WorldWideScience

Sample records for building exits

  1. Architecture design of Exit-Entry Administration Building of Shanghai Municipal Public Security Bureau

    Institute of Scientific and Technical Information of China (English)

    JIANG Limin; JIANG Du

    2007-01-01

    In retrospect of the architecture design of Exit- Entry Administration Building of Shanghai Municipal Public Security Bureau, this paper elaborates on the architect's pursuit of the symbol of the image, the fluidity of the space and the sequence of the function. It promotes a case which deals with the harmony of the architecture individuality and the urban space commonness in city center.

  2. Build to order and entry/exit strategies under exchange rate uncertainty

    Directory of Open Access Journals (Sweden)

    Lin Chin-Tsai

    2004-01-01

    Full Text Available Under uncertainty of exchange rate, we extend the build to order production model of Lin et al. (2002 by considering the export-oriented manufacturer to make decisions to switch production location freely between domestic and foreign ones. The export-oriented manufacturer is risk neutral and has rational expectations. When we transfer the production location from domestic (foreign to foreign (domestic, and the production location transferring cost and the drift of real exchange rate are both equal to zero, then the optimal entry and exit threshold value of Cobb-Douglas production function are equal, no matter whether we use real options or net present value method. Thus export-oriented manufacturer can make decisions at the optimal transfer threshold value for transferable locations wherever the production locations are. It provides the export-oriented manufacturer with another way of thinking.

  3. 既有建筑拆除物再生利用研究综述%Recycling Research of Exiting Building Demolition Material

    Institute of Scientific and Technical Information of China (English)

    童滋捷; 宗兰; 张士萍

    2012-01-01

    Through analysis and research on a large number of domestic literature about the exiting building demolition material recycling, this article analyzes the background of the development of domestic exiting building demolition material recycling and basic characteristics of the removal material recychng. Side by side, contrarily the analysis of treatment and utilization of the current situation, it points out comprehensive utiliza- tion of possibilities and feasibility of exiting building demolition material.%文章通过对国内大量既有建筑拆除物再生利用文献的分析与研究,分析了我国既有建筑拆除物再生利用发展的背景以及拆除剩余物再生利用的基本特点。并针对目前处理利用的现状进行了分析,提出了对既有建筑拆除物综合利用的可能性和可行性。

  4. Exit from contract

    Directory of Open Access Journals (Sweden)

    Oren Bar-Gill

    2016-01-01

    Full Text Available Objective to study the procedure of exiting the contract its costs and benefits. Methods statistical method comparative analysis. Results free exit from contract is one of the most powerful tools for the consumer rights protection. The procedure frees consumers from bad deals and keeps businesses honest. Yet consumers often choose transactions with lockin provisions trading off exit rights for other perks. This article examines the costs and benefits of free exit as compared to the lockin alternative. According to the authors the present regulation of exit penalties in the USA is poorly tailored to address concerns about lockin particularly in light of increasingly ubiquitous marketbased solutions. The article also calls regulatory attention to loyalty rewards which are shown to be as powerful as exit penalties and equally detrimental. Scientific novelty the article reveals a paradoxical state of the law exit regulations in the USA are used most where they are needed least. Termination penalties present an obvishyous target for regulatory intervention while loyalty programs seem benign not warranting any regulatory attention. Practical significance the article is of interest for the Russian juridical science and lawmaking authorities as in Russia the issue of exiting the contract is as topical as in the USA and requires solution which would impair neither the rights of consumers nor the rights of the sellers ofnbspproducts and services. nbsp

  5. Exit-strategies

    DEFF Research Database (Denmark)

    Mørck, Line Lerche; Palm, Anne-Mette; Sys Møller-Andersen, Camilla

    This paper is about exit-strategies, constructing a theoretical and empirical informed analysis of current societal conditions that influence motor cycle gangs such as Hells Angels or Bandidos and other ‘wild' youth' possibilities and limitations for moving beyond criminal activities. We especially...... focus on the involved communities in the current Danish gang-conflict, which escalated with deadly killings in 2008, and thereby became a so called "gang-war". We will start out presenting different practice notions of exit, and we will extend and discuss understandings of "exit-strategies" by analyzing...... different empirical sources. To develop and extend an "exit-prototype" about conditions of importance for moving beyond a gang/criminal position, we have analyzed documents (from newspapers and books), involved ex-gang members, social workers and experts as co-researchers in interviews, "gang...

  6. 既有建筑拆除物碎砖类骨料再生混凝土的可行性研究%Feasibility Study of the Exiting Building Demolition Material the Brickbat Class Aggregate of Recycled Concrete

    Institute of Scientific and Technical Information of China (English)

    童滋捷; 宗兰; 张士萍

    2012-01-01

    By using the exiting buildings to remove material broken bricks as aggregate , this article describes the background and purpose of preparation of recycled concrete. And, it has done a feasibility study about preparation of recycled concrete contents , steps, technologies routes and so on .%文章介绍了利用既有建筑拆除物碎砖作为骨料,制备再生混凝土的研究背景及目的,并对既有建筑拆除物中的碎砖作为骨料.制备再生混凝土的研究内容、步骤、技术路线等方面做了可行性研究。

  7. Exit and Voice: Organizational Loyalty and Dispute Resolution Strategies

    Science.gov (United States)

    Hoffmann, Elizabeth A.

    2006-01-01

    This study compares workplace dispute resolution strategies (exit, voice and toleration) in matched pairs of conventional and worker-owned cooperative organizations operating in three industries--coal mining, taxicab driving and organic food distribution. Building on Hirschman's classic exit, voice and loyalty thesis, this research demonstrates…

  8. Exit from Synchrony in Joint Improvised Motion

    Science.gov (United States)

    Dahan, Assi; Noy, Lior; Hart, Yuval; Mayo, Avi; Alon, Uri

    2016-01-01

    Motion synchrony correlates with effective and well-rated human interaction. However, people do not remain locked in synchrony; Instead, they repeatedly enter and exit synchrony. In many important interactions, such as therapy, marriage and parent-infant communication, it is the ability to exit and then re-enter synchrony that is thought to build strong relationship. The phenomenon of entry into zero-phase synchrony is well-studied experimentally and in terms of mathematical modeling. In contrast, exit-from-synchrony is under-studied. Here, we focus on human motion coordination, and examine the exit-from-synchrony phenomenon using experimental data from the mirror game paradigm, in which people perform joint improvised motion, and from human tracking of computer-generated stimuli. We present a mathematical mechanism that captures aspects of exit-from-synchrony in human motion. The mechanism adds a random motion component when the accumulated velocity error between the players is small. We introduce this mechanism to several models for human coordinated motion, including the widely studied HKB model, and the predictor-corrector model of Noy, Dekel and Alon. In all models, the new mechanism produces realistic simulated behavior when compared to experimental data from the mirror game and from tracking of computer generated stimuli, including repeated entry and exit from zero-phase synchrony that generates a complexity of motion similar to that of human players. We hope that these results can inform future research on exit-from-synchrony, to better understand the dynamics of coordinated action of people and to enhance human-computer and human-robot interaction. PMID:27711185

  9. Exit Polls and Voter Turnout

    DEFF Research Database (Denmark)

    Andersen, Asger Lau; Jensen, Thomas

    2014-01-01

    After the 2009 referendum on a proposed change to the Danish Law of Succession, it was widely claimed that the early publication of exit poll results changed the rate of turnout and eventually the outcome. We investigate this claim and contribute to the wider debate on the implications of exit...... polls by setting up and analyzing a formal model. We find that the introduction of an exit poll influences the incentive to vote both before and after the poll is published, but the signs of the effects are generally ambiguous. The observation that exit polls influence the incentive to vote even before...... they are published is often overlooked. We show that this can lead to premature conclusions about the impact of exit polls on electoral outcomes. In particular, in cases such as the Danish referendum where it clearly appears that exit polls changed the outcome, it could well be that the outcome would...

  10. Promoting Exit from Violent Extremism

    DEFF Research Database (Denmark)

    Dalgaard-Nielsen, Anja

    2013-01-01

    A number of Western countries are currently adding exit programs targeting militant Islamists to their counterterrorism efforts. Drawing on research into voluntary exit from violent extremism, this article identifies themes and issues that seem to cause doubt, leading to exit. It then provides...... a perspective on how these natural sources of doubt might best be brought to bear in connection with an exit program by drawing on social psychology and research into persuasion and attitude change. It is argued that an external intervention should stay close to the potential exiter’s own doubt, make...

  11. Exit Polls and Voter Turnout

    DEFF Research Database (Denmark)

    Andersen, Asger Lau; Jensen, Thomas

    We set up a model of elections or referendums with two alternatives to study how voter turnout and election outcomes are affected by the publication of exit polls on election day. We find that the introduction of an exit poll influences the incentive to vote both before and after the poll is...... published, but the signs of the effects are generally ambiguous. The fact that exit polls influence the incentive to vote before they are even published is sometimes overlooked in the debate on their desirability. We show that this can lead to premature conclusions about the impact of exit polls on election...

  12. Exiting prostitution: an integrated model.

    Science.gov (United States)

    Baker, Lynda M; Dalla, Rochelle L; Williamson, Celia

    2010-05-01

    Exiting street-level prostitution is a complex, convoluted process. Few studies have described this process within any formal conceptual framework. This article reviews two general models and two prostitution-specific models and their applicability to the exiting process. Barriers encountered as women attempt to leave the streets are identified. Based on the four models, the barriers, the prostitution literature, and the authors' experience with prostituted women, a new integrated six-stage model that is comprehensive in scope and sensitive to women's attempts to exit prostitution is offered as a foundation for continued research on the process of women leaving the streets.

  13. Exit EI Jefe

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Fidel Castro has left the political stage after nearly 50 years as Cuba’s president Fidel Castro’s resignation inevitably has become the focus of the international community.Cubans have made significant achieve- ments in building socialism under the leadership of Castro. International affairs observers are curious to see what will become of Cuba without Fidel Castro. Where will Cuba go? When Castro fell ill and was hospitalized in August 2006, experts started discussing and

  14. Computing the Exit Complexity of Knowledge in Distributed Quantum Computers

    Directory of Open Access Journals (Sweden)

    M.A.Abbas

    2013-01-01

    Full Text Available Distributed Quantum computers abide from the exit complexity of the knowledge. The exit complexity is the accrue of the nodal information needed to clarify the total egress system with deference to a distinguished exit node. The core objective of this paper is to compile an arrogant methodology for assessing the exit complexity of the knowledge in distributed quantum computers. The proposed methodology is based on contouring the knowledge using the unlabeled binary trees, hence building an benchmarked and a computer based model. The proposed methodology dramatizes knowledge autocratically calculates the exit complexity. The methodology consists of several amphitheaters, starting with detecting the baron aspect of the tree of others entitled express knowledge and then measure the volume of information and the complexity of behavior destining from the bargain of information. Then calculate egress resulting from episodes that do not lead to the withdrawal of the information. In the end is calculated total egress complexity and then appraised total exit complexity of the system. Given the complexity of the operations within the Distributed Computing Quantity, this research addresses effective transactions that could affect the three-dimensional behavior of knowledge. The results materialized that the best affair where total exit complexity as minimal as possible is a picture of a binary tree is entitled at the rate of positive and negative cardinal points medium value. It could be argued that these cardinal points should not amass the upper bound apex or minimum.

  15. Intelligent Exit-Selection Behaviors during a Room Evacuation

    Institute of Scientific and Technical Information of China (English)

    Zarita Zainuddin; Lim Eng Aik

    2012-01-01

    A modified version of the existing cellular automata (CA) model is proposed to simulate an evacuation procedure in a classroom with and without obstacles. Based on the numerous literature on the implementation of CA in modeling evacuation motions, it is notable that most of the published studies do not take into account the pedestrian's ability to select the exit route in their models. To resolve these issues, we develop a CA model incorporating a probabilistic neural network for determining the decision-making ability of the pedestrians, and simulate an exit-selection phenomenon in the simulation. Intelligent exit-selection behavior is observed in our model. From the simulation results, it is observed that occupants tend to select the exit closest to them when the density is low, but if the density is high they will go to an aiternative exit so as to avoid a long wait. This reflects the fact that occupants may not fully utilize multiple exits during evacuation. The improvement in our proposed model is valuable for further study and for upgrading the safety aspects of building designs.%A modified version of the existing cellular automata (CA) model is proposed to simulate an evacuation procedure in a classroom with and without obstacles.Based on the numerous literature on the implementation of CA in modeling evacuation motions,it is notable that most of the published studies do not take into account the pedestrian's ability to select the exit route in their models.To resolve these issues,we develop a CA model incorporating a probabilistic neural network for determining the decision-making ability of the pedestrians,and simulate an exit-selection phenomenon in the simulation.Intelligent exit-selection behavior is observed in our model.From the simulation results,it is observed that occupants tend to select the exit closest to them when the density is low,but if the density is high they will go to an alternative exit so as to avoid a long wait.This reflects the fact

  16. Exiting Poverty: Does Sex Matter?

    OpenAIRE

    Lori J. Curtis; Kathleen Rybczynski

    2013-01-01

    While Murphy, Zhang & Dionne (2012) report a slight decrease in the average duration of poverty spells in Canada over the past decade, little is understood about the factors associated with poverty duration in Canada, nor which factors, if any, may affect women and men differently. Moreover, research pays scant attention to how far Canadians transition out of poverty. For example, some may exit poverty only marginally while others exit to much higher incomes. We investigate the determinants o...

  17. Early exit: Estimating and explaining early exit from drug treatment

    Directory of Open Access Journals (Sweden)

    Sanders Melony

    2008-04-01

    Full Text Available Abstract Background Early exit (drop-out from drug treatment can mean that drug users do not derive the full benefits that treatment potentially offers. Additionally, it may mean that scarce treatment resources are used inefficiently. Understanding the factors that lead to early exit from treatment should enable services to operate more effectively and better reduce drug related harm. To date, few studies have focused on drop-out during the initial, engagement phase of treatment. This paper describes a mixed method study of early exit from English drug treatment services. Methods Quantitative data (n = 2,624 was derived from three English drug action team areas; two metropolitan and one provincial. Hierarchical linear modelling (HLM was used to investigate predictors of early-exit while controlling for differences between agencies. Qualitative interviews were conducted with 53 ex-clients and 16 members of staff from 10 agencies in these areas to explore their perspectives on early exit, its determinants and, how services could be improved. Results Almost a quarter of the quantitative sample (24.5% dropped out between assessment and 30 days in treatment. Predictors of early exit were: being younger; being homeless; and not being a current injector. Age and injection status were both consistently associated with exit between assessment and treatment entry. Those who were not in substitution treatment were significantly more likely to leave treatment at this stage. There were substantial variations between agencies, which point to the importance of system factors. Qualitative analysis identified several potential ways to improve services. Perceived problems included: opening hours; the service setting; under-utilisation of motivational enhancement techniques; lack of clarity about expectations; lengthy, repetitive assessment procedures; constrained treatment choices; low initial dosing of opioid substitution treatment; and the routine requirement

  18. PCR, exit stage left ...

    CERN Multimedia

    2004-01-01

    The Prevessin Control Room during LEP's start up in 1989. The Prévessin Control Room (PCR) was recently engulfed in a wave of nostalgia. The PCR, scene of some of the greatest moments in CERN's history, is being dismantled to prepare for a complete overhaul. In February 2006, a new combined control centre for all the accelerators will open its doors on the same site, together with a new building currently under construction (see Bulletin issue 27/2004 of 28 June 2004). This marks the end of an important chapter in CERN's history. The Prévessin Control Room saw its first momentous event 28 years ago when the 400 GeV beam for the SPS was commissioned in the presence of Project Leader John Adams. It was also here that the first proton-antiproton collisions were observed, in 1981. Eight years later, in 1989, operators and directors alike jumped for joy at the announcement of the first electron-positron collisions at the start up of LEP, the biggest accelerator in the world. Today the 80 terminals and PCs have b...

  19. Bed-exit alarm effectiveness

    Science.gov (United States)

    Capezuti, Elizabeth; Brush, Barbara L.; Lane, Stephen; Rabinowitz, Hannah U.; Secic, Michelle

    2009-01-01

    This study describes the accuracy of two types of bed-exit alarms to detect bed-exiting body movements: pressure-sensitive and a pressure sensitive combined with infrared beam detectors (dual sensor system). We also evaluated the occurrence of nuisance alarms, or alarms that are activated when a participant does not attempt to get out of bed. Fourteen nursing home residents were directly observed for a total of 256 nights or 1,636.5 hours; an average of 18.3 ± 22.3 (± S.D.) nights/participant for an average of 6.4 ± 1.2 hours/night. After adjusting for body movements via repeated measures, Poisson regression modeling, the least squares adjusted means show a marginally significant difference between the type of alarm groups on the number of true positives (mean/S.E.M. = 0.086/1.617) for pressure-sensitive vs. dual sensor alarm (0.593/1.238; p = 0.0599) indicating that the dual sensor alarm may have a higher number of true positives. While the dual sensor bed-exit alarm was more accurate than the pressure sensitive alarm in identifying bed-exiting body movements and reducing the incidence of false alarms, false alarms were not eliminated altogether. Alarms are not a substitute for staff; adequate staff availability is still necessary when residents need or wish to exit bed. PMID:18508138

  20. First Degree Pacemaker Exit Block

    Directory of Open Access Journals (Sweden)

    Johnson Francis

    2016-10-01

    Full Text Available Usually atrial and ventricular depolarizations follow soon after the pacemaker stimulus (spike on the ECG. But there can be an exit block due to fibrosis at the electrode - tissue interface at the lead tip. This can increase the delay between the spike and atrial or ventricular depolarization.

  1. Technological Progress, Exit and Trade

    DEFF Research Database (Denmark)

    Schröder, Philipp; Sørensen, Allan

    productivity exporters are more likely to continue to export, and market exit is typically preceded by periods of contracting market shares. We show that the simple inclusion of exogenous economy wide technological progress into the standard Melitz (2003) model generates a tractable dynamic framework...

  2. 14 CFR 135.129 - Exit seating.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Exit seating. 135.129 Section 135.129....129 Exit seating. (a)(1) Applicability. This section applies to all certificate holders operating... certificate holder shall make the passenger exit seating determinations required by this paragraph in a...

  3. Exit From the High Street

    DEFF Research Database (Denmark)

    Bly, Sarah; Gwozdz, Wencke; Reisch, Lucia

    2015-01-01

    by focusing on a previously under-researched group of consumers – ‘sustainable fashion consumption pioneers’ who actively engage and shape their own discourse around the notion of sustainable fashion consumption. These pioneers actively create and communicate strategies for sustainable fashion behaviour...... that can overcome the nebulous and somewhat paradoxical reality that sustainable development in the fashion industry presents. Specifically, we use passive netnography and semi-structured interviews to illuminate the role of motivational and contextual factors that help shape these consumers' definitions...... of sustainable fashion including such key behaviours as purchasing fewer garments of higher quality, exiting the retail market, purchasing only second-hand fashion goods and sewing or upgrading their own clothing. Central to much of these behaviours is the notion that personal style, rather than fashion, can...

  4. Minimal Exit Trajectories with Optimum Correctional Manoeuvres

    Directory of Open Access Journals (Sweden)

    T. N. Srivastava

    1980-10-01

    Full Text Available Minimal exit trajectories with optimum correctional manoeuvers to a rocket between two coplaner, noncoaxial elliptic orbits in an inverse square gravitational field have been investigated. Case of trajectories with no correctional manoeuvres has been analysed. In the end minimal exit trajectories through specified orbital terminals are discussed and problem of ref. (2 is derived as a particular case.

  5. Beautiful Exit: Break Up With A Smile

    OpenAIRE

    Alajoutsijärvi, K; MÖller, K.; Tähtinen, J. (Jaana)

    1999-01-01

    This paper constructs a framework describing communication strategies available in dissolving interorganisational buyer-seller relationships. In particular, we bring in a quality aspect, as we are looking for strategies that could be labelled "beautiful exits". A beautiful exit is achieved by using a communication strategy that minimises damages occurring to the disengager, the other party and the connected network.

  6. Firm Exit, Technological Progress and Trade

    DEFF Research Database (Denmark)

    Schröder, Philipp; Sørensen, Allan

    The dynamics of export market exit and firm closure have found limited attention in the new heterogeneous-firms trade literature. In fact, several of the predictions on firm survival and exit stemming from this new class of models are at odds with the stylized facts. Empirically, higher...

  7. Exit strategies for social venture entrepreneurs

    NARCIS (Netherlands)

    Nuer, A.T.K.

    2015-01-01

    Key Words:  Social Venture Entrepreneurs, Exit, Ownership Social Venture Entrepreneurs invest in local and mostly bottom of pyramid (BoPs), and more so in developing economies. Different understanding  and meanings given to the term  exit and ownership, by social venture entrepreneurs

  8. Topological inflation with graceful exit

    Science.gov (United States)

    Marunović, Anja; Prokopec, Tomislav

    2016-04-01

    We investigate a class of models of topological inflation in which a super-Hubble-sized global monopole seeds inflation. These models are attractive since inflation starts from rather generic initial conditions, but their not so attractive feature is that, unless symmetry is again restored, inflation never ends. In this work we show that, in presence of another nonminimally coupled scalar field, that is both quadratically and quartically coupled to the Ricci scalar, inflation naturally ends, representing an elegant solution to the graceful exit problem of topological inflation. While the monopole core grows during inflation, the growth stops after inflation, such that the monopole eventually enters the Hubble radius, and shrinks to its Minkowski space size, rendering it immaterial for the subsequent Universe's dynamics. Furthermore, we find that our model can produce cosmological perturbations that source CMB temperature fluctuations and seed large scale structure statistically consistent (within one standard deviation) with all available data. In particular, for small and (in our convention) negative nonminimal couplings, the scalar spectral index can be as large as ns simeq 0.955, which is about one standard deviation lower than the central value quoted by the most recent Planck Collaboration.

  9. Room evacuation through two contiguous exits

    CERN Document Server

    Sticco, I M; Dorso, C O

    2016-01-01

    Current regulations demand that at least two exits should be available for a safe evacuation during a panic situation. Although the "faster is slower" effect is expected to take place near the exits, the evacuation time will improve because of the additional exits. However, rooms having contiguous doors not always reduce the leaving time as expected. We investigated the relation between the doors separation and the evacuation performance. We found that there exists a separation distance range that does not really improve the evacuation time, or it can even worsen the process performance. To our knowledge, no attention has been given to this issue in the literature. This work reports how the pedestrians dynamics differ when the separation distance between two exit doors changes and how this affects the overall performance.

  10. Entry and exit decisions under uncertainty

    DEFF Research Database (Denmark)

    Kongsted, Hans Christian

    1996-01-01

    This paper establishes the general deterministic limit that corresponds to Dixit's model of entry and exit decisions under uncertainty. The interlinked nature of decisions is shown to be essential also in the deterministic limit. A numerical example illustrates the result......This paper establishes the general deterministic limit that corresponds to Dixit's model of entry and exit decisions under uncertainty. The interlinked nature of decisions is shown to be essential also in the deterministic limit. A numerical example illustrates the result...

  11. Please use the emergency exit

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    In order to minimise the consequences of an incident like the one that occurred in 2008, the LHC has been fitted with safety valves. A total of 1,344 of these valves, whose function is to release the helium in the event of over-pressure, will be in place by the end of LS1.   The cutting operation is carried out using a circular saw designed at CERN. This photo was taken in Building 181 during training. Let's go back five years. It’s 2008 and an electrical incident has just caused a helium leak in LHC Sector 3-4. 30-tonne magnets moved half a metre as a result of the over-pressure. What did the ensuing investigation find? A defective electrical connection between two magnets caused a short-circuit, provoking an electrical arc, which in turn led to a leakage of liquid helium into the insulation vacuum of the cryostats containing the magnet cold masses. While helium is liquid at a temperature of 1.9 K (inside the magnets), it becomes gaseous as soon as the temperature exceeds 4...

  12. An Entrance to Exit Polling: Strategies for Using Exit Polls as Experiential Learning Projects

    Science.gov (United States)

    Berry, Michael J.; Robinson, Tony

    2012-01-01

    Engaging students in the design, administration, and postelection analysis of an exit poll can be an excellent experiential learning activity. Lelieveldt and Rossen (2009) argue that exit polls are a "perfect teaching tool" because they provide students with a cooperative (rather than competitive) learning experience; help students better connect…

  13. 12 CFR 611.1250 - Preliminary exit fee estimate.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Preliminary exit fee estimate. 611.1250 Section... System Institution Status § 611.1250 Preliminary exit fee estimate. (a) Preliminary exit fee estimate—terminating association. You must provide a preliminary exit fee estimate to us when you submit the plan...

  14. Exit strategies following percutaneous nephrolithotomy (PCNL)

    DEFF Research Database (Denmark)

    Cormio, Luigi; Gonzalez, Gaspar Ibarlucea; Tolley, David;

    2013-01-01

    PURPOSE: To compare the characteristics and outcomes of exit strategies following percutaneous nephrolithotomy (PCNL) using the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study database. MATERIALS AND METHODS: Two matched data sets were prepared in order to compare...... was associated with significantly longer operating times (p = 0.029) and longer hospital stay (p ......PURPOSE: To compare the characteristics and outcomes of exit strategies following percutaneous nephrolithotomy (PCNL) using the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study database. MATERIALS AND METHODS: Two matched data sets were prepared in order to compare...... stent only versus NT only and TTL versus NT only. Patients were matched on the exit strategy using the following variables: case volume of the center where they underwent PCNL, stone burden, the presence of staghorn stone, size of sheath used at percutaneous access, the presence of bleeding during...

  15. Jet Exit Rig Six Component Force Balance

    Science.gov (United States)

    Castner, Raymond; Wolter, John; Woike, Mark; Booth, Dennis

    2012-01-01

    A new six axis air balance was delivered to the NASA Glenn Research Center. This air balance has an axial force capability of 800 pounds, primary airflow of 10 pounds per second, and a secondary airflow of 3 pounds per second. Its primary use was for the NASA Glenn Jet Exit Rig, a wind tunnel model used to test both low-speed, and high-speed nozzle concepts in a wind tunnel. This report outlines the installation of the balance in the Jet Exit Rig, and the results from an ASME calibration nozzle with an exit area of 8 square-inches. The results demonstrated the stability of the force balance for axial measurements and the repeatability of measurements better than 0.20 percent.

  16. The Political Economy of Early Exit

    DEFF Research Database (Denmark)

    Schmitt, Carina; Starke, Peter

    2016-01-01

    Large-scale exit from the labour market began in the 1970s in many OECD countries. The literature indicates that individual early retirement decisions are facilitated by generous and accessible ‘pathways’ into retirement in the public pension system, unemployment insurance or disability benefits...... in the tradable sector, against a more traditional class-based logic of welfare state policy-making. Quantitative analysis of employment outcomes in 21 countries shows that the political economy of early exit clearly rests on the sectoral politics of cost-shifting....

  17. High School Exit Exams and Hispanics

    Science.gov (United States)

    Adam, Michelle

    2005-01-01

    This article deals with the report, entitled "State High School Exit Exams: A Maturing Reform", that addressed the achievement gaps that exist for minority and English language learner (ELL) populations. In this article, the author shows how Hispanics and ELLs lag behind Caucasians in terms of passing percentage in different subject areas. The…

  18. Entry and exit, cycles, and productivity growth

    NARCIS (Netherlands)

    C. van Ewijk

    1997-01-01

    This paper examines the impact of cycles on long-term growth in the presence of entry and exit of firms. It is argued that, whereas mild fluctuations may be beneficial for growth, more severe fluctuations will be detrimental for growth. The essential point is whether recessions go beyond the point t

  19. Determinants of Business Exits in Australia

    Directory of Open Access Journals (Sweden)

    Yongqiang Li

    2014-09-01

    Full Text Available The annually increasing firm exits have significant financial, legal and social impacts on productivity, employment and economic growth in Australia. However, evidence of the impacts of firm exits is sparse. This paper undertakes a first-ever study that empirically investigates the determinants and their impacts on firm churn. This paper is innovative to the literature in four aspects: (1 Local Region Areas (LGAs data, rarely available in other countries, has been used for the analysis; (2 using LGAs as the basic analytical unit is able to eliminate the heterogeneity problems encountered by other studies which are based on national and cross-national data; (3 panel data modelling techniques identify robust evidence; (4 systematic statistical tests guarantees the robustness of the results. The dataset, provided by Australia Bureau of Statistics, include 3462 observations of 577 Local Government Areas (LGAs during 2004-2009. The research identifies variables positively and negatively affecting the exits and finds that size matters in determining business exits. The last section concludes with a discussion of limitations and future research directions.

  20. Exit problems for oscillating compound Poisson process

    CERN Document Server

    Kadankova, Tetyana

    2011-01-01

    In this article we determine the Laplace transforms of the main boundary functionals of the oscillating compound Poisson process. These are the first passage time of the level, the joint distribution of the first exit time from the interval and the value of the overshoot through the boundary. Under certain conditions we establish the asymptotic behaviour of the mentioned functionals.

  1. Chaperone binding at the ribosomal exit tunnel

    DEFF Research Database (Denmark)

    Kristensen, Ole; Gajhede, Michael

    2003-01-01

    The exit tunnel region of the ribosome is well established as a focal point for interaction between the components that guide the fate of nascent polypeptides. One of these, the chaperone trigger factor (TF), associates with the 50S ribosomal subunit through its N-terminal domain. Targeting of TF...

  2. 14 CFR 121.585 - Exit seating.

    Science.gov (United States)

    2010-01-01

    ... this section, the suitability of each person it permits to occupy an exit seat, in accordance with this... public at all passenger loading gates and ticket counters at each airport where it conducts passenger...-holding district office. (o) Certificate holders shall assign seats prior to boarding consistent with...

  3. Epigenetics as a First Exit Problem

    Science.gov (United States)

    Aurell, E.; Sneppen, K.

    2002-01-01

    We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the λ prophage. The formalism defines a quantitative measure of robustness of inherited states.

  4. Effect of exit locations on ants escaping a two-exit room stressed with repellent

    Science.gov (United States)

    Wang, Shujie; Cao, Shuchao; Wang, Qiao; Lian, Liping; Song, Weiguo

    2016-09-01

    In order to investigate the effect of the distance between two exits on ant evacuation efficiency and the behavior of ants escaping from a two-exit room, we conducted ant egress experiments using Camponotus japonicus in multiple situations. We found that the ants demonstrated the phenomenon of "symmetry breaking" in this stress situation. It was also shown that different locations for the exits obviously affected the ants' egress efficiency by measuring the time intervals between individual egress and flow rate in eight repeated experiments, each of which contained five different distance between the two exits. In addition, it is demonstrated that there are differences between the predictions of Social Force Model of pedestrians and the behaviors of ants in stress conditions through comparing some important behavioral features, including position, trajectory, velocity, and density map.

  5. Mathematical design of a highway exit curve

    Science.gov (United States)

    Pakdemirli, Mehmet

    2016-01-01

    A highway exit curve is designed under the assumption that the tangential and normal components of the acceleration of the vehicle remain constant throughout the path. Using fundamental principles of physics and calculus, the differential equation determining the curve function is derived. The equation and initial conditions are cast into a dimensionless form first for universality of the results. It is found that the curves are effected by only one dimensionless parameter which is the ratio of the tangential acceleration to the normal acceleration. For no tangential acceleration, the equation can be solved analytically yielding a circular arc solution as expected. For nonzero tangential acceleration, the function is complicated and no closed-form solutions exist for the differential equation. The equation is solved numerically for various acceleration ratios. Discussions for applications to highway exits are given.

  6. Exits from unemployment : recall or new job

    OpenAIRE

    Muñoz-Bullón, Fernando; Alba, Alfonso; Arranz, José M.

    2006-01-01

    JEL Classification Numbers J21, J24 This paper studies transitions out of unemployment in Spain distinguishing between recall to the same employer and reemployment in a new job. We use a large sample of newly unemployed workers obtained from Social Security records for Spain. These data contain information about each individual's employer identy before and after the unemployment spell. A discrete-time duration model with competing risks of exits serves us to investigate the factors that in...

  7. Dynamic exit pupil trackers for autostereoscopic displays

    OpenAIRE

    Akşit, Kaan; Ölçer, Selim; Ürey, Hakan; Baghsiahi, Hadi; Surman, Phil; Willman, Eero; Selviah, David R.; Day, Sally

    2013-01-01

    Dynamic exit pupil trackers for autostereoscopic displays Kaan Akşit,1,* Hadi Baghsiahi,2 Phil Surman,3 Selim Ӧlçer,1 Eero Willman,2 David R. Selviah,2 Sally Day, 2 and Hakan Urey1 1Koç University, Department of Electrical Engineering Istanbul, 34450, Turkey 2University College London, UCL, Department of Electronic & Electrical Engineering, WC1E 7JE, London, UK 3De Montfort University, Department of Computer Technology, Leicester, UK * Abstract: This...

  8. Firm exit and armed conflict in Colombia

    OpenAIRE

    Camacho, Andriana; Rodriguez, Catherine

    2010-01-01

    This paper uses two unique panel data sets to study the causal effect that armed conflict has over entrepreneurial activity in Colombia. Using a fixed effect estimation methodology at the plant level and controlling for the possible endogeneity of armed conflict through the use of instrumental variables, we find that a one standard deviation in the number of guerrilla and paramilitary attacks in a municipality increases the probability of firm exit in 8.1 percentage points. This effect is str...

  9. Profile of State High School Exit Exam Policies. New Jersey

    Science.gov (United States)

    Center on Education Policy, 2011

    2011-01-01

    This individual profile provides information on New Jersey's high school exit exam standards and policies. Some of the categories presented include: (1) State exit exam policy; (2) Type of Test; (3) Purpose; (4) Major changes in exit exam policy since the 2009-10 school year for financial reasons; (5) Subjects tested on exam; (6) Grade exam first…

  10. Profile of State High School Exit Exam Policies. Ohio

    Science.gov (United States)

    Center on Education Policy, 2011

    2011-01-01

    This individual profile provides information on Ohio's high school exit exam standards and policies. Some of the categories presented include: (1) State exit exam policy; (2) Type of Test; (3) Purpose; (4) Major changes in exit exam policy since the 2009-10 school year for financial reasons; (5) Subjects tested on exam; (6) Grade exam first…

  11. Profile of State High School Exit Exam Policies. Oklahoma

    Science.gov (United States)

    Center on Education Policy, 2011

    2011-01-01

    This individual profile provides information on Oklahoma's high school exit exam standards and policies. Some of the categories presented include: (1) State exit exam policy; (2) Type of Test; (3) Purpose; (4) Major changes in exit exam policy since the 2009-10 school year for financial reasons; (5) Subjects tested on exam; (6) Grade exam first…

  12. Profile of State High School Exit Exam Policies. New York

    Science.gov (United States)

    Center on Education Policy, 2011

    2011-01-01

    This individual profile provides information on New York's high school exit exam standards and policies. Some of the categories presented include: (1) State exit exam policy; (2) Type of Test; (3) Purpose; (4) Major changes in exit exam policy since the 2009-10 school year for financial reasons; (5) Subjects tested on exam; (6) Grade exam first…

  13. A Legal Overview and History of High School Exit Exams

    Science.gov (United States)

    Sutton, Lenford

    2006-01-01

    State exit exams, also known as graduation tests, are tests that student must pass to graduate from high school. These tests are more influential than ever. Accordingly, in 2004, 20 states required students to pass an exit exam to graduate from high school, and six additional states will implement an exit exam by 2009. This affects more than half…

  14. Entry and Exit Stress Variation of Cold Rolling Strip

    Institute of Scientific and Technical Information of China (English)

    WANGDong—cheng

    2012-01-01

    The shortcomings of an exit stress variation formula which has been well accepted are analyzed~ it is found that the exit stress variation formula violates the premise of the law of volume constancy. The shortcomings of an en- try stress variation formula are analyzed too, and the basic assumption of the formula is uniform exit velocity. How- ever, for a rigid-plastic material uniform exit velocity implies that the lateral distributioi1 of elongation is uniform, so the exit stress must be uniform and any type of flatness defect is impossible, which is contrary to the practice. In fact, entry and exit velocity variation influence entry and exit stress variation, and entry and exit stress variation in- fluence entry and exit velocity variation too, so a precise explicit stress variation formula cannot be got easily. Con- sidering the relationship between stress variation and velocity variation, an iteration method is presented to calculate entry and exit stress variation of cold rolling strip. To avoid divergent phenomenon of the iteration course, a relaxa- tion factor method is adopted. The calculation results are compared with the entry and exit stress variation formula commonly used by many researchers. The difference is remarkable, while the result calculated agree more well with measured result if the exit elastic recovery zone is considered. Specially, the incoming flatnessI propagate efficiency calculated ~ives a more realistic result.

  15. EOS Terra Terra Constellation Exit/Future Maneuver Plans Update

    Science.gov (United States)

    Mantziaras, Dimitrios

    2016-01-01

    This EOS Terra Constellation Exit/Future Maneuver Plans Update presentation will discuss brief history of Terra EOM work; lifetime fuel estimates; baseline vs. proposed plan origin; resultant exit orbit; baseline vs. proposed exit plan; long term orbit altitude; revised lifetime proposal and fallback options.

  16. The exit distribution for iterated Brownian motion in cones

    OpenAIRE

    Banuelos, Rodrigo; DeBlassie, Dante

    2004-01-01

    We study the distribution of the exit place of iterated Brownian motion in a cone, obtaining information about the chance of the exit place having large magnitude. Along the way, we determine the joint distribution of the exit time and exit place of Brownian motion in a cone. This yields information on large values of the exit place (harmonic measure) for Brownian motion. The harmonic measure for cones has been studied by many authors for many years. Our results are sharper than any previousl...

  17. Exit time distribution in spherically symmetric two-dimensional domains

    CERN Document Server

    Rupprecht, J -F; Grebenkov, D S; Voituriez, R

    2014-01-01

    The distribution of exit times is computed for a Brownian particle in spherically symmetric two- dimensional domains (disks, angular sectors, annuli) and in rectangles that contain an exit on their boundary. The governing partial differential equation of Helmholtz type with mixed Dirichlet- Neumann boundary conditions is solved analytically. We propose both an exact solution relying on a matrix inversion, and an approximate explicit solution. The approximate solution is shown to be exact for an exit of vanishing size and to be accurate even for large exits. For angular sectors, we also derive exact explicit formulas for the moments of the exit time. For annuli and rectangles, the approximate expression of the mean exit time is shown to be very accurate even for large exits. The analysis is also extended to biased diffusion. Since the Helmholtz equation with mixed boundary conditions is encountered in microfluidics, heat propagation, quantum billiards, and acoustics, the developed method can find numerous appl...

  18. BST2/Tetherin Inhibition of Alphavirus Exit

    Directory of Open Access Journals (Sweden)

    Yaw Shin Ooi

    2015-04-01

    Full Text Available Alphaviruses such as chikungunya virus (CHIKV and Semliki Forest virus (SFV are small enveloped RNA viruses that bud from the plasma membrane. Tetherin/BST2 is an interferon-induced host membrane protein that inhibits the release of many enveloped viruses via direct tethering of budded particles to the cell surface. Alphaviruses have highly organized structures and exclude host membrane proteins from the site of budding, suggesting that their release might be insensitive to tetherin inhibition. Here, we demonstrated that exogenously-expressed tetherin efficiently inhibited the release of SFV and CHIKV particles from host cells without affecting virus entry and infection. Alphavirus release was also inhibited by the endogenous levels of tetherin in HeLa cells. While rubella virus (RuV and dengue virus (DENV have structural similarities to alphaviruses, tetherin inhibited the release of RuV but not DENV. We found that two recently identified tetherin isoforms differing in length at the N-terminus exhibited distinct capabilities in restricting alphavirus release. SFV exit was efficiently inhibited by the long isoform but not the short isoform of tetherin, while both isoforms inhibited vesicular stomatitis virus exit. Thus, in spite of the organized structure of the virus particle, tetherin specifically blocks alphavirus release and shows an interesting isoform requirement.

  19. Fatal exit the automotive black box debate

    CERN Document Server

    Kowalick, Tom

    2005-01-01

    "Fatal Exit: The Automotive Black Box Debate cuts through thirty years of political wrangling and institutional biases to provide an argument for the Motor Vehicle Event Data Recorder (MVEDR). This automotive equivalent of an airplane's flight recorder or black box is intended to solve the mysteries of car crashes and improve the safety of our roads. The reader is taken inside the automotive industry and the government highway safety establishment to foster an understanding of the politics and the positions on all sides of this safety debate. The author takes an unbiased approach, chronologically presenting each argument and uncovering the agendas and mandates of each of the stakeholders." "This publication is essential reading for all consumers who need to have their voices heard on this critical issue, as well as for attorneys, public safety advocates, public policy administrators, engineers, automotive professionals, journalists, and insurance executives."--Jacket.

  20. The story's end : a narrative analysis of entrepreneurial exit

    OpenAIRE

    Gill, Jameson

    2015-01-01

    Based on a period of participant observation I examine the exit of the Managing Director from a family owned business. The study reflects on theories of entrepreneurial exit at both the level of the individual and the organisation. Through the adoption of a two step empirical analysis based on narrative theory, conclusions are drawn regarding the events and the Managing Director’s actions which were antecedent to his announcement of exit. The article contributes insights regarding how an indi...

  1. Exit processes of micro-businesses: The decision to transfer

    OpenAIRE

    Leroy, Hannes; Manigart, Sophie; Meuleman, Miguel

    2007-01-01

    Ultimately all entrepreneurs are confronted with the exit of their business. When considering the large amount and increasing age of micro-business owners, this topic warrants more investigation than it has received so far. Our research sheds more light on the entrepreneurial exit process for micro-businesses. Starting from the theory of planned behavior (TPB), our study models the business exit as a dual-stage process of intentions prediction action. After testing the applicability of the TP...

  2. 14 CFR 25.813 - Emergency exit access.

    Science.gov (United States)

    2010-01-01

    ... region, if there are compensating factors to maintain the effectiveness of the exit. (3) For each Type...) Accurately state or illustrate the proper method of opening the exit, including the use of handholds; and... the loads imposed upon it when the door is subjected to the ultimate inertia forces, relative to...

  3. Towards an Orderly Exit Regime in English Higher Education

    Science.gov (United States)

    Fisher, Andrew

    2016-01-01

    In a competitive market, the exit of those suppliers who cannot offer an attractive product at an attractive price is seen as desirable. However, the consequences for consumers when their own supplier leaves the market in an unplanned or disorderly way may be undesirable. Exit regimes exist in regulated markets to ensure that consumers are not…

  4. Exit and voice in dutch social health insurance.

    NARCIS (Netherlands)

    Gress, S.; Delnoij, D.; Groenewegen, P.P.

    2003-01-01

    According to Hirschmann's concept of exit and voice, people have two options to make sure that firms or organisations realise what they (their consumers or members) are interested in (Hirschmann 1970). In the Dutch public health insurance system voice existed for a long time, but exit was only intro

  5. Exit Examinations, Peer Academic Climate, and Adolescents' Developmental Outcomes

    Science.gov (United States)

    Benner, Aprile D.

    2013-01-01

    Implications of high school exit examination performance were examined with a sample of 672 racial/ethnic minority students. Exit examination failure in the 10th grade was negatively linked to subsequent grade point average, school engagement, and school belonging one year later, controlling for outcomes prior to taking the examination.…

  6. Is the publication of exit poll results morally permissible?

    DEFF Research Database (Denmark)

    Sønderholm, Jørn

    2016-01-01

    This article is about exit polls. It addresses the question of whether or not it is morally permissible to publish exit poll results. The conclusion of the article is that an affirmative answer should be given to this question. In section 2, the master argument in favor of the moral permissibility...... of the publication of exit poll results is introduced. This is a strong argument. It is, however, argued that it might be the case that the conclusion of this argument should be rejected if there are other, and weightier, arguments against the idea that the publication of exit poll results is morally...... permissible. In section 3, the strongest arguments against the moral permissibility of the publication of exit poll results are outlined and discussed. The conclusion of this section is that all these arguments fail in their intended purpose. The conclusion of the article is therefore justified....

  7. Suicide, Canadian law, and Exit International's "peaceful pill".

    Science.gov (United States)

    Ogden, Russel D

    2010-11-01

    Australia's Exit International ("Exit") is probably the most visible and controversial right-to-die organization in the world. Founded by Dr. Philip Nitschke, Exit is known for do-it-yourself ("DIY") suicide workshops and a book banned in Australia: The Peaceful Pill Handbook. In 2009, Exit held its first workshop in Canada. Due to legal concerns, the Vancouver Public Library reneged on a commitment to give Exit a venue, so the workshop proceeded in the sanctuary of a church hall. This article summarizes the history of suicide law in Canada and gives an overview of the emerging DIY movement. A case report describes how a Canadian woman studied Exit's literature and learned how to import veterinary pentobarbital. In accordance with Exit's information, she ended her life. Ethical and legal implications for researching DIY suicide are discussed and it is argued that prohibition contributes to an undesirable situation of uncontrolled and unregulated suicide. Whether they are prohibited, permitted, or tolerated, suicide and assisted suicide are controversial. Their legal treatment in Canada is conflicting because suicide is not a crime but it is a serious offense to assist, encourage, or counsel someone to suicide. Individuals can lawfully take their lives, but they must act independently. This legal situation has given rise to a do-it-yourself ("DIY") right-to-die movement dedicated to technologies and information to enhance the possibilities for planned and humane suicide, while limiting the legal exposure of sympathetic third parties (Martin, 2010; Ogden 2001). My aim is to summarize the legal history of suicide in Canada and discuss the emerging social movement for DIY suicide and assistance in suicide. Exit International ("Exit"), based in Australia, is a leading organization in this movement. I present a case report that describes how a Canadian woman ended her life using DIY techniques learned from Exit. Some ethical and legal implications for researching DIY

  8. A Case Report of Rash at Peritoneal Dialysis Exit Site

    Directory of Open Access Journals (Sweden)

    Elvira O. Gosmanova MD, FASN

    2015-11-01

    Full Text Available The International Society for Peritoneal Dialysis recommends the regular application of topical antibiotic-containing preparations in addition to a routine exit site care to reduce the risk of exit site infection (ESI. Among these prophylactic antimicrobial preparations, topical gentamicin is one of the widely used and effective antibiotics for prevention of ESI and peritonitis in peritoneal dialysis (PD patients. Overall, topical gentamicin is well tolerated; however, its use can be associated with the development of allergic contact dermatitis (ACD. We describe a first reported case of PD catheter exit site contact ACD due to topical gentamicin mimicking ESI. The patient in this report developed worsening violaceous in color and pruritic rash surrounding the PD catheter exit site that appeared 3 weeks after the initiation of gentamicin cream. The association between development of rash and initiation of topical gentamicin led to a suspicion of local reaction to gentamicin rather than ESI. Skin biopsy confirmed ACD. Discontinuation of the provoking agent and subsequent treatment with topical hydrocortisone application led to a resolution of the exit site rash. Any rash at a PD catheter exit site should be considered infectious until proven otherwise. However, it is important to be aware of noninfectious etiologies of exit site rashes as the treatment of these 2 conditions differs.

  9. Jet Engine Nozzle Exit Configurations and Associated Systems and Methods

    Science.gov (United States)

    Mengle, Vinod G. (Inventor)

    2013-01-01

    Nozzle exit configurations and associated systems and methods are disclosed. An aircraft system in accordance with one embodiment includes a jet engine exhaust nozzle having an internal flow surface and an exit aperture, with the exit aperture having a perimeter that includes multiple projections extending in an aft direction. Aft portions of individual neighboring projections are spaced apart from each other by a gap, and a geometric feature of the multiple can change in a monotonic manner along at least a portion of the perimeter.

  10. Entry and Exit Dynamics of Nascent Business Owners

    DEFF Research Database (Denmark)

    Rocha, Vera; Carneiro, Anabela; Varum, Celeste

    2015-01-01

    This paper reports a comprehensive study on the dynamics of nascent business owners using a unique longitudinal matched employer–employee dataset. We follow over 157,000 individuals who leave paid employment and become business owners during the period 1992–2007. The contributions of this paper...... are twofold. First, we analyze both entry and exit, identifying and characterizing different profiles of individuals leaving paid employment to become business owners, and distinguishing exits by dissolution from exits by ownership transfer. Second, we provide new evidence on how particular experiences...... in the labor market and entry modes shape the post-entry dynamics of nascent business owners. By differentiating between different entry and exit routes, this paper provides new evidence on different human capital patterns among nascent business owners and on key determinants of entrepreneurial survival. Our...

  11. Direct exit-wave reconstruction from a single defocused image.

    Science.gov (United States)

    Morgan, A J; Martin, A V; D'Alfonso, A J; Putkunz, C T; Allen, L J

    2011-01-01

    We propose a direct, non-iterative method for the exact recovery of the complex wave in the exit-surface plane of a coherently illuminated object from a single defocused image. The method is applicable for a wide range of illumination conditions. The defocus range is subject to certain conditions, which if satisfied allow the complex exit-surface wave to be directly recovered by solving a set of linear equations. These linear equations, whose coefficients depend on the incident illumination, are obtained by analyzing the autocorrelation function of an auxiliary wave which is related to the exit-surface wave in a simple way. This autocorrelation is constructed by taking the inverse Fourier transform of the defocused image. We present an experimental proof of concept by recovering the exit-surface wave of a microfiber illuminated by a plane wave formed using a HeNe laser.

  12. A Novel Pathway that Coordinates Mitotic Exit with Spindle Position

    OpenAIRE

    Nelson, Scott A.; Cooper, John A.

    2007-01-01

    In budding yeast, the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves into the neck between the mother and bud. This checkpoint works by inhibiting the mitotic exit network (MEN), a signaling cascade initiated and controlled by Tem1, a small GTPase. Tem1 is regulated by a putative guanine exchange factor, Lte1, but the function and regulation of Lte1 remains poorly understood. Here, we identify novel components of the checkpoint that operate upstream of L...

  13. How extremist experiences become valuable knowledge in EXIT programmers

    DEFF Research Database (Denmark)

    Christensen, Tina Wilchen

    2015-01-01

    On the basis of a neo-Vygotskian approach the article analyses how former neo-Nazis, together with other staff at Fryshuset, a youth centre in Stockholm, Sweden, have developed the organisation EXIT, which helps people leave the extremist right. The article describes the processes former neo...... like EXIT aimed at helping others leave what they have come to view as a destructive and anti-democratic lifestyle....

  14. A Modified EXIT-to-ECMO with Optional Reservoir Circuit for Use during an EXIT Procedure Requiring Thoracic Surgery

    Science.gov (United States)

    Matte, Gregory S.; Connor, Kevin R.; Toutenel, Nathalia A.; Gottlieb, Danielle; Fynn-Thompson, Francis

    2016-01-01

    Abstract: A 34 year old mother with a history of polyhydraminos and premature rupture of membranes presented for an ex utero intrapartum treatment (EXIT) procedure to deliver her 34 week gestation fetus. The fetus had been diagnosed with a large cervical mass which significantly extended into the right chest. The mass compressed and deviated the airway and major neck vessels posteriorly. Imaging also revealed possible tumor involvement with the superior vena cava and right atrium. The plan was for potential extracorporeal membrane oxygenation (ECMO) during the EXIT procedure (EXIT-to-ECMO) and the potential for traditional cardiopulmonary bypass (CPB) for mediastinal tumor resection. A Modified EXIT-To-ECMO with Optional Reservoir (METEOR) circuit was devised to satisfy both therapies. A fetal airway could not be established during the EXIT procedure and so the EXIT-to-ECMO strategy was utilized. The fetus was then delivered and transferred to an adjoining operating room (OR). Traditional cardiopulmonary bypass with a cardiotomy venous reservoir (CVR) was utilized during the establishment of an airway, tumor biopsy and partial resection. The patient was eventually transitioned to our institution's standard ECMO circuit and then transferred to the intensive care unit. The patient was weaned from ECMO on day of life (DOL) eight and had a successful tumor resection on DOL 11. The patient required hospitalization for numerous interventions including cardiac surgery at 4 months of age. She was discharged to home at 5 months of age. PMID:27134307

  15. Mitotic Exit Control as an Evolved Complex System

    Energy Technology Data Exchange (ETDEWEB)

    Bosl, W; Li, R

    2005-04-25

    The exit from mitosis is the last critical decision a cell has to make during a division cycle. A complex regulatory system has evolved to evaluate the success of mitotic events and control this decision. Whereas outstanding genetic work in yeast has led to rapid discovery of a large number of interacting genes involved in the control of mitotic exit, it has also become increasingly difficult to comprehend the logic and mechanistic features embedded in the complex molecular network. Our view is that this difficulty stems in part from the attempt to explain mitotic exit control using concepts from traditional top-down engineering design, and that exciting new results from evolutionary engineering design applied to networks and electronic circuits may lend better insights. We focus on four particularly intriguing features of the mitotic exit control system: the two-stepped release of Cdc14; the self-activating nature of Tem1 GTPase; the spatial sensor associated with the spindle pole body; and the extensive redundancy in the mitotic exit network. We attempt to examine these design features from the perspective of evolutionary design and complex system engineering.

  16. Gas turbine combustor exit piece with hinged connections

    Energy Technology Data Exchange (ETDEWEB)

    Charron, Richard C.; Pankey, William W.

    2016-04-26

    An exit piece (66) with an inlet throat (67) that conducts a combustion gas flow (36A) in a path (82) from a combustor (63) to an annular chamber (68) that feeds the first blade section (37) of a gas turbine (26). The exit piece further includes an outlet portion (69) that forms a circumferential segment of the annular chamber. The outlet portion interconnects with adjacent outlet portions by hinges (78A, 78B, 80A, 80B). Each hinge may have a hinge axis (82A, 82B) parallel to a centerline (21) of the turbine. Respective gas flows (36A) are configured by an assembly (60) of the exit pieces to converge on the feed chamber (68) into a uniform helical flow that drives the first blade section with minimal circumferential variations in force.

  17. Comparison of exit time moment spectra for extrinsic metric balls

    DEFF Research Database (Denmark)

    Hurtado, Ana; Markvorsen, Steen; Palmer, Vicente

    We prove explicit upper and lower bounds for the $L^1$-moment spectra for the Brownian motion exit time from extrinsic metric balls of submanifolds $P^m$ in ambient Riemannian spaces $N^{n}$. We assume that $P$ and $N$ both have controlled radial curvatures (mean curvature and sectional curvature......, respectively) as viewed from a pole in $N$. The bounds for the exit moment spectra are given in terms of the corresponding spectra for geodesic metric balls in suitably warped product model spaces. The bounds are sharp in the sense that equalities are obtained in characteristic cases. As a corollary we also...

  18. Some Features of Aerodynamics of Cyclonic Chamber with Free Exit

    Directory of Open Access Journals (Sweden)

    A. N. Orekhov

    2014-06-01

    Full Text Available The paper cites results of an experimental research in aerodynamics of a cyclonic chamber with a free exit that has a large relative length. Distributions of aerodynamic stream characteristics depending on geometry of working volume of the cyclonic chamber are given in the paper. Calculative dependences are proposed in the paper.

  19. Embracing the Exit: Assessment, Trust, and the Teaching of Writing

    Science.gov (United States)

    Eng, Joseph

    2006-01-01

    Historically, the Composition Program at Eastern Washington University (EWU), a comprehensive university in Cheney, WA, required a single essay sample from each composition student as the final exit exam; in practice, a student passed or failed the course based on an in-class argumentative essay, written in three consecutive class periods. Such a…

  20. The Exit Poll: An Environmental Scanning Technique for School Districts.

    Science.gov (United States)

    House, Jess E.

    1989-01-01

    Exit polling of school district election returns is a form of environmental scanning that can provide information needed for strategic planning and be used to increase the effectiveness of school election campaigns. This technique is recommended for all school districts dependent on voter approval to meet revenue needs. (11 references) (MLH)

  1. After exit: Academic achievement patterns of former English language learners.

    Directory of Open Access Journals (Sweden)

    Ester J. de Jong

    2004-09-01

    Full Text Available With few exceptions, accountability systems for programs for English language learners (ELLs have focused on the achievement patterns of ELLs who are still considered “limited English proficient” and program evaluations have been unable to answer the question whether ELLs actually catch up with English proficient peers after attending a bilingual or English as a Second Language (ESL program. Disaggregating data for former ELLs can therefore provide important information for long-term district and program accountability. The study was concerned with the achievement patterns in English language arts, Math, and Science of former ELLs who attended a bilingual and a English as a Second Language (ESL program. It also explored whether length of program participation and grade level exited played a significant role in predicting academic achievement patterns for these exited students. Results indicate that 4th grade students more closely paralleled non- ELL students’ achievement patterns than 8th grade students, particularly for the BE students. While length of program participation is not a significant predictor of former ELLs’ academic success, exit grade does emerge as an important variable to take into consideration in setting exit guidelines.

  2. EXIT Chart Analysis of Binary Message-Passing Decoders

    DEFF Research Database (Denmark)

    Lechner, Gottfried; Pedersen, Troels; Kramer, Gerhard

    2007-01-01

    be extended to channels with larger output alphabets. By increasing the output alphabet from hard decisions to four symbols, a gain of more than 1.0 dB is achieved using optimized codes. For this code optimization, the mixing property of EXIT functions has to be modified to the case of binary message...

  3. Congenital Cervical Teratoma: Anaesthetic Management (The EXIT Procedure

    Directory of Open Access Journals (Sweden)

    Ferruh Bilgin

    2009-01-01

    Full Text Available Ex utero intrapartum treatment (EXIT is a procedure performed during caesarean section with preservation of fetal-placental circulation, which allows the safe handling of fetal airways with risk of airways obstruction. This report aimed at describing a case of anaesthesia for EXIT in a fetus with cervical teratoma. A 30-year-old woman, 70 kg, 160 cm, gravida 2, para 1, was followed because of polyhydramniosis diagnosed at 24 weeks′ gestation. During a routine ultrasonographic examination at 35 weeks′ gestation, it was noticed that the fetus had a tumoral mass on the anterior neck, the mass had cystic and calcified components and with a size of was 10 x 6 x5 cm. The patient with physical status ASA I, was submitted to caesarean section under general anaesthesia with mechanically controlled ventilation for exutero intrapartum treatment (EXIT. Anaesthesia was induced in rapid sequence with fentanyl, propofol and rocuronium and was maintained with isoflurane in 2.5 at 3 % in O 2 and N 2 O (50%. After hysterotomy, fetus was partially released assuring uterus-placental circulation, followed by fetal laryngoscopy and tracheal intuba-tion. The infant was intubated with an uncuffed, size 2.5 endotracheal tube. Excision of the mass was performed under general anaesthesia. After surgical intervention, on the fourth postoperative day, the infant was extubated and the newborn was discharged to the pediatric neonatal unit and on the seventh day postoperatively to home without complications. Major recommendations for EXIT are maternal-fetal safety, uterine relaxation to maintain uterine volume and uterus-placental circulation, and fetal immobility to help airway handling. We report one case of cervical teratoma managed successfully with EXIT procedure.

  4. An UHV-compatible fixed-exit two-crystal monochromator

    Science.gov (United States)

    Kirkland, J. P.; Elam, W. T.

    1995-02-01

    Simplicity, symmetric design, variable energy range, and support for both sides of the crystals are features of a new fixed-exit crystal monochromator that has been designed, built, and tested. It is less complex; therefore it is less expensive to build, easier to understand, and easier to maintain. The design is a variation of the Cowan boomerang design. Most of the high-precision surfaces are bars ground in parallel. Crystals are supported on both ends by carriages with high-precision ball-bearing wheels. These bearings roll along the bars to carry the crystals and to actuate the rotation of the crystals. By supporting crystals on both sides, water-cooling and dynamic crystal bender systems can be incorporated without adversely affecting the crystal stability. The system is highly symmetric, with no preferred orientation for entrance and exit beams. Angular ranges, and therefore energy ranges, for the system are easily varied by changing the length of the boomerang arms. The system is compact, with an angular range of 80°-3.5° for theta fitting within a length of 840 mm. This angular range corresponds to an energy range of 2.0-30 keV for Si(111).

  5. Composite Control of Precalciner Exit Temperature in Cement Rotary Kiln

    Institute of Scientific and Technical Information of China (English)

    赵晨; 诸静

    2003-01-01

    A composite control strategy for the precalciner exit temperature in cement kiln is introduced based on a mathematical model. In this model, the raw meal flow, coal powder flow and wind flow are taken as three input variables, the clinker fow and exit teperature of cement kiln are output variables, and other influencing factors are considered as disturbance. A composite control system is synthesied by integrating self-learning PID, fuzzy and feedforward function into a combined controller, and the arithmetics for the self-learning PID controller, fuzzy controller and feedforward controller are elaborated respectively. The control strategy has been realized by software in real practice at cement factory. Application results show that the composite control technology is superior to the general PID control in control effect, and is suitable to the industrial process control with slow parameter variation, nonlinearity and uncertainty.

  6. Simulation of stochastic diffusion via first exit times

    Science.gov (United States)

    Lötstedt, Per; Meinecke, Lina

    2015-11-01

    In molecular biology it is of interest to simulate diffusion stochastically. In the mesoscopic model we partition a biological cell into unstructured subvolumes. In each subvolume the number of molecules is recorded at each time step and molecules can jump between neighboring subvolumes to model diffusion. The jump rates can be computed by discretizing the diffusion equation on that unstructured mesh. If the mesh is of poor quality, due to a complicated cell geometry, standard discretization methods can generate negative jump coefficients, which no longer allows the interpretation as the probability to jump between the subvolumes. We propose a method based on the mean first exit time of a molecule from a subvolume, which guarantees positive jump coefficients. Two approaches to exit times, a global and a local one, are presented and tested in simulations on meshes of different quality in two and three dimensions.

  7. Calcium Signaling and Meiotic Exit at Fertilization in Xenopus Egg

    Directory of Open Access Journals (Sweden)

    Alexander A. Tokmakov

    2014-10-01

    Full Text Available Calcium is a universal messenger that mediates egg activation at fertilization in all sexually reproducing species studied. However, signaling pathways leading to calcium generation and the mechanisms of calcium-induced exit from meiotic arrest vary substantially among species. Here, we review the pathways of calcium signaling and the mechanisms of meiotic exit at fertilization in the eggs of the established developmental model, African clawed frog, Xenopus laevis. We also discuss calcium involvement in the early fertilization-induced events in Xenopus egg, such as membrane depolarization, the increase in intracellular pH, cortical granule exocytosis, cortical contraction, contraction wave, cortical rotation, reformation of the nuclear envelope, sperm chromatin decondensation and sister chromatid segregation.

  8. Customer Protest: Exit, Voice or Negative Word of Mouth

    Directory of Open Access Journals (Sweden)

    Solvang, B. K.

    2008-01-01

    Full Text Available Of the three forms of protest the propensity of word of mouth (WOM seems to be the most common, and the most exclusive form of protest seems to be exit. The propensity for voice lies in between. The costs linked to voice influence the propensity for WOM. The customers seem to do an evaluation between the three forms of protest, yet the rational picture of the customers should be moderated.Leaders should improve their treatment of the customers making complaints. The more they can treat customer complaints in an orderly and nice way the less informal negative word of mouth activity they will experience and they will reduce the exit propensity and lead the customers to the complain organisation. They should also ensure that their customers feel they get equal treatment by the staff.

  9. The exit-time problem for a Markov jump process

    Energy Technology Data Exchange (ETDEWEB)

    Burch, N. [Gonzaga Univ., Spokane, WA (United States); D' Elia, Marta [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lehoucq, Richard B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-12-15

    The purpose of our paper is to consider the exit-time problem for a finite-range Markov jump process, i.e, the distance the particle can jump is bounded independent of its location. Such jump diffusions are expedient models for anomalous transport exhibiting super-diffusion or nonstandard normal diffusion. We refer to the associated deterministic equation as a volume-constrained nonlocal diffusion equation. The volume constraint is the nonlocal analogue of a boundary condition necessary to demonstrate that the nonlocal diffusion equation is well-posed and is consistent with the jump process. A critical aspect of the analysis is a variational formulation and a recently developed nonlocal vector calculus. Furthermore, this calculus allows us to pose nonlocal backward and forward Kolmogorov equations, the former equation granting the various moments of the exit-time distribution.

  10. The exit-time problem for a Markov jump process

    Science.gov (United States)

    Burch, N.; D'Elia, M.; Lehoucq, R. B.

    2014-12-01

    The purpose of this paper is to consider the exit-time problem for a finite-range Markov jump process, i.e, the distance the particle can jump is bounded independent of its location. Such jump diffusions are expedient models for anomalous transport exhibiting super-diffusion or nonstandard normal diffusion. We refer to the associated deterministic equation as a volume-constrained nonlocal diffusion equation. The volume constraint is the nonlocal analogue of a boundary condition necessary to demonstrate that the nonlocal diffusion equation is well-posed and is consistent with the jump process. A critical aspect of the analysis is a variational formulation and a recently developed nonlocal vector calculus. This calculus allows us to pose nonlocal backward and forward Kolmogorov equations, the former equation granting the various moments of the exit-time distribution.

  11. A Study on the Exit and Entry Frontier Inspection System of Germany%德国出入境边防检查制度研究

    Institute of Scientific and Technical Information of China (English)

    安翠丽

    2013-01-01

    Very a few studies are conducted on the exit and entry frontier inspection system of Germany, one of the member states of European Union and Schengen states. Starting from the point of the exit and entry frontier inspection system of Germany, this article discusses three corresponding measures of improving and perfecting the exit and entry frontier inspection system of China on the basis of mainly studying the legal bases, institution settings and inspection models of the exit and entry frontier inspection of Germany. They are: further improving laws and regulations of the exit and entry frontier inspection;reforming institution settings of the exit and entry frontier inspection organs of China to build unified port control and service systems; further improving the operation systems of the exit and entry frontier inspection of China.%  德国作为欧盟成员国及申根国家之一,我们对于其出入境边防检查制度的研究却寥寥无几。本文从德国出入境边防检查制度入手,重点研究了德国出入境边防检查的法律基础、机构设置和检查模式,并从这三方面探讨改进和完善我国出入境边防检查的三项措施:进一步完善出入境边防检查法律法规;改革我国的出入境边防检查机关机构设置,建立统一的口岸查控与服务体系;进一步完善我国出入境边防检查运行体制。

  12. Renascent Entrepreneurship : Entrepreneurial Preferences Subsequent to Firm Exit

    OpenAIRE

    STAM, Erik; Audretsch, David B.; Meijaard, Joris

    2006-01-01

    Why should individuals that have exited their firm consider re-entering into entrepreneurship, i.e. become renascent entrepreneurs? According to the logic of economic models of firm dynamics there is no reason to re-enter into entrepreneurship following termination of a previous firm. In contrast, research on nascent entrepreneurship has shown the positive effect of entrepreneurial experience on planning a new firm start. Based on the empirical evidence from a database consisting of ex-entrep...

  13. EXIT-constrained BICM-ID Design using Extended Mapping

    OpenAIRE

    Fukawa, Kisho; Ormsub, Soulisak; Tölli, Antti; Anwar, Khoirul; Matsumoto, Tad

    2012-01-01

    This article proposes a novel design framework, EXIT-constrained binary switching algorithm (EBSA), for achieving near Shannon limit performance with single parity check and irregular repetition coded bit interleaved codedmodulation and iterative detection with extended mapping (SI-BICM-ID-EM). EBSA is composed of node degree allocation optimization using linear programming (LP) and labeling optimization based on adaptive binary switching algorithm jointly. This technique achieves exact match...

  14. On asymptotic exit-time control problems lacking coercivity

    OpenAIRE

    Motta, Monica; Sartori, Caterina

    2014-01-01

    International audience The research on a class of asymptotic exit-time problems with a vanishing Lagrangian, begun in [M. Motta and C. Sartori, Nonlinear Differ. Equ. Appl. Springer (2014).] for the compact control case, is extended here to the case of unbounded controls and data, including both coercive and non-coercive problems. We give sufficient conditions to have a well-posed notion of generalized control problem and obtain regularity, characterization and approximation results for th...

  15. Exit Options in Corporate Finance: Liquidity versus Incentives

    OpenAIRE

    Aghion, Philippe; Bolton, Patrick; Tirole, Jean

    2004-01-01

    This paper provides a first study of the optimal design of active monitors' exit options in a problem involving a demand for liquidity and costly monitoring of the issuer. Optimal incentives to monitor the issuer may involve restricting the monitor's right to sell her claims on the firm's cash-flow early. But the monitor will then require a liquidity premium for holding such an illiquid claim. In general, therefore, there will be a trade off between incentives and liquidity. The paper highlig...

  16. Folding and escape of nascent proteins at ribosomal exit tunnel

    OpenAIRE

    Thuy, Bui Phuong; Hoang, Trinh Xuan

    2016-01-01

    We investigate the interplay between post-translational folding and escape of two small single-domain proteins at the ribosomal exit tunnel by using Langevin dynamics with coarse-grained models. It is shown that at temperatures lower or near the temperature of the fastest folding, folding proceeds concomitantly with the escape process, resulting in vectorial folding and enhancement of foldability of nascent proteins. The concomitance between the two processes, however, deteriorates as tempera...

  17. Mitotic exit: Determining the PP2A dephosphorylation program.

    Science.gov (United States)

    Pereira, Gislene; Schiebel, Elmar

    2016-08-29

    In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55's dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis. PMID:27551057

  18. Exits in the gasoline market: evidence from Austria

    OpenAIRE

    Nikolic, Adriana; Weiss, Christoph

    2013-01-01

    The retail gasoline market is going through a process of restructuring and consolidation in many developed economies. During the past decade, a large number of gasoline stations have been closed down. The present paper aims to investigate this process. One of the key characteristics of the retail gasoline market is that competition is localised, and this spatial dimension of competition has to be taken into account when investigating the (binary) decision of whether or not to exit...

  19. First exit times of harmonically trapped particles: a didactic review

    International Nuclear Information System (INIS)

    We revise the classical problem of characterizing first exit times of a harmonically trapped particle whose motion is described by a one- or multidimensional Ornstein–Uhlenbeck process. We start by recalling the main derivation steps of a propagator using Langevin and Fokker–Planck equations. The mean exit time, the moment-generating function and the survival probability are then expressed through confluent hypergeometric functions and thoroughly analyzed. We also present a rapidly converging series representation of confluent hypergeometric functions that is particularly well suited for numerical computation of eigenvalues and eigenfunctions of the governing Fokker–Planck operator. We discuss several applications of first exit times, such as the detection of time intervals during which motor proteins exert a constant force onto a tracer in optical tweezers single-particle tracking experiments; adhesion bond dissociation under mechanical stress; characterization of active periods of trend-following and mean-reverting strategies in algorithmic trading on stock markets; relation to the distribution of first crossing times of a moving boundary by Brownian motion. Some extensions are described, including diffusion under quadratic double-well potential and anomalous diffusion. (topical review)

  20. First exit times of harmonically trapped particles: a didactic review

    Science.gov (United States)

    Grebenkov, Denis S.

    2015-01-01

    We revise the classical problem of characterizing first exit times of a harmonically trapped particle whose motion is described by a one- or multidimensional Ornstein-Uhlenbeck process. We start by recalling the main derivation steps of a propagator using Langevin and Fokker-Planck equations. The mean exit time, the moment-generating function and the survival probability are then expressed through confluent hypergeometric functions and thoroughly analyzed. We also present a rapidly converging series representation of confluent hypergeometric functions that is particularly well suited for numerical computation of eigenvalues and eigenfunctions of the governing Fokker-Planck operator. We discuss several applications of first exit times, such as the detection of time intervals during which motor proteins exert a constant force onto a tracer in optical tweezers single-particle tracking experiments; adhesion bond dissociation under mechanical stress; characterization of active periods of trend-following and mean-reverting strategies in algorithmic trading on stock markets; relation to the distribution of first crossing times of a moving boundary by Brownian motion. Some extensions are described, including diffusion under quadratic double-well potential and anomalous diffusion.

  1. Discrete Element Crowd Model for Pedestrian Evacuation Through an Exit

    CERN Document Server

    Lin, Peng; Lo, Siuming

    2016-01-01

    A series of accidents caused by crowd within the last decades evoked a lot of scientific interest in modeling the movement of pedestrian crowds. Based on discrete element method, a granular dynamic model, in which human body is simplified as self-driven sphere, is proposed to simulate the characteristics of crowd flow through an exit. In this model, the repulsive force among people is considered to have an anisotropic feature, and the physical contact force due to body deformation is quantified by the Hertz contact model. The movement of human body is simulated by applying the second Newton's law. The crowd flow through an exit at different desired velocities is studied and simulation results indicated that crowd flow exhibits three distinct states, i.e., smooth state, transition state and phase separation state. In the simulation, clogging phenomenon occurs more easily when the velocity of desired is high and the exit may as a result be totally blocked at a desired velocity of 1.6m/s or above, leading to fas...

  2. Exit times for a class of random walks: exact distribution results

    DEFF Research Database (Denmark)

    Jacobsen, Martin

    2011-01-01

    the exit possible has a Laplace transform which is a rational function. The expected exit time is also determined and the paper concludes with exact distribution results concerning exits from bounded intervals. The proofs use simple martingale techniques together with some classical expansions...

  3. Quantitative research on exit barrier in construction enterprise with different ownership

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-dong; XIAO Hou-zhong; ZHANG Zhi-hui; WANG Dan-song

    2006-01-01

    "Exit barrier" means the obstacle keeping enterprises from competing even though their profits may be negative. This paper presents quantitative research on the exit barrier's effect on the Chinese construction industry using questionnaire investigation. The exit barrier was classified into six categories, and then the categories were ranked and analyzed according to the respondents from the state-owned enterprises (SOEs) and non stateowned enterprises (NSOEs), respectively. The main obstacles related to the exit barrier in SOEs and NSOEs were revealed. Finally, suggestions were provided to diminish the exit barrier effect on the construction industry.

  4. A predictive theory of intentions to exit street-level prostitution.

    Science.gov (United States)

    Cimino, Andrea N

    2012-10-01

    Street-level prostitution is notoriously difficult to escape and rarely do women exit prostitution on their first attempt or without experiencing serious negative consequences to their physical or mental health. Unfortunately, few theories exist that explain the exiting process and those that do exist are difficult to test quantitatively. This article applies the integrative model of behavioral prediction to examine intentions to exit prostitution through attitudes, norms, and self-efficacy beliefs that underlie a woman's intention to exit prostitution. Constructs unique prostitution--agency and societal context--enhance the model. This theory may explain and predict an exit from street-level prostitution.

  5. Do specialists exit the firm outsourcing its R&D?

    DEFF Research Database (Denmark)

    Wang, Wenjing

    Do specialists exit the firm increasingly outsourcing its research and development (R&D) work? Although this question is critical in understanding how R&D outsourcing links to innovation performance, the answer is not yet clear. This paper proposes that the optimal level of firm's internal...... employment of R&D specialists decreases with the deepening of R&D outsourcing but increases with the broadening of R&D outsourcing. These relations can be inferred from previous empirical studies as well as our theoretical analysis, and are supported by the empirical evidence from estimations of correlated...

  6. Measurements of temperature profiles at the exit of small rockets.

    Science.gov (United States)

    Griggs, M; Harshbarger, F C

    1966-02-01

    The sodium line reversal technique was used to determine the reversal temperature profile across the exit of small rockets. Measurements were made on one 73-kg thrust rocket, and two 23-kg thrust rockets with different injectors. The large rocket showed little variation of reversal temperature across the plume. However, the 23-kg rockets both showed a large decrease of reversal temperature from the axis to the edge of the plume. In addition, the sodium line reversal technique of temperature measurement was compared with an infrared technique developed in these laboratories.

  7. CONSIDERATIONS REGARDING MONETARY AND FISCAL EXIT STRATEGIES FROM THE CRISIS

    Directory of Open Access Journals (Sweden)

    MARIA VASILESCU

    2010-03-01

    Full Text Available The recent financial crisis and all unusual monetary and fiscal policy reactions have stressed the importance to be given to understand macroeconomic consequences of policy interventions and their interactions. This profound crisis has led to both nonstandard policy actions of various authorities around the globe, but it has also revealed limitations of traditional modeling tools to guide policymakers’ actions until nowadays. The delicate state of governments’ accounts in many countries is a consequence of the strong fiscal policy reactions, giving rise to risks of a potential fiscal crisis. Issues regarding monetary and fiscal policy decisions interactions are, therefore, the key element for successful exit strategies from the crisis.

  8. Improved social force model based on exit selection for microscopic pedestrian simulation in subway station

    Institute of Scientific and Technical Information of China (English)

    郑勋; 李海鹰; 孟令云; 许心越; 陈旭

    2015-01-01

    An improved social force model based on exit selection is proposed to simulate pedestrians’ microscopic behaviors in subway station. The modification lies in considering three factors of spatial distance, occupant density and exit width. In addition, the problem of pedestrians selecting exit frequently is solved as follows: not changing to other exits in the affected area of one exit, using the probability of remaining preceding exit and invoking function of exit selection after several simulation steps. Pedestrians in subway station have some special characteristics, such as explicit destinations, different familiarities with subway station. Finally, Beijing Zoo Subway Station is taken as an example and the feasibility of the model results is verified through the comparison of the actual data and simulation data. The simulation results show that the improved model can depict the microscopic behaviors of pedestrians in subway station.

  9. Exit flow measurements of a centrifugal pump impeller

    International Nuclear Information System (INIS)

    Discharge flows from a centrifugal pump impeller with a specific speed of 150 [rpm, m3/min, m] were experimentally investigated. A large axisymmetric collector instead of a volute casing was installed to obtain circumferentially uniform flow, i.e. without interaction of the impeller and the volute. The unsteady flow was measured at the impeller exit and vaneless diffuser using a hot film probe and a pressure transducer. The flow at impeller exit showed pronounced jet-wake flow patterns. The wake, which was on the suction/hub side at high flow rate, became enlarged pitchwisely on both the hub and the shroud side as the flow rate decreases. The pitchwise non-uniformity of the flow rapidly decreased along the downstream and the non-uniformity almost disappeared at radius ratio of 1.18 for medium flow rate. The mean vaneless diffuser flow was reasonably predicted using a one dimensional analysis when an empirical constant was used to specify the skin friction coefficient. The data can be used for a centrifugal pump impeller design and validation of CFD codes and flow modeling

  10. Graceful exit from a stringy landscape via MSSM inflation

    Science.gov (United States)

    Allahverdi, Rouzbeh; Frey, Andrew R.; Mazumdar, Anupam

    2007-07-01

    The cosmological evolution of the string landscape is expected to consist of multiple stages of old inflation with a large cosmological constant, each of which ends by tunneling. Old inflation has a well-known graceful exit problem as the observable universe becomes empty, devoid of any entropy. Simultaneously, in the quest for reheating the right degrees of freedom, it is important that the final stage of inflation reheat the standard model sector. It is known that inflation can occur naturally along a flat direction of the minimal supersymmetric standard model (MSSM), solving the reheating problem, but the initial conditions require a large degree of fine-tuning. In this paper, we study how inflation of a MSSM flat direction can be embedded into the string theory landscape to solve both the graceful exit problem of old inflation and the fine-tuning problem of MSSM inflation, elaborating on ideas of Bousso and Polchinski. The fluctuations of the MSSM flat direction during old inflation create regions with initial conditions favorable for eternal inflation, which also allows the cosmological constant to continue to relax. This final phase of inflation also provides all the usual benefits of MSSM inflation, including straightforward reheating into standard model degrees of freedom.

  11. Competitive electricity markets, prices and generator entry and exit

    Science.gov (United States)

    Ethier, Robert George

    The electric power industry in the United States is quickly being deregulated and restructured. In the past, new electric generation capacity was added by regulated utilities to meet forecasted demand levels and maintain reserve margins. With competitive wholesale generation, investment will be the responsibility of independent private investors. Electricity prices will assume the coordinating function which has until recently been the responsibility of regulatory agencies. Competitive prices will provide the entry and exit signals for generators in the future. Competitive electricity markets have a distinctive price formation process, and thus require a specialized price model. A mean-reverting price process with stochastic jumps is proposed as an appropriate long-run price process for annual electricity prices. This price process is used to develop an analytic real options model for private investment decisions. The required recursive infinite series solutions have not been widely used for real option models. Entry thresholds and asset values for competitive wholesale electricity markets, and exit decisions for plants with significant retirement costs (i.e. nuclear power plants), are examined. The proposed model results in significantly lower trigger prices for both entry and exit decisions, and higher asset values, when compared with other standard models. The model is used to show that the incentives for retiring a nuclear plant are very sensitive to the treatment of decommissioning costs (e.g. if plant owners do not face full decommissioning costs, retirement decisions may be economically premature.) An econometric model of short-run price behavior is estimated by the method of maximum likelihood using daily electricity prices from markets in the USA and Australia. The model specifies two mean reverting price processes with stochastic Markov switching between the regimes, which allows discontinuous jumps in electricity prices. Econometric tests show that a two

  12. High-Flow Jet Exit Rig Designed and Fabricated

    Science.gov (United States)

    Buehrle, Robert J.; Trimarchi, Paul A.

    2003-01-01

    The High-Flow Jet Exit Rig at the NASA Glenn Research Center is designed to test single flow jet nozzles and to measure the appropriate thrust and noise levels. The rig has been designed for the maximum hot condition of 16 lbm/sec of combustion air at 1960 R (maximum) and to produce a maximum thrust of 2000 lb. It was designed for cold flow of 29.1 lbm/sec of air at 530 R. In addition, it can test dual-flow nozzles (nozzles with bypass flow in addition to core flow) with independent control of each flow. The High- Flow Jet Exit Rig was successfully fabricated in late 2001 and is being readied for checkout tests. The rig will be installed in Glenn's Aeroacoustic Propulsion Laboratory. The High-Flow Jet Exit Rig consists of the following major components: a single component force balance, the natural-gas-fueled J-79 combustor assembly, the plenum and manifold assembly, an acoustic/instrumentation/seeding (A/I/S) section, a table, and the research nozzles. The rig will be unique in that it is designed to operate uncooled. The structure survives the 1960 R test condition because it uses carefully selected high temperature alloy materials such as Hastelloy-X. The lower plenum assembly was designed to operate at pressures to 450 psig at 1960 R, in accordance with the ASME B31.3 piping code. The natural gas-fueled combustor fires directly into the lower manifold. The hot air is directed through eight 1-1/2-in. supply pipes that supply the upper plenum. The flow is conditioned in the upper plenum prior to flowing to the research nozzle. The 1-1/2-in. supply lines are arranged in a U-shaped design to provide for a flexible piping system. The combustor assembly checkout was successfully conducted in Glenn's Engine Component Research Laboratory in the spring of 2001. The combustor is a low-smoke version of the J79 combustor used to power the F4 Phantom military aircraft. The natural gas-fueled combustor demonstrated high-efficiency combustion over a wide range of operating

  13. A Model of Graceful Exit in String Cosmology

    CERN Document Server

    Brustein, Ram; Brustein, Ram; Madden, Richard

    1998-01-01

    We construct, for the first time, a model of graceful exit transition from a dilaton-driven inflationary phase to a decelerated Friedman-Robertson-Walker era. Exploiting a demonstration that classical corrections can stabilize a high curvature string phase while the evolution is still in the weakly coupled regime, we show that if additional terms of the type that may result from quantum corrections to the string effective action exist, and induce violation of the null energy condition, then evolution towards a decelerated Friedman-Robertson-Walker phase is possible. We also observe that stabilizing the dilaton at a fixed value, either by capture in a potential minimum or by radiation production, may require that these quantum corrections are turned off, perhaps by non-perturbative effects or higher order contributions which overturn the null energy condition violation.

  14. Destruction and Reallocation of Skills Following Large Company Exit

    DEFF Research Database (Denmark)

    Holm, Jacob Rubæk; Østergaard, Christian Richter; Olesen, Thomas Roslyng

    then becomes: under which conditions are the redundant workers and their skills reallocated to productive use elsewhere in the regional economy and when do the workers find a job where their specific skills are less valuable to the new employer and the worker must start over acquiring new skills, that is......What happens to redundant skills and workers when a large company closes down in a region? The knowledge embodied in firms is lost when firms exit. However, the skills, competences and knowledge embodied in the displaced employees are suddenly released and can become channels of knowledge transfer...... for other firms that hire them. This process can be very disruptive. For instance, when a large, old and well-renowned company closes down displacing thousands of workers over a short period of time, then it may be a shock to the regional economy and lead to unemployment and skill destruction. The question...

  15. Destruction and Reallocation of Skills Following Large Company Exit

    DEFF Research Database (Denmark)

    Holm, Jacob Rubæk; Østergaard, Christian Richter; Roslyng Olesen, Thomas

    What happens to redundant skills and workers when a large company closes down in a region? The knowledge embodied in firms is lost when firms exit. However, the skills, competences and knowledge embodied in the displaced employees are suddenly released and can become channels of knowledge transfer...... for other firms that hire them. This process can be very disruptive. For instance, when a large, old and well-renowned company closes down displacing thousands of workers over a short period of time, then it may be a shock to the regional economy and lead to unemployment and skill destruction. The question...... then becomes: under which conditions are the redundant workers and their skills reallocated to productive use elsewhere in the regional economy and when do the workers find a job where their specific skills are less valuable to the new employer and the worker must start over acquiring new skills, that is...

  16. Modelling guidelines for core exit temperature simulations with system codes

    Energy Technology Data Exchange (ETDEWEB)

    Freixa, J., E-mail: jordi.freixa-terradas@upc.edu [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain); Paul Scherrer Institut (PSI), 5232 Villigen (Switzerland); Martínez-Quiroga, V., E-mail: victor.martinez@nortuen.com [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain); Zerkak, O., E-mail: omar.zerkak@psi.ch [Paul Scherrer Institut (PSI), 5232 Villigen (Switzerland); Reventós, F., E-mail: francesc.reventos@upc.edu [Department of Physics and Nuclear Engineering, Technical University of Catalonia (UPC) (Spain)

    2015-05-15

    Highlights: • Core exit temperature is used in PWRs as an indication of core heat up. • Modelling guidelines of CET response with system codes. • Modelling of heat transfer processes in the core and UP regions. - Abstract: Core exit temperature (CET) measurements play an important role in the sequence of actions under accidental conditions in pressurized water reactors (PWR). Given the difficulties in placing measurements in the core region, CET readings are used as criterion for the initiation of accident management (AM) procedures because they can indicate a core heat up scenario. However, the CET responses have some limitation in detecting inadequate core cooling and core uncovery simply because the measurement is not placed inside the core. Therefore, it is of main importance in the field of nuclear safety for PWR power plants to assess the capabilities of system codes for simulating the relation between the CET and the peak cladding temperature (PCT). The work presented in this paper intends to address this open question by making use of experimental work at integral test facilities (ITF) where experiments related to the evolution of the CET and the PCT during transient conditions have been carried out. In particular, simulations of two experiments performed at the ROSA/LSTF and PKL facilities are presented. The two experiments are part of a counterpart exercise between the OECD/NEA ROSA-2 and OECD/NEA PKL-2 projects. The simulations are used to derive guidelines in how to correctly reproduce the CET response during a core heat up scenario. Three aspects have been identified to be of main importance: (1) the need for a 3-dimensional representation of the core and Upper Plenum (UP) regions in order to model the heterogeneity of the power zones and axial areas, (2) the detailed representation of the active and passive heat structures, and (3) the use of simulated thermocouples instead of steam temperatures to represent the CET readings.

  17. Private Wealth and Job Exit at Older Age: a Random Effects Model

    OpenAIRE

    Bloemen, H.G.

    2008-01-01

    Forthcoming in 'Empirical Economics' . Private wealth holdings are likely to become an increasingly important determinant in the job exit decision of elderly workers. Net wealth may correlate with worker's characteristics that also determine the exit out of a job. It is therefore important to include a rich set of observed characteristics in an empirical model for retirement in order to measure the (marginal) effect of wealth on the job exit rate. But even with a rich set of regressors the qu...

  18. Farm growth and exit: consequences of EU dairy policy reform for Dutch dairy farming

    NARCIS (Netherlands)

    Peerlings, J.H.M.; Ooms, D.L.

    2008-01-01

    The purpose of this paper is to analyse farm growth and exit and its interaction in Dutch dairy farming as consequences of the 2003 CAP reform and 2008 CAP Health Check. Results indicate that the decision to exit dairy farming is largely determined by household characteristics as age and the size of

  19. Wives' Relative Wages, Husbands' Paid Work Hours, and Wives' Labor-Force Exit

    Science.gov (United States)

    Shafer, Emily Fitzgibbons

    2011-01-01

    Economic theories predict that women are more likely to exit the labor force if their partners' earnings are higher and if their own wage rate is lower. In this article, I use the National Longitudinal Survey of Youth (N = 2,254) and discrete-time event-history analysis to show that wives' relative wages are more predictive of their exit than are…

  20. Re-Examining Exit Exams: New Findings from the Education Longitudinal Study of 2002

    Science.gov (United States)

    Shuster, Kate

    2012-01-01

    Using the nationally representative, cohort-based data of the Education Longitudinal Study of 2002 (ELS:02), this study employs multiple regression to examine the effects of exit exams on student achievement and school completion. This study finds that exit exams as a whole do not have substantial effects on student achievement in mathematics,…

  1. Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells.

    Directory of Open Access Journals (Sweden)

    Kathleen A Estes

    2011-09-01

    Full Text Available The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a transmissible spore form. Here we show that N. parisii causes rearrangements of host actin inside intestinal cells as part of a novel parasite exit strategy. First, we show that N. parisii infection causes ectopic localization of the normally apical-restricted actin to the basolateral side of intestinal cells, where it often forms network-like structures. Soon after this actin relocalization, we find that gaps appear in the terminal web, a conserved cytoskeletal structure that could present a barrier to exit. Reducing actin expression creates terminal web gaps in the absence of infection, suggesting that infection-induced actin relocalization triggers gap formation. We show that terminal web gaps form at a distinct stage of infection, precisely timed to precede spore exit, and that all contagious animals exhibit gaps. Interestingly, we find that while perturbations in actin can create these gaps, actin is not required for infection progression or spore formation, but actin is required for spore exit. Finally, we show that despite large numbers of spores exiting intestinal cells, this exit does not cause cell lysis. These results provide insight into parasite manipulation of the host cytoskeleton and non-lytic escape from intestinal cells in vivo.

  2. Efficiency, Leverage and Exit: The Role of Information Asymmetry in Concentrated Industries

    DEFF Research Database (Denmark)

    Siyahhan, Baran

    This paper develops a real options model of imperfect competition with asymmetric information that analyzes firms’ exit decisions. Optimal exit decision is linked to firm characteristics such as financial leverage and efficiency. The model shows that informational asymmetries can lead more...

  3. Efficiency, Leverage and Exit: The Role of Information Asymmetry in Concentrated Industries

    DEFF Research Database (Denmark)

    Siyahhan, Baran

    2011-01-01

    This paper develops a real options model of imperfect competition with asymmetric information that analyzes firms’ exit decisions. Optimal exit decision is linked to firm characteristics such as financial leverage and efficiency. The model shows that informational asymmetries can lead more...

  4. The EXIT for Prenatally Diagnosed Cervical Cystic Teratoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Sabri Cansaran

    2015-03-01

    Full Text Available The Ex-utero intrapartum treatment (EXIT is a procedure performed during caesarean section while on fetal-placental circulation. We present a prenatally diagnosed cervical cystic mass causing tracheal compression which was managed successfully with the EXIT procedure.

  5. Visual Barriers to Prevent Ambulatory ALzheimer's Patients from Exiting through an Emergency Door.

    Science.gov (United States)

    Namazi, Kevan H.; And Others

    1989-01-01

    Conducted study on Alzheimer's unit to test seven different visual barrier conditions for reducing patient exits. Findings indicated that exiting was eliminated under two conditions. Results suggest visual agnosia, the inability to interpret what the eye sees, may be used as tool in managing wandering behavior of Alzheimer's patients. (Author/NB)

  6. 36 CFR 13.1312 - Climbing and walking on Exit Glacier.

    Science.gov (United States)

    2010-07-01

    ... Glacier. 13.1312 Section 13.1312 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF... General Provisions § 13.1312 Climbing and walking on Exit Glacier. Except for areas designated by the Superintendent, climbing or walking on, in, or under Exit Glacier is prohibited within 1/2 mile of the...

  7. A methodology for evacuation route planning inside buildings using geospatial technology

    OpenAIRE

    Ramón Morte, Alfredo; Rodríguez Hidalgo, A.B.; Navarro Carrión, José Tomás; Zaragozí Zaragozí, Benito Manuel

    2013-01-01

    Evacuation route planning is a fundamental task for building engineering projects. Safety regulations are established so that all occupants are driven on time out of a building to a secure place when faced with an emergency situation. As an example, Spanish building code requires the planning of evacuation routes on large and, usually, public buildings. Engineers often plan these routes on single building projects, repeatedly assigning clusters of rooms to each emergency exit in a trial-and-e...

  8. Compact Fixed-exit UHV DCM for XAFS

    Science.gov (United States)

    Rickers, K.; Brüggmann, U.; Drube, W.; Herrmann, M.; Heuer, J.; Welter, E.; Schulte-Schrepping, H.; Schulz-Ritter, H.

    2007-01-01

    A double-crystal, UHV-compatible monochromator for XAFS applications at bending magnet beamlines has been designed. It uses two crystal sets, Si(111) and (311), on a common central rotation axis driven by an ex-vacuo goniometer. All mechanical and electrical components are mounted on a 400 mm UHV flange which is attached to a compact vacuum chamber. The first crystals are water cooled using connector- and bellowless tubing through the fluidic sealed feedthrough of the central rotation. The first crystal set is mounted off-axis and can be translated vertically to keep the fixed exit condition. The second crystal set uses small crystals of the same size as the first. In order to accept the reflected beam of the first crystal at small Bragg angles, it is tangentially translated along the beam. The angle can be varied from 5° to 55.5° resulting in a total energy range 2.4 - 43.4 keV for Si(111)/(311). Crystal sets are interchangeable by translating the vacuum chamber. Angle encoding is achieved by a Renishaw incremental optical encoder in vacuo.

  9. Core compressor exit stage study. 1: Aerodynamic and mechanical design

    Science.gov (United States)

    Burdsall, E. A.; Canal, E., Jr.; Lyons, K. A.

    1979-01-01

    The effect of aspect ratio on the performance of core compressor exit stages was demonstrated using two three stage, highly loaded, core compressors. Aspect ratio was identified as having a strong influence on compressors endwall loss. Both compressors simulated the last three stages of an advanced eight stage core compressor and were designed with the same 0.915 hub/tip ratio, 4.30 kg/sec (9.47 1bm/sec) inlet corrected flow, and 167 m/sec (547 ft/sec) corrected mean wheel speed. The first compressor had an aspect ratio of 0.81 and an overall pressure ratio of 1.357 at a design adiabatic efficiency of 88.3% with an average diffusion factor or 0.529. The aspect ratio of the second compressor was 1.22 with an overall pressure ratio of 1.324 at a design adiabatic efficiency of 88.7% with an average diffusion factor of 0.491.

  10. OPERATORS ON CORNER MANIFOLDS WITH EXIT TO INFINITY

    Institute of Scientific and Technical Information of China (English)

    D. Calvo; B. W. Schulze

    2006-01-01

    We study (pseudo-)differential operators on a manifold with edge Z,locally modelled on a wedge with model cone that has itself a base manifold W with smooth edge Y. The typical operators A are corner degenerate in a specific way. They (σψ (A), σ∧ (A), σ∧ (A)), where σψ is the interior symbol and σ∧ (A)(y, η), (y, η) ∈ T*Y\\0,weighted Sobolev spaces on the infinite cone with base W. Since such a cone has edges with exit to infinity, the calculus has the problem to understand the behaviour of operators on a manifold of that kind.We show the continuity of corner-degenerate operators in weighted edge Sobolev spaces, and we investigate the ellipticity of edge symbols of second generation. Starting from parameter-dependent elliptic families of edge operators of first generation, we obtain the Fredholm property of higher edge symbols on the corresponding singular infinite model cone.

  11. Exit Noise Summer Fest: Explaining the audience in ethnographic discourse

    Directory of Open Access Journals (Sweden)

    Lukić-Krstanović Miroslava M.

    2005-01-01

    Full Text Available In Ethnology, studying festivals is a relevant activity since it could enlighten a number of complex cultural and social processes. The festivals represent public events, public ceremonies, cluster of rituals and produce many symbols, and as such, they are in fact a creative reflection of a society. In this paper, we analyze the Exit Noise Summer Fest, the biggest music festival in SE Europe. The aim of the analysis is to gain understanding of the cultural event of this kind and its protagonists, namely, the audience. Shedding a light to a music spectacle, from a standpoint of social and symbolic communication, directs to a different perspective in reading of rituals, communities zones, and semantic constructions of noise and body in the center of ritual behaviors. The research shows that the music experience and atmosphere of the celebration, though having somewhat unclear ritual borderline and zone, are compatible with the daily culture and social processes, in which the event is created and further reflects itself through various mediums.

  12. Exiting Lepušićeva: Discussion

    Directory of Open Access Journals (Sweden)

    Danijela Dolenec

    2014-04-01

    Full Text Available In the article “Exiting Lepušićeva?” Kasapović engages once again with the very important issue of critical evaluation of the development of political science in Croatia, with a particular focus on the status of comparative politics within the discipline. The author takes an outside perspective in the approach to the analysis of the reasons why Croatia can rarely be found in international comparative studies, and inquires into the reasons why political scientists abroad, involved in large-scale international research programs, rarely include Croatia as one of their case studies? In addition to Kasapović’s argument, I begin by summing up the main problems, and afterwards I argue that the development of empirical political science in Croatia takes place in the absence of a comprehensive Science and research policy on the national level, but also in the context of insufficient concern of the scientists themselves for the conditions of knowledge production and the mechanisms of reproduction of the discipline.

  13. Optimization of exit pupil function: improvement on the OTF of full parallax holographic stereograms

    International Nuclear Information System (INIS)

    The wavefront reconstructed errors of full parallax holographic stereograms are analysed. The optical transfer function (OTF) is simulated to investigate frequency response and imaging quality of holographic stereogram systems. The behaviour of the OTF with respect to slit size and spatial frequency in different aberrations is described and used to optimize the exit pupil function. The shaped window function (Gaussian and Blackman) is proposed to be used as the exit pupil function of holographic systems, and the influence of different exit pupil functions on the OTF is investigated in detail. The calculated results show that the shaped exit pupil function with optimized slit size can improve the imaging quality of full parallax holographic stereogram systems effectively. The design criterion of the exit pupil function is also discussed. (paper)

  14. GUTKA-A MALIGNANT ENTITY SEEKS BENIGN EXIT IN INDIA

    Directory of Open Access Journals (Sweden)

    Kharat

    2013-01-01

    Full Text Available ABSTRACT: Tobacco and its products have been a household entit y since a long time specially in Indian houses either as a pride to be snuffed thr ough the pipes or the traditional hookahs by the rajas maharajas, or if not through the smoke it took place in many untowardly customs and rituals associated. It has spread through the subcon tinent, and even to the other countries. Promoted by a slick and many- tentacled advertising campaign, gutka, an indigenous form of smokeless tobacco, has become a fixture in the mout hs of millions of Indians over the last two decades. But what has prompted particular concern her e is the way that in the last 10 years, gutka as portable as chewing gum and sometimes as sw eet as candy has found its way into the mouths of Indian children. Out of fad and style quo tient, it made its way in exchange of mere money in pockets of many turning into one of the maj or concerns for health problems particularly in India. Various social workers and he alth professionals have urged for ban of tobacco products, especially the gutka as it is the n eed of the hour to stop chewing to avoid future regret of oral health. In that context, gove rnment too is starting a ban of sale and supply of such products considering the youth in terms of its addiction and child labour associated. However, with the increasing awareness regarding it s pros and cons, alarming many of this fad, it’s slowly and gradually making its way to exit to create smiles with disease and addiction free life to man

  15. Exit Survey of Senior Residents: Cost Conscious but Uninformed.

    Science.gov (United States)

    Long, Theodore; Silvestri, Mark T; Dashevsky, Meir; Halim, Andrea; Fogerty, Robert L

    2016-05-01

    Background Cost awareness, to ensure physician stewardship of limited resources, is increasingly recognized as an important skill for physicians. The Accreditation Council for Graduate Medical Education has made cost awareness part of systems-based practice, a core competency of resident education. However, little is known about resident cost awareness. Objective We sought to assess senior resident self-perceived cost awareness and cost knowledge. Methods In March 2014, we conducted a cross-sectional survey of all emergency medicine, internal medicine, obstetrics and gynecology, orthopaedic surgery pediatrics, and medicine-pediatrics residents in their final year at Yale-New Haven Hospital. The survey examined attitudes toward health care costs and residents' estimates of order prices. We considered resident price estimates to be accurate if they were between 50% and 200% of the Connecticut-specific Medicare price. Results We sent the survey to 84 residents and received 47 completed surveys (56% response rate). Although more than 95% (45 of 47) felt that containing costs is the responsibility of every clinician, and 49% (23 of 47) agreed that cost influenced their decision when ordering, only 4% (2 of 47) agreed that they knew the cost of tests being ordered. No residents accurately estimated the price of a complete blood count with differential, and only 2.1% (1 of 47) were accurate for a basic metabolic panel. The overall accuracy of all resident responses was 25%. Conclusions In our study, many trainees exit residency with self-identified deficiencies in knowledge about costs. The findings show the need for educational approaches to improve cost awareness among trainees. PMID:27168897

  16. Transgenic C. elegans dauer larvae expressing hookworm phospho null DAF-16/FoxO exit dauer.

    Directory of Open Access Journals (Sweden)

    Verena Gelmedin

    Full Text Available Parasitic hookworms and the free-living model nematode Caenorhabtidis elegans share a developmental arrested stage, called the dauer stage in C. elegans and the infective third-stage larva (L3 in hookworms. One of the key transcription factors that regulate entrance to and exit from developmental arrest is the forkhead transcription factor DAF-16/FoxO. During the dauer stage, DAF-16 is activated and localized in the nucleus. DAF-16 is negatively regulated by phosphorylation by the upstream kinase AKT, which causes DAF-16 to localize out of the nucleus and the worm to exit from dauer. DAF-16 is conserved in hookworms, and hypothesized to control recovery from L3 arrest during infection. Lacking reverse genetic techniques for use in hookworms, we used C. elegans complementation assays to investigate the function of Ancylostoma caninum DAF-16 during entrance and exit from L3 developmental arrest. We performed dauer switching assays and observed the restoration of the dauer phenotype when Ac-DAF-16 was expressed in temperature-sensitive dauer defective C. elegans daf-2(e1370;daf-16(mu86 mutants. AKT phosphorylation site mutants of Ac-DAF-16 were also able to restore the dauer phenotype, but surprisingly allowed dauer exit when temperatures were lowered. We used fluorescence microscopy to localize DAF-16 during dauer and exit from dauer in C. elegans DAF-16 mutant worms expressing Ac-DAF-16, and found that Ac-DAF-16 exited the nucleus during dauer exit. Surprisingly, Ac-DAF-16 with mutated AKT phosphorylation sites also exited the nucleus during dauer exit. Our results suggest that another mechanism may be involved in the regulation DAF-16 nuclear localization during recovery from developmental arrest.

  17. Assessment Drives Learning: The Effect of Central Exit Exams on Curricular Knowledge and Mathematical Literacy

    OpenAIRE

    Jürges, Hendrik; Schneider, Kerstin; Senkbeil, Martin; Claus H. Carstensen

    2009-01-01

    In this paper, we use data from the German PISA 2003 sample to study the effects of central exit examinations on student performance, student attitudes, and teacher behavior. Unlike earlier studies we use (i) a value-added measure to pin down the effect of central exit exams on learning in the last year before the exam and (ii) separate test scores for mathematical literacy and curriculum-based knowledge. The findings indicate that central exit exams only improve curriculum-based knowledge bu...

  18. Static performance of an axisymmetric nozzle with post-exit vanes for multiaxis thrust vectoring

    Science.gov (United States)

    Berrier, Bobby L.; Mason, Mary L.

    1988-01-01

    An investigation was conducted in the static test facility of the Langley 16-Foot Transonic Tunnel to determine the flow-turning capability and the nozzle internal performance of an axisymmetric convergent-divergent nozzle with post-exit vanes installed for multiaxis thrust vectoring. The effects of vane curvature, vane location relative to the nozzle exit, number of vanes, and vane deflection angle were determined. A comparison of the post-exit-vane thrust-vectoring concept with other thrust-vectoring concepts is provided. All tests were conducted with no external flow, and nozzle pressure ratio was varied from 1.6 to 6.0.

  19. Jet engine nozzle exit configurations, including projections oriented relative to pylons, and associated systems and methods

    Science.gov (United States)

    Mengle, Vinod G. (Inventor); Thomas, Russell H. (Inventor)

    2012-01-01

    Nozzle exit configurations and associated systems and methods are disclosed. An aircraft system in accordance with one embodiment includes a jet engine exhaust nozzle having an internal flow surface and an exit aperture, with the exit aperture having a perimeter that includes multiple projections extending in an aft direction. Aft portions of individual neighboring projections are spaced apart from each other by a gap, and a geometric feature of the multiple can change in a monotonic manner along at least a portion of the perimeter. Projections near a support pylon and/or associated heat shield can have particular configurations, including greater flow immersion than other projections.

  20. Market entry and exit by biotech and device companies funded by venture capital.

    Science.gov (United States)

    Burns, Lawton R; Housman, Michael G; Robinson, Charles A

    2009-01-01

    Start-up companies in the biotechnology and medical device sectors are important sources of health care innovation. This paper describes the role of venture capital in supporting these companies and charts the growth in venture capital financial support. The paper then uses longitudinal data to describe market entry and exit by these companies. Similar factors are associated with entry and exit in the two sectors. Entries and exits in one sector also appear to influence entry in the other. These findings have important implications for developing innovative technologies and ensuring competitive markets in the life sciences.

  1. Can exit prizes induce lame ducks to shirk less? Experimental evidence

    Directory of Open Access Journals (Sweden)

    Leif Helland

    2012-12-01

    Full Text Available Elected representatives serving their final period face only weak incentives to provide costly effort. However, overlapping generations (OLG models suggest that exit prizes sustained by trigger strategies can induce representatives in their final period to provide such effort. We evaluate this hypothesis using a simple OLG public good experiment, the central treatment being whether exit prizes are permitted. We find that a significantly higher number of subjects in their final period contribute when exit prizes are permitted. However, this result does not originate from use of trigger strategies. More likely explanations include gift-exchange and focal-point effects.

  2. Mean Exit Time and Escape Probability for a Tumor Growth System under Non-Gaussian Noise

    CERN Document Server

    Ren, Jian; Gao, Ting; Kan, Xingye; Duan, Jinqiao

    2011-01-01

    Effects of non-Gaussian $\\alpha-$stable L\\'evy noise on the Gompertz tumor growth model are quantified by considering the mean exit time and escape probability of the cancer cell density from inside a safe or benign domain. The mean exit time and escape probability problems are formulated in a differential-integral equation with a fractional Laplacian operator. Numerical simulations are conducted to evaluate how the mean exit time and escape probability vary or bifurcates when $\\alpha$ changes. Some bifurcation phenomena are observed and their impacts are discussed.

  3. Optimum design of exit guide vane on the bidirectional tubular turbine

    International Nuclear Information System (INIS)

    Performance prediction about the forward generation condition based on a bidirectional through-flow turbine runner was conducted. The model characteristic curves and efficiency curve under reverse generation condition were plotted. In order to improve the reverse performance, exit guide vanes were lied behind the runner, the forward and reverse operating performance about a runner lied post-guide vane were numerically simulated. The results shows that the flow field distribution on forward generation condition did not significantly change after exit guide vanes were lied, and the energy conversion efficiency decreased. After exit guide vanes were lied, flow pattern of runner intake on under reverse generation condition were bettered, and the energy conversion efficiency increased. This study confirms that the exit guide vanes can improve the hydraulic performance of the turbine on reverse generation condition in view of numerical simulation

  4. Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.

    Science.gov (United States)

    Famulski, Jakub K; Trivedi, Niraj; Howell, Danielle; Yang, Yuan; Tong, Yiai; Gilbertson, Richard; Solecki, David J

    2010-12-24

    The brain's circuitry is established by directed migration and synaptogenesis of neurons during development. Although neurons mature and migrate in specific patterns, little is known about how neurons exit their germinal zone niche. We found that cerebellar granule neuron germinal zone exit is regulated by proteasomal degradation of Pard3A by the Seven in Absentia homolog (Siah) E3 ubiquitin ligase. Pard3A gain of function and Siah loss of function induce precocious radial migration. Time-lapse imaging using a probe to measure neuronal cell contact reveals that Pard3A promotes adhesive interactions needed for germinal zone exit by recruiting the epithelial tight junction adhesion molecule C to the neuronal cell surface. Our findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche.

  5. Quantitative Analysis of Zero and High Order Laue Zones Effects on the Exit Wave Function

    Institute of Scientific and Technical Information of China (English)

    Canying CAI; Qibin YANG; Hongrong LIU; Yanguo WANG

    2004-01-01

    The exit wave function including zero and high order Laue zones has been simulated by both multi-slice method and electron dynamic diffraction analytical expression. Coincidence of the simulations by these two methods was achieved. The calculated results showed that the exit wave function highly dominated by zero order Laue zone,while high order ones modify the exit wave function to some extent depending on the situation. High order Laue zone effects become important for the following cases: sample consists of light elements, the thickness is very thin,lattice planar spacing perpendicular to the direction of the incident beam is large, and the electron beam has long wavelength. In these cases the exit wave function should be corrected by adding high order Laue zone effects. The analytical expression is effective and convenient for dealing with high order Laue zone effects.

  6. Do High School Exit Exams Influence Educational Attainment or Labor Market Performance?

    OpenAIRE

    Thomas S. Dee; Brian A. Jacob

    2006-01-01

    State requirements that high school graduates pass exit exams were the leading edge of the movement towards standards-based reform and continue to be adopted and refined by states today. In this study, we present new empirical evidence on how exit exams influenced educational attainment and labor market experiences using data from the 2000 Census and the National Center for Education Statistics' Common Core of Data (CCD). Our results suggest that the effects of these reforms have been heterog...

  7. Exit-beskatning af selskaber og det EU-retlige proportionalitetsprincip

    DEFF Research Database (Denmark)

    Poulsen, Martin

    2011-01-01

    EU-Domstolen har afsagt dom i den nederlandske sag National Grid Indus om exit-beskatning af selskaber. Dommen må forventes at medføre, at en række lande, herunder Danmark, vil være forpligtet til at ændre nugældende regler om exit-beskatning. Artiklen foretager i den forbindelse en analyse af de...

  8. Can exit prizes induce lame ducks to shirk less? Experimental evidence

    OpenAIRE

    Leif Helland; Jon Hovi; Lars Monkerud

    2012-01-01

    Elected representatives serving their final period face only weak incentives to provide costly effort. However, overlapping generations (OLG) models suggest that exit prizes sustained by trigger strategies can induce representatives in their final period to provide such effort. We evaluate this hypothesis using a simple OLG public good experiment, the central treatment being whether exit prizes are permitted. We find that a significantly higher number of subjects in their final...

  9. Modeling Exit and Entry of Farmers in a Crop Insurance Program

    OpenAIRE

    Cabas, Juan H.; Leiva, Akssell J.; Weersink, Alfons

    2008-01-01

    This paper examines the factors influencing farmer participation in crop insurance schemes, but unlike previous studies that focus on total demand, participation is disaggregated into entrants and those exiting. Modeling entry and exit decisions separately illustrates that the effect of a given variable is often muted by aggregation. In addition, the approach in this paper distinguishes between price and yield variables rather than total returns and is consequently able to demonstrate that pr...

  10. The Effect of Central Exit Examinations on Student Achievement: Quasi-experimental Evidence from TIMSS Germany

    OpenAIRE

    Jürges, Hendrik; Schneider, Kerstin; Büchel, Felix

    2003-01-01

    This paper makes use of the regional variation in schooling legislation within the German secondary education system to estimate the causal effect of central exit examinations on student performance. We propose a difference-in-differences framework that exploits the quasi-experimental nature of the German TIMSS middle-school sample. The estimates show that students in federal states with central exit examinations clearly outperform students in other federal states, but that only part of the d...

  11. IR signature study of aircraft engine for variation in nozzle exit area

    Science.gov (United States)

    Baranwal, Nidhi; Mahulikar, Shripad P.

    2016-01-01

    In general, jet engines operate with choked nozzle during take-off, climb and cruise, whereas unchoking occurs while landing and taxiing (when engine is not running at full power). Appropriate thrust in an aircraft in all stages of the flight, i.e., take-off, climb, cruise, descent and landing is achieved through variation in the nozzle exit area. This paper describes the effect on thrust and IR radiance of a turbojet engine due to variation in the exit area of a just choked converging nozzle (Me = 1). The variations in the nozzle exit area result in either choking or unchoking of a just choked converging nozzle. Results for the change in nozzle exit area are analyzed in terms of thrust, mass flow rate and specific fuel consumption. The solid angle subtended (Ω) by the exhaust system is estimated analytically, for the variation in nozzle exit area (Ane), as it affects the visibility of the hot engine parts from the rear aspect. For constant design point thrust, IR radiance is studied from the boresight (ϕ = 0°, directly from the rear side) for various percentage changes in nozzle exit area (%ΔAne), in the 1.9-2.9 μm and 3-5 μm bands.

  12. Experiment of cavitation erosion at the exit of a long orifice

    International Nuclear Information System (INIS)

    We performed experiments to clarify mechanism of cavitation erosion and to predict cavitation erosion rate at the exit of a long orifice equipped at the chemical and volume control system in a pressurized water reactor (PWR). In order to find this mechanism, we used a high speed video camera. As the result, we observed bubble collapses near the exit of the orifice when flow condition was oscillating. So the bubble collapses due to the oscillation might cause the first stage erosion at the exit of the orifice. Using the orifice which had the cone-shaped exit, we observed that bubbles collapsed near the exit and then they collapsed at the upstream like a chain reaction. So this bubble collapse mechanism could be explained as follows: shock wave was generated by the bubble collapse near the exit, then it propagated upwards, consequently it caused the bubble collapse at the upstream. And we predicted erosion rate by evaluating the effect of the velocity and comparing the erosion resistance between the test speciment (aluminum) and the plant material (stainless steel) by means of vibratory tests. We compared the predicted erosion rate with that of the average value estimated from plant investigation, then we examined the applicability of these method to the plant evaluations. (author)

  13. CFD simulation of smooth and T-abrupt exits in circulating fluidized bed risers

    Institute of Scientific and Technical Information of China (English)

    Xuezhi Wu; Fan Jiang; Xiang Xu; Yunhan Xiao

    2010-01-01

    Gas-solid flow in circulating fluidized bed(CFB)risers depends not only on operating conditions but also on exit configurations.Few studies investigated the effects of exit configurations on flow structure using computational fluid dynamics(CFD).This paper provides a 2D two-fluid model to simulate a cold bench-scale square cross-section riser with smooth and T-abrupt exits.The drag force between the gas and solid phases plays an important role in CFD.Since the drag force model based on homogeneous twophase flow,such as the Wen-Yu correlation,could not capture the heterogeneous structures in gas-solid flow,the structure-dependent energy-minimization multi-scale(EMMS)drag force model(Wang.Ge,&Li,2008),applicable for Geldart B particles(sand),was integrated into the two-fluid model.The calculated axial solids hold-up profiles were respectively exponential curve for smooth exit and C-shaped curve for T-abrupt exit,both consistent with experimental data.This study once again proves the key role of drag force in CFD simulation and also shows the validity of CFD simulation(two-fluid model)to describe exit effects on gas-solid flow in CFB risers.

  14. Numerical analysis of two and three dimensional buoyancy driven water-exit of a circular cylinder

    Directory of Open Access Journals (Sweden)

    Moshari Shahab

    2014-06-01

    Full Text Available With the development of the technology of underwater moving bodies, the need for developing the knowledge of surface effect interaction of free surface and underwater moving bodies is increased. Hence, the two-phase flow is a subject which is interesting for many researchers all around the world. In this paper, the non-linear free surface deformations which occur during the water-exit of a circular cylinder due to its buoyancy are solved using finite volume discretization based code, and using Volume of Fluid (VOF scheme for solving two phase flow. Dynamic mesh model is used to simulate dynamic motion of the cylinder. In addition, the effect of cylinder mass in presence of an external force is studied. Moreover, the oblique exit and entry of a circular cylinder with two exit angles is simulated. At last, water-exit of a circular cylinder in six degrees of freedom is simulated in 3D using parallel processing. The simulation errors of present work (using VOF method for maximum velocity and height of a circular cylinder are less than the corresponding errors of level set method reported by previous researchers. Oblique exit shows interesting results; formation of waves caused by exit of the cylinder, wave motion in horizontal direction and the air trapped between the waves are observable. In 3D simulation the visualization of water motion on the top surface of the cylinder and the free surface breaking on the front and back faces of the 3D cylinder at the exit phase are observed which cannot be seen in 2D simulation. Comparing the results, 3D simulation shows better agreement with experimental data, specially in the maximum height position of the cylinder.

  15. Reactor building

    International Nuclear Information System (INIS)

    The whole reactor building is accommodated in a shaft and is sealed level with the earth's surface by a building ceiling, which provides protection against penetration due to external effects. The building ceiling is supported on walls of the reactor building, which line the shaft and transfer the vertical components of forces to the foundations. The thickness of the walls is designed to withstand horizontal pressure waves in the floor. The building ceiling has an opening above the reactor, which must be closed by cover plates. Operating equipment for the reactor can be situated above the building ceiling. (orig./HP)

  16. Exit from sliding in piecewise-smooth flows: Deterministic vs. determinacy-breaking.

    Science.gov (United States)

    Jeffrey, Mike R

    2016-03-01

    The collapse of flows onto hypersurfaces where their vector fields are discontinuous creates highly robust states called sliding modes. The way flows exit from such sliding modes can lead to complex and interesting behaviour about which little is currently known. Here, we examine the basic mechanisms by which a flow exits from sliding, either along a switching surface or along the intersection of two switching surfaces, with a view to understanding sliding and exit when many switches are involved. On a single switching surface, exit occurs via tangency of the flow to the switching surface. Along an intersection of switches, exit can occur at a tangency with a lower codimension sliding flow, or by a spiralling of the flow that exhibits geometric divergence (infinite steps in finite time). Determinacy-breaking can occur where a singularity creates a set-valued flow in an otherwise deterministic system, and we resolve such dynamics as far as possible by blowing up the switching surface into a switching layer. We show preliminary simulations exploring the role of determinacy-breaking events as organizing centres of local and global dynamics. PMID:27036186

  17. Effects of the geometric orientations of the nozzle exit on the breakup of free liquid jet

    Energy Technology Data Exchange (ETDEWEB)

    Lad, V. N.; Murthy, Z. V. P. [Sardar Vallabhbhai National Institute of Technology, Gujarat (India)

    2016-04-15

    Free liquid jets are produced through various geometric orientations of the nozzle exit. The breakup lengths of liquid jets under various geometric orientations of the nozzle exit were studied. Images of jets were captured using a high-speed camera with a maximum frame rate of 1000 frames per second and were analyzed to determine the dynamics between jets and breakup lengths. The breakup length of jets changes with the cut angle of the nozzle exit. In addition, adding polymer reduces the effect of the cut angle of the nozzle exit on the breakup length for an entire range of velocities. The effect of the cut angle on breakup length is predominant for aqueous solutions with surfactants. This work provides motivation for further computational research to study jet dynamics in a partially covered nozzle exit, such as the case in which the boundary conditions near the nozzle opening is more complex with the cut angle and its vertex position, which directly reflects liquid jet dynamics.

  18. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    IBACOS researched the constructability and viability issues of using high performance windows as one component of a larger approach to building houses that achieve the Building America 70% energy savings target.

  19. Solar building

    OpenAIRE

    Zhang, Luxin

    2014-01-01

    In my thesis I describe the utilization of solar energy and solar energy with building integration. In introduction it is also mentioned how the solar building works, trying to make more people understand and accept the solar building. The thesis introduces different types of solar heat collectors. I compared the difference two operation modes of solar water heating system and created examples of solar water system selection. I also introduced other solar building applications. It is conv...

  20. Experimental research and numerical simulation on impeller exit flow field of bulb tubular pump

    International Nuclear Information System (INIS)

    Three dimensional Laser Doppler Velocimetry (3D-LDV) technique was used to measure the impeller exit flow field of bulb tubular pump, the average velocity distribution of the exit section was obtained, and the energy performance of bulb tubular pump was obtained by model test. The flow field of tubular pump also simulated by CFD based on Navier-Stokes equations and RNG k-ε model. The calculated performance curve was consistent with the model test results, and the calculated velocities of impeller exit compared with the LDV measurement results, it was shown that the distribution of circumferential velocity and axial velocity were close to each other, but the radial velocity deviation between the LDV results and the CFD ones was obviously, the reasons of deviation were analyzed. The experimental results can provide the references for the impeller and diffuser design of tubular pumps, it also can improve the accuracy of calculation and perfect simulation.

  1. Peritonitis and catheter exit-site infection in patients on peritoneal dialysis at home1

    Science.gov (United States)

    Abud, Ana Cristina Freire; Kusumota, Luciana; dos Santos, Manoel Antônio; Rodrigues, Flávia Fernanda Luchetti; Damasceno, Marta Maria Coelho; Zanetti, Maria Lúcia

    2015-01-01

    Objective: to analyze the complications related to peritonitis and catheter exit-site infections, in patients on peritoneal dialysis at home. Method: quantitative and cross-sectional study, carried out with 90 patients on peritoneal dialysis at home, in a municipality in the Northeast region of Brazil. For data collection, it was used two structured scripts and consultation on medical records. Descriptive analysis and comparison tests among independent groups were used, considering p<0.05 as level of statistical significance. Results: by comparing the frequency of peritonitis and the length of treatment, it was found that patients over two years of peritoneal dialysis were more likely to develop peritonitis (X²=6.39; p=0.01). The number of episodes of peritoneal catheter exit-site infection showed association with the length of treatment (U=224,000; p=0.015). Conclusion: peritonitis and catheter exit-site infection are associated with the length of treatment. PMID:26487141

  2. Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit.

    Directory of Open Access Journals (Sweden)

    Phing Chian Chai

    Full Text Available In Drosophila postembryonic neuroblasts, transition in gene expression programs of a cascade of transcription factors (also known as the temporal series acts together with the asymmetric division machinery to generate diverse neurons with distinct identities and regulate the end of neuroblast proliferation. However, the underlying mechanism of how this "temporal series" acts during development remains unclear. Here, we show that Hh signaling in the postembryonic brain is temporally regulated; excess (earlier onset of Hh signaling causes premature neuroblast cell cycle exit and under-proliferation, whereas loss of Hh signaling causes delayed cell cycle exit and excess proliferation. Moreover, the Hh pathway functions downstream of Castor but upstream of Grainyhead, two components of the temporal series, to schedule neuroblast cell cycle exit. Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis.

  3. The use of an electronic portal imaging device for exit dosimetry and quality control measurements

    International Nuclear Information System (INIS)

    Purpose: To determine ways in which electronic portal imaging devices (EPIDs) could be used to (a) measure exit doses for external beam radiotherapy and (b) perform quality control checks on linear accelerators. Methods and Materials: When imaging, our fluoroscopic EPID adjusts the gain, offset, and frame acquisition time of the charge coupled device (CCD) camera automatically, to allow for the range of photon transmissions through the patient, and to optimize the signal-to-noise ratio. However, our EPID can be programmed to act as an integrating dosemeter. EPID dosemeter measurements were made for 20 MV photons, for different field sizes and thicknesses of unit density phantom material placed at varying exit surface to detector distances. These were compared with simultaneous Silicon diode exit dose measurements. Our exit dosimetry technique was verified using an anthropomorphic type phantom, and some initial measurements have been made for patients treated with irregularly shaped 20 MV x-ray fields. In this dosimetry mode, our EPID was also used to measure certain quality control parameters, x-ray field flatness, and the verification of segmented intensity modulated field prescriptions. Results: Configured for dosimetry, our EPID exhibited a highly linear response, capable of resolving individual monitor units. Exit doses could be measured to within about 3% of that measured using Silicon diodes. Field flatness was determined to within 1.5% of Farmer dosemeter measurements. Segmented intensity modulated fields can be easily verified. Conclusions: Our EPID has the versatility to assess a range of parameters pertinent to the delivery of high quality, high precision radiotherapy. When configured appropriately, it can measure exit doses in vivo, with reasonable accuracy, perform certain quick quality control checks, and analyze segmented intensity modulated treatment fields

  4. EFFECT OF REVENUE INSURANCE ON ENTRY AND EXIT DECISIONS IN TABLE GRAPE PRODUCTION: A REAL OPTION APPROACH

    OpenAIRE

    Seo, Sangtaek; Salin, Victoria; Paul D Mitchell; Leatham, David J.

    2004-01-01

    This study determines the entry and exit thresholds of table grape farming with irreversible investment under uncertainty. Real option approach is adopted to consider the investment and management flexibility. Also revenue insurance is introduced to consider the effect of the risk management programs on the entry and exit thresholds. Results show that revenue insurance increases the entry and exit thresholds by 1% and 4%, respectively, thus discouraging new investment and current farming, as ...

  5. Fast Water Transport in CNTs: length dependence and entrane/exit effects

    DEFF Research Database (Denmark)

    Walther, Jens Honore; Koumoutsakos, Petros

    , for the first time, that under imposed pressures of the order of 1 bar, water entry into the CNT cavity and exit from the CNT end, can occur only on pre-wetted membranes. We conduct large scale simulations for up to 500nm long CNTs and observe a previously unseen dependence of the flow enhancement rates......Superfast water transport in carbon nanotube (CNT) membranes has been reported in experimental studies. We use Molecular Dynamics simulations to elucidate the mechanisms of water entry, exit and transport in 2nm-diameter hydrophobic CNTs embedded in a hydrophilic membrane matrix. We demonstrate...

  6. Distinction between entrance and exit wounds by energy dispersive X-ray fluorescence spectrometry.

    Science.gov (United States)

    Tanaka, Naoko; Kinoshita, Hiroshi; Takakura, Ayaka; Jamal, Mostofa; Ito, Asuka; Kumihashi, Mitsuru; Tsutsui, Kunihiko; Kimura, Shoji; Ameno, Kiyoshi

    2016-09-01

    We investigated gunshot wounds in two autopsy cases using energy dispersive X-ray spectrometry (EDX). Lead and copper were detected in the entrance wound of one case and lead, antimony, and copper were detected in that of the other case. In the exit wounds of both cases, lead, antimony, and copper were below detection limits. These findings indicate that the detection of metallic elements, such as lead, antimony, and copper, which are found in bullets, may be useful for differentiating entrance from exit wounds using EDX. PMID:27591531

  7. Investigations in the degradation of polar and non-polar exit air constituents in biological scrubbers

    International Nuclear Information System (INIS)

    On a semi-technical scale (exit air volume flows between 1000 m3.h-1 and 3600 m3.h-1), experiments in the treatment of exit air from a mixed production plant of the chemical industry by biological absorption process were carried through. During testing, the configuration of the pilot plant was changed. Thus, both a multiple-zone nozzle scrubber and a packed column were used as an absorber, and as a scrubbing liquid both aerated sludge and a dispersion of aerated sludge and silicon oil with silicon oil contents of up to 5% wer used. (orig.)

  8. Plasma arc welding torch having means for vortexing plasma gas exiting the welding torch

    Science.gov (United States)

    Rybicki, Daniel J. (Inventor); Mcgee, William F. (Inventor)

    1994-01-01

    A plasma arc welding torch is described wherein a plasma gas is directed through the body of the welding torch and out of the body across the tip of the welding electrode disposed at the forward end of the body. The plasma gas is provided with a vortexing motion prior to exiting the body by a vortex motion imparting member which is mounted in an orifice housing member and carried in the forward portion of the torch body. The orifice housing member is provided with an orifice of an predetermined diameter through which the electric arc and the plasma gas exits.

  9. Efficiency, Leverage and Exit: The Role of Information Asymmetry in Concentrated Industries

    DEFF Research Database (Denmark)

    Siyahhan, Baran

    This paper develops a real options model of imperfect competition with asymmetric information that analyzes firms’ exit decisions. Optimal exit decision is linked to firm characteristics such as financial leverage and efficiency. The model shows that informational asymmetries can lead more...... efficient and less leveraged firms to leave the product market prematurely. It also demonstrates how firm efficiency can increase debt capacity relative to rival firms. The model also has implications for firm risk and asset returns. Specifically, the paper shows that, when there is information asymmetry...

  10. Predicting Success, Preventing Failure: An Investigation of the California High School Exit Exam

    Science.gov (United States)

    Zau, Andrew C.; Betts, Julian R.

    2008-01-01

    Many educators, parents, and policymakers continue to call for reforms to the California High School Exit Exam (CAHSEE), citing concern about the 10 percent of California students who do not graduate because of their failure to pass the test. By law, current funding for tutoring those at risk of failing the CAHSEE is targeted at those in grade 12…

  11. Why Do Some Employees Fall into and Fail to Exit a Job-Lock Situation?

    Directory of Open Access Journals (Sweden)

    Anna Huysse-Gaytandjieva

    2013-01-01

    Full Text Available Previous studies have paid little attention to the employees’ ability to exit a job-lock situation and factors that determine this ability. It remains unclear why some employees who experience job lock are able to exit this state while others remain in job lock. We use longitudinal data to identify employees who have fallen in the state of job lock and their subsequent behavior—exiting or remaining in job lock. By use of a first-order Markov transition models, we analyze the relevance of sociodemographic features, employment, occupational, sectoral, and contextual factors, as well as personality characteristics in explaining the transition or its absence. Overall the results show that both demographic factors and work-related aspects increase the likelihood that an employee enters the long-term job lock state (especially for older, married, full-time employed, those in a craft occupation and governmental sector, and in a region with high unemployment. Mental health problems and personality characteristics (low peak-end self-esteem and decisional procrastination have a significant effect on the probability to stay in long-term job lock. On the contrary, having a managerial, service, or associate occupation, working in the private sector, and having promotion opportunities increase the chance of an exit from the state of job lock.

  12. "Now My Old Self Is Thin": Stigma Exits after Weight Loss

    Science.gov (United States)

    Granberg, Ellen M.

    2011-01-01

    In this article, I employ a structural symbolic interaction framework to examine the processes by which persons can exit a stigmatized identity. Using the empirical example of weight loss, I analyze how individuals evolve from an identity as "fat" and stigmatized to one that is "normal" with respect to weight and free from identification with…

  13. Comparing Virtual Reference Exit Survey Results and Transcript Analysis: A Model for Service Evaluation

    Science.gov (United States)

    Smyth, Joanne B.; MacKenzie, James C.

    2006-01-01

    This study uses virtual reference transcripts for which patrons completed exit surveys to seek any correlations between user and librarian satisfaction within virtual reference transactions. By analyzing transcripts with a focus on three elements-technology performance, preferred reference practices, and the demonstrated communication levels of…

  14. 49 CFR 571.217 - Standard No. 217; Bus emergency exits and window retention and release.

    Science.gov (United States)

    2010-10-01

    ... exits and window retention and release. S1. Scope. This standard establishes requirements for the... egress. S3. Application. This standard applies to buses, except buses manufactured for the purpose of transporting persons under physical restraint. S4. Definitions. Adjacent seat means a designated...

  15. Inhibition of the mitotic exit network in response to damaged telomeres.

    Directory of Open Access Journals (Sweden)

    Mauricio Valerio-Santiago

    Full Text Available When chromosomal DNA is damaged, progression through the cell cycle is halted to provide the cells with time to repair the genetic material before it is distributed between the mother and daughter cells. In Saccharomyces cerevisiae, this cell cycle arrest occurs at the G2/M transition. However, it is also necessary to restrain exit from mitosis by maintaining Bfa1-Bub2, the inhibitor of the Mitotic Exit Network (MEN, in an active state. While the role of Bfa1 and Bub2 in the inhibition of mitotic exit when the spindle is not properly aligned and the spindle position checkpoint is activated has been extensively studied, the mechanism by which these proteins prevent MEN function after DNA damage is still unclear. Here, we propose that the inhibition of the MEN is specifically required when telomeres are damaged but it is not necessary to face all types of chromosomal DNA damage, which is in agreement with previous data in mammals suggesting the existence of a putative telomere-specific DNA damage response that inhibits mitotic exit. Furthermore, we demonstrate that the mechanism of MEN inhibition when telomeres are damaged relies on the Rad53-dependent inhibition of Bfa1 phosphorylation by the Polo-like kinase Cdc5, establishing a new key role of this kinase in regulating cell cycle progression.

  16. Ethnic variations in immigrant poverty exit and female employment: the missing link.

    Science.gov (United States)

    Kaida, Lisa

    2015-04-01

    Despite widespread interest in poverty among recent immigrants and female immigrant employment, research on the link between the two is limited. This study evaluates the effect of recently arrived immigrant women's employment on the exit from family poverty and considers the implications for ethnic differences in poverty exit. It uses the bivariate probit model and the Fairlie decomposition technique to analyze data from the Longitudinal Survey of Immigrants to Canada (LSIC), a nationally representative survey of immigrants arriving in Canada, 2000-2001. Results show that the employment of recently arrived immigrant women makes a notable contribution to lifting families out of poverty. Moreover, the wide ethnic variations in the probability of exit from poverty between European and non-European groups are partially explained by the lower employment rates among non-European women. The results suggest that the equal earner/female breadwinner model applies to low-income recent immigrant families in general, but the male breadwinner model explains the low probability of poverty exit among select non-European groups whose female employment rates are notably low. PMID:25715675

  17. The Effects of the Specialization of Private Equity Firms on their Exit Strategy

    DEFF Research Database (Denmark)

    Rigamonti, Damiana; Cefis, Elena; Meoli, Michele;

    2016-01-01

    We investigate how industry and stage specialization of Private Equity (PE) firms affect the likelihood to exit investments by means of trade sales, Initial Public Offerings (IPOs), or Secondary Buyouts (SBOs). Our empirical analysis relies on competing risks models. Using a sample of 818 Leveraged...

  18. Groningen orthopaedic exit strategy : Validation of a support program after total hip or knee arthroplasty

    NARCIS (Netherlands)

    van den Akker-Scheek, Inge; Zijlstra, Wiebren; Groothoff, Johan W.; van Horn, Jim R.; Bulstra, Sjoerd K.; Stevens, Martin

    2007-01-01

    Objective: Validation of the program theory of the Groningen orthopaedic exit strategy (GOES), a theory-driven program aiming to improve the rehabilitation of total hip and knee arthroplasty patients after shortened hospital stay. First part of the program theory is the action theory, hypothesising

  19. Compulsory Literacy and Numeracy Exit Standards for Senior Secondary Students: The Right Direction for Australia?

    Science.gov (United States)

    Rice, Suzanne; Care, Esther; Griffin, Patrick

    2012-01-01

    An overview of positive and negative potential effects of the setting of compulsory exit-level standards in literacy and numeracy for students completing their final years of schooling is presented. The overview rests on studies completed primarily outside Australia, reflecting the reality of such practices not having been implemented widely in…

  20. Why do some employees fall into and fail to exit a job-lock situation?

    Science.gov (United States)

    Huysse-Gaytandjieva, Anna; Groot, Wim; Pavlova, Milena

    2013-01-01

    Previous studies have paid little attention to the employees' ability to exit a job-lock situation and factors that determine this ability. It remains unclear why some employees who experience job lock are able to exit this state while others remain in job lock. We use longitudinal data to identify employees who have fallen in the state of job lock and their subsequent behavior-exiting or remaining in job lock. By use of a first-order Markov transition models, we analyze the relevance of sociodemographic features, employment, occupational, sectoral, and contextual factors, as well as personality characteristics in explaining the transition or its absence. Overall the results show that both demographic factors and work-related aspects increase the likelihood that an employee enters the long-term job lock state (especially for older, married, full-time employed, those in a craft occupation and governmental sector, and in a region with high unemployment). Mental health problems and personality characteristics (low peak-end self-esteem and decisional procrastination) have a significant effect on the probability to stay in long-term job lock. On the contrary, having a managerial, service, or associate occupation, working in the private sector, and having promotion opportunities increase the chance of an exit from the state of job lock. PMID:23737809

  1. Children's Reading Profiles on Exiting the Reading Recovery Programme: Do They Predict Sustained Progress?

    Science.gov (United States)

    Holliman, Andrew J.; Hurry, Jane; Bodman, Sue

    2016-01-01

    The aim of this study was to identify reading profiles, which predict the literacy progress of Reading Recovery graduates. Reading Recovery is an intensive remediation for children after the first year of school. Children were assessed at exit from the programme and at 3-month, 6-month and 12-month follow-up points. Text Reading Level made unique…

  2. Teaching Better, Teaching Together: A Coordinated Student Exit Poll across the States

    Science.gov (United States)

    Emery, Jennifer Kelkres; Howard, Alison; Evans, Jocelyn

    2014-01-01

    Student exit polling has demonstrated value in the classroom (Berry and Robinson 2012; Evans and Lagergren 2007; Lelieveldt and Rossen 2009), but faculty typically operate these polls in isolation. When faculty collaborate, however, students gain additional benefits from the experience. Collaboration provides a geographically diverse "student…

  3. Exit and Failure of Credit Unions in Brazil: A Risk Analysis

    Directory of Open Access Journals (Sweden)

    Flávio Leonel de Carvalho

    2015-04-01

    Full Text Available This study aims to investigate the factors that affect the market exit of Brazilian singular credit unions from 1995 to 2009; it also identifies and lists the determinants of various types of market exits and analyzes whether profitability is a significant factor for credit union survival. This study was conducted with accounting data provided by the Central Bank of Brazil, which derives only from individual cooperatives, i.e. singular credit unions. Quarterly financial statements from these credit unions that were active from 1995 to the second quarter of 2009 were employed, totaling 71,325 observations for 1,929 credit unions. Based on survival and the model of competing risks (such as the Cox, Exponential, Weibull, Gompertz, and Competing Risk models, the results show that there is no statistical evidence to ensure a correlation between profitability and credit union survival. The results also suggest that the size of credit unions plays a key role in their survival and longevity and that their funding and investment management are related to their survival and risk of market exit. In conclusion, the results confirm the initial idea that the duality inherent to credit unions - cooperative principles versus economic efficiency - might influence the stability, survival, and longevity of these institutions. Such results may also imply that a credit union embracing the rationale of a private bank will become more estranged from its members, something which will hinder its future operations and increase the likelihood of its exit from the market.

  4. Rational Entrepreneurship in Local China: Exit Plus Voice for Preferential Tax Treatments

    NARCIS (Netherlands)

    Z. Zhu (Ze); G.W.J. Hendrikse (George); B. Krug (Barbara)

    2006-01-01

    textabstractBearing the legacy from central-planned system, the tax system in local China still lacks transparency and, in many cases, the liabilities of firms, especially those with extensive influences, are subject to negotiation despite the new tax-reform 1994. Applying Hirschman’s Exit-Voice the

  5. Exit and Voice: Turnover and Militancy Intentions in Elementary and Secondary Schools.

    Science.gov (United States)

    Bacharach, Samuel B.; Bamberger, Peter

    1990-01-01

    Using Hirschman's conception of exit (turnover) and voice (militancy) as employee responses to objectionable working conditions, this article examines the degree to which teacher job satisfaction and stress symptomology and two hypothesized antecedents (role conflict and ambiguity) are likely to have the same effect on voicing and exiting…

  6. On a mean field game optimal control approach modeling fast exit scenarios in human crowds

    KAUST Repository

    Burger, Martin

    2013-12-01

    The understanding of fast exit and evacuation situations in crowd motion research has received a lot of scientific interest in the last decades. Security issues in larger facilities, like shopping malls, sports centers, or festivals necessitate a better understanding of the major driving forces in crowd dynamics. In this paper we present an optimal control approach modeling fast exit scenarios in pedestrian crowds. The model is formulated in the framework of mean field games and based on a parabolic optimal control problem. We consider the case of a large human crowd trying to exit a room as fast as possible. The motion of every pedestrian is determined by minimizing a cost functional, which depends on his/her position and velocity, the overall density of people, and the time to exit. This microscopic setup leads in a mean-field formulation to a nonlinear macroscopic optimal control problem, which raises challenging questions for the analysis and numerical simulations.We discuss different aspects of the mathematical modeling and illustrate them with various computational results. ©2013 IEEE.

  7. New approach of a traditional analysis for predicting near-exit jet liquid instabilities

    Science.gov (United States)

    Jaramillo, Guillermo; Collicott, Steven

    2015-11-01

    Traditional linear instability theory for round liquid jets requires an exit-plane velocity profile be assumed so as to derive the characteristic growth rates and wavelengths of instabilities. This requires solving an eigenvalue problem for the Rayleigh Equation. In this new approach, a hyperbolic tangent velocity profile is assumed at the exit-plane of a round jet and a comparison is made with a hyperbolic secant profile. Temporal and Spatial Stability Analysis (TSA and SSA respectively) are the employed analytical tools to compare results of predicted most-unstable wavelengths from the given analytical velocity profiles and from previous experimental work. The local relevance of the velocity profile in the near-exit region of a liquid jet and the validity of an inviscid formulation through the Rayleigh equation are discussed as well. A comparison of numerical accuracy is made between two different mathematical approaches for the hyperbolic tangent profile with and without the Ricatti transformation. Reynolds number based on the momentum thickness of the boundary layer at the exit plane non-dimensionalizes the problem and, the Re range, based on measurements by Portillo in 2011, is 185 to 600. Wavelength measurements are taken from Portillo's experiment. School of Mechanical Engineering at Universidad del Valle, supported by a grant from Fulbright and Colciencias. Ph.D. student at the School of Aeronautics and Astronautics Purdue University.

  8. Voice, exit and efficacy: dealing with perceived neighbourhood decline without moving out

    NARCIS (Netherlands)

    Van der Land, M.; Doff, W.

    2010-01-01

    Residents of deprived urban neighbourhoods with a changing population often experience an increase in insecurity. If they judge the change as decline, they are likely to become less satisfied with their residential situation and exhibit coping tactics. This paper combines Hirschman’s Exit, Voice and

  9. Estimates of the first Dirichlet eigenvalue from exit time moment spectra

    DEFF Research Database (Denmark)

    Hurtado, A.; Markvorsen, Steen; Palmer, V.

    2015-01-01

    We compute the first Dirichlet eigenvalue of a geodesic ball in a rotationally symmetric model space in terms of the moment spectrum for the Brownian motion exit times from the ball. As an application of the model space theory we prove lower and upper bounds for the first Dirichlet eigenvalues of...

  10. Calculation of midplane dose for total body irradiation from entrance and exit dose MOSFET measurements.

    Science.gov (United States)

    Satory, P R

    2012-03-01

    This work is the development of a MOSFET based surface in vivo dosimetry system for total body irradiation patients treated with bilateral extended SSD beams using PMMA missing tissue compensators adjacent to the patient. An empirical formula to calculate midplane dose from MOSFET measured entrance and exit doses has been derived. The dependency of surface dose on the air-gap between the spoiler and the surface was investigated by suspending a spoiler above a water phantom, and taking percentage depth dose measurements (PDD). Exit and entrances doses were measured with MOSFETs in conjunction with midplane doses measured with an ion chamber. The entrance and exit doses were combined using an exponential attenuation formula to give an estimate of midplane dose and were compared to the midplane ion chamber measurement for a range of phantom thicknesses. Having a maximum PDD at the surface simplifies the prediction of midplane dose, which is achieved by ensuring that the air gap between the compensator and the surface is less than 10 cm. The comparison of estimated midplane dose and measured midplane dose showed no dependence on phantom thickness and an average correction factor of 0.88 was found. If the missing tissue compensators are kept within 10 cm of the patient then MOSFET measurements of entrance and exit dose can predict the midplane dose for the patient. PMID:22298238

  11. On the exit from a finite interval for the risk processes with stochastic premiums

    CERN Document Server

    Gusak, D V

    2009-01-01

    In this article the almost semi-continuous step-process $\\xi (t)$ is considered. The conditional characteristic functions of the jumps of $\\xi (t)$ have the form $\\mathrm{E} [ e^{i\\alpha \\xi_k}/\\xi_k>0 ]=c(c-i\\alpha)^{-1}$. For such processes the boundary functionals connected with the exit from the finite interval are investigated.

  12. Security-Control Systems and Automation in Contemporary Buildings

    Directory of Open Access Journals (Sweden)

    Saadet Aytıs

    1999-05-01

    Full Text Available As a result of the developing technology, major renovations related to the security control systems and to building automation applications on contemporary buildings have appeared. The main item of the control systems is the entry system with cards and passwords and this is applied almost in all the large contemporary buildings. The entry and exit to/from the carparking is getting to be as important as the entry and exit to/from the building. Thus, specific measures to stop the security system being already perforated in the parking are needed. Warning systems with a great range of different detectors against various dangers that run connected to the mainframe computers and that turn on the system in case of danger are taken into consideration. The fact of obtaining all comfort conditions desired in the contemporary high space buildings and functioning of the first-aid systems are fully realized by computers with the help of systems that are called “Building Automation System” (BAS. All inspection, energy saving and security controls are achieved through these systems. In the buildings where building automation systems are applied, trained personel is needed to keep the system running; and the training of the residents about the system gains more and more importance.

  13. Laboratory Building.

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Joshua M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    This report is an analysis of the means of egress and life safety requirements for the laboratory building. The building is located at Sandia National Laboratories (SNL) in Albuquerque, NM. The report includes a prescriptive-based analysis as well as a performance-based analysis. Following the analysis are appendices which contain maps of the laboratory building used throughout the analysis. The top of all the maps is assumed to be north.

  14. A fuzzy-theory-based behavioral model for studying pedestrian evacuation from a single-exit room

    Science.gov (United States)

    Fu, Libi; Song, Weiguo; Lo, Siuming

    2016-08-01

    Many mass events in recent years have highlighted the importance of research on pedestrian evacuation dynamics. A number of models have been developed to analyze crowd behavior under evacuation situations. However, few focus on pedestrians' decision-making with respect to uncertainty, vagueness and imprecision. In this paper, a discrete evacuation model defined on the cellular space is proposed according to the fuzzy theory which is able to describe imprecise and subjective information. Pedestrians' percept information and various characteristics are regarded as fuzzy input. Then fuzzy inference systems with rule bases, which resemble human reasoning, are established to obtain fuzzy output that decides pedestrians' movement direction. This model is tested in two scenarios, namely in a single-exit room with and without obstacles. Simulation results reproduce some classic dynamics phenomena discovered in real building evacuation situations, and are consistent with those in other models and experiments. It is hoped that this study will enrich movement rules and approaches in traditional cellular automaton models for evacuation dynamics.

  15. Numerical identification of blade exit angle effect on the performance for a multistage centrifugal pump impeller

    Directory of Open Access Journals (Sweden)

    Babayigit Osman

    2015-01-01

    Full Text Available Nowadays, single and multistage centrifugal pumps are widely used in industrial and mining enterprises. One of the most important components of a centrifugal pump is the impeller. The performance characteristics are related to the pump comprising the head and the overall efficiency rely a great deal on the impeller geometry. In this work, effects of blade exit angle change on hydraulic efficiency of a multi stage pump impeller are investigated via Ansys-Fluent computational fluid dynamics software for constant width impeller entrance and exit gates, blade numbers and blade thickness. Firstly, the flow volume of a centrifugal pump impeller is generated and then mesh structure is formed for the full impeller flow volume. Secondly, rotational periodic flow model are adopted in order to examine the effect of periodic flow assumption on the performance predictions. Corresponding to the available experimental data, inlet mass flow rate, outlet static pressure and rotation of impeller are taken as 0.02m3s-1, 450 kPa and 2950 rpm, respectively for the water fluid. No slip boundary condition is exposed to all solid of surface in the flow volume. The continuity and Navier-Stokes equations with the k-ε turbulence model and the standard wall functions are used. During the study, numerical analyses are conducted for the blade exit angle values of 18°, 20°, 25°, 30° and 35°. In consequence of the performed analyses, it is determined that hydraulic efficiency of the pump impeller value is changed between 81.0-84.6%. The most convenient blade exit angle that yields 84.6% hydraulic efficiency at is 18°. The obtained results show that the blade exit angle range has an impact on the centrifugal pump performance describing the pump head and the hydraulic efficiency.

  16. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER

    Directory of Open Access Journals (Sweden)

    Yoichi Noda

    2014-07-01

    Full Text Available The Svp26 protein of S. cerevisiae is an ER- and Golgi-localized integral membrane protein with 4 potential membrane-spanning domains. It functions as an adaptor protein that facilitates the ER exit of Ktr3, a mannosyltransferase required for biosynthesis of O-linked oligosaccharides, and the ER exit of Mnn2 and Mnn5, mannosyltransferases, which participate in the biosynthesis of N-linked oligosaccharides. Ktr3 belongs to the Kre2 family, which consists of 9 members of type-II membrane proteins sharing sequence similarities. In this report, we examined all Kre2 family members and found that the Golgi localizations of two others, Kre2 and Ktr1, were dependent on Svp26 by immunofluorescence microscopy and cell fractionations in sucrose density gradients. We show that Svp26 functions in facilitating the ER exit of Kre2 and Ktr1 by an in vitro COPII budding assay. Golgi localization of Ktr4 was not dependent on Svp26. Screening null mutants of the genes encoding abundant COPII membrane proteins for those showing mislocalization of Ktr4 in the ER revealed that Erv41 and Erv46 are required for the correct Golgi localization of Ktr4. We provide biochemical evidence that the Erv41-Erv46 complex functions as an adaptor protein for ER exit of Ktr4. This is the first demonstration of the molecular function of this evolutionally conserved protein complex. The domain switching experiments show that the lumenal domain of Ktr4 is responsible for recognition by the Erv41-Erv46 complex. Thus, ER exit of Kre2-family proteins is dependent on distinct adaptor proteins and our results provide new insights into the traffic of Kre2-family mannosyltransferases.

  17. Effect of Entry/Exit Length on Flow Distribution in the Test Bundle

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Byeong Il; Jang, Beom Jun; Kim, Hong Ju; Kim, Kanghoon; Nahm, Kee Yil; Park, Sang Weon [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of)

    2014-05-15

    In data analysis, the geometric information within the heated section of the rod bundle is important because the CHF occurs in the heated section. To ensure a constant geometry and to prevent adverse flow effects, it is required to extend the same geometry beyond the heated section of rod bundle geometry. Regarding to evaluate the validity of inlet boundary condition of subchannel analysis code, the effect of the entry and exit length on the flow distribution is evaluated under the various inlet flow conditions which could be produced without flow distributor or strainer. To evaluate the validation of the inlet and outlet boundary conditions used in the subchannel analysis code, a study on the effect of the entry and exit length on the flow distribution is conducted. Even though the non-uniform flow is entered inside the test bundle, the flow gets more saturated by the simple supports and frictions. Through the code calculation under various flow conditions, it is concluded that the flow is to be fully developed flow over about 40∼80 inches of the entry length. If the exit length is about 30∼40 inches, the effect of the exit pressure can be negligible. The entry and exit length in this paper is calculated based on only rod bundles and simple supports. By installing the flow distributors or strainer, these lengths can get shorter and the flow difference between the subchannels become smaller. This study could be very useful in order to confirm the validation of the boundary conditions used in the subchannel analysis code.

  18. Numerical identification of blade exit angle effect on the performance for a multistage centrifugal pump impeller

    Science.gov (United States)

    Babayigit, Osman; Kocaaslan, Osman; Hilmi Aksoy, Muharrem; Melih Guleren, Kursad; Ozgoren, Muammer

    2015-05-01

    Nowadays, single and multistage centrifugal pumps are widely used in industrial and mining enterprises. One of the most important components of a centrifugal pump is the impeller. The performance characteristics are related to the pump comprising the head and the overall efficiency rely a great deal on the impeller geometry. In this work, effects of blade exit angle change on hydraulic efficiency of a multi stage pump impeller are investigated via Ansys-Fluent computational fluid dynamics software for constant width impeller entrance and exit gates, blade numbers and blade thickness. Firstly, the flow volume of a centrifugal pump impeller is generated and then mesh structure is formed for the full impeller flow volume. Secondly, rotational periodic flow model are adopted in order to examine the effect of periodic flow assumption on the performance predictions. Corresponding to the available experimental data, inlet mass flow rate, outlet static pressure and rotation of impeller are taken as 0.02m3s-1, 450 kPa and 2950 rpm, respectively for the water fluid. No slip boundary condition is exposed to all solid of surface in the flow volume. The continuity and Navier-Stokes equations with the k-ɛ turbulence model and the standard wall functions are used. During the study, numerical analyses are conducted for the blade exit angle values of 18°, 20°, 25°, 30° and 35°. In consequence of the performed analyses, it is determined that hydraulic efficiency of the pump impeller value is changed between 81.0-84.6%. The most convenient blade exit angle that yields 84.6% hydraulic efficiency at is 18°. The obtained results show that the blade exit angle range has an impact on the centrifugal pump performance describing the pump head and the hydraulic efficiency.

  19. 10 CFR 431.204 - Uniform test method for the measurement of energy consumption of illuminated exit signs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Uniform test method for the measurement of energy consumption of illuminated exit signs. 431.204 Section 431.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION... Procedures § 431.204 Uniform test method for the measurement of energy consumption of illuminated exit...

  20. D Topological Indoor Building Modeling Integrated with Open Street Map

    Science.gov (United States)

    Jamali, A.; Rahman, A. Abdul; Boguslawski, P.

    2016-09-01

    Considering various fields of applications for building surveying and various demands, geometry representation of a building is the most crucial aspect of a building survey. The interiors of the buildings need to be described along with the relative locations of the rooms, corridors, doors and exits in many kinds of emergency response, such as fire, bombs, smoke, and pollution. Topological representation is a challenging task within the Geography Information Science (GIS) environment, as the data structures required to express these relationships are particularly difficult to develop. Even within the Computer Aided Design (CAD) community, the structures for expressing the relationships between adjacent building parts are complex and often incomplete. In this paper, an integration of 3D topological indoor building modeling in Dual Half Edge (DHE) data structure and outdoor navigation network from Open Street Map (OSM) is presented.

  1. Rhineland Exit?

    OpenAIRE

    Bovenberg, Lans; Teulings, Coen

    2008-01-01

    We argue in favour of the shareholder model of the firm for three main reasons. First, serving multiple stakeholders leads to ill-defined property rights. What sounds like a fair compromise between stakeholders can easily evolve in a permanent struggle between the stakeholders about the ultimate goal of the company. In many cases, the vague Rhineland principles no longer offer much protection to workers. Second, giving workers a claim on the surplus of the firm raises the cost of capital for ...

  2. No Exit

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ In the weeks following the collapse of Lehman Brothers last September the number of euro banknotes in circulation suddenly increased. Fears about the rickety state of banks had made many people mistrustful of keeping money on deposit.Far safer to keep cash stuffed under a mattress. The more discriminating hoarders, it was said, were careful to squirrel away banknotes with serial numbers prefixed by the letter "X", indicating currency issued in Germany. Notes with "U"(French) or "P" (Dutch) prefix were also fine, but those with a "Y" or an "S", issued by Greece and Italy, were shunned.

  3. Exit Interviews

    OpenAIRE

    Kalyanaraman, N; M.Senthil Mathi

    2012-01-01

    As managers and leaders our success is a direct reflection of the success of our people. We are responsible top hire, coach and performance manage people who will succeed in their roles who will grow with the company as they develop their career, and who ultimately will progress beyond us in a succession plan. At the end of the day, our success is their success.

  4. Rhineland exit?

    OpenAIRE

    Bovenberg, A. Lans; Coen N. Teulings

    2008-01-01

    We argue in favour of the shareholder model of the firm for three main reasons, First, serving multiple stakeholders leads to ill-defined property rights. What sounds like a fair compromise between stakeholders can easily evolve in a permanent struggle between the stakeholders about the ultimate goal of the company. In many cases, the vague Rhineland principles no longer offer much protection to workers. Second, giving workers a claim on the surplus of the firm raises the cost of capital for ...

  5. Rhineland exit?

    OpenAIRE

    Bovenberg, Lans; Coen N. Teulings

    2007-01-01

    We argue in favour of the shareholder model of the firm for three main reasons. First, serving multiple stakeholders leads to ill-defined property rights. What sounds like a fair compromise between stakeholders can easily evolve in a permanent struggle between the stakeholders about the ultimate goal of the company. In many cases, the vague Rhineland principles no longer offer much protection to workers. Second, giving workers a claim on the surplus of the firm raises the cost of capital for ...

  6. Rhineland exit?

    OpenAIRE

    Bovenberg, Ary Lans; Coen N. Teulings

    2008-01-01

    We argue in favour of the shareholder model of the firm for three main reasons. First, serving multiple stakeholders leads to ill-defined property rights. What sounds like a fair compromise between stakeholders can easily evolve in a permanent struggle between the stakeholders about the ultimate goal of the company. In many cases, the vague Rhineland principles no longer offer much protection to workers. Second, giving workers a claim on the surplus of the firm raises the cost of capital for ...

  7. Effect of Electron Beam Orientation on Exit Wave Function via Simulation of Electron Dynamic Diffraction

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on the electron dynamic diffraction, phase shift of the exit wave function vs misorientation of the incident electron beam from the exact zone axis has been calculated for the [001] oriented copper. The result shows that the peak of phase shift is the maximum at the atom position as the electron beam along the exact [001] zone axis, and the peak value of phase shift decreases as increases of the misorientation. At small misorientation, i.e. less than 5 degree, change of the phase shift is minimal. The peak value of phase shift decreases significantly when the incident beam deviates form the zone axis over 10 degree and the exit wave has a planar configuration as the misoriention angle arrives ~17 degree. The effect of this phase shift characteristics on the information extracted from the hologram has also been considered.

  8. Relationship of core exit-temperature noise to thermal-hydraulic conditions in PWRs

    International Nuclear Information System (INIS)

    Core exit thermocouple temperature noise and neutron detector noise measurements were performed at the Loss of Fluid Test Facility (LOFT) reactor and a Westinghouse, 1148 MW(e) PWR to relate temperature noise to core thermal-hydraulic conditions. The noise analysis results show that the RMS of the temperature noise increases linearly with increasing core δT at LOFT and the commercial PWR. Out-of-core test loop temperature noise has shown similar behavior. The phase angle between core exit temperature noise and in-core or ex-core neutron noise is directly related to the core coolant flow velocity. However, if the thermocouple response time is slow, compared to the coolant transit time between the sensors, velocities inferred from the phase angle are lower than measured coolant flow velocities

  9. Microsimulations of Arching, Clogging, and Bursty Exit Phenomena in Crowd Dynamics

    CERN Document Server

    Castro, Francisco Enrique Vicente G

    2015-01-01

    We present in this paper the behavior of an artificial agent who is a member of a crowd. The behavior is based on the social comparison theory, as well as the trajectory mapping towards an agent's goal considering the agent's field of vision. The crowd of artificial agents were able to exhibit arching, clogging, and bursty exit rates. We were also able to observe a new phenomenon we called double arching, which happens towards the end of the simulation, and whose onset is exhibited by a "calm" density graph within the exit passage. The density graph is usually bursty at this area. Because of these exhibited phenomena, we can use these agents with high confidence to perform microsimulation studies for modeling the behavior of humans and objects in very realistic ways.

  10. Entrance and exit region friction factor models for annular seal analysis. Ph.D. Thesis

    Science.gov (United States)

    Elrod, David Alan

    1988-01-01

    The Mach number definition and boundary conditions in Nelson's nominally-centered, annular gas seal analysis are revised. A method is described for determining the wall shear stress characteristics of an annular gas seal experimentally. Two friction factor models are developed for annular seal analysis; one model is based on flat-plate flow theory; the other uses empirical entrance and exit region friction factors. The friction factor predictions of the models are compared to experimental results. Each friction model is used in an annular gas seal analysis. The seal characteristics predicted by the two seal analyses are compared to experimental results and to the predictions of Nelson's analysis. The comparisons are for smooth-rotor seals with smooth and honeycomb stators. The comparisons show that the analysis which uses empirical entrance and exit region shear stress models predicts the static and stability characteristics of annular gas seals better than the other analyses. The analyses predict direct stiffness poorly.

  11. Radiation degradation of aromatic pollutants exit in wastewater and ph dependence

    CERN Document Server

    Takriti, S

    2002-01-01

    The effect of gamma radiation on the degradation of phenol (hydroxybenzene), resorcinol (1,3 dihydroxybenzen) and hydroquinone (1,4 dihydroxybenzen) exit in waste water was investigated. The concentrations of these pollutants as well as the irradiated solution ph were studied. The results showed that the phenol is very resistance against the radiation doses comparing the other phenol compounds. Phenol was also a product of radiolysis of resorcinol and hydroquinone. On the other hand, the acid phase of the irradiation sample increased the degradation rate of pollutants. Spectrophotometer (UV-VIS) and chromatography (HPLC) were used to monitor the analysis of the radiation product solution. The results illustrated the existing of many substances such as organic alcohol, aldehyde, ketone and acidic functional groups as a final radiation products. The degradation of benzene, monochlorobenzene (CB) and 1,2 dichlorobenzene (1,2 DCB) exit in waste water by gamma irradiation was investigated. The effect of the irradi...

  12. Beta decay of 252Cf on the way to scission from the exit point

    CERN Document Server

    Pomorski, K; Quentin, P

    2015-01-01

    Upon increasing significantly the nuclear elongation, the beta-decay energy grows. This paper investigates within a simple yet partly microscopic approach, the transition rate of the beta decay of the 252Cf nucleus on the way to scission from the exit point for a spontaneous fission process. A rather crude classical approximation is made for the corresponding damped collective motion assumed to be one dimensional. Given these assumptions, we only aim in this paper at providing the order of magnitudes of such a phenomenon. At each deformation the energy available for beta decay, is determined from such a dynamical treatment. Then, for a given elongation, transition rates for the allowed (Fermi) beta decay are calculated from pair correlated wave functions obtained within a macroscopic-microscopic approach and then integrated over the time corresponding to the whole descent from exit to scission. The results are presented as a function of the damping factor (inverse of the characteristic damping time) in use in...

  13. Saturation margin and core exit temperature monitoring system of Loviisa nuclear power plant

    International Nuclear Information System (INIS)

    One of the lessons learned from TMI accident is that the operators need better information in the control room on cooling conditions of the reactor core. For this reason it was decided that a new system for saturation margin and core exit temperature monitoring is implemented in Loviisa nuclear power plant. The system measures primary circuit pressure, hot leg temperature and core exit temperature. The measurement signals are led to a microprocessor based digital unit for calculations and signal conditioning. As outputs of the digital unit temperatures and saturation margin are displayed in various display modes in the control room console. The paper discusses the background of the chosen system concept and the tasks of the system. A system description is presented including the equipment techniques used. A discussion of accuracy questions and testing and commissioning is presented. (author)

  14. Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.

    Science.gov (United States)

    Kafsack, Björn F C; Pena, Janethe D O; Coppens, Isabelle; Ravindran, Sandeep; Boothroyd, John C; Carruthers, Vern B

    2009-01-23

    Perforin-like proteins are expressed by many bacterial and protozoan pathogens, yet little is known about their function or mode of action. Here, we describe Toxoplasma perforin-like protein 1 (TgPLP1), a secreted perforin-like protein of the intracellular protozoan pathogen Toxoplasma gondii that displays structural features necessary for pore formation. After intracellular growth, TgPLP1-deficient parasites failed to exit normally, resulting in entrapment within host cells. We show that this defect is due to an inability to rapidly permeabilize the parasitophorous vacuole membrane and host plasma membrane during exit. TgPLP1 ablation had little effect on growth in culture but resulted in a reduction greater than five orders of magnitude of acute virulence in mice. Perforin-like proteins from other intracellular pathogens may play a similar role in microbial egress and virulence. PMID:19095897

  15. Water Entry and Exit of Horizontal Cylinder in Free Surface Flow

    International Nuclear Information System (INIS)

    This paper describes two-dimensional numerical simulations of the water entry and exit of horizontal circular cylinder at constant velocity. The deformation of free surface is described by Navier-Stokes (N S) equations of incompressible and viscous fluid with additional transport equation of the volume-of-fluid (VOF). The motion of the cylinder is modeled by the associated momentum source term implemented in the Phoenicis (Parabolic Hyperbolic Or Elliptic Numerical Integration Code Series) code. The domain is discretized by a fixed Cartesian grid using a finite volume method and the cylinder is represented and cut cell method. The simulated results are compared with the numerical results of Lin (2007). This comparison shows good agreement in terms of free surface evolution for water exit and sinking. However, for water entry, the jet flow simulated by Lin is not reproduced. The free surface deformation around the cylinder in downward direction is accurately predicted

  16. Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.

    Science.gov (United States)

    Hégarat, Nadia; Rata, Scott; Hochegger, Helfrid

    2016-07-01

    Mitotic entry and exit are switch-like transitions that are driven by the activation and inactivation of Cdk1 and mitotic cyclins. This simple on/off reaction turns out to be a complex interplay of various reversible reactions, feedback loops, and thresholds that involve both the direct regulators of Cdk1 and its counteracting phosphatases. In this review, we summarize the interplay of the major components of the system and discuss how they work together to generate robustness, bistability, and irreversibility. We propose that it may be beneficial to regard the entry and exit reactions as two separate reversible switches that are distinguished by differences in the state of phosphatase activity, mitotic proteolysis, and a dramatic rearrangement of cellular components after nuclear envelope breakdown, and discuss how the major Cdk1 activity thresholds could be determined for these transitions. PMID:27231150

  17. Use of coal and coal exit in Germany from the perspective of the population

    International Nuclear Information System (INIS)

    The objective of the energy policy to reduce greenhouse gas emissions by 2050 up to 80 to 95% compared to 1990, can be achieved only by a substantial decarbonisation of the energy production. For this purpose, in addition to the assessment of the technical and economic effects, information is necessary which views the population has use to coal and coal exit in Germany. Based on the results of a representative panel survey is first identified what citizens know about the use of coal, which attitudes they have and how they value the need for coal power plants. Then the awareness of the topic of coal exit in Germany, the understanding of the respondents, and the attitudes of the population to it will be illustrated.

  18. Observation of strong reflection of electron waves exiting a ballistic channel at low energy

    Science.gov (United States)

    Vaz, Canute I.; Liu, Changze; Campbell, Jason P.; Ryan, Jason T.; Southwick, Richard G., III; Gundlach, David; Oates, Anthony S.; Huang, Ru; Cheung, Kin. P.

    2016-06-01

    Wave scattering by a potential step is a ubiquitous concept. Thus, it is surprising that theoretical treatments of ballistic transport in nanoscale devices, from quantum point contacts to ballistic transistors, assume no reflection even when the potential step is encountered upon exiting the device. Experiments so far seem to support this even if it is not clear why. Here we report clear evidence of coherent reflection when electron wave exits the channel of a nanoscale transistor and when the electron energy is low. The observed behavior is well described by a simple rectangular potential barrier model which the Schrodinger's equation can be solved exactly. We can explain why reflection is not observed in most situations but cannot be ignored in some important situations. Our experiment also represents a direct measurement of electron injection velocity - a critical quantity in nanoscale transistors that is widely considered not measurable.

  19. Design, durability and low cost processing technology for composite fan exit guide vanes

    Science.gov (United States)

    Blecherman, S. S.

    1980-01-01

    A program was conducted to design, fabricate and test a durable, low cost, lightweight composite fan exit guide vane for high bypass ratio gas turbine engine application. Eight candidate material/design combinations were evaluated by NASTRAN finite element analysis. Four of these candidate systems were selected for composite vane fabrication by two vendors. A core and shell vane design was chosen in which the unidirectional graphite core fiber was the same for all candidates. The shell material, fiber orientation and ply configuration were varied. Material tests were performed on raw material and composite specimens to establish specification requirements. Composite vanes were nondestructively inspected and subsequently fatigue tested in both dry and 'wet' conditions. The program provided relevant data with respect to design analysis, materials properties, inspection standards, improved durability, weight benefits and part price of the composite fan exit guide vane.

  20. Exit and voice: a game-theoretic analysis of customer complaint management

    OpenAIRE

    Liang, Pinghan

    2013-01-01

    We develop a multi-agent communication model with participation decisions to address the customer complaining behavior and the corresponding management policy. Privately informed customers choose among costly complain, keep silence, and exit, and a firm decides complaining barriers and whether to undertake a corrective action. It is shown that customers truthfully complain only under a moderate complaining barrier. The observed low complaint/dissatisfaction ratio and costly complaint arise as...

  1. Could one single dichotomous noise cause resonant activation for exit time over potential barrier?

    Institute of Scientific and Technical Information of China (English)

    Li Jing-Hui

    2008-01-01

    This paper studies the mean first passage time (or exit time, or escape time) over the non-fluctuating potential barrier for a system driven only by a dichotomous noise. It finds that the dichotomous noise can make the particles escape over the potential barrier, in some circumstances; but in other circumstances, it can not. In the case that the particles escape over the potential barrier, a resonant activation phenomenon for the mean first passage time over the potential barrier is obtained.

  2. To what is a transition into employment associated with an exit from poverty?

    OpenAIRE

    Galloway, Taryn Ann

    2004-01-01

    A link between lack of employment and poverty is often made implicitly, but can rarely be enumerated in any sort of satisfactory manner. We would therefore like to ask the question: to what extent does acquiring employment increase a poor household’s probability of exiting poverty? Register data from the entire resident population of Norway serves as the basis for the analysis. We distinguish between full-time and part-time employment and also include an investigation into the effect transfer...

  3. To what extent is a transition into employment associated with an exit from poverty

    OpenAIRE

    2004-01-01

    A link between lack of employment and poverty is often made implicitly, but can rarely be enumerated in any sort of satisfactory manner. We would therefore like to ask the question: to what extent does acquiring employment increase a poor household’s probability of exiting poverty? Register data from the entire resident population of Norway serves as the basis for the analysis. We distinguish between full-time and part-time employment and also include an investigation into the effect transfer...

  4. An experimental study of exit flow patterns in a multistage compressor in rotating stall

    OpenAIRE

    Gorrell, Steven Ernest

    1990-01-01

    High-response pressure measurements of a high-speed, 10- stage, axial-flow compressor operating in rotating stall are analyzed. Procedures used to digitize analog voltages and calibrate pressure transducers are presented. From total and static pressures measured at the exit of the test compressor, stall cell Mach number distributions are calculated and used to study the effects of discharge throttle levels and variable vane changes on the 10th-stage rotating stall cells. ...

  5. Pid Plus Fuzzy Logic Controller Based Electronic Load Controller For Self Exited Induction Generator.

    OpenAIRE

    S.Swathi,; V. Vijaya Kumar Nayak

    2014-01-01

    This paper deals with the electronic load controller for self exited induction generator using PID plus fuzzy logic controller. The self-excited induction generators (SEIGs) are considered to be well suited for generating electricity by means of conventional energy sources and for supplying electrical energy in remote and rural areas. Induction generators have many advantages such as cost, reduced maintenance, rugged, and simple construction, brushless rotor (squirrel cage). A...

  6. Peritonitis and catheter exit-site infection in patients on peritoneal dialysis at home

    OpenAIRE

    Ana Cristina Freire Abud; Luciana Kusumota; Manoel Antônio dos Santos; Flávia Fernanda Luchetti Rodrigues; Marta Maria Coelho Damasceno; Maria Lúcia Zanetti

    2015-01-01

    Objective: to analyze the complications related to peritonitis and catheter exit-site infections, in patients on peritoneal dialysis at home. Method: quantitative and cross-sectional study, carried out with 90 patients on peritoneal dialysis at home, in a municipality in the Northeast region of Brazil. For data collection, it was used two structured scripts and consultation on medical records. Descriptive analysis and comparison tests among independent groups were used, considering p

  7. Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure

    OpenAIRE

    Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne

    2012-01-01

    The ex-utero intrapartum treatment (EXIT) is one type of fetal surgery, performed before delivery while the fetus remains attached to the uteroplacental circulation. This intervention improves neonatal morbidity and mortality of certain congenital diseases. For instance, securing the airway of a fetus with congenital airway obstruction while on uteroplacental circulation prevents the hypoxemia during the establishment of an airway post-delivery. Anesthesia for fetal surgery now incorporates n...

  8. Adapting the reactors Melusine and Siloe to the needs of basic research on exit beams

    International Nuclear Information System (INIS)

    This report shows how CENG swimming pools can be adapted to meet developing needs of basic research on exit beams. The experimental facilities offered are: two radial channels on Siloe and three radial and two tangential channels on Melusine. The use of various channels is outlined and modifications made to the channels described. Improvements involved the socks, protective shielding systems and collimator plugs and at Melusine, the installation of a heavy water tank. Some future trends are outlined

  9. Analysis of the Convergence Process by EXIT Charts for Parallel Implementations of Turbo Decoders

    OpenAIRE

    Sanchez, O.; Jego, Christophe; JEZEQUEL, Michel

    2013-01-01

    International audience Iterative process is a general principle in decoding powerful FEC codes such as turbo codes. However, the mutual information exchange during the iterative process is not easy to analyze and to describe. A useful technique to help the designer is the EXtrinsic Information Transfer (EXIT) chart. Unfortunately, this method cannot be directly applied to the decoding convergence analysis if parallel processing has to be exploited for the design of turbo decoders. In this ...

  10. Numerical identification of blade exit angle effect on the performance for a multistage centrifugal pump impeller

    OpenAIRE

    Babayigit Osman; Kocaaslan Osman; Aksoy Muharrem Hilmi; Guleren Kursad Melih; Ozgoren Muammer

    2015-01-01

    Nowadays, single and multistage centrifugal pumps are widely used in industrial and mining enterprises. One of the most important components of a centrifugal pump is the impeller. The performance characteristics are related to the pump comprising the head and the overall efficiency rely a great deal on the impeller geometry. In this work, effects of blade exit angle change on hydraulic efficiency of a multi stage pump impeller are investigated via Ansys-Fluent computational fluid dynamics sof...

  11. Working with children? the probability of mothers exiting the workforce at time of birth

    OpenAIRE

    Hotchkiss, Julie L.; Pitts, M. Melinda; Walker, Mary Beth

    2008-01-01

    Recent trends in the labor force participation of women have brought much public attention to the issue of women opting out. This paper explores the decision of working women to exit the labor market at a time of major transition - the birth of a child - utilizing linked vital statistics, administrative employer, and state welfare records. The results indicate that, consistent with utility maximization theory, women are not just opting out but rather are accurately assessing the potential opp...

  12. Determination of exit skin dose for 192Ir intracavitary accelerated partial breast irradiation with thermoluminescent dosimeters

    OpenAIRE

    Raffi, Julie A.; Stephen D. Davis; Hammer, Cliff G.; Micka, John A.; Kunugi, Keith A.; Musgrove, Jana E.; Winston, John W.; Ricci-Ott, Terresa J.; DeWerd, Larry A.

    2010-01-01

    Purpose: Intracavitary accelerated partial breast irradiation (APBI) has become a popular treatment for early stage breast cancer in recent years due to its shortened course of treatment and simplified treatment planning compared to traditional external beam breast conservation therapy. However, the exit dose to the skin is a major concern and can be a limiting factor for these treatments. Most treatment planning systems (TPSs) currently used for high dose-rate (HDR) 192Ir brachytherapy overe...

  13. Investigation on Divergent Exit Curvature Effect on Nozzle Pressure Ratio of Supersonic Convergent Divergent Nozzle

    OpenAIRE

    aShyamshankar.M.B; Sankar.V

    2015-01-01

    The objective of this project work is to computationally analyze shock waves in the Convergent Divergent (CD) Nozzle. The commercial CFD code Fluent is employed to analyze the compressible flow through the nozzle. The analysis is about NPR (Nozzle Pressure Ratio) i.e., the ratio between exit pressure of the nozzle to ambient pressure. The various models of CD Nozzle are designed and the results are compared. The flow characteristic of shockwave for various design of CD Nozzle is a...

  14. Building Inclusion

    NARCIS (Netherlands)

    Jeanet Kullberg; Isik Kulu-Glasgow

    2009-01-01

    The social inclusion of immigrants and ethnic minorities is a central issue in many European countries. Governments face challenges in ensuring housing for immigrants, delivering public services, promoting neighbourhood coexistence and addressing residential segregation. The Building Inclusion proje

  15. Building Languages

    Science.gov (United States)

    ... family's native language) is taught as the child's second language through reading, writing, speech, and use of residual ... that parents can use to help their child learn language. There are many types of building blocks, and ...

  16. Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit.

    Directory of Open Access Journals (Sweden)

    Nidhi Gera

    Full Text Available The anti-tumor effects of chemotherapy and radiation are thought to be mediated by triggering G1/S or G2/M cell cycle checkpoints, while spindle poisons, such as paclitaxel, block metaphase exit by initiating the spindle assembly checkpoint. In contrast, we have found that 150 kilohertz (kHz alternating electric fields, also known as Tumor Treating Fields (TTFields, perturbed cells at the transition from metaphase to anaphase. Cells exposed to the TTFields during mitosis showed normal progression to this point, but exhibited uncontrolled membrane blebbing that coincided with metaphase exit. The ability of such alternating electric fields to affect cellular physiology is likely to be dependent on their interactions with proteins possessing high dipole moments. The mitotic Septin complex consisting of Septin 2, 6 and 7, possesses a high calculated dipole moment of 2711 Debyes (D and plays a central role in positioning the cytokinetic cleavage furrow, and governing its contraction during ingression. We showed that during anaphase, TTFields inhibited Septin localization to the anaphase spindle midline and cytokinetic furrow, as well as its association with microtubules during cell attachment and spreading on fibronectin. After aberrant metaphase exit as a consequence of TTFields exposure, cells exhibited aberrant nuclear architecture and signs of cellular stress including an overall decrease in cellular proliferation, followed by apoptosis that was strongly influenced by the p53 mutational status. Thus, TTFields are able to diminish cell proliferation by specifically perturbing key proteins involved in cell division, leading to mitotic catastrophe and subsequent cell death.

  17. Exit of Plasmodium sporozoites from oocysts is an active process that involves the circumsporozoite protein.

    Directory of Open Access Journals (Sweden)

    2005-09-01

    Full Text Available Plasmodium sporozoites develop within oocysts residing in the mosquito midgut. Mature sporozoites exit the oocysts, enter the hemolymph, and invade the salivary glands. The circumsporozoite (CS protein is the major surface protein of salivary gland and oocyst sporozoites. It is also found on the oocyst plasma membrane and on the inner surface of the oocyst capsule. CS protein contains a conserved motif of positively charged amino acids: region II-plus, which has been implicated in the initial stages of sporozoite invasion of hepatocytes. We investigated the function of region II-plus by generating mutant parasites in which the region had been substituted with alanines. Mutant parasites produced normal numbers of sporozoites in the oocysts, but the sporozoites were unable to exit the oocysts. In in vitro as well, there was a profound delay, upon trypsin treatment, in the release of mutant sporozoites from oocysts. We conclude that the exit of sporozoites from oocysts is an active process that involves the region II-plus of CS protein. In addition, the mutant sporozoites were not infective to young rats. These findings provide a new target for developing reagents that interfere with the transmission of malaria.

  18. A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.

    Science.gov (United States)

    Cundell, Michael J; Hutter, Lukas H; Nunes Bastos, Ricardo; Poser, Elena; Holder, James; Mohammed, Shabaz; Novak, Bela; Barr, Francis A

    2016-08-29

    PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are recognized and differentially dephosphorylated is unclear. Using phosphoproteomics combined with kinetic modeling to extract B55-dependent rate constants, we have systematically identified B55 substrates and assigned their temporal order in mitotic exit. These substrates share a bipartite polybasic recognition determinant (BPR) flanking a Cdk1 phosphorylation site. Experiments and modeling show that dephosphorylation rate is encoded into B55 substrates, including its inhibitor ENSA, by cooperative action of basic residues within the BPR. A complementary acidic surface on B55 decodes this signal, supporting a cooperative electrostatic mechanism for substrate selection. A further level of specificity is encoded into B55 substrates because B55 displays selectivity for phosphothreonine. These simple biochemical properties, combined with feedback control of B55 activity by the phosphoserine-containing substrate/inhibitor ENSA, can help explain the temporal sequence of events during exit from mitosis. PMID:27551054

  19. Chk2 prevents mitotic exit when the majority of kinetochores are unattached.

    Science.gov (United States)

    Petsalaki, Eleni; Zachos, George

    2014-05-12

    The spindle checkpoint delays exit from mitosis in cells with spindle defects. In this paper, we show that Chk2 is required to delay anaphase onset when microtubules are completely depolymerized but not in the presence of relatively few unattached kinetochores. Mitotic exit in Chk2-deficient cells correlates with reduced levels of Mps1 protein and increased Cdk1-tyrosine 15 inhibitory phosphorylation. Chk2 localizes to kinetochores and is also required for Aurora B-serine 331 phosphorylation in nocodazole or unperturbed early prometaphase. Serine 331 phosphorylation contributed to prometaphase accumulation in nocodazole after partial Mps1 inhibition and was required for spindle checkpoint establishment at the beginning of mitosis. In addition, expression of a phosphomimetic S331E mutant Aurora B rescued chromosome alignment or segregation in Chk2-deficient cells. We propose that Chk2 stabilizes Mps1 and phosphorylates Aurora B-serine 331 to prevent mitotic exit when most kinetochores are unattached. These results highlight mechanisms of an essential function of Chk2 in mitosis.

  20. Modeling of Two-Phase Flow through a Rotating Tube with Twin Exit Branches

    Directory of Open Access Journals (Sweden)

    Sun-Wen Cheng

    2000-01-01

    Full Text Available A numerical model is proposed to determine the dynamic behavior of single-phase and twophase, two-component flows through a horizontal rotating tube with identical twin exit branches. The working fluid, oil, enters the tube through a radial duct attached at one end and exits into open air through the twin radial branches, one located at midway and the other at the end of the tube. The branch-to-tube diameter ratio, rotational speed, and total oil flow rate are varied. It is experimentally revealed in previous study that the air cavitation occurs at lower speeds, leading to a two-phase flow with the air-oil ratio (void fraction varying with the rotating speed. A unique characteristic in two-phase flow, i.e., hysteresis, is found to exist in both oil flow rates and inlet pressure. In theoretical modeling, the governing flow equations are incorporated by empirical equations for hydraulic head losses. The predicted and measured exit oil flow rates are compared with good agreement in both the single-phase and annular flow regimes. Only qualitative agreement is achieved in the bubbly and bubbly-slug flow regimes. The model can be applied to improve the design and thus enhance the performance of automatic transmission lines, and the cooling efficiency of rotating machines and petroleum drilling process.

  1. Pitx2 expression promotes p21 expression and cell cycle exit in neural stem cells.

    Science.gov (United States)

    Heldring, Nina; Joseph, Bertrand; Hermanson, Ola; Kioussi, Chrissa

    2012-11-01

    Cortical development is a complex process that involves many events including proliferation, cell cycle exit and differentiation that need to be appropriately synchronized. Neural stem cells (NSCs) isolated from embryonic cortex are characterized by their ability of self-renewal under continued maintenance of multipotency. Cell cycle progression and arrest during development is regulated by numerous factors, including cyclins, cyclin dependent kinases and their inhibitors. In this study, we exogenously expressed the homeodomain transcription factor Pitx2, usually expressed in postmitotic progenitors and neurons of the embryonic cortex, in NSCs with low expression of endogenous Pitx2. We found that Pitx2 expression induced a rapid decrease in proliferation associated with an accumulation of NSCs in G1 phase. A search for potential cell cycle inhibitors responsible for such cell cycle exit of NSCs revealed that Pitx2 expression caused a rapid and dramatic (≉20-fold) increase in expression of the cell cycle inhibitor p21 (WAF1/Cip1). In addition, Pitx2 bound directly to the p21 promoter as assessed by chromatin immunoprecipitation (ChIP) in NSCs. Surprisingly, Pitx2 expression was not associated with an increase in differentiation markers, but instead the expression of nestin, associated with undifferentiated NSCs, was maintained. Our results suggest that Pitx2 promotes p21 expression and induces cell cycle exit in neural progenitors.

  2. A Reconfigurable Functional Unit with Conditional Execution for Multi-Exit Custom Instructions

    Science.gov (United States)

    Noori, Hamid; Mehdipour, Farhad; Inoue, Koji; Murakami, Kazuaki

    Encapsulating critical computation subgraphs as application-specific instruction set extensions is an effective technique to enhance the performance of embedded processors. However, the addition of custom functional units to the base processor is required to support the execution of these custom instructions. Although automated tools have been developed to reduce the long design time needed to produce a new extensible processor for each application, short time-to-market, significant non-recurring engineering and design costs are issues. To address these concerns, we introduce an adaptive extensible processor in which custom instructions are generated and added after chip-fabrication. To support this feature, custom functional units (CFUs) are replaced by a reconfigurable functional unit (RFU). The proposed RFU is based on a matrix of functional units which is multi-cycle with the capability of conditional execution. A quantitative approach is utilized to propose an efficient architecture for the RFU and fix its constraints. To generate more effective custom instructions, they are extended over basic blocks and hence, multiple exits custom instructions are proposed. Conditional execution has been added to the RFU to support the multi-exit feature of custom instructions. Experimental results show that multi-exit custom instructions enhance the performance by an average of 67% compared to custom instructions limited to one basic block. A maximum speedup of 4.7, compared to a general embedded processor, and an average speedup of 1.85 was achieved on MiBench benchmark suite.

  3. Gate C – Works on the Building 42

    CERN Multimedia

    GS Department

    2009-01-01

    Due to works being carried out on the new building 42, lorries transporting concrete will be entering and exiting the site via entrance C (during entrance C opening hours and between July and December 2009). The lorries have PRIORITY over other vehicles, please adapt your speed in consequence. We thank you in advance for your patience and vigilance when using this entrance. GS-SEM Group Infrastructure and General Services Department

  4. To fish or not to fish: factors at multiple scales affecting artisanal fishers' readiness to exit a declining fishery.

    Directory of Open Access Journals (Sweden)

    Tim M Daw

    Full Text Available Globally, fisheries are challenged by the combined impacts of overfishing, degradation of ecosystems and impacts of climate change, while fisheries livelihoods are further pressured by conservation policy imperatives. Fishers' adaptive responses to these pressures, such as exiting from a fishery to pursue alternative livelihoods, determine their own vulnerability, as well as the potential for reducing fishing effort and sustaining fisheries. The willingness and ability to make particular adaptations in response to change, such as exiting from a declining fishery, is influenced by economic, cultural and institutional factors operating at scales from individual fishers to national economies. Previous studies of exit from fisheries at single or few sites, offer limited insight into the relative importance of individual and larger-scale social and economic factors. We asked 599 fishers how they would respond to hypothetical scenarios of catch declines in 28 sites in five western Indian Ocean countries. We investigated how socioeconomic variables at the individual-, household- and site-scale affected whether they would exit fisheries. Site-level factors had the greatest influence on readiness to exit, but these relationships were contrary to common predictions. Specifically, higher levels of infrastructure development and economic vitality - expected to promote exit from fisheries - were associated with less readiness to exit. This may be due to site level histories of exit from fisheries, greater specialisation of fishing households, or higher rewards from fishing in more economically developed sites due to technology, market access, catch value and government subsidies. At the individual and household scale, fishers from households with more livelihood activities, and fishers with lower catch value were more willing to exit. These results demonstrate empirically how adaptive responses to change are influenced by factors at multiple scales, and

  5. Toward Simulation-Based Egress Optimization in Smart Buildings Using Symbiotic Simulation

    NARCIS (Netherlands)

    H. Aydt; M.H. Lees; S.J. Turner; W. Cai

    2012-01-01

    Buildings have to satisfy certain safety standards by design, for example by featuring well-displayed emergency exits and well-located fire extinguishers. However, the large number of occupants may cause significant congestion in case of a necessary evacuation due to events such as fire. Technology

  6. Competence Building

    DEFF Research Database (Denmark)

    Borrás, Susana; Edquist, Charles

    The main question that guides this paper is how governments are focusing (and must focus) on competence building (education and training) when designing and implementing innovation policies. With this approach, the paper aims at filling the gap between the existing literature on competences...... on the one hand, and the real world of innovation policy-making on the other, typically not speaking to each other. With this purpose in mind, this paper discusses the role of competences and competence-building in the innovation process from a perspective of innovation systems; it examines how governments...... and public agencies in different countries and different times have actually approached the issue of building, maintaining and using competences in their innovation systems; it examines what are the critical and most important issues at stake from the point of view of innovation policy, looking particularly...

  7. Building Procurement

    DEFF Research Database (Denmark)

    Andersson, Niclas

    2007-01-01

    ‘The procurement of construction work is complex, and a successful outcome frequently elusive’. With this opening phrase of the book, the authors take on the challenging job of explaining the complexity of building procurement. Even though building procurement systems are, and will remain, complex...... despite this excellent book, the knowledge, expertise, well-articulated argument and collection of recent research efforts that are provided by the three authors will help to make project success less elusive. The book constitutes a thorough and comprehensive investigation of building procurement, which...... evolves from a simple establishment of a contractual relationship to a central and strategic part of construction. The authors relate to cultural, ethical and social and behavioural sciences as the fundamental basis for analysis and understanding of the complexity and dynamics of the procurement system...

  8. Temperature and pressure measurements at cold exit of counter-flow vortex tube with flow visualization of reversed flow

    Science.gov (United States)

    Yusof, Mohd Hazwan bin; Katanoda, Hiroshi; Morita, Hiromitsu

    2015-02-01

    In order to clarify the structure of the cold flow discharged from the counter-flow vortex tube (VT), the temperature and pressure of the cold flow were measured, and the existence and behavior of the reversed flow at the cold exit was studied using a simple flow visualization technique consisting of a 0.75mm-diameter needle, and an oil paint droplet. It is observed through this experiment that the Pitot pressure at the cold exit center can either be lower or higher than atmospheric pressure, depending on the inlet pressure and the cold fraction, and that a reversed flow is observed when the Pitot pressure at the cold exit center is lower than atmospheric pressure. In addition, it is observed that when reducing the cold fraction from unity at any arbitrary inlet pressure, the region of reversed and colder flow in the central part of cold exit extends in the downstream direction.

  9. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...... in the Media”, “Audience Interactivity and Participation”, “The Role of Media and ICT Use for Evolving Social Relationships” and “Audience Transformations and Social Integration”. Building Bridges is the result of an ongoing dialogue between the Action and non-academic stakeholders in the field of audience...

  10. To leave or not to leave?: a regression discontinuity analysis of the impact of failing high school exit exam

    OpenAIRE

    Ou, Dongshu

    2009-01-01

    The high school exit exam (HSEE) is rapidly becoming a standardized assessment procedure for educational accountability in the United States. I use a unique state-specific dataset to identify the effect of failing the HSEE on the likelihood that a student drops out early based on a Regression Discontinuity design. It shows that students who barely fail the exam are more likely to exit than those who barely pass despite being offered retest opportunities. The discontinuity amounts to a large p...

  11. As the market churns : estimates of firm exit and job loss using the World Bank's enterprise surveys

    OpenAIRE

    Aga, Gemechu; Francis, David

    2015-01-01

    This paper uses a unique data set of panel firms from the World Bank's Enterprise Surveys in 47 economies, to provide estimates of the patterns of firm exit, and analyzes various firm characteristics and conditions under which firms leave the market. Firms' labor productivity and age are robustly associated with a lower likelihood of exit, consistent with conceptions of creative destruction and findings elsewhere in the literature. These findings are robust across several specifications. Howe...

  12. UC3M Emergencies : health center search, first aid, defibrillators, emergency exits, last warnings and torch (iOS platform)

    OpenAIRE

    Martín Civiac, María

    2013-01-01

    This document contains Maria Martin’s bachelor thesis. The issues that this project wants to solve are emergencies-related: health centersand emergency exits location,emergency call, first aid instructions and information and latest emergency alerts at Carlos III University. It has been detected that members of Carlos III University currently have difficulties to find health centers, emergency exits and first aid information. Furthermore, the University itself did not have any mechanism to pu...

  13. Exit blade geometry and part-load performance of small axial flow propeller turbines: An experimental investigation

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Punit; Nestmann, Franz [Institute for Water and River Basin Management (IWG), University of Karlsruhe, Kaiser Str. 12, D 76128 Karlsruhe (Germany)

    2010-09-15

    A detailed experimental investigation of the effects of exit blade geometry on the part-load performance of low-head, axial flow propeller turbines is presented. Even as these turbines find important applications in small-scale energy generation using micro-hydro, the relationship between the layout of blade profile, geometry and turbine performance continues to be poorly characterized. The experimental results presented here help understand the relationship between exit tip angle, discharge through the turbine, shaft power, and efficiency. The modification was implemented on two different propeller runners and it was found that the power and efficiency gains from decreasing the exit tip angle could be explained by a theoretical model presented here based on classical theory of turbomachines. In particular, the focus is on the behaviour of internal parameters like the runner loss coefficient, relative flow angle at exit, mean axial flow velocity and net tangential flow velocity. The study concluded that the effects of exit tip modification were significant. The introspective discussion on the theoretical model's limitation and test facility suggests wider and continued experimentation pertaining to the internal parameters like inlet vortex profile and exit swirl profile. It also recommends thorough validation of the model and its improvement so that it can be made capable for accurate characterization of blade geometric effects. (author)

  14. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...

  15. Sustainable Buildings

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Elle, Morten

    The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems...

  16. Britain’s Exit from the EU and the Implications for Austria

    OpenAIRE

    Sigalas, Emmanuel

    2014-01-01

    In Austria a “Brexit” is still treated as a hypothetical scenario, even though the debate of a possible British exit from the EU has acquired momentum in the UK. The present IHS Standpunkt argues that Austria’s pro-Europe forces ought to coordinate their efforts with their partners in other countries, in order to prevent the unravelling of the EU. Austria has a lot to lose if Britain leaves the EU, and the losses are not only economic in nature but political as well. A potential Brexit will s...

  17. An annular gas seal analysis using empirical entrance and exit region friction factors

    Science.gov (United States)

    Elrod, D. A.; Childs, D. W.; Nelson, C. C.

    1990-01-01

    Wall shear stress results from stationary-rotor flow tests of five annular gas seals are used to develop entrance and exit region friction factor models. The friction factor models are used in a bulk-flow seal analysis which predicts leakage and rotor-dynamic coefficients. The predictions of the analysis are compared to experimental results and to the predictions of Nelson's analysis (1985). The comparisons are for smooth-rotor seals with smooth and honeycomb-stators. The present analysis predicts the destabilizing cross-coupled stiffness of a seal better than Nelson's analysis. Both analyses predict direct damping well and direct stiffness poorly.

  18. Exiting RCRA Subtitle C regulation data for supporting a new regulatory path for immobilized mixed debris

    Energy Technology Data Exchange (ETDEWEB)

    Porter, C.L. [Jetseal, Inc., Idaho Falls, ID (United States); Carson, S.D.; Cheng, Wu-Ching [Sandia National Labs., Albuquerque, NM (United States)

    1995-12-31

    This paper presents analytical and empirical data that provide technical support for the position that mixed debris (debris contaminated with both radioactive and hazardous constituents) treated by immobilization in accordance with 40 CFR 268.45 can exit RCRA Subtitle C requirements at the time the treatment is complete. Pathways analyses and risk assessments of low-level waste and RCRA mixed waste disposal facilities show that these two types of facilities provide equivalent long-term (> 100 years) performance and protection of human health and the environment. A proposed two-tier approach for waste form performance criteria is discussed.

  19. Exit and Occupation times for Brownian Motion on Graphs with General Drift and Diffusion Constant

    OpenAIRE

    Benichou, O.; Desbois, J.

    2008-01-01

    We consider a particle diffusing along the links of a general graph possessing some absorbing vertices. The particle, with a spatially-dependent diffusion constant D(x) is subjected to a drift U(x) that is defined in every point of each link. We establish the boundary conditions to be used at the vertices and we derive general expressions for the average time spent on a part of the graph before absorption and, also, for the Laplace transform of the joint law of the occupation times. Exit time...

  20. Exit and occupation times for Brownian motion on graphs with general drift and diffusion constant

    International Nuclear Information System (INIS)

    We consider a particle diffusing along the links of a general graph possessing some absorbing vertices. The particle, with a spatially dependent diffusion constant D(x), is subjected to a drift U(x) that is defined in every point of each link. We establish the boundary conditions to be used at the vertices and we derive general expressions for the average time spent on a part of the graph before absorption and, also, for the Laplace transform of the joint law of the occupation times. Exit times distributions and splitting probabilities are also studied and several examples are discussed

  1. Exit and occupation times for Brownian motion on graphs with general drift and diffusion constant

    Energy Technology Data Exchange (ETDEWEB)

    Benichou, Olivier [Laboratoire de Physique Theorique de la Matiere Condensee, Universite Pierre et Marie Curie, 4, place Jussieu, 75005 Paris (France); Desbois, Jean [Laboratoire de Physique Theorique et Modeles Statistiques. Universite Paris-Sud, Bat. 100, F-91405 Orsay Cedex (France)

    2009-01-09

    We consider a particle diffusing along the links of a general graph possessing some absorbing vertices. The particle, with a spatially dependent diffusion constant D(x), is subjected to a drift U(x) that is defined in every point of each link. We establish the boundary conditions to be used at the vertices and we derive general expressions for the average time spent on a part of the graph before absorption and, also, for the Laplace transform of the joint law of the occupation times. Exit times distributions and splitting probabilities are also studied and several examples are discussed.

  2. Microanatomy and Histological Features of Central Myelin in the Root Exit Zone of Facial Nerve

    OpenAIRE

    Yee, Gi-Taek; Yoo, Chan-Jong; Han, Seong-Rok; Choi, Chan-Young

    2014-01-01

    Objective The aim of this study was to evaluate the microanatomy and histological features of the central myelin in the root exit zone of facial nerve. Methods Forty facial nerves with brain stem were obtained from 20 formalin fixed cadavers. Among them 17 facial nerves were ruined during preparation and 23 root entry zone (REZ) of facial nerves could be examined. The length of medial REZ, from detach point of facial nerve at the brain stem to transitional area, and the thickness of glial mem...

  3. Asymmetric parental genome engineering by Cas9 during mouse meiotic exit

    OpenAIRE

    Toru Suzuki; Maki Asami; Perry, Anthony C. F.

    2014-01-01

    Mammalian genomes can be edited by injecting pronuclear embryos with Cas9 cRNA and guide RNA (gRNA) but it is unknown whether editing can also occur during the onset of embryonic development, prior to pronuclear embryogenesis. We here report Cas9-mediated editing during sperm-induced meiotic exit and the initiation of development. Injection of unfertilized, mouse metaphase II (mII) oocytes with Cas9 cRNA, gRNA and sperm enabled efficient editing of transgenic and native alleles. Pre-loading o...

  4. The Entry and Exit Dynamics of Self-employment in Canada

    OpenAIRE

    Lin, Zhengxi; Picot, Garnett; Yates, Janice

    1999-01-01

    This paper i) documents the extent and cyclicality of self-employment entry and exit flows; ii) explores transitions to and from self-employment; and iii) investigates the influence of individual characteristics and labour market experience as well as macroeconomic conditions on the probability of moving into or out of self-employment. The self-employed sector now employs over two and a half million Canadian workers, has expanded on average by over 4% a year so far in this decade and accounte...

  5. HoReCa-asiakkaiden tuotteen x asiakassuhteen exit-haastattelut

    OpenAIRE

    Rokkonen, Saara

    2011-01-01

    Uusien asiakkaiden hankkiminen tulee yrityksille kalliimmaksi kuin vanhojen asiakkaiden pi-täminen. Jo tästä syystä yritysten kannattaa pitää vanhat asiakkaat tyytyväisinä ja panostaa heille tarjoamiinsa tuotteisiin ja palveluihin kokonaisvaltaisesti. Useissa yrityksissä tutkitaan vuosittain asiakastyytyväisyyttä erilaisilla menetelmillä ja mittareilla. Harvoin kukaan kuitenkaan kiinnittää huomiota jo menetettyihin asiakkaisiin ja lähdön syihin. Exit-haastatteluista saatavan tiedon avulla voi...

  6. Inflation in string theory. A graceful exit to the real world

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Mazumdar, Anupam [Lancaster Univ. (United Kingdom). Physics Dept.; Copenhagen Univ. (Denmark). Niels Bohr Inst.

    2010-10-15

    The most important criteria for a successful inflation are to explain the observed temperature anisotropy in the cosmic microwave background radiation, and exiting inflation in a vacuum where it can excite the Standard Model quarks and leptons required for the success of Big Bang Nucleosynthesis. In this paper we provide the first ever closed string model of inflation where the inflaton couplings to hidden sector, moduli sector, and visible sector fields can be computed, showing that inflation can lead to reheating the Standard Model degrees of freedom before the electro-weak scale. (orig.)

  7. Probing the longitudinal momentum spread of the electron wave packet at the tunnel exit

    DEFF Research Database (Denmark)

    N. Pfeiffer, Adrian; Cirelli, Claudio; S. Landsman, Alexandra;

    2012-01-01

    We present an ellipticity resolved study of momentum distributions arising from strong-field ionization of Helium at constant intensity. The influence of the ion potential on the departing electron is considered within a semi-classical model consisting of an initial tunneling step and subsequent...... classical propagation. We find that the momentum distribution can be explained by the presence of a longitudinal momentum spread of the electron at the exit from the tunnel. Our combined experimental and theoretical study provides an estimate of this momentum spread....

  8. The exit from nuclear power in Germany, condition of a real sustainable energy policy

    International Nuclear Information System (INIS)

    We see in this article that it possible to leave nuclear power from a technical, energy and economical point of view in space of one year. If the energy policy is introduced with a long term procedure it means that energy industry and consumers will have a more long time to adapt themselves to a new policy with a priority towards energy saving, cogeneration and renewable energy sources. But it is advisable to notice that the thrust of innovation for the construction of modern power plants, especially in efficient cogeneration will be accordingly lower that the moment of exit will be later. (N.C.)

  9. Estimates of the first Dirichlet eigenvalue from exit time moment spectra

    DEFF Research Database (Denmark)

    Hurtado, Ana; Markvorsen, Steen; Palmer, Vicente

    2013-01-01

    We compute the first Dirichlet eigenvalue of a geodesic ball in a rotationally symmetric model space in terms of the moment spectrum for the Brownian motion exit times from the ball. This expression implies an estimate as exact as you want for the first Dirichlet eigenvalue of a geodesic ball in...... these rotationally symmetric spaces, including the real space forms of constant curvature. As an application of the model space theory we prove lower and upper bounds for the first Dirichlet eigenvalues of extrinsic metric balls in submanifolds of ambient Riemannian spaces which have model space...

  10. Composite fan exit guide vanes for high bypass ratio gas turbine engines

    Science.gov (United States)

    Blecherman, S. S.; Stankunas, T. N.

    1981-01-01

    Various composite materials were identified for reduced weight applications as fan exit guide vanes in high bypass ratio gas turbine engines. Candidate materials, airfoil geometry and ply orientation were evaluated using NASTRAN finite element analysis. A vane core and shell design approach utilizing several different fiber orientation concepts was selected and variations in bending and torsional stiffness were documented. Material suppliers and airfoil fabricators were selected to provide panels and airfoils which were inspected, environmentally conditioned and tested. Static and dynamic airfoil tests established durability characteristics for a range of composite material/design approaches.

  11. Building Letters

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Cabinet是种十分吸引人却很简单的衬线字体,是由一名匿名字体设计师专门为Building Letters最新的资金筹集活动所设计的。这个Building Letters包中包含一个CDROM,有32种字体,以及一本专门设计的杂志和两张由Eboy和Emigre所设计的海报。字体光盘样例是由世界顶级的字体设计师们设计的.

  12. Model Building

    OpenAIRE

    Frampton, Paul H.

    1997-01-01

    In this talk I begin with some general discussion of model building in particle theory, emphasizing the need for motivation and testability. Three illustrative examples are then described. The first is the Left-Right model which provides an explanation for the chirality of quarks and leptons. The second is the 331-model which offers a first step to understanding the three generations of quarks and leptons. Third and last is the SU(15) model which can accommodate the light leptoquarks possibly...

  13. Building economics

    DEFF Research Database (Denmark)

    Pedersen, D.O.(red.)

    Publikationen er på engelsk. Den omfatter alle indlæg på det fjerde internationale symposium om byggeøkonomi, der blev arrangeret af SBI for det internationale byggeforskningsråd CIB. De fem bind omhandler: Methods of Economic Evaluation, Design Optimization, Ressource Utilization, The Building...... Market og Economics and Technological Forecasting in Construction. Et indledende bind bringer statusrapporter for de fem forskningsområder, og det sidste bind sammenfatter debatten på symposiet....

  14. Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.

    Directory of Open Access Journals (Sweden)

    Charles T Miller

    2009-05-01

    Full Text Available Cdc7p-Dbf4p is a conserved protein kinase required for the initiation of DNA replication. The Dbf4p regulatory subunit binds Cdc7p and is essential for Cdc7p kinase activation, however, the N-terminal third of Dbf4p is dispensable for its essential replication activities. Here, we define a short N-terminal Dbf4p region that targets Cdc7p-Dbf4p kinase to Cdc5p, the single Polo kinase in budding yeast that regulates mitotic progression and cytokinesis. Dbf4p mediates an interaction with the Polo substrate-binding domain to inhibit its essential role during mitosis. Although Dbf4p does not inhibit Polo kinase activity, it nonetheless inhibits Polo-mediated activation of the mitotic exit network (MEN, presumably by altering Polo substrate targeting. In addition, although dbf4 mutants defective for interaction with Polo transit S-phase normally, they aberrantly segregate chromosomes following nuclear misorientation. Therefore, Cdc7p-Dbf4p prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint.

  15. Experimental study of pedestrian inflow in a room with a separate entrance and exit

    Science.gov (United States)

    Liu, Xiaodong; Song, Weiguo; Fu, Libi; Fang, Zhiming

    2016-01-01

    Pedestrian inflow process frequently occurs in various pedestrian facilities in our daily life. Great importance should be attached to the study of this process. In this paper, we explore the pedestrian inflow process in a room with a separate entrance and exit. Two kinds of experiments are conducted: experiment 1 has no inactive persons and primarily focuses on analyzing the features of the normal pedestrian inflow process and analyzing the representative spatial parameters in the steady state, while experiment 2 involves the influence of the inactive persons. In order to quantitatively discuss the distribution of pedestrians in the steady state, we adopt several analytical methods, such as the Voronoi diagram method, proxemics, and point pattern analysis. Some features of the inflow process are captured. The distribution of pedestrians in the steady state is not uniform. The proxemics and attraction to the exit are both considered to affect pedestrians' distribution in the inflow process. The presence of inactive persons may have an impact on both the inflow and outflow processes. Practical suggestions are provided for the managers of pedestrian facilities.

  16. Unsteady Flow Variability Driven by Rotor-stator Interaction at Rotor Exit

    Institute of Scientific and Technical Information of China (English)

    ZHAO Ben; YANG Ce; CHEN Shan; QI Mingxu; ZHOU Mi

    2012-01-01

    Numerical investigation of the unsteady flow variability driven by rotor-stator interaction in a transonic axial compressor is performed.Two models with close and far axial gap between rotor and stator rows are studied in the simulation.Particular attention is attached to the analysis of mechanisms involved in driving rotor wake oscillation,rotor wake skewing and flow angle fluctuation at rotor exit.The results show that smaller axial gap is favorable to enhance the interaction in the region between two adjacent rows,and the fluctuation of the static pressure difference between two sides of rotor wake is improved by potential field from down stator,which is the driving force for rotor wake oscillation.The interaction between rotor and stator is weakened by increasing axial distance,rotor wake shifts to suction side of rotor blade with 5%-10% of rotor pitch,the absolute value of flow angle at rotor exit is less than that in the case of close interspace for every time step,and the fluctuation amplitude is also decreased.

  17. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.

    Science.gov (United States)

    Kunda, Patricia; Rodrigues, Nelio T L; Moeendarbary, Emadaldin; Liu, Tao; Ivetic, Aleksandar; Charras, Guillaume; Baum, Buzz

    2012-02-01

    Animal cells undergo dramatic actin-dependent changes in shape as they progress through mitosis; they round up upon mitotic entry and elongate during chromosome segregation before dividing into two [1-3]. Moesin, the sole Drosophila ERM-family protein [4], plays a critical role in this process, through the construction of a stiff, rounded metaphase cortex [5-7]. At mitotic exit, this rigid cortex must be dismantled to allow for anaphase elongation and cytokinesis through the loss of the active pool of phospho-Thr559moesin from cell poles. Here, in an RNA interference (RNAi) screen for phosphatases involved in the temporal and spatial control of moesin, we identify PP1-87B RNAi as having elevated p-moesin levels and reduced cortical compliance. In mitosis, RNAi-induced depletion of PP1-87B or depletion of a conserved noncatalytic PP1 phosphatase subunit Sds22 leads to defects in p-moesin clearance from cell poles at anaphase, a delay in anaphase elongation, together with defects in bipolar anaphase relaxation and cytokinesis. Importantly, similar cortical defects are seen at anaphase following the expression of a constitutively active, phosphomimetic version of moesin. These data reveal a new role for the PP1-87B/Sds22 phosphatase, an important regulator of the metaphase-anaphase transition, in coupling moesin-dependent cell shape changes to mitotic exit.

  18. Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells.

    Science.gov (United States)

    Takeuchi, Hiroki; Takada, Akihiko; Kuboniwa, Masae; Amano, Atsuo

    2016-07-01

    Although human gingival epithelium prevents intrusions by periodontal bacteria, Porphyromonas gingivalis, the most well-known periodontal pathogen, is able to invade gingival epithelial cells and pass through the epithelial barrier into deeper tissues. We previously reported that intracellular P. gingivalis exits from gingival epithelial cells via a recycling pathway. However, the underlying molecular process remains unknown. In the present study, we found that the pathogen localized in early endosomes recruits VAMP2 and Rab4A. VAMP2 was found to be specifically localized in early endosomes, although its localization remained unclear in mammalian cells. A single transmembrane domain of VAMP2 was found to be necessary and sufficient for localizing in early endosomes containing P. gingivalis in gingival epithelial cells. VAMP2 forms a complex with EXOC2/Sec5 and EXOC3/Sec6, whereas Rab4A mediates dissociation of the EXOC complex followed by recruitment of RUFY1/Rabip4, Rab4A effector, and Rab14. Depletion of VAMP2 or Rab4A resulted in accumulation of bacteria in early endosomes and disturbed bacterial exit from infected cells. It is suggested that these novel dynamics allow P. gingivalis to exploit fast recycling pathways promoting further bacterial penetration of gingival tissues.

  19. Simulation study on the effect of pre-evacuation time and exit width on evacuation

    Institute of Scientific and Technical Information of China (English)

    CHU Guanquan; SUN Jinhua; WANG Qingsong; CHEN Sining

    2006-01-01

    Occupant pre-evacuation time is often oversimplified into an explicit value in evacuation calculation. In fact, it is not an explicit value but a random variable following some kind of probability distribution. In order to analyze the importance of pre-evacuation time in evacuation calculation, GridFlow evacuation model is utilized to study the effect of pre-evacuation time on evacuation under different occupant densities and exit widths in a single room scenario. The evacuation time calculated by using normal pre-evacuation distribution is compared with that calculated by explicit pre-evacuation time. Two faults are presented when pre-evacuation time is considered as an explicit value. The theory of congestion and queue is presented to analyze the calculation results. Moreover, this paper also presents probability distribution of the total evacuation time when the pre-evacuation time follows normal distribution. The results show that the evacuation time is dominated by pre-evacuation time and hardly dependent on occupant density when the mean pre- evacuation time is long. For long mean pre-evacua- tion time, low occupant density or wide exit, when pre-evacuation time follows normal distribution, the total evacuation time also follows normal distribution.

  20. Last Glacial - Holocene stratigraphic development at the Marmara Sea exit of the Bosphorus Strait, Turkey

    Science.gov (United States)

    Köprülü, Kerem; Alpar, Bedri; Vardar, Denizhan

    2016-03-01

    High resolution Chirp and Sparker data allowed definition and mapping of distinct seismic units in the shallow sediment record (~100 ms) acquired from the southern exit of the Bosphorus Strait; a dynamic depositional environment. The bottommost unit observed in the Chirp data (unit-3) is made up of marine-lacustrine sediments thinning seaward and onlaps the basement rocks which are represented by folded strata in the Sparker data, possibly lower to middle Pleistocene age. It is overlain by a series of prograding deposits along the shelf (unit-2) referring to sediment input from the northern sector depending on the water levels of the paleo Marmara lake's during MIS 3. The uppermost deposits (unit-1) close to the Bosphorus Strait were represented by three separate subunits, unlike to relatively thin drape of sediments observed at the other places in the surrounding regions. The detailed definition of these subunits deduced from the closely-spaced reflection profiles and available radiocarbon ages helped to explain the history of the latest stratigraphic development depending on the connections between the Black Sea and the Sea of Marmara. In addition to the previously proposed major conduits, which controlled the sedimentary deposition at the southern exit of the Bosphorus, namely the Bosphorus Strait and Kurbağalıdere River, another submarine sedimentary pathway at the eastern bank of the strait's channel seems to have delivered sediments directly into the basin.

  1. Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

    Directory of Open Access Journals (Sweden)

    Vincenzo D'Angiolella

    Full Text Available M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is believed to be particularly crucial in regulating transition into, rather than out of, M-phase. Using the in vitro cell cycle system derived form Xenopus eggs, here we show, however, that inhibitory phosphorylation of cdk1 contributes to control MPF activity during M-phase exit. By sampling extracts at very short intervals during both meiotic and mitotic exit, we found that cyclin B1-associated cdk1 underwent transient inhibitory phosphorylation at tyr-15 and that cyclin B1-cdk1 activity fell more rapidly than the cyclin B1 content. Inhibitory phosphorylation of MPF correlated with phosphorylation changes of cdc25C, the MPF phosphatase, and physical interaction of cdk1 with wee1, the MPF kinase, during M-phase exit. MPF down-regulation required Ca(++/calmodulin-dependent kinase II (CaMKII and cAMP-dependent protein kinase (PKA activities at meiosis and mitosis exit, respectively. Treatment of M-phase extracts with a mutant cyclin B1-cdk1AF complex, refractory to inhibition by phosphorylation, impaired binding of the Anaphase Promoting Complex/Cyclosome (APC/C to its co-activator Cdc20 and altered M-phase exit. Thus, timely M-phase exit requires a tight coupling of proteolysis-dependent and proteolysis-independent mechanisms of MPF inactivation.

  2. Dense water cascading, bottom currents and sediment wave formation at the exit of the Bari canyon (Southern Adriatic Sea, Italy)

    Science.gov (United States)

    Langone, Leonardo; Miserocchi, Stefano; Boldrin, Alfredo; Turchetto, Margherita; Foglini, Federica; Trincardi, Fabio

    2010-05-01

    The dense water forming in the North Adriatic (NAdDW) spreading southward along the Italian continental shelf, sinks in the Southern Adriatic basin through particular cascading events. Such events are seasonal, occurring specially in April, with variable intensity. These phenomena control the water mass mixing, the deep ocean ventilation, the behaviour of deep ecosystems, the formation of complex erosive and depositional bedforms and the abyssal export and burial of nutrients and carbon. Because of the NadDW formation is linked to climate factors (frequency, duration and size of Bura winds), the temporal variations of the NadDW dispersion into the Southern Adriatic allow to make inferences of the impact of recent climate changes on the ecosystems of the deep Mediterranean Sea. Previous research projects (EuroStrataform, HERMES) acquired a large data set of bathymetric, side-scan sonar (TOBI) and Chirp sonar profiles, which were used to build detailed morpho-bathymetric maps of the Southern Adriatic margin. There, the seabed is extremely complex, characterized by a large variety of bedforms (sediment waves, erosive scours, longitudinal furrows and giant comet marks). A branch of the cascading NAdDW is confined and accelerated through the Bari canyon where it produces a strong current capable of reaching down-slope velocities greater than 60 cm s-1 near the bottom at ~600 m of water depth, eroding the canyon thalweg and entraining large amounts of fine-grained sediment. At the exit of the canyon, in water depth greater than 800 m, the current becomes less confined, spreads laterally and generates an 80-km2-wide field of mud waves; these bedforms migrate up current and show amplitudes up to 50 m and wavelengths of about 1 km. Cruise IMPACT-09 of RV Urania was carried out in the Southern Adriatic Sea from 17-30 March 2009 with main scope of studying the impact of NadDW cascading events on the deep ecosystems of the Southern Adriatic. Experiments planned in the cruise

  3. Effectiveness of a Batteryless and Wireless Wearable Sensor System for Identifying Bed and Chair Exits in Healthy Older People

    Directory of Open Access Journals (Sweden)

    Roberto Luis Shinmoto Torres

    2016-04-01

    Full Text Available Aging populations are increasing worldwide and strategies to minimize the impact of falls on older people need to be examined. Falls in hospitals are common and current hospital technological implementations use localized sensors on beds and chairs to alert caregivers of unsupervised patient ambulations; however, such systems have high false alarm rates. We investigate the recognition of bed and chair exits in real-time using a wireless wearable sensor worn by healthy older volunteers. Fourteen healthy older participants joined in supervised trials. They wore a batteryless, lightweight and wireless sensor over their attire and performed a set of broadly scripted activities. We developed a movement monitoring approach for the recognition of bed and chair exits based on a machine learning activity predictor. We investigated the effectiveness of our approach in generating bed and chair exit alerts in two possible clinical deployments (Room 1 and Room 2. The system obtained recall results above 93% (Room 2 and 94% (Room 1 for bed and chair exits, respectively. Precision was >78% and 67%, respectively, while F-score was >84% and 77% for bed and chair exits, respectively. This system has potential for real-time monitoring but further research in the final target population of older people is necessary.

  4. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.

    Science.gov (United States)

    Müllers, Erik; Silva Cascales, Helena; Jaiswal, Himjyot; Saurin, Adrian T; Lindqvist, Arne

    2014-01-01

    Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic inducers, and thus the ability to resume cell division. This permanent cell cycle exit depends on p21, p53, and APC/C(Cdh1). However, when and how permanent cell cycle exit occurs remains unclear. Here, we have investigated the cell cycle response to DNA damage in single cells that express Cyclin B1 fused to eYFP at the endogenous locus. We find that upon DNA damage Cyclin B1-eYFP continues to accumulate up to a threshold level, which is reached only in G2 phase. Above this threshold, a p21 and p53-dependent nuclear translocation required for APC/C(Cdh1)-mediated Cyclin B1-eYFP degradation is initiated. Thus, cell cycle exit is decoupled from activation of the DNA damage response in a manner that correlates to Cyclin B1 levels, suggesting that G2 activities directly feed into the decision for cell cycle exit. Once Cyclin B1-eYFP nuclear translocation occurs, checkpoint inhibition can no longer promote mitotic entry or re-expression of mitotic inducers, suggesting that nuclear translocation of Cyclin B1 marks the restriction point for permanent cell cycle exit in G2 phase.

  5. The comparison of exit-site care with normal saline and povidone-iodine in preventing exit-site infection and peritonitis in children on chronic peritoneal dialysis treatment

    Directory of Open Access Journals (Sweden)

    Onder Yavascan

    2011-01-01

    Full Text Available Peritonitis and catheter exit- site infections (ESI are important causes of hospitalization and catheter loss in patients undergoing chronic peritoneal dialysis (CPD. The frequency of infection can be reduced by scrupulous exit- site care with or without topical antiseptics. There are no studies showing any benefit in the use of povidone-iodine or normal saline for care of exit- sites in long- term CPD patients. In this study, we aimed to determine the potential effectiveness of the application of povidone-iodine or normal saline at the catheter exit- site in preventing ESI and peritonitis in children on CPD. A total of 98 patients treated with either povidone-iodine or normal saline were included in this study. Group I (34 patients used povidone-iodine and group II (64 patients simply cleansed the exit- site with normal saline (0.9% NaCl. Dressings were changed 2 to 3 times in a week. The total cumulative follow- up time was 3233 patient- months. ESIs occurred in 10 (29.4% of 34 patients using povidone-iodine and in 10 (15.6% of 64 patients using normal saline. The frequency of ESI was significantly high in group I (povidone-iodine patients. The mean rate of ESI was 1 episode/60.8 patient- months for group I versus 1 episode/144 patient- months for group II (P 0.05. In conclusion, exit- site care with normal saline is an effective strategy in reducing the incidence of ESI in children on CPD. It can thus significantly reduce morbidity, catheter loss, and the need to transfer patients on peritoneal dialysis to hemodialysis.

  6. Performance comparison of CPCs with and without exit angle restriction for concentrating radiation on solar cells

    International Nuclear Information System (INIS)

    Highlights: • CPCs with and without exit angle restriction based PV modules were fabricated and tested. • Performance of both CPVs was investigated and compared. • Results showed that CPV-65 performed slightly but insignificantly better as compared to CPV-90. - Abstract: To perform this comparison, the compound parabolic concentrator with a restricted exit angle of 65° (CPC-65) and the one without exit angle restriction (CPC-90) were fabricated and tested for concentrating radiation on multi-crystalline solar cells. Both CPC-65 and CPC-90 are identical in the acceptance half-angle (20°) and geometrical concentration factor (2×). Theoretical calculations showed that CPC-90 based PV system (CPV-90) annually concentrated about 3–5% more radiation on solar cells as compared to CPC-65 based PV system (CPV-65). For CPV-65, all radiation would arrive on the solar cells at the incidence angle less than 65°, but for CPV-90, about 8–10% of annual collectible radiation would arrive on solar cells at the incidence angle larger than 65°. Measurements at outdoor conditions showed that the CPV-65 performed slightly better than CPV-90 in terms of short-circuit current and power output as the projection incidence angle of solar rays on the cross-section of CPC-troughs (θp) less than the acceptance half-angle, otherwise the CPV-90 did better. Compared to CPV-90, the power output at maximum power points from CPV-65 were slightly higher, and increases of 2.1%, 5.4% and 8.17% were measured for θp = 0°, 10° and 16°, respectively. Analysis indicated that effect of solar flux distribution over solar cells on power output of both CPVs was almost identical and insignificant, and the CPV-65 performed slightly but insignificantly better than the CPV-90 in terms of annual power output except in areas with poor solar resources where the annual power output from both systems was almost identical

  7. Mitotic Exit Function of Polo-like Kinase Cdc5 Is Dependent on Sequential Activation by Cdk1

    Directory of Open Access Journals (Sweden)

    Jose-Antonio Rodriguez-Rodriguez

    2016-05-01

    Full Text Available To complete mitosis, Saccharomyces cerevisiae needs to activate the mitotic phosphatase Cdc14. Two pathways contribute to Cdc14 regulation: FEAR (Cdc14 early anaphase release and MEN (mitotic exit network. Cdc5 polo-like kinase was found to be an important mitotic exit component. However, its specific role in mitotic exit regulation and its involvement in Cdc14 release remain unclear. Here, we provide insight into the mechanism by which Cdc5 contributes to the timely release of Cdc14. Our genetic and biochemical data indicate that Cdc5 acts in parallel with MEN during anaphase. This MEN-independent Cdc5 function requires active separase and activation by Cdk1-dependent phosphorylation. Cdk1 first phosphorylates Cdc5 to activate it in early anaphase, and then, in late anaphase, further phosphorylation of Cdc5 by Cdk1 is needed to promote its MEN-related functions.

  8. A time-compressed simulated geomagnetic storm influences the nest-exiting flight angles of the stingless bee Tetragonisca angustula.

    Science.gov (United States)

    Esquivel, D M S; Corrêa, A A C; Vaillant, O S; de Melo, V Bandeira; Gouvêa, G S; Ferreira, C G; Ferreira, T A; Wajnberg, E

    2014-03-01

    Insects have been used as models for understanding animal orientation. It is well accepted that social insects such as honeybees and ants use different natural cues in their orientation mechanism. A magnetic sensitivity was suggested for the stingless bee Schwarziana quadripunctata, based on the observation of a surprising effect of a geomagnetic storm on the nest-exiting flight angles. Stimulated by this result, in this paper, the effects of a time-compressed simulated geomagnetic storm (TC-SGS) on the nest-exiting flight angles of another stingless bee, Tetragonisca angustula, are presented. Under an applied SGS, either on the horizontal or vertical component of the geomagnetic field, both nest-exiting flight angles, dip and azimuth, are statistically different from those under geomagnetic conditions. The angular dependence of ferromagnetic resonance (FMR) spectra of whole stingless bees shows the presence of organized magnetic nanoparticles in their bodies, which indicates this material as a possible magnetic detector.

  9. Do host country education and language training help recent immigrants exit poverty?

    Science.gov (United States)

    Kaida, Lisa

    2013-05-01

    Despite growing interest in host country-specific skills, quantitative assessments of the economic benefit of host country education and training for immigrants are limited. This study addresses this gap by evaluating the impacts of host country formal education and language training on the exit from family poverty among recently arrived immigrant adults. The bivariate probit model and propensity weighting approach are used to analyze data from the Longitudinal Survey of Immigrants to Canada. Results suggest that while English/French language training is beneficial for low income recent immigrants in general, host country education benefits only highly educated recent arrivals. This study underscores the importance of considering immigrants' selectivity into host country education and training, as simple regression analysis can improperly estimate their true benefits. PMID:23521991

  10. A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel

    DEFF Research Database (Denmark)

    Long, Katherine S; Porse, Bo T

    2003-01-01

    The antibiotic chloramphenicol produces modifications in 23S rRNA when bound to ribosomes from the bacterium Escherichia coli and the archaeon Halobacterium halobium and irradiated with 365 nm light. The modifications map to nucleotides m(5)U747 and C2611/C2612, in domains II and V, respectively......, of E.coli 23S rRNA and G2084 (2058 in E.coli numbering) in domain V of H.halobium 23S rRNA. The modification sites overlap with a portion of the macrolide binding site and cluster at the entrance to the peptide exit tunnel. The data correlate with the recently reported chloramphenicol binding site on...

  11. Characterization of Carbon Particulates in the Exit Flow of a Plasma Pyrolysis Assembly (PPA) Reactor

    Science.gov (United States)

    Green, Robert D.; Meyer, Marit E.; Agui, Juan H.; Berger, Gordon M.; Vijayakumar, R.; Abney, Morgan B.; Greenwood, Zachary

    2015-01-01

    The ISS presently recovers oxygen from crew respiration via a Carbon Dioxide Reduction Assembly (CRA) that utilizes the Sabatier chemical process to reduce captured carbon dioxide to methane (CH4) and water. In order to recover more of the hydrogen from the methane and increase oxygen recovery, NASA Marshall Space Flight Center (MSFC) is investigating a technology, plasma pyrolysis, to convert the methane to acetylene. The Plasma Pyrolysis Assembly (or PPA), achieves 90% or greater conversion efficiency, but a small amount of solid carbon particulates are generated as a side product and must be filtered before the acetylene is removed and the hydrogen-rich gas stream is recycled back to the CRA. In this work, we present the experimental results of an initial characterization of the carbon particulates in the PPA exit gas stream. We also present several potential options to remove these carbon particulates via carbon traps and filters to minimize resupply mass and required downtime for regeneration.

  12. SNM monitor applications: diversion safeguards for emergency exits and detection of undeclared feed in enrichment plants

    International Nuclear Information System (INIS)

    A new monitor for special nuclear material (SNM) uses wide plastic scintillators and digital logic to achieve a higher sensitivity for detecting uranium than is found in conventional personnel SNM monitors. With its detectors spaced 2 m apart, the new monitor meets the DOE requirement to detect a 10-g metal 235U sphere of 93% 235U whose total mass is 10.8 g. This capability suits the monitor to scan people who may have to pass quickly through emergency exits. In yet another application, the monitor meets detection goals for detecting freshly separated, natural UF6 that is brought into enrichment plants through personnel portals. To determine the performance of the new monitor for these applications, laboratory source scans and measurements of the growth of uranium daughter activity in freshly separated UF6 were used

  13. Motivating signage prompts safety belt use among drivers exiting senior communities.

    Science.gov (United States)

    Cox, B S; Cox, A B; Cox, D J

    2000-01-01

    Senior drivers are vulnerable to automobile crashes and subsequent injury and death. Safety belts reduce health risks associated with auto crashes. Therefore, it is important to encourage senior drivers to wear safety belts while driving. Using an AB design, replicated five times, we evaluated the short- and long-term effects of a sign with the message "BUCKLE UP, STAY SAFE" attached to a stop sign at the exits of five different senior communities. Safety belt use was stable during two pretreatment assessments averaged across the five sites and 250 drivers (72% and 68% usage), but significantly increased following installation of these signs (94% usage). Six months after installation of the signs, the effect persisted (88% usage). Use of such signs may be a cost-effective way of promoting safety belt use.

  14. The Effect of Sanctions and Active Labour Market Programmes on the Exit Rate From Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar; Svarer, Michael

    2009-01-01

    ). Hence, modeling only one of them as treatment might over or underestimate the true effect. Therefore, by using a multivariate mixed proportional hazard model (MMPH), we model the hazard rate out of unemployment along with the sanction rate and hazard rate into active labour market programmes. We......This paper simultaneously investigates the effectiveness of benefit sanctions and active labour market programmes on the exit rate from unemployment using Danish data. In the data about one third of the individuals who are sanctioned also participate in some active labour market programmes (ALMPs...... optimally select the number of supports point for the distribution of unobserved heterogeneity. Results show that pre-specifying two support points underestimates the effect of sanctions and active labour market programmes. Failing to control for selectivity for sanctions not only underestimates...

  15. Blade-to-Blade Flow at Centrifugal Impeller Exit Under Rotating Stall

    Science.gov (United States)

    Shin, You Hwan; Kim, Kwang Ho

    This study presents the unsteady fluctuation measurements of impeller discharge flow for a centrifugal compressor in unstable operating region. The characteristics of the blade-to-blade flow under rotating stall were investigated by measuring unsteady velocity fluctuations at several different diffuser axial distances using a hot wire anemometer and high frequency pressure transducers mounted on the shroud wall. The flow characteristics in terms of the radial and tangential velocity components and turbulence intensity at the impeller exit were analyzed by using double phase-locked ensemble averaging techniques. During one stall period, a deep wake core was observed on the suction surface near the hub for the maximum radial velocity instant. On the other hand, large wake region existed in the middle of the passage near the shroud side. For the radial velocity increasing instant a quite strong core flow was generated at the pressure side, however, for the decreasing instant comparatively strong core flow was developed near the suction side.

  16. INVESTIGATION OF VISITOR MOTIVATION OF THE EXIT MUSIC FESTIVAL (THE REPUBLIC OF SERBIA

    Directory of Open Access Journals (Sweden)

    Ivana BLEŠIĆ

    2014-12-01

    Full Text Available The decision to visit a festival or an event is a directed activity initiated by a wish to fulfil certain cultural need. Although motives only represent one of the variables describing visitor behaviour (besides learning, cultural conditioning and social influences, they form a crucial point that initiates decision making. The purpose of this study was to develop a measurement instrument that can be used to measure the most significant festival motivators for visitors’ travels to music festivals. The paper delivers the results of a questionnaire research conducted during the 11th EXIT festival (Petrovaradin Fortress, Novi Sad, The Republic of Serbia in July 2011. The results were based on 566 questionnaires. The factor analysis generated three items: socialization; exploration of the festival programme and atmosphere; and perception of the festival and learning.

  17. 1-40-keV fixed-exit monochromator for a wafer mapping TXRF facility

    Science.gov (United States)

    Comin, Fabio; Apostolo, G.; Freund, Andreas K.; Mangiagalli, P.; Navizet, M.; Troxel, C. L.

    1998-12-01

    An industrial facility for the mapping of trace impurities on the surface of 300 mm Silicon wafers will be commissioned at the end of 1998. The elements to be detected range from Na to Hg with a target routine detection limit of 108 atoms/cm2. The monochromator of the facility plays a central role and fulfills the following requirements: ease of operations and fast tuning (one single motor); extended energy range (1 - 40 KeV covered by a fixed exit Si(111) channel cut and multilayer pair); smooth and reliable running (water cooling even in the powerful ESRF undulator beams at high energies). The mechanical structure of the monochromator is based on well-established concepts: an external goniometer transfers the main rotation to the in-vacuum plateau via a hollow differentially pumped feed-through. The optical arrangement shows some novelties: the plateau can be cooled either by water or liquid nitrogen and it holds the convex- concave machined Si(111) channel-cut for fixed exit performances. The shape of the machined surfaces of the crystal helps also on to spread the power density of the beam on the silicon surface. A set of two identical multilayers are also mounted on the plateau and the transition from the Si(111) crystal to the multilayer operation is performed by rotating the wafer main axis by about 180 degrees. The whole facility is centered around the three main components: the monochromator, the wafer handling robots and the two linear arrays of solid state fluorescence detectors.

  18. Pid Plus Fuzzy Logic Controller Based Electronic Load Controller For Self Exited Induction Generator.

    Directory of Open Access Journals (Sweden)

    S.Swathi,

    2014-01-01

    Full Text Available This paper deals with the electronic load controller for self exited induction generator using PID plus fuzzy logic controller. The self-excited induction generators (SEIGs are considered to be well suited for generating electricity by means of conventional energy sources and for supplying electrical energy in remote and rural areas. Induction generators have many advantages such as cost, reduced maintenance, rugged, and simple construction, brushless rotor (squirrel cage. A three phase induction generator can be operated on a delta connection for supplying single phase loads. The main disadvantage of SEIG has is that it poor voltage regulation, and its value depends on the prime mover speed, capacitance, load current and power factor of the load. The electronic load controller (ELC can be used for maintaining constant voltage and frequency of SEIG with variable consumer load driven by constant prime mover. This paper presents the simulation design and implementation of ELC using fuzzy logic method for an SEIG feeding single-phase load. The ELC consist of a rectifier, IGBT as a chopper switch, PI controller, voltage sensor, and resistive dump load in which power consumption was varied through the duty cycle of the chopper. However an ELC consist of electronics system, in general, has complex nonlinear model with parameter variation problem, and the control need to be very fast. The fuzzy logic based controller gives nonlinear control with fast response and virtually no overshoot. The simulation of ELC for self exited induction generator is carried out on MATLAB/SIMULINK. By this proposed ELC using FLC for SEIG we can maintain the constant voltage and frequency of SEIG with variable consumer load.

  19. Educational Inequalities in Exit from Paid Employment among Dutch Workers: The Influence of Health, Lifestyle and Work.

    Directory of Open Access Journals (Sweden)

    Suzan J W Robroek

    Full Text Available Individuals with lower socioeconomic status are at increased risk of involuntary exit from paid employment. To give sound advice for primary prevention in the workforce, insight is needed into the role of mediating factors between socioeconomic status and labour force participation. Therefore, it is aimed to investigate the influence of health status, lifestyle-related factors and work characteristics on educational differences in exit from paid employment.14,708 Dutch employees participated in a ten-year follow-up study during 1999-2008. At baseline, education, self-perceived health, lifestyle (smoking, alcohol, sports, BMI and psychosocial (demands, control, rewards and physical work characteristics were measured by questionnaire. Employment status was ascertained monthly based on tax records. The relation between education, health, lifestyle, work-characteristics and exit from paid employment through disability benefits, unemployment, early retirement and economic inactivity was investigated by competing risks regression analyses. The mediating effects of these factors on educational differences in exit from paid employment were tested using a stepwise approach.Lower educated workers were more likely to exit paid employment through disability benefits (SHR:1.84, unemployment (SHR:1.74, and economic inactivity (SHR:1.53 but not due to early retirement (SHR:0.92. Poor or moderate health, an unhealthy lifestyle, and unfavourable work characteristics were associated with disability benefits and unemployment, and an unhealthy lifestyle with economic inactivity. Educational differences in disability benefits were explained for 40% by health, 31% by lifestyle, and 12% by work characteristics. For economic inactivity and unemployment, up to 14% and 21% of the educational differences could be explained, particularly by lifestyle-related factors.There are educational differences in exit from paid employment, which are partly mediated by health

  20. Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.

    Directory of Open Access Journals (Sweden)

    Christopher M Yellman

    Full Text Available Cdc14 phosphatase is a key regulator of exit from mitosis, acting primarily through antagonism of cyclin-dependent kinase, and is also thought to be important for meiosis. Cdc14 is released from its sequestration site in the nucleolus in two stages, first by the non-essential Cdc Fourteen Early Anaphase Release (FEAR pathway and later by the essential Mitotic Exit Network (MEN, which drives efficient export of Cdc14 to the cytoplasm. We find that Cdc14 is confined to the nucleus during early mitotic anaphase release, and during its meiosis I release. Proteins whose degradation is directed by Cdc14 as a requirement for mitotic exit (e.g. the B-type cyclin, Clb2, remain stable during mitotic FEAR, a result consistent with Cdc14 being restricted to the nucleus and not participating directly in mitotic exit. Cdc14 released by the FEAR pathway has been proposed to have a wide variety of activities, all of which are thought to promote passage through anaphase. Proposed functions of FEAR include stabilization of anaphase spindles, resolution of the rDNA to allow its segregation, and priming of the MEN so that mitotic exit can occur promptly and efficiently. We tested the model for FEAR functions using the FEAR-deficient mutation net1-6cdk. Our cytological observations indicate that, contrary to the current model, FEAR is fully dispensable for timely progression through a series of anaphase landmarks and mitotic exit, although it is required for timely rDNA segregation. The net1-6cdk mutation suppresses temperature-sensitive mutations in MEN genes, suggesting that rather than activating mitotic exit, FEAR either inhibits the MEN or has no direct effect upon it. One interpretation of this result is that FEAR delays MEN activation to ensure that rDNA segregation occurs before mitotic exit. Our findings clarify the distinction between FEAR and MEN-dependent Cdc14 activities and will help guide emerging quantitative models of this cell cycle transition.

  1. Building energy analysis tool

    Science.gov (United States)

    Brackney, Larry; Parker, Andrew; Long, Nicholas; Metzger, Ian; Dean, Jesse; Lisell, Lars

    2016-04-12

    A building energy analysis system includes a building component library configured to store a plurality of building components, a modeling tool configured to access the building component library and create a building model of a building under analysis using building spatial data and using selected building components of the plurality of building components stored in the building component library, a building analysis engine configured to operate the building model and generate a baseline energy model of the building under analysis and further configured to apply one or more energy conservation measures to the baseline energy model in order to generate one or more corresponding optimized energy models, and a recommendation tool configured to assess the one or more optimized energy models against the baseline energy model and generate recommendations for substitute building components or modifications.

  2. The Impact of Statewide Exit Exams: A Descriptive Case Study of Three German States with Differing Low Stakes Exam Regimes

    Science.gov (United States)

    van Ackeren, Isabell; Block, Rainer; Klein, E. Dominique; Kuhn, Svenja M.

    2012-01-01

    In this article we present results from a study investigating the impact of three state exit exam systems on teaching and learning in college-preparatory schools. The study compares one state with a traditionally more centralized exam regime, one state that is more de-centralized and one state that has recently switched to more centralized…

  3. Assessing the Impact of Education and Marriage on Labor Market Exit Decisions of Women. Working Paper 2010-2

    Science.gov (United States)

    Hotchkiss, Julie L.; Pitts, M. Melinda; Walker, Mary Beth

    2010-01-01

    During the late 1990s, the convergence of women's labor force participation rates to men's rates came to a halt. This paper explores the degree to which the role of education and marriage in women's labor supply decisions also changed over this time period. Specifically, this paper investigates women's decisions to exit the labor market upon the…

  4. Comparison of experimental hut entrance and exit behavior between Anopheles darlingi from the Cayo District, Belize, and Zungarococha, Peru.

    Science.gov (United States)

    Sachs, Paige; Diaz Rodriguez, Gloria Alicia; Briceno, Ireneo; King, Russell; Achee, Nicole L; Grieco, John P

    2013-12-01

    Anopheles darlingi is a major vector for malaria in Central and South America. Behavioral, ecological, genetic, and morphologic variability has been observed across its wide distribution. Recent studies have documented that 2 distinct genotypes exist for An. darlingi: a northern lineage (Belize, Guatemala, Colombia, Venezuela, and Panama) and a southern lineage (Amazonia and southern Brazil). In order to determine if these genotypes exhibited different behavioral traits, entrance and exit movement patterns between 2 field populations of An. darlingi that represented each genotype were evaluated using experimental huts. The Belize population exhibited bimodal entrance, with peak entry occurring between 7:00-8:00 p.m. and 5:00-6:00 a.m. and peak exiting occurring between 7:00-8:00 p.m. The Peru population exhibited unimodal entrance, with peak entry occurring between 10:00-11:00 p.m. and peak exiting occurring between 11:00-12:00 a.m. with a secondary smaller peak at 2:30 a.m. Entrance and exit behavioral patterns were significantly different between the Belize and Peru populations of An. darlingi (log-rank [Mantel-Cox] P < 0.001). Information from the present study will be used in the future to determine if there is a correlation between genotype and host-seeking behavior and can be used in the present for regional vector risk assessment.

  5. Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast.

    Science.gov (United States)

    Hatano, Yuhki; Naoki, Koike; Suzuki, Asuka; Ushimaru, Takashi

    2016-10-01

    The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anaphase transition and the remaining molecules are still present in anaphase. The roles of securin and separase in late mitosis remain elusive. Here, we show that securin still inhibits separase to repress mitotic exit in anaphase in budding yeast. APC/C-Cdh1-mediated securin degradation at telophase further liberated separase, which promotes Cdc14 release and mitotic exit. Separase executed these events via its proteolytic action and that in the Cdc14 early release (FEAR) network. Cdc14 release further activated APC/C-Cdh1 in the manner of a positive feedback loop. Thus, the positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis. This study shows the importance of the two-step degradation mode of securin and the role of separase in mitotic exit.

  6. 47 CFR 64.1330 - State review of payphone entry and exit regulations and public interest payphones.

    Science.gov (United States)

    2010-10-01

    ... regulations and public interest payphones. 64.1330 Section 64.1330 Telecommunication FEDERAL COMMUNICATIONS... its rules and policies to determine whether it has provided for public interest payphones consistent... Provision of Payphone Service § 64.1330 State review of payphone entry and exit regulations and...

  7. Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast.

    Science.gov (United States)

    Hatano, Yuhki; Naoki, Koike; Suzuki, Asuka; Ushimaru, Takashi

    2016-10-01

    The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anaphase transition and the remaining molecules are still present in anaphase. The roles of securin and separase in late mitosis remain elusive. Here, we show that securin still inhibits separase to repress mitotic exit in anaphase in budding yeast. APC/C-Cdh1-mediated securin degradation at telophase further liberated separase, which promotes Cdc14 release and mitotic exit. Separase executed these events via its proteolytic action and that in the Cdc14 early release (FEAR) network. Cdc14 release further activated APC/C-Cdh1 in the manner of a positive feedback loop. Thus, the positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis. This study shows the importance of the two-step degradation mode of securin and the role of separase in mitotic exit. PMID:27418100

  8. An Examination of the Job Training and Job Experiences of High School Students as They Exit School

    Science.gov (United States)

    Andrews, Wilbur Drew

    2010-01-01

    The purpose of this investigation was (a) to determine the level of satisfaction that exiting high school students felt regarding the job preparation and training they received in high school, (b) gather data on work experiences during high school, (c) gather data on job training experiences during high school, and (d) gather data on students…

  9. Closing the Academic Achievement Gap on the California High School Exit Exam (CAHSEE) through Professional Learning Communities (PLC) Characteristics

    Science.gov (United States)

    Buenrostro, Samuel

    2012-01-01

    Purpose: The purpose of this study was to determine the degree of importance that DuFour's nine characteristics of highly effective schools have on closing the academic achievement gap on the California High School Exit Exam, as perceived by high school principals. The study also examined the strategies believed to be most important in…

  10. Clearance of emergency exits for use by the elderly, a proposal for an addition to a Dutch standard

    NARCIS (Netherlands)

    Voorbij, A.I.M.; Steenbekkers, L.P.A.; Snijders, C.J.

    1999-01-01

    The maximum pulling and pushing forces of a sample of 750 persons between 20 and 30 and over 50 years of age are presented. Both forces were measured in a free standing position that was related to opening a heavy door, which makes it possible to use the information in a standard on emergency exits.

  11. Using Hirschman's Concept of Exit, Voice, and Loyalty To Understand Public Response to the Charter School Movement.

    Science.gov (United States)

    King, Dan L.; Taylor-King, Sheila

    When consumers perceive a lessening in the value of any particular good or service provided by a free-market private enterprise, the likelihood of exit (that is, their choice of an alternative provider) is high. Parents of students enrolled in public schools, on the other hand, typically have not been able to choose an alternative service…

  12. The Fire-Alarm Game: Exit Training Using Negative and Positive Reinforcement under Varied Stimulus Conditions. Short Reports.

    Science.gov (United States)

    Holburn, C. Steven; Dougher, Michael J.

    1985-01-01

    Techniques for training a severely retarded blind client to exit his living unit during a fire drill used a combination of negative and positive reinforcement. Following a shaping procedure, the client learned to leave his living unit from any internal point through generalization training and subsequent test probes. (Author/CL)

  13. Turbulent fluid-structure interaction of water-entry/exit of a rotating circular cylinder using SPH method

    Science.gov (United States)

    Ghazanfarian, Jafar; Saghatchi, Roozbeh; Gorji-Bandpy, Mofid

    2015-12-01

    This paper studies the two-dimensional (2D) water-entry and exit of a rotating circular cylinder using the Sub-Particle Scale (SPS) turbulence model of a Lagrangian particle-based Smoothed-Particle Hydrodynamics (SPH) method. The full Navier-Stokes (NS) equations along with the continuity have been solved as the governing equations of the problem. The accuracy of the numerical code is verified using the case of water-entry and exit of a nonrotating circular cylinder. The numerical simulations of water-entry and exit of the rotating circular cylinder are performed at Froude numbers of 2, 5, 8, and specific gravities of 0.25, 0.5, 0.75, 1, 1.75, rotating at the dimensionless rates of 0, 0.25, 0.5, 0.75. The effect of governing parameters and vortex shedding behind the cylinder on the trajectory curves, velocity components in the flow field, and the deformation of free surface for both cases have been investigated in detail. It is seen that the rotation has a great effect on the curvature of the trajectory path and velocity components in water-entry and exit cases due to the interaction of imposed lift and drag forces with the inertia force.

  14. Unexpected Up/Down asymmetry measured in axial radiation exiting high-temperature dynamic-hohlraum x-ray source

    Science.gov (United States)

    Sanford, T. W. L.; Lemke, R. W.; Mock, R. C.; Oliver, B. V.; Chandler, G. A.; Leeper, R. J.; Mehlhorn, T. A.; Nash, T. J.; Ruiz, C. L.; Waisman, E. M.; Peterson, D. L.; Chrien, R. E.; Idzorek, G. C.; Watt, R. G.; Roderick, N. F.; Haines, M. G.

    2002-11-01

    A 10 TW radiation source has been developed on the 20-MA Z facility that produces a high-temperature ( 215 eV) x-ray pulse. The pulse is generated in the positive z-direction through a REH (radiation exit hole), primarily from the interior of a collapsing dynamic-hohlraum (DH) centered within a z-pinch [1]. By adding an identical REH at the bottom of the hohlraum, radiation generated in the negative z direction through the bottom offers the possibility of doubling the utility of the hohlraum. Because of the up/down symmetry of the DH about the mid-plane of the z-axis (aside from the power feed), a radiation pulse similar to that exiting the top-REH (anode) is expected leaving the bottom-REH (cathode). Measurements indicate, however, that the peak radiated power exiting the top-REH is 2±0.2 times that exiting the bottom-REH. In contrast, the total energy radiated from either REH is about the same. Detailed measurements of this unexpected asymmetry, apparently dependent on polarity, together with potential origins of the asymmetry are discussed. [1] T. W. L. Sanford, et al, in press, Phys. Plasmas 9, (Aug. 2002). *Sandia is a multi-program laboratory operated by the Sandia Corporation, a Lockheed Martin Company, for the U.S. DOE under Contract No. DE-AC04-94AL85000.

  15. Educational inequalities in exit from paid employment among Dutch workers: The influence of health, lifestyle and work

    NARCIS (Netherlands)

    S.J.W. Robroek (Suzan); A. Rongen (Anne); C.H. Arts (Coos); Otten, F.W.H. (Ferdy W.H.); A. Burdorf (Alex); M. Schuring (Merel)

    2015-01-01

    textabstractBackground Individuals with lower socioeconomic status are at increased risk of involuntary exit from paid employment. To give sound advice for primary prevention in the workforce, insight is needed into the role of mediating factors between socioeconomic status and labour force particip

  16. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    Builders generally use a 'spec and purchase' business management system (BMS) when implementing energy efficiency. A BMS is the overall operational and organizational systems and strategies that a builder uses to set up and run its company. This type of BMS treats building performance as a simple technology swap (e.g. a tank water heater to a tankless water heater) and typically compartmentalizes energy efficiency within one or two groups in the organization (e.g. purchasing and construction). While certain tools, such as details, checklists, and scopes of work, can assist builders in managing the quality of the construction of higher performance homes, they do nothing to address the underlying operational strategies and issues related to change management that builders face when they make high performance homes a core part of their mission. To achieve the systems integration necessary for attaining 40% + levels of energy efficiency, while capturing the cost tradeoffs, builders must use a 'systems approach' BMS, rather than a 'spec and purchase' BMS. The following attributes are inherent in a systems approach BMS; they are also generally seen in quality management systems (QMS), such as the National Housing Quality Certification program: Cultural and corporate alignment, Clear intent for quality and performance, Increased collaboration across internal and external teams, Better communication practices and systems, Disciplined approach to quality control, Measurement and verification of performance, Continuous feedback and improvement, and Whole house integrated design and specification.

  17. 3D TOPOLOGICAL INDOOR BUILDING MODELING INTEGRATED WITH OPEN STREET MAP

    Directory of Open Access Journals (Sweden)

    A. Jamali

    2016-09-01

    Full Text Available Considering various fields of applications for building surveying and various demands, geometry representation of a building is the most crucial aspect of a building survey. The interiors of the buildings need to be described along with the relative locations of the rooms, corridors, doors and exits in many kinds of emergency response, such as fire, bombs, smoke, and pollution. Topological representation is a challenging task within the Geography Information Science (GIS environment, as the data structures required to express these relationships are particularly difficult to develop. Even within the Computer Aided Design (CAD community, the structures for expressing the relationships between adjacent building parts are complex and often incomplete. In this paper, an integration of 3D topological indoor building modeling in Dual Half Edge (DHE data structure and outdoor navigation network from Open Street Map (OSM is presented.

  18. THE RELEVANCE OF MACNEIL'S RELATIONAL NORMS TO UNDERSTAND THE EXIT OF A INTERORGANIZATIONAL RELATIONSHIP

    OpenAIRE

    Prim-Allaz, Isabelle; Perrien, Jean

    2000-01-01

    Relationship marketing has been gaining an increasing interest in the marketing community for the past ten years. Some authors define relationship building and management as the core of the marketing process (Grönroos, 1994), others view it as a way to build up effective competitive advantages especially when potential for differentiation is weak, such as in services (e.g., Day, 2000). Although the volume of conceptual and empirical researches on relationship marketing is impressive, few atte...

  19. Water exit pathways and proton pumping mechanism in B-type cytochrome c oxidase from molecular dynamics simulations.

    Science.gov (United States)

    Yang, Longhua; Skjevik, Åge A; Han Du, Wen-Ge; Noodleman, Louis; Walker, Ross C; Götz, Andreas W

    2016-09-01

    Cytochrome c oxidase (CcO) is a vital enzyme that catalyzes the reduction of molecular oxygen to water and pumps protons across mitochondrial and bacterial membranes. While proton uptake channels as well as water exit channels have been identified for A-type CcOs, the means by which water and protons exit B-type CcOs remain unclear. In this work, we investigate potential mechanisms for proton transport above the dinuclear center (DNC) in ba3-type CcO of Thermus thermophilus. Using long-time scale, all-atom molecular dynamics (MD) simulations for several relevant protonation states, we identify a potential mechanism for proton transport that involves propionate A of the active site heme a3 and residues Asp372, His376 and Glu126(II), with residue His376 acting as the proton-loading site. The proposed proton transport process involves a rotation of residue His376 and is in line with experimental findings. We also demonstrate how the strength of the salt bridge between residues Arg225 and Asp287 depends on the protonation state and that this salt bridge is unlikely to act as a simple electrostatic gate that prevents proton backflow. We identify two water exit pathways that connect the water pool above the DNC to the outer P-side of the membrane, which can potentially also act as proton exit transport pathways. Importantly, these water exit pathways can be blocked by narrowing the entrance channel between residues Gln151(II) and Arg449/Arg450 or by obstructing the entrance through a conformational change of residue Tyr136, respectively, both of which seem to be affected by protonation of residue His376. PMID:27317965

  20. Building trust

    International Nuclear Information System (INIS)

    'Activate' is the energy magazine for secondary schools and is part of the Education Programme which is managed on behalf of the British Nuclear Industry Forum by AEA Technology. activate is the flagship communication device between the British Nuclear Industry Forum's Education Programme and secondary schools in the UK. It was developed from a previous publication, Nuclear Bulletin. There is a need for the nuclear industry to build trust with teachers and students in the UK, where for a long time, everything that the industry has said, written or printed has been disregarded by school teachers as propaganda. Over the last few years the industry has put in a great deal of effort to position itself as a provider of educationally sound and socially acceptable information. 'Activate' was an evolution of this idea and there was a hole in the market for a lively, activity and article based magazine that could be used in the classroom. The target audience is principally teachers of science, mathematics and geography, but also includes teachers of art,, English and history with students of between 11 and 18. The results were very positive in that teachers appreciated the colourful and lively nature of activate and they felt that it provided information and opinions in an un biased and non-propagandist way. Their comments about layout, number of activities style of presentation were taken into account and during the summer of 1994 activate was remodelled ready for re launch in September. The feedback so far is good with more teachers signing up every week to receive their own free copy

  1. Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes.

    Science.gov (United States)

    de Castro, M A G; Bunt, G; Wouters, F S

    2016-01-01

    The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic outcomes. As the substrate spectrum of lysosomal proteases encompasses the apoptosis-regulating proteins of the Bcl-2 family, their degradation could influence the cell death outcome upon lysosomal disruption. We used Förster resonance energy transfer (FRET)-based biosensors to image the real-time degradation of the Bcl-2-family members, Bcl-xl, Bax and Bid, in living cells undergoing lysosomal lysis and identified an early chain of proteolytic events, initiated by the release of cathepsin B, which directs cells toward apoptosis. In this apoptotic exit strategy, cathepsin B's proteolytic activity results in apoptosis-inducing Bid and removes apoptosis-preventing Bcl-xl. Cathepsin B furthermore appears to degrade a cystein protease that would otherwise have eliminated apoptosis-supporting Bax, indirectly keeping cellular levels of the Bax protein up. The concerted effort of these three early events shifts the balance of cell fate away from necrosis and toward apoptosis. PMID:27551506

  2. Application of Core Exit Temperature for Effective Safety Injection Strategy of Severe Accident Management Guidance

    International Nuclear Information System (INIS)

    Due to limited time for operator's action under the postulated severe accident, immediate and short term actions are needed and relevant strategies are constructed in the SAMG. Therefore, the SAMG includes a variety of information to assist the proper operator actions. Among these, pre-calculated graphs and formulas facilitate understanding of plant status and operator's action needed for accident mitigation. These are essential for ease of application and regarded as Computational Aids (CA). The representative example is the estimation of injection flow rates for removing decay heat and oxidation heat of core, and hydrogen generation rate, to mention a few. Most of all, calculation of the necessary injection flow rate is important in order to mitigate and/or terminate core damages. In estimating the flow rate for accident mitigation, Core Exit Temperature (CET) is utilized as a key variable. CET is considered most effective and reliable means for diagnosing core state. As such, CET has been adopted as a criterion transitioning from EOPs to SAMG. In this study, the necessary flow rate is calculated utilizing simple model with CET for RCS injection in mitigation strategy of SAMG. MELCOR simulation results are introduced for the calculation. A simple model of flow rate necessary for core heat removal is developed using CET data obtained from MELCOR simulations of OPR1000. The suggested model is expected to contribute on judging the core state in its coolability and required flow injection due to ease of application. More detailed analyses are needed to normalize by including additional accident scenarios

  3. Some Aspects of Exit of Ukraine’s Economy from the Crisis

    Directory of Open Access Journals (Sweden)

    Bulyeyev Ivan P.

    2016-02-01

    Full Text Available The analysis of trends both in the global and Ukraine’s economy demonstrates a cyclic, non-linear character of these processes under conditions of absence of a unifying national idea in Ukraine, ignoring institutional features. Ukraine chose a catch-up model of development having not formed corresponding institutions, its own scientific and methodological base, the public-minded elite. The aim of the work is theoretical substantiation of institutional environment contributing to the exit of the economy, industry and business entities from the systemic social and economic crisis. It is necessary: to formulate the goal of the society, its main classes, its elite for a medium term; reconsider the fundamental values of the society; determine the main directions in the development of the economy, industry, social sphere; move from the catch-up strategy to the point advanced one; ensure reduction of the gap in income of extreme decile groups of the population; support fundamental science, education, health care; provide a total increase of the responsibility of managers at all levels on the basis of contracts, programs, roadmaps, monitoring their performance

  4. Effects of the geometry of the exit of a tube in an oscillating flow

    Science.gov (United States)

    Echeverría, Elia; Málaga, Carlos; Czitrom, Steven; Olvera, Arturo; Stern, Catalina

    2014-11-01

    The problem of optimizing the performance of a wave-driven seawater pump - comprising a resonant duct and an exhaust duct joined by a variable volume air-compression chamber - it is explored by studying oscillating flows at the exit of a tube. It is known that the performance of this pump depends on the geometry of the mouth of its intake tube. An inspection of the integral expression of the Navier-Stokes equation along a central streamline of this flow shows that changing the shape of the tube's mouth modifies only the inertia and energy losses terms because both depend on the flow field at the chosen streamline. These changes must be such that the integral relation is preserved. Therefore, by measuring the inertial term (known as added mass), the term for losses can be measured indirectly. We developed a method to measure the added mass for oscillating flows in tubes with different mouth shapes and compared these measurements with those obtained for a model of the flow through the pump. Our results suggest a way to find a criterion for choosing the geometry of the mouth of the tubes in order to minimize dissipation and improve efficiency of the pump. This work was supported by funds provided by DGAPA-UNAM (Project PAPITT-IN1188608).

  5. Non-Uniformity of the Combustor Exit Flow Temperature in Front of the Gas Turbine

    Directory of Open Access Journals (Sweden)

    Błachnio Józef

    2014-12-01

    Full Text Available Various types of damages to gas-turbine components, in particular to turbine blades, may occur in the course of gas turbine operation. The paper has been intended to discuss different forms of damages to the blades due to non-uniformity of the exit flow temperature. It has been shown that the overheating of blade material and thermal fatigue are the most common reasons for these damages. The paper presents results from numerical experiments with use of the computer model of the aero jet engine designed for simulations. The model has been purposefully modified to take account of the assumed non-homogeneity of the temperature field within the working agent at the turbine intake. It turned out that such non-homogeneity substantially affects dynamic and static properties of the engine considered as an object of control since it leads to a lag of the acceleration time and to increase in fuel consumption. The summarized simulation results demonstrate that the foregoing properties of a jet engine are subject to considerable deterioration in pace with gradual increase of the assumed non-homogeneity of the temperature field. The simulations made it possible to find out that variations of the temperature field nonhomogeneity within the working agent at the turbine intake lead to huge fluctuation of the turbine rpm for the idle run.

  6. PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

    Science.gov (United States)

    Bourquin, Florence; Capitani, Guido; Grütter, Markus Gerhard

    2011-01-01

    Sphingolipids are membrane constituents as well as signaling molecules involved in many essential cellular processes. Serine palmitoyltransferase (SPT) and sphingosine-1-phosphate lyase (SPL), both PLP (pyridoxal 5′-phosphate)-dependent enzymes, function as entry and exit gates of the sphingolipid metabolism. SPT catalyzes the condensation of serine and a fatty acid into 3-keto-dihydrosphingosine, whereas SPL degrades sphingosine-1-phosphate (S1P) into phosphoethanolamine and a long-chain aldehyde. The recently solved X-ray structures of prokaryotic homologs of SPT and SPL combined with functional studies provide insight into the structure–function relationship of the two enzymes. Despite carrying out different reactions, the two enzymes reveal striking similarities in the overall fold, topology, and residues crucial for activity. Unlike their eukaryotic counterparts, bacterial SPT and SPL lack a transmembrane helix, making them targets of choice for biochemical characterization because the use of detergents can be avoided. Both human enzymes are linked to severe diseases or disorders and might therefore serve as targets for the development of therapeutics aiming at the modulation of their activity. This review gives an overview of the sphingolipid metabolism and of the available biochemical studies of prokaryotic SPT and SPL, and discusses the major similarities and differences to the corresponding eukaryotic enzymes. PMID:21710479

  7. Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina.

    Science.gov (United States)

    Miles, Amanda; Tropepe, Vincent

    2016-01-01

    The proper development of the vertebrate retina relies heavily on producing the correct number and type of differentiated retinal cell types. To achieve this, proliferating retinal progenitor cells (RPCs) must exit the cell cycle at an appropriate time and correctly express a subset of differentiation markers that help specify retinal cell fate. Homeobox genes, which encode a family of transcription factors, have been accredited to both these processes, implicated in the transcriptional regulation of important cell cycle components, such as cyclins and cyclin-dependent kinases, and proneural genes. This dual regulation of homeobox genes allows these factors to help co-ordinate the transition from the proliferating RPC to postmitotic, differentiated cell. However, understanding the exact molecular targets of these factors remains a challenging task. This commentary highlights the current knowledge we have about how these factors regulate cell cycle progression and differentiation, with particular emphasis on a recent discovery from our lab demonstrating an antagonistic relationship between Vsx2 and Dmbx1 to control RPC proliferation. Future studies should aim to further understand the direct transcriptional targets of these genes, additional co-factors/interacting proteins and the possible recruitment of epigenetic machinery by these homeobox genes. PMID:27604453

  8. The First Order Correction to the Exit Distribution for Some Random Walks

    Science.gov (United States)

    Kennedy, Tom

    2016-07-01

    We study three different random walk models on several two-dimensional lattices by Monte Carlo simulations. One is the usual nearest neighbor random walk. Another is the nearest neighbor random walk which is not allowed to backtrack. The final model is the smart kinetic walk. For all three of these models the distribution of the point where the walk exits a simply connected domain D in the plane converges weakly to harmonic measure on partial D as the lattice spacing δ → 0. Let ω (0,\\cdot ;D) be harmonic measure for D, and let ω _δ (0,\\cdot ;D) be the discrete harmonic measure for one of the random walk models. Our definition of the random walk models is unusual in that we average over the orientation of the lattice with respect to the domain. We are interested in the limit of (ω _δ (0,\\cdot ;D)- ω (0,\\cdot ;D))/δ . Our Monte Carlo simulations of the three models lead to the conjecture that this limit equals c_{M,L} ρ _D(z) times Lebesgue measure with respect to arc length along the boundary, where the function ρ _D(z) depends on the domain, but not on the model or lattice, and the constant c_{M,L} depends on the model and on the lattice, but not on the domain. So there is a form of universality for this first order correction. We also give an explicit formula for the conjectured density ρ _D.

  9. Pressure suppression pool hydrodynamic studies for horizontal vent exit of Indian PHWR containment

    International Nuclear Information System (INIS)

    The standard Indian PHWR incorporates a pressure suppression type of containment system with a suppression pool.The design of KAPS (Kakrapar Atomic Power Station) suppression pool system adopts a modified system of downcomers having horizontal vents as compared to vertical vents of NAPS (Narora Atomic Power Station). Hydrodynamic studies for vertical vents have been reported earlier. This paper presents hydrodynamic studies for horizontal type vent system during LOCA. These studies include the phenomenon of vent clearing (where the water slug standing in downcomer initially is injected to wetwell due to rapid pressurization of drywell) followed by pool swell (elevation of pool water due to formation of bubbles due to air mass entering pool at the exit of horizontal vents from drywell). The analysis performed for vent clearing and pool swell is based on rigorous thermal hydraulic calculation consisting of conservation of air-steam mixture mass, momentum and thermal energy and mass of air. Horizontal vent of downcomer is modelled in such a way that during steam-air flow, variation of flow area due to oscillating water surface in downcomer could be considered. Calculation predicts that the vent gets cleared in about 1.0 second and the corresponding downward slug velocity in the downcomer is 4.61 m/sec. The maximum pool swell for a conservative lateral expansion is calculated to be 0.56 m. (author). 3 refs., 12 figs

  10. Bionic approach for the prevention of exit-site infections of percutaneous devices.

    Science.gov (United States)

    Großhauser, Johannes; Reiter, Katja; Große-Siestrup, Christian; Kikhney, Judith; Kertzscher, Ulrich; Affeld, Klaus

    2015-06-01

    Exit-site infections remain one of the main complications for percutaneous devices, such as catheters for peritoneal dialysis or drivelines for ventricular assist devices. Many efforts have been made to create a biological seal, yet without long-term success. This study investigates a new kind of percutaneous device which is coated with an extricable polymeric membrane. The bionic approach applies the naturally outwards directed growth of skin structures to technology: by pulling the protective membrane it slowly grows out of the body and a developing sulcus is exposed to dry air and an infection is avoided. In a feasibility study this kind of device was shown to reduce the rate of infection. To further investigate these devices, they were implanted in the skin of goats and observed for a period of more than 500 days. The membranes were pulled with a force of up to 2 N and the resulting movement was recorded. When being pulled, the membranes moved 0.4-0.9 mm per week, showing that the application of a continuously acting, defined force on the protective membrane causes the desired slow movement.

  11. The Self Exitated Induction Generator with Observation Magnetizing Characteristic in The Air Gap

    Directory of Open Access Journals (Sweden)

    Ridwan Gunawan

    2015-02-01

    Full Text Available This paper discusses the Self Exitated induction Generator (SEIG by approaching the induction machine, physically and mathematically which then transformed from three-phase frame abc to-axis frame, direct axis and quadratur-axis. Based on the reactive power demand of induction machine, capacitor mounted on the stator of the induction machine then do the physical and mathematical approach of the system to obtain a state space model. Underknown relationships, magnetization reactance and magnetizing current is not linear, so do mathematical approach to the magnetization reactance equation used in the calculation. Obtained state space model and the magnetic reactance equation is simulated by Runge kutta method of fourth order. The equation of reactance, is simulated by first using the polynomial equation and second using the exponent equation. The load voltage at d axis and q axis using the polynomial laggs 640µs to the exponent equation. The polynomial voltage magnetitude is less than 0.6068 volt from the exponent voltage magnitude

  12. The Relation of Visual Signs In The Narrative Structure of MTV Exit Human Trafficking Campaign Video

    Directory of Open Access Journals (Sweden)

    Winny Gunarti

    2013-08-01

    Full Text Available Human trafficking is a violation of the human rights. One of the campaign to fight against this crime takes the form of a digital campaign that aired on television and internet.   This study discusses the narrative structure of human trafficking campaign video from non-profit organization MTV Exit in 2012. This video campaign combines art collage and graphic art in its narrative structure. Nonverbal visual elements displayed in the form of a digital photo collage with animated illustrations setting. We consider this video campaign quite interesting as it is visually inform the public about the importance of safe migration through the visual signs in the narrative structure. This study analyzes qualitatively the relation of nonverbal visual signs in the narrative collage and illustration. Denotative and connotative analysis with structural semiotics approach is needed to understand the meaning of visual signs in the context of humans as cultural beings in their communities. This study is expected to be a model example of visual communication campaigns that can foster public awareness of the issue of human trafficking, especially for young women and children as young generation.

  13. A Study of the Impulse Wave Discharged from the Exits of Two Parallel Tubes

    Institute of Scientific and Technical Information of China (English)

    Yong-Hun Kweon; Heuy-Dong Kim; Toshiaki Setoguchi; Toshiyuki Aoki

    2003-01-01

    The twin impulse wave leads to very complicated flow fields, such as Mach stem, spherical waves, and vortex ring. The twin impulse wave discharged from the exits of the two tubes placed in parallel is investigated to understand the detailed flow physics associated with the twin impulse wave, compared with those in a single impulse wave. In the current study, the merging phenomena and propagation characteristics of the impulse waves are investigated using a shock tube experiment and by numerical computations. The Harten-Yee's total variation diminishing (TVD) scheme is used to solve the unsteady two-dimensional compressible Euler equations. The Mach number Ms of incident shock wave is changed below 1.5 and the distance between two-parallel tubes, L/d,is changed from 1.2 to 4.0. In the shock tube experiment, the twin impulse waves are visualized by a Schlieren optical system for the purpose of validation of computational work. The results obtained show that on the symmetric axis between two-parallel tubes, the peak pressure produced by the twin impulse waves and its location strongly depend upon the distance between two-parallel tubes, L/d and the incident shock Mach number,Ms. The predicted Schlieren images represent the measured twin-impulse wave with a good accuracy.

  14. The STS-105 crew exits the CTV after Discovery's landing at KSC

    Science.gov (United States)

    2001-01-01

    KENNEDY SPACE CENTER, Fla. Members of the STS-105 crew exit the Crew Transfer Vehicle (CTV) following Discovery's landing on KSC's Shuttle Landing Facility runway 15 and are greeted by NASA Administrator Dan Goldin. From left are Mission Specialists Patrick Forrester and Daniel Barry, Pilot Frederick 'Rick' Sturckow, and Commander Scott 'Doc' Horowitz (shaking hands with Goldin). Looking on are, from left, Kathie Olsen, NASA Chief Scientist; Joe Rothenberg, Associate Administrator, Office of Space Flight; and Courtney Stadd, NASA Headquarters Chief of Staff. Main gear touchdown was at 2:22:58 p.m. EDT; wheel stop, at 2:24:06 p.m. EDT. The 11-day, 21-hour, 12-minute STS-105 mission accomplished the goals set for the 11th flight to the International Space Station: swapout of the resident Station crew; delivery of equipment, supplies and scientific experiments; and installation of the Early Ammonia Servicer and heater cables for the S0 truss on the Station. Discovery traveled 4.3 million miles on its 30th flight into space, the 106th mission of the Space Shuttle program. The landing was the first of five in 2001 to occur in daylight at KSC.

  15. Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm

    Directory of Open Access Journals (Sweden)

    Avinash Waghray

    2015-07-01

    Full Text Available Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs. However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3. Also, Tbx3 facilitates the cell fate transition from pluripotent cells to mesoderm progenitors by directly repressing Wnt pathway members required for differentiation. Wnt signaling regulates differentiation of mESCs into mesoderm progenitors and helps to maintain a naive pluripotent state. We show that Tbx3, a downstream target of Wnt signaling, fine tunes these divergent roles of Wnt signaling in mESCs. In conclusion, we identify a signaling-TF axis that controls the exit of mESCs from a self-renewing pluripotent state toward mesoderm differentiation.

  16. BUILDING 341 Seismic Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Halle, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-06-15

    The Seismic Evaluation of Building 341 located at Lawrence Livermore National Laboratory in Livermore, California has been completed. The subject building consists of a main building, Increment 1, and two smaller additions; Increments 2 and 3.

  17. 私募股权投资基金退出策略比较研究%Comparative Study of Private Equity Investment Fund Exit Strategies

    Institute of Scientific and Technical Information of China (English)

    高松; 霍婷婷

    2014-01-01

    PE capital exit process can be described as to achieve its"Nirvana". The exit quality can largely determine the level of the starting point of the next PE cycle. Based on the substance of private equity funds exit i.e. stock right transfer realization, and according to different transferees, the private equity investment fund exit channels are divided into three categories: external transfer exit, internal transfer exit and public transfer exit. Through game analysis, this paper analyzes the three exit channels from four aspects: companies, investment banks, stock market and equity transferee. Eventually it is concluded that public transfer is the best exit way for private equity funds exit.%PE 槃资本实现退出的过程可谓之其“涅”,退出的好坏能在很大程度上决定下一次PE循环的起点高低。基于私募股权投资基金退出即股权转让变现的实质,按照股权受让方的不同,将私募股权投资基金退出渠道分为三类:外部转让退出、内部转让退出、公开转让退出。本文通过博弈分析对私募股权投资基金三类退出渠道从公司、投资银行、股票交易市场、股权受让方四个角度进行分析,最终得出公开转让是私募股权投资基金最理想的退出方式。

  18. Danish building typologies

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne; Kragh, Jesper

    The objective of TABULA is to develop a harmonised building typology for European countries. Each national building typology will consist of a set of residential model buildings with characteristic energy-related properties (element areas of the thermal building envelope, U-values, supply system...... efficiencies). The model buildings will each represent a specific construction period of the country in question and a specific building size. Furthermore the number of buildings, flats and the overall floor areas will be given, which are represented by the different building types of the national typologies....

  19. Integrating Responsive Building Elements in Buildings

    DEFF Research Database (Denmark)

    Haase, Matthias; Amato, Alex; Heiselberg, Per

    2006-01-01

    energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work and discusses its usefulness for Hong Kong and China. Special focus was put......There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...

  20. Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Guerra-Rebollo, Marta; Mateo, Francesca; Franke, Kristin [Department of Cell Biology, Molecular Biology Institute of Barcelona (IBMB), CSIC, Barcelona Science Park, Helix Building, Baldiri Reixac 15-21, 08028 Barcelona (Spain); Huen, Michael S.Y. [Department of Anatomy, Centre for Cancer Research, The University of Hong Kong, L1, Laboratory Block, 21 Sassoon Road, Hong Kong Special Administrative Region (Hong Kong); Lopitz-Otsoa, Fernando; Rodriguez, Manuel S. [Proteomics Unit, CIC bioGUNE CIBERehd, ProteoRed, Technology Park of Bizkaia, Building 801A, 48160 Derio (Spain); Plans, Vanessa [Department of Cell Biology, Molecular Biology Institute of Barcelona (IBMB), CSIC, Barcelona Science Park, Helix Building, Baldiri Reixac 15-21, 08028 Barcelona (Spain); Thomson, Timothy M., E-mail: titbmc@ibmb.csic.es [Department of Cell Biology, Molecular Biology Institute of Barcelona (IBMB), CSIC, Barcelona Science Park, Helix Building, Baldiri Reixac 15-21, 08028 Barcelona (Spain)

    2012-11-01

    The induction of DNA double-strand breaks (DSBs) elicits a plethora of responses that redirect many cellular functions to the vital task of repairing the injury, collectively known as the DNA damage response (DDR). We have found that, in the absence of DNA damage, the DSB repair factors RNF8 and BRCA1 are associated with the nucleolus. Shortly after exposure of cells to {gamma}-radiation, RNF8 and BRCA1 translocated from the nucleolus to damage foci, a traffic that was reverted several hours after the damage. RNF8 interacted through its FHA domain with the ribosomal protein RPSA, and knockdown of RPSA caused a depletion of nucleolar RNF8 and BRCA1, suggesting that the interaction of RNF8 with RPSA is critical for the nucleolar localization of these DDR factors. Knockdown of RPSA or RNF8 impaired bulk protein translation, as did {gamma}-irradiation, the latter being partially countered by overexpression of exogenous RNF8. Our results suggest that RNF8 and BRCA1 are anchored to the nucleolus through reversible interactions with RPSA and that, in addition to its known functions in DDR, RNF8 may play a role in protein synthesis, possibly linking the nucleolar exit of this factor to the attenuation of protein synthesis in response to DNA damage. -- Highlights: Black-Right-Pointing-Pointer RNF8 and BRCA1 are associated with the nucleolus of undamaged cells. Black-Right-Pointing-Pointer Upon {gamma}-radiation, RNF8 and BRCA1 are translocated from the nucleolus to damage foci. Black-Right-Pointing-Pointer The ribosomal protein RPSA anchors RNF8 to the nucleolus. Black-Right-Pointing-Pointer RNF8 may play previously unsuspected roles in protein synthesis.

  1. Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

    International Nuclear Information System (INIS)

    The induction of DNA double-strand breaks (DSBs) elicits a plethora of responses that redirect many cellular functions to the vital task of repairing the injury, collectively known as the DNA damage response (DDR). We have found that, in the absence of DNA damage, the DSB repair factors RNF8 and BRCA1 are associated with the nucleolus. Shortly after exposure of cells to γ-radiation, RNF8 and BRCA1 translocated from the nucleolus to damage foci, a traffic that was reverted several hours after the damage. RNF8 interacted through its FHA domain with the ribosomal protein RPSA, and knockdown of RPSA caused a depletion of nucleolar RNF8 and BRCA1, suggesting that the interaction of RNF8 with RPSA is critical for the nucleolar localization of these DDR factors. Knockdown of RPSA or RNF8 impaired bulk protein translation, as did γ-irradiation, the latter being partially countered by overexpression of exogenous RNF8. Our results suggest that RNF8 and BRCA1 are anchored to the nucleolus through reversible interactions with RPSA and that, in addition to its known functions in DDR, RNF8 may play a role in protein synthesis, possibly linking the nucleolar exit of this factor to the attenuation of protein synthesis in response to DNA damage. -- Highlights: ► RNF8 and BRCA1 are associated with the nucleolus of undamaged cells. ► Upon γ-radiation, RNF8 and BRCA1 are translocated from the nucleolus to damage foci. ► The ribosomal protein RPSA anchors RNF8 to the nucleolus. ► RNF8 may play previously unsuspected roles in protein synthesis.

  2. CFD Simulations of Supersonic Highly Swirling Flow Exiting a Turbine Vane Row Compared with Experimental Observations

    Science.gov (United States)

    West, Jeff S.; Richardson, Brian R.; Schmauch, Preston; Kenny, Robert J.

    2011-01-01

    Marshall Space Flight Center (MSFC) has been heavily involved in developing the J2-X engine. The Center has been testing a Work Horse Gas Generator (WHGG) to supply gas products to J2-X turbine components at realistic flight-like operating conditions. Three-dimensional time accurate CFD simulations and analytical fluid analysis have been performed to support WHGG tests at MSFC. The general purpose CFD program LOCI/Chem was utilized to simulate flow of products from the WHGG through a turbine manifold, a stationary row of turbine vanes, into a Can and orifice assembly used to control the back pressure at the turbine vane row and finally through an aspirator plate and flame bucket. Simulations showed that supersonic swirling flow downstream of the turbine imparted a much higher pressure on the Can wall than expected for a non-swirling flow. This result was verified by developing an analytical model that predicts wall pressure due to swirling flow. The CFD simulations predicted that the higher downstream pressure would cause the pressure drop across the nozzle row to be approximately half the value of the test objective. With CFD support, a redesign of the Can orifice and aspirator plate was performed. WHGG experimental results and observations compared well with pre-test and post-test CFD simulations. CFD simulations for both quasi-static and transient test conditions correctly predicted the pressure environment downstream of the turbine row and the behavior of the gas generator product plume as it exited the WHGG test article, impacted the flame bucket and interacted with the external environment.

  3. Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Fengli [Boston University School of Medicine, Department of Biophysics (United States); Luecke, Christian [Johann Wolfgang Goethe-Universitaet (Germany); Baier, Leslie J. [NIDDK, NIH, Phoenix Epidemiology and Clinical Research Branch (United States); Sacchettini, James C. [Texas A and M University, Department of Biochemistry and Biophysics (United States); Hamilton, James A. [Boston University School of Medicine, Department of Biophysics (United States)

    1997-04-15

    The human intestinal fatty acid binding protein (I-FABP) is a small (131 amino acids) protein which binds dietary long-chain fatty acids in the cytosol of enterocytes. Recently, an alanine to threonine substitution at position 54 in I-FABP has been identified which affects fatty acid binding and transport, and is associated with the development of insulin resistance in several populations including Mexican-Americans and Pima Indians. To investigate the molecular basis of the binding properties of I-FABP, the 3D solution structure of the more common form of human I-FABP (Ala54) was studied by multidimensional NMR spectroscopy.Recombinant I-FABP was expressed from E. coli in the presence and absence of 15N-enriched media. The sequential assignments for non-delipidated I-FABP were completed by using 2D homonuclear spectra (COSY, TOCSY and NOESY) and 3D heteronuclear spectra(NOESY-HMQC and TOCSY-HMQC). The tertiary structure of human I-FABP was calculated by using the distance geometry program DIANA based on 2519 distance constraints obtained from the NMR data. Subsequent energy minimization was carried out by using the program SYBYL in the presence of distance constraints. The conformation of human I-FABP consists of 10 antiparallel {beta}-strands which form two nearly orthogonal {beta}-sheets of five strands each, and two short {alpha}-helices that connect the {beta}-strands A and B. The interior of the protein consists of a water-filled cavity between the two {beta}-sheets. The NMR solution structure of human I-FABP is similar to the crystal structure of rat I-FABP.The NMR results show significant conformational variability of certain backbone segments around the postulated portal region for the entry and exit of fatty acid ligand.

  4. Welfare Reform and Labor Force Exit by Young, Low-Skilled Single Males.

    Science.gov (United States)

    Groves, Lincoln H

    2016-04-01

    While the labor market woes of low-skilled male workers in the United States over the past several decades have been well documented, the academic literature identifying causal factors leading to declines in labor force participation (LFP) by young, low-skilled males remains scant. To address this gap, I use the timing and characteristics of welfare-reform policies implemented during the 1990s and fixed-effects, instrumental variable regression modeling to show that policies seeking to increase LFP rates for low-skilled single mothers inadvertently led to labor force exit by young, low-skilled single males. Using data from the Current Population Survey and a bundle of work inducements enacted by states throughout the 1990s as exogenous variation in a quasi-experimental design, I find that the roughly 10 percentage point increase in LFP for low-skilled single mothers facilitated by welfare reform resulted in a statistically significant 2.8 percentage point decline in LFP for young, low-skilled single males. After conducting a series of robustness checks, I conclude that this result is driven entirely by white males, who responded to welfare-reform policies with a 3.7 percentage point decline in labor supply. Young black males, as well as other groups of potentially affected workers, appear to be uninfluenced by the labor supply response of less-educated single mothers to welfare reform. Impacts on young, single white males are large and economically significant, suggesting that nearly 150,000 males departed the formal labor market in response to directed welfare-reform policies. PMID:26912351

  5. 29 CFR Appendix to Subpart E of... - Exit Routes, Emergency Action Plans, and Fire Prevention Plans

    Science.gov (United States)

    2010-07-01

    ... adequate number of employees are available at all times during working hours to act as evacuation wardens... with the other employers within the building to assure that conflicts and confusion are avoided during... essential that these employers coordinate their plans with each other to avoid conflicts and confusion....

  6. Impact of the New CLIC Beam Parameters on the Design of the Post-Collision Line and its Exit Window

    CERN Document Server

    Ferrari, A

    2008-01-01

    Following the recent modification of the CLIC beam parameters, we present an updated design of the post-collision line. As a result of the increase of the beamstrahlung photon cone size, the separation of the outgoing beams by the vertical magnetic chicane is more difficult, but still possible. The main changes in the post-collision line design include the implementation of a common dump for the wrong-sign charged particles of the coherent pairs and for the low-energy tails of the disrupted beam, as well as a significant reduction of the overall lattice length (allowing removal of the large refocusing quadrupoles). The thermal and mechanical stresses in the new exit window, 150 m downstream of the interaction point, were computed. We conclude that, despite the recent changes of the CLIC beam parameters and the necessary modifications of the post-collision line and its exit window, their performance is not significantly affected.

  7. Control of Collection Efficiency for Axial Flow Cyclone Dust Collectors with Fixed Guide Vanes and with Funnel Shaped Exit Pipes

    Institute of Scientific and Technical Information of China (English)

    Akira Ogawa; Masaru Arakawa

    2006-01-01

    The experimental result of the collection efficiency of the axial flow cyclone with the fixed guide vanes is lower than that with the tangential inlet pipe to the cyclone body due to the weak angular momentum transfer given by flowing through the guide vanes. However, one of the interesting points is the control of the collection efficiency depended on the funnel shaped exit pipes. The collection efficiencies for these funnel shaped exit pipes are depended on the Froude number. Then, in this paper, the experimental results of the pressure drop and also the collection efficiency using the fly-ash particles and also the comparison of the calculated results of the collection efficiency with the experimental results are described in detail.

  8. Perturbation of the energy loss spectra for an accelerated electron beam due to the photo injector exit

    CERN Document Server

    Salah, W

    2003-01-01

    The influence of the photo-injector exit hall on the energy loss for an accelerated electron beam is investigated, by calculating the total energy transferred from the electrons to the wakefields, which are driven by the beam. The obtained energy loss is compared to those previously obtained for a 'pill-box' cavity. This comparison shows that the influence of this hall, in terms of energy loss, varies over the beam length. It is strongest in the middle of the beam and decreases towards both ends. In consequence of this perturbation, the center of the beam is displaced from its initial position during the first phase (t < 200 ps) where the exit aperture has no effect to a new equilibrium position which takes place at 200 < t < 250 ps. (author)

  9. Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit

    International Nuclear Information System (INIS)

    MELK (maternal embryonic leucine zipper kinase) is a cell cycle dependent protein kinase involved in diverse cell processes including cell proliferation, apoptosis, cell cycle and mRNA processing. Noticeably, MELK expression is increased in cancerous tissues, upon cell transformation and in mitotically-blocked cells. The question of how MELK protein level is controlled is therefore important. Here, we show that MELK protein is restricted to proliferating cells derived from either cancer or normal tissues and that MELK protein level is severely decreased concomitantly with other cell cycle proteins in cells which exit the cell cycle. Moreover, we demonstrate in human HeLa cells and Xenopus embryos that approximately half of MELK protein is degraded upon mitotic exit whereas another half remains stable during interphase. We show that the stability of MELK protein in M-phase is dependent on its phosphorylation state.

  10. Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit

    Energy Technology Data Exchange (ETDEWEB)

    Badouel, Caroline; Chartrain, Isabelle; Blot, Joelle [CNRS UMR 6061 Genetique et Developpement, Universite de Rennes 1, IFR140 GFAS, Faculte de medecine, 2 avenue du Professeur Leon Bernard, CS 34317, 35043 Rennes Cedex (France); Tassan, Jean-Pierre, E-mail: jean-pierre.tassan@univ-rennes1.fr [CNRS UMR 6061 Genetique et Developpement, Universite de Rennes 1, IFR140 GFAS, Faculte de medecine, 2 avenue du Professeur Leon Bernard, CS 34317, 35043 Rennes Cedex (France)

    2010-08-01

    MELK (maternal embryonic leucine zipper kinase) is a cell cycle dependent protein kinase involved in diverse cell processes including cell proliferation, apoptosis, cell cycle and mRNA processing. Noticeably, MELK expression is increased in cancerous tissues, upon cell transformation and in mitotically-blocked cells. The question of how MELK protein level is controlled is therefore important. Here, we show that MELK protein is restricted to proliferating cells derived from either cancer or normal tissues and that MELK protein level is severely decreased concomitantly with other cell cycle proteins in cells which exit the cell cycle. Moreover, we demonstrate in human HeLa cells and Xenopus embryos that approximately half of MELK protein is degraded upon mitotic exit whereas another half remains stable during interphase. We show that the stability of MELK protein in M-phase is dependent on its phosphorylation state.

  11. Canadian medical tourism companies that have exited the marketplace: Content analysis of websites used to market transnational medical travel

    OpenAIRE

    Turner Leigh

    2011-01-01

    Abstract Background Medical tourism companies play an important role in promoting transnational medical travel for elective, out-of-pocket medical procedures. Though researchers are paying increasing attention to the global phenomenon of medical tourism, to date websites of medical tourism companies have received limited scrutiny. This article analyzes websites of Canadian medical tourism companies that advertised international healthcare but ultimately exited the marketplace. Using content a...

  12. The Influence of Psychographic Variables on the Theory of Exit, Voice, and Loyalty of Customer Complaints Behaviour in Banks

    Directory of Open Access Journals (Sweden)

    Preko Alexander

    2015-12-01

    Full Text Available This paper analyses Customer Complaints Behaviour (CCB using psychographic factors and the Theory of Exit, Voice and Loyalty. Prior studies on the continent of Africa have explored customer dissatisfaction, service failure, complaints handling and complaint attitudes, but not in association with psychographic factors. This research gap is addressed with a new conceptual understanding that integrates psychographic variables and the Theory of Exit, Voice and Loyalty in a single study. In total, 171 valid questionnaires were gathered from customers of two public banks in Accra chosen randomly, and a convenience sampling method was used for the respondents. This study has revealed that assertiveness, conservatism, attitude towards complaints, sense of justice, service attribute significantly influence the theory of Exit, Voice and Loyalty of CCB. What is more, the findings have also shown that there is a statistical difference between complainers and non-complainers. Complainers are more likely to stay loyal, and are less likely to voice out or leave their bankers. We suggest that banks should not only center CCB strategies towards complainers, but should also take into account non-complainers as they are equally important to businesses.

  13. The influence of different types of satellite exiting in system RAIM performance in BeiDou Satellite Navigation System

    Science.gov (United States)

    Wang, Shi-tai; Peng, Jun-huan

    2015-12-01

    The space constellation of BeiDou Navigation Satellite System(BDS)has three main components, Geostationary Earth Orbits (GEOs), Medium Earth Orbits (MEOs) and Inclined Geosynchronous Satellite Orbits(IGSOs).This paper selected 6 satellite respectively in three types to simulate their exiting service, and used the statistical methods to assess receiver autonomous integrity monitoring RAIM availability and fault detection FD capability of BeiDou14 Phase with 14 satellites under the circumstances. This paper assessed RAIM availability performance from satellites and constellation geometry configuration by the number of visible satellites (NVS, NVS>~5) and position dilution of precision (PDOP, PDOPMDE). The analyses of simulation results testify that the exiting of single MEO or IGSO satellite have no obvious effect on RAIM availability and error detection ability. However GEO satellite's exiting can make the number of points in where the constellation geometry is not available and maximum minimum detectable deviation and maximum minimum detectable influence significantly increase. Relative to other two satellites, GEO satellites' health have a significant impact on the RAIM performance of BDS.

  14. The Building Commissioning Handbook.

    Science.gov (United States)

    Heinz, John A.; Casault, Rick

    This book discusses building commissioning, which is the process of certifying that a new facility meets the required specifications. As buildings have become more complex, the traditional methods for building start-up and final acceptance have been proven inadequate, and building commissioning has been developed, which often necessitates the use…

  15. Global building physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2013-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or ‘global’, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. This brief article reports the keynote...

  16. Global Building Physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2012-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or “global”, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. The keynote lecture and this brief paper...

  17. Retrofitting Listed Buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2011-01-01

    The paper presents a case study where the energy demand for a listed building constructed in 1900 is reduced. Many older buildings are listed and have restrictions that include the entire building or that include only its exterior. For the building presented, only its exterior facade is listed...... of the local urban environment and therefore listed. The reduced energy demand, related to individual measures, is estimated and building physics requirements are addressed together with the economic options for evaluating the profitability....

  18. ICT Enhanced Buildings Potentials

    DEFF Research Database (Denmark)

    Christiansson, Per

    2007-01-01

    The paper describes and gives example on how Information and Communication, ICT, can and will enhance and support the building functional systems defined from client and end-user needs and requirements. The building systems may be derived from functional requirements on buildings such as usability...... and security on highest level with sub-systems definitions on lever levels. Building functional sub-systems may be defined for user comfort, indoor-climate, evacuation, space configuration, aesthetics, O&M etc. These building systems are supported by Information and Communication Technology, ICT, and building...... with focus on virtual building models support, new services and user environment definitions and development, virtual spaces and augmented reality, intelligent building components, application ontologies, and ICT systems integration to illustrate ICT enhanced buildings potentials and R&D needs.  ...

  19. Sustainable Buildings in Interaction

    DEFF Research Database (Denmark)

    Elle, Morten

    2007-01-01

    The first attempts to build sustainable buildings in Denmark were typically located on the countryside. The basic idea was to create buildings that were independent of the technical infrastructure. District heating has, however, been the dominating solution to heating in buildings in Denmark......, and the focus on sustainable building have gradually turned from special houses on the countryside to normally looking houses in the urban fabric, integrated in the technical infrastructure. Some new built urban areas in Denmark will, however, not have to be supplied with district heating – these developments...... are going to consist of passive houses. The first sustainable buildings were built by their users, and the user – building interaction still play a decisive role for the performance of the present sustainable buildings. The users have to understand how the building functions. Urban design is essential...

  20. An indoor augmented reality mobile application for simulation of building evacuation

    Science.gov (United States)

    Sharma, Sharad; Jerripothula, Shanmukha

    2015-03-01

    Augmented Reality enables people to remain connected with the physical environment they are in, and invites them to look at the world from new and alternative perspectives. There has been an increasing interest in emergency evacuation applications for mobile devices. Nearly all the smart phones these days are Wi-Fi and GPS enabled. In this paper, we propose a novel emergency evacuation system that will help people to safely evacuate a building in case of an emergency situation. It will further enhance knowledge and understanding of where the exits are in the building and safety evacuation procedures. We have applied mobile augmented reality (mobile AR) to create an application with Unity 3D gaming engine. We show how the mobile AR application is able to display a 3D model of the building and animation of people evacuation using markers and web camera. The system gives a visual representation of a building in 3D space, allowing people to see where exits are in the building through the use of a smart phone or tablets. Pilot studies were conducted with the system showing its partial success and demonstrated the effectiveness of the application in emergency evacuation. Our computer vision methods give good results when the markers are closer to the camera, but accuracy decreases when the markers are far away from the camera.

  1. Applied building physics

    CERN Document Server

    Hens, Hugo S L C

    2012-01-01

    The energy crises of the 1970s, persisting moisture problems, complaints about sick buildings, thermal, visual and olfactory discomfort, and the move towards more sustainability in building construction have pushed Building Physics to the forefront of building innovation. The societal pressure to diminish energy consumption in buildings without impairing usability acted as a trigger to activate the whole notion of performance based design and construction. As with all engineering sciences, Building Physics is oriented towards application, which is why, after a first book on fundamentals this s

  2. Symptoms of angina pectoris increase the probability of disability pension and premature exit from the workforce even in the absence of obstructive coronary artery disease

    DEFF Research Database (Denmark)

    Jespersen, Lasse; Abildstrøm, Steen Z; Hvelplund, Anders;

    2013-01-01

    To evaluate probabilities of disability pension (DP) and premature exit from the workforce (PEW) in patients with stable angina symptoms and no obstructive coronary artery disease (CAD) at angiography compared with obstructive CAD and asymptomatic reference individuals.......To evaluate probabilities of disability pension (DP) and premature exit from the workforce (PEW) in patients with stable angina symptoms and no obstructive coronary artery disease (CAD) at angiography compared with obstructive CAD and asymptomatic reference individuals....

  3. Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

    OpenAIRE

    Mochida, Satoru; Ikeo, Satoshi; Gannon, Julian; Hunt, Tim

    2009-01-01

    Entry into mitosis depends on the activity of cyclin-dependent kinases (CDKs). Conversely, exit from mitosis occurs when mitotic cyclins are degraded, thereby extinguishing CDK activity. Exit from mitosis must also require mitotic phosphoproteins to revert to their interphase hypophosphorylated forms, but there is a controversy about which phosphatase(s) is/are responsible for dephosphorylating the CDK substrates. We find that PP2A associated with a B55δ subunit is relatively specific for a m...

  4. The influence of the stagnation zone on the fluid dynamics at the nozzle exit of a confined and submerged impinging jet

    Science.gov (United States)

    Jeffers, Nicholas; Stafford, Jason; Conway, Ciaran; Punch, Jeff; Walsh, Edmond

    2016-02-01

    Low profile impinging jets provide a means to achieve high heat transfer coefficients while occupying a small quantity of space. Consequently, they are found in many engineering applications such as electronics cooling, annealing of metals, food processing, and others. This paper investigates the influence of the stagnation zone fluid dynamics on the nozzle exit flow condition of a low profile, submerged, and confined impinging water jet. The jet was geometrically constrained to a round, 16-mm diameter, square-edged nozzle at a jet exit to target surface spacing ( H/ D) that varied between 0.25 flow regimes is the main focus of this paper; however, laminar flow data are also presented between 1350 measurement facility was designed and commissioned to utilise particle image velocimetry in order to quantitatively measure the fluid dynamics both before and after the jet exits its nozzle. The velocity profiles are normalised with the mean velocity across the nozzle exit, and turbulence statistics are also presented. The primary objective of this paper is to present accurate flow profiles across the nozzle exit of an impinging jet confined to a low H/ D, with a view to guide the boundary conditions chosen for numerical simulations confined to similar constraints. The results revealed in this paper suggest that the fluid dynamics in the stagnation zone strongly influences the nozzle exit velocity profile at confinement heights between 0 0.5—where D is the inner diameter of the jet—in order to minimise modelling uncertainty.

  5. Comfort control in buildings

    CERN Document Server

    Castilla, Maria del Mar; Rodriguez, Francisco de Asis

    2014-01-01

    This book describes both concepts and development of advanced comfort control systems in buildings, with significant energy saving, and attention to thermal, visual and indoor air quality. The concepts are proven through real tests in a bioclimatic building.

  6. Building the Korogwe Laboratory

    DEFF Research Database (Denmark)

    Knudsen, Jakob; von Seidlein, Lorenz; Richard, Jean Pierre

    2011-01-01

    An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania.......An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania....

  7. Building Design & Construction - Sustainability

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-11-01

    Offers a brief history of green building; presents the results of a specially commissioned survey; and analyzes the chief trends, issues, and published research, based on interviews with dozens of experts and participants in green building.

  8. Robotic buildings(s)

    NARCIS (Netherlands)

    Bier, H.H.

    2014-01-01

    Technological and conceptual advances in fields such as artificial intelligence, robotics, and material science have enabled robotic building to be in the last decade prototypically implemented. In this context, robotic building implies both physically built robotic environments and robotically supp

  9. Better Buildings Challenge Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-06-01

    The Better Buildings Challenge is a national leadership initiative calling on corporate chief executive officers, university presidents, and state and local leaders to make a significant commitment to building energy efficiency.

  10. Requirements for existing buildings

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne

    2012-01-01

    This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....

  11. Integrated Building Health Management

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract: Building health management is an important part in running an efficient and cost-effective building. Many problems in a building’s system can go...

  12. Allegheny County Building Footprints

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains photogrammetrically compiled roof outlines of buildings. All near orthogonal corners are square. Buildings that are less than 400 square feet...

  13. Buildings interoperability landscape - Draft

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave B. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2015-02-01

    Buildings are an integral part of our nation’s energy economy. The advancement in information and communications technology (ICT) has revolutionized energy management in industrial facilities and large commercial buildings. As ICT costs decrease and capabilities increase, buildings automation and energy management features are transforming the small-medium commercial and residential buildings sectors. A vision of a connected world in which equipment and systems within buildings coordinate with each other to efficiently meet their owners’ and occupants’ needs, and where buildings regularly transact business with other buildings and service providers (such as gas and electric service providers) is emerging. However, while the technology to support this collaboration has been demonstrated at various degrees of maturity, the integration frameworks and ecosystems of products that support the ability to easily install, maintain, and evolve building systems and their equipment components are struggling to nurture the fledging business propositions of their proponents.

  14. Building Materials Property Table

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-04-16

    This information sheet describes a table of some of the key technical properties of many of the most common building materials taken from ASHRAE Fundamentals - 2001, Moisture Control in Buildings, CMHC, NRC/IRC, IEA Annex 24, and manufacturer data.

  15. Exit of a blast wave from a conical nozzle. [flow field calculations by Eulerian computer code DORF

    Science.gov (United States)

    Kim, K.; Johnson, W. E.

    1976-01-01

    The Eulerian computer code DORF was used in the analysis of a two-dimensional, unsteady flow field resulting from semi-confined explosions for propulsive applications. Initially, the ambient gas inside the conical shaped nozzle is set into motion due to the expansion of the explosion product gas, forming a shock wave. When this shock front exits the nozzle, it takes almost a spherical form while a complex interaction between the nozzle and compression and rarefaction waves takes place behind the shock. The results show an excellent agreement with experimental data.

  16. Effects of Generational Competition and Substitution on Late Labour Participation and Labour Market Exit from a Multilevel Perspective*

    Directory of Open Access Journals (Sweden)

    Dr. Henriette Engelhardt

    2013-12-01

    Full Text Available In this paper, we investigate the effects of demographic, economic and labour market structures on labour market participation and on the transition to inactivity (exit for older males in eleven European countries. Theoretically, our analysis is guided by considerations of intragenerational competition and intergenerational substitution. Following Easterlin’s hypothesis that intragenerational competition rises with cohort size, we assume a negative effect of cohort size on labour market participation and a positive effect on early exit from the labour market. Taking into account that different cohorts are substitutes at least to a certain extent, we assume that the probability of an early exit will be reduced by a high intergenerational exchange ratio in favour of older workers. Thus, labour market participation is infl uenced by the populations’ age structure both when entering the labour force and during the career. Moreover, low shares of graduates in older cohorts are expected to reduce older workers’ chances of labour market participation. In addition to demographic structures, general economic conditions, such as per capita GDP and its development over time, act both to further and to hamper the employment of older workers. Additionally, labour market structures, such as unemployment rates, the extent of part-time work or the amount of service jobs infl uence individual participation and the transition to inactivity. To test these hypotheses, we use merged data from the fi rst two waves of SHARE and macro-level indicators from Eurostat. We estimate a two-level random-intercept logit model which allows us to determine the share of variance in international late careers that can be attributed to countryspecifi c factors and can quantify the relative impact of specifi c socio-demographic and socio-economic backgrounds. Our results imply that cross-national variance in labour market participation is mainly driven by the instance of long

  17. One-Dimensional Simulation of the Pressure Wave near the Exit of a High-Speed Train Tunnel

    Institute of Scientific and Technical Information of China (English)

    杨宇光; 朱克勤; 席葆树

    2001-01-01

    The one-dimensional (1-D) unsteady flow induced by a high-speed train entering a tunnel isnumerically studied by the method of characteristics. The tube area is dependent on time and distance. Theenergy equation used by Kage et al. is corrected to avoid the conflict with the isentropic assumption. Theeffect of the tunnel hood on the pressure wave is studied near the tunnel exit. Results show that the tunnel hoodis useful in reducing the peak value and the time derivative of the pressure wave.``

  18. Assisting victims of human trafficking: strategies to facilitate identification, exit from trafficking, and the restoration of wellness.

    Science.gov (United States)

    Hodge, David R

    2014-04-01

    Human trafficking is a pressing social justice concern. Social work is uniquely situated to address this problem. However, despite the profession's commitment to social justice, the scholarship to equip social workers to address this issue has been largely absent from professional discourse. To address this gap, this article helps social work practitioners to assist victims of human trafficking. After orienting readers to the scope and process of human trafficking, the topics of victim identification, exit from trafficking, and the restoration of psychological wellness are discussed. By equipping themselves in these three areas, practitioners can advance social justice on behalf of some of the most exploited people in the world.

  19. Building the ISS

    Institute of Scientific and Technical Information of China (English)

    石继忠; 李秀霞

    2007-01-01

    Have you seen people building houses?To build a house,you need workers.They use their hands,tools and machines to put everything together. Building the ISS is almost the same.The difference is that the workers are astronauts.They

  20. Future Green Buildings

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Drysdale, David; Lund, Henrik;

    Efficient buildings are essential for an affordable Danish energy supply in 2050. The purpose of this report is to describe the contribution and role of the building sector in a 100% renewable energy future, as well as the transitions that are necessary in the building sector to support this chan...

  1. Marine Building Technology

    OpenAIRE

    Westby, Ola

    2006-01-01

    This textbook is all about building of ships, platforms and other offshore installations. The geometry and functions of systems and structures are explained as an introduction to management and technology at shipyards and building sites. Both loadbearing structures, outfitting and installation of accommodation are included. Project management, production planning, cost calculations, building methods, discipline knowledge (welding, painting, insulation, mechanical, piping etc.), fabrication te...

  2. Building with History

    DEFF Research Database (Denmark)

    Douglas-Jones, Rachel; Adams, Charlotte; Green, Adrian;

    2014-01-01

    on the thermal and energetic properties of historic buildings, as distinct from their social meaning and use. A similar separation between the physi- cal building and its social use is inherent in methodologies such as energy audits that constitute key devices through which buildings are institution- ally...

  3. Research on the Safe Evacuation near the Building Exit%建筑物出口的人员疏散研究

    Institute of Scientific and Technical Information of China (English)

    赵士达; 张楠; 赵颖

    2015-01-01

    根据建筑物出口疏散的特点,提出了一种改进型的元胞自动机模型.研究了影响人员疏散速度的两个因素:人员之间的相互拥挤产生的冲突和人员移动到出口时由于转弯导致的移动速度减慢.使用数学方法推导得出了摩擦冲突函数和转弯函数.通过计算机仿真与实际疏散实验对比发现,在不考虑转弯因素的情况下,仿真结果与实验结果偏差较大,而在同时考虑相互冲突和转弯因素时的仿真结果与实验结果偏差很小,验证了这两个因素是疏散仿真不可忽略的因素.通过分析仿真结果,验证了本文所采用的模型和函数能够准确地反映实际疏散过程,具有较高的实用价值.

  4. Greek Exit from the Crisis—A Pressing and Much-Needed Public Service Reform

    Directory of Open Access Journals (Sweden)

    Demetrios Argyriades

    2013-04-01

    Full Text Available Greece is in a deep crisis; the worst in all of Europe and the worst experienced in 45 years. Greece is no stranger to crises, but most have been exogenous: the Second World War and the Cold War, for instance. Sadly, unlike these crises, the present one is home-made. The wounds that it has caused are largely self-inflicted. It is especially difficult to fathom the logic of strikes by public service unions—repeated, relentless and militant. They paralyzed the country, drove investors and tourists away and added to the burdens that the economy and the people have had to bear. These strikes, and some public servants’ attitudes in the face of the crisis itself, brought into sharp relief the serious capacity deficit in the Greek administrative system, which has been at the root of the problem the country is currently facing. This statement begs the question: how can that be? What, after 30 years of public service reform, presumed to modernize and help the country approximate the standards embedded in the Common European Administrative Space? The paper will suggest that the reforms of the 1980s were only superficially reforms to improve the effectiveness and quality of the Service. Like parallel changes in higher education, the principal objective was harnessing officialdom, and as many voters as possible, to the chariot of PASOK—the political party established by Andreas Papandreou—which effectively governed the country for most of the period in question. The lesson from this experience may be none other, in fact, than clear convincing proof that partisan concerns and institution-building seldom make a good combination. For Greece, in light of the crisis, effective integration in the EU remains a daunting challenge. It calls for bold reforms, but these must be undertaken with institution-building, the country’s general interest, and long term needs in mind.

  5. Building Order in the Building Company Organization

    OpenAIRE

    Krivdová, Magdaléna

    2013-01-01

    The aim of the thesis is to describe an organization of a building order, and to show its key phases. The individual phases of how a order is completed in a company are shown on practical examples. The first two chapters deal with the current situation of today's construction industry; consequently, the reasons for introducing the principles of project management into the construction business practice are mentioned. The third chapter is devoted to the description of a building order. It...

  6. Controlling the intelligent building

    Energy Technology Data Exchange (ETDEWEB)

    LeBlanc, R.J.

    1985-08-01

    Companies will be able to locate in intelligent buildings that offer access to a variety of sophisticated communications equipment, at the heart of which are building controls that ensure a comfortable and safe working environment for the occupants. Future buildings will include advanced telephones or workstations with built-in building control sensors for temperature, light level, and security. Advanced telecommunication systems may have telephone cabinets with built-in control functions which eliminate the need for discrete control systems. The owners and tenants will both enjoy benefits if the controls are carefully selected and designed so that they integrate into a single building package.

  7. Net zero energy buildings

    Energy Technology Data Exchange (ETDEWEB)

    Nieminen, J., Email: jyri.nieminen@vtt.fi

    2012-06-15

    Two net zero apartment buildings with basically similar architecture have been built in Finland, in Kuopio (latitude 62.90) and in Jaervenpaeae (latitude 60.50). The aim was to test the possibilities to build zero energy buildings at high latitudes. The Kuopio case is a student hostel and the Jaervenpaeae case a home for elderly people. The total energy demand in the buildings are 102 MWh for Kuopio and 94.3 for Jaervenpaeae corresponding to 48 and 45 and kWh/gross-m2. The buildings utilise district heat and are connected to the local grid. The renewable energy production bases in the Kuopio case on solar heat and photovoltaics. The Kuopio building has been finished in 2010 and the Jaervenpaeae building in 2011. (orig.)

  8. Commercial Buildings Characteristics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-29

    Commercial Buildings Characteristics 1992 presents statistics about the number, type, and size of commercial buildings in the United States as well as their energy-related characteristics. These data are collected in the Commercial Buildings Energy Consumption Survey (CBECS), a national survey of buildings in the commercial sector. The 1992 CBECS is the fifth in a series conducted since 1979 by the Energy Information Administration. Approximately 6,600 commercial buildings were surveyed, representing the characteristics and energy consumption of 4.8 million commercial buildings and 67.9 billion square feet of commercial floorspace nationwide. Overall, the amount of commercial floorspace in the United States increased an average of 2.4 percent annually between 1989 and 1992, while the number of commercial buildings increased an average of 2.0 percent annually.

  9. Numerical study on the electron-wall interaction in a Hall thruster with segmented electrodes placed at the channel exit

    Institute of Scientific and Technical Information of China (English)

    Qing Shao-Wei; E Peng; Duan Ping; Xu Dian-Guo

    2013-01-01

    Electron-wall interaction is always recognized as an important physical problem because of its remarkable influences on thruster discharge and performance.Based on existing theories,an electrode is predicted to weaken electron-wall interaction due to its low secondary electron emission characteristic.In this paper,the electron-wall interaction in an Aton-type Hall thruster with low-emissive electrodes placed near the exit of discharge channel is studied by a fully kinetic particle-incell method.The results show that the electron-wall interaction in the region of segmented electrode is indeed weakened,but it is significantly enhanced in the remaining region of discharge channel.It is mainly caused by electrode conductive property which makes equipotential lines convex toward channel exit and even parallel to wall surface in near-wall region; this convex equipotential configuration results in significant physical effects such as repelling electrons,which causes the electrons to move toward the channel center,and the electrons emitted from electrodes to be remarkably accelerated,thereby increasing electron temperature in the discharge channel,etc.Furthermore,the results also indicate that the discharge current in the segmented electrode case is larger than in the non-segmented electrode case,which is qualitatively in accordance with previous experimental results.

  10. A simple analytical method to estimate all exit parameters of a cross-flow air dehumidifier using liquid desiccant

    Science.gov (United States)

    Bassuoni, M.M.

    2013-01-01

    The dehumidifier is a key component in liquid desiccant air-conditioning systems. Analytical solutions have more advantages than numerical solutions in studying the dehumidifier performance parameters. This paper presents the performance results of exit parameters from an analytical model of an adiabatic cross-flow liquid desiccant air dehumidifier. Calcium chloride is used as desiccant material in this investigation. A program performing the analytical solution is developed using the engineering equation solver software. Good accuracy has been found between analytical solution and reliable experimental results with a maximum deviation of +6.63% and −5.65% in the moisture removal rate. The method developed here can be used in the quick prediction of the dehumidifier performance. The exit parameters from the dehumidifier are evaluated under the effects of variables such as air temperature and humidity, desiccant temperature and concentration, and air to desiccant flow rates. The results show that hot humid air and desiccant concentration have the greatest impact on the performance of the dehumidifier. The moisture removal rate is decreased with increasing both air inlet temperature and desiccant temperature while increases with increasing air to solution mass ratio, inlet desiccant concentration, and inlet air humidity ratio. PMID:25685485

  11. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.

    Science.gov (United States)

    Raychaudhuri, Sumana; Espenshade, Peter J

    2015-06-01

    Layers of quality control ensure proper protein folding and complex formation prior to exit from the endoplasmic reticulum. The fission yeast Dsc E3 ligase is a Golgi-localized complex required for sterol regulatory element-binding protein (SREBP) transcription factor activation that shows architectural similarity to endoplasmic reticulum-associated degradation E3 ligases. The Dsc E3 ligase consists of five integral membrane proteins (Dsc1-Dsc5) and functionally interacts with the conserved AAA-ATPase Cdc48. Utilizing an in vitro ubiquitination assay, we demonstrated that Dsc1 has ubiquitin E3 ligase activity that requires the E2 ubiquitin-conjugating enzyme Ubc4. Mutations that specifically block Dsc1-Ubc4 interaction prevent SREBP cleavage, indicating that SREBP activation requires Dsc E3 ligase activity. Surprisingly, Golgi localization of the Dsc E3 ligase complex also requires Dsc1 E3 ligase activity. Analysis of Dsc E3 ligase complex formation, glycosylation, and localization indicated that Dsc1 E3 ligase activity is specifically required for endoplasmic reticulum exit of the complex. These results define enzyme activity-dependent sorting as an autoregulatory mechanism for protein trafficking.

  12. Nuclear energy - no thanks. The long way to the exit; Atomkraft - nein danke. Der lange Weg zum Ausstieg

    Energy Technology Data Exchange (ETDEWEB)

    Sternstein, Wolfgang

    2013-07-01

    The anti-nuclear movement is one of the most successful social movements of the recent history of Germany and firmly anchored in huge parts of the population. After a struggle lasting more than forty years it has nearly reached its aims: The exit from nuclear energy and a rethinking in direction of alternative energy concepts. Decisive for the nuclear exit of the Federal government were thereby less the nuclear accidents of Harrisburg (1979), Chernobyl (1986), and Fukushima (2011) but rather the decades-long, stubborn commitment of numerous citizens as well as of citizen's initiatives. ''Nuclear energy - no thanks.'' is the analysis of the citizen's movement from Wyhl until Gorleben. The nonviolent activist and peace researcher Sternstein was there from the beginning and reports about anger and indignation that has been condensed to the social movement with political objectives. Extremely helpful are thereby the methods and strategies of nonviolent actions described by him.

  13. A simple analytical method to estimate all exit parameters of a cross-flow air dehumidifier using liquid desiccant.

    Science.gov (United States)

    Bassuoni, M M

    2014-03-01

    The dehumidifier is a key component in liquid desiccant air-conditioning systems. Analytical solutions have more advantages than numerical solutions in studying the dehumidifier performance parameters. This paper presents the performance results of exit parameters from an analytical model of an adiabatic cross-flow liquid desiccant air dehumidifier. Calcium chloride is used as desiccant material in this investigation. A program performing the analytical solution is developed using the engineering equation solver software. Good accuracy has been found between analytical solution and reliable experimental results with a maximum deviation of +6.63% and -5.65% in the moisture removal rate. The method developed here can be used in the quick prediction of the dehumidifier performance. The exit parameters from the dehumidifier are evaluated under the effects of variables such as air temperature and humidity, desiccant temperature and concentration, and air to desiccant flow rates. The results show that hot humid air and desiccant concentration have the greatest impact on the performance of the dehumidifier. The moisture removal rate is decreased with increasing both air inlet temperature and desiccant temperature while increases with increasing air to solution mass ratio, inlet desiccant concentration, and inlet air humidity ratio.

  14. Random Bit Flipping and EXIT Charts for Nonuniform Binary Sources and Joint Source-Channel Turbo Systems

    Directory of Open Access Journals (Sweden)

    Luc Vandendorpe

    2009-01-01

    Full Text Available Joint source-channel turbo techniques have recently been explored a lot in literature as one promising possibility to lower the end-to-end distortion, with fixed length codes, variable length codes, and (quasi arithmetic codes. Still, many issues remain to be clarified before production use. This short contribution clarifies very concisely several issues that arise with EXIT charts and nonuniform binary sources (a nonuniform binary source can be the result of a nonbinary source followed by a binary source code. We propose two histogram-based methods to estimate the charts and discuss their equivalence. The first one is a mathematical generalization of the original EXIT charts to nonuniform bits. The second one uses a random bit flipping to make the bits virtually uniform and has two interesting advantages: (1 it handles straightforwardly outer codes with an entropy varying with the bit position, and (2 it provides a chart for the inner code that is independent of the outer code.

  15. THE NITROGEN OXIDE CONCENTRATION DEPENDENCE ON HEAT LOSSES WITH EXIT SMOKE GASES OF HEAT-GENERATING PLANTS

    Directory of Open Access Journals (Sweden)

    A. A. Sedaev

    2012-04-01

    Full Text Available Problem statement. The most significant heat losses are losses associated with exit gases. It is these losses that determine the scale of heat emissions into the plant air with fuel combustion products and reduce the environmental safety of the plant. Many of the derived methods for reducing the nitrogen oxide emission associated with gas purification systems provide a high degree of smoke gas purification, but these methods are based on the use of various chemicals, which sharply reduces their environmental and operational characteristics.Results. The suggested method of simultaneous purification and recycling of gaseous emissions of heat-generating plants differs profitably from the existing ones. Its application will improve tech-nical and economic and also environmental characteristics of heat-generating plants and will make the characteristics of the energy enterprise a closer match to those of waste-free, environmentally-friendly and profitable enterprises.Conclusions. The obtained results confirm the fact that reduction of heat losses with exit gases re-sults in a reduction of nitrogen oxide emissions. Therefore, an increase in environmental safety of a boiler unit can be achieved in tandem with one in heat efficiency.

  16. Driving simulator evaluation of drivers' response to intersections with dynamic use of exit-lanes for left-turn.

    Science.gov (United States)

    Zhao, Jing; Yun, Meiping; Zhang, H Michael; Yang, Xiaoguang

    2015-08-01

    With the worsening of urban traffic congestion in large cities around the world, researchers have been looking for unconventional designs and/or controls to squeeze more capacity out of intersections, the most common bottlenecks of the road network. One of these innovative intersection designs, known as the exit-lanes for left-turn (EFL), opens up exit-lanes to be used by left-turn traffic with the help of an additional traffic light installed at the median opening (the pre-signal). This paper studies how drivers respond to EFL intersections with a series of driving simulator experiments. In our experiments, 64 drivers were recruited and divided into two groups. One group is trained to use the EFL while the other group is not. In addition, four scenarios were considered with different sign and marking designs and traffic conditions in the experiments. Results indicate that drivers show certain amount of confusion and hesitation when encountering an EFL intersection for the first time. They can be overcome, however, by increasing exposure through driver education or by cue provided from other vehicles. Moreover, drivers unfamiliar with EFL operation can make a left turn using the conventional left-turn lanes as usual. The EFL operation is not likely to pose any serious safety risk of the intersection in real life operations. PMID:25969158

  17. Metadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLT.

    Directory of Open Access Journals (Sweden)

    Ina Bisha

    2014-12-01

    Full Text Available Sodium-Galactose Transporter (SGLT is a secondary active symporter which accumulates sugars into cells by using the electrochemical gradient of Na+ across the membrane. Previous computational studies provided insights into the release process of the two ligands (galactose and sodium ion into the cytoplasm from the inward-facing conformation of Vibrio parahaemolyticus sodium/galactose transporter (vSGLT. Several aspects of the transport mechanism of this symporter remain to be clarified: (i a detailed kinetic and thermodynamic characterization of the exit path of the two ligands is still lacking; (ii contradictory conclusions have been drawn concerning the gating role of Y263; (iii the role of Na+ in modulating the release path of galactose is not clear. In this work, we use bias-exchange metadynamics simulations to characterize the free energy profile of the galactose and Na+ release processes toward the intracellular side. Surprisingly, we find that the exit of Na+ and galactose is non-concerted as the cooperativity between the two ligands is associated to a transition that is not rate limiting. The dissociation barriers are of the order of 11-12 kcal/mol for both the ion and the substrate, in line with kinetic information concerning this type of transporters. On the basis of these results we propose a branched six-state alternating access mechanism, which may be shared also by other members of the LeuT-fold transporters.

  18. CDK inhibitors, p21{sup Cip1} and p27{sup Kip1}, participate in cell cycle exit of mammalian cardiomyocytes

    Energy Technology Data Exchange (ETDEWEB)

    Tane, Shoji; Ikenishi, Aiko; Okayama, Hitomi; Iwamoto, Noriko [School of Life Sciences, Faculty of Medicine, Tottori University, Yonago 683-8503 (Japan); Nakayama, Keiichi I. [Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582 (Japan); Takeuchi, Takashi, E-mail: takeuchi@med.tottori-u.ac.jp [School of Life Sciences, Faculty of Medicine, Tottori University, Yonago 683-8503 (Japan)

    2014-01-17

    Highlights: •Expression of p21 and p27 in the hearts showed a peak during postnatal stages. •p21 and p27 bound to cyclin E, cyclin A and CDK2 in the hearts at postnatal stages. •Cardiomyocytes in both KO mice showed failure in the cell cycle exit at G1-phase. •These data show the first apparent phenotypes in the hearts of Cip/Kip KO mice. -- Abstract: Mammalian cardiomyocytes actively proliferate during embryonic stages, following which cardiomyocytes exit their cell cycle after birth. The irreversible cell cycle exit inhibits cardiac regeneration by the proliferation of pre-existing cardiomyocytes. Exactly how the cell cycle exit occurs remains largely unknown. Previously, we showed that cyclin E- and cyclin A-CDK activities are inhibited before the CDKs levels decrease in postnatal stages. This result suggests that factors such as CDK inhibitors (CKIs) inhibit CDK activities, and contribute to the cell cycle exit. In the present study, we focused on a Cip/Kip family, which can inhibit cyclin E- and cyclin A-CDK activities. Expression of p21{sup Cip1} and p27{sup Kip1} but not p57{sup Kip2} showed a peak around postnatal day 5, when cyclin E- and cyclin A-CDK activities start to decrease. p21{sup Cip1} and p27{sup Kip1} bound to cyclin E, cyclin A and CDK2 at postnatal stages. Cell cycle distribution patterns of postnatal cardiomyocytes in p21{sup Cip1} and p27{sup Kip1} knockout mice showed failure in the cell cycle exit at G1-phase, and endoreplication. These results indicate that p21{sup Cip1} and p27{sup Kip} play important roles in the cell cycle exit of postnatal cardiomyocytes.

  19. Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of Tenckhoff catheters, in the pediatric population of a dialysis program.

    Science.gov (United States)

    Mendoza-Guevara, L; Castro-Vazquez, F; Aguilar-Kitsu, A; Morales-Nava, A; Rodriguez-Leyva, F; Sanchez-Barbosa, J L

    2007-01-01

    Although, decreasing in incidence with the disconnection systems, the first complication is still peritonitis in patients with chronic renal failure and the second is infection of Tenckhoff catheter exit-site. All efforts made to diminish the frequency of exit-site infection lower the possibility of peritonitis. The pediatric population is well-known to have a major risk of infectious complications, and making easy and safe the care of the exit-site will prevent the peritonitis that follows. The aim of the study was to evaluate the efficacy of the Amuchina 10% solution vs. pH neutral soap in children with chronic renal failure, on preventing exit-site infection. There were 60 patients who were assigned randomly to one of two groups. One group used Amuchina 10% solution for the daily cleaning of the exit-site, and the other used pH neutral soap, with 14 months of follow-up. Before the study they have to be free of infection for at least 30 days. All were taught by the same nurse how to clean their exit-site. Groups were almost identical in years, sex, and time on dialysis. We had nine infections in the soap group and none in the Amuchina 10% solution group, with an OR: 17 (p = 0.004). From these nine infections, the bacteria isolated were: 4 (13%) were caused by Pseudomona aeruginosa, 1 (3.3%) by Staphylococcus aureus, coagulase-positive staphylococci in 2 (6.6%) and Serratia marcensens in 1 (3.3%). In conclusion, Amuchina 10% solution is effective in preventing infection on the exit-site, without any secondary topical reaction.

  20. Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of Tenckhoff catheters, in the pediatric population of a dialysis program.

    Science.gov (United States)

    Mendoza-Guevara, L; Castro-Vazquez, F; Aguilar-Kitsu, A; Morales-Nava, A; Rodriguez-Leyva, F; Sanchez-Barbosa, J L

    2007-01-01

    Although, decreasing in incidence with the disconnection systems, the first complication is still peritonitis in patients with chronic renal failure and the second is infection of Tenckhoff catheter exit-site. All efforts made to diminish the frequency of exit-site infection lower the possibility of peritonitis. The pediatric population is well-known to have a major risk of infectious complications, and making easy and safe the care of the exit-site will prevent the peritonitis that follows. The aim of the study was to evaluate the efficacy of the Amuchina 10% solution vs. pH neutral soap in children with chronic renal failure, on preventing exit-site infection. There were 60 patients who were assigned randomly to one of two groups. One group used Amuchina 10% solution for the daily cleaning of the exit-site, and the other used pH neutral soap, with 14 months of follow-up. Before the study they have to be free of infection for at least 30 days. All were taught by the same nurse how to clean their exit-site. Groups were almost identical in years, sex, and time on dialysis. We had nine infections in the soap group and none in the Amuchina 10% solution group, with an OR: 17 (p = 0.004). From these nine infections, the bacteria isolated were: 4 (13%) were caused by Pseudomona aeruginosa, 1 (3.3%) by Staphylococcus aureus, coagulase-positive staphylococci in 2 (6.6%) and Serratia marcensens in 1 (3.3%). In conclusion, Amuchina 10% solution is effective in preventing infection on the exit-site, without any secondary topical reaction. PMID:17099309

  1. Accuracy of wind tunnel modeling of buoyant plume rise around buildings

    International Nuclear Information System (INIS)

    Dispersion modeling of buoyant exhausts in the vicinity of building clusters, such as from boilers, incinerators, and diesel generators, is often conducted using wind tunnel modeling. The receptors of interest are usually air intakes within the building clusters. Exact wind tunnel modeling of buoyant plume rise requires stack exhaust Froude number scaling between model simulations and the full scale, along with undistorted exit densities and ratios of exit velocity to approach wind speed. The Froude number requirements constrains the air speed in the tunnel to be lower than 0.5 m/s for typical geometric scale reductions. Such low air speeds can make the air flow around the buildings Reynolds number dependent, an undesirable result. Distortions of exhaust density ratios and of exit diameters have been suggested in the past to maintain higher tunnel speeds. Davidson has presented an analytical plume rise equation which combines the 1/3 and 2/3 exponent laws for momentum-dominated and buoyancy-dominated plume rise. The analytical model was reported to compare well with water flume data. Davidson also recommends that the equation can be used to predict the errors in modeled plume rise when various wind tunnel modeling schemes are used to avoid the Froude number modeling requirement. This paper extends the work of Davidson by comparing the analytical equation to several wind tunnel and field plume rise databases. The analytical equation is then used to examine wind tunnel modeling schemes for two types of buoyant exhausts commonly modeled near buildings: emergency diesel generators and boilers

  2. Building for animal production

    International Nuclear Information System (INIS)

    In order to limit the radiation dose to persons working with animal husbandry in severe fallout situations, it was considered necessary to make an inventory of the Swedish livestock buildings as to number, location, use and size. These data as well as data on geometry of buildings, building material and thickness of the material in walls and roofs are given in the present work. On the basis of the mentioned data, calculations were made of the shielding factors of different types of livestock buildings. The collected data can also be used in preparedness planning in relation to housing facilities for livestock and location and size of animal production in situations of crises or war. The calculations show shielding factors for different types of livestock buildings of normal ground area within the range of 0.18-0.71. The higher value indicates a fairly poor shielding effect. The inventory and the calculations show that in those regions in Sweden where the main part of the livestock is managed, the types of buildings are, however, characterized by radiation shielding factors of 0.3-0.4. Calculation were also made of the radiation level inside the buildings following decontamination of roofs or of surrounding ground. Ground decontamination only, i.e., removal of the upper contaminated surface layer, will reduce the radiation level inside the building. For most buildings the radius of the surrounding area to be decontaminated has to be 15-30 times larger than the width of the building in order to achieve a 50 percentage reduction of the radiation level inside the building. For buildings of medium or large size and with thick walls the radiation contribution from the roof is greater than the radiation from the ground, and regardless of the size of the ground areas decontaminated the radiation level inside these buildings will only be reduced by 20-30%. 15 refs, 11 figs, 14 tabs

  3. Ventilation and infiltration in high-rise apartment buildings

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.C.; Feustel, H.E.; Dickerhoff, D.J.

    1996-03-01

    Air flow, air leakage measurements and numerical simulations were made on a 13-story apartment building to characterize the ventilation rates for the individual apartments. Parametric simulations were performed for specific conditions, e.g., height, orientation, outside temperature and wind speed. Our analysis of the air flow simulations suggest that the ventilation to the individual units varies considerably. With the mechanical ventilation system disabled and no wind, units at the lower level of the building have adequate ventilation only on days with high temperature differences, while units on higher floors have no ventilation at all. Units facing the windward side will be over-ventilated when the building experiences wind directions between west and north. At the same time, leeward apartments did not experience any fresh air-because, in these cases, air flows enter the apartments from the corridor and exit through the exhaust shafts and the cracks in the facade. Even with the mechanical ventilation system operating, we found wide variation in the air flows to the individual apartments. In addition to the specific case presented here, these findings have more general implications for energy retrofits and health and comfort of occupants in high-rise apartment buildings.

  4. 上海金桥停车场列车出场能力研究%Study on Train Exit Capacity of Jinqiao Depot in Shanghai Metro

    Institute of Scientific and Technical Information of China (English)

    刘新平

    2012-01-01

    列车的出入场能力需要与正线的运营能力相匹配,与正线列车的运行间隔相适应。通过停车场列车出场方案的研究,以提高列车出场效率为目的,对上海金桥停车场列车出场方案进行了能力分析计算,推荐采用增设发车进路信号机方案,使列车出场能力达到与正线列车运行间隔相匹配的效果%The depot entry exit capability should match the operation capacity of the main lines and accommodate to the intervals of train operation on the main lines.Through a case study of depot exit program,an analysis and calculation of exit capacity of Jinqiao Depot in Shanghai metro was made to enhance the exit efficiency and it was recommended that additional departure route signal be set up to attain the exit capability in match with the intervals of train operation on the main lines.

  5. Building perservation practice

    DEFF Research Database (Denmark)

    Pilegaard, Marie Kirstine

    of architects and planners is primarily to reconcile the conservation prospects with the future use of buildings and sites. They intermediary the site through selections of the narratives, and in practice the restoration or transformation projects becomes a communication of the selected story, utilized...... planning? In this paper I will focus on the communication of the architects working with building preservation and planning, how they communicate the building, the interventions and the storytelling in practice. The methods used by the architects are based on a practice, where some skills are learned...... through education, such as documentation of buildings and the restoration as a way of communicating the architect's intervention on the building, meanwhile the communication of the buildings history is seen as a "natural" skill and the methods are not questioned in the practice. The storytelling has today...

  6. Sustainable Building Operation

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    2009-01-01

    Energy-savings in the existing building stock have becomes a main goal in national and international policies. Often focus is on building-renovations, whereas the potential of sustainable building operation to a large extent has been neglected. Nevertheless, international research as well...... as practical experiences from Danish housing estates indicates that there are large potentials for energy savings by focusing on the operation of the buildings. We suggest that in order to achieve sustainability in the existing housing, renovation and operations should be seen as integrated parts...... building operation as an 'umbrella' for various ways of reducing flows of energy, water and waste in the daily operation of the buildings, for instance by regular monitoring the consumption, by using 'green accounting', by applying policies for sustainability etc. The paper is based on case studies...

  7. Alternative methods for evaluation of airtightness of the building envelope; Alternativa metoder foer utvaerdering av byggnadsskalets lufttaethet

    Energy Technology Data Exchange (ETDEWEB)

    Sikander, Eva; Wahlgren, Paula

    2008-07-01

    Airtightness plays an important role when constructing energy efficient, sustainable and healthy buildings. In order to obtain airtight buildings, the airtightness needs to be evaluated during the construction phase. This enables improvements of the airtightness in an easy and cost-efficient way. During the construction phase, it is difficult to quantify the airtightness. However, detecting and sealing air leakages are good measures to improve the airtightness of the building. Several methods to detect air leakages are presented. A methodology to search for air leakages in buildings during construction has been developed, together with contractors and experts, and the methodology has been used at two building sites. The quantifiable airtightness of a building is determined by measuring the airflow that enters or exits the building at a certain pressure difference over the building envelope. In some cases it is not possible to measure air tightness according to standard. Therefore, a number of alternative methods have been evaluated. These methods include: extrapolation of measured data to a range used in standard measurements, using a buildings ventilation system fans to create a pressure difference over the building envelope, measuring the airtightness of a smaller part of the building (apartment, fire compartment or component) and tracer gas measurements

  8. Capacity Building in Vietnam

    OpenAIRE

    Adam McCarty

    2001-01-01

    This report is the outcome of a study commissioned to examine the capacity building needs in Vietnam, and is a supplementary document to the Asian Development Bank's Country Operational Strategy for Vietnam. Vietnam's needs in terms of capacity building are particularly important given that is it a transitional economy and also one with little institutional experience in dealing with the international donor community. This paper examines the international awareness of capacity building and ca...

  9. Development of Ecological Buildings

    Directory of Open Access Journals (Sweden)

    Andrius Keizikas

    2011-04-01

    Full Text Available The article presents research on ecological buildings and their influence on the constructional sphere. The aim of the paper is to reveal the essence of ecological architecture showing substantial progress and its potential to stimulate architectural and technological growth. The article also describes relations between the ideas of ecological buildings and the ‘passive house’ concepts and aspects of development as well as describes the possibilities of improving building sustainability and energy efficiency. Article in Lithuanian

  10. A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2.

    Science.gov (United States)

    Zaarour, Nancy; Demaretz, Sylvie; Defontaine, Nadia; Mordasini, David; Laghmani, Kamel

    2009-08-01

    Mutations in the apically located Na(+)-K(+)-2Cl(-) co-transporter, NKCC2, lead to type I Bartter syndrome, a life-threatening kidney disorder, yet the mechanisms underlying the regulation of mutated NKCC2 proteins in renal cells have not been investigated. Here, we identified a trihydrophobic motif in the distal COOH terminus of NKCC2 that was required for endoplasmic reticulum (ER) exit and surface expression of the co-transporter. Indeed, microscopic confocal imaging showed that a naturally occurring mutation depriving NKCC2 of its distal COOH-terminal region results in the absence of cell surface expression. Biotinylation assays revealed that lack of cell surface expression was associated with abolition of mature complex-glycosylated NKCC2. Pulse-chase analysis demonstrated that the absence of mature protein was not caused by reduced synthesis or increased rates of degradation of mutant co-transporters. Co-immunolocalization experiments revealed that these mutants co-localized with the ER marker protein-disulfide isomerase, demonstrating that they are retained in the ER. Cell treatment with proteasome or lysosome inhibitors failed to restore the loss of complex-glycosylated NKCC2, further eliminating the possibility that mutant co-transporters were processed by the Golgi apparatus. Serial truncation of the NKCC2 COOH terminus, followed by site-directed mutagenesis, identified hydrophobic residues (1081)LLV(1083) as an ER exit signal necessary for maturation of NKCC2. Mutation of (1081)LLV(1083) to AAA within the context of the full-length protein prevented NKCC2 ER exit independently of the expression system. This trihydrophobic motif is highly conserved in the COOH-terminal tails of all members of the cation-chloride co-transporter family, and thus may function as a common motif mediating their transport from the ER to the cell surface. Taken together, these data are consistent with a model whereby naturally occurring premature terminations that interfere with

  11. Research on Double-Weighted Graph Model and Optimal Path Planning for Intelligent Tourism Navigation Considering Entrances and Exits%面向智能导游的双加权图模型及其路径规划

    Institute of Scientific and Technical Information of China (English)

    史永; 龙毅; 陈林; 吴小玲

    2014-01-01

    When visiting multiple tourist scenic spots, a recommended travel line is usually the most effective route designed for tourists according to the actual road situations. In the field of intelligent tourism navigation, a traditional recommended travel line is mainly generated by path planning algorithm automatically, considering thescenic spots’positions and road networks based on graph model. Normally, the traditional algorithms firstly map scenic spots (which belong to certain scenic area) into points of interests (POIs),and map the road network that links these POIs into a line collection, then build the corresponding graph model. But when a scenic spot has a limited area and involves multiple entrances or exits(for example buildings with multiple indoor space), the tra-ditional described mechanism for single point coordinates is difficult to reflect these structural features. In reali-ty, scenic area path planning is widely applied in the field of mobile tourism guide recently, especially for pedes-trians. There exist significant differences between theoretical optimal paths and actual optimal paths, sincetourist-sare inclined to have more choices. In order to solve this problem, this paper analyzed various influences on the process of path planning, caused by scenic spots’own structural features (such as the size, shape and entrance), and focused on the influences of multiple entrances or exits located within the scenic area. Then,we proposed a Double-Weighted Graph Model considering multiple entrances and exits for tourist scenic area, and the weights of both vertexes and edges of the proposed model can be selected and weighted dynamically. Next, we discussed the building method for the model, and proposed an optimal path planning algorithm based on Dijkstra algorithm and Prim algorithm. Experimental results show that the optimal planned travel line derived from this proposed model and algorithms is considerably reasonable, and the travelling order and

  12. Building valve amplifiers

    CERN Document Server

    Jones, Morgan

    2013-01-01

    Building Valve Amplifiers is a unique hands-on guide for anyone working with tube audio equipment--as an electronics hobbyist, audiophile or audio engineer. This 2nd Edition builds on the success of the first with technology and technique revisions throughout and, significantly, a major new self-build project, worked through step-by-step, which puts into practice the principles and techniques introduced throughout the book. Particular attention has been paid to answering questions commonly asked by newcomers to the world of the valve, whether audio enthusiasts tackling their first build or

  13. Healthy Buildings '88

    International Nuclear Information System (INIS)

    The Healthy Buildings '88 Conference focuses on the technical solutions and functional requirements contributing to Healthy Buildings for people to live and work in. The main object of the Conference is to give architects, consultants, real-estate owners and manufacturers of building materials recommendations on choice of materials and choice of systems and on how to combine materials and systems. The program includes overview lectures, plenary symposia with invited speakers, workshops, poster presentations and an exhibition of scientific, educational and technical material. One part of the conference is devoted to the problem of radon in residential buildings

  14. Sick building syndrome

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2002-06-01

    Full Text Available Sick building syndrome describes a number of mostly unspesific complaints of some occupants of the building. The exact pathophysiological mechanism remains elusive. It is a multi factorial event which may include physical, chemical, biological as well as psycological factors. In many cases it is due to insufficient maintenance of the HVAC (heating, ventilation, air conditioning system in the building. Sign and symptoms can be uncomfortable and even disabling, which may include mucus membrane irritation, neurotoxic symptoms, asthma like symptoms, skin complaints, gastrointestinal symptoms and other related symptoms. There are various investigation methods to diagnose sick building syndrome, and on site assessment of the building is extremely useful. Prevention through a proactive air quality monitoring program is far more desirable than dealing with an actual sick building. Indoor air and the sick building symdrome serves as a paradigm of modern occupational and environmental medicine. (Med J Indones 2002; 11:124-31Keywords: indoor air pollution, sick building syndrome, building related illness

  15. A firm-level dataset for analyzing entry, exit, employment and R&D expenditures in the UK: 1997-2012.

    Science.gov (United States)

    Ugur, Mehmet; Trushin, Eshref; Solomon, Edna

    2016-09-01

    This data article is related to the research article entitled "Inverted-U relationship between R&D intensity and survival: Evidence on scale and complementarity effects in UK data" (Ugur et al., In press) [1]. It describes the trends in R&D expenditures, employment of R&D personnel and firm entry and exit rates in the UK from 1998 to 2012. We also provide statistics on net employment creation and net R&D investments due to firm entry and exits. In addition, we compute the correlation coefficients between entry and exit rates at the two digit industry level so as to examine whether the correlations are contemporaneous or inter-temporal. Finally, we provide information about the underlying dataset to which secure access is available through UK Data Service Archive 7716 at http://dx.doi.org/10.5255/UKDA-SN-7716-1. PMID:27294184

  16. Determining when a set of compute nodes participating in a barrier operation on a parallel computer are ready to exit the barrier operation

    Science.gov (United States)

    Blocksome, Michael A.

    2011-12-20

    Methods, apparatus, and products are disclosed for determining when a set of compute nodes participating in a barrier operation on a parallel computer are ready to exit the barrier operation that includes, for each compute node in the set: initializing a barrier counter with no counter underflow interrupt; configuring, upon entering the barrier operation, the barrier counter with a value in dependence upon a number of compute nodes in the set; broadcasting, by a DMA engine on the compute node to each of the other compute nodes upon entering the barrier operation, a barrier control packet; receiving, by the DMA engine from each of the other compute nodes, a barrier control packet; modifying, by the DMA engine, the value for the barrier counter in dependence upon each of the received barrier control packets; exiting the barrier operation if the value for the barrier counter matches the exit value.

  17. A firm-level dataset for analyzing entry, exit, employment and R&D expenditures in the UK: 1997-2012.

    Science.gov (United States)

    Ugur, Mehmet; Trushin, Eshref; Solomon, Edna

    2016-09-01

    This data article is related to the research article entitled "Inverted-U relationship between R&D intensity and survival: Evidence on scale and complementarity effects in UK data" (Ugur et al., In press) [1]. It describes the trends in R&D expenditures, employment of R&D personnel and firm entry and exit rates in the UK from 1998 to 2012. We also provide statistics on net employment creation and net R&D investments due to firm entry and exits. In addition, we compute the correlation coefficients between entry and exit rates at the two digit industry level so as to examine whether the correlations are contemporaneous or inter-temporal. Finally, we provide information about the underlying dataset to which secure access is available through UK Data Service Archive 7716 at http://dx.doi.org/10.5255/UKDA-SN-7716-1.

  18. [A way of helping "Mr. Minotaur" and "Ms. Ariadne" to exit from the multiple morbidity labyrinth: the "master problems"].

    Science.gov (United States)

    Turabián, J L; Pérez Franco, B

    2016-01-01

    Multiple morbidity seems to be "infinite" and so is not easy to make useful decisions. A new concept is introduced: the "master problems", as a qualitative method to facilitate the exit from this maze of multiple morbidity. Metaphors from the art world have been used to teach this concept. These "master problems" generally remain hidden and can only "unravel" between the interstices of multiple morbidity, when the details of the system that defines the problem are explained. A problem with "energy" or a "master problem" is complex, multiple and dramatic or theatrical--everything in the clinical history history make us look into that particular question. It is what gives us a blow to the stomach, which causes our hearts to beat faster, that moves us on many levels, which has a high "density of emotions", human elements, social symbols, and opens solutions in a patient.

  19. A Study on the Effect of Exit Widths and Crowd Sizes in the Formation of Arch in Clogged Crowds

    CERN Document Server

    Castro, Francisco Enrique Vicente G

    2015-01-01

    The arching phenomenon is an emergent pattern formed by a $c$-sized crowd of intelligent, goal-oriented, autonomous, heterogeneous individuals moving towards a $w$-wide exit along a long $W$-wide corridor, where $W>w$. We collected empirical data from microsimulations to identify the combination effects of~$c$ and~$w$ to the time~$T$ of the onset of and the size~$S$ of the formation of the arch. The arch takes on the form of the perimeter of a half ellipse halved along the minor axis. We measured the~$S$ with respect to the lengths of the major~$M$ and minor~$m$ axes of the ellipse, respectively. The mathematical description of the formation of this phenomenon will be an important information in the design of walkways to control and easily direct the flow of large crowds, especially during panic egress conditions.

  20. CCR1, an enzyme required for lignin biosynthesis in Arabidopsis, mediates cell proliferation exit for leaf development

    DEFF Research Database (Denmark)

    Xue, Jingshi; Luo, Dexian; Xu, Deyang;

    2015-01-01

    exit in leaves. CCR1 is expressed basipetally in the leaf, and ccr1 mutants exhibited multiple abnormalities, including increased cell proliferation. The ccr1 phenotypes are not due to the reduced lignin content, but instead are due to the dramatically increased level of ferulic acid (FeA......), an intermediate in lignin biosynthesis. FeA is known to have antioxidant activity, and the levels of reactive oxygen species (ROS) in ccr1 were markedly reduced. We also characterized another double mutant in CAFFEIC ACID O-METHYLTRANSFERASE (comt) and CAFFEOYL CoA 3-O-METHYLTRANSFERASE (ccoaomt), in which the FeA...... level was dramatically reduced. Cell proliferation in comt ccoaomt leaves was decreased, accompanied by elevated ROS levels, and the mutant phenotypes were partially rescued by treatment with FeA or another antioxidant (N-acetyl-L-cysteine). Taken together, our results suggest that CCR1, FeA and ROS...

  1. lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs.

    Science.gov (United States)

    Savić, Nataša; Bär, Dominik; Leone, Sergio; Frommel, Sandra C; Weber, Fabienne A; Vollenweider, Eva; Ferrari, Elena; Ziegler, Urs; Kaech, Andres; Shakhova, Olga; Cinelli, Paolo; Santoro, Raffaella

    2014-12-01

    The open chromatin of embryonic stem cells (ESCs) condenses into repressive heterochromatin as cells exit the pluripotent state. How the 3D genome organization is orchestrated and implicated in pluripotency and lineage specification is not understood. Here, we find that maturation of the long noncoding RNA (lncRNA) pRNA is required for establishment of heterochromatin at ribosomal RNA genes, the genetic component of nucleoli, and this process is inactivated in pluripotent ESCs. By using mature pRNA to tether heterochromatin at nucleoli of ESCs, we find that localized heterochromatin condensation of ribosomal RNA genes initiates establishment of highly condensed chromatin structures outside of the nucleolus. Moreover, we reveal that formation of such highly condensed, transcriptionally repressed heterochromatin promotes transcriptional activation of differentiation genes and loss of pluripotency. Our findings unravel the nucleolus as an active regulator of chromatin plasticity and pluripotency and challenge current views on heterochromatin regulation and function in ESCs.

  2. Development and applications of grazing exit micro X-ray fluorescence instrument using a polycapillary X-ray lens

    International Nuclear Information System (INIS)

    A polycapillary X-ray lens is an effective optics to obtain a μm-size X-ray beam for micro-X-ray fluorescence spectrometry (μ-XRF). We developed a μ-XRF instrument using a polycapillary X-ray lens, which also enabled us to perform Grazing Exit μ-XRF (GE-μ-XRF). The evaluated diameter of the primary X-ray beam was 48 μm at the focal distance of the X-ray lens. Use of this instrument enabled two-dimensional mapping of the elemental distributions during growth of the plant 'Quinoa'. The results of the mapping revealed elemental transition during growth. In addition, a small region of thin film was analyzed by GE-μ-XRF. We expect that GE-μ-XRF will become an effective method of estimating the film thickness of a small region

  3. Development and applications of grazing exit micro X-ray fluorescence instrument using a polycapillary X-ray lens*1

    Science.gov (United States)

    Emoto, T.; Sato, Y.; Konishi, Y.; Ding, X.; Tsuji, K.

    2004-08-01

    A polycapillary X-ray lens is an effective optics to obtain a μm-size X-ray beam for micro-X-ray fluorescence spectrometry (μ-XRF). We developed a μ-XRF instrument using a polycapillary X-ray lens, which also enabled us to perform Grazing Exit μ-XRF (GE-μ-XRF). The evaluated diameter of the primary X-ray beam was 48 μm at the focal distance of the X-ray lens. Use of this instrument enabled two-dimensional mapping of the elemental distributions during growth of the plant "Quinoa". The results of the mapping revealed elemental transition during growth. In addition, a small region of thin film was analyzed by GE-μ-XRF. We expect that GE-μ-XRF will become an effective method of estimating the film thickness of a small region.

  4. Postextrasystolic sinoatrial exit block in human sick sinus syndrome: demonstration by direct recording of sinus node electrograms.

    Science.gov (United States)

    Asseman, P; Berzin, B; Desry, D; Bauchart, J J; Reade, R; Leroy, O; Poncelet, P; Lekieffre, J; Thery, C

    1991-12-01

    Ten patients with sick sinus syndrome having repetitive sinus node electrograms during long postpacing pauses were studied during programmed atrial stimulation. Sinus node activity was recorded using a percutaneous catheter electrode. A sinus node electrogram was recorded before the return atrial beat in seven patients; it was similar to the sinus node electrogram observed during postpacing pauses and is clearly identified because sinoatrial conduction time was markedly prolonged following the atrial extra beat. Complete sinoatrial exit block occurred in four patients. (1) Sinus node electrograms were thus validated both during postpacing pauses and during programmed atrial stimulation in most patients with sick sinus syndrome. (2) Sinoatrial conduction time was markedly prolonged after one extrasystole, accounting for supracompensatory atrial return cycles. (3) If it were cumulative following multiple extrasystoles, this effect could constitute the electrophysiologic link between an abnormal response during programmed atrial stimulation and the complete sinoatrial block recorded during the pauses that follow rapid atrial pacing.

  5. Development and applications of grazing exit micro X-ray fluorescence instrument using a polycapillary X-ray lens

    Energy Technology Data Exchange (ETDEWEB)

    Emoto, T.; Sato, Y.; Konishi, Y.; Ding, X.; Tsuji, K. E-mail: tsuji@a-chem.eng.osaka-cu.ac.jp

    2004-08-31

    A polycapillary X-ray lens is an effective optics to obtain a {mu}m-size X-ray beam for micro-X-ray fluorescence spectrometry ({mu}-XRF). We developed a {mu}-XRF instrument using a polycapillary X-ray lens, which also enabled us to perform Grazing Exit {mu}-XRF (GE-{mu}-XRF). The evaluated diameter of the primary X-ray beam was 48 {mu}m at the focal distance of the X-ray lens. Use of this instrument enabled two-dimensional mapping of the elemental distributions during growth of the plant 'Quinoa'. The results of the mapping revealed elemental transition during growth. In addition, a small region of thin film was analyzed by GE-{mu}-XRF. We expect that GE-{mu}-XRF will become an effective method of estimating the film thickness of a small region.

  6. Influence of selfish and polite behaviours on a pedestrian evacuation through a narrow exit: A quantitative characterisation

    CERN Document Server

    Nicolas, Alexandre; Kuperman, Marcelo

    2016-01-01

    We study the influence of selfish vs. polite behaviours on the dynamics of a pedestrian evacuation through a narrow exit. To this end, experiments involving about 80 participants with distinct prescribed behaviours are performed; reinjection of participants into the setup allowed us to improve the statistics. Notwithstanding the fluctuations in the instantaneous flow rate, we find that a stationary regime is almost immediately reached. The average flow rate increases monotonically with the fraction c\\_s of vying (selfish) pedestrians, which corresponds to a "faster-is-faster" effect in our experimental conditions; it is also positively correlated with the average density of pedestrians in front of the door, up to nearly close-packing. At large c\\_s , the flow displays marked intermittency, with bursts of quasi-simultaneous escapes. In addition to these findings, we wonder whether the effect of cooperation is specific to systems of intelligent beings, or whether it can be reproduced by a purely mechanical surr...

  7. Feedback from each retinal neuron population drives expression of subsequent fate determinant genes without influencing the cell cycle exit timing.

    Science.gov (United States)

    Kei, Jeremy Ng Chi; Dudczig, Stefanie; Currie, Peter D; Jusuf, Patricia R

    2016-09-01

    During neurogenesis, progenitors balance proliferation and cell cycle exit together with expression of fate determinant genes to ensure that the correct number of each of these neuron types is generated. Although intrinsic gene expression acting cell autonomously within each progenitor drives these processes, the final number of neurons generated is also influenced by extrinsic cues, representing a potential avenue to direct neurogenesis in developmental disorders or regenerative settings without the requirement to change intrinsic gene expression. Thus, it is important to understand which of these stages of neurogenesis are amenable to such extrinsic influences. Additionally, all types of neurons are specified in a highly conserved histogenic order, although its significance is unknown. This study makes use of conserved patterns of neurogenesis in the relatively simple yet highly organized zebrafish retina model, in which such histogenic birth order is well characterized. We directly visualize and quantify birth dates and cell fate determinant expression in WT vs. environments lacking different neuronal populations. This study shows that extrinsic feedback from developing retinal neurons is important for the temporal expression of intrinsic fate determinants but not for the timing of birth dates. We found no changes in cell cycle exit timing but did find a significant delay in the expression of genes driving the generation only of later- but not earlier-born cells, suggesting that the robustness of this process depends on continuous feedback from earlier-formed cell types. Thus, extrinsic cues selectively influence cell fate determinant progression, which may explain the function of the retinal histogenic order observed. J. Comp. Neurol. 524:2553-2566, 2016. © 2016 Wiley Periodicals, Inc. PMID:26850379

  8. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex.

    Directory of Open Access Journals (Sweden)

    Qingyu Li

    Full Text Available The radial migration of neuronal progenitor cells is critical for the development of cerebral cortex layers. They go through a critical step transforming from multipolar to bipolar before outward migration. A Disintegrin and Metalloprotease 17 (ADAM17 is a transmembrane protease which can process many substrates involved in cell-cell interaction, including Notch, ligands of EGFR, and some cell adhesion molecules. In this study, we used in utero electroporation to knock down or overexpress ADAM17 at embryonic day 14.5 (E14.5 in neuronal progenitor cells to examine the role of ADAM17 in cortical embryonic neurogenesis. Our results showed that the radial migration of ADAM17-knocked down cells were normal till E16.5 and reached the intermediate zone (IZ. Then most transfected cells stopped migration and stayed at the IZ to inner cortical plate (CP layer at E18.5, and there was higher percentage of multipolar cells at IZ layer in the ADAM17-knocked down group compared to the cells in control group. Marker staining revealed that those ADAM17-knocked down cells differentiated normally from neural stem cells (NSCs to neuronal intermediate progenitor cells (nIPCs but did not differentiate into mature neurons. The migration and multipolar exit defects caused by ADAM17 knockdown could be partially rescued by over-expressing an shRNA resistant ADAM17, while overexpressing ADAM17 alone did not affect the radial migration. Taken together, our results showed for the first time that, ADAM17 is critical in regulating the multipolar-stage exit and radial migration of the nIPCs during telencephalon cortex development in mice.

  9. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex.

    Science.gov (United States)

    Li, Qingyu; Zhang, Zhengyu; Li, Zengmin; Zhou, Mei; Liu, Bin; Pan, Le; Ma, Zhixing; Zheng, Yufang

    2013-01-01

    The radial migration of neuronal progenitor cells is critical for the development of cerebral cortex layers. They go through a critical step transforming from multipolar to bipolar before outward migration. A Disintegrin and Metalloprotease 17 (ADAM17) is a transmembrane protease which can process many substrates involved in cell-cell interaction, including Notch, ligands of EGFR, and some cell adhesion molecules. In this study, we used in utero electroporation to knock down or overexpress ADAM17 at embryonic day 14.5 (E14.5) in neuronal progenitor cells to examine the role of ADAM17 in cortical embryonic neurogenesis. Our results showed that the radial migration of ADAM17-knocked down cells were normal till E16.5 and reached the intermediate zone (IZ). Then most transfected cells stopped migration and stayed at the IZ to inner cortical plate (CP) layer at E18.5, and there was higher percentage of multipolar cells at IZ layer in the ADAM17-knocked down group compared to the cells in control group. Marker staining revealed that those ADAM17-knocked down cells differentiated normally from neural stem cells (NSCs) to neuronal intermediate progenitor cells (nIPCs) but did not differentiate into mature neurons. The migration and multipolar exit defects caused by ADAM17 knockdown could be partially rescued by over-expressing an shRNA resistant ADAM17, while overexpressing ADAM17 alone did not affect the radial migration. Taken together, our results showed for the first time that, ADAM17 is critical in regulating the multipolar-stage exit and radial migration of the nIPCs during telencephalon cortex development in mice. PMID:23755270

  10. Buildings for Education.

    Science.gov (United States)

    Asian Regional Inst. for School Building Research, Colombo (Sri Lanka).

    The quarterly review for October and December 1967 of the Asian Regional Institute for School Building Research at Colombo, Ceylon--(1) reviews two main activities of a cost and space utilization study and a report of the workshop of the directors and UNESCO experts on regional educational buildings, (2) describes a method for determining teacher…

  11. Building a Better Robot

    Science.gov (United States)

    Navah, Jan

    2012-01-01

    Kids love to build robots, letting their imaginations run wild with thoughts of what they might look like and what they could be programmed to do. Yet when students use cereal boxes and found objects to make robots, often the projects look too similar and tend to fall apart. This alternative allows students to "build" robots in a different way,…

  12. Building: Food for thought

    Directory of Open Access Journals (Sweden)

    Efraïm Rodríguez

    2011-05-01

    Full Text Available The sculpture presented by Efraïm Rodríguez for the conference is titled “pequeño arquitecto” (The Little Architect, a figure which represents a child building a tower with pieces of classical children’s block building toys; the child itself is built out of the same sculpted materials.

  13. Building Numbers from Primes

    Science.gov (United States)

    Burkhart, Jerry

    2009-01-01

    Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…

  14. Electromagnetically shielded building

    International Nuclear Information System (INIS)

    This invention relates to a building having an electromagnetic shield structure well-suited for application to an information network system utilizing electromagnetic waves, and more particularly to an electromagnetically shielded building for enhancing the electromagnetic shielding performance of an external wall. 6 figs

  15. School Building Defect Pattern

    Directory of Open Access Journals (Sweden)

    Mahli M.

    2014-01-01

    Full Text Available In providing a conducive learning environment for the student, the school building must be in good condition. This paper is evaluating the existing condition of primary school building in Sarawak, Malaysia. It focuses on building defects pattern for school building. The primary data collection is from the school building condition survey with involvement of 24 primary schools. The schools have been selected using simple random sampling and stratified sampling (of school age as the variable of selection. The reporting method is based on Condition Survey Protocol (CSP 1 Matrix. Data analysis covers descriptive and inferential statistics. The analysis carried out found that the overall 4,725 defects have been identified. The building defect pattern is mainly on Ground Level of 3,176 defects, the highest number of defects components found on walls (798. 16.2% defects are cracks from 11 common defects and most of all the highest score of defects based on age of the building were the building in the range of 11 to 20 years.

  16. Integrated Building Design

    DEFF Research Database (Denmark)

    Heiselberg, Per

    In the first half of the 20th century, HVAC systems and artificial lighting were developed to meet indoor comfort needs. Before the introduction of mechanical systems, climate - not building style or appearance - was the major determinant of building form. Comfort was achieved through passive means...

  17. Heat loss from Buildings

    DEFF Research Database (Denmark)

    Karlsson, Kenneth; Næraa, Rikke

    1997-01-01

    Determination of heat loss coefficients for buildings in Denmark. The coefficient are determined for 15 building groups and 3 year intervals. They are based on the BBR-registre and assumptions of U-values(W/K*m2)and computed in a simple spreed sheet model.The results are used in the REVEILLE...... project for calculations in the SESAM model....

  18. Body-building

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正In recent years, more and more people spare no pains to join in the body-building group. People begin to take part in various fitness clubs or fitness centers in their spare time. This shows body-building has become an indispensable part of many people’s life.

  19. Building a Data Warehouse.

    Science.gov (United States)

    Levine, Elliott

    2002-01-01

    Describes how to build a data warehouse, using the Schools Interoperability Framework (www.sifinfo.org), that supports data-driven decision making and complies with the Freedom of Information Act. Provides several suggestions for building and maintaining a data warehouse. (PKP)

  20. LARGE BUILDING RADON MANUAL

    Science.gov (United States)

    The report summarizes information on how bilding systems -- especially the heating, ventilating, and air-conditioning (HVAC) system -- inclurence radon entry into large buildings and can be used to mitigate radon problems. It addresses the fundamentals of large building HVAC syst...

  1. Dancing building prevents collapse

    NARCIS (Netherlands)

    Visscher, R.

    2007-01-01

    In future, anybody caught inside a building during an earthquake need no longer fear the roof collapsing on them. Thanks to the use of composite materials, all the building will do is dance along, riding the waves of the earthquake. At least, according to Professor Ir. Adriaan Beukers of the Aerospa

  2. Hazard Analysis on One—Room Building Fires

    Institute of Scientific and Technical Information of China (English)

    YuDeming; FengChanggen

    1998-01-01

    First,a calculation method for available safety egress time (shortly called ASET) and requirement safety egress time (Shortly called RSET) in a one-room building fire is proposed and a model for predicting the death number caused by the fire is established in this paper,Then,numerical simulations are performed,and the following laws are discovered:(1)At the beginning of the fire,the smoke layer falls slowly;as the fire develops,it falls rapidly.(2) The hypotheses on the fire source,the combustion properties of the combustibles,and the width of the exit and the person number in the room are important factors which affect the death number in the fire.

  3. Energy Performance of Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per

    2007-01-01

    emissions in the coming years. By approving the Energy Performance in Buildings Directive the European Union has taken a strong leadership role in promoting energy efficiency in buildings in Europe, and the Directive will be the most powerful instrument developed to date for the building sector in Europe...... programme (ECCP) was established in June 2000 to help identify the most environmentally cost-effective measures enabling the EU to meet its target under the Kyoto Protocol, namely an 8% reduction in greenhouse gas emissions from 1990 levels by 2012. Energy use in buildings accounts for almost half of all CO......-effective energy saving potential of between 22% and 40% of the energy consumption in the sector by the year 2020. The paper presents the European approach to improve sustainability in the building sector, which has a very high potential for considerable reduction of energy consumption and green house gas...

  4. CERN's newest building

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    With a growing number of users looking for offices, the shortage of space has become acute, particularly for physicists. Building 42, inaugurated on Friday 11 February, offers almost 300 new work-spaces and a particularly pleasant working environment.   Mauro Dell’Ambrogio, the Swiss State Secretary for Education and Research (left), Rolf Heuer , CERN Director-General (centre), and Mark Muller, President of the Government of the Republic and Canton of Geneva and Head of the Department of Construction and Information Technology (right) at the opening of Building 42 on 11 February, 2011.   Construction work for the new Building 42 began in January 2009, thanks to support from the Swiss foundation FIPOI (Fondation des immeubles pour les organisations internationales). After two years of work, the building, an extension of Building 40, is ready to accommodate physicists from around the world who have come to work on the LHC. "We had more than 25 external contractors working...

  5. Knowledge formalization of intelligent building

    Science.gov (United States)

    Žáček, Martin

    2016-06-01

    This article aim is understanding the basic knowledge about an intelligent building. The notion of the intelligent building can be called any building equipped with computer and communication technology, which can automatically respond to internal or external stimuli. The result of the intelligent building is an automated and foreseeing of activities that enable to reduce operating costs and increase comfort. The best way to use the intelligent building is for a low-energy building, a passive building, or for building with high savings. The output of this article is the formalization of basic knowledge of the intelligent building by RDF graph.

  6. Energy management systems in buildings

    Energy Technology Data Exchange (ETDEWEB)

    Lush, D.M.

    1979-07-01

    An investigation is made of the range of possibilities available from three types of systems (automatic control devices, building envelope, and the occupants) in buildings. The following subjects are discussed: general (buildings, design and personnel); new buildings (envelope, designers, energy and load calculations, plant design, general design parameters); existing buildings (conservation measures, general energy management, air conditioned buildings, industrial buildings); man and motivation (general, energy management and documentation, maintenance, motivation); automatic energy management systems (thermostatic controls, optimized plant start up, air conditioned and industrial buildings, building automatic systems). (MCW)

  7. Building Software with Gradle

    CERN Document Server

    CERN. Geneva; Studer, Etienne

    2014-01-01

    In this presentation, we will give an overview of the key concepts and main features of Gradle, the innovative build system that has become the de-facto standard in the enterprise. We will cover task declaration and task graph execution, incremental builds, multi-project builds, dependency management, applying plugins, extracting reusable build logic, bootstrapping a build, and using the Gradle daemon. By the end of this talk, you will have a good understanding of what makes Gradle so powerful yet easy to use. You will also understand why companies like Pivotal, LinkedIn, Google, and other giants with complex builds count on Gradle. About the speakers Etienne is leading the Tooling Team at Gradleware. He has been working as a developer, architect, project manager, and CTO over the past 15 years. He has spent most of his time building software products from the ground up and successfully shipping them to happy customers. He had ...

  8. Building Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Heli Koukkari

    2010-07-01

    Full Text Available Although social, economic, and cultural indicators are of substantial importance to the concept of sustainable building, this concept is usually related to environmental characteristics. Any building level assessment method is complex and involves contradictory aspects. Moreover, emphasizing qualitative criteria only increases confusion. R&D and standardization are thus concentrated to transparency and usability of the environmental methods. Other directions of research aim at performance-based design and methods to take regional and cultural aspects into account. In this paper, the perspectives of the sustainability assessment of a whole building are presented, based on a state of the art, feasibility study on performance analysis and the development of an extended life-cycle assessment for buildings. Using various tools, and based on the case studies of building sustainability assessment, environmental indicators were often shown to be of lesser importance than the other, soft ones. The first steps in the development of a building sustainability assessment method for Portuguese residential buildings will be presented and discussed in the end.

  9. Buildings Interoperability Landscape

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-12-31

    Through its Building Technologies Office (BTO), the United States Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE-EERE) is sponsoring an effort to advance interoperability for the integration of intelligent buildings equipment and automation systems, understanding the importance of integration frameworks and product ecosystems to this cause. This is important to BTO’s mission to enhance energy efficiency and save energy for economic and environmental purposes. For connected buildings ecosystems of products and services from various manufacturers to flourish, the ICT aspects of the equipment need to integrate and operate simply and reliably. Within the concepts of interoperability lie the specification, development, and certification of equipment with standards-based interfaces that connect and work. Beyond this, a healthy community of stakeholders that contribute to and use interoperability work products must be developed. On May 1, 2014, the DOE convened a technical meeting to take stock of the current state of interoperability of connected equipment and systems in buildings. Several insights from that meeting helped facilitate a draft description of the landscape of interoperability for connected buildings, which focuses mainly on small and medium commercial buildings. This document revises the February 2015 landscape document to address reviewer comments, incorporate important insights from the Buildings Interoperability Vision technical meeting, and capture thoughts from that meeting about the topics to be addressed in a buildings interoperability vision. In particular, greater attention is paid to the state of information modeling in buildings and the great potential for near-term benefits in this area from progress and community alignment.

  10. Numerical simulation and exergetic analysis of building ventilation solar chimneys

    International Nuclear Information System (INIS)

    Highlights: • Exergetic analysis of a building ventilation solar chimney. • Numerical CFD model developed, validated and employed to study the flow. • Analysis of the solar chimney energy and exergy efficiencies. • Mechanical and thermal exergy distributions have been analysed. • Crucial points in the chimney identified to improve its performance. - Abstract: The solar chimneys used in buildings are passive solar devices which improve natural ventilation. A detailed exergetic analysis has been developed in this work, both for general balance and specific variables. To apply this analysis, a three-dimensional CFD model has been built and validated with bibliographic experimental data. The values of the variables have been examined both inside and at the exit of the solar chimney, resulting in a detailed description of the inner phenomena and parameters influencing the exergetic efficiency. The results of this study offer new tools: a numerical methodology and an exergetic analysis, to improve the design of building ventilation solar chimneys. It also affords a deeper understanding of the thermal and fluid-dynamic behaviour, and suggests some qualitative improvements. However, the numerical data obtained from the case studied, show that solar chimneys as natural ventilation systems offer quite a small efficiency and will remain within the sphere of architectural decisions

  11. INL Green Building Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer Dalton

    2005-05-01

    Green buildings, also known as sustainable buildings, resource efficient buildings, and high performance buildings, are structures that minimize the impact on the environment by using less energy and water, reducing solid waste and pollutants, and limiting the depletion of natural resources. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish the mission. This infrastructure, particularly the buildings, should incorporate green design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. With this in mind, the recommendations described in this strategy are intended to form the INL foundation for green building standards. The recommendations in this strategy are broken down into three levels: Baseline Minimum, Leadership in Energy and Environmental Design (LEED)Certification, and Innovative. Baseline Minimum features should be included in all new occupied buildings no matter what the purpose or size. These features do not require significant research, design, or capital costs and yet they can reduce Operation and Maintenance (O&M) costs and produce more environmentally friendly buildings. LEED Certification features are more aggressive than the Baseline Minimums in that they require documentation, studies, and/or additional funding. Combined with the Baseline Minimums, many of the features in this level will need to be implemented to achieve the goal of LEED certification. LEED Silver certification should be the minimum goal for all new buildings (including office buildings, laboratories, cafeterias, and visitor centers) greater than 25,000 square feet or a total cost of $10 million. Innovative features can also contribute to LEED certification, but are less mainstream than those listed in the previous two levels. These features are identified as areas where

  12. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...... Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis...

  13. Mycotoxins in building materials

    DEFF Research Database (Denmark)

    Nielsen, Kristian Fog; Frisvad, Jens Christian

    2011-01-01

    as in future energy efficient buildings. It brings together different disciplinary points of view on indoor mold, ranging from physics and material science to microbiology and health sciences. The contents have been outlined according to three main issues: Fundamentals, particularly addressing the crucial...... for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures. This book aims to describe the fundamentals of indoor mold growth as a prerequisite to tackle mold growth in the existing building stock as well...

  14. The corporate brand building

    OpenAIRE

    Wisterová, Veronika

    2011-01-01

    The target of this master's thesis is to follow the process of corporate brand building of the company Starkl zahradník, to analyse it and to suggest possible improvements. The thesis is divided into four main sections. The first section deals with the theoretical aspects of the corporate brand building. The second section observes the process of brand building of the brand Starkl zahradník. The third section deals with the survey that was carried out and analyse its results. This survey was ...

  15. Building Social Web Applications

    CERN Document Server

    Bell, Gavin

    2009-01-01

    Building a web application that attracts and retains regular visitors is tricky enough, but creating a social application that encourages visitors to interact with one another requires careful planning. This book provides practical solutions to the tough questions you'll face when building an effective community site -- one that makes visitors feel like they've found a new home on the Web. If your company is ready to take part in the social web, this book will help you get started. Whether you're creating a new site from scratch or reworking an existing site, Building Social Web Applications

  16. Exploring the Use of Statewide Exit Exams to Spread Innovation--The Example of "Context" in Science Tasks from an International Comparative Perspective

    Science.gov (United States)

    Kuhn, Svenja Mareike

    2011-01-01

    Many innovation-oriented concepts have recently been discussed as means to improve science education and instruction as well as the corresponding tests and exit exams. So far, empirical evidence of whether these new concepts for exam tasks actually find their way into the exam practice is still pending. This contribution takes up this desideratum…

  17. Variation of the cold intermediate water in the Black Sea exit of the Strait of Istanbul (Bosphorus and its transfer through the strait

    Directory of Open Access Journals (Sweden)

    Huseyin Yuce

    2012-04-01

    Full Text Available The cold intermediate water (CIW, T < 8°C entering the Strait of Istanbul and its variation along the strait have been studied by using monthly conductivity-temperature-depth (CTDdata sets collected during the period from 1996 to 2000. In the northern exit of the strait, CIW is located between the seasonal thermocline and Mediterranean water originating from the lowerlayer of the Sea of Marmara. The thickness of CIW decreases fromApril to October. In the Strait of Istanbul, CIW is observedas a layer of temperature < 14$^{circ}$C. The thickness of thismodified cold intermediate water flowing southwards with the upper layer decreases, while its temperature increases along thestrait due to mixing with adjacent water. In the southern exit of the strait, the modified cold intermediate water is observed during the period from May to October. If CIW exists in the Black Sea exit region of the strait, modified cold water is found inthe Marmara exit region during the same period. The distribution of CIW in the Strait of Istanbul contributes to our understanding of the dynamics of the strait, especially in the summer months.

  18. Experimental Investigation of the Effect of Radial Gap and Impeller Blade Exit on Flow-Induced Vibration at the Blade-Passing Frequency in a Centrifugal Pump

    Directory of Open Access Journals (Sweden)

    A. Al-Qutub

    2009-01-01

    Full Text Available It has been recognized that the pressure pulsation excited by rotor-stator interaction in large pumps is strongly influenced by the radial gap between impeller and volute diffusers/tongues and the geometry of impeller blade at exit. This fluid-structure interaction phenomenon, as manifested by the pressure pulsation, is the main cause of flow-induced vibrations at the blade-passing frequency. In the present investigation, the effects of the radial gap and flow rate on pressure fluctuations, vibration, and pump performance are investigated experimentally for two different impeller designs. One impeller has a V-shaped cut at the blade's exit, while the second has a straight exit (without the V-cut. The experimental findings showed that the high vibrations at the blade-passing frequency are primarily raised by high pressure pulsation due to improper gap design. The existence of V-cut at blades exit produces lower pressure fluctuations inside the pump while maintaining nearly the same performance. The selection of proper radial gap for a given impeller-volute combination results in an appreciable reduction in vibration levels.

  19. Justifying the Use of a Second Language Oral Test as an Exit Test in Hong Kong: An Application of Assessment Use Argument Framework

    Science.gov (United States)

    Jia, Yujie

    2013-01-01

    This study employed Bachman and Palmer's (2010) Assessment Use Argument framework to investigate to what extent the use of a second language oral test as an exit test in a Hong Kong university can be justified. It also aimed to help test developers of this oral test identify the most critical areas in the current test design that might need…

  20. Data Analysis and Data-Driven Decision-Making Strategies Implemented by Elementary Teachers in Selected Exited Program Improvement Safe Harbor Schools in Southern California

    Science.gov (United States)

    Senger, Karen

    2012-01-01

    Purpose: The purposes of this study were to investigate and describe how elementary teachers in exited Program Improvement-Safe Harbor schools acquire student achievement data through assessments, the strategies and reflections utilized to make sense of the data to improve student achievement, ensure curriculum and instructional goals are aligned,…

  1. Theoretical analysis for passage and exit flow of two dimensional centrifugal impeller with leading edge cavitation. Effects of blade number and blade angle

    Energy Technology Data Exchange (ETDEWEB)

    Nishiyama, Hideya

    1988-07-25

    Any analytic study of a centrifugal impeller with a leading edge cavitation is concentrated only on blade or cavity characteristics. Therefore, internal flow condition, especially exit flow, has many indistinctness. Considering that, analysis of flow inside the centrifugal impeller casing and at its exit was performed by the singularity method. In the inside flow of the centrifugal impeller casing, cavitation rear end distortion, cavitation area, relative velocity distribution, pressure inside the cavity, iso-hydrostatic line distribution were examined. In the exit flow, hydrostatic distribution, flow angle distribution, slip velocity distribution, slip constant, blade efficiency, and comparison between obtained and existing slip constant values were examined. As a result, the flow inside the centrifugal impeller in front cavity is found to vary with the number or angle of blades because of the large cavitation area and different from that of no cavitation. The exit flow in the front cavity is different from that at the center of the cavity. The rate of change of slip constant and blade efficiency is large in the front cavity; it is larger when the impeller has fewer blades a lager blade angle. (13 figs, 10 refs)

  2. Why Do Nurses Change Jobs? (An Empirical Test of Determinants of Specific Nurse’s Post-­‐Exit Destinations)

    NARCIS (Netherlands)

    V.M.F. Homburg (Vincent); L. Valkenburg (Lucas)

    2013-01-01

    markdownabstract__Abstract__ Aim The aims of this paper are, first, to identify the determinants of the ‘intention to leave’ of nurses working at a general hospital, and, second, to provide recommendations for various stakeholders targeting prevention of premature leaving to various post-exit desti

  3. "You Can't Hustle All Your Life": An Exploratory Investigation of the Exit Process among Street-Level Prostituted Women

    Science.gov (United States)

    Dalla, Rochelle L.

    2006-01-01

    Between 1998 and 1999, 43 street-level prostituted women were interviewed regarding their developmental experiences, including prostitution entry, maintenance, and exit attempts. Three years later, 18 of the original 43 participants were located and interviewed. This exploratory follow-up investigation focused on the women's life experiences…

  4. Canadian medical tourism companies that have exited the marketplace: Content analysis of websites used to market transnational medical travel

    Directory of Open Access Journals (Sweden)

    Turner Leigh

    2011-10-01

    Full Text Available Abstract Background Medical tourism companies play an important role in promoting transnational medical travel for elective, out-of-pocket medical procedures. Though researchers are paying increasing attention to the global phenomenon of medical tourism, to date websites of medical tourism companies have received limited scrutiny. This article analyzes websites of Canadian medical tourism companies that advertised international healthcare but ultimately exited the marketplace. Using content analysis of company websites as an investigative tool, the article provides a detailed account of medical tourism companies that were based in Canada but no longer send clients to international health care facilities. Methods Internet searches, Google Alerts, searches on Google News Canada and ProQuest Newsstand, and searches of an Industry Canada database were used to locate medical tourism companies located in Canada. Once medical tourism companies were identified, the social science research method of content analysis was used to extract relevant information from company websites. Company websites were analyzed to determine: 1 where these businesses were based; 2 the destination countries and medical facilities that they promoted; 3 the health services they advertised; 4 core marketing messages; and 5 whether businesses marketed air travel, hotel accommodations, and holiday excursions in addition to medical procedures. Results In total, 25 medical tourism companies that were based in Canada are now defunct. Given that an estimated 18 medical tourism companies and 7 regional, cross-border medical travel facilitators now operate in Canada, it appears that approximately half of all identifiable medical tourism companies in Canada are no longer in business. 13 of the previously operational companies were based in Ontario, 7 were located in British Columbia, 4 were situated in Quebec, and 1 was based in Alberta. 14 companies marketed medical procedures within a

  5. Canadian medical tourism companies that have exited the marketplace: Content analysis of websites used to market transnational medical travel

    Science.gov (United States)

    2011-01-01

    Background Medical tourism companies play an important role in promoting transnational medical travel for elective, out-of-pocket medical procedures. Though researchers are paying increasing attention to the global phenomenon of medical tourism, to date websites of medical tourism companies have received limited scrutiny. This article analyzes websites of Canadian medical tourism companies that advertised international healthcare but ultimately exited the marketplace. Using content analysis of company websites as an investigative tool, the article provides a detailed account of medical tourism companies that were based in Canada but no longer send clients to international health care facilities. Methods Internet searches, Google Alerts, searches on Google News Canada and ProQuest Newsstand, and searches of an Industry Canada database were used to locate medical tourism companies located in Canada. Once medical tourism companies were identified, the social science research method of content analysis was used to extract relevant information from company websites. Company websites were analyzed to determine: 1) where these businesses were based; 2) the destination countries and medical facilities that they promoted; 3) the health services they advertised; 4) core marketing messages; and 5) whether businesses marketed air travel, hotel accommodations, and holiday excursions in addition to medical procedures. Results In total, 25 medical tourism companies that were based in Canada are now defunct. Given that an estimated 18 medical tourism companies and 7 regional, cross-border medical travel facilitators now operate in Canada, it appears that approximately half of all identifiable medical tourism companies in Canada are no longer in business. 13 of the previously operational companies were based in Ontario, 7 were located in British Columbia, 4 were situated in Quebec, and 1 was based in Alberta. 14 companies marketed medical procedures within a single country, 9

  6. Building Technologies Program Key Activities

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-15

    The Building Technologies Program (BTP) employs a balanced approach to making buildings more energy efficient. The three pillars of our program, research and development (R&D), market stimulation, and building and equipment standards, help meet our strategic vision.

  7. Green buildings pay

    DEFF Research Database (Denmark)

    Naboni, Emanuele; Edwards, Brian

    2012-01-01

    The new edition of ‘Green Buildings Pay’ authored by Brian Edwards and Emanuele Naboni explores the business and professional benefits which derive from architectural design driven by sustainability. With a new sub-title ‘Green Buildings Pay: design, productivity and ecology’ the book argues...... or environmental thinking and this finds expression in new approaches to the design of building facades, roofs, atria. Another is that new software simulation tools have changed energy assumptions and hence building forms. In a fast evolving arena, the book shows how architects are reshaping their practices....... Branding via LEED and BREEAM has taken green ideas to China and other emerging economies. The globalization of sustainability and of architectural practice is an important strand of the new edition....

  8. Helping clients build credit

    OpenAIRE

    Vikki Frank

    2007-01-01

    Until now people who repaid loans from community groups had not been on credit bureaus’ radar. Now Credit Builders Alliance is partnering with Experian to help clients of community lenders build strong credit histories.

  9. Municipal Building Energy Usage

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This data set contains energy use data from 2009-2014 for 139 municipally operated buildings. Metrics include: Site & Source EUI, annual electricity, natural...

  10. Buildings Sector Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.

    2005-08-01

    A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.

  11. Building Services Systems

    DEFF Research Database (Denmark)

    Zinzi, Michele; Romeo, Carlo; Thomsen, Kirsten Engelund;

    2015-01-01

    of the description of 5 main technologies: condensing boilers, heat pumps, ventilation systems, lighting and photovoltaic systems. For each technology chapter there is the same content list: an introduction, a brief technology description, some advantages and disadvantages, market penetration and utilisation, energy......This guideline on Building Services Systems is one of four guidelines produced by the School of the Future project. The other three guidelines cover: Building Construction Elements, Improved Indoor Environmental Quality and Concepts for Zero Emission Schools. This guideline consists...

  12. Building Peaceful Borders

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    China's efforts to build a harmonious world begin with establishing peaceful borders with its neighbors China's recent contribution to the world of international relations is the promotion of "building a harmonious world together," put forward by President Hu Jintao at the 60th anniversary of the UN in September 2005. As the core of the country's peaceful foreign policy in the new era, this approach has been well received and widely discussed in the international community. Meanwhile, Chinese foreign pol...

  13. Building Materials in Arctic Climate

    DEFF Research Database (Denmark)

    Jensen, Ole Mejlhede

    2005-01-01

    Building in the artic requires special attention on the appropriateness of building materials. The harsh climate makes execution difficult and sets unusual requirements for the pure material properties. In addition, there is a lack of choice of good, natural building materials in the arctic....... This results in high transport costs. The building materials situation in Greenland may potentially be improved by intensifying the reuse of building materials or by promoting the local production of building materials....

  14. Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle

    Directory of Open Access Journals (Sweden)

    Zong-Heng Wang

    2015-07-01

    Full Text Available Drosophila Clueless (Clu and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover a new role for Clu in the delivery of integrin subunits in muscle tissue. In clu mutants, αPS2 integrin, but not βPS integrin, abnormally accumulates in a perinuclear endoplasmic reticulum (ER subdomain, a site that mirrors the endogenous localization of Clu. Loss of components essential for mitochondrial distribution do not phenocopy the clu mutant αPS2 phenotype. Conversely, RNAi knockdown of the Drosophila Golgi reassembly and stacking protein GRASP55/65 (dGRASP recapitulates clu defects, including the abnormal accumulation of αPS2 and larval locomotor activity. Both Clu and dGRASP proteins physically interact and loss of Clu displaces dGRASP from ER exit sites, suggesting that Clu cooperates with dGRASP for the exit of αPS2 from a perinuclear subdomain in the ER. We also found that Clu and dGRASP loss of function leads to ER stress and that the stability of the ER exit site protein Sec16 is severely compromised in the clu mutants, thus explaining the ER accumulation of αPS2. Remarkably, exposure of clu RNAi larvae to chemical chaperones restores both αPS2 delivery and functional ER exit sites. We propose that Clu together with dGRASP prevents ER stress and therefore maintains Sec16 stability essential for the functional organization of perinuclear early secretory pathway. This, in turn, is essential for integrin subunit αPS2 ER exit in Drosophila larval myofibers.

  15. Building Services Requests Subsystem (BSRS)

    Data.gov (United States)

    Department of Transportation — Lotus Notes workflow application used for the submission, processing, tracking and reporting of building service related requiests. Enables regional office building...

  16. Building Better Buildings: Sustainable Building Activities in California Higher Education Systems.

    Science.gov (United States)

    Sowell, Arnold; Eichel, Amanda; Alevantis, Leon; Lovegreen, Maureen

    2003-01-01

    This article outlines the activities and recommendations of California's sustainable building task force, discusses sustainable building activities in California's higher education systems, and highlights key issues that California is grappling with in its implementation of sustainable building practices. (EV)

  17. Diversity Exiting the Academy: Influential Factors for the Career Choice of Well-Represented and Underrepresented Minority Scientists.

    Science.gov (United States)

    Layton, Rebekah L; Brandt, Patrick D; Freeman, Ashalla M; Harrell, Jessica R; Hall, Joshua D; Sinche, Melanie

    2016-01-01

    A national sample of PhD-trained scientists completed training, accepted subsequent employment in academic and nonacademic positions, and were queried about their previous graduate training and current employment. Respondents indicated factors contributing to their employment decision (e.g., working conditions, salary, job security). The data indicate the relative importance of deciding factors influencing career choice, controlling for gender, initial interest in faculty careers, and number of postgraduate publications. Among both well-represented (WR; n = 3444) and underrepresented minority (URM; n = 225) respondents, faculty career choice was positively associated with desire for autonomy and partner opportunity and negatively associated with desire for leadership opportunity. Differences between groups in reasons endorsed included: variety, prestige, salary, family influence, and faculty advisor influence. Furthermore, endorsement of faculty advisor or other mentor influence and family or peer influence were surprisingly rare across groups, suggesting that formal and informal support networks could provide a missed opportunity to provide support for trainees who want to stay in faculty career paths. Reasons requiring alteration of misperceptions (e.g., limited leadership opportunity for faculty) must be distinguished from reasons requiring removal of actual barriers. Further investigation into factors that affect PhDs' career decisions can help elucidate why URM candidates are disproportionately exiting the academy.

  18. Multisite phosphorylation of the Sum1 transcriptional repressor by S-phase kinases controls exit from meiotic prophase in yeast.

    Science.gov (United States)

    Corbi, Daniel; Sunder, Sham; Weinreich, Michael; Skokotas, Aikaterini; Johnson, Erica S; Winter, Edward

    2014-06-01

    Activation of the meiotic transcription factor Ndt80 is a key regulatory transition in the life cycle of Saccharomyces cerevisiae because it triggers exit from pachytene and entry into meiosis. The NDT80 promoter is held inactive by a complex containing the DNA-binding protein Sum1 and the histone deacetylase Hst1. Meiosis-specific phosphorylation of Sum1 by the protein kinases Cdk1, Ime2, and Cdc7 is required for NDT80 expression. Here, we show that the S-phase-promoting cyclin Clb5 activates Cdk1 to phosphorylate most, and perhaps all, of the 11 minimal cyclin-dependent kinase (CDK) phospho-consensus sites (S/T-P) in Sum1. Nine of these sites can individually promote modest levels of meiosis, yet these sites function in a quasiadditive manner to promote substantial levels of meiosis. Two Cdk1 sites and an Ime2 site individually promote high levels of meiosis, likely by preparing Sum1 for phosphorylation by Cdc7. Chromatin immunoprecipitation reveals that the phosphorylation sites are required for removal of Sum1 from the NDT80 promoter. We also find that Sum1, but not its partner protein Hst1, is required to repress NDT80 transcription. Thus, while the phosphorylation of Sum1 may lead to dissociation from DNA by influencing Hst1, it is the presence of Sum1 on DNA that determines whether NDT80 will be expressed.

  19. Multisite Phosphorylation of the Sum1 Transcriptional Repressor by S-Phase Kinases Controls Exit from Meiotic Prophase in Yeast

    Science.gov (United States)

    Corbi, Daniel; Sunder, Sham; Weinreich, Michael; Skokotas, Aikaterini; Johnson, Erica S.

    2014-01-01

    Activation of the meiotic transcription factor Ndt80 is a key regulatory transition in the life cycle of Saccharomyces cerevisiae because it triggers exit from pachytene and entry into meiosis. The NDT80 promoter is held inactive by a complex containing the DNA-binding protein Sum1 and the histone deacetylase Hst1. Meiosis-specific phosphorylation of Sum1 by the protein kinases Cdk1, Ime2, and Cdc7 is required for NDT80 expression. Here, we show that the S-phase-promoting cyclin Clb5 activates Cdk1 to phosphorylate most, and perhaps all, of the 11 minimal cyclin-dependent kinase (CDK) phospho-consensus sites (S/T-P) in Sum1. Nine of these sites can individually promote modest levels of meiosis, yet these sites function in a quasiadditive manner to promote substantial levels of meiosis. Two Cdk1 sites and an Ime2 site individually promote high levels of meiosis, likely by preparing Sum1 for phosphorylation by Cdc7. Chromatin immunoprecipitation reveals that the phosphorylation sites are required for removal of Sum1 from the NDT80 promoter. We also find that Sum1, but not its partner protein Hst1, is required to repress NDT80 transcription. Thus, while the phosphorylation of Sum1 may lead to dissociation from DNA by influencing Hst1, it is the presence of Sum1 on DNA that determines whether NDT80 will be expressed. PMID:24710277

  20. Rapid HIV Screening in an Urban Jail: How Testing at Exit With Linkage to Community Care Can Address Perceived Barriers.

    Science.gov (United States)

    Simonsen, Kari A; Shaikh, Raees A; Earley, Mary; Foxall, Mark; Boyle, Cole; Islam, K M; Younger, Heather; Sandkovsky, Uriel; Berthold, Elizabeth; Margalit, Ruth

    2015-12-01

    Despite recommendations from the CDC, only 36 % of jails offer routine HIV screening to inmates. Our purpose was to explore the feasibility of rapid HIV testing at release from an urban jail, and to identify potential barriers to this process. This project was incorporated into an established partnership between the jail, local academic medical center, and local public health department. We offered rapid HIV testing at the time of release to 507 jail inmates over a 7 week period of 2013. Three hundred and two (60 %) inmates elected testing. All participating inmates received individual test counseling, HIV prevention education, and linkage to care in the community prior to release. All tested inmates received results before release; one inmate screened positive for HIV and was linked to care. Previous HIV testing was the most frequently cited reason given (60 %) among the 205 inmates who declined at the time of the study. Utilizing the partnership between the jail, public health, and an academic medical center, we found that rapid HIV testing at exit was feasible and acceptable in this urban jail setting and could provide immediate linkage to care for those in need.

  1. Satisfaction levels among patients availing DOTS services in Bundelkhand Region (UP, India: Evidence from patient exit-interviews

    Directory of Open Access Journals (Sweden)

    Shalini Srivastav

    2014-01-01

    Full Text Available Context: Patient satisfaction is a determinant of treatment uptake and adherence to Directly Observed Treatment Short course (DOTS therapy for Tuberculosis (TB. Waiting time, staff′s attitude and improvement in symptoms may affect patient′s satisfaction. Aims: The rationale of the present study is to assess the levels of satisfaction among patients utilizing the DOTS services and the factors contributing toward patient satisfaction. Settings and Design: Cross-sectional study. Study Duration: Jan 2009 to March 2009. Study Area: Four Designated Microscopic Centers (DMCs of District Jhansi. Materials and Methods: Exit interviews of all the patients who were diagnosed as TB cases and put on DOTS in the first quarter of 2009 (i.e., subjects registered from 1 st January 2009 to 31 st March 2009 at four selected DMCs were taken on pre-tested questionnaire. Statistical Analysis: Results are expressed in percentages. Results: Average waiting time at center reported was 5-10 minutes by majority of cases (42.7%. Approx.78.6% patients were fully satisfied with the services provided at the centers. Lack of financial burden was the most common reason for satisfaction (95.4%, followed by improvement in symptoms (75%. Most common problems faced by the patients was difficult in coming on alternate days (30.0% followed by loss of wages and transport charges (26.8%. Conclusion: The study findings could potentially be explored to improve DOTS services to attain maximum satisfaction among TB patients.

  2. Trends in Canadian faculties of education: An overview of graduate programs, curricular offerings, exit requirements, and modes of delivery.

    Directory of Open Access Journals (Sweden)

    Carla Abreu Ellis

    2008-07-01

    Full Text Available Introduction This research investigated universities registered with the Association of Universities and Colleges of Canada (AUCC whose primary instructional language was English. A content analysis was performed on university web pages related to the following content: (a frequency of graduate programs being offered, (b types of degrees being offered, (c frequency and variation of program of study offerings, (d variation of exit requirements, and (e modalities of course delivery. This research provides an overview and analysis of graduate level programs, more precisely Masters and Doctorate degrees, offered through faculties of education in Canada. An understanding of the findings of this research may benefit Canadian university administrative bodies in providing a source in which they may compare findings with their current offerings and programming. Prospective students of graduate programs in education may also benefit from the information provided in this study when choosing a program of study by ameliorating their knowledge of current programs, curriculum offerings, and modes of course delivery being offered by faculties of education in Canada.

  3. The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit

    Directory of Open Access Journals (Sweden)

    Pascale Bouchard-Cannon

    2013-11-01

    Full Text Available The subgranular zone (SGZ of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adult SGZ express molecular-clock components and proliferate in a rhythmic fashion. The clock proteins PERIOD2 and BMAL1 are critical for proper control of neurogenesis. The absence of PERIOD2 abolishes the gating of cell-cycle entrance of QNPs, whereas genetic ablation of bmal1 results in constitutively high levels of proliferation and delayed cell-cycle exit. We use mathematical model simulations to show that these observations may arise from clock-driven expression of a cell-cycle inhibitor that targets the cyclin D/Cdk4-6 complex. Our findings may have broad implications for the circadian clock in timing cell-cycle events of other stem cell populations throughout the body.

  4. Diversity Exiting the Academy: Influential Factors for the Career Choice of Well-Represented and Underrepresented Minority Scientists.

    Science.gov (United States)

    Layton, Rebekah L; Brandt, Patrick D; Freeman, Ashalla M; Harrell, Jessica R; Hall, Joshua D; Sinche, Melanie

    2016-01-01

    A national sample of PhD-trained scientists completed training, accepted subsequent employment in academic and nonacademic positions, and were queried about their previous graduate training and current employment. Respondents indicated factors contributing to their employment decision (e.g., working conditions, salary, job security). The data indicate the relative importance of deciding factors influencing career choice, controlling for gender, initial interest in faculty careers, and number of postgraduate publications. Among both well-represented (WR; n = 3444) and underrepresented minority (URM; n = 225) respondents, faculty career choice was positively associated with desire for autonomy and partner opportunity and negatively associated with desire for leadership opportunity. Differences between groups in reasons endorsed included: variety, prestige, salary, family influence, and faculty advisor influence. Furthermore, endorsement of faculty advisor or other mentor influence and family or peer influence were surprisingly rare across groups, suggesting that formal and informal support networks could provide a missed opportunity to provide support for trainees who want to stay in faculty career paths. Reasons requiring alteration of misperceptions (e.g., limited leadership opportunity for faculty) must be distinguished from reasons requiring removal of actual barriers. Further investigation into factors that affect PhDs' career decisions can help elucidate why URM candidates are disproportionately exiting the academy. PMID:27587854

  5. Rapid HIV Screening in an Urban Jail: How Testing at Exit With Linkage to Community Care Can Address Perceived Barriers.

    Science.gov (United States)

    Simonsen, Kari A; Shaikh, Raees A; Earley, Mary; Foxall, Mark; Boyle, Cole; Islam, K M; Younger, Heather; Sandkovsky, Uriel; Berthold, Elizabeth; Margalit, Ruth

    2015-12-01

    Despite recommendations from the CDC, only 36 % of jails offer routine HIV screening to inmates. Our purpose was to explore the feasibility of rapid HIV testing at release from an urban jail, and to identify potential barriers to this process. This project was incorporated into an established partnership between the jail, local academic medical center, and local public health department. We offered rapid HIV testing at the time of release to 507 jail inmates over a 7 week period of 2013. Three hundred and two (60 %) inmates elected testing. All participating inmates received individual test counseling, HIV prevention education, and linkage to care in the community prior to release. All tested inmates received results before release; one inmate screened positive for HIV and was linked to care. Previous HIV testing was the most frequently cited reason given (60 %) among the 205 inmates who declined at the time of the study. Utilizing the partnership between the jail, public health, and an academic medical center, we found that rapid HIV testing at exit was feasible and acceptable in this urban jail setting and could provide immediate linkage to care for those in need. PMID:26510745

  6. Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection.

    Directory of Open Access Journals (Sweden)

    Andreea Popa

    2015-02-01

    Full Text Available Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or the plasma membrane. Here we show that the HPV16 L2 minor capsid protein is a retromer cargo, even though L2 is not a transmembrane protein. We show that direct binding of retromer to a conserved sequence in the carboxy-terminus of L2 is required for exit of L2 from the early endosome and delivery to the trans-Golgi network during virus entry. This binding site is different from known retromer binding motifs and can be replaced by a sorting signal from a cellular retromer cargo. Thus, HPV16 is an unconventional particulate retromer cargo, and retromer binding initiates retrograde transport of viral components from the endosome to the trans-Golgi network during virus entry. We propose that the carboxy-terminal segment of L2 protein protrudes through the endosomal membrane and is accessed by retromer in the cytoplasm.

  7. A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo.

    Directory of Open Access Journals (Sweden)

    Jordi Colonques

    Full Text Available Cell proliferation, specification and terminal differentiation must be precisely coordinated during brain development to ensure the correct production of different neuronal populations. Most Drosophila neuroblasts (NBs divide asymmetrically to generate a new NB and an intermediate progenitor called ganglion mother cell (GMC which divides only once to generate two postmitotic cells called ganglion cells (GCs that subsequently differentiate into neurons. During the asymmetric division of NBs, the homeodomain transcription factor PROSPERO is segregated into the GMC where it plays a key role as cell fate determinant. Previous work on embryonic neurogenesis has shown that PROSPERO is not expressed in postmitotic neuronal progeny. Thus, PROSPERO is thought to function in the GMC by repressing genes required for cell-cycle progression and activating genes involved in terminal differentiation. Here we focus on postembryonic neurogenesis and show that the expression of PROSPERO is transiently upregulated in the newly born neuronal progeny generated by most of the larval NBs of the OL and CB. Moreover, we provide evidence that this expression of PROSPERO in GCs inhibits their cell cycle progression by activating the expression of the cyclin-dependent kinase inhibitor (CKI DACAPO. These findings imply that PROSPERO, in addition to its known role as cell fate determinant in GMCs, provides a transient signal to ensure a precise timing for cell cycle exit of prospective neurons, and hence may link the mechanisms that regulate neurogenesis and those that control cell cycle progression in postembryonic brain development.

  8. The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit.

    Science.gov (United States)

    Bouchard-Cannon, Pascale; Mendoza-Viveros, Lucia; Yuen, Andrew; Kærn, Mads; Cheng, Hai-Ying M

    2013-11-27

    The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adult SGZ express molecular-clock components and proliferate in a rhythmic fashion. The clock proteins PERIOD2 and BMAL1 are critical for proper control of neurogenesis. The absence of PERIOD2 abolishes the gating of cell-cycle entrance of QNPs, whereas genetic ablation of bmal1 results in constitutively high levels of proliferation and delayed cell-cycle exit. We use mathematical model simulations to show that these observations may arise from clock-driven expression of a cell-cycle inhibitor that targets the cyclin D/Cdk4-6 complex. Our findings may have broad implications for the circadian clock in timing cell-cycle events of other stem cell populations throughout the body.

  9. Problems and Strategies of Teachers' Exit Mechanism%中小学教师退出机制的问题审视与对策建议

    Institute of Scientific and Technical Information of China (English)

    王天平; 高艳霞

    2016-01-01

    Teachers' exit mechanism is a set of system design that can optimize the structure of teach‐ers ,promote teachers' professional skill and development .It plays an important role in the quality of teachers and education .In China ,the primary and secondary school teachers' exit mechanism is still in the preliminary stage ,w hose essential feature is that operation mechanism discriminating incompetent teachers ,dynamic mechanism driving by policy , and restriction mechanism implementing teacher management according to law .But there are some problems such as anomie of operating mechanism , lack of dynamic mechanism ,hiatus of restriction mechanism in relevant policy‐making and practical exploration .The incorporation are that exit criteria is undefined ,exit program is non‐standard ,the way of exit is inappropriate ,exit mechanism is imperfect ,and exit is not ensured .So it's necessary to optimize the evaluation system ,standardize the exit program ,amplify the re‐employment training system ,create an atmosphere of teachers' exit ,improve social security system ,perfect supervisory mechanism ,and intensify social restriction mechanism ,by means of “survival of the fittest”and“cure the sickness to save the patient” to optimize the primary and secondary teachers team .%完善教师退出机制可以优化教师队伍结构、提升教师业务水平、促进教师专业发展,有利于提升教师队伍的素质。我国中小学教师退出机制处于初步探索阶段,表现出运行机制着眼甄别不胜任教师、动力机制主要源于政策驱动、约束机制重在依法实施教师管理等基本特征,同时在相应的政策制定和实践探索方面存在运行机制失范、动力机制缺乏、约束机制缺失等问题,具体表现为退出标准不明确、退出程序不规范、退出方式简单化、退出制度不健全、退出保障不到位。因此,应优化教师考评机制,规范教师退出程序,健

  10. Development of two Danish building typologies for residential buildings

    DEFF Research Database (Denmark)

    Kragh, Jesper; Wittchen, Kim Bjarne

    2014-01-01

    performance of the residential building stock. Overall, the typologies consist of two types of building models—real example models and average designed models. The main purpose of developing the building typologies was to establish a tool able to calculate different energy-saving scenarios for the entire...... residential building stock. To make such calculations of scenarios, similar average designed building models were established based on extracted average values from the Danish Energy Performance Certification Scheme database. The two building typologies had the same overall composition, i.e., three main...... building types: single-family houses, terraced houses and blocks of flats. Each main building type is presented for nine periods representing age, typical building tradition and insulation levels. Finally, an energy balance model of the residential building stock was devised to validate the average...

  11. SOLAR EFFECTS ON BUILDING DESIGN.

    Science.gov (United States)

    Building Research Inst., Inc., Washington, DC.

    A REPORT OF A PROGRAM HELD AS PART OF THE BUILDING RESEARCH INSTITUTE 1962 SPRING CONFERENCE ON THE SOLAR EFFECTS ON BUILDING DESIGN. TOPICS DISCUSSED ARE--(1) SOLAR ENERGY DATA APPLICABLE TO BUILDING DESIGN, (2) THERMAL EFFECTS OF SOLAR RADIATION ON MAN, (3) SOLAR EFFECTS ON ARCHITECTURE, (4) SOLAR EFFECTS ON BUILDING COSTS, (5) SELECTION OF…

  12. Buildings for advanced technology

    CERN Document Server

    Teague, E; Murday, James

    2015-01-01

    This book deals with the design and construction of buildings for nanoscale science and engineering research. The information provided in this book is useful for designing and constructing buildings for such advanced technologies as nanotechnology, nanoelectronics and biotechnology. The book outlines the technology challenges unique to each of the building environmental challenges outlined below and provides best practices and examples of engineering approaches to address them: • Establishing and maintaining critical environments: temperature, humidity, and pressure • Structural vibration isolation • Airborne vibration isolation (acoustic noise) • Isolation of mechanical equipment-generated vibration/acoustic noise • Cost-effective power conditioning • Grounding facilities for low electrical interference • Electromagnetic interference (EMI)/Radio frequency interference (RFI) isolation • Airborne particulate contamination • Airborne organic and chemical contamination • Environment, safety a...

  13. On building Information Warehouses

    CERN Document Server

    Laha, Arijit

    2009-01-01

    One of the most important goals of information management (IM) is supporting the knowledge workers in performing their works. In this paper we examine issues of relevance, linkage and provenance of information, as accessed and used by the knowledge workers. These are usually not adequately addressed in most of the IT based solutions for IM. Here we propose a non-conventional approach for building information systems for supporting the knowledge workers which addresses these issues. The approach leads to the ideas of building Information Warehouses (IW) and Knowledge work Support Systems (KwSS). Such systems can open up potential for building innovative applications of significant impact, including those capable of helping organizations in implementing processes for double-loop learning.

  14. Automated model building

    CERN Document Server

    Caferra, Ricardo; Peltier, Nicholas

    2004-01-01

    This is the first book on automated model building, a discipline of automated deduction that is of growing importance Although models and their construction are important per se, automated model building has appeared as a natural enrichment of automated deduction, especially in the attempt to capture the human way of reasoning The book provides an historical overview of the field of automated deduction, and presents the foundations of different existing approaches to model construction, in particular those developed by the authors Finite and infinite model building techniques are presented The main emphasis is on calculi-based methods, and relevant practical results are provided The book is of interest to researchers and graduate students in computer science, computational logic and artificial intelligence It can also be used as a textbook in advanced undergraduate courses

  15. Building information deduced

    DEFF Research Database (Denmark)

    Tamke, Martin; Myrup Jensen, Morten; Beetz, Jakob;

    2014-01-01

    In recent years, Building Information Models have become commonplace in building profession. The extensive use and increasing experience with BIM models offers new perspectives and potentials for design and planning. A recent stakeholder study conducted by the authors of this paper show...... of a model, differences in separate models or models from different point of time. Current BIM tools support both modes only in a rudimentary form. This paper discusses current modes of information query within and across BIM models, shows beneficial scenarios for building and planning practice through...... that in practice models are no longer solely observed as culmination of knowledge in a 3d representation of future built structures, but as a source of information in itself. Experienced users of BIM want to Find Information within a model or across a set of these and Compare models in order to evaluate states...

  16. Zero Energy Building

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Heiselberg, Per; Bourrelle, J.S.;

    2011-01-01

    , (4) the type of energy balance, (5) the accepted renewable energy supply options, (6) the connection to the energy infrastructure and (7) the requirements for the energy efficiency, the indoor climate and in case of gird connected ZEB for the building–grid interaction. This paper focuses......The concept of Zero Energy Building (ZEB) has gained wide international attention during last few years and is now seen as the future target for the design of buildings. However, before being fully implemented in the national building codes and international standards, the ZEB concept requires...... clear and consistent definition and a commonly agreed energy calculation methodology. The most important issues that should be given special attention before developing a new ZEB definition are: (1) the metric of the balance, (2) the balancing period, (3) the type of energy use included in the balance...

  17. Carbon Efficient Building Solutions

    Directory of Open Access Journals (Sweden)

    Pellervo Matilainen

    2010-03-01

    Full Text Available Traditionally, the Finnish legislation have focused on energy use and especially on energy used for heating space in buildings. However, in many cases this does not lead to the optimal concept in respect to minimizing green house gases. This paper studies how CO2 emission levels are affected by different measures to reduce energy use in buildings. This paper presents two real apartment buildings with different options of energy efficiency and power sources. The calculations clearly show that in the future electricity and domestic hot water use will have high importance in respect to energy efficiency, and therefore also CO2 equivalent (eq emissions. The importance increases when the energy efficiency of the building increases. There are big differences between average Finnish production and individual power plants; CO2 eq emissions might nearly double depending on the energy source and the power plant type. Both a building with an efficient district heating as a power source, and a building with ground heat in addition to nuclear power electricity as a complimentary electricity source performed very similarly to each other in respect to CO2 eq emissions. However, it is dangerous to conclude that it is not important which energy source is chosen. If hypothetically, the use of district heating would dramatically drop, the primary energy factor and CO2 eq emissions from electricity would rise, which in turn would lead to the increase of the ground heat systems emissions. A problem in the yearly calculations is that the fact that it is very important, sometimes even crucial, when energy is needed, is always excluded.

  18. Climate Responsive Buildings in China

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; Heiselberg, Per

    2006-01-01

    There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...... of responsive building elements, of integrated building concepts and of environmental performance assessment methods to improve and optimize responsive building elements to develop and optimize new building concepts with integration of responsive building elements, HVAC-systems as well as natural and renewable...... energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work within the framework of the Annex44 of the International Energy Agency (IEA...

  19. The exited hexagon reloaded

    Energy Technology Data Exchange (ETDEWEB)

    Bartels, Joachim [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Kotanski, Jan; Schomerus, Volker; Sprenger, Martin [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-11-15

    This work revisits the computation of six-gluon scattering amplitudes in the high energy limit of strongly coupled N=4 supersymmetric Yang-Mills theory. It is based on previous studies in which we showed that the amplitude simplifies in the Regge regime and outlined an efficient computational scheme. By exploiting a symmetry of the underlying equations we are now able to argue that a term we had seen in preliminary numerical studies must vanish identically. The derived formula for the Regge limit of the 6-gluon scattering amplitude at strong coupling differs from the one we had conjectured previously.

  20. Between exit and voice

    DEFF Research Database (Denmark)

    Meret, Susi; Della Corte, Elisabetta

    2014-01-01

    European politics currently serves to reinforce the ‘Fortress’, leaving refugees vulnerable and futureless, battling a system which is waging war against them. But 'Lampedusa in Hamburg' demonstrates that civil society can work effectively with migrants for their rights to a safe existence....