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Sample records for building disease-specific drug-protein

  1. Disease-specific classification using deconvoluted whole blood gene expression

    Science.gov (United States)

    Wang, Li; Oh, William K.; Zhu, Jun

    2016-01-01

    Blood-based biomarker assays have an advantage in being minimally invasive. Diagnostic and prognostic models built on peripheral blood gene expression have been reported for various types of disease. However, most of these studies focused on only one disease type, and failed to address whether the identified gene expression signature is disease-specific or more widely applicable across diseases. We conducted a meta-analysis of 46 whole blood gene expression datasets covering a wide range of diseases and physiological conditions. Our analysis uncovered a striking overlap of signature genes shared by multiple diseases, driven by an underlying common pattern of cell component change, specifically an increase in myeloid cells and decrease in lymphocytes. These observations reveal the necessity of building disease-specific classifiers that can distinguish different disease types as well as normal controls, and highlight the importance of cell component change in deriving blood gene expression based models. We developed a new strategy to develop blood-based disease-specific models by leveraging both cell component changes and cell molecular state changes, and demonstrate its superiority using independent datasets. PMID:27596246

  2. Personality changes in dementia: are they disease specific and universal?

    Science.gov (United States)

    Torrente, Fernando; Pose, Mariángeles; Gleichgerrcht, Ezequiel; Torralva, Teresa; López, Pablo; Cetkovich-Bakmas, Marcelo; Manes, Facundo

    2014-01-01

    Previous studies about personality changes in dementia suggest that they may be due to the disruption of the biological basis of personality traits, and hence, that they are disease specific and universal. However, evidence about its specificity is still limited and scarce regarding culturally diverse populations. Accordingly, our aim was to compare personality changes in Argentinean patients with Alzheimer disease, behavioral variant of frontotemporal dementia, and primary progressive aphasia. The closest living relatives of patients diagnosed with Alzheimer disease (n=19), behavioral variant of frontotemporal dementia (n=16), and primary progressive aphasia (n=15) were asked to complete 2 versions of the personality inventory NEO Personality Inventory-Revised, one for assessing patients' premorbid personality traits, and the other for assessing current traits. All groups showed changes in several domains and facets of the NEO Personality Inventory-Revised. Globally, the observed pattern of changes was fairly consistent with previous studies based on the same model of personality. Nevertheless, our results regarding disease-specificity were less conclusive. Even if there were some indicators of specific differences between groups, most traits varied similarly across the 3 groups, revealing a pattern of generalized changes in personality expression after illness onset. More studies are needed that help to distinguish real personality changes from other affective or cognitive symptoms that accompany dementia, as well as further data from culturally diverse populations.

  3. Generic and disease-specific measures of quality of life in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Bhattacharya, Sumangala; Vogel, A.; Hansen, M.L.;

    2010-01-01

    The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD)....

  4. Generic and disease-specific measures of quality of life in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Bhattacharya, Suvosree; Vogel, Asmus; Hansen, Marie-Louise H;

    2010-01-01

    The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD).......The aim of the study was to investigate the pattern of association of generic and disease-specific quality of life (QoL) scales with standard clinical outcome variables in Alzheimer's disease (AD)....

  5. Development of disease-specific quality indicators for danish chiropractic patients with low back pain

    DEFF Research Database (Denmark)

    Sorensen, Line P; Krog, Birgitte R; Kongsted, Alice;

    2011-01-01

    The purpose of this study is to develop disease-specific quality indicators for Danish chiropractic patients with low back pain (LBP) as an initial effort to include chiropractors in the Danish Health Care Quality Programme.......The purpose of this study is to develop disease-specific quality indicators for Danish chiropractic patients with low back pain (LBP) as an initial effort to include chiropractors in the Danish Health Care Quality Programme....

  6. Novel composite fiber structures to provide drug/protein delivery for medical implants and tissue regeneration.

    Science.gov (United States)

    Zilberman, Meital

    2007-01-01

    A novel class of bioresorbable composite (core/shell) fiber structures loaded with bioactive agents was developed and studied. These unique polymeric structures are designed to combine good mechanical properties with a desired controlled release profile, in order to serve as scaffolds for tissue regeneration applications and as basic elements of medical implants. These core/shell fiber structures were formed by "coating" core polymer fibers with drug/protein-containing poly(dl-lactic-co-glycolic acid) porous structures. The shell preparation ("coating") was performed by the freeze-drying of water-in-oil emulsions. Both water soluble and water insoluble agents can be incorporated in these structures and their activity is preserved, since the fiber fabrication requires neither high temperatures nor harsh solvents in the vicinity of the bioactive agents. Examples for release profiles of protein (horseradish peroxidase) and drug (paclitaxel) are presented. We have demonstrated that appropriate selection of the emulsion's parameters can yield a variety of new core/shell fiber structures with desirable drug/protein release behavior. This will lead to the engineering of new implants and scaffolds, and will advance the field of tissue regeneration and medical implants. PMID:16956799

  7. Gene expression profiling in autoimmune diseases: chronic inflammation or disease specific patterns?

    DEFF Research Database (Denmark)

    Bovin, Lone Frier; Brynskov, Jørn; Hegedüs, Laszlo;

    2007-01-01

    A central issue in autoimmune disease is whether the underlying inflammation is a repeated stereotypical process or whether disease specific gene expression is involved. To shed light on this, we analysed whether genes previously found to be differentially regulated in rheumatoid arthritis (RA...

  8. Death, tetanus, and aerobics: The evaluation of disease-specific health interventions

    OpenAIRE

    Dow, William H.; Holmes, Jessica; Philipson, Tomas; Sala-i-Martin, Xavier

    1995-01-01

    This paper provides a theoretical and empirical investigation of the positive complementarities between disease-specific policies introduced by competing risks of mortality. The incentive to invest in prevention against one cause of death depends positively on the level of survival from other causes. This means that a specific public health intervention has benefits other than the direct medical reduction in mortality: it affects the incentives to fight other diseases so the overall reduction...

  9. Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

    Science.gov (United States)

    Naschitz, Jochanan E; Rozenbaum, Michael; Fields, Madeline; Isseroff, Hillel; Enis, Sean; Babich, Jay P; Peck, Shannon; Peck, Elisabeth Rubin; Gaitini, Louis; Naschitz, Shaul; Sabo, Edmond; Rosner, Itzhak

    2005-01-01

    Aberrations of CVR (cardiovascular reactivity), an expression of autonomic function, lack specificity for a particular disorder. Recently, a CVR pattern particular to chronic fatigue syndrome has been observed. In the present study, we aimed to develop methodologies for assessing disease-specific CVR patterns. As a prototype, a population of 50 consecutive patients with FMF (familial Mediterranean fever) was studied and compared with control populations. A 10 min supine/30 min head-up tilt test with recording of the heart rate and blood pressure or the pulse transit time was performed. Five studies were conducted applying different methods. In each study, statistical analysis identified independent predictors of CVR in FMF. Based on regression coefficients of these predictors, a linear DS (discriminant score) was computed for every subject. Each study established an equation to assess CVR, calculate DS for FMF and determine the sensitivity and specificity of the DS cut-off. In each of the five studies, abnormal CVR was observed in FMF patients. The best accuracy (88% sensitivity and 90.1% specificity for FMF) was obtained by a method based on beat-to-beat heart rate and pulse transit time recordings. Data was processed by fractal and recurrence quantitative analysis with recordings in FMF patients compared with a mixed control population. Identification of disease-specific CVR patterns was possible with the methodologies described in the present study. In FMF, disease-specific CVR may be explained by the interplay between neuroendocrine loops specific to FMF with cardiovascular homoeostatic mechanisms. Recognition of disease-specific CVR patterns may advance the understanding of homoeostatic mechanisms and have implications in clinical practice. PMID:15330754

  10. Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing.

    Science.gov (United States)

    Pantazes, Robert J; Reifert, Jack; Bozekowski, Joel; Ibsen, Kelly N; Murray, Joseph A; Daugherty, Patrick S

    2016-01-01

    Disease-specific antibodies can serve as highly effective biomarkers but have been identified for only a relatively small number of autoimmune diseases. A method was developed to identify disease-specific binding motifs through integration of bacterial display peptide library screening, next-generation sequencing (NGS) and computational analysis. Antibody specificity repertoires were determined by identifying bound peptide library members for each specimen using cell sorting and performing NGS. A computational algorithm, termed Identifying Motifs Using Next- generation sequencing Experiments (IMUNE), was developed and applied to discover disease- and healthy control-specific motifs. IMUNE performs comprehensive pattern searches, identifies patterns statistically enriched in the disease or control groups and clusters the patterns to generate motifs. Using celiac disease sera as a discovery set, IMUNE identified a consensus motif (QPEQPF[PS]E) with high diagnostic sensitivity and specificity in a validation sera set, in addition to novel motifs. Peptide display and sequencing (Display-Seq) coupled with IMUNE analysis may thus be useful to characterize antibody repertoires and identify disease-specific antibody epitopes and biomarkers. PMID:27481573

  11. Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing

    Science.gov (United States)

    Pantazes, Robert J.; Reifert, Jack; Bozekowski, Joel; Ibsen, Kelly N.; Murray, Joseph A.; Daugherty, Patrick S.

    2016-01-01

    Disease-specific antibodies can serve as highly effective biomarkers but have been identified for only a relatively small number of autoimmune diseases. A method was developed to identify disease-specific binding motifs through integration of bacterial display peptide library screening, next-generation sequencing (NGS) and computational analysis. Antibody specificity repertoires were determined by identifying bound peptide library members for each specimen using cell sorting and performing NGS. A computational algorithm, termed Identifying Motifs Using Next- generation sequencing Experiments (IMUNE), was developed and applied to discover disease- and healthy control-specific motifs. IMUNE performs comprehensive pattern searches, identifies patterns statistically enriched in the disease or control groups and clusters the patterns to generate motifs. Using celiac disease sera as a discovery set, IMUNE identified a consensus motif (QPEQPF[PS]E) with high diagnostic sensitivity and specificity in a validation sera set, in addition to novel motifs. Peptide display and sequencing (Display-Seq) coupled with IMUNE analysis may thus be useful to characterize antibody repertoires and identify disease-specific antibody epitopes and biomarkers. PMID:27481573

  12. Nutritional status influences generic and disease-specific quality of life measures in haemodialysis patients

    Directory of Open Access Journals (Sweden)

    Ana Catarina Moreira

    2013-06-01

    Full Text Available Background: Poor nutritional status and worse health-related quality of life (QoL have been reported in haemodialysis (HD patients. The utilization of generic and disease specific QoL questionnaires in the same population may provide a better understanding of the significance of nutrition in QoL dimensions. Objective: To assess nutritional status by easy to use parameters and to evaluate the potential relationship with QoL measured by generic and disease specific questionnaires. Methods: Nutritional status was assessed by subjective global assessment adapted to renal patients (SGA, body mass index (BMI, nutritional intake and appetite. QoL was assessed by the generic EuroQoL and disease specific Kidney Disease Quality of Life-Short Form (KDQoL-SF questionnaires. Results: The study comprised 130 patients of both genders, mean age 62.7 ± 14.7 years. The prevalence of undernutrition ranged from 3.1% by BMI 25 also had worse scores in some QoL dimensions, but after adjustment the pattern was maintained only in the symptoms and problems dimension of KDQoL-SF (p = 0.011. Conclusion: Our study reveals that even in mildly undernourished HD patients, nutritional status has a significant impact in several QoL dimensions. The questionnaires used provided different, almost complementary perspectives, yet for daily practice EuroQoL is simpler. Assuring a good nutritional status, may positively influence QoL.

  13. Health-related quality of life of food allergic patients measured with generic and disease-specific questionnaires

    NARCIS (Netherlands)

    Flokstra-de Blok, B. M. J.; van der Velde, J. L.; Vlieg-Boerstra, B. J.; Oude Elberink, J. N. G.; DunnGalvin, A.; Hourihane, J. O'B.; Duiverman, E. J.; Dubois, A. E. J.

    2010-01-01

    P>Background: Health-related quality of life (HRQL) has never been measured with both generic and disease-specific questionnaires in the same group of food allergic patients. The aim of this study was to compare HRQL of food allergic patients as measured with generic and disease-specific questionnai

  14. Disease-specific quality-of-life measurement tools for haemophilia patients.

    Science.gov (United States)

    Remor, E; Young, N L; Von Mackensen, S; Lopatina, E G

    2004-10-01

    The purpose of this paper is to summarize the state of the art in measuring quality of life in haemophila populations. The paper reviews the measures recently included in haemophila trials in the published literature. It also summarizes the development of four new disease-specific measures of health-related quality of life. Two of these were developed for children (the Haemo-QoL and the CHO-KLAT), and two for adults (the Hemofilia-QoL and the Hemolatin-QoL). These new measures show promise for use in clinical trials. Further research is in progress to complete the psychometric testing and cross-cultural validation.

  15. Modeling the Cumulative Effects of Social Exposures on Health: Moving beyond Disease-Specific Models

    Directory of Open Access Journals (Sweden)

    Heather L. White

    2013-03-01

    Full Text Available The traditional explanatory models used in epidemiology are “disease specific”, identifying risk factors for specific health conditions. Yet social exposures lead to a generalized, cumulative health impact which may not be specific to one illness. Disease-specific models may therefore misestimate social factors’ effects on health. Using data from the Canadian Community Health Survey and Canada 2001 Census we construct and compare “disease-specific” and “generalized health impact” (GHI models to gauge the negative health effects of one social exposure: socioeconomic position (SEP. We use logistic and multinomial multilevel modeling with neighbourhood-level material deprivation, individual-level education and household income to compare and contrast the two approaches. In disease-specific models, the social determinants under study were each associated with the health conditions of interest. However, larger effect sizes were apparent when outcomes were modeled as compound health problems (0, 1, 2, or 3+ conditions using the GHI approach. To more accurately estimate social exposures’ impacts on population health, researchers should consider a GHI framework.

  16. Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro

    Directory of Open Access Journals (Sweden)

    Reto Eggenschwiler

    2011-01-01

    Full Text Available Direct reprogramming of somatic cells into pluripotent cells by retrovirus-mediated expression of OCT4, SOX2, KLF4, and C-MYC is a promising approach to derive disease-specific induced pluripotent stem cells (iPSCs. In this study, we focused on three murine models for metabolic liver disorders: the copper storage disorder Wilson's disease (toxic-milk mice, tyrosinemia type 1 (fumarylacetoacetate-hydrolase deficiency, FAH−/− mice, and alpha1-antitrypsin deficiency (PiZ mice. Colonies of iPSCs emerged 2-3 weeks after transduction of fibroblasts, prepared from each mouse strain, and were maintained as individual iPSC lines. RT-PCR and immunofluorescence analyses demonstrated the expression of endogenous pluripotency markers. Hepatic precursor cells could be derived from these disease-specific iPSCs applying an in vitro differentiation protocol and could be visualized after transduction of a lentiviral albumin-GFP reporter construct. Functional characterization of these cells allowed the recapitulation of the disease phenotype for further studies of underlying molecular mechanisms of the respective disease.

  17. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

    Directory of Open Access Journals (Sweden)

    Meng-Lu Liu

    2016-01-01

    Full Text Available Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS. Here, we show that adult human skin fibroblasts can be directly and efficiently converted into highly pure motor neurons without passing through an induced pluripotent stem cell stage. These adult human induced motor neurons (hiMNs exhibit the cytological and electrophysiological features of spinal motor neurons and form functional neuromuscular junctions (NMJs with skeletal muscles. Importantly, hiMNs converted from ALS patient fibroblasts show disease-specific degeneration manifested through poor survival, soma shrinkage, hypoactivity, and an inability to form NMJs. A chemical screen revealed that the degenerative features of ALS hiMNs can be remarkably rescued by the small molecule kenpaullone. Taken together, our results define a direct and efficient strategy to obtain disease-relevant neuronal subtypes from adult human patients and reveal their promising value in disease modeling and drug identification.

  18. Distinct trajectories of disease-specific health status in heart failure patients undergoing cardiac resynchronization therapy

    DEFF Research Database (Denmark)

    Mastenbroek, Mirjam H.; Pedersen, Susanne S.; Meine, Mathias;

    2016-01-01

    of 139 patients with a CRT-defibrillator (70 % men; age 65.7 ± 10.1 years) completed the Kansas City Cardiomyopathy Questionnaire (KCCQ) prior to implantation (baseline) and at 2, 6, and 12-14 months post-implantation. Latent class analyses were used to identify trajectories and associates of disease......-specific health status over time. RESULTS: All health status trajectories showed an initial small to large improvement from baseline to 2-month follow-up, whereafter most trajectories displayed a stable pattern between short- and long-term follow-up. Low educational level, NYHA class III/IV, smoking, no use...... of beta-blockers, use of psychotropic medication, anxiety, depression, and type D personality were found to be associated with poorer health status in unadjusted analyses. Interestingly, subgroups of patients (12-20 %) who experienced poor health status at baseline improved to stable good health status...

  19. A validated disease specific prediction equation for resting metabolic rate in underweight patients with COPD

    Directory of Open Access Journals (Sweden)

    Anita Nordenson

    2010-09-01

    Full Text Available Anita Nordenson2, Anne Marie Grönberg1,2, Lena Hulthén1, Sven Larsson2, Frode Slinde11Department of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden; 2Department of Internal Medicine/Respiratory Medicine and Allergology, Sahlgrenska Academy at University of Gothenburg, SwedenAbstract: Malnutrition is a serious condition in chronic obstructive pulmonary disease (COPD. Successful dietary intervention calls for calculations of resting metabolic rate (RMR. One disease-specific prediction equation for RMR exists based on mainly male patients. To construct a disease-specific equation for RMR based on measurements in underweight or weight-losing women and men with COPD, RMR was measured by indirect calorimetry in 30 women and 11 men with a diagnosis of COPD and body mass index <21 kg/m2. The following variables, possibly influencing RMR were measured: length, weight, middle upper arm circumference, triceps skinfold, body composition by dual energy x-ray absorptiometry and bioelectrical impedance, lung function, and markers of inflammation. Relations between RMR and measured variables were studied using univariate analysis according to Pearson. Gender and variables that were associated with RMR with a P value <0.15 were included in a forward multiple regression analysis. The best-fit multiple regression equation included only fat-free mass (FFM: RMR (kJ/day = 1856 + 76.0 FFM (kg. To conclude, FFM is the dominating factor influencing RMR. The developed equation can be used for prediction of RMR in underweight COPD patients.Keywords: pulmonary disease, chronic obstructive, basal metabolic rate, malnutrition, body composition

  20. Disease specific stress of tumor patients at the beginning of radiotherapy. Effect on psychosocial support requirement

    International Nuclear Information System (INIS)

    Purpose: Radiotherapy brings a tumor patient into a special life situation in which different variables play a role of often unknown importance. The goal of this study was to investigate disease specific stress of tumor patients at the beginning of radiotherapy with established psychodiagnostic questionnaires and to evaluate the effect on psychosocial support requirement in order to reduce stress and to improve quality of life and compliance during radiotherapeutical treatment. Patients and Methods: 732 patients were screened, of whom 446 (60.9%) fulfilled the criteria for inclusion (refusals 21.0%, low Karnofsky performance status 6.6%, management problems 3.4%, language barriers 3.0%, cognitive restrictions 2.6%, death 2.5%). Disease specific aspects of stress in the questionnaire (Fragebogen zur Belastung von Krebspatienten, FBK), life situation (LS) and self-defined care requirements (BB) were self-rated by patients with different tumor types before radiotherapy. Medical and sociodemographic data were also documented. We investigated 446 patients (262 male, 184 female; median age 60.0 years) with different diagnoses. Results: Stress was observed mainly due to reduction of efficiency, anxiety and pain on the subscales. Women had a significant higher stress on subscales of pain (p=0.016) and anxiety (p=0.009), patients younger than 45 years in the subscale information (p=0.002) and patients older than 45 and younger than 60 years in the subscale anxiety (p=0.002) and the total score (p=0.003). Patients with mamma carcinoma had the highest stress. The maximum percentages of patients under high stress were found for the subscales of efficiency (43%) and anxiety (40%). The support requirement was characterized by the need of more medical information and dialogue with the doctor. We saw a significant correlation of high stress and high care requirement. Conclusions: Psychosocial support should be founded on psychosocial stress diagnostic and self-defined care

  1. Disease-specific target gene expression profiling of molecular imaging probes: database development and clinical validation.

    Science.gov (United States)

    Chan, Lawrence Wing-Chi; Ngo, Connie Hiu-Ching; Wang, Fengfeng; Zhao, Moss Y; Zhao, Mengying; Law, Helen Ka-Wai; Wong, Sze Chuen Cesar; Yung, Benjamin Yat-Ming

    2014-01-01

    Molecular imaging probes can target abnormal gene expression patterns in patients and allow early diagnosis of disease. For selecting a suitable imaging probe, the current Molecular Imaging and Contrast Agent Database (MICAD) provides descriptive and qualitative information on imaging probe characteristics and properties. However, MICAD does not support linkage with the expression profiles of target genes. The proposed Disease-specific Imaging Probe Profiling (DIPP) database quantitatively archives and presents the gene expression profiles of targets across different diseases, anatomic regions, and subcellular locations, providing an objective reference for selecting imaging probes. The DIPP database was validated with a clinical positron emission tomography (PET) study on lung cancer and an in vitro study on neuroendocrine cancer. The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of 11C-choline and [18F]fluoro-2-deoxy-2-d-glucose (FDG), respectively. Their significant overexpressions corresponded to the findings that the uptake rate of FDG increased with tumor size but that of 11C-choline remained constant. Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http://www.polyu.edu.hk/bmi/dipp/. PMID:25022454

  2. The Liver Disease Symptom Index 2.0; validation of a disease-specific questionnaire.

    Science.gov (United States)

    van der Plas, Simone M; Hansen, Bettina E; de Boer, Josien B; Stijnen, Theo; Passchier, Jan; de Man, Rob A; Schalm, Solko W

    2004-10-01

    The available liver disease-specific questionnaires do address severity of symptoms but hardly evaluate how patients experience these specific symptoms during daily activities. The Liver Disease Symptom Index 2.0 (LDSI) includes 18 items that measure symptom severity and symptom hindrance in the past week. In a large survey (n = 1175) conducted in collaboration with the Dutch liver patient association, convergent and divergent construct validity and the surplus value of including symptom severity and symptom hindrance items in the LDSI were examined. The LDSI items showed expected convergent and divergent correlations with Short Form-36 (SF-36) and Multidimensional Fatigue Index-20 (MFI-20) scales. Correlations revealed only a slight to moderate overlap between LDSI items and SF-36 and MFI-20 scales. The impact of symptom severity and symptom hindrance on generic health related quality of life (HRQoL) varied in a different way across liver patients, which indicated that symptom severity items and the symptom hindrance items measure different aspects of HRQoL. We conclude that the LDSI provides information complementary to the information given by the SF-36 and the MFI-20 and that it is psychometrically sound to include both symptom severity items and symptom hindrance items in the LDSI. PMID:15503842

  3. The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

    Directory of Open Access Journals (Sweden)

    Proutski Vitali

    2010-12-01

    Full Text Available Abstract Background To date, there are no clinically reliable predictive markers of response to the current treatment regimens for advanced colorectal cancer. The aim of the current study was to compare and assess the power of transcriptional profiling using a generic microarray and a disease-specific transcriptome-based microarray. We also examined the biological and clinical relevance of the disease-specific transcriptome. Methods DNA microarray profiling was carried out on isogenic sensitive and 5-FU-resistant HCT116 colorectal cancer cell lines using the Affymetrix HG-U133 Plus2.0 array and the Almac Diagnostics Colorectal cancer disease specific Research tool. In addition, DNA microarray profiling was also carried out on pre-treatment metastatic colorectal cancer biopsies using the colorectal cancer disease specific Research tool. The two microarray platforms were compared based on detection of probesets and biological information. Results The results demonstrated that the disease-specific transcriptome-based microarray was able to out-perform the generic genomic-based microarray on a number of levels including detection of transcripts and pathway analysis. In addition, the disease-specific microarray contains a high percentage of antisense transcripts and further analysis demonstrated that a number of these exist in sense:antisense pairs. Comparison between cell line models and metastatic CRC patient biopsies further demonstrated that a number of the identified sense:antisense pairs were also detected in CRC patient biopsies, suggesting potential clinical relevance. Conclusions Analysis from our in vitro and clinical experiments has demonstrated that many transcripts exist in sense:antisense pairs including IGF2BP2, which may have a direct regulatory function in the context of colorectal cancer. While the functional relevance of the antisense transcripts has been established by many studies, their functional role is currently unclear

  4. Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy

    Energy Technology Data Exchange (ETDEWEB)

    Surova, Yulia; Hall, Sara; Widner, Haakan [Lund University, Department of Clinical Sciences, Lund (Sweden); Skaane University Hospital, Department of Neurology, Lund (Sweden); Nilsson, Markus [Lund University, Lund University Bioimaging Center, Lund (Sweden); Laett, Jimmy [Skaane University Hospital, Center for Medical Imaging and Physiology, Lund (Sweden); Lampinen, Bjoern [Lund University, Department of Medical Radiation Physics, Lund (Sweden); Lindberg, Olof [Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Nilsson, Christer [Skaane University Hospital, Department of Neurology, Lund (Sweden); Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Westen, Danielle van [Lund University, Department of Clinical Sciences, Lund (Sweden); Skaane University Hospital, Center for Medical Imaging and Physiology, Lund (Sweden); Hansson, Oskar [Malmoe, Lund University, Department of Clinical Sciences, Malmoe (Sweden); Skaane University Hospital, Memory Clinic, Lund (Sweden)

    2015-11-15

    The aim of this study is to identify disease-specific changes of the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), and multiple system atrophy with predominant parkinsonism (MSA-P) using diffusion tensor imaging and volumetric analysis. MRI diffusion and volumetric data were acquired in a derivation of 30 controls and 8 patients with PSP and a validation cohort comprised of controls (n = 21) and patients with PSP (n = 27), PD (n = 10), and MSA-P (n = 11). Analysis was performed using regions of interest (ROI), tract-based spatial statistic (TBSS), and tractography and results compared between diagnostic groups. In the derivation cohort, we observed increased mean diffusivity (MD) in the thalamus, superior cerebellar peduncle, and the midbrain in PSP compared to controls. Furthermore, volumetric analysis showed reduced thalamic volumes in PSP. In the validation cohort, the observations of increased MD were replicated by ROI-based analysis and in the thalamus by TBSS-based analysis. Such differences were not found for patients with PD in any of the cohorts. Tractography of the dentatorubrothalamic tract (DRTT) showed increased MD in PSP patients from both cohorts compared to controls and in the validation cohort in PSP compared to PD and MSA patients. Increased MD in the thalamus and along the DRTT correlated with disease stage and motor function in PSP. Patients with PSP, but not PD or MSA-P, exhibit signs of structural abnormalities in the thalamus and in the DRTT. These changes are associated with disease stage and impaired motor function. (orig.)

  5. Determinants of disease-specific health-related quality of life in Turkish stroke survivors.

    Science.gov (United States)

    Safaz, İsmail; Kesikburun, Serdar; Adigüzel, Emre; Yilmaz, Bilge

    2016-06-01

    Stroke is a worldwide cause of morbidity and mortality that affects health-related quality of life. In this study, our objective was to identify determinants of disease-specific health-related quality of life in Turkish stroke survivors. A total of 114 consecutive patients who experienced a stroke at least 6 months earlier were studied. Health-related quality of life was measured using Stroke-specific Quality of Life (SS-QoL) consisting of 12 domains. Demographic and clinical data were collected, including age, sex, marital status, years of education, time since stroke, whether the patient received rehabilitation before enrollment, stroke etiology, whether the dominant hand was affected or not, presence of vision defect, neglect, aphasia, and dysarthria. The patients were assessed by the functional independence measure (FIM) and the Mini-Mental State Examination. A multiple linear regression analysis was carried out using a stepwise method to determine the predictors of 12 domains and the total score of the SS-QoL. The domains of work, social roles, mobility, and self-care had the lowest SS-QoL scores, whereas the highest scores were for the domains of personality, thinking, language, and vision. The total SS-QoL score was explained by the total FIM and Mini-Mental State Examination. Among the 12 domains, the mobility domain was explained the best (R=0.50) by motor FIM, previously received rehabilitation, and age, followed by the language domain (R=0.37) explained by the presence of aphasia and dysarthria, and previously received rehabilitation. The domains of mood (R=0.13) and upper extremity (R=0.19) were explained the worst. The results indicated that functional independence, age, cognitive status, and receiving a rehabilitation program were the primary determinants of the SS-QoL. PMID:26795717

  6. Health literacy and disease-specific knowledge of caregivers for children with sickle cell disease.

    Science.gov (United States)

    Carden, Marcus A; Newlin, Jennifer; Smith, Wally; Sisler, India

    2016-03-01

    This study was conducted to measure the health literacy (HL) and disease-specific knowledge (DSK) of caregivers for children with sickle cell disease (SCD) and relate them to their child's health care utilization. The authors conducted a cross-sectional study of caregiver-child dyads attending an urban pediatric sickle cell clinic. Caregivers were administered the Shortened Test of Functional Health Literacy (S-TOFHLA) and a locally developed DSK questionnaire. Retrospective review of the child's electronic medical record (EMR) was performed to determine annual emergency department (ED) visits and hospitalizations. A total of 142 caregiver-child dyads were recruited for the study. Less than 5% of caregivers had limited HL, with less education (P =.03) and primary language other than English (P =.04) being the only risk factors. Although caregiver HL was not associated with ED visits or hospitalizations, surprisingly DSK was. Caregivers with higher DSK scores had children with higher annual rates of ED utilization (P =.002) and hospitalizations (P =.001), and these children were also more likely to be classified as high ED utilizers (≥4 visits per year; P =.01). Further, caregiver adherence to medication and clinic visits was associated with their child's age (P =.01). Although HL and DSK are both constructs that measure basic health understanding, they differently affect caregivers' ability to navigate and understand the health care system of children with chronic illnesses. This study suggests that the DSK/health care utilization relationship may be a more important measure than HL for programs following children with sickle cell disease and could also have applications in other pediatric chronic diseases. PMID:26934177

  7. Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy

    International Nuclear Information System (INIS)

    The aim of this study is to identify disease-specific changes of the thalamus, basal ganglia, pons, and midbrain in patients with progressive supranuclear palsy (PSP), Parkinson's disease (PD), and multiple system atrophy with predominant parkinsonism (MSA-P) using diffusion tensor imaging and volumetric analysis. MRI diffusion and volumetric data were acquired in a derivation of 30 controls and 8 patients with PSP and a validation cohort comprised of controls (n = 21) and patients with PSP (n = 27), PD (n = 10), and MSA-P (n = 11). Analysis was performed using regions of interest (ROI), tract-based spatial statistic (TBSS), and tractography and results compared between diagnostic groups. In the derivation cohort, we observed increased mean diffusivity (MD) in the thalamus, superior cerebellar peduncle, and the midbrain in PSP compared to controls. Furthermore, volumetric analysis showed reduced thalamic volumes in PSP. In the validation cohort, the observations of increased MD were replicated by ROI-based analysis and in the thalamus by TBSS-based analysis. Such differences were not found for patients with PD in any of the cohorts. Tractography of the dentatorubrothalamic tract (DRTT) showed increased MD in PSP patients from both cohorts compared to controls and in the validation cohort in PSP compared to PD and MSA patients. Increased MD in the thalamus and along the DRTT correlated with disease stage and motor function in PSP. Patients with PSP, but not PD or MSA-P, exhibit signs of structural abnormalities in the thalamus and in the DRTT. These changes are associated with disease stage and impaired motor function. (orig.)

  8. Fragrance allergy and quality of life - development and validation of a disease-specific quality of life instrument

    DEFF Research Database (Denmark)

    Heisterberg, Maria V; Menné, Torkil; Johansen, Jeanne D

    2014-01-01

    BACKGROUND: Fragrance allergy is a lifelong condition that may give rise to permanent or recurrent contact dermatitis and may affect quality of life (QoL). The effect on QoL has not yet been investigated, and no disease-specific QoL instrument for fragrance allergy exists. OBJECTIVE: To develop a...

  9. Step-by-step Guideline for disease-specific costing studies in low and middle income countries: a mixed methodology.

    NARCIS (Netherlands)

    M.E. Hendriks (Marleen); P. Kundu; A.C. Boers (Alexander); O.A. Bolarinwa (Oladimeji Akeem); M.J. te Pas (Mark); T.M. Akande (Tanimola); K. Agbede (Kayode); G.B. Gomez; W.K. Redekop (Ken); C. Schultsz (Constance); S.S. Tan (Siok Swan)

    2014-01-01

    markdownabstract__Abstract__ BACKGROUND: Disease-specific costing studies can be used as input into cost-effectiveness analyses and provide important information for efficient resource allocation. However, limited data availability and limited expertise constrain such studies in low- and middle-inc

  10. Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL) scale

    DEFF Research Database (Denmark)

    Berghöfer, P; Fragkos, K C; Baxter, J P;

    2013-01-01

    Subjects with short bowel syndrome (SBS) have impaired quality of life (QoL). No disease-specific instrument has been available to measure treatment-induced changes in QoL over time. Therefore, the aim was to develop and validate an SBS-specific QoL scale....

  11. Disease-specific health-related quality of life instruments for IgE-mediated food allergy

    NARCIS (Netherlands)

    Salvilla, S. A.; Dubois, A. E. J.; Flokstra-de Blok, Bertine; Panesar, S. S.; Worth, A.; Patel, S.; Muraro, A.; Halken, S.; Hoffmann-Sommergruber, K.; DunnGalvin, A.; Hourihane, J. O'B.; Regent, L.; de Jong, N. W.; Roberts, G.; Sheikh, A.

    2014-01-01

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are

  12. Disease-specific health-related quality of life instruments for IgE-mediated food allergy.

    Science.gov (United States)

    Salvilla, S A; Dubois, A E J; Flokstra-de Blok, B M J; Panesar, S S; Worth, A; Patel, S; Muraro, A; Halken, S; Hoffmann-Sommergruber, K; DunnGalvin, A; Hourihane, J O'B; Regent, L; de Jong, N W; Roberts, G; Sheikh, A

    2014-07-01

    This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages.

  13. Application of a disease-specific mapping function to estimate utility gains with effective treatment of schizophrenia

    Directory of Open Access Journals (Sweden)

    Rupnow Marcia FT

    2005-09-01

    Full Text Available Abstract Background Most tools for estimating utilities use clinical trial data from general health status models, such as the 36-Item Short-Form Health Survey (SF-36. A disease-specific model may be more appropriate. The objective of this study was to apply a disease-specific utility mapping function for schizophrenia to data from a large, 1-year, open-label study of long-acting risperidone and to compare its performance with an SF-36-based utility mapping function. Methods Patients with schizophrenia or schizoaffective disorder by DSM-IV criteria received 25, 50, or 75 mg long-acting risperidone every 2 weeks for 12 months. The Positive and Negative Syndrome Scale (PANSS and SF-36 were used to assess efficacy and health-related quality of life. Movement disorder severity was measured using the Extrapyramidal Symptom Rating Scale (ESRS; data concerning other common adverse effects (orthostatic hypotension, weight gain were collected. Transforms were applied to estimate utilities. Results A total of 474 patients completed the study. Long-acting risperidone treatment was associated with a utility gain of 0.051 using the disease-specific function. The estimated gain using an SF-36-based mapping function was smaller: 0.0285. Estimates of gains were only weakly correlated (r = 0.2. Because of differences in scaling and variance, the requisite sample size for a randomized trial to confirm observed effects is much smaller for the disease-specific mapping function (156 versus 672 total subjects. Conclusion Application of a disease-specific mapping function was feasible. Differences in scaling and precision suggest the clinically based mapping function has greater power than the SF-36-based measure to detect differences in utility.

  14. Disease-specific health-related quality of life instruments for IgE-mediated food allergy

    DEFF Research Database (Denmark)

    Salvilla, S A; Dubois, A E J; Flokstra-de Blok, B M J;

    2014-01-01

    of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy....... From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide...... a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments...

  15. Patient-perceived self-management tasks and support needs of people with chronic illness: generic or disease specific?

    OpenAIRE

    Houtum, L. van; Rijken, M; Heijmans, M.; Groenewegen, P

    2015-01-01

    Background: Self-management is widely accepted as an essential component of chronic care. Nevertheless, little is known about patients’ perceptions of self-management. Purpose: This study aims to explore which self-management tasks and support needs people with chronic illness perceive for themselves, and to establish whether these tasks and support needs are disease specific. Methods: A nationwide representative sample of 2,064 people with chronic disease filled in the Patient Assessment of ...

  16. Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation

    Directory of Open Access Journals (Sweden)

    Riedlinger Arne

    2009-10-01

    Full Text Available Abstract Background Disease-specific quality of life (QoL measures have enhanced the capacity of outcome measures to evaluate subtle changes and differences between groups. However, when the specific disease is rare, the cohort of patients is small and international collaboration is often necessary to accomplish meaningful research. As many of the QoL measures have been developed in North American English, they require translation to ensure their usefulness in a multi-cultural and/or international society. Published guidelines provide formal methods to achieve cross-culturally comparable versions of a QoL tool. However, these guidelines describe a rigorous process that is not always feasible, particularly in rare disease groups. The objective of this manuscript is to describe the process that was developed to achieve accurate cross-cultural translations of a disease-specific QoL measure, to overcome the challenges of a small sample size, i.e. children with a rare disorder. Procedure A measurement study was conducted in the United Kingdom (UK, France, Germany and Uruguay, during which the validated measure was translated into the languages of the respective countries. Results This is a report of a modified, child-centric, cross-cultural translation and adaptation process in which culturally appropriate and methodologically valid translations of a disease-specific QoL measure, the Kids' ITP Tools (KIT, were performed in children with immune thrombocytopenic purpura (ITP. The KIT was translated from North American English into UK English, French, German, and Spanish. Conclusion This study was a successful international collaboration. The modified process through which culturally appropriate and methodologically valid translations of QoL measures may be achieved in a pediatric population with a relatively rare disorder is reported.

  17. Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia.

    Science.gov (United States)

    Chen, Chengshui; Shi, Lin; Li, Yuping; Wang, Xiangdong; Yang, Shuanying

    2016-06-01

    Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome that occurs as a result of various risk factors, including either direct or indirect lung injury, and systemic inflammation triggered also by severe pneumonia (SP). SP-ARDS-associated morbidity and mortality remains high also due to the lack of disease-specific biomarkers. The present study aimed at identifying disease-specific biomarkers in SP or SP-ARDS by integrating proteomic profiles of inflammatory mediators with clinical informatics. Plasma was sampled from the healthy as controls or patients with SP infected with bacteria or infection-associated SP-ARDS on the day of admission, day 3, and day 7. About 15 or 52 cytokines showed significant difference between SP and SP-ARDS patients with controls or 13 between SP-ARDS with SP alone and controls, including bone morphogenetic protein-15 (BMP-15), chemokine (C-X-C motif) ligand 16 (CXCL16), chemokine (C-X-C motif) receptor 3 (CXCR3), interleukin-6 (IL-6), protein NOV homolog (NOV/CCN3), glypican 3, insulin-like growth factor binding protein 4 (IGFBP-4), IL-5, IL-5 R alpha, IL-22 BP, leptin, MIP-1d, and orexin B with a significant correlation with Digital Evaluation Score System (DESS) scores. ARDS patients with overexpressed IL-6, CXCL16, or IGFBP-4 had significantly longer hospital stay and higher incidence of secondary infection. We also found higher levels of those mediators were associated with poor survival rates in patients with lung cancer and involved in the process of the epithelial mesenchymal transition of alveolar epithelial cells. Our preliminary study suggested that integration of proteomic profiles with clinical informatics as part of clinical bioinformatics is important to validate and optimize disease-specific and disease-staged biomarkers. PMID:27095254

  18. General and disease-specific quality of life in patients with chronic suppurative otitis media - a prospective study

    Directory of Open Access Journals (Sweden)

    Plinkert Peter K

    2011-06-01

    Full Text Available Abstract Background Chronic suppurative otitis media (CSOM is frequently associated with symptoms of inflammation like discharge from the ear or pain. In many cases, patients suffer from hearing loss causing communication problems and social withdrawal. The objective of this work was to collect prospective audiological data and data on general and disease-specific quality of life with validated quality of life measurement instruments to assess the impact of the disease on health-related quality of life (HR-QOL. Methods 121 patients were included in the study. Patients were clinically examined in the hospital before and 6 months after surgery including audiological testing. They filled in the quality of life questionnaires SF-36 and Chronic Otitis Media Outcome Test 15 (COMOT-15 pre-operatively and 6 and 12 months post-operatively, respectively. Results Complete data records from 90 patients were available for statistical analysis. Disease-specific HR-QOL in patients with CSOM improved after tympanoplasty in all the scales of the COMOT-15. There was no difference in HR-QOL assessment between patients with mesotympanic respectively epitympanic CSOM. However, we did find the outcome to be worse in patients who received revision surgery compared with those receiving primary surgery. Audiometric findings correlated very well with the subscale hearing function from the COMOT-15 questionnaire. General HR-QOL measured with the SF-36 was not significantly changed by tympanoplasty. Conclusions Tympanoplasty did lead to a significant improvement of disease-specific HR-QOL in patients with CSOM while general HR-QOL did not change. Very well correlations were found between the subscale hearing function from the COMOT-15 questionnaire and audiological findings. Revision surgery seems to be a predictor for a worse outcome.

  19. Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women.

    Science.gov (United States)

    Hodgson, Jonathan M; Prince, Richard L; Woodman, Richard J; Bondonno, Catherine P; Ivey, Kerry L; Bondonno, Nicola; Rimm, Eric B; Ward, Natalie C; Croft, Kevin D; Lewis, Joshua R

    2016-03-14

    Higher fruit intake is associated with lower risk of all-cause and disease-specific mortality. However, data on individual fruits are limited, and the generalisability of these findings to the elderly remains uncertain. The objective of this study was to examine the association of apple intake with all-cause and disease-specific mortality over 15 years in a cohort of women aged over 70 years. Secondary analyses explored relationships of other fruits with mortality outcomes. Usual fruit intake was assessed in 1456 women using a FFQ. Incidence of all-cause and disease-specific mortality over 15 years was determined through the Western Australian Hospital Morbidity Data system. Cox regression was used to determine the hazard ratios (HR) for mortality. During 15 years of follow-up, 607 (41·7%) women died from any cause. In the multivariable-adjusted analysis, the HR for all-cause mortality was 0·89 (95% CI 0·81, 0·97) per sd (53 g/d) increase in apple intake, HR 0·80 (95% CI 0·65, 0·98) for consumption of 5-100 g/d and HR 0·65 (95% CI 0·48, 0·89) for consumption of >100 g/d (an apple a day), compared with apple intake of apple intake was associated with lower risk for cancer mortality, and that higher total fruit and banana intakes were associated lower risk of CVD mortality (Papple consumption may contribute to lower risk of mortality.

  20. Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD

    OpenAIRE

    Kinnula Vuokko L; Lindqvist Ari; Sintonen Harri; Kilpeläinen Maritta; Pitkäniemi Janne; Kupiainen Henna; Mazur Witold; Laitinen Tarja

    2011-01-01

    Abstract Background Given that the assessment of health-related quality of life (HRQoL) is an essential outcome measure to optimize chronic obstructive pulmonary disease (COPD) patient management, there is a need for a short and fast, reliable and valid instrument for routine use in clinical practice. The objective of this study was to analyse the relationship between the disease-specific Airways questionnaire (AQ20) and the generic 15D health-related quality of life (HRQoL) instrument simult...

  1. Validation of a New Questionnaire with Generic and Disease-Specific Qualities: The Mcgill Copd Quality of Life Questionnaire

    Directory of Open Access Journals (Sweden)

    Smita Pakhale

    2012-01-01

    Full Text Available BACKGROUND: A validated health-related quality of life questionnaire in chronic obstructive pulmonary disease (COPD with advantages of both generic- and disease-specific questionnaires is needed to capture patients’ perspectives of severity and impact of the disease. The McGill COPD questionnaire was created to include these advantages in English and French. It assesses three domains: symptoms, physical function and feelings with 29 items (12 from the 36-item Short-Form Health Survey with 17 from the previously developed COPD-specific module.

  2. Entrapment of alpha1-acid glycoprotein in high-performance affinity columns for drug-protein binding studies.

    Science.gov (United States)

    Bi, Cong; Jackson, Abby; Vargas-Badilla, John; Li, Rong; Rada, Giana; Anguizola, Jeanethe; Pfaunmiller, Erika; Hage, David S

    2016-05-15

    A slurry-based method was developed for the entrapment of alpha1-acid glycoprotein (AGP) for use in high-performance affinity chromatography to study drug interactions with this serum protein. Entrapment was achieved based on the physical containment of AGP in hydrazide-activated porous silica supports and by using mildly oxidized glycogen as a capping agent. The conditions needed for this process were examined and optimized. When this type of AGP column was used in binding studies, the association equilibrium constant (Ka) measured by frontal analysis at pH 7.4 and 37°C for carbamazepine with AGP was found to be 1.0 (±0.5)×10(5)M(-1), which agreed with a previously reported value of 1.0 (±0.1)×10(5)M(-1). Binding studies based on zonal elution were conducted for several other drugs with such columns, giving equilibrium constants that were consistent with literature values. An entrapped AGP column was also used in combination with a column containing entrapped HSA in a screening assay format to compare the binding of various drugs to AGP and HSA. These results also agreed with previous data that have been reported in literature for both of these proteins. The same entrapment method could be extended to other proteins and to the investigation of additional types of drug-protein interactions. Potential applications include the rapid quantitative analysis of biological interactions and the high-throughput screening of drug candidates for their binding to a given protein.

  3. High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Sofia B Gustafsson

    Full Text Available BACKGROUND: There is good evidence in the literature that the cannabinoid system is disturbed in colorectal cancer. In the present study, we have investigated whether CB(1 receptor immunoreactive intensity (CB(1IR intensity is associated with disease severity and outcome. METHODOLOGY/PRINCIPAL FINDINGS: CB(1IR was assessed in formalin-fixed, paraffin-embedded specimens collected with a consecutive intent during primary tumour surgical resection from a series of cases diagnosed with colorectal cancer. Tumour centre (n = 483 and invasive front (n = 486 CB(1IR was scored from 0 (absent to 3 (intense staining and the data was analysed as a median split i.e. CB(1IR <2 and ≥2. In microsatellite stable, but not microsatellite instable tumours (as adjudged on the basis of immunohistochemical determination of four mismatch repair proteins, there was a significant positive association of the tumour grade with the CB(1IR intensity. The difference between the microsatellite stable and instable tumours for this association of CB(1IR was related to the CpG island methylation status of the cases. Cox proportional hazards regression analyses indicated a significant contribution of CB(1IR to disease-specific survival in the microsatellite stable tumours when adjusting for tumour stage. For the cases with stage II microsatellite stable tumours, there was a significant effect of both tumour centre and front CB(1IR upon disease specific survival. The 5 year probabilities of event-free survival were: 85±5 and 66±8%; tumour interior, 86±4% and 63±8% for the CB(1IR<2 and CB(1IR≥2 groups, respectively. CONCLUSIONS/SIGNIFICANCE: The level of CB(1 receptor expression in colorectal cancer is associated with the tumour grade in a manner dependent upon the degree of CpG hypermethylation. A high CB(1IR is indicative of a poorer prognosis in stage II microsatellite stable tumour patients.

  4. Measuring disease-specific health status in men with benign prostatic hyperplasia. Measurement Committee of The American Urological Association.

    Science.gov (United States)

    Barry, M J; Fowler, F J; O'Leary, M P; Bruskewitz, R C; Holtgrewe, H L; Mebust, W K

    1995-04-01

    In preparation for an outcomes study of benign prostatic hyperplasia (BPH), two measures of disease-specific health status were developed to supplement a symptom score and overall health status measures. The symptom problem index (SPI) captures how troublesome patients find their urinary symptoms. The BPH impact index (BII) measures how much their urinary problems affect various domains of health. A prospective revalidation of the refined instruments (N = 108 BPH patients and 50 controls) documented that both indices had good internal consistency (Cronbach's alpha = 0.88 and 0.79, respectively) and test-retest (r = 0.88 for both) reliabilities, correlated strongly with symptom scores (r = 0.86 and 0.77), and discriminated between BPH and control subjects (receiver-operating characteristic areas = 0.87 and 0.85, respectively). These indices were nearly as responsive as symptom scores in 50 men actively treated for BPH, and much more responsive than a non-disease-specific General Health Index (GHI), a Mental Health Index (MHI), and an Activity Index (AI). Finally, these measures capture most of the health status significance of BPH symptoms. In linear regression models constructed to predict scores on the GHI, MHI, and AI, symptom scores added little explanatory power to the SPI and, particularly, to the BII. These measures help clarify how BPH affects overall health status and function. Such measures have an important role to play in studies of the outcomes of treatment for BPH, and probably for other conditions that interfere with health status and function.

  5. Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study.

    Science.gov (United States)

    Chen, Hong; Song, Zhenju; Qian, Mengjia; Bai, Chunxue; Wang, Xiangdong

    2012-06-01

    Systemic inflammation is a major factor influencing the outcome and quality of patient with chronic obstructive pulmonary disease (COPD) and acute exacerbations (AECOPD). Because of the inflammatory complexity, a great challenge is still confronted to optimize the identification and validation of disease-specific biomarkers. This study aimed at developing a new protocol of specific biomarker evaluation by integrating proteomic profiles of inflammatory mediators with clinical informatics in AECOPD patients, understand better their function and signal networks. Plasma samples were collected from healthy non-smokers or patients with stable COPD (sCOPD) or AECOPD on days 1 and 3 of the admission and discharging day (day 7-10). Forty chemokines were measured using a chemokine multiplex antibody array. Clinical informatics was achieved by a Digital Evaluation Score System (DESS) for assessing severity of patients. Chemokine data was compared among different groups and its correlation with DESS scores was performed by SPSS software. Of 40 chemokines, 30 showed significant difference between sCOPD patients and healthy controls, 16 between AECOPD patients and controls and 13 between AECOPD patients and both sCOPD and controls, including BTC, IL-9, IL-18Bpa, CCL22,CCL23, CCL25, CCL28, CTACK, LIGHT, MSPa, MCP-3, MCP-4 and OPN. Of them, some had significant correlation with DESS scores. There is a disease-specific profile of inflammatory mediators in COPD and AECOPD patients which may have a potential diagnostics together with clinical informatics of patients. Our preliminary study suggested that integration of proteomics with clinical informatics can be a new way to validate and optimize disease-special biomarkers. PMID:21883889

  6. Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2.

    Science.gov (United States)

    Fogel, Brent L; Cho, Ellen; Wahnich, Amanda; Gao, Fuying; Becherel, Olivier J; Wang, Xizhe; Fike, Francesca; Chen, Leslie; Criscuolo, Chiara; De Michele, Giuseppe; Filla, Alessandro; Collins, Abigail; Hahn, Angelika F; Gatti, Richard A; Konopka, Genevieve; Perlman, Susan; Lavin, Martin F; Geschwind, Daniel H; Coppola, Giovanni

    2014-09-15

    Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To assess the functional role of senataxin in disease, we examined differential gene expression in AOA2 patient fibroblasts, identifying a core set of genes showing altered expression by microarray and RNA-sequencing. To determine whether AOA2 and ALS4 mutations differentially affect gene expression, we overexpressed disease-specific SETX mutations in senataxin-haploinsufficient fibroblasts and observed changes in distinct sets of genes. This implicates mutation-specific alterations of senataxin function in disease pathogenesis and provides a novel example of allelic neurogenetic disorders with differing gene expression profiles. Weighted gene co-expression network analysis (WGCNA) demonstrated these senataxin-associated genes to be involved in both mutation-specific and shared functional gene networks. To assess this in vivo, we performed gene expression analysis on peripheral blood from members of 12 different AOA2 families and identified an AOA2-specific transcriptional signature. WGCNA identified two gene modules highly enriched for this transcriptional signature in the peripheral blood of all AOA2 patients studied. These modules were disease-specific and preserved in patient fibroblasts and in the cerebellum of Setx knockout mice demonstrating conservation across species and cell types, including neurons. These results identify novel genes and cellular pathways related to senataxin function in normal and disease states, and implicate alterations in gene expression as underlying the phenotypic differences between AOA2 and ALS4. PMID:24760770

  7. Simple and Rapid Hollow Fiber Liquid Phase Microextraction Followed by High Performance Liquid Chromatography Method for Determination of Drug-protein Binding

    Institute of Scientific and Technical Information of China (English)

    XI Guo-chen; HU Shuang; BAI Xiao-hong

    2011-01-01

    A method was established using hollow fiber-liquid phase microextraction(HF-LPME) followed by high performance liquid chromatography(HPLC) to determine the concentration of the free(unbound) drug in the solution of the drug and protein.Measurements of drug-protein binding ratios and free drug concentrations were then analyzed with the Klotz equation to determine the equilibrium binding constant and number of binding sites for drug-protein interaction.The optimized method allows one to perform the efficient extraction and separation of free drug from protein-bound drug,protein,and other interfering substances.This approach was used to characterize the binding of the anticholinergic drugs atropine sulfate and scopolamine hydrobromide to proteins in human plasma and bovine serum albumin(BSA).The results demonstrate the utility of HF-LPME method for measuring free drug concentrations in protein-drug mixtures and determining the protein binding parameters of a pharmacologically important class of drugs.

  8. Discriminative and predictive properties of disease-specific and generic health status indexes in elderly COPD patients

    Directory of Open Access Journals (Sweden)

    Forastiere Francesco

    2008-08-01

    Full Text Available Abstract Background The association between bronchial obstruction severity and mortality in Chronic Obstructive Pulmonary Disease (COPD is well established, but it is unknown whether disease-specific health status measures and multidimensional assessment (MDA have comparable prognostic value. Methods We analyzed data coming from the Salute Respiratoria nell'Anziano (Respiratory Health in the Elderly – SaRA study, enrolling elderly people attending outpatient clinics for respiratory and non-respiratory problems. From this population we selected 449 patients with bronchial obstruction (77.3% men, mean age 73.1. We classified patients' health status using tertiles of the Saint George Respiratory Questionnaire (SGRQ and a MDA including functional (the 6' walking test, WT, cognitive (Mini-Mental State Examination, MMSE and affective status (Geriatric Depression Scale, GDS. The agreement of the classification methods was calculated using the kappa statistic, and survival associated with group membership was evaluated using survival analysis. Results Pulmonary function, expressed by the FEV1, worsened with increasing SGRQ or MDA scores. Cognitive function was not associated with the SGRQ, while physical performance and mood status were impaired only in the highest tertile of SGRQ. A poor agreement was found between the two classification systems tested (k = 0.194. Compared to people in the first tertile of SGRQ score, those in the second tertile had a sex-adjusted HR of 1.22 (0.75 – 1.98 and those in the third tertile of 2.90 (1.92 – 4.40. The corresponding figures of the MDA were 1.49 (95% CI 1.02 – 2.18 and 2.01 (95% CI: 1.31 – 3.08. After adjustment for severity of obstruction, only a SGRQ in the upper tertile was associated with mortality (HR: 1.86; 95% CI: 1.14 – 3.02. Conclusion In elderly outpatients with mild-moderate COPD, a disease-specific health status index seems to be a better predictor of death compared to a MDA.

  9. Serum Metabolomics to Identify the Liver Disease-Specific Biomarkers for the Progression of Hepatitis to Hepatocellular Carcinoma

    Science.gov (United States)

    Gao, Rong; Cheng, Jianhua; Fan, Chunlei; Shi, Xiaofeng; Cao, Yuan; Sun, Bo; Ding, Huiguo; Hu, Chengjin; Dong, Fangting; Yan, Xianzhong

    2015-12-01

    Hepatocellular carcinoma (HCC) is a common malignancy that has region specific etiologies. Unfortunately, 85% of cases of HCC are diagnosed at an advanced stage. Reliable biomarkers for the early diagnosis of HCC are urgently required to reduced mortality and therapeutic expenditure. We established a non-targeted gas chromatography-time of flight-mass spectrometry (GC-TOFMS) metabolomics method in conjunction with Random Forests (RF) analysis based on 201 serum samples from healthy controls (NC), hepatitis B virus (HBV), liver cirrhosis (LC) and HCC patients to explore the metabolic characteristics in the progression of hepatocellular carcinogenesis. Ultimately, 15 metabolites were identified intimately associated with the process. Phenylalanine, malic acid and 5-methoxytryptamine for HBV vs. NC, palmitic acid for LC vs. HBV, and asparagine and β-glutamate for HCC vs. LC were screened as the liver disease-specific potential biomarkers with an excellent discriminant performance. All the metabolic perturbations in these liver diseases are associated with pathways for energy metabolism, macromolecular synthesis, and maintaining the redox balance to protect tumor cells from oxidative stress.

  10. Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

    Science.gov (United States)

    Gu, Xiaolian; Boldrup, Linda; Coates, Philip J.; Fahraeus, Robin; Nylander, Elisabet; Loizou, Christos; Olofsson, Katarina; Norberg-Spaak, Lena; Gärskog, Ola; Nylander, Karin

    2016-01-01

    Epigenetic modifications are essential regulators of biological processes. Decreased DNA methylation of OAS2 (2′-5′-Oligoadenylate Synthetase 2), encoding an antiviral protein, has been seen in psoriasis. To provide further insight into the epigenetic regulation of OAS2, we performed pyrosequencing to detect OAS2 DNA methylation status at 11 promoter and first exon located CpG sites in psoriasis (n = 12) and two common subtypes of squamous cell carcinoma (SCC) of the head and neck: tongue (n = 12) and tonsillar (n = 11). Compared to corresponding controls, a general hypomethylation was seen in psoriasis. In tongue and tonsillar SCC, hypomethylation was found at only two CpG sites, the same two sites that were least demethylated in psoriasis. Despite differences in the specific residues targeted for methylation/demethylation, OAS2 expression was upregulated in all conditions and correlations between methylation and expression were seen in psoriasis and tongue SCC. Distinctive methylation status at four successively located CpG sites within a genomic area of 63 bp reveals a delicately integrated epigenetic program and indicates that detailed analysis of individual CpGs provides additional information into the mechanisms of epigenetic regulation in specific disease states. Methylation analyses as clinical biomarkers need to be tailored according to disease-specific sites. PMID:27572959

  11. Comparison between the disease-specific Airways Questionnaire 20 and the generic 15D instruments in COPD

    Directory of Open Access Journals (Sweden)

    Kinnula Vuokko L

    2011-01-01

    Full Text Available Abstract Background Given that the assessment of health-related quality of life (HRQoL is an essential outcome measure to optimize chronic obstructive pulmonary disease (COPD patient management, there is a need for a short and fast, reliable and valid instrument for routine use in clinical practice. The objective of this study was to analyse the relationship between the disease-specific Airways questionnaire (AQ20 and the generic 15D health-related quality of life (HRQoL instrument simultaneously in a large cohort of patients with COPD. We also compare the HRQoL of COPD patients with that of the general population. Methods The AQ20 and 15D were administered to 739 COPD patients representing an unselected hospital-based COPD population. The completion rates and validity of, and correlations among the questions and dimension scores were examined. A factor analysis with varimax rotation was performed in order to find subsets of highly correlating items of the questionnaires. Results The summary scores of AQ20 and 15D were highly correlated (r = - 0.71, p Conclusions The AQ20 and 15D summary scores are comparable in terms of measuring HRQoL in COPD patients. The data support the validity of 15D to measure the quality of life in COPD. COPD compromises the HRQoL broadly, as reflected by the generic instrument. Both questionnaires are simple and short, and could easily be used in clinical practice with high completion rates.

  12. Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

    Directory of Open Access Journals (Sweden)

    Jiang Wei

    2008-08-01

    the sub-network that consisted of three-way gene interactions suggested that tumourigenesis in colon cancer resulted from dysfunction in protein biosynthesis and categories associated with ribonucleoprotein complex which are well supported by multiple lines of experimental evidence. Conclusion This study demonstrated that IL8, DES and ENO1 act as the central elements in colon cancer susceptibility, and protein biosynthesis and the ribosome-associated function categories largely account for the colon cancer tumuorigenesis. Thus, the newly developed relevancy-based networking approach offers a powerful means to reverse-engineer the disease-specific network, a promising tool for systematic dissection of complex diseases.

  13. Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

    Directory of Open Access Journals (Sweden)

    Mario U Manto

    2015-03-01

    Full Text Available Autoantibodies to the smaller isoform of glutamate decarboxylase can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis. The detection of disease-specific autoantibody epitopes led to the hypothesis that distinct glutamate decarboxylase autoantibodies may elicit specific neurological phenotypes. We explored the in vitro/in vivo effects of well-characterized monoclonal glutamate decarboxylase antibodies. We found that glutamate decarboxylase autoantibodies present in patients with stiff person syndrome (n = 7 and cerebellar ataxia (n = 15 recognized an epitope distinct from that recognized by glutamate decarboxylase autoantibodies present in patients with type 1 diabetes mellitus (n = 10 or limbic encephalitis (n = 4. We demonstrated that the administration of a monoclonal glutamate decarboxylase antibody representing this epitope specificity (1 disrupted in vitro the association of glutamate decarboxylase with γ-Aminobutyric acid containing synaptic vesicles, (2 depressed the inhibitory synaptic transmission in cerebellar slices with a gradual time course and a lasting suppressive effect, (3 significantly decreased conditioned eyelid responses evoked in mice, with no modification of learning curves in the classical eyeblink-conditioning task, (4 markedly impaired the facilitatory effect exerted by the premotor cortex over the motor cortex in a paired-pulse stimulation paradigm, and (5 induced decreased exploratory behavior and impaired locomotor function in rats. These findings support the specific targeting of glutamate decarboxylase by its autoantibodies in the pathogenesis of stiff-person syndrome and cerebellar ataxia. Therapies of these disorders based on selective removal of such glutamate decarboxylase antibodies could be envisioned.

  14. DrugLogit: logistic discrimination between drugs and nondrugs including disease-specificity by assigning probabilities based on molecular properties.

    Science.gov (United States)

    García-Sosa, Alfonso T; Oja, Mare; Hetényi, Csaba; Maran, Uko

    2012-08-27

    The increasing knowledge of both structure and activity of compounds provides a good basis for enhancing the pharmacological characterization of chemical libraries. In addition, pharmacology can be seen as incorporating both advances from molecular biology as well as chemical sciences, with innovative insight provided from studying target-ligand data from a ligand molecular point of view. Predictions and profiling of libraries of drug candidates have previously focused mainly on certain cases of oral bioavailability. Inclusion of other administration routes and disease-specificity would improve the precision of drug profiling. In this work, recent data are extended, and a probability-based approach is introduced for quantitative and gradual classification of compounds into categories of drugs/nondrugs, as well as for disease- or organ-specificity. Using experimental data of over 1067 compounds and multivariate logistic regressions, the classification shows good performance in training and independent test cases. The regressions have high statistical significance in terms of the robustness of coefficients and 95% confidence intervals provided by a 1000-fold bootstrapping resampling. Besides their good predictive power, the classification functions remain chemically interpretable, containing only one to five variables in total, and the physicochemical terms involved can be easily calculated. The present approach is useful for an improved description and filtering of compound libraries. It can also be applied sequentially or in combinations of filters, as well as adapted to particular use cases. The scores and equations may be able to suggest possible routes for compound or library modification. The data is made available for reuse by others, and the equations are freely accessible at http://hermes.chem.ut.ee/~alfx/druglogit.html.

  15. Disease-specific health-related quality of life and its determinants in liver cirrhosis patients in Lithuania

    Institute of Scientific and Technical Information of China (English)

    Jolanta Sumskiene; Linas Sumskas; Dalius Petrauskas; Limas Kupcinskas

    2006-01-01

    AIM: To evaluate disease-specific quality of life (QOL) in liver cirrhosis patients and to compare it with those of a healthy population. Also an important objective was to assess whether QOL in liver cirrhosis patients differs by age and gender, by type and severity of disease.METHODS: The case group of 131 liver cirrhosis patients was selected. The control group of 262 was enrolled from a healthy population according to the scheme of case-control study. Clinical, demographic,laboratory data were collected. QOL was measured with a specific chronic liver disease questionnaire (CLDQ),which was translated and validated in Lithuanian.QOL scores were compared between groups by age,gender, type and severity of disease. Cronbach's alpha statistics calculation was used for evaluation of internal consistency reliability. Student's t test or ANOVA were used for evaluation hypothesis about probability equation.RESULTS: QOL was significantly lower in liver cirrhosis patients than in healthy population (59.5 ± 18.3 vs 85.3± 12.3, P < 0.001). The significant QOL differences between case and control groups were observed in domains of worry and abdominal symptoms, the smaller differences-in emotional functions and systematic symptom domains. Significantly worse QOL was in observed patients with increased clinical severity of the disease measured by Child-Pugh class. Age, gender and etiology of disease had an insignificant effect on QOL in cirrhotic patients.CONCLUSION: QOL was significantly impaired in all CLDQ domains in liver cirrhosis patients. Increase in severity of disease was the major factor associated with poorer QOL.

  16. Validation study of the prototype of a disease-specific index measure for health-related quality of life in dementia

    NARCIS (Netherlands)

    Scholzel-Dorenbos, Carla J. M.; Arons, Alexander M. M.; Wammes, Joost J. G.; Rikkert, Marcel G. M. Olde; Krabbe, Paul F. M.

    2012-01-01

    BACKGROUND: Index measures for health-related quality of life (HRQoL) quantify the desirability (utility) of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific inde

  17. Comparison of internal and external responsiveness of the generic Medical Outcome Study Short Form-36 (SF-36) with disease-specific measures in rheumatoid arthritis

    NARCIS (Netherlands)

    Veehof, Martine M.; Klooster, ten Peter M.; Taal, Erik; Riel, van Piet L.C.M.; Laar, van de Mart A.F.J.

    2008-01-01

    OBJECTIVE: To examine the comparative internal and external responsiveness of the generic Medical Outcome Study Short Form-36 Health Survey (SF-36) and disease-specific measures in patients with rheumatoid arthritis (RA). METHODS: Data were collected from 280 RA patients starting anti-tumor necrosis

  18. Comparison of internal and external responsiveness of the generic Medical Outcome Study Short Form-36 (SF-36) with disease-specific measures in rheumatoid arthritis.

    NARCIS (Netherlands)

    Veehof, M.M.; Klooster, PM ten; Taal, E.; Riel, P.L.C.M. van; Laar, M.A.A.M. van de

    2008-01-01

    OBJECTIVE: To examine the comparative internal and external responsiveness of the generic Medical Outcome Study Short Form-36 Health Survey (SF-36) and disease-specific measures in patients with rheumatoid arthritis (RA). METHODS: Data were collected from 280 RA patients starting anti-tumor necrosis

  19. On-column entrapment of alpha1-acid glycoprotein for studies of drug-protein binding by high-performance affinity chromatography.

    Science.gov (United States)

    Anguizola, Jeanethe; Bi, Cong; Koke, Michelle; Jackson, Abby; Hage, David S

    2016-08-01

    An on-column approach for protein entrapment was developed to immobilize alpha1-acid glycoprotein (AGP) for drug-protein binding studies based on high-performance affinity chromatography. Soluble AGP was physically entrapped by using microcolumns that contained hydrazide-activated porous silica and by employing mildly oxidized glycogen as a capping agent. Three on-column entrapment methods were evaluated and compared to a previous slurry-based entrapment method. The final selected method was used to prepare 1.0 cm × 2.1 mm I.D. affinity microcolumns that contained up to 21 (±4) μg AGP and that could be used over the course of more than 150 sample applications. Frontal analysis and zonal elution studies were performed on these affinity microcolumns to examine the binding of various drugs with the entrapped AGP. Site-selective competition studies were also conducted for these drugs. The results showed good agreement with previous observations for these drug-protein systems and with binding constants that have been reported in the literature. The entrapment method developed in this study should be useful for future work in the area of personalized medicine and in the high-throughput screening of drug interactions with AGP or other proteins. Graphical abstract On-column protein entrapment using a hydrazide-activated support and oxidized glycogen as a capping agent.

  20. Reactor building

    International Nuclear Information System (INIS)

    The whole reactor building is accommodated in a shaft and is sealed level with the earth's surface by a building ceiling, which provides protection against penetration due to external effects. The building ceiling is supported on walls of the reactor building, which line the shaft and transfer the vertical components of forces to the foundations. The thickness of the walls is designed to withstand horizontal pressure waves in the floor. The building ceiling has an opening above the reactor, which must be closed by cover plates. Operating equipment for the reactor can be situated above the building ceiling. (orig./HP)

  1. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    IBACOS researched the constructability and viability issues of using high performance windows as one component of a larger approach to building houses that achieve the Building America 70% energy savings target.

  2. Solar building

    OpenAIRE

    Zhang, Luxin

    2014-01-01

    In my thesis I describe the utilization of solar energy and solar energy with building integration. In introduction it is also mentioned how the solar building works, trying to make more people understand and accept the solar building. The thesis introduces different types of solar heat collectors. I compared the difference two operation modes of solar water heating system and created examples of solar water system selection. I also introduced other solar building applications. It is conv...

  3. The challenges of reshaping disease specific and care oriented community based services towards comprehensive goals: a situation appraisal in the Western Cape Province, South Africa

    OpenAIRE

    Schneider, Helen; Schaay, Nikki; Dudley, Lilian; Goliath, Charlyn; Qukula, Tobeka

    2015-01-01

    Background Similar to other countries in the region, South Africa is currently reorienting a loosely structured and highly diverse community care system that evolved around HIV and TB, into a formalized, comprehensive and integrated primary health care outreach programme, based on community health workers (CHWs). While the difficulties of establishing national CHW programmes are well described, the reshaping of disease specific and care oriented community services, based outside the formal he...

  4. Analysis of drug-protein binding using on-line immunoextraction and high-performance affinity microcolumns: Studies with normal and glycated human serum albumin.

    Science.gov (United States)

    Matsuda, Ryan; Jobe, Donald; Beyersdorf, Jared; Hage, David S

    2015-10-16

    A method combining on-line immunoextraction microcolumns with high-performance affinity chromatography (HPAC) was developed and tested for use in examining drug-protein interactions with normal or modified proteins. Normal human serum albumin (HSA) and glycated HSA were used as model proteins for this work. High-performance immunoextraction microcolumns with sizes of 1.0-2.0 cm × 2.1mm i.d. and containing anti-HSA polyclonal antibodies were developed and tested for their ability to bind normal HSA or glycated HSA. These microcolumns were able to extract up to 82-93% for either type of protein at 0.05-0.10 mL/min and had a binding capacity of 0.34-0.42 nmol HSA for a 1.0 cm × 2.1mm i.d. microcolumn. The immunoextraction microcolumns and their adsorbed proteins were tested for use in various approaches for drug binding studies. Frontal analysis was used with the adsorbed HSA/glycated HSA to measure the overall affinities of these proteins for the drugs warfarin and gliclazide, giving comparable values to those obtained previously using similar protein preparations that had been covalently immobilized within HPAC columns. Zonal elution competition studies with gliclazide were next performed to examine the specific interactions of this drug at Sudlow sites I and II of the adsorbed proteins. These results were also comparable to those noted in prior work with covalently immobilized samples of normal HSA or glycated HSA. These experiments indicated that drug-protein binding studies can be carried out by using on-line immunoextraction microcolumns with HPAC. The same method could be used in the future with clinical samples and other drugs or proteins of interest in pharmaceutical studies or biomedical research.

  5. Laboratory Building.

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Joshua M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    This report is an analysis of the means of egress and life safety requirements for the laboratory building. The building is located at Sandia National Laboratories (SNL) in Albuquerque, NM. The report includes a prescriptive-based analysis as well as a performance-based analysis. Following the analysis are appendices which contain maps of the laboratory building used throughout the analysis. The top of all the maps is assumed to be north.

  6. Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson’s Disease Patients

    OpenAIRE

    Seyed-Mohammad Fereshtehnejad; Hasti Hadizadeh; Farzaneh Farhadi; Gholam Ali Shahidi; Ahmad Delbari; Johan Lökk

    2014-01-01

    The impact of Parkinson's disease (PD) on psychological status and quality of life (QoL) may vary depending on age of disease onset. The aim of this study was to compare psychological symptoms and disease-specific QoL between early onset versus the rest of the PD patients. A total number of 140 PD patients with the mean current age of 61.3 (SD = 10.4) yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as “early-onset” (EOPD) group (n = 45), while the ones w...

  7. Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods

    OpenAIRE

    Jansson, Sven-Arne; Heibert-Arnlind, Marianne; Middelveld, Roelinde JM; Bengtsson, Ulf J; Sundqvist, Ann-Charlotte; Kallström-Bengtsson, Ingrid; Marklund, Birgitta; Rentzos, Georgios; Åkerström, Johanna; Östblom, Eva; Dahlén, Sven-Erik; Ahlstedt, Staffan

    2013-01-01

    Background Our aim was to investigate the factors that affect health related quality of life (HRQL) in adult Swedish food allergic patients objectively diagnosed with allergy to at least one of the staple foods cow’s milk, hen’s egg or wheat. The number of foods involved, the type and severity of symptoms, as well as concomitant allergic disorders were assessed. Methods The disease-specific food allergy quality of life questionnaire (FAQLQ-AF), developed within EuroPrevall, was utilized. The ...

  8. Correlations between disease-specific and generic health status questionnaires in patients with advanced COPD: a one-year observational study

    Directory of Open Access Journals (Sweden)

    Wilke Sarah

    2012-08-01

    Full Text Available Abstract Background Longitudinal studies analyzing the correlations between disease-specific and generic health status questionnaires at different time points in patients with advanced COPD are lacking. The aim of this study was to determine whether and to what extent a disease-specific health status questionnaire (Saint George’s Respiratory Questionnaire, SGRQ correlates with generic health status questionnaires (EuroQol-5-Dimensions, EQ-5D; Assessment of Quality of Life instrument, AQoL; Medical Outcomes Study 36-Item Short-Form Health Survey, SF-36 at four different time points in patients with advanced COPD; and to determine the correlation between the changes in these questionnaires during one-year follow-up. Methods Demographic and clinical characteristics were assessed in 105 outpatients with advanced COPD at baseline. Disease-specific health status (SGRQ and generic health status (EQ-5D, AQoL, SF-36 were assessed at baseline, four, eight, and 12 months. Correlations were determined between SGRQ and EQ-5D, AQoL, and SF-36 scores and changes in these scores. Agreement in direction of change was assessed. Results Eighty-four patients (80% completed one-year follow-up and were included for analysis. SGRQ total score and EQ-5D index score, AQoL total score and SF-36 Physical Component Summary measure (SF-36 PCS score were moderately to strongly correlated. The correlation of the changes between the SGRQ total score and EQ-5D index score, AQoL total score, SF-36 PCS, and SF-36 Mental Component Summary measure (SF-36 MCS score were weak or absent. The direction of changes in SGRQ total scores agreed slightly with the direction of changes in EQ-5D index score, AQoL total score, and SF-36 PCS score. Conclusions At four, eight and 12 months after baseline, SGRQ total scores and EQ-5D index scores, AQoL total scores and SF-36 PCS scores were moderately to strongly correlated, while SGRQ total scores were weakly correlated with SF-36 MCS scores

  9. A method for measuring disease-specific iduronic acid from the non-reducing end of glycosaminoglycan in mucopolysaccharidosis type II mice.

    Science.gov (United States)

    Shimada, Yohta; Wakabayashi, Taichi; Akiyama, Kazumasa; Hoshina, Hiroo; Higuchi, Takashi; Kobayashi, Hiroshi; Eto, Yoshikatsu; Ida, Hiroyuki; Ohashi, Toya

    2016-02-01

    Mucopolysaccharidosis type II (MPS II) is an X-linked lysosomal storage disorder arising from deficiency of iduronate-2-sulfatase (IDS), which results in progressive accumulation of glycosaminoglycans (GAGs) in multiple tissues. Accumulated GAGs are generally measured as the amount of total GAGs. However, we recently demonstrated that GAG accumulation in the brain of MPS II model mice cannot be reliably detected by conventional dye-binding assay measuring total GAGs. Here we developed a novel quantitative method for measurement of disease-specific GAGs based on the analysis of 2-sulfoiduronic acid levels derived from the non-reducing terminal end of the polysaccharides by using recombinant human IDS (rhIDS) and recombinant human iduronidase (rhIDUA). This method was evaluated on GAGs obtained from the liver and brain of MPS II mice. The GAGs were purified from tissue homogenates and then digested with rhIDS and rhIDUA to generate a desulfated iduronic acid from their non-reducing terminal end. HPLC analysis revealed that the generated iduronic acid levels were markedly increased in the liver and cerebrum of the MPS II mice, whereas the uronic acid was not detected in wild-type mice. These results indicate that this assay clearly detects the disease-specific GAGs in tissues from MPS II mice. PMID:26051019

  10. Agreement between a generic and disease-specific quality-of-life instrument: the 15D and the SGRQ in asthmatic patients.

    Science.gov (United States)

    Ritva, K; Pekka, R; Harri, S

    2000-01-01

    The generic health-related quality of life (HRQOL) instrument 15D, and the disease-specific St. George's Respiratory Questionnaire (SGRQ) were highly correlated in cross-sectional and in follow-up data among asthmatic patients. However, a high correlation does not mean that these instruments yield similar results about outcome. We measured among 134 asthmatic patients the mathematical relationship between the changes in the scores of these instruments by regression techniques and agreement by cross-tabulation. The prospective data included measurements at baseline and at one, three and five years. The three measurements of change in HRQOL were compared with the baseline. There was a close mathematical relationship between the scores, but it was affected significantly by confounding factors such as patient's age, gender and smoking habits. The instruments agreed on the direction of change in HRQOL (positive or negative) in 64.8% of patients, while in 15.8% the changes were in opposite direction. There was a statistically significant difference in indicating the direction of changes (improvement or decline) of these instruments. The changes in the SGRQ scores agreed slightly better than those in the 15D with the changes in clinical parameters. The conclusion was that these instruments do not necessarily yield similar results of effectiveness. Therefore, the choice of HRQOL instrument may influence the economic attractiveness of different asthma interventions. The disease-specific SGRQ agreed slightly better than the generic 15D with the changes in clinical parameters. PMID:11332228

  11. Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI with a Generic (SF-36 Instrument

    Directory of Open Access Journals (Sweden)

    Nicole von Steinbuechel

    2016-01-01

    Full Text Available Psychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI, potentially impacting health-related quality of life (HRQoL. Until now, however, neither the discriminatory power of disease-specific (QOLIBRI and generic (SF-36 HRQoL nor their correlates have been compared in detail. These aspects as well as some psychometric item characteristics were studied in a sample of 795 TBI survivors. The Shannon H' index absolute informativity, as an indicator of an instrument’s power to differentiate between individuals within a specific group or health state, was investigated. Psychometric performance of the two instruments was predominantly good, generally higher, and more homogenous for the QOLIBRI than for the SF-36 subscales. Notably, the SF-36 “Role Physical,” “Role Emotional,” and “Social Functioning” subscales showed less satisfactory discriminatory power than all other dimensions or the sum scores of both instruments. The absolute informativity of disease-specific as well as generic HRQoL instruments concerning the different groups defined by different correlates differed significantly. When the focus is on how a certain subscale or sum score differentiates between individuals in one specific dimension/health state, the QOLIBRI can be recommended as the preferable instrument.

  12. Building Inclusion

    NARCIS (Netherlands)

    Jeanet Kullberg; Isik Kulu-Glasgow

    2009-01-01

    The social inclusion of immigrants and ethnic minorities is a central issue in many European countries. Governments face challenges in ensuring housing for immigrants, delivering public services, promoting neighbourhood coexistence and addressing residential segregation. The Building Inclusion proje

  13. Building Languages

    Science.gov (United States)

    ... family's native language) is taught as the child's second language through reading, writing, speech, and use of residual ... that parents can use to help their child learn language. There are many types of building blocks, and ...

  14. Analysis of multi-site drug-protein interactions by high-performance affinity chromatography: Binding by glimepiride to normal or glycated human serum albumin.

    Science.gov (United States)

    Matsuda, Ryan; Li, Zhao; Zheng, Xiwei; Hage, David S

    2015-08-21

    High-performance affinity chromatography (HPAC) was used in a variety of formats to examine multi-site interactions between glimepiride, a third-generation sulfonylurea drug, and normal or in vitro glycated forms of the transport protein human serum albumin (HSA). Frontal analysis revealed that glimepiride interacts with normal HSA and glycated HSA at a group of high affinity sites (association equilibrium constant, or Ka, 9.2-11.8×10(5)M(-1) at pH 7.4 and 37°C) and a group of lower affinity regions (Ka, 5.9-16×10(3)M(-1)). Zonal elution competition studies were designed and carried out in both normal- and reversed-role formats to investigate the binding by this drug at specific sites. These experiments indicated that glimepiride was interacting at both Sudlow sites I and II. Allosteric effects were also noted with R-warfarin at Sudlow site I and with tamoxifen at the tamoxifen site on HSA. The binding at Sudlow site I had a 2.1- to 2.3-fold increase in affinity in going from normal HSA to the glycated samples of HSA. There was no significant change in the affinity for glimepiride at Sudlow site II in going from normal HSA to a moderately glycated sample of HSA, but a slight decrease in affinity was seen in going to a more highly glycated HSA sample. These results demonstrated how various HPAC-based methods can be used to profile and characterize multi-site binding by a drug such as glimepiride to a protein and its modified forms. The information obtained from this study should be useful in providing a better understanding of how drug-protein binding may be affected by glycation and of how separation and analysis methods based on HPAC can be employed to study systems with complex interactions or that involve modified proteins. PMID:26189669

  15. Detection of disease-specific restriction fragment length polymorphisms in pemphigus vulgaris linked to the DQwl and DQw3 alleles of the HLA-D region

    International Nuclear Information System (INIS)

    Pemphigus vulgaris in Israeli Ashkenazi and non-Ashkenazi Jews and in Austrian non-Jewish patients is strongly associated with the DR4 and DRw6 alleles of the HLA-D region class II genes. Restriction fragment length polymorphism analysis was undertaken with DQβ, DQα, and DRβ cDNA probes. Hybridization with the DQβ probe identifies Pvu II, BamHI, and EcoRV fragments that absolutely discriminate pemphigus vulgaris patients from healthy DR-, DQ-, and ethnic-matched controls. In contrast the DQα and DRβ probes failed to identify disease-specific restriction fragment length polymorphism fragments. These studies indicate that DQw1 and DQw3 polymorphisms carried by pemphigus vulgaris patients may be directly involved in predisposition to the disease or may be tightly linked to the susceptibility gene itself. To our knowledge, this is the first example of an HLA restriction fragment length polymorphism that is highly associated with susceptibility to autoimmune disease

  16. Impact of Preoperative Radiotherapy on General and Disease-Specific Health Status of Rectal Cancer Survivors: A Population-Based Study

    International Nuclear Information System (INIS)

    Purpose: To date, few studies have evaluated the impact of preoperative radiotherapy (pRT) on long-term health status of rectal cancer survivors. Using a population-based sample, we assessed the impact of pRT on general and disease-specific health status of rectal cancer survivors up to 10 years postdiagnosis. The health status of older (≥75 years old at diagnosis) pRT survivors was also compared with that of younger survivors. Methods and Materials: Survivors identified from the Eindhoven Cancer Registry treated with surgery only (SU) or with pRT between 1998 and 2007 were included. Survivors completed the Short Form-36 (SF-36) health survey questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal 38 (EORTC QLQ-CR38) questionnaire. The SF-36 and EORTC QLQ-CR38 (sexuality subscale) scores of the survivors were compared to an age- and sex-matched Dutch normal population. Results: A total of 340 survivors (response, 85%; pRT survivors, 71%) were analyzed. Overall, survivors had similar general health status. Both short-term (<5 years) and long-term (≥5 years) pRT survivors had significantly poorer body image and more problems with gastrointestinal function, male sexual dysfunction, and defecation than SU survivors. Survivors had comparable general health status but greater sexual dysfunction than the normal population. Older pRT survivors had general and disease-specific health status comparable to that of younger pRT survivors. Conclusions: For better survivorship care, rectal cancer survivors could benefit from increased clinical and psychological focus on the possible long-term morbidity of treatment and its effects on health status.

  17. Competence Building

    DEFF Research Database (Denmark)

    Borrás, Susana; Edquist, Charles

    The main question that guides this paper is how governments are focusing (and must focus) on competence building (education and training) when designing and implementing innovation policies. With this approach, the paper aims at filling the gap between the existing literature on competences...... on the one hand, and the real world of innovation policy-making on the other, typically not speaking to each other. With this purpose in mind, this paper discusses the role of competences and competence-building in the innovation process from a perspective of innovation systems; it examines how governments...... and public agencies in different countries and different times have actually approached the issue of building, maintaining and using competences in their innovation systems; it examines what are the critical and most important issues at stake from the point of view of innovation policy, looking particularly...

  18. Building Procurement

    DEFF Research Database (Denmark)

    Andersson, Niclas

    2007-01-01

    ‘The procurement of construction work is complex, and a successful outcome frequently elusive’. With this opening phrase of the book, the authors take on the challenging job of explaining the complexity of building procurement. Even though building procurement systems are, and will remain, complex...... despite this excellent book, the knowledge, expertise, well-articulated argument and collection of recent research efforts that are provided by the three authors will help to make project success less elusive. The book constitutes a thorough and comprehensive investigation of building procurement, which...... evolves from a simple establishment of a contractual relationship to a central and strategic part of construction. The authors relate to cultural, ethical and social and behavioural sciences as the fundamental basis for analysis and understanding of the complexity and dynamics of the procurement system...

  19. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...... in the Media”, “Audience Interactivity and Participation”, “The Role of Media and ICT Use for Evolving Social Relationships” and “Audience Transformations and Social Integration”. Building Bridges is the result of an ongoing dialogue between the Action and non-academic stakeholders in the field of audience...

  20. Building Bridges

    DEFF Research Database (Denmark)

    The report Building Bridges adresses the questions why, how and for whom academic audience research has public value, from the different points of view of the four working groups in the COST Action IS0906 Transforming Audiences, Transforming Societies – “New Media Genres, Media Literacy and Trust...

  1. Sustainable Buildings

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Elle, Morten

    The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems...

  2. Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines.

    Directory of Open Access Journals (Sweden)

    Montiago X LaBute

    Full Text Available Late-stage or post-market identification of adverse drug reactions (ADRs is a significant public health issue and a source of major economic liability for drug development. Thus, reliable in silico screening of drug candidates for possible ADRs would be advantageous. In this work, we introduce a computational approach that predicts ADRs by combining the results of molecular docking and leverages known ADR information from DrugBank and SIDER. We employed a recently parallelized version of AutoDock Vina (VinaLC to dock 906 small molecule drugs to a virtual panel of 409 DrugBank protein targets. L1-regularized logistic regression models were trained on the resulting docking scores of a 560 compound subset from the initial 906 compounds to predict 85 side effects, grouped into 10 ADR phenotype groups. Only 21% (87 out of 409 of the drug-protein binding features involve known targets of the drug subset, providing a significant probe of off-target effects. As a control, associations of this drug subset with the 555 annotated targets of these compounds, as reported in DrugBank, were used as features to train a separate group of models. The Vina off-target models and the DrugBank on-target models yielded comparable median area-under-the-receiver-operating-characteristic-curves (AUCs during 10-fold cross-validation (0.60-0.69 and 0.61-0.74, respectively. Evidence was found in the PubMed literature to support several putative ADR-protein associations identified by our analysis. Among them, several associations between neoplasm-related ADRs and known tumor suppressor and tumor invasiveness marker proteins were found. A dual role for interstitial collagenase in both neoplasms and aneurysm formation was also identified. These associations all involve off-target proteins and could not have been found using available drug/on-target interaction data. This study illustrates a path forward to comprehensive ADR virtual screening that can potentially scale with

  3. Building Letters

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Cabinet是种十分吸引人却很简单的衬线字体,是由一名匿名字体设计师专门为Building Letters最新的资金筹集活动所设计的。这个Building Letters包中包含一个CDROM,有32种字体,以及一本专门设计的杂志和两张由Eboy和Emigre所设计的海报。字体光盘样例是由世界顶级的字体设计师们设计的.

  4. Model Building

    OpenAIRE

    Frampton, Paul H.

    1997-01-01

    In this talk I begin with some general discussion of model building in particle theory, emphasizing the need for motivation and testability. Three illustrative examples are then described. The first is the Left-Right model which provides an explanation for the chirality of quarks and leptons. The second is the 331-model which offers a first step to understanding the three generations of quarks and leptons. Third and last is the SU(15) model which can accommodate the light leptoquarks possibly...

  5. Building economics

    DEFF Research Database (Denmark)

    Pedersen, D.O.(red.)

    Publikationen er på engelsk. Den omfatter alle indlæg på det fjerde internationale symposium om byggeøkonomi, der blev arrangeret af SBI for det internationale byggeforskningsråd CIB. De fem bind omhandler: Methods of Economic Evaluation, Design Optimization, Ressource Utilization, The Building...... Market og Economics and Technological Forecasting in Construction. Et indledende bind bringer statusrapporter for de fem forskningsområder, og det sidste bind sammenfatter debatten på symposiet....

  6. High-level activities of daily living and disease-specific mortality during a 12-year follow-up of an octogenarian population

    Directory of Open Access Journals (Sweden)

    Takata Y

    2013-06-01

    Full Text Available Yutaka Takata,1 Toshihiro Ansai,2 Inho Soh,2 Shuji Awano,2 Ikuo Nakamichi,1 Sumio Akifusa,3 Kenichi Goto,1 Akihiro Yoshida,2 Hiroki Fujii,1 Ritsuko Fujisawa,1 Kazuo Sonoki31Division of General Internal Medicine, 2Division of Community Oral Health Science, 3Department of Oral Health and Environment, School of Oral Health Science, Kyushu Dental University, Kitakyushu, JapanBackground: Little is known about the relationship between disease-specific mortality and high-level activities of daily living in the elderly. We examined whether mortality is associated with high-level activities of daily living in an octogenarian population.Methods: We conducted a population-based cross-sectional and prospective cohort study in 693 older persons aged 80 years and living in Japan’s Fukuoka Prefecture. We then evaluated the association between 12-year disease-specific mortality and high-level functional capacity as measured by the Tokyo Metropolitan Institute of Gerontology Index of Competence, which is a standardized multidimensional 13-item instrument; items 1 through 5 are classified as instrumental self-maintenance activity, items 6 through 9 as intellectual activity, items 10 through 13 as social roles activity, and all 13 items together yield total functional capacity.Results: By the 12-year follow-up of the 693 participants, 413 had died, 242 survived, and 38 were unable to be located. Of the 413 who died, 105 died of cardiovascular disease, 73 of respiratory tract disease, 71 of cancer, and 39 of senility. Of the other 125 deaths, 59 were due to other diseases, and the cause of death for 66 participants is not known. The hazard ratio (HR for all-cause mortality, adjusted for confounding factors with multivariate Cox analyses, fell by 6% (HR 0.937, 95% confidence interval [CI] 0.899–0.978, P = 0.003 with each one-point increase in participants’ scores on the Tokyo Metropolitan Institute of Gerontology Index of total functional capacity. With one

  7. Validation study of the prototype of a disease-specific index measure for health-related quality of life in dementia

    Directory of Open Access Journals (Sweden)

    Schölzel-Dorenbos Carla J M

    2012-09-01

    Full Text Available Abstract Background Index measures for health-related quality of life (HRQoL quantify the desirability (utility of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific index measures on the other hand combine disease-specificity and quantification of perceived quality on several health domains of a certain disease into one single figure. These instruments have been developed for several diseases, but a dementia-specific HRQoL index instrument was not yet available. Facing the increasing individual and societal burden of dementia, specific HRQoL values with metric characteristics are especially useful because they will provide vital information for health outcome research and economic evaluations. Aims of the study To develop and validate the prototype of a dementia-specific HRQoL index measure: Dementia Quality of life Instrument (DQI, as the first step towards valuation of the dementia health state. Methods For development of the DQI we created a conceptual framework based on a review of the literature, qualitative interviews with people with dementia and their carers, expert opinion and team discussion. To assess validity we undertook a survey under 241 dementia professionals. Measurements consisted of ranking (1–5 and rating (1–10 of 5 dementia-specific DQI domains (memory, orientation, independence, social activities and mood and simultaneously rating of 9 DQI-derived health states on a visual analogue scale (VAS. We also performed a cross-sectional study in a large sample of people with very mild to moderate dementia and their caregivers (N = 145 to assess feasibility and concurrent validity. In addition, caregivers valued 10 DQI and 10 EQ-5D + C derived health states of the patient simultaneously on the same VAS. Setting: outpatient clinics, nursing homes and patient residences. Results All

  8. Validation and reliability of a disease-specific quality of life measure (the TranQol) in adults and children with thalassaemia major.

    Science.gov (United States)

    Klaassen, Robert J; Barrowman, Nicholas; Merelles-Pulcini, Manuela; Vichinsky, Elliott P; Sweeters, Nancy; Kirby-Allen, Melanie; Neufeld, Ellis J; Kwiatkowski, Janet L; Wu, John; Vickars, Linda; Blanchette, Victor S; Forgie, Melissa; Yamashita, Robert; Wong-Rieger, Durhane; Young, Nancy L

    2014-02-01

    This study aimed to demonstrate the validity, reliability and responsiveness of a new disease-specific quality of life (QoL) questionnaire for children and adults with thalassaemia major, the Transfusion-dependent QoL questionnaire (TranQol). 106 participants (51 adults and 55 children) were recruited from six North American thalassaemia treatment centres with a mean age of 20·7 years (standard deviation [SD] 9, range 7-51 years). The mean total TranQol score was 71 (SD 17, 32-97) on a scale of 0-100. Patients with co-morbidities had significantly lower scores (63 vs. 75, P = 0·001). TranQol scores showed substantial agreement (P < 0·001) with the Health Utilities Index Mark 3 (all patients, r = 0·65), the Pediatric QoL (children, r = 0·77) and the Short Form (36) physical (adults, r = 0·69) and mental summary scores (r = 0·76). In the subgroup who rated their QoL as better, there was a 4·0 point (SD 9·0) improvement in TranQol scores, from baseline of 67·1-71·1 one week later (P = 0·008). Test-retest reliability was excellent (intra-class correlation coefficient, 0·93). The TranQol was valid, with acceptable correlation for all administered measures and was reliable and responsive to change. The TranQol can be incorporated into future studies of thalassaemia major.

  9. Validation of the memorial Sloan-Kettering Cancer Center nomogram to predict disease-specific survival after R0 resection in a Chinese gastric cancer population.

    Directory of Open Access Journals (Sweden)

    Donglai Chen

    Full Text Available BACKGROUND: Prediction of disease-specific survival (DSS for individual patient with gastric cancer after R0 resection remains a clinical concern. Since the clinicopathologic characteristics of gastric cancer vary widely between China and western countries, this study is to evaluate a nomogram from Memorial Sloan-Kettering Cancer Center (MSKCC for predicting the probability of DSS in patients with gastric cancer from a Chinese cohort. METHODS: From 1998 to 2007, clinical data of 979 patients with gastric cancer who underwent R0 resection were retrospectively collected from Peking University Cancer Hospital & Institute and used for external validation. The performance of the MSKCC nomogram in our population was assessed using concordance index (C-index and calibration plot. RESULTS: The C-index for the MSKCC predictive nomogram was 0.74 in the Chinese cohort, compared with 0.69 for American Joint Committee on Cancer (AJCC staging system (P<0.0001. This suggests that the discriminating value of MSKCC nomogram is superior to AJCC staging system for prognostic prediction in the Chinese population. Calibration plots showed that the actual survival of Chinese patients corresponded closely to the MSKCC nonogram-predicted survival probabilities. Moreover, MSKCC nomogram predictions demonstrated the heterogeneity of survival in stage IIA/IIB/IIIA/IIIB disease of the Chinese patients. CONCLUSION: In this study, we externally validated MSKCC nomogram for predicting the probability of 5- and 9-year DSS after R0 resection for gastric cancer in a Chinese population. The MSKCC nomogram performed well with good discrimination and calibration. The MSKCC nomogram improved individualized predictions of survival, and may assist Chinese clinicians and patients in individual follow-up scheduling, and decision making with regard to various treatment options.

  10. Evidence for validity of a national physician and patient-reported, cross-sectional survey in China and UK: the Disease Specific Programme

    Science.gov (United States)

    Babineaux, S M; Curtis, B; Holbrook, T; Milligan, G; Piercy, J

    2016-01-01

    Objective Diabetes represents a significant challenge for Chinese healthcare providers. Healthcare decision-making is generally based on many data sources, including randomised controlled and real-world studies; however, good-quality data from Chinese diabetes patients are scarce. We performed an initial validation to assess the representativeness of one source of real-world data—the Diabetes Adelphi Disease Specific Programme (DSP) in China. Setting China, UK. Participants The Chinese DSP included 2060 patients with previously diagnosed type 2 diabetes mellitus (T2DM) sampled by 200 physicians. The reference Chinese population comprised 238 639 patients with previously diagnosed T2DM. The UK DSP contained 1481 patients with T2DM sampled by 125 physicians; the reference UK population comprised 289 patients with diabetes. Primary and secondary outcomes The primary outcome was comparison of unweighted China DSP and reference data for sex, body mass index (BMI), blood pressure (BP), patients achieving glycosylated haemoglobin (HbA1c)HbA1c, total cholesterol, smoking and insulin status. Results Comparison of unweighted China DSP and reference data revealed statistical equivalence for BMI, systolic BP, proportion of patients achieving HbA1c HbA1c level were not equivalent, although differences were generally small. Weighting of data did not substantially affect the results. A similar pattern was observed for UK data. Conclusions This study provides evidence that the methodology used for the China and UK parts of the Diabetes DSP produces representative samples that are comparable with other independent sources of patient treatment outcomes data, which may ultimately inform public health decision-making. Although this method could be used in other countries, the current validation applies to UK and China. Further research is required for other countries. PMID:27531722

  11. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Kenichi eOishi

    2011-08-01

    Full Text Available Background: Alterations of the gray and white matter have been identified in Alzheimer’s disease (AD by structural MRI and diffusion tensor imaging (DTI. However, whether the combination of these modalities could increase the diagnostic performance is unknown.Methods: Participants included 19 AD patients, 22 amnestic mild cognitive impairment (aMCI patients, and 22 cognitively normal elderly (NC. The aMCI group was further divided into an aMCI-converter group (converted to AD dementia within three years, and an aMCI-stable group who did not convert in this time period. A T1-weighted image, a T2 map, and a DTI of each participant were normalized, and voxel-based comparisons between AD and NC groups were performed. Regions-of-interest, which defined the areas with significant differences between AD and NC, were created for each modality and named disease-specific spatial filters (DSF. Linear discriminant analysis was used to optimize the combination of multiple MRI measurements extracted by DSF to effectively differentiate AD from NC. The resultant DSF and the discriminant function were applied to the aMCI group to investigate the power to differentiate the aMCI-converters from the aMCI-stable patients. Results: The multi-modal approach with AD-specific filters led to a predictive model with an area under the receiver operating characteristic curve (AUC of 0.93, in differentiating aMCI-converters from aMCI-stable patients. This AUC was better than that of a single-contrast-based approach, such as T1-based morphometry or diffusion anisotropy analysis. Conclusion: The multi-modal approach has the potential to increase the value of MRI in predicting conversion from aMCI to AD.

  12. The role of personality in the course of health-related quality of life and disease-specific health status among colorectal cancer survivors: A prospective population-based study from the PROFILES registry

    NARCIS (Netherlands)

    Husson, O.; Vissers, P.A.; Denollet, J.; Mols, F.

    2015-01-01

    BACKGROUND: Prospective studies in various cardiovascular populations show that Type D personality predicted impaired health-related quality of life (HRQoL) and disease-specific health status. We examined the effect of negative affectivity (NA), social inhibition (SI) and their combined effect (Type

  13. Can a disease-specific education program augment self-management skills and improve Health-Related Quality of Life in people with hip or knee osteoarthritis?

    Directory of Open Access Journals (Sweden)

    Buchbinder Rachelle

    2006-11-01

    Full Text Available Abstract Background Patient education and self-management programs are offered in many countries to people with chronic conditions such as osteoarthritis (OA. The most well-known is the disease-specific Stanford Arthritis Self-Management Program (ASMP. While Australian and international clinical guidelines promote the concept of self-management for OA, there is currently little evidence to support the use of the ASMP. Several meta-analyses have reported that arthritis self-management programs had minimal or no effect on reducing pain and disability. However, previous studies have had methodological shortcomings including the use of outcome measures which do not accurately reflect program goals. Additionally, limited cost-effectiveness analyses have been undertaken and the cost-utility of the program has not been explored. Methods/design This study is a randomised controlled trial to determine the efficacy (in terms of Health-Related Quality of Life and self-management skills and cost-utility of a 6-week group-based Stanford ASMP for people with hip or knee OA. Six hundred participants referred to an orthopaedic surgeon or rheumatologist for hip or knee OA will be recruited from outpatient clinics at 2 public hospitals and community-based private practices within 2 private hospital settings in Victoria, Australia. Participants must be 18 years or over, fluent in English and able to attend ASMP sessions. Exclusion criteria include cognitive dysfunction, previous participation in self-management programs and placement on a waiting list for joint replacement surgery or scheduled joint replacement. Eligible, consenting participants will be randomised to an intervention group (who receive the ASMP and an arthritis self-management book or a control group (who receive the book only. Follow-up will be at 6 weeks, 3 months and 12 months using standardised self-report measures. The primary outcome is Health-Related Quality of Life at 12 months, measured

  14. A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: Its development and validation

    Directory of Open Access Journals (Sweden)

    McMillan Robert

    2007-02-01

    Full Text Available Abstract Background No validated disease-specific measures are available to assess health-related quality of life (HRQoL in adult subjects with immune thrombocytopenic purpura (ITP. Therefore, we sought to develop and validate the ITP-Patient Assessment Questionnaire (ITP-PAQ for adult subjects with ITP. Methods Information from literature reviews, focus groups with subjects, and clinicians were used to develop 50 ITP-PAQ items. Factor analyses were conducted to develop the scale structure and reduce the number of items. The final 44-item ITP-PAQ, which includes ten scales [Symptoms (S, Bother-Physical Health (B, Fatigue/Sleep (FT, Activity (A, Fear (FR, Psychological Health (PH, Work (W, Social Activity (SA, Women's Reproductive Health (RH, and Overall (QoL], was self-administered to adult ITP subjects at baseline and 7–10 days later. Test-retest reliability, internal consistency reliability, construct and known groups validity of the final ITP-PAQ were evaluated. Results Seventy-three subjects with ITP completed the questionnaire twice. Test-retest reliability, as measured by the intra-class correlation, ranged from 0.52–0.90. Internal consistency reliability was demonstrated with Cronbach's alpha for all scales above the acceptable level of 0.70 (range: 0.71–0.92, except for RH (0.66. Construct validity, assessed by correlating ITP-PAQ scales with established measures (Short Form-36 v.1, SF-36 and Center for Epidemiologic Studies Depression Scale, CES-D, was demonstrated through moderate correlations between the ITP-PAQ SA and SF-36 Social Function scales (r = 0.67, and between ITP-PAQ PH and SF-36 Mental Health Scales (r = 0.63. Moderate to strong inter-scale correlations were reported between ITP-PAQ scales and the CES-D, except for the RH scale. Known groups validity was evaluated by comparing mean scores for groups that differed clinically. Statistically significant differences (p Conclusion Results provide preliminary evidence of

  15. Building energy analysis tool

    Science.gov (United States)

    Brackney, Larry; Parker, Andrew; Long, Nicholas; Metzger, Ian; Dean, Jesse; Lisell, Lars

    2016-04-12

    A building energy analysis system includes a building component library configured to store a plurality of building components, a modeling tool configured to access the building component library and create a building model of a building under analysis using building spatial data and using selected building components of the plurality of building components stored in the building component library, a building analysis engine configured to operate the building model and generate a baseline energy model of the building under analysis and further configured to apply one or more energy conservation measures to the baseline energy model in order to generate one or more corresponding optimized energy models, and a recommendation tool configured to assess the one or more optimized energy models against the baseline energy model and generate recommendations for substitute building components or modifications.

  16. Building America

    Energy Technology Data Exchange (ETDEWEB)

    Brad Oberg

    2010-12-31

    Builders generally use a 'spec and purchase' business management system (BMS) when implementing energy efficiency. A BMS is the overall operational and organizational systems and strategies that a builder uses to set up and run its company. This type of BMS treats building performance as a simple technology swap (e.g. a tank water heater to a tankless water heater) and typically compartmentalizes energy efficiency within one or two groups in the organization (e.g. purchasing and construction). While certain tools, such as details, checklists, and scopes of work, can assist builders in managing the quality of the construction of higher performance homes, they do nothing to address the underlying operational strategies and issues related to change management that builders face when they make high performance homes a core part of their mission. To achieve the systems integration necessary for attaining 40% + levels of energy efficiency, while capturing the cost tradeoffs, builders must use a 'systems approach' BMS, rather than a 'spec and purchase' BMS. The following attributes are inherent in a systems approach BMS; they are also generally seen in quality management systems (QMS), such as the National Housing Quality Certification program: Cultural and corporate alignment, Clear intent for quality and performance, Increased collaboration across internal and external teams, Better communication practices and systems, Disciplined approach to quality control, Measurement and verification of performance, Continuous feedback and improvement, and Whole house integrated design and specification.

  17. Building trust

    International Nuclear Information System (INIS)

    'Activate' is the energy magazine for secondary schools and is part of the Education Programme which is managed on behalf of the British Nuclear Industry Forum by AEA Technology. activate is the flagship communication device between the British Nuclear Industry Forum's Education Programme and secondary schools in the UK. It was developed from a previous publication, Nuclear Bulletin. There is a need for the nuclear industry to build trust with teachers and students in the UK, where for a long time, everything that the industry has said, written or printed has been disregarded by school teachers as propaganda. Over the last few years the industry has put in a great deal of effort to position itself as a provider of educationally sound and socially acceptable information. 'Activate' was an evolution of this idea and there was a hole in the market for a lively, activity and article based magazine that could be used in the classroom. The target audience is principally teachers of science, mathematics and geography, but also includes teachers of art,, English and history with students of between 11 and 18. The results were very positive in that teachers appreciated the colourful and lively nature of activate and they felt that it provided information and opinions in an un biased and non-propagandist way. Their comments about layout, number of activities style of presentation were taken into account and during the summer of 1994 activate was remodelled ready for re launch in September. The feedback so far is good with more teachers signing up every week to receive their own free copy

  18. BUILDING 341 Seismic Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Halle, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-06-15

    The Seismic Evaluation of Building 341 located at Lawrence Livermore National Laboratory in Livermore, California has been completed. The subject building consists of a main building, Increment 1, and two smaller additions; Increments 2 and 3.

  19. Danish building typologies

    DEFF Research Database (Denmark)

    Wittchen, Kim Bjarne; Kragh, Jesper

    The objective of TABULA is to develop a harmonised building typology for European countries. Each national building typology will consist of a set of residential model buildings with characteristic energy-related properties (element areas of the thermal building envelope, U-values, supply system...... efficiencies). The model buildings will each represent a specific construction period of the country in question and a specific building size. Furthermore the number of buildings, flats and the overall floor areas will be given, which are represented by the different building types of the national typologies....

  20. Integrating Responsive Building Elements in Buildings

    DEFF Research Database (Denmark)

    Haase, Matthias; Amato, Alex; Heiselberg, Per

    2006-01-01

    energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work and discusses its usefulness for Hong Kong and China. Special focus was put......There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...

  1. Comparison of efficacy of the disease-specific LOX1- and constitutive cytomegalovirus-promoters in expressing interleukin 10 through adeno-associated virus 2/8 delivery in atherosclerotic mice.

    Directory of Open Access Journals (Sweden)

    Hongqing Zhu

    Full Text Available The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of "disease-specific promoters" has strong appeal. Many therapeutic genes, including transforming growth factor beta 1 or interleukin 10, are associated to adverse effects. The use of a disease-specific promoter might minimize toxicity. The lectin-like oxidized low density lipoprotein receptor 1 is a marker of cardiovascular disease and a potential therapeutic target. The lectin-like oxidized low density lipoprotein receptor 1 is known to be up-regulated early during disease onset in a number of cell types at the sites where the disease will be clinically evident. In this study an adeno-associated virus-2 DNA vector (AAV2 using the AAV8 capsid, and containing the full length The lectin-like oxidized low density lipoprotein receptor 1 promoter, was generated and assayed for its ability to express human interleukin 10 in low density lipoprotein receptor knockout mice on high cholesterol diet. The cytomegalovirus early promoter was used for comparison in a similarly structured vector. The two promoters were found to have equal efficacy in reducing atherogenesis as measured by aortic systolic blood velocity, aortic cross sectional area, and aortic wall thickness. This is the first head-to-head comparison of a constitutive with a disease-specific promoter in a therapeutic context. These data strongly suggest that the use of a disease-specific promoter is appropriate for therapeutic gene delivery.

  2. Comparison of Efficacy of the Disease-Specific LOX1- and Constitutive Cytomegalovirus-Promoters in Expressing Interleukin 10 through Adeno-Associated Virus 2/8 Delivery in Atherosclerotic Mice

    Science.gov (United States)

    Zhu, Hongqing; Cao, Maohua; Mirandola, Leonardo; Figueroa, Jose A.; Cobos, Everardo; Chiriva-Internati, Maurizio; Hermonat, Paul L.

    2014-01-01

    The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of “disease-specific promoters” has strong appeal. Many therapeutic genes, including transforming growth factor beta 1 or interleukin 10, are associated to adverse effects. The use of a disease-specific promoter might minimize toxicity. The lectin-like oxidized low density lipoprotein receptor 1 is a marker of cardiovascular disease and a potential therapeutic target. The lectin-like oxidized low density lipoprotein receptor 1 is known to be up-regulated early during disease onset in a number of cell types at the sites where the disease will be clinically evident. In this study an adeno-associated virus-2 DNA vector (AAV2) using the AAV8 capsid, and containing the full length The lectin-like oxidized low density lipoprotein receptor 1 promoter, was generated and assayed for its ability to express human interleukin 10 in low density lipoprotein receptor knockout mice on high cholesterol diet. The cytomegalovirus early promoter was used for comparison in a similarly structured vector. The two promoters were found to have equal efficacy in reducing atherogenesis as measured by aortic systolic blood velocity, aortic cross sectional area, and aortic wall thickness. This is the first head-to-head comparison of a constitutive with a disease-specific promoter in a therapeutic context. These data strongly suggest that the use of a disease-specific promoter is appropriate for therapeutic gene delivery. PMID:24736312

  3. The Building Commissioning Handbook.

    Science.gov (United States)

    Heinz, John A.; Casault, Rick

    This book discusses building commissioning, which is the process of certifying that a new facility meets the required specifications. As buildings have become more complex, the traditional methods for building start-up and final acceptance have been proven inadequate, and building commissioning has been developed, which often necessitates the use…

  4. Global building physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2013-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or ‘global’, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. This brief article reports the keynote...

  5. Global Building Physics

    DEFF Research Database (Denmark)

    Rode, Carsten

    2012-01-01

    High ambitions are set for the building physics performance of buildings today. No single technology can achieve fulfilment of these ambitions alone. Integrated, multi-facetted solutions and optimization are necessary. A holistic, or “global”, technological perspective is needed, which includes all...... aspects of the building as defined in building engineering. We live in an international society and building solutions are developed across country borders. Building physics is a global theme. The International Association of Building Physics has global appeal. The keynote lecture and this brief paper...

  6. Retrofitting Listed Buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2011-01-01

    The paper presents a case study where the energy demand for a listed building constructed in 1900 is reduced. Many older buildings are listed and have restrictions that include the entire building or that include only its exterior. For the building presented, only its exterior facade is listed...... of the local urban environment and therefore listed. The reduced energy demand, related to individual measures, is estimated and building physics requirements are addressed together with the economic options for evaluating the profitability....

  7. ICT Enhanced Buildings Potentials

    DEFF Research Database (Denmark)

    Christiansson, Per

    2007-01-01

    The paper describes and gives example on how Information and Communication, ICT, can and will enhance and support the building functional systems defined from client and end-user needs and requirements. The building systems may be derived from functional requirements on buildings such as usability...... and security on highest level with sub-systems definitions on lever levels. Building functional sub-systems may be defined for user comfort, indoor-climate, evacuation, space configuration, aesthetics, O&M etc. These building systems are supported by Information and Communication Technology, ICT, and building...... with focus on virtual building models support, new services and user environment definitions and development, virtual spaces and augmented reality, intelligent building components, application ontologies, and ICT systems integration to illustrate ICT enhanced buildings potentials and R&D needs.  ...

  8. Sustainable Buildings in Interaction

    DEFF Research Database (Denmark)

    Elle, Morten

    2007-01-01

    The first attempts to build sustainable buildings in Denmark were typically located on the countryside. The basic idea was to create buildings that were independent of the technical infrastructure. District heating has, however, been the dominating solution to heating in buildings in Denmark......, and the focus on sustainable building have gradually turned from special houses on the countryside to normally looking houses in the urban fabric, integrated in the technical infrastructure. Some new built urban areas in Denmark will, however, not have to be supplied with district heating – these developments...... are going to consist of passive houses. The first sustainable buildings were built by their users, and the user – building interaction still play a decisive role for the performance of the present sustainable buildings. The users have to understand how the building functions. Urban design is essential...

  9. Applied building physics

    CERN Document Server

    Hens, Hugo S L C

    2012-01-01

    The energy crises of the 1970s, persisting moisture problems, complaints about sick buildings, thermal, visual and olfactory discomfort, and the move towards more sustainability in building construction have pushed Building Physics to the forefront of building innovation. The societal pressure to diminish energy consumption in buildings without impairing usability acted as a trigger to activate the whole notion of performance based design and construction. As with all engineering sciences, Building Physics is oriented towards application, which is why, after a first book on fundamentals this s

  10. Comfort control in buildings

    CERN Document Server

    Castilla, Maria del Mar; Rodriguez, Francisco de Asis

    2014-01-01

    This book describes both concepts and development of advanced comfort control systems in buildings, with significant energy saving, and attention to thermal, visual and indoor air quality. The concepts are proven through real tests in a bioclimatic building.

  11. Building the Korogwe Laboratory

    DEFF Research Database (Denmark)

    Knudsen, Jakob; von Seidlein, Lorenz; Richard, Jean Pierre

    2011-01-01

    An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania.......An illustrated description of the building of a biomedical research laboratory in Korogwe, Tanzania....

  12. Building Design & Construction - Sustainability

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-11-01

    Offers a brief history of green building; presents the results of a specially commissioned survey; and analyzes the chief trends, issues, and published research, based on interviews with dozens of experts and participants in green building.

  13. Robotic buildings(s)

    NARCIS (Netherlands)

    Bier, H.H.

    2014-01-01

    Technological and conceptual advances in fields such as artificial intelligence, robotics, and material science have enabled robotic building to be in the last decade prototypically implemented. In this context, robotic building implies both physically built robotic environments and robotically supp

  14. Better Buildings Challenge Overview

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-06-01

    The Better Buildings Challenge is a national leadership initiative calling on corporate chief executive officers, university presidents, and state and local leaders to make a significant commitment to building energy efficiency.

  15. Requirements for existing buildings

    DEFF Research Database (Denmark)

    Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne

    2012-01-01

    This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....

  16. Integrated Building Health Management

    Data.gov (United States)

    National Aeronautics and Space Administration — Abstract: Building health management is an important part in running an efficient and cost-effective building. Many problems in a building’s system can go...

  17. Allegheny County Building Footprints

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains photogrammetrically compiled roof outlines of buildings. All near orthogonal corners are square. Buildings that are less than 400 square feet...

  18. Buildings interoperability landscape - Draft

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave B. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2015-02-01

    Buildings are an integral part of our nation’s energy economy. The advancement in information and communications technology (ICT) has revolutionized energy management in industrial facilities and large commercial buildings. As ICT costs decrease and capabilities increase, buildings automation and energy management features are transforming the small-medium commercial and residential buildings sectors. A vision of a connected world in which equipment and systems within buildings coordinate with each other to efficiently meet their owners’ and occupants’ needs, and where buildings regularly transact business with other buildings and service providers (such as gas and electric service providers) is emerging. However, while the technology to support this collaboration has been demonstrated at various degrees of maturity, the integration frameworks and ecosystems of products that support the ability to easily install, maintain, and evolve building systems and their equipment components are struggling to nurture the fledging business propositions of their proponents.

  19. Building Materials Property Table

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-04-16

    This information sheet describes a table of some of the key technical properties of many of the most common building materials taken from ASHRAE Fundamentals - 2001, Moisture Control in Buildings, CMHC, NRC/IRC, IEA Annex 24, and manufacturer data.

  20. Building the ISS

    Institute of Scientific and Technical Information of China (English)

    石继忠; 李秀霞

    2007-01-01

    Have you seen people building houses?To build a house,you need workers.They use their hands,tools and machines to put everything together. Building the ISS is almost the same.The difference is that the workers are astronauts.They

  1. Future Green Buildings

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Drysdale, David; Lund, Henrik;

    Efficient buildings are essential for an affordable Danish energy supply in 2050. The purpose of this report is to describe the contribution and role of the building sector in a 100% renewable energy future, as well as the transitions that are necessary in the building sector to support this chan...

  2. Marine Building Technology

    OpenAIRE

    Westby, Ola

    2006-01-01

    This textbook is all about building of ships, platforms and other offshore installations. The geometry and functions of systems and structures are explained as an introduction to management and technology at shipyards and building sites. Both loadbearing structures, outfitting and installation of accommodation are included. Project management, production planning, cost calculations, building methods, discipline knowledge (welding, painting, insulation, mechanical, piping etc.), fabrication te...

  3. Building with History

    DEFF Research Database (Denmark)

    Douglas-Jones, Rachel; Adams, Charlotte; Green, Adrian;

    2014-01-01

    on the thermal and energetic properties of historic buildings, as distinct from their social meaning and use. A similar separation between the physi- cal building and its social use is inherent in methodologies such as energy audits that constitute key devices through which buildings are institution- ally...

  4. Building Order in the Building Company Organization

    OpenAIRE

    Krivdová, Magdaléna

    2013-01-01

    The aim of the thesis is to describe an organization of a building order, and to show its key phases. The individual phases of how a order is completed in a company are shown on practical examples. The first two chapters deal with the current situation of today's construction industry; consequently, the reasons for introducing the principles of project management into the construction business practice are mentioned. The third chapter is devoted to the description of a building order. It...

  5. Controlling the intelligent building

    Energy Technology Data Exchange (ETDEWEB)

    LeBlanc, R.J.

    1985-08-01

    Companies will be able to locate in intelligent buildings that offer access to a variety of sophisticated communications equipment, at the heart of which are building controls that ensure a comfortable and safe working environment for the occupants. Future buildings will include advanced telephones or workstations with built-in building control sensors for temperature, light level, and security. Advanced telecommunication systems may have telephone cabinets with built-in control functions which eliminate the need for discrete control systems. The owners and tenants will both enjoy benefits if the controls are carefully selected and designed so that they integrate into a single building package.

  6. Net zero energy buildings

    Energy Technology Data Exchange (ETDEWEB)

    Nieminen, J., Email: jyri.nieminen@vtt.fi

    2012-06-15

    Two net zero apartment buildings with basically similar architecture have been built in Finland, in Kuopio (latitude 62.90) and in Jaervenpaeae (latitude 60.50). The aim was to test the possibilities to build zero energy buildings at high latitudes. The Kuopio case is a student hostel and the Jaervenpaeae case a home for elderly people. The total energy demand in the buildings are 102 MWh for Kuopio and 94.3 for Jaervenpaeae corresponding to 48 and 45 and kWh/gross-m2. The buildings utilise district heat and are connected to the local grid. The renewable energy production bases in the Kuopio case on solar heat and photovoltaics. The Kuopio building has been finished in 2010 and the Jaervenpaeae building in 2011. (orig.)

  7. Commercial Buildings Characteristics, 1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-29

    Commercial Buildings Characteristics 1992 presents statistics about the number, type, and size of commercial buildings in the United States as well as their energy-related characteristics. These data are collected in the Commercial Buildings Energy Consumption Survey (CBECS), a national survey of buildings in the commercial sector. The 1992 CBECS is the fifth in a series conducted since 1979 by the Energy Information Administration. Approximately 6,600 commercial buildings were surveyed, representing the characteristics and energy consumption of 4.8 million commercial buildings and 67.9 billion square feet of commercial floorspace nationwide. Overall, the amount of commercial floorspace in the United States increased an average of 2.4 percent annually between 1989 and 1992, while the number of commercial buildings increased an average of 2.0 percent annually.

  8. Building for animal production

    International Nuclear Information System (INIS)

    In order to limit the radiation dose to persons working with animal husbandry in severe fallout situations, it was considered necessary to make an inventory of the Swedish livestock buildings as to number, location, use and size. These data as well as data on geometry of buildings, building material and thickness of the material in walls and roofs are given in the present work. On the basis of the mentioned data, calculations were made of the shielding factors of different types of livestock buildings. The collected data can also be used in preparedness planning in relation to housing facilities for livestock and location and size of animal production in situations of crises or war. The calculations show shielding factors for different types of livestock buildings of normal ground area within the range of 0.18-0.71. The higher value indicates a fairly poor shielding effect. The inventory and the calculations show that in those regions in Sweden where the main part of the livestock is managed, the types of buildings are, however, characterized by radiation shielding factors of 0.3-0.4. Calculation were also made of the radiation level inside the buildings following decontamination of roofs or of surrounding ground. Ground decontamination only, i.e., removal of the upper contaminated surface layer, will reduce the radiation level inside the building. For most buildings the radius of the surrounding area to be decontaminated has to be 15-30 times larger than the width of the building in order to achieve a 50 percentage reduction of the radiation level inside the building. For buildings of medium or large size and with thick walls the radiation contribution from the roof is greater than the radiation from the ground, and regardless of the size of the ground areas decontaminated the radiation level inside these buildings will only be reduced by 20-30%. 15 refs, 11 figs, 14 tabs

  9. Building perservation practice

    DEFF Research Database (Denmark)

    Pilegaard, Marie Kirstine

    of architects and planners is primarily to reconcile the conservation prospects with the future use of buildings and sites. They intermediary the site through selections of the narratives, and in practice the restoration or transformation projects becomes a communication of the selected story, utilized...... planning? In this paper I will focus on the communication of the architects working with building preservation and planning, how they communicate the building, the interventions and the storytelling in practice. The methods used by the architects are based on a practice, where some skills are learned...... through education, such as documentation of buildings and the restoration as a way of communicating the architect's intervention on the building, meanwhile the communication of the buildings history is seen as a "natural" skill and the methods are not questioned in the practice. The storytelling has today...

  10. Sustainable Building Operation

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    2009-01-01

    Energy-savings in the existing building stock have becomes a main goal in national and international policies. Often focus is on building-renovations, whereas the potential of sustainable building operation to a large extent has been neglected. Nevertheless, international research as well...... as practical experiences from Danish housing estates indicates that there are large potentials for energy savings by focusing on the operation of the buildings. We suggest that in order to achieve sustainability in the existing housing, renovation and operations should be seen as integrated parts...... building operation as an 'umbrella' for various ways of reducing flows of energy, water and waste in the daily operation of the buildings, for instance by regular monitoring the consumption, by using 'green accounting', by applying policies for sustainability etc. The paper is based on case studies...

  11. Capacity Building in Vietnam

    OpenAIRE

    Adam McCarty

    2001-01-01

    This report is the outcome of a study commissioned to examine the capacity building needs in Vietnam, and is a supplementary document to the Asian Development Bank's Country Operational Strategy for Vietnam. Vietnam's needs in terms of capacity building are particularly important given that is it a transitional economy and also one with little institutional experience in dealing with the international donor community. This paper examines the international awareness of capacity building and ca...

  12. Development of Ecological Buildings

    Directory of Open Access Journals (Sweden)

    Andrius Keizikas

    2011-04-01

    Full Text Available The article presents research on ecological buildings and their influence on the constructional sphere. The aim of the paper is to reveal the essence of ecological architecture showing substantial progress and its potential to stimulate architectural and technological growth. The article also describes relations between the ideas of ecological buildings and the ‘passive house’ concepts and aspects of development as well as describes the possibilities of improving building sustainability and energy efficiency. Article in Lithuanian

  13. Building valve amplifiers

    CERN Document Server

    Jones, Morgan

    2013-01-01

    Building Valve Amplifiers is a unique hands-on guide for anyone working with tube audio equipment--as an electronics hobbyist, audiophile or audio engineer. This 2nd Edition builds on the success of the first with technology and technique revisions throughout and, significantly, a major new self-build project, worked through step-by-step, which puts into practice the principles and techniques introduced throughout the book. Particular attention has been paid to answering questions commonly asked by newcomers to the world of the valve, whether audio enthusiasts tackling their first build or

  14. Healthy Buildings '88

    International Nuclear Information System (INIS)

    The Healthy Buildings '88 Conference focuses on the technical solutions and functional requirements contributing to Healthy Buildings for people to live and work in. The main object of the Conference is to give architects, consultants, real-estate owners and manufacturers of building materials recommendations on choice of materials and choice of systems and on how to combine materials and systems. The program includes overview lectures, plenary symposia with invited speakers, workshops, poster presentations and an exhibition of scientific, educational and technical material. One part of the conference is devoted to the problem of radon in residential buildings

  15. Sick building syndrome

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2002-06-01

    Full Text Available Sick building syndrome describes a number of mostly unspesific complaints of some occupants of the building. The exact pathophysiological mechanism remains elusive. It is a multi factorial event which may include physical, chemical, biological as well as psycological factors. In many cases it is due to insufficient maintenance of the HVAC (heating, ventilation, air conditioning system in the building. Sign and symptoms can be uncomfortable and even disabling, which may include mucus membrane irritation, neurotoxic symptoms, asthma like symptoms, skin complaints, gastrointestinal symptoms and other related symptoms. There are various investigation methods to diagnose sick building syndrome, and on site assessment of the building is extremely useful. Prevention through a proactive air quality monitoring program is far more desirable than dealing with an actual sick building. Indoor air and the sick building symdrome serves as a paradigm of modern occupational and environmental medicine. (Med J Indones 2002; 11:124-31Keywords: indoor air pollution, sick building syndrome, building related illness

  16. Buildings for Education.

    Science.gov (United States)

    Asian Regional Inst. for School Building Research, Colombo (Sri Lanka).

    The quarterly review for October and December 1967 of the Asian Regional Institute for School Building Research at Colombo, Ceylon--(1) reviews two main activities of a cost and space utilization study and a report of the workshop of the directors and UNESCO experts on regional educational buildings, (2) describes a method for determining teacher…

  17. Building a Better Robot

    Science.gov (United States)

    Navah, Jan

    2012-01-01

    Kids love to build robots, letting their imaginations run wild with thoughts of what they might look like and what they could be programmed to do. Yet when students use cereal boxes and found objects to make robots, often the projects look too similar and tend to fall apart. This alternative allows students to "build" robots in a different way,…

  18. Building: Food for thought

    Directory of Open Access Journals (Sweden)

    Efraïm Rodríguez

    2011-05-01

    Full Text Available The sculpture presented by Efraïm Rodríguez for the conference is titled “pequeño arquitecto” (The Little Architect, a figure which represents a child building a tower with pieces of classical children’s block building toys; the child itself is built out of the same sculpted materials.

  19. Building Numbers from Primes

    Science.gov (United States)

    Burkhart, Jerry

    2009-01-01

    Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…

  20. Electromagnetically shielded building

    International Nuclear Information System (INIS)

    This invention relates to a building having an electromagnetic shield structure well-suited for application to an information network system utilizing electromagnetic waves, and more particularly to an electromagnetically shielded building for enhancing the electromagnetic shielding performance of an external wall. 6 figs

  1. School Building Defect Pattern

    Directory of Open Access Journals (Sweden)

    Mahli M.

    2014-01-01

    Full Text Available In providing a conducive learning environment for the student, the school building must be in good condition. This paper is evaluating the existing condition of primary school building in Sarawak, Malaysia. It focuses on building defects pattern for school building. The primary data collection is from the school building condition survey with involvement of 24 primary schools. The schools have been selected using simple random sampling and stratified sampling (of school age as the variable of selection. The reporting method is based on Condition Survey Protocol (CSP 1 Matrix. Data analysis covers descriptive and inferential statistics. The analysis carried out found that the overall 4,725 defects have been identified. The building defect pattern is mainly on Ground Level of 3,176 defects, the highest number of defects components found on walls (798. 16.2% defects are cracks from 11 common defects and most of all the highest score of defects based on age of the building were the building in the range of 11 to 20 years.

  2. Integrated Building Design

    DEFF Research Database (Denmark)

    Heiselberg, Per

    In the first half of the 20th century, HVAC systems and artificial lighting were developed to meet indoor comfort needs. Before the introduction of mechanical systems, climate - not building style or appearance - was the major determinant of building form. Comfort was achieved through passive means...

  3. Heat loss from Buildings

    DEFF Research Database (Denmark)

    Karlsson, Kenneth; Næraa, Rikke

    1997-01-01

    Determination of heat loss coefficients for buildings in Denmark. The coefficient are determined for 15 building groups and 3 year intervals. They are based on the BBR-registre and assumptions of U-values(W/K*m2)and computed in a simple spreed sheet model.The results are used in the REVEILLE...... project for calculations in the SESAM model....

  4. Body-building

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正In recent years, more and more people spare no pains to join in the body-building group. People begin to take part in various fitness clubs or fitness centers in their spare time. This shows body-building has become an indispensable part of many people’s life.

  5. Building a Data Warehouse.

    Science.gov (United States)

    Levine, Elliott

    2002-01-01

    Describes how to build a data warehouse, using the Schools Interoperability Framework (www.sifinfo.org), that supports data-driven decision making and complies with the Freedom of Information Act. Provides several suggestions for building and maintaining a data warehouse. (PKP)

  6. LARGE BUILDING RADON MANUAL

    Science.gov (United States)

    The report summarizes information on how bilding systems -- especially the heating, ventilating, and air-conditioning (HVAC) system -- inclurence radon entry into large buildings and can be used to mitigate radon problems. It addresses the fundamentals of large building HVAC syst...

  7. Dancing building prevents collapse

    NARCIS (Netherlands)

    Visscher, R.

    2007-01-01

    In future, anybody caught inside a building during an earthquake need no longer fear the roof collapsing on them. Thanks to the use of composite materials, all the building will do is dance along, riding the waves of the earthquake. At least, according to Professor Ir. Adriaan Beukers of the Aerospa

  8. Energy Performance of Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per

    2007-01-01

    emissions in the coming years. By approving the Energy Performance in Buildings Directive the European Union has taken a strong leadership role in promoting energy efficiency in buildings in Europe, and the Directive will be the most powerful instrument developed to date for the building sector in Europe...... programme (ECCP) was established in June 2000 to help identify the most environmentally cost-effective measures enabling the EU to meet its target under the Kyoto Protocol, namely an 8% reduction in greenhouse gas emissions from 1990 levels by 2012. Energy use in buildings accounts for almost half of all CO......-effective energy saving potential of between 22% and 40% of the energy consumption in the sector by the year 2020. The paper presents the European approach to improve sustainability in the building sector, which has a very high potential for considerable reduction of energy consumption and green house gas...

  9. CERN's newest building

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    With a growing number of users looking for offices, the shortage of space has become acute, particularly for physicists. Building 42, inaugurated on Friday 11 February, offers almost 300 new work-spaces and a particularly pleasant working environment.   Mauro Dell’Ambrogio, the Swiss State Secretary for Education and Research (left), Rolf Heuer , CERN Director-General (centre), and Mark Muller, President of the Government of the Republic and Canton of Geneva and Head of the Department of Construction and Information Technology (right) at the opening of Building 42 on 11 February, 2011.   Construction work for the new Building 42 began in January 2009, thanks to support from the Swiss foundation FIPOI (Fondation des immeubles pour les organisations internationales). After two years of work, the building, an extension of Building 40, is ready to accommodate physicists from around the world who have come to work on the LHC. "We had more than 25 external contractors working...

  10. Knowledge formalization of intelligent building

    Science.gov (United States)

    Žáček, Martin

    2016-06-01

    This article aim is understanding the basic knowledge about an intelligent building. The notion of the intelligent building can be called any building equipped with computer and communication technology, which can automatically respond to internal or external stimuli. The result of the intelligent building is an automated and foreseeing of activities that enable to reduce operating costs and increase comfort. The best way to use the intelligent building is for a low-energy building, a passive building, or for building with high savings. The output of this article is the formalization of basic knowledge of the intelligent building by RDF graph.

  11. Energy management systems in buildings

    Energy Technology Data Exchange (ETDEWEB)

    Lush, D.M.

    1979-07-01

    An investigation is made of the range of possibilities available from three types of systems (automatic control devices, building envelope, and the occupants) in buildings. The following subjects are discussed: general (buildings, design and personnel); new buildings (envelope, designers, energy and load calculations, plant design, general design parameters); existing buildings (conservation measures, general energy management, air conditioned buildings, industrial buildings); man and motivation (general, energy management and documentation, maintenance, motivation); automatic energy management systems (thermostatic controls, optimized plant start up, air conditioned and industrial buildings, building automatic systems). (MCW)

  12. Building Software with Gradle

    CERN Document Server

    CERN. Geneva; Studer, Etienne

    2014-01-01

    In this presentation, we will give an overview of the key concepts and main features of Gradle, the innovative build system that has become the de-facto standard in the enterprise. We will cover task declaration and task graph execution, incremental builds, multi-project builds, dependency management, applying plugins, extracting reusable build logic, bootstrapping a build, and using the Gradle daemon. By the end of this talk, you will have a good understanding of what makes Gradle so powerful yet easy to use. You will also understand why companies like Pivotal, LinkedIn, Google, and other giants with complex builds count on Gradle. About the speakers Etienne is leading the Tooling Team at Gradleware. He has been working as a developer, architect, project manager, and CTO over the past 15 years. He has spent most of his time building software products from the ground up and successfully shipping them to happy customers. He had ...

  13. Building Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Heli Koukkari

    2010-07-01

    Full Text Available Although social, economic, and cultural indicators are of substantial importance to the concept of sustainable building, this concept is usually related to environmental characteristics. Any building level assessment method is complex and involves contradictory aspects. Moreover, emphasizing qualitative criteria only increases confusion. R&D and standardization are thus concentrated to transparency and usability of the environmental methods. Other directions of research aim at performance-based design and methods to take regional and cultural aspects into account. In this paper, the perspectives of the sustainability assessment of a whole building are presented, based on a state of the art, feasibility study on performance analysis and the development of an extended life-cycle assessment for buildings. Using various tools, and based on the case studies of building sustainability assessment, environmental indicators were often shown to be of lesser importance than the other, soft ones. The first steps in the development of a building sustainability assessment method for Portuguese residential buildings will be presented and discussed in the end.

  14. Buildings Interoperability Landscape

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wang, Weimin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Corbin, Charles D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Widergren, Steven E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-12-31

    Through its Building Technologies Office (BTO), the United States Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE-EERE) is sponsoring an effort to advance interoperability for the integration of intelligent buildings equipment and automation systems, understanding the importance of integration frameworks and product ecosystems to this cause. This is important to BTO’s mission to enhance energy efficiency and save energy for economic and environmental purposes. For connected buildings ecosystems of products and services from various manufacturers to flourish, the ICT aspects of the equipment need to integrate and operate simply and reliably. Within the concepts of interoperability lie the specification, development, and certification of equipment with standards-based interfaces that connect and work. Beyond this, a healthy community of stakeholders that contribute to and use interoperability work products must be developed. On May 1, 2014, the DOE convened a technical meeting to take stock of the current state of interoperability of connected equipment and systems in buildings. Several insights from that meeting helped facilitate a draft description of the landscape of interoperability for connected buildings, which focuses mainly on small and medium commercial buildings. This document revises the February 2015 landscape document to address reviewer comments, incorporate important insights from the Buildings Interoperability Vision technical meeting, and capture thoughts from that meeting about the topics to be addressed in a buildings interoperability vision. In particular, greater attention is paid to the state of information modeling in buildings and the great potential for near-term benefits in this area from progress and community alignment.

  15. INL Green Building Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer Dalton

    2005-05-01

    Green buildings, also known as sustainable buildings, resource efficient buildings, and high performance buildings, are structures that minimize the impact on the environment by using less energy and water, reducing solid waste and pollutants, and limiting the depletion of natural resources. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish the mission. This infrastructure, particularly the buildings, should incorporate green design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. With this in mind, the recommendations described in this strategy are intended to form the INL foundation for green building standards. The recommendations in this strategy are broken down into three levels: Baseline Minimum, Leadership in Energy and Environmental Design (LEED)Certification, and Innovative. Baseline Minimum features should be included in all new occupied buildings no matter what the purpose or size. These features do not require significant research, design, or capital costs and yet they can reduce Operation and Maintenance (O&M) costs and produce more environmentally friendly buildings. LEED Certification features are more aggressive than the Baseline Minimums in that they require documentation, studies, and/or additional funding. Combined with the Baseline Minimums, many of the features in this level will need to be implemented to achieve the goal of LEED certification. LEED Silver certification should be the minimum goal for all new buildings (including office buildings, laboratories, cafeterias, and visitor centers) greater than 25,000 square feet or a total cost of $10 million. Innovative features can also contribute to LEED certification, but are less mainstream than those listed in the previous two levels. These features are identified as areas where

  16. Environmental indicators for buildings

    DEFF Research Database (Denmark)

    Dammann, Sven

    Environmental Indicators for Buildings are studied using two different perspectives: with a technological, environmental scientific departing point and with a social scientific departing point. Different relevant groups in the building sector are identified and analysed, using the Social...... Construction Of Technology theory as a frame for the studies. It is concluded that it is not possible to develop a common set of indicators that all the central actors in the building sector find acceptable - at least not in a near future. Different sets of solutions are, however, outlined in the thesis...

  17. Mycotoxins in building materials

    DEFF Research Database (Denmark)

    Nielsen, Kristian Fog; Frisvad, Jens Christian

    2011-01-01

    as in future energy efficient buildings. It brings together different disciplinary points of view on indoor mold, ranging from physics and material science to microbiology and health sciences. The contents have been outlined according to three main issues: Fundamentals, particularly addressing the crucial...... for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures. This book aims to describe the fundamentals of indoor mold growth as a prerequisite to tackle mold growth in the existing building stock as well...

  18. The corporate brand building

    OpenAIRE

    Wisterová, Veronika

    2011-01-01

    The target of this master's thesis is to follow the process of corporate brand building of the company Starkl zahradník, to analyse it and to suggest possible improvements. The thesis is divided into four main sections. The first section deals with the theoretical aspects of the corporate brand building. The second section observes the process of brand building of the brand Starkl zahradník. The third section deals with the survey that was carried out and analyse its results. This survey was ...

  19. Building Social Web Applications

    CERN Document Server

    Bell, Gavin

    2009-01-01

    Building a web application that attracts and retains regular visitors is tricky enough, but creating a social application that encourages visitors to interact with one another requires careful planning. This book provides practical solutions to the tough questions you'll face when building an effective community site -- one that makes visitors feel like they've found a new home on the Web. If your company is ready to take part in the social web, this book will help you get started. Whether you're creating a new site from scratch or reworking an existing site, Building Social Web Applications

  20. Textural features in pre-treatment [F18]-FDG-PET/CT are correlated with risk of local recurrence and disease-specific survival in early stage NSCLC patients receiving primary stereotactic radiation therapy

    International Nuclear Information System (INIS)

    Textural features in FDG-PET have been shown to provide prognostic information in a variety of tumor entities. Here we evaluate their predictive value for recurrence and prognosis in NSCLC patients receiving primary stereotactic radiation therapy (SBRT). 45 patients with early stage NSCLC (T1 or T2 tumor, no lymph node or distant metastases) were included in this retrospective study and followed over a median of 21.4 months (range 3.1–71.1). All patients were considered non-operable due to concomitant disease and referred to SBRT as the primary treatment modality. Pre-treatment FDG-PET/CT scans were obtained from all patients. SUV and volume-based analysis as well as extraction of textural features based on neighborhood gray-tone difference matrices (NGTDM) and gray-level co-occurence matrices (GLCM) were performed using InterView Fusion™ (Mediso Inc., Budapest). The ability to predict local recurrence (LR), lymph node (LN) and distant metastases (DM) was measured using the receiver operating characteristic (ROC). Univariate and multivariate analysis of overall and disease-specific survival were executed. 7 out of 45 patients (16%) experienced LR, 11 (24%) LN and 11 (24%) DM. ROC revealed a significant correlation of several textural parameters with LR with an AUC value for entropy of 0.872. While there was also a significant correlation of LR with tumor size in the overall cohort, only texture was predictive when examining T1 (tumor diameter < = 3 cm) and T2 (>3 cm) subgroups. No correlation of the examined PET parameters with LN or DM was shown. In univariate survival analysis, both heterogeneity and tumor size were predictive for disease-specific survival, but only texture determined by entropy was determined as an independent factor in multivariate analysis (hazard ratio 7.48, p = .016). Overall survival was not significantly correlated to any examined parameter, most likely due to the high comorbidity in our cohort. Our study adds to the growing evidence

  1. Building Technologies Program Key Activities

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-15

    The Building Technologies Program (BTP) employs a balanced approach to making buildings more energy efficient. The three pillars of our program, research and development (R&D), market stimulation, and building and equipment standards, help meet our strategic vision.

  2. Green buildings pay

    DEFF Research Database (Denmark)

    Naboni, Emanuele; Edwards, Brian

    2012-01-01

    The new edition of ‘Green Buildings Pay’ authored by Brian Edwards and Emanuele Naboni explores the business and professional benefits which derive from architectural design driven by sustainability. With a new sub-title ‘Green Buildings Pay: design, productivity and ecology’ the book argues...... or environmental thinking and this finds expression in new approaches to the design of building facades, roofs, atria. Another is that new software simulation tools have changed energy assumptions and hence building forms. In a fast evolving arena, the book shows how architects are reshaping their practices....... Branding via LEED and BREEAM has taken green ideas to China and other emerging economies. The globalization of sustainability and of architectural practice is an important strand of the new edition....

  3. Helping clients build credit

    OpenAIRE

    Vikki Frank

    2007-01-01

    Until now people who repaid loans from community groups had not been on credit bureaus’ radar. Now Credit Builders Alliance is partnering with Experian to help clients of community lenders build strong credit histories.

  4. Municipal Building Energy Usage

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This data set contains energy use data from 2009-2014 for 139 municipally operated buildings. Metrics include: Site & Source EUI, annual electricity, natural...

  5. Buildings Sector Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.

    2005-08-01

    A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.

  6. Building Services Systems

    DEFF Research Database (Denmark)

    Zinzi, Michele; Romeo, Carlo; Thomsen, Kirsten Engelund;

    2015-01-01

    of the description of 5 main technologies: condensing boilers, heat pumps, ventilation systems, lighting and photovoltaic systems. For each technology chapter there is the same content list: an introduction, a brief technology description, some advantages and disadvantages, market penetration and utilisation, energy......This guideline on Building Services Systems is one of four guidelines produced by the School of the Future project. The other three guidelines cover: Building Construction Elements, Improved Indoor Environmental Quality and Concepts for Zero Emission Schools. This guideline consists...

  7. Building Peaceful Borders

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    China's efforts to build a harmonious world begin with establishing peaceful borders with its neighbors China's recent contribution to the world of international relations is the promotion of "building a harmonious world together," put forward by President Hu Jintao at the 60th anniversary of the UN in September 2005. As the core of the country's peaceful foreign policy in the new era, this approach has been well received and widely discussed in the international community. Meanwhile, Chinese foreign pol...

  8. Building Materials in Arctic Climate

    DEFF Research Database (Denmark)

    Jensen, Ole Mejlhede

    2005-01-01

    Building in the artic requires special attention on the appropriateness of building materials. The harsh climate makes execution difficult and sets unusual requirements for the pure material properties. In addition, there is a lack of choice of good, natural building materials in the arctic....... This results in high transport costs. The building materials situation in Greenland may potentially be improved by intensifying the reuse of building materials or by promoting the local production of building materials....

  9. Building Services Requests Subsystem (BSRS)

    Data.gov (United States)

    Department of Transportation — Lotus Notes workflow application used for the submission, processing, tracking and reporting of building service related requiests. Enables regional office building...

  10. Building Better Buildings: Sustainable Building Activities in California Higher Education Systems.

    Science.gov (United States)

    Sowell, Arnold; Eichel, Amanda; Alevantis, Leon; Lovegreen, Maureen

    2003-01-01

    This article outlines the activities and recommendations of California's sustainable building task force, discusses sustainable building activities in California's higher education systems, and highlights key issues that California is grappling with in its implementation of sustainable building practices. (EV)

  11. Development of two Danish building typologies for residential buildings

    DEFF Research Database (Denmark)

    Kragh, Jesper; Wittchen, Kim Bjarne

    2014-01-01

    performance of the residential building stock. Overall, the typologies consist of two types of building models—real example models and average designed models. The main purpose of developing the building typologies was to establish a tool able to calculate different energy-saving scenarios for the entire...... residential building stock. To make such calculations of scenarios, similar average designed building models were established based on extracted average values from the Danish Energy Performance Certification Scheme database. The two building typologies had the same overall composition, i.e., three main...... building types: single-family houses, terraced houses and blocks of flats. Each main building type is presented for nine periods representing age, typical building tradition and insulation levels. Finally, an energy balance model of the residential building stock was devised to validate the average...

  12. SOLAR EFFECTS ON BUILDING DESIGN.

    Science.gov (United States)

    Building Research Inst., Inc., Washington, DC.

    A REPORT OF A PROGRAM HELD AS PART OF THE BUILDING RESEARCH INSTITUTE 1962 SPRING CONFERENCE ON THE SOLAR EFFECTS ON BUILDING DESIGN. TOPICS DISCUSSED ARE--(1) SOLAR ENERGY DATA APPLICABLE TO BUILDING DESIGN, (2) THERMAL EFFECTS OF SOLAR RADIATION ON MAN, (3) SOLAR EFFECTS ON ARCHITECTURE, (4) SOLAR EFFECTS ON BUILDING COSTS, (5) SELECTION OF…

  13. Buildings for advanced technology

    CERN Document Server

    Teague, E; Murday, James

    2015-01-01

    This book deals with the design and construction of buildings for nanoscale science and engineering research. The information provided in this book is useful for designing and constructing buildings for such advanced technologies as nanotechnology, nanoelectronics and biotechnology. The book outlines the technology challenges unique to each of the building environmental challenges outlined below and provides best practices and examples of engineering approaches to address them: • Establishing and maintaining critical environments: temperature, humidity, and pressure • Structural vibration isolation • Airborne vibration isolation (acoustic noise) • Isolation of mechanical equipment-generated vibration/acoustic noise • Cost-effective power conditioning • Grounding facilities for low electrical interference • Electromagnetic interference (EMI)/Radio frequency interference (RFI) isolation • Airborne particulate contamination • Airborne organic and chemical contamination • Environment, safety a...

  14. On building Information Warehouses

    CERN Document Server

    Laha, Arijit

    2009-01-01

    One of the most important goals of information management (IM) is supporting the knowledge workers in performing their works. In this paper we examine issues of relevance, linkage and provenance of information, as accessed and used by the knowledge workers. These are usually not adequately addressed in most of the IT based solutions for IM. Here we propose a non-conventional approach for building information systems for supporting the knowledge workers which addresses these issues. The approach leads to the ideas of building Information Warehouses (IW) and Knowledge work Support Systems (KwSS). Such systems can open up potential for building innovative applications of significant impact, including those capable of helping organizations in implementing processes for double-loop learning.

  15. Automated model building

    CERN Document Server

    Caferra, Ricardo; Peltier, Nicholas

    2004-01-01

    This is the first book on automated model building, a discipline of automated deduction that is of growing importance Although models and their construction are important per se, automated model building has appeared as a natural enrichment of automated deduction, especially in the attempt to capture the human way of reasoning The book provides an historical overview of the field of automated deduction, and presents the foundations of different existing approaches to model construction, in particular those developed by the authors Finite and infinite model building techniques are presented The main emphasis is on calculi-based methods, and relevant practical results are provided The book is of interest to researchers and graduate students in computer science, computational logic and artificial intelligence It can also be used as a textbook in advanced undergraduate courses

  16. Building information deduced

    DEFF Research Database (Denmark)

    Tamke, Martin; Myrup Jensen, Morten; Beetz, Jakob;

    2014-01-01

    In recent years, Building Information Models have become commonplace in building profession. The extensive use and increasing experience with BIM models offers new perspectives and potentials for design and planning. A recent stakeholder study conducted by the authors of this paper show...... of a model, differences in separate models or models from different point of time. Current BIM tools support both modes only in a rudimentary form. This paper discusses current modes of information query within and across BIM models, shows beneficial scenarios for building and planning practice through...... that in practice models are no longer solely observed as culmination of knowledge in a 3d representation of future built structures, but as a source of information in itself. Experienced users of BIM want to Find Information within a model or across a set of these and Compare models in order to evaluate states...

  17. Zero Energy Building

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Heiselberg, Per; Bourrelle, J.S.;

    2011-01-01

    , (4) the type of energy balance, (5) the accepted renewable energy supply options, (6) the connection to the energy infrastructure and (7) the requirements for the energy efficiency, the indoor climate and in case of gird connected ZEB for the building–grid interaction. This paper focuses......The concept of Zero Energy Building (ZEB) has gained wide international attention during last few years and is now seen as the future target for the design of buildings. However, before being fully implemented in the national building codes and international standards, the ZEB concept requires...... clear and consistent definition and a commonly agreed energy calculation methodology. The most important issues that should be given special attention before developing a new ZEB definition are: (1) the metric of the balance, (2) the balancing period, (3) the type of energy use included in the balance...

  18. Carbon Efficient Building Solutions

    Directory of Open Access Journals (Sweden)

    Pellervo Matilainen

    2010-03-01

    Full Text Available Traditionally, the Finnish legislation have focused on energy use and especially on energy used for heating space in buildings. However, in many cases this does not lead to the optimal concept in respect to minimizing green house gases. This paper studies how CO2 emission levels are affected by different measures to reduce energy use in buildings. This paper presents two real apartment buildings with different options of energy efficiency and power sources. The calculations clearly show that in the future electricity and domestic hot water use will have high importance in respect to energy efficiency, and therefore also CO2 equivalent (eq emissions. The importance increases when the energy efficiency of the building increases. There are big differences between average Finnish production and individual power plants; CO2 eq emissions might nearly double depending on the energy source and the power plant type. Both a building with an efficient district heating as a power source, and a building with ground heat in addition to nuclear power electricity as a complimentary electricity source performed very similarly to each other in respect to CO2 eq emissions. However, it is dangerous to conclude that it is not important which energy source is chosen. If hypothetically, the use of district heating would dramatically drop, the primary energy factor and CO2 eq emissions from electricity would rise, which in turn would lead to the increase of the ground heat systems emissions. A problem in the yearly calculations is that the fact that it is very important, sometimes even crucial, when energy is needed, is always excluded.

  19. Climate Responsive Buildings in China

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; Heiselberg, Per

    2006-01-01

    There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...... of responsive building elements, of integrated building concepts and of environmental performance assessment methods to improve and optimize responsive building elements to develop and optimize new building concepts with integration of responsive building elements, HVAC-systems as well as natural and renewable...... energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work within the framework of the Annex44 of the International Energy Agency (IEA...

  20. Architecture Building Sustainability

    Institute of Scientific and Technical Information of China (English)

    DAVID HENDRICKSON

    2006-01-01

    @@ Leading architectural design and engineering firm, Skidmore,Owings, & Merrill (SOM), is renowned for pushing the envelope, masterminding some of the world's most cutting edge and enduring structural masterpieces - America's tallest building, the Sears Tower,in the firm's home city of Chicago, the 88-story Jinmao Tower in Shanghai, and the Freedom Tower in New York City, successor to the fallen World Trade Center complex,are among the well known projects in its building portfolio. SOM's next high profile assignment, the Pearl River Tower, in Guangzhou is one no less worthy of this tradition.

  1. PV cool-build

    Energy Technology Data Exchange (ETDEWEB)

    Cross, B.; Nuh, D.

    2004-07-01

    This report summarises the findings of a project to develop a method for calculating the operating temperature of building integrated photovoltaic (BIPV) modules/laminates which are estimated to operate above ambient temperature. The aim of the study was to minimise the temperature of the BIPV in order to increase the production of clean electricity. Details are given of a series of indoor experiments, computer modelling, and outdoor measurements. The production of a readily available, user-friendly design guide for architects and building designers is discussed.

  2. Building global learning communities

    Directory of Open Access Journals (Sweden)

    Averill Gordon

    2013-09-01

    Full Text Available Within the background where education is increasingly driven by the economies of scale and research funding, we propose an alternative online open and connected framework (OOC for building global learning communities using mobile social media. We critique a three year action research case study involving building collaborative global learning communities around a community of practice of learning researchers and practitioners. The results include the development of a framework for utilising mobile social media to support collaborative curriculum development across international boundaries. We conclude that this framework is potentially transferrable to a range of educational contexts where the focus is upon student-generated mobile social media projects.

  3. Ecology Beyond Building

    DEFF Research Database (Denmark)

    Peters, Terri

    2011-01-01

    As the designers of the WWf building in Zeist, The Netherslands a CO2-neutral, self-sufficient office complex, RAU has set the bar for sustainable research and design. Guesteditor Terri Peters visited the firm's studio in Amsterdam to talk to principal Thomas Rau. As Peters relates, Rau prefers t...... to put on the dwindling supply of raw materials rather than the immidiate problems of energy consumption for which there are solutions within reach. With the emphasis on a more far-reaching approach, he places buildings in a wider context of ecological thinking and systems....

  4. Building the perfect PC

    CERN Document Server

    Thompson, Robert Bruce

    2006-01-01

    This popular Build-It-Yourself (BIY) PC book covers everything you want to know about building your own system: Planning and picking out the right components, step-by-step instructions for assembling your perfect PC, and an insightful discussion of why you'd want to do it in the first place. Most big brand computers from HP, Dell and others use lower-quality components so they can meet their aggressive pricing targets. But component manufacturers also make high-quality parts that you can either purchase directly, or obtain through distributors and resellers. Consumers and corporations

  5. Disease specific stress of tumor patients at the beginning of radiotherapy. Effect on psychosocial support requirement; Krankheitsspezifische Belastungen von Tumorpatienten zu Beginn einer Strahlentherapie. Auswirkungen auf den psychosozialen Betreuungsbedarf

    Energy Technology Data Exchange (ETDEWEB)

    Sehlen, S.; Hollenhorst, H.; Schymura, B.; Firsching, M.; Duehmke, E. [Ludwig-Maximilians-Univ., Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Aydemir, U. [Inst. fuer Biometrie und Epidemiologie, Klinikum Grosshadern, Ludwig-Maximilians-Univ., Muenchen (Germany); Herschbach, P. [Technische Univ. Muenchen (Germany). Inst. und Poliklinik fuer Psychosomatische Medizin, Psychotherapie und medizinische Psychologie

    2001-10-01

    Purpose: Radiotherapy brings a tumor patient into a special life situation in which different variables play a role of often unknown importance. The goal of this study was to investigate disease specific stress of tumor patients at the beginning of radiotherapy with established psychodiagnostic questionnaires and to evaluate the effect on psychosocial support requirement in order to reduce stress and to improve quality of life and compliance during radiotherapeutical treatment. Patients and Methods: 732 patients were screened, of whom 446 (60.9%) fulfilled the criteria for inclusion (refusals 21.0%, low Karnofsky performance status 6.6%, management problems 3.4%, language barriers 3.0%, cognitive restrictions 2.6%, death 2.5%). Disease specific aspects of stress in the questionnaire (Fragebogen zur Belastung von Krebspatienten, FBK), life situation (LS) and self-defined care requirements (BB) were self-rated by patients with different tumor types before radiotherapy. Medical and sociodemographic data were also documented. We investigated 446 patients (262 male, 184 female; median age 60.0 years) with different diagnoses. Results: Stress was observed mainly due to reduction of efficiency, anxiety and pain on the subscales. Women had a significant higher stress on subscales of pain (p=0.016) and anxiety (p=0.009), patients younger than 45 years in the subscale information (p=0.002) and patients older than 45 and younger than 60 years in the subscale anxiety (p=0.002) and the total score (p=0.003). Patients with mamma carcinoma had the highest stress. The maximum percentages of patients under high stress were found for the subscales of efficiency (43%) and anxiety (40%). The support requirement was characterized by the need of more medical information and dialogue with the doctor. We saw a significant correlation of high stress and high care requirement. Conclusions: Psychosocial support should be founded on psychosocial stress diagnostic and self-defined care

  6. The development of the 'Quality-of-life for Respiratory Illness Questionnaire (QOL-RIQ)': a disease-specific quality-of-life questionnaire for patients with mild to moderate chronic non-specific lung disease.

    Science.gov (United States)

    Maillé, A R; Koning, C J; Zwinderman, A H; Willems, L N; Dijkman, J H; Kaptein, A A

    1997-05-01

    Chronic non-specific lung disease (CNSLD) encompasses asthma as well as chronic obstructive pulmonary disease (COPD). Recently in health care, there has been increasing awareness in the functional, psychological and social aspects of the health of patients; their quality of life (QOL). Quality-of-life research addressing CNSLD patients has been rather underdeveloped for a long period of time. Recently, however, the importance of QOL is being increasingly recognized, and several research groups have started to study QOL in CNSLD patients in more detail. This paper describes the construction of a disease-specific QOL instrument for patients with mild to moderately severe CNSLD. Items relating to several domains of QOL were listed, and 171 CNSLD patients in general practice were asked how much of a problem each item had been (assessed on a seven-point Likert scale). After applying an item-selection procedure, a uni-dimensional QOL questionnaire was constructed consisting of 55 items divided into seven domain subscales: breathing problems, physical problems, emotions, situations triggering or enhancing breathing problems, general activities, daily and domestic activities, and social activities, relationships and sexuality. Reliability estimates of the domain subscales of the constructed questionnaire varied from 0.68 to 0.89, and was 0.92 for the QOL for Respiratory Illness Questionnaire (QOL-RIQ) total scale. A first impression of the construct validity of the questionnaire was gained by investigation of the relationship between the QOL domain subscales and several indicators of illness severity, as well as the relative contribution of illness severity variables, background characteristics and symptoms to QOL, using regression analysis. Further research to validate the questionnaire to a greater extent (construct validity, test-retest reliability and responsiveness to change) is currently taking place. PMID:9176649

  7. Building the quantum network

    International Nuclear Information System (INIS)

    We show how quantum key distribution (QKD) techniques can be employed within realistic, highly secure communications systems, using the internet architecture for a specific example. We also discuss how certain drawbacks in existing QKD point-to-point links can be mitigated by building QKD networks, where such networks can be composed of trusted relays or untrusted photonic switches. (author)

  8. Moisture conditions in buildings

    DEFF Research Database (Denmark)

    Rode, Carsten

    2012-01-01

    Growth of mould requires the presence of moisture at a certain high level. In a heated indoor environment such moisture levels occur only if there is a reason for the moisture supply. Such moisture can come from the use of the building, because of malfunctioning constructions, or it can be the...

  9. Customer loyalty building

    OpenAIRE

    Nováková, Veronika

    2012-01-01

    This bachelor thesis focuses on the customer loyalty. It gives an example of CRM project which aims to build the loyalty of customers to some brand or product so the customer would return to the company and would be satisfied with all products and services he get.

  10. Building Project Competence

    DEFF Research Database (Denmark)

    Pemsel, Sofia; Wiewiora, Anna

    This research investigates the development of project competence, and particularly, three related dynamic capabilities (shifting, adapting, leveraging) that contribute to project competence development. In doing so, we make use of the emerging literature on knowledge governance and theorize how...... of dynamic capability building promoting project competence development....

  11. Building for International Business

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    When completed next August, the LG Beijing Tower project is sureto be one of the most high-end buildings in Beijing. With a meticulous attention to detail, planners know the ins and outs of the city's business momentum.The LG Beijing Tower will utilize an integrated networking system to ensure safety,efficiency and comfort.

  12. Ecology Beyond Building

    DEFF Research Database (Denmark)

    Peters, Terri

    2011-01-01

    As the designers of the WWf building in Zeist, The Netherslands a CO2-neutral, self-sufficient office complex, RAU has set the bar for sustainable research and design. Guesteditor Terri Peters visited the firm's studio in Amsterdam to talk to principal Thomas Rau. As Peters relates, Rau prefers...

  13. Radioactivity in building materials

    International Nuclear Information System (INIS)

    The present report, drawn up at the request of the former Minister of Public Health and Environmental Affairs of the Netherlands, discusses the potential radiological consequences for the population of the Netherlands of using waste materials as building materials in housing construction. (Auth.)

  14. Building a Twig Phylogeny

    Science.gov (United States)

    Flinn, Kathryn M.

    2015-01-01

    In this classroom activity, students build a phylogeny for woody plant species based on the morphology of their twigs. Using any available twigs, students can practice the process of cladistics to test evolutionary hypotheses for real organisms. They identify homologous characters, determine polarity through outgroup comparison, and construct a…

  15. Building Automation Systems.

    Science.gov (United States)

    Honeywell, Inc., Minneapolis, Minn.

    A number of different automation systems for use in monitoring and controlling building equipment are described in this brochure. The system functions include--(1) collection of information, (2) processing and display of data at a central panel, and (3) taking corrective action by sounding alarms, making adjustments, or automatically starting and…

  16. Life between buildings

    DEFF Research Database (Denmark)

    Gehl, Jan

    2001-01-01

    A classic is republished. Life between Buildings was first published in 1971. This book - frequently revised over the years - is still the best source for understanding how people use public spaces in our cities. Published in many languages, it is a standard textbook in Architecture and Planning...

  17. Gaze Interactive Building Instructions

    DEFF Research Database (Denmark)

    Hansen, John Paulin; Ahmed, Zaheer; Mardanbeigi, Diako

    We combine eye tracking technology and mobile tablets to support hands-free interaction with digital building instructions. As a proof-of-concept we have developed a small interactive 3D environment where one can interact with digital blocks by gaze, keystroke and head gestures. Blocks may be moved...

  18. Checklist for Physics Buildings.

    Science.gov (United States)

    American Inst. of Physics, New York, NY.

    This booklet was written to encourage close communication between architect and client and to assist planners of physics facilities in providing important features of building design. Some 300 items considered important are listed Also included is a list of 17 references related to facility construction (many available free of charge. A companion…

  19. Vedr.: Military capacity building

    DEFF Research Database (Denmark)

    Larsen, Josefine Kühnel; Struwe, Lars Bangert

    2013-01-01

    Kühnel Larsen and researcher Lars Bangert Struwe of CMS had organized a seminar in collaboration with Royal Danish Defense Colleg and the East African Security Governance Network. The seminar focused on some of the risks involved in Military capacity building and how these risks are dealt with from...

  20. Fire Protection for Buildings

    Science.gov (United States)

    Edmunds, Jane

    1972-01-01

    Reviews attack on fire safety in high rise buildings made by a group of experts representing the iron and steel industry at a recent conference. According to one expert, fire problems are people oriented, which calls for emphasis on fire prevention rather than reliance on fire suppression and for fire pretection to be built into a structure.…

  1. Building a Better CTO

    Science.gov (United States)

    Fletcher, Geoffrey H.

    2010-01-01

    This article features the new Framework of Essential Skills of the K-12 CTO of the Consortium for School Networking (CoSN). This latest, version 2.0 iteration of the skills framework builds upon work the organization did earlier this decade. This time CoSN, a professional association for district technology leaders, reached out to a variety of…

  2. Building Satellites is Easier

    Science.gov (United States)

    Marsh, Phyllis Nimmo

    1996-01-01

    'Building Satellites' is a story about Jim Marsh's recovery from a severe head injury told by his wife Phyllis from the moment she learned of its happening, through the ups and downs of a lengthy rehabilitation, until his return to work and daily living. It continues on, however, and narrates his battle with the more insidious Grave's disease. Told in the first person, 'Building Satellites' vividly portrays Phyllis's thoughts and feelings throughout this experience with scrupulous honestly. This is a story worth reading for many reasons. First of all, Jim was an accomplished scientist, respected by his colleagues both in this country and abroad. Secondly, it narrates the many stages of his recovery from head injury with detailed readable accuracy; it informs us as well as inspires. Finally, 'Building Satellites" also tells us the story of Phyllis Marsh's remarkable creative response to this crisis. It narrates her personal experiences as she progresses through the strange and somewhat bizarre world of medicine and rehabilitation, guided by a few basic beliefs, which she learned as a child in Iowa, that provided her with the strength to endure. 'Building Satellites' seems to reaffirm our unconscious, but settled conviction, that when confornted overnight with adversity, we are somehow given the means for coping, supported by our basic beliefs, strengthened by family and friends, and eventually learning to accept any outcome.

  3. Building Bridges to China.

    Science.gov (United States)

    Wasta, Stephanie; Scott, Margaret

    1998-01-01

    Describes a theme cycle called "Building Bridges to China" developed for third grade students that focuses on the similarities between the lives of children and families in China and the United States. Explains that the theme cycle addresses the National Geography Standards and three of the National Council for the Social Studies standards. (CMK)

  4. Building Background Knowledge

    Science.gov (United States)

    Neuman, Susan B.; Kaefer, Tanya; Pinkham, Ashley

    2014-01-01

    This article make a case for the importance of background knowledge in children's comprehension. It suggests that differences in background knowledge may account for differences in understanding text for low- and middle-income children. It then describes strategies for building background knowledge in the age of common core standards.

  5. Deactivation of Building 7602

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) has sponsored research and development programs in Building 7602 at Oak Ridge National Laboratory (ORNL) since 1984. This work focused on development of advanced technology for processing nuclear fuels. Building 7602 was used for engineering-scale tests using depleted and natural uranium to simulate the nuclear fuel. In April 1994 the DOE Office of Nuclear Energy (NE) sent supplemental FY 1994 guidance to ORNL stating that in FY 1995 and beyond, Building 7602 is considered surplus to NE programs and missions and shall be shut down (deactivated) and maintained in a radiologically and industrially safe condition with minimal surveillance and maintenance (S ampersand M). DOE-NE subsequently provided FY 1995 funding to support the deactivation activities. Deactivation of Building 7602 was initiated on October 1, 1994. The principal activity during the first quarter of FY 1995 was removal of process materials (chemicals and uranium) from the systems. The process systems were operated to achieve chemical solution concentrations needed for reuse or disposal of the solutions prior to removal of the materials from the systems. During this phase of deactivation the process materials processed and removed were: (1) Uranyl nitrate solution 30,178 L containing 4490 kg of uranium; (2) Nitric acid (neutralized) 9850 L containing less than 0.013 kg of uranium; (3) Organic solution 3346 L containing 265 kg of uranium; (4) Uranium oxide powder 95 kg; and (5) Miscellaneous chemicals. At the end of December 1994, the process systems and control systems were shut down and deactivated. Disposition of the process materials removed from the process systems in Building 7602 proved to be the most difficult part of the deactivation. An operational stand down and funding reductions at Y-12 prevented planned conversion of the uranyl nitrate solution to depleted uranium oxide powder. This led to disposal of the uranyl nitrate solution as waste

  6. PROGRESS IN ENERGY EFFICIENT BUILDINGS

    Energy Technology Data Exchange (ETDEWEB)

    Wall, L.W.; Rosenfeld, A.H.

    1982-12-01

    Recent accomplishments in buildings energy research by the diverse groups in the Energy Efficient Buildings Program at Lawrence Berkeley Laboratory (LBL) are summarized. We review technological progress in the areas of ventilation and indoor air quality, buildings energy performance, computer modeling, windows, and artificial lighting. The need for actual consumption data to track accurately the improving energy efficiency of buildings is being addressed by the Buildings Energy Data (BED) Group at LBL. We summarize results to date from our Building Energy Use Compilation and Analysis (BECA) studies, which include time trends in the energy consumption of new commercial and new residential buildings, the measured savings being attained by both commercial and residential retrofits, and the cost-effectiveness of buildings energy conservation measures. We also examine recent comparisons of predicted vs. actual energy usage/savings, and present the case for building energy use labels.

  7. Building a Model Astrolabe

    CERN Document Server

    Ford, Dominic

    2012-01-01

    This paper presents a hands-on introduction to the medieval astrolabe, based around a working model which can be constructed from photocopies of the supplied figures. As well as describing how to assemble the model, I also provide a brief explanation of how each of its various parts might be used. The printed version of this paper includes only the parts needed to build a single model prepared for use at latitudes around 52{\\deg}N, but an accompanying electronic file archive includes equivalent images which can be used to build models prepared for use at any other latitude. The vector graphics scripts used to generate the models are also available for download, allowing customised astrolabes to be made.

  8. Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Marszal, Anna Joanna; Bourrelle, Julien S.; Musall, Eike;

    2010-01-01

    The international cooperation project IEA SHC Task 40 / ECBCS Annex 52 “Towards Net Zero Energy Solar Buildings”, attempts to develop a common understanding and to set up the basis for an international definition framework of Net Zero Energy Buildings (Net ZEBs). The understanding of such buildings...... and how the Net ZEB status should be calculated differs in most countries. This paper presents an overview of Net ZEBs energy calculation methodologies proposed by organisations representing eight different countries: Austria, Canada, Denmark, Germany, Italy, Norway, Switzerland and the USA. The different...... parameters used in the calculations are discussed and the various renewable supply options considered in the methodologies are summarised graphically. Thus, the paper helps to understand different existing approaches to calculate energy balance in Net ZEBs, highlights the importance of variables selection...

  9. Building and using binoscopes

    CERN Document Server

    Butler, Norman

    2015-01-01

    Focusing on both homemade and commercial products, this book provides the reader with simple and straightforward information about the modelling and building of binoscopes. Binoscopes can be thought of as binoculars enlarged to the size of telescopes: essentially, a combination of the two. Constructing a binoscope is easier than most people think, but it still demands attention to detail and proper background knowledge. The author goes on to provide additional information about how to understand the products currently on the market, should the reader choose to purchase a binoscope instead of building one. Lastly, the book also compares binoscopes with telescopes in great detail, outlining the differences the reader can expect to see in the night sky from using both. The celestial views obtained with a binoscope, compared to a single telescope of the same aperture, are a very different experience and well worth the effort.

  10. Building synthetic memory

    OpenAIRE

    Inniss, Mara C.; Silver, Pamela A.

    2013-01-01

    Cellular memory – conversion of a transient signal into a sustained response – is a common feature of biological systems. Synthetic biologists aim to understand and reengineer such systems in a reliable and predictable manner. Synthetic memory circuits have been designed and built in vitro and in vivo based on diverse mechanisms such as oligonucleotide hybridization, recombination, transcription, phosphorylation, and RNA editing. Thus far, building these circuits has helped us explore the bas...

  11. BUILD UP Skills Danmark

    DEFF Research Database (Denmark)

    Forsingdal, Charlotte Vartou; Lauridsen, Vagn Holk; Hougaard, Karsten Frøhlich;

    opfyldelsen af 2020-målene, skal de rette kompetencer inden for energief-fektivitet og brug af vedvarende energi være til stede blandt de udførende i bygge- og an-lægsbranchen. Det er på denne baggrund, at Europa-Kommissionen har igangsat Build Up Skills projektet på tværs af Europa. Formålet med denne...

  12. Building a professional portfolio.

    OpenAIRE

    Arhippainen, Mikko

    2016-01-01

    Building a professional portfolio is a thesis report with buiding a professional portfolio for the author with a background in graphic design and event management with main interest on aesthetics side. This report describes the main process of selecting materials, planning and actually producing the portfolio. In addition to the portfolio there is a chapter with inspection on LinkedIn and other social medias when planning for jobsearch. Altogether it is many channels and a combination of ...

  13. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period, access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience. IT Department

  14. Work at Building 513

    CERN Multimedia

    IT Department

    2006-01-01

    As part of IT's preparations to meet the challenge of LHC computing, a new chilled water production unit is being constructed for the Computer Centre. The air conditioning work will start in mid-January and last until June 2006. During this period access to the car park of Building 513 will be restricted. Please consult the plan for details of the area affected by the work. With apologies for the inconvenience, IT Department

  15. NRC new sustainable building

    International Nuclear Information System (INIS)

    'Full text:' The National Research Council Institute For Fuel Cell Innovation is relocating to a purpose-built 71,343 sq. Ft. (6598 sq. M) Research, Testing, Evaluation, and Industry Incubation Facility in the spring of 2006. The new facility will contain Hydrogen-ready laboratories, the existing relocated Hydrogen Safe Environmental Test Chamber, a hydrogen vehicle maintenance bay, a hydrogen vehicle refuelling station, and the following demonstration projects and features: 1. A Ground Source Heat Pump: This long-proven natural-source heating and cooling technology to provide climate control for the new IFCI's atrium and galleria. It is being designed by Keen Engineering of North Vancouver, BC. 2. 5 KW Solid Oxide Fuel Cell System: Fuelled by natural gas and in the future, from biomass, the fuel cell will also produce approximately 15 kW of waste heat, which will be captured and used to supply heat for the building. The Solid Oxide Fuel Cell will be supplied by Fuel Cell Technologies in Kingston, ON. 3. LEED Building certification: Attaining LEED 'green building' certification is considered an important complement to the plans for the new NRC-IFCI, because it will provide respected third-party verification of government's commitment to efficient building design and construction. Project architects Bunting Coady of Vancouver, BC believe the IFCI has strong potential to earn gold LEED certification. 4. Photovoltaic hydrogen source for back-up power fuel cell system: A photovoltaic array will capture energy from sunlight to power an electrolyzer that will produce and store hydrogen for a PEM fuel cell emergency backup power system. The electrolyzer will be provided by Hydrogenics of Mississauga, ON. Photovoltaics are being designed and installed by the British Columbia Institute of Technology. (author)

  16. Thermal evaluation of buildings

    OpenAIRE

    Barajas, Luís M; Roset Calzada, Jaime; La Ferla, Giuseppe

    2015-01-01

    To COST ACTION TU 1104 "Smart Energy Regions" Prof. Aleksandra Djukic and Prof. Aleksandra Krstic-Furundzic of the Faculty of Architecture of the University of Belgrade, Serbia, that gave us the opportunity of be part of the training school imparted from Monday 20th to Thursday 23rd April 2015, where we can teach the topic. The convenience of the use of environmental building evaluation tools, to know design conditions and thermal behavior, by using bioclimatic strategies fo...

  17. Building retrofit for cities

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, H.

    1979-11-01

    The impact of high fuel prices on retrofit in the urban sector is discussed. Then, the benefits of a strong urban retrofit program are enumerated. Institutional, financial, informational, and attitudinal barriers that stand in the way of widespread implementation of energy conservation retrofit are discussed. Policy tools which can be used to implement a retrofit program consist of tax breaks, financing arrangements, mandatory building efficiency standards, and education programs.

  18. Building for energy conservation

    Energy Technology Data Exchange (ETDEWEB)

    Burberry, P.

    1978-01-01

    Ways in which buildings may be designed to increase thermal efficiency are discussed, giving first of all examples of thermal design in relation to climate. How the building itself may be designed to take advantage of solar energy and the ways in which heat loss takes place are described; the effect of design variables such as siting, volume, and insulation is shown. The book also reviews the development of thermal regulations for health and comfort and, more recently, energy conservation. It discusses the possitilities and difficulties of legislation for energy saving. The UK regulations are given in detail together with descriptions of the FHA and ASHRAE recommendations for the USA and the lastest Scandinavian norms. The author argues that no significant cost need be involved in many of the aspects of thermal design, e.g., shape and fenestration; and that these factors should automatically be taken into account by designers. Even existing buildings can be adapted in various respects to save energy consumption. The book concludes with an explanation of calculation methods for U-values, heat loss, plant sizing, seasonal heat requirements, and other procedures, amply illustrated with tables and graphs.

  19. Allegheny County Building Footprint Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains photogrammetrically compiled roof outlines of buildings. All near orthogonal corners are square. Buildings that are less than 400 square feet...

  20. ENERGY EFFICIENCY OF THE BUILDING

    OpenAIRE

    Bocharnikov, Dmitry

    2011-01-01

    The subject of bachelor’s thesis is about energy efficiency of the building. Much attention is being paid to energy saving problems all over the world. In the first part it theoretic base for thermal performance requirements of buildings. It includes main positions of Russian requirements for thermal performance. Also it is about general types of building envelope. The second part is about energy audit of buildings. In this part there is an energy efficiency assessment methodology. Energy eff...

  1. Upcoming renovations in Building 63

    CERN Multimedia

    2014-01-01

    La Poste will close its doors in Building 63 on Friday, 28 November. It moves to Building 510 and where it will open on 1 December (see picture).   UNIQA will close its HelpDesk in Building 63 on Wednesday, 26 November and will re-open the next day in Building 510. La Poste and UNIQA are expected to return to their renovated office space between April and May 2015.

  2. Hawaii-Okinawa Building Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, I.; Salasovich, J.

    2013-05-01

    NREL conducted energy evaluations at the Itoman City Hall building in Itoman, Okinawa Prefecture, Japan, and the Hawaii State Capitol building in Honolulu, Hawaii. This report summarizes the findings from the evaluations, including the best practices identified at each site and opportunities for improving energy efficiency and renewable energy. The findings from this evaluation are intended to inform energy efficient building design, energy efficiency technology, and management protocols for buildings in subtropical climates.

  3. Extensive Renovation of Heritage Buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn; Møller, Eva B.; Buch-Hansen, Thomas Cornelius

    2015-01-01

    In the debate on whether or not heritage buildings should be included in work to mitigate climate change impacts, it is important to assess the impact of these buildings. Therefore the results of an extensive energy upgrading of a listed complex was studied. Climate change and measures to mitigat...... a far more vulnerable building and change its robustness to withstand moisture and user behaviour....

  4. Classification of Building Object Types

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn

    2011-01-01

    be managed by software applications and on the basis of building models. Classification systems with taxonomies of building object types have many application opportunities but can still be beneficial in data exchange between building construction partners. However, this will be performed by new methods...... and in strong connection with databases holding a wide range of object types....

  5. Building a leadership brand.

    Science.gov (United States)

    Ulrich, Dave; Smallwood, Norm

    2007-01-01

    How do some firms produce a pipeline of consistently excellent managers? Instead of concentrating merely on strengthening the skills of individuals, these companies focus on building a broad organizational leadership capability. It's what Ulrich and Smallwood--cofounders of the RBL Group, a leadership development consultancy--call a leadership brand. Organizations with leadership brands take an "outside-in" approach to executive development. They begin with a clear statement of what they want to be known for by customers and then link it with a required set of management skills. The Lexus division of Toyota, for instance, translates its tagline--"The pursuit of perfection"--into an expectation that its leaders excel at managing quality processes. The slogan of Bon Secours Health System is "Good help to those in need." It demands that its managers balance business skills with compassion and caring. The outside-in approach helps firms build a reputation for high-quality leaders whom customers trust to deliver on the company's promises. In examining 150 companies with strong leadership capabilities, the authors found that the organizations follow five strategies. First, make sure managers master the basics of leadership--for example, setting strategy and grooming talent. Second, ensure that leaders internalize customers' high expectations. Third, incorporate customer feedback into evaluations of executives. Fourth, invest in programs that help managers hone the right skills, by tapping customers to participate in such programs. Finally, track the success of efforts to build leadership bench strength over the long-term. The result is outstanding management that persists even when individual executives leave. In fact, companies with the strongest leadership brands often become "leader feeders"--firms that regularly graduate leaders who go on to head other companies. PMID:17642128

  6. Sustainable Development and Green Buildings

    Directory of Open Access Journals (Sweden)

    Arijit Sinha

    2013-03-01

    Full Text Available Global sustainability goals have led to the development of the green building movement. The Green Building Program, stemming from the movement, has had unprecedented success as it provides a quantifiable metric to people’s efforts towards sustainable development. Sustainable development and green buildings are often used interchangeably. Although, sustainable development and green buildings are related, they are not the same. This paper provides an overview of how green building relates to sustainable development practices. Sustainability also governs decisions concerning building materials. A comprehensive explanation of what constitutes a green building material is discussed and how renewable material like wood fare in the deciding criteria. There are many green building rating systems in place. United States Green Building Council administered Leadership in Energy and Environment Design (LEED is the global market leader in the rating systems. LEED is a commendable and grand effort in moving towards sustainable development by converting the built environment green. However, it does have certain pitfalls and challenges. Some of these challenges are with respect to policies on material selection and performance monitoring. The materials used in a project are considered at a common starting point and no consideration is given to the life cycle performance of the material. Statements concerning sustainability require validation, and Life Cycle Analysis (LCA is a tool that can provide such validity. This paper presents how beneficial it can be, when included, in the bigger scheme of green building rating systems and introduces an integrated design concept for green buildings.

  7. Building Web Reputation Systems

    CERN Document Server

    Farmer, Randy

    2010-01-01

    What do Amazon's product reviews, eBay's feedback score system, Slashdot's Karma System, and Xbox Live's Achievements have in common? They're all examples of successful reputation systems that enable consumer websites to manage and present user contributions most effectively. This book shows you how to design and develop reputation systems for your own sites or web applications, written by experts who have designed web communities for Yahoo! and other prominent sites. Building Web Reputation Systems helps you ask the hard questions about these underlying mechanisms, and why they're critical

  8. Building Transdisciplinary Environmental Studies

    DEFF Research Database (Denmark)

    Holm, Jesper

    department (Dept. of Environment, Technology and Social Studies, Roskilde University), and has originally in another version been presented in the book “Miljøregulering - tværvidenskabelige studier (Environmental Regulation. Interdisciplinary Studies)” (Holm, Kjærgård & Pedersen eds. 1997, in Danish) written......We will in this paper approach the challenge of building integrated environmental studies by presenting a crude frame of analysis which take into account both the physical aspects and the social-discursive articulations of environmental problems. This framework partly mirrors the approach of our...

  9. Building Regional Competencies

    DEFF Research Database (Denmark)

    Norus, Jesper

    2004-01-01

    a dominating position in the global marketfor industrial enzymes from 1870-2004. The case of industrial enzymes shows how aregion has been able to build sustainable competitive advantages from its distinctivecompetencies. This is done through a mixture of outsourcing and in sourcing ofcompetencies, knowledge......This paper analyzes the foundations of regional knowledge and its long-term impact onthe region's companies' and how a particular knowledge has developed an ability tostay competitive within a specific technological field. The case illustrates how theCopenhagen region has been able to develop...

  10. ECOLOGICAL BUILDING DESIGN DETERMINANTS

    Directory of Open Access Journals (Sweden)

    Ali Vakili-Ardebili

    2010-11-01

    Full Text Available The sustainable building design process is driven on the basis of a range of design eco-indicators. Consideration of a multitude of eco-determinants, such as environment, economy, resources, energy consumption and society values in addition to design characteristics and contexts, makes the process of ecological design even more complex. A large number of eco-drivers are extracted from the literature and current design practices. To gain a better insight on eco-design determinants, a survey focusing on the use of eco-design drivers has been conducted with various architects in the UK. The factor analysis method was used to remove redundant data from the survey. Through the factor analysis approach, 115 eco-determinants are grouped into six main clusters. This article presents the process, analysis and findings of this work. The extracted eco-indicators and their associated clusters can be used to improve the process of ecological building design. DOI: 10.3763/aedm.2008.0096 Source: Architectural Engineering and Design Management, Volume 6, Number 2, 2010 , pp. 111-131(21

  11. Irregular Shaped Building Design Optimization with Building Information Modelling

    Directory of Open Access Journals (Sweden)

    Lee Xia Sheng

    2016-01-01

    Full Text Available This research is to recognise the function of Building Information Modelling (BIM in design optimization for irregular shaped buildings. The study focuses on a conceptual irregular shaped “twisted” building design similar to some existing sculpture-like architectures. Form and function are the two most important aspects of new buildings, which are becoming more sophisticated as parts of equally sophisticated “systems” that we are living in. Nowadays, it is common to have irregular shaped or sculpture-like buildings which are very different when compared to regular buildings. Construction industry stakeholders are facing stiff challenges in many aspects such as buildability, cost effectiveness, delivery time and facility management when dealing with irregular shaped building projects. Building Information Modelling (BIM is being utilized to enable architects, engineers and constructors to gain improved visualization for irregular shaped buildings; this has a purpose of identifying critical issues before initiating physical construction work. In this study, three variations of design options differing in rotating angle: 30 degrees, 60 degrees and 90 degrees are created to conduct quantifiable comparisons. Discussions are focused on three major aspects including structural planning, usable building space, and structural constructability. This research concludes that Building Information Modelling is instrumental in facilitating design optimization for irregular shaped building. In the process of comparing different design variations, instead of just giving “yes or no” type of response, stakeholders can now easily visualize, evaluate and decide to achieve the right balance based on their own criteria. Therefore, construction project stakeholders are empowered with superior evaluation and decision making capability.

  12. Parameters of Upgrading Existing Building into a Green Building

    OpenAIRE

    Mrs. Rupali Kapure; Dr.R.K.Jain

    2014-01-01

    Before turning to specific programs for upgrading buildings, it’s important to understand the market dynamics of greening existing buildings. From a macroeconomic perspective, energy efficiency upgrades represent the most cost-effective way to meet growing energy demands. From a microeconomic perspective, recent studies have shown that energy-efficient and certified green buildings merit higher market values, greater rents, and higher occupancies. From a corporate sustainabili...

  13. Towards more Manageable Coastal Building; Initial Coastal Building Construction Guidelines

    OpenAIRE

    Roslan Talib; Mohd Z. Sulieman

    2011-01-01

    Problem statement: As we may not be aware that the coastal construction is different from inland construction. Building in a coastal environment is different from building in an inland area. In general, buildings in coastal areas must be designed and built to withstand higher loads due to its more extreme conditions. Nowadays, the issue of global warming, uncertainty of global weather and the climate change effect indirectly creating the coastal area with much more expose to extreme condition...

  14. Parameters of Upgrading Existing Building into a Green Building

    Directory of Open Access Journals (Sweden)

    Mrs. Rupali Kapure

    2014-02-01

    Full Text Available Before turning to specific programs for upgrading buildings, it’s important to understand the market dynamics of greening existing buildings. From a macroeconomic perspective, energy efficiency upgrades represent the most cost-effective way to meet growing energy demands. From a microeconomic perspective, recent studies have shown that energy-efficient and certified green buildings merit higher market values, greater rents, and higher occupancies. From a corporate sustainability viewpoint, greening existing buildings is a direct way to reduce a company’s carbon footprint. As a result, corporate real estate managers in the United States have begun to decide in favour of greening both owned and leased buildings, seeing many economic benefits from this switch. Green buildings offer many marketing benefits for building owners and tenants, including opportunities for creating new green “brands” and also “future-proofing” their real estate against both future energy price increases and also value erosion as the trend toward green buildings continues to grow. Marketing benefits will vary by geographic location, building and tenant type, and other factors, but they are present in all privately owned real estate.

  15. Building America Case Study: Solar Water Heating in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    R. Aldrich and J. Williamson

    2016-05-01

    Solar domestic hot water (SDHW) systems have been installed on buildings for decades, but because of relatively high costs they have not achieved significant market penetration in most of the country. As more buildings move towards zero net energy consumption, however, many designers and developers are looking more closely at SDHW. In multifamily buildings especially, SDHW may be more practical for several reasons: (1) When designing for zero net energy consumption, solar water heating may be part of the lowest cost approach to meet water heating loads. (2.) Because of better scale, SDHW systems in multifamily buildings cost significantly less per dwelling than in single-family homes. (3) Many low-load buildings are moving away from fossil fuels entirely. SDHW savings are substantially greater when displacing electric resistance water heating. (4) In addition to federal tax incentives, some states have substantial financial incentives that dramatically reduce the costs (or increase the benefits) of SDHW systems in multifamily buildings. With support form the U.S. DOE Building America program, the Consortium for Advanced Residential Buildings (CARB) worked with a developer in western Massachusetts to evaluate a SDHW system on a 12-unit apartment building. Olive Street Development completed construction in spring of 2014, and CARB has been monitoring performance of the water heating systems since May 2014.

  16. Energy Efficiency, Building Productivity and the Commercial Buildings Market

    Energy Technology Data Exchange (ETDEWEB)

    Jones, D.W.

    2002-05-16

    The energy-efficiency gap literature suggests that building buyers are often short-sighted in their failure to apply life-cycle costing principles to energy efficient building technologies, with the result that under investment in these advanced technology occurs. This study examines the reasons this behavior may occur, by analyzing the pressures that market forces place on purchasers of buildings. Our basic conclusion is that the fundamental manner in which the buildings sector does business creates pressures to reduce initial capital outlays and to hedge against a variety of risks, including the ability of building owners to capture benefits from energy efficiency. Starting from the position that building buyers' willingness to pay drives choices over building attributes, we examine basic market principles, the structure of the buildings market, including the role of lenders, and policies that promote penetration of energy efficient technologies. We conclude that greater attention to buyers, and to the incentives and constraints they face, would promote a better understanding of building investment choices and contribute to better policies to promote the penetration of these technologies into markets.

  17. Guidelines for Building Science Education

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, Cheryn E.; Rashkin, Samuel; Huelman, Pat

    2015-03-11

    The U.S. Department of Energy’s (DOE) residential research and demonstration program, Building America, has triumphed through 20 years of innovation. Partnering with researchers, builders, remodelers, and manufacturers to develop innovative processes like advanced framing and ventilation standards, Building America has proven an energy efficient design can be more cost effective, healthy, and durable than a standard house. As Building America partners continue to achieve their stretch goals, they have found that the barrier to true market transformation for high performance homes is the limited knowledge-base of the professionals working in the building industry. With dozens of professionals taking part in the design and execution of building and selling homes, each person should have basic building science knowledge relevant to their role, and an understanding of how various home components interface with each other. Instead, our industry typically experiences a fragmented approach to home building and design. After obtaining important input from stakeholders at the Building Science Education Kick-Off Meeting, DOE created a building science education strategy addressing education issues preventing the widespread adoption of high performance homes. This strategy targets the next generation and provides valuable guidance for the current workforce. The initiative includes: • Race to Zero Student Design Competition: Engages universities and provides students who will be the next generation of architects, engineers, construction managers and entrepreneurs with the necessary skills and experience they need to begin careers in clean energy and generate creative solutions to real world problems. • Building Science to Sales Translator: Simplifies building science into compelling sales language and tools to sell high performance homes to their customers. • Building Science Education Guidance: Brings together industry and academia to solve problems related to

  18. Spintronics: Conceptual Building Blocks

    Science.gov (United States)

    Ansermet, J.-Ph.

    The purpose of this introduction to spintronics is to provide some elementary description of its conceptual building blocks. Thus, it is intended for a newcomer to the field. After recalling rudimentary descriptions of spin precession and spin relaxation, spin-dependent transport is treated within the Boltzmann formalism. This suffices to introduce key notions such as the spin asymmetry of the conductivities in the two-current model, the spin diffusion length, and spin accumulation. Two basic mechanisms of spin relaxation are then presented, one arising from spin-orbit scattering and the other from electron-magnon collisions. Finally, the action of a spin-polarized current on magnetization is presented in a thermodynamics framework. This introduces the notion of spin torque and the characteristic length scale over which the transverse spin polarization of conduction electron decays as it is injected into a magnet.

  19. Renovating the Main Building

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    CERN's "Main Building" is exactly that. The Organization's central hub, with hundreds of staff and visitors passing through its doors every day, will soon be getting a well-earned facelift. Refurbishment work will proceed in phases, starting with the Salle des Pas Perdus, the concourse between the Council Chamber and the Main Auditorium. By the end of August, informal seating areas will be installed, electronic display panels will provide practical information and improved sound insulation will enhance conditions in the auditoria and surrounding meeting rooms.   In light green the area that will undergo the facelift. Work will start in July. The ground floor is home to the entrance to Restaurant No. 1, the bank, the post office, the travel agent, the Users Office, the Staff Association, the notice boards etc. Step up to the first floor to access CERN's largest lecture theatre, the Council Chamber and its "Pas Perdus" lobby. Everyone who works at or visits CERN i...

  20. Building Land Information Policies

    DEFF Research Database (Denmark)

    Enemark, Stig

    2004-01-01

    The paper presents a conceptual understanding in the areas of Cadastre, Land Administration, and Land Management as a basis for building adequate land information policies. To develop this understanding the paper looks at each area as a system or an infrastructure designed for handling specific...... and judicial setting of the individual country. However, in spite of the different origins, the systems seem to merge into a global model serving some basic societal needs. The paper presents an outline of this development towards a global model for sustainable land administration infrastructures...... of measurement science, spatial information, management, and land management. (2) To establish national professional associations which accommodate a modern interdisciplinary profile. (3) To assess the capacity needs in land administration and to develop the capacity needed at societal, institutional...

  1. Photovoltaic building blocks

    DEFF Research Database (Denmark)

    Hanberg, Peter Jesper; Jørgensen, Anders Michael

    2014-01-01

    it directcompetitive with fossil energy sources a further reduction is needed. By increasing the efficiency of the solar cells one gain an advantage through the whole chain of cost. So that per produced Watt of power less material is spent, installation costs are lower, less area is used etc. With an average...... efficiency of about 15% for commercial Silicon solar cells there is still much to gain. DTU Danchip provides research facilities, equipment and expertise for the building blocks that comprises fabricating the efficient solar cell. In order to get more of the sun light into the device we provide thin film......Photovoltaics (PV), better known as solar cells, are now a common day sight on many rooftops in Denmark.The installed capacity of PV systems worldwide is growing exponentially1 and is the third most importantrenewable energy source today. The cost of PV is decreasing fast with ~10%/year but to make...

  2. Capacity Building in Land Management

    DEFF Research Database (Denmark)

    Enemark, Stig; Ahene, Rexford

    2003-01-01

    There is a significant need for capacity building in the interdisciplinary area of land management especially in developing countries and countries in transition, to deal with the complex issues of building efficient land information systems and sustainable institutional infrastructures. Capacity...... building in land management is not only a question of establishing a sufficient technological level or sufficient economic resources. It is mainly a question of understanding the interdisciplinary and cross-sectoral nature of land administration systems, and understanding the need for human resource...... development in this area. Furthermore, capacity building should ensure that the focus is on building sound institutions and governance rather than just high-level IT-infrastructures.    This overall approach to capacity building in land management is used for implementing a new land policy reform in Malawi...

  3. Building Energy Monitoring and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Tianzhen; Feng, Wei; Lu, Alison; Xia, Jianjun; Yang, Le; Shen, Qi; Im, Piljae; Bhandari, Mahabir

    2013-06-01

    This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.

  4. User Driven Innovative Building Design

    DEFF Research Database (Denmark)

    Christiansson, Per; Sørensen, Kristian Birch; Steffensen, K. G.;

    2009-01-01

    to the broad introduction of advanced information and communication technology (ICT). VICMET is a general method for user involvement in every phase of the construction process and with a unique setup for each type of user. VICMET can use already created information in the building process and emphasis...... that the users are the key to next level of successful building projects. VICMET defines four spaces to support the activities in a innovative/creative design process; The Contextual Inquiry Space, the Conceptual Modeling and Game Space, the Functional Building Systems (FBS) Consolidation Space, and the Solution......During recent years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as on the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due...

  5. Energy Innovations for Healthy Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Bogucz, Edward

    2016-09-23

    Healthy buildings provide high indoor environmental quality for occupants while simultaneously reducing energy consumption. This project advanced the development and marketability of envisioned healthy, energy-efficient buildings through studies that evaluated the use of emerging technologies in commercial and residential buildings. For commercial buildings, the project evaluated energy consumption and user experiences with a prototype Personalized Environmental Controls Systems (PECS) that enable individuals to control of conditions in their immediate surroundings within a larger office suite. For residential buildings, the project evaluated a variety of domestic hot water (DHW) technologies. The project also included outreach and education concerning energy efficiency in buildings, including resources required for homebuilders to participate in DOE’s Builders Challenge.

  6. Building better boards.

    Science.gov (United States)

    Nadler, David A

    2004-05-01

    Companies facing new requirements for governance are scrambling to buttress financial-reporting systems, overhaul board structures--whatever it takes to comply. But there are limits to how much good governance can be imposed from the outside. Boards know what they ought to be: seats of challenge and inquiry that add value without meddling and make CEOs more effective but not all-powerful. A board can reach that goal only if it functions as a high-performance team, one that is competent, coordinated, collegial, and focused on an unambiguous goal. Such entities don't just evolve; they must be constructed to an exacting blueprint--what the author calls board building. In this article, Nadler offers an agenda and a set of tools that boards can use to define and achieve their objectives. It's important for a board to conduct regular self-assessments and to pay attention to the results of those analyses. As a first step, the directors and the CEO should agree on which of the following common board models best fits the company: passive, certifying, engaged, intervening, or operating. The directors and the CEO should then analyze which business tasks are most important and allot sufficient time and resources to them. Next, the board should take inventory of each director's strengths to ensure that the group as a whole possesses the skills necessary to do its work. Directors must exert more influence over meeting agendas and make sure they have the right information at the right time and in the right format to perform their duties. Finally, the board needs to foster an engaged culture characterized by candor and a willingness to challenge. An ambitious board-building process, devised and endorsed both by directors and by management, can potentially turn a good board into a great one. PMID:15146740

  7. Building better boards.

    Science.gov (United States)

    Nadler, David A

    2004-05-01

    Companies facing new requirements for governance are scrambling to buttress financial-reporting systems, overhaul board structures--whatever it takes to comply. But there are limits to how much good governance can be imposed from the outside. Boards know what they ought to be: seats of challenge and inquiry that add value without meddling and make CEOs more effective but not all-powerful. A board can reach that goal only if it functions as a high-performance team, one that is competent, coordinated, collegial, and focused on an unambiguous goal. Such entities don't just evolve; they must be constructed to an exacting blueprint--what the author calls board building. In this article, Nadler offers an agenda and a set of tools that boards can use to define and achieve their objectives. It's important for a board to conduct regular self-assessments and to pay attention to the results of those analyses. As a first step, the directors and the CEO should agree on which of the following common board models best fits the company: passive, certifying, engaged, intervening, or operating. The directors and the CEO should then analyze which business tasks are most important and allot sufficient time and resources to them. Next, the board should take inventory of each director's strengths to ensure that the group as a whole possesses the skills necessary to do its work. Directors must exert more influence over meeting agendas and make sure they have the right information at the right time and in the right format to perform their duties. Finally, the board needs to foster an engaged culture characterized by candor and a willingness to challenge. An ambitious board-building process, devised and endorsed both by directors and by management, can potentially turn a good board into a great one.

  8. Sustainability in Energy and Buildings

    OpenAIRE

    Kinnane, Oliver; Basu, Biswajit

    2014-01-01

    PUBLISHED Cardiff This paper presents a new methodology for characterising the energy performance of buildings suitable for city-scale, top-down energy modelling. Building properties that have the greatest impact on simulated energy performance were identified via a review of sensitivity analysis studies. The methodology greatly simplifies the description of a building to decrease labour and simulation processing overheads. The methodology will be used in the EU FP7 INDICATE project whi...

  9. Building Integration of Aerogel Glazings

    OpenAIRE

    Gao, Tao; Jelle, Bjørn Petter; Gustavsen, Arild

    2016-01-01

    The recent building practices have shown that aerogel glazings can be used as a multifunctional building envelope component for different purposes. Nevertheless, the distinctive physical properties and energy performance of aerogel glazings suggest that building integration of aerogel glazings may create architectural challenges, aesthetic problems, as well as concerns on their durability and environmental impact, thus highlighting the importance of developing guidelines to regulate the use o...

  10. Energy-efficient timber buildings

    OpenAIRE

    Zbašnik-Senegačnik, Martina; Kitek Kuzman, Manja

    2015-01-01

    The choice of materials for a building with high energy efficiency becomes much more important and strategies for reducing the use of primary energy for the production of materials and components becomes key. The positive trend towards wooden construction is dictated by international guidelines, where a wooden building is an important starting point, not only for low-energy, but also low-emission building with exceptional health and safety aspects. In Europe, the most comprehensiv...

  11. Guidelines on Building Regulations 2008

    DEFF Research Database (Denmark)

    Thse guidelines clarify and intepret the provisions of the Building Regulations of 2008 (BR08). The Guidelines, which match BR08 in terms of organisation into Parts, are accompanied by the full text of the regulations and the explanatory notes issued by the Danish Enterprise and Construction...... climate, energy consumotion and services. The Guidelines are aimed at all professionals involved in building projects, particularly building design consultants, contractors and municipal application officers....

  12. Descent in buildings (AM-190)

    CERN Document Server

    Mühlherr, Bernhard; Weiss, Richard M

    2015-01-01

    Descent in Buildings begins with the resolution of a major open question about the local structure of Bruhat-Tits buildings. The authors then put their algebraic solution into a geometric context by developing a general fixed point theory for groups acting on buildings of arbitrary type, giving necessary and sufficient conditions for the residues fixed by a group to form a kind of subbuilding or "form" of the original building. At the center of this theory is the notion of a Tits index, a combinatorial version of the notion of an index in the relative theory of algebraic groups. These results

  13. Electric Propulsion Research Building (EPRB)

    Data.gov (United States)

    Federal Laboratory Consortium — The Electric Propulsion Research Building (EPRB) capability centers on its suite of vacuum chambers, which are configured to meet the unique requirements related to...

  14. Lifetime environmental impact of buildings

    CERN Document Server

    Mequignon, Marc

    2014-01-01

    This work discusses the impact of the life of buildings on? sustainable development methods.?The study of the lifespan of the building is used to assess and?manage the environmental impacts associated?with all the stages of a product's life, from raw material extraction?through to repair, maintenance and?? 'end of life' scenarios. While several papers have discussed thegreenhouse gas emissions of buildings,?less research has been done on how these are affected by the lifespan?of the building. This book serves to?highlight the pertinence of this factor and contributes to providing?new ideas on

  15. Building Energy Monitoring and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Tianzhen; Feng, Wei; Lu, Alison; Xia, Jianjun; Yang, Le; Shen, Qi; Im, Piljae; Bhandari, Mahabir

    2013-06-01

    U.S. and China are the world’s top two economics. Together they consumed one-third of the world’s primary energy. It is an unprecedented opportunity and challenge for governments, researchers and industries in both countries to join together to address energy issues and global climate change. Such joint collaboration has huge potential in creating new jobs in energy technologies and services. Buildings in the US and China consumed about 40% and 25% of the primary energy in both countries in 2010 respectively. Worldwide, the building sector is the largest contributor to the greenhouse gas emission. Better understanding and improving the energy performance of buildings is a critical step towards sustainable development and mitigation of global climate change. This project aimed to develop a standard methodology for building energy data definition, collection, presentation, and analysis; apply the developed methods to a standardized energy monitoring platform, including hardware and software, to collect and analyze building energy use data; and compile offline statistical data and online real-time data in both countries for fully understanding the current status of building energy use. This helps decode the driving forces behind the discrepancy of building energy use between the two countries; identify gaps and deficiencies of current building energy monitoring, data collection, and analysis; and create knowledge and tools to collect and analyze good building energy data to provide valuable and actionable information for key stakeholders.

  16. Energy Innovations for Healthy Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Bogucz, Edward A. [Syracuse Univ., NY (United States)

    2016-09-23

    Healthy buildings provide high indoor environmental quality for occupants while simultaneously reducing energy consumption. This project advanced the development and marketability of envisioned healthy, energy-efficient buildings through studies that evaluated the use of emerging technologies in commercial and residential buildings. The project also provided resources required for homebuilders to participate in DOE’s Builders Challenge, concomitant with the goal to reduce energy consumption in homes by at least 30% as a first step toward achieving envisioned widespread availability of net-zero energy homes by 2030. In addition, the project included outreach and education concerning energy efficiency in buildings.

  17. Building guide : how to build Xyce from source code.

    Energy Technology Data Exchange (ETDEWEB)

    Keiter, Eric Richard; Russo, Thomas V.; Schiek, Richard Louis; Sholander, Peter E.; Thornquist, Heidi K.; Mei, Ting; Verley, Jason C.

    2013-08-01

    While Xyce uses the Autoconf and Automake system to configure builds, it is often necessary to perform more than the customary %E2%80%9C./configure%E2%80%9D builds many open source users have come to expect. This document describes the steps needed to get Xyce built on a number of common platforms.

  18. Digital Handover of Data from Building Projects to Building Operation

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2006-01-01

    and construction and on the other side in building opera-tion and facilities management. In Denmark the government has launched a development program called Digital Construction and one of the projects concerns specifying require-ments for building clients in relation to digital handover of data from construction...

  19. Building envelope for New Buildings and Energy Renovation of Existing Buildings. Project results

    DEFF Research Database (Denmark)

    Rudbeck, Claus Christian; Rose, Jørgen; Esbensen, Peter Kjær;

    1999-01-01

    , a group of scientists at the Department of Buildings and Energy, Technical University of Denmark, have started a research project to develop better solutions for new building and energy renovation.The publication report the status after the first 3 year of the Building Envelope Project with emphasis......At the energy conference in 1995, Denmark agreed on reducing the total CO2-emission by 20%. To achieve this goal, it is necessary to increase thermal insulation thickness both in new and retrofitted buildings.This will, for both cases, impose a series of building physics problems, as the knowledge...... on the following subjects:Scientific basis for calculation programs, Development of calculationsmethods for heat transfer, Development of new building envelope components, Roofing system based on wooden roof elements, Roofing system with drying properties, Moisture uptake and drying from brick constructions...

  20. Construction achievements at building in reprocessing plant

    International Nuclear Information System (INIS)

    We have constructed simultaneously four buildings, AB building, DB building, DC building, and KA building in the spent nuclear fuel reprocessing plant at Rokkasho village in Aomori. We were able to complete the massive and complicated building in the highest quality by the method of prefabrication of site work in a short construction term. Moreover, also in the severe winter season, we practiced construction work intentionally. Consequently, we completed three buildings, AB building, DB building, and DC building without the trouble last year. (author)

  1. Virtual building environments (VBE) - Applying information modeling to buildings

    Energy Technology Data Exchange (ETDEWEB)

    Bazjanac, Vladimir

    2004-06-21

    A Virtual Building Environment (VBE) is a ''place'' where building industry project staffs can get help in creating Building Information Models (BIM) and in the use of virtual buildings. It consists of a group of industry software that is operated by industry experts who are also experts in the use of that software. The purpose of a VBE is to facilitate expert use of appropriate software applications in conjunction with each other to efficiently support multidisciplinary work. This paper defines BIM and virtual buildings, and describes VBE objectives, set-up and characteristics of operation. It informs about the VBE Initiative and the benefits from a couple of early VBE projects.

  2. INL High Performance Building Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer D. Morton

    2010-02-01

    High performance buildings, also known as sustainable buildings and green buildings, are resource efficient structures that minimize the impact on the environment by using less energy and water, reduce solid waste and pollutants, and limit the depletion of natural resources while also providing a thermally and visually comfortable working environment that increases productivity for building occupants. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish this mission. This infrastructure, particularly the buildings, should incorporate high performance sustainable design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. Additionally, INL is a large consumer of energy that contributes to both carbon emissions and resource inefficiency. In the current climate of rising energy prices and political pressure for carbon reduction, this guide will help new construction project teams to design facilities that are sustainable and reduce energy costs, thereby reducing carbon emissions. With these concerns in mind, the recommendations described in the INL High Performance Building Strategy (previously called the INL Green Building Strategy) are intended to form the INL foundation for high performance building standards. This revised strategy incorporates the latest federal and DOE orders (Executive Order [EO] 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” [2009], EO 13423, “Strengthening Federal Environmental, Energy, and Transportation Management” [2007], and DOE Order 430.2B, “Departmental Energy, Renewable Energy, and Transportation Management” [2008]), the latest guidelines, trends, and observations in high performance building construction, and the latest changes to the Leadership in Energy and Environmental Design

  3. Towards more Manageable Coastal Building; Initial Coastal Building Construction Guidelines

    Directory of Open Access Journals (Sweden)

    Roslan Talib

    2011-01-01

    Full Text Available Problem statement: As we may not be aware that the coastal construction is different from inland construction. Building in a coastal environment is different from building in an inland area. In general, buildings in coastal areas must be designed and built to withstand higher loads due to its more extreme conditions. Nowadays, the issue of global warming, uncertainty of global weather and the climate change effect indirectly creating the coastal area with much more expose to extreme condition. Formulate initial guidelines with certain degree of details how coastal construction requirements are different from those for inland construction. Approach: Due to the exposure to higher loads and extreme conditions, these structures in coastal areas will cost more to design, construct, maintain, repair and insure. Proper and right usage of building materials including electrical and mechanical equipments, are crucial in order to minimize damage. Nowadays, the issue of global warming, uncertainty of global weather and the climate change effect indirectly creating the coastal area with much more expose to extreme condition. Feedback has been gathered from the government local engineers who are doing the management of the Government’s local buildings located along the coastal area of Peninsular Malaysia. Data findings through research method, discussion with the suppliers and discussion with coastal buildings maintenance crews also has been done. Results: The research finding discus the specific characteristics that makes for successful coastal buildings focusing in tropical region. Conclusion: We must accept on the idea of building in coastal areas will require more maintenance and upkeep. By having proper coastal building guideline may create more positive awareness in constructing better management coastal buildings and can save time and money to maintain the said structures.

  4. Capacity building for HIA

    Directory of Open Access Journals (Sweden)

    Gabriel Gulis PhD

    2007-09-01

    Full Text Available

    Background: To integrate health impact assessment (HIA into existing decision-making processes requires not only methods and procedures but also well-trained experts, aware policy makers and appropriate institutions. Capacity building is the assistance which is provided to entities, which have a need to develop a certain skill or competence, or for general upgrading of performance ability. If a new technique is planned to be introduced there is a need for capacity building with no respect to levels (local, regional, national, international or sectors (health, environment, finance, social care, education, etc.. As such, HIA is a new technique for most of the new Member States and accession countries of the European Union.

    Methods: To equip individuals with the understanding and skills needed to launch a HIA or be aware of the availability of this methodology and to access information, knowledge and training, we focused on the organization of workshops in participating countries. The workshops served also as pilot events to test a “curriculum” for HIA; a set of basic topics and presentations had been developed to be tested during workshops. In spite of classical in-class workshops we aimed to organize e-learning events as a way to over come the “busyness” problem of decision makers.

    Results: Throughout March – October 2006 we organized and ran 7 workshops in Denmark, Turkey, Lithuania, Poland, Bulgaria, Slovak Republic and Hungary. Participants came from the public health sector (141, non-public health decision makers (113 and public health students (100. A concise curriculum was developed and tested during these workshops. Participants developed a basic understanding of HIA, skills to develop and use their own screening tools as well as scoping.Within the workshop in Denmark we tested an online, real-time Internet based training method; participants highly welcomed this

  5. Maintenance Planning for Historic Buildings

    OpenAIRE

    Diana Plian; Dan Babor

    2008-01-01

    The key to good maintenance of historic buildings is a long-range maintenance plan. Long-range planning recognizes a responsibility to the future to prolong the useful life of a building by preserving it in its present condition and preventing or slowing deterioration and damage from natural or other causes.

  6. Energy efficiency of building envelope

    OpenAIRE

    V.M. Yakubson

    2014-01-01

    November, 12-13th, in Saint-Petersburg the 7th International congress "Energy efficiency. XXI century" took place. The reports were done in breakuo groups according to the various aspects of energy efficiency challenge: HVAC systems, water supply and sewerage systems, gas supply, energy metering. One of the grourps was devoted to thermophysics of buildings and energy effective design of building envelope.

  7. Building Blocks for Personal Brands

    Science.gov (United States)

    Thomas, Lisa Carlucci

    2011-01-01

    In this article, the author discusses the four essential building blocks for personal brands: (1) name; (2) message; (3) channels; and (4) bridges. However, outstanding building materials can only take a person so far. The author emphasizes that vision, determination, faith, a sense of humor, and humility are also required.

  8. To Remodel or To Build?

    Science.gov (United States)

    Rosenblum, Todd

    2009-01-01

    The question of remodeling an existing house to make it wheelchair accessible or building a new barrier-free house is a difficult decision. This article presents some initial questions and considerations followed by a list of pros and cons for remodeling an existing house vs. building a new house.

  9. Building Bounce-Back Kids

    Science.gov (United States)

    Lloyd-Zannini, Lou

    2011-01-01

    In this article, the author talks about building resilience--that ability to push through hardship to success, to rebound from failure, and to "keep on keepin' on" when things seem impossible. The author assert that lots of gifted and talented kids need help building their resilience. In today's world, when striving for mediocrity can seem like…

  10. IN SPHERE OF ROAD BUILDING

    Directory of Open Access Journals (Sweden)

    Shakhov Oleg Fedorovich

    2012-09-01

    Full Text Available At present, it is necessary to use concession bases of development of national transport systems more widely considering the importance of road building, and also that fact that interests of the state and managing subjects - participants of investment building activity have differently directed vectors.

  11. Federal Buildings Supplemental Survey 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The Energy Information Administration (EIA) of the US Department of Energy (DOE) is mandated by Congress to be the agency that collects, analyzes, and disseminates impartial, comprehensive data about energy including the volume consumed, its customers, and the purposes for which it is used. The Federal Buildings Supplemental Survey (FBSS) was conducted by EIA in conjunction with DOE`s Office of Federal Energy Management Programs (OFEMP) to gain a better understanding of how Federal buildings use energy. This report presents the data from 881 completed telephone interviews with Federal buildings in three Federal regions. These buildings were systematically selected using OFEMP`s specifications; therefore, these data do not statistically represent all Federal buildings in the country. The purpose of the FBSS was threefold: (1) to understand the characteristics of Federal buildings and their energy use; (2) to provide a baseline in these three Federal regions to measure future energy use in Federal buildings as required in EPACT; and (3) to compare building characteristics and energy use with the data collected in the CBECS.

  12. Mould growth on building materials

    DEFF Research Database (Denmark)

    Fog Nielsen, K.

    Mould growth in buildings is associated with adverse health effects among the occupants of the building. However actual growth only occurs in damp and water-damaged materials, and is an increasing problem in Denmark, due to less robust constructions, inadequate maintenance, and too little...

  13. Simulating Building Fires for Movies

    Science.gov (United States)

    Rodriguez, Ricardo C.; Johnson, Randall P.

    1987-01-01

    Fire scenes for cinematography staged at relatively low cost in method that combines several existing techniques. Nearly realistic scenes, suitable for firefighter training, produced with little specialized equipment. Sequences of scenes set up quickly and easily, without compromising safety because model not burned. Images of fire, steam, and smoke superimposed on image of building to simulate burning of building.

  14. Biogas building directions

    Energy Technology Data Exchange (ETDEWEB)

    Eggeling, G.; Guldager, R.; Hilliges, G.; Tietjen, C.; Werner, U.; Guldager, H.; Sasse, L.

    The purpose of this book is to approach the people living and working in the rural regions of developing countries with a technology enabling them to use their resources by their proper means in a way that they dispose of a cheap and inexhaustible source of energy and fertilizer. These building directives for biogas plants shall concretely give the fundamental information for the use of this technology and be a practical support in do-it-yourself construction of biogas plants by its intelligible way of description owing to designs and popular language. These directives are part of a work performed by German and Indian experts during two years working up the biogas technology in countries of the Third World and in industrial countries. The regulations have been discussed at an international workshop in Bremen with more than 60 experts from countries of all continents meeting to discuss the application of biogas plants. The result has been documented in the ''Report on the International Biogas-Workshop Bremen''.

  15. Building an innovation factory.

    Science.gov (United States)

    Hargadon, A; Sutton, R I

    2000-01-01

    New ideas are the precious currency of the new economy, but generating them doesn't have to be a mysterious process. The image of the lone genius inventing from scratch is a romantic fiction. Businesses that constantly innovate have systematized the production and testing of new ideas, and the system can be replicated by practically any organization. The best innovators use old ideas as the raw materials for new ideas, a strategy the authors call knowledge brokering. The system for sustaining innovation is the knowledge brokering cycle, and the authors discuss its four parts. The first is capturing good ideas from a wide variety of sources. The second is keeping those ideas alive by playing with them, discussing them, and using them. Imagining new uses for old ideas is the third part--some knowledge brokers encourage cross-pollination by creating physical layouts that allow, or even force, people to interact with one another. The fourth is turning promising concepts into real services, products, processes, or business models. Companies can use all or part of the cycle. Large companies in particular desperately need to move ideas from one place to another. Some will want to build full-fledged consulting groups dedicated to internal knowledge brokering. Others can hire people who have faced problems similar to the companies' current problems. The most important lesson is that business leaders must change how they think about innovation, and they must change how their company cultures reflect that thinking. PMID:11183977

  16. Nuclear reactor building

    Science.gov (United States)

    Gou, Perng-Fei; Townsend, Harold E.; Barbanti, Giancarlo

    1994-01-01

    A reactor building for enclosing a nuclear reactor includes a containment vessel having a wetwell disposed therein. The wetwell includes inner and outer walls, a floor, and a roof defining a wetwell pool and a suppression chamber disposed thereabove. The wetwell and containment vessel define a drywell surrounding the reactor. A plurality of vents are disposed in the wetwell pool in flow communication with the drywell for channeling into the wetwell pool steam released in the drywell from the reactor during a LOCA for example, for condensing the steam. A shell is disposed inside the wetwell and extends into the wetwell pool to define a dry gap devoid of wetwell water and disposed in flow communication with the suppression chamber. In a preferred embodiment, the wetwell roof is in the form of a slab disposed on spaced apart support beams which define therebetween an auxiliary chamber. The dry gap, and additionally the auxiliary chamber, provide increased volume to the suppression chamber for improving pressure margin.

  17. Strengthening Building Retrofit Markets

    Energy Technology Data Exchange (ETDEWEB)

    Templeton, Mary [Michigan Saves; Jackson, Robert [Michigan Energy Office

    2014-04-15

    The Business Energy Financing (BEF) program offered commercial businesses in Michigan affordable financing options and other incentives designed to support energy efficiency improvements. We worked through partnerships with Michigan utilities, lenders, building contractors, trade associations, and other community organizations to offer competitive interest rates and flexible financing terms to support energy efficiency projects that otherwise would not have happened. The BEF program targeted the retail food market, including restaurants, grocery stores, convenience stores, and wholesale food vendors, with the goal of achieving energy efficiency retrofits for 2 percent of the target market. We offered low interest rates, flexible payments, easy applications and approval processes, and access to other incentives and rebates. Through these efforts, we sought to help customers strive for energy savings retrofits that would save 20 percent or more on their energy use. This program helped Michigan businesses reduce costs by financing energy efficient lighting, heating and cooling systems, insulation, refrigeration, equipment upgrades, and more. Businesses completed the upgrades with the help of our authorized contractors, and, through our lending partners, we provided affordable financing options.

  18. Building a crystal palace

    CERN Multimedia

    2007-01-01

    The end-caps of the CMS electromagnetic calorimeter (ECAL) take shape as the first quadrant was completed on Wednesday 3 October. 1831 crystals, organised into five by five blocks named ‘supercrystals’, make up the first quadrant of Dee 1.With the 61,200-crystal barrel of its electromagnetic calorimeter (ECAL) complete, CMS is now building the endcaps, on the tenth anniversary of their initial design. Crystals for the endcaps were the last to be made, so the race is now on to have them all in place and ready for the turn-on of the LHC next year. Assembly of the first of eight quadrants began in June and crystal mounting was completed on Wednesday 3 October. Each crystal is transparent, has a volume just larger than a CERN coffee cup yet weighs a huge 1.5kg. 1831 of these lead tungstate crystals went into the first quadrant from a total 14,648 in the endcaps. The lead and tungsten account for 86% of each crystal’s weight, but as project leader Dave Cockerill expl...

  19. Integrating Environmentally Responsive Elements in Buildings

    OpenAIRE

    Heiselberg, Per; Andresen, Inger; Perino, Marco; van der Aa, Ad

    2006-01-01

    Significant improvement have been achieved on efficiency improvements of specific building elements like the building envelope and building equipment and services and whilst most building elements still offer opportunities for efficiency improvements, the greatest future potential lie with technologies that promote the integration of responsive building elements and building services in integrated building concepts. In order to address some of these issues an international research effort, IE...

  20. California commercial building energy benchmarking

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, Satkartar; Piette, Mary Ann

    2003-07-01

    Building energy benchmarking is the comparison of whole-building energy use relative to a set of similar buildings. It provides a useful starting point for individual energy audits and for targeting buildings for energy-saving measures in multiple-site audits. Benchmarking is of interest and practical use to a number of groups. Energy service companies and performance contractors communicate energy savings potential with ''typical'' and ''best-practice'' benchmarks while control companies and utilities can provide direct tracking of energy use and combine data from multiple buildings. Benchmarking is also useful in the design stage of a new building or retrofit to determine if a design is relatively efficient. Energy managers and building owners have an ongoing interest in comparing energy performance to others. Large corporations, schools, and government agencies with numerous facilities also use benchmarking methods to compare their buildings to each other. The primary goal of Task 2.1.1 Web-based Benchmarking was the development of a web-based benchmarking tool, dubbed Cal-Arch, for benchmarking energy use in California commercial buildings. While there were several other benchmarking tools available to California consumers prior to the development of Cal-Arch, there were none that were based solely on California data. Most available benchmarking information, including the Energy Star performance rating, were developed using DOE's Commercial Building Energy Consumption Survey (CBECS), which does not provide state-level data. Each database and tool has advantages as well as limitations, such as the number of buildings and the coverage by type, climate regions and end uses. There is considerable commercial interest in benchmarking because it provides an inexpensive method of screening buildings for tune-ups and retrofits. However, private companies who collect and manage consumption data are concerned that the

  1. Data management for biofied building

    Science.gov (United States)

    Matsuura, Kohta; Mita, Akira

    2015-03-01

    Recently, Smart houses have been studied by many researchers to satisfy individual demands of residents. However, they are not feasible yet as they are very costly and require many sensors to be embedded into houses. Therefore, we suggest "Biofied Building". In Biofied Building, sensor agent robots conduct sensing, actuation, and control in their house. The robots monitor many parameters of human lives such as walking postures and emotion continuously. In this paper, a prototype network system and a data model for practical application for Biofied Building is pro-posed. In the system, functions of robots and servers are divided according to service flows in Biofield Buildings. The data model is designed to accumulate both the building data and the residents' data. Data sent from the robots and data analyzed in the servers are automatically registered into the database. Lastly, feasibility of this system is verified through lighting control simulation performed in an office space.

  2. Integrated Building Management System (IBMS)

    Energy Technology Data Exchange (ETDEWEB)

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  3. Capacity Building in Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig; Williamson, I

    2004-01-01

    Capacity building increasingly seen as a key component of land administration projects in developing and countries in transition undertaken by the international development banks and individual country development assistance agencies. However, the capacity building concept is often used within...... infrastructures for implementing land policies in a sustainable way. Where a project is established to create land administration infrastructures in developing or transition countries, it is critical that capacity building is a mainstream component, not as an add-on, which is often the case. In fact such projects...... should be dealt with as capacity building projects in themselves.    The article introduces a conceptual analytical framework that provides some guidance when dealing with capacity building for land administration in support of a broader land policy agenda....

  4. Tropical Zero Energy Office Building

    DEFF Research Database (Denmark)

    Reimann, Gregers Peter; Kristensen, Poul Erik

    2006-01-01

    The new headquarter for Pusat Tenaga Malaysia is designed to be a Zero Emission Office Building (ZEO). A full range of passive and active energy efficiency measures are implemented such that the building will need no more electricity than what can be produced via its own Building Integrated PV...... by daylight, supplemented by electric lighting during very dark and overcast periods. Extensive active energy efficiency measures are implemented in the building in order to reduce the need for electricity to an absolute minimum, without compromising the request for comfortable temperatures and adequate...... lighting. These measures include the use of high efficient lighting controlled according to demand, high efficiency pumps and fans, a high efficiency chiller, and use of energy efficient office equipment. The buildings PV system is connected to the grid. Solar electricity is exported to the grid during...

  5. 327 Building hazard baseline document

    International Nuclear Information System (INIS)

    This document identifies the hazards in the 327 Building at the time that a facility walk through was performed during FY99, presents a PHA of stabilization and deactivation activities, and provides a basis for the hazard evaluation and accident analysis that will be developed in the 327 Building Basis for Interim Operation (BIO). Activities addressed in this hazard baseline document include: (1) Stabilization and deactivation activities in preparation for eventual decommissioning of the 327 Building and the routine handling, processing, and shipment of waste to support these activities. (2) 324/327 Building Minimum Safe Project engineering and maintenance activities to maintain the building and systems viable--especially the Safety SSCs--to allow stabilization, deactivation, and waste handling activities with a minimum of risk to workers, the public, and the environment

  6. Building America Expert Meeting Report: Hydronic Heating in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, J.

    2011-10-01

    The topic of this expert meeting was cost-effective controls and distribution retrofit options for hot water and steam space heating systems in multi-family buildings with the goals of reducing energy waste and improving occupant comfort. The U.S. Department of Energy's Building America program develops technologies with the goal of reducing energy use by 30% to 50% in residential buildings. Toward this goal, the program sponsors 'Expert Meetings' focused on specific building technology topics. The meetings are intended to sharpen Building America research priorities, create a forum for sharing information among industry leaders and build partnerships with professionals and others that can help support the program's research needs and objectives. The topic of this expert meeting was cost-effective controls and distribution retrofit options for hot water and steam space heating systems in multifamily buildings with the goals of reducing energy waste and improving occupant comfort. The objectives of the meeting were to: (1) Share knowledge and experience on new and existing solutions: what works, what doesn't and why, and what's new; (2) Understand the market barriers to currently offered solutions: what disconnects exist in the market and what is needed to overcome or bridge these gaps; and (3) Identify research needs.

  7. Energy use in office buildings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    This is the report on Task IB, Familiarization with Additional Data Collection Plans of Annual Survey of BOMA Member and Non-Member Buildings in 20 Cities, of the Energy Use in Office Buildings project. The purpose of the work was to monitor and understand the efforts of the Building Owners and Managers Association International (BOMA) in gathering an energy-use-oriented data base. In order to obtain an improved data base encompassing a broad spectrum of office space and with information suitable for energy analysis in greater detail than is currently available, BOMA undertook a major data-collection effort. Based on a consideration of geographic area, climate, population, and availability of data, BOMA selected twenty cities for data collection. BOMA listed all of the major office space - buildings in excess of 40,000 square feet - in each of the cities. Tax-assessment records, local maps, Chamber of Commerce data, recent industrial-development programs, results of related studies, and local-realtor input were used in an effort to assemble a comprehensive office-building inventory. In order to verify the accuracy and completeness of the building lists, BOMA assembled an Ad-Hoc Review Committee in each city to review the assembled inventory of space. A questionnaire on office-building energy use and building characteristics was developed. In each city BOMA assembled a data collection team operating under the supervision of its regional affiliate to gather the data. For each city a random sample of buildings was selected, and data were gathered. Responses for over 1000 buildings were obtained.

  8. Energy Efficiency Building Code for Commercial Buildings in Sri Lanka

    International Nuclear Information System (INIS)

    1.1.1 To encourage energy efficient design or retrofit of commercial buildings so that they may be constructed, operated, and maintained in a manner that reduces the use of energy without constraining the building function, the comfort, health, or the productivity of the occupants and with appropriate regard for economic considerations. 1.1.2 To provide criterion and minimum standards for energy efficiency in the design or retrofit of commercial buildings and provide methods for determining compliance with them. 1.1.3 To encourage energy efficient designs that exceed these criterion and minimum standards

  9. Energy Efficiency Building Code for Commercial Buildings in Sri Lanka

    Energy Technology Data Exchange (ETDEWEB)

    Busch, John; Greenberg, Steve; Rubinstein, Francis; Denver, Andrea; Rawner, Esther; Franconi, Ellen; Huang, Joe; Neils, Danielle

    2000-09-30

    1.1.1 To encourage energy efficient design or retrofit of commercial buildings so that they may be constructed, operated, and maintained in a manner that reduces the use of energy without constraining the building function, the comfort, health, or the productivity of the occupants and with appropriate regard for economic considerations. 1.1.2 To provide criterion and minimum standards for energy efficiency in the design or retrofit of commercial buildings and provide methods for determining compliance with them. 1.1.3 To encourage energy efficient designs that exceed these criterion and minimum standards.

  10. Better Buildings Neighborhood Program: BetterBuildings Lowell Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Heslin, Thomas

    2014-01-31

    The City of Lowell set four goals at the beginning of the Better Buildings Neighborhood Program: 1. Improve the Downtown Historic Park District’s Carbon Footprint 2. Develop a sustainable and replicable model for energy efficiency in historic buildings 3. Create and retain jobs 4. Promote multi-stakeholder partnerships The City of Lowell, MA was awarded $5 million in May 2010 to conduct energy efficiency retrofits within the downtown National Historical Park (NHP). The City’s target was to complete retrofits in 200,000 square feet of commercial space and create 280 jobs, while adhering to the strict historical preservation regulations that govern the NHP. The development of a model for energy efficiency in historic buildings was successfully accomplished. BetterBuildings Lowell’s success in energy efficiency in historic buildings was due to the simplicity of the program. We relied strongly on the replacement of antiquated HVAC systems and air sealing and a handful of talented energy auditors and contractors. BetterBuildings Lowell was unique for the Better Buildings Neighborhood Program because it was the only program that focused solely on commercial properties. BetterBuildings Lowell did target multi-family properties, which were reported as commercial, but the majority of the building types and uses were commercial. Property types targeted were restaurants, office buildings, museums, sections of larger buildings, mixed use buildings, and multifamily buildings. This unique fabric of building type and use allows for a deeper understanding to how different properties use energy. Because of the National Historical Park designation of downtown Lowell, being able to implement energy efficiency projects within a highly regulated historical district also provided valuable research and precedent proving energy efficiency projects can be successfully completed in historical districts and historical buildings. Our program was very successful in working with the local

  11. NASA, Building Tomorrow's Future

    Science.gov (United States)

    Mango, Edward

    2011-01-01

    We, as NASA, continue to Dare Mighty Things. Here we are in October. In my country, the United States of America, we celebrate the anniversary of Christopher Columbus's arrival in the Americas, which occurred on October 12, 1492. His story, although happening over 500 years ago, is still very valid today. It is a part of the American spirit; part of the international human spirit. Columbus is famous for discovering the new world we now call America, but he probably never envisioned what great discoveries would be revealed many generations later. But in order for Columbus to begin his great adventure, he needed a business plan. Ho would he go about obtaining the funds and support necessary to build, supply, and man the ships required for his travels? He had a lot of obstacles and distractions. He needed a strong, internal drive to achieve his plans and recruit a willing crew of explorers also ready to risk their all for the unknown journey ahead. As Columbus set sail, he said "By prevailing over all obstacles and distractions, one may unfailingly arrive at his chosen goal or destination." Columbus may not have known he was on a journey for all human exploration. Recently, Charlie Bolden, the NASA Administrator, said, "Human exploration is and has always been about making life better for humans on Earth." Today, NASA and the U.S. human spaceflight program hold many of the same attributes as did Columbus and his contemporaries - a willing, can-do spirit. We are on the threshold of exciting new times in space exploration. Like Columbus, we need a business plan to take us into the future. We need to design the best ships and utilize the best designers, with their past knowledge and experience, to build those ships. We need funding and support from governments to achieve these goals of space exploration into the unknown. NASA does have that business plan, and it is an ambitious plan for human spaceflight and exploration. Today, we have a magnificent spaceflight

  12. BUILDING MATERIALS RECLAMATION PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    David C. Weggel; Shen-En Chen; Helene Hilger; Fabien Besnard; Tara Cavalline; Brett Tempest; Adam Alvey; Madeleine Grimmer; Rebecca Turner

    2010-08-31

    This report describes work conducted on the Building Materials Reclamation Program for the period of September 2008 to August 2010. The goals of the project included selecting materials from the local construction and demolition (C&D) waste stream and developing economically viable reprocessing, reuse or recycling schemes to divert them from landfill storage. Educational resources as well as conceptual designs and engineering feasibility demonstrations were provided for various aspects of the work. The project was divided into two distinct phases: Research and Engineering Feasibility and Dissemination. In the Research Phase, a literature review was initiated and data collection commenced, an advisory panel was organized, and research was conducted to evaluate high volume C&D materials for nontraditional use; five materials were selected for more detailed investigations. In the Engineering Feasibility and Dissemination Phase, a conceptual study for a regional (Mecklenburg and surrounding counties) collection and sorting facility was performed, an engineering feasibility project to demonstrate the viability of recycling or reuse schemes was created, the literature review was extended and completed, and pedagogical materials were developed. Over the two-year duration of the project, all of the tasks and subtasks outlined in the original project proposal have been completed. The Final Progress Report, which briefly describes actual project accomplishments versus the tasks/subtasks of the original project proposal, is included in Appendix A of this report. This report describes the scientific/technical aspects (hypotheses, research/testing, and findings) of six subprojects that investigated five common C&D materials. Table 1 summarizes the six subprojects, including the C&D material studied and the graduate student and the faculty advisor on each subproject.

  13. Building Materials Reclamation Program

    International Nuclear Information System (INIS)

    This report describes work conducted on the Building Materials Reclamation Program for the period of September 2008 to August 2010. The goals of the project included selecting materials from the local construction and demolition (C and D) waste stream and developing economically viable reprocessing, reuse or recycling schemes to divert them from landfill storage. Educational resources as well as conceptual designs and engineering feasibility demonstrations were provided for various aspects of the work. The project was divided into two distinct phases: Research and Engineering Feasibility and Dissemination. In the Research Phase, a literature review was initiated and data collection commenced, an advisory panel was organized, and research was conducted to evaluate high volume C and D materials for nontraditional use; five materials were selected for more detailed investigations. In the Engineering Feasibility and Dissemination Phase, a conceptual study for a regional (Mecklenburg and surrounding counties) collection and sorting facility was performed, an engineering feasibility project to demonstrate the viability of recycling or reuse schemes was created, the literature review was extended and completed, and pedagogical materials were developed. Over the two-year duration of the project, all of the tasks and subtasks outlined in the original project proposal have been completed. The Final Progress Report, which briefly describes actual project accomplishments versus the tasks/subtasks of the original project proposal, is included in Appendix A of this report. This report describes the scientific/technical aspects (hypotheses, research/testing, and findings) of six subprojects that investigated five common C and D materials. Table 1 summarizes the six subprojects, including the C and D material studied and the graduate student and the faculty advisor on each subproject.

  14. Building damage in Dujiangyan during Wenchuan Earthquake

    Institute of Scientific and Technical Information of China (English)

    Zhang Minzheng; Jin Yingjie

    2008-01-01

    A field damage survey of 1,005 buildings damaged by the Wenchuan Earthquake in Dujiangyan City was carried out and the resulting data was analyzed using the statistical method. It is shown that buildings that were seismically designed achieved the desired seismic fortification target; they sustained less damage than the non-seismically designed buildings. Among the seismically designed buildings investigated, RC frame buildings performed the best in terms of seismic resistance. Masonry buildings with a ground story of RC frame structure were the second best, and masonry buildings performed the worst. Considering building height, multistory buildings sustained more severe damage than high-rise buildings and 2-and 3-story buildings. Compared to residential buildings, public buildings, such as schools and hospitals, suffered more severe damage.

  15. Energy efficiency buildings program, FY 1980

    Energy Technology Data Exchange (ETDEWEB)

    1981-05-01

    A separate abstract was prepared on research progress in each group at LBL in the energy efficient buildings program. Two separate abstracts were prepared for the Windows and Lighting Program. Abstracts prepared on other programs are: Energy Performance of Buildings; Building Ventilation and Indoor Air Quality Program; DOE-21 Building Energy Analysis; and Building Energy Data Compilation, Analysis, and Demonstration. (MCW)

  16. Building 774: open for business

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    In July 2012, the demolition of Building 936 on the Prévessin site marked the start of the Building 774 project. On 23 February, less than three years later, the new 3900 m2 building was handed over to the BE department.   The brand new Building 774. (Credits: Francesco Soppelsa) Located near to the CERN Control Centre, Building 774 contains offices, laboratories and meeting rooms, as well as a huge public area consisting of a 104-seat auditorium, a changing room/shower area in the basement and a pleasant cafeteria open from 8 a.m. to 5 p.m., offering a wide range of refreshments including hot meals at lunchtime. “There were a few twists and turns during the construction of this building, but it all turned out well in the end!" says Michael Poehler, a member of the GS-SE group and the technical coordinator of the project. (Credits: Francesco Soppelsa) The 120 occupants of the building have just moved into their brand new home, bringing all the members of the...

  17. Cognitive Study of Building Metaphor

    Institute of Scientific and Technical Information of China (English)

    牛惠君

    2015-01-01

    Metaphor is a universal phenomenon,the traditional metaphor studies it as a means of rhetoric,but metaphor of modern sees it as a cognitive phenomenon.In our life most of the everyday language is metaphor,our mind is also the metaphor.Meta-phor has become an indispensable tool for understanding the world.There are a lot of “building”metaphorical expressions in the life, construction is an important component of people’s lives. K?vecses (2002)discussed briefly some conceptual metaphors of the construction in English,Deignan (2001)make a compre-hensive study on building metaphors which underlie some metaphor expression of “building and construction”.Lan Chun (2003)only referred to “theory is building”,but the concept of “life,relationships”can be understood through building concept,these relative ab-stract concepts can be understood by clear concrete building concept.Hence the studies of building metaphors have not been systematic and comprehensive,people seldom study it.We plan to give a contrastive study of building metaphors.This will further deepen peo-ple’s understanding of building metaphors and enrich the cognitive studies of metaphor.

  18. Material Efficiency of Building Construction

    Directory of Open Access Journals (Sweden)

    Antti Ruuska

    2014-07-01

    Full Text Available Better construction and use of buildings in the European Union would influence 42% of final energy consumption, about 35% of our greenhouse gas emissions and more than 50% of all extracted materials. It could also help to save up to 30% of water consumption. This paper outlines and draws conclusions about different aspects of the material efficiency of buildings and assesses the significance of different building materials on the material efficiency. The research uses an extensive literature study and a case-study in order to assess: should the depletion of materials be ignored in the environmental or sustainability assessment of buildings, are the related effects on land use, energy use and/or harmful emissions significant, should related indicators (such as GHGs be used to indicate the material efficiency of buildings, and what is the significance of scarce materials, compared to the use of other building materials. This research suggests that the material efficiency should focus on the significant global impacts of material efficiency; not on the individual factors of it. At present global warming and greenhouse gas emissions are among the biggest global problems on which material efficiency has a direct impact on. Therefore, this paper suggests that greenhouse gas emissions could be used as an indicator for material efficiency in building.

  19. Environmental Evaluation of Building Materials of 5 Slovak Buildings

    Science.gov (United States)

    Porhincak, Milan; Estokova, Adriana

    2013-11-01

    Building activity has recently led to the deterioration of environment and has become unsustainable. Several strategies have been introduced in order to minimize consumption of energy and resulting CO2 emissions having their origin in the operational phase. But also other stages of Life Cycle should are important to identify the overall environmental impact of construction sector. In this paper 5 similar Slovak buildings (family houses) were analyzed in terms of environmental performance of building materials used for their structures. Evaluation included the weight of used materials, embodied energy and embodied CO2 and SO2 emissions. Analysis has proven that the selection of building materials is an important factor which influences the environmental profile. Findings of the case study indicated that materials like concrete, ceramic or thermal insulation materials based on polystyrene and mineral wool are ones with the most negative environmental impact.

  20. Buildings-to-Grid Technical Opportunities: From the Buildings Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Piette, Mary Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-03-28

    This paper describes technologies and systems needed to transform buildings from the current state of siloed resources into transparent, reliable resources that participate in and benefit from an integrated "transactive energy" system.

  1. Building Footprints, Building footprints of all building locations in Johnson County, updated off Orthoimarty, Published in unknown, Johnson County AIMS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Building Footprints dataset, was produced all or in part from Orthoimagery information as of unknown. It is described as 'Building footprints of all building...

  2. Toward a virtual building laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Klems, J.H.; Finlayson, E.U.; Olsen, T.H.; Banks, D.W.; Pallis, J.M.

    1999-03-01

    In order to achieve in a timely manner the large energy and dollar savings technically possible through improvements in building energy efficiency, it will be necessary to solve the problem of design failure risk. The most economical method of doing this would be to learn to calculate building performance with sufficient detail, accuracy and reliability to avoid design failure. Existing building simulation models (BSM) are a large step in this direction, but are still not capable of this level of modeling. Developments in computational fluid dynamics (CFD) techniques now allow one to construct a road map from present BSM's to a complete building physical model. The most useful first step is a building interior model (BIM) that would allow prediction of local conditions affecting occupant health and comfort. To provide reliable prediction a BIM must incorporate the correct physical boundary conditions on a building interior. Doing so raises a number of specific technical problems and research questions. The solution of these within a context useful for building research and design is not likely to result from other research on CFD, which is directed toward the solution of different types of problems. A six-step plan for incorporating the correct boundary conditions within the context of the model problem of a large atrium has been outlined. A promising strategy for constructing a BIM is the overset grid technique for representing a building space in a CFD calculation. This technique promises to adapt well to building design and allows a step-by-step approach. A state-of-the-art CFD computer code using this technique has been adapted to the problem and can form the departure point for this research.

  3. Straw insulated buildings. Nature building materials; Strohgedaemmte Gebaeude. Naturbaustoffe

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-01

    Straw is one of the major agricultural by-products and is mainly used as litter in animal husbandry and to compensate the balance of humus. A relatively recent development is the use of straw bales for the construction of buildings. The brochure under consideration documents the technical development of straw construction in Germany. Possibilities of the use of straw in single family homes up to commercial buildings are described.

  4. Energy - efficient buildings in pakistan

    International Nuclear Information System (INIS)

    Pakistan is one of the countries with the highest energy consumption for domestic use. Annual energy consumption by the domestic sector is 45.9 % of the total, while the industrial sector, consumes about 27.5%. About half of the total energy consumed is used in buildings and/or heating, ventilation and air-conditioning (HVAC) and lighting appliances. The energy consumed for the same purposes in China and UK is 25 to 30 % and 40 %, respectively, even in extreme weather conditions. Energy deficiency in Pakistan is approximately 5,000 MWe, which results in worst load-shedding in summers and, lately, even in winters. Building new energy sources like dams, coal power plants and renewable energy power projects are some possible solutions, but these are time taking and need at least 2 to 6 years to complete, depending upon the nature of the project. Fast development of energy-efficient buildings is, therefore, necessary to deal with exacerbating energy-crisis and related environmental impact in Pakistan. Innovations in the prevailing building-design will help the country in reducing the energy burden. These innovations may include improved architectural designs, energy-efficient building materials, electrical appliances and implementation of building energy-efficiency codes. In 1987, the National Energy Conservation Centre (ENERCON), was established under Ministry of Environment, Government of Pakistan, with the aim to build awareness among the masses for energy conservation, and to make policies regarding energy-conservation structures in the country. But no policy regarding building energy codes has been introduced by ENERCON till now. In collaboration with Pakistan Engineering Council (PEC), ENERCON has recently finalized the Building Energy Code of Pakistan Energy Provisions 2011 for which statutory notification is under process for necessary amendment in the building by-laws. The implementation of this Energy Code will result in 25 to 30 % of energy savings in the

  5. National Green Building Standard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-07-01

    DOE's Building America Program is a research and development program to improve the energy performance of new and existing homes. The ultimate goal of the Building America Program is to achieve examples of cost-effective, energy efficient solutions for all U.S. climate zones. Periodic maintenance of an ANSI standard by review of the entire document and action to revise or reaffirm it on a schedule not to exceed five years is required by ANSI. In compliance, a consensus group has once again been formed and the National Green Building Standard is currently being reviewed to comply with the periodic maintenance requirement of an ANSI standard.

  6. Building and Testing with Gradle

    CERN Document Server

    Berglund, Tim

    2011-01-01

    Build and test software written in Java and many other languages with Gradle, the open source project automation tool that's getting a lot of attention. This concise introduction provides numerous code examples to help you explore Gradle, both as a build tool and as a complete solution for automating the compilation, test, and release process of simple and enterprise-level applications. Discover how Gradle improves on the best ideas of Ant, Maven, and other build tools, with standards for developers who want them and lots of flexibility for those who prefer less structure. Use Gradle with Gr

  7. Competence building capacity shortage

    International Nuclear Information System (INIS)

    The objective of the project 'Competence Building Capacity Shortage' has been 'to increase knowledge about central approaches aimed at solving the peaking capacity problem in restructured power systems'. With respect to reserve markets, a model was developed in the project to analyze the relations between reserve requirements and prices in the spot and reserve markets respectively. A mathematical model was also developed and implemented, which also includes the balance market, and has a good ability to predict the relations between these markets under various assumptions. With some further development, this model can be used fore realistic analyses of these markets in a Nordic context. It was also concluded that certain system requirements with respect to frequency and time deviation can be relaxed without adverse effects. However, the requirements to system bias, Frequency Activated Operating Reserves and Frequency Activated Contingency Reserves cannot be relaxed, the latter because they must cover the dimensioning fault in the system. On the other hand, Fast Contingency Reserves can be reduced by removing requirements to national balances. Costs can furthermore be reduced by increasingly adapting a Nordic as opposed to national approach. A model for stepwise power flow was developed in the project, which is especially useful to analyze slow power system dynamics. This is relevant when analysing the effects of reserve requirements. A model for the analysis of the capacity balance in Norway and Sweden was also developed. This model is useful for looking at the future balance under various assumptions regarding e.g. weather conditions, demand growth and the development of the generation system. With respect to the present situation, if there is some price flexibility on the demand side and system operators are able to use reserves from the demand side, the probability for load shedding during the peak load hour is close to zero under the weather conditions after

  8. Competence building capacity shortage

    Energy Technology Data Exchange (ETDEWEB)

    Doorman, Gerard; Wangensteen, Ivar; Bakken, Bjoern

    2005-02-01

    The objective of the project 'Competence Building Capacity Shortage' has been 'to increase knowledge about central approaches aimed at solving the peaking capacity problem in restructured power systems'. With respect to reserve markets, a model was developed in the project to analyze the relations between reserve requirements and prices in the spot and reserve markets respectively. A mathematical model was also developed and implemented, which also includes the balance market, and has a good ability to predict the relations between these markets under various assumptions. With some further development, this model can be used fore realistic analyses of these markets in a Nordic context. It was also concluded that certain system requirements with respect to frequency and time deviation can be relaxed without adverse effects. However, the requirements to system bias, Frequency Activated Operating Reserves and Frequency Activated Contingency Reserves cannot be relaxed, the latter because they must cover the dimensioning fault in the system. On the other hand, Fast Contingency Reserves can be reduced by removing requirements to national balances. Costs can furthermore be reduced by increasingly adapting a Nordic as opposed to national approach. A model for stepwise power flow was developed in the project, which is especially useful to analyze slow power system dynamics. This is relevant when analysing the effects of reserve requirements. A model for the analysis of the capacity balance in Norway and Sweden was also developed. This model is useful for looking at the future balance under various assumptions regarding e.g. weather conditions, demand growth and the development of the generation system. With respect to the present situation, if there is some price flexibility on the demand side and system operators are able to use reserves from the demand side, the probability for load shedding during the peak load hour is close to zero under the weather

  9. 77 FR 66616 - Office of Federal High-Performance Green Buildings; Green Building Advisory Committee...

    Science.gov (United States)

    2012-11-06

    ... provides the schedule and agenda for the November 27, 2012, meeting of the Green Building Advisory...: Introductions & plans for today's meeting. Green Building Certification System Review update. Facilities... ADMINISTRATION Office of Federal High-Performance Green Buildings; Green Building Advisory...

  10. Consulting on Academic Library Buildings.

    Science.gov (United States)

    Mason, Ellsworth

    1980-01-01

    Addresses the following aspects of consulting on library buildings: new trends, the need for a consultant, selecting a consultant, timeliness in hiring, expectations, following through, and the cost of consulting. (FM)

  11. 324 Building Baseline Radiological Characterization

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Reeder, J.C. Cooper

    2010-06-24

    This report documents the analysis of radiological data collected as part of the characterization study performed in 1998. The study was performed to create a baseline of the radiological conditions in the 324 Building.

  12. Building Blueprints: Improvement through Simplification.

    Science.gov (United States)

    College Planning & Management, 2001

    2001-01-01

    Examines the modernization of Areeda Hall faculty offices at Harvard Law School (Massachusetts) that brought a new architectural presence to the campus while eliminating the building of a circulation maze. Before and after photos are included. (GR)

  13. Dampness in Buildings and Health

    DEFF Research Database (Denmark)

    Clausen, Geo; Rode, Carsten; Bornehag, Carl-Gustaf;

    1999-01-01

    on air distribution in indoor spaces. Particularly, using CFD models, it should be possible to study the local conditions in the vicinity of the human body.· Modelling and experimental investigation of humidity transfer and energy consumption in buildings. The research aims at establishing complete...... of the factors that influence the well being of occupants in the indoor climate. The perspective of this knowledge should be widened such that it will be possible to carry out an integral optimisation of a high indoor air quality in durable, low energy consuming buildings.While located at DTU, the centre...... modelling capabilities of the hygrothermal conditions in buildings with their spaces, building materials, furnishing, activity of occupants, and influence from exterior conditions....

  14. Understanding Net Zero Energy Buildings

    DEFF Research Database (Denmark)

    Salom, Jaume; Widén, Joakim; Candanedo, José;

    2011-01-01

    Although several alternative definitions exist, a Net-Zero Energy Building (Net ZEB) can be succinctly described as a grid-connected building that generates as much energy as it uses over a year. The “net-zero” balance is attained by applying energy conservation and efficiency measures...... and by incorporating renewable energy systems. While based on annual balances, a complete description of a Net ZEB requires examining the system at smaller time-scales. This assessment should address: (a) the relationship between power generation and building loads and (b) the resulting interaction with the power grid....... This paper presents and categorizes quantitative indicators suitable to describe both aspects of the building’s performance. These indicators, named LMGI - Load Matching and Grid Interaction indicators, are easily quantifiable and could complement the output variables of existing building simulation tools...

  15. THE CONTENTS OF BUILDING LEASEHOLD

    Directory of Open Access Journals (Sweden)

    Kamyshanskiy V. P.

    2015-11-01

    Full Text Available The article is devoted to one of the most disputable categories of jurisprudence – to the contents of Building leasehold. In the article there has been presented the research of the legal nature of the institution of building leasehold (superficies. There have been traced the particulars of formation of the Roman legal (classical model of building leasehold and the interpretation of this institution in foreign civil legislation. It has been noted that certain countries apply the classical Roman model of building leasehold while others use the model of "the shared property" of the land plot and of the piece of the estate built on this plot. There was conducted the analysis of the German model inheritance law of building leasehold on the basis of which there was made the conclusion about its independent nature and uniqueness. The historical and the comparative legal methods of the research have enabled to identify the essential differences of the employed models of building leasehold and the specific features of their application in the countries of roman-germanic law and in the Commonwealth of Independent States. There have been studied the approaches of the domestic civilized doctrine in terms of building leasehold and the specific features of its implementation in the draft version of the Civil Code of the Russian Federation. There has been affirmed that the draft version of the Civil Code of the Russian Federation admits the existence of the two models of the building leasehold: the design one and the classical one. There has been applied critical approach to the analysis of the design model of building leasehold in comparison with its Roman and Germanic legal constructions; there have been presented recommendations for its improvement. It is proposed to abandon the temporary ownership of the premises in the building constructed based on the Treaty on the law of the land. We proposed to replace it with a specific property right – "right of

  16. A Novel Tetrathiafulvalene Building Block

    DEFF Research Database (Denmark)

    Jeppesen, Jan Oskar; Takimiya, Kazuo; Thorup, Niels;

    1999-01-01

    Efficient synthesis of a novel tetrathiafulvalene building block. 2,3-bis(2-cyanoethylthio)-6,7-bis(thiocyanato-methyl)tetrathiafulv alene (7) useful for stepwise and asymmetrical bis-function-alization is reported.......Efficient synthesis of a novel tetrathiafulvalene building block. 2,3-bis(2-cyanoethylthio)-6,7-bis(thiocyanato-methyl)tetrathiafulv alene (7) useful for stepwise and asymmetrical bis-function-alization is reported....

  17. Building America House Simulation Protocols

    Energy Technology Data Exchange (ETDEWEB)

    Hendron, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Engebrecht, Cheryn [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-09-01

    The House Simulation Protocol document was developed to track and manage progress toward Building America's multi-year, average whole-building energy reduction research goals for new construction and existing homes, using a consistent analytical reference point. This report summarizes the guidelines for developing and reporting these analytical results in a consistent and meaningful manner for all home energy uses using standard operating conditions.

  18. A Guide to Building Commissioning

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, Michael C.

    2011-09-01

    Commissioning is the process of verifying that a building's heating, ventilation, and air conditioning (HVAC) and lighting systems perform correctly and efficiently. Without commissioning, system and equipment problems can result in higher than necessary utility bills and unexpected and costly equipment repairs. This report reviews the benefits of commissioning, why it is a requirement for Leadership in Energy and Environmental Design (LEED) certification, and why building codes are gradually adopting commissioning activities into code.

  19. Build Autonomic Agents with ABLE

    Institute of Scientific and Technical Information of China (English)

    吴吉义

    2007-01-01

    The IBM Agent Building and Learning Environment(ABLE) provides a lightweight Java~(TM) agent frame- work,a comprehensive JavaBeansTM library of intelligent software components,a set of development and test tools, and an agent platform.After the introduction to ABLE,classes and interfaces in the ABLE agent framework were put forward.At last an autonomic agent that is an ABLE-based architecture for incrementally building autonomic systems was discussed.

  20. Building a Chinatown From Scratch

    Institute of Scientific and Technical Information of China (English)

    Li Zhijian

    2011-01-01

    ON Ahmadou Ahidjo Street in Douala, the economic capital of Cameroon,there are several buildings bearing Chinese names like Da Shanghai (Great Shanghai) and Zhong Ka Youyilou (Sino-Cameroon Friendship Building).This is Cameroon's Chinatown.Here,passersby flock to the Great China Hotel and the Great China Market.Located at the edge of the neighborhood,both are owned by one man:Hu Xiaomeng.

  1. Renovation work at Building 280

    CERN Multimedia

    EN Department

    2010-01-01

    Processing units and containers will be temporarily installed in front of Building 280 between 17 and 21 February 2010 while renovation work is carried out on electrical equipment. During this period, the Route FERMI, i.e. the area between Buildings 280 and 530, will be closed to traffic. You are requested to comply with the road signs in place. Thank you for your understanding. For further information, please call 160481. EN-EL Group

  2. Daylight utilisation in office buildings

    DEFF Research Database (Denmark)

    Christoffersen, Jens

    This Ph.D. thesis presents the qualitative and quantitative consequences of full-scale measurements on two daylighting systems, light shelf and Venetian blinds. The systems were investigated to assess their ability to increase daylight penetration and improve daylight distribution in the interior...... the benefits and difficulties regarding use of daylight in office buildings, but it is hoped that the report will provide daylight conscious building design in forthcoming non-domestic buil dings....

  3. Dust and the Sick Building Syndrome

    DEFF Research Database (Denmark)

    Gyntelberg, Finn; Suadicani, Poul; Wohlfahrt Nielsen, Jan;

    1994-01-01

    Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome......Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome...

  4. Wynkoop Building Performance Measurement: Water

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, Kimberly M.; Kora, Angela R.

    2012-08-26

    This report is a summary of the water analysis performance for the Denver, Colorado Wynkoop Building. The Wynkoop Building (Figure 1) was built in 2006 as the Environmental Protection Agency (EPA) Region 8 Headquarters intended to house over 900 occupants in the 301,292 gross square feet (248,849 rentable square feet). The building was built on a brownfield in the Lower Downtown Historic District as part of an urban redevelopment effort. The building was designed and constructed through a public-private partnership with the sustainable design elements developed jointly by General Services Administration (GSA) and EPA. That partnership is still active with all parties still engaged to optimize building operations and use the building as a Learning Laboratory. The building design achieved U.S. Green Building Council Leadership in Energy and Environmental Design for New Construction (LEED-NC) Gold Certification in 2008 (Figure 2) and a 2008 EPA Energy Star Rating of 96 with design highlights that include: (1) Water use was designed to use 40% less than a typical design baseline. The design included low flow fixtures, waterless urinals and dual flush toilets; (2) Native and adaptive vegetation were selected to minimize the need for irrigation water for landscaping; and (3) Energy use intensity was modeled at 66.1 kBtus/gross square foot, which is 39% better than ASHRAE 90.1 1999. The Wynkoop Building water use (10 gallons/square foot) was measured at lower than industry average (15 gallons/square foot) and GSA goals (13 gallons/square foot), however, it was higher than building management expected it would be. The type of occupants and number of occupants can have a significant impact on fixture water use. The occupancy per floor varied significantly over the study time period, which added uncertainty to the data analysis. Investigation of the fixture use on the 2nd, 5th, and 7th floors identified potential for water use reduction if the flush direction of the dual

  5. Building envelope innovation: smart facades for non residential buildings

    Directory of Open Access Journals (Sweden)

    Marco Sala

    2011-11-01

    Full Text Available The research analyzes the evolution of smart façade systems in the area of design and industrial production, in order to investigate the technological, functional and qualitative standards of dynamic façade and evaluate the energy performance of the building envelope as a dynamic system that interacts between indoor and outdoor environment. The study focused on dynamic envelopes for office building analyzing the evolution of façade systems in terms of: building construction, innovative systems, smart materials, dynamic system. Aiming to improve building energy performances. The research, developed during the PhD thesis “Smart Envelope - dynamic and innovative technologies for energy saving” and the research “Abitare Mediterraneo”, aims to identify and define the energy performances of smart envelopes trough the analysis of the state of art, related to dynamic building envelope of double skin façade, and the development of a new dynamic façade system.

  6. Buildings and Health. Educational campaign for healthy buildings. Educational material

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    In recent years health and comfort problems associated with the indoor climate have come to constitute a problem in Sweden. To come to grips with this a nationwide educational campaign on Buildings and Health is being run. It is directed to those involved in planning, project design, construction and management of buildings. The objective is to convey a body of knowledge to the many occupational and professional groups in the construction sector on how to avoid indoor climate problems in homes, schools, offices and other workplaces. The campaign is being run by the Swedish National Board of Housing and Planning and the Swedish Council for Building Research, in co-operation with various organizations and companies in the construction industry, and with municipalities and authorities. The knowledge which is being disseminated through the campaign is summarized in this compendium. figs., tabs.

  7. Building products for sustainable buildings; Bauprodukte fuer nachhaltige Gebaeude

    Energy Technology Data Exchange (ETDEWEB)

    Blumberg, Martin; Urbanek, Anja [brands und values GmbH, Bremen (Germany)

    2013-04-15

    In the light of the energy efficiency, sustainability and the increasing distribution of buildings certifications environmental product declarations have grown in significance. The environmental product declaration program for building products was organized by the Institute Construction and Environment e.V. (Koenigswinter, Federal Republic of Germany). Beside the definition of the product group specific requirements and certifications as well as an independent review process of the completed environmental product declarations, the Advisory Council guarantees that the program rules of the Institute Construction and Environment e.V. continue to develop in conformity to international standards.

  8. Do chimpanzees build comfortable nests?

    Science.gov (United States)

    Stewart, Fiona A; Pruetz, Jill D; Hansell, Mike H

    2007-08-01

    Nests built by wild chimpanzees (Pan troglodytes verus) were studied at the Fongoli research site in southeastern Senegal from January 2004-May 2004 to investigate the role of comfort in nest building behavior by relating measures of nest comfort and building effort. Nest comfort across zones of the nest surface were compared with construction effort for 25 nests. Several variables of nest comfort were assessed: (1) physical discomfort, (2) visible discomfort, and (3) softness. Physical discomfort was used as a representative measure of nest discomfort. Building effort was measured by (1) construction force, (2) complexity, and (3) added material. Spearman rank correlations compared Effort and Comfort measures for both whole nests and central versus edge zones. The results show that construction force and complexity do not influence comfort of the nest as a whole. Greater Construction force correlates with more nest edge discomfort, yet the central area shows no difference. More complex nests do result in a more comfortable central area in the nest. Nests built with greater force may result in more discomfort, whereas complexity may allow chimpanzees to maintain comfort in a central area for sleep. Chimpanzees may place additional leaves or twigs over hard branches, protruding from the nest surface after construction, to increase comfort of the central nest area. Functions of chimpanzee nest building are likely to be several, but these results suggest comfort is a factor in nest building behavior. PMID:17358021

  9. Smoke control in buildings: An overview

    NARCIS (Netherlands)

    Twilt, L.; Oerle, N.J. van; Leur, P.H.E. van de

    1996-01-01

    Smoke poses a major hazard to people in a building involved in fire, being directly responsible for the majority of all deaths in building fires. Whereas the fire itself generally spreads through the building at a relatively slow rate, smoke takes only minutes to fill the building, if no actions are

  10. Fault detection and diagnosis for smart buildings

    DEFF Research Database (Denmark)

    Lazarova-Molnar, Sanja; Shaker, Hamid Reza; Mohamed, Nader;

    2016-01-01

    Worldwide, buildings account for ca. 40% of the total energy consumption and ca. 20% of the total CO2 emissions. While most of the energy goes into primary building use, a significant amount of energy is wasted due to malfunctioning building system equipment and wrongly configured Building Manage...

  11. Ecological modernization of sustainable buildings

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole; Gram-Hanssen, Kirsten

    2008-01-01

    This article will examine how the contemporary development of sustainable buildings has been influenced by the concept of ecological modernisation. Ecological modernisation is a policy concept describing how environmental considerations are increasingly being integrated into modern society......'s institutions through e.g. new types of co-operation and new applications of economic and market dynamics. The article is based on recent examples from politics and practice in the construction sector in Denmark, where sustainable buildings have gone through great changes - from being primarily isolated cases...... of governance, standardisation and visibility, the conclusion is that in many ways ecological modernisation has penetrated in Danish sustainable buildings and has contributed to a positive development. However, there are aspects of sustainable consumption that this development does not relate to, including...

  12. ATLAS Nightly Build System Upgrade

    CERN Document Server

    Dimitrov, G; The ATLAS collaboration; Simmons, B; Undrus, A

    2014-01-01

    The ATLAS Nightly Build System is a facility for automatic production of software releases. Being the major component of ATLAS software infrastructure, it supports more than 50 multi-platform branches of nightly releases and provides ample opportunities for testing new packages, for verifying patches to existing software, and for migrating to new platforms and compilers. The Nightly System testing framework runs several hundred integration tests of different granularity and purpose. The nightly releases are distributed and validated, and some are transformed into stable releases used for data processing worldwide. The first LHC long shutdown (2013-2015) activities will elicit increased load on the Nightly System as additional releases and builds are needed to exploit new programming techniques, languages, and profiling tools. This paper describes the plan of the ATLAS Nightly Build System Long Shutdown upgrade. It brings modern database and web technologies into the Nightly System, improves monitoring of nigh...

  13. ATLAS Nightly Build System Upgrade

    CERN Document Server

    Dimitrov, G; The ATLAS collaboration; Simmons, B; Undrus, A

    2013-01-01

    The ATLAS Nightly Build System is a facility for automatic production of software releases. Being the major component of ATLAS software infrastructure, it supports more than 50 multi-platform branches of nightly releases and provides ample opportunities for testing new packages, for verifying patches to existing software, and for migrating to new platforms and compilers. The Nightly System testing framework runs several hundred integration tests of different granularity and purpose. The nightly releases are distributed and validated, and some are transformed into stable releases used for data processing worldwide. The first LHC long shutdown (2013-2015) activities will elicit increased load on the Nightly System as additional releases and builds are needed to exploit new programming techniques, languages, and profiling tools. This paper describes the plan of the ATLAS Nightly Build System Long Shutdown upgrade. It brings modern database and web technologies into the Nightly System, improves monitoring of nigh...

  14. Building in a Market Economy

    DEFF Research Database (Denmark)

    Bonke, Sten; Levring, Peter

    This book offers a "state of the art" introduction to the "Danish way" of building. It presents a source of information and inspiration to the complex transitional process of rearranging the construction sectors in Central and Eastern European countries. The text gives a historical presentation...... of the development in the built environment since the second world war. Subsequently the different current regulative systems on state and on building industry level are revised. The more practical managerial methods are then elaborated and associated with the common organisational frameworks, indicating the roles...... and functions of the main actors in the building process. During these passages and in a final section important future developments are highlighted, and characteristic research and development projects are presented....

  15. Climate Responsive Buildings Concepts in Hong Kong

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; van der Aa, A.;

    2006-01-01

    of responsive building elements, of integrated building concepts and of environmental performance assessment methods to improve and optimize responsive building elements to develop and optimize new building concepts with integration of responsive building elements, HVAC-systems as well as natural and renewable......) and discusses its usefulness for Hong Kong. Special focus was put on the description of the state of the art of the application of responsive building elements and of integrated building concepts in Hong Kong. A number of interviews of key players in the construction industry in Hong Kong revealed that not many...

  16. Energy savings in Danish residential building stock

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Svendsen, Svend

    2006-01-01

    A large potential for energy savings exists in the Danish residential building stock due to the fact that 75% of the buildings were constructed before 1979 when the first important demands for energy performance of building were introduced. It is also a fact that many buildings in Denmark face...... buildings representing the residential building stock and based on these calculations an assessment of the energy-saving potential is performed. A profitable savings potential of energy used for space heating of about 80% is identified over 45 years (until 2050) within the residential building stock...

  17. Photovoltaics for Buildings Cutting-Edge PV

    International Nuclear Information System (INIS)

    Photovoltaic (PV) technology development for building-integrated applications (commonly called PV for Buildings) is one of the fastest growing areas in the PV industry. Buildings represent a huge potential market for photovoltaics because they consume approximately two-thirds of the electricity consumed in the US. The PV and buildings industries are beginning to work together to address issues including building codes and standards, integration, after-market servicing, education, and building energy efficiency. One of the most notable programs to encourage development of new PV-for-buildings products is the PV:BONUS program, supported by the US Department of Energy. Demand for these products from building designers has escalated since the program was initiated in 1993. This paper presents a range of PV-for-buildings issues and products that are currently influencing today's PV and buildings markets

  18. The energy performance of office buildings throughout their building process

    NARCIS (Netherlands)

    Entrop, A.G.; Dewulf, G.P.M.R.; Wamelink, J.W.F.; Geraedts, R.P.; Volker, L.

    2011-01-01

    Many innovative techniques and policy measures have been introduced to reduce energy consumption. Despite the high ambitions and societal pressures, the adoption rate of energy measures in office buildings is still low. Using adoption theories this paper provides a framework to analyse the adoption

  19. Building America Expert Meeting Report. Hydronic Heating in Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, Jordan [Levy Partnership, Inc., New York, NY (United States)

    2011-10-01

    This expert meeting was presented by the ARIES Collaborative, and discussed cost-effective controls and distribution retrofit options for hot water and steam space heating systems in multi-family buildings with the goals of reducing energy waste and improving occupant comfort.

  20. Flash Builder building user interaction

    CERN Document Server

    Rocchi, Cesare

    2010-01-01

    Develop a working understanding of events and components, and containers and states so you can build and deploy RIAs in Flex. Work through a demo implementation of a login panel that employs feedback from the server side, to hone your understanding. Use the validators and the debugger to inspect your code execution. Building User Interaction is the second of five articles that will be compiled in the book, Data Visualization with Flash Builder: Designing RIA and AIR Applications with Remote Data Sources. Each full-color article illustrates specific aspects of Flash Builder data visualization

  1. Moisture dynamics in building envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Peuhkuri, R.

    2003-07-01

    The overall scope of this Thesis 'Moisture dynamics in building envelopes' has been to characterise how the various porous insulation materials investigated performed hygro thermally under conditions similar to those in a typical building envelope. As a result of the changing temperature and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. (au)

  2. Dampness in buildings and health

    DEFF Research Database (Denmark)

    Bornehag, Carl-Gustaf; Blomquist, G.; Gyntelberg, F.;

    2001-01-01

    in the epidemiological literature. A literature search identified 590 peer-reviewed articles of which 61 have been the foundation for this review. The review shows that "dampness" in buildings appears to increase the risk for health effects in the airways, such as cough, wheeze and asthma. Relative risks......Several epidemiological investigations concerning indoor environments have indicated that "dampness" in buildings is associated to health effects such as respiratory symptoms, asthma and allergy The aim of the present interdisciplinary review is to evaluate this association as shown...

  3. Sustainable Building in South China

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-11-15

    In view of sustainable building prioritized as a strategic sector by local government in South China, and the strong Dutch expertise and wide market recognition in this field especially the substantive presence of the Shanghai-based Dutch Sustainable Building Platform, the market in the South could be very potential and interesting to Dutch companies though strong competitors as well. An overview is given of the developments in the Chinese province Guangdong, Shenzhen city, Guangzhou City, Fujian Province, Guangxi Zhuang Autonomous Region, Hainan Province. Also information is given about important potential counterparts: China Merchant Group, Guangdong Energy Conservation Association, and potential areas for cooperation.

  4. Resilient mounting systems in buildings

    NARCIS (Netherlands)

    Breeuwer, R.; Tukker, J.C.

    1976-01-01

    The basic elements of resilient mounting systems are described and various measures for quantifying the effect of such systems defined. Using electrical analogue circuits, the calculation of these measures is illustrated. With special reference to resilient mounting systems in buildings, under speci

  5. Daylight as a building material

    DEFF Research Database (Denmark)

    Thule Kristensen, Peter; Madsen, Merete

    2005-01-01

    The article draws on examples to chronologically trace the use of daylight as building material in architecture of the 20th and early 21st century. The essay covers works of Mies van der Rohe, Le Corbusier, Erik Bryggman, Rudolf Schwarz, Alvar Aalto, Aldo Rossi, Jørn Utzon, Daniel Libeskind, Peter...

  6. Building with Earthquakes in Mind

    Science.gov (United States)

    Mangieri, Nicholas

    2016-04-01

    Earthquakes are some of the most elusive and destructive disasters humans interact with on this planet. Engineering structures to withstand earthquake shaking is critical to ensure minimal loss of life and property. However, the majority of buildings today in non-traditional earthquake prone areas are not built to withstand this devastating force. Understanding basic earthquake engineering principles and the effect of limited resources helps students grasp the challenge that lies ahead. The solution can be found in retrofitting existing buildings with proper reinforcements and designs to deal with this deadly disaster. The students were challenged in this project to construct a basic structure, using limited resources, that could withstand a simulated tremor through the use of an earthquake shake table. Groups of students had to work together to creatively manage their resources and ideas to design the most feasible and realistic type of building. This activity provided a wealth of opportunities for the students to learn more about a type of disaster they do not experience in this part of the country. Due to the fact that most buildings in New York City were not designed to withstand earthquake shaking, the students were able to gain an appreciation for how difficult it would be to prepare every structure in the city for this type of event.

  7. Building a Copper Pipe "Xylophone."

    Science.gov (United States)

    Lapp, David R.

    2003-01-01

    Explains how to use the equation for frequency of vibration of a transversely oscillating bar or pipe with both ends free to vibrate to build a simple and inexpensive xylophone from a 3-meter section of copper pipe. The instrument produces a full major scale and can be used to investigate various musical intervals. (Author/NB)

  8. Building contacts for the SKA

    Science.gov (United States)

    Bowler, Sue

    2016-06-01

    The Square Kilometre Array needs industrial expertise; SKA technology will, in turn, streamline big-data challenges for business and society. Or that's the idea: Sue Bowler reports on a day of networking designed to build industry-academia collaborations in the UK.

  9. Building Your Undergraduate Physics Career

    Science.gov (United States)

    2014-03-01

    In this interactive event for undergraduates, students will learn important lessons about career preparation, including skill building, networking, and developing ``soft skills.'' Our expert panel of working physicists will be on hand to answer questions, offer advice, and share their stories. Light refreshments will be served.

  10. Building TQM into nursing management.

    Science.gov (United States)

    Masters, M L; Masters, R J

    1993-01-01

    Total quality management (TQM) is a management philosophy that addresses problems currently faced by health care, specifically reducing costs while improving quality of services. As hospital administrators embrace this new management style, nurse executives and managers will be challenged to implement TQM. Building TQM into nursing management will improve quality and reduce costs while meeting the needs of health care customers.

  11. Building server capabilities in China

    DEFF Research Database (Denmark)

    Adeyemi, Oluseyi; Slepniov, Dmitrij; Wæhrens, Brian Vejrum;

    2012-01-01

    The purpose of this paper is to further our understanding of multinational companies building server capabilities in China. The paper is based on the cases of two western companies with operations in China. The findings highlight a number of common patterns in the 1) managerial challenges related...

  12. Urban heritage, building maintenance: foundations

    NARCIS (Netherlands)

    Verhoef, L.G.W.

    1999-01-01

    What do we understand by the term 'foundations'? This general idea may embody the literal ' groundwork' that provides support for a building and may possibly include the entire structural works that serve to pre vent subsidence. Remarkably, in this definition the word 'groundwork' incorporates both

  13. Green buildings: Implications for acousticians

    Science.gov (United States)

    Noble, Michael R.

    2005-04-01

    This presentation will deal with the practical implications of green design protocols of the US Green Building Council on interior acoustics of buildings. Three areas of particular consequence to acousticians will be discussed. Ventilation Systems: reduced energy consumption goals dictate reliance on natural cooling and ventilation using ambient air when possible. The consequent large openings in the building envelope to bring fresh air into rooms, and similar sized openings to transfer the mixed air out, can severely compromise the noise isolation of the rooms concerned. Radiant Cooling: the heavy concrete floors of buildings can be used as a thermal flywheel to lessen the cooling load, which forces the concrete ceilings to be exposed to the occupied rooms for heat transfer, and strictly limits the application of acoustical absorption on the ceilings. This challenges the room acoustics design. Green Materials: the LEED protocols require the elimination of potentially harmful finishes, including fibrous materials which may impact air quality or contribute to health problems. Since the backbone of sound absorption is glass and mineral fibres, this further challenges provision of superior room acoustics. Examples and commentary will be provided based on current and recent projects.

  14. Building a Culinary Arts Academy

    Science.gov (United States)

    Brown, Robert L.

    2005-01-01

    When Judy Karen Brown (the 2004 Alabama Family and Consumer Sciences Teacher of the Year) arrived at Bob Jones High School (BJHS) in Madison, Alabama, in the summer of 1999, she immediately identified a need to build both student and community interests in family and consumer sciences (FACS). She noticed the student and faculty interest in the…

  15. Capacity Building in Local Government

    Directory of Open Access Journals (Sweden)

    Rochyati Wahyuni Triana

    2013-02-01

    Full Text Available The aim of this research is to examine the concept of local government capacity building in both theoretical and operational aspects, regarding especially with local authorities in Indonesia, after the enforcement of regional autonomy. This is a basic research (fundamental research of library research type. Data collection technique involves using data sourced from a variety of secondary sources, as it should be; books, journals, and related legislation. To draw a conclusion regarding with the building of regional capacity after the implementation of regional autonomy, the data are analyzed using descriptive analysis technique; that is, examining secondary data based on Indonesian condition. This research concludes that Capacity Building is a huge job for the an autonomous local government, particularly when dealing with the system which is deemed to prioritize self-serving rather than public serving; yet this capacity building mission deserves to fight for. Stakeholders (other than legislatives need to regularly monitor the improved performance of the government so that the high expectation of the society could be fulfilled through the enforcement of regional autonomy.

  16. Energy Management in Municipal Buildings.

    Science.gov (United States)

    Massachusetts State Dept. of Community Affairs, Boston. Energy Conservation Project.

    This manual is written for the manager or supervisor responsible for instituting an energy management program for municipal buildings. An introduction discusses the management issues facing municipal government in dealing with the need to reduce energy consumption. The guide reviews methods for central coordination of activity to ensure that…

  17. Build Your Own Particle Sensor

    Science.gov (United States)

    This is an information packet explaining an educational outreach activity, where the participant does some simple electronics with low cost components to build a particle sensor that can turn one to three small lights on based upon the detected concentration of particles.

  18. Building block filtering and mixing

    NARCIS (Netherlands)

    Kemenade, C.H.M. van

    1998-01-01

    A three-stage evolutionary method, the BBF-GA is introduced. BBF-GA is an acronym for building block filtering genetic algorithm. During the first stage, an ensemble of fast evolutionary algorithms is used to explore the search space. The best individual found by each of these evolutionary algorithm

  19. The House That Affirmation Builds

    Science.gov (United States)

    Kessler, Susan Stone; Snodgrass, April M.

    2014-01-01

    The authors, principals at a high-poverty school in Nashville, Tennessee, find that key actions to building a strong school culture and morale are communicating clearly, recognizing everyone's contributions, and giving students and parents many ways to become involved at school. They portray a specific process that Hunters Lane High School…

  20. Structural rehabilitation of old buildings

    CERN Document Server

    Guedes, João; Varum, Humberto

    2014-01-01

    The present book describes the different construction systems and structural materials and solutions within the main old buildings typologies, and it analyses the particularities of each of them, including mechanical properties, structural behaviour, typical damage patterns and collapse mechanisms. Common or pioneering intervention measures to repair and/or strengthen some of these structural elements are also reviewed.

  1. The COSPAR Capacity Building Initiative

    NARCIS (Netherlands)

    Gabriel, C.; Willmore, P.; Méndez, M.; Mathieu, P.-P.; Santolik, O.; Smith, R.; Evans, Ian N.; Accomazzi, Alberto; Mink, Douglas J.; Rots, Arnold H.

    2011-01-01

    The COSPAR Capacity Building Workshops have been conceived to meet the following objectives: (1) To increase knowledge and use of public archives of space data in order both to broaden the scope of research programs in developing countries and to ensure that scientists in those countries are aware o

  2. Collapse simulation of building constructions

    Directory of Open Access Journals (Sweden)

    Nekrest'yanov Viktor Nikolaevich

    Full Text Available The physical reasons for building structures destruction are both the forces arising at stress-strain state of construction elements and external influences arising at emergency situations, as well as their moments, impulses and periodic impulses with the frequencies close to of fluctuations frequencies of construction elements. We shall call the mathematical calculation models for the parameters-reasons of destructions the basic models. The basic models of destruction of building structures elements allow not only providing necessary level of reliability and survivability of the elements and the construction as a whole already at the stage of their design, but also giving the chance, at their corresponding completion, to provide rational decisions on the general need of recovery works and their volume depending on destruction level. Especially important for rational design decisions development, which ensure the demanded constructional safety of building structures, is library creation of the basic mathematical models of standard processes of bearing elements destructions for standard construction designs for the purpose of the further forecast (assessment of the level and probabilities of standard destructions. Some basic mathematical models of destructions processes of the standard elements of building structures are presented in the present article. A model of accounting for construction defects and a model of obtaining requirements to probabilities of partial destructions of a construction are given. Both of these models are probabilistic.

  3. School Buildings in Today's Crisis

    Science.gov (United States)

    Blyth, Alastair

    2009-01-01

    To get a picture of the impact of the current economic and financial crisis on educational building programmes so far, the OECD Centre for Effective Learning Environments (CELE) has been conducting a survey of member countries and regions. The survey focuses on three main issues: the impact of the crisis on publicly funded projects, the impact on…

  4. Software Build and Delivery Systems

    Energy Technology Data Exchange (ETDEWEB)

    Robey, Robert W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-10

    This presentation deals with the hierarchy of software build and delivery systems. One of the goals is to maximize the success rate of new users and developers when first trying your software. First impressions are important. Early successes are important. This also reduces critical documentation costs. This is a presentation focused on computer science and goes into detail about code documentation.

  5. User Participation in the Building Process

    DEFF Research Database (Denmark)

    Christiansson, Per; Svidt, Kjeld; Sørensen, Kristian Birch;

    2011-01-01

    Virtual Innovation in Construction (VIC) is a project aiming to develop an Information and Communication Technology (ICT) supported methodology VIC-MET, to involve building end-users in a creative innovation process together with building designers, and to capture and formulate end-user needs...... be established and conceptual building designs be illustrated. This is done in (2) 'Conceptual modelling space'. Here the VIC-MET proposes different tools and processes to build up a common understanding of end-user needs and values. In (3) 'Functional consolidation space', needs are linked to functional...... building systems (FBS), which are realized as component building systems (CBS), which will form parts in the total building solution. The formulated needs provide input to specific requirements in order to assure expected performance of the building components. The final virtual building model or part...

  6. Comparison of Building Energy Modeling Programs: Building Loads

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Dandan [Tsinghua Univ., Beijing (China); Hong, Tianzhen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yan, Da [Tsinghua Univ., Beijing (China); Wang, Chuang [Tsinghua Univ., Beijing (China)

    2012-06-01

    This technical report presented the methodologies, processes, and results of comparing three Building Energy Modeling Programs (BEMPs) for load calculations: EnergyPlus, DeST and DOE-2.1E. This joint effort, between Lawrence Berkeley National Laboratory, USA and Tsinghua University, China, was part of research projects under the US-China Clean Energy Research Center on Building Energy Efficiency (CERC-BEE). Energy Foundation, an industrial partner of CERC-BEE, was the co-sponsor of this study work. It is widely known that large discrepancies in simulation results can exist between different BEMPs. The result is a lack of confidence in building simulation amongst many users and stakeholders. In the fields of building energy code development and energy labeling programs where building simulation plays a key role, there are also confusing and misleading claims that some BEMPs are better than others. In order to address these problems, it is essential to identify and understand differences between widely-used BEMPs, and the impact of these differences on load simulation results, by detailed comparisons of these BEMPs from source code to results. The primary goal of this work was to research methods and processes that would allow a thorough scientific comparison of the BEMPs. The secondary goal was to provide a list of strengths and weaknesses for each BEMP, based on in-depth understandings of their modeling capabilities, mathematical algorithms, advantages and limitations. This is to guide the use of BEMPs in the design and retrofit of buildings, especially to support China’s building energy standard development and energy labeling program. The research findings could also serve as a good reference to improve the modeling capabilities and applications of the three BEMPs. The methodologies, processes, and analyses employed in the comparison work could also be used to compare other programs. The load calculation method of each program was analyzed and compared to

  7. Building Maintenance in Old Buildings Conservation Approach: An Overview of Related Problems

    Directory of Open Access Journals (Sweden)

    Brit Kayan

    2006-12-01

    Full Text Available Building maintenance in conservation of old buildings is one of the approaches applied within the built environment of Malaysia. For instance, it is realised that these old buildings contribute an important significance to our nation's priceless heritage and unique historical development. However, most of these buildings' maintenance is influenced by related problems that affect the overall building conservation approach. Therefore, these old buildings face problems which greatly affect their overall condition and performance: building structure; building appearance and aesthetic; building materials and building character. In most critical situations, there is a greater possibility that we could lose the cultural significance and heritage values of these old buildings through ignoring the related problems. This paper tries to identify the related problems, reveal the findings and discuss suitable approaches to conserving these old buildings.

  8. 77 FR 2296 - Office of Federal High-Performance Green Buildings; the Green Building Advisory Committee...

    Science.gov (United States)

    2012-01-17

    ... provides the schedule for three teleconference meetings of the Green Building Advisory Committee (the... ADMINISTRATION Office of Federal High-Performance Green Buildings; the Green Building Advisory Committee; Notification of Upcoming Public Advisory Teleconference Meetings AGENCY: Office of Governmentwide...

  9. Protein-coated magnetic beads for the measurement of drug-protein association constant%高磁场响应性蛋白偶联磁性微球的制备及其在药物-蛋白结合常数测定中的应用

    Institute of Scientific and Technical Information of China (English)

    潘晓霞

    2014-01-01

    A simple and fast method for the determination of the association constant( Ka )of drugs to ser-um albumin has been developed by using bovine serum albumin-coated magnetic beads( MB-BSA). Opti-mum type of MB which has least nonspecific adsorption effect was screened,the maximum amount of the two protein bond coupling method resulting magnetic microsphere are all 50 μg/mg. The crosslinking method was also optimized to get the appropriate bound capacity of BSA. Then the adsorption equilibrium time and drug-protein interaction mode using ibuprofen as the model drug was studied. Finally,the Ka for ibuprofen,tryptophan,ambrisentan,retigabine and roflumilast were calculated via Rosenthal equation by detecting the concentration of drugs before and after incubation with MB-BSA. Though above research,we improved and perfected the MB-BSA method to calculate the drug-protein association constant.%以蛋白偶联磁性微球( MB)为固相基质,通过磁场下快速分离蛋白和上清,高效液相色谱法测定上清中的药物浓度,建立了测定药物与蛋白结合常数( Ka )的新方法。选择对药物非特异性吸附较少和磁响应性较高的四氧化三铁磁性微球为载体,分别以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐/N-羟基琥珀酰亚胺( EDC/NHS)及戊二醛作为偶联剂,制备牛血清白蛋白( BSA)包覆的磁性微球( MB-BSA),两种偶联方法所得磁性微球的蛋白最大键合量均为50μg/mg。以布洛芬为模型药物,研究药物在蛋白偶联磁性微球上的吸附行为及药物-蛋白的相互作用模式,优化药物吸附和解吸过程。利用高效液相色谱法测定经磁性分离的上清液中的游离药物浓度,通过罗森塔尔方程计算药物与BSA结合常数。最后将所建立的方法应用到色氨酸、安立生坦、瑞替加滨、罗氟司特等4种不同药物与蛋白的结合常数的测定,获得满意结果。

  10. Team Building e a enfermagem Team Building e enfermería Team Building and nursing

    Directory of Open Access Journals (Sweden)

    Filipa Homem

    2012-07-01

    Full Text Available Num ambiente de insatisfação crescente e de imprevisibilidade como é o da enfermagem, cada vez mais é fundamental motivar as equipas, conferindo-lhes competências pessoais, relacionais, comunicacionais e, acima de tudo, fomentar o trabalho em equipa e consequentemente a produtividade. O Team Building, surge assim como uma estratégia eficaz para obter resultados positivos. Por ser uma estratégia ainda pouco utilizada em Portugal, decidimos realizar este artigo teórico sobre o assunto e refletir sobre a sua pertinência e potencialidades nas equipas de enfermagem, tendo definido como objetivos: aprofundar conhecimentos sobre Team Building, contextualizar o Team Building no âmbito das teorias organizacionais, descrever diferentes modelos de Team Building e refletir sobre a utilidade do Team Building na qualidade da prestação de cuidados de enfermagem. Deste modo, foram pesquisados artigos na plataforma eletrónica de bases de dados EBSCO, assim como consultada literatura relacionada com a psicologia organizacional. Com a presente pesquisa conclui-se que esta estratégia de dinamização de equipas é útil no âmbito da enfermagem, podendo melhorar a comunicação e relações interpessoais, identificar pontos fortes e fracos das equipas, proporcionar maior satisfação no trabalho e, deste modo, aumentar a qualidade dos cuidados de saúde prestados.En un ambiente de creciente descontento y de imprevisibilidad como el de la enfermería, es cada vez más primordial motivar a los equipos, dándoles competencias personales, relacionales, y, sobre todo, fomentar el trabajo en equipo y consecuentemente la productividad. El Team Building surge así como una estrategia eficaz para lograr resultados positivos. Al ser una estrategia aún poco utilizada en Portugal, se decidió realizar este artículo teórico sobre el asunto y reflexionar sobre la pertinencia y el potencial de los equipos de enfermería, para lo que se definieron los objetivos

  11. Building Extraction from LIDAR Based Semantic Analysis

    Institute of Scientific and Technical Information of China (English)

    YU Jie; YANG Haiquan; TAN Ming; ZHANG Guoning

    2006-01-01

    Extraction of buildings from LIDAR data has been an active research field in recent years. A scheme for building detection and reconstruction from LIDAR data is presented with an object-oriented method which is based on the buildings' semantic rules. Two key steps are discussed: how to group the discrete LIDAR points into single objects and how to establish the buildings' semantic rules. In the end, the buildings are reconstructed in 3D form and three common parametric building models (flat, gabled, hipped) are implemented.

  12. Hanford site post NPH building inspection plan

    Energy Technology Data Exchange (ETDEWEB)

    Wagenblast, G.R., Westinghouse Hanford

    1996-09-12

    This plan establishes consistent post-NPH building inspection procedures and defines a procedure for prioritization of buildings for inspection to ensure the safety of facilities prior to reentry. Qualification of systems for restart of operation is not included. This plan takes advantage, where possible, of existing national procedures for post-NPH inspection of buildings, of existing structural design and evaluation documentation of Hanford facilities, and current and proposed seismic instrumentation located throughout the Hanford site. A list of buildings, prioritized according to current building safety function and building vulnerability (without regard for or information about a damaging natural forces event) is provided.

  13. Building Maintenance in Old Buildings Conservation Approach: An Overview of Related Problems

    OpenAIRE

    Brit Kayan

    2006-01-01

    Building maintenance in conservation of old buildings is one of the approaches applied within the built environment of Malaysia. For instance, it is realised that these old buildings contribute an important significance to our nation's priceless heritage and unique historical development. However, most of these buildings' maintenance is influenced by related problems that affect the overall building conservation approach. Therefore, these old buildings face problems which greatly affect their...

  14. Disease specific methods for economic evaluations of breast cancer therapies

    NARCIS (Netherlands)

    Frederix, G.W.J.

    2013-01-01

    Cost-effectiveness analyses (CEAs) are widely considered to be helpful tools for making informative decisions in a resource constrained environment. Since the introduction of economic evaluations in reimbursement submissions in Australia as a formal requirement in 1993, CEAs have become widespread w

  15. Disease-specific clinical problems associated with the subchondral bone

    NARCIS (Netherlands)

    D. Pape; G. Filardo; E. Kon; C.N. van Dijk; H. Madry

    2010-01-01

    The subchondral bone is involved in a variety of diseases affecting both the articular cartilage and bone. Osteochondral defects in distinct locations and of variable sizes are the final results of different etiologies. These include traumatic osteochondral defects, osteochondritis dissecans, osteon

  16. buildings

    Directory of Open Access Journals (Sweden)

    Wang Hui

    2016-01-01

    Full Text Available In the formation of the blasting seismic wave transmission is a complex mechanical process. Blasting seismic wave in different geological structure formation of the interface, diffraction, reflection, projection as the incident Angle is different, all kinds of waveform transformation, formation of different types, different amplitude, frequency and phase of various wave superimposition of random composite wave. Blasting seismic wave propagation distance (horizontal distance and height difference, and the performance of the explosive, explosive charge, charge structure, priming method, congestion state what international airport, the plane and direction, topography and geological conditions will affect the blasting vibration effect. In engineering by empirical formula to estimate main parameters of blasting seismic wave and the structure of the empirical formula is the result of the use of theoretical analysis, by blasting of similar rate to determine the parameters in the formula is made up of many engineering measured data from statistical analysis, or directly by the measured parameters of the blasting seismic wave is given. In this paper, through various points were set in the prison line large speed is the most value, using the mathematical statistics regression analysis method, attenuation coefficient is obtained, and then back to the formula of single ring allows maximum dose safety distance calculated.

  17. U.S. Department of Energy Commercial Reference Building Models of the National Building Stock

    Energy Technology Data Exchange (ETDEWEB)

    Deru, M.; Field, K.; Studer, D.; Benne, K.; Griffith, B.; Torcellini, P.; Liu, B.; Halverson, M.; Winiarski, D.; Rosenberg, M.; Yazdanian, M.; Huang, J.; Crawley, D.

    2011-02-01

    The U.S. Department of Energy (DOE) Building Technologies Program has set the aggressive goal of producing marketable net-zero energy buildings by 2025. This goal will require collaboration between the DOE laboratories and the building industry. We developed standard or reference energy models for the most common commercial buildings to serve as starting points for energy efficiency research. These models represent fairly realistic buildings and typical construction practices. Fifteen commercial building types and one multifamily residential building were determined by consensus between DOE, the National Renewable Energy Laboratory, Pacific Northwest National Laboratory, and Lawrence Berkeley National Laboratory, and represent approximately two-thirds of the commercial building stock.

  18. Building energy efficiency in rural China

    International Nuclear Information System (INIS)

    Rural buildings in China now account for more than half of China's total building energy use. Forty percent of the floorspace in China is in rural villages and towns. Most of these buildings are very energy inefficient, and may struggle to provide for basic needs. They are cold in the winter, and often experience indoor air pollution from fuel use. The Chinese government plans to adopt a voluntary building energy code, or design standard, for rural homes. The goal is to build on China's success with codes in urban areas to improve efficiency and comfort in rural homes. The Chinese government recognizes rural buildings represent a major opportunity for improving national building energy efficiency. The challenges of rural China are also greater than those of urban areas in many ways because of the limited local capacity and low income levels. The Chinese government wants to expand on new programs to subsidize energy efficiency improvements in rural homes to build capacity for larger-scale improvement. This article summarizes the trends and status of rural building energy use in China. It then provides an overview of the new rural building design standard, and describes options and issues to move forward with implementation. - Highlights: • Building energy use is larger in rural China than in cities. • Rural buildings are very energy intensive, and energy use is growing with incomes. • A new design standard aims to help rural communities build more efficiently. Important challenges remain with implementation

  19. BUILDING AN EFFECTIVE SALES FORCE

    Directory of Open Access Journals (Sweden)

    Ioana Olariu

    2016-07-01

    Full Text Available Building an effective sales force starts with selecting good salespeople, but good salespeople are very difficult to find. The reason for this is that most sales jobs are very demanding and require a great deal from the salesperson. There are many different types of sales jobs. Before it can hire salespeople, each company must do a careful job analysis to see what particular types of selling and other skills are necessary for each sales job. One task of the market planner is to establish clear objectives each year for the entire sales force, for each region, each sales office, and each salesperson. Sales jobs are different from in-house jobs in some significant ways. Nevertheless, each company must continually work on building and maintaining an effective sales force using the following steps: recruitment, selection, training, compensation and evaluation of each salesperson.

  20. Build your own time machine

    CERN Document Server

    Clegg, Brian

    2012-01-01

    There is no physical law to prevent time travel nothing in physics to say it is impossible. So who is to say it can't be done? In Build Your Own Time Machine, acclaimed science writer Brian Clegg takes inspiration from his childhood heroes, Doctor Who and H. G. Wells, to explain the nature of time. How do we understand it and why measure it the way we do? How did the theories of one man change the way time was perceived by the world? Why wouldn't H. G. Wells's time machine have worked? And what would we need to do to make a real one? Build Your Own Time Machine explores the amazing possib

  1. Building bridges … and accelerators

    CERN Multimedia

    2009-01-01

    Lyn Evans, the LHC project leader, was awarded an honorary doctorate from the University of Geneva (UNIGE) to celebrate his role not just in building accelerators, but also in building bridges between nations. He was one of four notables honoured at the event on Friday 5 June, coinciding with the University’s 450th Anniversary. Lyn Evans arriving at the ceremony with Archbishop Desmond Tutu. "It was a big surprise when I found out I’d been nominated," recounts Evans, "but it was an even bigger surprise to find out with whom I’d been nominated". At the ceremony Evans was awarded the honorary doctorate along with three others: Archbishop Desmond Tutu, who was acclaimed for his fight against apartheid in South Africa, Mary Robinson, first woman president of Ireland and former United Nations’ high commissioner of human rights, and Pascal Lamy, Director-General of the World Trade Organization. The award ceremony, known as the �...

  2. Partnerships in Nordic Building Industry

    DEFF Research Database (Denmark)

    , the functioning of specific partnering tools, knowledge management, training etc. Whereas the growth of partnering in all of the Nordic construction industries has developed from inspiration from the UK, and from other Nordic countries, it is the overall impression that partnering is interpreted, implemented......The project had two main objectives. The first was to establish a Nordic network of people and organisations interested in partnerships and partnering in the building industry in order to facilitate the exchange of experiences and new ideas. This objective was met through a series of workshops......, an identification of different approaches and types of partner-ships in the Nordic, and a description of their main characteristics. Moreover the national case studies in the five Nordic countries analysed different aspects of partnering and partnerships in Nordic building industry such as life cycle aspects...

  3. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. The first...... part of the Thesis consists of a theory and literature review on the moisture storage and transport processes (Chapter 2), on the non-Fickian moisture transport (Chapter 3)and on the methods for determining the moisture properties (Chapter 4). In the second part, the conducted experimental work......The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...

  4. Cold Climate Building Enclosure Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Kosny, J.; Fallahi, A.; Shukla, N.

    2013-01-01

    This project investigates the energy performance and cost effectiveness of several state-of-the-art retrofit strategies that could be used in triple-deckers and colonial houses, common house types in New England. Several emerging building enclosure technologies were integrated, including high R-value aerogel and vacuum insulations, in forms that would be energy efficient, flexible for different retrofit scenarios, durable, and potentially cost-competitive for deep energy retrofits.

  5. Building brands without mass media.

    Science.gov (United States)

    Joachimsthaler, E; Aaker, D A

    1997-01-01

    Costs, market fragmentation, and new media channels that let customers bypass advertisements seem to be in league against the old ways of marketing. Relying on mass media campaigns to build strong brands may be a thing of the past. Several companies in Europe, making a virtue of necessity, have come up with alternative brand-building approaches and are blazing a trail in the post-mass-media age. In England, Nestlé's Buitoni brand grew through programs that taught the English how to cook Italian food. The Body Shop garnered loyalty with its support of environmental and social causes. Cadbury funded a theme park tied to its history in the chocolate business. Häagen-Dazs opened posh ice-cream parlors and got itself featured by name on the menus of fine restaurants. Hugo Boss and Swatch backed athletic or cultural events that became associated with their brands. The various campaigns shared characteristics that could serve as guidelines for any company hoping to build a successful brand: senior managers were closely involved with brand-building efforts; the companies recognized the importance of clarifying their core brand identity; and they made sure that all their efforts to gain visibility were tied to that core identity. Studying the methods of companies outside one's own industry and country can be instructive for managers. Pilot testing and the use of a single and continuous measure of brand equity also help managers get the most out of novel approaches in their ever more competitive world. PMID:10174453

  6. Nation-Building through War

    OpenAIRE

    Nicholas Sambanis; Stergios Skaperdas; William Wohlforth

    2014-01-01

    How do the outcomes of international wars affect domestic social change? In turn, how do changing patterns of social identification and domestic conflict affect a nation's military capability? Models that link structural variables, power politics, and the individuals that constitute states are in problematically short supply. We begin to address this gap with a model that draws on experimental results in social psychology and behavioral economics to recapture a lost building block of the clas...

  7. Institution Building for African Regionalism

    OpenAIRE

    Khadiagala, Gilbert M.

    2011-01-01

    Since the 1960s, African states have embraced regional integration as a vital mechanism for political cooperation and for pooling resources to overcome problems of small and fragmented economies. In building meaningful institutions for regionalism, however, Africans have faced the challenges of reconciling the diversities of culture, geography, and politics. As a result, African regional institutions are characterized by multiple and competing mandates and weak institutionalization. This stud...

  8. Brand Building of Born Globals

    OpenAIRE

    Cederäng, Jesper; Norberg, Markus

    2008-01-01

    Abstract The purpose of this thesis was to increase the understanding of two early internationalizing firms (Born Globals) brand building efforts. By performing case studies on these companies we wished to discover similarities and differences in their marketing efforts. The companies that we studied were CTEK Sweden AB, a battery charger manufacturer and POC Sweden AB, who designs advanced protective gear for the alpine ski market. The theoretical framework was divided according to the four ...

  9. Fungi isolated in school buildings

    OpenAIRE

    Elżbieta Ejdys

    2013-01-01

    The aim of the study was to determine the species composition of fungi occurring on wall surfaces and in the air in school buildings. Fungi isolated from the air using the sedimentation method and from the walls using the surface swab technique constituted the study material. Types of finish materials on wall surfaces were identified and used in the analysis. Samples were collected in selected areas in two schools: classrooms, corridors, men's toilets and women's toilets, cloakrooms, sports c...

  10. Optimization of Pre Engineered Buildings

    OpenAIRE

    B K Raghu Prasad; Sunil kumar

    2014-01-01

    Pre-engineered buildings have become quite popular in the last few years. The main advantages are speed of construction and good control over quality. However there is not much information on its economy. There are several parameters like the inclination of the gable, spans, bay spacing, which control the cost of the structure. In the present paper the above parameters are varied systematically and in each case the gable frame designed for the common loads DL, LL, EQ, and WL. ...

  11. Worlds meet in Building 180.

    CERN Multimedia

    Raphael Vuillermet

    In the assembly hall of Building 180, several teams of various nationalities and different countries work together for the ATLAS forward muon detector. For nearly two years, Americans, Chinese, Europeans, Israelis, Japanese, Pakistanis and Russians are assembling and testing the so-called "Big Wheels" and the muon EIL4 stations. Each team is independent in its tasks: one team is assembling the mechanical structure, another one is installing services and muon chambers, while a third is testing the electronics and the gas system. A team is in charge of the transport and storage of the sectors and another is assembling the sectors in the ATLAS cavern. A total of nearly 60 people are participating in this project. Some members for the ATLAS Big Wheel team in the assembly hall of building 180. People from different cultures and religions and with different mother tongues are working side by side in harmony. Everyone in building 180, from technicians to professors, has the opportunity to meet and work with...

  12. Extensive renovation the pathology of heritage building

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2015-01-01

    The pathology of heritage buildings is often related to renovation initiatives typically initiated by implementing energy savings measures.......The pathology of heritage buildings is often related to renovation initiatives typically initiated by implementing energy savings measures....

  13. Analysis of building energy efficiency in China

    Institute of Scientific and Technical Information of China (English)

    LIDeying; FANYun; HAOBin

    2003-01-01

    This paper analyzes the matter of building energy efficiency and heating system, and puts forward the measure of heating innovation, aiming at the improvement of Chinese building energy efficiency and heating innovation, which exceeds some possible advice for future development.

  14. HSIP New Mexico State Government Buildings

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This dataset includes buildings occupied by the headquarters of cabinet level state government executive departments, legislative offices buildings outside of the...

  15. Energy Conservation for Public Office Buildings

    Science.gov (United States)

    Roush, Larry F.

    1973-01-01

    The energy conservation policy for public office buildings includes experimental designs of new federal office buildings in Manchester, New Hampshire and Saginaw, Michigan, as well as immediate energy conservation efforts. (Author/MF)

  16. Extensive renovation the pathology of heritage buildings

    DEFF Research Database (Denmark)

    Rasmussen, Torben Valdbjørn

    2015-01-01

    The pathology of heritage buildings is often related to renovation initiatives typically initiated by implementing energy savings measures.......The pathology of heritage buildings is often related to renovation initiatives typically initiated by implementing energy savings measures....

  17. Computer image of the new Building 42

    CERN Multimedia

    2008-01-01

    The new Building 42, a new extension to building 40, will make extra space for physicists working on the LHC experiments. The project, which is managed by the TS Civil Engineering Group, will be finished in autumn 2010.

  18. Radon Exhalation Considered in Building Material Standard

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>In order to investigate the relationship between radon exhalation and specific activity of natural nuclides in building material, here different kinds of samples of building materials were measured by the

  19. McNamara Life Sciences Building

    Data.gov (United States)

    Federal Laboratory Consortium — Description/History: General purpose laboratory test building The McNamara Life Sciences building allows scientists to manage and execute the Department of Defense...

  20. Marketing strategy of competitiveness management building enterprise

    Directory of Open Access Journals (Sweden)

    A.O. Vasilichenko

    2011-12-01

    Full Text Available In article is elaborated system category and notional device of the competitive studies in condition of the building branch in intercoupling with methods of the realization to strategies of the development. The author is motivated practicability of the use the methods of marketing in competitiveness management building enterprise and is presented author's model managerial system by competitiveness of the building enterprise with provision for specifics of the diagnostics of the processes of the development enterprise to building branch.

  1. Building performance based on measured data

    OpenAIRE

    Andersson, Staffan; Sjögren, Jan-Ulric; Östin, Ronny; Olofsson, Thomas

    2011-01-01

    With increasing liability for builders, the need for evaluation methods that focuses on the building’s performance and thus excludes the impact from residents’ behavior increases. This is not only of interest for new buildings but also when retrofitting existing buildings in order to reduce energy end-use. The investigation in this paper is based on extensive measurements on two fairly representative type of buildings, a single family building in Ekerö, Stockholm built 2000 and two apartment ...

  2. Jackson Park Hospital Green Building Medical Center

    Energy Technology Data Exchange (ETDEWEB)

    Dorsey, William [Jackson Park Hospital Foundation, Chicago, IL (United States); Vasquez, Nelson [Jackson Park Hospital Foundation, Chicago, IL (United States)

    2010-05-01

    Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago's recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work.

  3. Renewable Energy Applications for Existing Buildings: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Hayter, S. J.; Kandt, A.

    2011-08-01

    This paper introduces technical opportunities, means, and methods for incorporating renewable energy (RE) technologies into building designs and operations. It provides an overview of RE resources and available technologies used successfully to offset building electrical and thermal energy loads. Methods for applying these technologies in buildings and the role of building energy efficiency in successful RE projects are addressed along with tips for implementing successful RE projects.

  4. Impact of tall buildings in environmental pollution

    OpenAIRE

    H. Hayati; M.H. Sayadi

    2012-01-01

    Today, tall building is a phenomenon that the world particularly large cities are facing. The tall buildings in order to exploit the land with having the negative affects in the environment create new problems including increasing congestion population, environmental pollution, reduce citizen access to fresh air and sunlight. However, regarding to population increasing and land shortage, tall buildings could not be avoided. This paper investigates the relationship of tall buildings with urban...

  5. GEM Building Taxonomy (Version 2.0)

    Science.gov (United States)

    Brzev, S.; Scawthorn, C.; Charleson, A.W.; Allen, L.; Greene, M.; Jaiswal, Kishor; Silva, V.

    2013-01-01

    This report documents the development and applications of the Building Taxonomy for the Global Earthquake Model (GEM). The purpose of the GEM Building Taxonomy is to describe and classify buildings in a uniform manner as a key step towards assessing their seismic risk, Criteria for development of the GEM Building Taxonomy were that the Taxonomy be relevant to seismic performance of different construction types; be comprehensive yet simple; be collapsible; adhere to principles that are familiar to the range of users; and ultimately be extensible to non-buildings and other hazards. The taxonomy was developed in conjunction with other GEM researchers and builds on the knowledge base from other taxonomies, including the EERI and IAEE World Housing Encyclopedia, PAGER-STR, and HAZUS. The taxonomy is organized as a series of expandable tables, which contain information pertaining to various building attributes. Each attribute describes a specific characteristic of an individual building or a class of buildings that could potentially affect their seismic performance. The following 13 attributes have been included in the GEM Building Taxonomy Version 2.0 (v2.0): 1.) direction, 2.)material of the lateral load-resisting system, 3.) lateral load-resisting system, 4.) height, 5.) date of construction of retrofit, 6.) occupancy, 7.) building position within a block, 8.) shape of the building plan, 9.) structural irregularity, 10.) exterior walls, 11.) roof, 12.) floor, 13.) foundation system. The report illustrates the pratical use of the GEM Building Taxonomy by discussing example case studies, in which the building-specific characteristics are mapped directly using GEM taxonomic attributes and the corresponding taxonomic string is constructed for that building, with "/" slash marks separating attributes. For example, for the building shown to the right, the GEM Taxonomy string is: DX1/MUR+CLBRS+MOCL2/LWAL3/

  6. SYSTEM ORGANIZATION OF MATERIAL PROVIDING OF BUILDING

    Directory of Open Access Journals (Sweden)

    A. V. Rаdkеvich

    2014-04-01

    Full Text Available Purpose. Development of scientific-methodical bases to the design of rational management of material streams in the field of building providing taking into account intersystem connections with the enterprises of building industry. Methodology. The analysis of last few years of functioning of building industry in Ukraine allows distinguishing a number of problems that negatively influence the steady development of building, as the component of the state economics system. Therefore the research of existent organization methods of the system of building objects providing with material resources is extremely necessary. In connection with this the article justifies the use of method of hierarchies analysis (Saati method for finding the optimal task solution of fixing the enterprises of building industry after building objects. Findings. Results give an opportunity to guidance of building organization to estimate and choose advantageous suppliers - enterprises of building industry, to conduct their rating, estimation taking into account basic descriptions, such as: quality, price, reliability of deliveries, specialization, financial status etc. Originality. On the basis of Saati method the methodologies of organization are improved, planning and managements of the reliable system of providing of building necessary material resources that meet the technological requirements of implementation of building and installation works. Practical value. Contribution to the decisions of many intricate organizational problems that are accompanied by the problems of development of building, provided due to organization of the reliable system of purchase of material resources.

  7. 75 FR 20833 - Building Energy Codes

    Science.gov (United States)

    2010-04-21

    ... International Energy Conservation Code (or equivalent) for low- rise residential buildings. DOE is publishing... reductions in building energy use. This is consistent with section 304(d) and (e) of the Energy Conservation... Conservation Code (or equivalent) for residential buildings. Information, materials, and tools necessary...

  8. Asbestos in Buildings: What You Should Know.

    Science.gov (United States)

    Safe Buildings Alliance, Washington, DC.

    Thirty-one critical questions about asbestos, its use in school buildings, and the risks it poses to health are answered in this booklet. Issued by the Safe Buildings Alliance, an incorporated association of manufacturers that once supplied asbestos-containing materials for building construction, the booklet's purpose is to provide information…

  9. Building Regulations 1990 revisions: Pt. L1

    Energy Technology Data Exchange (ETDEWEB)

    Burberry, Peter (Manchester Univ. (UK). Inst. of Science and Technology)

    1990-02-28

    The provisions of Building Regulations L1, ''Limitation of heat loss through the building fabric'', are summarised and discussed. Calculational procedures involving trade off of increased standards in one part of the building against lower standards in another and the setting of energy targets are discussed in relation to thermal insulation. (U.K.).

  10. NBIR seminar: energy conservation in commercial buildings

    Energy Technology Data Exchange (ETDEWEB)

    1979-11-27

    A partial listing of topic areas includes: Designing for optimal thermal performance; Energy management in existing buildings; Total systems design in air conditioning and lighting; Solar water heating; Hot water and space heating installations for a large hostel; Alternative energy sources for the heating and cooling of a building; The architectural approach to energy conservation in an office building.

  11. Indoor air pollution and sick building syndrome

    International Nuclear Information System (INIS)

    The topics discussed in this paper are accept that SBS (Sick building syndrome) is a reality ; understand the dimensions of the problem ; differentiate between sick building syndrome and building related illness ; introduce standards ; understanding the economics ; act pro-actively not re-actively

  12. Conceptual design study of JSFR reactor building

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, T.; Katoh, A.; Chikazawa, Y. [Japan Atomic Energy Agency (JAEA), 4002 Narita, Oarai, Ibaraki 311-1393 (Japan); Ohya, T.; Iwasaki, M.; Hara, H.; Akiyama, Y. [Mitsubishi FBR Systems, Inc. MFBR, 34-17, Jingumae 2-chome, Shibuya, Tokyo 150-0001 (Japan)

    2012-07-01

    Japan Sodium-cooled Fast Reactor (JSFR) is planning to adopt the new concepts of reactor building. One is that the steel plate reinforced concrete is adopted for containment vessel and reactor building. The other is the advanced seismic isolation system. This paper describes the detail of new concepts for JSFR reactor building and engineering evaluation of the new concepts. (authors)

  13. Project materials [Commercial High Performance Buildings Project

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-01-01

    The Consortium for High Performance Buildings (ChiPB) is an outgrowth of DOE'S Commercial Whole Buildings Roadmapping initiatives. It is a team-driven public/private partnership that seeks to enable and demonstrate the benefit of buildings that are designed, built and operated to be energy efficient, environmentally sustainable, superior quality, and cost effective.

  14. Impact of tall buildings in environmental pollution

    Directory of Open Access Journals (Sweden)

    H. Hayati

    2012-03-01

    Full Text Available Today, tall building is a phenomenon that the world particularly large cities are facing. The tall buildings in order to exploit the land with having the negative affects in the environment create new problems including increasing congestion population, environmental pollution, reduce citizen access to fresh air and sunlight. However, regarding to population increasing and land shortage, tall buildings could not be avoided. This paper investigates the relationship of tall buildings with urban air pollution as well as the possible reducing of negative affects of tall building on environmental pollution with respect to geographical position, technicalrules, immunization, green space, direct of wind, appropriate distance to other buildings, design in terms of visibility and landscape and urban appearance were reviewed. The study showed that the tall buildings cause increasing the air pollution in large urban area due to changing in wind and its direction and also congestion of tall buildings as a pollution sources. Therefore some techniques to design the tall building must be considered to reduce the negative affects of the tall buildings on environmental pollution. Unfortunately the lack of the construction roles in term of environmental protection and also control of the rules in construction process causing the environmental pollution particularly air pollution. It is suggested that the re-evaluate of the rules with restricted control can improve the air quality in the large cities and also utilization of green spaces in floors and roofs of buildings as environmentally friendly buildings which are attempt to reduce environmental problems.

  15. Vacuum Insulation Panels Applied in Building Constructions

    NARCIS (Netherlands)

    Tenpierik, M.J.

    2010-01-01

    Due to sustainability and due to international treaties, it is desired and required to reduce greenhouse gas emissions drastically. One contributor to these emissions is the burning of fossil fuels for generating power and electricity to be used in and for buildings. Buildings and building-related p

  16. Energy Conservation in Buildings--A Human Factors/Systems Viewpoint. NBS Building Science Series 88.

    Science.gov (United States)

    Rubin, Arthur I.

    The current emphasis on energy conservation in buildings must be balanced by a careful consideration of how proposed approaches affect building occupants. A headlong rush toward building designs that conserve energy at the expense of the quality of buildings as judged by occupants would be a very shortsighted approach. There must be a continual…

  17. 77 FR 24494 - Office of Federal High-Performance Green Buildings; Green Building Advisory Committee...

    Science.gov (United States)

    2012-04-24

    ... and agenda for the May 9, 2012, meeting of the Green Building Advisory Committee Meeting (the... mission. Agenda: Wednesday, May 9, 2012. Introductions and plans for today's meeting Green building... ADMINISTRATION Office of Federal High-Performance Green Buildings; Green Building Advisory...

  18. 78 FR 21368 - Office of Federal High-Performance Green Buildings; Green Building Advisory Committee...

    Science.gov (United States)

    2013-04-10

    ... provides the schedule and agenda for the May 1, 2013, meeting of the Green Building Advisory Committee... & Plans for Today's Meeting. Climate Change Adaptation. Green Building Certification System Review. Lunch... ADMINISTRATION Office of Federal High-Performance Green Buildings; Green Building Advisory...

  19. BIM. Building Information Model. Special issue; BIM. Building Information Model. Themanummer

    Energy Technology Data Exchange (ETDEWEB)

    Van Gelder, A.L.A. [Arta and Consultancy, Lage Zwaluwe (Netherlands); Van den Eijnden, P.A.A. [Stichting Marktwerking Installatietechniek, Zoetermeer (Netherlands); Veerman, J.; Mackaij, J.; Borst, E. [Royal Haskoning DHV, Nijmegen (Netherlands); Kruijsse, P.M.D. [Wolter en Dros, Amersfoort (Netherlands); Buma, W. [Merlijn Media, Waddinxveen (Netherlands); Bomhof, F.; Willems, P.H.; Boehms, M. [TNO, Delft (Netherlands); Hofman, M.; Verkerk, M. [ISSO, Rotterdam (Netherlands); Bodeving, M. [VIAC Installatie Adviseurs, Houten (Netherlands); Van Ravenswaaij, J.; Van Hoven, H. [BAM Techniek, Bunnik (Netherlands); Boeije, I.; Schalk, E. [Stabiplan, Bodegraven (Netherlands)

    2012-11-15

    A series of 14 articles illustrates the various aspects of the Building Information Model (BIM). The essence of BIM is to capture information about the building process and the building product. [Dutch] In 14 artikelen worden diverse aspecten m.b.t. het Building Information Model (BIM) belicht. De essentie van BIM is het vastleggen van informatie over het bouwproces en het bouwproduct.

  20. Building Software, Building Community: Lessons from the Ropensci Project

    Science.gov (United States)

    Boettiger, C.

    2014-12-01

    rOpenSci is a developer collective originally formed in 2011 by graduate students and post-docs from ecology and evolutionary biology to collaborate on building software tools to facilitate a more open and synthetic approach in the face of transformative rise of large and heterogeneous data. Born on the internet (the collective only began through chance discussions over social media), we have grown into a widely recognized effort that supports an ecosystem of some 45software packages, engages scores of collaborators, has taught dozens of workshops around the world, and has secured over $480,000 in grant support. As young scientists working in an academic context largely without direct support for our efforts, we have first hand experience with most of the the technical and social challenges in developing sustainable scientific software. I will summarize our experiences, the challenges we have faced, and describe our approach and success in building an effective and diverse community around the rOpenSci project.

  1. Capacity Building: Building Human Capital Through Enhanced Science Education

    International Nuclear Information System (INIS)

    The problem Africa is facing is under-development that manifests itself in terms of poverty, diseases, ignorance and many other forms.s It is regrettable to recognize and note that due to severe but an apparent lack of funds and other resources, many african countries have remained impoverished over the years.The weak fiscal status and the dim prospects for drastic economic improvement coupled with mismanagement, corrupt and , at times, despotic regimes in the continent also militate against any significant local support to alleviate the problems of under-development in the near future. From the experience of the industrialized countries, its abundantly clear that for Africa to Develop and survive this century, science and technology must take root in the continent to serve the people and and improve their standards of living by increasing productivity. Its also well understood and recognized that for science and technology to benefit the continent, human resources development , i.e., capacity building in general is paramount and basic. There are a number of Prerequisites for capacity building and these involves issues and questions which must be addressed

  2. Hygrothermal Behavior, Building Pathology and Durability

    CERN Document Server

    Delgado, JMPQ

    2013-01-01

    The main purpose of this book, Hygrothermal, Building Pathology and Durability, is to provide a collection of recent research works to contribute to the systematization and dissemination of knowledge related to construction pathology, hygrothermal behaviour of buildings, durability and diagnostic techniques and, simultaneously, to show the most recent advances in this domain. It includes a set of new developments in the field of building physics and hygrothermal behaviour, durability approach for historical and old buildings and building pathology vs. durability. The book is divided in several chapters that are a resume of the current state of knowledge for benefit of professional colleagues, scientists, students, practitioners, lecturers and other interested parties to network.

  3. Fire safety challenges of green buildings

    CERN Document Server

    Meacham, Brian; Echeverria, Juan; Cheng, Raymond

    2013-01-01

    Environmental concerns and advances in architectural technologies have lead to a greater number of green buildings or buildings with green, eco-friendly elements. However, from a practical standpoint, there is no incident reporting system in the world that tracks data on fire incidents in green buildings. Fire safety objectives are not explicitly considered in most green rating schemes, and green design features have been associated with photovoltaic panels and roof materials, lightweight timber frame buildings, and combustible insulation materials. Fire Safety Challenges of Green Buildings is

  4. Building Place Identity through Heritage

    Directory of Open Access Journals (Sweden)

    Alexandra PACESCU

    2015-12-01

    Full Text Available In an increasingly globalized world, the fading specificity is producing homogeneous images that make cities more and more difficult to tell apart. The market economy tends to commodify each and every aspect of urban life, even those belonging to the cultural realm. As a consequence, a need for differentiators arises, which can be best embodied by the local heritage. The present paper is trying to establish a link between the concept of Place Identity, seen from a marketing point of view, and Heritage, as a key factor to build or emphasize a ‘point of difference’ for ‘a unique selling proposition’. Although ‘brands’ are commonly associated with globalization and its supposed tendency to erase defining characteristics, their marketing principles could prove to be the very solution to regaining the lost specificity, since they help embed local heritage, already an asset, into the ‘mix’ that determines ‘place identity’. Building and promoting an identity is also the endeavor of branding, hence the overlapping of these two concepts. It is therefore useful to examine the evolution of brands from simple marks of identity to entities which develop complex relations with the users. The need for a ‘a unique selling proposition’ that brands have already acknowledged should be considered when building the place identity so much needed by cities in their fierceful competition for attracting activities. Branding through heritage could prove to be a safe bet to reinforce the particular in the globalised market, if correctly managed and planned. Promoting the city and salvaging one of its key differentiators at the same time is, for sure, a win-win situation.

  5. Fungi isolated in school buildings

    Directory of Open Access Journals (Sweden)

    Elżbieta Ejdys

    2013-12-01

    Full Text Available The aim of the study was to determine the species composition of fungi occurring on wall surfaces and in the air in school buildings. Fungi isolated from the air using the sedimentation method and from the walls using the surface swab technique constituted the study material. Types of finish materials on wall surfaces were identified and used in the analysis. Samples were collected in selected areas in two schools: classrooms, corridors, men's toilets and women's toilets, cloakrooms, sports changing rooms and shower. Examinations were conducted in May 2005 after the heating season was over. Fungi were incubated on Czapek-Dox medium at three parallel temperatures: 25, 37 and 40°C, for at least three weeks. A total of 379 isolates of fungi belonging to 32 genera of moulds, yeasts and yeast-like fungi were obtained from 321 samples in the school environment. The following genera were isolated most frequently: Aspergillus, Penicillium and Cladosporium. Of the 72 determined species, Cladosporium herbarum, Aspergillus fumigatus and Penicillium chrysogenum occurred most frequently in the school buildings. Wall surfaces were characterised by an increased prevalence of mycobiota in comparison with the air in the buildings, with a slightly greater species diversity. A certain species specificity for rough and smooth wall surfaces was demonstrated. Fungi of the genera Cladosporium and Emericella with large spores adhered better to smooth surfaces while those of the genus Aspergillus with smaller conidia adhered better to rough surfaces. The application of three incubation temperatures helped provide a fuller picture of the mycobiota in the school environment.

  6. Design Buildings Optimally: A Lifecycle Assessment Approach

    KAUST Repository

    Hosny, Ossama

    2013-01-01

    This paper structures a generic framework to support optimum design for multi-buildings in desert environment. The framework is targeting an environmental friendly design with minimum lifecycle cost, using Genetic Algorithms (Gas). GAs function through a set of success measures which evaluates the design, formulates a proper objective, and reflects possible tangible/intangible constraints. The framework optimizes the design and categorizes it under a certain environmental category at minimum Life Cycle Cost (LCC). It consists of three main modules: (1) a custom Building InformationModel (BIM) for desert buildings with a compatibility checker as a central interactive database; (2) a system evaluator module to evaluate the proposed success measures for the design; and (3) a GAs optimization module to ensure optimum design. The framework functions through three levels: the building components, integrated building, and multi-building levels. At the component level the design team should be able to select components in a designed sequence to ensure compatibility among various components, while at the building level; the team can relatively locate and orient each individual building. Finally, at the multi-building (compound) level the whole design can be evaluated using success measures of natural light, site capacity, shading impact on natural lighting, thermal change, visual access and energy saving. The framework through genetic algorithms optimizes the design by determining proper types of building components and relative buildings locations and orientations which ensure categorizing the design under a specific category or meet certain preferences at minimum lifecycle cost.

  7. Sustainability and cultural heritage buildings

    OpenAIRE

    Lourenço, Paulo B.; Branco, Jorge M.; Ana C. Coelho

    2015-01-01

    [Excerpt from Introduction] Conservation of cultural heritage buildings is a demand from society, which recognizes this heritage as a part of their identity, but it is also an economical issue. In Europe, tourism accounts for 10% of the GDP and 12% of the employment, if linked sectors are considered [x.1]. The EU is the world's number one tourist destination, with 40 % of arrivals in the world and with 7 European countries among the top ten [x.2]. According to the WTO estimates, international...

  8. Frost resistance of building materials

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan De Place

    materials, has been developed.The importance of the pore structure on the development of stresses in the material during freezing is emphasized. To verify the model, experimental investigations are made on various concretes without air-entrainment and brick tiles with different porosities.Calculations......In this thesis it is shown that the critical degree of saturation is suitable as parameter for the frost resistance of porous building materials. A numerical model for prediction of critical degrees of saturation based on fracture mechanics and phase geometry of two-phase materials, e.g. porous...

  9. Building the Realtime User Experience

    CERN Document Server

    Roden, Ted

    2010-01-01

    The Web is increasingly happening in realtime. With websites such as Facebook and Twitter leading the way, users are coming to expect that all sites should serve content as it occurs -- on smartphones as well as computers. This book shows you how to build realtime user experiences by adding chat, streaming content, and including more features on your site one piece at a time, without making big changes to the existing infrastructure. You'll also learn how to serve realtime content beyond the browser. Throughout the book are many practical JavaScript and Python examples that you can use on yo

  10. Fayette County Better Buildings Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Capella, Arthur

    2015-03-04

    The Fayette County Better Buildings Initiative represented a comprehensive and collaborative approach to promoting and implementing energy efficiency improvements. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. The ultimate goal of Fayette County’s Better Buildings Initiative was to implement a total of 1,067 residential energy efficiency retrofits with a minimum 15% estimated energy efficiency savings per unit. Program partners included: United States Department of Energy, Allegheny Power, and Private Industry Council of Westmoreland-Fayette, Fayette County Redevelopment Authority, and various local partners. The program was open to any Fayette County residents who own their home and meet the prequalifying conditions. The level of assistance offered depended upon household income and commitment to undergo a BPI – Certified Audit and implement energy efficiency measures, which aimed to result in at least a 15% reduction in energy usage. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. Additionally, the program had components that involved recruitment and training for employment of persons in the energy sector (green jobs), as well as marketing and implementation of a commercial or community facilities component. The residential component of Fayette County’s Better Buildings Initiative involved a comprehensive approach, providing assistance to low- moderate- and market-rate homeowners. The initiative will also coordinate activities with local utility providers to further incentivize energy efficiency improvements among qualifying homeowners. The commercial component of Fayette County’s Better Building Initiative involved grants

  11. Team building and diagnostic training

    International Nuclear Information System (INIS)

    While developing a commercial training program to improve teamwork in control room crews, General Electric's Nuclear Training Services made an important discovery. Traditional training methods for developing teamwork and enhancing diagnostics capabilities are incomplete. Traditional methods generally help, but fail to fulfill the long-term needs of most teams. Teamwork has been treated as a short-term performance problem. Traditional diagnostic training suffers from a similar problem. Too often, it covers only the basic principles of decision-making, ignoring the development of expert diagnostic capabilities. In response to this discovery, they have developed comprehensive training in Team Building and Diagnostics

  12. Capacity Building for Engineering Education

    DEFF Research Database (Denmark)

    de Graaff, Erik; Deboer, Jennifer

    2015-01-01

    The International Institute for Developing Engineering Academics (IIDEA) is a joint initiative from IFEES and SEFI, aiming to provide all the engineering education associations, institutions and other engineering education stakeholders a clearing house of high caliber and world-class engineering ...... and universities are being challenged to incorporate innovative tools in their classrooms as well as to prepare students to research and innovate themselves. The paper will present an overview of IIDEA activities and aims to evaluate the success of the capacity building workshops....

  13. NASA Innovation Builds Better Nanotubes

    Science.gov (United States)

    2008-01-01

    Nanotailor Inc., based in Austin, Texas, licensed Goddard Space Flight Center's unique single-walled carbon nanotube (SWCNT) fabrication process with plans to make high-quality, low-cost SWCNTs available commercially. Carbon nanotubes are being used in a wide variety of applications, and NASA's improved production method will increase their applicability in medicine, microelectronics, advanced materials, and molecular containment. Nanotailor built and tested a prototype based on Goddard's process, and is using this technique to lower the cost and improve the integrity of nanotubes, offering a better product for use in biomaterials, advanced materials, space exploration, highway and building construction, and many other applications.

  14. Integrating CFD and building simulation

    DEFF Research Database (Denmark)

    Bartak, M.; Beausoleil-Morrison, I.; Clarke, J.A.;

    2002-01-01

    To provide practitioners with the means to tackle problems related to poor indoor environments, building simulation and computational 3uid dynamics can usefully be integrated within a single computational framework. This paper describes the outcomes from a research project sponsored by the European...... Commission, which furthered the CFD modelling aspects of the ESP-r system. The paper summarises the form of the CFD model, describes the method used to integrate the thermal and 3ow domains and reports the outcome from an empirical validation exercise. © 2002 Published by Elsevier Science Ltd....

  15. Fuelling innovation in building design.

    Science.gov (United States)

    Baillie, Jonathan

    2012-08-01

    Established in 2005 on a 78-acre site near Watford by a research-based consultancy, testing, and training organisation with a reputation for independence and impartiality, the BRE's Watford Innovation Park is today home to a broad range of research, consultancy, and testing activities, for the built environment. HEJ editor, Jonathan Baillie, met with BRE director of Strategic Research, Peter Ball, to learn about the organisation's history and current-day activities, and tour of some of the key facilities where staff undertake cutting-edge research, consultancy, and testing, to improve the performance, efficiency, and sustainability, of a wide range of buildings.

  16. A Building Connecting Separated Communities

    DEFF Research Database (Denmark)

    Axel, Erik

    abroad was constructed by different professional groups architects/engineers/craft persons, and how it was used by some groupings of students. In the beginning of the construction process our interviews with the architects revealed that the architect designing the house collaborated with an architect...... with students from other dormitories, and connect with the Danes from other sections of the building isolating themselves. The janitor was surprised at the supposed function of the washing machines. Since other dormitories at the campus did not provide washing machines, the ones at the house investigated were...

  17. Domain Building or Risk Taking

    DEFF Research Database (Denmark)

    Hjort, Katrin; Abrahamsen, Marianne

    2012-01-01

    in school management. Among headmasters in High school in Denmark only 18 % are women despite of the fact that 52 % of the teachers are female. How can we explain that? This article is based on a survey answered by top- and middle level management staff. It rejects all traditional explanations...... of the relations between gender, values and family obligation but reveals an interesting difference between two strategies for career development: Domain Building and Risk Taking. Both strategies are applied by both men and women. However, one of them seems to be the most effective with regard to achieve...

  18. Optimization of Pre Engineered Buildings

    Directory of Open Access Journals (Sweden)

    B K Raghu Prasad

    2014-09-01

    Full Text Available Pre-engineered buildings have become quite popular in the last few years. The main advantages are speed of construction and good control over quality. However there is not much information on its economy. There are several parameters like the inclination of the gable, spans, bay spacing, which control the cost of the structure. In the present paper the above parameters are varied systematically and in each case the gable frame designed for the common loads DL, LL, EQ, and WL. The quantity in each case is obtained and finally the structure which regulates the lowest quantity of steel is recommended.

  19. A new building for testing magnets

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    A ceremony to mark the laying of the foundation stone of Building 311, which will house a magnetic measurement laboratory, took place on 22 September.   Olaf Dunkel, head of the Building 311 project, José Miguel Jiménez, head of the Technology Department, and Lluis Miralles, head of the Site Management and Buildings Department, during the ceremony for the laying of the foundation stone of Building 311. Lluis Miralles, head of the Site Management and Buildings Department, José Miguel Jiménez, head of the Technology Department, Roberto Losito, head of the Engineering Department, and Simon Baird, head of the Occupational Health and Safety and Environmental Protection Unit, officially laid the foundation stone of Building 311 during a ceremony on Thursday, 22 September. Situated beside the water tower, the building will house a magnetic measurement laboratory for the Technology Department. With a floor space of around 1400 square metres, it will comprise a...

  20. Integrated sustainable urban infrastructures in building projects

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Quitzau, Maj-Britt; Elle, Morten;

    2007-01-01

    Current strategies in urban planning and development merely promote standardized building solutions, while failing to prioritize innovative approaches of integration between building projects and sustainable urban infrastructures. As a result of this, urban infrastructures – the urban veins...... – are outdated from a sustainability perspective. This paper looks into more holistic ways of approaching building projects and discuss whether this provide a basis for an increased integration of urban infrastructures within building projects. In our study, we especially emphasise how conventional ways...... of approaching building projects are influenced by lock-in of existing infrastructural systems and compare this with two examples of more holistic ways of approaching building projects, developed by two architecture firms. The paper points out that such holistic perspective in building projects provide...

  1. Actual service life prediction of building components

    DEFF Research Database (Denmark)

    Aagaard, Niels-Jørgen; Brandt, Erik; Hansen, Ernst Jan de Place

    2014-01-01

    , the paper presents an analysis of service life of buildings as such with respect to the use of the building partially based on analysis of data from the nationwide Danish register of buildings and housing as well as turnover in the Danish construction industry from refurbishment and demolition activities...... a condensed method for assessment of life cycle costs for buildings. Estimation of life cycle costs has traditionally been based on predicted service life for building components in terms of technical performance. This paper suggests a method for taking into account other contributing factors...... such as economics, aesthetics and use of the building. Each of these factors is regarded as a stochastic variable and can be seen as competing causes of bringing service life to an end. A model is proposed for combining such variables resulting in the actual service life of building components. Furthermore...

  2. Hygrothermal behavior, building pathology and durability

    Energy Technology Data Exchange (ETDEWEB)

    Peixoto de Freitas V.; Delgado, J.M.P.Q. (eds.) [Porto Univ. (Portugal). Building Physics Lab.

    2013-03-01

    Includes a set of new developments in the field of building physics and hygrothermal behavior. Presents a new durability approach for historical and old buildings. Reviews the current state of knowledge. The main purpose of this book, Hygrothermal, Building Pathology and Durability, is to provide a collection of recent research works to contribute to the systematization and dissemination of knowledge related to construction pathology, hygrothermal behaviour of buildings, durability and diagnostic techniques and, simultaneously, to show the most recent advances in this domain. It includes a set of new developments in the field of building physics and hygrothermal behaviour, durability approach for historical and old buildings and building pathology vs. durability. The book is divided in several chapters that are a resume of the current state of knowledge for benefit of professional colleagues, scientists, students, practitioners, lecturers and other interested parties to network.

  3. Energetic Refurbishment of Historic Brick Buildings

    DEFF Research Database (Denmark)

    Zagorskas, Jurgis; Mykolas Paliulis, Grazvydas; Burinskiene, Marija;

    2013-01-01

    covers the theme of refurbishment measures in historical buildings – the specific measures like inside insulation which are allowed due to the valuable façade or other heritage preservation requirements. An overview of other innovative methods for energy saving in existing buildings and their potential......Building standards for energy effectiveness are increasing constantly and the market follows these changes by constructing new buildings in accordance with standards and refurbishment of the existing housing stock. Comprehensive trends in European construction market show tremendous increase...... is creating a demand for suitable materials, retrofitting techniques and research. The differences between refurbishment of new-build projects and historical or valuable buildings are insufficiently recognized – mostly the buildings without further cultural preservation requirements are studied. This article...

  4. Occupant behaviour and robustness of building design

    DEFF Research Database (Denmark)

    Buso, Tiziana; Fabi, Valentina; Andersen, Rune Korsholm;

    2015-01-01

    with alternating occupant behaviour patterns. The aim of this work was to investigate how alternating occupant behaviour patterns impact the performance of different envelope design solutions in terms of building robustness. Probabilistic models of occupants' window opening and use of shading were implemented......Occupant behaviour can cause major discrepancies between the designed and the real total energy use in buildings. A possible solution to reduce the differences between predictions and actual performances is designing robust buildings, i.e. buildings whose performances show little variations...... in a dynamic building energy simulation tool (IDA ICE). The analysis was carried out by simulating 15 building envelope designs in different thermal zones of an Office Reference Building in 3 climates: Stockholm, Frankfurt and Athens.In general, robustness towards changes in occupants' behaviour increased...

  5. Building Information Modelling in Denmark and Iceland

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Jóhannesson, Elvar Ingi

    2013-01-01

    Purpose – The purpose of this paper is to explore the implementation of building information modelling (BIM) in the Nordic countries of Europe with particular focus on the Danish building industry with the aim of making use of its experience for the Icelandic building industry. Design....../methodology/aptroach – The research is based on two separate analyses. In the first part, the deployment of information and communication technology (ICT) in the Icelandic building industry is investigated and compared with the other Nordic countries. In the second part the experience in Denmark from implementing and working...... for making standards and guidelines related to BIM. Public building clients are also encouraged to consider initiating projects based on making simple building models of existing buildings in order to introduce the BIM technology to the industry. Icelandic companies are recommended to start implementing BIM...

  6. Thermally activated building systems in context of increasing building energy efficiency

    OpenAIRE

    Stojanović Branislav V.; Janevski Jelena N.; Mitković Petar B.; Stojanović Milica B.; Ignjatović Marko G.

    2014-01-01

    One of the possible ways to provide heating to the building is to use thermally activated building systems. This type of heating, besides providing significant increase in building energy efficiency, allows using low-temperature heating sources. In this paper, special attention is given to opaque part of the building façade with integrated thermally activated building systems. Due to fact that this type of system strongly depends on temperature of this cons...

  7. Build Your Own Particle Detector

    CERN Document Server

    Mehlhase, Sascha; The ATLAS collaboration

    2016-01-01

    To support the outreach activities of ATLAS institutes and to grasp people’s attention in science exhibitions and during public events, a very detailed model of the experiment built entirely out of LEGO bricks as well as an outreach programme using LEGO bricks to get people to think about particle detectors and involve them into a conversation about particle physics in general have been created. A large LEGO model, consisting of about 9500 pieces, has been exported to more than 55 ATLAS institutes and has been used in numerous exhibitions to explain the proportion and composition of the experiment to the public. As part of the Build Your Own Particle Detector programme (byopd.org) more than 15 events have been conducted, either involving a competition to design and build the best particle detector from a random pile of pieces or to take part in the construction of one of the large models, as part of a full day outreach event. Recently, miniature models of all four main LHC experiments, that will be used at ...

  8. Build Your Own Particle Detector

    CERN Document Server

    Mehlhase, Sascha; The ATLAS collaboration

    2016-01-01

    To support the outreach activities of Atlas institutes and to grab people's attention in science exhibitions and during public events, we have created both a very detailed model of the experiment built entirely out of about Lego bricks as well as an outreach programme using Lego bricks to get people to think about particle detectors and involve them into a conversation about particle physics in general. A large Lego model, consisting of about 9500 pieces, has been 'exported' to more than 55 Atlas institutes and has been used in numerous exhibitions to explain the proportion and composition of the experiment to the public. As part of 'Build Your Own Particle Detector' programme (byopd.org) we conducted more than 15 events,either involving a competition to design and build the 'best' particle detector from a random pile of pieces or to take part in the construction of one of the large models, as part of a full day outreach event. Recently we've added miniature models of all four LHC experiments, that will be us...

  9. BUILDING STRONGER STATE ENERGY PARTNERSHIPS

    Energy Technology Data Exchange (ETDEWEB)

    David Terry

    2002-04-22

    When initiated by the National Association of State Energy Officials (NASEO) and the U.S. Department of Energy's (DOE) Rebuild America Program (RBA), this project--Strengthening the Partnerships Between the State and Territory Energy Offices and the U.S. Department of Energy--was geared toward addressing some project development and communications barriers between the State Energy Offices and the RBA program. While successful in some states, RBA officials were having difficulty assisting states in forming partnerships with communities and taking advantage of the programs technical assistance and other resources. NASEO's efforts under the project were, in large part, aimed at educating state energy offices about RBA's resources and delivering timely information to help move the program forward by emphasizing the successes of key states and identifying concerns and problems in states beginning to implement RBA activities. This report defines these outreach needs and challenges, the tasks designed to address these issues, and results during the first year of the project. As contemplated in NASEO's workplan, the approach during the first year of the agreement focuses on working through NASEO's State Energy Committee structure. Support provided under the agreement for tasks one and two during year one was intended to address partnerships in the buildings area. Specifically, NASEO was to work with its buildings committee, various state energy office members, and the Rebuild America program to improve partnership efforts, communications, and effectiveness of these combined efforts. The approach of to the project included three elements during year one. First, NASEO and its Buildings Committee were to focus on raising awareness and coordination of Rebuild activities. Through education, one-on-one communications, and presentations at NASEO meetings and other events, staff and the committee will assist Rebuild officials in stimulating interest in the

  10. Building the new schoolhouse: the Massachusetts school building authority.

    Science.gov (United States)

    Ames, Jennifer; Levenstein, Charles

    2013-01-01

    In a 2010 special issue of New Solutions on school health and environment, Paulson and Barnett asked who is responsible for the environmental health of schools. The Massachusetts School Building Authority (MSBA), the product of liberals trying to bring organization and efficiency to school construction, is an "off-label" and only partial answer to the question. The MSBA, established in 2004, lent its ear to health and safety advocates who seized an opportunity to implement regulations, guidelines, and education reforms at the level of school construction. The MSBA's progressiveness is a model to localities and states across the United States facing the dual crisis of attacks on public education and financial inefficiency. However, the MSBA is still in its infancy. Time will tell whether the MSBA, viewed as a limited state pilot program, can survive and expand its environmental health programs or whether its initiative is only as good as its current leadership.

  11. Environmental impacts during the operational phase of residential buildings

    NARCIS (Netherlands)

    Blom, I.S.

    2010-01-01

    To date, the focus in the field of sustainable building has been on new building design. However, existing residential buildings inflict great environmental burden through three causes: continuous energy consumption, regular building maintenance and replacements. This publication analyses and compa

  12. PRODUCTION CAPABILITIES EFFICIENCY PREFABRICATION ERECTION OF BUILDINGS

    Directory of Open Access Journals (Sweden)

    SOKOLOV I. A.

    2015-12-01

    Full Text Available Formulation of the problem. the largest reserves of increase of efficiency of building production concluded in the decision of problems of ensuring compliance with the technological properties of space-planning and constructive decisions of buildings organizational and technological conditions of manufacturing processes. Tendencies of development of the society determined the growth in construction, complexity of design rhenium building and makes it necessary to reduce the time of construction of buildings and reduce the cost of construction and installation works. In recent years, the architectural and compositional solutions constructed buildings are increasingly conflict with organizational, technological and technical capacity building organizations. This problem is solved by the improvement and development of new technologies of building production, the use of more modern construction machines and mechanisms. The implementation of the tasks can be solved by creating a space-planning and constructive decisions of buildings corresponding possibilities of building organizations and the creation of fundamentally new technologies. Currently, there is no single comprehensive approach allows to establish the extent to which space-constructive decisions of buildings technological possibilities of building production. Imbalance intentions and capabilities results in a significant increase in financial expenses for the construction of the building. The purpose of the article. It is necessary to propose a method of assessing the level of technological prefabrication construction of buildings, the application of which will provide an opportunity to improve the full process of erection of the building and, as a consequence, increase its efficiency by increasing the extent to which the technological properties of space-planning and constructive decisions of buildings organizational and technological conditions of manufacturing processes, pogruzki

  13. Control of Smart Building Using Advanced SCADA

    Science.gov (United States)

    Samuel, Vivin Thomas

    For complete control of the building, a proper SCADA implementation and the optimization strategy has to be build. For better communication and efficiency a proper channel between the Communication protocol and SCADA has to be designed. This paper concentrate mainly between the communication protocol, and the SCADA implementation, for a better optimization and energy savings is derived to large scale industrial buildings. The communication channel used in order to completely control the building remotely from a distant place. For an efficient result we consider the temperature values and the power ratings of the equipment so that while controlling the equipment, we are setting a threshold values for FDD technique implementation. Building management system became a vital source for any building to maintain it and for safety purpose. Smart buildings, refers to various distinct features, where the complete automation system, office building controls, data center controls. ELC's are used to communicate the load values of the building to the remote server from a far location with the help of an Ethernet communication channel. Based on the demand fluctuation and the peak voltage, the loads operate differently increasing the consumption rate thus results in the increase in the annual consumption bill. In modern days, saving energy and reducing the consumption bill is most essential for any building for a better and long operation. The equipment - monitored regularly and optimization strategy is implemented for cost reduction automation system. Thus results in the reduction of annual cost reduction and load lifetime increase.

  14. KAJIAN SUSTAINABLE DESIGN PADA SAVILL BUILDING

    Directory of Open Access Journals (Sweden)

    Oktavi Elok Hapsari

    2015-08-01

    Full Text Available Since 1980 the development of Indonesian architecture design start to leads into sustainable architectural design which as it was expected to became a solution regarding the environmental problems. The implementation of sustainable design in buildings can be applied from the buildings typologi, renewable resources on materials untill the reduction of the negative impact againts the buildings surrounding environment. As the main object for this study was 2006 The Woods Awardee, Savill Building. A literature study was conducted related to sustainable concept design and the implementation in Savill Buildings. Savill Building is a transparance walls buildings with steel and wooden as main materials on it complex curve gridshell structures. Located in a countoured site Savill Building show it assertive appearance. Due to the good landscape processing and design the Savill Building stood out and yet still shown continuity and harmony with the surrounding environment. The buildings not only has a eco-friendly public facility function, but also has the capability on attracting visitors. In the end this study is expected able expand the knowledges on sustainable design and become a design references in Indonesia architectural design.

  15. Geospatial database for heritage building conservation

    Science.gov (United States)

    Basir, W. N. F. W. A.; Setan, H.; Majid, Z.; Chong, A.

    2014-02-01

    Heritage buildings are icons from the past that exist in present time. Through heritage architecture, we can learn about economic issues and social activities of the past. Nowadays, heritage buildings are under threat from natural disaster, uncertain weather, pollution and others. In order to preserve this heritage for the future generation, recording and documenting of heritage buildings are required. With the development of information system and data collection technique, it is possible to create a 3D digital model. This 3D information plays an important role in recording and documenting heritage buildings. 3D modeling and virtual reality techniques have demonstrated the ability to visualize the real world in 3D. It can provide a better platform for communication and understanding of heritage building. Combining 3D modelling with technology of Geographic Information System (GIS) will create a database that can make various analyses about spatial data in the form of a 3D model. Objectives of this research are to determine the reliability of Terrestrial Laser Scanning (TLS) technique for data acquisition of heritage building and to develop a geospatial database for heritage building conservation purposes. The result from data acquisition will become a guideline for 3D model development. This 3D model will be exported to the GIS format in order to develop a database for heritage building conservation. In this database, requirements for heritage building conservation process are included. Through this research, a proper database for storing and documenting of the heritage building conservation data will be developed.

  16. ATLAS software configuration and build tool optimisation

    Science.gov (United States)

    Rybkin, Grigory; Atlas Collaboration

    2014-06-01

    ATLAS software code base is over 6 million lines organised in about 2000 packages. It makes use of some 100 external software packages, is developed by more than 400 developers and used by more than 2500 physicists from over 200 universities and laboratories in 6 continents. To meet the challenge of configuration and building of this software, the Configuration Management Tool (CMT) is used. CMT expects each package to describe its build targets, build and environment setup parameters, dependencies on other packages in a text file called requirements, and each project (group of packages) to describe its policies and dependencies on other projects in a text project file. Based on the effective set of configuration parameters read from the requirements files of dependent packages and project files, CMT commands build the packages, generate the environment for their use, or query the packages. The main focus was on build time performance that was optimised within several approaches: reduction of the number of reads of requirements files that are now read once per package by a CMT build command that generates cached requirements files for subsequent CMT build commands; introduction of more fine-grained build parallelism at package task level, i.e., dependent applications and libraries are compiled in parallel; code optimisation of CMT commands used for build; introduction of package level build parallelism, i. e., parallelise the build of independent packages. By default, CMT launches NUMBER-OF-PROCESSORS build commands in parallel. The other focus was on CMT commands optimisation in general that made them approximately 2 times faster. CMT can generate a cached requirements file for the environment setup command, which is especially useful for deployment on distributed file systems like AFS or CERN VMFS. The use of parallelism, caching and code optimisation significantly-by several times-reduced software build time, environment setup time, increased the efficiency of

  17. Smart Buildings: Business Case and Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    Ehrlich, Paul; Diamond, Rick

    2009-04-01

    General Services Administration (GSA) has been a pioneer in using Smart Building technologies but it has yet to achieve the full benefits of an integrated, enterprise-wide Smart Building strategy. In July 2008, GSA developed an initial briefing memorandum that identified five actions for a Smart Buildings feasibility study: (1) Identify and cluster the major building systems under consideration for a Smart Buildings initiative; (2) Identify GSA priorities for these clusters; (3) Plan for future adoption of Smart Building strategies by identifying compatible hardware; (4) Develop a framework for implementing and testing Smart Building strategies and converged networks; and (5) Document relevant GSA and industry initiatives in this arena. Based on this briefing memorandum, PBS and FAS retained consultants from Lawrence Berkeley National Laboratory, Noblis, and the Building Intelligence Group to evaluate the potential for Smart Buildings within GSA, and to develop this report. The project has included extensive interviews with GSA staff (See Appendix A), a review of existing GSA standards and documents, and an examination of relevant GSA and industry initiatives. Based on interviews with GSA staff and a review of GSA standards and documents, the project team focused on four goals for evaluating how Smart Building technology can benefit GSA: (1) Achieve Energy Efficiency Mandates--Use Smart Building technology as a tool to meet EISA 2007 and EO 13423 goals for energy efficiency. (2) Enhance Property Management--Deploy enterprise tools for improved Operations and Maintenance (O&M) performance and verification. (3) Implement Network as the Fourth Utility--Utilize a converged broadband network to support Smart Building systems and provide GSA clients with connectivity for voice, data and video. (4) Enhance Safety and Security--Harmonize Physical Access Control Systems (PACS) with Smart Building Systems.

  18. Assessment Framework of Building Facade in Optimizing Indoor Thermal Comfort of Green Building Index (GBI Certified Office Building

    Directory of Open Access Journals (Sweden)

    Abdul Tharim Asniza Hamimi

    2016-01-01

    Full Text Available During the past decade, the construction industry has seen a new trend in the development of “green” or “sustainable” construction concept around the world with vast support from prominent organization, together with the introduction of sustainable building codes. The establishment of green building certification systems worldwide is seen as one of the most efforts in the emerging green building movement. In order to support the development of the “green” and “sustainable” concept in Malaysia, Green Building Index (GBI was launched by the government on 21 May 2009 that created to promote sustainability in the built environment and raise awareness of environmental issues. However, the construction industry seems to have focused only on findings the “right mechanism” for an environmentally sustainable “final result” in order for the building to be certified as green with the lacking of continuous assessment on the building performance after the certifications. This study is purposely conducted to investigate the performance of various rated Green Building Index (GBI Non-Residential New Construction office buildings and the influence on Indoor Thermal Comfort (ITC of the selected buildings. The aim is to develop an assessment framework for optimum green building architectural façade to be used for office buildings in Malaysia as well as to analyse the occupants’ perception, satisfaction and performance in the selected Green Building Index (GBI rated office indoor environment. This research is still in its infancy; therefore the paper is focused on research aims, research scope and methodology, and expected deliverables for the proposed research.

  19. Energy modelling and capacity building

    International Nuclear Information System (INIS)

    The Planning and Economic Studies Section of the IAEA's Department of Nuclear Energy is focusing on building analytical capacity in MS for energy-environmental-economic assessments and for the elaboration of sustainable energy strategies. It offers a variety of analytical models specifically designed for use in developing countries for (i) evaluating alternative energy strategies; (ii) assessing environmental, economic and financial impacts of energy options; (iii) assessing infrastructure needs; (iv) evaluating regional development possibilities and energy trade; (v) assessing the role of nuclear power in addressing priority issues (climate change, energy security, etc.). These models can be used for analysing energy or electricity systems, and to assess possible implications of different energy, environmental or financial policies that affect the energy sector and energy systems. The models vary in complexity and data requirements, and so can be adapted to the available data, statistics and analytical needs of different countries. These models are constantly updated to reflect changes in the real world and in the concerns that drive energy system choices. They can provide thoughtfully informed choices for policy makers over a broader range of circumstances and interests. For example, they can readily reflect the workings of competitive energy and electricity markets, and cover such topics as external costs. The IAEA further offers training in the use of these models and -just as important- in the interpretation and critical evaluation of results. Training of national teams to develop national competence over the full spectrum of models, is a high priority. The IAEA maintains a broad spectrum of databanks relevant to energy, economic and environmental analysis in MS, and make these data available to analysts in MS for use in their own analytical work. The Reference Technology Data Base (RTDB) and the Reference Data Series (RDS-1) are the major vehicles by which we

  20. Analysis and Optimization of Building Energy Consumption

    Science.gov (United States)

    Chuah, Jun Wei

    Energy is one of the most important resources required by modern human society. In 2010, energy expenditures represented 10% of global gross domestic product (GDP). By 2035, global energy consumption is expected to increase by more than 50% from current levels. The increased pace of global energy consumption leads to significant environmental and socioeconomic issues: (i) carbon emissions, from the burning of fossil fuels for energy, contribute to global warming, and (ii) increased energy expenditures lead to reduced standard of living. Efficient use of energy, through energy conservation measures, is an important step toward mitigating these effects. Residential and commercial buildings represent a prime target for energy conservation, comprising 21% of global energy consumption and 40% of the total energy consumption in the United States. This thesis describes techniques for the analysis and optimization of building energy consumption. The thesis focuses on building retrofits and building energy simulation as key areas in building energy optimization and analysis. The thesis first discusses and evaluates building-level renewable energy generation as a solution toward building energy optimization. The thesis next describes a novel heating system, called localized heating. Under localized heating, building occupants are heated individually by directed radiant heaters, resulting in a considerably reduced heated space and significant heating energy savings. To support localized heating, a minimally-intrusive indoor occupant positioning system is described. The thesis then discusses occupant-level sensing (OLS) as the next frontier in building energy optimization. OLS captures the exact environmental conditions faced by each building occupant, using sensors that are carried by all building occupants. The information provided by OLS enables fine-grained optimization for unprecedented levels of energy efficiency and occupant comfort. The thesis also describes a retrofit

  1. Building 894 hazards assessment document

    International Nuclear Information System (INIS)

    The Department of Energy Order 5500.3A requires facility-specific hazards assessments be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with Building 894. The entire inventory was subjected to the screening criteria for potential airborne impact to onsite and offsite individuals out of which 9 chemicals were kept for further evaluation. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distance at which a postulated facility event will produce consequences exceeding the Early Severe Health Effects threshold is 130 meters. The highest emergency classification is a General Emergency. The Emergency Planning Zone is a nominal 130 meter area that conforms to DOE boundaries and physical/jurisdictional boundaries such as fence lines and streets

  2. Energy savings in Polish buildings

    Energy Technology Data Exchange (ETDEWEB)

    Markel, L.C.; Gula, A.; Reeves, G.

    1995-12-31

    A demonstration of low-cost insulation and weatherization techniques was a part of phase 1 of the Krakow Clean Fossil Fuels and Energy Efficient Project. The objectives were to identify a cost-effective set of measures to reduce energy used for space heating, determine how much energy could be saved, and foster widespread implementation of those measures. The demonstration project focused on 4 11-story buildings in a Krakow housing cooperative. Energy savings of over 20% were obtained. Most important, the procedures and materials implemented in the demonstration project have been adapted to Polish conditions and applied to other housing cooperatives, schools, and hospitals. Additional projects are being planned, in Krakow and other cities, under the direction of FEWE-Krakow, the Polish Energie Cities Network, and Biuro Rozwoju Krakowa.

  3. Diagnosing the tight building syndrome.

    Science.gov (United States)

    Rogers, S A

    1987-12-01

    Formaldehyde is but one of many chemicals capable of causing the tight building syndrome or environmentally induced illness (EI). The spectrum of symptoms it may induce includes attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness, arthralgia, unwarranted depression, dysphonia, exhaustion, inability to think clearly, arrhythmia or muscle spasms. The nonspecificity of such symptoms can baffle physicians from many specialties. Presented herein is a simple office method for demonstrating that formaldehyde is among the etiologic agents triggering these symptoms. The very symptoms that patients complain of can be provoked within minutes, and subsequently abolished, with an intradermal injection of the appropriate strength of formaldehyde. This injection aids in convincing the patient of the cause of the symptoms so he can initiate measures to bring his disease under control.

  4. Green Construction in Building Renovation

    Science.gov (United States)

    Ksit, Barbara; Majcherek, Michał

    2016-06-01

    Modern materials and construction solutions draw more and more attention to ecology and building certification. Among the criteria appearing in revitalization, an important element is bringing plants back into heavily urbanized areas. In its natural form, this is not possible to carry out everywhere, often requiring large amounts of space. Nowadays, however, there are a number of green roofs and green wall systems, allowing "greener" construction without making significant changes in the urban environment. The article includes a presentation and analysis of selected solutions of biological surfaces known as green roofs and green walls, specifying various solutions and their most important features. The case study focuses primarily on material and design solutions, as well as the potential benefits, risks and limitations in their use. Plants structures on the surfaces of vertical and horizontal partitions continue to be a very interesting alternative to take into account when applying for grants, such as LEED or BREEAM certificates.

  5. Building Better Nurse Scheduling Algorithms

    CERN Document Server

    Aickelin, Uwe

    2008-01-01

    The aim of this research is twofold: Firstly, to model and solve a complex nurse scheduling problem with an integer programming formulation and evolutionary algorithms. Secondly, to detail a novel statistical method of comparing and hence building better scheduling algorithms by identifying successful algorithm modifications. The comparison method captures the results of algorithms in a single figure that can then be compared using traditional statistical techniques. Thus, the proposed method of comparing algorithms is an objective procedure designed to assist in the process of improving an algorithm. This is achieved even when some results are non-numeric or missing due to infeasibility. The final algorithm outperforms all previous evolutionary algorithms, which relied on human expertise for modification.

  6. Designing Smart Knowledge Building Communities

    Directory of Open Access Journals (Sweden)

    Ambar Murillo Montes de Oca

    2014-11-01

    Full Text Available Knowledge building communities (KBCs are environments where learning is continually occurring as a social process, and the collective knowledge base is gradually being expanded upon. Knowledge accessible to all members is produced in collaborative discourse, along with the development and the use of conceptual artifacts. This theoretical contribution discusses the possibilities to foster and design KBCs in a “smart” manner so that they can be connected to formal learning. Firstly, the paper identifies the characteristics of “smartness” for the context of KBCs: participants (individuals and groups, collaboration and convergence, as well as technology that may provide enabling and monitoring tools. Secondly, tools are suggested to foster and monitor the development and the use of collaborative discourse and conceptual artifacts. Thirdly, recommendations for the design of smart KBCs are provided. Finally, a research agenda is proposed based on the previous discussions.

  7. Waste Handling Building Conceptual Study

    International Nuclear Information System (INIS)

    The objective of the ''Waste Handling Building Conceptual Study'' is to develop proposed design requirements for the repository Waste Handling System in sufficient detail to allow the surface facility design to proceed to the License Application effort if the proposed requirements are approved by DOE. Proposed requirements were developed to further refine waste handling facility performance characteristics and design constraints with an emphasis on supporting modular construction, minimizing fuel inventory, and optimizing facility maintainability and dry handling operations. To meet this objective, this study attempts to provide an alternative design to the Site Recommendation design that is flexible, simple, reliable, and can be constructed in phases. The design concept will be input to the ''Modular Design/Construction and Operation Options Report'', which will address the overall program objectives and direction, including options and issues associated with transportation, the subsurface facility, and Total System Life Cycle Cost. This study (herein) is limited to the Waste Handling System and associated fuel staging system

  8. Building a strategic security organisation.

    Science.gov (United States)

    Howard, Mike

    2016-01-01

    In everyone's day-to-day jobs there is constant need to deal with current and newly detected matters. This is now a world of immediacy, driven by the cadence of the business and its needs. These concerns should not be ignored, as failing to deal with these issues would not bode well for the future. It is essential that the gears are kept spinning. The challenge for any security organisation is to identify its short-term tactical requirements, while developing longer-term strategic needs. Once done, the differences can be accounted for and strides can be made toward a desired future state. This paper highlights several steps that the author and his team have taken in their own journey. There is no magic answer, each organisation will have its own unique challenges. Nevertheless, some of the approaches to building a strategic security organisation described in this paper are applicable to all organisations, irrespective of their size. PMID:27318284

  9. Tools for building virtual laboratories

    International Nuclear Information System (INIS)

    There is increasing interest in making unique research facilities facilities accessible on the Internet. Computer systems, scientific databases and experimental apparatus can be used by international collaborations of scientists using high-speed networks and advanced software tools to support collaboration. We are building tools including video conferencing and electronic white boards that are being used to create examples of virtual laboratories. This paper describes two pilot projects which provide testbeds for the tools. The first is a virtual laboratory project providing remote access to LBNL's Advanced Light Source. The second is the Multidimensional Applications and Gigabit internet work Consortium (MAGIC) testbed which has been established to develop a very high-speed, wide-are network to deliver realtime data at gigabit-per-second rates. (author)

  10. Diagnosing the tight building syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, S.A.

    1987-12-01

    Formaldehyde is but one of many chemicals capable of causing the tight building syndrome or environmentally induced illness (EI). The spectrum of symptoms it may induce includes attacks of headache, flushing, laryngitis, dizziness, nausea, extreme weakness, arthralgia, unwarranted depression, dysphonia, exhaustion, inability to think clearly, arrhythmia or muscle spasms. The nonspecificity of such symptoms can baffle physicians from many specialties. Presented herein is a simple office method for demonstrating that formaldehyde is among the etiologic agents triggering these symptoms. The very symptoms that patients complain of can be provoked within minutes, and subsequently abolished, with an intradermal injection of the appropriate strength of formaldehyde. This injection aids in convincing the patient of the cause of the symptoms so he can initiate measure to bring his disease under control.

  11. Building Information Modeling Comprehensive Overview

    Directory of Open Access Journals (Sweden)

    Sergey Kalinichuk

    2015-07-01

    Full Text Available The article is addressed to provide a comprehensive review on recently accelerated development of the Information Technology within project market such as industrial, engineering, procurement and construction. Author’s aim is to cover the last decades of the growth of the Information and Communication Technology in construction industry in particular Building Information Modeling and testifies that the problem of a choice of the effective project realization method not only has not lost its urgency, but has also transformed into one of the major condition of the intensive technology development. All of it has created a great impulse on shortening the project duration and has led to the development of various schedule compression techniques what becomes a focus of modern construction.

  12. Sustainable building and local resources

    Directory of Open Access Journals (Sweden)

    Maria Cristina Forlani

    2014-05-01

    Full Text Available The research comes from the deepest reasons of the crisis, in order to recognize in such reasons themselves the direction to come out, the new needs and the new challenges. The local resources (material and immaterial were reconsidered as patrimony, precious but limited, of each specific area to trace out a path of supportability able to rebuild new relations between project/production and environmental culture. The industrial production becomes a driving force for the economic renewal through an iterative cycle between research/science and economics aiming to smart building, meant as practice in evolution. This practise is careful to the local, environmental, cultural and economic situation, whose parameters are identity, energy, environment, mobility and economics that give back different scale answers.

  13. Automatic Building Information Model Query Generation

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Yufei; Yu, Nan; Ming, Jiang; Lee, Sanghoon; DeGraw, Jason; Yen, John; Messner, John I.; Wu, Dinghao

    2015-12-01

    Energy efficient building design and construction calls for extensive collaboration between different subfields of the Architecture, Engineering and Construction (AEC) community. Performing building design and construction engineering raises challenges on data integration and software interoperability. Using Building Information Modeling (BIM) data hub to host and integrate building models is a promising solution to address those challenges, which can ease building design information management. However, the partial model query mechanism of current BIM data hub collaboration model has several limitations, which prevents designers and engineers to take advantage of BIM. To address this problem, we propose a general and effective approach to generate query code based on a Model View Definition (MVD). This approach is demonstrated through a software prototype called QueryGenerator. By demonstrating a case study using multi-zone air flow analysis, we show how our approach and tool can help domain experts to use BIM to drive building design with less labour and lower overhead cost.

  14. DOE Commercial Building Benchmark Models: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Torcelini, P.; Deru, M.; Griffith, B.; Benne, K.; Halverson, M.; Winiarski, D.; Crawley, D. B.

    2008-07-01

    To provide a consistent baseline of comparison and save time conducting such simulations, the U.S. Department of Energy (DOE) has developed a set of standard benchmark building models. This paper will provide an executive summary overview of these benchmark buildings, and how they can save building analysts valuable time. Fully documented and implemented to use with the EnergyPlus energy simulation program, the benchmark models are publicly available and new versions will be created to maintain compatibility with new releases of EnergyPlus. The benchmark buildings will form the basis for research on specific building technologies, energy code development, appliance standards, and measurement of progress toward DOE energy goals. Having a common starting point allows us to better share and compare research results and move forward to make more energy efficient buildings.

  15. Handbook of energy use for building construction

    Energy Technology Data Exchange (ETDEWEB)

    Stein, R.G.; Stein, C.; Buckley, M.; Green, M.

    1980-03-01

    The construction industry accounts for over 11.14% of the total energy consumed in the US annually. This represents the equivalent energy value of 1 1/4 billion barrels of oil. Within the construction industry, new building construction accounts for 5.19% of national annual energy consumption. The remaining 5.95% is distributed among new nonbuilding construction (highways, ralroads, dams, bridges, etc.), building maintenance construction, and nonbuilding maintenance construction. The handbook focuses on new building construction; however, some information for the other parts of the construction industry is also included. The handbook provides building designers with information to determine the energy required for buildings construction and evaluates the energy required for alternative materials, assemblies, and methods. The handbook is also applicable to large-scale planning and policy determination in that it provides the means to estimate the energy required to carry out major building programs.

  16. Utilization of structural steel in buildings.

    Science.gov (United States)

    Moynihan, Muiris C; Allwood, Julian M

    2014-08-01

    Over one-quarter of steel produced annually is used in the construction of buildings. Making this steel causes carbon dioxide emissions, which climate change experts recommend be reduced by half in the next 37 years. One option to achieve this is to design and build more efficiently, still delivering the same service from buildings but using less steel to do so. To estimate how much steel could be saved from this option, 23 steel-framed building designs are studied, sourced from leading UK engineering firms. The utilization of each beam is found and buildings are analysed to find patterns. The results for over 10 000 beams show that average utilization is below 50% of their capacity. The primary reason for this low value is 'rationalization'-providing extra material to reduce labour costs. By designing for minimum material rather than minimum cost, steel use in buildings could be drastically reduced, leading to an equivalent reduction in 'embodied' carbon emissions.

  17. MOISTURE-BUFFERING CHARACTERISTICS OF BUILDING MATERIALS

    Directory of Open Access Journals (Sweden)

    Young Cheol Choi

    2016-05-01

    Full Text Available The humidity level of indoor air is an important factor influencing the air quality and energy consumption of buildings, as well as the durability of building components. Indoor humidity levels depend on several factors, such as moisture sources, air flow, and the adsorption/desorption properties of materials. The moisture-buffering characteristics of building materials that are in contact with indoor air may help moderate the variations of indoor humidity, especially in the summer and winter. In this study, the moisture adsorption/desorption properties of building materials were investigated experimentally and numerically. These properties can be used to characterize the ability of building materials to exchange moisture with the indoor environment. This study indicates that a building material surface resistivity was the main factor creating variations of moisture buffering.

  18. Commercial Buildings Energy Performance within Context

    DEFF Research Database (Denmark)

    Lazarova-Molnar, Sanja; Kjærgaard, Mikkel Baun; Shaker, Hamid Reza;

    2015-01-01

    Existing commercial buildings represent a challenge in the energy efficiency domain. Energy efficiency of a building, very often equalized to a building’s performance should not be observed as a standalone issue. For commercial buildings, energy efficiency needs to be observed and assessed within...... the context of performance of resident businesses. We examine both business performance and energy performance and how they relate to one another to conclude that building occupants, who are also employees, hold the key to optimizing both metrics in one of the most cost-efficient ways. Finally, the goal...... of our contribution is twofold: 1) to re-scope the concept of building performance to and show the importance to consider, hand- in-hand, both energy performance and performance of resident businesses, and 2) re-state the importance of the potential that lies in the active involvement of building...

  19. Technologies used for research in intelligent buildings

    Science.gov (United States)

    Kolková, Zuzana; Matušov, Jozef; Mokrý, Marián

    2016-06-01

    The efficient use of primary energy and their impact on the environment is influenced in several ways. The key is implementation of modern low-energy structures and technologies in building construction, the use of high energy sources such fossil fuels and renewable energy, the optimal management, appropriate choice of sources of heat and cold. Optimal control of energy consumption in buildings and premises may be an appropriate choice of sources of heat and cold. Energy sources should be in addition to high efficiency and meet the requirement of minimizing the emission load environment. All this can be achieved by implementing the construction of intelligent buildings. University of Žilina in the project Research Centre of the University of Žilina decided to build such building. Use of this building will be addressing many research activities at the university with links to industry.

  20. Automatic Detection of Buildings and Changes in Buildings for Updating of Maps

    Directory of Open Access Journals (Sweden)

    Harri Kaartinen

    2010-04-01

    Full Text Available There is currently high interest in developing automated methods to assist the updating of map databases. This study presents methods for automatic detection of buildings and changes in buildings from airborne laser scanner and digital aerial image data and shows the potential usefulness of the methods with thorough experiments in a 5 km2 suburban study area. 96% of buildings larger than 60 m2 were correctly detected in the building detection. The completeness and correctness of the change detection for buildings larger than 60 m2 were about 85% (including five classes. Most of the errors occurred in small or otherwise problematic buildings.

  1. Building Maintenance Management System for Heritage Museum

    OpenAIRE

    Md Azree Othuman Mydin; Siti Hajar Ismail; Norhidayah Md Ulang

    2012-01-01

    An investment in the building maintenance aspect is massive throughout the world. In most of the countries, it signifies approximately 50% of the entire revenue of the construction industry. The value of buildings depends on the eminence of the maintenance invested in them. Maintenance management engages obtaining utmost advantage from the investment made on the maintenance activities. At the moment, maintenance in buildings in Malaysia is on the increase in spite of size, ...

  2. Assessing prefabrication processes in house building systems

    OpenAIRE

    SCHEFFER, ZOLTAN

    2013-01-01

    This thesis surveys the current building energy regulations in the European Union, Hungary and Spain. Also, surveys the history of the use of prefabricated methods in house building. Then, applies calculations on a example of prefabricated building, defined by the national rules, and makes an analysis of them. The objective is to provide suggestions for improving the thermal behavior of the structure with the aim to improve its energy efficiency, using energy and environment conscious solutio...

  3. Bitstream - Capacity Building for Innovation : Final report

    OpenAIRE

    Söderström, Mikael; Hedestig, Ulf; Fallmyr, Terje; Ellingsen, Kjell; Hegerholm, Hallstein; Klæboe, Geir-Tore

    2014-01-01

    The main objective of the Bitstream project was to create a transnational platform for capacity building and exchange of experiences in the area of innovative business development. This includes capacity building for staff in the public sector in Norway and Sweden. The project deliverables has been to accomplish A virtual and physical transnational platform for capacity building that includes a cross-border exchange of experiences, research and developments in innovative business development....

  4. Adaptive fuzzy logic control for solar buildings

    OpenAIRE

    El-Deen, M. M. G. Naser

    2002-01-01

    Significant progress has been made on maximising passive solar heating loads through the careful selection of glazing, orientation and internal mass within building spaces. Control of space heating in buildings of this type has become a complex problem. Additionally, and in common with most building control applications, there is a need to develop control solutions that permit simple and transparent set up and commissioning procedures. This work concerns the development and testing of an adap...

  5. Building America Research-to-Market Plan

    Energy Technology Data Exchange (ETDEWEB)

    Werling, Eric [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2015-11-01

    This report presents the Building America Research-to-Market Plan (Plan), including the integrated Building America Technology-to-Market Roadmaps (Roadmaps) that will guide Building America’s research, development, and deployment (RD&D) activities over the coming years. The Plan and Roadmaps will be updated as necessary to adapt to research findings and evolving stakeholder needs, and they will reflect input from DOE and stakeholders.

  6. Design of an energy conservation building

    Science.gov (United States)

    Jensen, R. N.

    1981-01-01

    The concepts in designing and predicting energy consumption in a low energy use building are summarized. The building will use less than 30,000 Btu/sq.ft./yr. of boarder energy. The building's primary energy conservation features include heavy concrete walls with external insulation, a highly insulated ceiling, and large amounts of glass for natural lighting. A solar collector air system is integrated into the south wall. Calculations for energy conservation features were performed using NASA's NECAP Energy Program.

  7. Recent developments in building diagnosis techniques

    CERN Document Server

    2016-01-01

    This book presents a collection of recent research on building diagnosis techniques related to construction pathology, hygrothermal behavior and durability, and diagnostic techniques. It highlights recent advances and new developments in the field of building physics, building anomalies in materials and components, new techniques for improved energy efficiency analysis, and diagnosis techniques such as infrared thermography. This book will be of interest to a wide readership of professionals, scientists, students, practitioners, and lecturers.

  8. Sustainability assessment and standardisation : steel buildings

    OpenAIRE

    Andrade, Joana B.; Bragança, L.

    2012-01-01

    This paper aims at evaluating in what extent are the existing sustainability assessment methodologies capable of truly reward the benefits of steel-intensive buildings in comparison with other building construction solutions. This evaluation consists in describing the more common sustainability assessment methodologies from the steel construction point of view and in comparing existing assessments to steel buildings. The pros and cons of each will also be pointed out, in order ...

  9. Influence of structural design on building costs

    OpenAIRE

    Sattler Cantons, Fernando

    2016-01-01

    This paper deals with the analysis and design of two buildings for two different uses. The first one is intended for residential use, while the second is designed for office usage. These buildings will be located in the city of Trondheim, Norway. The main objective of this document is to determine how the different structural designs for the same building affect in the final costs of the structure, taking into account different materials. The materials considered during the design and anal...

  10. WASTE TREATMENT BUILDING SYSTEM DESCRIPTION DOCUMENT

    Energy Technology Data Exchange (ETDEWEB)

    F. Habashi

    2000-06-22

    The Waste Treatment Building System provides the space, layout, structures, and embedded subsystems that support the processing of low-level liquid and solid radioactive waste generated within the Monitored Geologic Repository (MGR). The activities conducted in the Waste Treatment Building include sorting, volume reduction, and packaging of dry waste, and collecting, processing, solidification, and packaging of liquid waste. The Waste Treatment Building System is located on the surface within the protected area of the MGR. The Waste Treatment Building System helps maintain a suitable environment for the waste processing and protects the systems within the Waste Treatment Building (WTB) from most of the natural and induced environments. The WTB also confines contaminants and provides radiological protection to personnel. In addition to the waste processing operations, the Waste Treatment Building System provides space and layout for staging of packaged waste for shipment, industrial and radiological safety systems, control and monitoring of operations, safeguards and security systems, and fire protection, ventilation and utilities systems. The Waste Treatment Building System also provides the required space and layout for maintenance activities, tool storage, and administrative facilities. The Waste Treatment Building System integrates waste processing systems within its protective structure to support the throughput rates established for the MGR. The Waste Treatment Building System also provides shielding, layout, and other design features to help limit personnel radiation exposures to levels which are as low as is reasonably achievable (ALARA). The Waste Treatment Building System interfaces with the Site Generated Radiological Waste Handling System, and with other MGR systems that support the waste processing operations. The Waste Treatment Building System interfaces with the General Site Transportation System, Site Communications System, Site Water System, MGR

  11. Comparison of energy balances in public buildings

    OpenAIRE

    Avguštin, Nejc

    2015-01-01

    The thesis deals with a comparative analysis of energy balance of public buildings before and after energy renovation. Most of the energy renovations of public buildings in Slovenia between 2010 and 2015 was co-financed by the Cohesion Fund of the European Union. The analysis is based on the calculations of energy balances of the buildings before and after renovation. The calculations were carried out by designers prior to submitting the project application for subsidy. We had ...

  12. Preindustrial versus postindustrial Architecture and Building Techniques

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2014-01-01

    and environmental conditions give perspectives and guide a knowledge based evolution of basic experience into an industrialized building process. Methodology used are comparative analysis on the specific 2 types: 2 long houses build related to the ideals of the preindustrial and the postindustrial period will point...... will characterize a future building stock and to which level buildings are expected to operate in relation to the actual demands of zero energy performance and better indoor living comfort. In that way we will be aware of the great evolution in our ways of managing the physical frame of our daily life....

  13. Building Technologies Research and Integration Center (BTRIC)

    Data.gov (United States)

    Federal Laboratory Consortium — The Building Technologies Research and Integration Center (BTRIC), in the Energy and Transportation Science Division (ETSD) of Oak Ridge National Laboratory (ORNL),...

  14. Advanced Energy Retrofit Guide Office Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Guopeng; Liu, Bing; Wang, Weimin; Zhang, Jian; Athalye, Rahul A.; Moser, Dave; Crowe, Eliot; Bengtson, Nick; Effinger, Mark; Webster, Lia; Hatten, Mike

    2011-09-27

    The Advanced Energy Retrofit Guide for Office Buildings is a component of the Department of Energy’s Advanced Energy Retrofit Guides for Existing Buildings series. The aim of the guides is to facilitate a rapid escalation in the number of energy efficiency projects in existing buildings and to enhance the quality and depth of those projects. By presenting general project planning guidance as well as financial payback metrics for the most common energy efficiency measures, these guides provide a practical roadmap to effectively planning and implementing performance improvements for existing buildings.

  15. Advanced Energy Retrofit Guide Retail Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Guopeng; Liu, Bing; Zhang, Jian; Wang, Weimin; Athalye, Rahul A.; Moser, Dave; Crowe, Eliot; Bengtson, Nick; Effinger, Mark; Webster, Lia; Hatten, Mike

    2011-09-19

    The Advanced Energy Retrofit Guide for Retail Buildings is a component of the Department of Energy’s Advanced Energy Retrofit Guides for Existing Buildings series. The aim of the guides is to facilitate a rapid escalation in the number of energy efficiency projects in existing buildings and to enhance the quality and depth of those projects. By presenting general project planning guidance as well as financial payback metrics for the most common energy efficiency measures, these guides provide a practical roadmap to effectively planning and implementing performance improvements for existing buildings.

  16. Building a PC in easy steps

    CERN Document Server

    Yarnold, Stuart

    2011-01-01

    Written for those who want more than what the standard pre-built PCs offer. Pre-built systems are often, a compromise between what the manufacturers want to sell you and what you want to buy. One solution is to build it yourself. Acquiring a copy of Building a PC in easy steps is the first step in the right direction to build a PC. Written in concise and easy-to-understand style, this book will take you by the hand and walk you through all the stages of building and setting up a computer: Buying the parts and avoiding sales scams; mastering and installing each component (CPU, memory, video, et

  17. Zero energy buildings and mismatch compensation factors

    DEFF Research Database (Denmark)

    Lund, Henrik; Marszal, Anna Joanna; Heiselberg, Per

    2011-01-01

    individual buildings and an element of economy of scale. For these three reasons mismatches should be dealt with at the aggregated level and not at the individual level of each building. Instead, this paper suggests to compensate the mismatch of a building by increasing (or decreasing) the capacity...... of the energy production unit. Based on historical data for the electricity supply area in western Denmark, this paper makes a first attempt to quantify mismatch compensation factors. The results indicate that such compensation factors are a little below one for buildings with photovoltaics (PV) and a little...

  18. THE ECONOMIC EVALUATION OF FOREST ROAD BUILDING

    OpenAIRE

    Muška, Aina; Bičevskis, Matīss

    2010-01-01

    Forest road density in Latvia is insufficient, although the Joint Stock Company ‘‘Latvijas valsts meži” (“Latvian State Forestry”) performs active forest road building. The hypothesis of the research is that the resources invested in a forest road building pay off during its use. The goal of the research is to study the economic benefit from forest road building. The authors’ research showed that the total costs of forest road building and use could result in Ls 246,779 over 40 years or Ls 6,...

  19. New build: Materials, techniques, skills and innovation

    International Nuclear Information System (INIS)

    The transition to secure, sustainable, low-energy systems will have a significant effect on the way in which we design and construct new buildings. In turn, the new buildings that are constructed will play a critical role in delivering the better performance that would be expected from such a transition. Buildings account for about half of UK carbon dioxide (CO2) production. So it is urgent to ensure that energy is used efficiently in existing buildings and that new building stock is better able to cope with whatever the future holds. Most energy used in buildings goes towards heating, lighting and cooling, but a growing percentage is consumed by domestic appliances, computers and other electrical equipment. Actual energy consumption is the product of a number of factors, including individual behaviours and expectations, the energy efficiency of appliances and the building envelope. This review focuses on the third of these, the building itself, and its design and construction. It discusses the issues faced by the construction industry today, suggesting that major changes are needed relating to materials, techniques, skills and innovation. It moves on to consider future advances to 2050 and beyond, including developments in ICT, novel materials, skills and automation, servitisation (the trend for manufacturers to offer lifetime services rather than simple products), performance measurement and reporting, and resilience. We present a vision of the new build construction industry in 2050 and recommendations for policy makers, industry organisations and construction companies

  20. PART BUILDING ORIENTATION OPTIMIZATION METHOD IN STEREOLITHOGRAPHY

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Aiming at the part quality and building time problems in stereolithography (SL) caused by unreasonable building orientation, a part building orientation decision method in SL rapid prototyping (RP) is carried out. Bringing into full consideration of the deformation, stair-stepping effect, overcure effect and building time related to the part fabrication orientation, and using evaluation function method, a multi-objective optimization model for the building orientation is defined. According to the difference in the angles between normal vectors of triangular facets in standard triangulation language (STL) model and z axis, the expressions of deformation area, stair-stepping area, overcure area are established. According to the characteristics in SL process, part building time is divided into four sections, that is, hatching scanning time, outline scanning time, support building time and layer waiting time. Expressions of each building time section are given. Considering the features of this optimization model, genetic algorithm (GA) is used to derive the optimization objective, related software is developed and optimization results are tested through experiments. Application shows that this method can effectively solve the quality and efficiency troubles caused by unreasonable part building orientation, an automatic orientation-determining program is developed and verified through test.