threshold. The stability of these bunched states is b...... is based on the existence of two characteristic velocities in the coupled system. The result of analytical stability analysis is in excellent agreement with the results of numerical simulations....

  17. Distortion of Crabbed Bunch Due to the Electron Cloud

    Energy Technology Data Exchange (ETDEWEB)

    Wang, L; Raubenheimer, T.; /SLAC

    2008-05-28

    In order to improve the luminosity, two crab cavities have been installed in KEKB HER and LER [1]. Since there is only one crab cavity in each ring, the crab cavity generates a horizontally titled bunch along the whole ring. The achieved specific luminosity with crabbed bunch is higher, but it is not as high as that from beam-beam simulation [2]. One of the suspicions is the electron cloud. The electron cloud in LER (positron beam) may distort the crabbed bunch and cause the luminosity drop. This note briefly estimates the bunch shape distortion due to the electron cloud in KEKB LER.

  18. Tax Bunching, Income Shifting and Self-employment

    DEFF Research Database (Denmark)

    le Maire, Christian Daniel; Schjerning, Bertel

    2013-01-01

    This paper proposes a dynamic extension to Saez (2010) bunching formula that allows us to distinguish bunching based on real responses and income shifting. We provide direct evidence of income shifting and pronounced bunching in taxable income for the Danish self-employed. If income shifting...... was neglected in this case, we would estimate a taxable income elasticity in the range of 0.43-0.53 and conclude that taxable incomes were highly sensitive to changes in marginal tax rates. We show, however, that more than half of the bunching in taxable income is driven by intertemporal income shifting...

  19. Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility.

    Directory of Open Access Journals (Sweden)

    Michael J Baine

    2011-02-01

    Full Text Available It is well known that many malignancies, including pancreatic cancer (PC, possess the ability to evade the immune system by indirectly downregulating the mononuclear cell machinery necessary to launch an effective immune response. This knowledge, in conjunction with the fact that the trancriptome of peripheral blood mononuclear cells has been shown to be altered in the context of many diseases, including renal cell carcinoma, lead us to study if any such alteration in gene expression exists in PC as it may have diagnostic utility.PBMC samples from 26 PC patients and 33 matched healthy controls were analyzed by whole genome cDNA microarray. Three hundred eighty-three genes were found to be significantly different between PC and healthy controls, with 65 having at least a 1.5 fold change in expression. Pathway analysis revealed that many of these genes fell into pathways responsible for hematopoietic differentiation, cytokine signaling, and natural killer (NK cell and CD8+ T-cell cytotoxic response. Unsupervised hierarchical clustering analysis identified an eight-gene predictor set, consisting of SSBP2, Ube2b-rs1, CA5B, F5, TBC1D8, ANXA3, ARG1, and ADAMTS20, that could distinguish PC patients from healthy controls with an accuracy of 79% in a blinded subset of samples from treatment naïve patients, giving a sensitivity of 83% and a specificity of 75%.In summary, we report the first in-depth comparison of global gene expression profiles of PBMCs between PC patients and healthy controls. We have also identified a gene predictor set that can potentially be developed further for use in diagnostic algorithms in PC. Future directions of this research should include analysis of PBMC expression profiles in patients with chronic pancreatitis as well as increasing the number of early-stage patients to assess the utility of PBMCs in the early diagnosis of PC.

  20. Effects of bunch rot (Botrytis cinerea) and powdery mildew (Erysiphe necator) fungal diseases on wine aroma

    Science.gov (United States)

    Lopez Pinar, Angela; Rauhut, Doris; Ruehl, Ernst; Buettner, Andrea

    2017-03-01

    This study aimed to characterize the effects of bunch rot and powdery mildew on the primary quality parameter of wine, the aroma. The influence of these fungal diseases was studied by comparative Aroma Extract Dilution Analyses (AEDA) and sensory tests. The effect of bunch rot was investigated on three grape varieties, namely White Riesling, Red Riesling and Gewürztraminer and that of powdery mildew on the hybrid Gm 8622-3; thereby, samples were selected that showed pronounced cases of infection to elaborate potential currently unknown effects. Both infections revealed aromatic differences induced by these fungi. The sensory changes were not associated with one specific compound only, but were due to quantitative variations of diverse substances. Bunch rot predominantly induced an increase in the intensities of peach-like/fruity, floral and liquor-like/toasty aroma notes. These effects were found to be related to variations in aroma substance composition as monitored via AEDA, mainly an increase in the FD factors of lactones and a general moderate increase of esters and alcohols. On the other hand, powdery mildew decreased the vanilla-like character of the wine while the remaining sensory attributes were rather unaffected. Correspondingly, FD factors of the main aroma constituents were either the same or only slightly modified by this disease. Moreover, bunch rot influenced the aroma profiles of the three varieties studied to a different degree. In hedonic evaluation, bunch rot-affected samples were rated as being more pleasant in comparison to their healthy controls in all three varieties while the powdery mildew-affected sample was rated as being less pleasant than its healthy control.

  1. Single bunch stability to monopole excitation

    Directory of Open Access Journals (Sweden)

    Sam Heifets

    1999-04-01

    Full Text Available We study single bunch stability with respect to monopole longitudinal oscillations in electron storage rings. Our analysis is different from the standard approach based on the linearized Vlasov equation. Rather, we reduce the full nonlinear Fokker-Planck equation to a Schrödinger-like equation which is subsequently analyzed by perturbation theory. We show that the Haissinski solution [Nuovo Cimento Soc. Ital. Fis. 18B, 72 (1973] may become unstable with respect to monopole oscillations and derive a stability criterion in terms of the ring impedance. We then discuss this criterion and apply it to a broadband resonator impedance model.

  2. Bunch-by-Bunch Analysis of the LHC Heavy-Ion Luminosity

    CERN Document Server

    Schaumann, M

    2013-01-01

    After the first run in 2010 [1], the LHC continued its heavy-ion operation with collisions of lead nuclei in late 2011. The beam dynamics of the high intensity lead beams are strongly influenced by intra-beam scattering (IBS), especially on the injection plateau. Each train injected from the SPS spends a different time at injection, introducing significant changes from train to train. Within the trains there is an even larger spread imprinted by the SPS injection plateau. This results in a spread of the luminosity produced in each bunch crossing. The particle losses during collisions are dominated by nuclear electromagnetic processes, leading to a non-exponential intensity decay during the fill and short luminosity lifetime at 3:5Z TeV. The lu- minosity, emittance, intensity and bunch length evolution of the 2011 run was analysed bunch-by-bunch and compared with simulations. Based on this analysis, estimates of the potential luminosity performance at 6:5Z TeV, after the present shutdown, are given.

  3. Diagnostic Power of Broad Emission Line Profiles in Searches for Binary Supermassive Black Holes.

    Science.gov (United States)

    Nguyen, Khai; Bogdanovic, Tamara

    2015-01-01

    Motivated by advances in observational searches for sub-parsec supermassive black hole binaries (SBHBs) made in the past few years we develop a semi-analytic model to describe the spectral emission line signatures of these systems. The goal of this work is to test one of the leading models of binary accretion flows in the literature: SBHB in a circumbinary disk. In this context, we model SBHB accretion flows as a set of three accretion disks: two mini-disks that are gravitationally bound to the individual black holes and a circumbinary disk that forms a common envelope about a gravitationally bound binary. We find that emission line profiles tend to have different statistical properties depending on the semi-major axis, mass ratio, eccentricity of the binary, and the alignment of the triple-disk system, and can in principle be used to infer the statistical distribution of these parameters.

  4. Profiling the clinical presentation of diagnostic characteristics of a sample of symptomatic TMD patients

    Directory of Open Access Journals (Sweden)

    e Silva Machado Luciana

    2012-08-01

    Full Text Available Abstract Background Temporomandibular disorder (TMD patients might present a number of concurrent clinical diagnoses that may be clustered according to their similarity. Profiling patients’ clinical presentations can be useful for better understanding the behavior of TMD and for providing appropriate treatment planning. The aim of this study was to simultaneously classify symptomatic patients diagnosed with a variety of subtypes of TMD into homogenous groups based on their clinical presentation and occurrence of comorbidities. Methods Clinical records of 357 consecutive TMD patients seeking treatment in a private specialized clinic were included in the study sample. Patients presenting multiple subtypes of TMD diagnosed simultaneously were categorized according to the AAOP criteria. Descriptive statistics and two-step cluster analysis were used to characterize the clinical presentation of these patients based on the primary and secondary clinical diagnoses. Results The most common diagnoses were localized masticatory muscle pain (n = 125 and disc displacement without reduction (n = 104. Comorbidity was identified in 288 patients. The automatic selection of an optimal number of clusters included 100% of cases, generating an initial 6-cluster solution and a final 4-cluster solution. The interpretation of within-group ranking of the importance of variables in the clustering solutions resulted in the following characterization of clusters: chronic facial pain (n = 36, acute muscle pain (n = 125, acute articular pain (n = 75 and chronic articular impairment (n = 121. Conclusion Subgroups of acute and chronic TMD patients seeking treatment can be identified using clustering methods to provide a better understanding of the clinical presentation of TMD when multiple diagnosis are present. Classifying patients into identifiable symptomatic profiles would help clinicians to estimate how common a disorder is within a population of

  5. Serum peptide/protein profiling by mass spectrometry provides diagnostic information independently of CA125 in women with an ovarian tumor

    DEFF Research Database (Denmark)

    Callesen, Anne; Madsen, Jonna S; Iachina, Maria

    2010-01-01

    In the present study, the use of a robust and sensitive mass spectrometry based protein profiling analysis was tested as diagnostic tools for women with an ovarian tumor. The potential additional diagnostic value of serum protein profiles independent of the information provided by CA125 were also...... investigated. Protein profiles of 113 serum samples from women with an ovarian tumor (54 malign and 59 benign) were generated using MALDI-TOF MS. A total of 98 peaks with a significant difference (povarian tumors were identified. After...... average linkage clustering, a profile of 46 statistical significant mass peaks was identified to distinguish malignant tumors and benign tumors/cysts. In the subgroup of women with normal CA125 values (

  6. Quality Assessment of Soaps Produced from Palm Bunch Ash ...

    African Journals Online (AJOL)

    Michael Horsfall

    ABSTRACT: The making of soap using vegetable matter (palm bunch waste) was examined. All the factors that impact blackish on the soap products after saponification process were studied with a view to remedying them. The remedial process involved subjecting the dried palm bunch matter to total combustion, soaking, ...

  7. Intermediate Review of Single Bunch Collective Effects in the LHC

    CERN Document Server

    Angal-Kalinin, Deepa; Vos, L

    2002-01-01

    This paper presents an intermediate review of the single bunch collective effects in the LHC. It first reviews the LHC impedance budget including all elements for which a design is presently available. Then, based on this updated budget, the corresponding rise times and thresholds for single bunch instabilities are evaluated and discussed.

  8. Evaluation of fruit and bunch traits in black Sigatoka resistant ...

    African Journals Online (AJOL)

    Studies involving the evaluation of fruit and bunch characteristics of twenty seven cultivars of plantain and banana were undertaken. Results showed that bunch weight of plantain hybrid, 25344-18, differed significantly (P<0.05) from all other genotypes except SH 3362, with an average of 20.8 kg plant. The number of hands ...

  9. Responses of savanna lawn and bunch grasses to water limitation

    NARCIS (Netherlands)

    van der Plas, Alfons; Zeinstra, Patricia; Veldhuis, Michiel; Fokkema, Rienk; Tielens, Elske; Howison, Ruth; Olff, Han

    The grass layer of African savannas consists of two main vegetation types: grazing lawns, dominated by short, mostly clonally reproducing grasses, and bunch grasslands, dominated by tall bunch grasses. This patchy distribution of vegetation types is mostly created by large herbivores, which

  10. Instability during bunch shortening of an electron-cooled beam

    Directory of Open Access Journals (Sweden)

    M. Takanaka

    2003-10-01

    Full Text Available Bunch shortening causes an electron-cooled beam to be space charge dominated at low energies. Instability during the bunch shortening has been studied using a particle-tracking program where the 3D space-charge field due to the beam is calculated with a simplifying model.

  11. LHC Report: spring cleaning over, bunches of luminosity

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Scrubbing was completed on Wednesday 13 April. The run had seen over 1000 bunches per beam successfully circulating at 450 GeV. Measurements showed that electron cloud activity in the cold regions had been suppressed. A decrease of vacuum activity in the warm regions demonstrated that the cleaning had also achieved the required results there. As discussed in the last Bulletin, the scrubbing was performed with high intensity bunches with 50 nanosecond spacing. Given the potential luminosity performance with this spacing (more bunches, higher bunch intensity from the injectors) and in the light of the results of the scrubbing run, the decision was taken to continue the 2011 physics run with this bunch spacing.   A few issues with 50 nanosecond spacing had to be resolved when standard operations for luminosity production resumed. Once things had been tidied up, stable beams were provided for the experiments, firstly with 228 bunches per beam and then with 336 bunches per beam. The 336 bunch fill that w...

  12. Bunched soliton states in weakly coupled sine-Gordon systems

    DEFF Research Database (Denmark)

    Grønbech-Jensen, N.; Samuelsen, Mogens Rugholm; Lomdahl, P. S.

    1990-01-01

    The interaction between solitons of two weakly coupled sine-Gordon systems is considered. In particular, the stability of bunched states is investigated, and perturbation results are compared with numerical results.......The interaction between solitons of two weakly coupled sine-Gordon systems is considered. In particular, the stability of bunched states is investigated, and perturbation results are compared with numerical results....

  13. Cooling and bunching of ion beams for collinear laser spectroscopy

    CERN Document Server

    Nieminen, A; Billowes, J; Forest, D H; Griffith, J A R; Huikari, J; Jokinen, A; Moore, I D; Moore, R; Tungate, G; Äystö, J

    2003-01-01

    A greatly increased sensitivity in collinear laser spectroscopy experiments has been achieved by the application of new on-line ion cooling and bunching techniques. Cooling of a low-energy ion beam to low emittance and low velocity spread is shown to increase the peak efficiency while bunching the beam results in highly efficient background suppression.

  14. Femtosecond electron-bunch dynamics in laser wakefields and vacuum

    NARCIS (Netherlands)

    Khachatryan, A.G.; Irman, A.; van Goor, F.A.; Boller, Klaus J.

    2007-01-01

    Recent advances in laser wakefield acceleration demonstrated the generation of extremely short (with a duration of a few femtoseconds) relativistic electron bunches with relatively low (of the order of couple of percent) energy spread. In this article we study the dynamics of such bunches in drift

  15. Coupled-Beam and Coupled-Bunch Instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Burov, Alexey [Fermilab

    2016-06-23

    A problem of coupled-beam instability is solved for two multibunch beams with slightly different revolution frequencies, as in the Fermilab Recycler Ring (RR). Sharing of the inter-bunch growth rates between the intra-bunch modes is described. The general analysis is applied to the RR; possibilities to stabilize the beams by means of chromaticity, feedback and Landau damping are considered.

  16. Bunch Length Measurements at the SLS Linac Using Electro Optical Sampling

    CERN Document Server

    Steffen, Bernd; Schmüser, Peter; Simrock, Stefan

    2004-01-01

    The temporal profile of the electron bunches in the SLS Linac was determined by means of electro-optical techniques. In a first experiment a mode locked Ti:Sa Laser with 15 fs pulse width (FWHM) was used for coincidence and sampling measurements between the laser pulse and the coherent transition radiation (CTR) generated by short electron bunches. A synchronization accuracy of 70 fs rms between the 3 GHz Linac RF and the 81 MHz repetition frequency of the laser was achieved, which is important for the optimum time resolution of the applied electro-optical sampling technique. In a second experiment a mode locked Nd:YAG laser with 400 ps long pulses will be used for electro-optical autocorrelation measurements between the CTR and the laser pulses. This alternative technique promises single shot capability and requires much relaxed synchronization stability between laser and electron beam.

  17. Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.

    Science.gov (United States)

    Yamashita, Keishi; Sakuramoto, Shinichi; Watanabe, Masahiko

    2011-01-01

    Knowledge about the molecular profile of tumor tissues is crucial to effectively target cancer cells, because cancer is a genetic disease that involves multiple genetic and epigenetic alterations. Prominent aberrations include gene mutation, amplification, loss or deletion, as well as epigenetic alterations of the promoter DNA CpG islands. All of these aberrations can lead to dynamic changes in cancer cells, as demonstrated using resected tumor samples. There are two distinct pathological types of gastric cancer: the diffuse type and the intestinal type of gastric cancer. Diffuse type gastric cancer harbors aberrations in the FGFR2/ErbB3/PI3 kinase pathway, while intestinal type gastric cancer has an activated ErbB2 oncogenic pathway. On the other hand, the prometastatic oncogene PRL-3 is commonly activated in both types of advanced gastric cancer, and might represent a relevant therapeutic target for gastric cancer with lymph node metastasis or peritoneal dissemination. Numerous tumor suppressor genes can inhibit such oncogenic pathways, and DNA methylation in CpG islands of gene promoters is frequently found to suppress the expression of such genes in gastric cancer. Helicobacter pylori infection in normal gastric mucosa may cause p53 mutations through activation of activation-induced cytidine deaminase (AID) and/or promoter DNA methylation of E-cadherin, an initiator of gastric cancer, and such abnormalities are found even in the precancerous stage of gastric carcinogenesis. In addition, it has been demonstrated that there are highly relevant methylation genes involved in cancer (HRMGs) that exhibit very frequent cancer-specific methylation in gastric cancer. Such genes are potential targets for cancer treatment, and might also serve as biomarkers of gastric cancer for either the diagnosis or for determining the prognosis or the response to treatment.

  18. Electron Beam Diagnostics Of The JLAB UV FEL

    Energy Technology Data Exchange (ETDEWEB)

    Evtushenko, Pavel; Benson, Stephen; Biallas, George; Coleman, James; Dickover, Cody; Douglas, David; Marchlik, Matthew; Sexton, Daniel; Tennant, Christopher

    2011-03-01

    In this contribution we describe various systems and aspects of the electron beam diagnostics of the JLab UV FEL. The FEL is installed on a new bypass beam line at the existing 10 kW IR Upgrade FEL. Here, we describe a set of the following systems. A combination of OTR and phosphor viewers is used for measurements of the transverse beam profile, transverse emittance, and Twiss parameters. This system is also used for alignment of the optical cavity of the UV oscillator and to ensure the overlap between the electron beam and optical mode in the FEL wiggler. A system of beam position monitors equipped with log-amp based BPM electronics. Bunch length on the order of 120 fs RMS is measured with the help of a modified Martin-Puplett interferometer. The longitudinal transfer function measurement system is used to set up bunch compression in an optimal way, such that the LINAC RF curvature is compensated using only higher order magnetic elements of the beam transport. This set of diagnostic systems made a significant contribution in achieving first lasing of the FEL after only about 60 hours of beam operation.

  19. Design of low energy bunch compressors with space charge effects

    Directory of Open Access Journals (Sweden)

    A. He

    2015-01-01

    Full Text Available In this paper, we explore a method to manipulate low energy electron bunches in a space charge dominated regime, and we use this method to design low energy linac bunch compressors to compress electron bunches in a space charge dominated regime. In the method, we use the space charge effects instead of avoiding them; i.e., we use the space charge forces to generate the required energy chirp instead of the ordinary method which uses the rf accelerating system to generate the chirp. We redefine the concepts of the dispersion function and beta functions in a space charge dominated regime to guide the optimization. Using this method, we study the low energy (5–22 MeV linac bunch compressor design to produce short (∼150  fs and small size (∼30  μm bunches for the electron beam slicing project. The low energy linac bunch compressors work in a space charge dominated regime, and the bunches at the downstream of the gun have a negative energy chirp due to the space charge effects. To provide compression for the negative energy chirped bunch, we design a positive R_{56} dispersive section using a four-dipole chicane with several quadrupole magnets. We have designed low energy linac bunch compressors with different photocathode rf guns. For example, one linac bunch compressor with the BNL photocathode electron rf gun has achieved a low energy bunch with the 166 fs rms bunch length, 28 and 31  μm rms beam size in the vertical and horizontal directions, respectively, at 5 MeV with 50 pC charge. Another example with LBNL’s very-high frequency gun has achieved a low energy bunch with the 128 fs rms bunch length, 42 and 25  μm rms beam size in the vertical and horizontal directions, respectively, at 22 MeV with 200 pC charge.

  20. ACHROMAT WITH LINEAR SPACE CHARGE FOR BUNCHED BEAMS

    Energy Technology Data Exchange (ETDEWEB)

    RAPARIA,D.; ALESSI,J.G.; LEE,Y.Y.; WENG,W.T.

    1998-08-23

    The standard definition for an achromat is a transport line having zero values for the spatial dispersion (R16) and the angular dispersion (RZ6). For a bunched beam with linear space charge this definition of achromaticity does not hold. The linear space charge in the presence of a bend provides coupling between (a) bunch spatial width and bunch length (R1.5) and (b) bunch angular spread and bunch length (R25). Therefore, achromaticity should be redefined as a line having zero values of the spatial dispersion (R16), the angular dispersion (R26), and matrix elements R15 and R25. These additional conditions (R15=R25=0) can be achieved, for example, with two small RF cavities at appropriate locations in the achromat, to cancel space charge effects. An example of the application of this technique to the Spallation Neutron Source (SNS) high energy beam transport line is presented.

  1. Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: Towards metabolomics diagnostics

    NARCIS (Netherlands)

    Szymańska, E.; Bouwman, J.; Strassburg, K.; Vervoort, J.; Kangas, A.J.; Soininen, P.; Ala-Korpela, M.; Westerhuis, J.; Duynhoven, J.P.M. van; Mela, D.J.; MacDonald, I.A.; Vreeken, R.J.; Smilde, A.K.; Jacobs, D.M.

    2012-01-01

    Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136 lipid

  2. Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: Towards metabolomics diagnostics

    NARCIS (Netherlands)

    Szymanska, E.; Bouwman, J.; Strassburg, K.; Vervoort, J.J.M.; Kangas, A.J.; Soininen, P.; Ala-Korpela, M.; Westerhuis, J.A.; Duynhoven, van J.P.M.; Mela, D.J.; Macdonald, I.A.; Vreeken, R.J.; Smilde, A.K.; Jacobs, D.M.

    2012-01-01

    Abstract Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136

  3. Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics

    NARCIS (Netherlands)

    Szymańska, E.; Bouwman, J.; Strassburg, K.; Vervoort, J.; Kangas, A.J.; Soininen, P.; Ala-Korpela, M.; Westerhuis, J.; van Duynhoven, J.P.M.; Mela, D.J.; Macdonald, I.A.; Vreeken, R.J.; Smilde, A.K.; Jacobs, D.M.

    2012-01-01

    Obesity is a risk factor for cardiovascular diseases and type 2 diabetes especially when the fat is accumulated to central depots. Novel biomarkers are crucial to develop diagnostics for obesity and related metabolic disorders. We evaluated the associations between metabolite profiles (136 lipid

  4. Correction of unevenness in recycler beam profile

    Energy Technology Data Exchange (ETDEWEB)

    Crisp, J.; Hu, M.; Ng, K.Y.; /Fermilab

    2006-05-01

    A beam confined between two rf barriers in the Fermilab Recycler Ring exhibits very uneven longitudinal profile. This leads to the consequence that the momentum-mined antiproton bunches will have an intolerable variation in bunch intensity. The observed profile unevenness is the result of a tiny amount of rf imperfection and rf beam-loading. The profile unevenness can be flattened by feeding back the uneven rf fan-back gap voltage to the low-level rf.

  5. Gene expression profiling identifies platelet-derived growth factor as a diagnostic molecular marker for papillary thyroid carcinoma.

    Science.gov (United States)

    Yano, Yukiko; Uematsu, Naoya; Yashiro, Tohru; Hara, Hisato; Ueno, Ei; Miwa, Masanao; Tsujimoto, Gozoh; Aiyoshi, Yuji; Uchida, Kazuhiko

    2004-03-15

    Cancer diagnostics and therapeutics are often based on clinically relevant markers that are expressed specifically in a malignant tissue at levels higher than in normal tissue. We examined potential markers for papillary thyroid carcinoma (PTC) by monitoring PTC-specific gene expression using cDNA microarray. Gene expression profiles for PTC tissue, normal thyroid tissue, and healthy peripheral blood cells were compared by use of a human 4000-gene cDNA microarray. Protein expressions of the up-regulated genes in PTC were examined in thyroid tissues by immunohistochemistry. Sixty-four genes were overexpressed in PTC tissue relative to normal thyroid tissue and healthy peripheral blood cells. The genes that were up-regulated in PTC were involved in cell cycle regulation, DNA damage response, angiogenesis, and oncogenesis. Among these genes, basic fibroblast growth factor and platelet-derived growth factor were identified by immunochemical methods as proteins that are specifically expressed at high levels in thyroid neoplasms. Basic fibroblast growth factor, which has been identified as a biomarker for PTC, was overexpressed in 54% of PTC cases, 67% of follicular thyroid carcinomas, and 36% of benign thyroid neoplasms. Platelet-derived growth factor was overexpressed in 81% of PTC cases and 100% of follicular carcinomas, but was immunonegative in normal thyroid tissues and benign thyroid neoplasms. Platelet-derived growth factor may be a potential biomarker for PTC and follicular carcinoma. Expression profile analysis using a microarray followed by immunohistochemical study can be used to facilitate the development of molecular biomarkers for cancer.

  6. Single-shot method for measuring femtosecond bunch length in linac-based free-electron lasers

    Directory of Open Access Journals (Sweden)

    Z. Huang

    2010-09-01

    Full Text Available There is growing interest in the generation and characterization of femtosecond and subfemtosecond pulses from linac-based free-electron lasers (FELs. In this report, following the method of Ricci and Smith [Phys. Rev. ST Accel. Beams 3, 032801 (2000PRABFM1098-440210.1103/PhysRevSTAB.3.032801], we investigate the measurement of the longitudinal bunch profile of an ultrashort electron bunch produced by these FELs. We show that this method can be applied in a straightforward manner at x-ray FEL facilities such as the Linac Coherent Light Source by slightly adjusting the second bunch compressor followed by running the bunch on an rf zero-crossing phase of the final linac. We find that the linac wakefield strongly perturbs the measurement, and through analysis show that it can be compensated in a simple way. We demonstrate the effectiveness of this method and wakefield compensation through numerical simulations, including effects of coherent synchrotron radiation and longitudinal space charge. When used in conjunction with a high-resolution electron spectrometer, this method potentially reveals the temporal profile of the electron beam down to the femtosecond and subfemotsecond scale.

  7. Coherent Transition Radiation to Measure the SLAC Electron Bunch Length

    CERN Document Server

    Muggli, Patric; Hogan, Mark; Ischebeck, Rasmus; Krejcik, Patrick; Schlarb, Holger; Siemann, Robert; Walz, Dieter

    2005-01-01

    Ultrashort electron bunches are now available at Stanford Linear Accelerator Center and are use mainly to produce short bursts of x-rays in a magnetic undulator and for plasma wakefield acceleration experiments. The shortest bunches have an rms longitudinal width of ˜10 microns, and a peak current of about 30 kA. Methods to measure such short bunch lengths include electro-optic modulation of a short laser pulse in a nonlinear crystal and coherent transition (CTR) autocorrelation. The transition radiation spectrum emitted by the bunches when traversing a 1 micron thin titanium foil is coherent for wavelengths longer that the bunch length and extends into the millimeter wavelength range. A CTR far-infrared autocorrelator was used to measure the bunch length as a function of the accelerator. The results obtained with this autocorrelator are the only measurements of the SLAC ultra-short bunches to date. Experimental results, as well as the limitations of the measurements and the future improvements to the autoco...

  8. Application of a Low-Energy Electron Beam as a Tool for ultrashort bunch length measurement in circular machines

    CERN Document Server

    Nikiforov, D A; Malyutin, D; Matveenko, A; Rusinov, K; Starostenko, A A

    2017-01-01

    A new diagnostic device designed for non-destructive ultrashort bunch length measurement is described. The operating principle of the device and the measuring technique are described. The possible scheme of arrangement of the device elements are described. The results of simulations of EBP application for different beams under investigation are presented. The quality requirements of the low energy testing beam are considered and resolving detector ability is determined.

  9. On compensating tune spread induced by space charge in bunched beams

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko V. N.; Wang, G.

    2014-05-09

    Space charge effects play significant role in modern-day accelerators. These effects frequently constrain attainable beam parameters in an accelerator, or, in an accelerator chain. They also could limit the luminosity of hadron colliders operating either at low energies or with a sub-TeV high brightness hadron beams. The latter is applied for strongly cooled proton and ion beams in eRHIC – the proposed future electron-ion collider at Brookhaven National Laboratory. A number of schemes for compensating space charge effects in a coasting (e.g. continuous) hadron beam were proposed and some of them had been tested. Using a proper transverse profile of the electron beam (or plasma column) for a coasting beam would compensate both the tune shift and the tune spread in the hadron beam. But all of these methods do not address the issue of tune spread compensation of a bunched hadron beam, e.g. the tune shift dependence on the longitudinal position inside the bunch. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with miss-matched longitudinal velocity to compensate the space charge induced tune-shift and tune spread. We present a number of practical examples of such system.

  10. Resistive wall wakefields of short bunches at cryogenic temperatures

    Directory of Open Access Journals (Sweden)

    G. Stupakov

    2015-03-01

    Full Text Available We present calculations of the longitudinal wakefields at cryogenic temperatures for extremely short bunches, characteristic for modern x-ray free electron lasers. The calculations are based on the equations for the surface impedance in the regime of the anomalous skin effect in metals. This paper extends and complements an earlier analysis of B. Podobedov, Phys. Rev. ST Accel. Beams 12, 044401 (2009. into the region of very high frequencies associated with bunch lengths in the micron range. We study in detail the case of a rectangular bunch distribution for parameters of interest of LCLS-II with a superconducting undulator.

  11. Developing electron beam bunching technology for improving light sources

    Energy Technology Data Exchange (ETDEWEB)

    Carlsten, B.E.; Chan, K.C.D.; Feldman, D.W. [and others

    1997-08-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The goal of this project was to develop a new electron bunch compression technology, experimentally demonstrate subpicosecond compression of bunches with charges on the order of 1 nC, and to theoretically investigate fundamental limitations to electron bunch compression. All of these goals were achieved, and in addition, the compression system built for this project was used to generate 22 nm light in a plasma-radiator light source.

  12. Interaction of an ion bunch with a plasma slab

    Energy Technology Data Exchange (ETDEWEB)

    Krasovitskiy, V. B., E-mail: krasovit@mail.ru [Russian Academy of Sciences, Keldysh Institute of Applied Mathematics (Russian Federation); Turikov, V. A. [Peoples’ Friendship University of Russia (Russian Federation)

    2016-11-15

    Charge neutralization of a short ion bunch passing through a plasma slab is studied by means of numerical simulation. It is shown that a fraction of plasma electrons are trapped by the bunch under the action of the collective charge separation field. The accelerated electrons generated in this process excite beam−plasma instability, thereby violating the trapping conditions. The process of electron trapping is also strongly affected by the high-frequency electric field caused by plasma oscillations at the slab boundaries. It is examined how the degree of charge neutralization depends on the parameters of the bunch and plasma slab.

  13. prevalence and diagnostic profile

    African Journals Online (AJOL)

    as dementia, mood, and psychotic disorders, either due to the primary disease process of HIV or secondary infection.1. Secondly ..... Table II: Demographics, general characteristics, psychiatric diagnoses and HIV serological sero-positivity of the total sample. HIV infected. HIV negative. Total sample. Mean age in years ...

  14. Investigation of transient processes at the DELTA electron storage ring using a digital bunch-by-bunch feedback system

    Energy Technology Data Exchange (ETDEWEB)

    Hoener, Markus

    2015-07-01

    At the 1.5-GeV synchrotron radiation source DELTA, operated by the TU Dortmund University, intensive synchrotron radiation in the spectral range from hard X-rays to THz radiation is generated by the circular deflection of highly relativistic electron bunches. Interacting with the vacuum chamber wall, the electron bunches create electric fields, which can act back on subsequent bunches. With increasing beam current, the excitation is enhanced so that the electron beam is unstable, which means that the electron bunches oscillate longitudinally or transversely relative to their reference position. The oscillations reduce the quality of the synchrotron radiation and limit the maximum storable beam current. Within the scope of this thesis, the beam instabilities at the storage ring were systematically investigated. A digital bunch-by-bunch feedback system was installed and commissioned, which allows to detect and digitize the position of each electron bunch at each turn. Based on the input signal, a correction signal is calculated in order to suppress transverse and longitudinal oscillation of the bunches. In addition, it is possible to excite dedicated bunches. The systematic excitation of all coupled-bunch modes allowed for the first time to determine the damping rates of all 192 eigenmodes of the electron beam. The current dependence of the damping rates was investigated and an instability threshold was found. Besides the investigation of multibunch instabilities, single-bunch instabilities are discussed. In addition, the acquisition unit of the digital feedback system can be triggered on external events. This was used to investigate the injection process and beam losses. It was shown that the transverse feedback system increases the injection efficiency. Another aspect of this thesis is the improvement of the signal quality of ultrashort coherent synchrotron radiation pulses, which are generated by the short-pulse facility at DELTA. The short-pulse facility is based

  15. Phase modulation of the bucket stops bunch oscillations at the Fermilab Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Tan, C.Y.; Burov, A.; /Fermilab

    2012-04-02

    Bunches in the Tevatron are known to exhibit longitudinal oscillations which persist indefinitely. These oscillations are colloquially called 'dancing bunches.' Although the dancing proton bunches do not cause single bunch emittance growth or beam loss at injection, they lead to bunch lengthening at collisions. In Tevatron operations, a longitudinal damper has been built which stops this dance and damps out coupled bunch modes. Recent theoretical work predicts that the dance can also be stopped by an appropriate change in the bunch distribution. This paper describes the Tevatron experiments which support this theory.

  16. Wake excited in plasma by an ultrarelativistic pointlike bunch

    Science.gov (United States)

    Stupakov, G.; Breizman, B.; Khudik, V.; Shvets, G.

    2016-10-01

    We study propagation of a relativistic electron bunch through a cold plasma assuming that the transverse and longitudinal dimensions of the bunch are much smaller than the plasma collisionless skin depth. Treating the bunch as a point charge and assuming that its charge is small, we derive a simplified system of equations for the plasma electrons and show that, through a simple rescaling of variables, the bunch charge can be eliminated from the equations. The equations demonstrate an ion cavity formed behind the driver. They are solved numerically and the scaling of the cavity parameters with the driver charge is obtained. A numerical solution for the case of a positively charged driver is also found.

  17. Dependence of bunch energy loss in cavities on beam velocity

    Directory of Open Access Journals (Sweden)

    Sergey S. Kurennoy

    1999-03-01

    Full Text Available Beam energy loss in a cavity can be easily computed for a relativistic bunch using time-domain codes like MAFIA or ABCI. However, for nonrelativistic beams the problem is more complicated because of difficulties with its numerical formulation in the time domain. We calculate the cavity loss factors for a bunch in frequency domain as a function of its velocity and compare results with the relativistic case.

  18. Velocity bunching of high-brightness electron beams

    Directory of Open Access Journals (Sweden)

    S. G. Anderson

    2005-01-01

    Full Text Available Velocity bunching has been recently proposed as a tool for compressing electron beam pulses in modern high brightness photoinjector sources. This tool is familiar from earlier schemes implemented for bunching dc electron sources, but presents peculiar challenges when applied to high current, low emittance beams from photoinjectors. The main difficulty foreseen is control of emittance oscillations in the beam in this scheme, which can be naturally considered as an extension of the emittance compensation process at moderate energies. This paper presents two scenarios in which velocity bunching, combined with emittance control, is to play a role in nascent projects. The first is termed ballistic bunching, where the changing of relative particle velocities and positions occur in distinct regions, a short high gradient linac, and a drift length. This scenario is discussed in the context of the proposed ORION photoinjector. Simulations are used to explore the relationship between the degree of bunching, and the emittance compensation process. Experimental measurements performed at the UCLA Neptune Laboratory of the surprisingly robust bunching process, as well as accompanying deleterious transverse effects, are presented. An unanticipated mechanism for emittance growth in bends for highly momentum chirped beam was identified and studied in these experiments. The second scenario may be designated as phase space rotation, and corresponds closely to the recent proposal of Ferrario and Serafini. Its implementation for the compression of the electron beam pulse length in the PLEIADES inverse Compton scattering (ICS experiment at LLNL is discussed. It is shown in simulations that optimum compression may be obtained by manipulation of the phases in low gradient traveling wave accelerator sections. Measurements of the bunching and emittance control achieved in such an implementation at PLEIADES, as well as aspects of the use of velocity-bunched beam directly

  19. VELOCITY BUNCHING OF HIGH-BRIGHTNESS ELECTRON BEAMS

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S G; Musumeci, P; Rosenzweig, J B; Brown, W J; England, R J; Ferrario, M; Jacob, J S; Thompson, M C; Travish, G; Tremaine, A M; Yoder, R

    2004-10-15

    Velocity bunching has been recently proposed as a tool for compressing electron beam pulses in modern high brightness photoinjector sources. This tool is familiar from earlier schemes implemented for bunching dc electron sources, but presents peculiar challenges when applied to high current, low emittance beams from photoinjectors. The main difficulty foreseen is control of emittance oscillations in the beam in this scheme, which can be naturally considered as an extension of the emittance compensation process at moderate energies. This paper presents two scenarios in which velocity bunching, combined with emittance control, is to play a role in nascent projects. The first is termed ballistic bunching, where the changing of relative particle velocities and positions occur in distinct regions, a short high gradient linac, and a drift length. This scenario is discussed in the context of the proposed ORION photoinjector. Simulations are used to explore the relationship between the degree of bunching, and the emittance compensation process. Experimental measurements performed at the UCLA Neptune Laboratory of the surprisingly robust bunching process, as well as accompanying deleterious transverse effects, are presented. An unanticipated mechanism for emittance growth in bends for highly momentum chirped beam was identified and studied in these experiments. The second scenario may be designated as phase space rotation, and corresponds closely to the recent proposal of Ferrario and Serafini. Its implementation for the compression of the electron beam pulse length in the PLEIADES inverse Compton scattering (ICS) experiment at LLNL is discussed. It is shown in simulations that optimum compression may be obtained by manipulation of the phases in low gradient traveling wave accelerator sections. Measurements of the bunching and emittance control achieved in such an implementation at PLEIADES, as well as aspects of the use of velocity-bunched beam directly in ICS experiments

  20. Bunched release of gases from oxide targets

    CERN Document Server

    Ravn, H L; Evensen, A H M; Jonsson, O C; Kugler, E; Lettry, Jacques; Tengblad, O; Barker, J; Drumm, P V; Hagebø, E; Hoff, P; Steffensen, K

    1997-01-01

    Targets made out of oxides of the alkaline earth metals have been shown at ISOLDE to be among the fastest targets for production of radioactive beams of the rare gas elements. In addition oxide target materials release nitrogen and seem to be the only ones which may release the element carbon due to its oxidation to the high temperature stable CO gas. Thick targets of MgO and CaO have been studied in connection with their use at the 1GeV pulsed proton beam from the PS-BOOSTER synchrotron. It is shown that the 2.4$\\mu$s short proton pulse causes a pronounced bunched release with short delay of these elements which gives rise to 100-200 ms wide pulses of radioactive ion beams. Pulse shapes and overall yields of ion beams of He, Ne and Ar isotopes are studied as function of temperature and proton pulse intensity. For carbon and nitrogen also the release as function of the observed ionic species C$^+$, CO$^+$, N$^+$ and N$_2^+$ is discussed.

  1. The LHC Transverse Coupled-Bunch Instability

    CERN Document Server

    Mounet, Nicolas; Métral, Elias

    In this thesis, the problem of the transverse coupled-bunch instabilities created by the Large Hadron Collider (LHC) beam-coupling impedance, that can possibly limit the machine operation, is addressed thanks to several new theories and tools. A rather complete vision of the problem is proposed here, going from the calculation of the impedances and wake functions of individual machine elements, to the beam dynamics study. Firstly, new results are obtained in the theory of the beam-coupling impedance for an axisymmetric two-dimensional structure, generalizing Zotter's theories, and a new general theory is derived for the impedance of an infinite flat two-dimensional structure. Then, a new approach has been found to compute the wake functions from such analytically obtained beam-coupling impedances, over-coming limitations that could be met with standard discrete Fourier transform procedures. Those results are then used to obtain an impedance and wake function model of the LHC, based on the (resistive-) wall im...

  2. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks | Center for Cancer Research

    Science.gov (United States)

    The purpose of this study was to develop a method of classifying cancers to specific diagnostic categories based on their gene expression signatures using artificial neural networks (ANNs). We trained the ANNs using the small, round blue-cell tumors (SRBCTs) as a model. These cancers belong to four distinct diagnostic categories and often present diagnostic dilemmas in clinical practice. The ANNs correctly classified all samples and identified the genes most relevant to the classification.

  3. Development of a high-speed digital signal process system for bunch-by-bunch feedback systems

    Directory of Open Access Journals (Sweden)

    Makoto Tobiyama

    2000-01-01

    Full Text Available High-speed digital filter systems for bunch-by-bunch feedback systems have been developed at KEK. A two-tap finite impulse response filter with simple hardware realizes the functions of a 90° phase shift, suppression of the static component and digital delay of up to a few hundred turns for the KEKB rings. Difficulties in the circuit board, such as the trimming of the timing skews or the problem of long-term reliability, have been solved using custom GaAs large-scale integrated circuits which demultiplex and multiplex fast parallel-digital data coming from the analog-to-digital converter and going to the digital-to-analog converter. Two major applications of the filter board, the bunch current monitor and the bunch oscillation recorder with 20 MB memories for transient-domain analysis of the instabilities, are also described.

  4. Reflective optical system for time-resolved electron bunch measurements at PITZ

    Energy Technology Data Exchange (ETDEWEB)

    Rosbach, K.; Baehr, J. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Roensch-Schulenburg, J. [Hamburg Univ. (Germany). Inst. fuer Experimentalphysik

    2011-01-15

    The Photo-Injector Test facility at DESY, Zeuthen site (PITZ), produces pulsed electron beams with low transverse emittance and is equipped with diagnostic devices for measuring various electron bunch properties, including the longitudinal and transverse electron phase space distributions. The longitudinal bunch structure is recorded using a streak camera located outside the accelerator tunnel, connected to the diagnostics in the beam-line stations by an optical system of about 30 m length. This system mainly consists of telescopes of achromatic lenses, which transport the light pulses and image them onto the entrance slit of the streak camera. Due to dispersion in the lenses, the temporal resolution degrades during transport. This article presents general considerations for time-resolving optical systems as well as simulations and measurements of specific candidate systems. It then describes the development of an imaging system based on mirror telescopes which will improve the temporal resolution, with an emphasis on off-axis parabolic mirror systems working at unit magnification. A hybrid system of lenses and mirrors will serve as a proof of principle. (orig.)

  5. Investigation of the phase space distribution of electron bunches at the FLASH-linac using a transverse deflecting structure

    Energy Technology Data Exchange (ETDEWEB)

    Roehrs, M.

    2008-06-15

    The operation of a high-gain free-electron laser (FEL) puts stringent demands on the peak current, transverse emittance and energy spread of the electron beam. At the Free Electron Laser in Hamburg (FLASH), a transverse deflecting structure (TDS) has been installed to investigate these electron beam parameters. The radio-frequency electromagnetic field in the TDS is utilized to deflect the beam electrons vertically as a function of time so that the charge distribution in the longitudinal-horizontal plane can be imaged with optical transition radiation screens. Using this technique, the single-bunch current profile was measured with an unprecedented resolution of about 10 {mu}m (30 fs) under FEL operating conditions. A precise single-shot measurement of the energy distribution along a bunch was accomplished by using the TDS in combination with an energy spectrometer. Appropriate variations of the focal strengths of quadrupole magnets allowed for the measurement of the horizontal emittance as a function of the longitudinal position within a bunch (slice emittance) with a longitudinal resolution in the order of 10 {mu}m. While the slice emittance in the peak current region was measured to be significantly larger than deduced from properties of the FEL radiation, tomographic methods revealed a bunch region of small horizontal emittance and high current. The observed increase in slice emittance in the peak current region was found to be caused by coherent emission of synchrotron radiation within bending magnets. (orig.)

  6. Longitudinal impedance monitoring in the SPS with single short bunches at 26 GeV/c (RF on)

    CERN Document Server

    Bohl, T; Shaposhnikova, E; CERN. Geneva. AB Department

    2008-01-01

    In the course of monitoring the low frequency impedance of the SPS over the years usually the quadrupole frequency shift as a function of intensity is measured with single bunches at 26 GeV/c with RF on using the peak detected signal. The additional acquisition of longitudinal bunch profiles allows the evaluation of various parameters of the injected beam, details of its quadrupole oscillation and the evolution of the bunch length as a function of time. Data acquired between 1999 and 2007 will be analysed in this respect. It will be shown that the bunch length data at 600 ms indicates clearly the effect of the SPS impedance reduction programme realised in 2000/2001 and that from then on the absolute value of the quadrupole frequency shift shows a tendency to increase over the years, indicating an impedance increase. However, it does not allow to monitor unambiguously the changes from one year to the next. The reason that the quadrupole frequency shift is not very well determined is attributed to the lack of r...

  7. Optimization of a train of bunches for plasma wakefield acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Martorelli, Roberto

    2016-05-10

    Particle accelerators are a fundamental instrument for the understanding of fundamental mechanism in nature. The need of always higher energies for the particle beams requires a huge increase of the sizes of the accelerators using the actual technology. Moreover the highest energies are achieved nowadays by circular colliders, not perfectly suitable for acceleration of electrons and positrons due to the radiation losses. In order to overcome this problem a new branch of physics studying alternative technique for particle acceleration has been developed. Among the various alternatives a promising one is the plasma wakefield acceleration (PWFA), in which a driver bunch interacts with a cold background plasma, exciting a plasma wave. The electric field of the plasma wave is then used for the acceleration of a second bunch. Such a mechanism allows to reach fields strength far beyond currently available, limited by the dielectric strength of the material. Among the different driver configurations, a promising one is the use of a modulated beam, namely a train of bunches, that provides a coherent interference among the electric fields generated by the single bunches. Such mechanism is subjected to a renewed interest in view of the forthcoming AWAKE experiment at CERN in which the long proton beam produced at the SPS facility is used as a driver. This possibility is achieved thanks to the onset of the self-modulation instability that modulates the long beam in a train of approximately 100 bunches. In order to accelerate the witness bunch to high energies is necessary on the other hand an efficient exchange of energy from the driver to the accelerated bunch, as well as a long duration of the driver so that can propagates for kilometers. This thesis deals with this two last aspects. The aim of this work is to provide an optimization for the modulated driver in order to improve specific features of the PWFA. This work shows the possibility to achieve an improved efficiency

  8. Real-time monitoring of longitudinal electron bunch parameters by intensity-integrated and spectroscopic measurements of single coherent THz pulses; Echtzeitbestimmung longitudinaler Elektronenstrahlparameter mittels absoluter Intensitaets- und Spektralmessung einzelner kohaerenter THz Strahlungspulse

    Energy Technology Data Exchange (ETDEWEB)

    Wesch, Stephan

    2012-12-15

    High-gain free-electron lasers (FELs) generate intense and monochromatic photon pulses with few tens of femtosecond duration. For this purpose, electron beams are accelerated to relativistic energies and shrunk longitudinally down to micrometer size.The diagnosis of theses compressed electron bunches is a challenge especially for MHz bunch repetition rates as provided by the FEL FLASH in Hamburg. In this thesis, coherently emitted THz radiation of single electron bunches were investigated, on which the longitudinal structure is imprinted. Two instruments were used: First, the FLASH bunch compression monitors, relying on the integrated intensity measurement of diffraction radiation, were modified to determine the overall length of every bunch behind the two bunch compressors (BC). A model was developed showing that their response is independent of the exact bunch shape for lengths below 200 {mu}m (rms). This could experimentally be verified in the range between 50 and 190 {mu}m within 7% accuracy for themonitor behind the last BC by comparison with measurements with the transverse deflecting structure (TDS). Second, a single-shot spectrometer with five staged reflective blazed gratings has been designed, build and commissioned. With its two grating sets, the wavelength ranges from 5.5 to 44 {mu}m and 45 to 440 {mu}m can be simultaneously detected by 118 fast pyroelectric elements. Measurements based on transition radiation spectra were compared with profiles recorded by the TDS.The shape of the spectra as well as the reconstructed temporal profiles (using the Kramers-Kronig relation for phase retrieval) are in excellent agreement. For bunches with a charge of 50 pC, bunch lengths down to 5 {mu}m (fhwm) could be detected.

  9. Ultrafast Diagnostics for Electron Beams from Laser Plasma Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Matlis, N. H.; Bakeman, M.; Geddes, C. G. R.; Gonsalves, T.; Lin, C.; Nakamura, K.; Osterhoff, J.; Plateau, G. R.; Schroeder, C. B.; Shiraishi, S.; Sokollik, T.; van Tilborg, J.; Toth, Cs.; Leemans, W. P.

    2010-06-01

    We present an overview of diagnostic techniques for measuring key parameters of electron bunches from Laser Plasma Accelerators (LPAs). The diagnostics presented here were chosen because they highlight the unique advantages (e.g., diverse forms of electromagnetic emission) and difficulties (e.g., shot-to-shot variability) associated with LPAs. Non destructiveness and high resolution (in space and time and energy) are key attributes that enable the formation of a comprehensive suite of simultaneous diagnostics which are necessary for the full characterization of the ultrashort, but highly-variable electron bunches from LPAs.

  10. Beam diagnostics measurements at 3 MeV of the LINAC4 H- beam at CERN

    CERN Document Server

    Zocca, F; Duraffourg, M; Focker, G J; Gerard, D; Kolad, B; Lenardon, F; Ludwig, M; Raich, U; Roncarolo, F; Sordet, M; Tan, J; Tassan-Viol, J; Vuitton, C; Feshenko, A

    2014-01-01

    As part of the CERN LHC injector chain upgrade, LINAC4 [1, 2] will accelerate H- ions to 160 MeV, replacing the old 50 MeV proton linac. The ion source, the Low Energy Beam Transfer (LEBT) line, the 3 MeV Radio Frequency Quadrupole and the Medium Energy Beam Transfer (MEBT) line hosting a chopper, have been commissioned in the LINAC4 tunnel. Diagnostic devices are installed in the LEBT and MEBT line and in a movable diagnostics test bench which is temporarily added to the MEBT exit. The paper gives an overview of all the instruments used, including beam current transformers, beam position monitors, wire scanners and wire grids for transverse profile measurements, a longitudinal bunch shape monitor and a slit-and-grid emittance meter. The instrumentation performance is discussed and the measurement results that allowed characterizing the 3 MeV beam in the LINAC4 tunnel are summarized.

  11. Diagnostics Beamline for the SRF Gun Project

    CERN Document Server

    Kamps, T; Goldammer, K; Krämer, Dietrich; Kuske, P; Kuszynski, J; Lipka, D; Marhauser, F; Quast, T; Richter, R

    2005-01-01

    A superconducting rf photo electron injector (SRF gun) is currently under construction by a collaboration between BESSY, DESY, FZR and MBI. The project aims at the design and setup of an CW SRF gun including a diagnostics beamline for the ELBE FEL and to address R&D issues on low emittance injectors for future light sources such as the BESSY FEL. Of critical importance for the injector performance is the control of the electron beam parameters. For this reason a compact diagnostics beamline is under development serving a multitude of operation settings ranging from low-charge (77pC), low-emittance (1 pi mm mrad) mode to high-charge (2.5nC) operation of the gun. For these operation modes beam dynamics simulations are resulting in boundary conditions for the beam instrumentation. Proven and mature technology is projected wherever possible, for example for current and beam position monitoring. The layout of the beam profile and emittance measurement systems is described. For the bunch length, which varies be...

  12. Step Bunching: Influence of Impurities and Solution Flow

    Science.gov (United States)

    Chernov, A. A.; Vekilov, P. G.; Coriell, S. R.; Murray, B. T.; McFadden, G. B.

    1999-01-01

    Step bunching results in striations even at relatively early stages of its development and in inclusions of mother liquor at the later stages. Therefore, eliminating step bunching is crucial for high crystal perfection. At least 5 major effects causing and influencing step bunching are known: (1) Basic morphological instability of stepped interfaces. It is caused by concentration gradient in the solution normal to the face and by the redistribution of solute tangentially to the interface which redistribution enhances occasional perturbations in step density due to various types of noise; (2) Aggravation of the above basic instability by solution flowing tangentially to the face in the same directions as the steps or stabilization of equidistant step train if these flows are antiparallel; (3) Enhanced bunching at supersaturation where step velocity v increases with relative supersaturation s much faster than linear. This v(s) dependence is believed to be associated with impurities. The impurities of which adsorption time is comparable with the time needed to deposit one lattice layer may also be responsible for bunching; (4) Very intensive solution flow stabilizes growing interface even at parallel solution and step flows; (5) Macrosteps were observed to nucleate at crystal corners and edges. Numerical simulation, assuming step-step interactions via surface diffusion also show that step bunching may be induced by random step nucleation at the facet edge and by discontinuity in the step density (a ridge) somewhere in the middle of a face. The corresponding bunching patterns produce the ones observed in experiment. The nature of step bunching generated at the corners and edges and by dislocation step sources, as well as the also relative importance and interrelations between mechanisms 1-5 is not clear, both from experimental and theoretical standpoints. Furthermore, several laws controlling the evolution of existing step bunches have been suggested, though

  13. Simple method for generating adjustable trains of picosecond electron bunches

    Directory of Open Access Journals (Sweden)

    P. Muggli

    2010-05-01

    Full Text Available A simple, passive method for producing an adjustable train of picosecond electron bunches is demonstrated. The key component of this method is an electron beam mask consisting of an array of parallel wires that selectively spoils the beam emittance. This mask is positioned in a high magnetic dispersion, low beta-function region of the beam line. The incoming electron beam striking the mask has a time/energy correlation that corresponds to a time/position correlation at the mask location. The mask pattern is transformed into a time pattern or train of bunches when the dispersion is brought back to zero downstream of the mask. Results are presented of a proof-of-principle experiment demonstrating this novel technique that was performed at the Brookhaven National Laboratory Accelerator Test Facility. This technique allows for easy tailoring of the bunch train for a particular application, including varying the bunch width and spacing, and enabling the generation of a trailing witness bunch.

  14. Minimizing Slope and Kick of Intermediate Bunches for Electron Cooling

    Science.gov (United States)

    Dotson, Andrew

    2017-09-01

    Ions in the Jefferson Lab Electron-Ion Collider (JLEIC) will have transverse energy, which limits the beams density. Electron cooling is a process by which a beam of bunched electrons with small transverse kinetic energy is directed along the ion beam with the same velocity. The ions transfer their transverse kinetic energy to the electron bunches, making the ions lose transverse energy. Electron bunches will be supplied by an electron gun. The required current needed to cool the ion beam can be reached by reusing electrons and incorporating RF kicker cavities to supply a pulsed electric field that kicks every 11th bunch out of the cooling ring. This provides an exact solution that yields zero kick and slope to all intermediate bunches in the cooling ring, which is described by a cosine series with 11 terms. The goal of this project is to determine if solutions exist that are sufficiently close to zero kick and slope, but require less than 4 kicker cavities. The method used to find these solutions is minimizing an objective function through Sequential Least Squares Programming (SLSQP). A Pareto front then demonstrated the average kick vs. average slope when using 1 through 4 kickers.

  15. Harmonically resonant cavity as a bunch-length monitor

    Directory of Open Access Journals (Sweden)

    B. Roberts

    2016-05-01

    Full Text Available A compact, harmonically resonant cavity with fundamental resonant frequency 1497 MHz was used to evaluate the temporal characteristics of electron bunches produced by a 130 kV dc high voltage spin-polarized photoelectron source at the Continuous Electron Beam Accelerator Facility (CEBAF photoinjector, delivered at 249.5 and 499 MHz repetition rates and ranging in width from 45 to 150 picoseconds (FWHM. A cavity antenna attached directly to a sampling oscilloscope detected the electron bunches as they passed through the cavity bore with a sensitivity of ∼1  mV/μA. The oscilloscope waveforms are a superposition of the harmonic modes excited by the beam, with each cavity mode representing a term of the Fourier series of the electron bunch train. Relatively straightforward post-processing of the waveforms provided a near-real time representation of the electron bunches revealing bunch-length and the relative phasing of interleaved beams. The noninvasive measurements from the harmonically resonant cavity were compared to measurements obtained using an invasive RF-deflector-cavity technique and to predictions from particle tracking simulations.

  16. Space-charge dynamics in ultra-cold ion bunches

    Science.gov (United States)

    Scholten, Robert; Murphy, Dene; Speirs, Rory; Thompson, Daniel; Sparkes, Benjamin; McCulloch, Andrew

    2014-05-01

    Cold ion sources based on photoionisation of laser cooled atoms provide a unique system for investigating Coulomb interactions within complex charged particle bunches. Space-charge driven expansion in charged particle beams is of critical importance for applications including electron and ion microscopy, mass spectrometry, synchrotrons and x-ray free electron lasers, and in electron diffraction where space-charge effects constrain the capacity to obtain diffraction information. Self-field effects are often difficult to observe because of thermal diffusion with traditional sources. Cold atom sources produce ions with temperatures of a few mK, such that subtle space-charge effects are apparent. We illustrate the capabilities through detailed investigation of a complex ion bunch shape, showing collective behaviour including high density caustics and shockwave structures arising from long-range interactions between small charge bunches.

  17. Single Bunch Longitudinal Instability in the CERN SPS

    CERN Document Server

    Lasheen, Alexandre; Hancock, Steven; Radvilas, Edgaras; Roggen, Toon; Shaposhnikova, Elena

    2016-01-01

    The longitudinal single bunch instability observed in the SPS leads to uncontrolled emittance blow-up and limits the quality of high intensity beams required for the High Luminosity LHC and AWAKE projects at CERN. The present SPS impedance model developed from a thorough survey of machine elements was used in macro-particle simulations (with the code BLonD) of the bunch behavior through the acceleration cycle. Comparison of simulations with measurements of the synchrotron frequency shift, performed on the SPS flat bottom to probe the impedance, show a reasonable agreement. During extensive experimental studies various beam and machine parameters (bunch intensity, longitudinal emittance, RF voltage, with single and double RF systems) were scanned in order to further benchmark the SPS impedance model with measurements and to better understand the mechanism behind the instability. It was found that the dependence of instability threshold on longitudinal emittance and beam energy has an unexpected non-monotonic b...

  18. Nonlinear bunch motion in an accelerator with reactive impedance

    CERN Document Server

    Shaposhnikova, Elena

    1996-01-01

    Closed form solutions have been found for single particle and bunch motion in an accelerator with reactive (space charge or inductive wall) impedance. The problem is solved for the particular initial longitudinal distribution corresponding to a parabolic line density. In the case with RF off the system of equations in phase space is the same as that describing motion of a body under a gravitational force with integrals of motion similar to Kepler's laws. With RF on this model allows the amplitude and frequency of coherent bunch shape oscillations to be calculated for a bunch of any intensity far away from equilibrium. The results have been used to estimate the low-frequency impedance of the CERN SPS.

  19. A waveguide overloaded cavity as longitudinal kicker for the DA{Phi}NE bunch-by-bunch feedback system

    Energy Technology Data Exchange (ETDEWEB)

    Gallo, A.; Boni, R.; Ghigo, A.; Marcellini, F.; Serio, M.; Zobov, M. [Instituto Nazionale de Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati

    1996-08-01

    The multibunch operation of DA{Phi}NE calls for a very efficient feedback system to damp the coupled-bunch longitudinal instabilities. A collaboration program among SLAC, LBL and LNF laboratories on this subject led to the development of a time domain, digital system based on digital signal processors that has been already successfully tested at ALS. The feedback chain ends with the longitudinal kicker, an electromagnetic structure capable of transferring the proper energy correction to each bunch. A cavity kicker for the DA{Phi}NE bunch-by-bunch longitudinal feedback system based on a pill-box loaded by six waveguides has been designed and a full-scale aluminium prototype has been fabricated at LNF. Both simulations and measurements have shown a peak shunt impedance of about 750 ohm and a bandwidth of about 220 MHz. The large shunt impedance allows to economize on the costly feedback power. Moreover, the damping waveguides drastically reduce the device HOM longitudinal and transverse impedances. One cavity pre ring will be sufficient to operate the machine up to 30 bunches while a second device per ring together with a feedback power improvement will be necessary to reach the ultimate current. (G.T.)

  20. Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients.

    Science.gov (United States)

    Verly, Iedan R N; van Kuilenburg, André B P; Abeling, Nico G G M; Goorden, Susan M I; Fiocco, Marta; Vaz, Frédéric M; van Noesel, Max M; Zwaan, C Michel; Kaspers, GertJan L; Merks, Johannes H M; Caron, Huib N; Tytgat, Godelieve A M

    2017-02-01

    Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths. Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are most commonly analysed in urine of NBL patients. However, their diagnostic sensitivity is suboptimal (82%). Therefore, we performed in-depth analysis of the diagnostic sensitivity of a panel of urinary catecholamine metabolites. Retrospective study of a panel of 8 urinary catecholamine metabolites (VMA, HVA, 3-methoxytyramine [3MT], dopamine, epinephrine, metanephrine, norepinephrine and normetanephrine [NMN]) from 301 NBL patients at diagnosis. Special attention was given to subgroups, metaiodobenzylguanidine (MIBG) non-avid tumours and VMA/HVA negative patients. Elevated catecholamine metabolites, especially 3MT, correlated with nine out of 12 NBL characteristics such as stage, age, MYCN amplification, loss of heterozygosity for 1p and bone-marrow invasion. The combination of the classical markers VMA and HVA had a diagnostic sensitivity of 84%. NMN was the most sensitive single diagnostic metabolite with overall sensitivity of 89%. When all 8 metabolites were combined, a diagnostic sensitivity of 95% was achieved. Among the VMA and HVA negative patients, were also 29% with stage 4 disease, which usually had elevation of other catecholamine metabolites (93%). Diagnostic sensitivity for patients with MIBG non-avid tumour was improved from 33% (VMA and/or HVA) to 89% by measuring the panel. Our study demonstrates that analysis of a urinary catecholamine metabolite panel, comprising 8 metabolites, ensures the highest sensitivity to diagnose NBL patients. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Electron bunch length measurement with a wakefield radiation decelerator

    Directory of Open Access Journals (Sweden)

    Weiwei Li

    2014-03-01

    Full Text Available In this paper, we propose a novel method to measure the electron bunch length with a dielectric wakefield radiation (DWR decelerator which is composed of two dielectric-lined waveguides (DLWs and an electron spectrometer. When an electron beam passes through a DLW, the DWR is excited which leads to an energy loss of the electron beam. The energy loss is found to be largely dependent on the electron bunch length and can be easily measured by an electron spectrometer which is essential for a normal accelerator facility. Our study shows that this method has a high resolution and a great simplicity.

  2. Optical plasma torch electron bunch generation in plasma wakefield accelerators

    Directory of Open Access Journals (Sweden)

    G. Wittig

    2015-08-01

    Full Text Available A novel, flexible method of witness electron bunch generation in plasma wakefield accelerators is described. A quasistationary plasma region is ignited by a focused laser pulse prior to the arrival of the plasma wave. This localized, shapeable optical plasma torch causes a strong distortion of the plasma blowout during passage of the electron driver bunch, leading to collective alteration of plasma electron trajectories and to controlled injection. This optically steered injection is more flexible and faster when compared to hydrodynamically controlled gas density transition injection methods.

  3. Gyrophase-bunched Electrons: Cluster Observations and Simulations

    Science.gov (United States)

    Gurgiolo, C.; Vinas, A. F.; Goldstein, Melvyn L.

    2003-01-01

    The interaction of the solar wind with the Earth's bow shock is responsible for a number of phenomena both upstream and downstream. One of the least understood and studied of these is the generation of gyrophase-bunched electrons. We will describe initial work searching for and analyzing such events in (Plasma Electron And Current Experiment (PEACE) data from CLUSTER. Plasma simulations will complement the data analysis. Recent analyses suggest that gyrophase-bunched electrons are present rather frequently in the upstream region, due either to energization in the reflection off the shock front or, more likely, to phase trapping in locally produced whistler wave fields.

  4. Measurements and analysis of a high-brightness electron beam collimated in a magnetic bunch compressor

    Directory of Open Access Journals (Sweden)

    F. Zhou

    2015-05-01

    Full Text Available A collimator located in a magnetic bunch compressor of a linear accelerator driven x-ray free electron laser has many potential applications, such as the removal of horns in the current distribution, the generation of ultrashort beams, and as a diagnostic of the beam slice emittance. Collective effects, however, are a major concern in applying the technique. Systematic measurements of emittance and analysis were performed using a collimator in the first bunch compressor of the Linac Coherent Light Source (LCLS. In the nominal, undercompressed configuration using the collimator we find that the y emittance (nonbending plane is not increased, and the x emittance (in the bending plane is increased by about 25%, in comparison to the injector emittance. From the analysis we conclude that the parasitic effects associated with this method are dominated by coherent synchrotron radiation (CSR, which causes a “systematic error” for measuring slice emittance at the bending plane using the collimation method. In general, we find good agreement between the measurements and simulations including CSR. However, for overcompressed beams at smaller collimator gaps, an extra emittance increase is found that does not agree with 1D simulations and is not understood.

  5. Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.

    Directory of Open Access Journals (Sweden)

    Guy Froyen

    Full Text Available The inevitable switch from standard molecular methods to next-generation sequencing for the molecular profiling of tumors is challenging for most diagnostic laboratories. However, fixed validation criteria for diagnostic accreditation are not in place because of the great variability in methods and aims. Here, we describe the validation of a custom panel of hotspots in 24 genes for the detection of somatic mutations in non-small cell lung carcinoma, colorectal carcinoma and malignant melanoma starting from FFPE sections, using 14, 36 and 5 cases, respectively. The targeted hotspots were selected for their present or future clinical relevance in solid tumor types. The target regions were enriched with the TruSeq approach starting from limited amounts of DNA. Cost effective sequencing of 12 pooled libraries was done using a micro flow cell on the MiSeq and subsequent data analysis with MiSeqReporter and VariantStudio. The entire workflow was diagnostically validated showing a robust performance with maximal sensitivity and specificity using as thresholds a variant allele frequency >5% and a minimal amplicon coverage of 300. We implemented this method through the analysis of 150 routine diagnostic samples and identified clinically relevant mutations in 16 genes including KRAS (32%, TP53 (32%, BRAF (12%, APC (11%, EGFR (8% and NRAS (5%. Importantly, the highest success rate was obtained when using also the low quality DNA samples. In conclusion, we provide a workflow for the validation of targeted NGS by a custom-designed pan-solid tumor panel in a molecular diagnostic lab and demonstrate its robustness in a clinical setting.

  6. Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer : A potential role for interleukin 7

    NARCIS (Netherlands)

    Lambeck, Annechien J. A.; Crijns, Anne P. G.; Leffers, Ninke; Sluiter, Wim J.; ten Hoor, Klaske A.; Braid, Mike; van der Zee, Ate G. J.; Daemen, Toos; Nijman, Hans W.; Kast, W. Martin

    2007-01-01

    Purpose: To evaluate if serum cytokine levels could be used as diagnostic or prognostic markers in ovarian cancer. Experimental Design: A cytokine bead array was done to simultaneously analyze 14 cytokines in the sera of 187 ovarian cancer patients with complete clinicopathologic data and follow-up,

  7. Multiple bunch longitudinal dynamics measurements at the Cornell Electron-Positron Storage Ring

    Directory of Open Access Journals (Sweden)

    R. Holtzapple

    2001-01-01

    Full Text Available The Cornell Electron-Positron Storage Ring (CESR has a longitudinal dipole-coupled-bunch instability that limits the total amount of current that can be stored in the ring without feedback. As a result, it is one of the major limitations for higher stored current and luminosity. This paper reports the measurements of multiple bunch longitudinal dynamics done on CESR with a streak camera. The camera was used to measure the dependence of the bunch distribution on current and accelerating rf voltage, for multiple bunches stored in CESR, as well as the effects of the longitudinal instability on the bunch distribution. Measurements of the beam's longitudinal bunch distribution with multiple bunches present in the ring help give an understanding of the instability, how it affects the bunch distribution, and possibly give insight into a cure of the instability.

  8. Space-charge effects in ultrahigh current electron bunches generated by laser-plasma accelerators

    National Research Council Canada - National Science Library

    Grüner, F. J; Schroeder, C. B; Maier, A. R; Becker, S; Mikhailova, J. M

    2009-01-01

    ...) generated in laser-plasma accelerators. At low electron energies such peak currents are expected to cause space-charge effects such as bunch expansion and induced energy variations along the bunch, potentially hindering the FEL process...

  9. Energy spread minimization in a cascaded laser wakefield accelerator via velocity bunching (Conference Presentation)

    Science.gov (United States)

    Zhang, Zhijun

    2017-05-01

    We report the observation of energy-spread compensation of electron bunches in a laser wakefield accelerator in experiment. The compensation was caused by the gradient wakefield in plasma wake, and the energy spectra of the bunches evolved during the acceleration so that we propose a new method to diagnose the longitudinal length of the ultrashort electron bunch. By analyzing the energy spectra of electron bunches with different acceleration length, the wakefield gradient difference and the wakefield slope of the bunch could be estimated by combining with the slippage between the plasma wave and the electron bunch, thus the electron bunches' longitudinal length could be estimated. By applying this new method, the longitudinal length of electron bunches with charge of about 40 pC generated from a laser wakefield accelerator was estimated to be (2.4 ± 2.2) μm in experiment, which was in good agreement with three-dimension particle-in-cell simulations.

  10. Acceleration of a trailing positron bunch in a plasma wakefield accelerator.

    Science.gov (United States)

    Doche, A; Beekman, C; Corde, S; Allen, J M; Clarke, C I; Frederico, J; Gessner, S J; Green, S Z; Hogan, M J; O'Shea, B; Yakimenko, V; An, W; Clayton, C E; Joshi, C; Marsh, K A; Mori, W B; Vafaei-Najafabadi, N; Litos, M D; Adli, E; Lindstrøm, C A; Lu, W

    2017-10-27

    High gradients of energy gain and high energy efficiency are necessary parameters for compact, cost-efficient and high-energy particle colliders. Plasma Wakefield Accelerators (PWFA) offer both, making them attractive candidates for next-generation colliders. In these devices, a charge-density plasma wave is excited by an ultra-relativistic bunch of charged particles (the drive bunch). The energy in the wave can be extracted by a second bunch (the trailing bunch), as this bunch propagates in the wake of the drive bunch. While a trailing electron bunch was accelerated in a plasma with more than a gigaelectronvolt of energy gain, accelerating a trailing positron bunch in a plasma is much more challenging as the plasma response can be asymmetric for positrons and electrons. We report the demonstration of the energy gain by a distinct trailing positron bunch in a plasma wakefield accelerator, spanning nonlinear to quasi-linear regimes, and unveil the beam loading process underlying the accelerator energy efficiency. A positron bunch is used to drive the plasma wake in the experiment, though the quasi-linear wake structure could as easily be formed by an electron bunch or a laser driver. The results thus mark the first acceleration of a distinct positron bunch in plasma-based particle accelerators.

  11. Ponderomotive scattering of an electron-bunch before injection into a laser wakefield

    NARCIS (Netherlands)

    Khachatryan, A.G.; Luttikhof, M.J.H.; van Goor, F.A.; Boller, Klaus J.

    2006-01-01

    For the purpose of laser wakefield acceleration, it turned out that also the injection of electron bunches longer than a plasma wavelength can generate accelerated femtosecond bunches with relatively low energy spread. This is of high interest because such injecting bunches can be provided, e.g., by

  12. First Commissioning Results of the ELETTRA Transverse Multi-Bunch Feedback

    CERN Document Server

    Bulfone, D; Bressanutti, R; Carniel, A; Cautero, G; Fabris, A; Gambitta, A; Giuressi, D; Loda, G; Lonza, M; Mazzolini, F; Mian, G; Pangos, N; Sergo, R; Smaluk, V; Tommasini, R; Tosi, L; Zambon, L

    2001-01-01

    A wide-band bunch-by-bunch Transverse Multi-Bunch Feedback, developed in collaboration with the Swiss Light Source (SLS), has been installed at ELETTRA. After a description of the main hardware/software components, the first commissioning results and the present status of the system are given.

  13. Multiple frequency generation by bunched solitons in Josephson tunnel junctions

    DEFF Research Database (Denmark)

    Lomdahl, P. S.; Sørensen, O. H.; Christiansen, Peter Leth

    1981-01-01

    A detailed numerical study of a long Josephson tunnel junction modeled by a perturbed sine-Gordon equation demonstrates the existence of a variety of bunched soliton configurations. Thus, on the third zero-field step of the V-I characteristic, two simultaneous adjacent frequencies are generated...

  14. Single Bunch Stability in LER of PEP II

    Energy Technology Data Exchange (ETDEWEB)

    Heifets, S.; /SLAC; Sabbi, G.; /Fermilab

    2011-10-11

    The note describes results of studies of the single bunch stability in the low energy ring (LER) of the PEP-II B-factory. Simulations describe the potential well distortion (PWD) obtained by numerical solution of the Haiisinski equation and results on the beam stability obtained with the code TRISIM. Both longitudinal and transverse wake fields are taken into account. Preliminary estimates indicate that single bunch in the LER of the PEP-II B-factory has to be stable, both longitudinally and transversely, at the maximum design bunch current 1.8 mA (beam current 3A). However, realistic wakes of the machine has been constructed only recently using results of the extensive numerical simulations of the vacuum components of the ring. Additional to that, the code TRISIM, a simulation program for single-bunch collective effects written by one of the authors (G. S.), became recently available. This allows us to study beam stability in a more reliable way than it is possible analytically.

  15. BUNCHED BEAM STOCHASTIC COOLING SIMULAITONS AND COMPARISON WITH DATA

    Energy Technology Data Exchange (ETDEWEB)

    BLASKIEWICZ,M.; BRENNAN, J.M.

    2007-09-10

    With the experimental success of longitudinal, bunched beam stochastic cooling in RHIC it is natural to ask whether the system works as well as it might and whether upgrades or new systems are warranted. A computer code, very similar to those used for multi-particle coherent instability simulations, has been written and is being used to address these questions.

  16. Analytical treatment of single bunch stability in a linac

    CERN Document Server

    Guignard, Gilbert

    1998-01-01

    Single bunch stability is analysed by solving the equation of motion of the particles travelling in a linac, for a Gaussian distribution of charge, a linear variation of the transverse wakefield along the bunch, a smooth focusing and negligible acceleration. The treatment is based on a non-standard perturbation expansion that has been specifically developed for this study and preserves at each order the intrinsic detuning likely to stabilise the resonant beam break-up. It provides a closed expression for the tune shift along the bunch resulting from BNS damping and autophasing, methods proposed in the past to control the emittance, and a first­order solution for the transverse off­sets within the bunch. The analytic result obtained makes it possible to study the behaviour of the solution and compute the emittance dilution in specific cases. The present theory is a useful complement to the numerical simulations done with the MUSTAFA code in the Compact Linear Collider scheme (CLIC). It also gives an interest...

  17. Palm oil fresh fruit bunch ripeness grading identification using color ...

    African Journals Online (AJOL)

    This research investigates the ripeness grading identification of the palm oil FFB using color features that are color histogram, color moment and color correlogram. Palm is harvested during the optimum stage of its ripeness since it improves the FFB oil quality and quantity. Harvesting wrong bunches decreases the oil ...

  18. Bunch Frequency Multiplication by RF Injection into an Isochronous Ring

    CERN Document Server

    Royer, P

    2003-01-01

    The Compact LInear Collider (CLIC)collaboration studies the possibility of building a multi-TeV (3 TeV centre-of-mass), high-luminosity electron-positron collider for particle physics. The CLIC scheme is based on high-frequency (30 GHz) linear accelerators powered by a low-energy, high-intensity drive beam running parallel to the main linear accelerators (Two-Beam Acceleration concept). One of the main challenges to realize this scheme is to generate the drive beam in a low-frequency accelerator and to achieve the required high-frequency bunch structure needed for the final acceleration. In order to provide bunch frequency multiplication, the main manipulation consists in sending the beam through an isochronous combiner ring using radio-frequency (RF) deflectors to inject and combine electron bunches. However, such a scheme has never been used before, and the first stage of the CLIC Test Facility 3 (CTF3) project aims at a low-charge demonstration of the bunch frequency multiplication by RF injection into an ...

  19. Effects of composted oil palm bunch wastes and chemical fertilizer ...

    African Journals Online (AJOL)

    A greenhouse study was conducted at the University of Nigeria, Nsukka to compare the effects of sole and integrated use of composted oil palm bunch waste and chemical fertilizer for improving the growth of oil palm seedlings under water stress condition. The experiment was a 3x3x4 factorial in a completely randomized ...

  20. Tax Bunching, Income Shifting and Self-employment

    DEFF Research Database (Denmark)

    le Maire, Christian Daniel; Schjerning, Bertel

    shifting was neglected in this case, we would conclude that taxable incomes were highly sensitive to changes in marginal tax rates. We show, however, that more than half of the observed bunching in taxable income for the self-employed is driven by intertemporal income shifting, implying a structural...

  1. LHC Report: 1,033 bunches per beam and counting

    CERN Multimedia

    Jorg Wenninger for the LHC team

    2015-01-01

    Following the second technical stop, the first beams were injected into the LHC in the early evening of Saturday, 5 September. About ten days later, the machine was operated with around 1,000 bunches per beam.    Evolution of the stored energy per LHC beam, over time.   The first step after a technical stop consists of running through a full LHC cycle, from injection to collisions and beam dump, with a low-intensity bunch (“probe”) to check all machine settings and equipment. This is followed by a series of collimation and absorber validation tests at different points in the LHC cycle. Low-intensity beams – typically the equivalent of three nominal bunches (3 x 1011 protons) – are expanded transversely or longitudinally, or de-bunched to verify that the collimators and absorbers are correctly intercepting lost particles. The techniques for those validations have been progressively improved, and t...

  2. Felling and bunching small timber on steep slopes.

    Science.gov (United States)

    Rodger A. Arola; Edwin S. Miyata; John A. Sturos; Helmuth M. Steinhilb

    1981-01-01

    Discusses the results of a field test of the unique Menzi Muck machine for felling and bunching small trees on steep slopes. Includes the analysis of a detailed time study to determine the productivity, costs, and economic feasibility of this unusual machine.

  3. String formulation of space charge forces in a deflecting bunch

    Directory of Open Access Journals (Sweden)

    Richard Talman

    2004-10-01

    Full Text Available The force between two moving point charges, because of its inverse square law singularity, cannot be applied directly in the numerical simulation of bunch dynamics; radiative effects make this especially true for short bunches being deflected by magnets. This paper describes a formalism circumventing this restriction in which the basic ingredient is the total force on a point charge comoving with a longitudinally aligned, uniformly charged string. Bunch evolution can then be treated using direct particle-to-particle, intrabeam scattering, with no need for an intermediate, particle-in-cell, step. Electric and magnetic fields do not appear individually in the theory. Since the basic formulas are both exact (in paraxial approximation and fully relativistic, they are applicable to beams of all particle types and all energies. But the theory is expected to be especially useful for calculating the emittance growth of the ultrashort electron bunches of current interest for energy recovery linacs and free-electron lasers. The theory subsumes coherent synchrotron radiation and centrifugal space charge force. Renormalized, on-axis, longitudinal field components are in excellent agreement with values from Saldin et al. [DESY Report No. DESY-TESLA-FEL-96-14, 1995; Nucl. Instrum. Methods Phys. Res., Sect. A 417, 158 (1998.NIMAER0168-900210.1016/S0168-9002(9800623-8

  4. Production of Mineral Water Using Palm Bunch Ash (PBA) From ...

    African Journals Online (AJOL)

    The composition of the palm bunch ash derived from oil palm Elaeis guineensis was determined and it was(PBA) found to contain potassium and magnesium in significant amounts. The ash solution was used to produce mineral water that has ionic composition comparable to those of some brands of bottled mineral water.

  5. Bacillus “next generation” diagnostics: moving from detection toward subtyping and risk-related strain profiling

    Science.gov (United States)

    Ehling-Schulz, Monika; Messelhäusser, Ute

    2013-01-01

    The highly heterogeneous genus Bacillus comprises the largest species group of endospore forming bacteria. Because of their ubiquitous nature, Bacillus spores can enter food production at several stages resulting in significant economic losses and posing a potential risk to consumers due the capacity of certain Bacillus strains for toxin production. In the past, food microbiological diagnostics was focused on the determination of species using conventional culture-based methods, which are still widely used. However, due to the extreme intra-species diversity found in the genus Bacillus, DNA-based identification and typing methods are gaining increasing importance in routine diagnostics. Several studies showed that certain characteristics are rather strain-dependent than species-specific. Therefore, the challenge for current and future Bacillus diagnostics is not only the efficient and accurate identification on species level but also the development of rapid methods to identify strains with specific characteristics (such as stress resistance or spoilage potential), trace contamination sources, and last but not least discriminate potential hazardous strains from non-toxic strains. PMID:23440299

  6. Investigations of Longitudinal Charge Distribution in Very Short Electron-Bunches

    CERN Document Server

    Hüning, M

    2001-01-01

    Electro-optical-sampling is a powerful technique to measure the longitudinal charge distribution of very short electron bunches. The electrical field moving with the bunch induces an optical an-isotropy in a ZnTe crystal which is probed by a polarized laser pulse. Two measurement principles are possible. In the first one a short laser pulse of lengths <50 fs is used directly to scan the time varying optical properties of the crystal. In the second method the laser pulse is frequency chirped and the temporal information is encoded into the time ordered frequency spectrum, which can be recovered by an optical grating and a CCD camera. A resolution in the 100 fs regime can also be achieved with longitudinal phase space tomography. Acceleration on the slope of the rf wave at different phases and measurements of the energy profiles are sufficient for a reconstruction algorithm based on maximum entropy methods. The longitudinal phase space distribution can be obtained without artifacts due to the limited angular...

  7. Loss Factor of Tapered Structures for Short Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Blednykh, A.

    2011-03-28

    Using the electromagnetic simulation code ECHO, we have found a simple phenomenological formula that accurately describes the loss factor for short bunches traversing an axisymmetric tapered collimator. In this paper, we consider tapered collimators with rectangular cross-section and use the GdfidL code to calculate the loss factor dependence on the geometric parameters for short bunches. The results for both axisymmetric and rectangular collimators are discussed. The behaviour of the impedance of tapered structures for very short bunches in the optical regime has been determined in refs. [10,11]. Here, for the loss factors for two particular geometries, we have studied the departure from the optical regime behaviour as bunch length is increased. In both cases, the ratio of the loss factor for the tapered collimator to the loss factor in the optical regime is a function only of the scaling parameter {sigma}L/d{sup 2}. The fact that the bunch length a and the taper length L appear as a product is consistent with the recent scaling derived by Stupakov in ref. [12], since there is only a weak dependence on g. One noteworthy fact that is not a priori expected is that only the larger radius or vertical half-aperture d appears. The reduction factor is independent of b. Moreover, it is striking that the specific form involving the arctan given in Eq. (5) holds for both geometries, with only the coefficient {mu} differing by a factor of {approx}2 for flat vs round. This suggests that there may be a useful phenomenological form for more general geometries which may follow from natural extensions of Eq. (5). This possibility is presently being investigated.

  8. Diagnostic Power of Broad Emission Line Profiles in Searches for Binary Supermassive Black Holes: Comparison of Models with Observations

    Science.gov (United States)

    Nguyen, Khai; Bogdanovic, Tamara; Eracleous, Michael; Runnoe, Jessie C.; Sigurdsson, Steinn

    2017-01-01

    Motivated by observational searches for sub-parsec supermassive black hole binaries (SBHBs) we develop a semi-analytic model to describe the spectral emission line signatures of these systems. We are particularly interested in modeling the profiles of the broad emission lines, which have been used as a tool to search for SBHBs. The goal of this work is to test one of the leading models of binary accretion flows in the literature: SBHB in a circumbinary disk. In this context, we model SBHB accretion flows as a set of three accretion disks: two mini-disks that are gravitationally bound to the individual black holes and a circumbinary disk that forms a common envelope about a gravitationally bound binary. Our first generation model shows that emission line profiles tend to have different statistical properties depending on the semi-major axis, mass ratio, eccentricity of the binary, and the alignment of the triple-disk system, and can in principle be used to constrain the statistical distribution of these parameters. We present the results of a second generation model, which improves upon the treatment of radiative transfer by taking into account the effect of line-driven winds on the properties of the model emission line profiles. This improvement allows a preliminary comparison of the model profiles with the observed SBHB candidates and AGN population in general.

  9. Application of Thomson scattering at 1.06{mu}m as a diagnostic for spatial profile measurements of electron temperature and density on the TCV tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Franke, S. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP)

    1997-04-01

    The variable configuration tokamak, TCV, in operation at CRPP since the end of 1991, is a particularly challenging machine with regard to the experimental system that must provide essential information regarding properties of confined plasmas with strongly shaped, non-circular cross-sections. The importance of the energy confinement issue in a machine designed specifically for the investigation of the effect of plasma shape on confinement and stability is self-evident, as is the necessity for a diagnostic capable of providing the profiles of electron temperature and density required for evaluation of this confinement. For TCV, a comprehensive Thomson Scattering (TS) diagnostic was the natural choice, specifically owing to the resulting spatially localized and time resolved measurement. The details of the system installed on TCV, together with the results obtained from the diagnostic comprise the subject matter of this thesis. A first version of the diagnostic was equipped with only ten observation volumes. In this case, adequate spatial resolution can only be maintained if measurements are limited to plasmas located in the upper half of the highly elongated TCV vacuum vessel. The system has recently been upgraded through the addition of a further fifteen observation volumes, together with major technical improvements in the scattered light detection system. This new version now permits TS observations in all TCV plasma configurations, including equilibria produced in the lower and upper halves of the vacuum vessel and the highly elongated plasmas now routinely created. Whilst a description of the new detection system along with some results obtained using the extended set of observation volumes are included, this thesis reports principally on the hardware details of and the interpretation of data from the original, ten observation volume system. (author) figs., tabs., 75 refs.

  10. Wakefield measurement using principal component analysis on bunch-by-bunch information during transient state of injection in a storage ring

    Directory of Open Access Journals (Sweden)

    Zhichu Chen

    2014-11-01

    Full Text Available Wakefields and beam instabilities are important issues for a storage ring and are described by various theoretical formalisms. Direct measurements of the beam motion related to different dynamical mechanisms are a useful input to accelerator optimization. This paper reports on an experimental method based on a simplified wakefield model, where bunch-by-bunch position information were monitored during the transient injection process at the Shanghai Synchrotron Radiation Facility. Processing the bunch-by-bunch data by means of the principal component analysis allowed for immediate operational improvements—such as in situ compensation of the kicker leakage, and energy matching between the booster and the storage ring.

  11. Bunch rotation tests at SPS flat top for the AWAKE experiment

    CERN Document Server

    Argyropoulos, T; Bohl, T; Esteban Müller, J F; Petrenko, A; Shaposhnikova, E; Timko, H

    2013-01-01

    This note summarises the results of two MDs on bunch rotation at SPS flat top. The first MD was carried out on 11th July 2012 with the Q26 optics, while the second MD on the 30th October 2012 used the Q20 optics. To obtain a short bunch length, which is important for the plasma wake-field acceleration project AWAKE, the bunches have been rotated in longitudinal phase space on the SPS flat top. The aim of the MDs was to obtain first estimates of what bunch length, intensity, and transverse emittances - which are crucial for the project - can be achieved for high-intensity single bunches.

  12. Short-bunch generation from an rf photoinjector with injection phase compensation

    Directory of Open Access Journals (Sweden)

    F. H. Chao

    2015-05-01

    Full Text Available A radio-frequency photoinjector is widely used for generating picosecond-femtosecond electron bunches. During particle acceleration, the electron bunch shape varies under the influence of both the acceleration fields and space charge fields. To restore a distorted electron bunch, we propose an injection phase compensation technique for the electrons by illuminating the photocathode with a pulse-front-corrected laser pulse. Using an S-band 1.6-cell photoinjector as an example, our study shows that the proposed technique can generate nearly undistorted electron bunches up to a bunch rate of a few hundred terahertz.

  13. Sequential control of step-bunching during graphene growth on SiC (0001)

    Energy Technology Data Exchange (ETDEWEB)

    Bao, Jianfeng; Kusunoki, Michiko [Institute of Materials and Systems for Sustainability, Nagoya University, Nagoya 464-8603 (Japan); Yasui, Osamu; Norimatsu, Wataru, E-mail: w-norimatsu@imass.nagoya-u.ac.jp; Matsuda, Keita [Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603 (Japan)

    2016-08-22

    We have investigated the relation between the step-bunching and graphene growth phenomena on an SiC substrate. We found that only a minimum amount of step-bunching occurred during the graphene growth process with a high heating rate. On the other hand, a large amount of step-bunching occurred using a slow heating process. These results indicated that we can control the degree of step-bunching during graphene growth by controlling the heating rate. We also found that graphene coverage suppressed step bunching, which is an effective methodology not only in the graphene technology but also in the SiC-based power electronics.

  14. Studies of bunch length and charge for the planned THz source, FLUTE

    Energy Technology Data Exchange (ETDEWEB)

    Naknaimueang, Somprasong [Karlsruhe Institute of Technology, Karlsruhe (Germany); Collaboration: FLUTE-Collaboration

    2013-07-01

    FLUTE is a THz source consisting of a 7 MeV photon gun, a 40 to 50 MeV linac, and a bunch compressor. The gun can produce up to 3 nC electron bunches which are several picoseconds long. At high charges, the transverse and longitudinal beam sizes are limited by space charge effects. In addition, coherent synchrotron radiation effects in the compressor limit the minimum obtainable bunch length in this case. The relationship between bunch charge and obtainable bunch length for a FLUTE-type accelerator is discussed.

  15. The Fine Structure of the Longitudinal Machine Impedance Observed with Single Bunches

    CERN Document Server

    Bohl, T; Shaposhnikova, Elena

    1998-01-01

    Using a beam spectrum measurement the detailed structure of the CERN SPS longitudinal machine impedance has been observed over a wide frequency range. Single high intensity proton bunches were injected into the machine with RF off. The spectrum of the unstable bunch modes, produced by the different resonant impedances in the ring, was measured during slow debunching. The maximum mode amplitude as a function of frequency was recorded for many injected bunches. The central frequency of each bunch mode is close to the resonant frequency of the impedance and the width depends upon the bunch length. Using sufficiently long bunches allowed the machine impedance to be seen in detail in the frequency range 100MHz to 4GHz. The low frequency of this range is defined by the initial stable bunch spectrum, and the high frequency by the vacuum chamber cut-off frequency. The dominant peaks in the spectrum have been identified with different impedance sources in the machine - some previously unknown.

  16. Creation and Storage of Long and Flat Bunches in the LHC

    CERN Document Server

    Damerau, H

    2005-01-01

    To maximize the luminosity of the Large Hadron Collider (LHC), the collision of particle bunches with a uniform longitudinal particle density is considered for a future upgrade. The benefits of such bunches and their generation by means of special longitudinal beam manipulations are presented in this report. Three possible options are analyzed with respect to their potential luminosity gain at the beam-beam limit: short rectangular bunches held by radio frequency (RF) harmonics using multiples of the nominal RF frequency of 400.8MHz, long and flat bunches held by multiples of 40.08MHz, and so-called superbunches, confined by barrier buckets. The comparison of the three different approaches shows that flat bunches, with an intermediate bunch length of the order of several meters, are capable of producing a comparable luminosity to superbunches, while avoiding most of their inherent disadvantages. Possible schemes to create the bunches with uniform line density are studied and a longitudinal manipulation to com...

  17. A prototype ionization profile monitor for RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, R.; Cameron, P.; Ryan, W. [and others

    1997-07-01

    Transverse beam profiles in the Relativistic Heavy-Ion Collider (RHIC) will be measured with ionization profile monitors (IPM`s). Each IPM collects and measures the distribution of electrons in the beamline resulting from residual gas ionization during bunch passage. The electrons are swept transversely from the beamline and collected on strip anodes oriented parallel to the beam axis. At each bunch passage the charge pulses are amplified, integrated, and digitized for display as a profile histogram. A prototype detector was tested in the injection line during the RHIC Sextant Test. This paper describes the detector and gives results from the beam tests.

  18. Pyrolysis of oil palm empty fruit bunch biomass pellets using multimode microwave irradiation.

    Science.gov (United States)

    Salema, Arshad Adam; Ani, Farid Nasir

    2012-12-01

    Oil palm empty fruit bunch pellets were subjected to pyrolysis in a multimode microwave (MW) system (1 kW and 2.45 GHz frequency) with and without the MW absorber, activated carbon. The ratio of biomass to MW absorber not only affected the temperature profiles of the EFB but also pyrolysis products such as bio-oil, char, and gas. The highest bio-oil yield of about 21 wt.% was obtained with 25% MW absorber. The bio-oil consisted of phenolic compounds of about 60-70 area% as detected by GC-MS and confirmed by FT-IR analysis. Ball lightning (plasma arc) occurred due to residual palm oil in the EFB biomass without using an MW absorber. The bio-char can be utilized as potential alternative fuel because of its heating value (25 MJ/kg). Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Distinguishing predictive profiles for patient-based risk assessment and diagnostics of plaque induced, surgically and prosthetically triggered peri-implantitis.

    Science.gov (United States)

    Canullo, Luigi; Tallarico, Marco; Radovanovic, Sandro; Delibasic, Boris; Covani, Ugo; Rakic, Mia

    2016-10-01

    To investigate whether specific predictive profiles for patient-based risk assessment/diagnostics can be applied in different subtypes of peri-implantitis. This study included patients with at least two implants (one or more presenting signs of peri-implantitis). Anamnestic, clinical, and implant-related parameters were collected and scored into a single database. Dental implant was chosen as the unit of analysis, and a complete screening protocol was established. The implants affected by peri-implantitis were then clustered into three subtypes in relation to the identified triggering factor: purely plaque-induced or prosthetically or surgically triggered peri-implantitis. Statistical analyses were performed to compare the characteristics and risk factors between peri-implantitis and healthy implants, as well as to compare clinical parameters and distribution of risk factors between plaque, prosthetically and surgically triggered peri-implantitis. The predictive profiles for subtypes of peri-implantitis were estimated using data mining tools including regression methods and C4.5 decision trees. A total of 926 patients previously treated with 2812 dental implants were screened for eligibility. Fifty-six patients (6.04%) with 332 implants (4.44%) met the study criteria. Data from 125 peri-implantitis and 207 healthy implants were therefore analyzed and included in the statistical analysis. Within peri-implantitis group, 51 were classified as surgically triggered (40.8%), 38 as prosthetically triggered (30.4%), and 36 as plaque-induced (28.8%) peri-implantitis. For peri-implantitis, 51 were associated with surgical risk factor (40.8%), 38 with prosthetic risk factor (30.4%), 36 with purely plaque-induced risk factor (28.8%). The variables identified as predictors of peri-implantitis were female sex (OR = 1.60), malpositioning (OR = 48.2), overloading (OR = 18.70), and bone reconstruction (OR = 2.35). The predictive model showed 82.35% of accuracy and

  20. Diagnostic system to measure spatial and temporal profiles of shock front using compact two-stage light-gas gun and line reflection method.

    Science.gov (United States)

    Yokoo, Manabu; Kawai, Nobuaki; Hironaka, Yoichiro; Nakamura, Kazutaka G; Kondo, Ken-Ichi

    2007-04-01

    A diagnostic system has been developed to obtain spatial and temporal profiles of shock front. A two-stage light-gas gun is used to accelerate impactors in velocity range with 4-9 km/s. The system consists of the Faraday-type electromagnetic sensors to measure impactor velocity, optical system with high-speed streak camera to measure shock-wave velocities, and the delay trigger system with self-adjustable pre-event pulse generator. We describe the specifications and performance of this system and data-analysis technique on the tilt and distortion of the shock front. Finally, we obtained the Hugoniot data of copper for system demonstration.

  1. Loss factor for short bunches in azimuthally symmetric tapered structures

    Directory of Open Access Journals (Sweden)

    A. Blednykh

    2010-06-01

    Full Text Available We use the program ECHO to study numerically the loss factor of axisymmetric cavities and collimators with and without tapering. We consider a Gaussian driving bunch of length σ, and structures with inner radius b, outer radius d, cavity gap (or collimator inner length g, and taper length L. In all cases we consider a short bunch with σ≪b. For the untapered structures (L=0, in certain regimes, we describe our numerical results using the known expressions for a step transition and for the diffraction model. In addition, we identify new regimes where gb, we present a phenomenological formula which accurately describes the dependence of the loss factor on the parameters σ, b, d, and L. This formula also holds for a tapered cavity with g>d^{2}/σ and d-b>b.

  2. Emittance preservation during bunch compression with a magnetized beam

    Energy Technology Data Exchange (ETDEWEB)

    Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-02

    The deleterious effects of coherent synchrotron radiation (CSR) on the phase-space and energy spread of high-energy beams in accelerator light sources can significantly constrain the machine design and performance. In this paper, we present a simple method to preserve the beam emittance by means of using magnetized beams that exhibit a large aspect ratio on their transverse dimensions. The concept is based on combining a finite solenoid field where the beam is generated together with a special optics adapter. Numerical simulations of this new type of beam source show that the induced phase-space density growth can be notably suppressed to less than 1% for any bunch charge. This work elucidates the key parameters that are needed for emittance preservation, such as the required field and aspect ratio for a given bunch charge.

  3. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  4. Compensating tune spread induced by space charge in bunched beams

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko, V.; Wang, G.

    2015-05-03

    The effects of space charge play a significant role in modern-day accelerators, frequently constraining the beam parameters attainable in an accelerator or in an accelerator chain. They also can limit the luminosity of hadron colliders operating either at low energies or with sub-TeV high-brightness hadron beams. The latter is applied for strongly cooled proton and ion beams in eRHIC – the proposed future electron-ion collider at Brookhaven National Laboratory. Using an appropriate electron beam would compensate both the tune shift and the tune spread in the hadron beam in a coasting beam. But these methods cannot compensate space charge tune spread in a bunched hadron beam. In this paper we propose and evaluate a novel idea of using a co-propagating electron bunch with mismatched longitudinal velocity to compensate the space charge induced tune-shift and tune spread.

  5. Longitudinal coupled-bunch instability studies in the PS

    CERN Document Server

    Damerau, H

    2017-01-01

    The main longitudinal limitation for LHC-type beams inthe PS are coupled-bunch instabilities. A dedicated proto-typefeedbacksystemusingaFinemetcavityasalongitudinalkicker has been installed. Extensive tests with beam havebeen performed to explore the intensity reach with this feed-back. The maximum intensity with nominal longitudinalemittance at PS extraction has been measured, as well as theemittance required to keep the beam longitudinally stableat the design intensity for the High-Luminosity LHC (HL-LHC). A higher-harmonic cavity is a complementary op-tion to extend the intensity reach beyond the capabilities ofthe coupled-bunch feedback. Preliminary machine develop-ment (MD) studies operating one20MHzor one40MHzRF system as a higher harmonic at the flat-top indicate thebeneficial effect on longitudinal beam stability

  6. Higher-order photon bunching in a semiconductor microcavity

    DEFF Research Database (Denmark)

    Assmann, M.; Veit, F.; Bayer, M.

    2009-01-01

    Quantum mechanically indistinguishable particles such as photons may show collective behavior. Therefore, an appropriate description of a light field must consider the properties of an assembly of photons instead of independent particles. We have studied multiphoton correlations up to fourth order...... in the single-mode emission of a semiconductor microcavity in the weak and strong coupling regimes. The counting statistics of single photons were recorded with picosecond time resolution, allowing quantitative measurement of the few-photon bunching inside light pulses. Our results show bunching behavior...... in the strong coupling case, which vanishes in the weak coupling regime as the cavity starts lasing. In particular, we verify the n factorial prediction for the zero-delay correlation function of n thermal light photons....

  7. Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples

    Directory of Open Access Journals (Sweden)

    Larissa Belov

    2016-04-01

    Full Text Available Extracellular vesicles (EV are membranous particles (30–1,000 nm in diameter secreted by cells. Important biological functions have been attributed to 2 subsets of EV, the exosomes (bud from endosomal membranes and the microvesicles (MV; bud from plasma membranes. Since both types of particles contain surface proteins derived from their cell of origin, their detection in blood may enable diagnosis and prognosis of disease. We have used an antibody microarray (DotScan to compare the surface protein profiles of live cancer cells with those of their EV, based on their binding patterns to immobilized antibodies. Initially, EV derived from the cancer cell lines, LIM1215 (colorectal cancer and MEC1 (B-cell chronic lymphocytic leukaemia; CLL, were used for assay optimization. Biotinylated antibodies specific for EpCAM (CD326 and CD19, respectively, were used to detect captured particles by enhanced chemiluminescence. Subsequently, this approach was used to profile CD19+ EV from the plasma of CLL patients. These EV expressed a subset (~40% of the proteins detected on CLL cells from the same patients: moderate or high levels of CD5, CD19, CD31, CD44, CD55, CD62L, CD82, HLA-A,B,C, HLA-DR; low levels of CD21, CD49c, CD63. None of these proteins was detected on EV from the plasma of age- and gender-matched healthy individuals.

  8. Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus.

    Science.gov (United States)

    Dittrich, Sabine; Tadesse, Birkneh Tilahun; Moussy, Francis; Chua, Arlene; Zorzet, Anna; Tängdén, Thomas; Dolinger, David L; Page, Anne-Laure; Crump, John A; D'Acremont, Valerie; Bassat, Quique; Lubell, Yoel; Newton, Paul N; Heinrich, Norbert; Rodwell, Timothy J; González, Iveth J

    2016-01-01

    Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities. In the absence of microbiology facilities in low-income settings, an assay to distinguish bacterial from non-bacterial causes would be a critical first step. To ensure that patient and market needs are met, the requirements of such a test should be specified in a target product profile (TPP). To identify minimal/optimal characteristics for a bacterial vs. non-bacterial fever test, experts from academia and international organizations with expertise in infectious diseases, diagnostic test development, laboratory medicine, global health, and health economics were convened. Proposed TPPs were reviewed by this working group, and consensus characteristics were defined. The working group defined non-severely ill, non-malaria infected children as the target population for the desired assay. To provide access to the most patients, the test should be deployable to community health centers and informal health settings, and staff should require 90% and >80% for sensitivity and specificity, respectively. Other key characteristics, to account for the challenging environment at which the test is targeted, included: i) time-to-result vs. non-bacterial assay should guide product development, and enable targeted and timely efforts by industry partners and academic institutions.

  9. Effective composting of empty fruit bunches using potential Trichoderma strains

    OpenAIRE

    Shafiquzzaman Siddiquee; Saili Nur Shafawati; Laila Naher

    2017-01-01

    Oil palm fibres are easy to degrade, eco-friendly in nature and once composted, they can be categorized under nutrient-enriched biocompost. Biocompost is not only a good biofertilizer but also a good biocontrol agent against soil-borne pathogens. In this research, experimental works on the composting of empty fruit bunches (EFB) from the oil palm industry were conducted using two potential Trichoderma strains. Analysis of pH initially found the soils to be slightly acidic. However, after comp...

  10. Bunch lengthening with bifurcation in electron storage rings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun-San; Hirata, Kohji [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1996-08-01

    The mapping which shows equilibrium particle distribution in synchrotron phase space for electron storage rings is discussed with respect to some localized constant wake function based on the Gaussian approximation. This mapping shows multi-periodic states as well as double bifurcation in dynamical states of the equilibrium bunch length. When moving around parameter space, the system shows a transition/bifurcation which is not always reversible. These results derived by mapping are confirmed by multiparticle tracking. (author)

  11. Flat Bunches with a Hollow Distribution for Space Charge Mitigation

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni

    2016-01-01

    Longitudinally hollow bunches provide one means to mitigate the impact of transverse space charge. The hollow distributions are created via dipolar parametric excitation during acceleration in CERN's Proton Synchrotron Booster. We present simulation work and beam measurements. Particular emphasis is given to the alleviation of space charge effects on the long injection plateau of the downstream Proton Synchrotron machine, which is the main goal of this study.

  12. Creation of Hollow Bunches using a Double Harmonic RF system

    CERN Document Server

    Carli, Christian

    2001-01-01

    The main motivation for the creation of hollow bunches in the PSB is to increase the bunching factor at transfer to the PS. Due to the reduction of the peak current and direct transverse space charge forces, one expects less blow up and losses at low energy in the PS. Thus, it does not matter when the hollow distribution in longitudinal phase space is created in the PSB cycle. We propose methods involving the h=1 and h=2 RF systems available in the PSB. The first method is based on controlled blow up by recombination of the bunch in one bucket, with another empty bucket. By appropriate adjustment of the phase between the two RF systems, more empty phase space can be inserted close to the centre creating a hollow distribution. The second method is based on a redistribution of phase space. The beam is transferred from one h=2 sub-bucket to the other and, during that process, regions from the centre with high density and from the periphery are exchanged. Simulations of both methods, based on tracking of particle...

  13. LHC Report: Boost in bunches brings record luminosity

    CERN Multimedia

    2011-01-01

    Having hit a luminosity of around 8.4x1032 cm-2 s-1 with 768 bunches per beam, the LHC went into a 5-day machine development (MD) program on Wednesday 4 May. Operators are now working on increasing the number of particle bunches in the machine towards a 2011 maximum of around 1380 bunches. The team is already hitting major milestones, recording another record-breaking peak luminosity on Monday 23 May.   Former LHC Project Leader Lyn Evans (to the right) and Laurette Ponce, the engineer-in-charge when the recent luminosity record was achieved. The MD periods improve our understanding of the machine, with the aim of increasing its short- and long-term performance. This one also included tests of the machine’s configurations for special physics runs and a future high luminosity LHC. It was an intense program and overall it went very well, with most measurements carried out successfully. Highlights included: commissioning a dedicated machine setup for TOTEM and ALFA; succe...

  14. Advanced beam dynamics and diagnostics concepts for laser-plasma accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Dornmair, Irene

    2017-05-15

    Laser-Plasma Accelerators (LPAs) combine a multitude of unique features, which makes them very attractive as drivers for next generation brilliant light sources including compact X-ray free-electron lasers. They provide high accelerating gradients, thereby drastically shrinking the accelerator size, while at the same time the produced electron bunches are intrinsically as short as a few femtoseconds and carry high peak currents. LPA are subject of very active research, yet, the field currently faces the challenge of improving the beam quality, and achieving stable and well-controlled injection and acceleration. This thesis tackles this issue from three different sides. A novellongitudinal phase space diagnostics is proposed that employs the strong fields present in plasma wakefields to streak ultrashort electron bunches. This allows for a temporal resolution down to the attosecond range, enabling direct determination to the current profile and the slice energy spread, both crucial quantities for the performance of free-electron lasers. Furthermore, adiabatic matching sections at the plasma-vacuum boundary are investigated. These can drastically reduce the beam divergence and thereby relax the constraints on the subsequent beam optics. For externally injected beams, the matching sections could even provide the key technology that permits emittance conservation by increasing the matched beam size to a level achievable with currently available magnetic optics. Finally, a new method is studied that allows to modify the wakefield shape. To this end, the plasma density is periodically modulated. One possible application can be to remove the linearly correlated energy spread, or chirp, from the accelerated bunch, which is suspected of being responsible for the main part of the often large energy spread of plasma accelerated beams.

  15. Diagnostic Role of MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome.

    Science.gov (United States)

    Karaca, Emin; Aykut, Ayça; Ertürk, Biray; Durmaz, Burak; Güler, Ahmet; Büke, Barış; Yeniel, Ahmet Özgür; Ergenoğlu, Ahmet Mete; Özkınay, Ferda; Özeren, Mehmet; Kazandı, Mert; Akercan, Fuat; Sağol, Sermet; Gündüz, Cumhur; Çoğulu, Özgür

    2017-12-08

    Down syndrome is the most common chromosomal anomaly in humans. Down syndrome is the most common chromosomal anomaly in humans affecting people from every race and age. Most of the cases are can be diagnosed by prenatal diagnostic methods in pregnancy. Due to the longtime of culture method applied for prenatal diagnosis, genetic analysis has been developed and developing for rapid diagnosis. For this reason, the effective use of miRNAs was investigated in the rapid analysis of prenatal samples with Down syndrome. We evaluated the expression levels of 14 miRNAs, located on chromosome 21 in prenatal samples and their utility for prenatal testing of Down syndrome. Case-control study. A total of 56 patients who underwent invasive prenatal testing, 23 carrying fetuses with DS; 33 control cases carrying fetuses with normal karyotype, were included. Indications for invasive prenatal testing were advanced maternal age and increased risk of Down syndrome in screening tests. Gestation weeks ranged between 17-18 in study and control groups. MicroRNA expression levels were measured by real-time-polymerase chain reaction. miR-125b-2, miR-155 and miR-3156 expression levels were significantly higher in prenatal samples. Significantly dysregulated miRNAs either may be associated with the phenotype or may be the result of abnormal development. Further large scale comparative studies carried out in a variety of conditions may bring novel insights in the field of abnormal conditions.

  16. Design of a Multi-Bunch BPM for the Next Linear Collider

    CERN Document Server

    Young, A

    2001-01-01

    The Next Linear Collider (NLC) design requires precise control of colliding trains of high-intensity (1.4 x 10 sup 1 sup 0 particles/bunch) and low-emittance beams. High-resolution multi-bunch beam position monitors (BPMs) are required to ensure uniformity across the bunch trains with bunch spacing of 1.4ns. A high bandwidth (approx 350 MHz) multi-bunch BPM has been designed based on a custom-made stripline sum and difference hybrid on a Teflon-based material. High bandwidth RF couplers were included to allow injection of a calibration tone. Three prototype BPMs were fabricated at SLAC and tested in the Accelerator Test Facility at KEK and in the PEP-II ring at SLAC. Tone calibration data and single-bunch and multi-bunch beam data were taken with high-speed (5Gsa/s) digitizers. Offline analysis determined the deconvolution of individual bunches in the multi-bunch mode by using the measured single bunch response. The results of these measurements are presented in this paper.

  17. Study of Single and Coupled-Bunch Instabilities for NSLS-II

    Energy Technology Data Exchange (ETDEWEB)

    Bassi, G.; Blednykh, A.

    2011-03-28

    We study single and coupled-bunch instabilities for the NSLS-II storage ring with a recently developed parallel tracking code. For accurate modelling of the coupled-bunch instability, we investigate improvements to current point-bunch models to take into account finite bunch-size effects. Accurate modelling of single and coupled-bunch instabilities is of crucial importance for the machine performance of light sources such as NSLS-II, that provide high current beams. The complexity of the model consists in the accurate calculation of the impedance of the various components of the ring that can excite single and multibunch instabilities via short and long range wakefields. Moreover, a full account of the coupling between transverse and longitudinal dynamics must be taken into account to study effects such as chromaticity and Landau cavity effects. A parallel algorithm for the study of single and coupled-bunch instabilities has been implemented in a particle tracking code. The theoretical framework for single bunch instabilities is the same used in the code TRANFT, while for coupled-bunch instabilities a self-consistent algorithm has been implemented to allow the study of finite bunch-size effects and multibunch effects in arbitrary filling modes. In this paper we present numerical studies of the microwave instability for NSLS-II and discuss the self-consistent algorithm for simulation of coupled-bunch instabilities.

  18. LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

    CERN Document Server

    AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

    2017-01-01

    The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

  19. Fast Faraday cup to measure neutralized drift compression in intense ion charge bunches

    Directory of Open Access Journals (Sweden)

    A. B. Sefkow

    2006-05-01

    Full Text Available Heavy ion drivers for heavy ion fusion and high energy density physics applications use space-charge-dominated ion beams which must undergo longitudinal bunch compression in order to meet the requisite beam intensities desired at the target. The Neutralized Drift Compression Experiment-1A (NDCX-1A at Lawrence Berkeley National Laboratory is used to determine the effective limits of neutralized drift compression, which occurs due to an imposed longitudinal velocity tilt on the drifting beam and subsequent neutralization of the beam’s space charge with background plasma. The accurate and temporally resolved measurement of the ion beam’s current and pulse length, which has been longitudinally compressed to a few nanoseconds duration at its focal plane, is a critical diagnostic. This paper describes the design and experimental results for a fast and accurate ion beam probe, which reliably measures the absolute beam current in the presence of high density plasma at the focal plane as a function of time. A particle-in-cell code has been used to model the propagation of the intense ion beam and to design the diagnostic probe.

  20. Diagnostic and Prognostic Significance of Lipid Profiles in Holstein Dairy Cattle with Displaced Abomasum: Before and After Surgical Operation

    Directory of Open Access Journals (Sweden)

    Arafat Khalphallah

    2016-01-01

    Full Text Available The study aimed to describe the pattern of changes in clinical findings and lipid metabolism profiles in dairy cattle with displacement of the abomasum (DA from day 0 until day 30 after operation. The study was conducted on DA cattle (n= 25 belonged to dairy farms in Hokkaido area, Japan. Cows were examined and sampled at days 0 (operation, 7 and 30. They were clinically and biochemically examined to estimate BCS and many serum biochemical constituents such as lecithin:cholesterol acyltransferase (LCAT and apolipoprotein B-100 (apoB-100, β-hydroxybutyric acid (BHBA, non-esterified fatty acids (NEFAs and aspartate amino transferase (AST. Based on blood BHBA at day 0, DA cows were classified into three categories; DA only (<1.2 mmol/l, DA with subclinical ketosis (DA SCK (1.2-2.4 mmol/l and DA with clinical ketosis (DA CK (≥2.5 mmol/l. The changes in the pattern of serum biochemical constituents throughout this study indicated recovery of diseased cows and significant effect of surgical operation. Serum biochemical constituents returned to their physiological values indicating that these cows were restoring their normal physiological status. This was reflected through a significant (P<0.05 elevation of LCAT, apoB-100, and cholesterol and a significant (P<0.05 reduction in AST, NEFAs and BHBA (Not in DA group, in all DA groups particularly at day 30 when their values compared with those at day 0. The current study also recorded no remarkable changes (P>0.05 between the diseased groups except for NEFA and BHBA (at day 0 between DA group and the other two groups at any of the three sampling days.

  1. Target Product Profile for a Diagnostic Assay to Differentiate between Bacterial and Non-Bacterial Infections and Reduce Antimicrobial Overuse in Resource-Limited Settings: An Expert Consensus.

    Directory of Open Access Journals (Sweden)

    Sabine Dittrich

    Full Text Available Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities. In the absence of microbiology facilities in low-income settings, an assay to distinguish bacterial from non-bacterial causes would be a critical first step. To ensure that patient and market needs are met, the requirements of such a test should be specified in a target product profile (TPP. To identify minimal/optimal characteristics for a bacterial vs. non-bacterial fever test, experts from academia and international organizations with expertise in infectious diseases, diagnostic test development, laboratory medicine, global health, and health economics were convened. Proposed TPPs were reviewed by this working group, and consensus characteristics were defined. The working group defined non-severely ill, non-malaria infected children as the target population for the desired assay. To provide access to the most patients, the test should be deployable to community health centers and informal health settings, and staff should require 90% and >80% for sensitivity and specificity, respectively. Other key characteristics, to account for the challenging environment at which the test is targeted, included: i time-to-result <10 min (but maximally <2 hrs; ii storage conditions at 0-40°C, ≤90% non-condensing humidity with a minimal shelf life of 12 months; iii operational conditions of 5-40°C, ≤90% non-condensing humidity; and iv minimal sample collection needs (50-100μL, capillary blood. This expert approach to define assay requirements for a bacterial vs. non-bacterial assay should guide product development, and enable targeted and timely efforts by industry partners and academic institutions.

  2. Clinico-epidemiological profile and diagnostic procedures of pediatric tuberculosis in a tertiary care hospital of western Nepal-a case-series analysis

    Directory of Open Access Journals (Sweden)

    Shah Ravi K

    2010-08-01

    Full Text Available Abstract Background Changing epidemiology and diagnostic difficulties of paediatric tuberculosis (TB are being increasingly reported. Our aim was to describe clinico-epidemiological profile and diagnostic procedures used for paediatric TB. Methods A retrospective case-series analysis was carried out in a tertiary care teaching hospital of western Nepal. All pediatric TB (age 0-14 years patients registered in DOTS clinic during the time period from March, 2003 to July, 2008 were included. Medical case files were reviewed for information on demography, clinical findings, investigations and final diagnosis. Analysis was done on SPSS package. Results were expressed as rates and proportions. Chi square test was used to test for statistical significance. Results About 17.2% (162/941 of TB patients were children. Common symptoms were cough, fever and lymph node swelling. The types of TB were pulmonary TB (46.3%, 75/162, followed by extra-pulmonary TB (41.4%, 67/162. Twelve patients (7.4% had disseminated TB. Distribution of types of TB according to gender was similar. PTB was common in younger age than EPTB which was statistically significant. EPTB was mainly localized to lymph node (38, 50.7%, and abdomen (9, 12%. Five main investigations namely Mantoux test, BCG test, chest radiograph, erythrocyte sedimentation rate (ESR and fine needle aspiration cytology (FNAC or biopsy were carried out to diagnose TB. Conclusions Paediatric TB in both pulmonary and extrapulmonary forms is a common occurrence in our setting. Age incidence according to type of TB was significant. Diagnosis was based on a combination of epidemiological and clinical suspicion supported by results of various investigations.

  3. Transverse multibunch modes for non-rigid bunches, including mode coupling

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J.S.; Ruth, R.D. [Stanford Linear Accelerator Center, Menlo Park, CA (United States)

    1996-08-01

    A method for computing transverse multibunch growth rates and frequency shifts in rings, which has been described previously, is applied to the PEP-II B factory. The method allows multibunch modes with different internal-bunch oscillation modes to couple to one another, similar to single-bunch mode coupling. Including coupling between the multibunch modes gives effects similar to those seen in single-bunch mode coupling. These effects occur at currents that are lower than the single-bunch mode coupling threshold. (author)

  4. Density of bunches of native bluebunch wheatgrass and alien crested wheatgrass

    Energy Technology Data Exchange (ETDEWEB)

    Rickard, W.H.

    1985-10-01

    The density of bunches of bluebunch wheatgrass in a natural undisturbed stand averaged 3.28 per m/sup 2/ as compared to 2.96 per m/sup 2/ for a nearby stand of crested wheatgrass that was planted 30 years ago. Bunch density was similar in both stands indicating that spacing is a response to an environment deficient in soil water. Bunches of crested wheatgrass on the average weighed 3.5 times more than bunches of bluebunch wheatgrass and they also produced a greater weight of seedheads.

  5. Single bunch longitudinal measurements at the Cornell Electron-Positron Storage Ring

    Directory of Open Access Journals (Sweden)

    R. Holtzapple

    2000-03-01

    Full Text Available Measurements of the beam's bunch length in the Cornell Electron-Positron Storage Ring (CESR have been made using a streak camera. The streak camera uses visible synchrotron radiation produced by the beam to measure its longitudinal distribution. A description of CESR, the experimental setup, the streak camera used, and systematic errors and analysis techniques of the streak camera are described in this paper. The dependence of the bunch distribution on the current and accelerating rf voltage for a single bunch CESR was measured and compared with a theoretical model of CESR. The CESR vacuum chamber impedance is determined from the measured bunch distributions and is presented in this paper.

  6. Beam dynamics performances and applications of a low-energy electron-beam magnetic bunch compressor

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, C. R.; Piot, P.; Carlsten, B. E.; Church, M.

    2013-08-01

    Many front-end applications of electron linear accelerators rely on the production of temporally compressed bunches. The shortening of electron bunches is often realized with magnetic bunch compressors located in high-energy sections of accelerators. Magnetic compression is subject to collective effects including space charge and self interaction via coherent synchrotron radiation. In this paper we explore the application of magnetic compression to low-energy (~40MeV), high-charge (nC) electron bunches with low normalized transverse emittances (<5@mm).

  7. Effects of the precursor electron bunch on quasi-phase matched direct laser acceleration

    Science.gov (United States)

    Lin, M.-W.; Hsieh, C.-Y.; Liu, Y.-L.; Chen, S.-H.; Jovanovic, I.

    2016-12-01

    Direct laser acceleration (DLA) of electrons can be achieved by utilizing the axial field of a well-guided, radially polarized laser pulse in a density-modulated plasma waveguide. When a laser pulse of a few terawatt (TW) peak power is applied, however, the laser ponderomotive force perturbs plasma electrons to concentrate in the center, such that the generated electrostatic fields can significantly defocus the externally injected electron witness bunch and considerably deteriorate the acceleration efficiency. To improve the performance of DLA, a leading electron bunch, which acts as a precursor, can be introduced in DLA to effectively confine the witness bunch. Three-dimensional particle-in-cell simulations have been conducted to demonstrate that the transverse properties of the witness bunch can be significantly improved when a precursor bunch is used. Selected bunch transverse sizes, bunch charges, and axial separation from the witness bunch have been assigned to the precursor in a series of DLA simulations. Since a favorable ion-focusing force is provided by the precursor, the transverse properties of witness bunch can be maintained when a relatively high-power (˜2 TW) laser pulse is used in DLA, and an improved overall acceleration efficiency can be achieved.

  8. Future developments in electron linac diagnostics

    CERN Document Server

    Ross, M C

    2004-01-01

    The next generation of electron linacs will fill two different roles: ultra-low emittance, very high power accelerators for linear colliders and ultra-short bunch, high stability accelerators for SASE X-ray production. In either case, precision control based on non-invasive, reliable, beam instrumentation will be required. For the linear collider, low emittance transport is an important concern for both warm and superconducting linacs. Instrumentation will be used to control and diagnostics will be used to validate emittance preserving strategies, such as beam based alignment and dispersion - free steering. Tests at the KEK ATF and the SLAC FFTB have demonstrated the required performance for beam position and beam size monitors. Linacs intended for FEL's will require precision bunch length diagnostics because of expected non-linear micro-bunching processes. A wide variety of devices are now in development at FEL prototypes, including TTF2 at DESY and SPPS at SLAC. We present a review of the new diagnostic ...

  9. Longitudinal bunch compression study with induction voltage modulator

    Directory of Open Access Journals (Sweden)

    Nakayama Akira

    2013-11-01

    Full Text Available For the beam driver of inertial confinement fusion, the technology to compress a charged particle beam in longitudinal direction is crucially important. However, the quality of the beam is expected to be deteriorated when the beam is rapidly compressed in longitudinal direction. In order to investigate the beam dynamics during bunch compression, we made a compact beam compression system and carried out beam compression experiments. In this paper, we show the background of our study and recent progress of the beam compression experiments.

  10. Optimized Bunch Compression System for the European XFEL

    CERN Document Server

    Limberg, Torsten; Brinkmann, Reinhard; Decking, Winfried; Dohlus, Martin; Flöettmann, Klaus; Kim, Yujong; Schneidmiller, Evgeny

    2005-01-01

    The European XFEL bunch compressor system has been optimized for greater flexibility in parameter space. Operation beyond the XFEL design parameters is discussed in two directions: achieving the uppermost number of photons in a single pulse on one hand and reaching the necessary peak current for lasing with a pulse as short as possible on the other. Results of start-to-end calculations including 3D-CSR effects, space charge forces and the impact on wake fields demonstrate the potential of the XFEL for further improvement or, respectively, its safety margin for operation at design values.

  11. The single-mode CSR instability for a bunched beam

    Energy Technology Data Exchange (ETDEWEB)

    Heifets, Samuel A

    2003-03-19

    The coherent synchrotron radiation (CSR) instability at the shielding threshold may be driven by a single synchronous mode excited by the beam in the beam pipe. The instability in this case has been analyzed [1] in the coasting beam approximation neglecting synchrotron motion. The later becomes important at large time intervals in storage rings where it substantially affects the beam dynamics. The single-mode CSR instability of a bunched beam with the synchrotron motion taken into account is described in this paper both in linear and nonlinear regimes. Analysis is relevant to other instabilities where the interaction is dominated by a single mode.

  12. Theory and Simulation of CSR Microbunching in Bunch Compressors

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Zhirong

    2002-11-26

    CSR microbunching instability in bunch compressors is studied both analytically and numerically. The iterative solutions of the integral equation for the instability provide approximate expressions of CSR microbunching due to initial density and energy modulation, and can be applied to a series of bending systems consisting of multiple compressor chicanes and transport lines. Two similar but independent simulation methods are developed and are compared to each other as well as with theory. We determine the total gain in density modulation for all bend systems of the Linac Coherent Light Source and discuss initial conditions that start the unstable process.

  13. STRESSORS, SYMPTOM PROFILE, AND PREDICTORS OF ADJUSTMENT DISORDER IN CANCER PATIENTS. RESULTS FROM AN EPIDEMIOLOGICAL STUDY WITH THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW, ADAPTATION FOR ONCOLOGY (CIDI-O).

    Science.gov (United States)

    Hund, Bianca; Reuter, Katrin; Härter, Martin; Brähler, Elmar; Faller, Hermann; Keller, Monika; Schulz, Holger; Wegscheider, Karl; Weis, Joachim; Wittchen, Hans-Ulrich; Koch, Uwe; Friedrich, Michael; Mehnert, Anja

    2016-02-01

    We aimed to investigate type and frequency of stressors, predominant symptom profiles, and predictors of adjustment disorders (AD) in cancer patients across major tumor entities. In this epidemiological study, we examined 2,141 cancer patients out of 4,020 screened with the Composite International Diagnostic Interview, adaptation for oncology (CIDI-O). AD were operationalized as subthreshold disorders according to DSM-IV criteria. In our sample, 265 out of 2,141 patients (12.4%) met all criteria for AD (unweighted 4-week prevalence). The disclosure of the cancer diagnosis, relapse or metastases, and cancer treatments were most frequently described as stressors associated with depressive or anxious symptoms. With regard to AD symptom profiles, patients showed high prevalence rates of affective symptoms according to the DSM-IV criteria of Major Depression: The highest prevalence rates were found for cognitive disturbances (concentration and memory problems) (88%), sleeping disturbances (86%), and depressive mood (83%). We found sex, education, and metastasis as significant predictors for AD. Higher education was the most influential predictor. Men were half as likely to report symptoms fulfilling the AD criteria as women. Patients with metastasized tumors had a more than 80% higher risk of AD than those without metastasis. However, the explained variance of our model is very small (Nagelkerke's R² = 0.08). Patients with AD can be identified using a standardized instrument and deserve clinical attention, as they often show severe clinical symptoms and impairments. Improving the clinical conceptualization of AD by the adding-on of potential stress-response-symptoms is necessary to identify severe psychological strain. © 2015 Wiley Periodicals, Inc.

  14. Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera.

    Science.gov (United States)

    Homann, Arne; Röckendorf, Niels; Kromminga, Arno; Frey, Andreas; Platts-Mills, Thomas A; Jappe, Uta

    2017-01-01

    Biological drugs like therapeutic antibodies are widely used for the treatment of various diseases like inflammatory disorders and cancer. A drawback of these novel treatments is the substantial proportion of patients experiencing adverse reactions such as loss-of-drug effect or hypersensitivity reactions. These reactions are associated with pre-existing and/or developing anti-drug antibodies. Especially IgE development is a risk factor for life-threatening systemic anaphylaxis. In order to characterize the individual drug-specific serum IgE, an IgE cross-reactivity immune profiling (ICRIP) assay was developed. Individual IgG epitopes of anti-drug antibodies against adalimumab were identified by epitope mapping via peptide microarray. ICRIP analyses of sera from patients treated with the therapeutic antibodies adalimumab (ADL) and infliximab (IFX) reveal individual, distinct IgE binding patterns. IgG epitopes were identified mostly located in the variable region of ADL. Using ICRIP and peptide microarrays for pharmacovigilance of the TNF-α blockers IFX and ADL, risk factors and biomarkers before and during therapy shall be identified. These diagnostic systems provide the basis for a safe and efficacious therapy decision for each patient in cases of adverse drug reactions mediated by different types of anti-drug antibodies.

  15. Diagnostic and prognostic role of MRI in spinal trauma, its comparison and correlation with clinical profile and neurological outcome, according to ASIA impairment scale

    Directory of Open Access Journals (Sweden)

    Umesh C Parashari

    2011-01-01

    Full Text Available Aims and objectives: To evaluate the role of magnetic resonance imaging (MRI as a non-invasive diagnostic tool in patients with acute and chronic spinal trauma and to compare and correlate the MRI findings with those of patients′ clinical profile and neurological outcome according to ASIA impairment scale to assess prognostic and clinical value of MRI. Materials and Methods: Sixty two patients of spinal trauma formed the study group in a prospective fashion. The patients undergoing MR imaging and magnetic resonance images were analyzed and correlated with findings on neurological examination according to American Spinal Injury Association (ASIA impairment scale (AIS at the time of MRI examination and subsequently at sub-acute interval to assess neurological outcome. Statistical Analysis : Sample profile was described in terms of 95% confidence limit and proportion. To describe strength of association between extent of spinal cord injury and outcome, odd′s ratio, bivariate and multi variant analysis, was used. Pearson′s chi square (χ 2 statistics was applied to test the association between two categorical variables. Data were analyzed using statistical software package, STATA 9.2 and the difference was considered to be significant if ′P′ value was <0.05. Observation and Results: The cord edema without hemorrhage was the most common MR finding (41.5%. The others were sizable focus of hemorrhage within the cord (33%, epidural hematoma (5.0%, and normal cord (26%. Majority of MR findings correlated well with clinical profile of the patient according to ASIA impairment scale. This study demonstrated that patients with presence of sizable focus of haemorrhage had larger cord edema and more severe grade of initial ASIA impairment scale( AIS with poor recovery at follow up (P=0.032.Improvement in upper extremity was more than lower extremity. Severe cord compression was also associated with poor neurological outcome; however it was not

  16. Violence Patterns in Peckinpah's The Wild Bunch (1969: Critical Reading

    Directory of Open Access Journals (Sweden)

    Baker Bani-Khair

    2017-03-01

    Full Text Available This paper focuses on the issue of violence in Sam Peckinpah's The Wild Bunch (1969 through explaining some of the cultural and historical implications of violence in the 1960s such as Vietnam War, the Mexican war and also the explosion of the feminist movement and some other important social and political upheavals that shaped the cultural context of the 1960s in America. It also sheds light on Sam Peckinpah’s approach of violence screen and stylizing violence and the representations of violence as a tormenting and brutalizing reality that matches the spirit of the age in addition to the social, political, and colonial conflicts of the 1960s. Violence and the implications of violence in The Wild Bunch whether social , cultural, psychological, or humanistic have been discussed in brief in order to show the critical approach of the film as being a rich and didactic film to watch, especially in terms of its rich cultural and historical contexts.

  17. DSP and FPGA Based Bunch Current Signal Processing

    CERN Document Server

    Naylor, G A

    2001-01-01

    The current in electron storage rings used as synchrotron light sources must be measured to a very high precision in order to determine the stored beam lifetime. This is especially so in high-energy machines in which the lifetime may be very high. Parametric current transformers (PCT) have traditionally been used to measure the DC or average current in the machine, which offer a very high resolution. Unfortunately these do not allow the different components of a complex filling pattern to be measured separately. A hybrid filling mode delivered at the ESRF consists of one third of the ring filled with bunches with a single highly populated bunch in the middle of the two-thirds gap. The lifetime of these two components may be very different. Similarly the two components are injected separately and can be monitored separately using a fast current transformer (FCT) or an integrating current transformer (ICT). The signals from these devices can be analysed using high speed analogue to digital converters operating ...

  18. Coherent synchrotron radiation and bunch stability in a compactstorage ring

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, Marco; Warnock, Robert; Ruth, Ronald; Ellison, James A.

    2004-04-09

    We examine the effect of the collective force due to coherent synchrotron radiation (CSR) in an electron storage ring with small bending radius. In a computation based on time-domain integration of the nonlinear Vlasov equation, we find the threshold current for a longitudinal microwave instability induced by CSR alone. The model accounts for suppression of radiation at long wave lengths due to shielding by the vacuum chamber. In a calculation just above threshold, small ripples in the charge distribution build up over a fraction of a synchrotron period, but then die out to yield a relatively smooth but altered distribution with eventual oscillations in bunch length. The instability evolves from small noise on an initial smooth bunch of r.m.s.length much greater than the shielding cutoff. The paper includes a derivation and extensive analysis of the complete impedance function Z for synchrotron radiation with parallel plate shielding. We find corrections to the lowest approximation to the coherent force which involve ''off-diagonal'' values of Z, that is, fields with phase velocity not equal to the particle velocity.

  19. Simulations of the effects of a superconducting damping wiggler on a short bunched electron beam at ANKA

    Energy Technology Data Exchange (ETDEWEB)

    Gethmann, Julian; Bernhard, Axel; Blomley, Edmund; Hillenbrand, Steffen; Mueller, Anke-Susanne; Smale, Nigel [Karlsruher Institut fuer Technologie (KIT) (Germany); Zolotarev, Konstantin [Budker Institute of Nuclear Physics (Russian Federation)

    2016-07-01

    (As a part of the CLIC collaboration) A CLIC damping wiggler prototype has been installed at the ANKA synchrotron light source in order to validate the technical design of the 3 T superconducting conduction cooled wiggler and its cryostat and to cary out studies on beam dynamical aspects including collective effects. The latter one will be the main focus in this talk. Collective effects that will occur in damping rings are an issue in ANKA's short bunch operation as well. To simulate these effects the accelerator's model including its insertion device has to be very accurate. Such a model of the ANKA storage ring in short bunch operation mode has been developed in elegant. Simulations with the damping wiggler switched on and off have been performed in order to investigate effects of the wiggler on different machine parameters. These new results will be discussed with regard to the question if on the one hand the wiggler could be used for diagnostic purposes and if on the other hand the wiggler's impact on the beam dynamics is changed by the collective effects.

  20. Conceptual design of a laser wakefield acceleration experiment with external bunch injection

    NARCIS (Netherlands)

    Khachatryan, A.G.; Luttikhof, M.J.H.; Irman, A.; van Goor, F.A.; Verschuur, Jeroen W.J.; Bastiaens, Hubertus M.J.; Boller, Klaus J.

    2006-01-01

    We present a conceptual design of a laser wakefield acceleration experiment where a sub-picosecond electron bunch from a photo-cathode RF linac is injected into a plasma channel just before a laser pulse. The pulse overtakes the bunch which is then trapped, compressed and accelerated in the laser

  1. Generation of ultra-short relativistic-electron-bunch by a laser wakefield

    NARCIS (Netherlands)

    Khachatryan, A.G.; Boller, Klaus J.; van Goor, F.A.

    2003-01-01

    The possibility of the generation of an ultra-short (about one micron long) relativistic (up to a few GeVs) electron-bunch in a moderately nonlinear laser wakefield excited in an underdense plasma by an intense laser pulse is investigated. The ultra-short bunch is formed by trapping, effective

  2. Effect of varying rates of Palm Bunch Ash on maize yield in a ...

    African Journals Online (AJOL)

    Field experiment was conducted to determine the effect of varying rates of palm bunch ash on the grain yield of maize (Zea mays). The experiment was laid out in a randomized complete block design (RCBD) with four treatments replicated three times. The treatments were 0, 100, 200 and 300kg Palm bunch ash/ha.

  3. Beam simulations with initial bunch noise in superconducting RF proton linacs

    CERN Document Server

    Tückmantel, J

    2010-01-01

    Circular machines are plagued by coupled bunch instabilities (CBI), driven by impedance peaks, where then all cavity higher order modes (HOMs) are possible drivers. Limiting the CBI growth rate is the fundamental reason that all superconducting rf cavities in circular machines are equipped with HOM dampers. The question arises if for similar reasons HOM damping would not be imperative also in high current superconducting rf proton linacs. Therefore we have simulated the longitudinal bunched beam dynamics in such machines, also including charge and position noise on the injected bunches. Simulations were executed for a generic linac with properties close to the planned SPL at CERN, SNS, or Project X at FNAL. It was found that with strong bunch noise and monopole HOMs with high Qext large beam scatter, possibly exceeding the admittance of a receiving machine, cannot be excluded. A transverse simulation shows similar requirements. Therefore including initial bunch noise in any beam dynamic study on superconducti...

  4. Non-destructive measurement and monitoring of separation of charged particle micro-bunches

    Science.gov (United States)

    Zhang, H.; Konoplev, I. V.; Lancaster, A. J.; Harrison, H.; Doucas, G.; Aryshev, A.; Shevelev, M.; Terunuma, N.; Urakawa, J.

    2017-07-01

    Micro-bunched particle beams are used for a wide range of research including wakefield-based particle acceleration and tunable sources of radiation. In all applications, accurate and non-destructive monitoring of the bunch-to-bunch separation is required. With the development of femtosecond lasers, the generation of micro-bunched beams directly from a photocathode becomes routine; however, non-destructive monitoring of the separation is still a challenge. We present the results of proof-of-principle experiments conducted at the Laser Undulator Compact X-ray accelerator measuring the distance between micro-bunches via the amplitude modulation analysis of a monochromatic radiation signal. Good agreement with theoretical predictions is shown; limitations and further improvements are discussed.

  5. An Electron Bunch Compression Scheme for a Superconducting Radio Frequency Linear Accelerator Driven Light Source

    Energy Technology Data Exchange (ETDEWEB)

    C. Tennant, S.V. Benson, D. Douglas, P. Evtushenko, R.A. Legg

    2011-09-01

    We describe an electron bunch compression scheme suitable for use in a light source driven by a superconducting radio frequency (SRF) linac. The key feature is the use of a recirculating linac to perform the initial bunch compression. Phasing of the second pass beam through the linac is chosen to de-chirp the electron bunch prior to acceleration to the final energy in an SRF linac ('afterburner'). The final bunch compression is then done at maximum energy. This scheme has the potential to circumvent some of the most technically challenging aspects of current longitudinal matches; namely transporting a fully compressed, high peak current electron bunch through an extended SRF environment, the need for a RF harmonic linearizer and the need for a laser heater. Additional benefits include a substantial savings in capital and operational costs by efficiently using the available SRF gradient.

  6. Self-amplified coherent spontaneous emission in a free electron laser with “quiet” bunches

    Directory of Open Access Journals (Sweden)

    V. A. Goryashko

    2013-03-01

    Full Text Available For a planar free electron laser (FEL configuration we study self-amplified coherent spontaneous emission driven by a gradient of the bunch current in the presence of different levels of noise in bunches. The longitudinal granularity of the electron bunch density originating from shot noise is maintained throughout the analysis. For the FEL model with the SwissFEL injector bunch parameters, we calculate the probability density distribution of the maximum power of the radiation pulses for different levels of shot noise. It turns out that the temporal coherence quickly increases as the noise level reduces. We also show that the FEL based on coherent spontaneous emission produces almost Fourier transform limited pulses. The analysis indicates that the time-bandwidth product is mainly determined by the bunch length and the interaction distance in an undulator. Calculations of the FEL characteristics for different rise times of the front of the current pulse are performed, and it is found that a reduced level of the power fluctuations is preserved for the bunch current pulse with a front duration up to several FEL wavelengths. We also propose a novel scheme that permits the formation of electron bunches with a reduced level of noise and a high gradient of the current at the bunch tail to enhance coherent spontaneous emission. The presented scheme uses effects of noise reduction and controlled microbunching instability and consists of a laser heater, a bunch compressor, and a shot noise suppression section. We show that shot noise reduction by 2 orders of magnitude in electron bunches produced by the SwissFEL injector can be achieved in a compact noise suppression section. The noise factor and microbunching gain of the overall proposed scheme with and without laser heater are estimated.

  7. Investigations on the electron bunch distribution in the longitudinal phase space at a laser driven RF electron source for the European X-FEL

    Energy Technology Data Exchange (ETDEWEB)

    Roensch, Juliane

    2010-01-15

    The Photoinjector Test facility at DESY, Zeuthen site, (PITZ) is aiming for the optimization of electron guns for SAS-FELs. For this it is necessary to investigate the characteristics of the six dimensional phase space of the bunch produced by a photoinjector. This thesis is focused on the analysis of the longitudinal properties of the electron bunch distribution, this means the temporal current distribution and the momentum distribution as well as the correlation of both properties. The complete distribution of the electron bunch in longitudinal phase space of a photoinjector was measured directly for the first time at a beam momentum of about 5 MeV/c, using an existing apparatus. This system had been designed for an accelerating gradient of 40 MV/m. Its subcomponents were analysed to understand sources of uncertainties of the measurement system. The usage of higher accelerating gradients in the gun (60 MV/m, resulting in a beam momentum of about 6.8 MeV/c) demands major modifications of the existing measurement system for the longitudinal phase space distribution. An upgrade of the facility by an additional accelerating cavity required the design of further longitudinal diagnostics systems for the analysis at higher momenta (up to 40 MeV/c). Measurements of the longitudinal beam properties to determine the influence of different operation parameters, like RF launch phase, charge, accelerating field gradient and laser distribution were performed and compared to simulations. (orig.)

  8. Direct observation of beam bunching in BWO experiments

    CERN Document Server

    Morimoto, I; Maebara, S; Kishiro, J; Takayama, K; Horioka, K; Ishizuka, H; Kawasaki, S; Shiho, M

    2001-01-01

    Backward Wave Oscillation (BWO) experiments using a Large current Accelerator-1 (Lax-1) Induction Linac as a seed power source for an mm-wave FEL are under way. The Lax-1 is typically operated with a 1 MeV electron beam, a few kA of beam current, and a pulse length of 100 ns. In the BWO experiments, annular and solid beams are injected into a corrugated wave guide with guiding axial magnetic field of 1 T. In the BWO with annular beam an output power of 210 MW at 9.8 GHz was obtained. With a solid beam the output power was 130 MW, and an electron beam bunching with the frequency of 9.6-10.2 GHz was observed by a streak camera.

  9. Gridded thermionic gun and integral superconducting ballistic bunch compression cavity

    Energy Technology Data Exchange (ETDEWEB)

    Schultheiss, Thomas [Advanced Energy Systems, Inc., Medford, NY (United States)

    2015-11-16

    Electron-Ion colliders such as the Medium energy Electron Ion Collider (MEIC) being developed by JLAB require high current electrons with low energy spread for electron cooling of the collider ring. Accelerator techniques for improving bunch charge, average current, emittance, and energy spread are required for Energy Recovery Linacs (ERLs) and Circulator Rings (CR) for next generation colliders for nuclear physics experiments. Example candidates include thermionic-cathode electron guns with RF accelerating structures. Thermionic cathodes are known to produce high currents and have excellent lifetime. The success of the IR and THz Free-Electron Laser (FEL) designed and installed by Advanced Energy Systems at the Fritz Haber Institute (FHI) of the Max Planck Society in Berlin [1,2] demonstrates that gridded thermionic cathodes and rf systems be considered for next generation collider technology. In Phase 1 Advanced Energy Systems (AES) developed and analyzed a design concept using a superconducting cavity pair and gridded thermionic cathode. Analysis included Beam Dynamics and thermal analysis to show that a design of this type is feasible. The latest design goals for the MEIC electron cooler were for electron bunches of 420 pC at a frequency of 952.6 MHz with a magnetic field on the cathode of 2kG. This field magnetizes the beam imparting angular momentum that provides for helical motion of the electrons in the cooling solenoid. The helical motion increases the interaction time and improves the cooling efficiency. A coil positioned around the cathode providing 2kG field was developed. Beam dynamics simulations were run to develop the particle dynamics near the cathode and grid. Lloyd Young added capability to Tstep to include space charge effects between two plates and include image charge effects from the grid. He also added new pepper-pot geometry capability to account for honeycomb grids. These additions were used to develop the beam dynamics for this gun. The

  10. Effects of the Passive Harmonic Cavity on the Beam Bunch

    CERN Document Server

    Chang Lung Hai; Wang, Chaoen; Yeh, Meng-Shu

    2005-01-01

    In this paper, we present a computer tracking code, which can investigate the bunch length, energy spread and the critical current of Robinson instability under the influence of the passive harmonic cavity. The effects of the radiation damping, quantum excitation and the beam loading of the harmonic cavity are included in the computation. The calculated result shows that the beam has a constant energy spread and blows up as the beam current increases from below to over the threshold current of the Robinson instability. It also indicates that the shunt impedance of the harmonic cavity is critical for whether the harmonic cavity can reach the designed goal, a stable and lengthening beam at the design beam current.

  11. Torrefaction of empty fruit bunches under biomass combustion gas atmosphere.

    Science.gov (United States)

    Uemura, Yoshimitsu; Sellappah, Varsheta; Trinh, Thanh Hoai; Hassan, Suhaimi; Tanoue, Ken-Ichiro

    2017-11-01

    Torrefaction of oil palm empty fruit bunches (EFB) under combustion gas atmosphere was conducted in a batch reactor at 473, 523 and 573K in order to investigate the effect of real combustion gas on torrefaction behavior. The solid mass yield of torrefaction in combustion gas was smaller than that of torrefaction in nitrogen. This may be attributed to the decomposition enhancement effect by oxygen and carbon dioxide in combustion gas. Under combustion gas atmosphere, the solid yield for torrefaction of EFB became smaller as the temperature increased. The representative products of combustion gas torrefaction were carbon dioxide and carbon monoxide (gas phase) and water, phenol and acetic acid (liquid phase). By comparing torrefaction in combustion gas with torrefaction in nitrogen gas, it was found that combustion gas can be utilized as torrefaction gas to save energy and inert gas. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Characterization of cellulose extracted from oil palm empty fruit bunch

    Science.gov (United States)

    Sisak, Muhammad Asri Abdul; Daik, Rusli; Ramli, Suria

    2015-09-01

    Recently, cellulose has been studied by many researchers due to its promising properties such as biodegradability, biocompatibility, hydrophilicity and robustness. Due to that it is applied in many fields such as paper, film, drug delivery, membranes, etc. Cellulose can be extracted from various plants while oil palm empty fruit bunch (OPEFB) is the one of its sources. In this study, cellulose was extracted by chemical treatments which involved the use of formic acid and hydrogen peroxide to remove hemicellulose and lignin components. Maximum yield was 43.22%. Based on the FT-IR spectra, the peak of wax (1735 cm-1), hemicellulose (1375 cm-1) and lignin (1248 cm-1 and 1037 cm-1) were not observed in extracted cellulose. TGA analysis showed that the extracted cellulose starts to thermally degrade at 340 °C. The SEM analysis suggested that the cellulose extracted from OPEFB was not much different from commercial cellulose.

  13. Analytical Formulas for Short Bunch Wakes in a Flat Dechirper

    Energy Technology Data Exchange (ETDEWEB)

    Bane, Karl [SLAC National Accelerator Lab., Menlo Park, CA (United States); Stupakov, Gennady [SLAC National Accelerator Lab., Menlo Park, CA (United States); Zagorodnov, Igor [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2016-03-29

    We develop analytical models of the longitudinal and transverse wakes, on and off axis for realistic structures, and then compare them with numerical calculations, and generally find good agreement. These analytical "first order" formulas approximate the droop at the origin of the longitudinal wake and of the slope of the transverse wakes; they represent an improvement in accuracy over earlier, "zeroth order" formulas. In example calculations for the RadiaBeam/LCLS dechirper using typical parameters, we find a 16% droop in the energy chirp at the bunch tail compared to simpler calculations. With the beam moved to 200 m from one jaw in one dechiper section, one can achieve a 3 MV transverse kick differential over a 30 m length.

  14. Hydrothermal pretreatment of palm oil empty fruit bunch

    Science.gov (United States)

    Simanungkalit, Sabar Pangihutan; Mansur, Dieni; Nurhakim, Boby; Agustin, Astrid; Rinaldi, Nino; Muryanto, Fitriady, Muhammad Ariffudin

    2017-01-01

    Hydrothermal pretreatment methods in 2nd generation bioethanol production more profitable to be developed, since the conventional pretreatment, by using acids or alkalis, is associated with the serious economic and environmental constraints. The current studies investigate hydrothermal pretreatment of palm oil empty fruit bunch (EFB) in a batch tube reactor system with temperature and time range from 160 to 240 C and 15 to 30 min, respectively. The EFB were grinded and separated into 3 different particles sizes i.e. 10 mesh, 18 mesh and 40 mesh, prior to hydrothermal pretreatment. Solid yield and pH of the treated EFB slurries changed over treatment severities. The chemical composition of EFB was greatly affected by the hydrothermal pretreatment especially hemicellulose which decreased at higher severity factor as determined by HPLC. Both partial removal of hemicellulose and migration of lignin during hydrothermal pretreatment caused negatively affect for enzymatic hydrolysis. This studies provided important factors for maximizing hydrothermal pretreatment of EFB.

  15. Bunching and cooling of radioactive ions with REXTRAP

    CERN Document Server

    Schmidt, P; Bollen, G; Forstner, O; Huber, G; Oinonen, M; Zimmer, J

    2002-01-01

    The post-accelerator REX-ISOLDE at ISOLDE/CERN will deliver radioactive ion beams with energies up to 2.2 MeV/u. For this purpose, a Penning trap and an electron-beam ion source are combined with a linear accelerator. REXTRAP—a large gas-filled Penning trap—has started its commissioning phase. First tests have shown that REXTRAP is able to accumulate, cool and bunch stable ISOLDE ion beams covering a large mass range. Fulfilling the REX-ISOLDE demands, it can handle beam intensities from a few hundred up to 1×10 6 ions per pulse at repetition rates up to 50 Hz.

  16. Estimates of post-acceleration longitudinal bunch compression

    Energy Technology Data Exchange (ETDEWEB)

    Judd, D.L.

    1977-11-25

    A simple analytic method is developed, based on physical approximations, for treating transient implosive longitudinal compression of bunches of heavy ions in an accelerator system for ignition of inertial-confinement fusion pellet targets. Parametric dependences of attainable compressions and of beam path lengths and times during compression are indicated for ramped pulsed-gap lines, rf systems in storage and accumulator rings, and composite systems, including sections of free drift. It appears that for high-confidence pellets in a plant producing 1000 MW of electric power the needed pulse lengths cannot be obtained with rings alone unless an unreasonably large number of them are used, independent of choice of rf harmonic number. In contrast, pulsed-gap lines alone can meet this need. The effects of an initial inward compressive drift and of longitudinal emittance are included.

  17. Single-Bunch Stability With Direct Space Charge

    CERN Multimedia

    Oeftiger, Adrian

    2017-01-01

    Previous studies have shown the suppressing effect of direct space charge on impedance-driven head-tail instabilities. The present work investigates transverse stability for the HL-LHC scenario based on our macro-particle simulation tool PyHEADTAIL using realistic bunch distributions. The impact of selfconsistent modelling is briefly discussed for non-linear space charge forces. We study how space charge pushes the instability threshold for the transverse mode coupling instability (TMCI) occurring between mode 0 and -1. Next we consider finite chromaticity: in absence of space charge, the impedance model predicts head-tail instabilities. For a selected case below TMCI threshold at Q0 = 5, we demonstrate the stabilising effect of space charge. Finally, we compare simulation results to past LHC measurements.

  18. Evaluating oil palm fresh fruit bunch processing in Nigeria.

    Science.gov (United States)

    Anyaoha, Kelechi E; Sakrabani, Ruben; Patchigolla, Kumar; Mouazen, Abdul M

    2018-03-01

    Three routes of oil palm fresh fruit bunch (FFB) processing in Nigeria namely, industrial, small-scale and traditional were compared by means of determining fruit losses associated with each route. The fruits that are not recovered after each process were hand-picked and quantified in terms of crude palm oil (CPO), palm kernel (PK), mesocarp fibre (MF) and palm kernel shell (PKS). The energy value of empty fruit bunch (EFB), MF and PKS were used to determine the value of energy lost for each route. Additionally, the environmental implications of disposal of EFB were estimated, and socio-economics of the industrial and small-scale routes were related. The analysis showed that 29, 18, 75 and 27 kg of CPO, PK, MF and PKS were lost for every 1000 kg of FFB processed with the industrial route, whereas 5.6, 3.2, 1.4 and 5.1 g were lost with the small-scale route, respectively. Approximately 89 kWh and 31 kWh more energy were lost from MF and PKS with the industrial route than the other two routes, respectively. An equivalent of 6670 tonnes carbon dioxide equivalent of methane and nitrogen oxide was released due to the disposal of 29,000 tonnes of EFB from one palm oil mill. The monetary value of lost CPO per 1000 kg of FFB processed in the industrial route is more than the labour cost of processing 1000 kg of FFB in the small-scale route. The advantages of the industrial route are high throughput in terms of FFB processed per hour and high quality of CPO; however, high fruit loss is associated with it and therefore, the poorly threshed EFB is recommended to be fed into the small-scale route.

  19. VISCOSITY ANALYSIS OF EMPTY FRUIT BUNCH (EFB BIO-OIL

    Directory of Open Access Journals (Sweden)

    Z.S. Nazirah

    2013-12-01

    Full Text Available Empty fruit bunches (EFB are one of the solid wastes produced by the palm oil industry, which is increasing rapidly. The aim of this paper is to analyse the viscosity of empty fruit bunch (EFB bio-oil that can be extracted from all solid waste EFB as a sample, and a few processes were executed. The samples underwent two processes, which were pre-treatment and pyrolysis. The pre-treatment involved three processes, namely, cutting, shredding and sieving, which were necessary in order to prepare EFB into a particle size suitable for the reactor. After that, the samples were fed into the feedback reactor as feedstock for the pyrolysis process to produce bio-oil. Once the bio-oil was produced, its viscosity was tested using the Brookfield Viscometer in two conditions: before and after the chemical reaction. The bio-oil was treated by adding 10 ml and 20 ml of acetone respectively through the chemical reaction. The viscosity test was carried out at different temperatures, which were 25°C, 30°C, 35°C, 40°C, 45°C and 50°C respectively. The observed viscosity of the EFB bio-oil varied and was higher as the temperature decreased. In addition, the viscosity of the EFB bio-oil was higher when it reacted chemically with the acetone added. Therefore, the results showed that the chemical reaction with acetone has the potential to increase the viscosity of EFB bio-oil.

  20. Real-time diagnostics at ASDEX Upgrade-Architecture and operation

    Energy Technology Data Exchange (ETDEWEB)

    Behler, K. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany)], E-mail: karl.behler@ipp.mpg.de; Blank, H.; Eixenberger, H.; Lohs, A. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany); Lueddecke, K. [UCS GmbH, Seeshaupter Strasse 15, 82393 Iffeldorf (Germany); Merkel, R.; Raupp, G.; Schramm, G.; Treutterer, W.; Zilker, M. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany)

    2008-04-15

    Diagnostics at ASDEX Upgrade have available a very large number of highly developed measuring channels. The prospect of making this wealth of information usable for plasma optimisation led to the implementation of a number of diagnostics running data acquisition in real-time (RT). Ultimately, this development aims to achieve a network of intelligent diagnostics delivering analysed data for high-level plasma performance control such as profile shaping and NTM stabilisation. The new RT diagnostics consist of standard industrial 19 in. servers organised in clusters and running a standard UNIX multiprocessor RT-capable operating system (RT OS). Built-to-purpose computer interface cards deliver data (e.g. via serial links) from the data acquisition (DAQ) front-ends directly into the main memory of the DAQ servers. An RT data analysis task immediately following the running direct memory access (DMA) data transfers processes the data and delivers the results to follow-up systems in the control chain. Whereas the first systems were implemented in a simple just a bunch of computers (JBOC) configuration being operated as a number of single diagnostics, newer systems are integrated into diagnostic clusters using parallel computing techniques such as message passing interface (MPI). The paper describes the hardware (ADC front-ends, serial I/O, selection criteria and performance of the involved computer busses and systems) and software (DAQ, DA, RT OS, MPI) architecture of the assembled systems. Benchmark results for DAQ and MPI bandwidth and latencies as well as for the behaviour of the RT OS will be given.

  1. Bunch merging and splitting techniques in the injectors for high energy hadron colliders

    CERN Document Server

    Garoby, R

    1998-01-01

    One problem in the design of TeV hadron colliders arises from the choice of the radio frequency. To produce economically the short bunches needed during collision, a high frequency (400 MHz or more) is essential. On the other hand, in the injector chain at lower energies, lower frequencies are generally preferred to alleviate space charge and instability problems and, partially also, for historical reasons. The classical solution is to transform the bunch structure by passing via a debunched beam state, during which the whole machine circumference becomes filled with particles and the beam is subjected to induced parasitic fields and is often prone to microwave instabilities. Bunch merging and bunch splitting have therefore been developed as alternative methods that allow the number of bunches to be changed without passing via that state. Bunch merging has been used in the CERN-PS since 1989 for the anti-proton production beam. The reverse process of bunch splitting was first proposed in the frame of the CERN...

  2. A hybrid approach for generating ultra-short bunches for advanced accelerator applications

    Energy Technology Data Exchange (ETDEWEB)

    Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-01

    Generation of electron beams with high phase-space density, short bunch length and high peak current is an essential requirement for future linear colliders and bright electron beam sources. Unfortunately, such bunches cannot be produced directly from the source since forces from the mutual repulsion of electrons would destroy the brilliance of the beam within a short distance. Here, we detail a beam dynamics study of an innovative two-stage compression scheme that can generate ultra-short bunches without degrading the beam quality. In the first stage, the beam is compressed with an advanced velocity bunching technique in which the longitudinal phase space is rotated so that electrons on the bunch tail become faster than electrons in the bunch head. In the second stage, the beam is further compressed with a conventional magnetic chicane. With the aid of numerical simulations we show that our two-staged scheme is capable to increase the current of a 50 pC bunch to a notable factor of 100 while the emittance growth can be suppressed to 1% with appropriate tailoring of the initial beam distribution.

  3. Analytical bunch compression studies for a linac-based electron accelerator

    Directory of Open Access Journals (Sweden)

    M. Schreck

    2015-10-01

    Full Text Available The current paper deals with analytical bunch compression studies for FLUTE whose results are compared to simulations. FLUTE is a linac-based electron accelerator with a design energy of approximately 40 MeV currently being constructed at the Karlsruhe Institute of Technology. One of the goals of FLUTE is to generate electron bunches with their length lying in the femtosecond regime. In the first phase this will be accomplished using a magnetic bunch compressor. This compressor forms the subject of the studies presented. The paper is divided into two parts. The first part deals with pure geometric investigations of the bunch compressor where space charge effects and the backreaction of bunches with coherent synchrotron radiation are neglected. The second part is dedicated to the treatment of space charge effects. The upshot is that the analytical results in the two parts agree quite well with what is obtained from simulations. This paper shall form the basis for future analytical studies of the FLUTE bunch compressor and of bunch compression, in general.

  4. Generation and Use of Coherent Transition Radiation from Short Electron Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Settakorn, Chitrlada

    2001-08-28

    When accelerated, an electron bunch emits coherent radiation at wavelength longer than or comparable to the bunch length. The coherent radiation intensity scales with the square of the number of electron per bunch and its radiation spectrum is determined by the Fourier Transform of the electron bunch distribution squared. At the SUNSHINE (Stanford University Short Intense Electron Source) facility, electron bunches can be generated as short as {sigma}{sub z} = 36 {micro}m (120 femtosecond duration) and such bunches can emit coherent radiation in the far-infrared. Since a typical number for the electron population in a bunch is 10{sup 8}-10{sup 9}, the coherent radiation intensity is much higher than that of incoherent radiation as well as that of a conventional far-infrared radiation source. This concentrates on coherent transition and diffraction radiation from short electron bunches as a potential high intensity far-infrared radiation source and for sub-picosecond electron bunch length measurements. Coherent transition radiation generated from a 25 MeV beam at a vacuum-metal interface is characterized. Such a high intensity radiation source allows far-infrared spectroscopy to be conducted conveniently with a Michelson interferometer and a room temperature detector. Measurements of the refractive index of silicon are described to demonstrate the possibilities of far-infrared spectroscopy using coherent transition radiation Coherent diffraction radiation, which is closely related to coherent transition radiation, can be considered as another potential FIR radiation source. Since the perturbation by the radiation generation to the electron beam is relatively small, it has the advantage of being a nondestructive radiation source.

  5. Transverse modes and instabilities of a bunched beam with space charge and resistive wall impedance

    Energy Technology Data Exchange (ETDEWEB)

    Balbekov, V.; /Fermilab

    2011-11-01

    Transverse instability of a bunch in a ring accelerator is considered with space charge and wakefield taken into account. It is assumed that space charge tune shift significantly exceeds the synchrotron tune. Bunch spectrum, instability growth rate, and effects of chromaticity are studied with different bunch and wake forms. Fast instability caused by coupling of transverse modes is studied in detail. It is shown that, for monotonic wakes, the transverse mode coupling instability is possible only with a certain sign of the wake. Its threshold and growth rate are calculated precisely over a wide range of parameters.

  6. Temporal Characterization of Electron Beam Bunches with a Fast Streak Camera at the JLab FEL Facility

    CERN Document Server

    Zhang, S; Douglas, D; Hardy, D; Hernandez-Garcia, C; Jordan, K; Neil, G; Shinn, M D

    2005-01-01

    The design and construction of an optical transport that brings synchrotron radiation from electron bunches to a fast streak camera in a remote area has become a useful tool for online observation of bunch length and stability. This paper will report on the temporal measurements we have done, comparison with simulations, and the on-going work for another imaging optical transport system that will make possible the direct measurement of the longitudinal phase space by measuring the bunch length as a function of energy.

  7. In vitro and in silico characterization of metagenomic soil-derived cellulases capable of hydrolyzing oil palm empty fruit bunch.

    Science.gov (United States)

    Medina, Laura Marcela Palma; Ardila, Diana Catalina; Zambrano, María Mercedes; Restrepo, Silvia; Barrios, Andrés Fernando González

    2017-09-01

    Diversification of raw material for biofuel production is of interest to both academia and industry. One attractive substrate is a renewable lignocellulosic material such as oil palm (Elaeis guineensis Jacq.) empty fruit bunch (OPEFB), which is a byproduct of the palm oil industry. This study aimed to characterize cellulases active against this substrate. Cellulases with activity against OPEFB were identified from a metagenomic library obtained from DNA extracted from a high-Andean forest ecosystem. Our findings show that the highest cellulolytic activities were obtained at pH and temperature ranges of 4-10 and 30 °C-60 °C, respectively. Due to the heterogeneous character of the system, degradation profiles were fitted to a fractal-like kinetic model, evidencing transport mass transfer limitations. The sequence analysis of the metagenomic library inserts revealed three glycosyl hydrolase families. Finally, molecular docking simulations of the cellulases were carried out corroborating possible exoglucanase and β-glucosidase activity.

  8. Multi-proton bunch driven hollow plasma wakefield acceleration in the nonlinear regime

    Science.gov (United States)

    Li, Yangmei; Xia, Guoxing; Lotov, Konstantin V.; Sosedkin, Alexander P.; Hanahoe, Kieran; Mete-Apsimon, Oznur

    2017-10-01

    Proton-driven plasma wakefield acceleration has been demonstrated in simulations to be capable of accelerating particles to the energy frontier in a single stage, but its potential is hindered by the fact that currently available proton bunches are orders of magnitude longer than the plasma wavelength. Fortunately, proton micro-bunching allows driving plasma waves resonantly. In this paper, we propose using a hollow plasma channel for multiple proton bunch driven plasma wakefield acceleration and demonstrate that it enables the operation in the nonlinear regime and resonant excitation of strong plasma waves. This new regime also involves beneficial features of hollow channels for the accelerated beam (such as emittance preservation and a uniform accelerating field) and long buckets of stable deceleration for the drive beam. The regime is attained at a proper ratio between plasma skin depth, driver radius, hollow channel radius, and micro-bunch period.

  9. Short energetic electron bunches from laser wakefield accelerator with orthogonally polarized perpendicularly crossed laser pulses

    Science.gov (United States)

    Horný, Vojtěch; Petržílka, Václav; Klimo, Ondřej; Krůs, Miroslav

    2017-05-01

    Electron acceleration with optical injection by a perpendicularly propagating and orthogonally polarized low intensity laser pulse into a nonlinear plasma wave driven by a short intense laser pulse was explored by particle- in-cell simulations. The scheme presented here provides an energetic electron bunch in the first ion cavity with a low energy spread. The electron bunch short and compact, with the mean energy about 400 MeV and a low energy spread about 10 MeV in time of 6 ps of acceleration. The injected charge is several tens of pC for the low intensity of the injection pulse. Initial positions of electrons forming the energetic bunch are shown and then these electrons are followed during the simulation in order to understand the injection process and determine electron bunch properties.

  10. High-intensity coherent FIR radiation from sub-picosecond electron bunches

    Energy Technology Data Exchange (ETDEWEB)

    Kung, P.H.; Lihn, Hung-chi; Wiedemann, H.; Bocek, D.

    1994-01-01

    A facility to generate high-intensity, ultra-short pulses of broad-band far-infrared radiation has been assembled and tested at Stanford. The device uses sub-picosecond relativistic electron bunches to generate coherent radiation through transition or synchrotron radiation in the far-infrared (FIR) regime between millimeter waves and wavelengths of about 100 {mu}m and less. Experimental results show a peak radiation power of greater than 0.33 MW within a micro-bunch and an average FIR radiation power of 4 mW. The average bunch length of 2856 micro-bunches within a 1 {mu}sec macro-pulse is estimated to be about 480 sec. Simulations experimental setup and results will be discussed.

  11. Modeling of intense charged particle bunch dynamics in external magnetic fields

    Science.gov (United States)

    Barminova, H. Y.; Saratovskyh, M. S.

    2015-09-01

    Program module CAMFT is developed to simulate the intense charged particle bunch dynamics in external magnetic fields. The program is based on the accurate solution of the motion equation for each particle of the intense bunch. The program is written on C++ language and uses standart OpenMP (version 2.0) for parallelization, so one can simulate the behavior of the bunch with intensity about 109-1010 particles. Visual C++ and library Qt 4.8.3 of qtcreator are used for the result visualization. Dynamics of the bunch with arbitrary phase distributions in magnetic fields of arbitrary geometry may be studied by means of the program. The actual CAMFT version is checked while simulating the accelerating structure with racetrack geometry. Modified CAMFT version is checked for ITEP Heavy-Ion Prototype charge-state separator.

  12. Synthesis and Electrochemical Sensing Toward Heavy Metals of Bunch-like Bismuth Nanostructures

    Directory of Open Access Journals (Sweden)

    Zhang Zhi

    2009-01-01

    Full Text Available Abstract Large-scale bunch-like bismuth (Bi nanostructures were the first time to be synthesized via two-step electrochemical deposition. The growth mechanism of the nanostructures was discussed. Such a designed bunch-like Bi electrode has high sensitivity to detect the heavy metal ions due to its unique three-dimensional structures and strong ability of adsorbing the heavy metal ions. The bunch-like Bi electrode’s detection of heavy metals was statically performed using anodic stripping voltammetry (ASV. The detection in the Pb(II concentration range of 2.5–50 μg/l was also performed. Based on the experimental results, this bunch-like Bi electrode can be considered as an interesting alternative to common mercury electrodes and bismuth film electrodes for possible use in electrochemical studies and electroanalytical applications.

  13. Distinct physiological responses underlie defoliation tolerance in African lawn and bunch grasses

    NARCIS (Netherlands)

    Anderson, T.M.; Kumordzi, B.B.; Fokkema, W.; Valls Fox, H.; Olff, H.

    Premise of research. African grass communities are dominated by two distinct functional types: tall, caespitose bunch grasses and short, spreading lawn grasses. Functional type coexistence has been explained by differences in defoliation tolerance, because lawn grasses occur in intensively grazed

  14. CSR Effects in a Bunch Compressor influence of the Beam Frame Transverse Force

    CERN Document Server

    Bassi, G

    2005-01-01

    We study the influence of coherent synchrotron radiation (CSR) on particle bunches traveling on arbitrary planar orbits between parallel conducting plates (shielding) with a Vlasov approach. [1] The fields excited by the bunch are computed in the lab frame using a formula simpler than that based on retarded potentials. The Vlasov equation is solved in the beam frame interaction picture. In recent numerical investigations we solved the Vlasov equation for a bunch compressor using the Liouville-Maxwell approximation (LMA), where the bunch density is evolved under the fields produced by the unperturbed density (subject to external fields only), neglecting the beam frame transverse force. [2] Here we report on the influence of the beam frame transverse force on the equations of motion.

  15. LHC MD 1087: Controlled Longitudinal Emittance Blow-up with Short Bunches

    CERN Document Server

    Timko, Helga; Esteban Muller, Juan; Jaussi, Michael; Lasheen, Alexandre; Shaposhnikova, Elena; CERN. Geneva. ATS Department

    2017-01-01

    The aim of the MD was to study the controlled longitudinal emittance blow-up applied during the ramp with bunches that are slightly shorter than operational. Earlier MDs in 2015 have shown that with a short target bunch length, the blow-up is less controlled and a bifurcation of bunch lengths occurs. The presented measurements show that the bifurcation is independent of the presence of the bunch length feedback, pointing towards an intensity-dependent phenomenon, originating from a synchrotron frequency shift with intensity. Accurate measurements of synchrotron frequency shift with intensity are presented as well. The measurements took place between 22nd August 2016, 19:00 and 23rd August 2016, 04:00.

  16. Head-tail instability and Landau damping in bunches with space charge

    Directory of Open Access Journals (Sweden)

    V. Kornilov

    2010-11-01

    Full Text Available Head-tail modes in bunches with space charge are studied using particle tracking simulations. The eigenfrequencies and eigenfunctions of transverse coherent oscillations in a Gaussian bunch are determined and compared with theories. A model for an airbag distribution in a barrier potential gives good predictions for the head-tail spectrum and for eigenfunctions in bunches with space charge. Using numerical simulations, space-charge induced Landau damping in a bunch is demonstrated. The damping rates are quantified for different modes and space-charge tune shifts. Finally, the head-tail instability with space charge is studied for the resistive-wall impedance below the mode coupling threshold. Results demonstrate that space-charge induced damping can suppress the instability for moderately strong space charge; instability growth rates saturate at strong space charge, in agreement with theoretical predictions.

  17. Overall comparison of subpicosecond electron beam diagnostics by the polychromator, the interferometer and the femtosecond streak camera

    CERN Document Server

    Watanabe, T; Yoshimatsu, T; Sasaki, S; Sugiyama, Y; Ishi, K; Shibata, Y; Kondo, Y; Yoshii, K; Ueda, T; Uesaka, M

    2002-01-01

    Measurements of longitudinal bunch length of subpicosecond and picosecond electron beams have been performed by three methods with three radiation sources at the 35 MeV S-band twin liner accelerators at Nuclear Engineering Research Laboratory, University of Tokyo. The methods we adopt are the femtosecond streak camera with a nondispersive reflective optics, the coherent transition radiation (CTR) Michelson interferometer and the 10 ch polychromator that detects the spectrum of CTR and coherent diffraction radiation (CDR). The measurements by the two CTR methods were independently done with the streak camera and their results were consistent with one another. As a result, the reliability of the polychromator for the diagnostics of less than picosecond electron bunch and the usefulness of the diagnostics for the single shot measurement were verified. Furthermore, perfect nondestructive diagnostics for subpicosecond bunches was performed utilizing CDR interferometry. Then the good agreement between CDR interfero...

  18. Feasibility of producing insulation boards from oil palm fronds and empty Fruit bunches

    Directory of Open Access Journals (Sweden)

    Tanasri Sihabut

    2010-03-01

    Full Text Available This research focused on the feasibility of producing insulation boards made from oil palm fronds and empty fruit bunches via the wet forming process. Results confirmed no difference in the visual appearance between both board types. Both displayed low thermal conductivity, offering evidence of being good insulators. Boards made from empty fruit bunch weighed less than boards made from oil palm fronds. Other properties such as fire retardant, water absorption and strength still need to be investigated.

  19. Feasibility of producing insulation boards from oil palm fronds and empty Fruit bunches

    OpenAIRE

    Tanasri Sihabut; Nikhom Laemsak

    2010-01-01

    This research focused on the feasibility of producing insulation boards made from oil palm fronds and empty fruit bunches via the wet forming process. Results confirmed no difference in the visual appearance between both board types. Both displayed low thermal conductivity, offering evidence of being good insulators. Boards made from empty fruit bunch weighed less than boards made from oil palm fronds. Other properties such as fire retardant, water absorption and strength still need to be inv...

  20. Electric and Magnetic Fields Generated by a Charged Bunch between Parallel Conducting Plates

    Directory of Open Access Journals (Sweden)

    B. Levchenko

    2010-01-01

    Full Text Available Image fields generated by a bunch of charged particles between two parallel perfectly conducting plates are studied in detail. We derive exact analytical expressions for external fields of a charged relativistic bunch with a circular cross-section. Summation of image fields by the direct method invented by Laslett allows the infinite series to be represented in terms of elementary trigonometric functions.

  1. MD468: Electron Cloud Reference Fills and Dependence on the Bunch Intensity

    CERN Document Server

    Iadarola, Giovanni; Mether, Lotta; Romano, Annalisa; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2017-01-01

    This note describes a Machine Development session performed to investigate the dependence of e-cloud build-up and instabilities on the bunch population of the circulating beam. Three fills were performed with identical filling schemes and RF settings and with different injected bunch intensities. The fill with the largest intensity has also been used as a reference to assess the scrubbing evolution during 2016.

  2. Effective composting of empty fruit bunches using potential Trichoderma strains.

    Science.gov (United States)

    Siddiquee, Shafiquzzaman; Shafawati, Saili Nur; Naher, Laila

    2017-03-01

    Oil palm fibres are easy to degrade, eco-friendly in nature and once composted, they can be categorized under nutrient-enriched biocompost. Biocompost is not only a good biofertilizer but also a good biocontrol agent against soil-borne pathogens. In this research, experimental works on the composting of empty fruit bunches (EFB) from the oil palm industry were conducted using two potential Trichoderma strains. Analysis of pH initially found the soils to be slightly acidic. However, after composting, the soils were found to be alkaline. Trichoderma propagules increased by 72% in the soils compared to other fungi. Soil electrical conductivity was found to be 50.40 μS/cm for compost A, 42.10 μS/cm for compost B and 40.11 μS/cm for the control. The highest C:N ratio was obtained for compost A at 3.33, followed by compost B at 2.79, and then the control at 1.55. The highest percentages of nitrogen (N), phosphorus (P), and potassium (K) were found in compost A (0.91:2.13:6.68), which was followed by compost B (0.46:0.83:5.85) and then the control (0.32:0.26:5.76). Thus, the biocomposting of oil palm fibres shows great potential for enhancing soil micronutrient, plant growth performance, and crop yield production.

  3. Effective composting of empty fruit bunches using potential Trichoderma strains

    Directory of Open Access Journals (Sweden)

    Shafiquzzaman Siddiquee

    2017-03-01

    Full Text Available Oil palm fibres are easy to degrade, eco-friendly in nature and once composted, they can be categorized under nutrient-enriched biocompost. Biocompost is not only a good biofertilizer but also a good biocontrol agent against soil-borne pathogens. In this research, experimental works on the composting of empty fruit bunches (EFB from the oil palm industry were conducted using two potential Trichoderma strains. Analysis of pH initially found the soils to be slightly acidic. However, after composting, the soils were found to be alkaline. Trichoderma propagules increased by 72% in the soils compared to other fungi. Soil electrical conductivity was found to be 50.40 μS/cm for compost A, 42.10 μS/cm for compost B and 40.11 μS/cm for the control. The highest C:N ratio was obtained for compost A at 3.33, followed by compost B at 2.79, and then the control at 1.55. The highest percentages of nitrogen (N, phosphorus (P, and potassium (K were found in compost A (0.91:2.13:6.68, which was followed by compost B (0.46:0.83:5.85 and then the control (0.32:0.26:5.76. Thus, the biocomposting of oil palm fibres shows great potential for enhancing soil micronutrient, plant growth performance, and crop yield production.

  4. Stochastic cooling of bunched beams from fluctuation and kinetic theory

    Energy Technology Data Exchange (ETDEWEB)

    Chattopadhyay, S.

    1982-09-01

    A theoretical formalism for stochastic phase-space cooling of bunched beams in storage rings is developed on the dual basis of classical fluctuation theory and kinetic theory of many-body systems in phase-space. The physics is that of a collection of three-dimensional oscillators coupled via retarded nonconservative interactions determined by an electronic feedback loop. At the heart of the formulation is the existence of several disparate time-scales characterizing the cooling process. Both theoretical approaches describe the cooling process in the form of a Fokker-Planck transport equation in phase-space valid up to second order in the strength and first order in the auto-correlation of the cooling signal. With neglect of the collective correlations induced by the feedback loop, identical expressions are obtained in both cases for the coherent damping and Schottky noise diffusion coefficients. These are expressed in terms of Fourier coefficients in a harmonic decomposition in angle of the generalized nonconservative cooling force written in canonical action-angle variables of the particles in six-dimensional phase-space. Comparison of analytic results to a numerical simulation study with 90 pseudo-particles in a model cooling system is presented.

  5. Early transverse decoherence of bunches with space charge

    Directory of Open Access Journals (Sweden)

    Ivan Karpov

    2016-12-01

    Full Text Available The transverse decoherence of injected bunches is an important phenomenon in synchrotrons and storage rings. The initial stage of this process determines the transverse emittance blowup, which should be taken into account for the design of feedback systems, for example. The interplay of different high-intensity effects can strongly affect the initial decoherence stage. We present a model that explains decoherence and emittance growth with chromaticity, space charge, and image charges within the first synchrotron period. We compare the model for different combinations of parameters with self-consistent particle tracking simulations and measurements in the SIS18 synchrotron at GSI Darmstadt. Generally, space charge slows down the decoherence process and can cause the loss of decoherence. Chromaticity and image charges can partly compensate this loss and restore the decoherence. We also analyze the single-particle excitation driven by space charge during the decoherence process. Particles gain large amplitudes from the coherent beam oscillation, which leads to halo buildup and losses.

  6. Short electron bunches generated by perpendicularly crossing laser pulses

    Science.gov (United States)

    Horný, Vojtěch; Petržílka, Václav; Klimo, Ondřej; Krůs, Miroslav

    2017-10-01

    Optical injection of electrons into a laser wakefield accelerator by a low intensity orthogonally colliding laser pulse is investigated using 2D particle-in-cell simulations. The collision of the main laser pulse driving the plasma wave in the cavitated regime and the low intensity injection pulse affects the trajectories of electrons in the crossing region. As a consequence, some electrons are ejected into the front part of the bubble, and these electrons are subsequently trapped in the rear part of the bubble. The injected and accelerated electron bunch reaches a peak energy of 630 MeV after 8 ps of acceleration being as short as 7.0 fs and is quasimonoenergetic with a low energy spread of 20 MeV (3.8%), having a charge of several dozens of pC and a relatively large emittance of 2.27 π . mm . mrad. Two main injection mechanisms—crossing beatwave injection and injection by laser field preacceleration—were identified.

  7. Bioplastic production from cellulose of oil palm empty fruit bunch

    Science.gov (United States)

    Isroi; Cifriadi, A.; Panji, T.; Wibowo, Nendyo A.; Syamsu, K.

    2017-05-01

    Empty fruit bunch is available abundantly in Indonesia as side product of CPO production. EFB production in Indonesia reached 28.65 million tons in 2015. EFB consist of 36.67% cellulose, 13.50% hemicellulose and 31.16% lignin. By calculation, potential cellulose from EFB is 11.50 million tons. Cellulose could be utilized as source for bioplastic production. This research aims to develop bioplastic production based on cellulose from EFB and to increase added value of EFB. Cellulose fiber has no plastic properties. Molecular modification of cellulose, composite with plasticizer and compatibilizer is a key success for utilization of cellulose for bioplastic. Main steps of bioplastic production from EFB are: 1) isolation and purification of cellulose, 2) cellulose modification and 3) synthesis of bioplastic. Cellulose was isolated by sodium hydroxide methods and bleached using sodium hypochlorite. Purity of obtained cellulose was 97%. Cellulose yield could reach 30% depend on cellulose content of EFB. Cellulose side chain was oxidized to reduce hydroxyl group and increase the carboxyl group. Bioplastic synthesis used glycerol as plasticizer and cassava starch as matrix. This research was successfully producing bioplastic sheet by casting method. In future prospects, bioplastic from EFB cellulose can be developed as plastic bag and food packaging.

  8. Temporal intensity interferometry: photon bunching in three bright stars

    Science.gov (United States)

    Guerin, W.; Dussaux, A.; Fouché, M.; Labeyrie, G.; Rivet, J.-P.; Vernet, D.; Vakili, F.; Kaiser, R.

    2017-12-01

    We report the first intensity correlation measured with starlight since the historical experiments of Hanbury Brown and Twiss. The photon bunching g(2)(τ, r = 0), obtained in the photon-counting regime, was measured for three bright stars: α Boo, α CMi and β Gem. The light was collected at the focal plane of a 1-m optical telescope, transported by a multi-mode optical fibre, split into two avalanche photodiodes and correlated digitally in real time. For total exposure times of a few hours, we obtained contrast values around 2 × 10-3, in agreement with the expectation for chaotic sources, given the optical and electronic bandwidths of our set-up. Comparing our results with the measurement of Hanbury Brown et al. for α CMi, we argue for the timely opportunity to extend our experiments to measuring the spatial correlation function over existing and/or foreseen arrays of optical telescopes diluted over several kilometres. This would enable microarcsec long-baseline interferometry in the optical, especially in the visible wavelengths, with a limiting magnitude of 10.

  9. Spectral reflectance of oil-palm (Elaeis guineensis Jacq. bunches as indicator for optimal harvesting

    Directory of Open Access Journals (Sweden)

    Wunsri, S.

    2005-12-01

    Full Text Available To determine the appropriate harvesting time of Tenera oil palm bunches, the spectral reflectance of ripening bunches was investigated from images taken by a digital Canon PowerShot A20 camera. Every second day images were taken from selected bunches at an oil-palm estate during the growth of the bunchesfrom immaturity to the over-ripe phase, to trace the changes in color which correlate with the process of ripening. The images were analyzed measuring the changes in the three basic colors red, green and blue, using a specially developed Color Analysis computer program for Oil-palm 'fruit' (CAOP, and determining the correlation with the measured palm-oil content of the nuts.Of the three color-bands, the red light reflectance showed the best correlation with ripeness, as the red color increased regularly and practically linearly up to the stage of the maximal oil yield. Some seven days after the thus determined optimal harvesting date for the ripe bunches, some of the ripe nuts will detachfrom the bunch and fall, but then it is too late to use the fallen nuts as indicators for harvesting. From our investigations in the field and in the laboratory we recommend that harvesting should follow immediately after the red reflectance starts declining, after having reached its peak value for the Tenera oil-palm some 5±3 days before nuts begin to detach from the bunch.

  10. A coupled bunch instability due to beam-photoelectron interactions in KEKB-LER

    Energy Technology Data Exchange (ETDEWEB)

    Ohmi, Kazuhito [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1996-08-01

    LER of KEKB is designed to storage the positron beam of 2.6 A with multibunch operation. Nb = 3.3 x 10{sup 10} positrons are filled in a bunch and the bunch passes every 2ns through a beam chamber. The photoelectron instability may be serious for KEKB-LER. We consider a motion of photoelectrons produced by a bunch with a computer simulation technic. A cylindrical chamber with a diameter of 10 cm was used as a model chamber. About 15 times of the photoelectrons were produced by a bunch. The wake force was calculated for the loading bunches with displacements of 0.5 mm and 1 mm. The wake characteristics seems to be caused by the trapped electrons kicked by the loading bunch. The wake was saturated with the loading displacement of 0.5 mm. We obtained a growth rate by the wake force. It is very high rate, 2500s{sup -1} which exceeds damping rates of various mechanism, radiation, head-tail and feedback. Perhaps it is essential to remove the photoelectrons around the positron beam explicitly. If we apply magnetic field fo about 20 G, the growth rate will be reduced. (S.Y.)

  11. Calculating the Loss factor of the LCLS Beam Line Elements for Ultra-Shrot Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Novokhatski, A.; /SLAC

    2009-10-17

    The Linac Coherent Light Source (LCLS) is a SASE 1.5-15 {angstrom} x-ray Free-Electron Laser (FEL) facility. Since an ultra-short intense bunch is used in the LCLS operation one might suggest that wake fields, generated in the vacuum chamber, may have an effect on the x-ray production because these fields can change the beam particle energies thereby increasing the energy spread in a bunch. At LCLS a feedback system precisely controls the bunch energy before it enters a beam transport line after the linac. However, in the transport line and later in the undulator section the bunch energy and energy spread are not under feedback control and may change due to wake field radiation, which depends upon the bunch current or on a bunch length. The linear part of the energy spread can be compensated in the upstream linac; the energy loss in the undulator section can be compensated by varying the K-parameter of the undulators, however we need a precise knowledge of the wake fields in this part of the machine. Resistive wake fields are known and well calculated. We discuss an additional part of the wake fields, which comes from the different vacuum elements like bellows, BPMs, transitions, vacuum ports, vacuum valves and others. We use the code 'NOVO' together with analytical estimations for the wake potential calculations.

  12. Bunch Current Measurement Using a High-Speed Photodetector at HLS II

    Science.gov (United States)

    Zhou, Tianyu; Yang, Yongliang; Sun, Baogen; Lu, Ping; Wu, Fangfang; Wang, Jigang; Zhou, Zeran; Luo, Qing; Wang, Qian; Li, Hao

    2017-07-01

    This paper presents a novel bunch current measurement system based on an ultrafast photodetector and a high-speed digitizer at Hefei light source II (HLS II). We use a metal-semiconductor-metal photodetector to measure the emitted optical synchrotron radiation intensity directly, representing the bunch current intensity. To achieve bunch-by-bunch resolution, the sampling rate of the system is nearly 225 GS/s, which is achieved via a dedicated equivalent sampling algorithm. The detailed description of the experimental setup and the equivalent sampling algorithm are presented. According to preliminary tests of the daily operation mode and single-bunch mode, the measured root-mean-square of the beam current is 1%, which shows that the new system satisfies the requirements for high-precision bunch current measurements. In addition, experimental results of the “HLS” Morse-code fill pattern mode demonstrate that this system could also be a convenient and robust tool for beam top-up modes in the future.

  13. Calculation of coupled bunch effects in the synchrotron light source BESSY VSR

    Energy Technology Data Exchange (ETDEWEB)

    Ruprecht, Martin

    2016-02-22

    In the scope of this thesis, the strength of coupled bunch instabilities (CBIs) driven by longitudinal monopole higher order modes (HOMs) and transverse dipole and quadrupole HOMs is evaluated for the upgrade project BESSY Variable Pulse Length Storage Ring (BESSY VSR) at Helmholtz-Zentrum Berlin fuer Materialien und Energie GmbH (HZB), based on analytic calculations and tracking simulations, and compared to the performance of an active bunch-by-bunch feedback (BBFB). Algorithms for tracking codes are derived, and a semi-empirical formula for the estimation of transverse quadrupole CBIs is presented. CBI studies are an integral part of the benchmarking of the cavity models for BESSY VSR and have been accompanying and influencing their entire design process. Based on the BESSY VSR cavity model with highly advanced HOM damping, beam stability is likely to be reached with a BBFB system, independent of the bunch fill pattern. Additionally, measurements of CBIs have been performed at BESSY II and the Metrology Light Source of the Physikalisch-Technische Bundesanstalt (MLS), where the longitudinal long range impedance was characterized. Transient beam loading is evaluated by means of analytic formulas and new experimentally verified tracking codes. For the baseline bunch fill pattern of BESSY VSR, it is shown that the particular setup of cavity frequencies amplifies the transient effect on the long bunch, limiting its elongation and potentially resulting in increased Touschek losses.

  14. Seeding of self-modulation instability of a long electron bunch in a plasma.

    Science.gov (United States)

    Fang, Y; Yakimenko, V E; Babzien, M; Fedurin, M; Kusche, K P; Malone, R; Vieira, J; Mori, W B; Muggli, P

    2014-01-31

    We demonstrate experimentally that a relativistic electron bunch shaped with a sharp rising edge drives plasma wakefields with one to seven periods along the bunch as the plasma density is increased. The plasma density is varied in the 10(15)-10(17)  cm(-3) range. The wakefields generation is observed after the plasma as a periodic modulation of the correlated energy spectrum of the incoming bunch. We choose a low bunch charge of 50 pC for optimum visibility of the modulation at all plasma densities. The longitudinal wakefields creating the modulation are in the MV/m range and are indirect evidence of the generation of transverse wakefields that can seed the self-modulation instability, although the instability does not grow significantly over the short plasma length (2 cm). We show that the seeding provides a phase reference for the wakefields, a necessary condition for the deterministic external injection of a witness bunch in an accelerator. This electron work supports the concept of similar experiments in the future, e.g., SMI experiments using long bunches of relativistic protons.

  15. Experimental observation of constructive superposition of wakefields generated by electron bunches in a dielectric-lined waveguide

    Directory of Open Access Journals (Sweden)

    S. V. Shchelkunov

    2006-01-01

    Full Text Available We report results from an experiment that demonstrates the successful superposition of wakefields excited by 50 MeV bunches which travel ∼50  cm along the axis of a cylindrical waveguide which is lined with alumina. The bunches are prepared by splitting a single laser pulse prior to focusing it onto the cathode of an rf gun into two pulses and inserting an optical delay in the path of one of them. Wakefields from two short (5–6 psec 0.15–0.35 nC bunches are superimposed and the energy loss of each bunch is measured as the separation between the bunches is varied so as to encompass approximately one wakefield period (∼21   cm. A spectrum of ∼40   TM_{0m} eigenmodes is excited by the bunch. A substantial retarding wakefield (2.65   MV/m·nC for just the first bunch is developed because of the short bunch length and the narrow vacuum channel diameter (3 mm through which they move. The energy loss of the second bunch exhibits a narrow peak when the bunch spacing is varied by only 4 mm (13.5 psec. This experiment is compared with a related experiment reported by a group at the Argonne National Laboratory where the bunch spacing was not varied and a much weaker retarding wakefield (∼0.1   MV/m·nC for the first bunch comprising only about 10 eigenmodes was excited by a train of long (∼9   mm bunches.

  16. Holographic Spectroscopy for Rapid Electron Bunch Analysis: Development of an Instrument with THZ Resolved Optical Gating

    Energy Technology Data Exchange (ETDEWEB)

    Sievers, Albert

    2011-10-28

    The main thrust of our project was to apply the concepts of holographic spectroscopy, developed earlier in the visible and near IR spectral regions for satellite mapping, to the THz region in order to measure the spectral signature of the coherent radiation emanating from a relativistic electron bunch to obtain the bunch length itself. There were four major discoveries. (1) In the course of this ground-breaking work we developed and built the first static THz interferometer suitable for the realization of such a holographic Fourier transform spectrometer. Experimental tests and analysis of the observed results have provided the necessary foundation for future development of THz detector arrays optimized for spectroscopic applications. (2) Since such detectors do not exist at the present time our next effort was to find an alternative approach. We explored the electro-optic (EO) detection of the THz pulse using the short pulse of a visible diode laser synchronized to the bunch with the long-term goal aimed at single bunch measurement capability. The main hurdle was found to be the parasitic scattering of the diode radiation in the EO medium. By using the optical Fourier transform of the THz interference pattern the effects of this background were suppressed enough to obtain the spectrum using multiple shot acquisition. During our experiments at the FLASH facility at DESY we determined that for single bunch measurement capability the diode laser has to be able to produce sub 100 ps pulses with peak power of at least 1 W. Since these parameters are quite feasible at the current stage of diode laser science this combination of techniques can be used for single shot measurement of a short electron bunch. (3) In carrying out the above effort a simpler measurement possibility was uncovered involving the visible/nearIR pulse of incoherent radiation produced by the same bunch. This observation made possible the cross-correlation of the THz coherent and visible incoherent

  17. Effect of temperature on pyrolysis product of empty fruit bunches

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Aizuddin Abdul; Sulaiman, Fauziah; Abdullah, Nurhayati [School of Physics, Universiti Sains Malaysia, 11800 Minden, Penang (Malaysia)

    2015-04-24

    Pyrolysis of empty fruit bunches (EFB) was performed in a fixed bed reactor equipped with liquid collecting system. Pyrolysis process was conducted by varying the terminal pyrolysis temperature from 300 to 500°C under heating rate of 10°C/min for at least 2 hours. Char yield was obtained highest at 300°C around 55.88 wt%, and started to decrease as temperature increase. The maximum yield of pyrolysis liquid was obtained around 54.75 wt% as pyrolysis temperature reach 450°C. For gas yield percentage, the yield gained as temperature was increased from 300 to 500°C, within the range between 8.44 to 19.32 wt%. The char obtained at 400°C has great potential as an alternative solid fuel, due to its high heating value of 23.37 MJ/kg, low in volatile matter and ash content which are approximately around 40.32 and 11.12 wt%, respectively. The collected pyrolysis liquid within this temperature range found to have high water content of around 16.15 to 18.20 wt%. The high aqueous fraction seemed to cause the pyrolysis liquid to have low HHV which only ranging from 10.81 to 12.94 MJ/kg. These trends of results showed that necessary enhancement should be employ either on the raw biomass or pyrolysis products in order to approach at least the minimum quality of common hydrocarbon solid or liquid fuel. For energy production, both produced bio-char and pyrolysis liquid are considered as sustainable sources of bio-energy since they contained low amounts of nitrogen and sulphur, which are considered as environmental friendly solid and liquid fuel.

  18. Sensitivity Studies with the SPS Rest Gas Profile Monitor

    CERN Document Server

    Ferioli, G; Koopman, J; Sillanoli, M

    2001-01-01

    During the SPS run in the year 2000 further test measurements were performed with the rest gas monitor. First, profiles of single circulating proton bunches were measured and the bunch charge progressively reduced, in order to determine the smallest bunch intensity which can be scanned under the present operating conditions. The image detector in this case was a CMOS camera. Using a multi-anode strip photo-multiplier with fast read-out electronics, the possibility to record profiles on a single beam passage and on consecutive turns was also investigated. This paper presents the results of these tests and discusses the expected improvements for the operation in 2001. Moreover, the issue of micro channel plate ageing effects was tackled and a calibration system based on electron emission from a heating wire is proposed. The gained experience will be used for the specification of a new monitor with optimised design, to be operated both in the SPS and in the LHC.

  19. Spectral reflectance analysis of longkong (Lansium domesticum Corr. bunches as an indicator for optimal harvesting

    Directory of Open Access Journals (Sweden)

    Kaewtubtim, P.

    2007-09-01

    Full Text Available To determine the appropriate harvesting time of Longkong bunches, the spectral reflectance of ripening bunches was investigated from images taken by a digital camera using red LED and green LED. Every day images were taken from selected bunches at a Longkong estate during the growth of the bunches from immaturity to the over-ripe phase, to trace the changes in color that correlate with the process of ripening. The images were analyzed by measuring the changes in the three basic colors i.e. red, green and blue, using a specially developed Color Analysis computer program of Longkong "fruit" (CAOL, and then the obtained results were compared with the sweet in form of total soluble solid (TSS:TA.The result showed that the blue light reflectance from red LED source (Br was selected as an indicator for harvesting Longkong bunches. Br was inversely proportional to ripeness of Longkong. The blue color intensity decreases linearly while TSS:TA increases monotonously. From our investigations, we suggest that the time interval to harvest Longkong should be within 96 ±7 days after the first flower blossom of that bunch takes place while blue level per pixel was in the range of 8.67-2.39. If Longkong bunch was cut while the blue color level was in the range of 8.67-5.53, its taste will be sweet and sour and strong enough for long distance shipment. But if the blue level per pixel was in the range of 5.52-2.39, it has a very good taste and is suitable a for sale in the local area. In addition, it was also found that the blue level per pixel usually decreased at the rate of 0.45 per day. This made is possible to predict the harvesting day by this technique.

  20. Beamlet laser diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Burkhart, S.C.; Behrendt, W.C.; Smith, I.

    1996-06-01

    Beamlet is instrumented extensively to monitor the performance of the overall laser system and many of its subsystems. Beam diagnostics, installed in key locations, are used to fully characterize the beam during its propagation through the multipass cavity and the laser`s output section. This article describes the diagnostics stations located on Beamlet and discusses the design, calibration, and performance of the Beamlet calorimeters. The authors used Nova`s diagnostics packages to develop the Beamlet design to determine beam energy, spatial profile, temporal profile, and other beam parameters. Technologic improvements within the last several years in controls, charge-coupled device (CCD) cameras, and fast oscilloscopes have allowed the authors to obtain more accurate measurements on the Beamlet laser system. They briefly cover some of these techniques, including a description of their LabVIEW based data acquisition system.

  1. Self-consistent simulations and analysis of the coupled-bunch instability for arbitrary multibunch configurations

    Directory of Open Access Journals (Sweden)

    Gabriele Bassi

    2016-02-01

    Full Text Available A novel algorithm for self-consistent simulations of long-range wakefield effects has been developed and applied to the study of both longitudinal and transverse coupled-bunch instabilities at NSLS-II. The algorithm is implemented in the new parallel tracking code space (self-consistent parallel algorithm for collective effects discussed in the paper. The code is applicable for accurate beam dynamics simulations in cases where both bunch-to-bunch and intrabunch motions need to be taken into account, such as chromatic head-tail effects on the coupled-bunch instability of a beam with a nonuniform filling pattern, or multibunch and single-bunch effects of a passive higher-harmonic cavity. The numerical simulations have been compared with analytical studies. For a beam with an arbitrary filling pattern, intensity-dependent complex frequency shifts have been derived starting from a system of coupled Vlasov equations. The analytical formulas and numerical simulations confirm that the analysis is reduced to the formulation of an eigenvalue problem based on the known formulas of the complex frequency shifts for the uniform filling pattern case.

  2. Fast digital transverse feedback system for bunch train operation in CESR

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, J.T.; Billing, M.G.; Dobbins, J.A. [Cornell Univ., Ithaca, NY (United States). Lab. of Nuclear Studies] [and others

    1996-08-01

    We have developed a time domain transverse feedback system with the high bandwidth needed to control transverse instabilities when the CESR e{sup +}e{sup -} collider is filled with trains of closely spaced bunches. This system is based on parallel digital processors and a stripline driver. It is capable of acting on arbitrary patterns of bunches having a minimum spacing of 14 ns. Several simplifying features have been introduced. A single shorted stripline kicker driven by one power amplifier is used to control both counter-rotating beams. The desired feedback phase is achieved by sampling the bunch position at a single location on two independently selectable beam revolutions. The system adapts to changes in the betatron tune, bunch pattern, or desired damping rate through the loading of new parameters into the digital processors via the CESR control system. The feedback system also functions as a fast gated bunch current monitor. Both vertical and horizontal loops are now used in CESR operation. The measured betatron damping rates with the transverse feedback system in operation are in agreement with the analytical prediction and a computer simulation developed in connection with this work. (author)

  3. Coupled bunch instability in Fermilab Booster: Longitudinal phase-space simulation

    Energy Technology Data Exchange (ETDEWEB)

    Bogacz, S.A.; Stahl, S.

    1988-06-09

    The physical presence of vacuum structures can be expressed in terms of a coupling impedance experienced by the beam. The beam environment considered here consist of parasitic higher order modes of the r.f. cavities. These resonances may have high enough Q's to allow consecutive bunches to interact through mutually induced fields. The cumulative effect of such fields as the particles pass through the cavity may be to induce a coherent buildup in synchrotron motion of the bunches, i.e., a longitudinal coupled-bunch instability. The colliding mode operation of the present generation of high energy synchrotrons and the accompanying r.f. manipulations, make considerations of individual bunch area of paramount importance. Thus, a longitudinal instability in one of a chain of accelerators, while not leading to any immediate reduction in the intensity of the beam in that accelerator, may cause such a reduction of beam quality that later operations are inhibited (resulting in a degradation performance). In this paper we employ a longitudinal phase-space tracking code (ESME) as an effective tool to simulate specific coupled bunch modes arising in a circular accelerator. One of the obvious advantages of the simulation compared to existing analytic formalisms, e.g., based on the Vlasov equation, is that it allows consideration of the instability in a self-consistent manner with respect to the changing accelerating conditions. Furthermore this scheme allows to model nonlinearities of the longitudinal beam dynamics, which are usually not tractable analytically. 5 refs., 3 figs.

  4. ''High intensity per bunch'' working group

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Third Generation Light Sources are supposed to store high intensity beams not only in many tightly spaced bunches (multibunch operation), but also in few bunch or even single lunch modes of operation, required for example for time structure experiments. Single bunch instabilities, driven by short-range wake fields, however spoil the beam quality, both longitudinally and transversely. Straightforward ways of handling them, by pushing up the chromaticity ({zeta} = {delta}Q/({delta}p/p)) for example, enabled to raise the charge per bunch, but to the detriment of beam lifetime. In addition, since the impedance of the vacuum chamber deteriorates with the installation of new insertion devices, the current thresholds tend to dope down continuously. The goal of this Working Group was then to review these limitations in the existing storage rings, where a large number of beam measurements have been performed to characterise them, and to discuss different strategies which are used against them. About 15 different laboratories reported on the present performance of storage rings, experiences gained in high charge per bunch, and on simulation results and theoretical studies. More than 25 presentations addressed the critical issues and stimulated the discussion. Four main topics came out: - Observation and experimental data; - Impedance studies and tracking codes; - Theoretical investigations; - Cures and feedback. (author)

  5. A 4 GS/sec Instability Feedback Processing System for Intra-bunch Instabilities

    CERN Document Server

    Dusatko, J; Fox, J D; Pollock, K; Rivetta, C H; Turgut, O; Hofle, W

    2013-01-01

    We present the architecture and implementation overview of a proof-of-principle digital signal processing system developed to study control of Electron-Cloud and Transverse Mode Coupling Instabilities (TMCI) in the CERN SPS. This system is motivated by intensity increases planned as part of the High Luminosity LHC upgrade. It is based on a reconfigurable processing architecture which samples intra-bunch motion and applies correction signals at a 4GSa/s rate, allowing multiple samples across a single 3.2ns SPS bunch. This initial demonstration system is a rapidly developed prototype consisting of both commercial and custom- designed hardware that implements feedback control on a single bunch. It contains a high speed ADC and DAC, capable of sampling at up to 4GSa/s, with a 16-tap FIR control filter for each bunch sample slice. Other system features include a timing subsystem to synchronize the sampling to the injection and the bunch 1 markers, the capability of generating arbitrary time domain signals to drive...

  6. Probing intensity limits of LHC-Type bunches in CERN SPS with nominal optics

    CERN Document Server

    Adrian, G; Andujar, O; Argyropoulos, T; Axensalva, J; Baldy, J; Bartosik, H; Cettour Cave, S; Chapuis, F; Comblin, JF; Cornelis, K; Cotte, D; Cunnington, K; Damerau, H; Delrieux, M; Duran-Lopez, JL; Esteban Mueller, J; Findlay, A; Fleuret, J; Follin, F; Freyermuth, P; Genoud, H; Gilardoni, S; Guerrero, A; Hancock, S; Hanke, K; Hans, O; Hazelaar, R; Höfle, W; Jensen, L; Kuczerowski, J; Le Borgne, Y; Maillet, R; Manglunki, D; Massot, S; Matli, E; Métral, G; Métral, E; Mikulec, B; Nonglaton, JM; Ovalle, E; Papaphilippou, Y; Pereira, L; Peters, F; Rey, A; Ridewood, J; Rumolo, G; Salvant, B; Sanchez Alvarez, JL; Shaposhnikova, E; Steerenberg, R; Steinhagen, R; Tan, J; Vandorpe, B; Veyrunes, E

    2011-01-01

    Some of the upgrade scenarios of the high-luminosity LHC require large intensity per bunch from the injector chain. Single bunch beams with intensities of up to 3.5 to 4e11 p/b and nominal emittances were successfully produced in the PS Complex and delivered to the SPS in 2010. This contribution presents results of studies with this new intense beam in the SPS to probe single bunch intensity limitations with nominal gamma transition. In particular, the vertical Transverse Mode Coupling Instability (TMCI) threshold with low chromaticity was observed at 1.6e11 p/b for single nominal LHC bunches in the SPS. With increased vertical chromaticity, larger intensities could be injected, stored along the flat bottom and accelerated up to 450 GeV/c. However, significant losses and/or transverse emittance blow up were then observed. Longitudinal and transverse optimization efforts in the PSB, PS and SPS were put in place to minimize this beam degradation and succeeded to obtain single 2.5e11 p/b LHC type bunches with sa...

  7. Measurement and analysis of SPS kicker magnet heating and outgassing with Different Bunch Spacing

    CERN Document Server

    Barnes, M J; Cornelis, K; Ducimetière, L; Mahner, E; Papotti, G; Rumolo, G; Senaj, V; Shaposhnikova, E

    2010-01-01

    Fast kicker magnets are used to inject beam into and eject beam out of the CERN SPS accelerator ring. These kickers are generally ferrite loaded transmission line type magnets with a rectangular shaped aperture through which the beam passes. Unless special precautions are taken the impedance of the ferrite yoke can provoke significant beam induced heating, over several hours, even above the Curie temperature of the ferrite. At present the nominal bunch spacing in the SPS is 25 ns, however for an early stage of LHC operation it is preferable to have 50 ns bunch spacing. Machine Development (MD) studies have been carried out with an inter-bunch spacing of 25 ns, 50 ns or 75 ns. For some of the SPS kicker magnets the 75 ns bunch spacing resulted in considerable beam induced heating. In addition the MDs showed that 50 ns bunch spacing could result in a very rapid pressure rise in the kicker magnet and thus cause an interlock. This paper discusses the MD observations of the SPS kickers and analyses the available d...

  8. Space-charge effects in ultrahigh current electron bunches generated by laser-plasma accelerators

    Directory of Open Access Journals (Sweden)

    F. J. Grüner

    2009-02-01

    Full Text Available Recent advances in laser-plasma accelerators, including the generation of GeV-scale electron bunches, enable applications such as driving a compact free-electron laser (FEL. Significant reduction in size of the FEL is facilitated by the expected ultrahigh peak beam currents (10–100 kA generated in laser-plasma accelerators. At low electron energies such peak currents are expected to cause space-charge effects such as bunch expansion and induced energy variations along the bunch, potentially hindering the FEL process. In this paper we discuss a self-consistent approach to modeling space-charge effects for the regime of laser-plasma-accelerated ultracompact electron bunches at low or moderate energies. Analytical treatments are considered as well as point-to-point particle simulations, including the beam transport from the laser-plasma accelerator through focusing devices and the undulator. In contradiction to non-self-consistent analyses (i.e., neglecting bunch evolution, which predict a linearly growing energy chirp, we have found the energy chirp reaches a maximum and decreases thereafter. The impact of the space-charge induced chirp on FEL performance is discussed and possible solutions are presented.

  9. Infrared Spectroscope for Electron Bunch-length Measurement: Heat Sensor Parameters Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Domgmo-Momo, Gilles; /Towson U. /SLAC

    2012-09-05

    The Linac Coherent Light Source (LCLS) is used for many experiments. Taking advantage of the free electron laser (FEL) process, scientists of various fields perform experiments of all kind. Some for example study protein folding; other experiments are more interested in the way electrons interact with the molecules before they are destroyed. These experiments among many others have very little information about the electrons x-ray produced by the FEL, except that the FEL is using bunches less than 10 femtoseconds long. To be able to interpret the data collected from those experiments, more accurate information is needed about the electron's bunch-length. Existing bunch length measurement techniques are not suitable for the measurement of such small time scales. Hence the need to design a device that will provide more precise information about the electron bunch length. This paper investigates the use of a pyreoelectric heat sensor that has a sensitivity of about 1.34 micro amps per watt for the single cell detector. Such sensitivity, added to the fact that the detector is an array sensor, makes the detector studied the primary candidate to be integrated to an infrared spectrometer designed to better measure the LCLS electron bunch length.

  10. Bunch decompression for laser-plasma driven free-electron laser demonstration schemes

    Directory of Open Access Journals (Sweden)

    T. Seggebrock

    2013-07-01

    Full Text Available X-ray free-electron lasers (FELs require a very high electron beam quality in terms of emittance and energy spread. Since 2004 high quality electrons produced by laser-wakefield accelerators have been demonstrated, but the electron quality up to now did not allow the operation of a compact x-ray FEL using these electrons. Maier et al. [Phys. Rev. X 2, 031019 (2012PRXHAE2160-330810.1103/PhysRevX.2.031019] suggested a concept for a proof-of-principle experiment allowing FEL operation in the vacuum ultraviolet range based on an optimized undulator and bunch decompression using electron bunches from a laser-plasma accelerator as currently available. In this paper we discuss in more detail how a chicane can be used as a bunch stretcher instead of a bunch compressor to allow the operation of a laser-wakefield accelerator driven FEL using currently available electrons. A scaling characterizing the impact of bunch decompression on the gain length is derived and the feasibility of the concept is tested numerically in a demanding scenario.

  11. Relativistic attosecond electron bunch emission from few-cycle laser irradiated nanoscale droplets

    Directory of Open Access Journals (Sweden)

    Laura Di Lucchio

    2015-02-01

    Full Text Available Attosecond electron bunches produced at the surface of nanometer-scale droplets illuminated by a two-cycle laser pulse are investigated for the purpose of determining their optimal emission characteristics. Significant departures from Mie theory are found for electron bunch emission from droplets whose radii satisfy the condition δ_{r}bunches is to a good approximation described by the nonlinear ponderomotive scattering model. Subsequently, the bunches are subject to further deflection by the ponderomotive pressure of the copropagating laser field in vacuum, depending on the initial droplet parameters. Final emission angles are estimated, together with the energy spectrum of the bunches.

  12. Ion Emittance Growth Due to Focusing Modulation from Slipping Electron Bunch

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2015-02-17

    Low energy RHIC operation has to be operated at an energy ranging from γ = 4.1 to γ = 10. The energy variation causes the change of revolution frequency. While the rf system for the circulating ion will operate at an exact harmonic of the revolution frequency (h=60 for 4.5 MHz rf and h=360 for 28 MHz rf.), the superconducting rf system for the cooling electron beam does not have a frequency tuning range that is wide enough to cover the required changes of revolution frequency. As a result, electron bunches will sit at different locations along the ion bunch from turn to turn, i.e. the slipping of the electron bunch with respect to the circulating ion bunch. At cooling section, ions see a coherent focusing force due to the electrons’ space charge, which differs from turn to turn due to the slipping. We will try to estimate how this irregular focusing affects the transverse emittance of the ion bunch.

  13. Nonlinear δf particle simulations of collective excitations and energy-anisotropy instabilities in high-intensity bunched beams

    Directory of Open Access Journals (Sweden)

    Hong Qin

    2007-06-01

    Full Text Available Collective effects with strong coupling between the longitudinal and transverse dynamics are of fundamental importance for applications of high-intensity bunched beams. The self-consistent Vlasov-Maxwell equations are applied to high-intensity finite-length charge bunches, and a generalized δf particle simulation algorithm is developed for bunched beams with or without energy anisotropy. The nonlinear δf method exhibits minimal noise and accuracy problems in comparison with standard particle-in-cell simulations. Systematic studies are carried out under conditions corresponding to strong 3D nonlinear space-charge forces in the beam frame. For charge bunches with isotropic energy, finite bunch-length effects are clearly evident by the fact that the spectra for an infinitely long coasting beam and a nearly spherical charge bunch have strong similarities, whereas the spectra have distinctly different features when the bunch length is varied between these two limiting cases. For bunched beams with anisotropic energy, there exists no exact kinetic equilibrium because the particle dynamics do not conserve transverse energy and longitudinal energy separately. A reference state in approximate dynamic equilibrium has been constructed theoretically, and a quasi-steady state has been established in the simulations for the anisotropic case. Collective excitations relative to the reference state have been simulated using the generalized δf algorithm. In particular, the electrostatic Harris instability driven by strong energy anisotropy is investigated for a finite-length charge bunch. The observed growth rates are larger than those obtained for infinitely long coasting beams. However, the growth rate decreases for increasing bunch length to a value similar to the case of a long coasting beam. For long bunches, the instability is axially localized symmetrically relative to the beam center, and the characteristic wavelength in the longitudinal direction is

  14. Extraction of High Charge Electron Bunch from the ELSA RF Injector Comparison Between Simulation and Experiment

    CERN Document Server

    Lemaire, J; Binet, A; Lagniel, J M; Le Flanchec, V; Pichoff, N

    2004-01-01

    A new scheme based on a photoinjector and a RF linear accelerator operating at 352 MHz has been recently proposed as a versatile radiographic facility. Beam pulses of 60 ns duration contain 20 succesive electron bunches which will be extracted at 2.5 MeV from a photoinjector then accelerated through the next structure to the final energy of 51 MeV. Bunches carrying 100 nC are required for this purpose. As a first demonstrating step, 50 nC electron bunches have been produced and accelerated to 2.5 MeV with the 144 MHz ELSA photoinjector at Bruyères le Chatel. For this experiment, we compare the results and the numerical simulations made with PARMELA, MAGIC and MAFIA codes.

  15. Intrabeam scattering of lead ion LHC type bunches in the SPS

    CERN Document Server

    Vos, L

    1997-01-01

    The classical theory of intrabeam scattering by A. Piwinski [1] has been successfully applied in the past to the Sp S [2] for dense proton and anti-proton bunches. The particle radius is an important ingredient in the scattering process. This parameter becomes very large for heavy ions compared with the radius of protons and intrabeam scattering rates may become troublesome even for modest bunch populations. The injection momentum of the LHC type lead ion bunches will be below transition in the SPS. Applying the theory and computing the growth rates may produce results that are not obvious at first sight. This paper tries to shed some light on the processes involved so that the computed growth rates are less cause for wonder. It does not propose any new element in the theory but only emphasizes a few aspects to clarify intrabeam scattering of relatively dense particle beams below transition.

  16. Generation of Electron Bunches at Low Repetition Rates Using a Beat-Frequency Technique

    Energy Technology Data Exchange (ETDEWEB)

    Poelker, Matt; Grames, Joseph; Hansknecht, John; Kazimi, Reza; Musson, John

    2007-05-01

    Even at a continuous wave facility such as CEBAF at Jefferson Lab, an electron beam with long time intervals (tens of ns) between individual bunches can be useful, for example to isolate sources of background via time of flight detection or to measure the energy of neutral particles that cannot be separated with a magnetic field. This paper describes a demonstrated method to quickly and easily deliver bunches with repetition rates of 20 to 100 MHz corresponding to time intervals between 10 to 50 ns (respectively). This is accomplished by changing the ON/OFF frequency of the RF-pulsed drive laser by a small amount (f/f < 20%), resulting in a bunch frequency equal to the beat frequency between the radio frequencies of the drive laser and the photoinjector chopper system.

  17. Issues for a multi-bunch operation with SPARC C-band cavities

    CERN Document Server

    Alesini, D; Mostacci, A; Palumbo, L; Spataro, B; Vaccarezza, C

    2012-01-01

    SPARC C-band traveling wave cavities were originally designed for the SPARC energy upgrade in the single bunch operation mode. In the context of a gamma source based on Compton backscattering and based on the SPARC C-band technology, we investigated the issues related to the use of these structures in the multi-bunch operation mode. Several beam configurations have been considered and the effects of transverse and longitudinal long range wakefields on beam dynamics have been studied. In the paper we present the results of these studies and, in particular, the issues related to transverse beam break-up that could prevent the multi-bunch operation. Possible HOM damped structures are also proposed.

  18. Longitudinal wake of a bunch of suddenly accelerated electrons within the radiation formation zone

    Directory of Open Access Journals (Sweden)

    R. A. Bosch

    2007-05-01

    Full Text Available The longitudinal wake is considered for a bunch of electrons that are suddenly accelerated to an ultrarelativistic velocity. This wake describes the wake of forward transition radiation, and it approximates the edge-radiation wake of a bunch exiting a bending magnet. The wake is large within the radiation formation zone, where it provides resistive impedance. A comparison with the computed wake downstream of a bending magnet yields good agreement, indicating that our wake expressions may be used to approximate the wake without numerical computation. For schemes in which a bunch produced by laser-plasma acceleration exits the plasma and then drives a free electron laser (FEL, the transition-radiation wake causes energy losses of many MeV that may affect the FEL process.

  19. Radiation from laser accelerated electron bunches: Coherent terahertz and femtosecond X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Leemans, W.P.; Esarey, E.; van Tilborg, J.; Michel, P.A.; Schroeder, C.B.; Toth, Cs.; Geddes, C.G.R.; Shadwick, B.A.

    2004-10-01

    Electron beam based radiation sources provide electromagnetic radiation for countless applications. The properties of the radiation are primarily determined by the properties of the electron beam. Compact laser driven accelerators are being developed that can provide ultra-short electron bunches (femtosecond duration) with relativistic energies reaching towards a GeV. The electron bunches are produced when an intense laser interacts with a dense plasma and excites a large amplitude plasma density modulation (wakefield) that can trap background electrons and accelerate them to high energies. The short pulse nature of the accelerated bunches and high particle energy offer the possibility of generating radiation from one compact source that ranges from coherent terahertz to gamma rays. The intrinsic synchronization to a laser pulse and unique character of the radiation offers a wide range of possibilities for scientific applications. Two particular radiation source regimes are discussed: Coherent terahertz emission and x-ray emission based on betatron oscillations and Thomson scattering.

  20. Recent beam-beam experience with multiple high current bunches in PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Minty, M.G.

    2000-02-07

    Operation with colliding beams at PEP-II has progressed remarkably well with over half the design specific luminosity and 5.2 x 10{sup 32}cm{sup {minus}2}s{sup {minus}1} in multiple bunches demonstrated during the last commissioning period before installation of the BABAR detector. Further luminosity increases are anticipated as the vertical beam size is reduced and beam currents are raised towards design values. At high currents interesting multibunch dynamics, which depend strongly on current distribution, have been observed during single-beam commissioning studies. Transverse beam instabilities nominally controlled using bunch-by-bunch feedback were observed to be significantly suppressed, in the absence of feedback, with beams in collision.

  1. High quality electron bunch generation with CO2-laser-plasma interaction

    Science.gov (United States)

    Zhang, Lingang; Shen, Baifei; Xu, Jiancai; Ji, Liangliang; Zhang, Xiaomei; Wang, Wenpeng; Zhao, Xueyan; Yi, Longqing; Yu, Yahong; Shi, Yin; Xu, Tongjun; Xu, Zhizhan

    2015-02-01

    CO2 laser-driven electron acceleration in low-density plasma is demonstrated using particle-in-cell simulation. An intense CO2 laser pulse of long wavelength excites a wake bubble that has a large elongated volume for accelerating a large number of electrons before reaching the charge saturation limit. A transversely injected laser pulse is used to induce and control the electron injection. It is found that an electron bunch with total charge up to 10 nC and absolute energy spread less than 16 MeV can be obtained. As a result, the charge per energy interval of the bunch reaches up to 0.6 nC/MeV. Intense CO2-laser based electron acceleration can provide a new direction for generating highly charged electron bunches with low energy spread, which is of much current interest, especially for table-top X-ray generation.

  2. A Self-Adjusting Method to Resist Bus Bunching Based on Boarding Limits

    Directory of Open Access Journals (Sweden)

    Shuzhi Zhao

    2016-01-01

    Full Text Available Bus bunching is one of the most serious problems of urban bus systems. Bus bunching increases waiting and travel time of passengers. Many bus systems use schedules to reach equal headways. Compared to the idea of schedules and the target headway introduced later, we propose a new method to improve the efficiency of a bus system and avoid bus bunching by boarding limits. Our solution can be effectively implemented when buses cannot travel as planned because of bad road conditions and dynamic demands at bus stops. Besides, using our method, bus headways reach the state with equal headways dynamically and spontaneously without drivers’ explicit intervention. Moreover, the method can improve the level of the bus service and reduce total travel time of passengers. We verify our method using an ideal bus route and a real bus route, both showing the success of the proposed method.

  3. Additional measures do not improve the diagnostic accuracy of the Hospital Admission Risk Profile for detecting downstream quality of life in community-dwelling older people presenting to a hospital emergency department

    Directory of Open Access Journals (Sweden)

    Grimmer K

    2014-01-01

    Full Text Available K Grimmer, S Milanese, K Beaton, A AtlasInternational Centre for Allied Health Evidence, University of South Australia, Adelaide, SA, AustraliaIntroduction: The Hospital Admission Risk Profile (HARP instrument is commonly used to assess risk of functional decline when older people are admitted to hospital. HARP has moderate diagnostic accuracy (65% for downstream decreased scores in activities of daily living. This paper reports the diagnostic accuracy of HARP for downstream quality of life. It also tests whether adding other measures to HARP improves its diagnostic accuracy.Methods: One hundred and forty-eight independent community dwelling individuals aged 65 years or older were recruited in the emergency department of one large Australian hospital with a medical problem for which they were discharged without a hospital ward admission. Data, including age, sex, primary language, highest level of education, postcode, living status, requiring care for daily activities, using a gait aid, receiving formal community supports, instrumental activities of daily living in the last week, hospitalization and falls in the last 12 months, and mental state were collected at recruitment. HARP scores were derived from a formula that summed scores assigned to age, activities of daily living, and mental state categories. Physical and mental component scores of a quality of life measure were captured by telephone interview at 1 and 3 months after recruitment.Results: HARP scores are moderately accurate at predicting downstream decline in physical quality of life, but did not predict downstream decline in mental quality of life. The addition of other variables to HARP did not improve its diagnostic accuracy for either measure of quality of life.Conclusion: HARP is a poor predictor of quality of life.Keywords: functional decline, HARP, quality of life, older people

  4. Longitudinal phase-space manipulation of ellipsoidal electron bunches in realistic fields

    Directory of Open Access Journals (Sweden)

    S. B. van der Geer

    2006-04-01

    Full Text Available Since the recent publication of a practical recipe to create “pancake” electron bunches which evolve into uniformly filled ellipsoids, a number of papers have addressed both an alternative method to create such ellipsoids as well as their behavior in realistic fields. So far, the focus has been on the possibilities to preserve the initial “thermal” transverse emittance. This paper addresses the linear longitudinal phase space of ellipsoidal bunches. It is shown that ellipsoidal bunches allow ballistic compression at subrelativistic energies, without the detrimental effects of nonlinear space-charge forces. This in turn eliminates the need for the large correlated energy spread normally required for longitudinal compression of relativistic particle beams, while simultaneously avoiding all problems related to magnetic compression. Furthermore, the linear space-charge forces of ellipsoidal bunches can be used to reduce the remaining energy spread even further, by carefully choosing the beam transverse size, in a process that is essentially the time-reversed process of the creation of an ellipsoid at the cathode. The feasibility of compression of ellipsoidal bunches is illustrated with a relatively simple setup, consisting of a half-cell S-band photogun and a two-cell booster compressor. Detailed GPT simulations in realistic fields predict that 100 pC ellipsoidal bunches can be ballistically compressed to 100 fs, at a transverse emittance of 0.7   μm, with a final energy of 3.7 MeV and an energy spread of only 50 keV.

  5. Design of bunch compressing system with suppression of coherent synchrotron radiation for ATF upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Jing, Yichao [Brookhaven National Lab. (BNL), Upton, NY (United States); Fedurin, Mikhail [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-03

    One of the operation modes for Accelerator Test Facility (ATF) upgrade is to provide high peak current, high quality electron beam for users. Such operation requires a bunch compressing system with a very large compression ratio. The CSR originating from the strong compressors generally could greatly degrade the quality of the electron beam. In this paper, we present our design for the entire bunch compressing system that will limit the effect of CSR on the e-beam’s quality. We discuss and detail the performance from the start to end simulation of such a compressor for ATF.

  6. A longitudinal bunch monitoring system using LabVIEW and high-speed oscilloscopes

    Energy Technology Data Exchange (ETDEWEB)

    Barsotti, E.L. Jr. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, Illinois 60510 (United States)

    1995-05-05

    A new longitudinal bunch monitor system has been installed at Fermilab for the Tevatron and Main Ring. For each machine, a signal from a broadband wall current monitor is sampled and digitized by a high-speed oscilloscope. A Macintosh computer, running LabVIEW-based software, controls the scopes and CAMAC timing modules and analyzes the acquired data. The resulting bunch parameters are used for a variety of purposes, including Tevatron collider luminosity calculation and injection analysis. This paper examines the system in detail. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  7. A longitudinal bunch monitoring system using LabVIEW{reg_sign} and high-speed oscilloscopes

    Energy Technology Data Exchange (ETDEWEB)

    Barsotti, E.L.

    1994-10-01

    A new longitudinal bunch monitoring system has been installed at Fermilab for the Tevatron and Main Ring. For each machine, a signal from a broadband wall current monitor is sampled and digitized by a high-speed oscilloscope. A Macintosh computer, running LabVIEW-based software, controls the scopes and CAMAC timing modules and analyzes the acquired data. The resulting bunch parameters are used for a variety of purposes, including Tevatron collider luminosity calculation and injection analysis. This paper examines the system in detail.

  8. Simulation Study of Coupled-Bunch Instabilities due to Resistive Wall, Ions, or Electron Cloud

    CERN Document Server

    Zimmermann, Frank; Ohmi, K; Ohnishi, Y; Win, S S

    2003-01-01

    We simulate the interaction of a bunch train with either an external wake field, (semi-)trapped ions in a field-free region or in a dipole field, or an electron cloud, on successive turns, using a simplified algorithm with only a small number of macro-particles. We present simulated mode spectra and rise times for the ensuing coupled-bunch instabilities, and show that observations at the KEKB HER are consistent with a horizontal instability driven by carbon monoxide ions in a region without magnetic field.

  9. Overview of Alternative Bunching and Current-shaping Techniques for Low-Energy Electron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Piot, Philippe [Northern Illinois U.

    2015-12-01

    Techniques to bunch or shape an electron beam at low energies (E <15 MeV) have important implications toward the realization of table-top radiation sources [1] or to the design of compact multi-user free-electron lasers[2]. This paper provides an overview of alternative methods recently developed including techniques such as wakefield-based bunching, space-charge-driven microbunching via wave-breaking [3], ab-initio shaping of the electron-emission process [4], and phase space exchangers. Practical applications of some of these methods to foreseen free-electron-laser configurations are also briefly discussed [5].

  10. Centroid theory of transverse electron-proton two-stream instability in a long proton bunch

    Directory of Open Access Journals (Sweden)

    Tai-Sen F. Wang

    2003-01-01

    Full Text Available This paper presents an analytical investigation of the transverse electron-proton (e-p two-stream instability in a proton bunch propagating through a stationary electron background. The equations of motion, including damping effects, are derived for the centroids of the proton beam and the electron cloud by considering Lorentzian and Gaussian frequency spreads for the particles. For a Lorentzian frequency distribution, we derive the asymptotic solution of the coupled linear centroid equations in the time domain and study the e-p instability in proton bunches with nonuniform line densities. Examples are given for both uniform and parabolic proton line densities.

  11. Effects of correlation in transition radiation of super-short electron bunches

    Science.gov (United States)

    Danilova, D. K.; Tishchenko, A. A.; Strikhanov, M. N.

    2017-07-01

    The effect of correlations between electrons in transition radiation is investigated. The correlation function is obtained with help of the approach similar to the Debye-Hückel theory. The corrections due to correlations are estimated to be near 2-3% for the parameters of future projects SINBAD and FLUTE for bunches with extremely small lengths (∼1-10 fs). For the bunches with number of electrons about ∼ 2.5 ∗1010 and more, and short enough that the radiation would be coherent, the corrections due to correlations are predicted to reach 20%.

  12. Spectrometer for shot-to-shot photon energy characterization in the multi-bunch mode of the free electron laser at Hamburg.

    Science.gov (United States)

    Palutke, S; Gerken, N C; Mertens, K; Klumpp, S; Mozzanica, A; Schmitt, B; Wunderer, C; Graafsma, H; Meiwes-Broer, K-H; Wurth, W; Martins, M

    2015-11-01

    The setup and first results from commissioning of a fast online photon energy spectrometer for the vacuum ultraviolet free electron laser at Hamburg (FLASH) at DESY are presented. With the use of the latest advances in detector development, the presented spectrometer reaches readout frequencies up to 1 MHz. In this paper, we demonstrate the ability to record online photon energy spectra on a shot-to-shot base in the multi-bunch mode of FLASH. Clearly resolved shifts in the mean wavelength over the pulse train as well as shot-to-shot wavelength fluctuations arising from the statistical nature of the photon generating self-amplified spontaneous emission process have been observed. In addition to an online tool for beam calibration and photon diagnostics, the spectrometer enables the determination and selection of spectral data taken with a transparent experiment up front over the photon energy of every shot. This leads to higher spectral resolutions without the loss of efficiency or photon flux by using single-bunch mode or monochromators.

  13. Quasimonoenergetic and low emittance ion bunch generation from ultrathin targets by counterpropagating laser pulses of ultrarelativistic intensities

    CERN Document Server

    Avetissian, H K; Mkrtchian, G F; Sedrakian, Kh V

    2011-01-01

    A new method for generation of quasimonoenergetic and low emittance fast ion/nuclei bunches of solid densities from nanotargets by two counterpropagating laser pulses of ultrarelativistic intensities is proposed, based on the threshold phenomenon of particles "reflection" due to induced nonlinear Compton scattering. Particularly, a setup is considered which provides generation of ion bunches with parameters that are required in hadron therapy.

  14. Simulation of bunches coalesing in the main ring, in the presence of a high-frequency, wide-band resonator

    Energy Technology Data Exchange (ETDEWEB)

    Garoby, R.

    1986-12-04

    During the first part of the coalescing process, bunches are being stretched until they fill the approx. =1 kV at 53 MHz bucket. Applying the ''Keil-Schnell-Boussard'' criteria for microwave instability inside that bunch gives: vertical bar Z/n vertical bar less than or equal to 5.6 ..cap omega.. for N/sub b/ = 10/sup 10/ ppB. It is very likely that local instabilities develop inside the bunch during the manipulation. The computer program ESME was run under these conditions to give an approximate picture of the bunch distortions. Outputs are presented here. Since microwave signals had been observed during the second part of coalescing (bunch rotation), some simulations have been done at that part. No catastrophic degradation showed up with the model used, as the computer outputs indicate. 35 figs.

  15. Design And Verification of Controllers for Coupled Bunch Instabilities Using Optimal Control Theory And Numerical Simulation: Predictions for PEP II

    Energy Technology Data Exchange (ETDEWEB)

    Hindi, Haitham; Prabhakar, Shyam; Fox, John D.; Linscott, Ivan; Teytelman, Dmitri; /SLAC

    2011-08-31

    We present a technique for the design and verification of efficient bunch-by-bunch controllers for damping longitudinal multibunch instabilities. The controllers attempt to optimize the use of available feedback amplifier power - one of the most expensive components of a feedback system - and define the limits of the closed loop system performance. Our design technique alternates between analytic computation of single bunch optimal controllers and verification on a multibunch numerical simulator. The simulator uses PEP-II parameters and identifies unstable coupled bunch modes, their growth rates and their damping rates with feedback. The results from the simulator are shown to be in reasonable agreement with analytical calculations based on the single bunch model. The technique is then used to evaluate the performance of a variety of controllers proposed for PEP-II.

  16. Towards swift ion bunch acceleration by high-power laser pulses at the Centre for Advanced Laser Applications (CALA)

    Science.gov (United States)

    Lindner, F. H.; Haffa, D.; Bin, J. H.; Englbrecht, F.; Gao, Y.; Gebhard, J.; Hartmann, J.; Hilz, P.; Kreuzer, C.; Lehrack, S.; Ostermayr, T. M.; Rösch, T. F.; Speicher, M.; Würl, M.; Parodi, K.; Schreiber, J.; Thirolf, P. G.

    2017-07-01

    Laser-driven acceleration of ions has inspired novel applications, that can benefit from ion bunch properties different from conventionally (non-laser based) accelerated particle beams. Those differences range from extremely short bunch durations, broad energy spectra, large divergence angles and small source sizes to ultra-high ion bunch densities. So far, the main focus of research has been concentrating on the physics of the interaction of intense laser pulses with plasmas and the related mechanisms of ion acceleration. Now, the new Centre for Advanced Laser Applications (CALA) near Munich aims at pushing these ion bunches towards applications, including radiation therapy of tumors and the development of heavy ion bunches with solid-state-like density. These are needed for novel reaction mechanisms ('fission-fusion') to study the origin of heavy elements in the universe and to prepare for related studies at the upcoming EU-funded high-power laser facility ELI - Nuclear Physics in Bucharest.

  17. Spatial and temporal beam profiles for the LHC using synchrotron light

    Science.gov (United States)

    Jeff, A.; Bart Pedersen, S.; Boccardi, A.; Bravin, E.; Fisher, A. S.; Guerrero Ollacarizqueta, A.; Lefevre, T.; Rabiller, A.; Welsch, C. P.

    2010-04-01

    Synchrotron radiation is emitted whenever a beam of charged particles passes though a magnetic field. The power emitted is strongly dependent on the relativistic Lorentz factor of the particles, which itself is proportional to the beam energy and inversely proportional to the particle rest mass. Thus, synchrotron radiation is usually associated with electron accelerators, which are commonly used as light sources. However the largest proton machines reach sufficiently high energies to make synchrotron light useful for diagnostic purposes. The Large Hadron Collider at CERN will accelerate protons up to an energy of 7TeV. An optical arrangement has been made which focuses synchrotron light from two LHC magnets to image the cross-section of the beam. It is also planned to use this setup to produce a longitudinal profile of the beam by use of fast Single Photon Counting. This is complicated by the bunched nature of the beam which needs to be measured with a very large dynamic range. In this contribution we present early experimental data of the transverse LHC beam profile together with a scheme for measuring the longitudinal profile with a time resolution of 50 ps. It includes the use of a gating regime to increase the dynamic range of the photon counter and a three-stage correction algorithm to compensate for the detector's deadtime, afterpulsing and pile-up effects.

  18. Experimental Cooling of Bunched Beams in FNAL’s Accumulator Ring

    Energy Technology Data Exchange (ETDEWEB)

    Claus, J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1990-02-01

    This report describes some experiments on stochastic cooling of bunched beams which were performed in FNAL's Accumulator ring in the beginning of September 1989. I precede that description with a rough overview of that ring in order to make the interpretation of the experimental results easier.

  19. Preliminary design of a bunching system for the CLIC polarized electron source

    CERN Document Server

    Zhou, F; Sheppard, J

    2009-01-01

    Major parameters of the CLIC and ILC electron sources are given in Table I. It is shown that the CLIC source needs to provide 312 15-ps-long 2-GHz microbunches. There are two approaches to achieve the time structure [2]: one is to develop a 2-GHz optical pulse train, and the other to develop a 156-ns-long CW optical pulse and use an RF bunching system to generate 312 2-GHz microbunches. The former scheme may ease the RF bunching system but still need it to bunch 100-ps of microbunch down to 15-ps level. Otherwise, a huge amount of energy spread is accumulated when the beam is accelerated through downstream 2-GHz accelerator. In addition, in the former scheme, the space charge is high and surface charge is not yet proven in the parameter regime and 2-GHz mode locked laser is challenging. The latter scheme needs a high-efficiency bunching system to generate 312 15-ps microbunches with 2-GHz repetition rate but it has some notable advantages: a 156-ns CW laser technique is matured, and the charge limit behavior ...

  20. Polarized e-bunch acceleration at Cornell RCS: Tentative tracking simulations

    Energy Technology Data Exchange (ETDEWEB)

    Meot, F. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ptitsyn, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ranjbar, V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rubin, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-10-19

    An option as an injector into eRHIC electron storage ring is a rapid-cyclic synchrotron (RCS). Rapid acceleration of polarized electron bunches has never been done, Cornell synchrotron might lend itself to dedicated tests, which is to be first explored based on numerical investigations. This paper is a very preliminary introduction to the topic.

  1. Stability Criteria for High-Intensity Single-Bunch Beams in Synchrotrons

    CERN Document Server

    Métral, Elias

    2002-01-01

    In circular accelerators, the interaction between the beam and its surroundings is described in terms of bunched-beam modes through Sacherer's formalism. As the bunch intensity increases, the different modes, separated by the synchrotron frequency, can no longer be treated separately. In this regime, the wake fields couple the modes together and a wave pattern travelling along the bunch is created. It leads to the longitudinal and transverse mode-coupling instabilities, aspects of which are discussed under many different names in a variety of different papers. The present work reviews and unifies these approaches. It is shown that for the transverse plane, the same intensity threshold is obtained through 5 seemingly diverse formalisms: (i) transverse mode coupling, (ii) beam break-up, (iii) fast blow-up, (iv) post head-tail, and (v) a quasi coasting-beam approach using the peak values of bunch current and momentum spread as input for the coasting-beam formula. For the longitudinal plane, a new stability crite...

  2. Studies of Longitudinal Coupled-Bunch Instabilities in the LHC Injectors Chain

    CERN Document Server

    AUTHOR|(CDS)2087149; Migliorati, M

    Among several challenging objectives of the LHC Injectors Upgrade project, one aim is to double the beam intensity of the CERN Proton Synchrotron (PS) in order to achieve the integrated luminosity target of the High-Luminosity LHC project. A known limitation to reach the required high intensity is caused by the longitudinal coupled-bunch (CB) oscillations developing above the PS transition energy. The unwanted oscillations induce large bunch-to-bunch intensity variations not compatible with the specifications of the future LHC-type beams. In 2014 a new longitudinal kicker cavity has been installed, the Finemet cavity, as a part of the new digital coupled-bunch feedback (FB) system. The Finemet cavity allows with its large frequency bandwidth, to damp all the expected oscillation modes simultaneously. In the framework of this PhD study the impedance contribution of this equipment has been analyzed starting from the present knowledge of the machine impedance. A model of both the 10 MHz and the Finemet has been ...

  3. Utilization of Liquid Smoke from Oil Palm Empty Fruit Bunches on Raw Rubber Processing

    Directory of Open Access Journals (Sweden)

    Hidayati Hidayati

    2011-06-01

    Full Text Available Research utilization of liquid smoke from oil palm empty fruit bunches of raw rubber has been made to utilize solid waste from industrial processing of oil palm empty fruit bunches of oil palm so that it becomes economically valuable products. This research has been done by pyrolysis of oil palm empty fruit bunches at a temperature of 400oC for 5, 6, 7 and 8 hours. The results show that the pyrolysis liquid smoke oil palm empty fruit bunches for 8 hours give a high concentration of phenol and acetic acid, respectively 5% and 0.454%. Liquid smoke that has been obtained is used as a coagulant in raw rubber plantation crops of the people residing in the village of Ambawang, Kubu Raya District, West Kalimantan. Results of treatment of liquid smoke on raw rubber  show that the rubber products that have been frozen and dried are superior in terms of color, smell and drying time compared with the treatment of formic acid and water battery which has been added so far on raw rubber by the local rubber farmers.

  4. Oil palm empty-fruit bunch application effects on the earthworm ...

    African Journals Online (AJOL)

    The amounts of polyphenols at several stages of oil palm empty-fruit bunch (EFB) composting, the types of phenol compounds in several types of EFB composting processes and the effects of phenol compounds on EFB composting in an earthworm population were evaluated under field conditions. The amount of ...

  5. Bioconversion of empty fruit bunches (EFB) and palm oil mill effluent ...

    African Journals Online (AJOL)

    This study shows the performance of Trichoderma virens as an activator for conversion of empty fruit bunches (EFB) and palm oil mill effluent (POME) into compost. EFB and POME are two abundant wastes produced by oil palm industries which keep accumulating. Since there is no proper way to dispose these wastes, ...

  6. Delignification outperforms alkaline extraction for xylan fingerprinting of oil palm empty fruit bunch

    NARCIS (Netherlands)

    Murciano Martínez, Patricia; Kabel, Mirjam A.; Gruppen, Harry

    2016-01-01

    Enzyme hydrolysed (hemi-)celluloses from oil palm empty fruit bunches (EFBs) are a source for production of bio-fuels or chemicals. In this study, after either peracetic acid delignification or alkaline extraction, EFB hemicellulose structures were described, aided by xylanase hydrolysis.

  7. Dilute Ionic Liquids Pretreatment of Palm Empty Bunch and Its Impact to Produce Bioethanol

    Directory of Open Access Journals (Sweden)

    Lucy Arianie

    2014-06-01

    Full Text Available Ethanol production through ionic liquids pretreatment of palm empty bunch (PEB was carried out. This research aims to investigate impact of ionic liquids synthetic i.e 1-butyl- 3-methyl imidazoliumbromide or [BMIM]bromide toward cellulose’s palm empty bunch and convert its cellulose into bioethanol. Ionic liquid was synthesized through reflux and microwave assisted synthesis methods. Research investigation showed that microwave assisted synthesis produce [BMIM]bromide 90% faster than reflux method. The characterization of synthesized product using FTIR, 1H-NMR, 13C-NMR and LC-MS showed that these reactions have been carried out successfully. Scanning electron microscope figure out changes morphological surface of palm empty bunch caused by ionic liquid pretreatment. Crystallinity index of PEB milled and cellulose of PEFB after [BMIM]bromide dissolution were identified using comparison of PEB FTIR spectrum. Cellulose without dilute [BMIM]bromide have higher LOI number than cellulose after [BMIM]bromide dissolution. It indicated that a large part of cellulose after dissolution has been changed into amorf. Hydrolysis residue of palm empty bunch hydrolyzed by sulfuric acids 5%, 100 0C for 5 hours and produce 685 ppm of reducing sugar. Simultaneous Saccharification and Fermentation using Trichoderma viride and Saccharomyce cerevisiae for 5 days produce 0,69% of bioethanol.

  8. Dilute Ionic Liquids Pretreatment of Palm Empty Bunch and Its Impact to Produce Bioethanol

    Directory of Open Access Journals (Sweden)

    Lucy Arianie

    2013-12-01

    Full Text Available Ethanol production through ionic liquids pretreatment of palm empty bunch (PEB was carried out. This research aims to investigate impact of ionic liquids synthetic i.e 1-butyl-3-methyl imidazoliumbromide or [BMIM]bromide toward cellulose’s palm empty bunch and convert its cellulose into bioethanol. Ionic liquid was synthesized  through reflux and microwave assisted synthesis methods. Research investigation showed that microwave assisted synthesis produce [BMIM]bromide 90% faster than reflux method. The characterization of synthesized product using FTIR, 1H-NMR, 13C-NMR and LC-MS showed that these reactions have been carried out successfully. Scanning electron microscope figure out changes morphological surface of palm empty bunch caused by ionic liquid pretreatment. Crystallinity index of PEB milled and cellulose of PEFB after [BMIM]bromide dissolution were identified using comparison of PEB FTIR spectrum. Cellulose without dilute [BMIM]bromide have higher LOI number than cellulose after [BMIM]bromide dissolution. It indicated that a large part of cellulose after dissolution has been changed into amorf. Hydrolysis residue of palm empty bunch hydrolyzed by sulfuric acids 5%, 100 0C for 5 hours and produce 685 ppm of reducing sugar. Simultaneous Saccharification and Fermentation using Trichoderma viride and Saccharomyce cerevisiae  for 5 days produce 0,69% of bioethanol.

  9. Effects of oil palm bunch refuse on humic acid content of five soils ...

    African Journals Online (AJOL)

    The effect of the addition of composted oil palm bunch refuse on five different soils supporting palms with respect to the acidic functional groups of the humic acids in the soils was investigated. The composts was added to the soils at different rates. The results showed that there was a highly significant (P =0.001) increase in ...

  10. Potential of oil palm empty fruit bunch ash for remediation of crude ...

    African Journals Online (AJOL)

    The potential of oil palm empty fruit bunch ash for remediation of crude oil polluted soil was investigated. Three levels (100 g, 200 g and 300 g) of ash treatments in 2 kg of soil were set up alongside a control (nil ash) after pollution with100 ml of crude oil. Composite soil samples were collected and analyzed at intervals of ...

  11. Study of the bunch crossing identification at LHC using microstrip gas chambers

    Energy Technology Data Exchange (ETDEWEB)

    Angelini, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Bacchetta, N. [Istituto Nazionale di Fisica Nucleare, Padua (Italy); Bellazzini, R. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Bon, D. [IPN, Lyon (France); Bondar, A. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Bozzo, M. [Istituto Nazionale di Fisica Nucleare, Genoa (Italy); Brez, A. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Brom, J.M. [Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Caldero, J.C. [IPN, Lyon (France); Clergeau, J.F. [IPN, Lyon (France); Contardo, D. [IPN, Lyon (France); French, M. [Rutherford Appleton Lab., Chilton (United Kingdom); Giraldo, A. [Istituto Nazionale di Fisica Nucleare, Padua (Italy); Guillot, G. [IPN, Lyon (France); Hall, G. [IC, London (United Kingdom); Hammarstroem, R. [European Organization for Nuclear Research, Geneva (Switzerland); Haroutunian, R. [IPN, Lyon (France); Jones, L. [Rutherford Appleton Lab., Chilton (United Kingdom); Kachelhoffer, T. [Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Kryn, D. [IPN, Lyon (France); Loreti, M. [Istituto Nazionale di Fisica Nucleare, Padua (Italy); Ladzinski, T. [European Organization for Nuclear Research, Geneva (Switzerland); Mabo, J.C. [IPN, Lyon (France); MacEvoy, B. [IC, London (United Kingdom); Massai, M. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Miguet, M. [IPN, Lyon (France); Millmore, M. [IC, London (United Kingdom); Morelli, A. [Istituto Nazionale di Fisica Nucleare, Genoa (Italy); Nagaslaev, V. [European Organization for Nuclear Research, Geneva (Switzerland); Pallares, A. [Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Parodi, F. [Istituto Nazionale di Fisica Nucleare, Genoa (Italy); Peisert, A. [European Organization for Nuclear Research, Geneva (Switzerland); Quian, S. [Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires

    1996-01-01

    During the beam test of a tracker prototype for the Compact Muon Solenoid detector proposed for the LHC, the time response of the Microstrip Gas Chambers was studied using different gases and chamber gaps. The subsequent efficiency to identify the bunch crossings at LHC is discussed for several algorithms used in the off-line signal processing of the data. (orig.).

  12. Use of palm bunch ash-based mineral water in a geriatric patient ...

    African Journals Online (AJOL)

    Optimal water, electrolyte and acid-base balance are of great importance in the management of human disease generally. Palm bunch ash (PBA) is obtained by complete combustion of the husk of Elaeis guineensis (oil palm tree). PBA-based mineral water is innocuous, safe and cost-effective for the treatment of systemic ...

  13. Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges.

    Science.gov (United States)

    Plenis, Alina; Oledzka, Ilona; Kowalski, Piotr; Baczek, Tomasz

    2016-01-01

    During the last few years there has been a growing interest in research focused on the metabolism of steroid hormones despite that the study of metabolic hormone pathways is still a difficult and demanding task because of low steroid concentrations and a complexity of the analysed matrices. Thus, there has been an increasing interest in the development of new, more selective and sensitive methods for monitoring these compounds in biological samples. A lot of bibliographic databases for world research literature were structurally searched using selected review question and inclusion/exclusion criteria. Next, the reports of the highest quality were selected using standard tools (181) and they were described to evaluate the advantages and limitations of different approaches in the measurements of the steroids and their metabolites. The overview of the analytical challenges, development of methods used in the assessment of the metabolic pathways of steroid hormones, and the priorities for future research with a special consideration for liquid chromatography (LC) and capillary electrophoresis (CE) techniques have been presented. Moreover, many LC and CE applications in pharmacological and psychological studies as well as endocrinology and sports medicine, taking into account the recent progress in the area of the metabolic profiling of steroids, have been critically discussed. The latest reports show that LC systems coupled with mass spectrometry have the predominant position in the research of steroid profiles. Moreover, CE techniques are going to gain a prominent position in the diagnosis of hormone levels in the near future.

  14. Deposition Profile Analysis from DIII-D Metal Rings Campaign Outer-Midplane Collector Probe Diagnostic and Utilization of Enriched Isotopic Tungsten Tracer Particles

    Science.gov (United States)

    Donovan, D. C.; Duran, J.; Zamperini, S.; Lee, S.; Unterberg, E. A.; Wampler, W. R.; Rudakov, D. L.; Elder, D.; Stangeby, P. C.; Abrams, T.

    2017-10-01

    The DIII-D Metal Rings Campaign used isotopically-enriched, W-coated divertor tiles coupled with dual-facing midplane collector probes (CPs) in the far Scrape-off Layer (SOL). Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) results are presented characterizing the isotopic ratios of deposited W on the CPs and which give quantitative information on the transport of W from specific poloidal locations within the lower outer divertor region having different isotopically-marked tiles. Rutherford Backscattering Spectrometry (RBS) of these CPs has provided areal densities of elemental W content. These resultant W deposition profiles were compared with DIVIMP modelling of the far-SOL to better understand impurity transport in the edge plasma. CPs were exposed for 37 distinct operating configurations (L-mode/H-mode, forward/reverse Bt, strikepoint position). Radial decay lengths (RDL) between 5 and 50 mm were observed with consistently narrower RDL and higher peak W content on the side of the probes connected along field lines to the inner divertor, indicating a concentration of W in the upstream plasma. Correlations are discussed between peak W content, RDL, and isotopic profiles on the CPs over a wide range of conditions. Work supported by US DOE under DE-AC05-00OR22725, DE-FG02-07ER54917, DE-FC02-04ER54698, DE-NA0003525.

  15. [Diagnostic means for tuberculosis].

    Science.gov (United States)

    Jabri, H; Lakhdar, N; El Khattabi, W; Afif, H

    2016-10-01

    Tuberculosis is a public health problem. In recent years, there is a change in the epidemiological profile of tuberculosis. The diagnosis of tuberculosis is based on clinical and radiological arguments but confirmation is bacteriological and/or histological. Culture remains the gold standard. Technological progress especially in molecular biology provides the clinician now new means of tuberculosis diagnostics. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  16. Usefulness of japanese bunching onion (Allium fistulosum L. for forcing in greenhouse

    Directory of Open Access Journals (Sweden)

    Maria Tendaj

    2012-12-01

    Full Text Available The purpose of this work was the evaluation of yielding and the content of some chemical ingredients of Japanese bunching onion yield obtained from forcing in greenhouse conditions. Plants used for forcing were from field cultivation and had the pseudostem trimmed in the autumn of each year (2002, 2003 and 2004 at the height of 2-4 and 8-10 cm. In the spring of the following year (2003, 2004 and 2005 from the middle of March, the plants were forced in a heated greenhouse (temperature 16-20°C and an unheated one (temperature 6-12 °C. The whole yield was evaluated when the plants reached the market size for bunching. The weight and height were determined in the plants, as well as the number of laterals and leaves in clusters. In green shoots and the pseudostem, the content of dry weight, total and reducing sugars, L-ascorbic acid, flavonoids and phenolic acids were determined. Very high yield of plants useful for bunching was obtained (average 13.7 kg·m-2 of area. The plants with a longer pseudostem before forcing yielded better. The conditions of forcing did not have a significant influence on the size of the obtained yield, but the content of L-ascorbic acid and flavonoids was much higher (especially in green shoots in the plants from forcing in the unheated greenhouse. Lower temperature at the time of forcing was favorable to higher reducing sugar content, especially in the pseudostem. Japanese bunching onion turned out to be useful for forcing for harvest in bunching form.

  17. Artemisia umbelliformis Lam. and Génépi Liqueur: Volatile Profile as Diagnostic Marker for Geographic Origin and To Predict Liqueur Safety.

    Science.gov (United States)

    Boggia, Lorenzo; Pignata, Giuseppe; Sgorbini, Barbara; Colombo, Maria Laura; Marengo, Arianna; Casale, Manuela; Nicola, Silvana; Bicchi, Carlo; Rubiolo, Patrizia

    2017-04-05

    Artemisia umbelliformis, commonly known as "white génépi", is characterized by a volatile fraction rich in α- and β-thujones, two monoterpenoids; under European Union (EU) regulations these are limited to 35 mg/L in Artemisia-based beverages because of their recognized activity on the human central nervous system. This study reports the results of an investigation to define the geographical origin and thujone content of individual plants of A. umbelliformis from different geographical sites, cultivated experimentally at a single site, and to predict the thujone content in the resulting liqueurs through their volatile fraction. Headspace solid phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS) and non-separative HS-SPME-MS were used as analytical platforms to create a database suitable for chemometric description and prediction through linear discriminant analysis (LDA). HS-SPME-MS was applied to shorten analysis time. With both approaches, a diagnostic prediction of (i) plant geographical origin and (ii) thujone content of plant-related liqueurs could be made.

  18. The Possible Diagnostic and Prognostic Use of Systemic Chemokine Profiles in Clinical Medicine—The Experience in Acute Myeloid Leukemia from Disease Development and Diagnosis via Conventional Chemotherapy to Allogeneic Stem Cell Transplantation

    Directory of Open Access Journals (Sweden)

    Øystein Bruserud

    2013-02-01

    Full Text Available Chemokines are important regulators of many different biological processes, including (i inflammation with activation and local recruitment of immunocompetent cells; (ii angiogenesis as a part of inflammation or carcinogenesis; and (iii as a bridge between the coagulation system and inflammation/immune activation. The systemic levels of various chemokines may therefore reflect local disease processes, and such variations may thereby be used in the routine clinical handling of patients. The experience from patients with myeloproliferative diseases, and especially patients with acute myeloid leukemia (AML, suggests that systemic plasma/serum cytokine profiles can be useful, both as a diagnostic tool and for prognostication of patients. However, cytokines/chemokines are released by a wide range of cells and are involved in a wide range of biological processes; the altered levels may therefore mainly reflect the strength and nature of the biological processes, and the optimal clinical use of chemokine/cytokine analyses may therefore require combination with organ-specific biomarkers. Chemokine levels are also altered by clinical procedures, therapeutic interventions and the general status of the patients. A careful standardization of sample collection is therefore important, and the interpretation of the observations will require that the overall clinical context is considered. Despite these limitations, we conclude that analysis of systemic chemokine/cytokine profiles can reflect important clinical characteristics and, therefore, is an important scientific tool that can be used as a part of future clinical studies to identify clinically relevant biomarkers.

  19. Higher Order Modes for Beam Diagnostics in Third Harmonic 3.9 GHz Accelerating Modules

    CERN Document Server

    Baboi, N; Flisgen, T; Glock, H-W; Jones, R M; Shinton, I R R; Zhang, P

    2011-01-01

    An international team is currently investigating the best way to use Higher Order Modes (HOM) for beam diagnostics in 3.9 GHz cavities. HOMs are excited by charged particles when passing through an accelerating structure. Third harmonic cavities working at 3.9 GHz have been installed in FLASH to linearize the bunch energy profile. A proof-of-principle of using HOMs for beam monitoring has been made at FLASH in the TESLA 1.3 GHz cavities. Since the wakefields generated in the 3.9 GHz cavities are significantly larger, their impact on the beam should be carefully minimized. Therefore our target is to monitor HOMs and minimize them by aligning the beam on the cavity axis. The difficulty is that, in comparison to the 1.3 GHz cavities, the HOM-spectrum is dense, making it difficult to identify individual modes. Also, most modes propagate through the whole cryomodule containing several cavities, making it difficult to measure local beam properties. In this paper the options for the HOM-based beam position monitors ...

  20. Effect of source/sink ratios on yield components, growth dynamics and structural characteristics of oil palm (Elaeis guineensis) bunches.

    Science.gov (United States)

    Pallas, Benoît; Mialet-Serra, Isabelle; Rouan, Lauriane; Clément-Vidal, Anne; Caliman, Jean-Pierre; Dingkuhn, Michael

    2013-04-01

    Source/sink ratios are known to be one of the main determinants of oil palm growth and development. A long-term experiment (9 years) was conducted in Indonesia on mature oil palms subjected to continuous bunch ablation and partial defoliation treatments to artificially modify source/sink ratios. During the experiment, all harvested bunches were dissected and phenological measurements were carried out to analyse the effect of source/sink ratios on yield components explaining variations in bunch number, the number of fruits per bunch and oil dry weight per fruit. An integrative variable (supply/demand ratio) describing the ratio between the assimilate supply from sources and the growing organ demand for carbohydrate was computed for each plant on a daily basis from observations of the number of developing organs and their sink strength, and of climate variables. Defoliation and bunch ablation affected the bunch number and the fruit number per bunch. Variations in bunch number per month were mainly due to variations in the fraction of aborted inflorescence and in the ratio between female and male inflorescences. Under fluctuating trophic conditions, variations in fruit number per bunch resulted both from changes in fruit-set and in the number of branches (rachillae) per inflorescence. For defoliated plants, the decrease in the number of developing reproductive sinks appeared to be sufficient to maintain fruit weight and oil concentration at the control level, without any major decrease in the concentration of non-structural carbohydrate reserves. Computation of the supply/demand ratio revealed that each yield component had a specific phase of sensitivity to supply/demand ratios during inflorescence development. Establishing quantitative relationships between supply/demand ratios, competition and yield components is the first step towards a functional model for oil palm.

  1. Characterization and pathogenicity of Alternaria spp. strains associated with grape bunch rot during post-harvest withering.

    Science.gov (United States)

    Lorenzini, Marilinda; Zapparoli, Giacomo

    2014-09-01

    Alternaria is a fungal agent of grape bunch rot which occurs during withering, a process which produces passito style wines. Seven isolates of Alternaria spp. were characterized using morphological examination, genotypic analysis and pathogenicity. Six of these isolates produced conidiophores and conidia displaying sporulation patterns typical of the Alternaria alternata species-group. Variability in colony morphology and growth on different media was observed. Phylogenetic analysis of internal transcribed spacer (ITS) sequences clustered all isolates within a monophyletic clade, while intergenic spacer region (IGS)-RFLP profiles were congruent with those of A. alternata and Alternaria arborescens. RAPD-PCR proved helpful in discriminating between strains. To assay strain pathogenicity, grape berries were infected while undergoing withering conditions at different temperatures. Disease capacity was found to be strain dependent and varied consistently between the most and least aggressive strains. This study has provided interesting information on polymorphism within Alternaria spp. populations in withered grapes and on understanding the saprophytic role of this fungus during the post-harvest dehydrating process. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. In vitro and in silico characterization of metagenomic soil-derived cellulases capable of hydrolyzing oil palm empty fruit bunch

    Directory of Open Access Journals (Sweden)

    Laura Marcela Palma Medina

    2017-09-01

    Full Text Available Diversification of raw material for biofuel production is of interest to both academia and industry. One attractive substrate is a renewable lignocellulosic material such as oil palm (Elaeis guineensis Jacq. empty fruit bunch (OPEFB, which is a byproduct of the palm oil industry. This study aimed to characterize cellulases active against this substrate. Cellulases with activity against OPEFB were identified from a metagenomic library obtained from DNA extracted from a high-Andean forest ecosystem. Our findings show that the highest cellulolytic activities were obtained at pH and temperature ranges of 4–10 and 30 °C–60 °C, respectively. Due to the heterogeneous character of the system, degradation profiles were fitted to a fractal-like kinetic model, evidencing transport mass transfer limitations. The sequence analysis of the metagenomic library inserts revealed three glycosyl hydrolase families. Finally, molecular docking simulations of the cellulases were carried out corroborating possible exoglucanase and β-glucosidase activity.

  3. Facile production of nanostructured cellulose from Elaeis guineensis empty fruit bunch via one pot oxidative-hydrolysis isolation approach.

    Science.gov (United States)

    Chen, You Wei; Lee, Hwei Voon; Abd Hamid, Sharifah Bee

    2017-02-10

    Cellulose in nanostructures was successfully isolated from empty fruit bunch biomass via a novel one-pot oxidative-hydrolysis technique. The physicochemical properties of nanocellulose prepared via one-pot process have shown comparable characteristics as products isolated via conventional multistep purification approach (namely dewaxing, chlorite bleaching process, alkalization, and acid hydrolysis). The chemical composition study indicated that the one-pot oxidative-hydrolysis process successfully extracted cellulose (91.0%), with the remaining minority being hemicellulose and lignin (∼6%) in the final product. Crystallinity profile of one-pot treated product (80.3%) was higher than that of multistep isolated nanocellulose (75.4%), which indicated that the disorder region (amorphous) in cellulose fibers was successfully removed. In additional to that, the morphology study demonstrated that nanocellulose prepared by one-pot process rendered spider-web-like network nanostructure, with an average diameter of fibers at a range of 51.6±15.4nm. The nanocellulose product showed high thermal stability (320°C), which was ready for nanocomposite application. One-pot oxidative-hydrolysis technique is a simple and versatile route for the preparation of nanocellulose from complex biomass within 90°C and 6h period, with minimum wastewater as compared to the multistep process. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Direct Numerical Modeling of E-Cloud Driven Instability of a Bunch Train in the CERN SPS

    CERN Document Server

    Vay, J-L; Furman, M A

    2011-01-01

    The simulation package WARP-POSINST was recently upgraded for handling multiple bunches and modeling concurrently the electron cloud buildup and its effect on the beam, allowing for direct self-consistent simulation of bunch trains generating, and interacting with, electron clouds. We have used the WARP-POSINST package on massively parallel supercomputers to study the buildup and interaction of electron clouds with a proton bunch train in the CERN SPS accelerator. Results suggest that a positive feedback mechanism exists between the electron buildup and the e-cloud driven transverse instability, leading to a net increase in predicted electron density.

  5. 4-Hydroxybenzoic acid from hydrothermal pretreatment of oil palm empty fruit bunches - Its origin and influence on biomass conversion

    DEFF Research Database (Denmark)

    Rasmussen, Helena; Mogensen, Kit H.; Jeppesen, Martin D.

    2016-01-01

    An unknown major compound, characteristically occurring during processing of oil palm empty fruit bunches was identified with LC-DAD-ESI-MS/MS to be 4-hydroxybenzoic acid. Lignin from oil palm empty fruit bunches contains 4-hydroxybenzoic acid so a tempting conclusion was that the 4-hydroxybenzoic...... or fucose, e.g. pectin rich biomasses. Assessment of the influence of 4-hydroxybenzoic acid in the enzymatic hydrolysis of pretreated oil palm empty fruit bunches as well as its presence during fermentation showed that 4-hydroxybenzoic acid is not inhibiting or mediating neither on the enzymatic hydrolysis...

  6. On the scaling law of single bunch transverse instability threshold current vs. the chromaticity in electron storage rings

    CERN Document Server

    Gao, J

    2002-01-01

    Based on the single bunch transverse instability theory established by Gao (Nucl. Instr. and Meth. A 416 (1998) 186), it is shown that the functional relation between the instability threshold bunch current and the chromaticity of the machine is I sub t sub h propor to xi sub c sup d , with d approx 1.3 and d approx 2.3 at potential well and microwave instability dominated bunch lengthening regimes, respectively. These scaling laws are confirmed by the experimental results from ESRF.

  7. Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays

    Directory of Open Access Journals (Sweden)

    Francesca Capone

    2016-01-01

    Full Text Available In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors able to repair the tissue and to promote cancer cell survival, implantation, and growth. In this contest, the cytokines contribute to the development of these processes becoming active before and during the inflammatory process and playing an important function at the various disease levels. Thus, these proteins can represent specific markers of tumor development and progression. Therefore the “cytokinome” term is used to indicate the evaluation of cytokine pattern by using an “omics” approach. Newly, specific protein chips of considerable and improved sensitivity are being developed to determine simultaneously several and different cytokines. This can be achieved by a multiplex technology that, through the use of small amounts of serum or other fluids, is used to determine the presence and the levels of underrepresented cytokines. Since this method is an accurate, sensitive, and reproducible cytokine assay, it is already used in many different studies. Thus, this review focuses on the more latest aspects related to cytokinome profile evaluation in different cancers.

  8. Serum Cytokinome Profile Evaluation: A Tool to Define New Diagnostic and Prognostic Markers of Cancer Using Multiplexed Bead-Based Immunoassays.

    Science.gov (United States)

    Capone, Francesca; Guerriero, Eliana; Sorice, Angela; Colonna, Giovanni; Ciliberto, Gennaro; Costantini, Susan

    2016-01-01

    In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors able to repair the tissue and to promote cancer cell survival, implantation, and growth. In this contest, the cytokines contribute to the development of these processes becoming active before and during the inflammatory process and playing an important function at the various disease levels. Thus, these proteins can represent specific markers of tumor development and progression. Therefore the "cytokinome" term is used to indicate the evaluation of cytokine pattern by using an "omics" approach. Newly, specific protein chips of considerable and improved sensitivity are being developed to determine simultaneously several and different cytokines. This can be achieved by a multiplex technology that, through the use of small amounts of serum or other fluids, is used to determine the presence and the levels of underrepresented cytokines. Since this method is an accurate, sensitive, and reproducible cytokine assay, it is already used in many different studies. Thus, this review focuses on the more latest aspects related to cytokinome profile evaluation in different cancers.

  9. The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.

    Science.gov (United States)

    Wichmann, Gunnar; Rosolowski, Maciej; Krohn, Knut; Kreuz, Markus; Boehm, Andreas; Reiche, Anett; Scharrer, Ulrike; Halama, Dirk; Bertolini, Julia; Bauer, Ulrike; Holzinger, Dana; Pawlita, Michael; Hess, Jochen; Engel, Christoph; Hasenclever, Dirk; Scholz, Markus; Ahnert, Peter; Kirsten, Holger; Hemprich, Alexander; Wittekind, Christian; Herbarth, Olf; Horn, Friedemann; Dietz, Andreas; Loeffler, Markus

    2015-12-15

    Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may facilitate patient treatment decision. We characterize head and neck squamous cell carcinomas (HNSCC) with different HPV16 DNA and RNA (E6*I) status from 290 consecutively recruited patients by gene expression profiling and targeted sequencing of 50 genes. We show that tumors with transcriptionally inactive HPV16 (DNA+ RNA-) are similar to HPV-negative (DNA-) tumors regarding gene expression and frequency of TP53 mutations (47%, 8/17 and 43%, 72/167, respectively). We also find that an immune response-related gene expression cluster is associated with lymph node metastasis, independent of HPV16 status and that disruptive TP53 mutations are associated with lymph node metastasis in HPV16 DNA- tumors. We validate each of these associations in another large data set. Four gene expression clusters which we identify differ moderately but significantly in overall survival. Our findings underscore the importance of measuring the HPV16 RNA (E6*I) and TP53-mutation status for patient stratification and identify associations of an immune response-related gene expression cluster and TP53 mutations with lymph node metastasis in HNSCC. © 2015 UICC.

  10. Study on the Effect of Calcium and Potassium Spray on Date Bunch Fading Disorder

    Directory of Open Access Journals (Sweden)

    Hosein Shekofteh

    2017-02-01

    Full Text Available Introduction: Date bunch fading disorder has been one of the most important problems, which caused economic damage to date plantation area of Iran. It has been first reported on Mozafti cultivar in Kahnuj area, Kerman province. It has often been observed on soft and mid ripening cultivars such as Mozafti, Mordaseng and Kalote. Furthermore, it usually appears on Mozafti cultivar when fruits change from Khalal to Rutab stage. The most important symptoms of this disorder are sudden wilting of fruits and necrotic strips on the upper surface of the main bunch stalk. Incidence and development of these symptoms increase by high temperature, low relative humidity, and hot and dry wind. Several research studies have been carried out on this disorder so far, but the only research about the effect of nutrition on disorder was performed by Rosta (2003. The aim of the present study was to investigate the effect of calcium and potassium spray on date bunch fading and some traits of date fruit in Rigan region, Kerman province. Materials and Methods: The experiment was conducted based on randomized complete block designs with three replicates in Rigan located in east south of Kerman province, Iran, in 2012. Treatments were: T1: control, T2: spray of calcium nitrate at the concentration of 5 ppm, T3: spray of potassium sulfate at the concentration of 5 ppm, and T4: combined spray of calcium nitrate and potassium sulfate at the concentration of 5 ppm. Treatments were applied at Kimri, Hobabok and Khalal stages. Sampling was performed from 3 date palms (3 bunches from each date palm were selected randomly at the second date harvest. Totally, the traits of 200 fruits were measured in each date palm. The traits measured in the present study were: fruit length, fruit diameter, fruit weight, stone weight, stone diameter, and bunch fading percentage. Results and Discussions: According to the data of variance analysis, treatments had a significant effect on wet fruit

  11. Resonant Excitation of Selected Modes by a Train of Electron Bunches in a Rectangular Dielectric Wakefield Accelerator

    CERN Document Server

    Onishchenko, Ivan N; Onishchenko, Nikolay; Sotnikov, Gennadiy

    2005-01-01

    The dielectric wake field accelerator is based on particle acceleration by wake fields excited in a dielectric waveguide by a regular sequence of electron bunches. Enhancement of the accelerating field can be achieved using two phenomena: coherent excitation by many bunches (multibunch effect) and constructive interference of many excited eigenmodes (multimode effect). It was believed that the latter is possible only for planar slab geometry in which the excited modes are equally spaced in frequency. By analysis and simulation, in this presentation the effect of wake field superposition to high amplitude is demonstrated for arbitrary rectangular geometry that is more realizable in experiment. We find this result using simultaneous multibunch and multimode operation providing the repetition frequency of the bunch sequence is equal to the frequency difference between selected modes, whereupon resonant oscillation takes place. Moreover, it is shown that for an appropriate choice of selected modes and bunch repet...

  12. Femtosecond timing-jitter between photo-cathode laser and ultra-short electron bunches by means of hybrid compression

    CERN Document Server

    Pompili, Riccardo; Bellaveglia, M; Biagioni, A; Castorina, G; Chiadroni, E; Cianchi, A; Croia, M; Di Giovenale, D; Ferrario, M; Filippi, F; Gallo, A; Gatti, G; Giorgianni, F; Giribono, A; Li, W; Lupi, S; Mostacci, A; Petrarca, M; Piersanti, L; Di Pirro, G; Romeo, S; Scifo, J; Shpakov, V; Vaccarezza, C; Villa, F

    2017-01-01

    The generation of ultra-short electron bunches with ultra-low timing-jitter relative to the photo-cathode (PC) laser has been experimentally proved for the first time at the SPARC_LAB test-facility (INFN-LNF, Frascati) exploiting a two-stage hybrid compression scheme. The first stage employs RF-based compression (velocity-bunching), which shortens the bunch and imprints an energy chirp on it. The second stage is performed in a non-isochronous dogleg line, where the compression is completed resulting in a final bunch duration below 90 fs (rms). At the same time, the beam arrival timing-jitter with respect to the PC laser has been measured to be lower than 20 fs (rms). The reported results have been validated with numerical simulations.

  13. Excitation of Intra-bunch Vertical Motion in the SPS - Implications for Feedback Control of Ecloud and TMCI Instabilities

    CERN Document Server

    Cesaratto, John; Pivi, M T; Rivetta, C H; Turgut, O; Uemura, S; Hofle, W; Wehrle, U

    2012-01-01

    Electron cloud (ecloud) and transverse mode coupledbunch instabilities (TMCI) limit the bunch intensity in the CERN SPS. This paper presents experimental measurements in the SPS of single-bunch motion driven by a GHz bandwidth vertical excitation system [1]. The nal goal is to quantify the change in internal bunch dynamics as instability thresholds are approached, and quantify the frequencies of internal modes as ecloud effects become signicant. Initially, we have been able to drive the beam and view its motion. We show the excitation of barycentric, head-tail and higher vertical modes at different bunch intensities. The beam motion is analyzed in the time domain, via animated presentations of the sampled vertical signals, and in the frequency domain, via spectrograms showing the modal frequencies vs. time. The demonstration of the excitation of selected internal modes is a signicant step in the development of the feedback control techniques.

  14. Electron-bunch lengthening on higher-harmonic oscillations in storage-ring free-electron lasers.

    Science.gov (United States)

    Sei, Norihiro; Ogawa, Hiroshi; Okuda, Shuichi

    2017-09-01

    The influence of higher-harmonic free-electron laser (FEL) oscillations on an electron beam have been studied by measuring its bunch length at the NIJI-IV storage ring. The bunch length and the lifetime of the electron beam were measured, and were observed to have become longer owing to harmonic lasing, which is in accord with the increase of the FEL gain. It was demonstrated that the saturated FEL power could be described by the theory of bunch heating, even for the harmonic lasing. Cavity-length detuning curves were measured for the harmonic lasing, and it was found that the width of the detuning curve was proportional to a parameter that depended on the bunch length. These experimental results will be useful for developing compact resonator-type FELs by using higher harmonics in the extreme-ultraviolet and the X-ray regions.

  15. The Fast Vertical Single-Bunch Instability after Injection into the CERN Super Proton Synchrotron

    CERN Document Server

    Métral, Elias; Bohl, Thomas; Burkhardt, Helmut; Rumolo, Giovanni; Spataro, Bruno; CERN. Geneva

    2006-01-01

    Since 2003, high-intensity single-bunch proton beams with low longitudinal emittance have been affected by heavy losses after less than one synchrotron period after injection. The effects of the resonance frequency of the responsible impedance, longitudinal emittance and chromaticity on the intensity threshold were already discussed in detail in 2004, comparing analytical predictions with simulation results. In this paper the evolution of the instability between injection and the time of beam loss is our main concern. Measurements are compared with HEADTAIL simulations. A travellingwave pattern propagating along the bunch, which is the signature of a Beam Break-Up or Transverse Mode Coupling Instability (TMCI), is clearly identified. The oscillating frequency, near ~1 GHz, is in good agreement with the usual broad-band impedance model deduced from beam-based measurements like the head-tail growth rate vs. chromaticity.

  16. Electron bunch timing with femtosecond precision in a superconducting free-electron laser.

    Science.gov (United States)

    Löhl, F; Arsov, V; Felber, M; Hacker, K; Jalmuzna, W; Lorbeer, B; Ludwig, F; Matthiesen, K-H; Schlarb, H; Schmidt, B; Schmüser, P; Schulz, S; Szewinski, J; Winter, A; Zemella, J

    2010-04-09

    High-gain free-electron lasers (FELs) are capable of generating femtosecond x-ray pulses with peak brilliances many orders of magnitude higher than at other existing x-ray sources. In order to fully exploit the opportunities offered by these femtosecond light pulses in time-resolved experiments, an unprecedented synchronization accuracy is required. In this Letter, we distributed the pulse train of a mode-locked fiber laser with femtosecond stability to different locations in the linear accelerator of the soft x-ray FEL FLASH. A novel electro-optic detection scheme was applied to measure the electron bunch arrival time with an as yet unrivaled precision of 6 fs (rms). With two beam-based feedback systems we succeeded in stabilizing both the arrival time and the electron bunch compression process within two magnetic chicanes, yielding a significant reduction of the FEL pulse energy jitter.

  17. Matching sub-fs electron bunches for laser-driven plasma acceleration at SINBAD

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, J., E-mail: jun.zhu@desy.de [Deutsches Elektronen-Synchrotron, DESY, Hamburg (Germany); Universität Hamburg, Hamburg (Germany); Assmann, R.W.; Dorda, U.; Marchetti, B. [Deutsches Elektronen-Synchrotron, DESY, Hamburg (Germany)

    2016-09-01

    We present theoretical and numerical studies of matching sub-femtosecond space-charge-dominated electron bunch into the Laser-plasma Wake Field Accelerator (LWFA) foreseen at the SINBAD facility. The longitudinal space-charge (SC) effect induced growths of the energy spread and longitudinal phase-space chirp are major issues in the matching section, which will result in bunch elongation, emittance growth and spot size dilution. In addition, the transverse SC effect would lead to a mismatch of the beam optics if it were not compensated for. Start-to-end simulations and preliminary optimizations were carried out in order to understand the achievable beam parameters at the entrance of the plasma accelerator.

  18. MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

    CERN Document Server

    Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

    2017-01-01

    During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

  19. Density bunching effects in a laser-driven, near-critical density plasma for ion acceleration

    Science.gov (United States)

    Ettlinger, Oliver; Sahai, Aakash; Hicks, George; Ditter, Emma-Jane; Dover, Nicholas; Chen, Yu-Hsin; Helle, Michael; Gordon, Daniel; Ting, Antonio; Polyanskiy, Mikhail; Pogorelsky, Igor; Babzien, Marcus; Najmudin, Zulfikar

    2016-10-01

    We present work investigating the interaction of relativistic laser pulses with near-critical density gas targets exhibiting pre-plasma scale lengths of several laser wavelengths. Analytical and computational modelling suggest that the interaction dynamics in a low-Z plasma is a direct result of induced density bunching up to the critical surface. In fact, these bunches can themselves become overcritical and experience significant radiation pressure, accelerating ions to higher energies compared to an ``idealised'' plasma slab target. This work will be used to help explain the observation of ion energies exceeding those predicted by radiation pressure driven hole-boring in recent experiments using the TW CO2 laser at the Accelerator Test Facility at Brookhaven National Laboratory.

  20. Late-time structure of the Bunch-Davies de Sitter wavefunction

    Science.gov (United States)

    Anninos, Dionysios; Anous, Tarek; Freedman, Daniel Z.; Konstantinidis, George

    2015-11-01

    We examine the late time behavior of the Bunch-Davies wavefunction for interacting light fields in a de Sitter background. We use perturbative techniques developed in the framework of AdS/CFT, and analytically continue to compute tree and loop level contributions to the Bunch-Davies wavefunction. We consider self-interacting scalars of general mass, but focus especially on the massless and conformally coupled cases. We show that certain contributions grow logarithmically in conformal time both at tree and loop level. We also consider gauge fields and gravitons. The four-dimensional Fefferman-Graham expansion of classical asymptotically de Sitter solutions is used to show that the wavefunction contains no logarithmic growth in the pure graviton sector at tree level. Finally, assuming a holographic relation between the wavefunction and the partition function of a conformal field theory, we interpret the logarithmic growths in the language of conformal field theory.

  1. Coherent synchrotron radiation and bunch stability in a compact storage ring

    Directory of Open Access Journals (Sweden)

    Marco Venturini

    2005-01-01

    Full Text Available We examine the effect of the collective force due to coherent synchrotron radiation (CSR in an electron storage ring with small bending radius. In a computation based on time-domain integration of the nonlinear Vlasov equation, we find the threshold current for a longitudinal microwave instability induced by CSR alone. The model accounts for suppression of radiation at long wavelengths due to shielding by the vacuum chamber. In a calculation just above threshold, small ripples in the charge distribution build up over a fraction of a synchrotron period, but then die out to yield a relatively smooth but altered distribution with eventual oscillations in bunch length. The instability evolves from small noise on an initial smooth bunch of rms length much greater than the shielding cutoff.

  2. High quality electron bunch generation with CO2-laser plasma accelerator

    CERN Document Server

    Zhang, L G; Xu, J C; Ji, L L; Zhang, X M; Wang, W P; Zhao, X Y; Yi, L Q; Yu, Y H; Shi, Y; Xu, T J; Xu, Z Z

    2014-01-01

    CO2 laser-driven electron acceleration is demonstrated with particle-in-cell simulation in low-density plasma. An intense CO2 laser pulse with long wavelength excites wakefield. The bubble behind it has a broad space to sustain a large amount of electrons before reaching its charge saturation limit. A transversely propagating inject pulse is used to induce and control the ambient electron injection. The accelerated electron bunch with total charge up to 10 nC and the average charge per energy interval of more than 0.6 nC/MeV are obtained. Plasma-based electron acceleration driven by intense CO2 laser provides a new potential way to generate high-charge electron bunch with low energy spread, which has broad applications, especially for X-ray generation by table-top FEL and bremsstrahlung.

  3. A linear radiofrequency quadrupole ion trap for the cooling and bunching of radioactive ion beams

    CERN Document Server

    Kellerbauer, A G; Dilling, J; Henry, S; Herfurth, F; Kluge, H J; Lamour, E; Moore, R B; Scheidenberger, C; Schwarz, S; Sikler, G; Szerypo, J

    2002-01-01

    A linear radiofrequency quadrupole ion guide and beam buncher has been installed at the ISOLTRAP mass spectrometry experiment at the ISOLDE facility at CERN. The apparatus is being used as a beam cooling, accumulation, and bunching system. It operates with a buffer gas that cools the injected ions and converts the quasicontinuous 60- keV beam from the ISOLDE facility to 2.5-keV beam pulses with improved normalized transverse emittance. Recent measurements suggest a capture efficiency of the ion guide of up to 40% and a cooling and bunching efficiency of at least 12% which is expected to still be increased. The improved ISOLTRAP setup has so far been used very successfully in three on-line experiments. (12 refs).

  4. Preparation And Characterization Of Cr/Activated Carbon Catalyst From Palm Empty Fruit Bunch

    OpenAIRE

    Zainal Fanani; Dedi Rohendi; Tri Kurnia Dewi; Muhammad Dzulfikar A

    2016-01-01

    Preparation and characterization of Cr/activated carbon catalyst from palm empty fruit bunch had been done. The research were to determine the effect of carbonization temperature towards adsorption of ammonia, iodine number, metilen blue number, and porosity of activated carbon and Cr/activated carbon catalyst. The determination of porosity include surface area, micropore volume and total pore volume. The results showed the best carbonization temperature activated carbon and Cr/activated carb...

  5. Properties of Lignin from Oil Palm Empty Fruit Bunch and Its Application for Plywood Adhesive

    OpenAIRE

    Lucky Risanto; Euis Hermiati; Yanni Sudiyani

    2014-01-01

    Lignin from lignocellulosic biomass is a potential biopolymer for wood adhesive. The aims of this study were to characterize lignin isolated from the black liquor of oil palm empty fruit bunch fiber pretreated with steam explosion in alkaline conditions and to examine the bond quality of aqueous polymer isocyanate (API) adhesive prepared from lignin, natural rubber latex (NRL), and polyvinyl alcohol (PVA) as base polymers with isocyanate crosslinkers. Lignin was precipitated from the black li...

  6. Centroid theory of transverse electron-proton two-stream instability in a long proton bunch

    OpenAIRE

    Tai-Sen F. Wang; Channell, Paul J.; Robert J. Macek; Davidson, Ronald C.

    2003-01-01

    This paper presents an analytical investigation of the transverse electron-proton (e-p) two-stream instability in a proton bunch propagating through a stationary electron background. The equations of motion, including damping effects, are derived for the centroids of the proton beam and the electron cloud by considering Lorentzian and Gaussian frequency spreads for the particles. For a Lorentzian frequency distribution, we derive the asymptotic solution of the coupled linear centroid equation...

  7. Improved ramped bunch train to increase the transformer ratio of a two-channel multimode dielectric wakefield accelerator

    Directory of Open Access Journals (Sweden)

    G. V. Sotnikov

    2011-03-01

    Full Text Available Here we show a possibility of applying the ramped drive bunch train (RBT technique to a two-channel coaxial dielectric wakefield accelerator (CDWA. For numerical research we study a 28 GHz structure with two nested alumina cylindrical shells having these diameters: outer shell, OD=28.1  mm, ID=27  mm; inner shell, OD=6.35  mm, ID=4.0  mm. The structure is to be excited by a train of four annular bunches having energy 14 MeV and axial rms length 1 mm; the total charge of bunches is 200 nC. In the case of equally charged drive bunches, spaced apart by the principal wakefield wavelength 10.67 mm, we obtained transformer ratio T=3.4. If the bunch charge is increasing as the ratio 1∶3∶5∶7 and the bunches are spaced by one and one-half wavelengths, we obtained T=3.8. We found that if the charge ratios are 1.0∶2.4∶3.5∶5.0 and the spaces between the bunches are 2.5, 2.5, and 4.5 wakefield periods, then T increases strongly, T∼20. The RBT also can be used successfully in a high gradient THz CDWA structure. A particle-in-cell simulation shows that the four drive bunches can move without appreciable distortion.

  8. Electron Cloud Cyclotron Resonances in the Presence of a Short-bunch-length Relativistic Beam

    Energy Technology Data Exchange (ETDEWEB)

    Celata, C.M.; Furman, Miguel A.; Vay, J.-L.; Yu, Jennifer W.

    2008-09-02

    Computer simulations using the 2D code"POSINST" were used to study the formation of the electron cloud in the wiggler section of the positron damping ring of the International Linear Collider. In order to simulate an x-y slice of the wiggler (i.e., a slice perpendicular to the beam velocity), each simulation assumed a constant vertical magnetic field. At values of the magnetic field where the cyclotron frequency was an integral multiple of the bunch frequency, and where the field strength was less than approximately 0.6 T, equilibrium average electron densities were up to three times the density found at other neighboring field values. Effects of this resonance between the bunch and cyclotron frequency are expected to be non-negligible when the beam bunch length is much less than the product of the electron cyclotron period and the beam velocity, for a beam moving at v~;;c. Details of the dynamics of the resonance are described.

  9. Electron beam bunch length characterizations using incoherent and coherent radiation on the APS SASE FEL project.

    Energy Technology Data Exchange (ETDEWEB)

    Berg, W. J.; Happek, U.; Lewellen, J. W.; Lumpkin, A. H.; Sereno, N. S.; Yang, B. X.

    1999-08-28

    The Advanced Photon Source (APS) injector linac has been reconfigured with a low-emittance rf thermionic gun and a photocathode (PC) rf gun to support self-amplified spontaneous emission (SASE) free-electron laser (FEL) experiments. One of the most critical parameters for optimizing SASE performance (gain length) is the electron beam peak current, which requires a charge measurement and a bunch length measurement capability. We report here initial measurements of the latter using both incoherent optical transition radiation (OTR) and coherent transition radiation (CTR), A visible light Hamarnatsu C5680 synchroscan streak camera was used to measure the thermionic rf gun beam's bunch length ({sigma} {approximately}2 to 3ps) via OTR generated by the beam at 220 MeV and 200 mA macropulse average current. In addition, a CTR monitor (Michelson Interferometer) based on a Golay cell as the far infrared (FIR) detector has been installed at the 40-MeV station in the beamline. Initial observation s of CTR signal strength variation with gun a-magnet current and interferograms have been obtained. Progress in characterizing the beam at these locations and a comparison to other bunch length determinations will be presented.

  10. A compact radio frequency quadrupole for ion bunching in the WITCH experiment

    CERN Document Server

    Traykov, E.; Breitenfeldt, M.; Delahaye, P.; De Leebeeck, V.; Friedag, P.; Herlert, A.; Geeraert, N.; Heirman, W.; Lonne, P.I.; Mader, J.; Roccia, S.; Soti, G.; Tandecki, M.; Timmermans, M.; Thiboud, J.; Van Gorp, S.; Wauters, F.; Weinheimer, C.; Zakoucky, D.; Severijns, N.

    2011-01-01

    During the last several years the WITCH (Weak Interaction Trap for CHarged particles) experimental setup at ISOLDE has undergone various upgrades aiming at improvement of general performance. An essential innovation, a compact Radio Frequency Quadrupole (RFQ) ion cooler and buncher device, was designed and successfully commissioned as a part of the off-line tuning system of WITCH. The RFQ is coupled to the existing surface ionization ion source providing high intensity ion bunches (up to 10(7) ions per bunch) towards the pulsed drift tube and the Penning traps of WITCH. This achievement allows for loading and tuning of the Penning traps in the domain of space charge limits and grants off-line operation independently of the REX-ISOLDE ion source. The current upgrade allows for a more thorough and frequent testing with bunched stable ion beams of high intensities, which will be used for studying various systematic effects involved in experiments with radioactive ions. (C) 2011 Elsevier B.V. All rights reserved.

  11. Pulse length of ultracold electron bunches extracted from a laser cooled gas

    Science.gov (United States)

    Franssen, J. G. H.; Frankort, T. L. I.; Vredenbregt, E. J. D.; Luiten, O. J.

    2017-01-01

    We present measurements of the pulse length of ultracold electron bunches generated by near-threshold two-photon photoionization of a laser-cooled gas. The pulse length has been measured using a resonant 3 GHz deflecting cavity in TM110 mode. We have measured the pulse length in three ionization regimes. The first is direct two-photon photoionization using only a 480 nm femtosecond laser pulse, which results in short (∼15 ps) but hot (∼104 K) electron bunches. The second regime is just-above-threshold femtosecond photoionization employing the combination of a continuous-wave 780 nm excitation laser and a tunable 480 nm femtosecond ionization laser which results in both ultracold (∼10 K) and ultrafast (∼25 ps) electron bunches. These pulses typically contain ∼103 electrons and have a root-mean-square normalized transverse beam emittance of 1.5 ± 0.1 nm rad. The measured pulse lengths are limited by the energy spread associated with the longitudinal size of the ionization volume, as expected. The third regime is just-below-threshold ionization which produces Rydberg states which slowly ionize on microsecond time scales. PMID:28396879

  12. COMPENSATION FOR BUNCH EMITTANCE IN A MAGNETIZATION AND SPACE CHARGE DOMINATED BEAM.

    Energy Technology Data Exchange (ETDEWEB)

    CHANG,X.; BEN-ZVI,I.; KEWISCH,J.

    2004-06-21

    In order to obtain sufficient cooling rates for the Relativistic Heavy Ion Collider (RHIC) electron cooling, a bunched beam with high bunch charge, high repetition frequency and high energy is required and it is necessary to use a ''magnetized'' beam, i.e., an electron beam with non-negligible angular momentum. Applying a longitudinal solenoid field on the cathode can generate such a beam, which rotates around its longitudinal axis in a field-free region. This paper suggests how a magnetized beam can be accelerated and transported from a RF photocathode electron gun to the cooling section without significantly increasing its emittance. The evolution of longitudinal slices of the beam under a combination of space charge and magnetization is investigated, using paraxial envelope equations and numerical simulations. We find that we must modify the traditional method of compensating for emittance as used for normal non-magnetized beam with space charge to account for magnetization. The results of computer simulations of successful compensation are presented. Alternately, we show an electron bunch density distribution for which all slices propagate uniformly and which does not require emittance compensation.

  13. Measurement of self-shaped ellipsoidal bunches from a photoinjector with postacceleration

    Directory of Open Access Journals (Sweden)

    Brendan O’Shea

    2011-01-01

    Full Text Available Recent work has shown the possibility of generating self-shaped ellipsoidal beams with properties commensurate with the requirements of future light sources such as free-electron lasers and inverse Compton sources. In this so-termed “blowout” regime, short laser bunches are transformed via photoemission into short electron bunches which then self-consistently evolve into nearly uniform-density ellipsoids under space-charge forces. We report here on the first blowout studies conducted in collaboration between the UCLA Particle Beam Physics Lab and the Photo Injector Test Facility, Zeuthen (PITZ. The measurements conducted at the PITZ photoinjector facility examine the evolution of 750 pC, 2.7 ps FWHM electron bunches born in an L-band photoinjector and subsequently accelerated through a nine-cell L-band booster for a resulting energy of 12 MeV. These measurements represent the first observations of self-shaped ellipsoid evolution under postinjector acceleration, a key step in demonstrating the utility of such self-shaped beams at higher energy, where the advantages in both transverse and longitudinal and transverse phase space may be exploited in creating very high brightness beams.

  14. Initial Measurements of CSR from a Bunch-Compressed Beam at APS

    CERN Document Server

    Lumpkin, Alex H; Borland, M; Sereno, N S

    2005-01-01

    The interest in bunch compression to generate higher peak current electron beams with low emittance continues in the free-electron laser (FEL) community. At the Advanced Photon source (APS) we have both an rf thermionic gun and an rf photocathode (PC) gun on the S-band linac. At the 150-MeV point in the linac, we have a flexible chicane bunch compressor whose four dipoles bend the beam in the horizontal plane. There is also a vertical bend dipole after the chicane that allows measurement of energy and horizontal beam size at the imaging screen station to study possible effects on emittance due to coherent synchrotron radiation (CSR) in the chicane. A far-infrared (FIR) coherent radiation monitor is located downstream of the chicane as well. We have begun recommissioning of this device with coherent transition radiation (CTR), but we also have directly observed CSR from the bunch-compressed beam as it transits the vertical dipole and goes into the down leg. The unique geometry allows simultaneous tracking of b...

  15. Emittance growth due to static and radiative space charge forces in an electron bunch compressor

    CERN Document Server

    Talman, Richard; Stulle, Frank

    2009-01-01

    Evolution of short intense electron bunches passing through bunch-compressing beam lines is studied using the UAL (Unified Accelerator Libraries) string space charge formulation [R. Talman, Phys. Rev. ST Accel. Beams 7, 100701 (2004); N. Malitsky and R. Talman, in Proceedings of the 9th European Particle Accelerator Conference, Lucerne, 2004 (EPS-AG, Lucerne, 2004); R. Talman, Accelerator X-Ray Sources (Wiley-VCH, Weinheim, 2006), Chap. 13]. Three major configurations are studied, with the first most important and studied in greatest detail (because actual experimental results are available and the same results have been simulated with other codes): (i) Experimental bunch compression results were obtained at CTF-II, the CERN test facility for the “Compact Linear Collider” using electrons of about 40 MeV. Previous simulations of these results have been performed (using trafic4* [A. Kabel et al., Nucl. Instrum. Methods Phys. Res., Sect. A 455, 185 (2000)] and elegant [M. Borland, Argonne National Laboratory...

  16. Analysis of the electron cloud observations with 25 ns bunch spacing at LHC

    CERN Document Server

    Iadarola, G; Rumolo, G; Arduini, G; Baglin, V; Banfi, D; Claudet, S; Dominguez, O; Esteban Müller, J; Pieloni, T; Shaposhnikova, E; Tavian, L; Zannini, C; Zimmermann, F

    2014-01-01

    Electron Cloud (EC) effects have been identified as a major performance limitation for the Large Hadron Collider (LHC) when operating with the nominal bunch spacing of 25 ns. During the LHC Run 1 (2010 - 2013) the luminosity production mainly used beams with 50 ns spacing, while 25 ns beams were only employed for short periods in 2011 and 2012 for test purposes. On these occasions, observables such as pressure rise, heat load in the cold sections as well as clear signatures on bunch-by-bunch emittance blow up, particle loss and energy loss indicated the presence of an EC in a large portion of the LHC. The analysis of the recorded data, together with EC build up simulations, has led to a significant improvement of our understanding of the EC effect in the different components of the LHC. Studies were carried out both at injection energy (450 GeV) and at top energy (4 TeV) aiming at determining the energy dependence of the EC formation and its impact on the quality of the proton beam.

  17. Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus

    Directory of Open Access Journals (Sweden)

    Kátia Luz Torres

    2014-07-01

    Full Text Available OBJECTIVE: With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e Hemoterapia do Amazonas and evaluate the efficacy of rapid diagnostic tests used for malaria screening of blood donors within endemic regions. METHODS: Between May 2008 and May 2009, 407 blood donor candidates were selected and grouped based on the Malaria Annual Parasite Index of the geographic area in which they originated: Group 1 (eligible donors - n = 265 originated from areas of low to medium risk of exposure to malaria and Group 2 (ineligible donors - n = 142 originated from high-risk areas. All samples were concurrently screened using two immunochromatic antigen-based rapid tests and by the thick smear test. RESULTS: All samples were negative by all three methods. The demographic profile indicated that the majority of participants were male, ages ranged from 18 to 39 years and less than half the candidates had only elementary schooling. Two issues need to be addressed: one is the ineligibility of donors and its impact on blood donor centers as, in this study, 22.7% of the donors were considered ineligible. The other is the limited sensitivity of the parasitological tests used, allowing a risk of false-negative results. CONCLUSION: New methods are needed to ensure transfusion safety without rejecting potential donors, which would ensure safe transfusion without harming the blood supply.

  18. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease.

    Science.gov (United States)

    Emoto, Takuo; Yamashita, Tomoya; Kobayashi, Toshio; Sasaki, Naoto; Hirota, Yushi; Hayashi, Tomohiro; So, Anna; Kasahara, Kazuyuki; Yodoi, Keiko; Matsumoto, Takuya; Mizoguchi, Taiji; Ogawa, Wataru; Hirata, Ken-Ichi

    2017-01-01

    The association between atherosclerosis and gut microbiota has been attracting increased attention. We previously demonstrated a possible link between gut microbiota and coronary artery disease. Our aim of this study was to clarify the gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism (T-RFLP). This study included 39 coronary artery disease (CAD) patients and 30 age- and sex- matched no-CAD controls (Ctrls) with coronary risk factors. Bacterial DNA was extracted from their fecal samples and analyzed by T-RFLP and data mining analysis using the classification and regression algorithm. Five additional CAD patients were newly recruited to confirm the reliability of this analysis. Data mining analysis could divide the composition of gut microbiota into 2 characteristic nodes. The CAD group was classified into 4 CAD pattern nodes (35/39 = 90 %), while the Ctrl group was classified into 3 Ctrl pattern nodes (28/30 = 93 %). Five additional CAD samples were applied to the same dividing model, which could validate the accuracy to predict the risk of CAD by data mining analysis. We could demonstrate that operational taxonomic unit 853 (OTU853), OTU657, and OTU990 were determined important both by the data mining method and by the usual statistical comparison. We classified the gut microbiota profiles in coronary artery disease patients using data mining analysis of T-RFLP data and demonstrated the possibility that gut microbiota is a diagnostic marker of suffering from CAD.

  19. Transfusion-transmitted malaria in endemic zone: epidemiological profile of blood donors at the Fundação HEMOAM and use of rapid diagnostic tests for malaria screening in Manaus.

    Science.gov (United States)

    Torres, Kátia Luz; Dos Santos Moresco, Mônica Nascimento; Sales, Luciane Rodrigues; da Silva Abranches, Josilene; Araújo Alexandre, Márcia Almeida; Malheiro, Adriana

    2014-01-01

    With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e Hemoterapia do Amazonas and evaluate the efficacy of rapid diagnostic tests used for malaria screening of blood donors within endemic regions. Between May 2008 and May 2009, 407 blood donor candidates were selected and grouped based on the Malaria Annual Parasite Index of the geographic area in which they originated: Group 1 (eligible donors - n=265) originated from areas of low to medium risk of exposure to malaria and Group 2 (ineligible donors - n=142) originated from high-risk areas. All samples were concurrently screened using two immunochromatic antigen-based rapid tests and by the thick smear test. All samples were negative by all three methods. The demographic profile indicated that the majority of participants were male, ages ranged from 18 to 39 years and less than half the candidates had only elementary schooling. Two issues need to be addressed: one is the ineligibility of donors and its impact on blood donor centers as, in this study, 22.7% of the donors were considered ineligible. The other is the limited sensitivity of the parasitological tests used, allowing a risk of false-negative results. New methods are needed to ensure transfusion safety without rejecting potential donors, which would ensure safe transfusion without harming the blood supply. Copyright © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.

  20. Companion diagnostics

    DEFF Research Database (Denmark)

    Jørgensen, Jan Trøst; Hersom, Maria

    2016-01-01

    . Despite having discussed personalized medicine for more than a decade, we still see that most drug prescriptions for severe chronic diseases are largely based on 'trial and error' and not on solid biomarker data. However, with the advance of molecular diagnostics and a subsequent increased understanding...

  1. Chemical profiling of Re-Du-Ning injection by ultra-performance liquid chromatography coupled with electrospray ionization tandem quadrupole time-of-flight mass spectrometry through the screening of diagnostic Ions in MS(E mode.

    Directory of Open Access Journals (Sweden)

    Haibo Li

    Full Text Available The broad applications and mechanism explorations of traditional Chinese medicine prescriptions (TCMPs require a clear understanding of TCMP chemical constituents. In the present study, we describe an efficient and universally applicable analytical approach based on ultra-performance liquid chromatography coupled to electrospray ionization tandem quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q/TOF-MS with the MS(E ((E denotes collision energy data acquisition mode, which allowed the rapid separation and reliable determination of TCMP chemical constituents. By monitoring diagnostic ions in the high energy function of MS(E, target peaks of analogous compounds in TCMPs could be rapidly screened and identified. "Re-Du-Ning" injection (RDN, a eutherapeutic traditional Chinese medicine injection (TCMI that has been widely used to reduce fever caused by viral infections in clinical practice, was studied as an example. In total, 90 compounds, including five new iridoids and one new sesquiterpene, were identified or tentatively characterized by accurate mass measurements within 5 ppm error. This analysis was accompanied by MS fragmentation and reference standard comparison analyses. Furthermore, the herbal sources of these compounds were unambiguously confirmed by comparing the extracted ion chromatograms (EICs of RDN and ingredient herbal extracts. Our work provides a certain foundation for further studies of RDN. Moreover, the analytical approach developed herein has proven to be generally applicable for profiling the chemical constituents in TCMPs and other complicated mixtures.

  2. O perfil do médico em formação em radiologia e diagnóstico por imagem Profile of the physician undergoing education in radiology and diagnostic imaging

    Directory of Open Access Journals (Sweden)

    Glauce Cerqueira Corrêa da Silva

    2007-04-01

    Full Text Available OBJETIVO: Identificar diferenças no perfil psicossocial do especializando e médico residente em radiologia e diagnóstico por imagem, avaliar a aspiração profissional e as motivações internas que os influenciaram a escolher a especialidade radiologia e diagnóstico por imagem e se o nível de satisfação profissional melhora a relação médico-paciente. MATERIAIS E MÉTODOS: Foi aplicado um questionário com 26 perguntas que constava também do teste de auto-estima de Rosenberg. RESULTADOS: A auto-estima está acima da média para 39,6% dos médicos. Para 38,7% dos alunos, a escolha da medicina se deu por aptidão ou realizações pessoais. Para 50,9% dos médicos entrevistados, os clientes compreendem e assimilam as informações transmitidas. Apresentam condições para esclarecer as dúvidas dos pacientes 77,4% dos médicos. CONCLUSÃO: Não há diferença no perfil psicossocial do especializando e do médico residente em radiologia e diagnóstico por imagem. A aspiração profissional e as motivações internas dos médicos residentes e especializandos têm as mesmas influências na escolha da especialidade. Os médicos residentes estão mais preparados para o envolvimento na relação médico-paciente do que os especializandos.OBJECTIVE: To identify differences in the psychosocial profile of medical trainees and residents in radiology and diagnostic imaging, to evaluate the professional aspirations and inner motivation driving their choice of the specialty of radiology and diagnostic imaging, as well as whether their professional satisfaction level improves the doctor-patient relationship. MATERIALS AND METHODS: A 26-question questionnaire including the Rosenberg's self-esteem scale was completed by medical trainees and residents. RESULTS: Self-esteem is above average for 39.6% of the respondents; aptitude for medicine or personal realization has motivated the choice of 38.7% of the students; for 50.9% of the respondents, the

  3. Emittance growth due to static and radiative space charge forces in an electron bunch compressor

    Directory of Open Access Journals (Sweden)

    Richard Talman

    2009-01-01

    Full Text Available Evolution of short intense electron bunches passing through bunch-compressing beam lines is studied using the UAL (Unified Accelerator Libraries string space charge formulation [R. Talman, Phys. Rev. ST Accel. Beams 7, 100701 (2004PRABFM1098-440210.1103/PhysRevSTAB.7.100701; N. Malitsky and R. Talman, in Proceedings of the 9th European Particle Accelerator Conference, Lucerne, 2004 (EPS-AG, Lucerne, 2004; R. Talman, Accelerator X-Ray Sources (Wiley-VCH, Weinheim, 2006, Chap. 13]. Three major configurations are studied, with the first most important and studied in greatest detail (because actual experimental results are available and the same results have been simulated with other codes: (i Experimental bunch compression results were obtained at CTF-II, the CERN test facility for the “Compact Linear Collider” using electrons of about 40 MeV. Previous simulations of these results have been performed (using TraFiC4* [A. Kabel et al., Nucl. Instrum. Methods Phys. Res., Sect. A 455, 185 (2000NIMAER0168-900210.1016/S0168-9002(0000729-4] and ELEGANT [M. Borland, Argonne National Laboratory Report No. LS-287, 2000]. All three simulations are in fair agreement with the data except that the UAL simulation predicts a substantial dependence of horizontal emittance ϵ_{x} on beam width (as controlled by the lattice β_{x} function at the compressor location. This is consistent with the experimental observations, but inconsistent with other simulations. Excellent agreement concerning dependence of bunch energy loss on bunch length and magnetic field strength [L. Groening et al., in Proceedings of the Particle Accelerator Conference, Chicago, IL, 2001 (IEEE, New York, 2001, http://groening.home.cern/groening/csr_00.htm] confirms our understanding of the role played by coherent synchrotron radiation (CSR. (ii A controlled comparison is made between the predictions of the UAL code and those of CSRTrack [M. Dohlus and T. Limberg, in Proceedings of the

  4. Beamstrahlung simulation and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Ziemann, V.

    1991-06-01

    A simulation code that models the mutual deflection and the emission of beamstrahlung of two ultra-relativistic electron and positron bunches is described. The simulations are used to determine transverse beam sizes from observed beamstrahlung fluxes. 8 refs., 3 figs.

  5. Diagnostic Challenges at SNS

    CERN Document Server

    Plum, M A

    2003-01-01

    The Spallation Neutron Source now being built in Oak Ridge, Tennessee, USA, accelerates an H- ion beam to 1000 MeV with an average power of 1.4 MW. The H- beam is then stripped to H+, compressed in a storage ring to a pulse length of 695 ns, and then directed onto a mercury neutron spallation target. Most of the acceleration is accomplished with superconducting rf cavities. The presence of these cavities, the high average beam power, and the large range of beam intensity in the storage ring, provide unique challenges to the beam diagnostics systems. In this talk we will discuss these challenges and some of our solutions, including the laser profile monitor system, the residual gas ionization profile monitors, and network attached devices. Measurements performed using prototype instrumentation will also be presented.

  6. Synthesis and photoluminescence property of La doped Pb{sub 5}(VO{sub 4}){sub 3}OH rod bunches

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jing; Zhuo, Fengping; Fu, Ya; Wang, Yue; Yuan, Jinhai, E-mail: materialscqust@126.com; Feng, Jian

    2017-05-10

    The pure Pb{sub 5}(VO{sub 4}){sub 3}OH and La doped Pb{sub 5}(VO{sub 4}){sub 3}OH rod bunches have been synthesized by a simple Composite-Hydroxide-Mediated (CHM) method. The characterization of the doped samples with XRD, EDS and XPS indicated that La{sup 3+} ions were incorporated into the Pb{sub 5}(VO{sub 4}){sub 3}OH lattices. The crystallite size of Pb{sub 5}(VO{sub 4}){sub 3}OH:La{sup 3+} rod bunches was smaller than that of pure Pb{sub 5}(VO{sub 4}){sub 3}OH rod bunches. The possible formation mechanism of rod bunches has been discussed. The photoluminescence property of the Pb{sub 5}(VO{sub 4}){sub 3}OH:La{sup 3+} crystals was investigated at room temperature. The crystals exhibited a strong blue luminescence under UV light (353 nm) excitation at room-temperature. The mechanism of excellent luminescence of Pb{sub 5}(VO{sub 4}){sub 3}OH:La{sup 3+} has been deeply discussed. - Highlights: • Pb{sub 5}(VO{sub 4}){sub 3}OH:La{sup 3+} rod bunches have been synthesized by the CHM method. • The possible formation mechanism of rod bunches has been discussed. • The La{sup 3+} doping in the Pb{sub 5}(VO{sub 4}){sub 3}OH rod bunches can improve the blue luminescence property at room temperature remarkably.

  7. Far infrared fusion plasma diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Luhmann, N.C. Jr.; Peebles, W.A.

    1990-01-01

    Over the last several years, reflectometry has grown in importance as a diagnostic for both steady-state density Profiles as well as for the investigation of density fluctuations and turbulence. As a diagnostic for density profile measurement, it is generally believed to be well understood in the tokamak environment. However, its use as a fluctuation diagnostic is hampered by a lack of quantitative experimental understanding of its wavenumber sensitivity and spatial resolution. Several researchers, have theoretically investigated these questions. However, prior to the UCLA laboratory investigation, no group has experimentally investigated these questions. Because of the reflectometer's importance to the world effort in understanding plasma turbulence and transport, UCLA has, over the last year, made its primary Task IIIA effort the resolution of these questions. UCLA has taken the lead in a quantitative experimental understanding of reflectometer data as applied to the measurement of density fluctuations. In addition to this, work has proceeded on the design, construction, and installation of a reflectometer system on UCLA's CCT tokamak. This effort will allow a comparison between the improved confinement regimes (H-mode) observed on both the DIII-D and CCT machines with the goal of achieving a physics understanding of the phenomena. Preliminary investigation of a new diagnostic technique to measure density profiles as a function of time has been initiated at UCLA. The technique promises to be a valuable addition to the range of available plasma diagnostics. Work on advanced holographic reflectometry technique as applied to fluctuation diagnostics has awaited a better understanding of the reflectometer signal itself as discussed above. Efforts to ensure the transfer of the diagnostic developments have continued with particular attention devoted to the preliminary design of a multichannel FIR interferometer for MST.

  8. Theoretical analysis and simulation of the influence of self-bunching effects and longitudinal space charge effects on the propagation of keV electron bunch produced by a novel S-band Micro-Pulse electron Gun

    Directory of Open Access Journals (Sweden)

    Jifei Zhao

    2016-06-01

    Full Text Available As an important electron source, Micro-Pulse electron Gun (MPG which is qualified for producing high average current, short pulse, low emittance electron bunches steadily holds promise to use as an electron source of Coherent Smith-Purcell Radiation (CSPR, Free Electron Laser (FEL. The stable output of S-band MPG has been achieved in many labs. To establish reliable foundation for the future application of it, the propagation of picosecond electron bunch produced by MPG should be studied in detail. In this article, the MPG which was working on the rising stage of total effective Secondary Electron Yield (SEY curve was introduced. The self-bunching mechanism was discussed in depth both in the multipacting amplifying state and the steady working state. The bunch length broadening induced by the longitudinal space-charge (SC effects was investigated by different theoretical models in different regions. The 2D PIC codes MAGIC and beam dynamic codes TraceWin simulations were also performed in the propagation. The result shows an excellent agreement between the simulation and the theoretical analysis for bunch length evolution.

  9. Long bunch trains measured using a prototype cavity beam position monitor for the Compact Linear Collider

    Directory of Open Access Journals (Sweden)

    F. J. Cullinan

    2015-11-01

    Full Text Available The Compact Linear Collider (CLIC requires beam position monitors (BPMs with 50 nm spatial resolution for alignment of the beam line elements in the main linac and beam delivery system. Furthermore, the BPMs must be able to make multiple independent measurements within a single 156 ns long bunch train. A prototype cavity BPM for CLIC has been manufactured and tested on the probe beam line at the 3rd CLIC Test Facility (CTF3 at CERN. The transverse beam position is determined from the electromagnetic resonant modes excited by the beam in the two cavities of the pickup, the position cavity and the reference cavity. The mode that is measured in each cavity resonates at 15 GHz and has a loaded quality factor that is below 200. Analytical expressions for the amplitude, phase and total energy of signals from long trains of bunches have been derived and the main conclusions are discussed. The results of the beam tests are presented. The variable gain of the receiver electronics has been characterized using beam excited signals and the form of the signals for different beam pulse lengths with the 2/3  ns bunch spacing has been observed. The sensitivity of the reference cavity signal to charge and the horizontal position signal to beam offset have been measured and are compared with theoretical predictions based on laboratory measurements of the BPM pickup and the form of the resonant cavity modes as determined by numerical simulation. Finally, the BPM was calibrated so that the beam position jitter at the BPM location could be measured. It is expected that the beam jitter scales linearly with the beam size and so the results are compared to predicted values for the latter.

  10. High Charge PHIN Photo Injector at CERN with Fast Phase switching within the Bunch Train for Beam Combination

    CERN Document Server

    Csatari Divall, M; Bolzon, B; Bravin, E; Chevallay, E; Dabrowski, A; Doebert, S; Drozdy, A; Fedosseev, V; Hessler, C; Lefevre, T; Livesley, S; Losito, R; Olvegaard, M; Petrarca, M; Rabiller, A N; Egger, D; Mete, O

    2011-01-01

    The high charge PHIN photo-injector was developed within the framework of the European CARE program to provide an alternative to the drive beam thermionic gun in the CTF3 (CLIC Test Facility) at CERN. In PHIN 1908 electron bunches are delivered with bunch spacing of 1.5 GHz and 2.33 nC charge per bunch. Furthermore the drive beam generated by CTF3 requires several fast 180 deg phase-shifts with respect to the 1.5 GHz bunch repetition frequency in order to allow the beam combination scheme developed at CTF3. A total of 8 subtrains, each 140 ns long and shifted in phase with respect to each other, have to be produced with very high phase and amplitude stability. A novel fiber modulator based phase-switching technique developed on the laser system provides this phase-shift between two consecutive pulses much faster and cleaner than the base line scheme, where a thermionic electron gun and sub-harmonic bunching are used. The paper describes the fiber-based switching system and the measurements verifying the schem...

  11. Generation of high brightness electron beam by brake-applied velocity bunching with a relatively low energy chirp

    Science.gov (United States)

    Huang, Ruixuan; He, Zhigang; Li, Biaobin; Zhang, Shancai; Li, Weiwei; Jia, Qika; Wang, Lin

    2017-09-01

    Velocity bunching technique is a tool for compressing electron beams in modern high brightness photoinjector sources, which utilizes the velocity difference introduced by a traveling rf wave at a relatively low energy. It presents peculiar challenges when applied to obtain a beam with a very high current and a low transverse emittance in photoinjectors. The main difficulty is to control the emittance oscillations of the beam during high compression, which can be naturally considered as an extension of the emittance compensation process. In this paper, a brake-applied velocity bunching scheme is proposed, in which the electron bunch is injected into the accelerator with a low gradient at a deceleration phase, like ;a brake is applied;, afterward slips to an acceleration phase. During the entire compression process, the energy chirp induced by the rf field is mostly linear, which retains a symmetric electron beam in the temporal distribution. The key point of the new scheme is a smaller energy chirp at a lower beam energy compared with the normal velocity bunching. Besides, the beam energy chirp before compression is dominated by the linear correlation due to a relatively short laser pulse. With a symmetric bunch compression, the transverse emittance could be compensated even if the compression factor is extremely high. As to our simulation results, the peak current of the compressed beam can be above 1.8 kA for the charge of 800 pC with a good emittance compensation.

  12. Energy loss and longitudinal wakefield of relativistic short proton bunches in electron clouds

    Directory of Open Access Journals (Sweden)

    O. Boine-Frankenheim

    2012-05-01

    Full Text Available The aim of our study is the numerical computation of the wakefield and energy loss per unit length for relativistic, short (<10  ns proton bunches interacting with an electron cloud inside the beam pipe. We present analytical expressions for the energy loss in the impulse kick approximation. For the simulation of the wakefields a 2D self-consistent, electrostatic particle-in-cell (PIC code is employed. Results for the energy loss and for the wakefields are presented for the parameter scope of the CERN LHC and SPS. For selected parameters the results are compared to a three-dimensional (3D electromagnetic PIC code.

  13. Double and triple-harmonic RF buckets and their use for bunch squeezing in AGS

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-08-24

    For the past several years we have merged bunches in AGS in order to achieve the desired intensity per bunch prior to injection into RHIC. The merging is done on a flat porch at or above AGS injection energy. Because the merges involve the reduction of the RF harmonic number by a factor of 2 (for a 2 to 1 merge) and then a factor of 3 (for a 3 to 1 merge), one requires RF frequencies 6hfs, 3hfs, 2hfs and hfs, where fs is the revolution frequency on the porch and h = 4 is the fundamental harmonic number. The standard AGS RF cavities cannot operate at the lowest frequencies 2hfs and hfs; these are provided by two modified cavities. Upon completion of the merges, the bunches are sitting in harmonic h buckets. In order to be accelerated they need to be squeezed into harmonic 3h buckets. This is accomplished by producing a double-harmonic bucket in which harmonics h and 2h act in concert, and then a triple-harmonic bucket in which harmonics h, 2h, and 3h act in concert. Simulations have shown that the squeeze presents an acceptance bottleneck which limits the longitudinal emittance that can be put into the harmonic 3h bucket. In this note the areas of the double and triple-harmonic buckets are calculated explicitly, and it is shown that these go through a minimum as the RF voltages are raised to the desired values. Several RF voltage ranges are examined, and the acceptance bottleneck is determined for each of these. Finally, the acceptance bottleneck for Au77+ bunches in AGS is calculated for several RF voltage ranges. The main result is that the RF voltages for the low-frequency harmonic h and 2h cavities both must be at least 22 kV in order to achieve an acceptance of 0:6 eV s per nucleon. If the harmonic h and 2h voltages are 15 and 22 kV, respectively, then the acceptance is reduced to 0:548 eV s per nucleon.

  14. Impact of Optics on CSR-Related Emittance Growth in Bunch Compressor Chicanes

    CERN Document Server

    Limberg, Torsten

    2005-01-01

    The dependence of emittance growth due to Coherent Synchrotron Radiation (CSR) in bunch compressor chicanes on optics has been noticed and empirically studied in the past. We revisit the subject, suggesting a model to explain slice emittance growth dependence on chicane optics. A simplified model to calculate projected emittance growth when it is mainly caused by transverse slice centroid offsets is presented. It is then used to find optimal compensation of centroid kicks in the single chicanes of a two-stage compression system by adjusting the phase advance of the transport in between and the ration of the compression factors.

  15. Mechanical and molecular studies of biocomposites filled with oil palm empty fruit bunches microfibers

    Science.gov (United States)

    Nikmatin, S.; Saepulloh, D. R.; Irmansyah; Syafiuddin, A.

    2017-05-01

    The present work aims to investigate mechanical and molecular characteristics of acrylonitrile butadiene styrene (ABS) composites filled with oil palm empty fruit bunches (OPEFB) microfibers. OPEFB microfibers were produced using mechanical milling. Composite granules were fabricated using single screw extruder. These composites were then used for fabricating helmet according to the Indonesian National Standard (SNI). Mechanical testing confirms that the helmet produced using this biocomposites are suitable to the SNI. Molecular interaction between matrix with OPEFB can be described using orbital hybridization theory. In general, this study has successfully investigated mechanical and molecular properties of the biocomposites.

  16. Chlorophyll fluorescence imaging for the noninvasive assessment of anthocyanins in whole grape (Vitis vinifera L.) bunches.

    Science.gov (United States)

    Agati, Giovanni; Traversi, Maria Laura; Cerovic, Zoran G

    2008-01-01

    The distribution of anthocyanins in grape (Vitis vinifera L.) bunches from the Sangiovese cultivar was measured nondestructively by chlorophyll fluorescence imaging using two excitation light bands at 550 and 650 nm in sequence. The pixel intensity in the derived logarithm of the fluorescence excitation ratio image was directly related, by an exponential function (r2 = 0.93), to the anthocyanin concentration of berry extracts. The method will be useful for the assessment of the heterogeneity of anthocyanin accumulation in berries that is known to depend on physiologic and climatic factors. It can also represent a new, rapid and noninvasive technique for the assessment of grape ripening and the appropriate time of harvest.

  17. Thyroid diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Scriba, P.C.; Boerner, W.; Emrich, S.; Gutekunst, R.; Herrmann, J.; Horn, K.; Klett, M.; Krueskemper, H.L.; Pfannenstiel, P.; Pickardt, C.R.

    1985-03-01

    None of the in-vitro and in-vivo methods listed permits on unambiguous diagnosis when applied alone, owing to the fact that similar or even identical findings are obtained for various individual parameters in different thyroid diseases. Further, especially the in-vitro tests are also subject to extrathyroidal effects which may mask the typical findings. The limited and varying specificity and sensitivity of the tests applied, as well as the falsification of results caused by the patients' idiosyncracies and the methodology, make it necessary to interpret and evaluate the in-vivo and in-vitro findings only if the clinical situation (anamnesis and physical examination) is known. For maximum diagnostic quality of the tests, the initial probability of the assumed type of thyroid disease must be increased (formulation of the clinical problem). The concepts of exclusion diagnosis and identification must be distinguished as well as the diagnosis of functional disturbances on the one hand and of thyroid diseases on the other. Both of this requires a qualified, specific and detailed anamnesis and examination procedure, and the clinical examination remains the obligatory basis of clinical diagnostics. In case of inexplicable discrepancies between the clinical manifestations and the findings obtained with specific methods, or between the findings obtained with a specific method, the patient should be referred to an expert institution, or the expert institution should be consulted.

  18. Ambient diagnostics

    CERN Document Server

    Cai, Yang

    2014-01-01

    Part I. FundamentalsIntroductionWhat is Ambient Diagnostics?Diagnostic ModelsMultimedia IntelligenceCrowd SourcingSoft SensorsScience of SimplicityPersonal DiagnosesBasic AlgorithmsBasic ToolsSummaryProblemsTransformationEarly Discoveries of Heartbeat PatternsTransforms, Features, and AttributesSequential FeaturesSpatiotemporal FeaturesShape FeaturesImagery FeaturesFrequency Domain FeaturesMulti-Resolution FeaturesSummaryProblemsPattern RecognitionSimilarities and DistancesClustering MethodsClassification MethodsClassifier Accuracy MeasuresSummaryProblemsPart II. Multimedia IntelligenceSound RecognitionMicrophone AppsModern Acoustic Transducers (Microphones)Frequency Response CharacteristicsDigital Audio File FormatsHeart Sound SensingLung Sound SensingSnore MeterSpectrogram (STFT)Ambient Sound AnalysisSound RecognitionRecognizing Asthma SoundPeak ShiftFeature CompressionRegroupingNoise IssuesFuture ApplicationsSummaryProblemsColor SensorsColor SensingHuman Color VisionColor SensorsColor Matching ExperimentsC...

  19. Coherent Synchrotron Radiation as a Diagnostic Tool for the LCLS Longitudinal Feedback System

    CERN Document Server

    Wu, Juhao; Huang, Zhirong

    2005-01-01

    The Linac Coherent Light Source (LCLS) will be the world's first x-ray free-electron laser (FEL). To ensure the vitality of FEL lasing, a longitudinal feedback system is required together with other diagnostics. In this paper, we study the possibility of using Coherent Synchrotron Radiation (CSR) from the chicane as the diagnostic tool for bunch length feedback. Calculations show that CSR is a good candidate, even for the non-Gaussian, double-horn longitudinal charge distribution. We further check the feasibility for low and high charge options, and also the possibility for detecting the microbunching.

  20. Screening and incorporation of rust resistance from Allium cepa into bunching onion (Allium fistulosum) via alien chromosome addition.

    Science.gov (United States)

    Wako, Tadayuki; Yamashita, Ken-ichiro; Tsukazaki, Hikaru; Ohara, Takayoshi; Kojima, Akio; Yaguchi, Shigenori; Shimazaki, Satoshi; Midorikawa, Naoko; Sakai, Takako; Yamauchi, Naoki; Shigyo, Masayoshi

    2015-04-01

    Bunching onion (Allium fistulosum L.; 2n = 16), bulb onion (Allium cepa L. Common onion group), and shallot (Allium cepa L. Aggregatum group) cultivars were inoculated with rust fungus, Puccinia allii, isolated from bunching onion. Bulb onions and shallots are highly resistant to rust, suggesting they would serve as useful resources for breeding rust resistant bunching onions. To identify the A. cepa chromosome(s) related to rust resistance, a complete set of eight A. fistulosum - shallot monosomic alien addition lines (MAALs) were inoculated with P. allii. At the seedling stage, FF+1A showed a high level of resistance in controlled-environment experiments, suggesting that the genes related to rust resistance could be located on shallot chromosome 1A. While MAAL, multi-chromosome addition line, and hypoallotriploid adult plants did not exhibit strong resistance to rust. In contrast to the high resistance of shallot, the addition line FF+1A+5A showed reproducibly high levels of rust resistance.

  1. Radiation of charged-particle bunches passing perpendicularly by the edge of a semi-infinite planar wire structure.

    Science.gov (United States)

    Tyukhtin, Andrey V; Vorobev, Viktor V; Galyamin, Sergey N

    2015-06-01

    The radiation of a charged-particle bunch moving perpendicularly to a semi-infinite plane grid composed of thin parallel wires is analyzed using the method of averaged boundary conditions (the period of the grid is assumed to be much less than the wavelengths under investigation). We perform an analysis of the volume radiation and surface waves generated by a bunch of finite length. It is shown that the patterns of the volume radiation fundamentally differ from those that arise in the case of an infinite grid. The properties of the surface waves are similar to the properties of Cherenkov radiation in a three-dimensional wire metamaterial. These waves propagate along the wires at the speed of light in a vacuum and do not diminish with distance (if absorption is negligible). The structure of the surface waves allows for the determination of the size and form of the particle bunches.

  2. Current-horn suppression for reduced coherent-synchrotron-radiation-induced emittance growth in strong bunch compression

    Science.gov (United States)

    Charles, T. K.; Paganin, D. M.; Latina, A.; Boland, M. J.; Dowd, R. T.

    2017-03-01

    Control of coherent synchrotron radiation (CSR)-induced emittance growth is essential in linear accelerators designed to deliver very high brightness electron beams. Extreme current values at the head and tail of the electron bunch, resulting from strong bunch compression, are responsible for large CSR production leading to significant transverse projected emittance growth. The Linac Coherent Light Source (LCLS) truncates the head and tail current spikes which greatly improves free electron laser (FEL) performance. Here we consider the underlying dynamics that lead to formation of current spikes (also referred to as current horns), which has been identified as caustics forming in electron trajectories. We present a method to analytically determine conditions required to avoid the caustic formation and therefore prevent the current spikes from forming. These required conditions can be easily met, without increasing the transverse slice emittance, through inclusion of an octupole magnet in the middle of a bunch compressor.

  3. Ion bunch stacking in a Penning trap after purification in an electrostatic mirror trap

    CERN Document Server

    Rosenbusch, M; Blaum, K; Borgmann, Ch; Kreim, S; Lunney, D; Manea, V; Schweikhard, L; Wienholtz, F; Wolf, R N

    2014-01-01

    The success of many measurements in analytical mass spectrometry as well as in precision mass determinations for atomic and nuclear physics is handicapped when the ion sources deliver ``contaminations'', i.e., unwanted ions of masses similar to those of the ions of interest. In particular, in ion-trapping devices, large amounts of contaminant ions result in significant systematic errors-if the measurements are possible at all. We present a solution for such cases: The ions from a quasi-continuous source are bunched in a linear radio-frequency-quadrupole ion trap, separated by a multi-reflection time-of-flight section followed by a Bradbury-Nielsen gate, and then captured in a Penning trap. Buffer-gas cooling is used to damp the ion motion in the latter, which allows a repeated opening of the Penning trap for a stacking of mass-selected ion bunches. Proof-of-principle demonstrations have been performed with the ISOLTRAP setup at ISOLDE/CERN, both with Cs-133(+) ions from an off-line ion source and by applicati...

  4. Use of high-boiling point organic solvents for pulping oil palm empty fruit bunches.

    Science.gov (United States)

    Rodríguez, Alejandro; Serrano, Luis; Moral, Ana; Pérez, Antonio; Jiménez, Luis

    2008-04-01

    Oil palm empty fruit bunches were used as an alternative raw material to obtain cellulosic pulp. Pulping was done by using high-boiling point organic solvents of decreased polluting power relative to classical (Kraft, sulphite) solvents but affording operation at similar pressure levels. The holocellulose, alpha-cellulose and lignin contents of oil palm empty fruit bunches (viz. 66.97%, 47.91% and 24.45%, respectively) are similar to those of some woody raw materials such as pine and eucalyptus, and various non-wood materials including olive tree prunings, wheat straw and sunflower stalks. Pulping tests were conducted by using ethyleneglycol, diethyleneglycol, ethanolamine and diethanolamine under two different sets of operating conditions, namely: (a) a 70% solvent concentration, 170 degrees C and 90 min; and (b) 80% solvent, 180 degrees C and 150 min. The solid/liquid ratio was six in both cases. The amine solvents were found to provide pulp with better properties than did the glycol solvents. Ethanolamine pulp exhibited the best viscosity and drainage index (viz. 636 mL/g and 17 degrees SR, respectively), and paper made from it the best breaking length (1709 m), stretch (1.95%), burst index (0.98 kN/g) and tear index (0.33 mNm(2)/g). Operating costs can be reduced by using milder conditions, which provide similar results. In any case, the amines are to be preferred to the glycols as solvents for this purpose.

  5. Production of furfural from palm oil empty fruit bunches: kinetic model comparation

    Science.gov (United States)

    Panjaitan, J. R. H.; Monica, S.; Gozan, M.

    2017-05-01

    Furfural is a chemical compound that can be applied to pharmaceuticals, cosmetics, resins and cleaning compound which can be produced by acid hydrolysis of biomass. Indonesia’s demand for furfural in 2010 reached 790 tons that still imported mostly 72% from China. In this study, reaction kinetic models of furfural production from oil palm empty fruit bunches with submitting acid catalyst at the beginning of the experiment will be determine. Kinetic data will be obtained from hydrolysis of empty oil palm bunches using sulfuric acid catalyst 3% at temperature 170°C, 180°C and 190°C for 20 minutes. From this study, the kinetic model to describe the production of furfural is the kinetic model where generally hydrolysis reaction with an acid catalyst in hemicellulose and furfural will produce the same decomposition product which is formic acid with different reaction pathways. The activation energy obtained for the formation of furfural, the formation of decomposition products from furfural and the formation of decomposition products from hemicellulose is 8.240 kJ/mol, 19.912 kJ/mol and -39.267 kJ / mol.

  6. A pulsed drift cavity to capture 30 keV ion bunches at ground potential

    CERN Document Server

    Coeck, S

    2007-01-01

    To capture radioactive ion beams of tens of keV in an ion trap, the use of a pulsed drift cavity allows one to avoid placing the complete setup on a high voltage (HV) platform. By pulsing down the voltage on a long electrode while the ion bunch is inside it, the electric potential zero level can be shifted down over a range equal to the initial beam energy, thus allowing the ions to be captured in a trap at ground potential. The pulsed drift cavity of the WITCH setup, which is completely HV-platform free, is described here. It is demonstrated that bunched beams with energies of typically 30–60 keV, as will become available to all users at the ISOLDE facility after the installation of an RFQ buncher, can be transported over distances of tens of meters to the experiments and by means of a pulsed drift cavity directly be injected into a purification Penning trap. Simulation work showing the efficiency of such a system is discussed and tests showing the feasibility of such a system are presented. An estimate of...

  7. Cold optical injection producing monoenergetic, multi-GeV electron bunches.

    Science.gov (United States)

    Davoine, X; Lefebvre, E; Rechatin, C; Faure, J; Malka, V

    2009-02-13

    A cold optical injection mechanism for a laser-plasma accelerator is described. It relies on a short, circularly polarized, low-energy laser pulse counterpropagating to and colliding with a circularly polarized main pulse in a low density plasma. Contrary to previously published optical injection schemes, injection is not caused here by electron heating. Instead, the collision between the pulses creates a spatially periodic and time-independent beat force. This force can block the longitudinal electron motion, leading to their entry and injection into the propagating wake. In a specific setup, we compute after acceleration over 0.6 mm, a 60 MeV, 50 pC electron bunch with 0.7 MeV rms energy spread, proving the interest of this scheme to inject electron bunches with a narrow absolute energy spread. Acceleration to 3 GeV with a rms spread smaller than 1% is computed after propagation over 3.8 cm in a plasma channel.

  8. Hydrothermal pre-treatment of oil palm empty fruit bunch into fermentable sugars

    Science.gov (United States)

    Muhd Ali, M. D.; Tamunaidu, P.; Nor Aslan, A. K. H.; Morad, N. A.; Sugiura, N.; Goto, M.; Zhang, Z.

    2016-06-01

    Presently oil palm empty fruit bunch (OPEFB) is one of the solid waste which is produced daily whereby it is usually left at plantation site to act as organic fertilizer for the plants to ensure the sustainability of fresh fruit bunch. The major drawback in biomass conversion technology is the difficulty of degrading the material in a short period of time. A pre-treatment step is required to break the lignocellulosic biomass to easily accessible carbon sources for further use in the production of fuels and fine chemicals. Therefore, this study investigated the effect of hydrothermal pre-treatment under different reaction temperatures (100 - 250°C), reaction time (10 - 40 min), solid to solvent ratio of (1:10 - 1:20 w/v) and particle size (0.15 - 1.00 mm) on the solubilization of OPEFB to produce soluble fermentable sugars. The maximum soluble sugars of 68.18 mg glucose per gram of OPEFB were achieved at 175°C of reaction temperature, 20 min of reaction time, 1:15 w/v of solid to solvent ratio for 30 mm of particle size. Results suggest that reaction temperature, reaction time, the amount of solid to solvent ratio and size of the particle are crucial parameters for hydrothermal pretreatment, in achieving a high yield of soluble fermentable sugars.

  9. Entangled de Sitter from stringy axionic Bell pair I: an analysis using Bunch-Davies vacuum

    Science.gov (United States)

    Choudhury, Sayantan; Panda, Sudhakar

    2018-01-01

    In this work, we study the quantum entanglement and compute entanglement entropy in de Sitter space for a bipartite quantum field theory driven by an axion originating from Type IIB string compactification on a Calabi-Yau three fold (CY^3) and in the presence of an NS5 brane. For this computation, we consider a spherical surface S^2, which divides the spatial slice of de Sitter (dS_4) into exterior and interior sub-regions. We also consider the initial choice of vacuum to be Bunch-Davies state. First we derive the solution of the wave function of the axion in a hyperbolic open chart by constructing a suitable basis for Bunch-Davies vacuum state using Bogoliubov transformation. We then derive the expression for density matrix by tracing over the exterior region. This allows us to compute the entanglement entropy and Rényi entropy in 3+1 dimension. Furthermore, we quantify the UV-finite contribution of the entanglement entropy which contain the physics of long range quantum correlations of our expanding universe. Finally, our analysis complements the necessary condition for generating non-vanishing entanglement entropy in primordial cosmology due to the axion.

  10. Anisotropic graphene growth accompanied by step bunching on a dynamic copper surface.

    Science.gov (United States)

    Hayashi, Kenjiro; Sato, Shintaro; Yokoyama, Naoki

    2013-01-18

    We investigated the initial stage of chemical vapor deposition graphene growth on Cu film at low pressure, where Cu evaporation intensively occurs. Surface steps on the Cu surface were found to be the nucleation sites of graphene islands and to affect the subsequent growth. For the first time, we observed anisotropic graphene growth on the Cu surface accompanied by morphological changes, resulting in an arrayed graphene ribbon formation. The resultant surface morphology is attributed to step bunching during growth. Detailed analyses suggest that the graphene arrays, which were preferentially formed along the steps, served as partial shields of the Cu surface, preventing step-flow-like Cu atom diffusion and evaporation at the growth site. As a result, the growth locations acted as a pinning site of the step motion, leading to step bunching. Such selective growth by using surface morphology has the potential to control not only the nucleation site but also the geometry of graphene for tailoring graphene-based nanomaterials such as nanoribbons and quantum dots.

  11. The beam bunching and transport system of the Argonne positive ion injector

    Energy Technology Data Exchange (ETDEWEB)

    Den Hartog, P.K.; Bogaty, J.M.; Bollinger, L.M.; Clifft, B.E.; Pardo, R.C.; Shepard, K.W.

    1989-01-01

    A new positive ion injector (PII) is currently under construction at Argonne that will replace the existing 9-MV tandem electrostatic accelerator as an injector into ATLAS. It consists of an electron-cyclotron resonance-ion source on a 350-kV platform injecting into a superconducting linac optimized for very slow (..beta.. less than or equal to .007 c) ions. This combination can potentially produce even higher quality heavy-ion beams than are currently available from the tandem since the emittance growth within the linac is largely determined by the quality of the bunching and beam transport. The system we have implemented uses a two-stage bunching system, composed of a 4-harmonic gridded buncher located on the ECR high-voltage platform and a room temperature spiral-loaded buncher of novel design. A sinusoidal beam chopper is used for removal of tails. The beam transport is designed to provide mass resolution of M/..delta..M > 250 and a doubly-isochronous beamline is used to minimize time spread due to path length differences. 4 refs., 2 figs.

  12. On the Production of Flat Electron Bunches for Laser Wake Field Acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Kando, M.; Fukuda, Y.; Kotaki, H.; Koga, J.; Bulanov, S.V.; Tajima, T.; /JAERI, Kyoto; Chao, A.; Pitthan, R.; /SLAC; Schuler, K.-P.; /DESY; Zhidkov, A.G.; /CRIEPI, Tokyo; Nemoto, K.; /CRIEPI, Tokyo

    2006-06-27

    We suggest a novel method for injection of electrons into the acceleration phase of particle accelerators, producing low emittance beams appropriate even for the demanding high energy Linear Collider specifications. In this paper we work out the injection into the acceleration phase of the wake field in a plasma behind a high intensity laser pulse, taking advantage of the laser polarization and focusing. With the aid of catastrophe theory we categorize the injection dynamics. The scheme uses the structurally stable regime of transverse wake wave breaking, when electron trajectory self-intersection leads to the formation of a flat electron bunch. As shown in three-dimensional particle-in-cell simulations of the interaction of a laser pulse in a line-focus with an underdense plasma, the electrons, injected via the transverse wake wave breaking and accelerated by the wake wave, perform betatron oscillations with different amplitudes and frequencies along the two transverse coordinates. The polarization and focusing geometry lead to a way to produce relativistic electron bunches with asymmetric emittance (flat beam). An approach for generating flat laser accelerated ion beams is briefly discussed.

  13. Suppression of Beam-Ion Instability in Electron Rings with Multi-Bunch Train Beam Fillings

    Energy Technology Data Exchange (ETDEWEB)

    Wang, L.; Cai, Y.; Raubenheimer, T.O.; /SLAC; Fukuma, H.; /KEK, Tsukuba

    2011-08-18

    The ion-caused beam instability in the future light sources and electron damping rings can be serious due to the high beam current and ultra-small emittance of picometer level. One simple and effective mitigation of the instability is a multi-bunch train beam filling pattern which can significantly reduce the ion density near the beam, and therefore reduce the instability growth rate up to two orders of magnitude. The suppression is more effective for high intensity beams with low emittance. The distribution and the field of trapped ions are benchmarked to validate the model used in the paper. The wake field of ion-cloud and the beam-ion instability is investigated both analytically and numerically. We derived a simple formula for the build-up of ion-cloud and instability growth rate with the multi-bunch-train filling pattern. The ion instabilities in ILC damping ring, SuperKEKB and SPEAR3 are used to compare with our analyses. The analyses in this paper agree well with simulations.

  14. Splittings, coalescence, bunch and snake patterns in the 3D nonlinear Schrödinger equation with anisotropic dispersion

    DEFF Research Database (Denmark)

    Germaschewski, K.; Grauer, R.; Bergé, L.

    2001-01-01

    are detailed and compared with those characterizing collapsing objects with no anisotropic dispersion. Their ability to mutually coalesce is also analyzed and modeled from the interaction of Gaussian components. Next, bunch-type and snake-type instabilities, which result from periodic modulations driven...... by even and odd localized modes, are studied. The influence of the initial wave amplitude, the amplitude and wavenumber of the perturbations on the interplay of snake and bunch patterns are finally discussed. (C) 2001 Elsevier Science B.V. All rights reserved....

  15. The Computer Code NOVO for the Calculation of Wake Potentials of the Very Short Ultra-relativistic Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Novokhatski, Alexander; /SLAC

    2005-12-01

    The problem of electromagnetic interaction of a beam and accelerator elements is very important for linear colliders, electron-positron factories, and free electron lasers. Precise calculation of wake fields is required for beam dynamics study in these machines. We describe a method which allows computation of wake fields of the very short bunches. Computer code NOVO was developed based on this method. This method is free of unphysical solutions like ''self-acceleration'' of a bunch head, which is common to well known wake field codes. Code NOVO was used for the wake fields study for many accelerator projects all over the world.

  16. Architecture and technology of 500 Msample/s feedback systems for control of coupled-bunch instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Teytelman, Dmitry

    2000-03-30

    Feedback control of coupled-bunch instabilities presents many challenges. Control bandwidths up to 250 MHz are required to damp all of the unstable coupled-bunch modes in recent accelerators. A digital parallel-processing array with 80 DSPs has been developed to control longitudinal instabilities in PEP-II/ALS/DA NE machines. Here the authors present a description of the architecture as well as the technologies used to implement 500 Msample/s real-time control system with 2,000 FIR filtering channels. Algorithms for feedback control, data acquisition, and analysis are described and measurements from ALS are presented.

  17. Detector Performance and Upgrade Plans of the Pixel Luminosity Telescope for Online per-Bunch Luminosity Measurement at CMS

    CERN Document Server

    CMS Collaboration

    2017-01-01

    The Pixel Luminosity Telescope (PLT) is a dedicated system for luminosity measurement at the CMS experiment using silicon pixel sensors. It was installed during LS1 and has been providing luminosity measurements throughout Run 2. The online bunch-by-bunch luminosity measurement employs the "fast-or" capability of the pixel readout chip (PSI46) to quickly identify likely tracks at the full 40MHz interaction rate. In addition, the full pixel information is read out at a lower rate, allowing for more detailed offline analysis. In this talk, we will present details of the commissioning, performance and operational history of the currently installed hardware and upgrade plans for LS2.

  18. Simulation Results of a Feedback Control System to Damp Electron Cloud Single-Bunch Transverse Instabilities In The Cern SPS

    Energy Technology Data Exchange (ETDEWEB)

    Secondo, R.; Vay, J. L.; Venturini, M.; Fox, J. D.; Rivetta, C. H.; Hofle, W.

    2011-03-28

    Transverse Single-Bunch Instabilities due to the Electron Cloud effect are limiting the operation at high current of the SPS at CERN. Recently a high-bandwidth Feedback System has been proposed as a possible solution to stabilize the beam and is currently under study. We analyze the dynamics of the bunch actively damped with a simple model of the Feedback in the macro-particle code WARP, in order to investigate the limitations of the System such as the minimum amount of power required to maintain stability. We discuss the feedback model, report on simulation results and present our plans for further development of the numerical model.

  19. Different miRNA expression profiles between human breast cancer turmors and serum

    Directory of Open Access Journals (Sweden)

    Jie eZhu

    2014-05-01

    Full Text Available A bunch of miRNAs have been demonstrated to be aberrantly expressed in cancer tumor tissue and serum. The miRNA signatures identified from the serum samples could serve as potential noninvasive diagnostic markers for breast cancer. The role of the miRNAs in cancerigenesis is unclear. In this study, we generated the expression profiles of miRNAs from the paired breast cancer tumors, normal, tissue, and serum samples from eight patients using small RNA-sequencing. Serum samples from eight healthy individuals were used as normal controls. We identified total 174 significantly differentially expressed miRNAs between tumors and the normal tissues, and 109 miRNAs between serum from patients and serum from healthy individuals. There are only 10 common miRNAs. This suggests that only a small portion of tumor miRNAs are released into serum selectively. Interestingly, the expression change pattern of 28 miRNAs is opposite between breast cancer tumors and serum. Functional analysis shows that the differentially expressed miRNAs and their target genes form a complex interaction network affecting many biological processes and involving in many types of cancer such as prostate cancer, basal cell carcinoma, acute myeloid leukemia, and more.

  20. Glaucoma diagnostics.

    Science.gov (United States)

    Geimer, Sabina Andersson

    2013-02-01

    This thesis addresses several aspects of glaucoma diagnostics from both a clinical and a screening perspective. New instruments for diagnosing glaucoma have been developed over the past years, but little information is available regarding their performance as screening methods and their usefulness in ordinary clinical practice. PURPOSE OF THE RESEARCH UNDERLYING THIS THESIS:  The objectives of this research were as follows: to compare the accuracy of results of analysis of the optic nerve head (ONH) achieved by computerized imaging using the Heidelberg Retina Tomograph (HRT) and by subjective assessment performed by physicians with different degrees of experience of glaucoma (paper III); to evaluate the effect of a continuous medical education (CME) lecture on subjective assessment of the ONH for diagnosis of glaucoma (paper II); to investigate subjective assessment of perimetric test results by physicians with varying knowledge of glaucoma with a trained artificial neural network (ANN) and to compare the certainty of the classifications (paper IV); and to compare the diagnostic performance of time-domain Stratus optical coherence tomography (OCT) with that of spectral-domain Cirrus OCT (paper I), frequency doubling technology (FDT) screening perimetry and scanning laser polarimetry with the GDx variable corneal compensator (VCC) in a random population-based sample and in patients with glaucoma of varying disease severity.   In evaluation of the ONH, use of the HRT statistical tools, Moorfields regression analysis (MRA) and the Glaucoma Probability Score (GPS) was compared with subjective assessment performed by 45 physicians. Optic nerve head images and photographs from 138 healthy and 97 glaucoma subjects were included. The sensitivity of MRA was higher (87-94%) than that of the average physician (62-82%), considerably greater than that of ophthalmologists with subspecialties other than glaucoma (53-77%) and non-significantly better than that of glaucoma