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Sample records for building disease-specific drug-protein

  1. Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts.

    Directory of Open Access Journals (Sweden)

    Jiao Li

    2009-07-01

    Full Text Available The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions. The study of these maps provides opportunities for future toxicogenomics and drug discovery applications. We developed a computational framework to build disease-specific drug-protein connectivity maps. We integrated gene/protein and drug connectivity information based on protein interaction networks and literature mining, without requiring gene expression profile information derived from drug perturbation experiments on disease samples. We described the development and application of this computational framework using Alzheimer's Disease (AD as a primary example in three steps. First, molecular interaction networks were incorporated to reduce bias and improve relevance of AD seed proteins. Second, PubMed abstracts were used to retrieve enriched drug terms that are indirectly associated with AD through molecular mechanistic studies. Third and lastly, a comprehensive AD connectivity map was created by relating enriched drugs and related proteins in literature. We showed that this molecular connectivity map development approach outperformed both curated drug target databases and conventional information retrieval systems. Our initial explorations of the AD connectivity map yielded a new hypothesis that diltiazem and quinidine may be investigated as candidate drugs for AD treatment. Molecular connectivity maps derived computationally can help study molecular signature differences between different classes of drugs in specific disease contexts. To achieve overall good data coverage and quality, a series of statistical methods have been developed to overcome high levels of data noise in biological networks and literature mining results. Further development of computational molecular connectivity maps to cover major disease areas will likely set

  2. Disease specific protein corona

    Science.gov (United States)

    Rahman, M.; Mahmoudi, M.

    2015-03-01

    It is now well accepted that upon their entrance into the biological environments, the surface of nanomaterials would be covered by various biomacromolecules (e.g., proteins and lipids). The absorption of these biomolecules, so called `protein corona', onto the surface of (nano)biomaterials confers them a new `biological identity'. Although the formation of protein coronas on the surface of nanoparticles has been widely investigated, there are few reports on the effect of various diseases on the biological identity of nanoparticles. As the type of diseases may tremendously changes the composition of the protein source (e.g., human plasma/serum), one can expect that amount and composition of associated proteins in the corona composition may be varied, in disease type manner. Here, we show that corona coated silica and polystyrene nanoparticles (after interaction with in the plasma of the healthy individuals) could induce unfolding of fibrinogen, which promotes release of the inflammatory cytokines. However, no considerable releases of inflammatory cytokines were observed for corona coated graphene sheets. In contrast, the obtained corona coated silica and polystyrene nanoparticles from the hypofibrinogenemia patients could not induce inflammatory cytokine release where graphene sheets do. Therefore, one can expect that disease-specific protein coronas can provide a novel approach for applying nanomedicine to personalized medicine, improving diagnosis and treatment of different diseases tailored to the specific conditions and circumstances.

  3. Disease specific productivity of american cancer hospitals.

    Directory of Open Access Journals (Sweden)

    Jeffery A Goldstein

    Full Text Available Research-oriented cancer hospitals in the United States treat and study patients with a range of diseases. Measures of disease specific research productivity, and comparison to overall productivity, are currently lacking.Different institutions are specialized in research of particular diseases.To report disease specific productivity of American cancer hospitals, and propose a summary measure.We conducted a retrospective observational survey of the 50 highest ranked cancer hospitals in the 2013 US News and World Report rankings. We performed an automated search of PubMed and Clinicaltrials.gov for published reports and registrations of clinical trials (respectively addressing specific cancers between 2008 and 2013. We calculated the summed impact factor for the publications. We generated a summary measure of productivity based on the number of Phase II clinical trials registered and the impact factor of Phase II clinical trials published for each institution and disease pair. We generated rankings based on this summary measure.We identified 6076 registered trials and 6516 published trials with a combined impact factor of 44280.4, involving 32 different diseases over the 50 institutions. Using a summary measure based on registered and published clinical trails, we ranked institutions in specific diseases. As expected, different institutions were highly ranked in disease-specific productivity for different diseases. 43 institutions appeared in the top 10 ranks for at least 1 disease (vs 10 in the overall list, while 6 different institutions were ranked number 1 in at least 1 disease (vs 1 in the overall list.Research productivity varies considerably among the sample. Overall cancer productivity conceals great variation between diseases. Disease specific rankings identify sites of high academic productivity, which may be of interest to physicians, patients and researchers.

  4. Building

    OpenAIRE

    Seavy, Ryan

    2014-01-01

    Building for concrete is temporary. The building of wood and steel stands against the concrete to give form and then gives way, leaving a trace of its existence behind. Concrete is not a building material. One does not build with concrete. One builds for concrete. MARCH

  5. Network Analysis Identifies Disease-Specific Pathways for Parkinson's Disease.

    Science.gov (United States)

    Monti, Chiara; Colugnat, Ilaria; Lopiano, Leonardo; Chiò, Adriano; Alberio, Tiziana

    2018-01-01

    Neurodegenerative diseases are characterized by the progressive loss of specific neurons in selected regions of the central nervous system. The main clinical manifestation (movement disorders, cognitive impairment, and/or psychiatric disturbances) depends on the neuron population being primarily affected. Parkinson's disease is a common movement disorder, whose etiology remains mostly unknown. Progressive loss of dopaminergic neurons in the substantia nigra causes an impairment of the motor control. Some of the pathogenetic mechanisms causing the progressive deterioration of these neurons are not specific for Parkinson's disease but are shared by other neurodegenerative diseases, like Alzheimer's disease and amyotrophic lateral sclerosis. Here, we performed a meta-analysis of the literature of all the quantitative proteomic investigations of neuronal alterations in different models of Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis to distinguish between general and Parkinson's disease-specific pattern of neurodegeneration. Then, we merged proteomics data with genetics information from the DisGeNET database. The comparison of gene and protein information allowed us to identify 25 proteins involved uniquely in Parkinson's disease and we verified the alteration of one of them, i.e., transaldolase 1 (TALDO1), in the substantia nigra of 5 patients. By using open-source bioinformatics tools, we identified the biological processes specifically affected in Parkinson's disease, i.e., proteolysis, mitochondrion organization, and mitophagy. Eventually, we highlighted four cellular component complexes mostly involved in the pathogenesis: the proteasome complex, the protein phosphatase 2A, the chaperonins CCT complex, and the complex III of the respiratory chain.

  6. Sector-wide or disease-specific? Implications of trends in development assistance for health for the SDG era.

    Science.gov (United States)

    Buffardi, Anne L

    2018-01-16

    The record of the Millennium Development Goals broadly reflects the trade-offs of disease-specific financing: substantial progress in particular areas, facilitated by time-bound targets that are easy to measure and communicate, which shifted attention and resources away from other areas, masked inequalities and exacerbated fragmentation. In many ways, the Sustainable Development Goals reflect a profound shift towards a more holistic, system-wide approach. To inform responses to this shift, this article builds upon existing work on aggregate trends in donor financing, bringing together what have largely been disparate analyses of sector-wide and disease-specific financing approaches. Looking across the last 26 years, the article examines how international donors have allocated development assistance for health (DAH) between these two approaches and how attempts to bridge them have fared in practice. Since 1990, DAH has overwhelmingly favoured disease-specific earmarks over health sector support, with the latter peaking in 1998. Attempts to integrate system strengthening elements into disease-specific funding mechanisms have varied by disease, and more integrated funding platforms have failed to gain traction. Health sector support largely remains an unfulfilled promise: proportionately low amounts (albeit absolute increases) which have been inconsistently allocated, and the overall approach inconsistently applied in practice. Thus, the expansive orientation of the Sustainable Development Goals runs counter to trends over the last several decades. Financing proposals and efforts to adapt global health institutions must acknowledge and account for the persistent challenges in the financing and implementation of integrated, cross-sector policies. National and subnational experimentation may offer alternatives within and beyond the health sector. © The Author(s) 2018. Published by Oxford University Press in association with The London School of Hygiene and Tropical

  7. Gender disparities in disease-specific health status in postoperative patients with peripheral arterial disease

    DEFF Research Database (Denmark)

    Mastenbroek, M H; Hoeks, S E; Pedersen, Susanne S.

    2012-01-01

    To investigate gender disparities in disease-specific health status (HS), 3- and 5-year post-intervention in peripheral arterial disease (PAD) patients.......To investigate gender disparities in disease-specific health status (HS), 3- and 5-year post-intervention in peripheral arterial disease (PAD) patients....

  8. Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks.

    Science.gov (United States)

    Liu, Hui; Guo, Mengmeng; Xue, Ting; Guan, Jihong; Luo, Libo; Zhuang, Ziheng

    2016-12-23

    One of the most challenging tasks in the exploration of anti-aging is to discover drugs that can promote longevity and delay the incidence of age-associated diseases of human. Up to date, a number of drugs, including some antioxidants, metabolites and synthetic compounds, have been found to effectively delay the aging of nematodes and insects. We proposed a label propagation algorithm on drug-protein network to infer drugs that can extend the lifespan of C. elegans. We collected a set of drugs of which functions on lifespan extension of C. elegans have been reliably determined, and then built a large-scale drug-protein network by collecting a set of high-confidence drugprotein interactions. A label propagation algorithm was run on the drug-protein bipartite network to predict new drugs with lifespan-extending effect on C. elegans. We calibrated the performance of the proposed method by conducting performance comparison with two classical models, kNN and SVM. We also showed that the screened drugs significantly mediate in the aging-related pathways, and have higher chemical similarities to the effective drugs than ineffective drugs in promoting longevity of C. elegans. Moreover, we carried out wet-lab experiments to verify a screened drugs, 2- Bromo-4'-nitroacetophenone, and found that it can effectively extend the lifespan of C. elegans. These results showed that our method is effective in screening lifespanextending drugs in C. elegans. In this paper, we proposed a semi-supervised algorithm to predict drugs with lifespan-extending effects on C. elegans. In silico empirical evaluations and in vivo experiments in C. elegans have demonstrated that our method can effectively narrow down the scope of candidate drugs needed to be verified by wet lab experiments.

  9. Determination of hepatic clearance with the account of drug-protein binding kinetics.

    Science.gov (United States)

    Berezhkovskiy, Leonid M

    2012-10-01

    Binding of drugs to plasma proteins is commonly considered in pharmacokinetics as being in an instantaneous equilibrium. Although if the timescale of dissociation of drug-protein complex becomes comparable to the time that a drug molecule spends in blood while passing through the elimination organ, the kinetics of protein binding may influence the organ clearance. This appears possible for the compounds that have large dissociation energy from protein. Typically, the dissociation of drug-protein complex is fast. However, the longest experimentally observed average bound time of drug to human albumin was as much as 11 min, whereas the time that a drug molecule spends in blood while passing through the liver is around 19 s. The equations for the calculation of hepatic clearance (Cl(h)) with the account of protein binding kinetics are derived for the well-stirred and parallel-tube models. It turns out that for drugs with very low extraction ratio, the influence of protein binding kinetics on Cl(h) is negligible; however, for drugs with high extraction ratio, it may lead to substantially smaller values (possibly by an order of magnitude) of Cl(h) compared with that provided by the common calculations. Copyright © 2012 Wiley Periodicals, Inc.

  10. High-Performance Affinity Chromatography: Applications in Drug-Protein Binding Studies and Personalized Medicine.

    Science.gov (United States)

    Li, Zhao; Beeram, Sandya R; Bi, Cong; Suresh, D; Zheng, Xiwei; Hage, David S

    2016-01-01

    The binding of drugs with proteins and other agents in serum is of interest in personalized medicine because this process can affect the dosage and action of drugs. The extent of this binding may also vary with a given disease state. These interactions may involve serum proteins, such as human serum albumin or α1-acid glycoprotein, or other agents, such as lipoproteins. High-performance affinity chromatography (HPAC) is a tool that has received increasing interest as a means for studying these interactions. This review discusses the general principles of HPAC and the various approaches that have been used in this technique to examine drug-protein binding and in work related to personalized medicine. These approaches include frontal analysis and zonal elution, as well as peak decay analysis, ultrafast affinity extraction, and chromatographic immunoassays. The operation of each method is described and examples of applications for these techniques are provided. The type of information that can be obtained by these methods is also discussed, as related to the analysis of drug-protein binding and the study of clinical or pharmaceutical samples. © 2016 Elsevier Inc. All rights reserved.

  11. Plasma YKL-40 and total and disease-specific mortality in the general population

    DEFF Research Database (Denmark)

    Johansen, Julia S; Bojesen, Stig E; Tybjaerg-Hansen, Anne

    2010-01-01

    Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population....

  12. Development of disease-specific quality indicators for danish chiropractic patients with low back pain

    DEFF Research Database (Denmark)

    Sorensen, Line P; Krog, Birgitte R; Kongsted, Alice

    2011-01-01

    The purpose of this study is to develop disease-specific quality indicators for Danish chiropractic patients with low back pain (LBP) as an initial effort to include chiropractors in the Danish Health Care Quality Programme.......The purpose of this study is to develop disease-specific quality indicators for Danish chiropractic patients with low back pain (LBP) as an initial effort to include chiropractors in the Danish Health Care Quality Programme....

  13. Disease-specific direct-to-consumer advertising for reminding consumers to take medications.

    Science.gov (United States)

    Bhutada, Nilesh S; Rollins, Brent L

    2015-01-01

    To assess the relationship between disease-specific direct-to-consumer (DTC) advertising, via traditional advertising effectiveness measures, and consumers' self-reported medication-taking behavior. Data were gathered for 514 respondents (age 18 and above) using an online survey panel. Participants were exposed to a disease-specific (i.e., nonbranded) DTC advertising for depression. The advertising stimulus created for the study was based on the Food and Drug Administration guidelines for disease-specific DTC advertising and modeled after current print disease-specific DTC advertising. Participants reviewed the advertising stimulus through the online program and then responded to a questionnaire containing closed-ended questions assessing the constructs. Data were analyzed using chi-square tests. All tests were interpreted at an a priori alpha of 0.05. Significantly more respondents who were highly involved, paid more attention to the advertisement, and were responsive to DTC advertisements in the past indicated that the disease-specific DTC advertising stimulus reminded them to take their depression and other medications. These exploratory results show disease-specific DTC advertising can help people remember to take their prescription medication when viewed, which may lead to more positive medication-taking behavior and increased medication adherence. Additionally, given the fair balance and legal issues surrounding product-specific DTC advertising, disease-specific DTC advertising can serve as an effective component of the marketing mix for pharmaceutical manufacturers. Future research should attempt to study the impact of disease-specific DTC advertising on consumers' actual medication adherence using standardized adherence measures such as prescription records.

  14. Plasma YKL-40 and total and disease-specific mortality in the general population

    DEFF Research Database (Denmark)

    Johansen, Julia S; Bojesen, Stig E; Tybjaerg-Hansen, Anne

    2010-01-01

    Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population.......Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population....

  15. Generic and disease-specific measures of quality of life in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Bhattacharya, Sumangala; Vogel, A.; Hansen, M.L.

    2010-01-01

    The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD).......The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD)....

  16. Using classification models for the generation of disease-specific medications from biomedical literature and clinical data repository.

    Science.gov (United States)

    Wang, Liqin; Haug, Peter J; Del Fiol, Guilherme

    2017-05-01

    Mining disease-specific associations from existing knowledge resources can be useful for building disease-specific ontologies and supporting knowledge-based applications. Many association mining techniques have been exploited. However, the challenge remains when those extracted associations contained much noise. It is unreliable to determine the relevance of the association by simply setting up arbitrary cut-off points on multiple scores of relevance; and it would be expensive to ask human experts to manually review a large number of associations. We propose that machine-learning-based classification can be used to separate the signal from the noise, and to provide a feasible approach to create and maintain disease-specific vocabularies. We initially focused on disease-medication associations for the purpose of simplicity. For a disease of interest, we extracted potentially treatment-related drug concepts from biomedical literature citations and from a local clinical data repository. Each concept was associated with multiple measures of relevance (i.e., features) such as frequency of occurrence. For the machine purpose of learning, we formed nine datasets for three diseases with each disease having two single-source datasets and one from the combination of previous two datasets. All the datasets were labeled using existing reference standards. Thereafter, we conducted two experiments: (1) to test if adding features from the clinical data repository would improve the performance of classification achieved using features from the biomedical literature only, and (2) to determine if classifier(s) trained with known medication-disease data sets would be generalizable to new disease(s). Simple logistic regression and LogitBoost were two classifiers identified as the preferred models separately for the biomedical-literature datasets and combined datasets. The performance of the classification using combined features provided significant improvement beyond that using

  17. Disease-specific health status as a predictor of mortality in patients with heart failure

    DEFF Research Database (Denmark)

    Mastenbroek, Mirjam H; Versteeg, Henneke; Zijlstra, Wobbe P

    2014-01-01

    . Searching PubMed (until March 2013) resulted in 17 articles in the systematic review and 17 studies in the meta-analysis. About half of the studies reported a significant relationship between disease-specific health status and mortality in heart failure, while the remainder found no association. A larger...

  18. Profile of Generic and Disease-Specific Health-Related Quality of ...

    African Journals Online (AJOL)

    TNHJOURNALPH

    Parkinson's disease causes significant disability and impairs health-related quality of life. However, this dimension has not been fully characterised, particularly among Africans. We examined the generic and disease- specific health related quality of life profiles of Nigerian Africans with. Parkinson's disease in comparison to.

  19. Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis

    NARCIS (Netherlands)

    Yeremenko, Nataliya; Noordenbos, Troy; Cantaert, Tineke; van Tok, Melissa; van de Sande, Marleen; Cañete, Juan D.; Tak, Paul P.; Baeten, Dominique

    2013-01-01

    The molecular processes driving the distinct patterns of synovial inflammation and tissue remodeling in spondylarthritis (SpA) as compared to rheumatoid arthritis (RA) remain largely unknown. Therefore, we aimed to identify novel and unsuspected disease-specific pathways in SpA by a systematic and

  20. Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21

    Science.gov (United States)

    2014-01-01

    Background Non-invasive prenatal testing of trisomy 21 (T21) is being actively investigated using fetal-specific epigenetic markers (EPs) that are present in maternal plasma. Recently, 12 EPs on chromosome 21 were identified based on tissue-specific epigenetic characteristics between placenta and blood, and demonstrated excellent clinical performance in the non-invasive detection of fetal T21. However, the disease-specific epigenetic characteristics of the EPs have not been established. Therefore, we validated the disease-specific epigenetic characteristics of these EPs for use in non-invasive detection of fetal T21. Methods We performed a high-resolution tiling array analysis of human chromosome 21 using a methyl-CpG binding domain-based protein (MBD) method with whole blood samples from non-pregnant normal women, whole blood samples from pregnant normal women, placenta samples of normal fetuses, and placenta samples of T21 fetuses. Tiling array results were validated by bisulfite direct sequencing and qPCR. Results Among 12 EPs, only four EPs were confirmed to be hypermethylated in normal placenta and hypomethylated in blood. One of these four showed a severe discrepancy in the methylation patterns of T21 placenta samples, and another was located within a region of copy number variations. Thus, two EPs were confirmed to be potential fetal-specific markers based on their disease-specific epigenetic characteristics. The array results of these EPs were consisted with the results obtained by bisulfite direct sequencing and qPCR. Moreover, the two EPs were detected in maternal plasma. Conclusions We validated that two EPs have the potential to be fetal-specific EPs which is consistent with their disease-specific epigenetic characteristics. The findings of this study suggest that disease-specific epigenetic characteristics should be considered in the development of fetal-specific EPs for non-invasive prenatal testing of T21. PMID:24397966

  1. Detection of heterogeneous drug-protein binding by frontal analysis and high-performance affinity chromatography.

    Science.gov (United States)

    Tong, Zenghan; Joseph, K S; Hage, David S

    2011-12-09

    This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this model system and chromatographic theory that double-reciprocal plots could be used more easily than traditional isotherms for the initial detection of binding site heterogeneity. The deviations from linearity that were seen in double-reciprocal plots as a result of heterogeneity were a function of the analyte concentration, the relative affinities of the binding sites in the system and the amount of each type of site that was present. The size of these deviations was determined and compared under various conditions. Plots were also generated to show what experimental conditions would be needed to observe these deviations for general heterogeneous systems or for cases in which some preliminary information was available on the extent of binding heterogeneity. The methods developed in this work for the detection of binding heterogeneity are not limited to drug interactions with HSA but could be applied to other types of drug-protein binding or to additional biological systems with heterogeneous binding. Copyright © 2011 Elsevier B.V. All rights reserved.

  2. Generic and disease-specific measures of quality of life in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Bhattacharya, Suvosree; Vogel, Asmus; Hansen, Marie-Louise H

    2010-01-01

    BACKGROUND/AIM: The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD). METHODS: The participants were 321 home-living patients with mild AD...... and their primary caregivers from the Danish Alzheimer Intervention Study. QoL was assessed using the generic EuroQol-5D with visual analogue scale (VAS) and the disease-specific Quality of Life in Alzheimer's Disease (QOL-AD) scales (both caregiver and patient rated). Depression, activities of daily living......, cognitive performance and neuropsychiatric symptom severity were also assessed. RESULTS: All 3 caregiver-rated QoL scales correlated significantly with each other (p Patient-rated QoL versions correlated inversely with depression (p

  3. Patient- and Disease-Specific Factors Associated With Operative Management of de Quervain Tendinopathy.

    Science.gov (United States)

    Kazmers, Nikolas H; Liu, Tiffany C; Gordon, Joshua A; Bozentka, David J; Steinberg, David R; Gray, Benjamin L

    2017-09-07

    It remains unclear which factors, patient- or disease-specific, are associated with electing to undergo operative management for de Quervain tendinopathy. Our null hypothesis was that no patient- or disease-specific factors would be associated with the choice of surgical treatment of de Quervain tendinopathy. We performed a retrospective review of consecutive patients diagnosed with de Quervain tendinopathy over 3 years by 1 of 3 fellowship-trained hand surgeons at an urban academic institution. Descriptive statistics were calculated for patient baseline and disease-specific characteristics. Cohorts were compared using bivariate analysis for all collected variables. Binary logistic regression with backward stepwise term selection was performed including independent predictors identified by bivariate analysis. A total of 200 patients were identified for inclusion. Bivariate analysis revealed that surgically treated patients were significantly more likely to have Medicaid insurance, psychiatric illness history, and disabled work status. Regression analysis revealed an association between surgical treatment and 2 of the factors evaluated: Medicaid insurance status and psychiatric illness history. Psychiatric illness and Medicaid insurance status are associated with undergoing surgical release of the first dorsal compartment. These findings support the use of a biopsychosocial framework when treating patients with de Quervain tendinopathy. Prognostic IV. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  4. Disease-specific Growth Charts of Marfan Syndrome Patients in Korea.

    Science.gov (United States)

    Kwun, Younghee; Kim, Su Jin; Lee, Jieun; Isojima, Tsuyoshi; Choi, Doo-Seok; Kim, Duk-Kyung; Huh, June; Kang, I-Seok; Chang, MiSun; Cho, Sung Yoon; Sohn, Young Bae; Park, Sung Won; Jin, Dong-Kyu

    2015-07-01

    Patients with Marfan syndrome (MFS) presents with primary skeletal manifestations such as tall stature, chest wall abnormality, and scoliosis. These primary skeletal manifestations affect the growth pattern in MFS. Therefore, it is not appropriate to use normal growth charts to evaluate the growth status of MFS. We aimed to develop disease-specific growth charts for Korean MFS patients and to use these growth charts for understanding the growth patterns in MFS and managing of patients with MFS. Anthropometric data were available from 187 males and 152 females with MFS through a retrospective review of medical records. Disease-specific growth charts were generated and 3, 25, 50, 75, and 97 percentiles were calculated using the LMS (refers to λ, μ, and σ, respectively) smoothing procedure for height and weight. Comparisons between MFS patients and the general population were performed using a one-sample t-test. With regard to the height, the 50th percentile of MFS is above the normative 97th percentile in both genders. With regard to the weight, the 50 percentile of MFS is above the normative 75th percentile in male and between the normative 50th percentile and the 75th percentile in female. The disease-specific growth charts for Korean patients with MFS can be useful for monitoring growth patterns, planning the timing of growth-reductive therapy, predicting adult height and recording responses to growth-reductive therapy.

  5. Nutritional status influences generic and disease-specific quality of life measures in haemodialysis patients.

    Science.gov (United States)

    Moreira, Ana Catarina; Carolino, Elisabete; Domingos, Fernando; Gaspar, Augusta; Ponce, Pedro; Camilo, María Ermelinda

    2013-01-01

    Poor nutritional status and worse healthrelated quality of life (QoL) have been reported in haemodialysis (HD) patients. The utilization of generic and disease specific QoL questionnaires in the same population may provide a better understanding of the significance of nutrition in QoL dimensions. To assess nutritional status by easy to use parameters and to evaluate the potential relationship with QoL measured by generic and disease specific questionnaires. Nutritional status was assessed by subjective global assessment adapted to renal patients (SGA), body mass index (BMI), nutritional intake and appetite. QoL was assessed by the generic EuroQoL and disease specific Kidney Disease Quality of Life-Short Form (KDQoL-SF) questionnaires. The study comprised 130 patients of both genders, mean age 62.7 ± 14.7 years. The prevalence of undernutrition ranged from 3.1% by BMI ≤ 18.5 kg/m² to 75.4% for patients below energy and protein intake recommendations. With the exception of BMI classification, undernourished patients had worse scores in nearly all QoL dimensions (EuroQoL and KDQoL-SF), a pattern which was dominantly maintained when adjusted for demographics and disease-related variables. Overweight/ obese patients (BMI ≥ 25) also had worse scores in some QoL dimensions, but after adjustment the pattern was maintained only in the symptoms and problems dimension of KDQoL-SF (p = 0.011). Our study reveals that even in mildly undernourished HD patients, nutritional status has a significant impact in several QoL dimensions. The questionnaires used provided different, almost complementary perspectives, yet for daily practice EuroQoL is simpler. Assuring a good nutritional status, may positively influence QoL. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

  6. Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers

    Science.gov (United States)

    Chen, Hao; Zhu, Zhitu; Zhu, Yichun; Wang, Jian; Mei, Yunqing; Cheng, Yunfeng

    2015-01-01

    It is known that a disease is rarely a consequence of an abnormality of a single gene, but reflects the interactions of various processes in a complex network. Annotated molecular networks offer new opportunities to understand diseases within a systems biology framework and provide an excellent substrate for network-based identification of biomarkers. The network biomarkers and dynamic network biomarkers (DNBs) represent new types of biomarkers with protein–protein or gene–gene interactions that can be monitored and evaluated at different stages and time-points during development of disease. Clinical bioinformatics as a new way to combine clinical measurements and signs with human tissue-generated bioinformatics is crucial to translate biomarkers into clinical application, validate the disease specificity, and understand the role of biomarkers in clinical settings. In this article, the recent advances and developments on network biomarkers and DNBs are comprehensively reviewed. How network biomarkers help a better understanding of molecular mechanism of diseases, the advantages and constraints of network biomarkers for clinical application, clinical bioinformatics as a bridge to the development of diseases-specific, stage-specific, severity-specific and therapy predictive biomarkers, and the potentials of network biomarkers are also discussed. PMID:25560835

  7. Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers.

    Science.gov (United States)

    Chen, Hao; Zhu, Zhitu; Zhu, Yichun; Wang, Jian; Mei, Yunqing; Cheng, Yunfeng

    2015-02-01

    It is known that a disease is rarely a consequence of an abnormality of a single gene, but reflects the interactions of various processes in a complex network. Annotated molecular networks offer new opportunities to understand diseases within a systems biology framework and provide an excellent substrate for network-based identification of biomarkers. The network biomarkers and dynamic network biomarkers (DNBs) represent new types of biomarkers with protein-protein or gene-gene interactions that can be monitored and evaluated at different stages and time-points during development of disease. Clinical bioinformatics as a new way to combine clinical measurements and signs with human tissue-generated bioinformatics is crucial to translate biomarkers into clinical application, validate the disease specificity, and understand the role of biomarkers in clinical settings. In this article, the recent advances and developments on network biomarkers and DNBs are comprehensively reviewed. How network biomarkers help a better understanding of molecular mechanism of diseases, the advantages and constraints of network biomarkers for clinical application, clinical bioinformatics as a bridge to the development of diseases-specific, stage-specific, severity-specific and therapy predictive biomarkers, and the potentials of network biomarkers are also discussed. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  8. Disease-specific hashtags and the creation of Twitter medical communities in hematology and oncology.

    Science.gov (United States)

    Pemmaraju, Naveen; Thompson, Michael A; Qazilbash, Muzaffar

    2017-10-01

    Twitter is being increasingly used for information gathering and dissemination of ideas in both medical practice and scientific research. A major limitation to its use has been the surplus of available information and difficulty in categorizing that information into topics of individual interest. However, a Twitter feature known as the hashtag (#), which denotes a specific category or topic, helps in streamlining this wealth of information. The creation and adoption of disease-specific hashtags by healthcare stakeholders has led to a greater uniformity of medical discussions that can be retrieved and referenced at later time-points. As new disease-specific hashtags are created for hematologic and oncologic diseases, more users can connect across the world, even for the rarest of cancer subtypes. A major challenge for this emerging application will be the development of specific and easily identifiable hashtags over time to add more clarity, while still trying to grow Twitter users and expand its reach. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Modeling the Cumulative Effects of Social Exposures on Health: Moving beyond Disease-Specific Models

    Directory of Open Access Journals (Sweden)

    Heather L. White

    2013-03-01

    Full Text Available The traditional explanatory models used in epidemiology are “disease specific”, identifying risk factors for specific health conditions. Yet social exposures lead to a generalized, cumulative health impact which may not be specific to one illness. Disease-specific models may therefore misestimate social factors’ effects on health. Using data from the Canadian Community Health Survey and Canada 2001 Census we construct and compare “disease-specific” and “generalized health impact” (GHI models to gauge the negative health effects of one social exposure: socioeconomic position (SEP. We use logistic and multinomial multilevel modeling with neighbourhood-level material deprivation, individual-level education and household income to compare and contrast the two approaches. In disease-specific models, the social determinants under study were each associated with the health conditions of interest. However, larger effect sizes were apparent when outcomes were modeled as compound health problems (0, 1, 2, or 3+ conditions using the GHI approach. To more accurately estimate social exposures’ impacts on population health, researchers should consider a GHI framework.

  10. EVALUATION OF SILICA MONOLITHS IN AFFINITY MICROCOLUMNS FOR HIGH-THROUGHPUT ANALYSIS OF DRUG-PROTEIN INTERACTIONS

    OpenAIRE

    Yoo, Michelle J.; Hage, David S.

    2009-01-01

    Silica monoliths in affinity microcolumns were tested for the high-throughput analysis of drug-protein interactions. Human serum albumin (HSA) was used as a model protein for this work, while carbamazepine and R-warfarin were used as model analytes. A comparison of HSA silica monoliths of various lengths indicated columns as short as 1 to 3 mm could be used to provide reproducible estimates of retention factors or plate heights. Benefits of using smaller columns for this work included the low...

  11. Relapse and disease specific survival in 1143 Danish women diagnosed with borderline ovarian tumours (BOT)

    DEFF Research Database (Denmark)

    Schou Karlsen, Nikoline Marie; Karlsen, Mona Aarenstrup; Høgdall, Estrid

    2016-01-01

    OBJECTIVE: The aim of the study was to evaluate the rate of relapse as well as disease-free, overall, and disease-specific survival in women with borderline ovarian tumour (BOT). Furthermore, the study aims to identify the clinical parameters correlated to relapse. METHODS: National clinical data...... of women diagnosed with BOT from January 2005 to January 2013 constituted the basis for our study population. The prognostic influence of clinical variables was evaluated using univariate and multivariate analyses. RESULTS: A total of 1143 women were eligible for analysis, with 87.9% in FIGO stage I and 12...... presence, serous histology, implants and microinvasion of the tumour were significantly associated with relapse in univariate analyses. The overall five-year survival rate was 92.2% in FIGO stage I and 89.0% in FIGO stages II-IV. Out of 77 deaths in total, only seven women died from BOT. CONCLUSIONS...

  12. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

    Directory of Open Access Journals (Sweden)

    Meng-Lu Liu

    2016-01-01

    Full Text Available Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS. Here, we show that adult human skin fibroblasts can be directly and efficiently converted into highly pure motor neurons without passing through an induced pluripotent stem cell stage. These adult human induced motor neurons (hiMNs exhibit the cytological and electrophysiological features of spinal motor neurons and form functional neuromuscular junctions (NMJs with skeletal muscles. Importantly, hiMNs converted from ALS patient fibroblasts show disease-specific degeneration manifested through poor survival, soma shrinkage, hypoactivity, and an inability to form NMJs. A chemical screen revealed that the degenerative features of ALS hiMNs can be remarkably rescued by the small molecule kenpaullone. Taken together, our results define a direct and efficient strategy to obtain disease-relevant neuronal subtypes from adult human patients and reveal their promising value in disease modeling and drug identification.

  13. A validated disease specific prediction equation for resting metabolic rate in underweight patients with COPD

    Directory of Open Access Journals (Sweden)

    Anita Nordenson

    2010-09-01

    Full Text Available Anita Nordenson2, Anne Marie Grönberg1,2, Lena Hulthén1, Sven Larsson2, Frode Slinde11Department of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; 2Department of Internal Medicine/Respiratory Medicine and Allergology, Sahlgrenska Academy at University of Gothenburg, SwedenAbstract: Malnutrition is a serious condition in chronic obstructive pulmonary disease (COPD. Successful dietary intervention calls for calculations of resting metabolic rate (RMR. One disease-specific prediction equation for RMR exists based on mainly male patients. To construct a disease-specific equation for RMR based on measurements in underweight or weight-losing women and men with COPD, RMR was measured by indirect calorimetry in 30 women and 11 men with a diagnosis of COPD and body mass index <21 kg/m2. The following variables, possibly influencing RMR were measured: length, weight, middle upper arm circumference, triceps skinfold, body composition by dual energy x-ray absorptiometry and bioelectrical impedance, lung function, and markers of inflammation. Relations between RMR and measured variables were studied using univariate analysis according to Pearson. Gender and variables that were associated with RMR with a P value <0.15 were included in a forward multiple regression analysis. The best-fit multiple regression equation included only fat-free mass (FFM: RMR (kJ/day = 1856 + 76.0 FFM (kg. To conclude, FFM is the dominating factor influencing RMR. The developed equation can be used for prediction of RMR in underweight COPD patients.Keywords: pulmonary disease, chronic obstructive, basal metabolic rate, malnutrition, body composition

  14. Evaluation of silica monoliths in affinity microcolumns for high-throughput analysis of drug-protein interactions.

    Science.gov (United States)

    Yoo, Michelle J; Hage, David S

    2009-08-01

    Silica monoliths in affinity microcolumns were tested for the high-throughput analysis of drug-protein interactions. HSA was used as a model protein for this work, while carbamazepine and R-warfarin were used as model analytes. A comparison of HSA silica monoliths of various lengths indicated columns as short as 1 to 3 mm could be used to provide reproducible estimates of retention factors or plate heights. Benefits of using smaller columns for this work included the lower retention times and lower back pressures that could be obtained versus traditional HPLC affinity columns, as well as the smaller amount of protein that is required for column preparation. One disadvantage of decreasing column length was the lower precision that resulted in retention factor and plate height measurements. A comparison was also made between microcolumns containing silica particles versus silica monoliths. It was demonstrated with R-warfarin that supports could be used in HSA microcolumns for the determination of retention factors or plate heights. However, the higher efficiency of the silica monolith made this the preferred support for work at higher flow rates or when a larger number of plates are needed during the rapid analysis of drug-protein interactions.

  15. Determination of rate constants and equilibrium constants for solution-phase drug-protein interactions by ultrafast affinity extraction.

    Science.gov (United States)

    Zheng, Xiwei; Li, Zhao; Podariu, Maria I; Hage, David S

    2014-07-01

    A method was created on the basis of ultrafast affinity extraction to determine both the dissociation rate constants and equilibrium constants for drug-protein interactions in solution. Human serum albumin (HSA), an important binding agent for many drugs in blood, was used as both a model soluble protein and as an immobilized binding agent in affinity microcolumns for the analysis of free drug fractions. Several drugs were examined that are known to bind to HSA. Various conditions to optimize in the use of ultrafast affinity extraction for equilibrium and kinetic studies were considered, and several approaches for these measurements were examined. The dissociation rate constants obtained for soluble HSA with each drug gave good agreement with previous rate constants reported for the same drugs or other solutes with comparable affinities for HSA. The equilibrium constants that were determined also showed good agreement with the literature. The results demonstrated that ultrafast affinity extraction could be used as a rapid approach to provide information on both the kinetics and thermodynamics of a drug-protein interaction in solution. This approach could be extended to other systems and should be valuable for high-throughput drug screening or biointeraction studies.

  16. Factors associated with disease-specific survival of patients with non-small cell lung cancer.

    Science.gov (United States)

    Souza, Mirian Carvalho de; Cruz, Oswaldo Gonçalves; Vasconcelos, Ana Glória Godoi

    2016-01-01

    Lung cancer is a global public health problem and is associated with high mortality. Lung cancer could be largely avoided by reducing the prevalence of smoking. The objective of this study was to analyze the effects of social, behavioral, and clinical factors on the survival time of patients with non-small cell lung cancer treated at Cancer Hospital I of the José Alencar Gomes da Silva National Cancer Institute, located in the city of Rio de Janeiro, Brazil, between 2000 and 2003. This was a retrospective hospital cohort study involving 1,194 patients. The 60-month disease-specific survival probabilities were calculated with the Kaplan-Meier method for three stage groups. The importance of the studied factors was assessed with a hierarchical theoretical model after adjustment by Cox multiple regression. The estimated 60-month specific-disease lethality rate was 86.0%. The 60-month disease-specific survival probability ranged from 25.0% (stages I/II) to 2.5% (stage IV). The performance status, the intention to treat, and the initial treatment modality were the major prognostic factors identified in the study population. In this cohort of patients, the disease-specific survival probabilities were extremely low. We identified no factors that could be modified after the diagnosis in order to improve survival. Primary prevention, such as reducing the prevalence of smoking, is still the best method to reduce the number of people who will suffer the consequences of lung cancer. O câncer de pulmão é um problema de saúde pública global e é associado a elevada mortalidade. Ele poderia ser evitado em grande parte com a redução da prevalência do tabagismo. O objetivo deste estudo foi analisar os efeitos de fatores sociais, comportamentais e clínicos sobre o tempo de sobrevida de pacientes com câncer de pulmão de células não pequenas atendidos, entre 2000 e 2003, no Hospital do Câncer I do Instituto Nacional de Câncer José Alencar Gomes da Silva, localizado na

  17. Cross-sectional and longitudinal construct validity of two rotator cuff disease-specific outcome measures

    Directory of Open Access Journals (Sweden)

    van Osnabrugge Varda

    2006-03-01

    Full Text Available Abstract Background Disease-specific Quality Of Life (QOL measures are devised to assess the impact of a specific disease across a spectrum of important domains of life. The purpose of this study was to examine the cross-sectional and longitudinal construct validity (sensitivity to change of two rotator cuff disease-specific measures, the Rotator Cuff-Quality Of Life (RC-QOL and the Western Ontario Rotator Cuff (WORC index, in relation to one another and to other joint and limb specific measures in the same population of the patients suffering from rotator cuff pathology. Methods Participants enrolled were consecutive patients who received physical therapy for management of impingement syndrome or received treatment following rotator cuff repair, acromioplasty or decompression surgeries. All subjects received physical therapy treatment and completed four outcome measures at 3 single points (initial, interim, and final. Cross-sectional convergent validity was assessed at each of the 3 time-points by correlating the WORC and RC-QOL's scores to each other and to two alternative scales; a joint-specific scale, the American Shoulder and Elbow Surgeons (ASES standardized shoulder assessment form and a limb-specific measure, the Upper Extremity Functional Index (UEFI. Non-parametric statistics (Spearman's rho and Wilcoxon-Mann-Whitney tests examined the construct validity. The standardized response mean (SRM was used to examine sensitivity to change. Results Forty-one participants entered the study and their scores were compared at 3 cross sectional single points. The correlation coefficients among the 4 measures varied from 0.60 to 0.91. Correlation between corresponding domains of the WORC and RC-QOL varied from 0.45 to 0.85. The known group validity was not significantly different among individual sub-scores and total scores. The final SRMs were (1.42, (1.43, (1.44, and (1.54 for the ASES, RCQOL, WORC, and UEFI respectively. Conclusion The WORC and

  18. Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation

    Directory of Open Access Journals (Sweden)

    Lawrence Wing-Chi Chan

    2014-08-01

    Full Text Available Molecular imaging probes can target abnormal gene expression patterns in patients and allow early diagnosis of disease. For selecting a suitable imaging probe, the current Molecular Imaging and Contrast Agent Database (MICAD provides descriptive and qualitative information on imaging probe characteristics and properties. However, MICAD does not support linkage with the expression profiles of target genes. The proposed Disease-specific Imaging Probe Profiling (DIPP database quantitatively archives and presents the gene expression profiles of targets across different diseases, anatomic regions, and subcellular locations, providing an objective reference for selecting imaging probes. The DIPP database was validated with a clinical positron emission tomography (PET study on lung cancer and an in vitro study on neuroendocrine cancer. The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of 11C-choline and [18F]fluoro-2- deoxy-2-D-glucose (FDG, respectively. Their significant overexpressions corresponded to the findings that the uptake rate of FDG increased with tumor size but that of 11C-choline remained constant. Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http://www.polyu.edu.hk/bmi/dipp/.

  19. Patient experience in cystic fibrosis care: Development of a disease-specific questionnaire.

    Science.gov (United States)

    Stahl, Katja; Steinkamp, Gratiana; Ullrich, Gerald; Schulz, Wolfgang; van Koningsbruggen-Rietschel, Silke; Heuer, Hans-Eberhard; Ellemunter, Helmut; Schwarz, Carsten

    2015-06-01

    The aim of this study was to develop valid and reliable disease-specific questionnaires for adult patients with cystic fibrosis and for parents of minors with cystic fibrosis for assessing patient experience with cystic fibrosis care. The pilot versions of the questionnaires were developed based on a literature review, interviews with health professionals and focus groups. A postal survey with two reminders was conducted in 56 German cystic fibrosis centres recruiting 2874 participants. Psychometric evaluation was done via exploratory factor analysis and reliability and regression analysis. The questionnaires' ability to differentiate between subgroups and between cystic fibrosis centres was evaluated. Response rates were 74% for both adult patients and parents. Ten factors were extracted for both the adult and the parents' models (Cronbach's alpha between 0.6 and 0.9), explaining 50% and 48% of the variance, respectively. The factors organisation & access and the doctor-patient/parent-interaction had the highest relevance for a good overall care experience. The questionnaires were able to distinguish between different cystic fibrosis centres. The questionnaires are well suited for use in internal and external quality management of cystic fibrosis care due to their good psychometric properties, the ability to differentiate between centres and its practicability. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  20. Disease-specific clinical trials networks: the example of cystic fibrosis.

    Science.gov (United States)

    De Boeck, Kris; Bulteel, Veerle; Fajac, Isabelle

    2016-06-01

    This article describes the steps of the development and the structure of a disease-specific clinical trials network for cystic fibrosis in Europe. Activities such as reviewing study protocols, feasibility assessments, training and standardizing of procedures, and outcome measurements help to bring high-quality clinical trials to the patients. Cooperation with the pharmaceutical industry, other research networks, patient organizations, and regulatory agencies is very important throughout all activities. The European Cystic Fibrosis Society-Clinical Trials Network facilitates the development of new treatments for a rare disease and could be a prototype for other diseases. • Clinical research has led to the first approved treatments targeting the basic Cystic Fibrosis defect. • For a rare disease like Cystic Fibrosis, multicenter international collaboration is needed to obtain solid evidence when testing possible new treatments. What is New: • The Clinical Trials Network established by the European Cystic Fibrosis Society has grown to a fully operational network with well-defined structures, procedures and partnerships. • Standardization of outcome parameters, protocol review, feasibility assessment and other activities help to develop high quality, efficient, relevant and feasible clinical trials, with the aim to bring new treatments to the patients.

  1. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Seonmi Park

    2017-04-01

    Full Text Available Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated a diverse, comprehensive, and fully characterized library of sickle-cell-disease-specific induced pluripotent stem cells (iPSCs from patients of different ethnicities, β-globin gene (HBB haplotypes, and fetal hemoglobin (HbF levels. iPSCs stand to revolutionize the way we study human development, model disease, and perhaps eventually, treat patients. Here, we describe this unique resource for the study of sickle cell disease, including novel haplotype-specific polymorphisms that affect disease severity, as well as for the development of patient-specific therapeutics for this phenotypically diverse disorder. As a complement to this library, and as proof of principle for future cell- and gene-based therapies, we also designed and employed CRISPR/Cas gene editing tools to correct the sickle hemoglobin (HbS mutation.

  2. Frontocingular dysfunction in bulimia nervosa when confronted with disease-specific stimuli.

    Science.gov (United States)

    Joos, Andreas A B; Saum, Barbara; Zeeck, Almut; Perlov, Evgeniy; Glauche, Volkmar; Hartmann, Armin; Freyer, Tobias; Sandholz, Angelika; Unterbrink, Thomas; van Elst, Ludger Tebartz; Tüscher, Oliver

    2011-01-01

    Bulimia nervosa (BN) is characterized by dysregulation of impulse control, in other words, uncontrolled eating. Functional neuroimaging studies have been sparse and have used variable methodologies. Thirteen medication-free female BN patients and 13 female healthy controls were investigated by functional magnetic resonance imaging using a disease-specific food paradigm. Stimuli were rated after the scanning procedure. Bulimia nervosa patients showed increased fear ratings and a trend for increased disgust. Magnetic resonance imaging data of 10 BN patients could be analysed. Three BN patients had to be excluded from the analysis because of minimal blood oxygen level dependent signals. Compared with healthy controls, BN patients showed less activation of the anterior cingulate cortex, which extended into the lateral prefrontal cortex. Furthermore, the right temporal pole showed decreased reactivity. This study substantiates a key role of lateral prefrontal dysfunction in BN, a brain region involved in impulse control. Furthermore, the anterior cingulate cortex, which plays a key role in emotion processing, is dysfunctional. A major limitation of this study is the small sample size. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.

  3. Disease-specific mortality burdens in a rural Gambian population using verbal autopsy, 1998–2007

    Directory of Open Access Journals (Sweden)

    Momodou Jasseh

    2014-10-01

    Full Text Available Objective: To estimate and evaluate the cause-of-death structure and disease-specific mortality rates in a rural area of The Gambia as determined using the InterVA-4 model. Design: Deaths and person-years of observation were determined by age group for the population of the Farafenni Health and Demographic Surveillance area from January 1998 to December 2007. Causes of death were determined by verbal autopsy (VA using the InterVA-4 model and ICD-10 disease classification. Assigned causes of death were classified into six broad groups: infectious and parasitic diseases; cancers; other non-communicable diseases; neonatal; maternal; and external causes. Poisson regression was used to estimate age and disease-specific mortality rates, and likelihood ratio tests were used to determine statistical significance. Results: A total of 3,203 deaths were recorded and VA administered for 2,275 (71%. All-age mortality declined from 15 per 1,000 person-years in 1998–2001 to 8 per 1,000 person-years in 2005–2007. Children aged 1–4 years registered the most marked (74% decline from 27 to 7 per 1,000 person-years. Communicable diseases accounted for half (49.9% of the deaths in all age groups, dominated by acute respiratory infections (ARI (13.7%, malaria (12.9% and pulmonary tuberculosis (10.2%. The leading causes of death among infants were ARI (5.59 per 1,000 person-years [95% CI: 4.38–7.15] and malaria (4.11 per 1,000 person-years [95% CI: 3.09–5.47]. Mortality rates in children aged 1–4 years were 3.06 per 1,000 person-years (95% CI: 2.58–3.63 for malaria, and 1.05 per 1,000 person-years (95% CI: 0.79–1.41 for ARI. The HIV-related mortality rate in this age group was 1.17 per 1,000 person-years (95% CI: 0.89–1.54. Pulmonary tuberculosis and communicable diseases other than malaria, HIV/AIDS and ARI were the main killers of adults aged 15 years and over. Stroke-related mortality increased to become the leading cause of death among the

  4. Prevalence-based, disease-specific estimate of the social cost of smoking in Singapore.

    Science.gov (United States)

    Cher, Boon Piang; Chen, Cynthia; Yoong, Joanne

    2017-04-07

    To estimate the cost of smoking in Singapore in 2014 from the societal perspective. A prevalence-based, disease-specific approach was undertaken to estimate the smoking-attributable costs. These include direct and indirect costs of inpatient treatment, premature mortality, loss of productivity due to medical leaves and smoking breaks. In 2014, the social cost of smoking in Singapore was conservatively estimated to be at least US$479.8 million, ∼0.2% of the 2014 gross domestic product. Most of this cost was attributable to productivity losses (US$464.9 million) and largely concentrated in the male population (US$434.9 million). Direct healthcare costs amounted to US$14.9 million where ischaemic heart disease and lung cancer had the highest cost burden. The social cost of smoking is smaller in Singapore than in other Asian countries. However, there is still cause for concern. A recently observed increase in smoking prevalence, particularly among adolescent men, is likely to result in rising total cost. Most significantly, our results suggest that a large share of the overall cost burden lies outside the healthcare system or may not be highly salient to the relevant decision makers. This is partly because of the nature of such costs (indirect or intangible costs such as productivity losses are often not salient) or data limitations (a potentially significant fraction of direct healthcare expenditure may be in private primary care where costs are not systematically captured and reported). The case of Singapore thus illustrates that even in countries perceived as success stories, strong multisectoral anti-tobacco strategies and a supporting research agenda continue to be needed. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  5. Disease-specific quality of life in young patients with tourette syndrome.

    Science.gov (United States)

    Cavanna, Andrea E; Luoni, Chiara; Selvini, Claudia; Blangiardo, Rosanna; Eddy, Clare M; Silvestri, Paola R; Calì, Paola V; Gagliardi, Emanuela; Balottin, Umberto; Cardona, Francesco; Rizzo, Renata; Termine, Cristiano

    2013-02-01

    Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and is often associated with comorbid behavioral problems. Research with generic instruments in child populations showed that comorbid disorders can have a greater impact on health-related quality of life than tic severity. This study investigated the usefulness of a newly developed disease-specific instrument, the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (GTS-QOL-C&A), in assessing health-related quality of life in young patients with Tourette syndrome with and without behavioral comorbidity. We recruited 75 patients with Tourette syndrome (60 males; age 12.4 ± 3.2 years). All participants were evaluated by a neuropsychiatrist and completed a standardized psychometric battery, including the GTS-QOL-C&A, Child Depression Inventory, and Multidimensional Anxiety Scale for Children. Forty-two patients (56%) fulfilled diagnostic criteria for at least one comorbidity: obsessive-compulsive disorder (n = 25 patients [33.3%]); attention deficit/hyperactivity disorder (n = 6 patients [8%]); both (n = 11 patients [14.7%]). The GTS-QOL-C&A demonstrated usefulness in differentiating "pure" Tourette syndrome from Tourette syndrome "plus" behavioral problems with regard to health-related quality of life scores for the obsessive-compulsive subscale. In addition to focusing on core tic symptoms, the GTS-QOL-C&A showed sensitivity to the impact of behavioral comorbidities on health-related quality of life and can usefully complement existing nonspecific instruments. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Development of a disease-specific quality of life questionnaire in Addison's disease.

    Science.gov (United States)

    Løvås, Kristian; Curran, Suzanne; Oksnes, Marianne; Husebye, Eystein S; Huppert, Felicia A; Chatterjee, V Krishna K

    2010-02-01

    Patients with Addison's disease reproducibly self-report impairment in specific dimensions of general well-being questionnaires, suggesting particular deficiencies in health-related quality-of-life (HRQoL). We sought to develop an Addison's disease-specific questionnaire (AddiQoL) that could better quantify altered well-being and treatment effects. Design, Setting, Patients, Intervention, and Outcomes: We reviewed the literature to identify HRQoL issues in Addison's disease and interviewed patients and their partners in-depth to explore various symptom domains. A list of items was generated, and nine expert clinicians and five expert patients assessed the list for impact and clarity. A preliminary questionnaire was presented to 100 Addison's outpatients; the number of items was reduced after analysis of the distribution of the responses. The final questionnaire responses were assessed by Cronbach's alpha and Rasch analysis. Published studies of HRQoL in Addison's disease indicated reduced vitality and general health perception and limitations in physical and emotional functioning. In-depth interviews of 14 patients and seven partners emphasized the impact of the disease on the emotional domain. Seventy HRQoL items were generated; after the expert consultation process and pretesting in 100 patients, the number of items was reduced to 36. Eighty-six patients completed the final questionnaire; the responses showed high internal consistency with Cronbach's alpha 0.95 and Person Separation Index 0.94 (Rasch analysis). We envisage AddiQoL having utility in trials of hormone replacement and management of patients with Addison's disease, analogous to similar questionnaires in GH deficiency (AGHDA) and acromegaly (AcroQoL).

  7. Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy

    Energy Technology Data Exchange (ETDEWEB)

    Surova, Yulia; Hall, Sara; Widner, Haakan [Lund University, Department of Clinical Sciences, Lund (Sweden); Skaane University Hospital, Department of Neurology, Lund (Sweden); Nilsson, Markus [Lund University, Lund University Bioimaging Center, Lund (Sweden); Laett, Jimmy [Skaane University Hospital, Center for Medical Imaging and Physiology, Lund (Sweden); Lampinen, Bjoern [Lund University, Department of Medical Radiation Physics, Lund (Sweden); Lindberg, Olof [Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Nilsson, Christer [Skaane University Hospital, Department of Neurology, Lund (Sweden); Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Westen, Danielle van [Lund University, Department of Clinical Sciences, Lund (Sweden); Skaane University Hospital, Center for Medical Imaging and Physiology, Lund (Sweden); Hansson, Oskar [Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Skaane University Hospital, Memory Clinic, Lund (Sweden)

    2015-11-15

    The aim of this study is to identify disease-specific changes of the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), and multiple system atrophy with predominant parkinsonism (MSA-P) using diffusion tensor imaging and volumetric analysis. MRI diffusion and volumetric data were acquired in a derivation of 30 controls and 8 patients with PSP and a validation cohort comprised of controls (n = 21) and patients with PSP (n = 27), PD (n = 10), and MSA-P (n = 11). Analysis was performed using regions of interest (ROI), tract-based spatial statistic (TBSS), and tractography and results compared between diagnostic groups. In the derivation cohort, we observed increased mean diffusivity (MD) in the thalamus, superior cerebellar peduncle, and the midbrain in PSP compared to controls. Furthermore, volumetric analysis showed reduced thalamic volumes in PSP. In the validation cohort, the observations of increased MD were replicated by ROI-based analysis and in the thalamus by TBSS-based analysis. Such differences were not found for patients with PD in any of the cohorts. Tractography of the dentatorubrothalamic tract (DRTT) showed increased MD in PSP patients from both cohorts compared to controls and in the validation cohort in PSP compared to PD and MSA patients. Increased MD in the thalamus and along the DRTT correlated with disease stage and motor function in PSP. Patients with PSP, but not PD or MSA-P, exhibit signs of structural abnormalities in the thalamus and in the DRTT. These changes are associated with disease stage and impaired motor function. (orig.)

  8. A Disease-Specific Hybrid Rotation Increases Opportunities for Deliberate Practice.

    Science.gov (United States)

    Cook, Mackenzie R; Graff-Baker, Amanda N; Moren, Alexis M; Brown, Sarah; Fair, Kelly A; Kiraly, Laszlo N; De La Melena, Violeta Tammy; Pommier, SuEllen J; Deveney, Karen E

    2016-01-01

    Incorporating deliberate practice (DP) into residency curricula may optimize education. DP includes educationally protected time, continuous expert feedback, and a focus on a limited number of technical skills. It is strongly associated with mastery level learning. Determine if a multidisciplinary breast rotation (MDB) increases DP opportunities. Beginning in 2010, interns completed the 4-week MDB. Three days a week were spent in surgery and surgical clinic. Half-days were in breast radiology, pathology, medical oncology, and didactics. The MDB was retrospectively compared with a traditional community rotation (TCR) and a university surgical oncology service (USOS) using rotation feedback and resident operative volume. Data are presented as mean ± standard deviation. Oregon Health and Science University in Portland, Oregon; an academic tertiary care general surgery residency program. General surgery residents at Oregon Health and Science University participating in either the MDB, TCR or USOS. A total of 31 interns rated the opportunity to perform procedures significantly higher for MDB than TCR or USOS (4.6 ± 0.6 vs 4.2 ± 0.9 and 4.1 ± 1.0, p < 0.05). MDB was rated higher than TCR on quality of faculty teaching and educational materials (4.5 ± 0.7 vs 4.1 ± 0.9 and 4.0 ± 1.2 vs 3.5 ± 1.0, p < 0.05). Interns operated more on the MDB than on the USOS and were more focused on breast resections, lymph node dissections, and port placements than on the traditional surgical rotation or USOS. The MDB incorporates multidisciplinary care into a unique, disease-specific, and educationally focused rotation. It is highly rated and affords a greater opportunity for DP than either the USOS or TCR. DP is strongly associated with mastery learning and this novel rotation structure could maximize intern education in the era of limited work hours. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  9. Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL) scale

    DEFF Research Database (Denmark)

    Berghöfer, P; Fragkos, K C; Baxter, J P

    2013-01-01

    Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale....

  10. Development and Validation of a Disease-Specific Questionnaire to Assess Patient-Reported Symptoms in Polycystic Liver Disease

    NARCIS (Netherlands)

    Neijenhuis, M.K.; Gevers, T.J.; Hogan, M.C.; Kamath, P.S.; Wijnands, T.F.; Ouweland, R.C. van den; Edwards, M.E.; Sloan, J.A.; Kievit, W.; Drenth, J.P.

    2016-01-01

    Treatment of polycystic liver disease (PLD) focuses on symptom improvement. Generic questionnaires lack sensitivity to capture PLD-related symptoms, a prerequisite to determine effectiveness of therapy. We developed and validated a disease-specific questionnaire that assesses symptoms in PLD

  11. Fragrance allergy and quality of life - development and validation of a disease-specific quality of life instrument

    DEFF Research Database (Denmark)

    Heisterberg, Maria V; Menné, Torkil; Johansen, Jeanne D

    2014-01-01

    BACKGROUND: Fragrance allergy is a lifelong condition that may give rise to permanent or recurrent contact dermatitis and may affect quality of life (QoL). The effect on QoL has not yet been investigated, and no disease-specific QoL instrument for fragrance allergy exists. OBJECTIVE: To develop a...

  12. Disease-specific health-related quality of life instruments for IgE-mediated food allergy.

    Science.gov (United States)

    Salvilla, S A; Dubois, A E J; Flokstra-de Blok, B M J; Panesar, S S; Worth, A; Patel, S; Muraro, A; Halken, S; Hoffmann-Sommergruber, K; DunnGalvin, A; Hourihane, J O'B; Regent, L; de Jong, N W; Roberts, G; Sheikh, A

    2014-07-01

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Melanoma patients' disease-specific knowledge, information preference, and appreciation of educational YouTube videos for self-inspection

    NARCIS (Netherlands)

    Damude, S.; Hoekstra-Weebers, J. E. H. M.; van Leeuwen, B. L.; Hoekstra, H. J.

    Background: Informing and educating melanoma patients is important for early detection of a recurrence or second primary. This study aimed to investigate Dutch melanoma patients' disease-specific knowledge, and their opinions on information provision and the value of e-Health videos. Methods: All

  14. Development of a disease specific quality of life questionnaire for patients with Graves' ophthalmopathy: the GO-QOL

    NARCIS (Netherlands)

    Terwee, C. B.; Gerding, M. N.; Dekker, F. W.; Prummel, M. F.; Wiersinga, W. M.

    1998-01-01

    To develop a reliable and valid disease specific quality of life questionnaire (the GO-QOL) for patients with Graves' ophthalmopathy (GO), that can be used to describe the health related quality of life and changes in health related quality of life over time as a consequence of disease and

  15. Disease-specific health-related quality of life instruments for IgE-mediated food allergy

    DEFF Research Database (Denmark)

    Salvilla, S A; Dubois, A E J; Flokstra-de Blok, B M J

    2014-01-01

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires a...

  16. Comparing Effectiveness of Generic and Disease-Specific Self-Management Interventions for People With Diabetes in a Practice Context

    NARCIS (Netherlands)

    Ghahari, S.; Packer, T.L.; Boldy, D.; Melling, L.; Parsons, R.

    2015-01-01

    BACKGROUND: The effectiveness of self-management interventions has been demonstrated. However, the benefits of generic vs. disease-specific programs are unclear, and their efficacy within a practice setting has yet to be fully explored. OBJECTIVE: To compare the outcomes of the diabetes-specific

  17. Disease-specific health-related quality of life instruments for IgE-mediated food allergy

    NARCIS (Netherlands)

    Salvilla, S. A.; Dubois, A. E. J.; Flokstra-de Blok, B. M. J.; Panesar, S. S.; Worth, A.; Patel, S.; Muraro, A.; Halken, S.; Hoffmann-Sommergruber, K.; DunnGalvin, A.; Hourihane, J. O.'B.; Regent, L.; de Jong, N. W.; Roberts, G.; Sheikh, A.; Bindslev Jensen, C.; Cardona, V.; Eigenmann, P.; Papadopoulos, N.; Vlieg-Boerstra, B.; Akdis, C. A.

    2014-01-01

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are

  18. Disease-specific health-related quality of life instruments for IgE-mediated food allergy

    NARCIS (Netherlands)

    Salvilla, S. A.; Dubois, A. E. J.; Flokstra-de Blok, Bertine; Panesar, S. S.; Worth, A.; Patel, S.; Muraro, A.; Halken, S.; Hoffmann-Sommergruber, K.; DunnGalvin, A.; Hourihane, J. O'B.; Regent, L.; de Jong, N. W.; Roberts, G.; Sheikh, A.

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are

  19. Application of a disease-specific mapping function to estimate utility gains with effective treatment of schizophrenia

    Directory of Open Access Journals (Sweden)

    Rupnow Marcia FT

    2005-09-01

    Full Text Available Abstract Background Most tools for estimating utilities use clinical trial data from general health status models, such as the 36-Item Short-Form Health Survey (SF-36. A disease-specific model may be more appropriate. The objective of this study was to apply a disease-specific utility mapping function for schizophrenia to data from a large, 1-year, open-label study of long-acting risperidone and to compare its performance with an SF-36-based utility mapping function. Methods Patients with schizophrenia or schizoaffective disorder by DSM-IV criteria received 25, 50, or 75 mg long-acting risperidone every 2 weeks for 12 months. The Positive and Negative Syndrome Scale (PANSS and SF-36 were used to assess efficacy and health-related quality of life. Movement disorder severity was measured using the Extrapyramidal Symptom Rating Scale (ESRS; data concerning other common adverse effects (orthostatic hypotension, weight gain were collected. Transforms were applied to estimate utilities. Results A total of 474 patients completed the study. Long-acting risperidone treatment was associated with a utility gain of 0.051 using the disease-specific function. The estimated gain using an SF-36-based mapping function was smaller: 0.0285. Estimates of gains were only weakly correlated (r = 0.2. Because of differences in scaling and variance, the requisite sample size for a randomized trial to confirm observed effects is much smaller for the disease-specific mapping function (156 versus 672 total subjects. Conclusion Application of a disease-specific mapping function was feasible. Differences in scaling and precision suggest the clinically based mapping function has greater power than the SF-36-based measure to detect differences in utility.

  20. Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates.

    Science.gov (United States)

    Yoo, Michelle J; Hage, David S

    2011-04-15

    This report examined the use of silica monoliths in affinity microcolumns containing human serum albumin (HSA) to measure the dissociation rates for various drugs from this protein. Immobilized HSA and control monolith columns with dimensions of 1 mm × 4.6 mm i.d. were prepared for this work and used with a noncompetitive peak decay method. Several drugs known to bind HSA were examined, such as warfarin, diazepam, imipramine, acetohexamide, and tolbutamide. Items that were studied and optimized in this method included the sample volume, sample concentration, and elution flow rate. It was found that flow rates up to 10 mL/min could be used in this approach. Work with HSA silica monoliths at these high flow rates made it possible to provide dissociation rate constants for drugs such as warfarin in less than 40s. The dissociation rate constants that were measured gave good agreement with values reported in the literature or that had been obtained with other solutes that had similar binding affinities for HSA. This approach is a general one that should be useful in examining the dissociation of other drugs from HSA and in providing a high-throughput method for screening drug-protein interactions. Copyright © 2010 Elsevier B.V. All rights reserved.

  1. Detection of First-Line Drug Resistance Mutations and Drug-Protein Interaction Dynamics from Tuberculosis Patients in South India.

    Science.gov (United States)

    Nachappa, Somanna Ajjamada; Neelambike, Sumana M; Amruthavalli, Chokkanna; Ramachandra, Nallur B

    2017-08-16

    Diagnosis of drug-resistant tuberculosis predominantly relies on culture-based drug susceptibility testing, which take weeks to produce a result and a more time-efficient alternative method is multiplex allele-specific PCR (MAS-PCR). Also, understanding the role of mutations in causing resistance helps better drug designing. To evaluate the ability of MAS-PCR in the detection of drug resistance and to understand the mechanism of interaction of drugs with mutant proteins in Mycobacterium tuberculosis. Detection of drug-resistant mutations using MAS-PCR and validation through DNA sequencing. MAS-PCR targeted five loci on three genes, katG 315 and inhA -15 for the drug isoniazid (INH), and rpoB 516, 526, and 531 for rifampicin (RIF). Furthermore, the sequence data were analyzed to study the effect on interaction of the anti-TB drug molecule with the target protein using in silico docking. We identified drug-resistant mutations in 8 out of 114 isolates with 2 of them as multidrug-resistant TB using MAS-PCR. DNA sequencing confirmed only six of these, recording a sensitivity of 85.7% and specificity of 99.3% for MAS-PCR. Molecular docking showed estimated free energy of binding (ΔG) being higher for RIF binding with RpoB S531L mutant. Codon 315 in KatG does not directly interact with INH but blocks the drug access to active site. We propose DNA sequencing-based drug resistance detection for TB, which is more accurate than MAS-PCR. Understanding the action of resistant mutations in disrupting the normal drug-protein interaction aids in designing effective drug alternatives.

  2. Entrapment of Alpha1-Acid Glycoprotein in High-Performance Affinity Columns for Drug-Protein Binding Studies

    Science.gov (United States)

    Bi, Cong; Jackson, Abby; Vargas-Badilla, John; Li, Rong; Rada, Giana; Anguizola, Jeanethe; Pfaunmiller, Erika; Hage, David S.

    2015-01-01

    A slurry-based method was developed for the entrapment of alpha1-acid glycoprotein (AGP) for use in high-performance affinity chromatography to study drug interactions with this serum protein. Entrapment was achieved based on the physical containment of AGP in hydrazide-activated porous silica supports and by using mildly oxidized glycogen as a capping agent. The conditions needed for this process were examined and optimized. When this type of AGP column was used in binding studies, the association equilibrium constant (Ka) measured by frontal analysis at pH 7.4 and 37°C for carbamazepine with AGP was found to be 1.0 (± 0.5) × 105 M−1, which agreed with a previously reported value of 1.0 (± 0.1) × 105 M−1. Binding studies based on zonal elution were conducted for several other drugs with such columns, giving equilibrium constants that were consistent with literature values. An entrapped AGP column was also used in combination with a column containing entrapped HSA in a screening assay format to compare the binding of various drugs to AGP and HSA. These results also agreed with previous data that have been reported in literature for both of these proteins. The same entrapment method could be extended to other proteins and to the investigation of additional types of drug-protein interactions. Potential applications include the rapid quantitative analysis of biological interactions and the high-throughput screening of drug candidates for their binding to a given protein. PMID:26627938

  3. Analysis of drug-protein interactions by high-performance affinity chromatography: interactions of sulfonylurea drugs with normal and glycated human serum albumin.

    Science.gov (United States)

    Matsuda, Ryan; Anguizola, Jeanethe; Hoy, Krina S; Hage, David S

    2015-01-01

    High-performance affinity chromatography (HPAC) is a type of liquid chromatography that has seen growing use as a tool for the study of drug-protein interactions. This report describes how HPAC can be used to provide information on the number of binding sites, equilibrium constants, and changes in binding that can occur during drug-protein interactions. This approach will be illustrated through recent data that have been obtained by HPAC for the binding of sulfonylurea drugs and other solutes to the protein human serum albumin (HSA), and especially to forms of this protein that have been modified by non-enzymatic glycation. The theory and use of both frontal analysis and zonal elution competition studies in such work will be discussed. Various practical aspects of these experiments will be presented, as well as factors to consider in the extension of these methods to other drugs and proteins or additional types of biological interactions.

  4. Building calculations

    DEFF Research Database (Denmark)

    Jensen, Bjarne Christian; Hansen, Svend Ole

    Textbook on design of large panel building including rules on robustness and a method for producing the Statical documentattion......Textbook on design of large panel building including rules on robustness and a method for producing the Statical documentattion...

  5. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    IBACOS researched the constructability and viability issues of using high performance windows as one component of a larger approach to building houses that achieve the Building America 70% energy savings target.

  6. Keeping health facilities safe: one way of strengthening the interaction between disease-specific programmes and health systems.

    Science.gov (United States)

    Harries, Anthony D; Zachariah, Rony; Tayler-Smith, Katie; Schouten, Erik J; Chimbwandira, Frank; Van Damme, Wim; El-Sadr, Wafaa M

    2010-12-01

    The debate on the interaction between disease-specific programmes and health system strengthening in the last few years has intensified as experts seek to tease out common ground and find solutions and synergies to bridge the divide. Unfortunately, the debate continues to be largely academic and devoid of specificity, resulting in the issues being irrelevant to health care workers on the ground. Taking the theme 'What would entice HIV- and tuberculosis (TB)-programme managers to sit around the table on a Monday morning with health system experts', this viewpoint focuses on infection control and health facility safety as an important and highly relevant practical topic for both disease-specific programmes and health system strengthening. Our attentions, and the examples and lessons we draw on, are largely aimed at sub-Saharan Africa where the great burden of TB and HIV ⁄ AIDS resides, although the principles we outline would apply to other parts of the world as well. Health care infections, caused for example by poor hand hygiene, inadequate testing of donated blood, unsafe disposal of needles and syringes, poorly sterilized medical and surgical equipment and lack of adequate airborne infection control procedures, are responsible for a considerable burden of illness amongst patients and health care personnel, especially in resource-poor countries. Effective infection control in a district hospital requires that all the components of a health system function well: governance and stewardship, financing,infrastructure, procurement and supply chain management, human resources, health information systems, service delivery and finally supervision. We argue in this article that proper attention to infection control and an emphasis on safe health facilities is a concrete first step towards strengthening the interaction between disease-specific programmes and health systems where it really matters – for patients who are sick and for the health care workforce who provide

  7. Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation

    Science.gov (United States)

    Price, Victoria E; Klaassen, Robert J; Bolton-Maggs, Paula HB; Grainger, John D; Curtis, Christine; Wakefield, Cindy; Dufort, Gustavo; Riedlinger, Arne; Soltner, Christophe; Blanchette, Victor S; Young, Nancy L

    2009-01-01

    Background Disease-specific quality of life (QoL) measures have enhanced the capacity of outcome measures to evaluate subtle changes and differences between groups. However, when the specific disease is rare, the cohort of patients is small and international collaboration is often necessary to accomplish meaningful research. As many of the QoL measures have been developed in North American English, they require translation to ensure their usefulness in a multi-cultural and/or international society. Published guidelines provide formal methods to achieve cross-culturally comparable versions of a QoL tool. However, these guidelines describe a rigorous process that is not always feasible, particularly in rare disease groups. The objective of this manuscript is to describe the process that was developed to achieve accurate cross-cultural translations of a disease-specific QoL measure, to overcome the challenges of a small sample size, i.e. children with a rare disorder. Procedure A measurement study was conducted in the United Kingdom (UK), France, Germany and Uruguay, during which the validated measure was translated into the languages of the respective countries. Results This is a report of a modified, child-centric, cross-cultural translation and adaptation process in which culturally appropriate and methodologically valid translations of a disease-specific QoL measure, the Kids' ITP Tools (KIT), were performed in children with immune thrombocytopenic purpura (ITP). The KIT was translated from North American English into UK English, French, German, and Spanish. Conclusion This study was a successful international collaboration. The modified process through which culturally appropriate and methodologically valid translations of QoL measures may be achieved in a pediatric population with a relatively rare disorder is reported. PMID:19852803

  8. Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women.

    Science.gov (United States)

    Hodgson, Jonathan M; Prince, Richard L; Woodman, Richard J; Bondonno, Catherine P; Ivey, Kerry L; Bondonno, Nicola; Rimm, Eric B; Ward, Natalie C; Croft, Kevin D; Lewis, Joshua R

    2016-03-14

    Higher fruit intake is associated with lower risk of all-cause and disease-specific mortality. However, data on individual fruits are limited, and the generalisability of these findings to the elderly remains uncertain. The objective of this study was to examine the association of apple intake with all-cause and disease-specific mortality over 15 years in a cohort of women aged over 70 years. Secondary analyses explored relationships of other fruits with mortality outcomes. Usual fruit intake was assessed in 1456 women using a FFQ. Incidence of all-cause and disease-specific mortality over 15 years was determined through the Western Australian Hospital Morbidity Data system. Cox regression was used to determine the hazard ratios (HR) for mortality. During 15 years of follow-up, 607 (41·7%) women died from any cause. In the multivariable-adjusted analysis, the HR for all-cause mortality was 0·89 (95% CI 0·81, 0·97) per sd (53 g/d) increase in apple intake, HR 0·80 (95% CI 0·65, 0·98) for consumption of 5-100 g/d and HR 0·65 (95% CI 0·48, 0·89) for consumption of >100 g/d (an apple a day), compared with apple intake of apple intake was associated with lower risk for cancer mortality, and that higher total fruit and banana intakes were associated lower risk of CVD mortality (Papple consumption may contribute to lower risk of mortality.

  9. The Comparison of WHOQOL-BREF with Disease Specific Heath Related Quality of Life Questionnaire in Irritable Bowel Syndrome

    Directory of Open Access Journals (Sweden)

    M. Biglari

    2015-11-01

    Full Text Available Irritable Bowel Syndrome (IBS is one of the most common gastrointestinal disorders particularly affecting the quality of life (QOL. Evaluating QOL in IBS patients is a valuable method of defining a psychobiological pattern of disease. Various disease specific and general instruments are now available to measure health-related QOL (HRQOL in IBS patients. Though, no comparison has been made between these tools especially in non-western countries. We aimed to compare QOL measures between two specific and general QOL questionnaires in a sample of Iranian IBS patients. A total of 250 IBS patients were diagnosed based on Rome III criteria (mean age 29.6 ± 9.6 years. HRQOL was assessed using disease specific quality of life for IBS (IBS-QOL and generic World Health Organization Quality of Life-BREF (WHOQOL-BREF questionnaires. Patients also completed Speilberger`s “State/Trait Anxiety Inventory” and “Beck Depression Inventory-II” for the evaluation of anxiety and depression symptoms. The severity of symptoms was independently associated with HRQOL in patients using WHOQOL-BREF and IBS-QOL (r = -0.48 and -0.39 respectively, P P value < 0.001. Controlling for anxiety and depression symptoms did not influence the strength of observed correlation. The WHOQOL-BREF is a psychometrically sound, rapid and convenient instrument whose HRQOL measure is as valid and accurate as the disease-specific IBS-QOL questionnaire. It seems reasonable to use the WHOQOL-BREF alongside the IBS-QOL.

  10. The Comparison of WHOQOL-BREF with Disease Specific Heath Related Quality of Life Questionnaire in Irritable Bowel Syndrome.

    Science.gov (United States)

    Jamali, Raika; Biglari, Mohammad

    2015-11-01

    Irritable Bowel Syndrome (IBS) is one of the most common gastrointestinal disorders particularly affecting the quality of life (QOL). Evaluating QOL in IBS patients is a valuable method of defining a psychobiological pattern of disease. Various disease specific and general instruments are now available to measure health-related QOL (HRQOL) in IBS patients. Though, no comparison has been made between these tools especially in non-western countries. We aimed to compare QOL measures between two specific and general QOL questionnaires in a sample of Iranian IBS patients. A total of 250 IBS patients were diagnosed based on Rome III criteria (mean age 29.6 ± 9.6 years). HRQOL was assessed using disease specific quality of life for IBS (IBS-QOL) and generic World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaires. Patients also completed Speilberger`s "State/Trait Anxiety Inventory" and "Beck Depression Inventory-II" for the evaluation of anxiety and depression symptoms. The severity of symptoms was independently associated with HRQOL in patients using WHOQOL-BREF and IBS-QOL (r = -0.48 and -0.39 respectively, P < 0.001). In linear regression analysis, a strong correlation was observed between the HRQOL scores of IBS-QOL and the WHOQOL-BREF questionnaires (standard β = 0.86 (95%CI: 1.15 - 1.44), P value < 0.001). Controlling for anxiety and depression symptoms did not influence the strength of observed correlation. The WHOQOL-BREF is a psychometrically sound, rapid and convenient instrument whose HRQOL measure is as valid and accurate as the disease-specific IBS-QOL questionnaire. It seems reasonable to use the WHOQOL-BREF alongside the IBS-QOL.

  11. Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer.

    Science.gov (United States)

    Kweldam, Charlotte F; Wildhagen, Mark F; Steyerberg, Ewout W; Bangma, Chris H; van der Kwast, Theodorus H; van Leenders, Geert J L H

    2015-03-01

    Patients with Gleason score 7 prostate cancer on radical prostatectomy demonstrate a wide range in clinical outcome. Gleason grade 4 prostate cancer encompasses a heterogeneous group of tumor growth patterns including fused, ill-defined, cribriform, and glomeruloid glandular structures. Our objective was to determine the prognostic value of different Gleason grade 4 growth patterns. We performed a nested case-control study among 535 patients with Gleason score 7 prostate cancer at radical prostatectomy, treated between March 1985 and July 2013 at a university hospital in the Netherlands. We analyzed 52 cases (with metastasis, disease-specific mortality or both) and 109 controls, matched for age, PSA level, and pT stage. Presence of the following Gleason grade 4 patterns was recorded: fused, ill-defined, cribriform, and glomeruloid. Intraductal carcinoma of the prostate and tertiary Gleason grade 5 were additionally assessed. Outcomes were metastasis-free survival and disease-specific survival. We used Cox proportional hazards regression to determine the predictive value of Gleason grade 4 patterns for survival time. The overall prevalence of Gleason grade 4 patterns was as follows: fused 75% (n=121), ill-defined 64% (n=102), cribriform 48% (n=83), and glomeruloid 25% (n=40). Cribriform pattern was the only pattern with an unequal distribution between cases and controls. Forty-two out of 52 cases (81%) had cribriform growth pattern versus 41/109 controls (38%). In multivariate analysis, presence of cribriform growth was an adverse independent predictor for distant metastasis-free survival (HR 8.0, 95% CI 3.0-21; PGleason grade 4 is a strong prognostic marker for distant metastasis and disease-specific death in patients with Gleason score 7 prostate cancer at radical prostatectomy.

  12. Disease-specific death and metastasis do not occur in patients with Gleason score ≤6 at radical prostatectomy.

    Science.gov (United States)

    Kweldam, Charlotte F; Wildhagen, Mark F; Bangma, Chris H; van Leenders, Geert J L H

    2015-08-01

    To assess the metastasis-free survival (MFS) and disease-specific survival (DSS) in men with Gleason score ≤6 prostate cancer at radical prostatectomy (RP). We included 1101 consecutive RP patients operated between March 1985 to July 2013 at a single institution. The outcome variables were MFS and DSS. The postoperative survival was estimated by the Kaplan-Meier method. The Gleason score distribution of the study population (1101 patients) was Gleason score ≤6 (449, 41%), Gleason score 3 + 4 = 7 (436, 40%), Gleason score 4 + 3 = 7 (99, 9%) and Gleason score 8-10 (117, 11%). The median (interquartile range) postoperative follow-up was 100 (48-150) months. During follow-up 197 men (18%) died, of whom 42 (3.8%) died from prostate cancer-related causes. In all, 19/1101 patients (1.7%) had documented lymph node metastasis at the time of RP: none with Gleason score ≤6, seven with Gleason score 3 + 4 = 7 (1.6%), six with Gleason score 4 + 3 = 7 (6.1%) and six with Gleason score 8-10 (5.1%). Distant metastasis occurred in 56/1101 patients (5.1%): none with Gleason score ≤6, 23 with Gleason score 3 + 4 = 7 (5.3%), 17 with Gleason score 4 + 3 = 7 (17%) and 16 with Gleason score 8-10 (14%). Disease-specific death, stratified per Gleason-score group was: none in ≤6, 16 (3.7%) in 3 + 4 = 7, 16 (16%) in 4 + 3 = 7 and 10 (8.5%) in 8-10 group. No metastasis or disease-specific death were seen in men with Gleason score ≤6 prostate cancer at RP, showing the negligible potential to metastasise in this large subgroup of patients with prostate cancer. © 2014 The Authors BJU International © 2014 BJU International Published by John Wiley & Sons Ltd.

  13. General and disease-specific quality of life in patients with chronic suppurative otitis media - a prospective study

    Directory of Open Access Journals (Sweden)

    Plinkert Peter K

    2011-06-01

    Full Text Available Abstract Background Chronic suppurative otitis media (CSOM is frequently associated with symptoms of inflammation like discharge from the ear or pain. In many cases, patients suffer from hearing loss causing communication problems and social withdrawal. The objective of this work was to collect prospective audiological data and data on general and disease-specific quality of life with validated quality of life measurement instruments to assess the impact of the disease on health-related quality of life (HR-QOL. Methods 121 patients were included in the study. Patients were clinically examined in the hospital before and 6 months after surgery including audiological testing. They filled in the quality of life questionnaires SF-36 and Chronic Otitis Media Outcome Test 15 (COMOT-15 pre-operatively and 6 and 12 months post-operatively, respectively. Results Complete data records from 90 patients were available for statistical analysis. Disease-specific HR-QOL in patients with CSOM improved after tympanoplasty in all the scales of the COMOT-15. There was no difference in HR-QOL assessment between patients with mesotympanic respectively epitympanic CSOM. However, we did find the outcome to be worse in patients who received revision surgery compared with those receiving primary surgery. Audiometric findings correlated very well with the subscale hearing function from the COMOT-15 questionnaire. General HR-QOL measured with the SF-36 was not significantly changed by tympanoplasty. Conclusions Tympanoplasty did lead to a significant improvement of disease-specific HR-QOL in patients with CSOM while general HR-QOL did not change. Very well correlations were found between the subscale hearing function from the COMOT-15 questionnaire and audiological findings. Revision surgery seems to be a predictor for a worse outcome.

  14. Solar building

    OpenAIRE

    Zhang, Luxin

    2014-01-01

    In my thesis I describe the utilization of solar energy and solar energy with building integration. In introduction it is also mentioned how the solar building works, trying to make more people understand and accept the solar building. The thesis introduces different types of solar heat collectors. I compared the difference two operation modes of solar water heating system and created examples of solar water system selection. I also introduced other solar building applications. It is conv...

  15. Validation of a New Questionnaire with Generic and Disease-Specific Qualities: The Mcgill Copd Quality of Life Questionnaire

    Directory of Open Access Journals (Sweden)

    Smita Pakhale

    2012-01-01

    Full Text Available BACKGROUND: A validated health-related quality of life questionnaire in chronic obstructive pulmonary disease (COPD with advantages of both generic- and disease-specific questionnaires is needed to capture patients’ perspectives of severity and impact of the disease. The McGill COPD questionnaire was created to include these advantages in English and French. It assesses three domains: symptoms, physical function and feelings with 29 items (12 from the 36-item Short-Form Health Survey with 17 from the previously developed COPD-specific module.

  16. Building envelope

    CSIR Research Space (South Africa)

    Gibberd, Jeremy T

    2009-01-01

    Full Text Available This chapter describes the way building envelopes can contribute to developing green buildings and sets out some objectives that could be aimed for. It also proposes a number of approaches that can be used to help design green building envelopes...

  17. Healthy Buildings?

    Science.gov (United States)

    Grubb, Deborah

    Health problems related to school buildings can be categorized in five major areas: sick-building syndrome; health-threatening building materials; environmental hazards such as radon gas and asbestos; lead poisoning; and poor indoor air quality due to smoke, chemicals, and other pollutants. This paper provides an overview of these areas,…

  18. Validation of the disease-specific quality of life Wuerzburg Wound Score in patients with chronic leg ulcer.

    Science.gov (United States)

    Engelhardt, Michael; Spech, Eva; Diener, Hermann; Faller, Hermann; Augustin, Matthias; Debus, Eike S

    2014-09-01

    Aim of the study was to validate a newly developed disease-specific quality of life questionnaire (Wuerzburg Wound Score, WWS) in patients with chronic arterial or venous leg ulcers. In this prospective study 115 patients with vascular disease associated leg ulcer (54 arterial ulcer, 61 venous ulcer) were studied (mean age 66 ± 11 years, 51 % male). All patients completed the WWS at baseline, and after four and 12 weeks. To assess construct validity additionally all patients completed the generic QoL-questionnaires Short Form-36 (SF-36) and Nottingham Health Profile (NHP). Construct validity and responsiveness of the WWS were tested. WWS showed acceptable construct validity versus SF-36 (r = 0.5 - 0.78; P ulcer. The WWS is a valid measure of disease-specific QoL in patients with leg ulcers and it is more sensitive than the generic instruments in detecting changes of wound healing over time. Further assessment of the psychometric properties of the WWS with larger patient samples is required before the test can be recommended for use in clinical practice.

  19. Disease-specific cardiovascular positron emission tomography/magnetic resonance imaging: a brief review of the current literature

    Science.gov (United States)

    Zheng, Jie

    2016-01-01

    The hybrid positron emission tomography/magnetic resonance (PET/MR) is a new imaging tool that has garnered immense research interest for its potentials to assist clinical investigations. PET/MR combines the quantitative measurement of PET with dynamic functional and anatomic assessment of MR and can deliver a robust clinical examination. Currently, simultaneous cardiovascular PET/MR imaging remains in the pre-clinical research stage, and most institutions have not adopted a clinical PET/MR clinical imaging service. Nevertheless, PET/MR examination has unique promises in several areas of cardiovascular medicine, and in recent years more and more research publications have become available to lend us insight into its utility in cardiovascular imaging. Here we review the existing literature on simultaneous cardiovascular PET/MR imaging, with an emphasis on organizing the current literature into disease-specific discussions. These areas include coronary artery disease (CAD), carotid atherosclerosis, various infiltrative, inflammatory and hereditary heart diseases, myocarditis, vasculitis, and cardiac mass assessment. The purpose of this review is to provide an overview of the current understanding of cardiovascular PET/MR clinical imaging, in a disease-specific manner, from a clinician’s perspective. Potential limitations of simultaneous PET/MR, such as cost effectiveness, artifacts, contraindications, and radiation exposure, are briefly discussed. PMID:27429913

  20. Deep brain stimulation for psychiatric diseases: a pooled analysis of published studies employing disease-specific standardized outcome scales.

    Science.gov (United States)

    Nangunoori, Raj; Tomycz, Nestor D; Quigley, Matthew; Oh, Michael Y; Whiting, Donald M

    2013-01-01

    Deep brain stimulation (DBS) has emerged in recent years as a novel therapy in the treatment of refractory psychiatric disease, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). Standardized outcome scales were crucial in establishing that DBS was an effective therapy for movement disorders. In order to better characterize the evidence supporting DBS for various psychiatric diseases, we performed a pooled analysis of those studies which incorporated specific standardized rating scales. A Medline search was conducted to identify all studies reporting DBS for MDD, OCD, and TS. The search yielded a total of 49 articles, of which 24 were included: 4 related to MDD (n = 48), 10 to OCD (n = 64), and 10 to TS (n = 46). A meta-analysis of DBS for MDD, OCD, and TS in studies employing disease-specific standardized outcome scales showed that the outcome scales all improved in a statistically significant fashion for these psychiatric diseases. Our pooled analysis suggests that DBS for TS has the highest efficacy amongst the psychiatric diseases currently being treated with DBS, followed by OCD and MDD. DBS for psychiatric diseases remains investigational; however, even when studies failing to incorporate standardized outcome scales are excluded, there is statistically significant evidence that DBS can improve symptoms in MDD, OCD, and TS. Standardized disease-specific outcome scales facilitate pooled analysis and should be a required metric in future studies of DBS for psychiatric disease.

  1. School performance as a precursor of adult health: exploring associations to disease-specific hospital care and their possible explanations.

    Science.gov (United States)

    Almquist, Ylva B

    2013-02-01

    While past research has shown that school performance is associated with some specific health outcomes in adulthood, few studies have taken a general approach to the link between school performance and adult disease. The aim of the present study was therefore to investigate sixth grade school performance in relation to disease-specific hospital care in adulthood and, moreover, to examine whether other conditions in childhood could account for any such associations. The data used was the Stockholm Birth Cohort, consisting of 14,294 individuals born in 1953. Associations between school performance and disease-specific hospital care were analysed by means of Cox regression. Poor school performance was shown to be linked to a variety of diseases in adulthood, e.g. drug dependence, stomach ulcer, cerebrovascular diseases, and accidents. Some differences according to gender were found. Most associations, but not all, were explained by the simultaneous inclusion of various family-related and individual factors (e.g. social class, cognitive ability, and behavioural problems). In sum, the results of this study suggest that poor school performance may be an essential part of risk clustering in childhood with important implications for the individual's health career.

  2. Comparison of clinically directed, disease specific, and syndromic protocols for the management of genital ulcer disease in Lesotho.

    Science.gov (United States)

    Htun, Y; Morse, S A; Dangor, Y; Fehler, G; Radebe, F; Trees, D L; Beck-Sague, C M; Ballard, R C

    1998-06-01

    To evaluate two protocols for the syndromic management of genital ulcer disease (GUD) in Lesotho, southern Africa and to compare the performance of these protocols with that of a conventional disease specific approach. A cross sectional study was conducted among consecutive patients with GUD attending an STD clinic in Maseru, Lesotho. The clinical diagnoses were made by using predefined criteria at the initial visit before the performance of laboratory tests. Attempts were made to detect the specific aetiology of the genital ulcers using PCR assays and syphilis serology. The results of PCR assays and syphilis serology were used as the gold standard against which the performance of the management approaches were applied. Of 100 patients initially recruited into the study, Haemophilus ducreyi infection was detected in 56%, herpes simplex virus in 26%, Treponema pallidum in 23%, and lymphogranuloma venereum in 7%. No pathogens were detected in 6% of patients. 17% of patients had mixed infections. Sensitivity, specificity, positive and negative predictive values of the three management protocols for GUD were compared after applying each to the study population. Theoretically, the lowest correct treatment rate would have been obtained by using the disease specific protocol (62%) compared with more than 90% in both syndromic management protocols. Considerable overtreatment for primary syphilis would occur following application of both syndromic protocols. This would be the result of the overdiagnosis of chancroid, in particular the misdiagnosis of genital herpes as chancroid, which would receive treatment for syphilis unnecessarily. The HIV seroprevalence among these patients was 36%. A significantly higher rate of HIV seropositivity was detected among the patients with herpes simplex virus infection when compared with those patients having other causes of genital ulcer disease (58% v 27%; odds ratio 3.73; 95% CI 1.26-11.26; p = 0.01). Poor sensitivity, specificity, and

  3. Laboratory Building

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Joshua M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    This report is an analysis of the means of egress and life safety requirements for the laboratory building. The building is located at Sandia National Laboratories (SNL) in Albuquerque, NM. The report includes a prescriptive-based analysis as well as a performance-based analysis. Following the analysis are appendices which contain maps of the laboratory building used throughout the analysis. The top of all the maps is assumed to be north.

  4. High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Sofia B Gustafsson

    Full Text Available BACKGROUND: There is good evidence in the literature that the cannabinoid system is disturbed in colorectal cancer. In the present study, we have investigated whether CB(1 receptor immunoreactive intensity (CB(1IR intensity is associated with disease severity and outcome. METHODOLOGY/PRINCIPAL FINDINGS: CB(1IR was assessed in formalin-fixed, paraffin-embedded specimens collected with a consecutive intent during primary tumour surgical resection from a series of cases diagnosed with colorectal cancer. Tumour centre (n = 483 and invasive front (n = 486 CB(1IR was scored from 0 (absent to 3 (intense staining and the data was analysed as a median split i.e. CB(1IR <2 and ≥2. In microsatellite stable, but not microsatellite instable tumours (as adjudged on the basis of immunohistochemical determination of four mismatch repair proteins, there was a significant positive association of the tumour grade with the CB(1IR intensity. The difference between the microsatellite stable and instable tumours for this association of CB(1IR was related to the CpG island methylation status of the cases. Cox proportional hazards regression analyses indicated a significant contribution of CB(1IR to disease-specific survival in the microsatellite stable tumours when adjusting for tumour stage. For the cases with stage II microsatellite stable tumours, there was a significant effect of both tumour centre and front CB(1IR upon disease specific survival. The 5 year probabilities of event-free survival were: 85±5 and 66±8%; tumour interior, 86±4% and 63±8% for the CB(1IR<2 and CB(1IR≥2 groups, respectively. CONCLUSIONS/SIGNIFICANCE: The level of CB(1 receptor expression in colorectal cancer is associated with the tumour grade in a manner dependent upon the degree of CpG hypermethylation. A high CB(1IR is indicative of a poorer prognosis in stage II microsatellite stable tumour patients.

  5. Fatigue in patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status, and sleep disturbance.

    Science.gov (United States)

    Aissaoui, N; Rostom, S; Hakkou, J; Berrada Ghziouel, K; Bahiri, R; Abouqal, R; Hajjaj-Hassouni, N

    2012-07-01

    This study aims to evaluate the frequency of fatigue in Moroccan patients with ankylosing spondylitis (AS), and its relationships with disease-specific variables, psychological status, and sleep disturbance. A cross-sectional study included patients fulfilled the modified New York classification criteria for ankylosing spondylitis. To assess fatigue, the first item of Bath ankylosing spondylitis disease activity index (BASDAI) and the multidimensional assessment of fatigue (MAF) was used. The evaluation included the activity of the disease (BASDAI), global well-being (Bath ankylosing spondylitis global index), functional status (Bath ankylosing spondylitis functional index), metrologic measurements (Bath ankylosing spondylitis metrological index), and visual analog scale of axial or joint pain. The erythrocyte sedimentation rate and C-reactive protein were measured. To assess psychological status, the hospital anxiety and depression scale (HADS) was used. Sleep disturbance was assessed by the fourth item of Hamilton anxiety scale. One hundred and ten patients were included, of average age 38.0 years ± 12.6. In our data, 66.4% experienced severe fatigue (BASDAI fatigue ≥ 5). The mean total score of MAF was 26 ± 12.77. The disease-specific variables contributed significantly with both BASDAI fatigue and MAF as dependent variables, accounting for 71.3 and 65.6% of the variance, respectively. The contribution of the depression, anxiety, and sleep disturbance were 24.9, 18.4 and 15.4%, respectively. This study state the importance of fatigue in AS patients. Even though disease activity was the most powerful predictor of fatigue, the effects of psychogenic factors and sleep disturbance, should be taken into consideration in the management of AS.

  6. A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation.

    Directory of Open Access Journals (Sweden)

    Warren D Anderson

    2017-07-01

    Full Text Available Multiple physiological systems interact throughout the development of a complex disease. Knowledge of the dynamics and connectivity of interactions across physiological systems could facilitate the prevention or mitigation of organ damage underlying complex diseases, many of which are currently refractory to available therapeutics (e.g., hypertension. We studied the regulatory interactions operating within and across organs throughout disease development by integrating in vivo analysis of gene expression dynamics with a reverse engineering approach to infer data-driven dynamic network models of multi-organ gene regulatory influences. We obtained experimental data on the expression of 22 genes across five organs, over a time span that encompassed the development of autonomic nervous system dysfunction and hypertension. We pursued a unique approach for identification of continuous-time models that jointly described the dynamics and structure of multi-organ networks by estimating a sparse subset of ∼12,000 possible gene regulatory interactions. Our analyses revealed that an autonomic dysfunction-specific multi-organ sequence of gene expression activation patterns was associated with a distinct gene regulatory network. We analyzed the model structures for adaptation motifs, and identified disease-specific network motifs involving genes that exhibited aberrant temporal dynamics. Bioinformatic analyses identified disease-specific single nucleotide variants within or near transcription factor binding sites upstream of key genes implicated in maintaining physiological homeostasis. Our approach illustrates a novel framework for investigating the pathogenesis through model-based analysis of multi-organ system dynamics and network properties. Our results yielded novel candidate molecular targets driving the development of cardiovascular disease, metabolic syndrome, and immune dysfunction.

  7. High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer.

    Science.gov (United States)

    Gustafsson, Sofia B; Palmqvist, Richard; Henriksson, Maria L; Dahlin, Anna M; Edin, Sofia; Jacobsson, Stig O P; Öberg, Åke; Fowler, Christopher J

    2011-01-01

    There is good evidence in the literature that the cannabinoid system is disturbed in colorectal cancer. In the present study, we have investigated whether CB(1) receptor immunoreactive intensity (CB(1)IR intensity) is associated with disease severity and outcome. CB(1)IR was assessed in formalin-fixed, paraffin-embedded specimens collected with a consecutive intent during primary tumour surgical resection from a series of cases diagnosed with colorectal cancer. Tumour centre (n = 483) and invasive front (n = 486) CB(1)IR was scored from 0 (absent) to 3 (intense staining) and the data was analysed as a median split i.e. CB(1)IR microsatellite stable, but not microsatellite instable tumours (as adjudged on the basis of immunohistochemical determination of four mismatch repair proteins), there was a significant positive association of the tumour grade with the CB(1)IR intensity. The difference between the microsatellite stable and instable tumours for this association of CB(1)IR was related to the CpG island methylation status of the cases. Cox proportional hazards regression analyses indicated a significant contribution of CB(1)IR to disease-specific survival in the microsatellite stable tumours when adjusting for tumour stage. For the cases with stage II microsatellite stable tumours, there was a significant effect of both tumour centre and front CB(1)IR upon disease specific survival. The 5 year probabilities of event-free survival were: 85±5 and 66±8%; tumour interior, 86±4% and 63±8% for the CB(1)IRcolorectal cancer is associated with the tumour grade in a manner dependent upon the degree of CpG hypermethylation. A high CB(1)IR is indicative of a poorer prognosis in stage II microsatellite stable tumour patients.

  8. Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population

    Science.gov (United States)

    Liu, Xiao-Lin; Pan, Qin; Zhang, Rui-Nan; Shen, Feng; Yan, Shi-Yan; Sun, Chao; Xu, Zheng-Jie; Chen, Yuan-Wen; Fan, Jian-Gao

    2016-01-01

    AIM To assess disease-specific circulating microRNAs (miRNAs) in non-alcoholic steatohepatitis (NASH) patients. METHODS A total of 111 biopsy-proven non-alcoholic fatty liver disease (NAFLD) or chronic hepatitis B (CHB) patients and healthy controls from mainland China were enrolled to measure their serum levels of miR-122, -125b, -146b, -16, -21, -192, -27b and -34a. The correlations between serum miRNAs and histological features of NAFLD were determined. The diagnostic value of miRNA in NASH and significant fibrosis was analyzed and compared with that of cytokeratin-18 (CK-18), fibrosis-4 (FIB-4), and aspartate aminotransferase to platelet ratio index (APRI), respectively. RESULTS Circulating miR-122, -16, -192 and -34a showed differential expression levels between NAFLD and CHB patients, and miR-34a had an approximately 2-fold increase in NAFLD samples compared with that of CHB samples (P < 0.01). Serum miR-122, -192 and -34a levels were correlated with steatosis (R = 0.302, 0.323 and 0.470, respectively, P < 0.05) and inflammatory activity (R = 0.445, 0.447 and 0.517, respectively, P < 0.01); only serum miR-16 levels were associated with fibrosis (R = 0.350, P < 0.05) in patients with NAFLD. The diagnostic value of miR-34a for NASH (area under the receiver operating characteristic, 0.811, 95%CI: 0.670-0.953) was superior to that of alanine aminotransferase, CK-18, FIB-4 and APRI in NAFLD, but miR-16 showed a limited performance in the diagnosis of significant fibrosis in NASH. CONCLUSION Circulating miR-34a may serve as a disease-specific noninvasive biomarker for the diagnosis of NASH. PMID:27956809

  9. Disease-specific quality of life after septoplasty and bilateral inferior turbinate outfracture in patients with nasal obstruction.

    Science.gov (United States)

    Resende, Lucas; Carmo, Carolina do; Mocellin, Leão; Pasinato, Rogério; Mocellin, Marcos

    2017-07-29

    Septal deviations might cause nasal obstruction and negative impact on the quality of life of individuals. The efficacy of septoplasty for treatment of septal deviation and the predictors of satisfactory surgical outcomes remain controversial. Technical variability, heterogeneity of research samples and absence of a solid tool for clinical evaluation are the main hindrances to the establishment of reliable statistical data regarding the procedure. To evaluate the clinical improvements in the disease-specific quality-of-life between patients submitted to septoplasty with bilateral outfracture of the inferior turbinate under sedation and local anesthesia in a tertiary hospital and to assess possible clinical-epidemiological variables associated with functional outcome. Fifty-two patients consecutively submitted to septoplasty with bilateral outfracture of the inferior turbinate for treatment of nasal obstruction filled in forms regarding clinical and epidemiological information during enrollment and had their symptom objectively quantified using the Nose Obstruction Symptom Evaluation (NOSE) scale preoperatively and one and three months after the procedure. Statistical analysis aimed to determine overall and stratified surgical outcomes and to investigate correlations between the clinical-epidemiological variables with the scores obtained. Statistically significant improvement in the preoperative NOSE questionnaire compared to the scores obtained three months after surgery was demonstrated (p0.05). Gender, age, history of rhinitis and presence of pulmonary comorbidity did not influence significantly surgical outcomes (p>0.05). Smokers presented greater reduction in NOSE scores during the study (p=0.043, U-Mann-Whitney). Septoplasty with bilateral outfracture of the inferior turbinate has proven to significantly improve disease-specific quality-of-life and this favorable outcome seems to occur precociously. Copyright © 2017 Associação Brasileira de

  10. Building sustainability

    CSIR Research Space (South Africa)

    Mass Media

    2007-11-01

    Full Text Available proactive,” Van Wyk says. “Demand for greener buildings is slowly beginning to increase among tenants. If asset managers do not take action, the value of assets will depreciate rapidly, and this will make the building obsolete within five years...

  11. On-column entrapment of alpha1-acid glycoprotein for studies of drug-protein binding by high-performance affinity chromatography.

    Science.gov (United States)

    Anguizola, Jeanethe; Bi, Cong; Koke, Michelle; Jackson, Abby; Hage, David S

    2016-08-01

    An on-column approach for protein entrapment was developed to immobilize alpha1-acid glycoprotein (AGP) for drug-protein binding studies based on high-performance affinity chromatography. Soluble AGP was physically entrapped by using microcolumns that contained hydrazide-activated porous silica and by employing mildly oxidized glycogen as a capping agent. Three on-column entrapment methods were evaluated and compared to a previous slurry-based entrapment method. The final selected method was used to prepare 1.0 cm × 2.1 mm I.D. affinity microcolumns that contained up to 21 (±4) μg AGP and that could be used over the course of more than 150 sample applications. Frontal analysis and zonal elution studies were performed on these affinity microcolumns to examine the binding of various drugs with the entrapped AGP. Site-selective competition studies were also conducted for these drugs. The results showed good agreement with previous observations for these drug-protein systems and with binding constants that have been reported in the literature. The entrapment method developed in this study should be useful for future work in the area of personalized medicine and in the high-throughput screening of drug interactions with AGP or other proteins. Graphical abstract On-column protein entrapment using a hydrazide-activated support and oxidized glycogen as a capping agent.

  12. Development and Validation of a Disease-Specific Questionnaire to Assess Patient-Reported Symptoms in Polycystic Liver Disease.

    Science.gov (United States)

    Neijenhuis, Myrte K; Gevers, Tom J G; Hogan, Marie C; Kamath, Patrick S; Wijnands, Titus F M; van den Ouweland, Ralf C P M; Edwards, Marie E; Sloan, Jeff A; Kievit, Wietske; Drenth, Joost P H

    2016-07-01

    Treatment of polycystic liver disease (PLD) focuses on symptom improvement. Generic questionnaires lack sensitivity to capture PLD-related symptoms, a prerequisite to determine effectiveness of therapy. We developed and validated a disease-specific questionnaire that assesses symptoms in PLD (PLD-Q). We identified 16 PLD-related symptoms (total score 0-100 points) by literature review and interviews with patients and clinicians. The developed PLD-Q was validated in Dutch (n = 200) and United States (US; n = 203) PLD patients. We assessed the correlation of PLD-Q total score with European Organization for Research and Treatment of Cancer (EORTC) symptom scale, global health visual analogue scale (VAS) of EQ-5D, and liver volume. To test discriminative validity, we compared PLD-Q total scores of patients with different PLD severity stages (Gigot classification) and PLD-Q total scores of PLD patients with general controls and polycystic kidney disease patients without PLD. Reproducibility was tested by comparing original test scores with 2-week retest scores. In total, 167 Dutch and 124 US patients returned the questionnaire. Correlation between PLD-Q total score and EORTC symptom scale (The Netherlands [NL], r = 0.788; US, r = 0.811) and global health VAS (NL, r = -0.517; US, r = -0.593) was good. There was no correlation of PLD-Q total score with liver volume (NL, r = 0.138; P = 0.236; US, r = 0.254; P = 0.052). Gigot type III individuals scored numerically higher than type II patients (NL, 46 vs. 40; P = 0.089; US, 48 vs. 36; P = 0.055). PLD patients scored higher on the PLD-Q total score than general controls (NL, 42 vs. 17; US, 40 vs. 13 points) and polycystic kidney disease patients without PLD (22 points). Reproducibility of PLD-Q was excellent (NL, r = 0.94; US, 0.96). PLD-Q is a valid, reproducible, and sensitive disease-specific questionnaire that can be used to assess PLD-related symptoms in clinical care and future research. (Hepatology 2016;64:151-160).

  13. Discriminative and predictive properties of disease-specific and generic health status indexes in elderly COPD patients

    Directory of Open Access Journals (Sweden)

    Forastiere Francesco

    2008-08-01

    Full Text Available Abstract Background The association between bronchial obstruction severity and mortality in Chronic Obstructive Pulmonary Disease (COPD is well established, but it is unknown whether disease-specific health status measures and multidimensional assessment (MDA have comparable prognostic value. Methods We analyzed data coming from the Salute Respiratoria nell'Anziano (Respiratory Health in the Elderly – SaRA study, enrolling elderly people attending outpatient clinics for respiratory and non-respiratory problems. From this population we selected 449 patients with bronchial obstruction (77.3% men, mean age 73.1. We classified patients' health status using tertiles of the Saint George Respiratory Questionnaire (SGRQ and a MDA including functional (the 6' walking test, WT, cognitive (Mini-Mental State Examination, MMSE and affective status (Geriatric Depression Scale, GDS. The agreement of the classification methods was calculated using the kappa statistic, and survival associated with group membership was evaluated using survival analysis. Results Pulmonary function, expressed by the FEV1, worsened with increasing SGRQ or MDA scores. Cognitive function was not associated with the SGRQ, while physical performance and mood status were impaired only in the highest tertile of SGRQ. A poor agreement was found between the two classification systems tested (k = 0.194. Compared to people in the first tertile of SGRQ score, those in the second tertile had a sex-adjusted HR of 1.22 (0.75 – 1.98 and those in the third tertile of 2.90 (1.92 – 4.40. The corresponding figures of the MDA were 1.49 (95% CI 1.02 – 2.18 and 2.01 (95% CI: 1.31 – 3.08. After adjustment for severity of obstruction, only a SGRQ in the upper tertile was associated with mortality (HR: 1.86; 95% CI: 1.14 – 3.02. Conclusion In elderly outpatients with mild-moderate COPD, a disease-specific health status index seems to be a better predictor of death compared to a MDA.

  14. Building Data

    Data.gov (United States)

    Town of Cary, North Carolina — Explore real estate information about buildings in the Town of Cary.This file is created by the Town of Cary GIS Group. It contains data from both the Wake, Chatham...

  15. Quality of life after traumatic brain injury: the clinical use of the QOLIBRI, a novel disease-specific instrument.

    Science.gov (United States)

    Truelle, Jean-Luc; Koskinen, Sanna; Hawthorne, Graeme; Sarajuuri, Jaana; Formisano, Rita; Von Wild, Klaus; Neugebauer, Edmund; Wilson, Lindsay; Gibbons, Henning; Powell, Jane; Bullinger, Monika; Höfer, Stefan; Maas, Andrew; Zitnay, George; Von Steinbuechel, Nicole

    2010-01-01

    To report the clinical use of the QOLIBRI, a disease-specific measure of health-related quality-of-life (HRQoL) after traumatic brain injury (TBI). The QOLIBRI, with 37 items in six scales (cognition, self, daily life and autonomy, social relationships, emotions and physical problems) was completed by 795 patients in six languages (Finnish, German, Italian, French, English and Dutch). QOLIBRI scores were examined by variables likely to be influenced by rehabilitation interventions and included socio-demographic, functional outcome, health status and mental health variables. The QOLIBRI was self-completed by 73% of participants and 27% completed it in interview. It was sensitive to areas of life amenable to intervention, such as accommodation, work participation, health status (including mental health) and functional outcome. The QOLIBRI provides information about patient's subjective perception of his/her HRQoL which supplements clinical measures and measures of functional outcome. It can be applied across different populations and cultures. It allows the identification of personal needs, the prioritization of therapeutic goals and the evaluation of individual progress. It may also be useful in clinical trials and in longitudinal studies of TBI recovery.

  16. Social Media and Myeloproliferative Neoplasms (MPN)--Focus on Twitter and the Development of a Disease-specific Community: #MPNSM.

    Science.gov (United States)

    Pemmaraju, Naveen; Gupta, Vikas; Mesa, Ruben; Thompson, Michael A

    2015-12-01

    The advent of social media has led to the ability for individuals all over the world to communicate with each other, in real time, about mutual topics of interest in an unprecedented manner. Recently, the use of social media has increased among people interested in healthcare and medical research, particularly in the field of hematology and oncology, a field which frequently experiences rapid shifts of information and novel, practice-changing discoveries. Among the many social media platforms available to cancer patients and providers, one platform in particular, Twitter, has become the focus for the creation of disease-specific communities, especially for those interested in, affected by, or those who perform research in the fields of rare cancers, which historically have had a dearth of reliable information available. This article will focus on the initiation and progress of one such Twitter hematology/oncology community, #mpnsm, which was originally created for the purpose of serving as a venue for improving the interaction among patients, providers, researchers, and organizations with interest in the myeloproliferative neoplasms (MPNs) and to further the availability of reliable up-to-date analysis; relevant expert commentary; and readily usable information for patients, providers, and other groups interested in this field.

  17. Serum Metabolomics to Identify the Liver Disease-Specific Biomarkers for the Progression of Hepatitis to Hepatocellular Carcinoma

    Science.gov (United States)

    Gao, Rong; Cheng, Jianhua; Fan, Chunlei; Shi, Xiaofeng; Cao, Yuan; Sun, Bo; Ding, Huiguo; Hu, Chengjin; Dong, Fangting; Yan, Xianzhong

    2015-12-01

    Hepatocellular carcinoma (HCC) is a common malignancy that has region specific etiologies. Unfortunately, 85% of cases of HCC are diagnosed at an advanced stage. Reliable biomarkers for the early diagnosis of HCC are urgently required to reduced mortality and therapeutic expenditure. We established a non-targeted gas chromatography-time of flight-mass spectrometry (GC-TOFMS) metabolomics method in conjunction with Random Forests (RF) analysis based on 201 serum samples from healthy controls (NC), hepatitis B virus (HBV), liver cirrhosis (LC) and HCC patients to explore the metabolic characteristics in the progression of hepatocellular carcinogenesis. Ultimately, 15 metabolites were identified intimately associated with the process. Phenylalanine, malic acid and 5-methoxytryptamine for HBV vs. NC, palmitic acid for LC vs. HBV, and asparagine and β-glutamate for HCC vs. LC were screened as the liver disease-specific potential biomarkers with an excellent discriminant performance. All the metabolic perturbations in these liver diseases are associated with pathways for energy metabolism, macromolecular synthesis, and maintaining the redox balance to protect tumor cells from oxidative stress.

  18. "Dualities of interest": the inter-organizational relationships between disease-specific nonprofits and the pharmaceutical industry.

    Science.gov (United States)

    Paluzzi, Joan E

    2012-01-01

    Health care and biomedical research environments in the United States are largely characterized by strategic relational practices conducted beyond the public gaze. The very nature of health care has been widely reconceptualized from a response to physical/biological imperatives regulated by health promotion and the epidemiological distribution of diseases to profit/market imperatives regulated by "product/brand" promotion and market dynamics. At critical decision points throughout the system, we find the multinational pharmaceutical industry wielding the influence that its wealth and power have bought. This study contributes to the growing body of work that seeks to illuminate the relationships between the pharmaceutical industry and the various entities that constitute the U.S. health and research systems. Through the use of case studies, it examines the relationships between the multinational pharmaceutical industry and the large disease-specific public and professional nonprofit organizations. It explores several questions, including: Is the concept of what constitutes a conflict of interest being purposefully manipulated? Is the public benevolence afforded to nonprofits extended to their corporate partners in ways that preclude critical oversight of relational dynamics? And are public donations, solicited by and given in good faith to these organizations, inevitably serving the economic interests and profits of donor pharmaceutical companies?

  19. Sustainable Buildings

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Elle, Morten

    The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems that ...... that need urgent action. The built environment is an obvious area to put effort into because of the large and cost-effective energy saving potential and potential for Renewable Energy-based supply systems for buildings.......The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems...

  20. Building Procurement

    DEFF Research Database (Denmark)

    Andersson, Niclas

    2007-01-01

    ‘The procurement of construction work is complex, and a successful outcome frequently elusive’. With this opening phrase of the book, the authors take on the challenging job of explaining the complexity of building procurement. Even though building procurement systems are, and will remain, complex...... despite this excellent book, the knowledge, expertise, well-articulated argument and collection of recent research efforts that are provided by the three authors will help to make project success less elusive. The book constitutes a thorough and comprehensive investigation of building procurement, which...... evolves from a simple establishment of a contractual relationship to a central and strategic part of construction. The authors relate to cultural, ethical and social and behavioural sciences as the fundamental basis for analysis and understanding of the complexity and dynamics of the procurement system...

  1. DrugLogit: logistic discrimination between drugs and nondrugs including disease-specificity by assigning probabilities based on molecular properties.

    Science.gov (United States)

    García-Sosa, Alfonso T; Oja, Mare; Hetényi, Csaba; Maran, Uko

    2012-08-27

    The increasing knowledge of both structure and activity of compounds provides a good basis for enhancing the pharmacological characterization of chemical libraries. In addition, pharmacology can be seen as incorporating both advances from molecular biology as well as chemical sciences, with innovative insight provided from studying target-ligand data from a ligand molecular point of view. Predictions and profiling of libraries of drug candidates have previously focused mainly on certain cases of oral bioavailability. Inclusion of other administration routes and disease-specificity would improve the precision of drug profiling. In this work, recent data are extended, and a probability-based approach is introduced for quantitative and gradual classification of compounds into categories of drugs/nondrugs, as well as for disease- or organ-specificity. Using experimental data of over 1067 compounds and multivariate logistic regressions, the classification shows good performance in training and independent test cases. The regressions have high statistical significance in terms of the robustness of coefficients and 95% confidence intervals provided by a 1000-fold bootstrapping resampling. Besides their good predictive power, the classification functions remain chemically interpretable, containing only one to five variables in total, and the physicochemical terms involved can be easily calculated. The present approach is useful for an improved description and filtering of compound libraries. It can also be applied sequentially or in combinations of filters, as well as adapted to particular use cases. The scores and equations may be able to suggest possible routes for compound or library modification. The data is made available for reuse by others, and the equations are freely accessible at http://hermes.chem.ut.ee/~alfx/druglogit.html.

  2. Validation of a Chinese version of disease specific quality of life scale (HFS-36) for hemifacial spasm in Taiwan

    Science.gov (United States)

    2009-01-01

    Background and object There was no Chinese questionnaire to evaluate the health-related quality of life (HRQoL) in patients with hemifacial spasm (HFS). In this study, we aimed to validate a new disease-specific HRQoL scale for HFS (HFS-36) in Chinese version, and compared it to SF-36, a generic HRQoL scale. Patients and Methods The HFS-36 Chinese version was modified from English version of HFS-30, including subscales of mobility, activities of daily living (ADL), emotional well-being, stigma, social support, cognition, bodily discomfort, and communication. All the items were scored on the 5-point scales, ranging from 0(never) to 4(always). Patients with HFS were asked to answer HFS-36 and SF-36 questionnaires on the same day before and 6-8 weeks after Botulinum toxin (BTX) injections, respectively. The reliability and validity of HFS-36 scale were evaluated statistically. Results Totally, 103 patients (68 females; 35 males) were recruited in this study, with a mean age of 57.6 ± 11.5 years and a mean duration of HFS for 7.6 ± 5.8 years. The intra-class correlation (ICC) and Cronbach's α were over 0.7 in the majority of items. HFS-36 showed a good correlation to HFS severity before BTX treatment and a significant improvement of subscale scoring after BTX treatment. HFS-36 also had a significant correlation to the mental health of SF-36. Conclusions The Chinese version of HFS-36 demonstrated a good reliability and validity in subscales of motility, ADL, emotion well-being, stigma and bodily discomfort. The HRQoL was significantly improved after BTX treatment assessed by HFS-36 or SF-36. Compared to SF-36, HFS-36 scale was more sensitive and specific to evaluate the HRQoL in HFS. PMID:20034399

  3. Validation of a Chinese version of disease specific quality of life scale (HFS-36 for hemifacial spasm in Taiwan

    Directory of Open Access Journals (Sweden)

    Chang Hong-Shiu

    2009-12-01

    Full Text Available Abstract Background and object There was no Chinese questionnaire to evaluate the health-related quality of life (HRQoL in patients with hemifacial spasm (HFS. In this study, we aimed to validate a new disease-specific HRQoL scale for HFS (HFS-36 in Chinese version, and compared it to SF-36, a generic HRQoL scale. Patients and Methods The HFS-36 Chinese version was modified from English version of HFS-30, including subscales of mobility, activities of daily living (ADL, emotional well-being, stigma, social support, cognition, bodily discomfort, and communication. All the items were scored on the 5-point scales, ranging from 0(never to 4(always. Patients with HFS were asked to answer HFS-36 and SF-36 questionnaires on the same day before and 6-8 weeks after Botulinum toxin (BTX injections, respectively. The reliability and validity of HFS-36 scale were evaluated statistically. Results Totally, 103 patients (68 females; 35 males were recruited in this study, with a mean age of 57.6 ± 11.5 years and a mean duration of HFS for 7.6 ± 5.8 years. The intra-class correlation (ICC and Cronbach's α were over 0.7 in the majority of items. HFS-36 showed a good correlation to HFS severity before BTX treatment and a significant improvement of subscale scoring after BTX treatment. HFS-36 also had a significant correlation to the mental health of SF-36. Conclusions The Chinese version of HFS-36 demonstrated a good reliability and validity in subscales of motility, ADL, emotion well-being, stigma and bodily discomfort. The HRQoL was significantly improved after BTX treatment assessed by HFS-36 or SF-36. Compared to SF-36, HFS-36 scale was more sensitive and specific to evaluate the HRQoL in HFS.

  4. Disease-specific survival in de novo metastatic renal cell carcinoma in the cytokine and targeted therapy era.

    Science.gov (United States)

    Pal, Sumanta K; Nelson, Rebecca A; Vogelzang, Nicholas

    2013-01-01

    Recent phase III studies of targeted agents for metastatic renal cell carcinoma (mRCC) have generated median survival estimates that far exceed those observed during the cytokine era. However, substantial population-based data does not exist to confirm this trend. We sought to determine whether survival has improved for patients with mRCC diagnosed in the era of targeted therapies, as compared to the era of immunotherapy. The Surveillance, Epidemiology, and End Results (SEER) Registry was used to identify patients aged 18 and older diagnosed stage IV RCC between 1992 and 2009. Patients had documented clear cell, papillary or chromophobe histology. The Kaplan Meier method and log-rank test were used to compare disease-specific survival (DSS) for patients diagnosed from 1992-2004 (i.e., the cytokine era) and 2005-2009 (i.e., the targeted therapy era). Univariate and multivariate analyses of relevant clinicopathologic characteristics were also performed. Of 5,176 patients identified using the above characteristics, 2,392 patients were diagnosed from 1992-2004 and 2,784 from 2005-2009. Median DSS was improved in those patients diagnosed from 2005-2009 (16 months vs 13 months; Pcell (P = 0.0006), but not in patients with non-clear cell disease (P = 0.32). Notable findings on multivariate analysis include an association between shorter DSS and the following characteristics: (1) diagnosis from 1992-2004, (2) advanced age (80+), and (3) absence of cytoreductive nephrectomy. These data reflect progress in the management of mRCC, specifically in the era of targeted therapies. Notably, it was inferred that certain treatment strategies were employed during pre-specified time periods, representing a major caveat of the current analysis. Further studies related to the influence of age and race/ethnicity are warranted, as are studies exploring the role of cytoreductive nephrectomy and novel treatments for non-clear cell disease.

  5. Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

    Directory of Open Access Journals (Sweden)

    Mario U Manto

    2015-03-01

    Full Text Available Autoantibodies to the smaller isoform of glutamate decarboxylase can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis. The detection of disease-specific autoantibody epitopes led to the hypothesis that distinct glutamate decarboxylase autoantibodies may elicit specific neurological phenotypes. We explored the in vitro/in vivo effects of well-characterized monoclonal glutamate decarboxylase antibodies. We found that glutamate decarboxylase autoantibodies present in patients with stiff person syndrome (n = 7 and cerebellar ataxia (n = 15 recognized an epitope distinct from that recognized by glutamate decarboxylase autoantibodies present in patients with type 1 diabetes mellitus (n = 10 or limbic encephalitis (n = 4. We demonstrated that the administration of a monoclonal glutamate decarboxylase antibody representing this epitope specificity (1 disrupted in vitro the association of glutamate decarboxylase with γ-Aminobutyric acid containing synaptic vesicles, (2 depressed the inhibitory synaptic transmission in cerebellar slices with a gradual time course and a lasting suppressive effect, (3 significantly decreased conditioned eyelid responses evoked in mice, with no modification of learning curves in the classical eyeblink-conditioning task, (4 markedly impaired the facilitatory effect exerted by the premotor cortex over the motor cortex in a paired-pulse stimulation paradigm, and (5 induced decreased exploratory behavior and impaired locomotor function in rats. These findings support the specific targeting of glutamate decarboxylase by its autoantibodies in the pathogenesis of stiff-person syndrome and cerebellar ataxia. Therapies of these disorders based on selective removal of such glutamate decarboxylase antibodies could be envisioned.

  6. Morbid obesity as an independent risk factor for disease-specific mortality in women with cervical cancer.

    Science.gov (United States)

    Frumovitz, Michael; Jhingran, Anuja; Soliman, Pamela T; Klopp, Ann H; Schmeler, Kathleen M; Eifel, Patricia J

    2014-12-01

    To assess whether obesity is an independent predictor of mortality in women with cervical cancer. This retrospective cohort study of patients with stages IB1-IVA cervical cancer treated with curative intent at MD Anderson Cancer Center from 1980 through 2007 categorized these women as underweight, normal weight, overweight, obese, or morbidly obese according to National Institutes of Health definitions. In addition to weight category, known prognostic factors for survival after a diagnosis of cervical cancer were included in a multivariate model. These known prognostic factors included age, smoking status, race or ethnicity (self-reported), socioeconomic status, comorbidities, tumor histologic subtype, tumor stage, tumor size, presence or absence of hydronephrosis, radiologic evidence of nodal metastasis, and the addition of concurrent chemotherapy with definitive radiation. A total of 3,086 patients met the inclusion criteria. The median survival for the entire cohort was 81 months (range 0-365 months). The presence of lymph node spread and advancing stage were the most significant predictors of survival. Compared with normal-weight women, morbidly obese women had a significantly higher hazard ratio for both all-cause death (hazard ratio 1.26, 95% confidence interval [CI] 1.10-1.45) and disease-specific death (hazard ratio 1.24, 95% CI 1.06-1.47). Underweight, overweight, and obese women did not have an increased risk for death compared with normal-weight women. After controlling for all previously known prognostic factors, morbid obesity remains an independent risk factor for death from cervical cancer. Overweight and obese women have the same prognosis as normal-weight women.

  7. Melanoma patients' disease-specific knowledge, information preference, and appreciation of educational YouTube videos for self-inspection.

    Science.gov (United States)

    Damude, S; Hoekstra-Weebers, J E H M; van Leeuwen, B L; Hoekstra, H J

    2017-08-01

    Informing and educating melanoma patients is important for early detection of a recurrence or second primary. This study aimed to investigate Dutch melanoma patients' disease-specific knowledge, and their opinions on information provision and the value of e-Health videos. All AJCC stage I-II melanoma patients in follow-up between March 2015 and March 2016 at a single melanoma center were invited to complete 19 online questions, addressing respondents' characteristics, knowledge on melanoma, and opinions on melanoma-specific information received and the educational YouTube videos. In total, 100 patients completed the survey (response = 52%); median age was 60 years and 51% were female. Breslow tumor thickness was unknown by 34% and incorrectly indicated by 19%, for presence of ulceration this was 33% and 11%, for mitosis 65% and 14%, and for AJCC stage 52% and 23%, respectively. Only 5% correctly reproduced all four tumor characteristics. Orally delivered information regarding warning signs, severity, treatment possibilities, and importance of self-inspection was clearest for patients, compared to information in the melanoma brochure. According to 77% of patients, YouTube videos regarding self-inspection of the skin and regional lymph nodes had additional value. Altogether, 63% preferred receiving information in multiple ways; 92% orally by their physician, 62% through videos, and 43% through brochures. Patients' melanoma-specific knowledge appears to be limited. There is an urgent need for further improvement of providing information and patient education. In addition to oral and written information, e-Health videos seem to be a convenient supplemental and easy accessible method for patient education. Copyright © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

  8. Comparing effectiveness of generic and disease-specific self-management interventions for people with diabetes in a practice context.

    Science.gov (United States)

    Ghahari, Setareh; Packer, Tanya; Boldy, Duncan; Melling, Lauren; Parsons, Richard

    2015-10-01

    The effectiveness of self-management interventions has been demonstrated. However, the benefits of generic vs. disease-specific programs are unclear, and their efficacy within a practice setting has yet to be fully explored. To compare the outcomes of the diabetes-specific self-management program (Diabetes) and the generic chronic disease Self-management Program (Chronic Condition) and to explore whether program characteristics, evaluated using the Quality Self-Management Assessment Framework (Q-SAF), provide insight into the results of the outcome evaluation. A pragmatic pretest, post-test design with 12-week follow up was used to compare the 2 self-management interventions. Outcomes were quality of life, self-efficacy, loneliness, self-management skills, depression, and health behaviours. People with diabetes self-selected attendance at the Diabetes or Chronic Condition program offered as part of routine practice. Participants with diabetes in the 2 programs (Diabetes=200; Chronic Condition=90) differed significantly in almost all demographic and clinical characteristics. Both programs yielded positive outcomes. Controlling for baseline and demographic characteristics, random effects modelling showed an interaction between time and program for 1 outcome: self-efficacy (p=0.029). Participants in the Chronic Condition group experienced greater improvements over time than did those in the Diabetes group. The Q-SAF analysis showed differences in program content, delivery and workforce capacity. People with diabetes benefited from both programs, but participation in the generic program resulted in greater improvements in self-efficacy for participants who had self-selected that program. Both programs in routine care led to health-related improvements. The Q-SAF can be used to assess the quality of programs. Copyright © 2015 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

  9. Validation of the Disease-specific Questionnaire MSQoL-54 in Bosnia and Herzegovina Multiple Sclerosis Patients Sample.

    Science.gov (United States)

    Catic, Tarik; Culig, Josip; Suljic, Enra; Masic, Admir; Gojak, Refet

    2017-04-01

    The purpose of this study was to validate Bosnian translation of disease specific quality of life measure MSQoL-54 which is widely used in practice. Previously translated and culturally adopted MSQoL-54 questionnaire used in this study has been provided and licensed by Optum Inc. The questionnaire was validated in 62 MS patients seen at Neurology clinic at University Clinical Center Sarajevo, during April 2016 until May 2016. Internal reliabilities of Bosnian version MSQoL-54 were assessed for multiple item scales by using Cronbach's alpha coefficient. Clinical validity was assessed comparing means of the two summary MSQoL-54 scores by the EDSS score. Pearson's (r) correlation coefficient was used to investigate the relationship between the composite scores and the main clinical and demographic variables. Patients' participation was satisfactory and all scales fulfilled the usual psychometric standards. Highly significant inverse relationship was found between both composite scores and clinical characteristics of the disease and the EDSS. The lowest internal consistency reliability is found on social function scale (0.743), overall quality of life (0.782) and pain (0.833). The highest internal consistency reliability is found on role limitations due to physical problems (0.959), physical health (0.962) and role limitations due to emotional problems (0.966). The mean value of MSQoL-54 PHC (Physical Health Composite) and MHC (Mental Health Composite) were 49.82±18.90 (36.05-61.38) 51.84±22.22 (34.93-70.20) respectively. Our study has shown that the Bosnian version of MSQoL-54 is easy to administer and well accepted by patients and may be useful as clinical outcome measures in patients with MS.

  10. Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.

    Science.gov (United States)

    Herbert, Megan K; Stammen-Vogelzangs, Judith; Verbeek, Marcel M; Rietveld, Anke; Lundberg, Ingrid E; Chinoy, Hector; Lamb, Janine A; Cooper, Robert G; Roberts, Mark; Badrising, Umesh A; De Bleecker, Jan L; Machado, Pedro M; Hanna, Michael G; Plestilova, Lenka; Vencovsky, Jiri; van Engelen, Baziel G; Pruijn, Ger J M

    2016-04-01

    The diagnosis of inclusion body myositis (IBM) can be challenging as it can be difficult to clinically distinguish from other forms of myositis, particularly polymyositis (PM). Recent studies have shown frequent presence of autoantibodies directed against cytosolic 5'-nucleotidase 1A (cN-1A) in patients with IBM. We therefore, examined the autoantigenicity and disease specificity of major epitopes of cN-1A in patients with sporadic IBM compared with healthy and disease controls. Serum samples obtained from patients with IBM (n=238), PM and dermatomyositis (DM) (n=185), other autoimmune diseases (n=246), other neuromuscular diseases (n=93) and healthy controls (n=35) were analysed for the presence of autoantibodies using immunodominant cN-1A peptide ELISAs. Autoantibodies directed against major epitopes of cN-1A were frequent in patients with IBM (37%) but not in PM, DM or non-autoimmune neuromuscular diseases (autoimmune diseases, particularly Sjögren's syndrome (SjS; 36%) and systemic lupus erythematosus (SLE; 20%). In summary, we found frequent anti-cN-1A autoantibodies in sera from patients with IBM. Heterogeneity in reactivity with the three immunodominant epitopes indicates that serological assays should not be limited to a distinct epitope region. The similar reactivities observed for SjS and SLE demonstrate the need to further investigate whether distinct IBM-specific epitopes exist. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. Analysis of Drug-Protein Binding using On-Line Immunoextraction and High-Performance Affinity Microcolumns: Studies with Normal and Glycated Human Serum Albumin

    Science.gov (United States)

    Matsuda, Ryan; Jobe, Donald; Beyersdorf, Jared; Hage, David S.

    2015-01-01

    A method combining on-line immunoextraction microcolumns with high-performance affinity chromatography (HPAC) was developed and tested for use in examining drug-protein interactions with normal or modified proteins. Normal human serum albumin (HSA) and glycated HSA were used as model proteins for this work. High-performance immunoextraction microcolumns with sizes of 1.0–2.0 cm × 2.1 mm i.d. and containing anti-HSA polyclonal antibodies were developed and tested for their ability to bind normal HSA or glycated HSA. These microcolumns were able to extract up to 82–93% for either type of protein at 0.05–0.10 mL/min and had a binding capacity of 0.34–0.42 nmol HSA for a 1.0 cm × 2.1 mm i.d. microcolumn. The immunoextraction microcolumns and their adsorbed proteins were tested for use in various approaches for drug binding studies. Frontal analysis was used with the adsorbed HSA/glycated HSA to measure the overall affinities of these proteins for the drugs warfarin and gliclazide, giving comparable values to those obtained previously using similar protein preparations that had been covalently immobilized within HPAC columns. Zonal elution competition studies with gliclazide were next performed to examine the specific interactions of this drug at Sudlow sites I and II of the adsorbed proteins. These results were also comparable to those noted in prior work with covalently immobilized samples of normal HSA or glycated HSA. These experiments indicated that drug-protein binding studies can be carried out by using on-line immunoextraction microcolumns with HPAC. The same method could be used in the future with clinical samples and other drugs or proteins of interest in pharmaceutical studies or biomedical research. PMID:26381571

  12. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...... in the Media”, “Audience Interactivity and Participation”, “The Role of Media and ICT Use for Evolving Social Relationships” and “Audience Transformations and Social Integration”. Building Bridges is the result of an ongoing dialogue between the Action and non-academic stakeholders in the field of audience...

  13. Competence Building

    DEFF Research Database (Denmark)

    Borrás, Susana; Edquist, Charles

    on the one hand, and the real world of innovation policy-making on the other, typically not speaking to each other. With this purpose in mind, this paper discusses the role of competences and competence-building in the innovation process from a perspective of innovation systems; it examines how governments...... and public agencies in different countries and different times have actually approached the issue of building, maintaining and using competences in their innovation systems; it examines what are the critical and most important issues at stake from the point of view of innovation policy, looking particularly...

  14. Structure Building

    NARCIS (Netherlands)

    Odijk, J.E.J.M.

    2013-01-01

    I argue that structure building (e.g. Chomsky’s Merge) is not part of the narrow language faculty (FLN, contra Hauser, Chomsky & Fitch 2002). FLN is not empty, though: it consists of a lexico-grammatical component that defines grammatical objects, (non- recursive) combinatory rules/principles,

  15. Existing buildings

    DEFF Research Database (Denmark)

    Gram-Hanssen, Kirsten

    2014-01-01

    their homes. These policy measures include building regulations, energy tax and different types of incentives and information dissemination. The conclusion calls for new and innovative policy measures to cope with the realities of renovations of owner-occupied houses and how energy efficiency improvement...

  16. Building Trust.

    Science.gov (United States)

    Ambler, Marjane

    1994-01-01

    Describes how an initial $1,500 grant helped build a desperately needed health clinic on the Pine Ridge Reservation. Provides the history of the clinic, from its beginning as a small grant to its ultimate development into a $400,000 solar-heated health clinic with a staff of 9 people, including a full-time physician. (MAB)

  17. Disease-specific survival in de novo metastatic renal cell carcinoma in the cytokine and targeted therapy era.

    Directory of Open Access Journals (Sweden)

    Sumanta K Pal

    Full Text Available Recent phase III studies of targeted agents for metastatic renal cell carcinoma (mRCC have generated median survival estimates that far exceed those observed during the cytokine era. However, substantial population-based data does not exist to confirm this trend. We sought to determine whether survival has improved for patients with mRCC diagnosed in the era of targeted therapies, as compared to the era of immunotherapy.The Surveillance, Epidemiology, and End Results (SEER Registry was used to identify patients aged 18 and older diagnosed stage IV RCC between 1992 and 2009. Patients had documented clear cell, papillary or chromophobe histology. The Kaplan Meier method and log-rank test were used to compare disease-specific survival (DSS for patients diagnosed from 1992-2004 (i.e., the cytokine era and 2005-2009 (i.e., the targeted therapy era. Univariate and multivariate analyses of relevant clinicopathologic characteristics were also performed.Of 5,176 patients identified using the above characteristics, 2,392 patients were diagnosed from 1992-2004 and 2,784 from 2005-2009. Median DSS was improved in those patients diagnosed from 2005-2009 (16 months vs 13 months; P<0.0001. A similar temporal trend towards improving survival was noted in patients with clear cell (P = 0.0006, but not in patients with non-clear cell disease (P = 0.32. Notable findings on multivariate analysis include an association between shorter DSS and the following characteristics: (1 diagnosis from 1992-2004, (2 advanced age (80+, and (3 absence of cytoreductive nephrectomy.These data reflect progress in the management of mRCC, specifically in the era of targeted therapies. Notably, it was inferred that certain treatment strategies were employed during pre-specified time periods, representing a major caveat of the current analysis. Further studies related to the influence of age and race/ethnicity are warranted, as are studies exploring the role of cytoreductive nephrectomy

  18. Mobilization of peripheral blood progenitor cells by disease-specific chemotherapy in patients with soft tissue sarcoma.

    Science.gov (United States)

    Schwella, N; Rick, O; Meyer, O; Löffel, J; Schleicher, J; Serke, S; Huhn, D; Riess, H

    1998-05-01

    We investigated peripheral blood progenitor cell (PBPC) mobilization by disease-specific chemotherapy in patients with metastatic soft tissue sarcoma (STS). Nine patients, five females and four males, aged 12-51 years, pretreated by one to nine courses of cytotoxic chemotherapy, underwent STS-specific mobilization followed by G-CSF at 5 microg/kg/day. PBPC were collected by 19 conventional-volume aphereses (8-12 l) with one to four procedures in individual patients. Leukaphereses started on median day 15 (range 13-18) from the first day of mobilization chemotherapy at medians of 25.8 x 10(3) WBC/microl (6.8-46.9), 3.5 x 10(3) MNC/microl (1.1-8.8), 122 x 10(3) platelets/microl (72-293) and 30.7 CD34+ cells/microl (6.7-207.8). Cumulative harvests resulted in medians of 4.6 x 10(8) MNC/kg (3.0-6.4), 2.9 x 10(6) CD34+ cells/kg (1.1-11.1) and 12.0 x 10(4) CFU-GM/kg (2.0-37.8). Eight patients underwent high-dose chemotherapy (HDCT) followed by PBPC rescue. Seven patients recovered hematopoiesis at medians of 12 days (8-15) for ANC >0.5 x 10(3)/microl and 14 days (8-27) for platelets >20 x 10(3)/microl. One patient, who received 1.6 x 10(6) CD34+ cells/kg, exhibited delayed ANC recovery on day +37 and failed to recover platelets until hospital discharge on day +55. We conclude that in patients with metastatic STS, who are pretreated by standard chemotherapy, PBPC can be mobilized by a further course of STS-specific chemotherapy plus G-CSF. One to four conventional-volume aphereses result in PBPC autografts that can serve as hematopoietic rescue for patients scheduled for HDCT.

  19. The burden of disease of dental anxiety : generic and disease-specific quality of life in patients with and without extreme levels of dental anxiety

    NARCIS (Netherlands)

    Vermaire, J. H.; van Houtem, C. M. H. H.; Ross, J. N.; Schuller, A. A.

    2016-01-01

    The aim of this study was to compare disease-specific (oral health-related) quality of life (OHRQoL), assessed using the Oral Health Impact Profile-14 (OHIP-14), and generic (health-related) quality of life (HRQoL), assessed using the EuroQol5D (EQ-5D-5L), in patients with severe dental anxiety (who

  20. Psychometric properties of the TACQOL-asthma, a disease-specific measure of health related quality-of-life for children with asthma and their parents

    NARCIS (Netherlands)

    Flapper, Boudien C.T.; Koopman, H.M.; Ten Napel, C.; Van Der Schans, C.P.

    2006-01-01

    The disease-specific-TACQOL-asthma questionnaire measures health-status and appraisal of health-status. The TACQOL-asthma evaluates the personal feelings about problems in the domains, 'complaints, situations, emotions, treatment and medication'. The TACQOL-asthma can be used alone or in combination

  1. Comparison of internal and external responsiveness of the generic Medical Outcome Study Short Form-36 with disease-specific measures in rheumatoid arthritis

    NARCIS (Netherlands)

    Veehof, M.M.; ten Klooster, Peter M.; Taal, Erik; van Riel, Piet L.C.M.; van de Laar, Mart A F J

    2008-01-01

    OBJECTIVE: To examine the comparative internal and external responsiveness of the generic Medical Outcome Study Short Form-36 Health Survey (SF-36) and disease-specific measures in patients with rheumatoid arthritis (RA). METHODS: Data were collected from 280 RA patients starting anti-tumor necrosis

  2. Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument

    NARCIS (Netherlands)

    N. Von Steinbuechel (Nicole); A. Covic (Amra); S. Polinder (Suzanne); T. Kohlmann (Thomas); U. Cepulyte (Ugne); H. Poinstingl (Herbert); J. Backhaus (Joy); W. Bakx (Wilbert); M. Bullinger (Monika); A.-L. Christensen (Anne-Lise); R. Formisano (Rita); H. Gibbons (Henning); S. Höfer (Stefan); S. Koskinen (Sanna); A.I.R. Maas (Andrew); E. Neugebauer; J. Powell (Jane); J. Sarajuuri (Jaana); N. Sasse (Nadine); S. Schmidt (Silke); H. Mühlan (Holger); K. Von Wild (Klaus); G. Zitnay (George); J.-L. Truelle (Jean-Luc)

    2016-01-01

    textabstractPsychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI), potentially impacting health-related quality of life (HRQoL). Until now, however, neither the discriminatory power of disease-specific (QOLIBRI) and generic (SF-36) HRQoL nor their correlates

  3. Validation of the Disease-Specific Components of the Kidney Disease Quality of Life-36 (KDQOL-36 in Chinese Patients Undergoing Maintenance Dialysis.

    Directory of Open Access Journals (Sweden)

    Julie Y Chen

    Full Text Available The aim of this study was to evaluate the validity, reliability and sensitivity of the disease-specific items of the Kidney Disease Quality of Life-36 (KDQOL-36 in Chinese patients undergoing maintenance dialysis.The content validity was assessed by content validity index (CVI in ten subjects. 356 subjects were recruited for pilot psychometric testing. The internal construct validity was assessed by corrected item-subscale total correlation. Confirmatory factor analysis (CFA was used to confirm the factor structure. The convergent validity was assessed by Pearson's correlation test between the disease specific subscale scores and SF-12 version 2 Health Survey (SF-12 v2 scores. The reliability was assessed by the internal consistency (Cronbach's Alpha coefficient and 2-week test-retest reliability (intraclass correlation coefficient (ICC. The sensitivity was determined by performing known group comparisons by independent t-test.The CVI on clarity and relevance was ≥ 0.9 for all items. Corrected item- total correlation scores were ≥0.4 for all, except an item related to problems with access site. CFA confirmed the 3-factor structure of the disease-specific component of the KDQOL-36. The correlation coefficients between the disease-specific domain scores and the SF-12 v2 physical and mental component summary scores ranged from 0.328 to 0.492. The reliability was good (Cronbach's alpha coefficients ranged from 0.810 to 0.931, ICC ranged from 0.792 to 0.924. Only the effect subscale was sensitive in detecting differences in HRQOL between haemodialysis and peritoneal dialysis patients, with effect size = 0.68.The disease-specific items of the KDQOL-36 are a valid, reliable and sensitive measure to assess the health-related quality of life of Chinese patients on maintenance dialysis.

  4. Validation of the Disease-Specific Components of the Kidney Disease Quality of Life-36 (KDQOL-36) in Chinese Patients Undergoing Maintenance Dialysis.

    Science.gov (United States)

    Chen, Julie Y; Choi, Edmond P H; Wan, Eric Y F; Chan, Anca K C; Tsang, Joyce P Y; Chan, Karina H Y; Lo, W K; Lui, S L; Chu, W L; Lam, Cindy L K

    2016-01-01

    The aim of this study was to evaluate the validity, reliability and sensitivity of the disease-specific items of the Kidney Disease Quality of Life-36 (KDQOL-36) in Chinese patients undergoing maintenance dialysis. The content validity was assessed by content validity index (CVI) in ten subjects. 356 subjects were recruited for pilot psychometric testing. The internal construct validity was assessed by corrected item-subscale total correlation. Confirmatory factor analysis (CFA) was used to confirm the factor structure. The convergent validity was assessed by Pearson's correlation test between the disease specific subscale scores and SF-12 version 2 Health Survey (SF-12 v2) scores. The reliability was assessed by the internal consistency (Cronbach's Alpha coefficient) and 2-week test-retest reliability (intraclass correlation coefficient (ICC)). The sensitivity was determined by performing known group comparisons by independent t-test. The CVI on clarity and relevance was ≥ 0.9 for all items. Corrected item- total correlation scores were ≥0.4 for all, except an item related to problems with access site. CFA confirmed the 3-factor structure of the disease-specific component of the KDQOL-36. The correlation coefficients between the disease-specific domain scores and the SF-12 v2 physical and mental component summary scores ranged from 0.328 to 0.492. The reliability was good (Cronbach's alpha coefficients ranged from 0.810 to 0.931, ICC ranged from 0.792 to 0.924). Only the effect subscale was sensitive in detecting differences in HRQOL between haemodialysis and peritoneal dialysis patients, with effect size = 0.68. The disease-specific items of the KDQOL-36 are a valid, reliable and sensitive measure to assess the health-related quality of life of Chinese patients on maintenance dialysis.

  5. Building economics

    DEFF Research Database (Denmark)

    Pedersen, D.O.(red.)

    Publikationen er på engelsk. Den omfatter alle indlæg på det fjerde internationale symposium om byggeøkonomi, der blev arrangeret af SBI for det internationale byggeforskningsråd CIB. De fem bind omhandler: Methods of Economic Evaluation, Design Optimization, Ressource Utilization, The Building...... Market og Economics and Technological Forecasting in Construction. Et indledende bind bringer statusrapporter for de fem forskningsområder, og det sidste bind sammenfatter debatten på symposiet....

  6. Sustainable building versus ecological building

    CSIR Research Space (South Africa)

    Van Wyk, Llewellyn V

    2010-04-01

    Full Text Available and Grosskopf posit that in the future three basic contemporary approaches will be synthesised into an integrated process and that ecological design will become a part of a new design process. The three contemporary processes are: vernacular design..., the technological approach, and the biomimetic approach. Vernacular architecture is the embodiment of cultural wisdom, memory, tradition and intimate knowledge of place into the design and operation of buildings. Vernacular architecture speaks directly...

  7. Validation of celiac disease diagnoses recorded in the Danish National Patient Register using duodenal biopsies, celiac disease-specific antibodies, and human leukocyte-antigen genotypes

    DEFF Research Database (Denmark)

    Sander, Stine Dydensborg; Stordal, Ketil; Hansen, Tine Plato

    2016-01-01

    PURPOSE: The purpose of this study was to validate the celiac disease diagnoses recorded in the Danish National Patient Register. To validate the diagnoses, we used information on duodenal biopsies from a national register of pathology reports (the Patobank) and information on celiac disease......-specific antibodies and human leukocyte antigen (HLA) genotypes obtained from patient medical records. PATIENTS AND METHODS: We included all the children who were born from 1995 to 2012 and who were registered as having celiac disease in the Danish National Patient Register. We reviewed all the pathology reports...... on duodenal biopsies in the Patobank and the information in the medical records on celiac disease-specific antibodies (ie, anti-tissue transglutaminase 2 IgA and IgG, endomysial antibodies IgA, and anti-deamidated gliadin peptide IgG) and HLA genotypes. RESULTS: We identified 2,247 children who were...

  8. Patients are doing it for themselves: A survey on disease-specific knowledge acquisition among people with Parkinson's disease in Sweden.

    Science.gov (United States)

    Riggare, Sara; Höglund, Pär J; Hvitfeldt Forsberg, Helena; Eftimovska, Elena; Svenningsson, Per; Hägglund, Maria

    2017-04-01

    Effective self-management is key to living well with Parkinson's disease and one important aspect is disease-specific knowledge. This article explores how people with Parkinson's disease in Sweden (1) acquire disease-specific knowledge and (2) use Parkinson's disease-related healthcare. Data were collected through an online survey, which had 346 respondents (16-87 years old, median age: 68 years, 51% male; time since diagnosis: 0-31 years, median time: 7 years). Our results show that disease-specific knowledge is mainly found online, especially for women with Parkinson's disease and people with Parkinson's disease of working age, that most people with Parkinson's disease in Sweden see their neurologist for 1 h or less per year and only one in two people with Parkinson's disease has regular contact with other Parkinson's disease-related healthcare professionals. We also find that people with Parkinson's disease reporting higher levels of specific knowledge also are more likely to be satisfied with the amount of time they get with their neurologist, regardless of the amount of time.

  9. High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients.

    Science.gov (United States)

    Kalniete, Dagnija; Nakazawa-Miklaševiča, Miki; Štrumfa, Ilze; Āboliņš, Arnis; Irmejs, Arvīds; Gardovskis, Jānis; Miklaševičs, Edvīns

    2015-01-01

    Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study. Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test. MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p = 0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p = 0.0314). Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.

  10. Building Sandcastles

    DEFF Research Database (Denmark)

    Jensen, Steffen Moltrup Ernø; Korsgaard, Steffen; Shumar, Wes

    In this paper we focus on a hitherto somewhat overlooked aspect of entrepreneurship education, namely the influence of materiality and spatial context on the process of teaching and learning. In the paper we present an empirical examination oriented towards the material and spatial dimensions...... of entrepreneurship education. Our theoretical and methodological approach builds on Actor-Network Theory. The empirical settings of our study consist of two entrepreneurship courses which differ in terms of temporal extension and physical setting. Data is collected using observation and interview techniques. Our...... findings demonstrate the agency of material artefacts and how they enable teachers to act at a distance, by standing in as a scaffold that maintains the learning space as it interacts with the students. This acting at a distance however is highly uncertain and uncontrollable. Also we see how important...

  11. Integrating Responsive Building Elements in Buildings

    DEFF Research Database (Denmark)

    Haase, Matthias; Amato, Alex; Heiselberg, Per

    2006-01-01

    There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...... of responsive building elements, of integrated building concepts and of environmental performance assessment methods to improve and optimize responsive building elements to develop and optimize new building concepts with integration of responsive building elements, HVAC-systems as well as natural and renewable...... energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work and discusses its usefulness for Hong Kong and China. Special focus was put...

  12. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    Builders generally use a 'spec and purchase' business management system (BMS) when implementing energy efficiency. A BMS is the overall operational and organizational systems and strategies that a builder uses to set up and run its company. This type of BMS treats building performance as a simple technology swap (e.g. a tank water heater to a tankless water heater) and typically compartmentalizes energy efficiency within one or two groups in the organization (e.g. purchasing and construction). While certain tools, such as details, checklists, and scopes of work, can assist builders in managing the quality of the construction of higher performance homes, they do nothing to address the underlying operational strategies and issues related to change management that builders face when they make high performance homes a core part of their mission. To achieve the systems integration necessary for attaining 40% + levels of energy efficiency, while capturing the cost tradeoffs, builders must use a 'systems approach' BMS, rather than a 'spec and purchase' BMS. The following attributes are inherent in a systems approach BMS; they are also generally seen in quality management systems (QMS), such as the National Housing Quality Certification program: Cultural and corporate alignment, Clear intent for quality and performance, Increased collaboration across internal and external teams, Better communication practices and systems, Disciplined approach to quality control, Measurement and verification of performance, Continuous feedback and improvement, and Whole house integrated design and specification.

  13. Is diabetes mellitus associated with increased incidence and disease-specific mortality in endometrial cancer? A systematic review and meta-analysis of cohort studies.

    Science.gov (United States)

    Liao, Caiyun; Zhang, Dongyu; Mungo, Chemtai; Tompkins, D Andrew; Zeidan, Amer M

    2014-10-01

    To assess the association between diabetes mellitus (DM) and the incidence and disease-specific mortality of endometrial cancer (EC). MEDLINE, EMBASE and conference abstracts of the 2011-2013 Annual Meetings of Society of Gynecological Oncology were searched for reports of original cohort studies that enrolled diabetic and non-diabetic women who were free of EC at baseline to compare the incidence and disease-specific mortality of EC by DM status. The included reports were examined for demographic characteristics of study populations, study design, effect measures and risk of bias. Statistical heterogeneity was evaluated with Chi-square test of the Cochrane Q statistics at the 0.05 significance level and I(2) statistic. Publication bias was assessed by visual examination of a funnel plot and the Egger's test for small-study effects. Twenty-nine cohort studies (17 prospective, 12 retrospective) were eligible for this review, 23 of which reported EC incidence, five reported disease-specific mortality and one reported both. For incidence of EC among women with versus without DM, the summary relative risk (RR) was 1.89 (95%CI, 1.46-2.45; p<0.001) and the summary incidence rate ratio was 1.61 (95%CI, 1.51-1.71; p<0.001). The pooled RR of disease-specific mortality was 1.32 (95%CI, 1.10-1.60; p=0.003), while results in the studies reporting standardized mortality ratios were inconsistent. There remains considerable amount of clinical and methodological heterogeneity among the included studies; moreover, the hazard ratios for incident EC showed significant statistical heterogeneity and therefore were not quantitatively synthesized. There is consistent evidence for an independent association between DM and an increased risk of incident EC, while the association between DM and EC-specific mortality remains uncertain. Further studies with better considerations for selection bias, information bias and confounding will further facilitate causal inference involving DM and EC

  14. Correlations between disease-specific and generic health status questionnaires in patients with advanced COPD: a one-year observational study

    Directory of Open Access Journals (Sweden)

    Wilke Sarah

    2012-08-01

    Full Text Available Abstract Background Longitudinal studies analyzing the correlations between disease-specific and generic health status questionnaires at different time points in patients with advanced COPD are lacking. The aim of this study was to determine whether and to what extent a disease-specific health status questionnaire (Saint George’s Respiratory Questionnaire, SGRQ correlates with generic health status questionnaires (EuroQol-5-Dimensions, EQ-5D; Assessment of Quality of Life instrument, AQoL; Medical Outcomes Study 36-Item Short-Form Health Survey, SF-36 at four different time points in patients with advanced COPD; and to determine the correlation between the changes in these questionnaires during one-year follow-up. Methods Demographic and clinical characteristics were assessed in 105 outpatients with advanced COPD at baseline. Disease-specific health status (SGRQ and generic health status (EQ-5D, AQoL, SF-36 were assessed at baseline, four, eight, and 12 months. Correlations were determined between SGRQ and EQ-5D, AQoL, and SF-36 scores and changes in these scores. Agreement in direction of change was assessed. Results Eighty-four patients (80% completed one-year follow-up and were included for analysis. SGRQ total score and EQ-5D index score, AQoL total score and SF-36 Physical Component Summary measure (SF-36 PCS score were moderately to strongly correlated. The correlation of the changes between the SGRQ total score and EQ-5D index score, AQoL total score, SF-36 PCS, and SF-36 Mental Component Summary measure (SF-36 MCS score were weak or absent. The direction of changes in SGRQ total scores agreed slightly with the direction of changes in EQ-5D index score, AQoL total score, and SF-36 PCS score. Conclusions At four, eight and 12 months after baseline, SGRQ total scores and EQ-5D index scores, AQoL total scores and SF-36 PCS scores were moderately to strongly correlated, while SGRQ total scores were weakly correlated with SF-36 MCS scores

  15. An oral cavity squamous cell carcinoma quantitative histomorphometric-based image classifier of nuclear morphology can risk stratify patients for disease-specific survival.

    Science.gov (United States)

    Lu, Cheng; Lewis, James S; Dupont, William D; Plummer, W Dale; Janowczyk, Andrew; Madabhushi, Anant

    2017-12-01

    Oral cavity squamous cell carcinoma is the most common type of head and neck carcinoma. Its incidence is increasing worldwide, and it is associated with major morbidity and mortality. It is often unclear which patients have aggressive, treatment refractory tumors vs those whose tumors will be more responsive to treatment. Better identification of patients with high- vs low-risk cancers could help provide more tailored treatment approaches and could improve survival rates while decreasing treatment-related morbidity. This study investigates computer-extracted image features of nuclear shape and texture on digitized images of H&E-stained tissue sections for risk stratification of oral cavity squamous cell carcinoma patients compared with standard clinical and pathologic parameters. With a tissue microarray cohort of 115 retrospectively identified oral cavity squamous cell carcinoma patients, 50 were randomly chosen as the modeling set, and the remaining 65 constituted the test set. Following nuclear segmentation and feature extraction, the Wilcoxon rank sum test was used to identify the five most prognostic quantitative histomorphometric features from the modeling set. These top ranked features were then combined via a machine learning classifier to construct the oral cavity histomorphometric-based image classifier (OHbIC). The classifier was then validated for its ability to risk stratify patients for disease-specific outcomes on the test set. On the test set, the classifier yielded an area under the receiver operating characteristic curve of 0.72 in distinguishing disease-specific outcomes. In univariate survival analysis, high-risk patients predicted by the classifier had significantly poorer disease-specific survival (P=0.0335). In multivariate analysis controlling for T/N-stage, resection margins, and smoking status, positive classifier results were independently predictive of poorer disease-specific survival: hazard ratio (95% confidence interval)=11.023 (2

  16. Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.

    Directory of Open Access Journals (Sweden)

    Montiago X LaBute

    Full Text Available Late-stage or post-market identification of adverse drug reactions (ADRs is a significant public health issue and a source of major economic liability for drug development. Thus, reliable in silico screening of drug candidates for possible ADRs would be advantageous. In this work, we introduce a computational approach that predicts ADRs by combining the results of molecular docking and leverages known ADR information from DrugBank and SIDER. We employed a recently parallelized version of AutoDock Vina (VinaLC to dock 906 small molecule drugs to a virtual panel of 409 DrugBank protein targets. L1-regularized logistic regression models were trained on the resulting docking scores of a 560 compound subset from the initial 906 compounds to predict 85 side effects, grouped into 10 ADR phenotype groups. Only 21% (87 out of 409 of the drug-protein binding features involve known targets of the drug subset, providing a significant probe of off-target effects. As a control, associations of this drug subset with the 555 annotated targets of these compounds, as reported in DrugBank, were used as features to train a separate group of models. The Vina off-target models and the DrugBank on-target models yielded comparable median area-under-the-receiver-operating-characteristic-curves (AUCs during 10-fold cross-validation (0.60-0.69 and 0.61-0.74, respectively. Evidence was found in the PubMed literature to support several putative ADR-protein associations identified by our analysis. Among them, several associations between neoplasm-related ADRs and known tumor suppressor and tumor invasiveness marker proteins were found. A dual role for interstitial collagenase in both neoplasms and aneurysm formation was also identified. These associations all involve off-target proteins and could not have been found using available drug/on-target interaction data. This study illustrates a path forward to comprehensive ADR virtual screening that can potentially scale with

  17. Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.

    Science.gov (United States)

    LaBute, Montiago X; Zhang, Xiaohua; Lenderman, Jason; Bennion, Brian J; Wong, Sergio E; Lightstone, Felice C

    2014-01-01

    Late-stage or post-market identification of adverse drug reactions (ADRs) is a significant public health issue and a source of major economic liability for drug development. Thus, reliable in silico screening of drug candidates for possible ADRs would be advantageous. In this work, we introduce a computational approach that predicts ADRs by combining the results of molecular docking and leverages known ADR information from DrugBank and SIDER. We employed a recently parallelized version of AutoDock Vina (VinaLC) to dock 906 small molecule drugs to a virtual panel of 409 DrugBank protein targets. L1-regularized logistic regression models were trained on the resulting docking scores of a 560 compound subset from the initial 906 compounds to predict 85 side effects, grouped into 10 ADR phenotype groups. Only 21% (87 out of 409) of the drug-protein binding features involve known targets of the drug subset, providing a significant probe of off-target effects. As a control, associations of this drug subset with the 555 annotated targets of these compounds, as reported in DrugBank, were used as features to train a separate group of models. The Vina off-target models and the DrugBank on-target models yielded comparable median area-under-the-receiver-operating-characteristic-curves (AUCs) during 10-fold cross-validation (0.60-0.69 and 0.61-0.74, respectively). Evidence was found in the PubMed literature to support several putative ADR-protein associations identified by our analysis. Among them, several associations between neoplasm-related ADRs and known tumor suppressor and tumor invasiveness marker proteins were found. A dual role for interstitial collagenase in both neoplasms and aneurysm formation was also identified. These associations all involve off-target proteins and could not have been found using available drug/on-target interaction data. This study illustrates a path forward to comprehensive ADR virtual screening that can potentially scale with increasing number

  18. Analysis of multi-site drug-protein interactions by high-performance affinity chromatography: Binding by glimepiride to normal or glycated human serum albumin.

    Science.gov (United States)

    Matsuda, Ryan; Li, Zhao; Zheng, Xiwei; Hage, David S

    2015-08-21

    High-performance affinity chromatography (HPAC) was used in a variety of formats to examine multi-site interactions between glimepiride, a third-generation sulfonylurea drug, and normal or in vitro glycated forms of the transport protein human serum albumin (HSA). Frontal analysis revealed that glimepiride interacts with normal HSA and glycated HSA at a group of high affinity sites (association equilibrium constant, or Ka, 9.2-11.8×10(5)M(-1) at pH 7.4 and 37°C) and a group of lower affinity regions (Ka, 5.9-16×10(3)M(-1)). Zonal elution competition studies were designed and carried out in both normal- and reversed-role formats to investigate the binding by this drug at specific sites. These experiments indicated that glimepiride was interacting at both Sudlow sites I and II. Allosteric effects were also noted with R-warfarin at Sudlow site I and with tamoxifen at the tamoxifen site on HSA. The binding at Sudlow site I had a 2.1- to 2.3-fold increase in affinity in going from normal HSA to the glycated samples of HSA. There was no significant change in the affinity for glimepiride at Sudlow site II in going from normal HSA to a moderately glycated sample of HSA, but a slight decrease in affinity was seen in going to a more highly glycated HSA sample. These results demonstrated how various HPAC-based methods can be used to profile and characterize multi-site binding by a drug such as glimepiride to a protein and its modified forms. The information obtained from this study should be useful in providing a better understanding of how drug-protein binding may be affected by glycation and of how separation and analysis methods based on HPAC can be employed to study systems with complex interactions or that involve modified proteins. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Net-zero building

    CSIR Research Space (South Africa)

    Van Wyk, Llewellyn V

    2013-01-01

    Full Text Available of interventions where innovative technologies could realise substantial building performance improvements. A central challenge to construction and building performance is located in the practice of constructing a building on the project site using a combination...

  20. BUILDING 341 Seismic Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Halle, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-06-15

    The Seismic Evaluation of Building 341 located at Lawrence Livermore National Laboratory in Livermore, California has been completed. The subject building consists of a main building, Increment 1, and two smaller additions; Increments 2 and 3.

  1. Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI with a Generic (SF-36 Instrument

    Directory of Open Access Journals (Sweden)

    Nicole von Steinbuechel

    2016-01-01

    Full Text Available Psychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI, potentially impacting health-related quality of life (HRQoL. Until now, however, neither the discriminatory power of disease-specific (QOLIBRI and generic (SF-36 HRQoL nor their correlates have been compared in detail. These aspects as well as some psychometric item characteristics were studied in a sample of 795 TBI survivors. The Shannon H' index absolute informativity, as an indicator of an instrument’s power to differentiate between individuals within a specific group or health state, was investigated. Psychometric performance of the two instruments was predominantly good, generally higher, and more homogenous for the QOLIBRI than for the SF-36 subscales. Notably, the SF-36 “Role Physical,” “Role Emotional,” and “Social Functioning” subscales showed less satisfactory discriminatory power than all other dimensions or the sum scores of both instruments. The absolute informativity of disease-specific as well as generic HRQoL instruments concerning the different groups defined by different correlates differed significantly. When the focus is on how a certain subscale or sum score differentiates between individuals in one specific dimension/health state, the QOLIBRI can be recommended as the preferable instrument.

  2. Comparison of a radiomic biomarker with volumetric analysis for decoding tumour phenotypes of lung adenocarcinoma with different disease-specific survival

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Mei; Zhang, Yu-Dong; Pu, Xue-Hui; Zhong, Yan; Yu, Tong-Fu [First Affiliated Hospital of Nanjing Medical University, Department of Radiology, Nanjing, Jiangsu Province (China); Li, Hai [First Affiliated Hospital of Nanjing Medical University, Department of Pathology, Nanjing (China); Wu, Jiang-Fen [GE Healthcare, Shanghai (China)

    2017-11-15

    To compare a multi-feature-based radiomic biomarker with volumetric analysis in discriminating lung adenocarcinomas with different disease-specific survival on computed tomography (CT) scans. This retrospective study obtained institutional review board approval and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Pathologically confirmed lung adenocarcinoma (n = 431) manifested as subsolid nodules on CT were identified. Volume and percentage solid volume were measured by using a computer-assisted segmentation method. Radiomic features quantifying intensity, texture and wavelet were extracted from the segmented volume of interest (VOI). Twenty best features were chosen by using the Relief method and subsequently fed to a support vector machine (SVM) for discriminating adenocarcinoma in situ (AIS)/minimally invasive adenocarcinoma (MIA) from invasive adenocarcinoma (IAC). Performance of the radiomic signatures was compared with volumetric analysis via receiver-operating curve (ROC) analysis and logistic regression analysis. The accuracy of proposed radiomic signatures for predicting AIS/MIA from IAC achieved 80.5% with ROC analysis (Az value, 0.829; sensitivity, 72.1%; specificity, 80.9%), which showed significantly higher accuracy than volumetric analysis (69.5%, P = 0.049). Regression analysis showed that radiomic signatures had superior prognostic performance to volumetric analysis, with AIC values of 81.2% versus 70.8%, respectively. The radiomic tumour-phenotypes biomarker exhibited better diagnostic accuracy than traditional volumetric analysis in discriminating lung adenocarcinoma with different disease-specific survival. (orig.)

  3. Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument

    Science.gov (United States)

    von Steinbuechel, Nicole; Covic, Amra; Polinder, Suzanne; Kohlmann, Thomas; Cepulyte, Ugne; Poinstingl, Herbert; Backhaus, Joy; Bakx, Wilbert; Bullinger, Monika; Christensen, Anne-Lise; Formisano, Rita; Gibbons, Henning; Höfer, Stefan; Koskinen, Sanna; Maas, Andrew; Neugebauer, Edmund; Powell, Jane; Sarajuuri, Jaana; Sasse, Nadine; Schmidt, Silke; Mühlan, Holger; von Wild, Klaus; Zitnay, George; Truelle, Jean-Luc

    2016-01-01

    Psychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI), potentially impacting health-related quality of life (HRQoL). Until now, however, neither the discriminatory power of disease-specific (QOLIBRI) and generic (SF-36) HRQoL nor their correlates have been compared in detail. These aspects as well as some psychometric item characteristics were studied in a sample of 795 TBI survivors. The Shannon H ' index absolute informativity, as an indicator of an instrument's power to differentiate between individuals within a specific group or health state, was investigated. Psychometric performance of the two instruments was predominantly good, generally higher, and more homogenous for the QOLIBRI than for the SF-36 subscales. Notably, the SF-36 “Role Physical,” “Role Emotional,” and “Social Functioning” subscales showed less satisfactory discriminatory power than all other dimensions or the sum scores of both instruments. The absolute informativity of disease-specific as well as generic HRQoL instruments concerning the different groups defined by different correlates differed significantly. When the focus is on how a certain subscale or sum score differentiates between individuals in one specific dimension/health state, the QOLIBRI can be recommended as the preferable instrument. PMID:27022207

  4. The Huntington's Disease health-related Quality of Life questionnaire (HDQoL): a disease-specific measure of health-related quality of life

    Science.gov (United States)

    Hocaoglu, MB; Gaffan, EA; Ho, AK

    2012-01-01

    Hocaoglu MB, Gaffan EA, Ho AK. The Huntington's disease health-related quality of life questionnaire: a disease-specific measure of health-related quality of life. Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by motor, cognitive and psychiatric disturbances, and yet there is no disease-specific patient-reported health-related quality of life outcome measure for patients. Our aim was to develop and validate such an instrument, i.e. the Huntington's Disease health-related Quality of Life questionnaire (HDQoL), to capture the true impact of living with this disease. Semi-structured interviews were conducted with the full spectrum of people living with HD, to form a pool of items, which were then examined in a larger sample prior to data-driven item reduction. We provide the statistical basis for the extraction of three different sets of scales from the HDQoL, and present validation and psychometric data on these scales using a sample of 152 participants living with HD. These new patient-derived scales provide promising patient-reported outcome measures for HD. Section Editor: Aad Tibben, email: a.tibben@lumc.nl PMID:22151007

  5. Danish building typologies and building stock analyses

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne; Kragh, Jesper

    enough to meet the government’s plan to make Danish buildings free from use of fossil fuels by 2035. This will probably require around 50 % energy savings in the Danish building stock as a whole. However, the project has proven that dedicated engagement of locals can speed up market penetration...... energy savings in residential buildings. The intension with this analysis was to investigate the possible energy reduction in Denmark if the same approach had been taken for the entire Danish building stock. The report concludes that the ZeroHome initiative clearly results in energy savings, but far from...... for energy savings in the existing Building stock....

  6. Danish building typologies

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne; Kragh, Jesper

    The objective of TABULA is to develop a harmonised building typology for European countries. Each national building typology will consist of a set of residential model buildings with characteristic energy-related properties (element areas of the thermal building envelope, U-values, supply system...... efficiencies). The model buildings will each represent a specific construction period of the country in question and a specific building size. Furthermore the number of buildings, flats and the overall floor areas will be given, which are represented by the different building types of the national typologies....

  7. Delta-He, Ret-He and a New Diagnostic Plot for Differential Diagnosis and Therapy Monitoring of Patients Suffering from Various Disease-Specific Types of Anemia.

    Science.gov (United States)

    Weimann, Andreas; Cremer, Malte; Hernáiz-Driever, Pablo; Zimmermann, Mathias

    2016-01-01

    The present study was aimed to prove the usefulness of a new diagnostic plot (Hema-Plot), illustrating the relationship between the hemoglobin content of reticulocytes (Ret-He) as a marker of functional iron deficiency and the difference between the reticulocyte and erythrocyte hemoglobin content (Delta-He) as a marker of an impaired hemoglobinization of newly formed reticulocytes occurring during inflammatory processes, to differentiate between various disease-specific types of anemia. A complete blood and reticulocyte count was performed on routine EDTA blood samples from 345 patients with and without various disease-specific types of anemia using the Sysmex XN-9000 hematology analyzer: blood healthy newborns (n = 23), blood healthy adults (n = 31), patients suffering from anemia of chronic disease (ACD) due to diverse oncological, chronic inflammatory, or autoimmune diseases (total n = 138) with (n = 65) and without therapy (n = 73), patients with thalassemia and/or hemoglobinopathy (n = 18), patients with iron deficiency anemia (IDA) (n = 35), patients with a combination of ACD and IDA (n = 17), as well as patients suffering from sepsis (total n = 83) with (n = 32) and without therapy (n = 51). The results for Ret-He, Delta-He, and C-reactive protein (CRP) were statistically compared (Mann-Whitney U Test) between the particular patient groups and the diagnostic plots were drawn. Delta-Hemoglobin showed a statistically significant difference between blood healthy newborns and blood healthy adults (p ≤ 0.05), while Ret-He and C-reactive protein did not. In addition, of all three biomarkers only Delta-He showed a statistically significant difference (p ≤ 0.05) between the ACD/IDA and IDA cohort. Delta-He, Ret-He, and CRP showed a statistically significant difference between patient cohorts with and without therapy suffering from ACD, ACD/IDA, and sepsis before and after medical therapy (p ≤ 0.05). The Hema-Plot illustrated the dynamic character of Ret-He and

  8. Global Building Physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2012-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or “global”, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. The keynote lecture and this brief paper...

  9. Global building physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2013-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or ‘global’, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. This brief article reports the keynote...

  10. Overlapping and disease specific aspects of impulsivity in children and adolescents with schizophrenia spectrum disorders or Attention-Deficit/Hyperactivity Disorder

    DEFF Research Database (Denmark)

    Jepsen, Jens Richardt Møllegaard; Rydkjær, Jacob; Fagerlund, Birgitte

    Objectives: To identify disease specific and overlapping aspects of impulsivity in children and adolescents with early-onset schizophrenia spectrum disorders or ADHD. Methods: Motor impulsivity (Stop Signal Task), reflection impulsivity (Information Sampling Task), and trait impulsivity (Barratt...... Impulsiveness Scale) are compared between three groups of children and adolescents between 12 and 17 years of age: patients with early-onset schizophrenia spectrum disorders (N=29), patients with ADHD (N=29), and healthy controls (N=45). Results: Preliminary results: Reflection impulsivity is significantly...... increased in patients with ADHD but not in early-onset schizophrenia spectrum disorder patients who perform non-significantly different from the healthy controls in the decreased win condition. Discussion: Reduced information sampling in children and adolescents with ADHD may reflect an inability to delay...

  11. Overlapping and disease specific aspects of impulsivety in children and adolescents with schiozphrenia spectrum disorders or Attention-Deficit/Hyperactivity Disorder

    DEFF Research Database (Denmark)

    Jepsen, Jens Richardt Møllegaard; Rydkjær, Jacob; Fagerlund, Birgitte

    Background and aim: Dimensions of impulsivity have been observed in Attention-Deficit/Hyperactivity Disorder (ADHD) and schizophrenia patients. The purpose is to identify disease specific and overlapping aspects of impulsivity in children and adolescents with ADHD or early-onset schizophrenia......-onset schizophrenia spectrum disorders (N-29), patients with ADHD (N=29), and healthy controls (N=45). Results: preliminary results: Compared to healthy controls, reflection impulsivity is significantly increased in patients with ADHD in a condition with a confluct between reward and certainty. Early......-onset schizophrenia spectrum disorder patients appear to perform differently from the healthy controls and the schizphrenia spectrum disorder patients, although not signivicantly (p = .163). Conclusion: Reduced information sampling in children and adolescents with ADHD may reflect an inability to delay their decision...

  12. Overlapping and disease specific trait, response, and reflection impulsivity in adolescents with first-episode schizophrenia spectrum disorders or attention-deficit/hyperactivity disorder

    DEFF Research Database (Denmark)

    Jepsen, J. R.M.; Rydkjaer, J.; Fagerlund, B.

    2017-01-01

    Background: Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) are developmental disorders with shared clinical characteristics such as cognitive impairments and impulsivity. Impulsivity is a core feature of ADHD and an important factor in aggression, violence, and substance use...... in schizophrenia. Based on the hypothesis that schizophrenia and ADHD represent a continuum of neurodevelopmental impairments, the aim was to identify overlapping and disease specific forms of impulsivity. Methods: Adolescents between 12 and 17 years of age were assessed with the Schedule for Affective Disorders...... and Schizophrenia for School-aged Children – Present and Lifetime Version. Subjects with early-onset, first-episode schizophrenia spectrum disorders (EOS) (N = 29) or ADHD (N = 29) and healthy controls (N = 45) were compared on two performance measures (Information Sampling Task, Stop Signal Task) and a subjective...

  13. ICT Enhanced Buildings Potentials

    DEFF Research Database (Denmark)

    Christiansson, Per

    2007-01-01

    The paper describes and gives example on how Information and Communication, ICT, can and will enhance and support the building functional systems defined from client and end-user needs and requirements. The building systems may be derived from functional requirements on buildings such as usability...... and security on highest level with sub-systems definitions on lever levels. Building functional sub-systems may be defined for user comfort, indoor-climate, evacuation, space configuration, aesthetics, O&M etc. These building systems are supported by Information and Communication Technology, ICT, and building...... component systems that are accessed and integrated in the real world of building use in different contexts. The ICT systems may be physically or virtually embedded in the building. Already in 1982 AT&T established the 'intelligent buildings', IB, concept due to marketing reasons and the Informart building...

  14. Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.

    Science.gov (United States)

    Denton, Kyle R; Lei, Ling; Grenier, Jeremy; Rodionov, Vladimir; Blackstone, Craig; Li, Xue-Jun

    2014-02-01

    Human neuronal models of hereditary spastic paraplegias (HSP) that recapitulate disease-specific axonal pathology hold the key to understanding why certain axons degenerate in patients and to developing therapies. SPG4, the most common form of HSP, is caused by autosomal dominant mutations in the SPAST gene, which encodes the microtubule-severing ATPase spastin. Here, we have generated a human neuronal model of SPG4 by establishing induced pluripotent stem cells (iPSCs) from an SPG4 patient and differentiating these cells into telencephalic glutamatergic neurons. The SPG4 neurons displayed a significant increase in axonal swellings, which stained strongly for mitochondria and tau, indicating the accumulation of axonal transport cargoes. In addition, mitochondrial transport was decreased in SPG4 neurons, revealing that these patient iPSC-derived neurons recapitulate disease-specific axonal phenotypes. Interestingly, spastin protein levels were significantly decreased in SPG4 neurons, supporting a haploinsufficiency mechanism. Furthermore, cortical neurons derived from spastin-knockdown human embryonic stem cells (hESCs) exhibited similar axonal swellings, confirming that the axonal defects can be caused by loss of spastin function. These spastin-knockdown hESCs serve as an additional model for studying HSP. Finally, levels of stabilized acetylated-tubulin were significantly increased in SPG4 neurons. Vinblastine, a microtubule-destabilizing drug, rescued this axonal swelling phenotype in neurons derived from both SPG4 iPSCs and spastin-knockdown hESCs. Thus, this study demonstrates the successful establishment of human pluripotent stem cell-based neuronal models of SPG4, which will be valuable for dissecting the pathogenic cellular mechanisms and screening compounds to rescue the axonal degeneration in HSP. © AlphaMed Press.

  15. A disease-specific quality of life instrument for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: CLDQ-NAFLD.

    Science.gov (United States)

    Younossi, Zobair M; Stepanova, Maria; Henry, Linda; Racila, Andrei; Lam, Brian; Pham, Huong T; Hunt, Sharon

    2017-08-01

    Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are the most common causes of chronic liver disease with known negative impact on patients' health-related quality of life. Our aim was to validate a disease-specific health-related quality of life instrument useful for efficacy trials involving patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. From a long item selection questionnaire, we selected relevant items which, by factor analysis, were grouped into domains constituting Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version. The developed instrument was subjected to internal validity, test-retest reliability and construct validity assessment using standard methods. For development of the Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version instrument, a 75-item-long item selection questionnaire was administered to 25 patients with non-alcoholic fatty liver disease. After item reduction, factor analysis found that 98.7% of variance in the remaining items would be explained by six factors. Thus, the resulting Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version instrument had 36 items grouped into six domains: Abdominal Symptoms, Activity, Emotional, Fatigue, Systemic Symptoms, and Worry. The independent validation group included another 104 patients with non-alcoholic fatty liver disease. The Cronbach's alphas of 0.74-0.90 suggested good to excellent internal consistency of the domains. Furthermore, the presence of obesity and history of depression were discriminated best by Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version scores (P.15, intraclass correlations .76-.88). The Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version is a disease-specific health-related quality of life instrument developed and validated using an established methodology and useful for clinical trials of non

  16. Activities of daily living dependency and disease-specific mortality during 12-year follow-up in an 80-year-old population.

    Science.gov (United States)

    Takata, Yutaka; Ansai, Toshihiro; Soh, Inho; Awano, Shuji; Nakamichi, Ikuo; Akifusa, Sumio; Goto, Kenichi; Yoshida, Akihiro; Sonoki, Kazuo

    2013-05-01

    Although total mortality is likely to be higher in elderly individuals with frailty or impaired activities of daily living (ADL), little is known about the relationships between disease-specific mortality and ADL dependency in the elderly. Therefore, we examined whether 12-year disease-specific mortality may be associated with ADL dependency in an 80-year-old population. In 1998, of 1,282 community-dwelling residents of Japan's Fukuoka Prefecture, 824 (64.3 %) (309 males and 515 females) participated, the remaining 458 subjects did not participate, and their deaths and causes of death were followed up for 12 years after the baseline examination. ADL dependency was determined according to the guidelines for disabled elderly from the Health, Labor, and Welfare Ministry of Japan, and ADL dependency was measured only at baseline. During the 12-year follow-up, 506 died, 276 did not die, and 42 were lost. Of the 506 who died, 128 died due to cardiovascular disease, 96 to respiratory tract disease, 87 to cancer, and 51 to senility. The subjects were classified into three groups as follows: ADL-1 (independent group, n = 600), ADL-2 (almost-independent group, n = 113), and ADL-3 (dependent group, n = 93).Total-cause mortality was 2.8 times higher in ADL-3 subjects, respiratory disease mortality was 4.1 times higher in ADL-3 subjects, and senility mortality was 5.7 times higher in ADL-3 subjects than in ADL-1 subjects, after adjusting for various confounding factors. There was no association between mortality due to cancer or cardiovascular disease and ADL dependency. We found an independent association between ADL dependency and mortality due to all causes, respiratory disease or senility, but no association with mortality due to cancer or cardiovascular disease. These findings suggest that improving ADL dependency may reduce all mortality and mortality due to respiratory disease or senility.

  17. Association of disease-specific causes of visual impairment and 10-year mortality amongst Indigenous Australians: the Central Australian Ocular Health Study.

    Science.gov (United States)

    Estevez, José; Kaidonis, Georgia; Henderson, Tim; Craig, Jamie E; Landers, John

    2018-01-01

    Visual impairment significantly impairs the length and quality of life, but little is known of its impact in Indigenous Australians. To investigate the association of disease-specific causes of visual impairment with all-cause mortality. A retrospective cohort analysis. A total of 1347 Indigenous Australians aged over 40 years. Participants visiting remote medical clinics underwent clinical examinations including visual acuity, subjective refraction and slit-lamp examination of the anterior and posterior segments. The major ocular cause of visual impairment was determined. Patients were assessed periodically in these remote clinics for the succeeding 10 years after recruitment. Mortality rates were obtained from relevant departments. All-cause 10-year mortality and its association with disease-specific causes of visual impairment. The all-cause mortality rate for the entire cohort was 29.3% at the 10-year completion of follow-up. Of those with visual impairment, the overall mortality rate was 44.9%. The mortality rates differed for those with visual impairment due to cataract (59.8%), diabetic retinopathy (48.4%), trachoma (46.6%), 'other' (36.2%) and refractive error (33.4%) (P visual impairment from diabetic retinopathy were any more likely to die during the 10 years of follow-up when compared with those without visual impairment (HR 1.70; 95% CI, 1.00-2.87; P = 0.049). Visual impairment was associated with all-cause mortality in a cohort of Indigenous Australians. However, diabetic retinopathy was the only ocular disease that significantly increased the risk of mortality. Visual impairment secondary to diabetic retinopathy may be an important predictor of mortality. © 2017 Royal Australian and New Zealand College of Ophthalmologists.

  18. Are generic and disease-specific health related quality of life correlated? The case of chronic lung disease due to sulfur mustard

    Directory of Open Access Journals (Sweden)

    Shervin Assari

    2009-09-01

    Full Text Available

    • BACKGROUND: The aim of this study was to investigate the association between the two most commonly used generic and disease specific health-related quality of life (HRQoL measures in patients with chronic lung disease due to SM: Medical Outcomes Study Short Form 36-Item (SF-36 and St George's Respiratory Questionnaire (SGRQ.
    • METHODS: This is a secondary analysis of Iranian Chemical Warfare Victims Health Assessment Study (ICWVHAS during October 2007 in Isfahan, Iran. In that survey, conducted in an outpatient setting, 292 patients with chronic lung disease due to SM were selected from all provinces in Iran. The total score and sub scores of correlations of SGRQ and SF-36 were assessed. Correlation of quality-of-life scores were evaluated using Pearson’s coefficient.
    • RESULTS: Samples were 276 patients who were selected for our analysis. No significant correlation was found between the total score or sub scores of SF-36 and the total score or sub scores of SGRQ (p > 0.05.
    • CONCLUSIONS: In patients with chronic lung disease due to SM, the SF-36 and SGRQ assess different aspects of HRQoL. Therefore applying both of them together, at least in the research setting is suggested.
    • KEYWORDS: Chronic Lung Disease, Health Related Quality of Life, Generic Health Related Quality of Life, Disease Specific Health Related Quality of Life, Sulfur Mustard.

  19. Instruments for disease-specific quality-of-life measurement in patients with type 2 diabetes mellitus--a systematic review.

    Science.gov (United States)

    Levterova, Boryana A; Dimitrova, Donka D; Levterov, Georgi E; Dragova, Elena A

    2013-01-01

    Diabetes mellitus is a disease which carries a considerable social impact in Bulgaria and across the world because of its high prevalence. Research literature has recently included lots of studies investigating the effects of diabetes mellitus on the quality of life of diabetic patients and also many instruments to assess these effects. Quality of life is a concept that encompasses an individual's subjective perception of physical, emotional and social wellbeing, including both a cognitive component (satisfaction) and an emotional component (happiness). We review and analyse in the present article major determinants of disease-specific quality of life in patients with type 2 diabetes mellitus and the tools used for assessment. Fourteen instruments for measuring quality of life in type 2 diabetes mellitus (T2DM) met our search criteria. Their contents covered different quality-of-life domains or indicators-- typical diabetes symptoms, general health and quality of life, personality traits, physical functioning, mental and social well-being, treatment and quality of life. Most of the disease-specific tools had been field tested and data about their reliability and validity have been reported. Few tools had been subjected to formal assessment of their adaptability to changes. Of the instruments we assessed the most promising approaches for measuring the diabetes-specific quality of life are offered by ADDQoL, DCP and WBQ. Patients were involved in the development of these tools which have been shown by a number of studies to have good internal reliability, external and construct validity. Efforts are being continually made worldwide to develop a standard ensuring valid, reliable, easy to use tool for assessing quality of life in patients with type 2 diabetes mellitus in order to promote patients integration into society.

  20. The meaning of (quality of) life in patients with eating disorders: a comparison of generic and disease-specific measures across diagnosis and outcome.

    Science.gov (United States)

    Ackard, Diann M; Richter, Sara; Egan, Amber; Engel, Scott; Cronemeyer, Catherine L

    2014-04-01

    Compare general and disease-specific health-related quality of life (HRQoL) among female patients with an eating disorder (ED). Female patients (n = 221; 95.3% Caucasian; 94.0% never married) completed the Medical Outcome Short Form Health Survey (SF-36) and Eating Disorders Quality of Life (EDQoL) as part of a study of treatment outcomes. Multivariate regression models were used to compare HRQoL differences across initial ED diagnosis (85 AN-R, 19 AN-B/P, 27 BN, 90 EDNOS) and ED diagnostic classification at time of outcome assessment (140 no ED, 38 subthreshold ED, 43 full threshold ED). There were no significant differences across ED diagnosis at initial assessment on either of the SF-36 Component Summary scores. However, patients with AN-B/P scored poorer on the work/school EDQoL subscales than other ED diagnoses, and on the psychological EDQoL subscale compared to AN-R and EDNOS. At outcome assessment, comparisons across full threshold, subthreshold and no ED classification indicated that those with no ED reported better HRQoL than those with full threshold ED on the SF-36 Mental Components Summary and three of four EDQoL subscales. Furthermore, those with no ED reported better psychological HRQoL than those with subthreshold ED. Disease-specific HRQOL measures are important to use when comparing HRQoL in ED patients across treatment and outcome, and may have the sensitivity to detect meaningful differences by diagnosis more so than generic instruments. EDQoL scores from patients remitted from symptoms approach but do not reach scores for unaffected college females; thus, treatment should continue until quality of life is restored. Copyright © 2013 Wiley Periodicals, Inc.

  1. Health-related quality of life in ANCA-associated vasculitis and item generation for a disease-specific patient-reported outcome measure

    Science.gov (United States)

    Robson, Joanna C; Dawson, Jill; Cronholm, Peter F; Milman, Nataliya; Kellom, Katherine S; Ashdown, Susan; Easley, Ebony; Farrar, John T; Gebhart, Don; Lanier, Georgia; McAlear, Carol A; Peck, Jacqueline; Luqmani, Raashid A; Shea, Judy A; Tomasson, Gunnar; Merkel, Peter A

    2018-01-01

    Objective The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are multisystem diseases of the small blood vessels. Patients experience irreversible damage and psychological effects from AAV and its treatment. An international collaboration was created to investigate the impact of AAV on health-related quality of life (HRQoL), and develop a disease-specific patient-reported outcome measure to assess outcomes of importance to patients. Methods Patients with AAV from the UK, USA, and Canada were interviewed to identify salient aspects of HRQoL affected by AAV. The study was overseen by a steering committee including four patient research partners. Purposive sampling of interviewees ensured representation of a range of disease manifestations and demographics. Inductive analysis was used to identify themes of importance to patients; these were further confirmed by a free-listing exercise in the US. Individual themes were recast into candidate items, which were scrutinized by patients, piloted through cognitive interviews and received a linguistic and translatability evaluation. Results Fifty interviews, conducted to saturation, with patients from the UK, USA, and Canada, identified 55 individual themes of interest within seven broad domains: general health perceptions, impact on function, psychological perceptions, social perceptions, social contact, social role, and symptoms. Individual themes were constructed into >100 candidate questionnaire items, which were then reduced and refined to 35 candidate items. Conclusion This is the largest international qualitative analysis of HRQoL in AAV to date, and the results have underpinned the development of 35 candidate items for a disease-specific, patient-reported outcome questionnaire. PMID:29379322

  2. Retrofitting Listed Buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2011-01-01

    . The paper demonstrates measures for the improvement of the thermal insulation of the building with solid brick walls. Durable customised measures are shown. The customised measures are required not to change the overall exterior architecture as the building is considered to contribute to the uniqueness......The paper presents a case study where the energy demand for a listed building constructed in 1900 is reduced. Many older buildings are listed and have restrictions that include the entire building or that include only its exterior. For the building presented, only its exterior facade is listed...

  3. Applied building physics

    CERN Document Server

    Hens, Hugo S L C

    2012-01-01

    The energy crises of the 1970s, persisting moisture problems, complaints about sick buildings, thermal, visual and olfactory discomfort, and the move towards more sustainability in building construction have pushed Building Physics to the forefront of building innovation. The societal pressure to diminish energy consumption in buildings without impairing usability acted as a trigger to activate the whole notion of performance based design and construction. As with all engineering sciences, Building Physics is oriented towards application, which is why, after a first book on fundamentals this s

  4. The Erectile Function Visual Analog Scale (EF-VAS): a disease-specific utility instrument for the assessment of erectile function.

    Science.gov (United States)

    Casey, R; Tarride, J E; Keresteci, M A; Torrance, G W

    2006-04-01

    This article presents the responsiveness results of the Erectile Function Visual Analog Scale (EF-VAS) and reports, for the first time, utilities associated with erectile dysfunction (ED), as calculated by a disease-specific utility assessment. The EF-VAS is a new quality of life (QoL) instrument specific to ED that combines the strengths of the disease-specific approach to measuring QoL (greater disease relevance and responsiveness, with relevance to clinicians and patients) with those of preference-based assessments (generalizability and relevance to decision makers). The EF-VAS has demonstrated feasibility, reliability, and validity as reported in a recent publication. Standard instrument development methodology was utilized and the finalized content was integrated into a preference based scoring instrument comprised of two visual analogue scales (VAS). The EF-VAS was implemented in a clinical trial and data from the trial was subjected to validation analysis. Three methods were used to evaluate the responsiveness of the EF-VAS: Spearman correlations, effect size and standardized response means. VAS scores were converted to von Neumann-Morgenstern (vNM) utilities through a conversion curve. The EF-VAS was established to be responsive to changes in disease state within and between patients with ED. The EF-VAS allowed the calculation of vNM utility values and a significant increase in utility was observed in the sildenafil group compared to placebo at study end. The EF-VAS represents an important advance in the understanding of the impact of ED on patients' QoL and in providing a mechanism to allow the quantification of the health status that patients associate with ED. Based on its responsiveness, the EF-VAS will provide an important clinical tool to assess and contribute to the understanding of the impact of treatment for ED. The EF-VAS represents a major advance in the science of health-related quality of life (HRQol) assessment, as it is the first validated ED

  5. Introduction: Green Building Handbook

    CSIR Research Space (South Africa)

    Van Wyk, Llewellyn V

    2010-08-01

    Full Text Available By recognising the specific environmental challenges facing South Africa, mindful of the government‘s commitment to reducing South Africa‘s Greenhouse gas emissions, and acknowledging the need to build social cohesion, the Green Building Handbook...

  6. Buildings interoperability landscape - Draft

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave B. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2015-02-01

    Buildings are an integral part of our nation’s energy economy. The advancement in information and communications technology (ICT) has revolutionized energy management in industrial facilities and large commercial buildings. As ICT costs decrease and capabilities increase, buildings automation and energy management features are transforming the small-medium commercial and residential buildings sectors. A vision of a connected world in which equipment and systems within buildings coordinate with each other to efficiently meet their owners’ and occupants’ needs, and where buildings regularly transact business with other buildings and service providers (such as gas and electric service providers) is emerging. However, while the technology to support this collaboration has been demonstrated at various degrees of maturity, the integration frameworks and ecosystems of products that support the ability to easily install, maintain, and evolve building systems and their equipment components are struggling to nurture the fledging business propositions of their proponents.

  7. Robotic buildings(s)

    NARCIS (Netherlands)

    Bier, H.H.

    2014-01-01

    Technological and conceptual advances in fields such as artificial intelligence, robotics, and material science have enabled robotic building to be in the last decade prototypically implemented. In this context, robotic building implies both physically built robotic environments and robotically

  8. Building the Korogwe Laboratory

    DEFF Research Database (Denmark)

    Knudsen, Jakob; von Seidlein, Lorenz; Richard, Jean Pierre

    2011-01-01

    An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania.......An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania....

  9. Better Buildings Challenge Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-06-01

    The Better Buildings Challenge is a national leadership initiative calling on corporate chief executive officers, university presidents, and state and local leaders to make a significant commitment to building energy efficiency.

  10. Integrated Building Health Management

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract: Building health management is an important part in running an efficient and cost-effective building. Many problems in a building’s system can go undetected...

  11. Building Blueprints: Making Music.

    Science.gov (United States)

    College Planning & Management, 2002

    2002-01-01

    Depicts how Cornell University renovated its civil engineering and architecture building to include space for musical performances, teaching, and rehearsals. The article highlights the facility's contemporary design, which also compliments the form and massing of the original building. (GR)

  12. Building Design & Construction - Sustainability

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-11-01

    Offers a brief history of green building; presents the results of a specially commissioned survey; and analyzes the chief trends, issues, and published research, based on interviews with dozens of experts and participants in green building.

  13. Requirements for existing buildings

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne

    This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....

  14. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...

  15. Library Buildings and Equipment.

    Science.gov (United States)

    Oringdulph, Robert E.; And Others

    1990-01-01

    Six articles discuss library buildings and construction: (1) library buildings and their parts; (2) the North Campus Library of California State University at Long Beach in 1995; (3) new structures for teaching libraries; (4) construction standards for California public libraries; (5) Sick (Library) Building Syndrome; and (6) using focus-group…

  16. Dutch Building Decree

    NARCIS (Netherlands)

    Scholten, N.P.M.

    2000-01-01

    On the 1 October 1992 a change in the Dutch building legislation took effect: the revised Housing Act, the Building Decree and the technical documents related to this legislation came into force. This publication contains an English translation of the Building Decree. In order to give an idea of the

  17. Green Building Research Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sailor, David Jean [Portland State Univ., Portland, OR (United States)

    2013-12-29

    This project provided support to the Green Building Research Laboratory at Portland State University (PSU) so it could work with researchers and industry to solve technical problems for the benefit of the green building industry. It also helped to facilitate the development of PSU’s undergraduate and graduate-level training in building science across the curriculum.

  18. Mobile Platform for Multiplexed Detection and Differentiation of Disease-Specific Nucleic Acid Sequences, Using Microfluidic Loop-Mediated Isothermal Amplification and Smartphone Detection.

    Science.gov (United States)

    Chen, Weili; Yu, Hojeong; Sun, Fu; Ornob, Akid; Brisbin, Ryan; Ganguli, Anurup; Vemuri, Vinay; Strzebonski, Piotr; Cui, Guangzhe; Allen, Karen J; Desai, Smit A; Lin, Weiran; Nash, David M; Hirschberg, David L; Brooks, Ian; Bashir, Rashid; Cunningham, Brian T

    2017-11-07

    New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a platform for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the sensor in conjunction with a hand-held "cradle" that interfaces the phone with a silicon-based microfluidic chip embedded within a credit-card-sized cartridge. Utilizing specific nucleic acid sequences for four equine respiratory pathogens as representative examples, we demonstrated the ability of the system to utilize a single 15 μL droplet of test sample to perform selective positive/negative determination of target sequences, including integrated experimental controls, in approximately 30 min. Our approach utilizes loop-mediated isothermal amplification (LAMP) reagents predeposited into distinct lanes of the microfluidic chip, which when exposed to target nucleic acid sequences from the test sample, generates fluorescent products that when excited by appropriately selected light emitting diodes (LEDs), are visualized and automatically analyzed by a software application running on the smartphone microprocessor. The system achieves detection limits comparable to those obtained by laboratory-based methods and instruments. Assay information is combined with the information from the cartridge and the patient to populate a cloud-based database for epidemiological reporting of test results.

  19. Are generic and disease-specific health related quality of life correlated? The case of chronic lung disease due to sulfur mustard

    Science.gov (United States)

    Assari, Shervin; Lankarani, Maryam Moghani; Montazeri, Ali; Soroush, Mohammad Reza; Mousavi, Batol

    2009-01-01

    BACKGROUND: The aim of this study was to investigate the association between the two most commonly used generic and disease specific health-related quality of life (HRQoL) measures in patients with chronic lung disease due to SM: Medical Outcomes Study Short Form 36-Item (SF-36) and St George's Respiratory Questionnaire (SGRQ). METHODS: This is a secondary analysis of Iranian Chemical Warfare Victims Health Assessment Study (ICWVHAS) during October 2007 in Isfahan, Iran. In that survey, conducted in an outpatient setting, 292 patients with chronic lung disease due to SM were selected from all provinces in Iran. The total score and sub scores of correlations of SGRQ and SF-36 were assessed. Correlation of quality-of-life scores were evaluated using Pearson's coefficient. RESULTS: Samples were 276 patients who were selected for our analysis. No significant correlation was found between the total score or sub scores of SF-36 and the total score or sub scores of SGRQ (p > 0.05). CONCLUSIONS: In patients with chronic lung disease due to SM, the SF-36 and SGRQ assess different aspects of HRQoL. Therefore applying both of them together, at least in the research setting is suggested. PMID:21772897

  20. Effectiveness of disease-specific self-management education on health outcomes in patients with chronic obstructive pulmonary disease: An updated systematic review and meta-analysis.

    Science.gov (United States)

    Wang, Tao; Tan, Jing-Yu; Xiao, Lily Dongxia; Deng, Renli

    2017-08-01

    To update a previously published systematic review on the effectiveness of self-management education (SME) for patients with chronic obstructive pulmonary disease (COPD). Electronic databases were accessed (from inception to July 2016) to find relevant randomized controlled trials. Studies that compared SME with routine methods of care in COPD patients were retrieved. Both data synthesis and descriptive analysis were used for outcome assessment (e.g. quality of life and healthcare utilization). Twenty-four studies were included. Data synthesis showed better quality of life among COPD patients receiving SME. Significant reductions in COPD-related hospital admissions and emergency department visits were identified in the SME group. SME may positively affect the reduction of COPD patients' emotional distress. No significant reduction in smoking rate and mortality rate was observed between groups. No clear evidence supports the improvement of pulmonary functions, dyspnea, and nutritional status in COPD patients with the use of SME. SME can be a useful strategy to improve quality of life and disease-specific knowledge in patients with COPD. It also reduces respiratory-related hospital admissions and emergency department visits in COPD patients. Inclusion of SME as one of the key components for the comprehensive management of COPD is encouraged. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation

    Directory of Open Access Journals (Sweden)

    Toru Oga

    2017-01-01

    Full Text Available Background. Two disease-specific questionnaires have been developed to assess health-related quality of life (HRQL in patients with chronic respiratory failure: the Severe Respiratory Insufficiency (SRI Questionnaire and the Maugeri Respiratory Failure (MRF Questionnaire. We aimed to compare the characteristics of the SRI, MRF-26, and St. George’s Respiratory Questionnaire (SGRQ for use in patients with home noninvasive ventilation (NIV. Methods. Fifty-six outpatients receiving long-term NIV were recruited and underwent assessments of pulmonary function, arterial blood gas, HRQL, dyspnea, and psychological status. Results. Correlations of the SRI and MRF-26 with the SGRQ were modest. While pulmonary function was weakly related to only some domains of the SRI and MRF-26, the modified Medical Research Council (mMRC dyspnea scale and Hospital Anxiety and Depression Scale (HADS were significantly related to all domains of the SRI and MRF-26. Multiple regression analyses showed that HADS depression and mMRC accounted for 34% and 27% of the variance in the SRI, 24% and 37% in the MRF-26, and 17% and 46% in the SGRQ, respectively. Conclusions. The SRI and MRF-26 were reliable questionnaires for patients receiving long-term NIV. Dyspnea and psychological status were their main common determinants. The SRI covers more psychological health impairments than the MRF. This trial is registered with ClinicalTrials.gov Identifier: NCT00905476.

  2. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients.

    Science.gov (United States)

    Ng, Vicky; Nicholas, David; Dhawan, Anil; Yazigi, Nada; Ee, Looi; Stormon, Michael; Gilmour, Susan; Schreiber, Rick; Taylor, Rachel; Otley, Anthony

    2014-09-01

    To develop and validate a Pediatric Liver Transplantation Quality of Life (PeLTQL) questionnaire via an international multicenter collaboration. Item generation with 146 child and/or parent interviews (92 pediatric liver transplantation [LT] recipients) and 3 focus groups generated over 300 items. An item reduction questionnaire with 76 questions was completed by 320 participants (212 pediatric LT recipients). Frequency-importance product ranking, questionnaire formatting, and pre-testing resulted in a 26-item PeLTQL questionnaire. Factor analysis identified 3 domains: future health, coping and adjustment, and social-emotional. The validation phase was completed by 133 (46% male) LT recipients (aged 8-18 years). Internal consistency (Cronbach α = 0.86) and test-retest reliability (intraclass correlation coefficient = 0.85) were excellent. Mean patient PeLTQL score was 69.54 ± 13.06. Construct validity with validated tools identified significant correlations between mean PeLTQL scores and (1) Pediatric Quality of Life Inventory generic (r = 0.64, P valid and reliable novel 26-item disease-specific health related quality of life instrument for LT recipients aged 8-18 years. Low PeLTQL scores can identify patients at risk for childhood anxiety and depression. The tool is now ready for broad use in both clinical practice and clinical interventional trials. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Sustainable Buildings in Interaction

    DEFF Research Database (Denmark)

    Elle, Morten

    2007-01-01

    The first attempts to build sustainable buildings in Denmark were typically located on the countryside. The basic idea was to create buildings that were independent of the technical infrastructure. District heating has, however, been the dominating solution to heating in buildings in Denmark......, and the focus on sustainable building have gradually turned from special houses on the countryside to normally looking houses in the urban fabric, integrated in the technical infrastructure. Some new built urban areas in Denmark will, however, not have to be supplied with district heating – these developments...

  4. Sustainable Building Operation

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    2009-01-01

    Energy-savings in the existing building stock have becomes a main goal in national and international policies. Often focus is on building-renovations, whereas the potential of sustainable building operation to a large extent has been neglected. Nevertheless, international research as well...... as practical experiences from Danish housing estates indicates that there are large potentials for energy savings by focusing on the operation of the buildings. We suggest that in order to achieve sustainability in the existing housing, renovation and operations should be seen as integrated parts...... and that sustainable building operation can pave the way for sustainable building renovation. This paper discusses the use of sustainability building operation in Danish housing estates: Which tools, methods and technologies is being used, where are the barriers and where are the potentials? We define sustainable...

  5. Commercial Buildings Characteristics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-29

    Commercial Buildings Characteristics 1992 presents statistics about the number, type, and size of commercial buildings in the United States as well as their energy-related characteristics. These data are collected in the Commercial Buildings Energy Consumption Survey (CBECS), a national survey of buildings in the commercial sector. The 1992 CBECS is the fifth in a series conducted since 1979 by the Energy Information Administration. Approximately 6,600 commercial buildings were surveyed, representing the characteristics and energy consumption of 4.8 million commercial buildings and 67.9 billion square feet of commercial floorspace nationwide. Overall, the amount of commercial floorspace in the United States increased an average of 2.4 percent annually between 1989 and 1992, while the number of commercial buildings increased an average of 2.0 percent annually.

  6. Validation study of the prototype of a disease-specific index measure for health-related quality of life in dementia

    Directory of Open Access Journals (Sweden)

    Schölzel-Dorenbos Carla J M

    2012-09-01

    Full Text Available Abstract Background Index measures for health-related quality of life (HRQoL quantify the desirability (utility of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific index measures on the other hand combine disease-specificity and quantification of perceived quality on several health domains of a certain disease into one single figure. These instruments have been developed for several diseases, but a dementia-specific HRQoL index instrument was not yet available. Facing the increasing individual and societal burden of dementia, specific HRQoL values with metric characteristics are especially useful because they will provide vital information for health outcome research and economic evaluations. Aims of the study To develop and validate the prototype of a dementia-specific HRQoL index measure: Dementia Quality of life Instrument (DQI, as the first step towards valuation of the dementia health state. Methods For development of the DQI we created a conceptual framework based on a review of the literature, qualitative interviews with people with dementia and their carers, expert opinion and team discussion. To assess validity we undertook a survey under 241 dementia professionals. Measurements consisted of ranking (1–5 and rating (1–10 of 5 dementia-specific DQI domains (memory, orientation, independence, social activities and mood and simultaneously rating of 9 DQI-derived health states on a visual analogue scale (VAS. We also performed a cross-sectional study in a large sample of people with very mild to moderate dementia and their caregivers (N = 145 to assess feasibility and concurrent validity. In addition, caregivers valued 10 DQI and 10 EQ-5D + C derived health states of the patient simultaneously on the same VAS. Setting: outpatient clinics, nursing homes and patient residences. Results All

  7. High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population

    Directory of Open Access Journals (Sweden)

    Takata Y

    2013-06-01

    Full Text Available Yutaka Takata,1 Toshihiro Ansai,2 Inho Soh,2 Shuji Awano,2 Ikuo Nakamichi,1 Sumio Akifusa,3 Kenichi Goto,1 Akihiro Yoshida,2 Hiroki Fujii,1 Ritsuko Fujisawa,1 Kazuo Sonoki31Division of General Internal Medicine, 2Division of Community Oral Health Science, 3Department of Oral Health and Environment, School of Oral Health Science, Kyushu Dental University, Kitakyushu, JapanBackground: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population.Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan’s Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity.Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899–0.978, P = 0.003 with each one-point increase in participants’ scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one

  8. The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance.

    Science.gov (United States)

    Frederix, Gerardus W J; van Hasselt, Johan G C; Schellens, Jan H M; Hövels, Anke M; Raaijmakers, Jan A M; Huitema, Alwin D R; Severens, Johan L

    2014-01-01

    from 0.207 to 0.356 years, while incremental costs ranged from €3,490 to €3,714 and ICERs ranged from €9,804/LYG to €17,966/LYG. When we re-analyzed the published CEAs in our framework by including their respective model properties, the LYG ranged from 0.207 to 0.383 years, IC ranged from €3,556 to €3,731 and ICERs ranged from €9,683/LYG to €17,570/LYG. Differences in model structure and parameterization lead to substantial differences in analysis outcome metrics. This analysis supports the need for more guidance regarding structural uncertainty and the use of standardized disease-specific models for health economic analyses of adjuvant endocrine breast cancer therapies. The developed approach in the current analysis could potentially serve as a template for further evaluations of structural uncertainty and development of disease-specific models.

  9. Health-related quality of life in ANCA-associated vasculitis and item generation for a disease-specific patient-reported outcome measure

    Directory of Open Access Journals (Sweden)

    Robson JC

    2018-01-01

    -related quality of life (HRQoL, and develop a disease-specific patient-reported outcome measure to assess outcomes of importance to patients.Methods: Patients with AAV from the UK, USA, and Canada were interviewed to identify salient aspects of HRQoL affected by AAV. The study was overseen by a steering committee including four patient research partners. Purposive sampling of interviewees ensured representation of a range of disease manifestations and demographics. Inductive analysis was used to identify themes of importance to patients; these were further confirmed by a free-listing exercise in the US. Individual themes were recast into candidate items, which were scrutinized by patients, piloted through cognitive interviews and received a linguistic and translatability evaluation.Results: Fifty interviews, conducted to saturation, with patients from the UK, USA, and Canada, identified 55 individual themes of interest within seven broad domains: general health perceptions, impact on function, psychological perceptions, social perceptions, social contact, social role, and symptoms. Individual themes were constructed into >100 candidate questionnaire items, which were then reduced and refined to 35 candidate items.Conclusion: This is the largest international qualitative analysis of HRQoL in AAV to date, and the results have underpinned the development of 35 candidate items for a disease-specific, patient-reported outcome questionnaire. Keywords: ANCA-associated vasculitis, quality of life, patient-reported outcomes, granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis

  10. Sleep disturbance in Moroccan patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status and quality of life.

    Science.gov (United States)

    Hakkou, Jinane; Rostom, Samira; Mengat, Mariam; Aissaoui, Nawal; Bahiri, Rachid; Hajjaj-Hassouni, Najia

    2013-02-01

    Sleep disturbance is often reported by the patients with ankylosing spondylitis (AS), with awakenings produced by inflammatory pain. There are limited studies about sleep disturbance on these patients, and especially its association with psychological state and quality of life to examine the prevalence of sleep disturbance and to assess its association with disease-specific variables, psychological status and quality of life. One hundred and ten patients were included in this cross-sectional study according to the modified New York criteria for AS. Clinical and biological parameters were evaluated. Sleep disturbance was assessed by the fourth item of Hamilton Anxiety Scale. Psychological status was assessed by The Hospital Anxiety and Depression Scale including depression subscale and anxiety subscale. The quality of life was evaluated by the short form-36 (SF-36). Sleep disturbance was found in 64.5 %, depression in 55.5 % and anxiety in 60.9 % amongst our patients. Significantly, worse pain, higher disease activity and functional disability were present in patients with sleep disturbance. Likewise, sleep problems were significantly higher in patients with depression, anxiety and in patients with low scores of the SF36. Multivariate logistic regression analysis revealed that the pain (OR = 1.019) and depression (OR = 1.304) were independent risk factors that influenced sleep disturbance. Sleep problems are prevalent amongst Moroccan patients with AS. Our findings suggest that pain and depression were the independent risk factors that influenced the sleep disturbance and hence, the need for evaluation and optimal management of pain and depression to improve sleep quality in AS patients.

  11. Disease-specific direct-to-consumer advertising of pharmaceuticals: An examination of endorser type and gender effects on consumers' attitudes and behaviors.

    Science.gov (United States)

    Bhutada, Nilesh S; Rollins, Brent L

    2015-01-01

    Direct-to-consumer (DTC) advertising is still a controversial topic for pharmaceutical manufacturers' and researchers, and while numerous studies have examined the DTC phenomenon, little research has examined the effect of gender, particularly gender of the endorser and consumer. The objective of this research was to assess the impact of the endorser (celebrity vs. expert vs. non-celebrity) and gender - both gender of the endorser and gender of the consumer - on consumers' attitudes and behaviors in response to a print disease-specific direct-to-consumer advertisement. Using Qualtrics consumer panel, data were obtained for 514 US adults (age 18 years and above) who demonstrated at least minimal symptoms of depression and need for monitoring based on the Patient Health Questionnaire (PHQ) score. Data were analyzed using a 3 (Endorser Type: Celebrity/Expert/Non-Celebrity) × 2 (Endorser Gender: Male/Female) × 2 (Consumer Gender: Male/Female) full factorial between subjects multivariate analysis of variance (MANOVA) and necessary univariate analysis. Only the type of the endorser (celebrity vs. expert vs. non-celebrity) used in the ad had a significant main effect on the dependent variables. Further univariate analyses revealed that, of the several dependent variables, endorser type had a significant influence only on attitude towards the ad, attention paid to the ad, and endorser credibility, with gender being non-significant in all cases. Expert endorser generated significantly more favorable levels of attitude towards the ad, and endorser credibility compared to the non-celebrity endorser. Celebrity endorser attracted more consumer attention towards the ad and generated favorable endorser credibility perceptions compared to the non-celebrity endorser. However, celebrity and expert endorsers did not significantly differ from each other on the abovementioned ad effectiveness variables. Lastly, endorser gender and consumer gender did not have a significant influence

  12. Effect of clinical and laboratory parameters on quality of life in celiac patients using celiac disease-specific quality of life scores.

    Science.gov (United States)

    Lee, Jungmin; Clarke, Kofi

    2017-11-01

    Health-related quality of life (HR-QOL) in patients with celiac disease is reduced compared to the general population. We investigated the association between HR-QOL and clinical, laboratory findings using the previously validated CD-QOL (celiac disease-specific quality of life) instrument in patients with celiac disease. To our knowledge, no study has previously explored the relationship between HR-QOL and clinical, laboratory parameters in celiac patients. Patients who received care at the Allegheny Health Network Celiac Center, Pittsburgh, PA were asked to complete the CD-QOL questionnaire. A cross sectional study with predetermined clinical and laboratory parameters was performed. Data collected included IgA anti-tissue transglutaminase (tTG) antibody titers, iron studies, calcium, vitamin A, B12, 25 OH vitamin D, and E levels. Correlation between clinical findings and CD-QOL was also assessed. Seventy-eight out of 124 patients who completed the questionnaire was included in the analysis. Patients with concomitant irritable bowel syndrome (IBS) had significantly reduced HR-QOL with CD-QOL score of 52.4 ± 11.3 vs. 44.6 ± 12.9 in those without IBS (p = .009). There was no difference in HR-QOL in relation to IgA tTG titers or vitamin D levels. Of note, there was a trend towards correlation between higher level of vitamin E and better QOL (r = -0.236, p = .074). Celiac patients with concomitant IBS have reduced HR-QOL. There was no statistically significant association between HR-QOL and laboratory parameters or levels of micronutrients.

  13. Development and validation of a disease-specific health-related quality of life measure, the LupusQol, for adults with systemic lupus erythematosus.

    Science.gov (United States)

    McElhone, Kathleen; Abbott, Janice; Shelmerdine, Joanna; Bruce, Ian N; Ahmad, Yasmeen; Gordon, Caroline; Peers, Kate; Isenberg, David; Ferenkeh-Koroma, Ada; Griffiths, Bridget; Akil, Mohamed; Maddison, Peter; Teh, Lee-Suan

    2007-08-15

    To develop and validate a disease-specific health-related quality of life (HRQOL) instrument for adults with systemic lupus erythematosus (SLE). The work consisted of 6 stages. Stage 1 included item generation for questionnaire content from semistructured interviews with SLE patients. In stage 2 item selection for the draft questionnaire was performed by thematic analysis of the patient interview transcripts and expert panel agreement. In stage 3 the content validity of the draft questionnaire was assessed by patients completing the questionnaire and providing critical feedback. In stages 4 and 5 construct validity and internal reliability of the 3 versions of the LupusQoL were evaluated using principal component analysis with varimax rotation and Cronbach's alpha coefficients, respectively. In stage 6 discriminatory validity, concurrent validity, and test-retest reliability were evaluated. Stages 1, 2, and 3 resulted in a preliminary instrument containing 63 items. In stage 4, 8 domains were identified. This factor structure, accounting for 82% of the variance, was confirmed in stage 5. The domains and Cronbach's alpha coefficients were physical health (0.94), emotional health (0.94), body image (0.89), pain (0.92), planning (0.93), fatigue (0.88), intimate relationships (0.96), and burden to others (0.94). Discriminant validity was demonstrated for different levels of disease activity (British Isles Lupus Assessment Group Index) and damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index). High correlations (r = 0.71-0.79) between comparable domains of the Short Form 36 and the LupusQoL assured acceptable concurrent validity. Good test-retest reliability (r = 0.72-0.93) was demonstrated. The LupusQoL is a validated SLE-specific HRQOL instrument with 34 items across 8 domains defined by patients as being important.

  14. Pretreatment tumor SUV{sub max} predicts disease-specific and overall survival in patients with head and neck soft tissue sarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Seung Cheol; Roh, Jong-Lyel; Choi, Seung-Ho; Nam, Soon Yuhl; Kim, Sang Yoon [University of Ulsan College of Medicine, Departments of Otolaryngology, Asan Medical Center, Songpa-gu, Seoul (Korea, Republic of); Oh, Jungsu S.; Moon, Hyojeong; Kim, Jae Seung [University of Ulsan College of Medicine, Departments of Nuclear Medicine, Asan Medical Center, Seoul (Korea, Republic of); Cho, Kyung-Ja [University of Ulsan College of Medicine, Departments of Pathology, Asan Medical Center, Seoul (Korea, Republic of)

    2017-01-15

    Head and neck soft tissue sarcoma (HNSTS) is a rare type of tumor with various histological presentations and clinical behaviors. {sup 18}F-FDG PET/CT is being increasingly used for staging, grading, and predicting treatment outcomes in various types of human cancers, although this modality has been rarely studied in the survival prediction of HNSTS. Here we examined the prognostic value of tumor metabolic parameters measured using {sup 18}F-FDG PET/CT in patients with HNSTS. This study included 36 consecutive patients with HNSTS who underwent {sup 18}F-FDG PET/CT scanning prior to treatment at our institution. Tumor gross total volume (GTV) was measured from pretreatment contrast-enhanced CT scans, and maximum standardized uptake value (SUV{sub max}), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using pretreatment {sup 18}F-FDG PET/CT scans. Univariate and multivariate Cox proportional hazard regression analyses were used to identify associations between imaging parameters and disease-specific survival (DSS) or overall survival (OS). Univariate analyses showed that SUV{sub max}, MTV, and TLG, but not GTV, were significantly associated with DSS and OS (all P < 0.05). After controlling for clinicopathological factors, SUV{sub max}, MTV, and TLG were significantly associated with DSS and OS (all P < 0.05). Patients with a tumor SUV{sub max} value of >7.0 experienced an approximately fivefold increase in mortality in terms of DSS and OS relative to those with a tumor SUV{sub max} <7.0. Quantitative metabolic measurements on pretreatment {sup 18}F-FDG PET/CT can yield values that are significantly predictive of survival after treatment for HNSTS. (orig.)

  15. Perfusion Parameters on Breast Dynamic Contrast-Enhanced MRI Are Associated With Disease-Specific Survival in Patients With Triple-Negative Breast Cancer.

    Science.gov (United States)

    Park, Vivian Youngjean; Kim, Eun-Kyung; Kim, Min Jung; Yoon, Jung Hyun; Moon, Hee Jung

    2017-03-01

    The aim of this study was to investigate the association between perfusion parameters on MRI performed before treatment and survival outcome (disease-free survival [DFS], disease-specific survival [DSS]) in patients with triple-negative breast cancer (TNBC). Sixty-one patients (median age, 50 years; age range, 27-77 years) with TNBC (tumor size on MRI: median, 25.5 mm; range, 11.0-142.0 mm) were included. We analyzed clinical and pathologic variables and MRI parameters. Cox proportional hazards models were used to determine associations with survival outcome. The median follow-up time was 46.1 months (range, 13.9-58.4 months). Eleven of 61 (18.0%) patients had events (i.e., local, regional, or distant recurrence or contralateral breast cancer) and seven (11.5%) died of breast cancer. Among the pretreatment variables, a larger tumor size on MR images (hazard ratio [HR] = 1.024, p = 0.003) was associated with worse DFS at univariate analysis. In multivariate pretreatment models for DSS, a higher fractional volume of extravascular extracellular space per unit volume of tissue (ve) value (HR = 1.658, p = 0.038), higher peak enhancement (HR = 1.843, p = 0.018), and a larger tumor size on MR images (HR = 1.060, p = 0.001) were associated with worse DSS. In multivariate posttreatment models, a larger pathologic tumor size (HR for DFS, 1.074 [p = 0.005]; HR for DSS, 1.050 [p = 0.042]) and metastasis in surgically resected axillary lymph nodes (HR for DFS, 5.789 [p = 0.017]; HR for DSS, 23.717 [p = 0.005]) were associated with worse survival outcome. A higher ve value, higher peak enhancement, and larger tumor size of the primary tumor on pretreatment MRI were independent predictors of worse DSS in patients with TNBC.

  16. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Kenichi eOishi

    2011-08-01

    Full Text Available Background: Alterations of the gray and white matter have been identified in Alzheimer’s disease (AD by structural MRI and diffusion tensor imaging (DTI. However, whether the combination of these modalities could increase the diagnostic performance is unknown.Methods: Participants included 19 AD patients, 22 amnestic mild cognitive impairment (aMCI patients, and 22 cognitively normal elderly (NC. The aMCI group was further divided into an aMCI-converter group (converted to AD dementia within three years, and an aMCI-stable group who did not convert in this time period. A T1-weighted image, a T2 map, and a DTI of each participant were normalized, and voxel-based comparisons between AD and NC groups were performed. Regions-of-interest, which defined the areas with significant differences between AD and NC, were created for each modality and named disease-specific spatial filters (DSF. Linear discriminant analysis was used to optimize the combination of multiple MRI measurements extracted by DSF to effectively differentiate AD from NC. The resultant DSF and the discriminant function were applied to the aMCI group to investigate the power to differentiate the aMCI-converters from the aMCI-stable patients. Results: The multi-modal approach with AD-specific filters led to a predictive model with an area under the receiver operating characteristic curve (AUC of 0.93, in differentiating aMCI-converters from aMCI-stable patients. This AUC was better than that of a single-contrast-based approach, such as T1-based morphometry or diffusion anisotropy analysis. Conclusion: The multi-modal approach has the potential to increase the value of MRI in predicting conversion from aMCI to AD.

  17. Utility of the APACHE IV, PPI, and combined APACHE IV with PPI for predicting overall and disease-specific ICU and ACU mortality.

    Science.gov (United States)

    Burkmar, Jennifer A; Iyengar, Rajesh

    2011-08-01

    The Acute Physiology and Chronic Health Evaluation (APACHE) IV and Palliative Performance Index (PPI) are scales commonly used to assess prognosis in intensive care units (ICUs) and acute care units (ACUs). To compare the utility of APACHE IV, PPI, and combined APACHE IV with PPI for predicting overall and disease-specific mortality. This is a prospective cohort study using admission data during the first 24 hours. Chi-square contingency tables were used to analyze mortality data for each scale. This study was conducted at a community hospital. Participants were admitted between December 24, 2008 and April 2, 2010. The APACHE IV, PPI, and APACHE IV plus PPI (n = 599) were significant for predicting overall mortality (P APACHE IV was also significant in predicting mortality in patients with congestive heart failure (CHF), pulmonary edema (PULEDEM), stroke (cerebrovascular accident [CVA]), terminal or metastatic cancer (CA), and dementia. The PPI was significant for predicting mortality in PULEDEM, CA, and dementia but not CVA or CHF, while the APACHE IV with PPI was significant for all diseases but CVA. The APACHE IV was the most robust in predicting ICU/ACU mortality. The combined APACHE IV and PPI improved the specificity of the PPI to predict mortality but caused a decline in sensitivity. Limitations are due to the subjective nature of the PPI and Glasgow Coma scale (GCS), differences in illness trajectories, and a lack of reliable follow-up of all participants. The benefits of combining scales were best exemplified in participants with dementia. Inconsistencies in the predictive value of specific participant populations are likely due to difference in the illness trajectories of disease processes.

  18. Characterization of the Wilson disease gene: Genomic organization; alternative splicing; structure/function predictions; and population frequencies of disease-specific mutations

    Energy Technology Data Exchange (ETDEWEB)

    Petrukhin, K.; Chernov, I.; Ross, B.M. [Columbia Univ., New York, NY (United States)] [and others

    1994-09-01

    The Wilson disease (WD) gene has recently been identified as a putative copper-transporting ATPase with high amino acid similarity with the Menkes disease (MNK) gene. We have further characterized the WD gene by extending the 5{prime}-coding and non-coding DNA sequence and elucidating the intron/exon structure and genomic organization. Analysis of RNA transcripts from liver, brain, kidney and placenta reveals extensive alternative splicing which may provide a mechanism to regulate the quantity of functional protein product. Comparative sequence analysis shows that WD and MNK belong to the sub-family of heavy metal-transporting ATPases with several characterizing features which include unique amino acid motifs and distinct N-terminal and C-terminal transmembrane structure. Our data indicate that the 600 amino acid metal binding portion of the WD and MNK proteins was formed by gene duplication events and splicing of the 6 metal binding domain segment to a common ancestral protein. We have raised a WD-specific anti-peptide antibody to the N-terminal region and are beginning to explore the cellular and intracellular location of the WD protein. The metal-binding segment of the WD protein has been expressed in E. coli and metal binding assays are underway to characterize this aspect of the protein`s function. We have identified numerous disease-specific mutations and developed a rapid {open_quotes}reverse dot blot{close_quotes} screening protocol to determine mutation frequencies in different populations. The most common mutation disrupts the characteristic SEHP motif and accounts for more than 40% of WD cases in North American, Russian, and Swedish populations. This mutation has not been observed in our limited Sicilian sample.

  19. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer's disease.

    Science.gov (United States)

    Oishi, Kenichi; Akhter, Kazi; Mielke, Michelle; Ceritoglu, Can; Zhang, Jiangyang; Jiang, Hangyi; Li, Xin; Younes, Laurent; Miller, Michael I; van Zijl, Peter C M; Albert, Marilyn; Lyketsos, Constantine G; Mori, Susumu

    2011-01-01

    Alterations of the gray and white matter have been identified in Alzheimer's disease (AD) by structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). However, whether the combination of these modalities could increase the diagnostic performance is unknown. Participants included 19 AD patients, 22 amnestic mild cognitive impairment (aMCI) patients, and 22 cognitively normal elderly (NC). The aMCI group was further divided into an "aMCI-converter" group (converted to AD dementia within 3 years), and an "aMCI-stable" group who did not convert in this time period. A T(1)-weighted image, a T(2) map, and a DTI of each participant were normalized, and voxel-based comparisons between AD and NC groups were performed. Regions-of-interest, which defined the areas with significant differences between AD and NC, were created for each modality and named "disease-specific spatial filters" (DSF). Linear discriminant analysis was used to optimize the combination of multiple MRI measurements extracted by DSF to effectively differentiate AD from NC. The resultant DSF and the discriminant function were applied to the aMCI group to investigate the power to differentiate the aMCI-converters from the aMCI-stable patients. The multi-modal approach with AD-specific filters led to a predictive model with an area under the receiver operating characteristic curve (AUC) of 0.93, in differentiating aMCI-converters from aMCI-stable patients. This AUC was better than that of a single-contrast-based approach, such as T(1)-based morphometry or diffusion anisotropy analysis. The multi-modal approach has the potential to increase the value of MRI in predicting conversion from aMCI to AD.

  20. Control of Pathogenicity and Disease Specificity of a T-Lymphomagenic Gammaretrovirus by E-Box Motifs but Not by an Overlapping Glucocorticoid Response Element▿

    Science.gov (United States)

    Ejegod, Ditte; Sørensen, Karina Dalsgaard; Mossbrugger, Ilona; Quintanilla-Martinez, Leticia; Schmidt, Jörg; Pedersen, Finn Skou

    2009-01-01

    Although transcription factors of the basic helix-loop-helix family have been shown to regulate enhancers of lymphomagenic gammaretroviruses through E-box motifs, the overlap of an E-box motif (Egre) with the glucocorticoid response element (GRE) has obscured their function in vivo. We report here that Egre, but not the GRE, affects disease induction by the murine T-lymphomagenic SL3-3 virus. Mutating all three copies of Egre prolonged the tumor latency period from 60 to 109 days. Further mutating an E-box motif (Ea/s) outside the enhancer prolonged the latency period to 180 days, suggesting that Ea/s works as a backup site for Egre. While wild-type SL3-3 and GRE and Ea/s mutants exclusively induced T-cell lymphomas with wild-type latencies mainly of the CD4+ CD8− phenotype, Egre as well as the Egre and Ea/s mutants induced B-cell lymphomas and myeloid leukemia in addition to T-cell lymphomas. T-cell lymphomas induced by the two Egre mutants had the same phenotype as those induced by wild-type SL3-3, indicating the incomplete disruption of T-cell lymphomagenesis, which is in contrast to previous findings for a Runx site mutant of SL3-3. Mutating the Egre site or Egre and Ea/s triggered several tumor phenotype-associated secondary enhancer changes encompassing neighboring sites, none of which led to the regeneration of an E-box motif. Taken together, our results demonstrate a role for the E-box but not the GRE in T lymphomagenesis by SL3-3, unveil an inherent broader disease specificity of the virus, and strengthen the notion of selection for more potent enhancer variants of mutated viruses during tumor development. PMID:18945767

  1. Green Building Tools for Tribes

    Science.gov (United States)

    Tribal green building tools and funding information to support tribal building code adoption, healthy building, siting, energy efficiency, renewable energy, water conservation, green building materials, recycling and adaptation and resilience.

  2. The Building Design Advisor

    Energy Technology Data Exchange (ETDEWEB)

    Papamichael, K.; LaPorta, J.; Chauvet, H.; Collins, D.; Trzcinski, T.; Thorpe, J.; Selkowitz, S.

    1996-03-01

    The Building Design Advisor (BDA) is a software environment that supports the integrated use of multiple analysis and visualization tools throughout the building design process, from the initial, schematic design phases to the detailed specification of building components and systems. Based on a comprehensive design theory, the BDA uses an object-oriented representation of the building and its context, and acts as a data manager and process controller to allow building designers to quickly navigate through the multitude of descriptive and performance parameters addressed by the analysis and visualization tools linked to the BDA. Through the Browser the user can edit the values of input parameters and select any number of input and/or output parameters for display in the Decision Desktop. The Desktop allows building designers to compare multiple design alternatives with respect to any number of parameters addressed by the tools linked to the BDA.

  3. Green buildings pay

    DEFF Research Database (Denmark)

    Naboni, Emanuele; Edwards, Brian

    a number of LEED and BREEAM cases the buildings which flow from corporate environmental responsibility. A number of office and university buildings are examined from three main perspectives- the architect, client and user. One key finding is that architectural innovation has been driven by ecological...... or environmental thinking and this finds expression in new approaches to the design of building facades, roofs, atria. Another is that new software simulation tools have changed energy assumptions and hence building forms. In a fast evolving arena, the book shows how architects are reshaping their practices...... to deal with ever more demanding energy standards and better informed users and corporate clients. A key theme of the book is that of productivity and performance of both the building and its users. The buildings examined and the interviews conducted seek to compare practice in Europe with that of the USA...

  4. Sick building syndrome

    OpenAIRE

    Tjandra Y. Aditama; Sita L. Andarini

    2002-01-01

    Sick building syndrome describes a number of mostly unspesific complaints of some occupants of the building. The exact pathophysiological mechanism remains elusive. It is a multi factorial event which may include physical, chemical, biological as well as psycological factors. In many cases it is due to insufficient maintenance of the HVAC (heating, ventilation, air conditioning) system in the building. Sign and symptoms can be uncomfortable and even disabling, which may include mucus membrane...

  5. Development of Ecological Buildings

    Directory of Open Access Journals (Sweden)

    Andrius Keizikas

    2011-04-01

    Full Text Available The article presents research on ecological buildings and their influence on the constructional sphere. The aim of the paper is to reveal the essence of ecological architecture showing substantial progress and its potential to stimulate architectural and technological growth. The article also describes relations between the ideas of ecological buildings and the ‘passive house’ concepts and aspects of development as well as describes the possibilities of improving building sustainability and energy efficiency. Article in Lithuanian

  6. Trends in building materials

    CSIR Research Space (South Africa)

    Mapiravana, Joseph

    2012-07-01

    Full Text Available of light-weight ultra-high performance concretes, Portland cement replacement, cement matrix and polymer matrix composites, recycling and reuse of waste materials, smart building materials, nanotechnology materials, green energy efficient building... on cement and concrete, composites, waste recycling and reuse and recently nanotechnology materials. To significantly impact on cost reduction and delivery lead time, it is recommended that building materials research and development priorities...

  7. Heritage Building Information Modelling

    OpenAIRE

    Arayici, Y; Mahdjoubi, L.; Counsell, J

    2017-01-01

    This book is about Heritage Building Information Modelling (HBIM). This is a term that has only begun to be used in the latter part of the last decade, since Building Information Modelling (BIM) superseded 3D digital modelling and computer aided design (CAD) as the term generally used to describe the use of information and communication technology (ICT) for the design, construction, and procurement of the modern built environment. It is sometimes also defined as Historic Building Information ...

  8. Building valve amplifiers

    CERN Document Server

    Jones, Morgan

    2013-01-01

    Building Valve Amplifiers is a unique hands-on guide for anyone working with tube audio equipment--as an electronics hobbyist, audiophile or audio engineer. This 2nd Edition builds on the success of the first with technology and technique revisions throughout and, significantly, a major new self-build project, worked through step-by-step, which puts into practice the principles and techniques introduced throughout the book. Particular attention has been paid to answering questions commonly asked by newcomers to the world of the valve, whether audio enthusiasts tackling their first build or

  9. Building Thermal Models

    Science.gov (United States)

    Peabody, Hume L.

    2017-01-01

    This presentation is meant to be an overview of the model building process It is based on typical techniques (Monte Carlo Ray Tracing for radiation exchange, Lumped Parameter, Finite Difference for thermal solution) used by the aerospace industry This is not intended to be a "How to Use ThermalDesktop" course. It is intended to be a "How to Build Thermal Models" course and the techniques will be demonstrated using the capabilities of ThermalDesktop (TD). Other codes may or may not have similar capabilities. The General Model Building Process can be broken into four top level steps: 1. Build Model; 2. Check Model; 3. Execute Model; 4. Verify Results.

  10. Sick building syndrome

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2002-06-01

    Full Text Available Sick building syndrome describes a number of mostly unspesific complaints of some occupants of the building. The exact pathophysiological mechanism remains elusive. It is a multi factorial event which may include physical, chemical, biological as well as psycological factors. In many cases it is due to insufficient maintenance of the HVAC (heating, ventilation, air conditioning system in the building. Sign and symptoms can be uncomfortable and even disabling, which may include mucus membrane irritation, neurotoxic symptoms, asthma like symptoms, skin complaints, gastrointestinal symptoms and other related symptoms. There are various investigation methods to diagnose sick building syndrome, and on site assessment of the building is extremely useful. Prevention through a proactive air quality monitoring program is far more desirable than dealing with an actual sick building. Indoor air and the sick building symdrome serves as a paradigm of modern occupational and environmental medicine. (Med J Indones 2002; 11:124-31Keywords: indoor air pollution, sick building syndrome, building related illness

  11. Building performance modelling for sustainable building design

    Directory of Open Access Journals (Sweden)

    Olufolahan Oduyemi

    2016-12-01

    The output revealed that BPM delivers information needed for enhanced design and building performance. Recommendations such as the establishment of proper mechanisms to monitor the performance of BPM related construction are suggested to allow for its continuous implementation. This research consolidates collective movements towards wider implementation of BPM and forms a base for developing a sound BIM strategy and guidance.

  12. Can a disease-specific education program augment self-management skills and improve Health-Related Quality of Life in people with hip or knee osteoarthritis?

    Directory of Open Access Journals (Sweden)

    Buchbinder Rachelle

    2006-11-01

    Full Text Available Abstract Background Patient education and self-management programs are offered in many countries to people with chronic conditions such as osteoarthritis (OA. The most well-known is the disease-specific Stanford Arthritis Self-Management Program (ASMP. While Australian and international clinical guidelines promote the concept of self-management for OA, there is currently little evidence to support the use of the ASMP. Several meta-analyses have reported that arthritis self-management programs had minimal or no effect on reducing pain and disability. However, previous studies have had methodological shortcomings including the use of outcome measures which do not accurately reflect program goals. Additionally, limited cost-effectiveness analyses have been undertaken and the cost-utility of the program has not been explored. Methods/design This study is a randomised controlled trial to determine the efficacy (in terms of Health-Related Quality of Life and self-management skills and cost-utility of a 6-week group-based Stanford ASMP for people with hip or knee OA. Six hundred participants referred to an orthopaedic surgeon or rheumatologist for hip or knee OA will be recruited from outpatient clinics at 2 public hospitals and community-based private practices within 2 private hospital settings in Victoria, Australia. Participants must be 18 years or over, fluent in English and able to attend ASMP sessions. Exclusion criteria include cognitive dysfunction, previous participation in self-management programs and placement on a waiting list for joint replacement surgery or scheduled joint replacement. Eligible, consenting participants will be randomised to an intervention group (who receive the ASMP and an arthritis self-management book or a control group (who receive the book only. Follow-up will be at 6 weeks, 3 months and 12 months using standardised self-report measures. The primary outcome is Health-Related Quality of Life at 12 months, measured

  13. Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods.

    Science.gov (United States)

    Jansson, Sven-Arne; Heibert-Arnlind, Marianne; Middelveld, Roelinde Jm; Bengtsson, Ulf J; Sundqvist, Ann-Charlotte; Kallström-Bengtsson, Ingrid; Marklund, Birgitta; Rentzos, Georgios; Åkerström, Johanna; Östblom, Eva; Dahlén, Sven-Erik; Ahlstedt, Staffan

    2013-01-01

    Our aim was to investigate the factors that affect health related quality of life (HRQL) in adult Swedish food allergic patients objectively diagnosed with allergy to at least one of the staple foods cow's milk, hen's egg or wheat. The number of foods involved, the type and severity of symptoms, as well as concomitant allergic disorders were assessed. The disease-specific food allergy quality of life questionnaire (FAQLQ-AF), developed within EuroPrevall, was utilized. The questionnaire had four domains: Allergen Avoidance and Dietary Restrictions (AADR), Emotional Impact (EI), Risk of Accidental Exposure (RAE) and Food Allergy related Health (FAH). Comparisons were made with the outcome of the generic questionnaire EuroQol Health Questionnaire, 5 Dimensions (EQ-5D). The patients were recruited at an outpatient allergy clinic, based on a convincing history of food allergy supplemented by analysis of specific IgE to the foods in question. Seventy-nine patients participated (28 males, 51 females, mean-age 41 years). The domain with the most negative impact on HRQL was AADR, assessing the patients' experience of dietary restrictions. The domain with the least negative impact on HRQL was FAH, relating to health concerns due to the food allergy. One third of the patients had four concomitant allergic disorders, which had a negative impact on HRQL. Furthermore, asthma in combination with food allergy had a strong impact. Anaphylaxis, and particularly prescription of an epinephrine auto-injector, was associated with low HRQL. These effects were not seen using EQ-5D. Analyses of the symptoms revealed that oral allergy syndrome and cardiovascular symptoms had the greatest impact on HRQL. In contrast, no significant effect on HRQL was seen by the number of food allergies. The FAQLQ-AF is a valid instrument, and more accurate among patients with allergy to staple foods in comparison to the commonly used generic EQ-5D. It adds important information on HRQL in food allergic

  14. The role of personality in the course of health-related quality of life and disease-specific health status among colorectal cancer survivors: A prospective population-based study from the PROFILES registry

    NARCIS (Netherlands)

    Husson, O.; Vissers, P.A.; Denollet, J.; Mols, F.

    2015-01-01

    BACKGROUND: Prospective studies in various cardiovascular populations show that Type D personality predicted impaired health-related quality of life (HRQoL) and disease-specific health status. We examined the effect of negative affectivity (NA), social inhibition (SI) and their combined effect (Type

  15. Building a Better Robot

    Science.gov (United States)

    Navah, Jan

    2012-01-01

    Kids love to build robots, letting their imaginations run wild with thoughts of what they might look like and what they could be programmed to do. Yet when students use cereal boxes and found objects to make robots, often the projects look too similar and tend to fall apart. This alternative allows students to "build" robots in a different way,…

  16. The sick building syndrome

    OpenAIRE

    Joshi Sumedha

    1985-01-01

    The sick building syndrome comprises of various nonspecific symptoms that occur in the occupants of a building. This feeling of ill health increases sickness absenteeism and causes a decrease in productivity of the workers. As this syndrome is increasingly becoming a major occupational hazard, the cause, management and prevention of this condition have been discussed in this article.

  17. The sick building syndrome.

    Science.gov (United States)

    Joshi, Sumedha M

    2008-08-01

    The sick building syndrome comprises of various nonspecific symptoms that occur in the occupants of a building. This feeling of ill health increases sickness absenteeism and causes a decrease in productivity of the workers. As this syndrome is increasingly becoming a major occupational hazard, the cause, management and prevention of this condition have been discussed in this article.

  18. Heat loss from Buildings

    DEFF Research Database (Denmark)

    Karlsson, Kenneth; Næraa, Rikke

    1997-01-01

    Determination of heat loss coefficients for buildings in Denmark. The coefficient are determined for 15 building groups and 3 year intervals. They are based on the BBR-registre and assumptions of U-values(W/K*m2)and computed in a simple spreed sheet model.The results are used in the REVEILLE...

  19. Building a Data Warehouse.

    Science.gov (United States)

    Levine, Elliott

    2002-01-01

    Describes how to build a data warehouse, using the Schools Interoperability Framework (www.sifinfo.org), that supports data-driven decision making and complies with the Freedom of Information Act. Provides several suggestions for building and maintaining a data warehouse. (PKP)

  20. Reusing Old Manufacturing Buildings

    Science.gov (United States)

    Roman, Harry T.

    2014-01-01

    This article presents an interesting design challenge for students, one that will certainly let them integrate subject matter and get a sense of pride for doing something useful in their own community. The author would be willing to bet that the average town or city has some old red brick manufacturing building(s) that have seen much better days.…

  1. COLLAPSED BUILDINGS IN NIGERIA

    African Journals Online (AJOL)

    Global Journal

    2016-05-23

    May 23, 2016 ... STRUCTURAL. FAILURES. Ajayi (1988) has attributed building failures and collapse in Nigeria to poor design of structure and foundation detailing. ... contributors to structural failures in buildings. ... A. E. Archibong, Department of Architecture, Cross River University of Technology, Calabar, Nigeria.

  2. Building Global Learning Communities

    Science.gov (United States)

    Cochrane, Thomas; Buchem, Ilona; Camacho, Mar; Cronin, Catherine; Gordon, Averill; Keegan, Helen

    2013-01-01

    Within the background where education is increasingly driven by the economies of scale and research funding, we propose an alternative online open and connected framework (OOC) for building global learning communities using mobile social media. We critique a three year action research case study involving building collaborative global learning…

  3. Building with shapes

    CERN Document Server

    Mooney, Carla

    2014-01-01

    There are shapes everywhere you look. You can put shapes together or build with them. What can you build with three circles? In this title, students will explore and understand that certain attributes define what a shape is called. This title will allow students to identify the main purpose of a text, including what the author wants to answer, explain, or describe.

  4. Building information modelling (BIM)

    CSIR Research Space (South Africa)

    Conradie, Dirk CU

    2009-02-01

    Full Text Available The concept of a Building Information Model (BIM) also known as a Building Product Model (BPM) is nothing new. A short article on BIM will never cover the entire filed, because it is a particularly complex filed that is recently beginning to receive...

  5. LARGE BUILDING RADON MANUAL

    Science.gov (United States)

    The report summarizes information on how bilding systems -- especially the heating, ventilating, and air-conditioning (HVAC) system -- inclurence radon entry into large buildings and can be used to mitigate radon problems. It addresses the fundamentals of large building HVAC syst...

  6. High rise buildings

    Energy Technology Data Exchange (ETDEWEB)

    Horn, M.

    1980-06-01

    The feasibility of developing new energy conservation standards for high rise residential-type buildings including hotels, motels, apartment houses, and lodging houses is discussed. Differences between the high and low rise residential building energy regulations are summarized. The data collection method and results are presented. (MCW)

  7. ATLSS Integrated Building System

    OpenAIRE

    ECT Team, Purdue

    2007-01-01

    The AIBS (ATLSS Integrated Building Systems) program was developed to coordinate ongoing research projects in automated construction and connection systems. The objective of this technology is to design, fabricate, erect, and evaluate cost-effective building systems with a focus on providing a computer integrated approach to these activities.

  8. Validation study of the prototype of a disease-specific index measure for health-related quality of life in dementia

    Science.gov (United States)

    2012-01-01

    Background Index measures for health-related quality of life (HRQoL) quantify the desirability (utility) of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific index measures on the other hand combine disease-specificity and quantification of perceived quality on several health domains of a certain disease into one single figure. These instruments have been developed for several diseases, but a dementia-specific HRQoL index instrument was not yet available. Facing the increasing individual and societal burden of dementia, specific HRQoL values with metric characteristics are especially useful because they will provide vital information for health outcome research and economic evaluations. Aims of the study To develop and validate the prototype of a dementia-specific HRQoL index measure: Dementia Quality of life Instrument (DQI), as the first step towards valuation of the dementia health state. Methods For development of the DQI we created a conceptual framework based on a review of the literature, qualitative interviews with people with dementia and their carers, expert opinion and team discussion. To assess validity we undertook a survey under 241 dementia professionals. Measurements consisted of ranking (1–5) and rating (1–10) of 5 dementia-specific DQI domains (memory, orientation, independence, social activities and mood) and simultaneously rating of 9 DQI-derived health states on a visual analogue scale (VAS). We also performed a cross-sectional study in a large sample of people with very mild to moderate dementia and their caregivers (N = 145) to assess feasibility and concurrent validity. In addition, caregivers valued 10 DQI and 10 EQ-5D + C derived health states of the patient simultaneously on the same VAS. Setting: outpatient clinics, nursing homes and patient residences. Results All professionals judged the

  9. CERN's newest building

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    With a growing number of users looking for offices, the shortage of space has become acute, particularly for physicists. Building 42, inaugurated on Friday 11 February, offers almost 300 new work-spaces and a particularly pleasant working environment.   Mauro Dell’Ambrogio, the Swiss State Secretary for Education and Research (left), Rolf Heuer , CERN Director-General (centre), and Mark Muller, President of the Government of the Republic and Canton of Geneva and Head of the Department of Construction and Information Technology (right) at the opening of Building 42 on 11 February, 2011.   Construction work for the new Building 42 began in January 2009, thanks to support from the Swiss foundation FIPOI (Fondation des immeubles pour les organisations internationales). After two years of work, the building, an extension of Building 40, is ready to accommodate physicists from around the world who have come to work on the LHC. "We had more than 25 external contractors working...

  10. Technical Management for Buildings

    CERN Document Server

    Vairo, Antonio

    1999-01-01

    This paper is a presentation of an 'instrument' for the optimization of the functionality and conservation of tertiary buildings. This technique has several different names: Building Automation Systems (BAS), Central Control and Monitoring System (CCMS) in English, and Gestion Technique du Bâtiment' (GTB) or Gestion Technique Centralisée (GTC) in French. With this technique it is possible to manage all the functions of a building, it is a modern instrument that introduces the concept of 'automation' in the operation of buildings using computerized procedures, earlier reserved for industrial processes. The system is structured with different automation levels with a distributed intelligence, each level characterized by a communication system (Fieldbus for the lowest and Ethernet for the highest level). In order to apply the BAS to CERN buildings it is necessary to evaluate the advantages, the CERN requirements and the integration with the several existing control and automation systems.

  11. DGNB Building Certification Companion

    DEFF Research Database (Denmark)

    Møller, Renate Skovgaard; Rhodes, Michael K.; Larsen, Tine Steen

    2017-01-01

    In the construction industry, the popularity of sustainability and its benefits have been on the rise in recent years. Alas, with various building sustainability assessment schemes on the market, there is still no single general method for a comprehensive and inclusive design and building process...... for sustainable buildings. The literature describes several barriers of entry preventing actors in the industry from seeking sustainability certifications and prioritizing design methods, supporting sustainability in greater numbers. In the newly developed tool, “DGNB building certification companion: Sustainable...... Tool for Assessment, Planning, Learning, and Engaging (STAPLE)”, a new Excel-based, interactive, and iterative education focused platform is introduced, intended to engage dialog among stakeholders, building owners, and decision makers, and the assigned group team leaders, based on the five DGNB topics...

  12. Building the green way.

    Science.gov (United States)

    Lockwood, Charles

    2006-06-01

    Just five or six years ago, the term "green building" evoked visions of barefoot, tie-dyed, granola-munching denizens. There's been a large shift in perception. Of course, green buildings are still known for conserving natural resources by, for example, minimizing on-site grading, using alternative materials, and recycling construction waste. But people now see the financial advantages as well. Well-designed green buildings yield lower utility costs, greater employee productivity, less absenteeism, and stronger attraction and retention of workers than standard buildings do. Green materials, mechanical systems, and furnishings have become more widely available and considerably less expensive than they used to be-often cheaper than their standard counterparts. So building green is no longer a pricey experiment; just about any company can do it on a standard budget by following the ten rules outlined by the author. Reliable building-rating systems like the U.S. Green Building Council's rigorous Leadership in Energy and Environmental Design (LEED) program have done much to underscore the benefits of green construction. LEED evaluates buildings and awards points in several areas, such as water efficiency and indoor environmental quality. Other rating programs include the UK's BREEAM (Building Research Establishment's Environmental Assessment Method) and Australia's Green Star. Green construction is not simply getting more respect; it is rapidly becoming a necessity as corporations push it fully into the mainstream over the next five to ten years. In fact, the author says, the owners of standard buildings face massive obsolescence. To avoid this problem, they should carry out green renovations. Corporations no longer have an excuse for eschewing environmental and economic sustainability. They have at their disposal tools proven to lower overhead costs, improve productivity, and strengthen the bottom line.

  13. Energy management systems in buildings

    Energy Technology Data Exchange (ETDEWEB)

    Lush, D.M.

    1979-07-01

    An investigation is made of the range of possibilities available from three types of systems (automatic control devices, building envelope, and the occupants) in buildings. The following subjects are discussed: general (buildings, design and personnel); new buildings (envelope, designers, energy and load calculations, plant design, general design parameters); existing buildings (conservation measures, general energy management, air conditioned buildings, industrial buildings); man and motivation (general, energy management and documentation, maintenance, motivation); automatic energy management systems (thermostatic controls, optimized plant start up, air conditioned and industrial buildings, building automatic systems). (MCW)

  14. Building Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Heli Koukkari

    2010-07-01

    Full Text Available Although social, economic, and cultural indicators are of substantial importance to the concept of sustainable building, this concept is usually related to environmental characteristics. Any building level assessment method is complex and involves contradictory aspects. Moreover, emphasizing qualitative criteria only increases confusion. R&D and standardization are thus concentrated to transparency and usability of the environmental methods. Other directions of research aim at performance-based design and methods to take regional and cultural aspects into account. In this paper, the perspectives of the sustainability assessment of a whole building are presented, based on a state of the art, feasibility study on performance analysis and the development of an extended life-cycle assessment for buildings. Using various tools, and based on the case studies of building sustainability assessment, environmental indicators were often shown to be of lesser importance than the other, soft ones. The first steps in the development of a building sustainability assessment method for Portuguese residential buildings will be presented and discussed in the end.

  15. Building Software with Gradle

    CERN Multimedia

    CERN. Geneva; Studer, Etienne

    2014-01-01

    In this presentation, we will give an overview of the key concepts and main features of Gradle, the innovative build system that has become the de-facto standard in the enterprise. We will cover task declaration and task graph execution, incremental builds, multi-project builds, dependency management, applying plugins, extracting reusable build logic, bootstrapping a build, and using the Gradle daemon. By the end of this talk, you will have a good understanding of what makes Gradle so powerful yet easy to use. You will also understand why companies like Pivotal, LinkedIn, Google, and other giants with complex builds count on Gradle. About the speakers Etienne is leading the Tooling Team at Gradleware. He has been working as a developer, architect, project manager, and CTO over the past 15 years. He has spent most of his time building software products from the ground up and successfully shipping them to happy customers. He had ...

  16. Buildings Interoperability Landscape

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-12-31

    Through its Building Technologies Office (BTO), the United States Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE-EERE) is sponsoring an effort to advance interoperability for the integration of intelligent buildings equipment and automation systems, understanding the importance of integration frameworks and product ecosystems to this cause. This is important to BTO’s mission to enhance energy efficiency and save energy for economic and environmental purposes. For connected buildings ecosystems of products and services from various manufacturers to flourish, the ICT aspects of the equipment need to integrate and operate simply and reliably. Within the concepts of interoperability lie the specification, development, and certification of equipment with standards-based interfaces that connect and work. Beyond this, a healthy community of stakeholders that contribute to and use interoperability work products must be developed. On May 1, 2014, the DOE convened a technical meeting to take stock of the current state of interoperability of connected equipment and systems in buildings. Several insights from that meeting helped facilitate a draft description of the landscape of interoperability for connected buildings, which focuses mainly on small and medium commercial buildings. This document revises the February 2015 landscape document to address reviewer comments, incorporate important insights from the Buildings Interoperability Vision technical meeting, and capture thoughts from that meeting about the topics to be addressed in a buildings interoperability vision. In particular, greater attention is paid to the state of information modeling in buildings and the great potential for near-term benefits in this area from progress and community alignment.

  17. Building Social Web Applications

    CERN Document Server

    Bell, Gavin

    2009-01-01

    Building a web application that attracts and retains regular visitors is tricky enough, but creating a social application that encourages visitors to interact with one another requires careful planning. This book provides practical solutions to the tough questions you'll face when building an effective community site -- one that makes visitors feel like they've found a new home on the Web. If your company is ready to take part in the social web, this book will help you get started. Whether you're creating a new site from scratch or reworking an existing site, Building Social Web Applications

  18. Measurement in Sustainable Building

    DEFF Research Database (Denmark)

    Hale, Lara

    2018-01-01

    of facing the disparity between the measurement of quantities and the experience of quality, seeks to bridge the gap with thorough evaluation programs and engagement with market and sociological research. Whereas well-being is not technically measureable, these evaluations lead to improvement of the metrics......Measurement is a necessary aspect of planning and constructing buildings. However, recent attempts to integrate the social dimension of sustainable building into building design and specifications demand measurement of non-technical qualities, such as well-being. The Active House Alliance, in lieu...

  19. Mycotoxins in building materials

    DEFF Research Database (Denmark)

    Nielsen, Kristian Fog; Frisvad, Jens Christian

    2011-01-01

    as in future energy efficient buildings. It brings together different disciplinary points of view on indoor mold, ranging from physics and material science to microbiology and health sciences. The contents have been outlined according to three main issues: Fundamentals, particularly addressing the crucial...... for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures. This book aims to describe the fundamentals of indoor mold growth as a prerequisite to tackle mold growth in the existing building stock as well...

  20. Integrated Building Design

    DEFF Research Database (Denmark)

    Heiselberg, Per

    In the first half of the 20th century, HVAC systems and artificial lighting were developed to meet indoor comfort needs. Before the introduction of mechanical systems, climate - not building style or appearance - was the major determinant of building form. Comfort was achieved through passive means...... and architectural features built into the design. However, with the advent of new technologies, architects were no longer constrained by the need to ensure that buildings had ample daylighting, remained airy and cool in the summer and warm in the winter. Since HVAC systems and artificial lighting could satisfy...

  1. Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Bourrelle, Julien S.; Musall, Eike

    2010-01-01

    and identify possible renewable energy supply options which may be considered in calculations. Finally, the gap between the methodology proposed by each organisation and their respective national building code is assessed; providing an overview of the possible changes building codes will need to undergo......The international cooperation project IEA SHC Task 40 / ECBCS Annex 52 “Towards Net Zero Energy Solar Buildings”, attempts to develop a common understanding and to set up the basis for an international definition framework of Net Zero Energy Buildings (Net ZEBs). The understanding of such buildings...... parameters used in the calculations are discussed and the various renewable supply options considered in the methodologies are summarised graphically. Thus, the paper helps to understand different existing approaches to calculate energy balance in Net ZEBs, highlights the importance of variables selection...

  2. Building Blueprints: Coming Home.

    Science.gov (United States)

    Schmidt, Wayne S.

    1999-01-01

    Discusses how renovation helped the headquarters for Indiana University's Alumni Association extend an atmosphere of hospitality and engender alumni loyalty. Before and after photos are provided along with a description of the building design. (GR)

  3. VT College Campus Buildings

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) This datalayer is comprised of campus building site points which belong to various Vermont colleges and universities. Only institutions that offer...

  4. Municipal Building Energy Usage

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This data set contains energy use data from 2009-2014 for 139 municipally operated buildings. Metrics include: Site & Source EUI, annual electricity, natural...

  5. Building a Circular Future

    DEFF Research Database (Denmark)

    Merrild, Heidi; Guldager Jensen, Kasper; Sommer, John

    2016-01-01

    of the circular strategies is not only in the future. Increased flexibility, optimized operation and maintenance, as well as a healthier building, is low-hanging fruit that can be harvested today. The project’s principles can be implemented in industrialized construction in a large scale today. That is proven......Natural resources are scarce and construction accounts for 40 percent of the material and energy consumption in Europe. This means that a switch to a circular future is necessary. ’Building a Circular Future’ maps out where we are, where we are going, and what is needed for this conversion to take...... on the project’s strategies. The financial result is a profit of DKK 35 million on the structure alone in the demolition of a building built for the cost of DKK 860 million. The total potential for the whole building, calculated in projected material prices, is estimated to be up to 16% of the total construction...

  6. Flight Research Building (Hangar)

    Data.gov (United States)

    Federal Laboratory Consortium — The NASA Glenn Flight Research Building is located at the NASA Glenn Research Center with aircraft access to Cleveland Hopkins International Airport. The facility is...

  7. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, S.

    Whenever we shop, the products we consider buying are labelled with the economical price we have to pay if we want to purchase them - an important parameter in our decisions as purchasers. The increrasing awareness for environmental limits and backlashes of human activities also in the building...... sector have fostered the wish to define 'the ecological price' of a building as a help for environmental conscious decision-making. In a social constructivist approach this Ph.D. thesis looks across and beyond the manifold existing approaches for environmental indicators for buildings. It acknowledges...... in the Netherlands. It identifies lines of conflict and areas of consent betweeen the relevant actors and elaborates scenarios for a possible closure of ongoing debate about environmental indicators for buildings....

  8. Build your own superlattice

    NARCIS (Netherlands)

    Rijnders, Augustinus J.H.M.; Blank, David H.A.

    2005-01-01

    Artificial materials made from oxide building blocks turn out to be excellent ferroelectrics. This shows that materials with specific properties can be designed by atomic-scale tailoring of their composition.

  9. Building capacity in Benin

    International Development Research Centre (IDRC) Digital Library (Canada)

    sigp1. Building capacity in. Benin. Training of technical staff of municipalities in the Okpara Basin of Benin in the use of GIS tools for water management, hydrological modeling and soil conservation. Introduction. A training workshop was ...

  10. Buildings Sector Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.

    2005-08-01

    A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.

  11. Building perservation practice

    DEFF Research Database (Denmark)

    Pilegaard, Marie Kirstine

    of architects and planners is primarily to reconcile the conservation prospects with the future use of buildings and sites. They intermediary the site through selections of the narratives, and in practice the restoration or transformation projects becomes a communication of the selected story, utilized...... through education, such as documentation of buildings and the restoration as a way of communicating the architect's intervention on the building, meanwhile the communication of the buildings history is seen as a "natural" skill and the methods are not questioned in the practice. The storytelling has today......Cultural Heritage sites are in the current practice, defined as everything you find on a site within a delimited selected area. Written sources and guidelines for the preservation of the cultural heritage, written by the public authorities or professionals describe them as places that tell a story...

  12. Building Services Systems

    DEFF Research Database (Denmark)

    Zinzi, Michele; Romeo, Carlo; Thomsen, Kirsten Engelund

    2015-01-01

    This guideline on Building Services Systems is one of four guidelines produced by the School of the Future project. The other three guidelines cover: Building Construction Elements, Improved Indoor Environmental Quality and Concepts for Zero Emission Schools. This guideline consists of the descri......This guideline on Building Services Systems is one of four guidelines produced by the School of the Future project. The other three guidelines cover: Building Construction Elements, Improved Indoor Environmental Quality and Concepts for Zero Emission Schools. This guideline consists...... of the description of 5 main technologies: condensing boilers, heat pumps, ventilation systems, lighting and photovoltaic systems. For each technology chapter there is the same content list: an introduction, a brief technology description, some advantages and disadvantages, market penetration and utilisation, energy...

  13. Early Building Design

    DEFF Research Database (Denmark)

    Østergård, Torben; Jensen, Rasmus Lund; Maagaard, Steffen

    2017-01-01

    Highlights •Development of a design methodology that can handle the vast design space in early building design. •A global design space is modelled from extensive Monte Carlo simulations. •Sensitivity analysis methods applied to guide decision-makers. •Interactive visualizations help the multi......-actor design team explore thousands of building performance simulations. •Metamodels are used to run additional simulations and demonstrate the holistic consequences of input changes....

  14. Building Materials in Arctic Climate

    DEFF Research Database (Denmark)

    Jensen, Ole Mejlhede

    2005-01-01

    Building in the artic requires special attention on the appropriateness of building materials. The harsh climate makes execution difficult and sets unusual requirements for the pure material properties. In addition, there is a lack of choice of good, natural building materials in the arctic....... This results in high transport costs. The building materials situation in Greenland may potentially be improved by intensifying the reuse of building materials or by promoting the local production of building materials....

  15. Comparison of efficacy of the disease-specific LOX1- and constitutive cytomegalovirus-promoters in expressing interleukin 10 through adeno-associated virus 2/8 delivery in atherosclerotic mice.

    Directory of Open Access Journals (Sweden)

    Hongqing Zhu

    Full Text Available The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of "disease-specific promoters" has strong appeal. Many therapeutic genes, including transforming growth factor beta 1 or interleukin 10, are associated to adverse effects. The use of a disease-specific promoter might minimize toxicity. The lectin-like oxidized low density lipoprotein receptor 1 is a marker of cardiovascular disease and a potential therapeutic target. The lectin-like oxidized low density lipoprotein receptor 1 is known to be up-regulated early during disease onset in a number of cell types at the sites where the disease will be clinically evident. In this study an adeno-associated virus-2 DNA vector (AAV2 using the AAV8 capsid, and containing the full length The lectin-like oxidized low density lipoprotein receptor 1 promoter, was generated and assayed for its ability to express human interleukin 10 in low density lipoprotein receptor knockout mice on high cholesterol diet. The cytomegalovirus early promoter was used for comparison in a similarly structured vector. The two promoters were found to have equal efficacy in reducing atherogenesis as measured by aortic systolic blood velocity, aortic cross sectional area, and aortic wall thickness. This is the first head-to-head comparison of a constitutive with a disease-specific promoter in a therapeutic context. These data strongly suggest that the use of a disease-specific promoter is appropriate for therapeutic gene delivery.

  16. Mauritius green building handbook, vol 1: Building envelope

    CSIR Research Space (South Africa)

    Van Wyk, Llewellyn V

    2010-08-01

    Full Text Available The building envelope plays a significant role in the performance of a building, especially with regard to the green building components. This chapter will focus on the external building envelope only, i.e., sub-structure, super structure, and roof...

  17. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, S.

    Whenever we shop, the products we consider buying are labelled with the economical price we have to pay if we want to purchase them - an important parameter in our decisions as purchasers. The increrasing awareness for environmental limits and backlashes of human activities also in the building s...... in the Netherlands. It identifies lines of conflict and areas of consent betweeen the relevant actors and elaborates scenarios for a possible closure of ongoing debate about environmental indicators for buildings.......Whenever we shop, the products we consider buying are labelled with the economical price we have to pay if we want to purchase them - an important parameter in our decisions as purchasers. The increrasing awareness for environmental limits and backlashes of human activities also in the building...... sector have fostered the wish to define 'the ecological price' of a building as a help for environmental conscious decision-making. In a social constructivist approach this Ph.D. thesis looks across and beyond the manifold existing approaches for environmental indicators for buildings. It acknowledges...

  18. Buildings Energy Technology; (USA)

    Energy Technology Data Exchange (ETDEWEB)

    Cason, D.L.; Hicks, S.C. (eds.)

    1991-01-01

    Buildings Energy Technology (BET) announces on a monthly basis the current worldwide information available on the technology required for economic energy conservation in buildings and communities. Each issue of BET also will include an article presenting a program overview or highlighting a current energy conservation technology project of DOE's Office of Building Technologies (OBT) plus a listing of scheduled meetings of interest. This publication contains the abstracts of DOE reports, journal articles, conference papers, patents, theses, and monographs added to the Energy Science and Technology Database (EDB) during the past month. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through the International Energy Agency's Energy Technology Data Exchange or government-to-government agreements.

  19. Building membrane nanopores

    Science.gov (United States)

    Howorka, Stefan

    2017-07-01

    Membrane nanopores--hollow nanoscale barrels that puncture biological or synthetic membranes--have become powerful tools in chemical- and biosensing, and have achieved notable success in portable DNA sequencing. The pores can be self-assembled from a variety of materials, including proteins, peptides, synthetic organic compounds and, more recently, DNA. But which building material is best for which application, and what is the relationship between pore structure and function? In this Review, I critically compare the characteristics of the different building materials, and explore the influence of the building material on pore structure, dynamics and function. I also discuss the future challenges of developing nanopore technology, and consider what the next-generation of nanopore structures could be and where further practical applications might emerge.

  20. Zero Energy Building

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Heiselberg, Per; Bourrelle, J.S.

    2011-01-01

    , (4) the type of energy balance, (5) the accepted renewable energy supply options, (6) the connection to the energy infrastructure and (7) the requirements for the energy efficiency, the indoor climate and in case of gird connected ZEB for the building–grid interaction. This paper focuses......The concept of Zero Energy Building (ZEB) has gained wide international attention during last few years and is now seen as the future target for the design of buildings. However, before being fully implemented in the national building codes and international standards, the ZEB concept requires...... clear and consistent definition and a commonly agreed energy calculation methodology. The most important issues that should be given special attention before developing a new ZEB definition are: (1) the metric of the balance, (2) the balancing period, (3) the type of energy use included in the balance...

  1. Energy planning for buildings

    Energy Technology Data Exchange (ETDEWEB)

    Sizemore, M.M.; Clark, H.O.; Ostrander, W.S.

    1979-01-01

    A proven process that design professionals can use or adapt to study the present energy performance of a building, uncover opportunities for energy-conscious improvements, evaluate those opportunities, and see to it that they are carried out to the owner's best benefit is presented. The first chapter offers a study of the basic concerns of energy planning. Chapter 2 takes up the roles and responsibilities of the team needed to carry a project through to a successful end. Chapter 3 shows how to study a building's present performance while the next chapter pinpoints those opportunities. Chapter 6 shows what is needed to carry out the recommendations stemming from the evaluation and offers much advice to the energy planner and owner for monitoring the results and maintaining the renewed building at a peak of performance. A sample problem illustrates the procedural steps necessary for energy planning.

  2. Building brains for bodies

    Science.gov (United States)

    Brooks, Rodney Allen; Stein, Lynn Andrea

    1994-01-01

    We describe a project to capitalize on newly available levels of computational resources in order to understand human cognition. We will build an integrated physical system including vision, sound input and output, and dextrous manipulation, all controlled by a continuously operating large scale parallel MIMD computer. The resulting system will learn to 'think' by building on its bodily experiences to accomplish progressively more abstract tasks. Past experience suggests that in attempting to build such an integrated system we will have to fundamentally change the way artificial intelligence, cognitive science, linguistics, and philosophy think about the organization of intelligence. We expect to be able to better reconcile the theories that will be developed with current work in neuroscience.

  3. Building information deduced

    DEFF Research Database (Denmark)

    Tamke, Martin; Myrup Jensen, Morten; Beetz, Jakob

    2014-01-01

    In recent years, Building Information Models have become commonplace in building profession. The extensive use and increasing experience with BIM models offers new perspectives and potentials for design and planning. A recent stakeholder study conducted by the authors of this paper show...... of a model, differences in separate models or models from different point of time. Current BIM tools support both modes only in a rudimentary form. This paper discusses current modes of information query within and across BIM models, shows beneficial scenarios for building and planning practice through...... that in practice models are no longer solely observed as culmination of knowledge in a 3d representation of future built structures, but as a source of information in itself. Experienced users of BIM want to Find Information within a model or across a set of these and Compare models in order to evaluate states...

  4. Buildings for advanced technology

    CERN Document Server

    Teague, E; Murday, James

    2015-01-01

    This book deals with the design and construction of buildings for nanoscale science and engineering research. The information provided in this book is useful for designing and constructing buildings for such advanced technologies as nanotechnology, nanoelectronics and biotechnology. The book outlines the technology challenges unique to each of the building environmental challenges outlined below and provides best practices and examples of engineering approaches to address them: • Establishing and maintaining critical environments: temperature, humidity, and pressure • Structural vibration isolation • Airborne vibration isolation (acoustic noise) • Isolation of mechanical equipment-generated vibration/acoustic noise • Cost-effective power conditioning • Grounding facilities for low electrical interference • Electromagnetic interference (EMI)/Radio frequency interference (RFI) isolation • Airborne particulate contamination • Airborne organic and chemical contamination • Environment, safety a...

  5. Trends in Public Library Buildings.

    Science.gov (United States)

    Holt, Raymond M.

    1987-01-01

    Review of trends in public library buildings covers cycles in building activity; financial support; site selection; expansion, remodeling, or conversion of existing buildings; size of buildings; and such architectural concerns as flexible space, lighting, power, accommodation of computer systems, heat and ventilation, fire protection, security,…

  6. SOLAR EFFECTS ON BUILDING DESIGN.

    Science.gov (United States)

    Building Research Inst., Inc., Washington, DC.

    A REPORT OF A PROGRAM HELD AS PART OF THE BUILDING RESEARCH INSTITUTE 1962 SPRING CONFERENCE ON THE SOLAR EFFECTS ON BUILDING DESIGN. TOPICS DISCUSSED ARE--(1) SOLAR ENERGY DATA APPLICABLE TO BUILDING DESIGN, (2) THERMAL EFFECTS OF SOLAR RADIATION ON MAN, (3) SOLAR EFFECTS ON ARCHITECTURE, (4) SOLAR EFFECTS ON BUILDING COSTS, (5) SELECTION OF…

  7. Carbon Efficient Building Solutions

    Directory of Open Access Journals (Sweden)

    Pellervo Matilainen

    2010-03-01

    Full Text Available Traditionally, the Finnish legislation have focused on energy use and especially on energy used for heating space in buildings. However, in many cases this does not lead to the optimal concept in respect to minimizing green house gases. This paper studies how CO2 emission levels are affected by different measures to reduce energy use in buildings. This paper presents two real apartment buildings with different options of energy efficiency and power sources. The calculations clearly show that in the future electricity and domestic hot water use will have high importance in respect to energy efficiency, and therefore also CO2 equivalent (eq emissions. The importance increases when the energy efficiency of the building increases. There are big differences between average Finnish production and individual power plants; CO2 eq emissions might nearly double depending on the energy source and the power plant type. Both a building with an efficient district heating as a power source, and a building with ground heat in addition to nuclear power electricity as a complimentary electricity source performed very similarly to each other in respect to CO2 eq emissions. However, it is dangerous to conclude that it is not important which energy source is chosen. If hypothetically, the use of district heating would dramatically drop, the primary energy factor and CO2 eq emissions from electricity would rise, which in turn would lead to the increase of the ground heat systems emissions. A problem in the yearly calculations is that the fact that it is very important, sometimes even crucial, when energy is needed, is always excluded.

  8. Building the perfect PC

    CERN Document Server

    Thompson, Robert Bruce

    2006-01-01

    This popular Build-It-Yourself (BIY) PC book covers everything you want to know about building your own system: Planning and picking out the right components, step-by-step instructions for assembling your perfect PC, and an insightful discussion of why you'd want to do it in the first place. Most big brand computers from HP, Dell and others use lower-quality components so they can meet their aggressive pricing targets. But component manufacturers also make high-quality parts that you can either purchase directly, or obtain through distributors and resellers. Consumers and corporations

  9. Ecology Beyond Building

    DEFF Research Database (Denmark)

    Peters, Terri

    2011-01-01

    As the designers of the WWf building in Zeist, The Netherslands a CO2-neutral, self-sufficient office complex, RAU has set the bar for sustainable research and design. Guesteditor Terri Peters visited the firm's studio in Amsterdam to talk to principal Thomas Rau. As Peters relates, Rau prefers t...... to put on the dwindling supply of raw materials rather than the immidiate problems of energy consumption for which there are solutions within reach. With the emphasis on a more far-reaching approach, he places buildings in a wider context of ecological thinking and systems....

  10. LHCb Dockerized Build Environment

    Science.gov (United States)

    Clemencic, M.; Belin, M.; Closier, J.; Couturier, B.

    2017-10-01

    Used as lightweight virtual machines or as enhanced chroot environments, Linux containers, and in particular the Docker abstraction over them, are more and more popular in the virtualization communities. The LHCb Core Software team decided to investigate how to use Docker containers to provide stable and reliable build environments for the different supported platforms, including the obsolete ones which cannot be installed on modern hardware, to be used in integration builds, releases and by any developer. We present here the techniques and procedures set up to define and maintain the Docker images and how these images can be used to develop on modern Linux distributions for platforms otherwise not accessible.

  11. Building UIs with Wijmo

    CERN Document Server

    Zhang, Yuguang

    2013-01-01

    Written with an example-based approach, Building UIs with Wijmo leads you step by step through the implementation and customization of each library component and its associated resources. Reference tables of each configuration option, method, and event for each component are provided, alongside detailed explanations of how each widget is used.Building UIs with Wijmo is targeted at readers who are familiar with HTML, CSS, JavaScript, and jQuery, and have a basic understanding of web development. Although knowledge of jQuery UI is not mandatory, it would be a bonus as it is quite similar to Wijm

  12. Quantifying drug-protein binding in vivo.

    Energy Technology Data Exchange (ETDEWEB)

    Buchholz, B; Bench, G; Keating III, G; Palmblad, M; Vogel, J; Grant, P G; Hillegonds, D

    2004-02-17

    Accelerator mass spectrometry (AMS) provides precise quantitation of isotope labeled compounds that are bound to biological macromolecules such as DNA or proteins. The sensitivity is high enough to allow for sub-pharmacological (''micro-'') dosing to determine macromolecular targets without inducing toxicities or altering the system under study, whether it is healthy or diseased. We demonstrated an application of AMS in quantifying the physiologic effects of one dosed chemical compound upon the binding level of another compound in vivo at sub-toxic doses [4].We are using tissues left from this study to develop protocols for quantifying specific binding to isolated and identified proteins. We also developed a new technique to quantify nanogram to milligram amounts of isolated protein at precisions that are comparable to those for quantifying the bound compound by AMS.

  13. Future Green Buildings

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Drysdale, David; Lund, Henrik

    an energy system integration perspective, heat savings, electricity savings, and user behavioural aspects as well as energy storage and household level flexibility. Many reports on green or sustainable buildings focus only on savings levels and disregard the cost of renewable energy production. Some reports...

  14. Experimental Building Information Models

    Science.gov (United States)

    2011-09-01

    facilitate interoperability between different software platforms covering the many disciplines that contribute to a building throughout its lifecycle . As...Library M_Ball Valve - 50-150 mm.rfa MEP Library M_Bath Tub.rfa MEP Library M_Cleanout Two-Way - PVC - Sch 40 - DWV.rfa MEP Library M_Drinking

  15. Building a Straw Bridge

    Science.gov (United States)

    Teaching Science, 2015

    2015-01-01

    This project is for a team of students (groups of two or three are ideal) to design and construct a model of a single-span bridge, using plastic drinking straws as the building material. All steps of the design, construction, testing and critiquing stages should be recorded by students in a journal. Students may like to include labelled diagrams,…

  16. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, S.

    Whenever we shop, the products we consider buying are labelled with the economical price we have to pay if we want to purchase them - an important parameter in our decisions as purchasers. The increrasing awareness for environmental limits and backlashes of human activities also in the building...

  17. Building Internet Search Engines

    Directory of Open Access Journals (Sweden)

    Mustafa Akgül

    1996-09-01

    Full Text Available Internet search engines are powerful tools to find electronics objects such as addresses of individuals and institutions, documents, statistics of all kinds, dictionaries, cata­logs, product information etc. This paper explains how to build and run some very common search engines on Unix platforms, so as to serve documents through the Web.

  18. Building Background Knowledge

    Science.gov (United States)

    Neuman, Susan B.; Kaefer, Tanya; Pinkham, Ashley

    2014-01-01

    This article make a case for the importance of background knowledge in children's comprehension. It suggests that differences in background knowledge may account for differences in understanding text for low- and middle-income children. It then describes strategies for building background knowledge in the age of common core standards.

  19. Vedr.: Military capacity building

    DEFF Research Database (Denmark)

    Larsen, Josefine Kühnel; Struwe, Lars Bangert

    2013-01-01

    Kühnel Larsen and researcher Lars Bangert Struwe of CMS had organized a seminar in collaboration with Royal Danish Defense Colleg and the East African Security Governance Network. The seminar focused on some of the risks involved in Military capacity building and how these risks are dealt with from...

  20. Buildings behaving badly

    NARCIS (Netherlands)

    Student, Jillian; Papyrakis, Elissaios; Beukering, van Pieter

    2017-01-01

    Heating buildings contributes to approximately 36 % of Europe’s energy demand and several EU member states have adopted mandatory energy labels to improve energy efficiency by promoting home weatherization investments. This paper focuses on the perception of the energy label for residential

  1. Energy efficient building design

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    The fundamental concepts of the building design process, energy codes and standards, and energy budgets are introduced. These tools were combined into Energy Design Guidelines and design contract requirements. The Guidelines were repackaged for a national audience and a videotape for selling the concept to government executives. An effort to test transfer of the Guidelines to outside agencies is described.

  2. Building Social Networks.

    Science.gov (United States)

    Giuffre, Katherine; Paxton, Pamela

    1997-01-01

    Proposes an exercise that allows students to build a physical network of ties and then to experience how it can influence individual opportunities. Provides an example exercise that applies this method to learning about inequality in job opportunities. Suggests other topics that can be illustrated using the same methods. (DSK)

  3. Customer loyalty building

    OpenAIRE

    Nováková, Veronika

    2012-01-01

    This bachelor thesis focuses on the customer loyalty. It gives an example of CRM project which aims to build the loyalty of customers to some brand or product so the customer would return to the company and would be satisfied with all products and services he get.

  4. Building Trust in Organic

    OpenAIRE

    Huber, Beate

    2007-01-01

    What are the basics for setting up an organic certification body? How is an efficient and service-oriented certification system implemented? How should the necessary documentation be developed? These are some questions that are explained thoroughly in the completely revised IFOAM publication "Building Trust in Organic".

  5. Gaze Interactive Building Instructions

    DEFF Research Database (Denmark)

    Hansen, John Paulin; Ahmed, Zaheer; Mardanbeigi, Diako

    We combine eye tracking technology and mobile tablets to support hands-free interaction with digital building instructions. As a proof-of-concept we have developed a small interactive 3D environment where one can interact with digital blocks by gaze, keystroke and head gestures. Blocks may be moved...

  6. Moisture conditions in buildings

    DEFF Research Database (Denmark)

    Rode, Carsten

    2012-01-01

    Growth of mould requires the presence of moisture at a certain high level. In a heated indoor environment such moisture levels occur only if there is a reason for the moisture supply. Such moisture can come from the use of the building, because of malfunctioning constructions, or it can...

  7. Checklist for Physics Buildings.

    Science.gov (United States)

    American Inst. of Physics, New York, NY.

    This booklet was written to encourage close communication between architect and client and to assist planners of physics facilities in providing important features of building design. Some 300 items considered important are listed Also included is a list of 17 references related to facility construction (many available free of charge. A companion…

  8. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis......, creating an essential basis for future indicator development....

  9. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    2004-01-01

    Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis......, creating an essential basis for future indicator development....

  10. Building with Sand

    Science.gov (United States)

    Ashbrook, Peggy

    2010-01-01

    Children playing in damp sand invariably try to make a tower or a tunnel. By providing experiences with a variety of materials, alone and together, teachers set up the conditions for children to learn through their senses and ensure that a class approaches a topic with a common set of experiences to build on. Learning about the properties of…

  11. Development of two Danish building typologies for residential buildings

    DEFF Research Database (Denmark)

    Kragh, Jesper; Wittchen, Kim Bjarne

    2014-01-01

    The aim of this paper is to present two Danish typologies for residential buildings developed in the EU-financed project TABULA. The building typologies focus on energy performance and can be used in the analyses of, e.g., political strategies for planning the future upgrading of the energy...... building types: single-family houses, terraced houses and blocks of flats. Each main building type is presented for nine periods representing age, typical building tradition and insulation levels. Finally, an energy balance model of the residential building stock was devised to validate the average...

  12. Irregular Shaped Building Design Optimization with Building Information Modelling

    OpenAIRE

    Lee, Xia Sheng; Yan, Chung Pui; See, Zi Siang

    2016-01-01

    This research is to recognise the function of Building Information Modelling (BIM) in design optimization for irregular shaped buildings. The study focuses on a conceptual irregular shaped “twisted” building design similar to some existing sculpture-like architectures. Form and function are the two most important aspects of new buildings, which are becoming more sophisticated as parts of equally sophisticated “systems” that we are living in. Nowadays, it is common to have irregular shaped or ...

  13. Building and using binoscopes

    CERN Document Server

    Butler, Norman

    2015-01-01

    Focusing on both homemade and commercial products, this book provides the reader with simple and straightforward information about the modelling and building of binoscopes. Binoscopes can be thought of as binoculars enlarged to the size of telescopes: essentially, a combination of the two. Constructing a binoscope is easier than most people think, but it still demands attention to detail and proper background knowledge. The author goes on to provide additional information about how to understand the products currently on the market, should the reader choose to purchase a binoscope instead of building one. Lastly, the book also compares binoscopes with telescopes in great detail, outlining the differences the reader can expect to see in the night sky from using both. The celestial views obtained with a binoscope, compared to a single telescope of the same aperture, are a very different experience and well worth the effort.

  14. Can we build inclusion?

    DEFF Research Database (Denmark)

    Kirkeby, Inge Mette; Grangaard, Sidse

    2016-01-01

    of some children with special needs. Hence the title – can we build inclusion? In the literature of Universal Design, accommodation and design features seldom reflect the less visible disabilities. The paper is based on a research project initiated to investigate how more or less space influences daily......Inclusion of children with special needs in kindergartens and preschools may be approached from different angles. This paper raises the question of whether the physical framework of kindergartens makes any difference for daily life at the kindergarten at all, and whether it can support inclusion...... on the answers in the interviews, we found support for answering the question in the title in the affirmative; we can build inclusion! This is because the teachers' experience indicated that, if there was sufficient space per child, there were fewer conflicts and the children managed to stay in the same activity...

  15. Agent Building Software

    Science.gov (United States)

    2000-01-01

    AgentBuilder is a software component developed under an SBIR contract between Reticular Systems, Inc., and Goddard Space Flight Center. AgentBuilder allows software developers without experience in intelligent agent technologies to easily build software applications using intelligent agents. Agents are components of software that will perform tasks automatically, with no intervention or command from a user. AgentBuilder reduces the time and cost of developing agent systems and provides a simple mechanism for implementing high-performance agent systems.

  16. Sick-building syndrome.

    Science.gov (United States)

    Stolwijk, J A

    1991-01-01

    The sick-building syndrome (SBS) is defined as the occurrence of an excessive number of subjective complaints by the occupants of a building. These complaints include headache, irritation of the eyes, nose, and throat, lethargy, inability to concentrate, objectionable odors, and less frequently, nausea, dizziness, chest tightness, etc. These complaints will always be reported by a fraction of the occupants of any building if a questionnaire is administered that asks the respondent to recall any subjective symptoms they remember having had in the last 2 weeks or or over some period of time. It is often considered that SBS symptom reports have a minimum prevalence of about 15 to 20% for a 2-week recall period. SBS symptoms reported by 30% or more of occupants are indicative of conditions in the building environment that warrant attention. It is not often that a clear, single cause is responsible for the excess symptom reports. The following factors, often in combinations, are seen to contribute to SBS: outdoor air supply that is inadequate, ventilation distribution or effectiveness that is inadequate, the presence of temporary or long-term sources of contaminants such as tobacco smoke, adhesives, composite materials such as chipboard, and the growth of microorganisms in the HVAC equipment or in carpets or other furnishings. Depending on which causes contribute, the condition may be intermittent or even temporary. Psychosocial factors such as labor-management relations and satisfaction or dissatisfaction with other factors in the work environment can have a profound influence on the level of response of the occupants to their environment. Although hard data are difficult to collect, it is likely that productivity in the office environment is sensitive to conditions causing SBS. PMID:1821387

  17. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience, IT Department

  18. Building a professional portfolio.

    OpenAIRE

    Arhippainen, Mikko

    2016-01-01

    Building a professional portfolio is a thesis report with buiding a professional portfolio for the author with a background in graphic design and event management with main interest on aesthetics side. This report describes the main process of selecting materials, planning and actually producing the portfolio. In addition to the portfolio there is a chapter with inspection on LinkedIn and other social medias when planning for jobsearch. Altogether it is many channels and a combination of ...

  19. [Sick building syndrome].

    Science.gov (United States)

    Epstein, Yoram

    2008-07-01

    Over the past 50 years, a new man-made ecosystem has developed--the controlled indoor environment within the sealed exterior shells of modern non-industrial buildings. Emitted toxic volatile compounds from building materials, furnishings, and equipment, and inappropriate ventilation (resulting from the need to reduce expenses) contribute to reduce indoor air quality (IAQ), which has considerable potential to affect public health. Consequently, health problems related to this ecosystem have emerged. "Building-related illnesses" (BRI) refers to a group of illnesses with a fairly homogeneous clinical picture, objective abnormalities on clinical or laboratory evaluation, and one or more identifiable sources or agents known to cause infectious, immunologic, or allergic diseases. The term "sick building syndrome" (SBS) is used to refer to a heterogeneous group of work-related symptoms--including irritation of the skin and mucous membranes of the eyes, nose, and throat, headache, fatigue, and difficulty concentrating. These are considered illnesses because of the occurrence of symptoms, even though affected workers do not have objective clinical or laboratory abnormalities and causative agents cannot be found. The clinical symptoms of SBS, although not life-threatening are disruptive: they reduce productivity and increase absenteeism from work. Noteworthy, the association of symptoms with psychosocial factors does not mean that "the problem is all in the workers' heads". The results of psychological testing of symptomatic and asymptomatic office workers are similar. To improve IAQ and reduce symptoms of SBS adequate ventilation and fresh air, which will reduce volatile compounds, maintaining thermal comfort (with humidity not exceeding 60%), and adequate lighting should be ensured.

  20. Capacity building in Nepal*

    OpenAIRE

    Dawe, Russell; Stobbe, Karl; Pokharel, Yagya Raj; Shrestha, Shrijana

    2016-01-01

    Healthcare providers from high-income countries often want to help underserved populations, but providing clinical care is not always a sustainable approach. Patan Academy of Health Sciences (PAHS), in Nepal, has taken an innovative approach to capacity building in healthcare. PAHS has partnered with rural family doctors from Canada to provide clinical bedside teaching to medical students in PAHS’s rural program, thereby making a sustainable contribution to healthcare in Nepal.

  1. Capacity building in Nepal

    Directory of Open Access Journals (Sweden)

    Russell Eric Dawe

    2016-12-01

    Full Text Available Healthcare providers from high-income countries often want to help underserved populations, but providing clinical care is not always a sustainable approach. Patan Academy of Health Sciences (PAHS, in Nepal, has taken an innovative approach to capacity building in healthcare. PAHS has partnered with rural family doctors from Canada to provide clinical bedside teaching to medical students in PAHS’s rural program, thereby making a sustainable contribution to healthcare in Nepal.

  2. Building Company Loyalty System

    OpenAIRE

    Haniková, Alžběta

    2010-01-01

    The thesis discusses the importance of loyal customers, and loyalty system as a tool for building loyalty. It defines loyalty and customer satisfaction, it deals with the issue of customer retention. It describes the history and types of loyalty programs, important factors for deciding on their implementation and problems associated with them. The practical part is concerned with the clothing market, Orsay company and its Orsay Club loyalty systeme. The work also includes a survey of the loya...

  3. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period, access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience. IT Department

  4. Building Brands Together

    DEFF Research Database (Denmark)

    Ind, Nicholas; Iglesias, Oriol; Schultz, Majken

    2013-01-01

    Co-creation is a rapidly emerging area of research. However, there is a lack of understanding as to how organizations use co-creation to build relationships and generate value. How does participation emerge and what outcomes does it deliver? To generate insight into the co-creation process, we cr...... the research shows that managers have to see participants as integral to the brand....

  5. BUILD UP Skills Danmark

    DEFF Research Database (Denmark)

    Forsingdal, Charlotte Vartou; Lauridsen, Vagn Holk; Hougaard, Karsten Frøhlich

    opfyldelsen af 2020-målene, skal de rette kompetencer inden for energief-fektivitet og brug af vedvarende energi være til stede blandt de udførende i bygge- og an-lægsbranchen. Det er på denne baggrund, at Europa-Kommissionen har igangsat Build Up Skills projektet på tværs af Europa. Formålet med denne...

  6. Innovation in Building Design

    Science.gov (United States)

    1983-01-01

    Thomas & Betts Corporation's Flat Conductor Cables, or FCC, were developed of necessity as aircraft and spacecraft became increasingly complex. In order to reduce size and weight of components, the use of thin flat wire instead of relatively thick and protrusive round cable, provided a dramatic reduction of the space occupied by the many miles of power distribution lines in an aerospace vehicle. Commercially, FCC offers cost savings in simplified building construction, reduced installation time and ease of alteration.

  7. Building the Knowledge Economy

    OpenAIRE

    Čerić, Vlatko

    2001-01-01

    Generation and exploitation of knowledge became one of the most significant components in the new economy. This paper first investigates influence of information and communications technology on economy, with specific emphasis on Internet economy and electronic commerce. The paper then describes characteristics of the knowledge economy, discusses knowledge, presents main issues relevant for building of knowledge economy and gives an overview of the situation and perspectives of knowledge econ...

  8. Rapid Building Assessment Project

    Science.gov (United States)

    2014-05-01

    data gathering. The second driver to be considered is data security & privacy . Should the DoD require the hosting of FirstFuel’s servers behind a DoD...201262 Building Energy Asset Management (BEAM) 159 April, 2014 Limitation Three: Beam Executable, which using Matlab compiler runtime and BCVTB... differentiated by the connection types between BAS and BEAM Runtime software. For operation in the “Stand Alone” mode, the software doesn’t need to be

  9. Building retrofit for cities

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, H.

    1979-11-01

    The impact of high fuel prices on retrofit in the urban sector is discussed. Then, the benefits of a strong urban retrofit program are enumerated. Institutional, financial, informational, and attitudinal barriers that stand in the way of widespread implementation of energy conservation retrofit are discussed. Policy tools which can be used to implement a retrofit program consist of tax breaks, financing arrangements, mandatory building efficiency standards, and education programs.

  10. Building doctoral ecologies

    DEFF Research Database (Denmark)

    Bengtsen, Søren Smedegaard

    2018-01-01

    During the recent years doctoral education has ultimately left its seclusion within the disciplines and become part of national and global policy agendas, claimed to ensure societal welfare and financial growth. As a consequence more resources have been allocated to the formalization and professi......, and discusses how institutions and doctoral programmes could use such sprawling spaces for learning to build doctoral ecologies and to strengthening existentially based pedagogies within doctoral education....

  11. Body Build Satisfaction and the Congruency of Body Build Perceptions.

    Science.gov (United States)

    Hankins, Norman E.; Bailey, Roger C.

    1979-01-01

    Females were administered the somatotype rating scale. Satisfied subjects showed greater congruency between their own and wished-for body build, and greater congruency between their own and friend/date body builds, but less congruency between their own body build and the female stereotype. (Author/BEF)

  12. Oakmead solar buildings

    Science.gov (United States)

    1981-03-01

    Twin 50,000 square feet industrial buildings, incorporating both active and passive solar design features, in the Oakmead Industrial Park, Santa Clara, California, employ slab floor construction and tilt-up concrete walls. A structural facia on the north extreme of each building provides a 45 deg support for approximately 2900 square feet of high-performance flat plate collectors. These liquid-based collectors form the basis for an active solar subsystem which includes a unique control logic to manage energy in a Second Law sense. The south-facing, vertical tilt-up concrete wall has been modified to accommodate some 1200 square feet of air-based collector fashioned after a Trombe design. The tilt-up wall fabrication technique is commonly used in commercial and industrial building construction, and shows promise for ready adaptation to passive solar heating applications. The combined active and passive subsystems were designed to provide approximately 90% of the annual energy requirements for heating and hot water.

  13. Allegheny County Building Footprint Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains photogrammetrically compiled roof outlines of buildings. All near orthogonal corners are square. Buildings that are less than 400 square feet...

  14. Upcoming renovations in Building 63

    CERN Multimedia

    2014-01-01

    La Poste will close its doors in Building 63 on Friday, 28 November. It moves to Building 510 and where it will open on 1 December (see picture).   UNIQA will close its HelpDesk in Building 63 on Wednesday, 26 November and will re-open the next day in Building 510. La Poste and UNIQA are expected to return to their renovated office space between April and May 2015.

  15. Intelligent buildings: removing the mystique

    Energy Technology Data Exchange (ETDEWEB)

    Kowaleski, M.J.

    1986-03-01

    The fundamentals of intelligent building design are discussed. System integration, reliability functionality, flexibility, and cost are the factors which are seen to underlie the design of systems and hardware configuration in such buildings. The problems associated with interfacing equipment from different manufacturers are discussed. It is concluded that building intelligence is simply another area of design which must be evaluated along with other building requirements.

  16. Hawaii-Okinawa Building Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, I.; Salasovich, J.

    2013-05-01

    NREL conducted energy evaluations at the Itoman City Hall building in Itoman, Okinawa Prefecture, Japan, and the Hawaii State Capitol building in Honolulu, Hawaii. This report summarizes the findings from the evaluations, including the best practices identified at each site and opportunities for improving energy efficiency and renewable energy. The findings from this evaluation are intended to inform energy efficient building design, energy efficiency technology, and management protocols for buildings in subtropical climates.

  17. Energy Flexibility in Retail Buildings

    DEFF Research Database (Denmark)

    Ma, Zheng; Billanes, Joy Dalmacio; Kjærgaard, Mikkel Baun

    2017-01-01

    Retail buildings has an important role for demand side energy flexibility because of their high energy consumption, variety of energy flexibility resources, and centralized control via building control systems. Energy flexibility requires agreements and collaborations among different actors......, barriers, and benefits), energy management activities and technology adoptions, and the stakeholders’ interaction for the energy flexibility in retail buildings....

  18. Classification of Building Object Types

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn

    2011-01-01

    be managed by software applications and on the basis of building models. Classification systems with taxonomies of building object types have many application opportunities but can still be beneficial in data exchange between building construction partners. However, this will be performed by new methods...... and in strong connection with databases holding a wide range of object types....

  19. Optimum Insulation of Building Envelopes

    DEFF Research Database (Denmark)

    Svendsen, Sv Aa Højgaard

    1997-01-01

    The problem of optimising building envelopes with respect to the overall aim of stimulating a sustainable development is described.A proposal is given for performing an optmization based on the priciple of making the same effort of saving energy in the building as supplying the building with ener...

  20. Team Building through Physical Challenges.

    Science.gov (United States)

    Gibbons, Sandra L.

    The enhancement of positive self-concept has been identified as a key benefit of participation in team-building programs. This paper reviews research on the impact of team-building activities that include demanding physical challenges on the self-concept of physical education students. Team Building through Physical Challenges (TBPC) is a program…

  1. Building thermography and energy performance directive of buildings

    Science.gov (United States)

    Kauppinen, Timo; Siikanen, Sami

    2012-06-01

    Energy Performance of Buildings Directive came in to the force in Europe couple of years ago and it had an immediate effect on Building Codes in Europe. Finland have changed its building codes since 2007 - the insulation requirements have been tightened and the requirements have been specified. The biggest change is energy efficient calculations and determination of energy efficiency and energy label for buildings. This has caused a boom of new service providers (thermography services, air-tightness measurements and other services like new calculation tools). Thermography is used in verification in performance of buildings. In this presentation some examples of building thermography in walk-through energy audits combined with the results of energy efficiency calculations are presented - also some special problems in buildings of specific use (e.g. an art museum) and use of thermography to solve them.

  2. Building Construction Elements, Building Envelope and Method for Constructing a Building Envelope

    DEFF Research Database (Denmark)

    2009-01-01

    High-strength concrete building system and method of assembly for construction a buiding envelope.......High-strength concrete building system and method of assembly for construction a buiding envelope....

  3. Building Envelope for New Buildings and Energy Renovation of Old Buildings

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian

    1997-01-01

    The Building Envelope Project at Technical University of Denmark should, in coorporation with associated trade organizations, strengthen the development on the building envelope area with focus on heat, moisture and economy...

  4. ECONOMY "SMART BUILDINGS" HOUSING

    Directory of Open Access Journals (Sweden)

    Stanka Djurić

    2017-01-01

    Full Text Available In terms of ensuring national security and the security of energy supply and energy sources, such as liquid fuels and gas, as well as energy independence from energy imports and energy, the focus of our strategy to shift towards renewable energy sources. In fact, whether a state of more or less energy-independent, to a large extent can be determined by the percentage participation renewable energy in meeting the total energy requirements. So, the consumption of renewable energy source (solar energy, wind energy, geothermal energy, hydropower and small watercourses, biomass and biogas is put in relation with the amount of power and energy which are imported from foreign countries (liquid fuels and gas. Based on data published by the European statistics agency, in developed European countries is the fact that renewable energy sources accounted for 10-12% of the total energy balance of individual countries. Here, the situation is very worrying, given that renewable energy resources still account for only 1% in the energy balance, which is negligible and intolerable little. On the other hand, environmental awareness that is constantly improving and developing required to behave and act in accordance with the capabilities and resources of nature and the natural environment. As the largest building and construction consume energy and also the biggest polluters of the environment, point to the request to change the method of construction and thus to change the way of life on the planet. Poor and inadequate access to the building and construction industry certainly is recognized as the most important factor in global warming. The progress of civilization, especially in terms of technical and technological innovation brings the design and construction of facilities that will be compatible with the environment. For designers and investors is to develop, design and build "green".

  5. Buildings Energy Technology

    Energy Technology Data Exchange (ETDEWEB)

    Cason, D.L.; Emmanuel, L. [eds.

    1996-11-01

    BET announces on a monthly basis current worldwide information available on the technology required for economic energy conservation in buildings and communities. It contains abstracts of DOE reports, journal articles, conference papers,patents,theses, and monographs added to the Energy Science and Technology Database during the past month. Also included are US information obtained through acquisition programs or interagency agreements and international information obtained through IEA`s Energy Technology Data Exchange or government- to-government agreements. The citations are available for online searching and retrieval; current information, added daily, is available to DOE and its contractors.

  6. Building Regional Competencies

    DEFF Research Database (Denmark)

    Norus, Jesper

    2004-01-01

    thereby formed the basis for globalization of the knowledge and the markets forindustrial enzymes. Last but not least the paper demonstrates how the region's majorfirm, Novozymes, the world-leading manufacturer of industrial enzymes, even beforethe term virtual organization came into fashion, positioned...... a dominating position in the global marketfor industrial enzymes from 1870-2004. The case of industrial enzymes shows how aregion has been able to build sustainable competitive advantages from its distinctivecompetencies. This is done through a mixture of outsourcing and in sourcing ofcompetencies, knowledge...

  7. Building Project Competence

    DEFF Research Database (Denmark)

    Pemsel, Sofia; Wiewiora, Anna

    This research investigates the development of project competence, and particularly, three related dynamic capabilities (shifting, adapting, leveraging) that contribute to project competence development. In doing so, we make use of the emerging literature on knowledge governance and theorize how...... knowledge governance mechanisms can move the organization towards desired knowledge-based goals. A multiple-case study comprising 23 cases advances our understanding of the elements that trigger, enable, hamper, and drive shifting, leveraging and adapting. Finally, the paper offers a tentative framework...... of dynamic capability building promoting project competence development....

  8. Building Web Reputation Systems

    CERN Document Server

    Farmer, Randy

    2010-01-01

    What do Amazon's product reviews, eBay's feedback score system, Slashdot's Karma System, and Xbox Live's Achievements have in common? They're all examples of successful reputation systems that enable consumer websites to manage and present user contributions most effectively. This book shows you how to design and develop reputation systems for your own sites or web applications, written by experts who have designed web communities for Yahoo! and other prominent sites. Building Web Reputation Systems helps you ask the hard questions about these underlying mechanisms, and why they're critical

  9. Building Transdisciplinary Environmental Studies

    DEFF Research Database (Denmark)

    Holm, Jesper

    We will in this paper approach the challenge of building integrated environmental studies by presenting a crude frame of analysis which take into account both the physical aspects and the social-discursive articulations of environmental problems. This framework partly mirrors the approach of our...... department (Dept. of Environment, Technology and Social Studies, Roskilde University), and has originally in another version been presented in the book “Miljøregulering - tværvidenskabelige studier (Environmental Regulation. Interdisciplinary Studies)” (Holm, Kjærgård & Pedersen eds. 1997, in Danish) written...

  10. Tropical Zero Energy Office Building

    DEFF Research Database (Denmark)

    Reimann, Gregers Peter; Kristensen, Poul Erik

    2006-01-01

    The new headquarter for Pusat Tenaga Malaysia is designed to be a Zero Emission Office Building (ZEO). A full range of passive and active energy efficiency measures are implemented such that the building will need no more electricity than what can be produced via its own Building Integrated PV...... system. The overall objective of the project is to achieve zero energy consumption at lowest possible initial investments. The ZEO Building shows implementation of integrated design concepts, where active and passive energy systems are interwoven into the building itself, and where several building...... by daylight, supplemented by electric lighting during very dark and overcast periods. Extensive active energy efficiency measures are implemented in the building in order to reduce the need for electricity to an absolute minimum, without compromising the request for comfortable temperatures and adequate...

  11. Structural building screening and evaluation

    Science.gov (United States)

    Kurniawandy, Alex; Nakazawa, Shoji; Hendry, Andy; Ridwan, Firdaus, Rahmatul

    2017-10-01

    An earthquake is a disaster that can be harmful to the community, such as financial loss and also dead injuries. Pekanbaru is a city that located in the middle of Sumatera Island. Even though the city of Pekanbaru is a city that rarely occurs earthquake, but Pekanbaru has ever felt the impact of the big earthquake that occurred in West Sumatera on September 2009. As we know, Indonesia located between Eurasia plate, Pacific plate, and Indo-Australian plate. Particularly the Sumatera Island, It has the Semangko fault or the great Sumatra fault along the island from north to south due to the shift of Eurasia and Indo-Australian Plates. An earthquake is not killing people but the building around the people that could be killing them. The failure of the building can be early prevented by doing an evaluation. In this research, the methods of evaluation have used a guideline for the Federal Emergency Management Agency (FEMA) P-154 and Applied Technology Council (ATC) 40. FEMA P-154 is a rapid visual screening of buildings for potential seismic hazards and ATC-40 is seismic evaluation and retrofit of Concrete Buildings. ATC-40 is a more complex evaluation rather than FEMA P-154. The samples to be evaluated are taken in the surroundings of Universitas Riau facility in Pekanbaru. There are four buildings as case study such as the rent student building, the building of mathematics and natural science faculty, the building teacher training and education faculty and the buildings in the faculty of Social political sciences. Vulnerability for every building facing an earthquake is different, this is depending on structural and non-structural components of the building. Among all of the samples, only the building of mathematics and the natural science faculty is in critical condition according to the FEMA P-154 evaluation. Furthermore, the results of evaluation using ATC-40 for the teacher training building are in damage control conditions, despite the other three buildings are

  12. Building and using binoscopes

    CERN Document Server

    Butler, Norman

    2017-01-01

    Covering both homemade and commercial products, this book provides the reader with simple and straightforward information about the modeling, building, and use of binoscopes. Binoscopes can be thought of as binoculars enlarged to the size of telescopes - essentially, a combination of the two.  Constructing a binoscope is easier than most people think, but it still demands attention to detail and proper background knowledge. The author goes on to provide additional information about the products currently on the market, should the reader choose to purchase one instead of building it. Lastly, the book also compares binoscopes with telescopes in great detail, outlining the differences the reader can expect to see in the night sky from using both. The celestial views obtained with a binoscope, compared to a single telescope of the same aperture, are a very different experience. The new edition emphasizes the obvious advantages of viewing celestial objects through a binoscope. There are also many new photo...

  13. Irregular Shaped Building Design Optimization with Building Information Modelling

    Directory of Open Access Journals (Sweden)

    Lee Xia Sheng

    2016-01-01

    Full Text Available This research is to recognise the function of Building Information Modelling (BIM in design optimization for irregular shaped buildings. The study focuses on a conceptual irregular shaped “twisted” building design similar to some existing sculpture-like architectures. Form and function are the two most important aspects of new buildings, which are becoming more sophisticated as parts of equally sophisticated “systems” that we are living in. Nowadays, it is common to have irregular shaped or sculpture-like buildings which are very different when compared to regular buildings. Construction industry stakeholders are facing stiff challenges in many aspects such as buildability, cost effectiveness, delivery time and facility management when dealing with irregular shaped building projects. Building Information Modelling (BIM is being utilized to enable architects, engineers and constructors to gain improved visualization for irregular shaped buildings; this has a purpose of identifying critical issues before initiating physical construction work. In this study, three variations of design options differing in rotating angle: 30 degrees, 60 degrees and 90 degrees are created to conduct quantifiable comparisons. Discussions are focused on three major aspects including structural planning, usable building space, and structural constructability. This research concludes that Building Information Modelling is instrumental in facilitating design optimization for irregular shaped building. In the process of comparing different design variations, instead of just giving “yes or no” type of response, stakeholders can now easily visualize, evaluate and decide to achieve the right balance based on their own criteria. Therefore, construction project stakeholders are empowered with superior evaluation and decision making capability.

  14. Commercial Building Energy Asset Score

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-26

    This software (Asset Scoring Tool) is designed to help building owners and managers to gain insight into the as-built efficiency of their buildings. It is a web tool where users can enter their building information and obtain an asset score report. The asset score report consists of modeled building energy use (by end use and by fuel type), building systems (envelope, lighting, heating, cooling, service hot water) evaluations, and recommended energy efficiency measures. The intended users are building owners and operators who have limited knowledge of building energy efficiency. The scoring tool collects minimum building data (~20 data entries) from users and build a full-scale energy model using the inference functionalities from Facility Energy Decision System (FEDS). The scoring tool runs real-time building energy simulation using EnergyPlus and performs life-cycle cost analysis using FEDS. An API is also under development to allow the third-party applications to exchange data with the web service of the scoring tool.

  15. Building Brand Power

    Science.gov (United States)

    Lakshmi, S.; Muthumani, S., Dr.

    2017-05-01

    Brand power is established through brand awareness. It’s all about making consumers familiar about their products and services. Marketing strategies should make the customers extend the positive approach towards brand and continue through repeated purchases. There is a triple perspective approach to investigate the brand awareness in this research. The brand awareness and brand equity are studied and the relationship between those are analyzed. This also drills down about the brand performance and knowledge with awareness which tries to find out the brands value and utility among the public. Continuous improvement on package design, quality and buying experience will lead to customer loyalty and preference. Branding should happen though creative ads, eye catchers and special campaigns. Brand awareness is the extent to which consumers are familiar with their product or services. Power of a brand is resides in the minds of the customers. To build a strong brand, it is one of the great challenge for the marketers to ensure that customers have the right experiences with products and services and various marketing programs. So that tenderness, beliefs, perspective, perception and so on linked to the brand. If we are presenting the brand with no enthusiasm or spunk, people are going to forget about our brand. Even though that may seem harsh, it’s the naked truth in today’s marketing world. Brand must reach out to the community by special events, creating campaigns to keep the brand relevant also offer customer a unique experience. Here we study about the brand consciousness and to identify the cohesion between brand awareness with knowledge and performance and also to assess the effect of brand awareness on consumer purchase. In this study we necessary statistical tools like chi-square test ad t-test has been used to analyse the collected data. It is highly recommend to increase brand awareness, the marketers are constantly required to build brand awareness both

  16. Energy Efficiency, Building Productivity and the Commercial Buildings Market

    Energy Technology Data Exchange (ETDEWEB)

    Jones, D.W.

    2002-05-16

    The energy-efficiency gap literature suggests that building buyers are often short-sighted in their failure to apply life-cycle costing principles to energy efficient building technologies, with the result that under investment in these advanced technology occurs. This study examines the reasons this behavior may occur, by analyzing the pressures that market forces place on purchasers of buildings. Our basic conclusion is that the fundamental manner in which the buildings sector does business creates pressures to reduce initial capital outlays and to hedge against a variety of risks, including the ability of building owners to capture benefits from energy efficiency. Starting from the position that building buyers' willingness to pay drives choices over building attributes, we examine basic market principles, the structure of the buildings market, including the role of lenders, and policies that promote penetration of energy efficient technologies. We conclude that greater attention to buyers, and to the incentives and constraints they face, would promote a better understanding of building investment choices and contribute to better policies to promote the penetration of these technologies into markets.

  17. Building America Case Study: Solar Water Heating in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    R. Aldrich and J. Williamson

    2016-05-01

    Solar domestic hot water (SDHW) systems have been installed on buildings for decades, but because of relatively high costs they have not achieved significant market penetration in most of the country. As more buildings move towards zero net energy consumption, however, many designers and developers are looking more closely at SDHW. In multifamily buildings especially, SDHW may be more practical for several reasons: (1) When designing for zero net energy consumption, solar water heating may be part of the lowest cost approach to meet water heating loads. (2.) Because of better scale, SDHW systems in multifamily buildings cost significantly less per dwelling than in single-family homes. (3) Many low-load buildings are moving away from fossil fuels entirely. SDHW savings are substantially greater when displacing electric resistance water heating. (4) In addition to federal tax incentives, some states have substantial financial incentives that dramatically reduce the costs (or increase the benefits) of SDHW systems in multifamily buildings. With support form the U.S. DOE Building America program, the Consortium for Advanced Residential Buildings (CARB) worked with a developer in western Massachusetts to evaluate a SDHW system on a 12-unit apartment building. Olive Street Development completed construction in spring of 2014, and CARB has been monitoring performance of the water heating systems since May 2014.

  18. Building worldly insights.

    Science.gov (United States)

    Tremblay, Michael

    2017-07-01

    This article offers health leaders in Canada an opportunity to build a more worldly understanding of healthcare challenges. The focus is on post-conflict countries and island/small countries. Small and island countries often depend on other countries for their workforce and for specialist healthcare services. Conflict usually undermines if it doesn't destroy a country's healthcare system. Small and island countries offer opportunities for the majority of Canadian provinces and territories to develop new approaches from novel comparator countries, with which they may have more in common. Post-conflict countries offer an opportunity to consider the applicability of the determinants of policy and institutional failure to Aboriginal healthcare in Canada.

  19. Photovoltaic building blocks

    DEFF Research Database (Denmark)

    Hanberg, Peter Jesper; Jørgensen, Anders Michael

    2014-01-01

    efficiency of about 15% for commercial Silicon solar cells there is still much to gain. DTU Danchip provides research facilities, equipment and expertise for the building blocks that comprises fabricating the efficient solar cell. In order to get more of the sun light into the device we provide thin film...... coating tools to depositand develop anti-reflection filters by means of sputtering or e-beam evaporation. To reduce the area taken up by metallic contacts transparent conducting oxides like Aluminium doped ZincOxide (AZO) and Indium Tin Oxide (ITO) can be deposited. We also support research.......7%2. Such efforts we also provide service for through our tools designed for this material system.Our team of process generalists can guide and advice you to utilize our clean room facilities most efficiently while our process specialists can help you to develop new processes and fabrication recipes. Our dedicated...

  20. Building Land Information Policies

    DEFF Research Database (Denmark)

    Enemark, Stig

    2004-01-01

    The paper presents a conceptual understanding in the areas of Cadastre, Land Administration, and Land Management as a basis for building adequate land information policies. To develop this understanding the paper looks at each area as a system or an infrastructure designed for handling specific...... and judicial setting of the individual country. However, in spite of the different origins, the systems seem to merge into a global model serving some basic societal needs. The paper presents an outline of this development towards a global model for sustainable land administration infrastructures...... of measurement science, spatial information, management, and land management. (2) To establish national professional associations which accommodate a modern interdisciplinary profile. (3) To assess the capacity needs in land administration and to develop the capacity needed at societal, institutional...

  1. Energy Performance of Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per

    2007-01-01

    programme (ECCP) was established in June 2000 to help identify the most environmentally cost-effective measures enabling the EU to meet its target under the Kyoto Protocol, namely an 8% reduction in greenhouse gas emissions from 1990 levels by 2012. Energy use in buildings accounts for almost half of all CO......"Sustainable development" has been defined best by the Brundtland Commission as "development that meets the needs of the present without compromising the ability of future generations to meet their own needs". Adequate and affordable energy supplies have been key to economic development...... and are central to improving social and economic well- being, and human welfare and raising living standards. Even if energy is essential for development, it is only a means to an end. The end is good health, high living standards, a sustainable economy and a clean environment. The European Climate change...

  2. Renovating the Main Building

    CERN Document Server

    CERN Bulletin

    2010-01-01

    CERN's "Main Building" is exactly that. The Organization's central hub, with hundreds of staff and visitors passing through its doors every day, will soon be getting a well-earned facelift. Refurbishment work will proceed in phases, starting with the Salle des Pas Perdus, the concourse between the Council Chamber and the Main Auditorium. By the end of August, informal seating areas will be installed, electronic display panels will provide practical information and improved sound insulation will enhance conditions in the auditoria and surrounding meeting rooms.   In light green the area that will undergo the facelift. Work will start in July. The ground floor is home to the entrance to Restaurant No. 1, the bank, the post office, the travel agent, the Users Office, the Staff Association, the notice boards etc. Step up to the first floor to access CERN's largest lecture theatre, the Council Chamber and its "Pas Perdus" lobby. Everyone who works at or visits CERN i...

  3. Guidelines for Building Science Education

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, Cheryn E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rashkin, Samuel [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Huelman, Pat [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-11-01

    The U.S. Department of Energy’s (DOE) residential research and demonstration program, Building America, has triumphed through 20 years of innovation. Partnering with researchers, builders, remodelers, and manufacturers to develop innovative processes like advanced framing and ventilation standards, Building America has proven an energy efficient design can be more cost effective, healthy, and durable than a standard house. As Building America partners continue to achieve their stretch goals, they have found that the barrier to true market transformation for high performance homes is the limited knowledge-base of the professionals working in the building industry. With dozens of professionals taking part in the design and execution of building and selling homes, each person should have basic building science knowledge relevant to their role, and an understanding of how various home components interface with each other. Instead, our industry typically experiences a fragmented approach to home building and design. After obtaining important input from stakeholders at the Building Science Education Kick-Off Meeting, DOE created a building science education strategy addressing education issues preventing the widespread adoption of high performance homes. This strategy targets the next generation and provides valuable guidance for the current workforce. The initiative includes: • Race to Zero Student Design Competition: Engages universities and provides students who will be the next generation of architects, engineers, construction managers and entrepreneurs with the necessary skills and experience they need to begin careers in clean energy and generate creative solutions to real world problems. • Building Science to Sales Translator: Simplifies building science into compelling sales language and tools to sell high performance homes to their customers. • Building Science Education Guidance: Brings together industry and academia to solve problems related to

  4. Building Energy Monitoring and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Tianzhen; Feng, Wei; Lu, Alison; Xia, Jianjun; Yang, Le; Shen, Qi; Im, Piljae; Bhandari, Mahabir

    2013-06-01

    This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.

  5. Capacity Building in Land Management

    DEFF Research Database (Denmark)

    Enemark, Stig; Ahene, Rexford

    2003-01-01

    development in this area. Furthermore, capacity building should ensure that the focus is on building sound institutions and governance rather than just high-level IT-infrastructures.    This overall approach to capacity building in land management is used for implementing a new land policy reform in Malawi......There is a significant need for capacity building in the interdisciplinary area of land management especially in developing countries and countries in transition, to deal with the complex issues of building efficient land information systems and sustainable institutional infrastructures. Capacity...... building in land management is not only a question of establishing a sufficient technological level or sufficient economic resources. It is mainly a question of understanding the interdisciplinary and cross-sectoral nature of land administration systems, and understanding the need for human resource...

  6. The NIST Green Building Program

    Energy Technology Data Exchange (ETDEWEB)

    Hill, J.E. [National Institute of Standards and Technology (NIST), Gaithersburg, MD (United States)

    1994-12-31

    For over 2 decades, NIST has been involved in energy conservation programs. NIST`s current programs broadly span the areas from waste minimization to air, soil, water, indoor air quality, ozone depletion, and global warming. The latest endeavor NIST is undertaking is the {open_quotes}Green Building Program{close_quotes} in which NIST is at the forefront of designing buildings using environmentally safe materials. NIST`s program has two components. The laboratory-based activities involve NIST staff working directly with manufacturers and designers to develop technologies conducive to energy efficiency. The second component, demonstration buildings, includes environmentally safe buildings which are monuments to green technologies. These buildings not only demonstrate cost effectiveness and evaluate green technologies, they also identify new technologies needed to develop an effective green building.

  7. User Driven Innovative Building Design

    DEFF Research Database (Denmark)

    Christiansson, Per; Sørensen, Kristian Birch; Steffensen, K. G.

    2009-01-01

    to the broad introduction of advanced information and communication technology (ICT). VICMET is a general method for user involvement in every phase of the construction process and with a unique setup for each type of user. VICMET can use already created information in the building process and emphasis...... that the users are the key to next level of successful building projects. VICMET defines four spaces to support the activities in a innovative/creative design process; The Contextual Inquiry Space, the Conceptual Modeling and Game Space, the Functional Building Systems (FBS) Consolidation Space, and the Solution......During recent years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as on the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due...

  8. Mould growth on building materials

    DEFF Research Database (Denmark)

    Fog Nielsen, K.

    Mould growth in buildings is associated with adverse health effects among the occupants of the building. However actual growth only occurs in damp and water-damaged materials, and is an increasing problem in Denmark, due to less robust constructions, inadequate maintenance, and too little...... ventilation. This project was started to determine if mycotoxins are produced in damp and water-damaged buildings as well investigating the influence of environmental conditions (humidity and temperature) on the production of fungal growth and secondary metabolism....

  9. Buildings Lean Maintenance Implementation Model

    Science.gov (United States)

    Abreu, Antonio; Calado, João; Requeijo, José

    2016-11-01

    Nowadays, companies in global markets have to achieve high levels of performance and competitiveness to stay "alive".Within this assumption, the building maintenance cannot be done in a casual and improvised way due to the costs related. Starting with some discussion about lean management and building maintenance, this paper introduces a model to support the Lean Building Maintenance (LBM) approach. Finally based on a real case study from a Portuguese company, the benefits, challenges and difficulties are presented and discussed.

  10. Electric Propulsion Research Building (EPRB)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electric Propulsion Research Building (EPRB) capability centers on its suite of vacuum chambers, which are configured to meet the unique requirements related to...

  11. Energy Innovations for Healthy Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Bogucz, Edward A. [Syracuse Univ., NY (United States)

    2016-09-23

    Healthy buildings provide high indoor environmental quality for occupants while simultaneously reducing energy consumption. This project advanced the development and marketability of envisioned healthy, energy-efficient buildings through studies that evaluated the use of emerging technologies in commercial and residential buildings. The project also provided resources required for homebuilders to participate in DOE’s Builders Challenge, concomitant with the goal to reduce energy consumption in homes by at least 30% as a first step toward achieving envisioned widespread availability of net-zero energy homes by 2030. In addition, the project included outreach and education concerning energy efficiency in buildings.

  12. Energy conservation in large buildings

    Science.gov (United States)

    Rosenfeld, A.; Hafemeister, D.

    1985-11-01

    As energy prices rise, newly energy aware designers use better tools and technology to create energy efficient buildings. Thus the U.S. office stock (average age 20 years) uses 250 kBTU/ft2 of resource energy, but the guzzler of 1972 uses 500 (up×2), and the 1986 ASHRAE standards call for 100-125 (less than 25% of their 1972 ancestors). Surprisingly, the first real cost of these efficient buildings has not risen since 1972. Scaling laws are used to calculate heat gains and losses of buildings to obtain the ΔT(free) which can be as large as 15-30 °C (30-60 °F) for large buildings. The net thermal demand and thermal time constants are determined for the Swedish Thermodeck buildings which need essentially no heat in the winter and no chillers in summer. The BECA and other data bases for large buildings are discussed. Off-peak cooling for large buildings is analyzed in terms of saving peak-electrical power. By downsizing chillers and using cheaper, off-peak power, cost-effective thermal storage in new commercial buildings can reduce U.S. peak power demands by 10-20 GW in 15 years. A further potential of about 40 GW is available from adopting partial thermal storage and more efficient air conditioners in existing buildings.

  13. Building Energy Monitoring and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Tianzhen; Feng, Wei; Lu, Alison; Xia, Jianjun; Yang, Le; Shen, Qi; Im, Piljae; Bhandari, Mahabir

    2013-06-01

    U.S. and China are the world’s top two economics. Together they consumed one-third of the world’s primary energy. It is an unprecedented opportunity and challenge for governments, researchers and industries in both countries to join together to address energy issues and global climate change. Such joint collaboration has huge potential in creating new jobs in energy technologies and services. Buildings in the US and China consumed about 40% and 25% of the primary energy in both countries in 2010 respectively. Worldwide, the building sector is the largest contributor to the greenhouse gas emission. Better understanding and improving the energy performance of buildings is a critical step towards sustainable development and mitigation of global climate change. This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.

  14. Descent in buildings (AM-190)

    CERN Document Server

    Mühlherr, Bernhard; Weiss, Richard M

    2015-01-01

    Descent in Buildings begins with the resolution of a major open question about the local structure of Bruhat-Tits buildings. The authors then put their algebraic solution into a geometric context by developing a general fixed point theory for groups acting on buildings of arbitrary type, giving necessary and sufficient conditions for the residues fixed by a group to form a kind of subbuilding or "form" of the original building. At the center of this theory is the notion of a Tits index, a combinatorial version of the notion of an index in the relative theory of algebraic groups. These results

  15. Lifetime environmental impact of buildings

    CERN Document Server

    Mequignon, Marc

    2014-01-01

    This work discusses the impact of the life of buildings on? sustainable development methods.?The study of the lifespan of the building is used to assess and?manage the environmental impacts associated?with all the stages of a product's life, from raw material extraction?through to repair, maintenance and?? 'end of life' scenarios. While several papers have discussed thegreenhouse gas emissions of buildings,?less research has been done on how these are affected by the lifespan?of the building. This book serves to?highlight the pertinence of this factor and contributes to providing?new ideas on

  16. Better Buildings NW Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Kevin [Toledo-Lucas County Port Authority, Toledo, OH (United States)

    2015-03-04

    When the Toledo Lucas County Port Authority (TLCPA) filed for the Department of Energy EECBG grant in late 2009, it was part of a strategic and Board backed objective to expand the organization’s economic development and financing programs into alternative energy and energy efficiency. This plan was filed with the knowledge and support of the areas key economic development agencies. The City of Toledo was also a key partner with the Mayor designating a committee to develop a Strategic Energy Policy for the City. This would later give rise to a Community Sustainability Strategic Plan for Toledo, Lucas County and the surrounding region with energy efficiency as a key pillar. When the TLCPA signed the grant documents with the DOE in June of 2010, the geographic area was severely distressed economically, in the early stages of a recovery from over a 30% drop in business activity and high unemployment. The TLCPA and its partners began identifying potential project areas well before the filing of the application, continuing to work diligently before the formal award and signing of the grant documents. Strong implementation and actions plans and business and financing models were developed and revised throughout the 3 year grant period with the long term goal of creating a sustainable program. The TLCPA and the City of Toledo demonstrated early leadership by forming the energy improvement district and evaluating buildings under their control including transportation infrastructure and logistics, government services buildings and buildings which housed several for profit and not for profit tenants while completing significant energy efficiency projects that created public awareness and confidence and solid examples of various technologies and energy savings. As was stated in the DOE Award Summary, the undertaking was focused as a commercial program delving into Alternative Energy Utility Districts; what are referred to in Ohio Statute as Energy Special Improvement

  17. Building guide : how to build Xyce from source code.

    Energy Technology Data Exchange (ETDEWEB)

    Keiter, Eric Richard; Russo, Thomas V.; Schiek, Richard Louis; Sholander, Peter E.; Thornquist, Heidi K.; Mei, Ting; Verley, Jason C.

    2013-08-01

    While Xyce uses the Autoconf and Automake system to configure builds, it is often necessary to perform more than the customary %E2%80%9C./configure%E2%80%9D builds many open source users have come to expect. This document describes the steps needed to get Xyce built on a number of common platforms.

  18. Natural Hazards Evaluation of Existing Buildings. Building Science Series 61.

    Science.gov (United States)

    Culver, Charles G.; And Others

    A methodology is presented for survey and evaluation of existing buildings to determine the risk to life safety under natural hazard conditions and estimate the amount of expected damage. Damage to both structural and nonstructural building components resulting from the extreme natural environments encountered in earthquakes, hurricanes, and…

  19. Bore pile foundation tall buildings closed in the heritage building

    Science.gov (United States)

    Triastuti, Nusa Setiani

    2017-11-01

    Bore pile foundation for high building surroundings heritage building should be not damage. Construction proses must good, no necking, no mixed deep water, no sliding soil, nonporous concrete. Objective the execution of bore pile so that heritage buildings and neighboring buildings that are old do not experience cracks, damage and tilting. The survey methodology was observe the process of the implementation of the dominant silt, clay soil, in addition a limited space and to analyze the results of loading tests, investigations of soil and daily reports. Construction process determines the success of the structure bore pile in high building structure bearing, without damaging a heritage building. Attainment the hard soil depth, density concrete, observable clean reinforcement in the implementation. Monitoring the implementation of, among others, the face of the ground water little reduce in the area and outside the footprint of the building, no impact of vibration drilling equipment, watching the mud content on the water coming out at the time of drilling, concrete volume was monitored each 2 m bore depth of pile, The result researched heritage building was not damage. The test results bore pile axial, lateral analyzed the results have the appropriate force design required.

  20. Virtual building environments (VBE) - Applying information modeling to buildings

    Energy Technology Data Exchange (ETDEWEB)

    Bazjanac, Vladimir

    2004-06-21

    A Virtual Building Environment (VBE) is a ''place'' where building industry project staffs can get help in creating Building Information Models (BIM) and in the use of virtual buildings. It consists of a group of industry software that is operated by industry experts who are also experts in the use of that software. The purpose of a VBE is to facilitate expert use of appropriate software applications in conjunction with each other to efficiently support multidisciplinary work. This paper defines BIM and virtual buildings, and describes VBE objectives, set-up and characteristics of operation. It informs about the VBE Initiative and the benefits from a couple of early VBE projects.

  1. Capacity building for HIA

    Directory of Open Access Journals (Sweden)

    Gabriel Gulis PhD

    2007-09-01

    Full Text Available

    Background: To integrate health impact assessment (HIA into existing decision-making processes requires not only methods and procedures but also well-trained experts, aware policy makers and appropriate institutions. Capacity building is the assistance which is provided to entities, which have a need to develop a certain skill or competence, or for general upgrading of performance ability. If a new technique is planned to be introduced there is a need for capacity building with no respect to levels (local, regional, national, international or sectors (health, environment, finance, social care, education, etc.. As such, HIA is a new technique for most of the new Member States and accession countries of the European Union.

    Methods: To equip individuals with the understanding and skills needed to launch a HIA or be aware of the availability of this methodology and to access information, knowledge and training, we focused on the organization of workshops in participating countries. The workshops served also as pilot events to test a “curriculum” for HIA; a set of basic topics and presentations had been developed to be tested during workshops. In spite of classical in-class workshops we aimed to organize e-learning events as a way to over come the “busyness” problem of decision makers.

    Results: Throughout March – October 2006 we organized and ran 7 workshops in Denmark, Turkey, Lithuania, Poland, Bulgaria, Slovak Republic and Hungary. Participants came from the public health sector (141, non-public health decision makers (113 and public health students (100. A concise curriculum was developed and tested during these workshops. Participants developed a basic understanding of HIA, skills to develop and use their own screening tools as well as scoping.Within the workshop in Denmark we tested an online, real-time Internet based training method; participants highly welcomed this

  2. INL High Performance Building Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer D. Morton

    2010-02-01

    High performance buildings, also known as sustainable buildings and green buildings, are resource efficient structures that minimize the impact on the environment by using less energy and water, reduce solid waste and pollutants, and limit the depletion of natural resources while also providing a thermally and visually comfortable working environment that increases productivity for building occupants. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish this mission. This infrastructure, particularly the buildings, should incorporate high performance sustainable design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. Additionally, INL is a large consumer of energy that contributes to both carbon emissions and resource inefficiency. In the current climate of rising energy prices and political pressure for carbon reduction, this guide will help new construction project teams to design facilities that are sustainable and reduce energy costs, thereby reducing carbon emissions. With these concerns in mind, the recommendations described in the INL High Performance Building Strategy (previously called the INL Green Building Strategy) are intended to form the INL foundation for high performance building standards. This revised strategy incorporates the latest federal and DOE orders (Executive Order [EO] 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” [2009], EO 13423, “Strengthening Federal Environmental, Energy, and Transportation Management” [2007], and DOE Order 430.2B, “Departmental Energy, Renewable Energy, and Transportation Management” [2008]), the latest guidelines, trends, and observations in high performance building construction, and the latest changes to the Leadership in Energy and Environmental Design

  3. Building envelope for New Buildings and Energy Renovation of Existing Buildings. Project results

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian; Rose, Jørgen; Esbensen, Peter Kjær

    1999-01-01

    , a group of scientists at the Department of Buildings and Energy, Technical University of Denmark, have started a research project to develop better solutions for new building and energy renovation.The publication report the status after the first 3 year of the Building Envelope Project with emphasis...... on the following subjects:Scientific basis for calculation programs, Development of calculationsmethods for heat transfer, Development of new building envelope components, Roofing system based on wooden roof elements, Roofing system with drying properties, Moisture uptake and drying from brick constructions...

  4. 309 Building transition plan

    Energy Technology Data Exchange (ETDEWEB)

    Graves, C.E.

    1994-08-31

    The preparation for decontamination and decommissioning (transition) of the 309 Building is projected to be completed by the end of the fiscal year (FY) 1998. The major stabilization and decontamination efforts include the Plutonium Recycle Test Reactor (PRTR), fuel storage and transfer pits, Transfer Waste (TW) tanks and the Ion Exchange Vaults. In addition to stabilizing contaminated areas, equipment, components, records, waste products, etc., will be dispositioned. All nonessential systems, i.e., heating, ventilation, and air conditioning (HVAC), electrical, monitoring, fluids, etc., will be shut down and drained/de-energized. This will allow securing of the process, laboratory, and office areas of the facility. After that, the facility will be operated at a level commensurate with its surveillance needs while awaiting D&D. The implementation costs for FY 1995 through FY 1998 for the transition activities are estimated to be $1,070K, $2,115K, $2,939K, and $4,762K, respectively. Costs include an assumed company overhead of 20% and a 30% out year contingency.

  5. Nuclear reactor building

    Science.gov (United States)

    Gou, P.F.; Townsend, H.E.; Barbanti, G.

    1994-04-05

    A reactor building for enclosing a nuclear reactor includes a containment vessel having a wetwell disposed therein. The wetwell includes inner and outer walls, a floor, and a roof defining a wetwell pool and a suppression chamber disposed there above. The wetwell and containment vessel define a drywell surrounding the reactor. A plurality of vents are disposed in the wetwell pool in flow communication with the drywell for channeling into the wetwell pool steam released in the drywell from the reactor during a LOCA for example, for condensing the steam. A shell is disposed inside the wetwell and extends into the wetwell pool to define a dry gap devoid of wetwell water and disposed in flow communication with the suppression chamber. In a preferred embodiment, the wetwell roof is in the form of a slab disposed on spaced apart support beams which define there between an auxiliary chamber. The dry gap, and additionally the auxiliary chamber, provide increased volume to the suppression chamber for improving pressure margin. 4 figures.

  6. Building a crystal palace

    CERN Multimedia

    2007-01-01

    The end-caps of the CMS electromagnetic calorimeter (ECAL) take shape as the first quadrant was completed on Wednesday 3 October. 1831 crystals, organised into five by five blocks named ‘supercrystals’, make up the first quadrant of Dee 1.With the 61,200-crystal barrel of its electromagnetic calorimeter (ECAL) complete, CMS is now building the endcaps, on the tenth anniversary of their initial design. Crystals for the endcaps were the last to be made, so the race is now on to have them all in place and ready for the turn-on of the LHC next year. Assembly of the first of eight quadrants began in June and crystal mounting was completed on Wednesday 3 October. Each crystal is transparent, has a volume just larger than a CERN coffee cup yet weighs a huge 1.5kg. 1831 of these lead tungstate crystals went into the first quadrant from a total 14,648 in the endcaps. The lead and tungsten account for 86% of each crystal’s weight, but as project leader Dave Cockerill expl...

  7. Strengthening Building Retrofit Markets

    Energy Technology Data Exchange (ETDEWEB)

    Templeton, Mary [Michigan Saves; Jackson, Robert [Michigan Energy Office

    2014-04-15

    The Business Energy Financing (BEF) program offered commercial businesses in Michigan affordable financing options and other incentives designed to support energy efficiency improvements. We worked through partnerships with Michigan utilities, lenders, building contractors, trade associations, and other community organizations to offer competitive interest rates and flexible financing terms to support energy efficiency projects that otherwise would not have happened. The BEF program targeted the retail food market, including restaurants, grocery stores, convenience stores, and wholesale food vendors, with the goal of achieving energy efficiency retrofits for 2 percent of the target market. We offered low interest rates, flexible payments, easy applications and approval processes, and access to other incentives and rebates. Through these efforts, we sought to help customers strive for energy savings retrofits that would save 20 percent or more on their energy use. This program helped Michigan businesses reduce costs by financing energy efficient lighting, heating and cooling systems, insulation, refrigeration, equipment upgrades, and more. Businesses completed the upgrades with the help of our authorized contractors, and, through our lending partners, we provided affordable financing options.

  8. Building and Using Binoscopes

    Science.gov (United States)

    Butler, Norman

    What are "binoscopes of the third kind"? Binoscopes for the most part can be either commercial (first kind) or homemade (second kind). But there are a lot of binoscopes out there in telescope land that are both. The author likes to call these kinds of binoscopes simply "binoscopes of the third kind." They can have a varied combination of parts or accessories that are both homemade and commercial and still can be a lot of fun to build and use for astronomy. These types of binoscopes can have mounts that are commercial but have homemade optical systems. Or they can have mounts that are homemade but carry commercial optical tube assemblies. Either way, "binoscopes of the third kind" can have a little of both built in the way of commercial and homemade qualities (see Fig. 10.28). For the most part, it doesn't have to be necessarily a binoscope either. It can be anything associated with and/or used for binocular or binoscope astronomy in general. So has a new binoscope ATM astro-term been "coined" here? Probably not. And even if for some reason it never catches on as a new "household word," the author won't be too disappointed.

  9. The building is the program

    CSIR Research Space (South Africa)

    Smith, Andrew C

    2013-09-01

    Full Text Available We present interaction with a physical building as a hypothetical example of peripheral interaction. The state of the building's windows provides input to an algorithm which produces abstract art as the result of the interaction. This paper assumes...

  10. Simulating Building Fires for Movies

    Science.gov (United States)

    Rodriguez, Ricardo C.; Johnson, Randall P.

    1987-01-01

    Fire scenes for cinematography staged at relatively low cost in method that combines several existing techniques. Nearly realistic scenes, suitable for firefighter training, produced with little specialized equipment. Sequences of scenes set up quickly and easily, without compromising safety because model not burned. Images of fire, steam, and smoke superimposed on image of building to simulate burning of building.

  11. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...

  12. Simplified building model of districts

    NARCIS (Netherlands)

    Koene, F.G.H.; Bakker, L.G.; Lanceta, D.; Narmsara, S.

    2014-01-01

    In the setting of this paper, a building is represented by a simple model consisting of two thermal masses. Generic values were obtained for two unknown parameters in the model, capable of representing an office building, a single family dwelling and a multifamily dwelling, at three levels of

  13. Building on piles in floodplains

    NARCIS (Netherlands)

    Harke, J.; van der Maarel, A.J.G.; Schielen, Ralph Mathias Johannes; Ribberink, Jan S.; Augustijn, Dionysius C.M.; van Os, A.G.

    2007-01-01

    Last year in the Netherlands 15 locations were allocated along the Rhine branches where – under strong restrictions - it was allowed to build in floodplains. Building in floodplains may lead to a water level rise during floods and moreover, the river bed morphology may be disturbed

  14. New scripts for old buildings

    NARCIS (Netherlands)

    Tineke van der Schoor

    2013-01-01

    STS and Energy, Lisbon 2013 Historical buildings are an important source of local identity and form a connection to our past. It is a EU policy objective to conserve and redesign heritage buildings like prisons, military barracks, factories, stations, and schools. Such redesign should also ensure

  15. Federal Buildings Supplemental Survey 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The Energy Information Administration (EIA) of the US Department of Energy (DOE) is mandated by Congress to be the agency that collects, analyzes, and disseminates impartial, comprehensive data about energy including the volume consumed, its customers, and the purposes for which it is used. The Federal Buildings Supplemental Survey (FBSS) was conducted by EIA in conjunction with DOE`s Office of Federal Energy Management Programs (OFEMP) to gain a better understanding of how Federal buildings use energy. This report presents the data from 881 completed telephone interviews with Federal buildings in three Federal regions. These buildings were systematically selected using OFEMP`s specifications; therefore, these data do not statistically represent all Federal buildings in the country. The purpose of the FBSS was threefold: (1) to understand the characteristics of Federal buildings and their energy use; (2) to provide a baseline in these three Federal regions to measure future energy use in Federal buildings as required in EPACT; and (3) to compare building characteristics and energy use with the data collected in the CBECS.

  16. Intelligent Buildings and pervasive computing

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Krogh, Peter Gall

    2001-01-01

    Intelligent Buildings have been the subject of research and commercial interest for more than two decades. The different perspectives range from monitoring and controlling energy consumption over interactive rooms supporting work in offices and leisure in the home, to buildings providing...

  17. Energy conservation in rented buildings

    Energy Technology Data Exchange (ETDEWEB)

    Klingberg, T.; Broechner, J.; Forsman, J.; Gaunt, L.; Holgersson, M.

    1984-08-01

    The bulletin is an anthology of nine essays by different authors addressing the issue of energy conservation in buildings, where there exists a landlord/tenant relationship. After an overview of the rental market and the stock of rental buildings different types of rental contracts and energy charges are described.

  18. Building Blocks for Personal Brands

    Science.gov (United States)

    Thomas, Lisa Carlucci

    2011-01-01

    In this article, the author discusses the four essential building blocks for personal brands: (1) name; (2) message; (3) channels; and (4) bridges. However, outstanding building materials can only take a person so far. The author emphasizes that vision, determination, faith, a sense of humor, and humility are also required.

  19. California commercial building energy benchmarking

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, Satkartar; Piette, Mary Ann

    2003-07-01

    Building energy benchmarking is the comparison of whole-building energy use relative to a set of similar buildings. It provides a useful starting point for individual energy audits and for targeting buildings for energy-saving measures in multiple-site audits. Benchmarking is of interest and practical use to a number of groups. Energy service companies and performance contractors communicate energy savings potential with ''typical'' and ''best-practice'' benchmarks while control companies and utilities can provide direct tracking of energy use and combine data from multiple buildings. Benchmarking is also useful in the design stage of a new building or retrofit to determine if a design is relatively efficient. Energy managers and building owners have an ongoing interest in comparing energy performance to others. Large corporations, schools, and government agencies with numerous facilities also use benchmarking methods to compare their buildings to each other. The primary goal of Task 2.1.1 Web-based Benchmarking was the development of a web-based benchmarking tool, dubbed Cal-Arch, for benchmarking energy use in California commercial buildings. While there were several other benchmarking tools available to California consumers prior to the development of Cal-Arch, there were none that were based solely on California data. Most available benchmarking information, including the Energy Star performance rating, were developed using DOE's Commercial Building Energy Consumption Survey (CBECS), which does not provide state-level data. Each database and tool has advantages as well as limitations, such as the number of buildings and the coverage by type, climate regions and end uses. There is considerable commercial interest in benchmarking because it provides an inexpensive method of screening buildings for tune-ups and retrofits. However, private companies who collect and manage consumption data are concerned that the

  20. Integrated Building Management System (IBMS)

    Energy Technology Data Exchange (ETDEWEB)

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  1. Augmented reality building operations tool

    Science.gov (United States)

    Brackney, Larry J.

    2014-09-09

    A method (700) for providing an augmented reality operations tool to a mobile client (642) positioned in a building (604). The method (700) includes, with a server (660), receiving (720) from the client (642) an augmented reality request for building system equipment (612) managed by an energy management system (EMS) (620). The method (700) includes transmitting (740) a data request for the equipment (612) to the EMS (620) and receiving (750) building management data (634) for the equipment (612). The method (700) includes generating (760) an overlay (656) with an object created based on the building management data (634), which may be sensor data, diagnostic procedures, or the like. The overlay (656) is configured for concurrent display on a display screen (652) of the client (642) with a real-time image of the building equipment (612). The method (700) includes transmitting (770) the overlay (656) to the client (642).

  2. Capacity Building in Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig; Williamson, I

    2004-01-01

    Capacity building increasingly seen as a key component of land administration projects in developing and countries in transition undertaken by the international development banks and individual country development assistance agencies. However, the capacity building concept is often used within...... infrastructures for implementing land policies in a sustainable way. Where a project is established to create land administration infrastructures in developing or transition countries, it is critical that capacity building is a mainstream component, not as an add-on, which is often the case. In fact such projects...... should be dealt with as capacity building projects in themselves.    The article introduces a conceptual analytical framework that provides some guidance when dealing with capacity building for land administration in support of a broader land policy agenda....

  3. Using Proteins to Build Nanocomputers

    Science.gov (United States)

    Laufenberg, Larry

    2003-01-01

    How low can we go? This is the question challenging scientists who want to build ever-smaller electronic components. As famed physicist Richard Feynmann said in 1959, 'there is plenty of room at the bottom,' meaning at the atomic or nanometric scale. But even Feynmann could only guess at how we might eventually build things 'down there.' As current lithographic techniques for etching semiconductor circuits rapidly approach their physical limits, scientists are looking for new and less expensive ways to fabricate circuits at infinitesimally small scales. NASA scientists have discovered a new tool that may help accomplish this goal - proteins. The basic building blocks of life may be harnessed to build computers and sensors on the nanoscale. Proteins provide self-assembling structures that can be engineered to build ordered arrays of quantum dots.

  4. Data management for biofied building

    Science.gov (United States)

    Matsuura, Kohta; Mita, Akira

    2015-03-01

    Recently, Smart houses have been studied by many researchers to satisfy individual demands of residents. However, they are not feasible yet as they are very costly and require many sensors to be embedded into houses. Therefore, we suggest "Biofied Building". In Biofied Building, sensor agent robots conduct sensing, actuation, and control in their house. The robots monitor many parameters of human lives such as walking postures and emotion continuously. In this paper, a prototype network system and a data model for practical application for Biofied Building is pro-posed. In the system, functions of robots and servers are divided according to service flows in Biofield Buildings. The data model is designed to accumulate both the building data and the residents' data. Data sent from the robots and data analyzed in the servers are automatically registered into the database. Lastly, feasibility of this system is verified through lighting control simulation performed in an office space.

  5. Integrating Environmentally Responsive Elements in Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per; Andresen, Inger; Perino, Marco

    2006-01-01

    Significant improvement have been achieved on efficiency improvements of specific building elements like the building envelope and building equipment and services and whilst most building elements still offer opportunities for efficiency improvements, the greatest future potential lie...... with technologies that promote the integration of responsive building elements and building services in integrated building concepts. In order to address some of these issues an international research effort, IEA-ECBCS Annex 44 has been initiated. The paper especially presents the annex activities regarding...

  6. Sustainability of higher educational buildings

    Directory of Open Access Journals (Sweden)

    Aboulnaga Mohsen

    2016-01-01

    Full Text Available Despite greenhouse gases (GHG emissions of Egypt represent nearly 1 percent of the World's GHG emissions, but according to IPCCC, Egypt is one of the nations that will be heavily affected by the impact of climate change risks. The global CO2 emissions from different sectors, buildings are forming the highest portion (about 5.5 GtCO2-eq. Electricity consumption in public buildings, including administrative, educational and health buildings (9 percent is the 2nd largest type after residential buildings (40 percent. The electrical energy per person in Egypt has increased from 1245 kWh in 2001/2002 to 1950 kWh in 2012/2013; an increase of 57 percent. This resulted in a colossal amount of CO2 emitted into the atmosphere. Thus, improving energy performance in residential and higher education buildings will have a significant impact on the reduction of electrical energy use, improve recourses efficiency and the nation's economic growth and footprint. Energy consumption in education buildings depends, mainly on the building's activities, time of use and influx of visitors and students and academic staff as well as the academic terms whether in winter summer. Retrofitting measures are important to reduce energy consumption in higher educational buildings and cooling requirements in hot climate. One of the most important measures in the retrofitting process of the building envelop, including its roof are mainly glazing type and characteristics, and walls’ thermal insulation. This paper addresses sustainability measures of the Faculty of Engineering Campus – Department of Architectural Engineering building at Cairo University, Egypt. The objective is to set the baseline assessment of the building’ energy use and compared it with its energy performance after retrofitting measures and simulation. Results show that applying these retrofitting measures; energy use has been reduced by 15 percent from the baseline (BAU energy use of an average of 14.6

  7. Energy use in office buildings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    This is the report on Task IB, Familiarization with Additional Data Collection Plans of Annual Survey of BOMA Member and Non-Member Buildings in 20 Cities, of the Energy Use in Office Buildings project. The purpose of the work was to monitor and understand the efforts of the Building Owners and Managers Association International (BOMA) in gathering an energy-use-oriented data base. In order to obtain an improved data base encompassing a broad spectrum of office space and with information suitable for energy analysis in greater detail than is currently available, BOMA undertook a major data-collection effort. Based on a consideration of geographic area, climate, population, and availability of data, BOMA selected twenty cities for data collection. BOMA listed all of the major office space - buildings in excess of 40,000 square feet - in each of the cities. Tax-assessment records, local maps, Chamber of Commerce data, recent industrial-development programs, results of related studies, and local-realtor input were used in an effort to assemble a comprehensive office-building inventory. In order to verify the accuracy and completeness of the building lists, BOMA assembled an Ad-Hoc Review Committee in each city to review the assembled inventory of space. A questionnaire on office-building energy use and building characteristics was developed. In each city BOMA assembled a data collection team operating under the supervision of its regional affiliate to gather the data. For each city a random sample of buildings was selected, and data were gathered. Responses for over 1000 buildings were obtained.

  8. Berkeley Lab to Help Build Straw Bale Building

    Energy Technology Data Exchange (ETDEWEB)

    Worsham, S.A.; Van Mechelen, G.

    1998-12-01

    The Shorebird Environmental Learning Center (SELC) is a new straw bale building that will showcase current and future technologies and techniques that will reduce the environmental impacts of building construction and operations. The building will also serve as a living laboratory to test systems and monitor their performance. The project will be the model for a building process that stops using our precious resources and reduces waste pollution. The rice straw that will be used for the bale construction is generally waste material that is typically burned--millions of tons of it a year--especially in California's San Joaquin Valley. Buildings have significant impacts on the overall environment. Building operations, including lighting, heating, and cooling, consume about 30% of the energy used in the United States. Building construction and the processes into making building materials consume an additional 8% of total energy. Construction also accounts for 39% of wood consumed in the U S, while 25% of solid waste volume is construction and demolition (C &D) debris. The SELC will incorporate a variety of materials and techniques that will address these and other issues, while providing a model of environmentally considered design for Bay Area residents and builders. Environmental considerations include energy use in construction and operations, selection of materials, waste minimization, and indoor air quality. We have developed five major environmental goals for this project: (1) Minimize energy use in construction and operations; (2) Employ material sources that are renewable, salvaged, recycled, and/or recyclable; (3) Increase building lifespan with durable materials and designs that permit flexibility and modification with minimal demolition; (4) Reduce and strive to eliminate construction debris; and (5) Avoid products that create toxic pollutants and make a healthy indoor environment.

  9. NASA, Building Tomorrow's Future

    Science.gov (United States)

    Mango, Edward

    2011-01-01

    We, as NASA, continue to Dare Mighty Things. Here we are in October. In my country, the United States of America, we celebrate the anniversary of Christopher Columbus's arrival in the Americas, which occurred on October 12, 1492. His story, although happening over 500 years ago, is still very valid today. It is a part of the American spirit; part of the international human spirit. Columbus is famous for discovering the new world we now call America, but he probably never envisioned what great discoveries would be revealed many generations later. But in order for Columbus to begin his great adventure, he needed a business plan. Ho would he go about obtaining the funds and support necessary to build, supply, and man the ships required for his travels? He had a lot of obstacles and distractions. He needed a strong, internal drive to achieve his plans and recruit a willing crew of explorers also ready to risk their all for the unknown journey ahead. As Columbus set sail, he said "By prevailing over all obstacles and distractions, one may unfailingly arrive at his chosen goal or destination." Columbus may not have known he was on a journey for all human exploration. Recently, Charlie Bolden, the NASA Administrator, said, "Human exploration is and has always been about making life better for humans on Earth." Today, NASA and the U.S. human spaceflight program hold many of the same attributes as did Columbus and his contemporaries - a willing, can-do spirit. We are on the threshold of exciting new times in space exploration. Like Columbus, we need a business plan to take us into the future. We need to design the best ships and utilize the best designers, with their past knowledge and experience, to build those ships. We need funding and support from governments to achieve these goals of space exploration into the unknown. NASA does have that business plan, and it is an ambitious plan for human spaceflight and exploration. Today, we have a magnificent spaceflight

  10. Energy Efficiency Building Code for Commercial Buildings in Sri Lanka

    Energy Technology Data Exchange (ETDEWEB)

    Busch, John; Greenberg, Steve; Rubinstein, Francis; Denver, Andrea; Rawner, Esther; Franconi, Ellen; Huang, Joe; Neils, Danielle

    2000-09-30

    1.1.1 To encourage energy efficient design or retrofit of commercial buildings so that they may be constructed, operated, and maintained in a manner that reduces the use of energy without constraining the building function, the comfort, health, or the productivity of the occupants and with appropriate regard for economic considerations. 1.1.2 To provide criterion and minimum standards for energy efficiency in the design or retrofit of commercial buildings and provide methods for determining compliance with them. 1.1.3 To encourage energy efficient designs that exceed these criterion and minimum standards.

  11. BUILDING MATERIALS RECLAMATION PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    David C. Weggel; Shen-En Chen; Helene Hilger; Fabien Besnard; Tara Cavalline; Brett Tempest; Adam Alvey; Madeleine Grimmer; Rebecca Turner

    2010-08-31

    This report describes work conducted on the Building Materials Reclamation Program for the period of September 2008 to August 2010. The goals of the project included selecting materials from the local construction and demolition (C&D) waste stream and developing economically viable reprocessing, reuse or recycling schemes to divert them from landfill storage. Educational resources as well as conceptual designs and engineering feasibility demonstrations were provided for various aspects of the work. The project was divided into two distinct phases: Research and Engineering Feasibility and Dissemination. In the Research Phase, a literature review was initiated and data collection commenced, an advisory panel was organized, and research was conducted to evaluate high volume C&D materials for nontraditional use; five materials were selected for more detailed investigations. In the Engineering Feasibility and Dissemination Phase, a conceptual study for a regional (Mecklenburg and surrounding counties) collection and sorting facility was performed, an engineering feasibility project to demonstrate the viability of recycling or reuse schemes was created, the literature review was extended and completed, and pedagogical materials were developed. Over the two-year duration of the project, all of the tasks and subtasks outlined in the original project proposal have been completed. The Final Progress Report, which briefly describes actual project accomplishments versus the tasks/subtasks of the original project proposal, is included in Appendix A of this report. This report describes the scientific/technical aspects (hypotheses, research/testing, and findings) of six subprojects that investigated five common C&D materials. Table 1 summarizes the six subprojects, including the C&D material studied and the graduate student and the faculty advisor on each subproject.

  12. The 'Big Five'. Hypothesis generation: a multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: a post hoc analysis of the ARCHUS cluster-randomised controlled trial.

    Science.gov (United States)

    Connolly, Martin J; Broad, Joanna B; Boyd, Michal; Zhang, Tony Xian; Kerse, Ngaire; Foster, Susan; Lumley, Thomas; Whitehead, Noeline

    2016-05-01

    long-term care (LTC) residents have higher hospitalisation rates than non-LTC residents. Rapid decline may follow hospitalisations, hence the importance of preventing unnecessary hospitalisations. Literature describes diagnosis-specific interventions (for cardiac failure, ischaemic heart disease, chronic obstructive pulmonary disease, stroke, pneumonia-termed 'big five' diagnoses), impacting on hospitalisations of older community-dwellers, but few RCTs show reductions in acute admissions from LTC. LTC facilities with higher than expected hospitalisations were recruited for a cluster-randomised controlled trial (RCT) of facility-based complex, non-disease-specific, 9-month intervention comprising gerontology nurse specialist (GNS)-led staff education, facility benchmarking, GNS resident review and multidisciplinary discussion of residents selected using standard criteria. In this post hoc exploratory analysis, the outcome was acute hospitalisations for 'big five' diagnoses. Re-randomisation analyses were used for end points during months 1-14. For end points during months 4-14, proportional hazards models are adjusted for within-facility clustering. we recruited 36 facilities with 1,998 residents (1,408 female; mean age 82.9 years); 1,924 were alive at 3 months. The intervention did not impact overall rates of acute hospitalisations or mortality (previously published), but resulted in fewer 'big five' admissions (RR = 0.73, 95% CI = 0.54-0.99; P = 0.043) with no significant difference in the rate of other acute admissions. When considering events occurring after 3 months (only), the intervention group were 34.7% (HR = 0.65; 95% CI = 0.49-0.88; P = 0.005) less likely to have a 'big five' acute admission than controls, with no differences in likelihood of acute admissions for other diagnoses (P = 0.96). this generic intervention may reduce admissions for common conditions which the literature shows are impacted by disease-specific admission reduction strategies.

  13. Better Buildings Neighborhood Program: BetterBuildings Lowell Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Heslin, Thomas

    2014-01-31

    The City of Lowell set four goals at the beginning of the Better Buildings Neighborhood Program: 1. Improve the Downtown Historic Park District’s Carbon Footprint 2. Develop a sustainable and replicable model for energy efficiency in historic buildings 3. Create and retain jobs 4. Promote multi-stakeholder partnerships The City of Lowell, MA was awarded $5 million in May 2010 to conduct energy efficiency retrofits within the downtown National Historical Park (NHP). The City’s target was to complete retrofits in 200,000 square feet of commercial space and create 280 jobs, while adhering to the strict historical preservation regulations that govern the NHP. The development of a model for energy efficiency in historic buildings was successfully accomplished. BetterBuildings Lowell’s success in energy efficiency in historic buildings was due to the simplicity of the program. We relied strongly on the replacement of antiquated HVAC systems and air sealing and a handful of talented energy auditors and contractors. BetterBuildings Lowell was unique for the Better Buildings Neighborhood Program because it was the only program that focused solely on commercial properties. BetterBuildings Lowell did target multi-family properties, which were reported as commercial, but the majority of the building types and uses were commercial. Property types targeted were restaurants, office buildings, museums, sections of larger buildings, mixed use buildings, and multifamily buildings. This unique fabric of building type and use allows for a deeper understanding to how different properties use energy. Because of the National Historical Park designation of downtown Lowell, being able to implement energy efficiency projects within a highly regulated historical district also provided valuable research and precedent proving energy efficiency projects can be successfully completed in historical districts and historical buildings. Our program was very successful in working with the local

  14. Sick building syndrome in relation to building dampness in multi-family residential buildings in Stockholm.

    Science.gov (United States)

    Engvall, K; Norrby, C; Norbäck, D

    2001-05-01

    The aim was to study relationships between symptoms compatible with sick building syndrome (SBS) on one hand, and different indicators of building dampness in Swedish multi-family buildings on the other. In Stockholm, 609 multi-family buildings with 14,235 dwellings were identified, and selected by stratified random sampling. The response rate was 77%. Information on weekly symptoms, age, gender, population density in the apartment, water leakage during the past 5 years, mouldy odour, condensation on windows, and high air humidity in the bathroom was assessed by a postal questionnaire. In addition, independent information on building characteristics was gathered from the building owners, and the central building register in Stockholm. Multiple logistic regression analysis was applied, and adjusted odds ratios (OR) were calculated, adjusted for age and gender, population density, and selected building characteristics. Condensation on windows, high air humidity in the bathroom, mouldy odour, and water leakage was reported from 9.0%, 12.4%, 7.7% and 12.7% of the dwellings, respectively. In total 28.5% reported at least one sign of dampness. All indicators of dampness were related to an increase of all types of symptoms, significant even when adjusted for age, gender, population density, type of ventilation system, and ownership of the building. A combination of mouldy odour and signs of high air humidity was related to an increased occurrence of all types of symptoms (OR = 3.7-6.0). Similar findings were observed for a combination of mouldy odour and structural building dampness (water leakage) (OR = 2.9 5.2). In addition, a dose-response relationship between symptoms and number of signs of dampness was observed. In dwellings with all four dampness indicators, OR was 6.5, 7.1, 19.9, 5.8, 6.1, 9.4, 15.0 for ocular, nasal, throat, dermal symptoms, cough, headache and tiredness, respectively. Signs of high air humidity, as well as of structural building dampness, are

  15. Consumer Central Energy Flexibility in Office Buildings

    DEFF Research Database (Denmark)

    Ma, Zheng; Billanes, Joy Dalmacio; Jørgensen, Bo Nørregaard

    2017-01-01

    Energy flexibility in buildings will play an important role in the smart energy system. Office buildings have more potentials to provide energy flexibility to the grid compared to other types of buildings, due to the existing building management, control systems and large energy consumption....... Consumers in office buildings (building owners/managers and occupants) take a main role for adopting and engaging in building energy flexibility. In this paper provides a systematic review of consumer central energy flexibility in office buildings with the discussion of social, technical and business...... can boost energy flexibility in the office buildings....

  16. Energy efficient and healthy buildings

    Energy Technology Data Exchange (ETDEWEB)

    Gullberg, Monica [AaF Process (Sweden); Oefverholm, Egil [Swedish Energy Agency, Eskilstuna (Sweden); Bengtsson, Magnus; Tolstoy, Nikolaj [National Board of Housing, Building and Planning (Sweden)

    2007-07-01

    Indoor environment has become an important subject matter in Scandinavia since increasingly many buildings demonstrate poor indoor air quality, problems with mould and other sick building syndromes. There are worries that the malignity is derived from tighter constructions and more sparse ventilation since problems have been escalating contemporary to better energy efficiency in the building stock. Based on this possible linkage, Sweden has decided to include also indoor environment aspects in the implementation of the directive on energy declaration of buildings. By the same token, a co-operation between the Swedish Energy Agency and the National Board of Housing, Building and Planning is underway where more than 100 schools are investigated regarding their energy usage patterns as well as their indoor environment status. Results from this inventory will be elaborated in this paper. The hypothesis for the investigation is that it is quite possible to demonstrate energy efficient and healthy buildings, and therefore results will give no significant statistical linkage between poor indoor quality and low specific energy use. Preliminary findings underpin this assumption. The paper will discuss the factors and their statistical interaction in more detail, and a discussion will be held on what other reasons there can be behind the sick buildings.

  17. Material Efficiency of Building Construction

    Directory of Open Access Journals (Sweden)

    Antti Ruuska

    2014-07-01

    Full Text Available Better construction and use of buildings in the European Union would influence 42% of final energy consumption, about 35% of our greenhouse gas emissions and more than 50% of all extracted materials. It could also help to save up to 30% of water consumption. This paper outlines and draws conclusions about different aspects of the material efficiency of buildings and assesses the significance of different building materials on the material efficiency. The research uses an extensive literature study and a case-study in order to assess: should the depletion of materials be ignored in the environmental or sustainability assessment of buildings, are the related effects on land use, energy use and/or harmful emissions significant, should related indicators (such as GHGs be used to indicate the material efficiency of buildings, and what is the significance of scarce materials, compared to the use of other building materials. This research suggests that the material efficiency should focus on the significant global impacts of material efficiency; not on the individual factors of it. At present global warming and greenhouse gas emissions are among the biggest global problems on which material efficiency has a direct impact on. Therefore, this paper suggests that greenhouse gas emissions could be used as an indicator for material efficiency in building.

  18. Green buildings need good ergonomics.

    Science.gov (United States)

    Hedge, A; Dorsey, J A

    2013-01-01

    A retrospective post-occupancy evaluation survey of 44 occupants in two Leadership in Energy and Environmental Design (LEED) Platinum buildings on a US college campus is reported. The Internet survey covered a range of indoor environment and ergonomics issues. Results show that working in these buildings were a generally positive experience for their health, performance and satisfaction. However, in one building there were persistent issues of variability in air temperature, air freshness, air quality and noise that affected the perceived health and performance of the occupants. Although the buildings were energy-efficient and sustainable structures, ergonomics design issues were identified. Implications for the role of ergonomics in green buildings and in the US LEED rating system are discussed. This survey identified a number of ergonomics design issues present in the LEED Platinum energy-efficient and sustainable buildings that were studied. These results highlight the importance of integrating ergonomics design into green buildings as a component in the US LEED rating system.

  19. Building 774: open for business

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    In July 2012, the demolition of Building 936 on the Prévessin site marked the start of the Building 774 project. On 23 February, less than three years later, the new 3900 m2 building was handed over to the BE department.   The brand new Building 774. (Credits: Francesco Soppelsa) Located near to the CERN Control Centre, Building 774 contains offices, laboratories and meeting rooms, as well as a huge public area consisting of a 104-seat auditorium, a changing room/shower area in the basement and a pleasant cafeteria open from 8 a.m. to 5 p.m., offering a wide range of refreshments including hot meals at lunchtime. “There were a few twists and turns during the construction of this building, but it all turned out well in the end!" says Michael Poehler, a member of the GS-SE group and the technical coordinator of the project. (Credits: Francesco Soppelsa) The 120 occupants of the building have just moved into their brand new home, bringing all the members of the...

  20. Digital Handover of Data from Building Projects to Building Operation

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2006-01-01

    and construction and on the other side in building opera-tion and facilities management. In Denmark the government has launched a development program called Digital Construction and one of the projects concerns specifying require-ments for building clients in relation to digital handover of data from construction......The development of computer based facilities management has not developed as rapid as expected by most professionals, mainly due to lack of interoperability between IT sys-tems. This is particularly a problem with the transfer of data between IT systems used on the one side in building design...... pro-jects to building operation. This project started in 2004 with research and analyses fol-lowed by development of a proposal for client requirements and in 2005 a first test on a real construction project has been carried out. After revision of the requirements a second test will be started early...

  1. Buildings-to-Grid Technical Opportunities: From the Buildings Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Piette, Mary Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-03-28

    This paper describes technologies and systems needed to transform buildings from the current state of siloed resources into transparent, reliable resources that participate in and benefit from an integrated "transactive energy" system.

  2. Energy efficiency buildings program, FY 1980

    Energy Technology Data Exchange (ETDEWEB)

    1981-05-01

    A separate abstract was prepared on research progress in each group at LBL in the energy efficient buildings program. Two separate abstracts were prepared for the Windows and Lighting Program. Abstracts prepared on other programs are: Energy Performance of Buildings; Building Ventilation and Indoor Air Quality Program; DOE-21 Building Energy Analysis; and Building Energy Data Compilation, Analysis, and Demonstration. (MCW)

  3. ImBuild: Impact of building energy efficiency programs

    Energy Technology Data Exchange (ETDEWEB)

    Scott, M.J.; Hostick, D.J.; Belzer, D.B.

    1998-04-01

    As part of measuring the impact of government programs on improving the energy efficiency of the Nation`s building stock, the Department of Energy Office of Building Technology, State and Community Programs (BTS) is interested in assessing the economic impacts of its portfolio of programs, specifically the potential impact on national employment and income. The special-purpose version of the IMPLAN model used in this study is called ImBuild. In comparison with simple economic multiplier approaches, such as Department of Commerce RIMS 2 system, ImBuild allows for more complete and automated analysis of the economic impacts of energy efficiency investments in buildings. ImBuild is also easier to use than existing macroeconomic simulation models. The authors conducted an analysis of three sample BTS energy programs: the residential generator-absorber heat exchange gas heat pump (GAX heat pump), the low power sulfur lamp (LPSL) in residential and commercial applications, and the Building America program. The GAX heat pump would address the market for the high-efficiency residential combined heating and cooling systems. The LPSL would replace some highly efficient fluorescent commercial lighting. Building America seeks to improve the energy efficiency of new factory-built, modular, manufactured, and small-volume, site-built homes through use of systems engineering concepts and early incorporation of new products and processes, and by increasing the demand for more energy-efficient homes. The authors analyze a scenario for market penetration of each of these technologies devised for BTS programs reported in the BTS GPRA Metrics Estimates, FY99 Budget Request, December 19, 1997. 46 figs., 4 tabs.

  4. Straw insulated buildings. Nature building materials; Strohgedaemmte Gebaeude. Naturbaustoffe

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-01

    Straw is one of the major agricultural by-products and is mainly used as litter in animal husbandry and to compensate the balance of humus. A relatively recent development is the use of straw bales for the construction of buildings. The brochure under consideration documents the technical development of straw construction in Germany. Possibilities of the use of straw in single family homes up to commercial buildings are described.

  5. Building and Testing with Gradle

    CERN Document Server

    Berglund, Tim

    2011-01-01

    Build and test software written in Java and many other languages with Gradle, the open source project automation tool that's getting a lot of attention. This concise introduction provides numerous code examples to help you explore Gradle, both as a build tool and as a complete solution for automating the compilation, test, and release process of simple and enterprise-level applications. Discover how Gradle improves on the best ideas of Ant, Maven, and other build tools, with standards for developers who want them and lots of flexibility for those who prefer less structure. Use Gradle with Gr

  6. Build and Execute Environment

    Energy Technology Data Exchange (ETDEWEB)

    2017-04-21

    At exascale, the challenge becomes to develop applications that run at scale and use exascale platforms reliably, efficiently, and flexibly. Workflows become much more complex because they must seamlessly integrate simulation and data analytics. They must include down-sampling, post-processing, feature extraction, and visualization. Power and data transfer limitations require these analysis tasks to be run in-situ or in-transit. We expect successful workflows will comprise multiple linked simulations along with tens of analysis routines. Users will have limited development time at scale and, therefore, must have rich tools to develop, debug, test, and deploy applications. At this scale, successful workflows will compose linked computations from an assortment of reliable, well-defined computation elements, ones that can come and go as required, based on the needs of the workflow over time. We propose a novel framework that utilizes both virtual machines (VMs) and software containers to create a workflow system that establishes a uniform build and execution environment (BEE) beyond the capabilities of current systems. In this environment, applications will run reliably and repeatably across heterogeneous hardware and software. Containers, both commercial (Docker and Rocket) and open-source (LXC and LXD), define a runtime that isolates all software dependencies from the machine operating system. Workflows may contain multiple containers that run different operating systems, different software, and even different versions of the same software. We will run containers in open-source virtual machines (KVM) and emulators (QEMU) so that workflows run on any machine entirely in user-space. On this platform of containers and virtual machines, we will deliver workflow software that provides services, including repeatable execution, provenance, checkpointing, and future proofing. We will capture provenance about how containers were launched and how they interact to annotate

  7. Prostate cancer incidence and disease-specific survival of men with initial prostate-specific antigen less than 3.0 ng/ml who are participating in ERSPC Rotterdam.

    Science.gov (United States)

    Bul, Meelan; van Leeuwen, Pim J; Zhu, Xiaoye; Schröder, Fritz H; Roobol, Monique J

    2011-04-01

    The European Randomised Study of Screening for Prostate Cancer (ERSPC) applies a prostate-specific antigen (PSA) cut-off value ≥3.0 ng/ml as an indication for lateralised sextant biopsy. To analyse the incidence and disease-specific mortality for prostate cancer (PCa) in men with an initial PSA first screening round. A PSA 20 ng/ml, positive lymph nodes, or metastases at diagnosis) was detected in 66 of 733 screen-detected PCa cases (9.0%) and 72 of 182 interval-detected PCa cases (39.6%). Twenty-three PCa deaths occurred in the total population (0.15%), with an increasing risk of PCa mortality in men with higher initial PSA values. The risk of PCa, aggressive PCa and PCa mortality in a screening population with initial PSA <3.0 ng/ml increases significantly with higher initial PSA levels. These results contribute to the risk stratification and individual management of men in PSA-based screening programmes. Copyright © 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  8. International development of four EORTC disease-specific quality of life questionnaires for patients with Hodgkin lymphoma, high- and low-grade non-Hodgkin lymphoma and chronic lymphocytic leukaemia.

    Science.gov (United States)

    van de Poll-Franse, Lonneke; Oerlemans, Simone; Bredart, Anne; Kyriakou, Charalampia; Sztankay, Monika; Pallua, Stephan; Daniëls, Laurien; Creutzberg, Carien L; Cocks, Kim; Malak, Sandra; Caocci, Giovanni; Molica, Stefano; Chie, Weichu; Efficace, Fabio

    2017-11-10

    This paper describes the international, cross-cultural development of four disease-specific EORTC QoL questionnaires, to supplement the EORTC QLQ-C30, for patients with Hodgkin lymphoma (HL), high- or low-grade non-Hodgkin lymphoma (HG/LG-NHL), and CLL. Questionnaire development was conducted according to guidelines from the EORTC Quality of Life Group. Phase I comprised generation of QoL issues relevant to patients. Phase II included operationalization and assessment of item relevance. In phase III, items were pretested in a cross-cultural sample. In Phase I, 75 issues were identified through focus groups and systematic literature searches. Interviews with 80 health-care professionals and 245 patients resulted in a provisional module of 38 items (phase II) representing items relevant for all or at least one of the four malignancies. In Phase III, this was tested in 337 patients from five European countries and resulted in a questionnaire with 27 items for HL (EORTC QLQ-HL27), 29 items for HG-NHL (EORTC QLQ-NHL-HG29), 20 items for LG-NHL (EORTC QLQ-NHL-LG20) and 17 items for CLL (EORTC QLQ-CLL17). This study provides four new EORTC modules for use in clinical research and routine practice in conjunction with the EORTC QLQ-C30 for assessing QoL in patients with lymphoma and CLL.

  9. Guidelines on Building Regulations 2008

    DEFF Research Database (Denmark)

    Thse guidelines clarify and intepret the provisions of the Building Regulations of 2008 (BR08). The Guidelines, which match BR08 in terms of organisation into Parts, are accompanied by the full text of the regulations and the explanatory notes issued by the Danish Enterprise and Construction...... Authority. The Guidelines refer the reader to sources such as relevant standards, instructions and other background material which provides more detailed information. The Guidelines cover the same ground as BR08, including building control regulations, layout, fitting out, structures, fire safety, indoor...... climate, energy consumotion and services. The Guidelines are aimed at all professionals involved in building projects, particularly building design consultants, contractors and municipal application officers....

  10. Armstrong's Building 703 in Palmdale

    Data.gov (United States)

    Federal Laboratory Consortium — NASA Armstrong Flight Research Center's (AFRC) Building 703 is located in Palmdale, Calif., 70 miles northeast of downtown Los Angeles. NASA has leased the facility,...

  11. LCG/AA build infrastructure

    CERN Document Server

    Hodgkins, Alex Liam; Hegner, Benedikt

    2012-01-01

    The Software Process & Infrastructure (SPI) project provides a build infrastructure for regular integration testing and release of the LCG Applications Area software stack. In the past, regular builds have been provided using a system which has been constantly growing to include more features like server-client communication, long-term build history and a summary web interface using present-day web technologies. However, the ad-hoc style of software development resulted in a setup that is hard to monitor, inflexible and difficult to expand. The new version of the infrastructure is based on the Django Python framework, which allows for a structured and modular design, facilitating later additions. Transparency in the workflows and ease of monitoring has been one of the priorities in the design. Formerly missing functionality like on-demand builds or release triggering will support the transition to a more agile development process.

  12. Building the Encyclopedia of Life

    Science.gov (United States)

    Mangiafico, P. A.; Patterson, D. J.

    2010-04-01

    The Encyclopedia of Life (EOL) is a collaborative project that indexes information about species, and makes it freely accessible to anyone. In order to accomplish this, EOL is building collaborative tools and infrastructure to unify the information.

  13. Build an Emergency Preparedness Kit

    Science.gov (United States)

    Build an emergency preparedness kit Disasters can occur quickly and without warning. Assemble a kit designed to help you cope with a variety of emergencies. Items for your kit: -First aid kit, essential ...

  14. Defining net zero energy buildings

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2013-01-01

    Full Text Available Worldwide increasing attention to energy consumption and associated environmental impacts thereof has resulted in a critical attitude towards energy usage of building. Increasing costs of energy and dependence on energy service providers add...

  15. Understanding Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Salom, Jaume; Widén, Joakim; Candanedo, José

    2011-01-01

    Although several alternative definitions exist, a Net-Zero Energy Building (Net ZEB) can be succinctly described as a grid-connected building that generates as much energy as it uses over a year. The “net-zero” balance is attained by applying energy conservation and efficiency measures...... and by incorporating renewable energy systems. While based on annual balances, a complete description of a Net ZEB requires examining the system at smaller time-scales. This assessment should address: (a) the relationship between power generation and building loads and (b) the resulting interaction with the power grid....... This paper presents and categorizes quantitative indicators suitable to describe both aspects of the building’s performance. These indicators, named LMGI - Load Matching and Grid Interaction indicators, are easily quantifiable and could complement the output variables of existing building simulation tools...

  16. 324 Building Baseline Radiological Characterization

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Reeder, J.C. Cooper

    2010-06-24

    This report documents the analysis of radiological data collected as part of the characterization study performed in 1998. The study was performed to create a baseline of the radiological conditions in the 324 Building.

  17. Women and Nation-Building

    National Research Council Canada - National Science Library

    Benard, Cheryl; Jones, Seth G; Oliker, Olga; Thurston, Cathryn Q; Stearns, Brooke K; Cordell, Kristen

    2008-01-01

    .... The RAND Corporation has contributed to the emerging knowledge base in this domain through a series of studies that have looked at nation-building enterprises led by the United States and others...

  18. Mechanisms of natural ventilation in livestock buildings

    DEFF Research Database (Denmark)

    Rong, Li; Bjerg, Bjarne Schmidt; Batzanas, Thomas

    2016-01-01

    Studies on the mechanisms of natural ventilation in livestock buildings are reviewed and influences on discharge and pressure coefficients are discussed. Compared to studies conducted on buildings for human occupation and industrial buildings which focus on thermal comfort, ventilation systems...

  19. Wood: a construction material for tall buildings

    Science.gov (United States)

    Wimmers, Guido

    2017-12-01

    Wood has great potential as a building material, because it is strong and lightweight, environmentally friendly and can be used in prefabricated buildings. However, only changes in building codes will make wood competitive with steel and concrete.

  20. Renovation work at Building 280

    CERN Multimedia

    EN Department

    2010-01-01

    Processing units and containers will be temporarily installed in front of Building 280 between 17 and 21 February 2010 while renovation work is carried out on electrical equipment. During this period, the Route FERMI, i.e. the area between Buildings 280 and 530, will be closed to traffic. You are requested to comply with the road signs in place. Thank you for your understanding. For further information, please call 160481. EN-EL Group

  1. A Guide to Building Commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, Michael C.

    2011-09-01

    Commissioning is the process of verifying that a building's heating, ventilation, and air conditioning (HVAC) and lighting systems perform correctly and efficiently. Without commissioning, system and equipment problems can result in higher than necessary utility bills and unexpected and costly equipment repairs. This report reviews the benefits of commissioning, why it is a requirement for Leadership in Energy and Environmental Design (LEED) certification, and why building codes are gradually adopting commissioning activities into code.

  2. A Novel Tetrathiafulvalene Building Block

    DEFF Research Database (Denmark)

    Jeppesen, Jan Oskar; Takimiya, Kazuo; Thorup, Niels

    1999-01-01

    Efficient synthesis of a novel tetrathiafulvalene building block. 2,3-bis(2-cyanoethylthio)-6,7-bis(thiocyanato-methyl)tetrathiafulv alene (7) useful for stepwise and asymmetrical bis-function-alization is reported.......Efficient synthesis of a novel tetrathiafulvalene building block. 2,3-bis(2-cyanoethylthio)-6,7-bis(thiocyanato-methyl)tetrathiafulv alene (7) useful for stepwise and asymmetrical bis-function-alization is reported....

  3. Building America House Simulation Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Engebrecht, Cheryn [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-09-01

    The House Simulation Protocol document was developed to track and manage progress toward Building America's multi-year, average whole-building energy reduction research goals for new construction and existing homes, using a consistent analytical reference point. This report summarizes the guidelines for developing and reporting these analytical results in a consistent and meaningful manner for all home energy uses using standard operating conditions.

  4. Building in a Market Economy

    DEFF Research Database (Denmark)

    Bonke, Sten; Levring, Peter

    This book offers a "state of the art" introduction to the "Danish way" of building. It presents a source of information and inspiration to the complex transitional process of rearranging the construction sectors in Central and Eastern European countries. The text gives a historical presentation o...... and functions of the main actors in the building process. During these passages and in a final section important future developments are highlighted, and characteristic research and development projects are presented....

  5. 3D modelling in building cadastre

    OpenAIRE

    Cedilnik, Rok

    2012-01-01

    Diploma thesis explained legislation and procedure of building registration, and also elaborate components for building registration in building cadastre. There are shown some ways of creating general 3D cadastre, and theories of establishment 3D building cadastre abroad. Some examples and reasons are shown why 3D cadastre building should be establish in Slovenia. With the help of software tool called AutoCAD is illustrated a way of creating 3D model building cadastre, there are also given so...

  6. Wynkoop Building Performance Measurement: Water

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, Kimberly M.; Kora, Angela R.

    2012-08-26

    This report is a summary of the water analysis performance for the Denver, Colorado Wynkoop Building. The Wynkoop Building (Figure 1) was built in 2006 as the Environmental Protection Agency (EPA) Region 8 Headquarters intended to house over 900 occupants in the 301,292 gross square feet (248,849 rentable square feet). The building was built on a brownfield in the Lower Downtown Historic District as part of an urban redevelopment effort. The building was designed and constructed through a public-private partnership with the sustainable design elements developed jointly by General Services Administration (GSA) and EPA. That partnership is still active with all parties still engaged to optimize building operations and use the building as a Learning Laboratory. The building design achieved U.S. Green Building Council Leadership in Energy and Environmental Design for New Construction (LEED-NC) Gold Certification in 2008 (Figure 2) and a 2008 EPA Energy Star Rating of 96 with design highlights that include: (1) Water use was designed to use 40% less than a typical design baseline. The design included low flow fixtures, waterless urinals and dual flush toilets; (2) Native and adaptive vegetation were selected to minimize the need for irrigation water for landscaping; and (3) Energy use intensity was modeled at 66.1 kBtus/gross square foot, which is 39% better than ASHRAE 90.1 1999. The Wynkoop Building water use (10 gallons/square foot) was measured at lower than industry average (15 gallons/square foot) and GSA goals (13 gallons/square foot), however, it was higher than building management expected it would be. The type of occupants and number of occupants can have a significant impact on fixture water use. The occupancy per floor varied significantly over the study time period, which added uncertainty to the data analysis. Investigation of the fixture use on the 2nd, 5th, and 7th floors identified potential for water use reduction if the flush direction of the dual

  7. Dust and the Sick Building Syndrome

    DEFF Research Database (Denmark)

    Gyntelberg, Finn; Suadicani, Poul; Wohlfahrt Nielsen, Jan

    1994-01-01

    Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome......Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome...

  8. Building envelope innovation: smart facades for non residential buildings

    Directory of Open Access Journals (Sweden)

    Marco Sala

    2011-11-01

    Full Text Available The research analyzes the evolution of smart façade systems in the area of design and industrial production, in order to investigate the technological, functional and qualitative standards of dynamic façade and evaluate the energy performance of the building envelope as a dynamic system that interacts between indoor and outdoor environment. The study focused on dynamic envelopes for office building analyzing the evolution of façade systems in terms of: building construction, innovative systems, smart materials, dynamic system. Aiming to improve building energy performances. The research, developed during the PhD thesis “Smart Envelope - dynamic and innovative technologies for energy saving” and the research “Abitare Mediterraneo”, aims to identify and define the energy performances of smart envelopes trough the analysis of the state of art, related to dynamic building envelope of double skin façade, and the development of a new dynamic façade system.

  9. Green commercial building insurance in Malaysia

    Science.gov (United States)

    Yang, Yu Xin Ou; Chew, Boon Cheong; Loo, Heoy Shin; Tan, Lay Hong

    2017-03-01

    Green building construction is growing tremendously globally even in Malaysia. Currently, there are approximate 636 buildings have registered and to be certified with Green Building Index. Among these buildings, 45 buildings have already fulfilled the requirements and fully certified. The other buildings still under provisional certification stage. Malaysia had adopted Green Building Index in 2009 to support a move to promote green building concept. Malaysia starts to move towards green building because Malaysian construction and building industry realizes that both energy consumed and waste produced are reduced without irreversible impacts to ecosystems. Consequently, insurance companies such as Fireman's Fund from America has started the green building insurance policies for their green building in the year of 2006, while Malaysia still remain the coverage for green buildings using conventional property insurance. There are lacks of efforts to be seen from insurance companies to propose green building insurance for these green buildings. There are a few factors which can take into consideration for insurance companies to start the very first green building insurance in Malaysia. Although there are challenges, some efficient strategies have been identified to overcome the problems. The methods used in this research topic is qualitative research. The results obtained shows that green commercial building insurance has a huge business opportunity in Malaysia because the number of green commercial buildings are increasing tremendously in Malaysia. It is a favor to implement green building insurance in Malaysia. Furthermore, insurance companies can consider to add in extra coverage in standard building policy to provide extra protection for non-certified green buildings which have the intention to rebuilt in green when damage happens. Generally, it is very important to introduce green commercial buildings insurance into Malaysia so that all of the green commercial

  10. Disease specific stress of tumor patients at the beginning of radiotherapy. Effect on psychosocial support requirement; Krankheitsspezifische Belastungen von Tumorpatienten zu Beginn einer Strahlentherapie. Auswirkungen auf den psychosozialen Betreuungsbedarf

    Energy Technology Data Exchange (ETDEWEB)

    Sehlen, S.; Hollenhorst, H.; Schymura, B.; Firsching, M.; Duehmke, E. [Ludwig-Maximilians-Univ., Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Aydemir, U. [Inst. fuer Biometrie und Epidemiologie, Klinikum Grosshadern, Ludwig-Maximilians-Univ., Muenchen (Germany); Herschbach, P. [Technische Univ. Muenchen (Germany). Inst. und Poliklinik fuer Psychosomatische Medizin, Psychotherapie und medizinische Psychologie

    2001-10-01

    Purpose: Radiotherapy brings a tumor patient into a special life situation in which different variables play a role of often unknown importance. The goal of this study was to investigate disease specific stress of tumor patients at the beginning of radiotherapy with established psychodiagnostic questionnaires and to evaluate the effect on psychosocial support requirement in order to reduce stress and to improve quality of life and compliance during radiotherapeutical treatment. Patients and Methods: 732 patients were screened, of whom 446 (60.9%) fulfilled the criteria for inclusion (refusals 21.0%, low Karnofsky performance status 6.6%, management problems 3.4%, language barriers 3.0%, cognitive restrictions 2.6%, death 2.5%). Disease specific aspects of stress in the questionnaire (Fragebogen zur Belastung von Krebspatienten, FBK), life situation (LS) and self-defined care requirements (BB) were self-rated by patients with different tumor types before radiotherapy. Medical and sociodemographic data were also documented. We investigated 446 patients (262 male, 184 female; median age 60.0 years) with different diagnoses. Results: Stress was observed mainly due to reduction of efficiency, anxiety and pain on the subscales. Women had a significant higher stress on subscales of pain (p=0.016) and anxiety (p=0.009), patients younger than 45 years in the subscale information (p=0.002) and patients older than 45 and younger than 60 years in the subscale anxiety (p=0.002) and the total score (p=0.003). Patients with mamma carcinoma had the highest stress. The maximum percentages of patients under high stress were found for the subscales of efficiency (43%) and anxiety (40%). The support requirement was characterized by the need of more medical information and dialogue with the doctor. We saw a significant correlation of high stress and high care requirement. Conclusions: Psychosocial support should be founded on psychosocial stress diagnostic and self-defined care

  11. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial.

    Science.gov (United States)

    Fietkau, Rainer; Lewitzki, Victor; Kuhnt, Thomas; Hölscher, Tobias; Hess, Clemens-F; Berger, Bernhard; Wiegel, Thomas; Rödel, Claus; Niewald, Marcus; Hermann, Robert M; Lubgan, Dorota

    2013-09-15

    In patients with head and neck and esophageal tumors, nutritional status may deteriorate during concurrent chemoradiotherapy (CRT). The aim of this study was to investigate the influence of enteral nutrition enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on body composition and nutritional and functional status. In a controlled, randomized, prospective, double-blind, multicenter study, 111 patients with head and neck and esophageal cancer undergoing concurrent CRT received either an enteral standard nutrition (control group) or disease-specific enteral nutrition Supportan®-containing EPA+DHA (experimental group) via percutaneous endoscopic gastrostomy. The primary endpoint was the change of body cell mass (BCM) following CRT at weeks 7 and 14 compared with the baseline value. Secondary endpoints were additional parameters of body composition, anthropometric parameters, and nutritional and functional status. The primary endpoint of the study, improvement in BCM, reached borderline statistical significance. Following CRT, patients with experimental nutrition lost only 0.82 ± 0.64 kg of BCM compared with 2.82 ± 0.77 kg in the control group (P = .055). The objectively measured nutritional parameters, such as body weight and fat-free mass, showed a tendency toward improvement, but the differences were not significant. The subjective parameters, in particular the Kondrup score (P = .0165) and the subjective global assessment score (P = .0065) after follow-up improved significantly in the experimental group, compared with the control group. Both enteral regimens were safe and well tolerated. Enteral nutrition with EPA and DHA may be advantageous in patients with head and neck or esophageal cancer by improving parameters of nutritional and functional status during CRT. © 2013 American Cancer Society.

  12. Building Footprints, Building footprints, building dimensions, and building data to coincide with Lyon County Appraiser's Office data. This data is NOT complete., Published in 2010, 1:1200 (1in=100ft) scale, City of Emporia / Lyon County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Building Footprints dataset current as of 2010. Building footprints, building dimensions, and building data to coincide with Lyon County Appraiser's Office data....

  13. Buildings and Health. Educational campaign for healthy buildings. Educational material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    In recent years health and comfort problems associated with the indoor climate have come to constitute a problem in Sweden. To come to grips with this a nationwide educational campaign on Buildings and Health is being run. It is directed to those involved in planning, project design, construction and management of buildings. The objective is to convey a body of knowledge to the many occupational and professional groups in the construction sector on how to avoid indoor climate problems in homes, schools, offices and other workplaces. The campaign is being run by the Swedish National Board of Housing and Planning and the Swedish Council for Building Research, in co-operation with various organizations and companies in the construction industry, and with municipalities and authorities. The knowledge which is being disseminated through the campaign is summarized in this compendium. figs., tabs.

  14. Modernising ATLAS Software Build Infrastructure

    CERN Document Server

    Ritsch, Elmar; The ATLAS collaboration

    2017-01-01

    In the last year ATLAS has radically updated its software development infrastructure hugely reducing the complexity of building releases and greatly improving build speed, flexibility and code testing. The first step in this transition was the adoption of CMake as the software build system over the older CMT. This required the development of an automated translation from the old system to the new, followed by extensive testing and improvements. This resulted in a far more standard build process that was married to the method of building ATLAS software as a series of $12$ separate projects from Subversion. We then proceeded with a migration of the code base from Subversion to Git. As the Subversion repository had been structured to manage each package more or less independently there was no simple mapping that could be used to manage the migration into Git. Instead a specialist set of scripts that captured the software changes across official software releases was developed. With some clean up of the repositor...

  15. Modernising ATLAS Software Build Infrastructure

    CERN Document Server

    Gaycken, Goetz; The ATLAS collaboration

    2017-01-01

    In the last year ATLAS has radically updated its software development infrastructure hugely reducing the complexity of building releases and greatly improving build speed, flexibility and code testing. The first step in this transition was the adoption of CMake as the software build system over the older CMT. This required the development of an automated translation from the old system to the new, followed by extensive testing and improvements. This resulted in a far more standard build process that was married to the method of building ATLAS software as a series of 12 separate projects from SVN. We then proceeded with a migration of its code base from SVN to git. As the SVN repository had been structured to manage each package more or less independently there was no simple mapping that could be used to manage the migration into git. Instead a specialist set of scripts that captured the software changes across official software releases was developed. With some clean up of the repository and the policy of onl...

  16. ATLAS Nightly Build System Upgrade

    Science.gov (United States)

    Dimitrov, G.; Obreshkov, E.; Simmons, B.; Undrus, A.; Atlas Collaboration

    2014-06-01

    The ATLAS Nightly Build System is a facility for automatic production of software releases. Being the major component of ATLAS software infrastructure, it supports more than 50 multi-platform branches of nightly releases and provides ample opportunities for testing new packages, for verifying patches to existing software, and for migrating to new platforms and compilers. The Nightly System testing framework runs several hundred integration tests of different granularity and purpose. The nightly releases are distributed and validated, and some are transformed into stable releases used for data processing worldwide. The first LHC long shutdown (2013-2015) activities will elicit increased load on the Nightly System as additional releases and builds are needed to exploit new programming techniques, languages, and profiling tools. This paper describes the plan of the ATLAS Nightly Build System Long Shutdown upgrade. It brings modern database and web technologies into the Nightly System, improves monitoring of nightly build results, and provides new tools for offline release shifters. We will also outline our long-term plans for distributed nightly releases builds and testing.

  17. Ecological modernization of sustainable buildings

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole; Gram-Hanssen, Kirsten

    2008-01-01

    This article will examine how the contemporary development of sustainable buildings has been influenced by the concept of ecological modernisation. Ecological modernisation is a policy concept describing how environmental considerations are increasingly being integrated into modern society......'s institutions through e.g. new types of co-operation and new applications of economic and market dynamics. The article is based on recent examples from politics and practice in the construction sector in Denmark, where sustainable buildings have gone through great changes - from being primarily isolated cases...... of governance, standardisation and visibility, the conclusion is that in many ways ecological modernisation has penetrated in Danish sustainable buildings and has contributed to a positive development. However, there are aspects of sustainable consumption that this development does not relate to, including...

  18. Building relationships for better maintenance.

    Science.gov (United States)

    Lee, Hackman Hon Yin; Scott, David

    2009-02-01

    Effective management of building maintenance is a vital ingredient in ensuring a high quality built environment for any building's occupiers. However, maintenance is not high on the list of priorities for most organisations. Communication between top management personnel looking at maintenance issues from a strategic standpoint and maintenance staff considering them at an operational level is often not as good as it should be. When planning maintenance activities maintenance personnel often draw too heavily on their technical experience and expertise without taking sufficient account of wider organisational objectives or consulting effectively with top management. Senior managers also regularly complain about lack of managerial input from maintenance departments. Such barriers contribute to communication difficulties between top management at a strategic level and maintenance personnel at an operational level. Identifying where the key differences lie in senior managers' and maintenance personnel's viewpoints on maintenance strategy can prove invaluable in achieving some convergence of opinions and optimising the efficiency of the overall building maintenance process.

  19. ATLAS Nightly Build System Upgrade

    CERN Document Server

    Dimitrov, G; The ATLAS collaboration; Simmons, B; Undrus, A

    2013-01-01

    The ATLAS Nightly Build System is a facility for automatic production of software releases. Being the major component of ATLAS software infrastructure, it supports more than 50 multi-platform branches of nightly releases and provides ample opportunities for testing new packages, for verifying patches to existing software, and for migrating to new platforms and compilers. The Nightly System testing framework runs several hundred integration tests of different granularity and purpose. The nightly releases are distributed and validated, and some are transformed into stable releases used for data processing worldwide. The first LHC long shutdown (2013-2015) activities will elicit increased load on the Nightly System as additional releases and builds are needed to exploit new programming techniques, languages, and profiling tools. This paper describes the plan of the ATLAS Nightly Build System Long Shutdown upgrade. It brings modern database and web technologies into the Nightly System, improves monitoring of nigh...

  20. ATLAS Nightly Build System Upgrade

    CERN Document Server

    Dimitrov, G; The ATLAS collaboration; Simmons, B; Undrus, A

    2014-01-01

    The ATLAS Nightly Build System is a facility for automatic production of software releases. Being the major component of ATLAS software infrastructure, it supports more than 50 multi-platform branches of nightly releases and provides ample opportunities for testing new packages, for verifying patches to existing software, and for migrating to new platforms and compilers. The Nightly System testing framework runs several hundred integration tests of different granularity and purpose. The nightly releases are distributed and validated, and some are transformed into stable releases used for data processing worldwide. The first LHC long shutdown (2013-2015) activities will elicit increased load on the Nightly System as additional releases and builds are needed to exploit new programming techniques, languages, and profiling tools. This paper describes the plan of the ATLAS Nightly Build System Long Shutdown upgrade. It brings modern database and web technologies into the Nightly System, improves monitoring of nigh...

  1. Recent changes in the Building Topology Ontology

    DEFF Research Database (Denmark)

    Rasmussen, Mads Holten; Pauwels, Pieter; Lefrancois, Maxime

    The Building Topology Ontology (BOT) was in early 2017 suggested to the W3C community group for Linked Building Data as a simple ontology covering the core concepts of a building. Since it was first announced it has been extended to cover a building site, elements hosted by other elements, zones...

  2. DNA and microfluidics: Building molecular electronics systems

    Energy Technology Data Exchange (ETDEWEB)

    Ye Yun [Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont., L5L 1C6 (Canada); Chen Lu [Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont., L5L 1C6 (Canada); Liu Xuezhu [Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont., L5L 1C6 (Canada); Krull, Ulrich J. [Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, Ont., L5L 1C6 (Canada)]. E-mail: ukrull@utm.utoronto.ca

    2006-05-24

    The development of molecular electronics using DNA molecules as the building blocks and using microfluidics to build nanowire arrays is reviewed. Applications of DNA conductivity to build sensors and nanowire arrays, and DNA conjugation with other nanostructures, offers an exciting opportunity to build extremely small analytical devices that are suitable for single-molecule detection and also target screening.

  3. Smoke control in buildings: An overview

    NARCIS (Netherlands)

    Twilt, L.; Oerle, N.J. van; Leur, P.H.E. van de

    1996-01-01

    Smoke poses a major hazard to people in a building involved in fire, being directly responsible for the majority of all deaths in building fires. Whereas the fire itself generally spreads through the building at a relatively slow rate, smoke takes only minutes to fill the building, if no actions are

  4. The energy performance of office buildings throughout their building process

    NARCIS (Netherlands)

    Entrop, Alexis Gerardus; Dewulf, Geert P.M.R.; Wamelink, J.W.F.; Geraedts, R.P.; Volker, L.

    2011-01-01

    Many innovative techniques and policy measures have been introduced to reduce energy consumption. Despite the high ambitions and societal pressures, the adoption rate of energy measures in office buildings is still low. Using adoption theories this paper provides a framework to analyse the adoption

  5. Sick building syndrome: in public buildings and workplaces

    National Research Council Canada - National Science Library

    Abdul-Wahab, Sabah A

    2011-01-01

    ... are health and pleasant to live in. The chapters of this book have elaborated in a clear style, yet scientifically solid, the causes, diagnostic tools, health impacts and mitigation approaches that may be applied to existing and planned buildings. I would like to congratulate the authors and the editor for this excellent effort. We at SQU are proud ...

  6. Synthetic building materials for transport buildings and structures

    Science.gov (United States)

    Gerasimova, Vera

    2017-10-01

    The most effective building materials account for the highest growth not only in construction of residential and public buildings, but also other capital projects including roadways, bridges, drainage, communications and other engineering projects. Advancement in the technology of more efficient and ecologically responsible insulation materials have been a priority for safety, minimal maintenance and longevity of finished construction projects. The practical use of modern building materials such as insulation, sound reduction and low energy consumption are a benefit in cost and application compared to the use of outdated heavier and labor-intensive materials. The most efficient way for maximizing insolation and sound proofing should be done during the design stages of the project according to existing codes and regulations that are required by Western Government. All methods and materials that are used need to be optimized in order to reach a high durability and low operational and maintenance cost exceeding more than 50 years of the life of the building, whether it is for public, industrial or residential use. Western construction techniques and technologies need to be applied and adapted by the Russian Federation to insure the most productive successful methods are being implemented. The issues of efficient insulation materials are outlined in this article.

  7. Building constructions: architecture and nature

    Directory of Open Access Journals (Sweden)

    Mayatskaya Irina

    2017-01-01

    Full Text Available The problem of optimization of building structures is considered in architectural bionic modeling on the bionic principle basis. It is possible to get a reliable and durable constructions by studying the structure and the laws of organization of natural objects. Modern architects have created unique buildings using the bionic approach. There are such properties as symmetry, asymmetry, self-similarity and fractality used in the modern architecture. Using the methods of fractal geometry in the design of architectural forms allows finding a variety of constructive solutions.

  8. Flash Builder building user interaction

    CERN Document Server

    Rocchi, Cesare

    2010-01-01

    Develop a working understanding of events and components, and containers and states so you can build and deploy RIAs in Flex. Work through a demo implementation of a login panel that employs feedback from the server side, to hone your understanding. Use the validators and the debugger to inspect your code execution. Building User Interaction is the second of five articles that will be compiled in the book, Data Visualization with Flash Builder: Designing RIA and AIR Applications with Remote Data Sources. Each full-color article illustrates specific aspects of Flash Builder data visualization

  9. Climate Responsive Buildings in China

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; Heiselberg, Per

    2006-01-01

    energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work within the framework of the Annex44 of the International Energy Agency (IEA......) and discusses its usefulness for Hong Kong and China. Special focus was put on the description of the different climates in China and a detailed analysis revealed its potential for energy conservation strategies. It could be shown that Natural Ventilation (NV) has the potential to increase thermal comfort up...

  10. Building Blocks of the Universe

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    This article presents possibilities to impart knowledge of and enthusiasm for particle physics to essentially all non-expert target audiences by the use of LEGO bricks and models of particle physics experiments built from these. Methods of using LEGO models, both as a passive exhibit and as part of interactive outreach events, are presented, along with a historical review of the “Build Your Own Particle Detector” programme and the corresponding idea of hosting competitions in building detector models in LEGO pieces as a perfect setting to grasp people’s attention, get them involved and ultimately convey knowledge in particle physics to them.

  11. SOLAR AIR CONDITIONING OF BUILDING

    Directory of Open Access Journals (Sweden)

    Debrayan Bravo Hidalgo

    2015-04-01

    Full Text Available Air Conditioning with renewable energy is a key issue in the region's energy policy. The high temperatures usually attributed to climate change and the increase of the standard of living in society continues increasing energy demand in order to establish the conditions for thermal comfort in buildings. Solar air conditioning, although it contains a mature technology, its level of market introduction and acceptance by designers of buildings is exhaustive. This paper discusses the feasibility of these projects, identifies non-technological type barriers that hinders such use and implementation of solar energy for air conditioning systems, and finally, it approaches some criteria and recommendations to overcome these obstacles.

  12. Building Autonomous Sensitive Artificial Listeners

    NARCIS (Netherlands)

    Schroeder, Marc; Bevacqua, Elisabetta; Cowie, Roddy; Eyben, Florian; Gunes, Hatice; Heylen, Dirk K.J.; ter Maat, Mark; McKeown, Gary; Pammi, Sathish; Pantic, Maja; Pelachaud, Catherine; Schuller, Björn; de Sevin, Etienne; Valstar, Michel; Wöllmer, Martin

    This paper describes a substantial effort to build a real-time interactive multimodal dialogue system with a focus on emotional and nonverbal interaction capabilities. The work is motivated by the aim to provide technology with competences in perceiving and producing the emotional and nonverbal

  13. Software Solution Builds Project Consensus.

    Science.gov (United States)

    Graue, David

    2003-01-01

    Describes the use of Autodesk Revit, a computer software system for design and documentation of buildings, in the planning of the University Center of Chicago, a large residence hall involving the cooperation of DePaul University, Columbia College, and Roosevelt University. (EV)

  14. GO FASTER: Building Morpheme Fluency

    Science.gov (United States)

    Fishley, Katelyn M.; Konrad, Moira; Hessler, Terri

    2017-01-01

    Vocabulary knowledge is an important foundation skill for reading across all subject areas. Because students with disabilities lag behind their peers in reading skills, there is a need for efficient and effective vocabulary interventions. Focusing on morpheme knowledge is one efficient approach to building vocabulary. This article describes an…

  15. Biocide Runoff from Building Facades

    DEFF Research Database (Denmark)

    Bollmann, Ulla E.; Fernández-Calviño, David; Brandt, Kristian K.

    2017-01-01

    Biocides are common additives in building materials. In-can and film preservatives in polymer-resin render and paint, as well as wood preservatives are used to protect facade materials from microbial spoilage. Biocides leach from the facade material with driving rain, leading to highly polluted...

  16. [The sick building syndrome (SBS)].

    Science.gov (United States)

    Ezratty, Véronique

    2003-10-11

    AN INCREASINGLY COMMON ENVIRONMENTAL HEALTH PROBLEM: Complaints related to indoor environment represent one of the most frequent problems that environmental health practitioners are confronted with. Hence the incidence of the Sick Building Syndrome (SBS) has been increasing since the Seventies. DIFFERING DEFINITIONS AND CLINICAL PRESENTATIONS: The WHO defines SBS as an excess of complaints and symptoms occurring in certain occupants of non-industrial buildings. The syndrome can only be evoked after elimination in the person concerned of a disease related to the building, the aetiological agent of which is identifiable. The symptoms described during SBS (headaches, concentration problems, asthenia, irritation of the skin or nasal mucosa, of the eyes and upper respiratory tract.) are non specific and frequently observed in the general population. AN UNKNOWN CASE, BUT NUMEROUS AETIOLOGICAL FACTORS SUSPECTED: There is no unanimously accepted definition nor physio-pathological theory to explain the occurrence of SBS in a particular building. Many favouring factors, including the type and rate of ventilation, volatile organic compounds, particles and humidity have been suspected. TECHNICAL, SOCIAL, AND MEDICAL MANAGEMENT IS REQUIRED: Although the symptoms are benign, they can be uncomfortable or even handicapping and prevent the functioning of workplaces. The SBS, the social and economical costs of which are high, requires multidisciplinary management.

  17. Durability of building joint sealants

    Science.gov (United States)

    Christopher C. White; Kar Tean Tan; Donald L. Hunston; R. Sam Williams

    2009-01-01

    Predicting the service life of building joint sealants exposed to service environments in less than real time has been a need of the sealant community for many decades. Despite extensive research efforts to design laboratory accelerated tests to duplicate the failure modes occurring in field exposures, little success has been achieved using conventional durability...

  18. Building Relations with Radiology Administrators

    Directory of Open Access Journals (Sweden)

    Megan Kalambo

    2017-06-01

    Full Text Available In some radiology departments, the lack of alignment between administrators and radiologists can pose significant challenges. This article describes how differences in background and priorities between administrators and radiologists can contribute to conflict and presents strategies on how to manage the conflict in a way that can leverage positive change. Strategies to build relations between radiologists and radiology administrators are described.

  19. Building Relations with Radiology Administrators.

    Science.gov (United States)

    Kalambo, Megan; Parikh, Jay R

    2017-06-07

    In some radiology departments, the lack of alignment between administrators and radiologists can pose significant challenges. This article describes how differences in background and priorities between administrators and radiologists can contribute to conflict and presents strategies on how to manage the conflict in a way that can leverage positive change. Strategies to build relations between radiologists and radiology administrators are described.

  20. Modern Institutional buildings in Florianopolis

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Fontoura Teixeira

    2015-12-01

    Full Text Available The article analyses institutional buildings of the modern period in Florianopolis, identifying its manifestations and impacts at the time of its production, between 1930 and 1980. These works are divided into three temporal cycles: the first defined by the insertion of modernist ideas and coexistence of different architectural languages; the second by the spread of modernism, influenced by other Brazilian experiences; and the third by vertical growth and technological sophistication, with the expansion of the use of reinforced concrete. The research spatially defines five city areas where the buildings are located. These configure urban centers, showing that public investment clearly conditioned the occupation. We also noted the presence of 32 buildings, 7 originated from federal institutions, 18 from the state power, 2 municipal and 5 from other categories. Its new typologies, spatial and form results inserted in the landscape and in the context of different times of the city currently mark regions and locations, promoting reading these buildings as remaining artifacts of a time when the city had a great ideal: modernize itself and adopt public spaces and services as the new image quality planned for the capital.

  1. Structural rehabilitation of old buildings

    CERN Document Server

    Guedes, João; Varum, Humberto

    2014-01-01

    The present book describes the different construction systems and structural materials and solutions within the main old buildings typologies, and it analyses the particularities of each of them, including mechanical properties, structural behaviour, typical damage patterns and collapse mechanisms. Common or pioneering intervention measures to repair and/or strengthen some of these structural elements are also reviewed.

  2. Team Building for Youth Sport

    Science.gov (United States)

    Bloom, Gordon A.; Loughead, Todd M.; Newin, Julie

    2008-01-01

    Participation in youth sport generally begins to decline after the age of 12. Among the reasons for this are personal aspects such as lack of desire, and social aspects including negative experiences with coaches. One way that coaches can improve the sporting environment is through group activities that promote team building. The purpose of this…

  3. Building Maintenance, Management, and Budgeting.

    Science.gov (United States)

    Pawsey, M. R.

    1982-01-01

    Australian methods and formulas for funding building maintenance and management are outlined and found to be haphazard. Discussed are: ultimate costs of deferred maintenance, major plant replacements, life cycle costing, types of maintenance programs (including full preventive maintenance), use of computer programs for planning, and organization…

  4. Dampness in Buildings and Health

    DEFF Research Database (Denmark)

    Clausen, Geo; Rode, Carsten; Bornehag, Carl-Gustaf

    1999-01-01

    . The main themes are:· Continued research in human perception of indoor air quality, especially by identification of the factors that may cause annoyance to the occupants. Such annoyances may be emissions from materials or biological activity, and is often linked to the dampness of buildings.· Studies...

  5. Urban heritage, building maintenance : Foundations

    NARCIS (Netherlands)

    Verhoef, L.G.W.

    1999-01-01

    What do we understand by the term 'foundations'? This general idea may embody the literal ' groundwork' that provides support for a building and may possibly include the entire structural works that serve to pre vent subsidence. Remarkably, in this definition the word 'groundwork' incorporates both

  6. Building contacts for the SKA

    Science.gov (United States)

    Bowler, Sue

    2016-06-01

    The Square Kilometre Array needs industrial expertise; SKA technology will, in turn, streamline big-data challenges for business and society. Or that's the idea: Sue Bowler reports on a day of networking designed to build industry-academia collaborations in the UK.

  7. Building brands without mass media.

    Science.gov (United States)

    Joachimsthaler, E; Aaker, D A

    1997-01-01

    Costs, market fragmentation, and new media channels that let customers bypass advertisements seem to be in league against the old ways of marketing. Relying on mass media campaigns to build strong brands may be a thing of the past. Several companies in Europe, making a virtue of necessity, have come up with alternative brand-building approaches and are blazing a trail in the post-mass-media age. In England, Nestlé's Buitoni brand grew through programs that taught the English how to cook Italian food. The Body Shop garnered loyalty with its support of environmental and social causes. Cadbury funded a theme park tied to its history in the chocolate business. Häagen-Dazs opened posh ice-cream parlors and got itself featured by name on the menus of fine restaurants. Hugo Boss and Swatch backed athletic or cultural events that became associated with their brands. The various campaigns shared characteristics that could serve as guidelines for any company hoping to build a successful brand: senior managers were closely involved with brand-building efforts; the companies recognized the importance of clarifying their core brand identity; and they made sure that all their efforts to gain visibility were tied to that core identity. Studying the methods of companies outside one's own industry and country can be instructive for managers. Pilot testing and the use of a single and continuous measure of brand equity also help managers get the most out of novel approaches in their ever more competitive world.

  8. Building TQM into nursing management.

    Science.gov (United States)

    Masters, M L; Masters, R J

    1993-01-01

    Total quality management (TQM) is a management philosophy that addresses problems currently faced by health care, specifically reducing costs while improving quality of services. As hospital administrators embrace this new management style, nurse executives and managers will be challenged to implement TQM. Building TQM into nursing management will improve quality and reduce costs while meeting the needs of health care customers.

  9. Daylight as a building material

    DEFF Research Database (Denmark)

    Thule Kristensen, Peter; Madsen, Merete

    2005-01-01

    The article draws on examples to chronologically trace the use of daylight as building material in architecture of the 20th and early 21st century. The essay covers works of Mies van der Rohe, Le Corbusier, Erik Bryggman, Rudolf Schwarz, Alvar Aalto, Aldo Rossi, Jørn Utzon, Daniel Libeskind, Pete...... Zumthor and Herzog & de Meuron...

  10. Build Your Own Space Station

    Science.gov (United States)

    Bolinger, Allison

    2016-01-01

    This presentation will be used to educate elementary students on the purposes and components of the International Space Station and then allow them to build their own space stations with household objects and then present details on their space stations to the rest of the group.

  11. Collapse simulation of building constructions

    Directory of Open Access Journals (Sweden)

    Nekrest'yanov Viktor Nikolaevich

    Full Text Available The physical reasons for building structures destruction are both the forces arising at stress-strain state of construction elements and external influences arising at emergency situations, as well as their moments, impulses and periodic impulses with the frequencies close to of fluctuations frequencies of construction elements. We shall call the mathematical calculation models for the parameters-reasons of destructions the basic models. The basic models of destruction of building structures elements allow not only providing necessary level of reliability and survivability of the elements and the construction as a whole already at the stage of their design, but also giving the chance, at their corresponding completion, to provide rational decisions on the general need of recovery works and their volume depending on destruction level. Especially important for rational design decisions development, which ensure the demanded constructional safety of building structures, is library creation of the basic mathematical models of standard processes of bearing elements destructions for standard construction designs for the purpose of the further forecast (assessment of the level and probabilities of standard destructions. Some basic mathematical models of destructions processes of the standard elements of building structures are presented in the present article. A model of accounting for construction defects and a model of obtaining requirements to probabilities of partial destructions of a construction are given. Both of these models are probabilistic.

  12. DYNAMIC ANAYSIS OF TALL BUILDINGS

    African Journals Online (AJOL)

    Dr Obe

    loads to those of identical frames modeled as shear frame s and considering the buildings as multi degree of freedom systems, based on numerical ... their possible sources from earthquakes, explosion, impact loads, moving loads, wind ..... L. Institute D. architecture et De Genie civil,. Sofia, vol xxvii No 3, pp 7-14, 1980. 4.

  13. Building server capabilities in China

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum

    2012-01-01

    The purpose of this paper is to further our understanding of multinational companies building server capabilities in China. The paper is based on the cases of two western companies with operations in China. The findings highlight a number of common patterns in the 1) managerial challenges related...

  14. Building a Culinary Arts Academy

    Science.gov (United States)

    Brown, Robert L.

    2005-01-01

    When Judy Karen Brown (the 2004 Alabama Family and Consumer Sciences Teacher of the Year) arrived at Bob Jones High School (BJHS) in Madison, Alabama, in the summer of 1999, she immediately identified a need to build both student and community interests in family and consumer sciences (FACS). She noticed the student and faculty interest in the…

  15. How to build a Caredroid

    NARCIS (Netherlands)

    Hoorn, J.F.

    2013-01-01

    There is a world to be gained with the establishment of a new industrial sector for robotic assistance in the care domain. How to Build a Caredroid is a signpost to its opportunities. Caredroids are humanoid systems that assist patients and caregivers in their duties and needs, simulating emotions,

  16. Computational Design for Sport Building

    NARCIS (Netherlands)

    Turrin, M.; Yang, D.; D'Aquilio, A.; Šileryte, R.; Sun, Y

    2016-01-01

    The design of sport buildings has great impact on top-sport as well as on recreational sport-activities. It implies challenging tasks in meeting the performance-requirements. This includes the control of factors like daylight/lighting, air flow, thermal conditions, just to name a few. Such factors

  17. Research projects and capacity building

    African Journals Online (AJOL)

    driniev

    2004-10-04

    Oct 4, 2004 ... and capacity to adapt to change (Senge, 1990; Barth and Bartenstein,. 1998; Davenport et al., 1998; Senge et al., ... ing catchment management through enhanced stakeholder participa- tion. The special emphasis on capacity .... Change and resistance to change. Building capacity involves change and ...

  18. Seismic Conceptual Design of Buildings

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 8. Seismic Conceptual Design of Buildings. K R Y Simha. Book Review Volume 12 Issue 8 August 2007 pp 82-84. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/012/08/0082-0084 ...

  19. Software Build and Delivery Systems

    Energy Technology Data Exchange (ETDEWEB)

    Robey, Robert W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-10

    This presentation deals with the hierarchy of software build and delivery systems. One of the goals is to maximize the success rate of new users and developers when first trying your software. First impressions are important. Early successes are important. This also reduces critical documentation costs. This is a presentation focused on computer science and goes into detail about code documentation.

  20. Recovery technologies for building materials

    Science.gov (United States)

    Karu, Veiko; Nurme, Martin; Valgma, Ingo

    2015-04-01

    Mining industry provides building materials for construction. Civil engineers have settled the quality parameters for construction materials. When we produce high quality building materials from carbonate rock (limestone, dolostone), then the estimated waste share is 25% to 30%, depending on crushing principles and rock quality. The challenge is to find suitable technology for waste recovery. During international mining waste related cooperation project MIN-NOVATION (www.min-novation.eu), partners mapped possibilities for waste recovery in mining industry and pointed out good examples and case studies. One example from Estonia showed that when we produce limestone aggregate, then we produce up to 30% waste material (fines with size 0-4mm). This waste material we can see as secondary raw material for building materials. Recovery technology for this fine grained material has been achieved with CDE separation plant. During the process the plant washes out minus 63 micron material from the limestone fines. This technology allows us to use 92% of all limestone reserves. By-product from 63 microns to 4 mm we can use as filler in concrete or as fine limestone aggregate for building or building materials. MIN-NOVATION project partners also established four pilot stations to study other mineral waste recovery technologies and solutions. Main aims on this research are to find the technology for recovery of mineral wastes and usage for new by-products from mineral mining waste. Before industrial production, testing period or case studies are needed. This research is part of the study of Sustainable and environmentally acceptable Oil shale mining No. 3.2.0501.11-0025 http://mi.ttu.ee/etp and the project B36 Extraction and processing of rock with selective methods - http://mi.ttu.ee/separation; http://mi.ttu.ee/miningwaste/

  1. Building Energy Management Open Source Software

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Saifur [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)

    2017-08-25

    Funded by the U.S. Department of Energy in November 2013, a Building Energy Management Open Source Software (BEMOSS) platform was engineered to improve sensing and control of equipment in small- and medium-sized commercial buildings. According to the Energy Information Administration (EIA), small- (5,000 square feet or smaller) and medium-sized (between 5,001 to 50,000 square feet) commercial buildings constitute about 95% of all commercial buildings in the U.S. These buildings typically do not have Building Automation Systems (BAS) to monitor and control building operation. While commercial BAS solutions exist, including those from Siemens, Honeywell, Johnsons Controls and many more, they are not cost effective in the context of small- and medium-sized commercial buildings, and typically work with specific controller products from the same company. BEMOSS targets small and medium-sized commercial buildings to address this gap.

  2. User Participation in the Building Process

    DEFF Research Database (Denmark)

    Christiansson, Per; Svidt, Kjeld; Sørensen, Kristian Birch

    2011-01-01

    Virtual Innovation in Construction (VIC) is a project aiming to develop an Information and Communication Technology (ICT) supported methodology VIC-MET, to involve building end-users in a creative innovation process together with building designers, and to capture and formulate end-user needs...... be established and conceptual building designs be illustrated. This is done in (2) 'Conceptual modelling space'. Here the VIC-MET proposes different tools and processes to build up a common understanding of end-user needs and values. In (3) 'Functional consolidation space', needs are linked to functional...... building systems (FBS), which are realized as component building systems (CBS), which will form parts in the total building solution. The formulated needs provide input to specific requirements in order to assure expected performance of the building components. The final virtual building model or part...

  3. Comparison of Building Energy Modeling Programs: Building Loads

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Dandan [Tsinghua Univ., Beijing (China); Hong, Tianzhen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yan, Da [Tsinghua Univ., Beijing (China); Wang, Chuang [Tsinghua Univ., Beijing (China)

    2012-06-01

    This technical report presented the methodologies, processes, and results of comparing three Building Energy Modeling Programs (BEMPs) for load calculations: EnergyPlus, DeST and DOE-2.1E. This joint effort, between Lawrence Berkeley National Laboratory, USA and Tsinghua University, China, was part of research projects under the US-China Clean Energy Research Center on Building Energy Efficiency (CERC-BEE). Energy Foundation, an industrial partner of CERC-BEE, was the co-sponsor of this study work. It is widely known that large discrepancies in simulation results can exist between different BEMPs. The result is a lack of confidence in building simulation amongst many users and stakeholders. In the fields of building energy code development and energy labeling programs where building simulation plays a key role, there are also confusing and misleading claims that some BEMPs are better than others. In order to address these problems, it is essential to identify and understand differences between widely-used BEMPs, and the impact of these differences on load simulation results, by detailed comparisons of these BEMPs from source code to results. The primary goal of this work was to research methods and processes that would allow a thorough scientific comparison of the BEMPs. The secondary goal was to provide a list of strengths and weaknesses for each BEMP, based on in-depth understandings of their modeling capabilities, mathematical algorithms, advantages and limitations. This is to guide the use of BEMPs in the design and retrofit of buildings, especially to support China’s building energy standard development and energy labeling program. The research findings could also serve as a good reference to improve the modeling capabilities and applications of the three BEMPs. The methodologies, processes, and analyses employed in the comparison work could also be used to compare other programs. The load calculation method of each program was analyzed and compared to

  4. Team Building e a enfermagem Team Building e enfermería Team Building and nursing

    Directory of Open Access Journals (Sweden)

    Filipa Homem

    2012-07-01

    Full Text Available Num ambiente de insatisfação crescente e de imprevisibilidade como é o da enfermagem, cada vez mais é fundamental motivar as equipas, conferindo-lhes competências pessoais, relacionais, comunicacionais e, acima de tudo, fomentar o trabalho em equipa e consequentemente a produtividade. O Team Building, surge assim como uma estratégia eficaz para obter resultados positivos. Por ser uma estratégia ainda pouco utilizada em Portugal, decidimos realizar este artigo teórico sobre o assunto e refletir sobre a sua pertinência e potencialidades nas equipas de enfermagem, tendo definido como objetivos: aprofundar conhecimentos sobre Team Building, contextualizar o Team Building no âmbito das teorias organizacionais, descrever diferentes modelos de Team Building e refletir sobre a utilidade do Team Building na qualidade da prestação de cuidados de enfermagem. Deste modo, foram pesquisados artigos na plataforma eletrónica de bases de dados EBSCO, assim como consultada literatura relacionada com a psicologia organizacional. Com a presente pesquisa conclui-se que esta estratégia de dinamização de equipas é útil no âmbito da enfermagem, podendo melhorar a comunicação e relações interpessoais, identificar pontos fortes e fracos das equipas, proporcionar maior satisfação no trabalho e, deste modo, aumentar a qualidade dos cuidados de saúde prestados.En un ambiente de creciente descontento y de imprevisibilidad como el de la enfermería, es cada vez más primordial motivar a los equipos, dándoles competencias personales, relacionales, y, sobre todo, fomentar el trabajo en equipo y consecuentemente la productividad. El Team Building surge así como una estrategia eficaz para lograr resultados positivos. Al ser una estrategia aún poco utilizada en Portugal, se decidió realizar este artículo teórico sobre el asunto y reflexionar sobre la pertinencia y el potencial de los equipos de enfermería, para lo que se definieron los objetivos

  5. buildings

    Directory of Open Access Journals (Sweden)

    Wang Hui

    2016-01-01

    Full Text Available In the formation of the blasting seismic wave transmission is a complex mechanical process. Blasting seismic wave in different geological structure formation of the interface, diffraction, reflection, projection as the incident Angle is different, all kinds of waveform transformation, formation of different types, different amplitude, frequency and phase of various wave superimposition of random composite wave. Blasting seismic wave propagation distance (horizontal distance and height difference, and the performance of the explosive, explosive charge, charge structure, priming method, congestion state what international airport, the plane and direction, topography and geological conditions will affect the blasting vibration effect. In engineering by empirical formula to estimate main parameters of blasting seismic wave and the structure of the empirical formula is the result of the use of theoretical analysis, by blasting of similar rate to determine the parameters in the formula is made up of many engineering measured data from statistical analysis, or directly by the measured parameters of the blasting seismic wave is given. In this paper, through various points were set in the prison line large speed is the most value, using the mathematical statistics regression analysis method, attenuation coefficient is obtained, and then back to the formula of single ring allows maximum dose safety distance calculated.

  6. STRUCTURAL DEFECTS OBSERVED AT STATE BUILDINGS

    Directory of Open Access Journals (Sweden)

    Hasan KAPLAN

    2007-02-01

    Full Text Available Although, state buildings are designed with higher building importance factors with respect to other buildings, they are damaged and collapsed in medium and large scale earthquakes occurred throughout the 14 year period starting from 1992 Erzincan Earthquake. Buildings, used for medical, educational, governmental and security purposes, have to be non-damaged and they should satisfy immediate occupancy after design earthquakes. In this study, structural deficiencies in 105 state buildings, of which seismic vulnerability assessment has been done in recent years, are investigated. Examples of different problems, which are not observed in other buildings mostly, are given.

  7. Hanford site post NPH building inspection plan

    Energy Technology Data Exchange (ETDEWEB)

    Wagenblast, G.R., Westinghouse Hanford

    1996-09-12

    This plan establishes consistent post-NPH building inspection procedures and defines a procedure for prioritization of buildings for inspection to ensure the safety of facilities prior to reentry. Qualification of systems for restart of operation is not included. This plan takes advantage, where possible, of existing national procedures for post-NPH inspection of buildings, of existing structural design and evaluation documentation of Hanford facilities, and current and proposed seismic instrumentation located throughout the Hanford site. A list of buildings, prioritized according to current building safety function and building vulnerability (without regard for or information about a damaging natural forces event) is provided.

  8. Application of BIM Technology in Prefabricated Buildings

    Science.gov (United States)

    Zhanglin, Guo; Si, Gao; Jun-e, Liu

    2017-08-01

    The development of fabricated buildings has become the main trend of the developm ent of modern construction industry in China. As the main tool of building information, BIM (b uilding information modeling) has greatly promoted the development of construction industry. Based on the review of the papers about the fabricated buildings and BIM technology in recent years, this paper analyzes the advantages of fabricated buildings and BIM technology, then exp lores the application of BIM technology in fabricated buildings. It aims to realize the rationaliz ation and scientification of project lifecycle management in fabricated construction project, and finally form a coherent information platform in the fabricated building.

  9. Collection building amongst heritage amateurs

    DEFF Research Database (Denmark)

    Roued-Cunliffe, Henriette

    2017-01-01

    Purpose The purpose of this paper is to gather an overview of different research fields that study collection building amongst heritage amateurs (e.g. amateur archaeologists, family and local historians, etc.). Design/methodology/approach First, the paper will define the term heritage amateur...... in a deeper understanding of collection building amongst heritage amateurs. Research limitations/implications The term heritage amateur is not widely used, and the identification and collection of material for the review rely on the definition and understanding of this term and the groups included under it....... Practical implications This review of existing literature will benefit researchers and practitioners in the fields of education, information science, museums, libraries and archival studies, as well as the multidisciplinary area of heritage studies. Social implications There is a growing institutional...

  10. Building bridges … and accelerators

    CERN Multimedia

    2009-01-01

    Lyn Evans, the LHC project leader, was awarded an honorary doctorate from the University of Geneva (UNIGE) to celebrate his role not just in building accelerators, but also in building bridges between nations. He was one of four notables honoured at the event on Friday 5 June, coinciding with the University’s 450th Anniversary. Lyn Evans arriving at the ceremony with Archbishop Desmond Tutu. "It was a big surprise when I found out I’d been nominated," recounts Evans, "but it was an even bigger surprise to find out with whom I’d been nominated". At the ceremony Evans was awarded the honorary doctorate along with three others: Archbishop Desmond Tutu, who was acclaimed for his fight against apartheid in South Africa, Mary Robinson, first woman president of Ireland and former United Nations’ high commissioner of human rights, and Pascal Lamy, Director-General of the World Trade Organization. The award ceremony, known as the �...

  11. BUILDING AN EFFECTIVE SALES FORCE

    Directory of Open Access Journals (Sweden)

    Ioana Olariu

    2016-07-01

    Full Text Available Building an effective sales force starts with selecting good salespeople, but good salespeople are very difficult to find. The reason for this is that most sales jobs are very demanding and require a great deal from the salesperson. There are many different types of sales jobs. Before it can hire salespeople, each company must do a careful job analysis to see what particular types of selling and other skills are necessary for each sales job. One task of the market planner is to establish clear objectives each year for the entire sales force, for each region, each sales office, and each salesperson. Sales jobs are different from in-house jobs in some significant ways. Nevertheless, each company must continually work on building and maintaining an effective sales force using the following steps: recruitment, selection, training, compensation and evaluation of each salesperson.

  12. Building treasures for rare disorders.

    Science.gov (United States)

    Baas, Melanie; Huisman, Sylvia; van Heukelingen, John; Koekkoek, Gerritjan; Laan, Henk-Willem; Hennekam, Raoul C

    2015-01-01

    The internet pre-eminently marks an era with unprecedented chances for patient care. Especially individuals with rare disorders and their families can benefit. Their handicap of low numbers vanishes and can become a strength, as small, motivated and well-organized international support groups allow easily fruitful collaborations with physicians and researchers. Jointly setting research agendas and building wikipedias has eventually led to building of multi-lingual databases of longitudinal data on physical and behavioural characteristics of individuals with several rare disorders which we call waihonapedias (waihona meaning treasure in Hawaiian). There are hurdles to take, like online security and reliability of diagnoses, but sharing experiences and true collaborations will allow better research and patient care for fewer costs to patients with rare disorders. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  13. Daylight utilisation in office buildings

    DEFF Research Database (Denmark)

    Christoffersen, Jens

    This Ph.D. thesis presents the qualitative and quantitative consequences of full-scale measurements on two daylighting systems, light shelf and Venetian blinds. The systems were investigated to assess their ability to increase daylight penetration and improve daylight distribution in the interior......, aiming at increased utili sation of daylight in order to supplement and replace artificial lighting. The visual quality is assessed only by subjective evalua tions of the luminous environment, luminance distributions in the interior and glare problems. This thesis does not pretend to answer or solve all...... the benefits and difficulties regarding use of daylight in office buildings, but it is hoped that the report will provide daylight conscious building design in forthcoming non-domestic buil dings....

  14. Build your own time machine

    CERN Document Server

    Clegg, Brian

    2012-01-01

    There is no physical law to prevent time travel nothing in physics to say it is impossible. So who is to say it can't be done? In Build Your Own Time Machine, acclaimed science writer Brian Clegg takes inspiration from his childhood heroes, Doctor Who and H. G. Wells, to explain the nature of time. How do we understand it and why measure it the way we do? How did the theories of one man change the way time was perceived by the world? Why wouldn't H. G. Wells's time machine have worked? And what would we need to do to make a real one? Build Your Own Time Machine explores the amazing possib

  15. Building a Sustainable Competitive Advantage

    Directory of Open Access Journals (Sweden)

    Mukesh Srivastava

    2013-03-01

    Full Text Available This paper analyzes cross-industrial best practices and future trends in the context of the contemporary resource based competitive advantage model of the firm. It identifies key managerial levers, tools and systems that can be used to build and sustain a Hi-Technology company’s core competences in order to facilitate a more innovative, collaborative 21st century corporate culture. A qualitative and quantitative assessment is made of how a firm’s leadership, human capital management, organizational culture, design and systems can all collectively merge to create a more dynamic and responsive organization which is far more adept at building unique resources and capabilities, which can then be leveraged to create new market opportunities with high competitive entry barriers.

  16. How to build a universe

    CERN Document Server

    Cox, Brian; Feachem, Alexandra

    2017-01-01

    The Infinite Monkey Cage, the legendary BBC Radio 4 programme, brings you this irreverent celebration of scientific marvels. Join us on a hectic leap through the grand and bizarre ideas conjured up by human imagination, from dark matter to consciousness via neutrinos and earthworms. Professor Brian Cox and Robin Ince muse on multifaceted subjects involved in building a universe, with pearls of wisdom from leading scientists and comedians peppered throughout. Covering billions of concepts and conundrums, they tackle everything from the Big Bang to parallel universes, fierce creatures to extraterrestrial life, brain science to artificial intelligence. How to Build a Universe is an illuminating and inspirational celebration of science - sometimes silly, sometimes astounding and very occasionally facetious.

  17. Super high-rise buildings

    Energy Technology Data Exchange (ETDEWEB)

    Maryon, J.C.

    1987-04-14

    This patent describes a super high-rise building for human occupation having at least 100 vertically spaced, human-occupiable stories comprising: a foundation; and a hollow vertical prism of reinforced concrete, mounted on the foundation and being at least 100 stories high, for transmitting to the foundation substantially all loads above at least the 75th floor of the building in a manner such that automatic lateral rigidity, stability, and strength are attained. The sides of the prism have apertures for such purposes as allowing human movement between the inside end and outside of the prism. The portion of substantially any horizontal circumference of the prism which is occupied by the apertures is less than about 25% of the horizontal circumference.

  18. U.S. Department of Energy Commercial Reference Building Models of the National Building Stock

    Energy Technology Data Exchange (ETDEWEB)

    Deru, M.; Field, K.; Studer, D.; Benne, K.; Griffith, B.; Torcellini, P.; Liu, B.; Halverson, M.; Winiarski, D.; Rosenberg, M.; Yazdanian, M.; Huang, J.; Crawley, D.

    2011-02-01

    The U.S. Department of Energy (DOE) Building Technologies Program has set the aggressive goal of producing marketable net-zero energy buildings by 2025. This goal will require collaboration between the DOE laboratories and the building industry. We developed standard or reference energy models for the most common commercial buildings to serve as starting points for energy efficiency research. These models represent fairly realistic buildings and typical construction practices. Fifteen commercial building types and one multifamily residential building were determined by consensus between DOE, the National Renewable Energy Laboratory, Pacific Northwest National Laboratory, and Lawrence Berkeley National Laboratory, and represent approximately two-thirds of the commercial building stock.

  19. BuildingPI: A future tool for building life cycle analysis

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, James; Morrissey, Elmer; Keane, Marcus; Bazjanac,Vladimir

    2004-03-29

    Traditionally building simulation models are used at the design phase of a building project. These models are used to optimize various design alternatives, reduce energy consumption and cost. Building performance assessment for the operational phase of a buildings life cycle is sporadic, typically working from historical metered data and focusing on bulk energy assessment. Building Management Systems (BMS) do not explicitly incorporate feedback to the design phase or account for any changes, which have been made to building layout or fabric during construction. This paper discusses a proposal to develop an Industry Foundation Classes (IFC) compliant data visualization tool Building Performance Indicator (BuildingPI) for performance metric and performance effectiveness ratio evaluation.

  20. Seismic strengthening of RC buildings

    OpenAIRE

    TSIONIS Georgios; APOSTOLSKA ROBERTA; TAUCER Fabio

    2014-01-01

    A literature review on the seismic strengthening of reinforced concrete buildings, using steel bracings, infills and shear walls, is presented. Extensive experimental testing and numerical analyses of elements and structures have demonstrated the feasibility and effectiveness of all three measures for the increase of global strength and stiffness. In certain cases, they provide additional energy dissipation and help reducing irregularities. The selection of the most appropriate technique i...