Sample records for buddies bring biology

  1. Buddy Board

    DEFF Research Database (Denmark)

    Enggaard, Helle; Moselund, Lene


    udviklingspotentiale. Rammer og baggrund for projektet er beskrevet i bilag 1. Dette resumé er skrevet på baggrund af kvalitative data, som er indsamlet i forbindelse med afprøvning af BuddyBoard på Havly (Sæby Ældrecenter) i perioden november 2014 – marts 2015. Hovedpunkterne i resuméet er en beskrivelse teknologiens...

  2. DNA Barcoding Investigations Bring Biology to Life (United States)

    Musante, Susan


    This article describes how DNA barcoding investigations bring biology to life. Biologists recognize the power of DNA barcoding not just to teach biology through connections to the real world but also to immerse students in the exciting process of science. As an investigator in the Program for the Human Environment at Rockefeller University in New…

  3. "Bud, Not Buddy." (United States)

    Brodie, Carolyn S.


    Discusses the award-winning book "Bud, Not Buddy" written by Christopher Paul Curtis. Lists different versions of the book; suggests learning activities; lists sources for biographical information and interviews with Curtis, teacher guides, professional articles, and other Depression era novels; and provides a citation for the author's…

  4. BuddyPress theme development

    CERN Document Server

    Lister, Tammie


    This book is a hands-on tutorial guide to using BuddyPress.This book is great for designers and developers who are looking to learn how to develop BuddyPress themes. It's assumed that the reader has some understanding of Wordpress and is familiar with CSS and HTML.

  5. Mathematical models in biology bringing mathematics to life

    CERN Document Server

    Ferraro, Maria; Guarracino, Mario


    This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy.  The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content...

  6. Bringing RNA into View: RNA and Its Roles in Biology. (United States)

    Atkins, John F.; Ellington, Andrew; Friedman, B. Ellen; Gesteland, Raymond F.; Noller, Harry F.; Pasquale, Stephen M.; Storey, Richard D.; Uhlenbeck, Olke C.; Weiner, Alan M.

    This guide presents a module for college students on ribonucleic acid (RNA) and its role in biology. The module aims to integrate the latest research and its findings into college-level biology and provide an opportunity for students to understand biological processes. Four activities are presented: (1) "RNA Structure: Tapes to Shapes"; (2) "RNA…

  7. Animal Experimentation: Bringing Ethical Issues into Biology Teaching. (United States)

    Van Rooy, Wilhelmina


    There are many possibilities for the use of controversial issues such as animal experimentation in biology classrooms. Outlines a series of three lessons that asked senior biology students to consider the issue of animal experimentation from three perspectives. (Author/LM)

  8. Dynamics of mathematical models in biology bringing mathematics to life

    CERN Document Server

    Zazzu, Valeria; Guarracino, Mario


    This volume focuses on contributions from both the mathematics and life science community surrounding the concepts of time and dynamicity of nature, two significant elements which are often overlooked in modeling process to avoid exponential computations. The book is divided into three distinct parts: dynamics of genomes and genetic variation, dynamics of motifs, and dynamics of biological networks. Chapters included in dynamics of genomes and genetic variation analyze the molecular mechanisms and evolutionary processes that shape the structure and function of genomes and those that govern genome dynamics. The dynamics of motifs portion of the volume provides an overview of current methods for motif searching in DNA, RNA and proteins, a key process to discover emergent properties of cells, tissues, and organisms. The part devoted to the dynamics of biological networks covers networks aptly discusses networks in complex biological functions and activities that interpret processes in cells. Moreover, chapters i...

  9. The death of buddy diving? (United States)

    Cooper, P David


    Dear Editor, By focussing on the details of the Watson case, I believe Bryan Walpole has missed the thrust of my earlier letter. I agree this was a complex case, which is why I deliberately avoided the murky specifics in order to consider the 'big-picture' ramifications of the judgement. My concerns relate to the potential consequences of the unintended interplay between unrelated developments in the medical and legal arenas. Taken together, I believe these developments threaten the very institution of buddy diving. I have been unable to verify Dr Walpole's claim that the statute under which Mr Watson was convicted has not been used previously in a criminal trial. I must, however, refute his assertion that this legislation is some sort of idiosyncratic historical hangover or legal curiosity unique to Queensland. Although the original legislation pre-dates Australian federation, this statute has survived intact through 110 years of reviews and amendments to the Queensland Criminal Code. The application of this 19th century law to the Watson case now provides a direct, post-federation, 21st century relevance. Nor is Queensland alone in having such a statute on its books. Section 151 of the Criminal Code Act in Dr Walpole's home state of Tasmania states "When a person undertakes to do any act, the omission to do which is or may be dangerous to human life or health, it is his duty to do that act." Similar statutes can also be found in the legislation of other Australian states and as far afield as New Zealand and Canada. The phrasing of the relevant sections is, in many cases, almost identical to Queensland's, reflecting the common judicial heritage of these places. Even if this ruling's reach extended no further than the Queensland border its ramifications would be immense. Tourism statistics reveal that over 1.2 million visitors perform nearly 3.5 million dives/snorkels in Queensland each year. An estimated 93% of international divers visiting Australia stopover in

  10. Novel use of the "buddy"wire.

    LENUS (Irish Health Repository)

    O'Hare, A


    Summary: During interventional procedures the tortuosity of the vasculature hampers catheter stability. The buddy wire may be used to aid and maintain vascular access.We describe a case of acute subarachnoid haemorrhage secondary to dissecting aneurysm of the vertebral artery.We discuss the value of the buddy wire during balloon occlusion of the vertebral artery not as it is typically used, but to actually prevent the balloon repeatedly entering the posterior inferior cerebellar artery during the procedure.

  11. Beyond the Cell: Using Multiscalar Topics to Bring Interdisciplinarity into Undergraduate Cellular Biology Courses (United States)

    Weber, Carolyn F.


    Western science has grown increasingly reductionistic and, in parallel, the undergraduate life sciences curriculum has become disciplinarily fragmented. While reductionistic approaches have led to landmark discoveries, many of the most exciting scientific advances in the late 20th century have occurred at disciplinary interfaces; work at these interfaces is necessary to manage the world’s looming problems, particularly those that are rooted in cellular-level processes but have ecosystem- and even global-scale ramifications (e.g., nonsustainable agriculture, emerging infectious diseases). Managing such problems requires comprehending whole scenarios and their emergent properties as sums of their multiple facets and complex interrelationships, which usually integrate several disciplines across multiple scales (e.g., time, organization, space). This essay discusses bringing interdisciplinarity into undergraduate cellular biology courses through the use of multiscalar topics. Discussing how cellular-level processes impact large-scale phenomena makes them relevant to everyday life and unites diverse disciplines (e.g., sociology, cell biology, physics) as facets of a single system or problem, emphasizing their connections to core concepts in biology. I provide specific examples of multiscalar topics and discuss preliminary evidence that using such topics may increase students’ understanding of the cell’s position within an ecosystem and how cellular biology interfaces with other disciplines. PMID:27146162

  12. Fast Allocation and Deallocation with an Improved Buddy System

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Demaine, Erik D.; Munro, J. Ian


    We propose several modifications to the binary buddy system for managing dynamic allocation of memory blocks whose sizes are powers of two. The standard buddy system allocates and deallocates blocks in Theta(lg n) time in the worst case (and on an amortized basis), where n is the size of the memo...

  13. An Antique Microscope Slide Brings the Thrill of Discovery into a Contemporary Biology Classroom (United States)

    Reiser, Frank


    The discovery of a Victorian-era microscope slide titled "Grouped Flower Seeds" began an investigation into the scientific and historical background of the antique slide to develop its usefulness as a multidisciplinary tool for PowerPoint presentations usable in contemporary biology classrooms, particularly large-enrollment sections. The resultant…

  14. Classmate Peer-Coaching: "A Study Buddy Support Scheme" (United States)

    Thalluri, Jyothi; O'Flaherty, Jackie A.; Shepherd, Paul L.


    This study had two aims: firstly, to determine whether participation in a peer support scheme called Study Buddy Support (SBS) improves pass rates of "at risk" students, and secondly, to examine the advantages of this model over hierarchical models where senior students tutor junior years. Bachelor of Nursing and Midwifery students in a…

  15. Reading for Real: Our Year with Reading Buddies (United States)

    Ross, Patricia


    When Patricia Ross' high school students at the Phoenix Day School for the Deaf buddied up with elementary school students to improve their reading skills, amazing things happened. As they read to them, Ross' students, who were part of the 2012-2013 Integrated Language Arts and Social Studies program, increased their reading scores and forged…

  16. User Validation of an Empathic Virtual Buddy against Cyberbullying

    NARCIS (Netherlands)

    Van der Zwaan, J.M.; Geraerts, E.; Dignum, V.; Jonker, C.M.


    People are able to comfort others by talking about their problems. In our research, we are exploring whether computers can provide social support in a similar manner. Recently, we proposed a design for an empathic virtual buddy that supports victims of cyberbullying. To validate our approach in

  17. Recognizing Students' Multiple Intelligences in Cross-Age Buddy Journals. (United States)

    Glasgow, Jacqueline N.


    Describes a project in which students in a college survey class on young adult literature were paired with students in a high school English class in a "buddy journal" project. Shows examples of this writing and of the assignments which used Howard Gardner's concept of multiple intelligences to offer students multiple paths for responding to…

  18. The Biological Contributions to Gender Identity and Gender Diversity: Bringing Data to the Table. (United States)

    Polderman, Tinca J C; Kreukels, Baudewijntje P C; Irwig, Michael S; Beach, Lauren; Chan, Yee-Ming; Derks, Eske M; Esteva, Isabel; Ehrenfeld, Jesse; Heijer, Martin Den; Posthuma, Danielle; Raynor, Lewis; Tishelman, Amy; Davis, Lea K


    The American Psychological Association defines gender identity as, "A person's deeply-felt, inherent sense of being a boy, a man, or a male; a girl, a woman, or a female; or an alternative gender (e.g., genderqueer, gender nonconforming, gender neutral) that may or may not correspond to a person's sex assigned at birth or to a person's primary or secondary sex characteristics" (American Psychological Association, Am Psychol 70(9):832-864, 2015). Here we review the evidence that gender identity and related socially defined gender constructs are influenced in part by innate factors including genes. Based on the data reviewed, we hypothesize that gender identity is a multifactorial complex trait with a heritable polygenic component. We argue that increasing the awareness of the biological diversity underlying gender identity development is relevant to all domains of social, medical, and neuroscience research and foundational for reducing health disparities and promoting human-rights protections for gender minorities.

  19. The Author Has the Last Word: Buddy Editing in a First-Grade Classroom (United States)

    Auger, Jessie L.


    In this essay, Jessie L. Auger reflects on the practice of Buddy Editing in her first-grade classroom as an opportunity for student and teacher learning. By explicitly revealing her pedagogical approach and sharing transcripts of students' engagement with her Buddy Editing protocol, Auger presents the dynamics of a learning partnership that…

  20. BudBurst Buddies: Introducing Young Citizen Scientists to Plants and Environmental Change (United States)

    Ward, D.; Gardiner, L. S.; Henderson, S.


    As part of Project BudBurst, the BudBurst Buddies recently moved to the National Ecological Network (NEON) as part of its Education and Public Engagement efforts. The BudBurst Buddies ( were created to engage elementary school age children in the science of observing plants and the timing of phenological (life cycle) events. BudBurst Buddies is a part of the Project BudBurst national citizen science initiative (, which allows individuals to engage in the scientific process, contributing to a better understanding of climate change while increasing public awareness of phenology and the impacts of climate change on plants. As a first step towards engaging the next generation of citizen scientists, BudBurst Buddies provides the opportunity for children to gain experience with scientific research and increases awareness of how plants change throughout the year. Hundreds of young students have participated in the inaugural year of BudBurst Buddies. Children can participate in BudBurst Buddies on their own, with their families, or in formal or informal education settings. The program was recently highlighted by education staff at the New York Hall of Science and numerous classrooms have been implementing this resource as part of their curriculum. Each child who participates creates a journal about a plant of his or her choosing, makes observations of the plant over the growing season and submits findings online, earning an official BudBurst Buddies certificate. An online storybook for kids tells how two children, Lily and Sage, observed plants in their neighborhood and became BudBurst Buddies. This presentation will provide an overview of the BudBurst Buddies resources including a new implementation guide and will also share feedback from the first year of implementation.

  1. Buddy taping: is it a safe method for treatment of finger and toe injuries? (United States)

    Won, Sung Hun; Lee, Sanglim; Chung, Chin Youb; Lee, Kyoung Min; Sung, Ki Hyuk; Kim, Tae Gyun; Choi, Young; Lee, Sang Hyeong; Kwon, Dae Gyu; Ha, Jae Hong; Lee, Seung Yeol; Park, Moon Seok


    Buddy taping is a well known and useful method for treating sprains, dislocations, and other injuries of the fingers or toes. However, the authors have often seen complications associated with buddy taping such as necrosis of the skin, infections, loss of fixation, and limited joint motion. To our knowledge, there are no studies regarding the complications of buddy taping. The purpose of this study was to report the current consensus on treating finger and toe injuries and complications of buddy taping by using a specifically designed questionnaire. A questionnaire was designed for this study, which was regarding whether the subjects were prescribed buddy taping to treat finger and toe injuries, reasons for not using it, in what step of injury treatment it was use, indications, complications, kinds of tape for fixation, and special methods for preventing skin injury. Fifty-five surgeons agreed to participate in the study and the survey was performed in a direct interview manner at the annual meetings of the Korean Pediatric Orthopedic Association and Korean Society for Surgery of the Hand, in 2012. Forty-eight surgeons (87%) used buddy taping to treat finger and toe injuries, especially proximal interphalangeal (PIP) injuries of the hand, finger fractures, toe fractures, metacarpophalangeal injuries of the hand, and PIP injuries of the foot. Sixty-five percent of the surgeons experienced low compliance. Forty-five percent of the surgeons observed skin injuries on the adhesive area of the tape, and skin injuries between the injured finger and healthy finger were observed by 45% of the surgeons. This study sheds light on the current consensus and complications of buddy taping among physicians. Low compliance and skin injury should be considered when the clinician treats finger and toe injuries by using buddy taping.

  2. BudBurst Buddies: A New Tool for Engaging the Youngest Citizen Scientists (United States)

    Gardiner, L. S.; Henderson, S.; Ward, D.


    BudBurst Buddies ( introduces elementary school age children to the science of observing plants and the timing of phenological (life cycle) events. BudBurst Buddies is a new part of the Project BudBurst national citizen science initiative (, which allows individuals to engage in the scientific process, contributing to a better understanding of climate change while increasing public awareness of phenology and the impacts of climate change on plants. As a first step towards engaging the next generation of citizen scientists, BudBurst Buddies provides the opportunity for children to gain experience with scientific research and increases awareness of how plants change throughout the year. Children can participate in BudBurst Buddies on their own, with their families, or in formal or informal education settings. Each child who participates creates a journal about a plant of his or her choosing, makes observations of the plant over the growing season and submits findings online, earning an official BudBurst Buddies certificate. An online storybook for kids tells how two children, Lily and Sage, observed plants in their neighborhood and became BudBurst Buddies. This presentation will provide an overview of the BudBurst Buddies newly developed resources. BudBurst Buddies is a part of Project BudBurst, a national citizen science program coordinated by the National Ecological Observatory Network (NEON) and the Chicago Botanic Garden. Funding for this resource was provided by NEON, NSF, NASA, and the National Geographic Education Foundation.

  3. The new biological anthropology: bringing Washburn's new physical anthropology into 2010 and beyond--the 2008 AAPA luncheon lecture. (United States)

    Fuentes, Agustin


    Nearly 60 years ago, Sherwood Washburn issued a call for a "New Physical Anthropology," a transition from measurement and classification toward a focus on the processes and mechanisms of evolutionary change. He advocated multidisciplinary and interdisciplinary approaches to the understanding of human behavior, biology, and history. Many interpret this as a call for a practice that is both biological and anthropological. Is this what we do? Are we biological anthropologists yet? In this essay, I explore what we, Physical Anthropologists, as a discipline are doing in the context of a New Physical Anthropology, where we might be headed, and why this discussion is crucial to our relevance. Copyright © 2010 Wiley-Liss, Inc.

  4. The "drinking-buddy" scale as a measure of para-social behavior. (United States)

    Powell, Larry; Richmond, Virginia P; Cantrell-Williams, Glenda


    Para-social behavior is a form of quasi-interpersonal behavior that results when audience members develop bonds with media personalities that can resemble interpersonal social interaction, but is not usually applied to political communication. This study tested whether the "Drinking-Buddy" Scale, a simple question frequently used in political communication, could be interpreted as a single-item measure of para-social behavior with respect to political candidates in terms of image judgments related to interpersonal attraction and perceived similarity to self. The participants were college students who had voted in the 2008 election. They rated the candidates, Obama or McCain, as drinking buddies and then rated the candidates' perceived similarity to themselves in attitude and background, and also the social and task attraction to the candidate. If the drinking-buddy rating serves as a proxy measure for para-social behavior, then it was expected that participants' ratings for all four kinds of similarity to and attraction toward a candidate would be higher for the candidate they chose as a drinking buddy. The directional hypotheses were supported for interpersonal attraction, but not for perceived similarity. These results indicate that the drinking-buddy scale predicts ratings of interpersonal attraction, while voters may view perceived similarity as an important but not essential factor in their candidate preference.

  5. To reiterate the concept of self-aid and buddy-aid for combat wounded

    Directory of Open Access Journals (Sweden)

    Zhong-jie HE


    Full Text Available Explore new concept of self-aid and buddy-aid for combat wounded based on the emergency timeliness and the challenges we are going to face in the future combats, the importance of self-aid, buddy-aid and rescue are discussed. The concept and characteristics of self-aid and buddy-aid in our army are reviewed, and the care of the wounded in foreign armies were reviewed. Based on the experiences gained from previous combats, and the results of "Medical Service Mission-2014 Drill", it was believed that the emergency rescue of battle wounded should follow the timeliness rule and the principle of self-aid and buddy-aid technology. It might be beneficial to use cell protective agent, urgent relief of life-threatening conditions such as profuse bleeding from extremities, suffocation, pneumothorax, and traumatic shock etc., in order to stabilize the general condition of the wounded, according to the regime of "Platinum 10 minutes" and "golden 1 hour", self-aid and buddy-aid might play an important role in preventing early death and late morbidity of the wounded, thus helps reduce the mortality rate or the victims of combat wounds. DOI: 10.11855/j.issn.0577-7402.2015.11.01

  6. Preschoolers' Engagement with Reading Behaviours: A Statistical Discourse Analysis of Peer Buddy-Reading Interactions (United States)

    Christ, Tanya; Chiu, Ming Ming; Wang, X. Christine


    Developing reading behaviours in early childhood is essential for later reading comprehension. This study explored how peer buddy reading could potentially support emergent readers' engagement with reading behaviours. Across 40 buddy-reading events, 14 preschoolers (ages 4.0-5.5 years) produced 1,359 conversation turns, which were coded for a…

  7. What new cell biology findings could bring to therapeutics: is it time for a phenome-project in Toxoplasma gondii?

    Directory of Open Access Journals (Sweden)

    Markus Meissner


    Full Text Available "If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat" (SunTzu the Art of War, 544-496 BC. Although written for the managing of conflicts and winning clear victories, this basic guideline can be directly transferred to our battle against apicomplexan parasites and how to focus future basic research in order to transfer the gained knowledge to a therapeutic intervention stratey. Over the last two decades the establishment of several key-technologies, by different groups working on Toxoplasma gondii, made this important human pathogen accessible to modern approaches in molecular cell biology. In fact more and more researchers get attracted to this easy accessible model organism to study specific biological questions, unique to apicomplexans. This fascinating, unique biology might provide us with new therapeutic options in our battle against apicomplexan parasites by finding its Achilles' heel. In this article we argue that in the absence of a powerful high throughput technology for the characterisation of essential gene of interests a coordinated effort should be undertaken to convert our knowledge of the genome into one of the phenome.

  8. Does having a buddy help women with young children increase physical activity? Lessons learned from a pilot study. (United States)

    Choi, JiWon; Fukuoka, Yoshimi


    A 12-week pilot controlled trial of a physical activity (PA) buddy program was designed for women with young children. Conducted in January 2015 through March 2016, 49 women (mean age = 36.4 ± 4.8 years) were randomized to one of two groups. Both conditions received an in-person session, weekly step goals based on their baseline number of steps, an accelerometer, and its mobile app. Only women assigned to the intervention group brought their buddies and exercised together at least once per week. Buddies also received an accelerometer and its mobile app. Among 47 women who completed the study, we found no significant difference between groups in changes in the mean number of daily steps for the prior week (p = 0.56). When women were categorized into three groups based on change in buddies' PA, those with inactive buddies had significantly less change in number of steps than those with an active buddy and those in the control group (p < 0.018). Those with an active buddy also had higher friend social support scores for PA than the other two groups (p = 0.05). Thus, to improve PA, creating a social environment in which women associate with active individuals may be necessary.

  9. Cyber Buddy Is Better than No Buddy: A Test of the Köhler Motivation Effect in Exergames. (United States)

    Feltz, Deborah L; Forlenza, Samuel T; Winn, Brian; Kerr, Norbert L


    Although exergames are popular, few people take advantage of the potential of group dynamics to motivate play (and achieve associated health benefits). One motivation gain phenomenon has shown promise for motivating greater effort in partnered exergames: The Köhler effect (working at a task with a more capable partner where one's performance is indispensable to the group). This article examines whether a Köhler effect can be demonstrated in an exergame by exercising with a moderately superior humanoid, software-generated partner. Male and female (n=120; mean age, 19.41 years) college students completed a series of plank exercises using "CyBuddy Exercise," a program developed specifically for this study. In a lab in an academic building, participants completed the exercises individually and, after a rest, were randomly assigned to complete the same exercises again, but with a "live" human partner (HP) presented virtually, a nearly-human-like, humanoid partner (NHP), a hardly human-like, software-generated partner (HHP), or a no-partner control condition (IC), with equal numbers in each group (i.e., n=30). Exercise persistence, perceived exertion, self-efficacy beliefs, enjoyment, and intentions to exercise were recorded and analyzed. A 4×2 analysis of variance on the (Block 2 - Block 1) difference scores showed that a significant Köhler motivation gain was observed in all partner conditions (compared with IC), but persistence was significantly greater with HPs than with either NHP or HHP humanoid partners (Pmotivation gain in exergames, but not as strongly as a partner who is thought to be human.

  10. Emergent Readers' Social Interaction Styles and Their Comprehension Processes during Buddy Reading (United States)

    Christ, Tanya; Wang, X. Christine; Chiu, Ming Ming


    To examine the relations between emergent readers' social interaction styles and their comprehension processes, we adapted sociocultural and transactional views of learning and reading, and conducted statistical discourse analysis of 1,359 conversation turns transcribed from 14 preschoolers' 40 buddy reading events. Results show that interaction…

  11. The impact of a buddy system on the self-care behaviours of women ...

    African Journals Online (AJOL)

    The impact of a buddy system on the self-care behaviours of women living with ... A needs assessment done among HIV-positive (HIV+ve) people in Botswana in ... the services of COCEPWA (Coping Centre for People with Aids) during 2002.

  12. K9 Buddies: A Program of Guide Dogs for the Blind (United States)

    Ritter, Joanne


    Today, exceptional dogs that have been specially bred and socialized are paired with children who are blind or visually impaired. These dogs, called "K9 Buddies," are from Guide Dogs for the Blind, a national nonprofit organization with a mission to offer skilled mobility dogs and training free-of-charge to adults with visual impairments…

  13. Impact of the Reading Buddies Program on Reading Level and Attitude Towards Reading

    Directory of Open Access Journals (Sweden)

    Hayley Dolman


    Full Text Available Objective – This research examines the Reading Buddies program at the Grande Prairie Public Library, which took place in July and August of 2011 and 2012. The Reading Buddies program pairs lower elementary students with teen volunteers for reading practice over the summer. The aim of the study was to discover how much impact the program would have on participating children’s reading levels and attitudes towards reading.Methods – During the first and last sessions of the Reading Buddies program, the participants completed the Elementary Reading Attitudes Survey (ERAS and the Graded Word Recognition Lists from the Bader Reading and Language Inventory (6th ed., 2008.Participants were also asked for their grade and sex, and the program coordinator kept track of attendance. Results – There were 37 Reading Buddies participants who completed both the pre- and post-tests for the study. On average, the program had a small positive effect on participants’ reading levels and a small negative effect on their attitudes towards reading. There was a larger range of changes to the ERAS scores than to the reading test scores, but most participants’ scores did not change dramatically on either measure.Conclusions – Although findings are limited by the small size of the data-set, results indicate that many of the Reading Buddies participants maintained their reading level over the summer and had a similar attitude towards reading at the end of the program. On average, reading levels increased slightly and attitudes towards reading were slightly more negative. Many factors could not be taken into account during the study (e.g., the amount of reading done at home. A study with a control group that did not participate in the program could help to assess whether the program helped to combat summer learning loss.

  14. Biology

    Indian Academy of Sciences (India)

    I am particularly happy that the Academy is bringing out this document by Professor M S. Valiathan on Ayurvedic Biology. It is an effort to place before the scientific community, especially that of India, the unique scientific opportunities that arise out of viewing Ayurveda from the perspective of contemporary science, its tools ...

  15. Your Health Buddies Matter: Preferential Selection and Social Influence on Weight Management in an Online Health Social Network. (United States)

    Meng, Jingbo


    A growing number of online social networks are designed with the intention to promote health by providing virtual space wherein individuals can seek and share information and support with similar others. Research has shown that real-world social networks have a significant influence on one's health behavior and outcomes. However, there is a dearth of studies on how individuals form social networks in virtual space and whether such online social networks exert any impact on individuals' health outcomes. Built on the Multi-Theoretical Multilevel (MTML) framework and drawing from literature on social influence, this study examined the mechanisms underlying the formation of an online health social network and empirically tested social influence on individual health outcomes through the network. Situated in a weight management social networking site, the study tracked a health buddy network of 709 users and their weight management activities and outcomes for 4 months. Actor-based modeling was used to test the joint dynamics of preferential selection and social influence among health buddies. The results showed that baseline, inbreeding, and health status homophily significantly predicted preferential selection of health buddies in the weight management social networking site, whereas self-interest in seeking experiential health information did not. The study also found peer influence of online health buddy networks on individual weight outcomes, such that an individual's odds of losing weight increased if, on average, the individual's health buddies were losing weight.

  16. Support like a walking stick: parent-buddy matching for language and culture in the NICU. (United States)

    Ardal, Frida; Sulman, Joanne; Fuller-Thomson, Esme


    (1) To explore the experience of non-English-speaking mothers with preterm, very low birth weight (VLBW) infants (,1,500 g); and (2) to examine mothers' assessment of a peer support program matching them with linguistically and culturally similar parent-buddies. An exploratory, qualitative analysis based on grounded theory. A convenience sample of eight mothers from four of the most prevalent non-English-speaking cultures (Spanish, Portuguese, Chinese, and Tamil) in an urban Canadian-teaching hospital. Non-Anglophone mothers' experience and support in the NICU. Study mothers experienced intense role disequilibrium during the unanticipated crisis of preterm birth of a VLBW infant; situational crises owing to the high-tech NI CU environment and their infant's condition; and developmental crises with feelings of loss, guilt, helplessness, and anxiety. Language barriers compounded the difficulties. Parent-buddies helped non-English-speaking mothers mobilize their strengths. Culture and language are important determinants of service satisfaction for non-English-speaking mothers. Linguistically congruent parent-to-parent matching increases access to service.

  17. NCI Symposium on Chromosome Biology to bring together internationally renowned experts in the fields of chromosome structure and function | Center for Cancer Research (United States)

    The Center for Cancer Research’s Center of Excellence in Chromosome Biology is hosting the “Nuclear Structure, Genome Integrity and Cancer Symposium“ on November 30 - December 1, 2016 at the Natcher Conference Center, Bethesda, Maryland. Learn more ...

  18. Pain buddy: A novel use of m-health in the management of children’s cancer pain (United States)

    Fortier, Michelle A.; Chung, Winnie W.; Martinez, Ariana; Gago-Masague, Sergio; Sender, Leonard


    Background Over 12,000 children are diagnosed with cancer every year in the United States. In addition to symptoms associated with their disease, children undergoing chemotherapy frequently experience significant pain, which is unfortunately often undertreated. The field of m-Health offers an innovative avenue for pain assessment and intervention in the home setting. The current study describes the development and initial evaluation of a tablet-based program, Pain Buddy, aimed to enhance pain management and foster improved quality of life in children ages 8–18 years undergoing cancer treatment. Methods An animated avatar-based tablet application was developed using state-of-the-art software. Key aspects of Pain Buddy include daily pain and symptom diaries completed by children, remote monitoring of symptoms by uploading patient’s data through internet to a cloud server, cognitive and behavioral skills training, interactive three-dimensional avatars that guide children through the program, and an incentive system to motivate engagement. Twelve children between the ages of 8 and 18 participated in a pilot study of Pain Buddy. Results Children were highly satisfied with the program. Pain and appetite disturbances were most frequently endorsed. Symptom trigger alerts to outside providers were largely related to clinically significant pain. Children infrequently used analgesics, and reported using some non-pharmacological pain management strategies. Conclusion Pain Buddy appears to be a promising tool to improve pain and symptom management in children undergoing cancer treatment. Results from the current study will inform future improvements to Pain Buddy, in preparation for a randomized controlled trial to assess the efficacy of this innovative treatment. PMID:27479493

  19. The effects of a buddy bench on elementary students’ solitary behavior during recess

    Directory of Open Access Journals (Sweden)

    Andrew A. Griffin Jr.


    Full Text Available Social skill instruction and school-wide positive behavior supporthave been found to be effective in treating students with emotional and behavioral disorders. However, students with internalizing behavior are often overlooked for interventions that could improveacademic outcomes and prevent problems that might have serious implications, including social withdrawal, social isolation, and suicidal ideation. In this study, a multiple baseline across participants design was used across two elementary school recess playgrounds to evaluate a “buddy bench” intervention, whichutilized peers to help socially withdrawn students to decrease social isolation behavior. Students in Grades 1 to 6 were observed during recess. Results revealed that from baseline to intervention phases the number of students engaged in solitary recess behavior decreased between 19% and 24%. Most students reported positive attitudes towards the intervention, while teachers were more neutral.

  20. Bringing an "old" biological buffer to coordination chemistry: new 1D and 3D coordination polymers with [Cu(4)(Hbes)(4)] cores for mild hydrocarboxylation of alkanes. (United States)

    Kirillov, Alexander M; Coelho, Jaime A S; Kirillova, Marina V; da Silva, M Fátima C Guedes; Nesterov, Dmytro S; Gruenwald, Katrin R; Haukka, Matti; Pombeiro, Armando J L


    New water-soluble 1D and 3D Cu(II)/Na coordination polymers 1-3 bearing unprecedented [Cu(4)(Hbes)(4)] cores have been easily generated by aqueous-medium self-assembly and fully characterized, thus opening up the use of the common biological buffer H(3)bes, (HO(3)SCH(2)CH(2))N(CH(2)CH(2)OH)(2), in synthetic coordination chemistry. Apart from representing the first isolated and structurally characterized coordination compounds derived from H(3)bes, 1-3 show a remarkable promoting effect in the mild aqueous-medium hydrocarboxylation, by CO and H(2)O, of gaseous alkanes (C(3)H(8) and n-C(4)H(10)) to the corresponding carboxylic acids, which are obtained in up to 95% yields based on the alkane.

  1. Buddies Not Bullies: an approach to bullying prevention education in preschool children, their families and the community. (United States)

    Beauchesne, Michelle A; Farquharson, Patrice E; Beauchemin, Patricia


    Bullying is a traumatic event and has been observed among children as young as four years old. We have designed the Buddies Not Bullies initiative, which is a series of projects to help preschool children protect themselves from bullying. We also designed projects to educate the families of these preschool children and their community on the effects of bullying. The Buddies Not Bullies initiative promotes social-emotional development and discourages behaviours that might lead to bullying. In this article the initiatives designed to engage preschool children and raise awareness, including an interactive puppet show, are outlined. The authors also discuss how they evaluated the success of these projects and the implications for all professionals caring for young children.

  2. Base fractures of the fifth proximal phalanx can be treated conservatively with buddy taping and immediate mobilisation

    DEFF Research Database (Denmark)

    Vadstrup, Lars S; Jørring, Stig; Bernt, Peter


    INTRODUCTION: Treatment of base fractures in the proximal phalanx depends on the fracture type, the degree of displacement and whether fracture reduction is stable or not. Internal fixation often leads to decreased mobility of the injured finger despite exact reduction of the fracture. Our...... treatment is focused upon function and to a lesser extent on exact reposition of the fractured fifth digit. Buddy taping was used after initial, closed reduction of the fracture allowing for immediate mobilisation. MATERIAL AND METHODS: This was a prospective follow-up study of 53 consecutive conservatively...... managed base fractures in 53 patients with a mean age of 39 years. All fractures were treated with buddy taping to the fourth digit and immediate mobilisation. RESULTS: The subjective outcome showed high overall satisfaction, and only four patients reported mild pain at rest or work. Malrotation was noted...

  3. Bringing down the trash (United States)

    Ornes, Stephen


    The density of junk orbiting the Earth is at or near a critical value beyond which this man-made debris will self-perpetuate, forming many smaller pieces that are even more of a problem. Stephen Ornes reports on the latest ideas about how to bring down the trash.

  4. Bringing Scientists to Life (United States)

    Casey, Peter


    In this article, the author describes how he brings scientists to life when he visits schools. Having retired from teaching Drama and Theatre Studies in Liverpool for more than thirty years, the author set up his one-man Theatre-in-Education company, Blindseer Productions, and now takes his portrayals of Darwin, Galileo and Einstein to schools…

  5. SDSS-IV MaNGA: bulge-disc decomposition of IFU data cubes (BUDDI) (United States)

    Johnston, Evelyn J.; Häußler, Boris; Aragón-Salamanca, Alfonso; Merrifield, Michael R.; Bamford, Steven; Bershady, Matthew A.; Bundy, Kevin; Drory, Niv; Fu, Hai; Law, David; Nitschelm, Christian; Thomas, Daniel; Roman Lopes, Alexandre; Wake, David; Yan, Renbin


    With the availability of large integral field unit (IFU) spectral surveys of nearby galaxies, there is now the potential to extract spectral information from across the bulges and discs of galaxies in a systematic way. This information can address questions such as how these components built up with time, how galaxies evolve and whether their evolution depends on other properties of the galaxy such as its mass or environment. We present bulge-disc decomposition of IFU data cubes (BUDDI), a new approach to fit the two-dimensional light profiles of galaxies as a function of wavelength to extract the spectral properties of these galaxies' discs and bulges. The fitting is carried out using GALFITM, a modified form of GALFIT which can fit multiwaveband images simultaneously. The benefit of this technique over traditional multiwaveband fits is that the stellar populations of each component can be constrained using knowledge over the whole image and spectrum available. The decomposition has been developed using commissioning data from the Sloan Digital Sky Survey-IV Mapping Nearby Galaxies at APO (MaNGA) survey with redshifts z 22 arcsec, but can be applied to any IFU data of a nearby galaxy with similar or better spatial resolution and coverage. We present an overview of the fitting process, the results from our tests, and we finish with example stellar population analyses of early-type galaxies from the MaNGA survey to give an indication of the scientific potential of applying bulge-disc decomposition to IFU data.

  6. Bringing "indigenous" ownership back

    DEFF Research Database (Denmark)

    Kragelund, Peter


    understanding of how processes of exclusion interact with domestic politics in Zambia. It argues that the Citizens Economic Empowerment Commission, a new institution to bring ownership back to Zambians, builds on a long tradition of nationalist policies in Zambia, while its actual work is strictly related...... to the critique of the growing foreign dominance over the economy, and in particular of the upsurge in Chinese investments....

  7. Bringing Things Together

    DEFF Research Database (Denmark)

    Gundelach, Peter


    The first sample surveys in the latter parts of the 19th century were an intellectual social movement. They were motivated by the intention to improve the economic and political conditions of workers. The quantitative survey was considered an ideal because it would present data about the workers...... as facts, i.e. establish a scientific authoritative truth. In a case study from Denmark, the paper shows how the first survey - a study of seamstresses - was carried out by bringing several cognitive and organizational elements together: a network of researchers, a method for sampling, the construction...

  8. Bringing science to business (United States)

    Lemetti, Paul


    Bringing science to business seems rather straight forward. Technology is constantly moving forward and new inventions are being brought into the market place. Science parks and technology parks have sprung out all around the globe competing against each other and trying to keep their own doors open by bringing in new business, thereby creating much needed income to keep their operations moving forward. However, only a small handful ofthese centers around the world can truly be considered successful. It is the relationship between the scientists, start-up business, local universities, local government, and invited bigger business that allows the parks to succeed. The individual scientist wishing to enter into business or just hoping to get his invention into the pool of potential ideas; which might end up in the hands of an entrepreneur or an established company, is not always that simple. Universal success principles must be embraced to ensure success. One must believe in oneself and to strive for excellence. One must be able to see the other persons viewpoint and adapt and change his behavior in order to succeed. One must learn to create trust as well as learn to trust. Furthermore, one must learn to focus on the why of the process and not on the how. A market must be identified and benefits of local area must be sold to potential investor or business partners. A local success has in part to do with local cooperation.

  9. Bringing minds together. (United States)

    Abele, John


    Boston Scientific founder John Abele has been party to his share of groundbreaking innovations over the years. But the revolutionary advances in medical science that these breakthroughs brought about were not the efforts of one firm alone, let alone one inventor. Abele tells two fascinating stories of collaboration--one about Jack Whitehead's upending of hospitals' blood and urine testing procedures and the other about Andreas Gruentzig's success in bringing balloon catheterization into the cardiology mainstream. Both Whitehead and Gruentzig spearheaded the emergence of entirely new fields, bringing together scientist-customers to voluntarily develop standards, training programs, new business models, and even a specialized language to describe their new field. The process of collaboration, Abete says, is fraught with contradictions and subtlety. It takes consummate leadership skills to persuade others to spend countless hours solving important problems in partnership with people they don't necessarily like. Moreover, managing egos so that each person's commitment, energy, and creativity is unleashed in a way that doesn't disadvantage others requires an impresario personality. Finally, true authenticity--something that few people can project--is critical for earning customers' trust and convincing them that their valuable contributions won't be used for anything other than moving the technology forward.

  10. Techniques to Bring Up Mucus (United States)

    ... COPD: Lifestyle Management Techniques to Bring Up Mucus Techniques to Bring Up Mucus Make an Appointment Refer ... breathing may become difficult, and infection may occur. Techniques to remove mucus are often done after using ...

  11. The Combined Effects of Social Script Training and Peer Buddies on Generalized Peer Interaction of Children with ASD in Inclusive Classrooms (United States)

    Hundert, Joel; Rowe, Sarah; Harrison, Erin


    One of the challenges in supporting young children with Autism Spectrum Disorder (ASD) in inclusive classrooms is the generalization of improved social behaviors. Using a multiple-baseline design across participants, this study examined the generalized effects of social script training alone and combined with peer buddies on the interactive play…

  12. Improving Teacher Comfort Levels and Self-Efficacy with Technology Integration and Application of Technology into the Elementary Education Curriculum through the Tech Buddy Program (United States)

    Adams, Susan Christine


    Professional Development for technology integration into the elementary curriculum has been a costly and frequently ineffective endeavor. The idea for the Tech Buddy model came from this frustration. Teaming a teacher who had high comfort and self-efficacy levels with technology, however who still had much to learn, together with a teacher who was…

  13. Getting the terminology right in sexual health research: the importance of accurately classifying fuck buddies among men who have sex with men. (United States)

    Bellhouse, Clare; Walker, Sandra; Fairley, Christopher K; Chow, Eric Pf; Bilardi, Jade E


    The aim of this report was to raise the issue of the definition and classification of partner terminology in men who have sex with men (MSM) research, particularly in regards to 'fuck buddies'. If definitions in research differ from general consensus in the MSM population, it is possible that public health strategies will be ineffective as the target population may be inaccurate. Thirty semistructured interviews with MSM attending the Melbourne Sexual Health Centre were conducted, focusing on the willingness to change sexual practices to reduce the risk of pharyngeal gonorrhoea. As part of these interviews, men were also asked their views on the terminology they used to describe their relationships and sexual partners. The degree of emotional attachment often defined the type or classification of relationships. There was a consensus among men that partners they engaged with for 'sex only' were classified as casual partners and partners with whom there was an emotional attachment or formalisation of the relationship were classified as 'regular partners'. However, the classification of 'fuck buddy' as a regular or casual partner was less clear. Further research is needed to ascertain the ways in which men conceptualise sexual relationships and define or classify partner types, particularly 'fuck buddy' relationships. A third category for sexual relationships should be considered to encapsulate fuck buddy relationships. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

  14. Nutritional intervention and physical training in malnourished frail community-dwelling elderly persons carried out by trained lay "buddies": study protocol of a randomized controlled trial. (United States)

    Dorner, Thomas E; Lackinger, Christian; Haider, Sandra; Luger, Eva; Kapan, Ali; Luger, Maria; Schindler, Karin E


    In elderly persons frailty and malnutrition are very common and can lead to serious health hazards such as increased mortality, morbidity, dependency, institutionalization and a reduced quality of life. In Austria, the prevalence of frailty and malnutrition are increasing steadily and are becoming a challenge for our social system. Physical training and adequate nutrition may improve this situation. In this randomized controlled trial, 80 malnourished frail community-dwelling patients (≥ 65 years) hospitalized at wards for internal medicine are recruited. Additionally, 80 lay volunteers (≥ 50 years), named buddies are recruited and subsequently trained regarding health enhancing physical activity and nutrition in four standardized training sessions. These buddies visit the malnourished frail persons at home twice a week for about one hour during an initial period of 10-12 weeks. While participants allocated to the intervention group (n = 40) receive intervention to improve their fluid intake, protein and energy intake, perform strength training and try to increase their baseline activities, the control group (n = 40) only gets home visits without any intervention. After 10-12 weeks, both, the intervention and the control group, receive the nutritional intervention and the physical training. Health, nutritional and frailty status, physical fitness, body composition and chronic inflammation of buddies and frail persons are recorded before the intervention, after 10-12 weeks, 6 and 12 months. To your knowledge this trial is the first of its kind to provide nutritional and physical activity interventions to malnourished frail community-dwelling persons by trained lay buddies, in which an improvement of the frail persons' and the buddies' health status is measured. This study assesses the efficacy of such an intervention and may offer new perspectives for the management of frailty and malnutrition. [corrected], NCT01991639.

  15. Bringing Gravity to Space (United States)

    Norsk, P.; Shelhamer, M.


    This panel will present NASA's plans for ongoing and future research to define the requirements for Artificial Gravity (AG) as a countermeasure against the negative health effects of long-duration weightlessness. AG could mitigate the gravity-sensitive effects of spaceflight across a host of physiological systems. Bringing gravity to space could mitigate the sensorimotor and neuro-vestibular disturbances induced by G-transitions upon reaching a planetary body, and the cardiovascular deconditioning and musculoskeletal weakness induced by weightlessness. Of particular interest for AG during deep-space missions is mitigation of the Visual Impairment Intracranial Pressure (VIIP) syndrome that the majority of astronauts exhibit in space to varying degrees, and which presumably is associated with weightlessness-induced fluid shift from lower to upper body segments. AG could be very effective for reversing the fluid shift and thus help prevent VIIP. The first presentation by Dr. Charles will summarize some of the ground-based and (very little) space-based research that has been conducted on AG by the various space programs. Dr. Paloski will address the use of AG during deep-space exploration-class missions and describe the different AG scenarios such as intra-vehicular, part-of-vehicle, or whole-vehicle centrifugations. Dr. Clement will discuss currently planned NASA research as well as how to coordinate future activities among NASA's international partners. Dr. Barr will describe some possible future plans for using space- and ground-based partial-G analogs to define the relationship between physiological responses and G levels between 0 and 1. Finally, Dr. Stenger will summarize how the human cardiovascular system could benefit from intermittent short-radius centrifugations during long-duration missions.

  16. An interprofessional collaborative approach in the development of a caries risk assessment mobile tablet application: My Smile Buddy. (United States)

    Chinn, Courtney H; Levine, June; Matos, Sergio; Findley, Sally; Edelstein, Burton L


    Given the rising trend in early childhood caries (ECC) and the wide disparities that exist in pediatric oral health, risk assessment for ECC has become increasingly important. The purpose of this paper is to describe lessons learned from an Interprofessional Collaboration (IPC) approach in the planning, development, and pilot testing of an electronic interactive ECC risk assessment application--My Smile Buddy (MSB). Five focus groups were conducted during the assessment and development phases of MSB. Community Health Workers (CHW) then facilitated MSB with 35 mothers from the local community. MSB was well accepted by mothers and scored well in usability and usefulness by CHWs. Lessons learned during MSB development included recognizing CHW understanding of local community attitudes regarding oral health and access to dental care and that power-sharing is required in order to create an intervention that is both engaging and accepted by the community.

  17. The impact of a buddy system on the self-care behaviours of women living with HIV/AIDS in Botswana

    Directory of Open Access Journals (Sweden)

    Johanna R Zuyderduin


    Full Text Available A needs assessment done among HIV-positive (HIV+ve people in Botswana in 2000 indicated that these people required social support. Based on these results, a buddy system for and by HIV+ve women was instituted in Botswana during 2002. This study examined the impact of the buddy system on the self-care behaviours of 116 HIV+ve women volunteers who used the services of COCEPWA (Coping Centre for People with Aids during 2002. The convenience sample comprised 39 buddies who completed the buddy training programme, 39 patients assigned to the 39 buddies and 38 controls who lived in areas where the buddy programme did not operate. The results indicate that HIV+ve patients who had buddies showed improved self-care behaviours from April 2002 until November 2002 compared to the controls. These self-care behaviours encompassed informing a number of other people about their HIV+ve status, compliance with tuberculosis treatment, CD4 quantification and adherence to antiretroviral therapy. Although the differences were not always statistically significant, the patients showed greater improvements than the controls in all self-care behaviours. Thus the buddy system might have assisted and empowered the patients to achieve higher levels of self-care behaviours than the controls. Opsomming ’n Behoeftebepaling wat in 2000 van MIV-positiewe (MIV+we persone in Botswana gedoen is, het getoon dat hierdie mense sosiale ondersteuning nodig gehad het. Gebaseer op hierdie bevindinge is ’n “buddy”-stelsel vir en deur MIV+we vroue gedurende 2002 in die land ingestel. Hierdie studie het die impak van die “buddy”-stelsel op die selfsorggedrag van 116 MIV+we vroulike vrywilligers ondersoek wat die dienste van COCEPWA (Coping Centre for People with AIDS gedurende 2002 benut het. Die gerieflikheidsteekproef het uit 39 “buddies” bestaan wat die “buddy”-opleidingsprogram voltooi het, 39 pasiënte wat aan die 39 “buddies” toegewys is en 38 kontrolepati

  18. The impact of a buddy system on the self-care behaviours of women living with HIV/AIDS in Botswana

    Directory of Open Access Journals (Sweden)

    Dirk M van der Wal


    Full Text Available A needs assessment done among HIV-positive (HIV+ve people in Botswana in 2000 indicated that these people required social support. Based on these results, a buddy system for and by HIV+ve women was instituted in Botswana during 2002. This study examined the impact of the buddy system on the self-care behaviours of 116 HIV+ve women volunteers who used the services of COCEPWA (Coping Centre for People with Aids during 2002. The convenience sample comprised 39 buddies who completed the buddy training programme, 39 patients assigned to the 39 buddies and 38 controls who lived in areas where the buddy programme did not operate. The results indicate that HIV+ve patients who had buddies showed improved self-care behaviours from April 2002 until November 2002 compared to the controls. These self-care behaviours encompassed informing a number of other people about their HIV+ve status, compliance with tuberculosis treatment, CD4 quantification and adherence to antiretroviral therapy. Although the differences were not always statistically significant, the patients showed greater improvements than the controls in all self-care behaviours. Thus the buddy system might have assisted and empowered the patients to achieve higher levels of self-care behaviours than the controls. Opsomming ’n Behoeftebepaling wat in 2000 van MIV-positiewe (MIV+we persone in Botswana gedoen is, het getoon dat hierdie mense sosiale ondersteuning nodig gehad het. Gebaseer op hierdie bevindinge is ’n “buddy”-stelsel vir en deur MIV+we vroue gedurende 2002 in die land ingestel. Hierdie studie het die impak van die “buddy”-stelsel op die selfsorggedrag van 116 MIV+we vroulike vrywilligers ondersoek wat die dienste van COCEPWA (Coping Centre for People with AIDS gedurende 2002 benut het. Die gerieflikheidsteekproef het uit 39 “buddies” bestaan wat die “buddy”-opleidingsprogram voltooi het, 39 pasiënte wat aan die 39 “buddies” toegewys is en 38 kontrolepati

  19. Healthy Buddies: a novel, peer-led health promotion program for the prevention of obesity and eating disorders in children in elementary school. (United States)

    Stock, Suzanne; Miranda, Charmaine; Evans, Stacey; Plessis, Suzanne; Ridley, Julia; Yeh, Sophia; Chanoine, Jean-Pierre


    We designed and tested a novel health promotion program for elementary schools that was based on peer teaching from older to younger schoolchildren ("Healthy Buddies"). This prospective pilot study compared the effect of our program (2-3 hours/week, 21 weeks) in 2 Canadian elementary schools (intervention: n = 232 children, the whole school implementing the program; control: n = 151). Older students (4th through 7th grade) were given direct instruction from 1 intervention teacher and were paired with younger students (kindergarten through 3rd grade) for the whole school year. Students in 4th through 7th grade then acted as teachers for their younger "buddies." All lessons included 3 components of healthy living: nutrition, physical activity, and healthy body image. The students first learned how to be positive buddies and learned the 3 components of a healthy life. Thereafter, they learned how to overcome challenges to living a healthy life. Outcome measures (intervention and control schools at the beginning and end of the school year) included validated questionnaires that assessed healthy-living knowledge, behavior and attitude, a 9-minute fitness run, self-competence, body satisfaction, disordered eating symptoms, and anthropometry (BMI, blood pressure, and heart rate). Compared with control students, both older and younger intervention students showed an increase in healthy-living knowledge, behavior, and attitude scores and a smaller increase in systolic blood pressure. BMI and weight increased less in the intervention students in 4th through 7th grade and height more in the intervention students in kindergarten through 3rd grade. Our student-led curriculum improved knowledge not only in older schoolchildren but also in their younger buddies. It also decreased weight velocity in the older students. Student-led teaching may be an efficient, easy-to-implement way of promoting a healthy lifestyle from kindergarten to 7th grade.

  20. Spine Buddy® Supportive Pad Impact on Single-Leg Static Balance and a Jogging Gait of Individuals Wearing a Military Backpack

    Directory of Open Access Journals (Sweden)

    Ward John


    Full Text Available The Spine Buddy® supportive pad was developed to be inserted underneath military backpacks to help disperse the heavy load of the backpack. The purpose of this study was to determine the impact the additional supportive pad had on static balance and a running gait while wearing a military backpack. Forty healthy subjects (age= 27.5 + 5.6 yrs, body height= 1.78 + 0.06 m, body mass= 86.5 + 14.0 kg: mean + SD participated in a static single-leg balance test on a force plate with each lower limb while wearing a 15.9 kg military backpack for 30 s. Following this, participants were randomized to one of two interventions: 1 Intervention, which wore the Spine Buddy® supportive pad underneath their backpack or 2 Control, with no additional supportive pad. Post-intervention measurements of static single-leg balance were then recorded. Afterwards, a similar pre vs post testing schedule and randomization scheme was used to test the impact of the supportive pad on a 5 mph jogging gait using Vicon® cameras. Within-group data were analyzed with a 2-way repeated measures ANOVA. Statistically significant differences were not seen between the control and experimental group for balance and gait variables. Preliminarily, this suggests that the Spine Buddy® supportive pad causes no deleterious effect on static balance and a jogging gait in 18-45 year-old asymptomatic individuals.

  1. A pilot training program for people in recovery of mental illness as vocational peer support workers in Hong Kong - Job Buddies Training Program (JBTP): A preliminary finding. (United States)

    Yam, Kevin Kei Nang; Lo, William Tak Lam; Chiu, Rose Lai Ping; Lau, Bien Shuk Yin; Lau, Charles Ka Shing; Wu, Jen Kei Yu; Wan, Siu Man


    The present study reviews the delivery of a pilot curriculum-mentorship-based peer vocational support workers training in a Hong Kong public psychiatric hospital. The present paper reports (1) on the development of a peer vocational support workers training - Job Buddies Training Program (JBTP) in Hong Kong; and (2) preliminary findings from both quantitative and qualitative perspectives. The curriculum consists of 15-session coursework, 8-session storytelling workshop and 50-hour practicum to provide Supported Employment Peer Service (SEPS) under the mentorship of occupational therapists. Six trainees were assessed using three psychosocial assessments and qualitative methods. Compared to the baseline, the Job Buddies (JB) trainees showed an increase in awareness of their own recovery progress, occupational competence and problem-solving skills at the end of the training. Their perceived level of self-stigma was also lessened. In post-training evaluation, all Job Buddies trainees said they perceived positive personal growth and discovered their own strengths. They also appreciated the help from their mentors and gained mutual support from other trainees and from exposure with various mini-projects in the training. This pilot study provides an example of incorporating peer support and manualized training into existing work rehabilitation service for our JB trainees. Further studies on the effectiveness of service provided by peer support workers and for development on the potential use of peer support workers in other clinical and rehabilitation settings with larger subjects will be fruitful. Copyright © 2016. Published by Elsevier B.V.

  2. Bring Your Own Device or Bring Your Own Distraction (United States)

    Laxman, Kumar; Holt, Craig


    The purpose of this exploratory case study was to investigate the utilisation of Bring Your Own Device (BYOD) technologies in the classroom to determine if students and teachers perceive that the use of a digital device increased a learner's access to learning opportunities within the classroom, and, if the use of digital devices increased their…

  3. Bringing Secrecy into the Open

    DEFF Research Database (Denmark)

    Costas, Jana; Grey, Christopher


    This paper brings into focus the concept of organizational secrecy, defined as the ongoing formal and informal social processes of intentional concealment of information from actors by actors in organizations. It is argued that existing literature on the topic is fragmented and predominantly...

  4. Bringing reality into the classroom

    NARCIS (Netherlands)

    Heck, A.


    Technology offers ample opportunities to bring reality into the classroom. Students and teachers nowadays have many tools to work in an authentic way with real data in mathematics and science education. However, much research and development are still needed to create a consistent learning

  5. BYOD: Bring your own disaster

    CERN Multimedia

    Computer Security Team


    Have you ever heard of “BYOD”? No, it is not a pop band. Try again. It is short for “Bring Your Own Device” (the French use “AVEC” -  “Apporter Votre Equipement personnel de Communication”) and describes an option long since offered at CERN: the possibility to bring along your personal laptop, smartphone or PDA, use it on CERN premises and connect it to the CERN office network. But hold on. As practical as it is, there is also a dark side.   The primary advantage, of course, is having a digital work environment tuned to your needs and preferences. It allows you to continue working at home. Similarly, you always have your music, address books and bookmarks with you. However, as valuable as this is, it is also a responsibility. Laptop theft is happening - outside CERN but also on site. In France, 30% of stolen laptops were stolen out of cars or homes, and 10% during travel. At CERN, on average one ...

  6. Analysis of factors related to military training injury and the effect of self-rescue and buddy rescue on the final result of the injury in tank crew of the armored forces

    Directory of Open Access Journals (Sweden)

    Rong-bin ZHOU


    Full Text Available Objective To analyze the factors related to military training injury and the effect of self-rescue and buddy rescue on the result of the injury in the soldiers.Methods All data were statistically classified with cluster sampling according to the diagnosis standard of Chinese PLA for analysis.Investigation was conducted in 1028 soldiers of the armored forces with questionnaire,and non-condition logistic regression analysis was applied.Results The total incidence of military training injury was 40.2%.Of all the injured soldiers,36.80% of them served for one year only,and the incidence of injury was obviously higher than those who had served in armed forces for 2 or 3 years.Unconditioned regression analysis revealed that the main causes related to military training injury in the soldiers were as follows: the items of training,the terrain feature,motion sickness,self-rescue and buddy rescue training,and whether the action consistent with the standards.The rehabilitation rate within one month was significantly higher in those who underwent self-rescue or buddy rescue(93.8% and 94.2%,respectively than those who did not undergo self-rescue or buddy rescue(76.3%,76.7%,respectively,P < 0.001.Conclusions The incidence of military training injury in the armored forces is high.It should be emphysized that soldiers with one year of military service should be partioularly taken care to prevent from injuries.Many factors may influence the military training injury,and protective measures should be taken.Those who have the knowledge of self-rescue or undergo buddy rescue will have higher rehabilitation rate within one month.

  7. When Biology & Physics Meet Exhibition Science Bringing Nations Together

    CERN Multimedia


    Politicians have come to realize the necessity of uniting the efforts of scientists. This is clear from the address of the President of Georgia E Shevardnadze to the JINR scientists : "The idea of collective participation in fundamental research is not only valuable per se. It is another opportunity for harmonious co-operation of representatives of different peoples and scientific schools in the single process of evolution of the world civilisation".

  8. When Biology & Physics Meet Exhibition Science Bringing Nations Together

    CERN Multimedia


    Politicians have come to realize the necessity of uniting the efforts of scientists. This is clear from the address of the President of Georgia Eduard Shevardnadze to the JINR scientists: "The idea of collective participation in fundamental research is not only valuable per se. It is another opportunity for harmonious co-operation of representatives of different peoples and scientific schools in the single process of evolution of the world civilization."

  9. Management strategies of Bring Your Own Device

    Directory of Open Access Journals (Sweden)

    Li Peixuan


    Full Text Available The rapid development of mobile Internet and mobile terminals promote business office system from PC to mobile terminals gradually. Thus Bring Your Own Device (BYOD has become one of the important development trends of enterprise office mode. We analyse the driving factors of implementing Bring Your Own Device, then point out some problems in the process of implementing Bring Your Own Device. Further, we propose the corresponding management strategies of Bring Your Own Device in order to provide references for enterprises to meet the need of mobile office.

  10. [What brings neurobiology to addictions? (United States)

    Lenoir, Magalie; Noble, Florence


    Addictions are multifactorial, and there are no experimental models replicating all aspects of this pathology. The development of animal models reproducing the clinical symptoms of addictions allows significant advances in the knowledge of the neurobiological processes involved in addiction. Preclinical data highlight different neuroadaptations according to the routes of administration, speeds of injection and frequencies of exposure to drugs of abuse. The neuroadaptations induced by an exposure to drugs of abuse follow dynamic processes in time. Despite significant progresses in the knowledge of neurobiology of addictions allowing to propose new therapeutic targets, the passage of new drugs in clinical is often disappointing. The lack of treatment efficacy reported in clinical trials is probably due to a very important heterogeneity of patients with distinct biological and genetic factors, but also with different patterns of consumption that can lead to different neuroadaptations, as clearly observed in preclinical studies. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  11. Healthy Family 2009: Bringing in Baby (United States)

    ... Navigation Bar Home Current Issue Past Issues Healthy Family 2009 Bringing in Baby Past Issues / Winter 2009 ... Down syndrome and other common genetic disorders, inherited family conditions, such as Duchenne muscular dystrophy, or disorders ...

  12. Exercise Brings Bone Benefits that Last (United States)

    ... Special Issues Subscribe May 2014 Print this issue Exercise Brings Bone Benefits that Last En español Send ... lose bone. Studies of animals have shown that exercise during periods of rapid growth can lead to ...

  13. Bring Your Own Technology (BYOT to Education

    Directory of Open Access Journals (Sweden)

    Joseph M. Woodside


    Full Text Available In an effort to reduce costs and increase worker satisfaction, many businesses have implemented a concept known as Bring Your Own Device (BYOD or Bring Your Own Technology (BYOT. Similarly, many school districts are beginning to implement BYOT policies and programs to improve educational learning opportunities for students who have a wide variety of technology devices. BYOT allow districts with limited budgets enable usage of technology while improving student engagement. This paper explores the technology devices, and educational implications of policies, device management, security and included components.

  14. Waleli: Bringing Wireless Opportunities to Life

    NARCIS (Netherlands)

    Kirwan, P.M.; Gutierrez, Jairo


    This chapter tells the development story of Waleli, a high-tech company utilizing the latest proven developments in wireless communications to bring innovations to the market. It presents the journey of the firm through the entrepreneurial process, from initial idea right through to value creation.

  15. Bringing History Alive in the Classroom! (United States)

    McRae, Lee, Ed.


    This document consists of the first four issues of a serial publication, "Bringing History Alive in the Classroom!" The volumes focus on: (1) "A Sampling of Renaissance Instruments," which includes: information on Christopher Columbus, Leondardo da Vinci, and William Shakespeare, a timeline from the middle ages through the renaissance, Queen…

  16. Bringing Breast Cancer Technologies to Market | Poster (United States)

    CCR research is recognized in novel competition to encourage the commercialization of breast cancer inventions. Editor’s note: This article was originally published in CCR Connections (Volume 8, No. 1). The Breast Cancer Startup Challenge was named one of six finalists in the HHS Innovates Award Competition, and was one of three finalists recognized by HHS Secretary Sylvia Mathews Burwell and Deputy Secretary Bill Corr. For more information on the Challenge, see previous article on the Poster website. Start-up companies are instrumental in bringing the fruits of scientific research to market. Recognizing an opportunity to bring entrepreneurial minds to bear on the diagnosis and treatment of breast cancer, the Avon Foundation for Women partnered with NCI and the Center for Advancing Innovation to launch the Breast Cancer Startup Challenge.

  17. Editorial: Biotechnology Journal brings more than biotechnology. (United States)

    Jungbauer, Alois; Lee, Sang Yup


    Biotechnology Journal always brings the state-of-the-art biotechnologies to our readers. Different from other topical issues, this issue of Biotechnology Journal is complied with a series of exiting reviews and research articles from spontaneous submissions, again, addressing society's actual problems and needs. The progress is a real testimony how biotechnology contributes to achievements in healthcare, better utilization of resources, and a bio-based economy. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Bringing Advanced Computational Techniques to Energy Research

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Julie C


    Please find attached our final technical report for the BACTER Institute award. BACTER was created as a graduate and postdoctoral training program for the advancement of computational biology applied to questions of relevance to bioenergy research.

  19. Bringing Pulsed Laser Welding into Production

    DEFF Research Database (Denmark)

    Olsen, Flemmming Ove


    In this paper, some research and develop-ment activities within pulsed laser welding technology at the Tech-nical University of Denmark will be described. The laser group at the Insti-tute for Manufacturing Technology has nearly 20 years of experience in laser materials process-ing. Inter......-nationally the group is mostly known for its contri-butions to the development of the laser cutting process, but further it has been active within laser welding, both in assisting industry in bringing laser welding into production in several cases and in performing fundamental R & D. In this paper some research...... activities concerning the weldability of high alloyed austenitic stainless steels for mass production industry applying industrial lasers for fine welding will be described. Studies on hot cracking sensitivity of high alloyed austenitic stainless steel applying both ND-YAG-lasers and CO2-lasers has been...

  20. DNA nanotechnology: Bringing lipid bilayers into shape (United States)

    Howorka, Stefan


    Lipid bilayers form the thin and floppy membranes that define the boundary of compartments such as cells. Now, a method to control the shape and size of bilayers using DNA nanoscaffolds has been developed. Such designer materials advance synthetic biology and could find use in membrane research.

  1. Bringing Exoplanet Habitability Investigations to High School (United States)

    Woody, Mary Anne; Sohl, Linda


    Habitability, a.k.a. habitat suitability, is a topic typically discussed in Biology class. We present here a curriculum unit that introduces the topic of global-scale planetary habitability in a Physics classroom, allowing students to emulate the process of doing cutting-edge science and re-framing an otherwise "typical" physics unit in a more engaging and interactive way.

  2. Bringing science to the policy table

    CERN Multimedia


    “They shall beat their swords into plowshares, and their spears into pruning hooks. Nation shall not lift up sword against nation. Neither shall they learn war anymore." So says Isaiah 2:4, as transcribed on the famous wall in Ralph Bunche park, just the other side of 1st Avenue from the UN’s New York headquarters, where we held a celebration of our 60th anniversary year on Monday 20 October. I used the quotation in my opening address, since it is such a perfect fit to the theme of 60 years of science for peace and development.   The event was organised with the United Nations Economic and Social Council, ECOSOC, in the framework of CERN’s observer status at the UN, and although focused on CERN, its aim was broader. Presentations used CERN as an example to bring out the vital importance of science in general to the themes of peace and development. The event was presided over by Martin Sajdik, President of ECOSOC, and we were privileged to have presentat...

  3. Poster power brings together electronics community

    CERN Multimedia


    An 'Electronics at CERN' poster session was displayed on the mezzanine in building 500 for two days from 30 November. The display consisted of 20 posters and brought together a wide range of electronic projects designed and assembled by CERN teams and other collaborators involved in the building of the LHC. This was the first time this event had been held. As its organiser John Evans (IT/DES) explained, 'the idea came from the experience of attending conferences outside CERN, where you may find projects from CERN you didn't know about. It's nice to bring them together so we can all benefit from the efforts made.' The work on show spanned different departments and experiments, ranging from microelectronics to equipment designed for giant magnets. The invited audience was equally broad and included engineers, physicists as well as the electronics community at CERN. An informal gathering of all the exhibitors also offered an opportunity to view and discuss the work over a cup of coffee. 'The poster session acts...

  4. Bringing mask repair to the next level (United States)

    Edinger, K.; Wolff, K.; Steigerwald, H.; Auth, N.; Spies, P.; Oster, J.; Schneider, H.; Budach, M.; Hofmann, T.; Waiblinger, M.


    Mask repair is an essential step in the mask manufacturing process as the extension of 193nm technology and the insertion of EUV are drivers for mask complexity and cost. The ability to repair all types of defects on all mask blank materials is crucial for the economic success of a mask shop operation. In the future mask repair is facing several challenges. The mask minimum features sizes are shrinking and require a higher resolution repair tool. At the same time mask blanks with different new mask materials are introduced to optimize optical performance and long term durability. For EUV masks new classes of defects like multilayer and phase defects are entering the stage. In order to achieve a high yield, mask repair has to cover etch and deposition capabilities and must not damage the mask. These challenges require sophisticated technologies to bring mask repair to the next level. For high end masks ion-beam based and e-based repair technologies are the obvious choice when it comes to the repair of small features. Both technologies have their pro and cons. The scope of this paper is to review and compare the performance of ion-beam based mask repair to e-beam based mask repair. We will analyze the limits of both technologies theoretically and experimentally and show mask repair related performance data. Based on this data, we will give an outlook to future mask repair tools.

  5. Bring NASA Scientific Data into GIS (United States)

    Xu, H.


    NASA's Earth Observation System (EOS) and many other missions produce data of huge volume and near real time which drives the research and understanding of climate change. Geographic Information System (GIS) is a technology used for the management, visualization and analysis of spatial data. Since it's inception in the 1960s, GIS has been applied to many fields at the city, state, national, and world scales. People continue to use it today to analyze and visualize trends, patterns, and relationships from the massive datasets of scientific data. There is great interest in both the scientific and GIS communities in improving technologies that can bring scientific data into a GIS environment, where scientific research and analysis can be shared through the GIS platform to the public. Most NASA scientific data are delivered in the Hierarchical Data Format (HDF), a format is both flexible and powerful. However, this flexibility results in challenges when trying to develop supported GIS software - data stored with HDF formats lack a unified standard and convention among these products. The presentation introduces an information model that enables ArcGIS software to ingest NASA scientific data and create a multidimensional raster - univariate and multivariate hypercubes - for scientific visualization and analysis. We will present the framework how ArcGIS leverages the open source GDAL (Geospatial Data Abstract Library) to support its raster data access, discuss how we overcame the GDAL drivers limitations in handing scientific products that are stored with HDF4 and HDF5 formats and how we improve the way in modeling the multidimensionality with GDAL. In additional, we will talk about the direction of ArcGIS handling NASA products and demonstrate how the multidimensional information model can help scientists work with various data products such as MODIS, MOPPIT, SMAP as well as many data products in a GIS environment.

  6. Bringing nature-based solutions to scale (United States)

    Jongman, Brenden; Lange, Glenn-Marie; Balog, Simone; van Wesenbeeck, Bregje


    Coastal communities in developing countries are highly exposed and vulnerable to coastal flood risk, and are likely to suffer from climate change induced changes in risk. Over the last decade, strong evidence has surfaced that nature-based solutions or ecosystem-based approaches are efficient and effective alternatives for flood risk reduction and climate change adaptation. In developing countries, numerous projects have therefore been implemented, often driven by international donors and NGOs. Some of these projects have been successful in reducing risk while improving environmental and socioeconomic conditions. However, the feasibility assessment, design and implementation of nature-based solutions is a multifaceted process, which needs to be well-understood before such solutions can be effectively implemented as an addition or alternative to grey infrastructure. This process has not always been followed. As a result, many projects have failed to deliver positive outcomes. The international community therefore has a challenge in bringing nature-based solutions to scale in an effective way. In this presentation, we will present best practice guidelines on nature-based solution implementation that are currently being discussed by the international community. Furthermore, we will present the alpha version of a new web platform being developed by the World Bank that will serve as a much-needed central repository for project information on nature-based solutions, and that will host actionable implementation guidelines. The presentation will also serve as an invitation to the scientific community to share their experience and lessons learned, and contribute to the outlining of best practice guidance.

  7. Bringing the Unidata IDV to the Cloud (United States)

    Fisher, W. I.; Oxelson Ganter, J.


    Maintaining software compatibility across new computing environments and the associated underlying hardware is a common problem for software engineers and scientific programmers. While traditional software engineering provides a suite of tools and methodologies which may mitigate this issue, they are typically ignored by developers lacking a background in software engineering. Causing further problems, these methodologies are best applied at the start of project; trying to apply them to an existing, mature project can require an immense effort. Visualization software is particularly vulnerable to this problem, given the inherent dependency on particular graphics hardware and software API's. As a result of these issues, there exists a large body of software which is simultaneously critical to the scientists who are dependent upon it, and yet increasingly difficult to maintain.The solution to this problem was partially provided with the advent of Cloud Computing; Application Streaming. This technology allows a program to run entirely on a remote virtual machine while still allowing for interactivity and dynamic visualizations, with little-to-no re-engineering required. When coupled with containerization technology such as Docker, we are able to easily bring the same visualization software to a desktop, a netbook, a smartphone, and the next generation of hardware, whatever it may be.Unidata has been able to harness Application Streaming to provide a tablet-compatible version of our visualization software, the Integrated Data Viewer (IDV). This work will examine the challenges associated with adapting the IDV to an application streaming platform, and include a brief discussion of the underlying technologies involved.

  8. Bringing Artificial Gravity into the Classroom (United States)

    Thompson, Grant; Aning, Isaac


    We recently conducted an experimental test of artificial gravity by placing various species of plants in centrifuges and analyzed the plants’ germination and growth. This research project incorporated several topics covered in undergraduate astronomy, biology, and physics courses. Given the interest of introductory astronomy students in artificial gravity and their pre-existing images of applications such as rotating spacecraft from pop culture, the results of the experiment may provide a gateway to discuss artificial gravity beyond teaching the traditional examples of Newton’s laws. We will discuss the experiment in detail and provide suggestions for how the experiment could be incorporated into your classroom.

  9. Has Modern Biology Entered the Mouth? The Clinical Impact of Biological Research. (United States)

    Baum, Bruce J.


    Three areas of biological research that are beginning to have an impact on clinical medicine are examined, including molecular biology, cell biology, and biotechnology. It is concluded that oral biologists and educators must work cooperatively to bring rapid biological and biomedical advances into dental training in a meaningful way. (MSE)

  10. How epigenomics brings phenotype into being. (United States)

    Martín-Subero, Jose Ignacio


    After sequencing the human genome, it has become clear that genetic information alone is not sufficient to understand phenotypic manifestations. The way the DNA code is translated into function depends not only on its sequence but also on the interaction with environmental factors. It is in this intersection where the science of epigenetics plays a crucial role. Epigenetic mechanisms like DNA methylation and histone modifications are essential for multiple physiological processes like development, establishment of tissue identity, imprinting, X-chromosome inactivation, chromosomal stability and gene transcription regulation. Additionally, environmental factors like nutrition or maternal behavior in early childhood are able to induce epigenetic changes. This short review aims at summarizing the role of epigenetics in multiple aspects of biology and medicine, including development, cancer, non-tumoral diseases, environmentally induced phenotypic changes, and also in inheritance and evolution.

  11. EarthObserver: Bringing the world to your fingertips (United States)

    Ryan, W. B.; Goodwillie, A. M.; Coplan, J.; Carbotte, S. M.; Arko, R. A.; Ferrini, V.; O'hara, S. H.; Chan, S.; Bonczkowski, J.; Nitsche, F. O.; Morton, J. J.; McLain, K.; Weissel, R.


    EarthObserver (, developed by the Lamont-Doherty Earth Observatory of Columbia University, brings a wealth of geoscience data to Apple iPad, iPhone and iPod Touch mobile devices. Built around an easy-to-use interface, EarthObserver allows users to explore and visualise a wide range of data sets superimposed upon a detailed base map of land elevations and ocean depths - tapping the screen will instantly return the height or depth at that point. A simple transparency function allows direct comparison of built-in content. Data sets include high-resolution coastal bathymetry of bays, sounds, estuaries, harbors and rivers; geological maps of the US states and world - tapping the screen displays the rock type, and full legends can be viewed; US Topo sheets; and, geophysical content including seafloor crustal age and sediment thickness, earthquake and volcano data, gravity and magnetic anomalies, and plate boundary descriptions. The names of physiographic features are automatically displayed. NASA Visible Earth images along with ocean temperature, salinity and productivity maps and precipitation information expose data sets of interest to the atmospheric, oceanic and biological communities. Natural hazard maps, population information and political boundaries allow users to explore impacts upon society. EarthObserver, so far downloaded by more than 55,000 users, offers myriad ways for educators at all levels to bring research-quality geoscience data into the learning environment, whether for use as an in-class illustration or for extensive exploration of earth sciences data. By using cutting-edge mobile app technology, EarthObserver boosts access to relevant earth science content. The EarthObserver base map is the Global Multi-Resolution Topography digital elevation model (GMRT;, also developed at LDEO and updated regularly. It provides land elevations with horizontal resolution as high as 10m for

  12. Bringing computational science to the public. (United States)

    McDonagh, James L; Barker, Daniel; Alderson, Rosanna G


    The increasing use of computers in science allows for the scientific analyses of large datasets at an increasing pace. We provided examples and interactive demonstrations at Dundee Science Centre as part of the 2015 Women in Science festival, to present aspects of computational science to the general public. We used low-cost Raspberry Pi computers to provide hands on experience in computer programming and demonstrated the application of computers to biology. Computer games were used as a means to introduce computers to younger visitors. The success of the event was evaluated by voluntary feedback forms completed by visitors, in conjunction with our own self-evaluation. This work builds on the original work of the 4273π bioinformatics education program of Barker et al. (2013, BMC Bioinform. 14:243). 4273π provides open source education materials in bioinformatics. This work looks at the potential to adapt similar materials for public engagement events. It appears, at least in our small sample of visitors (n = 13), that basic computational science can be conveyed to people of all ages by means of interactive demonstrations. Children as young as five were able to successfully edit simple computer programs with supervision. This was, in many cases, their first experience of computer programming. The feedback is predominantly positive, showing strong support for improving computational science education, but also included suggestions for improvement. Our conclusions are necessarily preliminary. However, feedback forms suggest methods were generally well received among the participants; "Easy to follow. Clear explanation" and "Very easy. Demonstrators were very informative." Our event, held at a local Science Centre in Dundee, demonstrates that computer games and programming activities suitable for young children can be performed alongside a more specialised and applied introduction to computational science for older visitors.

  13. Bringing Water into an Integrated Assessment Framework

    Energy Technology Data Exchange (ETDEWEB)

    Izaurralde, Roberto C.; Thomson, Allison M.; Sands, Ronald; Pitcher, Hugh M.


    We developed a modeling capability to understand how water is allocated within a river basin and examined present and future water allocations among agriculture, energy production, other human requirements, and ecological needs. Water is an essential natural resource needed for food and fiber production, household and industrial uses, energy production, transportation, tourism and recreation, and the functioning of natural ecosystems. Anthropogenic climate change and population growth are anticipated to impose unprecedented pressure on water resources during this century. Pacific Northwest National Laboratory (PNNL) researchers have pioneered the development of integrated assessment (IA) models for the analysis of energy and economic systems under conditions of climate change. This Laboratory Directed Research and Development (LDRD) effort led to the development of a modeling capability to evaluate current and future water allocations between human requirements and ecosystem services. The Water Prototype Model (WPM) was built in STELLA®, a computer modeling package with a powerful interface that enables users to construct dynamic models to simulate and integrate many processes (biological, hydrological, economics, sociological). A 150,404-km2 basin in the United States (U.S.) Pacific Northwest region served as the platform for the development of the WPM. About 60% of the study basin is in the state of Washington with the rest in Oregon. The Columbia River runs through the basin for 874 km, starting at the international border with Canada and ending (for the purpose of the simulation) at The Dalles dam. Water enters the basin through precipitation and from streamflows originating from the Columbia River at the international border with Canada, the Spokane River, and the Snake River. Water leaves the basin through evapotranspiration, consumptive uses (irrigation, livestock, domestic, commercial, mining, industrial, and off-stream power generation), and streamflow

  14. Bring your own device (BYOD) to work trend report

    CERN Document Server

    Hayes, Bob


    Bring Your Own Device (BYOD) to Work examines the emerging BYOD (Bring Your Own Device to work) trend in corporate IT. BYOD is the practice of employees bringing personally-owned mobile devices (e.g., smartphones, tablets, laptops) to the workplace, and using those devices to access company resources such as email, file servers, and databases. BYOD presents unique challenges in data privacy, confidentiality, security, productivity, and acceptable use that must be met proactively by information security professionals. This report provides solid background on the practice, original res

  15. Can Smartphone Use Bring on Carpal Tunnel Syndrome? (United States)

    ... Can Smartphone Use Bring on Carpal Tunnel Syndrome? Maybe, especially ... People who spend lots of time on their smartphones may be scrolling, tapping and swiping their way ...

  16. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia


    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  17. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia


    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  18. What to bring to your labor and delivery (United States)

    Prenatal care - what to bring ... underwear, and basic toiletries. While it is nice to have your own clothes with you, labor and ... very messy time, so you may not want to wear your brand-new lingerie. Items you should ...

  19. Practical ways of bringing innovations and creativity into the school ...

    African Journals Online (AJOL)

    This article describes the practical ways of bringing innovations and creativity into the school library media programme in Nigeria. Discussion focused on areas on creativity and innovations such as environmental design, staffing, outreach activities, library cooperation, and introduction of ICT system. Keywords: Innovations ...

  20. Bring Your Own Device: Parental Guidance (PG) Suggested (United States)

    Kiger, Derick; Herro, Dani


    Educators are incorporating students' mobile devices into the schooling experience via Bring Your Own Device (BYOD) initiatives. This is advantageous for many reasons, most notably, improving access to Internet resources and digital tools in support of teaching and learning. Obtaining parental support is key to BYOD success. Therefore, this study…

  1. "Bring Your Own Device": Considering Potential Risks to Student Health (United States)

    Merga, Margaret K.


    Background and context: Schools in Australia and internationally are increasingly adopting a Bring Your Own Device (BYOD) approach to teaching and learning. The review: While discussion of a BYOD approach has taken place, there is a dearth of consideration of the potential impact of BYOD policy on student health. Implementation of a BYOD policy…

  2. Bringing climate change into natural resource management: proceedings. (United States)

    L. Joyce; R. Haynes; R. White; R.J. Barbour


    These are the proceedings of the 2005 workshop titled implications of bringing climate into natural resource management in the Western United States. This workshop was an attempt to further the dialogue among scientists, land managers, landowners, interested stakeholders and the public about how individuals are addressing climate change in natural resource management....

  3. High School Academies Bring Inner-City Youth into Mainstream. (United States)

    Koning, Hendrik B.


    Describes the Philadelphia High School Academies, vocational schools in the inner city that are jointly operated and funded by the public schools and local business and labor leaders. Discusses the program's growth and the reasons for its success in bringing inner city youth into the mainstream. (JOW)

  4. CASE STUDY: Vietnam — Information brings progress to Vietnam's ...

    International Development Research Centre (IDRC) Digital Library (Canada)


    CASE STUDY: Vietnam — Information brings progress to Vietnam's communes. December 16, 2010. Image. Michelle Hibler. In Vietnam, a .... The strategy, he says, is to concentrate assistance on vulnerable groups, like women-headed households, widows, and invalids. There are 41 such deprived households in Gia Son.

  5. Model Testing - Bringing the Ocean into the Laboratory

    DEFF Research Database (Denmark)

    Aage, Christian


    Hydrodynamic model testing, the principle of bringing the ocean into the laboratory to study the behaviour of the ocean itself and the response of man-made structures in the ocean in reduced scale, has been known for centuries. Due to an insufficient understanding of the physics involved, however...

  6. Bringing Critical Thinking to the Education of Developing Country Professionals (United States)

    Richmond, Jonathan E. D.


    Cultural differences between Asia and the West and their influence on teaching, are reviewed along with previous experiments in bringing critical thinking to Asian education, and recognition of needs for and barriers to achieving change. Principles driving design and implementation of a two-course sequence in professional transportation studies…

  7. Bringing Curriculum Theory and Didactics Together: A Deweyan Perspective (United States)

    Deng, Zongyi


    Using Dewey's method of resolution for resolving a dualism exemplified in "The Child and the Curriculum," this article reconciles and brings together two rival schools of thought--curriculum theory and didactics--in China. The central thesis is that the rapprochement requires a reconceptualisation of curriculum theory and didactics in…

  8. Bringing the LHC and ATLAS to a regional planetarium

    CERN Document Server

    Schwienhorst, Reinhard


    An outreach effort has started at Michigan State University to bring particle physics, the Large Hadron Collider, and the ATLAS experiment to a general audience at the Abrams planetarium on the MSU campus. A team of undergraduate students majoring in physics, communications arts & sciences, and journalism are putting together short clips about ATLAS and the LHC to be shown at the planetarium.

  9. Bringing golf into sport psychology sessions through technology ...

    African Journals Online (AJOL)

    Bringing golf into sport psychology sessions through technology (video footage) ... sessions through technology (video footage). L Human, D Kriek, T Bezuidenhout ... psychology sessions informed by narrative practice with the six golfers respectively, during which the identified material from Stage 2 was discussed. During ...

  10. Bringing connectivity to rural Zambia using a collaborative approach

    CSIR Research Space (South Africa)

    Matthee, K


    Full Text Available This paper presents an initiative to bring connectivity to rural Zambia using a collaborative approach. In particular, it focuses on a proof-of-concept Internet service that has been implemented in rural Macha located in the Southern Province...

  11. Bringing Foreign Language Learning into the 21st century | Thomas ...

    African Journals Online (AJOL)

    Bringing Foreign Language Learning into the 21st Century. The different challenges facing foreign language lecturers are considered as well as the different methods used to teach a foreign language. Technology and multimedia are proposed not only as tools and supports but also as a possible solution. With the change ...

  12. The Protein Data Bank in Europe (PDBe): bringing structure to biology

    Energy Technology Data Exchange (ETDEWEB)

    Velankar, Sameer; Kleywegt, Gerard J., E-mail: [Protein Data Bank in Europe (PDBe), EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD (United Kingdom)


    Some future challenges for the PDB and its guardians are discussed and current and future activities in structural bioinformatics at the Protein Data Bank in Europe (PDBe) are described. The Protein Data Bank in Europe (PDBe) is the European partner in the Worldwide PDB and as such handles depositions of X-ray, NMR and EM data and structure models. PDBe also provides advanced bioinformatics services based on data from the PDB and related resources. Some of the challenges facing the PDB and its guardians are discussed, as well as some of the areas on which PDBe activities will focus in the future (advanced services, ligands, integration, validation and experimental data). Finally, some recent developments at PDBe are described.

  13. Bringing Biology Back In: The Unresolved Issue of “Epigenesis” in Kant

    Directory of Open Access Journals (Sweden)

    John H. Zammito


    Full Text Available Epigenesis has become a far more exciting issue in Kant studies recently, especially with the publication of Jennifer Mensch’s Kant’ Organicism. In my commentary, I propose to clarify my own position on epigenesis relative to that of Mensch by once again considering the discourse of epigenesis in the wider eighteenth century. In order to situate more precisely what Kant made of it in his own thought, I distinguish the metaphysical use Kant made of epigenesis from his rejection of its aptness as a theory for life science. In that light, I raise questions about the scope and authority of philosophy vis à vis natural science.

  14. Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques (United States)

    Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E.


    Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…

  15. ET versus Alien : Popular Attitudes to bringing back Biological Material from Space (United States)

    Evans, D.

    The general public tend to react to radical scientific innovation in extreme ways, seeing them alternatively as a passport to utopia or a ticket to hell. The possible discovery of alien life forms has generated both types of reaction, as a brief survey of Hollywood movies shows. In this fanciful world, alens are either the friendly beings of ET and Close Encounters, who show us a way to improve ourselves, or the frightening monsters of Alien and Independence Day, who are bent on our destruction. Yet most astrobiologists would agree that both types of scenario are extremely unlikely. If we do encounter other life forms, the scientific consensus is that such life is vastly more likely to be microbial than to be an advanced, intelligent multicellular species. The public focus on the improbable stories of Hollywood means that they are little prepared to engage in sensible dialogue about plans for sample return missions from Mars and other planets. Unless scientific organisations take steps to encourage a more realistic understanding of the kinds of life we are most likely to encounter in space, we risk seeing public debate on these matters degenerate into the same hysteria and idiocy as that which has surrounded the use of GM foods and stem cell research.

  16. Beyond the Cell: Using Multiscalar Topics to Bring Interdisciplinarity into Undergraduate Cellular Biology Courses (United States)

    Weber, Carolyn F.


    Western science has grown increasingly reductionistic and, in parallel, the undergraduate life sciences curriculum has become disciplinarily fragmented. While reductionistic approaches have led to landmark discoveries, many of the most exciting scientific advances in the late 20th century have occurred at disciplinary interfaces; work at these…

  17. A Proposal for Measuring Interactivity that Brings Learning Effectiveness

    Directory of Open Access Journals (Sweden)

    Tosh Yamamoto


    Full Text Available It is proposed in this paper that some type of way to measure and visualize interactivity in the multimedia or e-Learning contents is necessary in order to clearly identify interactivity that brings learning effectiveness. Interactivity during learning will arouse students’ intellectual curiosity and motivate them to learn further. Although the interaction in the communication between the teacher and his/her students in a regular classroom is ideal, it is not possible to maintain the equivalence in the multimedia or e-Learning contents. In order to rigorously formalize the field of measuring interactivity as a theory, theoretical constructs such as interactivity, interest, knowledge, and experience are redefined first. Then, the defined “interactivity” is broken down to subcomponents to develop an assessment tool for the interactivity which brings learning effectiveness. In the end, it is proved that the interactivity in learning can be measured.

  18. Befriending Everyday Life When Bringing Technology Into the Private Sphere. (United States)

    Lindberg, Catharina; Fagerström, Cecilia; Willman, Ania; Sivberg, Bengt


    We present the findings of our phenomenological interview study concerning the meaning of being an autonomous person while dependent on advanced medical technology at home. This was elucidated in the participants' narratives as befriending everyday life when bringing technology into the private sphere. We discovered four constituents of the phenomenon: befriending the lived body, depending on good relationships, keeping the home as a private sphere, and managing time. The most important finding was the overall position of the lived body by means of the illness limiting the control over one's life. We found that the participants wanted to be involved in and have influence over their care to be able to enjoy autonomy. We therefore stress the importance of bringing the patients into the care process as chronic illness will be a part of their everyday life for a long time to come, hence challenging patient autonomy.

  19. Framework for Bringing Data Streams to the Grid

    Directory of Open Access Journals (Sweden)

    Beth Plale


    Full Text Available Data streams are a prevalent and growing source of timely data, particularly in the scientific domain. Just as it is common today to read starting conditions such as initial weather conditions, for a scientific simulation from a file, it should be equally as easy to draw starting conditions on-demand from live data streams. But efforts to date to bring streaming data to the grid have lacked generality. In this article we introduce a new model for bringing existing data streams systems onto the grid. The model is predicated on the ability to identify stream systems that meet the criteria of being a "data resource". We establish the criteria in this article, and define a grid service architecture for a data streams resource that leverages standardization efforts in the Global Grid Forum. We discuss key research issues in realizing the data streams model. We are currently developing a prototype of this architecture using our dQUOB system.

  20. Foreign Aided: Why Democratization Brings Growth When Democracy Does Not

    DEFF Research Database (Denmark)

    Hariri, Jacob Gerner


    There is an unresolved puzzle in research on the economics of democracy. While there is consensus that democracy is not generally associated with higher rates of economic growth, recent studies have found that democratization is followed by growth. But why should becoming a democracy bring growth...... if being one does not? This article shows that a substantial and immediate influx of foreign aid into new democracies accounts for the positive growth effect of democratization. The domestic regime characteristics of neither democracy nor democratization therefore seems to bring growth. The importance...... of aid in explaining the democratization-growth nexus underscores that democratizations do not occur in vacuum and cannot be fully understood from internal factors alone...

  1. MANU Building – Bringing together Manufacturing Automation and Building Automation


    Bratukhin, Aleksey; Treytl, Albert; Sauter, Thilo


    Part IV: ICT and Emerging Technologies in Production Management; International audience; Up to now, production systems only concern was to minimize production costs or optimize the utilization of production resources. But with the increasing energy prices and the growing concern over the environmental impact of production systems (industrial systems consume a quarter of all energy), efficient use of energy in manufacturing environment cannot be ignored any longer.MANUbuilding concept brings t...

  2. [Psychological features of mothers bringing up disabled children]. (United States)

    Kocherova, O Iu; Fil'kina, O M; Dolotova, N V; Malyshkina, A I; Antysheva, E N


    Research objective was to define psychological makers of mothers bringing up disabled children for scientific justification of the family psychotherapy branches. 60 mothers bringing up children of early age with infantile cerebral palsy and 50 mothers of children with compensation of perinatal affections of the central nervous system by the 1 life year are surveyed. Personal characteristics, family orientations of mothers, child and mother relations, awareness of mothers on the children health state and the attitude to their rehabilitation were studied by means of psychological techniques. It is found out that the mothers bringing up disabled children more often have emotional disorders, negative attitude to divorce and give the leading role in a family to the husband less often they show hypoguardianship of the child than the mothers of children with compensation of perinatal affections of the central nervous system. Mothers are less satisfied with the child development, they are more often worried about disorders of development of movements, speech and mental development delay, small appetite of the child, they feel helplessness in rehabilitation more often, note the ambiguity of its prospects. They understand that their child needs the help of the qualified experts: neurologist, orthopaedist, logopedist, psychologist, but they aren't satisfied with communication with them more often, underestimate own role in rehabilitation. The revealed characteristics prove the necessity and define the main directions of family psychotherapy--correction of mother's emotional disorders, child and parental relations, increase of medical and psychological competence that allows to increase efficiency of rehabilitation.

  3. High performance bioinformatics and computational biology on general-purpose graphics processing units


    Ling, Cheng


    Bioinformatics and Computational Biology (BCB) is a relatively new multidisciplinary field which brings together many aspects of the fields of biology, computer science, statistics, and engineering. Bioinformatics extracts useful information from biological data and makes these more intuitive and understandable by applying principles of information sciences, while computational biology harnesses computational approaches and technologies to answer biological questions conveni...

  4. Nanotechnology for biology and medicine at the building block level

    CERN Document Server

    Silva, Gabriel A


    This text book will bring together a mix of both internationally known and established senior scientists along side up and coming (but already accomplished) junior scientists that have varying expertise in fundamental and applied nanotechnology to biology and medicine.

  5. International Career Development in Education: What Teachers Bring Home

    Directory of Open Access Journals (Sweden)

    Mustafa Altun


    Full Text Available Working abroad helps teachers have a global perspective and enable them to become aware of global affairs. Teachers with international experience stands a better chance for professional and personal development. They not only enhance their teaching skills but also become more social. The skills they develop while working abroad make a difference in the lives of their students. Through transferring what they have learnt abroad to their home country, they can enhance the success of their students. This article presents the reasons why teachers need international experience and what changes they bring home.

  6. Bring Your Own Device - Providing Reliable Model of Data Access

    Directory of Open Access Journals (Sweden)

    Stąpór Paweł


    Full Text Available The article presents a model of Bring Your Own Device (BYOD as a model network, which provides the user reliable access to network resources. BYOD is a model dynamically developing, which can be applied in many areas. Research network has been launched in order to carry out the test, in which as a service of BYOD model Work Folders service was used. This service allows the user to synchronize files between the device and the server. An access to the network is completed through the wireless communication by the 802.11n standard. Obtained results are shown and analyzed in this article.

  7. The Napping Company: bringing science to the workplace. (United States)

    Anthony, William A; Anthony, Camille W


    Increasing emphasis is currently being given to the importance of bringing knowledge gained from science into places where people live and work, in order to increase the impact science has on the general public's quality of life. Scientific findings about the positive impact of napping on mood and performance are an example of research generated knowledge that needs to be brought to the workplace. A major goal of the Napping Company ( is to bring the science of napping to the workers and the workplace so that employees and employers can act on this knowledge and change worker napping behavior and employer napping policies. The present paper overviews the challenges inherent in making scientific knowledge useful to how we live our lives. The Napping Company is guided by five principles of knowledge transfer in the company's attempts to disseminate and increase utilization of napping research. Examples are given to illustrate how the Napping Company has used these principles to bridge the gap between napping science and nap behavior and policies in the workplace.

  8. A Review of Bring Your Own Device on Security Issues

    Directory of Open Access Journals (Sweden)

    Morufu Olalere


    Full Text Available Mobile computing has supplanted internet computing because of the proliferation of cloud-based applications and mobile devices (such as smartphones, palmtops, and tablets. As a result of this, workers bring their mobile devices to the workplace and use them for enterprise work. The policy of allowing the employees to work with their own personal mobile devices is called Bring Your Own Devices (BYOD. In this article, we discuss BYOD’s background, prevalence, benefits, challenges, and possible security attacks. We then review contributions of academic researchers on BYOD. The Universiti Putra Malaysia online databases (such as IEEE Xplore digital library, Elsevier, Springer, ACM digital library were used to search for peer-reviewed academic publications and other relevant publications on BYOD. The Google Scholar search engine was also used. Our thorough review shows that security issues comprise the most significant challenge confronting BYOD policy and that very little has been done to tackle this security challenge. It is our hope that this review will provide a theoretical background for future research and enable researchers to identify researchable areas of BYOD.

  9. Biological drivers of zooplankton patchiness. (United States)

    Folt; Burns


    Until recently, biological drivers of plankton aggregation were under-appreciated, because most studies concentrated on physical processes. New technological advances, novel experiments and theory have shifted focus to the pivotal role of behaviour in plankton patch dynamics. Our review highlights four biological drivers of zooplankton spatial patchiness and brings together recent research on well studied marine and freshwater taxa, primarily copepods and cladocerans. Diverse and powerful behavioural responses by zooplankton to physical and chemical signals are shown to contribute to the formation and breakdown of zooplankton patches over several different spatial scales.

  10. Do Daughters Bring Out a Dad's 'Softer Side'? (United States)

    ... explanations. Makeba Parramore Wilbourn, an assistant professor of psychology and neuroscience at Duke University in Durham, N.C., said cultural influences rather than biology probably underpin the way fathers behaved. "Though we ...

  11. Bringing Technology in Line with the Natural Laws. (United States)

    Clark, Mary E.


    Biology teachers can provide lessons for students to help them plan the future wisely. Three natural laws are emphasized as imperative to understanding how to plan wisely for restoring a balance in nature. (SA)

  12. Systems biology and cardiac arrhythmias. (United States)

    Grace, Andrew A; Roden, Dan M


    During the past few years, the development of effective, empirical technologies for treatment of cardiac arrhythmias has exceeded the pace at which detailed knowledge of the underlying biology has accumulated. As a result, although some clinical arrhythmias can be cured with techniques such as catheter ablation, drug treatment and prediction of the risk of sudden death remain fairly primitive. The identification of key candidate genes for monogenic arrhythmia syndromes shows that to bring basic biology to the clinic is a powerful approach. Increasingly sophisticated experimental models and methods of measurement, including stem cell-based models of human cardiac arrhythmias, are being deployed to study how perturbations in several biologic pathways can result in an arrhythmia-prone heart. The biology of arrhythmia is largely quantifiable, which allows for systematic analysis that could transform treatment strategies that are often still empirical into management based on molecular evidence. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Biological computation

    CERN Document Server

    Lamm, Ehud


    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  14. Bringing indigenous ownership back to the private sector

    DEFF Research Database (Denmark)

    Kragelund, Peter

    to traditional Copperbelt rhetoric, have enforced a role as minority middlemen upon the Chinese investors. This further segregates Chinese investors from other investors and has been a driving force in the anti-Chinese campaign in Zambia. To curb the critique of the growing foreign dominance over the economy......Driven by across-the-board liberalizations and the commodity price boom, Zambia has recently experienced an upsurge in foreign ownership over key parts of its economy. Albeit investors from all over the world have sought to make the most of the current situation in Zambia, Chinese investors have...... been particularly present in all sectors of the Zambian economy. Foreign ownership, however, is not new to African societies and several African countries pursued indigenisation policies in the wake of independence to bring ownership back to their own citizens. Now indigenisation policies thrive again...

  15. Archaeopteryx: Bringing the Dino-Bird to Life

    Energy Technology Data Exchange (ETDEWEB)

    Bergmann, Uwe


    Some 150 million years ago, a strange creature died in a tropical lagoon that today is located in Bavaria, Germany. In 1861, a single feather of this creature was discovered. Not long afterward, a complete fossil was found with the same bird-like feathers but dinosaur-like anatomical features. Darwin had just published 'On the Origin of Species'; could this be the missing link that Darwin's supporters hoped to find? Recently, two of the now eleven discovered Archaeopteryx fossils, and that first feather, were brought to SLAC, where, using the intense X-ray beam, researchers searched for the chemical remains of the original living creatures. Please join us for this lecture, which will explain how the studies attempt to bring the original dino-bird back to life.

  16. Bringing the power of dynamic languages to hardware control systems

    CERN Document Server

    Caicedo, J M; Neufeld, N


    Hardware control systems are normally programmed using high-performance languages like C or C++ and increasingly also Java. All these languages are strongly typed and compiled which brings usually good performance but at the cost of a longer development and testing cycle and the need for more programming expertise. Dynamic languages which were long thought to be too slow and not powerful enough for control purposes are, thanks to modern powerful computers and advanced implementation techniques, fast enough for many of these tasks. We present examples from the LHCb Experiment Control System (ECS), which is based on a commercial SCADA software. We have successfully used Python to integrate hardware devices into the ECS. We present the necessary lightweight middle-ware we have developed, including examples for controlling hardware and software devices. We also discuss the development cycle, tools used and compare the effort to traditional solutions.

  17. Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. (United States)

    Canter, Peter H; Thomas, Howard; Ernst, Edzard


    Consumption of herbal medicines is widespread and increasing. Harvesting from the wild, the main source of raw material, is causing loss of genetic diversity and habitat destruction. Domestic cultivation is a viable alternative and offers the opportunity to overcome the problems that are inherent in herbal extracts: misidentification, genetic and phenotypic variability, extract variability and instability, toxic components and contaminants. The use of controlled environments can overcome cultivation difficulties and could be a means to manipulate phenotypic variation in bioactive compounds and toxins. Conventional plant-breeding methods can improve both agronomic and medicinal traits, and molecular marker assisted selection will be used increasingly. There has been significant progress in the use of tissue culture and genetic transformation to alter pathways for the biosynthesis of target metabolites. Obstacles to bringing medicinal plants into successful commercial cultivation include the difficulty of predicting which extracts will remain marketable and the likely market preference for what is seen as naturally sourced extracts.

  18. [Multimedia (visual collaboration) brings true nature of human life]. (United States)

    Tomita, N


    Videoconferencing system, high-quality visual collaboration, is bringing Multimedia into a society. Multimedia, high quality media such as TV broadcast, looks expensive because it requires broadband network with 100-200 Mpbs bandwidth or 3,700 analog telephone lines. However, thanks to the existing digital-line called N-ISDN (Narrow Integrated Service Digital Network) and PictureTel's audio/video compression technologies, it becomes far less expensive. N-ISDN provides 128 Kbps bandwidth, over twice wider than analog line. PictureTel's technology instantly compress audio/video signal into 1/1,000 in size. This means, with ISDN and PictureTel technology. Multimedia is materialized over even single ISDN line. This will allow doctor to remotely meet face-to-face with a medical specialist or patients to interview, conduct physical examinations, review records, and prescribe treatments. Bonding multiple ISDN lines will further improve video quality that enables remote surgery. Surgeon can perform an operation on internal organ by projecting motion video from Endoscope's CCD camera to large display monitor. Also, PictureTel provides advanced technologies of eliminating background noise generated by surgical knives or scalpels during surgery. This will allow sound of the breath or heartbeat be clearly transmitted to the remote site. Thus, Multimedia eliminates the barrier of distance, enabling people to be just at home, to be anywhere in the world, to undergo up-to-date medical treatment by expertise. This will reduce medical cost and allow people to live in the suburbs, in less pollution, closer to the nature. People will foster more open and collaborative environment by participating in local activities. Such community-oriented life-style will atone for mass consumption, materialistic economy in the past, then bring true happiness and welfare into our life after all.

  19. Synthetic Biology: Applications Come of Age


    Khalil, Ahmad S.; Collins, James J.


    Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will change our lives in the coming years, leading to cheaper drugs, “green” means to fuel our cars, and targeted therapies to attack “superbugs” and diseases such as cancer. The de novo engineering of genetic circuits, biological modules, and synthetic pathways is ...

  20. Biological drugs


    Bertrán Suárez, Marc


    Póster Biological drugs include a wide range of medicinal products created by biological instead of chemical processes. Biological drugs can consist of proteins, nucleic acids or complex combinations of substances, or may be living entities such as cells and tissues. They are isolated from natural sources or are produced by biotechnology methods.

  1. An Empathic Virtual Buddy for Social Support

    NARCIS (Netherlands)

    Van der Zwaan, J.M.


    Recent years have witnessed a growing interest in employing Embodied Conversational Agents (ECAs) as companions or coaches. These roles are typically performed by humans and require exhibiting certain social behaviors, such as providing social support. For interactions between users and coaching or

  2. EDITORIAL: Physical Biology (United States)

    Roscoe, Jane


    Physical Biology is a new peer-reviewed publication from Institute of Physics Publishing. Launched in 2004, the journal will foster the integration of biology with the traditionally more quantitative fields of physics, chemistry, computer science and other math-based disciplines. Its primary aim is to further the understanding of biological systems at all levels of complexity, ranging from the role of structure and dynamics of a single molecule to cellular networks and organisms. The journal encourages the development of a new biology-driven physics based on the extraordinary and increasingly rich data arising in biology, and provides research directions for those involved in the creation of novel bio-engineered systems. Physical Biology will publish a stimulating combination of full length research articles, communications, perspectives, reviews and tutorials from a wide range of disciplines covering topics such as: Single-molecule studies and nanobiotechnology Molecular interactions and protein folding Charge transfer and photobiology Ion channels; structure, function and ion regulation Molecular motors and force generation Subcellular processes Biological networks and neural systems Modeling aspects of molecular and cell biology Cell-cell signaling and interaction Biological patterns and development Evolutionary processes Novel tools and methods in physical biology Experts in the areas encompassed by the journal's scope have been appointed to the Editorial Scientific Committee and the composition of the Committee will be updated regularly to reflect the developments in this new and exciting field. Physical Biology is free online to everyone in 2004; you are invited to take advantage of this offer by visiting the journal homepage at This special print edition of Physical Biology is a combination of issues 1 and 2 of this electronic-only journal and it brings together an impressive range of articles in the fields covered, including a popular

  3. Mathematical biology

    CERN Document Server

    Murray, James D


    The book is a textbook (with many exercises) giving an in-depth account of the practical use of mathematical modelling in the biomedical sciences. The mathematical level required is generally not high and the emphasis is on what is required to solve the real biological problem. The subject matter is drawn, e.g. from population biology, reaction kinetics, biological oscillators and switches, Belousov-Zhabotinskii reaction, reaction-diffusion theory, biological wave phenomena, central pattern generators, neural models, spread of epidemics, mechanochemical theory of biological pattern formation and importance in evolution. Most of the models are based on real biological problems and the predictions and explanations offered as a direct result of mathematical analysis of the models are important aspects of the book. The aim is to provide a thorough training in practical mathematical biology and to show how exciting and novel mathematical challenges arise from a genuine interdisciplinary involvement with the biosci...

  4. A Modeling Approach to Teaching Evolutionary Biology in High Schools. (United States)

    Passmore, Cynthia; Stewart, Jim


    Describes the commitments and research that went into the design of a 9-week high school course in evolutionary biology designed to bring students to an understanding of the practice of evolutionary biology by engaging them in developing, elaborating, and using one of the discipline's most important explanatory models. (Contains 39 references.)…

  5. Using Augmented Reality to Bring interactivity to Metabolism Teaching

    Directory of Open Access Journals (Sweden)

    Galembeck E.


    Full Text Available INTRODUCTION: A glycolysis paper puzzle designed to introduce students to theprinciples of metabolic pathways have being used for several years, and it seems to helpstudents to learn the topic. We noticed that both the number of instructors and the timethey spend with the students, plays a major role in the success of the activity. Aninsufficient number of instructors do not permit adequate contact with all the students,which frustrate and discourage them. OBJECTIVES: In order to bring this activity to largeraudiences with a few instructors, we added a technological tool called augmented reality tothe paper puzzle. MATERIALS AND METHODS: The app was developed using Unity, and3D molecules obtained from Protein Data Bank. RESULTS AND DISCUSSION: Using thisapp the students were able to check their achievements as they progress through theactivity. The augmented reality also allowed the addition of more information to the cardslike answers to frequently asked questions and information via flashcards. The virtualflashcards displayed on the tablet screens show information such as the molecular 3Dstructure, and clues for assembling the puzzle. CONCLUSIONS: The above-mentionedtechnological improvement has enabled its use in larger classrooms with fewer instructorssince the students are able to have access to clues and discuss with the peers. Thus, thepaper puzzle is still the way students interact with each other, but the technological supportgives them more autonomy to solve the proposed exercises.

  6. Bringing the Science of JWST to the Public (United States)

    Green, Joel D.; Smith, Denise A.; Lawton, Brandon L.; Meinke, Bonnie K.; Jirdeh, Hussein


    The James Webb Space Telescope is the successor to the Hubble Space Telescope. STScI and the Office of Public Outreach are committed to bringing awareness of the technology, the excitement, and the future science potential of this great observatory to the public and to the scientific community, prior to its 2018 launch. The challenges in ensuring the high profile of JWST (understanding the infrared, the vast distance to the telescope's final position, and the unfamiliar science territory) requires us to lay the proper background, particularly in the area of spectroscopy. We currently engage the full range of the public and scientific communities using a variety of high impact, memorable initiatives, in combination with modern technologies to extend reach, linking the science goals of Webb to the ongoing discoveries being made by Hubble., the public hub for scientific information related to JWST, is now open. We have injected Webb-specific content into ongoing outreach programs: for example, partnering with high impact science communicators such as MinutePhysics to produce timely and concise content; partnering with musicians and artists to link science and art. Augmented reality apps showcase NASA’s telescopes in a format usable by anyone with a smartphone, and visuals from increasingly affordable 3D VR technologies.

  7. Using Multimedia to Bring Science News to the Public (United States)

    O'Riordan, C.; Stein, B.; Lorditch, E. M.


    Creative partnerships between scientists and journalists open new opportunities to bring the excitement of scientific discoveries to wider audiences. Research tells us that the majority of the general public now gets more science and technology news from the Internet than from TV sources (2014 NSF Science and Engineering Indicators). In order to reach these audiences news organizations must embrace multiple forms of multimedia. We will review recent research on how the new multimedia landscape is changing the way that science news is consumed and how news organizations are changing the way they deliver news. News programs like Inside Science, and other examples of new partnerships that deliver research news to journalists, teachers, students, and the general public will be examined. We will describe examples of successful collaborations including an article by a former Newsweek science reporter entitled "My 1975 'Cooling World' Story Doesn't Make Today's Climate Scientists Wrong," which got reprinted in Slate, RealClearScience, and mentioned in and USA Today.

  8. Bringing gender sensitivity into healthcare practice: a systematic review. (United States)

    Celik, Halime; Lagro-Janssen, Toine A L M; Widdershoven, Guy G A M; Abma, Tineke A


    Despite the body of literature on gender dimensions and disparities between the sexes in health, practical improvements will not be realized effectively as long as we lack an overview of the ways how to implement these ideas. This systematic review provides a content analysis of literature on the implementation of gender sensitivity in health care. Literature was identified from CINAHL, PsycINFO, Medline, EBSCO and Cochrane (1998-2008) and the reference lists of relevant articles. The quality and relevance of 752 articles were assessed and finally 11 original studies were included. Our results demonstrate that the implementation of gender sensitivity includes tailoring opportunities and barriers related to the professional, organizational and the policy level. As gender disparities are embedded in healthcare, a multiple track approach to implement gender sensitivity is needed to change gendered healthcare systems. Conventional approaches, taking into account one barrier and/or opportunity, fail to prevent gender inequality in health care. For gender-sensitive health care we need to change systems and structures, but also to enhance understanding, raise awareness and develop skills among health professionals. To bring gender sensitivity into healthcare practice, interventions should address a range of factors. Copyright © 2010. Published by Elsevier Ireland Ltd.

  9. Bringing solar light to the bottom of the pyramid

    Energy Technology Data Exchange (ETDEWEB)

    Graham, S. [SGA Energy Ltd., Ottawa, ON (Canada)


    This presentation described the efforts in bringing solar light to areas of Rwanda, Uganda and the Congo that are currently unserved by electricity. In particular, it highlighted the contributions made by Light Up the World Foundation (LUTW) and the International Gorilla Conservation Programme (IGCP) to improve the quality of life in periphery villages by introducing solar LED lighting in 6 pilot villages. Efficient, long-lasting white LED lamps combined with solar can provide a low cost alternative to the current light source, which is kerosene, diesel and candles. It was noted that the technology exists, but the challenge lies in reaching the market and making a sustainable intervention. The operating parameters of solar panels, LED lamps and batteries were listed with reference to output power, open circuit voltage, maximum power voltage, maximum power current, and capacity. The service life of these devices was also listed along with estimates of their operating costs. The project needs were also identified. It was emphasized that financial support of IGCP and LUTW is needed to support private sector development and market expansion to other areas of Africa. figs.

  10. Bringing Classroom-Based Assessment into the EFL classroom

    Directory of Open Access Journals (Sweden)

    Andrew Finch


    Full Text Available   This paper describes how English as a Foreign Language (EFL teachers can bring reliable, valid, user-friendly assessment into their classrooms, and thus improve the quality of learning that occurs there. Based on the experience of the author as a an EFL teacher and teacher-trainer, it is suggested that the promotion and development of autonomy, intrinsic motivation, and self-esteem that takes place in a Classroom-Based Assessment (CBA environment facilitates an holistic approach to language learning and prepares the students for the high-stakes tests that often determine their motivation for learning English. Rather than relying on the memorization of language code, form, lexis, and prepared answers, students who have learned in a CBA environment are able to self-assess, peer-assess, build portfolios, and edit their own work. Not only does this reduce the assessment burden on the teacher, but it also develops the skills of problem-solving, critical thinking, and summarization in the students, in addition to a heightened awareness of the language-learning process. By learning how to set goals, assess their achievements, and reflect on their future learning needs, students become more efficient language learners. While acknowledging the place of standardized, summative tests in contemporary society, it is suggested that CBA in the EFL classroom can enhance long-term learning and consequently enable and empower students to prepare for their future learning needs.

  11. Dubna - A University Town Exhibition Science Bringing Nations Together

    CERN Multimedia


    1994 marked the opening of the Dubna International University of Nature, Society and Man. It was established on the initiative of the JINR Directorate and supported by the Academy of Natural Sciences of Russia. An integral part of the University is the JINR University Centre which offers educational programmes in high energy physics, nuclear physics, nuclear methods in condensed matter physics, applied physics, and radio-biology.

  12. Future clinical trials in DIPG: bringing epigenetics to the clinic

    Directory of Open Access Journals (Sweden)

    Andres E. Morales La Madrid


    Full Text Available In spite of major recent advances in DIPG molecular characterization, this body of knowledge has not yet translated into better treatments.To date,more than 250 clinical trials evaluating radiotherapy along with conventional cytotoxic chemotherapy as well as newer biologic agents,have failed to improve the dismal outcome when compared to palliative radiation alone.The biology of DIPG remained unknown until recently when the neurosurgical expertise along with the recognition by the scientific and clinical community of the importance of tissue sampling at diagnosis;ideally in the context of a clinical trial and by trained neurosurgical teams to maximize patient safety.These pre-treatment tumor samples,and others coming from tissue obtained post-mortem,have yielded new insights into DIPG molecular biology.We now know that DIPG comprises a heterogeneous disease with variable molecular phenotypes, different from adult high grade glioma,other non-pontine pediatric high grade gliomas and even between pontine gliomas.The discovery of histone H3.3 or H3.1 mutations has been an important step forward in understanding tumor formation,maintenance and progression.Pharmacologic reversal of DIPG histone demethylation therefore offers an important potential intervention strategy for the treatment of DIPG.To date,clinical trials of newly diagnosed or progressive DIPG with epigenetic modifiers have been unsuccessful.Whether this failure represents limited activity of the agents used,their CNS penetration,redundant pathways within the tumor,or the possibility that histone mutations are necessary only to initiate DIPGs but not maintain their growth,suggest that a great deal still needs to be elucidated in both the underlying biology of these pathways,and the drugs designed to target them.In this review, we discuss the role of both epigenetic and genetic mutations within DIPG and the development of treatment strategies directed against the unique abnormalities

  13. The mathematics behind biological invasions

    CERN Document Server

    Lewis, Mark A; Potts, Jonathan R


    This book investigates the mathematical analysis of biological invasions. Unlike purely qualitative treatments of ecology, it draws on mathematical theory and methods, equipping the reader with sharp tools and rigorous methodology. Subjects include invasion dynamics, species interactions, population spread, long-distance dispersal, stochastic effects, risk analysis, and optimal responses to invaders. While based on the theory of dynamical systems, including partial differential equations and integrodifference equations, the book also draws on information theory, machine learning, Monte Carlo methods, optimal control, statistics, and stochastic processes. Applications to real biological invasions are included throughout. Ultimately, the book imparts a powerful principle: that by bringing ecology and mathematics together, researchers can uncover new understanding of, and effective response strategies to, biological invasions. It is suitable for graduate students and established researchers in mathematical ecolo...

  14. Biological post


    Kumar, B. Suresh; Kumar, Senthil; N S Mohan Kumar; Karunakaran, J. V.


    Anterior tooth fracture as a result of traumatic injuries, is frequently encountered in endodontic practice. Proper reconstruction of extensively damaged teeth can be achieved through the fragment reattachment procedure known as ?biological restoration.? This case report refers to the esthetics and functional recovery of extensively damaged maxillary central incisor through the preparation and adhesive cementation of ?biological post? in a young patient. Biological post obtained through extra...

  15. Biological therapeutics

    National Research Council Canada - National Science Library

    Greenstein, Ben; Brook, Daniel A


    This introductory textbook covers all the main categories of biological medicines, including vaccines, hormonal preparations, drugs for rheumatoid arthritis and other connective tissue diseases, drugs...

  16. CERN@school: bringing CERN into the classroom (United States)

    Whyntie, T.; Cook, J.; Coupe, A.; Fickling, R. L.; Parker, B.; Shearer, N.


    CERN@school brings technology from CERN into the classroom to aid with the teaching of particle physics. It also aims to inspire the next generation of physicists and engineers by giving participants the opportunity to be part of a national collaboration of students, teachers and academics, analysing data obtained from detectors based on the ground and in space to make new, curiosity-driven discoveries at school. CERN@school is based around the Timepix hybrid silicon pixel detector developed by the Medipix 2 Collaboration, which features a 300 μm thick silicon sensor bump-bonded to a Timepix readout ASIC. This defines a 256-by-256 grid of pixels with a pitch of 55 μm, the data from which can be used to visualise ionising radiation in a very accessible way. Broadly speaking, CERN@school consists of a web portal that allows access to data collected by the Langton Ultimate Cosmic ray Intensity Detector (LUCID) experiment in space and the student-operated Timepix detectors on the ground; a number of Timepix detector kits for ground-based experiments, to be made available to schools for both teaching and research purposes; and educational resources for teachers to use with LUCID data and detector kits in the classroom. By providing access to cutting-edge research equipment, raw data from ground and space-based experiments, CERN@school hopes to provide the foundation for a programme that meets the many of the aims and objectives of CERN and the project's supporting academic and industrial partners. The work presented here provides an update on the status of the programme as supported by the UK Science and Technology Facilities Council (STFC) and the Royal Commission for the Exhibition of 1851. This includes recent results from work with the GridPP Collaboration on using grid resources with schools to run GEANT4 simulations of CERN@school experiments.

  17. Imaginative ethics--bringing ethical praxis into sharper relief. (United States)

    Hansson, Mats G


    The empirical basis for this article is three years of experience with ethical rounds at Uppsala University Hospital. Three standard approaches of ethical reasoning are examined as potential explanations of what actually occurs during the ethical rounds. For reasons given, these are not found to be satisfying explanations. An approach called "imaginative ethics", is suggested as a more satisfactory account of this kind of ethical reasoning. The participants in the ethical rounds seem to draw on a kind of moral competence based on personal life experience and professional competence and experience. By listening to other perspectives and other experiences related to one particular patient story, the participants imagine alternative horizons of moral experience and explore a multitude of values related to clinical practice that might be at stake. In his systematic treatment of aesthetics in the Critique of Judgement, Kant made use of an operation of thought that, if applied to ethics, will enable us to be more sensitive to the particulars of each moral situation. Based on this reading of Kant, an account of imaginative ethics is developed in order to bring the ethical praxis of doctors and nurses into sharper relief. The Hebraic and the Hellenic traditions of imagination are used in order to illuminate some of the experiences of ethical rounds. In conclusion, it is argued that imaginative ethics and principle-based ethics should be seen as complementary in order to endow a moral discourse with ethical authority. Kantian ethics will do the job if it is remembered that Kant suggested only a modest, negative role of principle-based deliberation.

  18. Equity and what secondary science teachers bring to the classroom (United States)

    Austin, Barbara Anne

    The demographics of people working in science-based careers do not match the demographics of the larger society. In particular, people who self-identify as Hispanic are underrepresented among working scientists. One reason may be the influence of formal schooling and more specifically, the behaviors of teachers in secondary science classrooms. This study looks at the practices of eight secondary science teachers at two schools at which 62% of the enrolled students declare their ethnicity as Hispanic. All of the teachers have at least three years of experience. Through interviews with the teachers, classroom observation, and interviews with other faculty, this research elucidates typical behaviors and attitudes surrounding teaching science in these settings. In spite of having a deficit view of their students, they all express interest in and concern about the students they teach. Their characterizations of teaching practices and classroom behaviors do not incorporate strategies designed to promote content learning through culturally relevant curriculum. Instead, they use mainstream-situated approaches that develop science content knowledge, vocabulary, procedures, and skills targeted toward high achievement on state and district standardized tests leading toward graduation or success in college. These approaches are consistent with a view of equity that increases the participation of underrepresented groups in science based careers in that it gives students the skills and knowledge they will need in order to successfully pursue these careers. Additionally, they behave in ways that are consistent with equitable strategies such as using inquiry based teaching, serving as role models, and providing a structured learning environment. This research informs the literature base for instructional systems designers by identifying what that teachers situated in culturally diverse classrooms bring to professional development programs targeted toward making secondary science

  19. Gender equity and tobacco control: bringing masculinity into focus. (United States)

    Morrow, Martha; Barraclough, Simon


    Gender is a key but often overlooked--determinant of tobacco use, especially in Asia, where sex-linked differences in prevalence rates are very large. In this article we draw upon existing data to consider the implications of these patterns for gender equity and propose approaches to redress inequity through gender-sensitive tobacco control activities. International evidence demonstrates that, in many societies, risk behaviours (including tobacco use) are practised substantially more by men and boys, and are also viewed as expressions of masculine identity. While gender equity focuses almost exclusively on the relative disadvantage of girls and women that exists in most societies, disproportionate male use of tobacco has profound negative consequences for men (as users) and for women (nonusers). Surprisingly, health promotion and tobacco control literature rarely focus on the role of gender in health risks among boys and men. However, tobacco industry marketing has masterfully incorporated gender norms, and also other important cultural values, to ensure its symbols are context-specific. By addressing gender-specific risks within the local cultural context--as countries are enjoined to do within the Framework Convention's Guiding Principles--it may be possible to accelerate the impact of mechanisms such as tobacco pricing, restrictions on marketing, smoking bans and provision of accurate information. It is essential that we construct a new research-to-policy framework for gender-sensitive tobacco control. Successful control of tobacco can only be strengthened by bringing males, and the concept of gender as social construction, back into our research and discussion on health and gender equity.

  20. Environmental Biology

    Indian Academy of Sciences (India)

    BOOK I REVIEW. Environmental Biology. Man and his Environment. M D Subhash Chandran ... logy and Field Biology (Harper Collins, 1990):. "The fragmentation of ecology into specialised subdisciplines with their ... momentous events of the decade like the Earth. Summit of 1992! Despite the need to revise and update.

  1. Mesoscopic biology

    Indian Academy of Sciences (India)

    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological ...

  2. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue


    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  3. Mesoscopic biology

    Indian Academy of Sciences (India)

    National Center for Biological Sciences, Tata Institute of Fundamental Research,. UAS-GKVK Campus ... In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the ... study of some of the design principles of these machines; in particular at the level of an individual molecule.

  4. tRNA's modifications bring order to gene expression. (United States)

    Gustilo, Estella M; Vendeix, Franck Ap; Agris, Paul F


    The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticodon domain control gene expression. Modifications at the anticodon's wobble position are required for recognition of rarely used codons and restrict or expand codon recognition depending on their chemistries. A shift of the translational reading frame occurs in the absence of modifications at either wobble position-34 or the conserved purine-37, 3'-adjacent to the anticodon, causing expression of alternate protein sequences. These modifications have in common their contribution of order to tRNA's anticodon.

  5. ISSLIVE! Bringing the Space Station to Every Generation (United States)

    Harris, Philip D.; Price, Jennifer B.; Severance, Mark; Blue, Regina; Khan, Ahmed; Healy, Matthew D.; Ehlinger, Jesse B.


    traditional education system, ISSLive! provides a single, interactive, and engaging experience to learn about the ISS and its role in space exploration, international collaboration, and science. While traditional students are using ISSLive! in the classroom, their parents, grandparents, and friends are using it at home. ISSLive! truly brings the daily operations of the ISS into the daily lives of the public from every generation.

  6. Kaiserschnitten Wien - Let's bring the forest in the city

    Directory of Open Access Journals (Sweden)

    Ajda Primožič


    Full Text Available The location is part of the Vienna River Valley, known as "Wiental", one of the most dissonant, incongruous, and contested areas of Vienna. Depending on one’s perspective, the Vienna River Valley can be viewed as a transit corridor, an unresolved urban area, an urban interface, an inter- zone, an infrastructure bundle, an ugly wound in the urban landscape, a socially charged boundary, etc. We started the project with urban pattern analyses on different scales: the scale of the city, the scale of Wiental (from Schönbrunn to Hofburg and on a minor scale, i.e. the scale of the project.The analysis showed that Wiental constitutes the main connection between the city centre and suburbia and the countryside in the background of the city. With its clear morphological importance, it could become a green axis of the city, a pleasant place for people, rather than having only an infrastructural role. Our concept is to bring new character to Wiental by making it a pedestrian- and cyclist-friendly green axis. Our initial goal was to reduce car traffic. We proposed introducing a park-and-ride system, which would become a point of transfer where car traffic is replaced by public transport and cycle traffic. Through the afforestation of Wiental, the area could become a park or recreational route, and the quality of life in the area would improve.An important aspect of the project was dealing with the Danube. We proposed to manage the flood peaks by introducing a dam, and after the point of regulation, we arranged the River into two levels: an ambient upper flow and infrastructural lower flow in the existing channel. Also, by rearranging "Naschmarkt" with the Danube uncovered, we predicted an extension of tourism from the city centre to Schönbrunn by bicycle or on foot, which could be followed by an expansion of the public programme. We wanted to show that the Danube, with an appropriate environment, could become a significant element of the city structure.

  7. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi


    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  8. tRNA’s Modifications Bring Order to Gene Expression (United States)

    Gustilo, Estella M.; Vendeix, Franck A.P.; Agris, Paul F.


    Summary The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA’s anticodon domain control gene expression. Modifications at the anticodon’s wobble position are required for recognition of rarely used codons, and restrict or expand codon recognition depending on their chemistries. A shift of the translational reading frame occurs in the absence of modifications at either wobble position-34 or the conserved purine-37, 3’-adjacent to the anticodon, causing expression of alternate protein sequences. These modifications have in common their contribution of order to tRNA’s anticodon. PMID:18378185

  9. Photo Animation Brings Scientists Back to Life in the Classroom

    Directory of Open Access Journals (Sweden)

    Lara K. Goudsouzian


    Full Text Available In biology textbooks and in lecture slides, it is customary to describe the significance of a historical scientific experiment alongside a still photograph of the scientist who performed the work.  This method communicates information about the scientists' works, but can be a dry method to describe an exciting and dynamic historical individual.  I have developed a method to animate still photographs and engravings of historical scientists and narrate them in the first person.  This method is rapid, inexpensive, and does not require more than average technical ability.  The animated historical scientists directly address the students to educate them about their own personal lives, struggles, and achievements.

  10. Biological Technicians (United States)

    ... the direction of biologists or other scientists. Work Schedules Most biological technicians work full time and keep ... more efficient ways than are currently used. New applications of biotechnology may be the subject of research ...

  11. From the Moon: Bringing Space Science to Diverse Audiences (United States)

    Runyon, C. J.; Hall, C.; Joyner, E.; Meyer, H. M.; M3 Science; E/PO Team


    NASA's Apollo missions held a place in the mindset of many Americans - we dared to go someplace where humans had never set foot, a place unknown and beyond our imaginations. These early NASA missions and discoveries resulted in an enhanced public understanding of the Moon. Now, with the human element so far removed from space exploration, students must rely on textbooks, TV's, and computers to build their understanding of our Moon. However, NASA educational materials about the Moon are stale and out-of-date. In addition, they do not effectively address 21st Century Skills, an essential for today's classrooms. Here, we present a three-part model for developing opportunities in lunar science education professional development that is replicable and sustainable and integrates NASA mission-derived data (e.g., Moon Mineralogy Mapper (M3)/Chandrayaan-1). I) With the return of high resolution/high spatial data from M3/Chandrayaan-1, we can now better explore and understand the compositional variations on the lunar surface. Data and analysis techniques from the imaging spectrometer are incorporated into the M3 Educator's Guide: Seeing the Moon in a New Light. The guide includes an array of activities and lessons to help educators and students understand how NASA is currently exploring the Moon. The guide integrates NASA maps and data into the interactive lessons, bringing the excitement of scientific exploration and discovery into the classroom. II) Utilizing the M3 Educator's Guide as well as educational activities from more current NASA lunar missions, we offer two sustained professional development opportunities for educators to explore the Moon through interactive and creative strategies. 1) Geology of the Moon, an online course offered through Montana State University's National Teacher Enhancement Network, is a 3-credit graduate course. 2) Fly Me to the Moon, offered through the College of Charleston's Office of Professional Development in Education, is a two

  12. Biological indicators and biological indication

    Energy Technology Data Exchange (ETDEWEB)

    Haseloff, H.P.


    Pollutants in the environment cause more and more situations of burden for living beings. In certain organisms, i.e. in biological indicators, there is a correlation between the extent of the damage and the degree of the burden. That is why environmental burdens can be recognized and, in part, be quantitatively recorded. Depending of the choice of materials and the damage parameters the respective differentiated statements can be made. Compared to technical measuring stations biological indicators facilitate the assessment of situations of burden with the help of biological-ecological parameters.

  13. Bringing New Families to the Museum One Baby at a Time (United States)

    Herman, Alicia


    "Bring Your Baby to the Danforth Museum of Art" is a program for mothers. Unlike other museum programs that focus on the needs of children, Bring Your Baby caters to the intellectual interests of the adult parent. Parents learn about artworks, play with babies in a beautiful environment, and socialize with other families. The program is…

  14. 36 CFR 1280.18 - May I bring guns or other weapons onto NARA property? (United States)


    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false May I bring guns or other weapons onto NARA property? 1280.18 Section 1280.18 Parks, Forests, and Public Property NATIONAL ARCHIVES... Conduct on NARA Property? Prohibited Activities § 1280.18 May I bring guns or other weapons onto NARA...

  15. System biology of gene regulation. (United States)

    Baitaluk, Michael


    A famous joke story that exhibits the traditionally awkward alliance between theory and experiment and showing the differences between experimental biologists and theoretical modelers is when a University sends a biologist, a mathematician, a physicist, and a computer scientist to a walking trip in an attempt to stimulate interdisciplinary research. During a break, they watch a cow in a field nearby and the leader of the group asks, "I wonder how one could decide on the size of a cow?" Since a cow is a biological object, the biologist responded first: "I have seen many cows in this area and know it is a big cow." The mathematician argued, "The true volume is determined by integrating the mathematical function that describes the outer surface of the cow's body." The physicist suggested: "Let's assume the cow is a sphere...." Finally the computer scientist became nervous and said that he didn't bring his computer because there is no Internet connection up there on the hill. In this humorous but explanatory story suggestions proposed by theorists can be taken to reflect the view of many experimental biologists that computer scientists and theorists are too far removed from biological reality and therefore their theories and approaches are not of much immediate usefulness. Conversely, the statement of the biologist mirrors the view of many traditional theoretical and computational scientists that biological experiments are for the most part simply descriptive, lack rigor, and that much of the resulting biological data are of questionable functional relevance. One of the goals of current biology as a multidisciplinary science is to bring people from different scientific areas together on the same "hill" and teach them to speak the same "language." In fact, of course, when presenting their data, most experimentalist biologists do provide an interpretation and explanation for the results, and many theorists/computer scientists aim to answer (or at least to fully describe

  16. The Concept of Biological/Ecological interaction: contributions to studies in Epistemology of Biology and Biology Education

    Directory of Open Access Journals (Sweden)

    Fúlvia Eloá Maricato


    Full Text Available Epistemology of biology has been the subject of many discussions in the field of Science and Biology education. This study aimed to bring new elaborations to enrich these discussions, highlighting its importance and how this epistemology canbe inserted in Science and Biology education. The presented investigation is anchored on three main pillars:(i some reflections on epistemologyof biology; (iithe importance and vagueness of the concept of biological/ecological interaction in literature; (iii the empirical investigation on epistemologyof biology by this research group. The semiotic analysis allowed us to infer that the research subjects: expressed to understand the importance, amplitude and centrality of this concept to the Biology Knowledge; evolved from a starting vision in which it was only understood the biological interactions with the external environment to one in which we start to understand the biological interactions in several levels of organization thus, advancing from a syncretic/abductive thinking to a deductive reasoning, going through the inductive one; and are concerned on how to teach the studied concept to their future students. This analysisallowed some reflections that can contribute to a creation of a solid epistemology of biology in its many contexts, with the main focus on initial teacher training.

  17. SeaView: bringing EarthCube to the Oceanographer (United States)

    Stocks, K. I.; Diggs, S. C.; Arko, R. A.; Kinkade, D.; Shepherd, A.


    As new instrument types are developed, and new observational programs start, that support a growing community of "dry" oceanographers, the ability to find, access, and visualize existing data of interest becomes increasingly critical. Yet ocean data, when available, is are held in multiple data facilities, in different formats, and accessible through different pathways. This creates practical problems with integrating and working across different data sets. The SeaView project is building connections between the rich data resources in five major oceanographic data facilities - BCO-DMO, CCHDO, OBIS, OOI, and R2R* - creating a federated set of thematic data collections that are organized around common characteristics (geographic location, time, expedition, program, data type, etc.) and published online in Web Accessible Folders using standard file formats such as ODV and NetCDF. The work includes not simply reformatting data, but identifying and, where possible, addressing interoperability challenges: which common identifiers for core concepts can connect data across repositories, which terms a scientist may want to search that, if added to the data repositories, will increase discoverability; the presence of duplicate data across repositories, etc. We will present the data collections available to date, including data from the OOI Pioneer Array region, and seek scientists' input on the data types and formats they prefer, the tools they use to analyze and visualize data, and their specific recommendations for future data collections to support oceanographic science. * Biological and Chemical Oceanography Data Management Office (BCO-DMO), CLIVAR and Carbon Hydrographic Data Office (CCHDO), International Ocean Biogeographic Information System (iOBIS), Ocean Observatories Initiative (OOI), and Rolling Deck to Repository (R2R) Program.

  18. Euarchontan Opsin Variation Brings New Focus to Primate Origins. (United States)

    Melin, Amanda D; Wells, Konstans; Moritz, Gillian L; Kistler, Logan; Orkin, Joseph D; Timm, Robert M; Bernard, Henry; Lakim, Maklarin B; Perry, George H; Kawamura, Shoji; Dominy, Nathaniel J


    Debate on the adaptive origins of primates has long focused on the functional ecology of the primate visual system. For example, it is hypothesized that variable expression of short- (SWS1) and middle-to-long-wavelength sensitive (M/LWS) opsins, which confer color vision, can be used to infer ancestral activity patterns and therefore selective ecological pressures. A problem with this approach is that opsin gene variation is incompletely known in the grandorder Euarchonta, that is, the orders Scandentia (treeshrews), Dermoptera (colugos), and Primates. The ancestral state of primate color vision is therefore uncertain. Here, we report on the genes (OPN1SW and OPN1LW) that encode SWS1 and M/LWS opsins in seven species of treeshrew, including the sole nocturnal scandentian Ptilocercus lowii. In addition, we examined the opsin genes of the Central American woolly opossum (Caluromys derbianus), an enduring ecological analogue in the debate on primate origins. Our results indicate: 1) retention of ultraviolet (UV) visual sensitivity in C. derbianus and a shift from UV to blue spectral sensitivities at the base of Euarchonta; 2) ancient pseudogenization of OPN1SW in the ancestors of P. lowii, but a signature of purifying selection in those of C. derbianus; and, 3) the absence of OPN1LW polymorphism among diurnal treeshrews. These findings suggest functional variation in the color vision of nocturnal mammals and a distinctive visual ecology of early primates, perhaps one that demanded greater spatial resolution under light levels that could support cone-mediated color discrimination. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  19. Biological terrorism. (United States)

    Moran, Gregory J; Talan, David A; Abrahamian, Fredrick M


    A biological terrorism event could have a large impact on the general population and health care system. The impact of an infectious disaster will most likely be great to emergency departments, and the collaboration between emergency and infectious disease specialists will be critical in developing an effective response. A bioterrorism event is a disaster that requires specific preparations beyond the usual medical disaster planning. An effective response would include attention to infection control issues and plans for large-scale vaccination or antimicrobial prophylaxis. This article addresses some general issues related to preparing an effective response to a biological terrorism event. It will also review organisms and toxins that could be used in biological terrorism, including clinical features, management, diagnostic testing, and infection control.

  20. Biological preconcentrator (United States)

    Manginell, Ronald P [Albuquerque, NM; Bunker, Bruce C [Albuquerque, NM; Huber, Dale L [Albuquerque, NM


    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  1. Biological Oceanography (United States)

    Abbott, M. R.


    Within the framework of global biogeochemical cycles and ocean productivity, there are two areas that will be of particular interest to biological oceanography in the 1990s. The first is the mapping in space time of the biomass and productivity of phytoplankton in the world ocean. The second area is the coupling of biological and physical processes as it affects the distribution and growth rate of phytoplankton biomass. Certainly other areas will be of interest to biological oceanographers, but these two areas are amenable to observations from satellites. Temporal and spatial variability is a regular feature of marine ecosystems. The temporal and spatial variability of phytoplankton biomass and productivity which is ubiquitous at all time and space scales in the ocean must be characterized. Remote sensing from satellites addresses these problems with global observations of mesocale (2 to 20 days, 10 to 200 km) features over a long period of time.

  2. Biological rhythms (United States)

    Halberg, F.


    An overview is given of basic features of biological rhythms. The classification of periodic behavior of physical and psychological characteristics as circadian, circannual, diurnal, and ultradian is discussed, and the notion of relativistic time as it applies in biology is examined. Special attention is given to circadian rhythms which are dependent on the adrenocortical cycle. The need for adequate understanding of circadian variations in the basic physiological indicators of an individual (heart rate, body temperature, systolic and diastolic blood pressure, etc.) to ensure the effectiveness of prophylactic and therapeutic measures is stressed.

  3. Neuroblastoma: Developmental Biology, Cancer Genomics, and Immunotherapy (United States)

    Cheung, Nai-Kong V.; Dyer, Michael A.


    Neuroblastoma is a solid tumor that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained toward developing risk-based therapies and ultimately improving outcome. Here we review the key discoveries in the developmental biology, molecular genetics, and immunology of neuroblastoma, as well as new translational tools to bring these promising scientific advances into the clinic. PMID:23702928

  4. Biology Notes. (United States)

    School Science Review, 1983


    Describes laboratory procedures, demonstrations, and classroom activities/materials, including water relation exercise on auxin-treated artichoke tuber tissue; aerobic respiration in yeast; an improved potometer; use of mobiles in biological classification, and experiments on powdery mildews and banana polyphenol oxidase. Includes reading lists…

  5. Scaffolded biology. (United States)

    Minelli, Alessandro


    Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as Dawkins' extended phenotype, Turner's extended organism, Oyama's Developmental Systems Theory and Odling-Smee's niche construction theory. Last in time is the description of biological phenomena in terms of hybrids between an organism (scaffolded system) and a living or non-living scaffold, forming unit systems to study processes such as reproduction and development. As scaffold, eventually, we can define any resource used by the biological system, especially in development and reproduction, without incorporating it as happens in the case of resources fueling metabolism. Addressing biological systems as functionally scaffolded systems may help pointing to functional relationships that can impart temporal marking to the developmental process and thus explain its irreversibility; revisiting the boundary between development and metabolism and also regeneration phenomena, by suggesting a conceptual framework within which to investigate phenomena of regular hypermorphic regeneration such as characteristic of deer antlers; fixing a periodization of development in terms of the times at which a scaffolding relationship begins or is terminated; and promoting plant galls to legitimate study objects of developmental biology.

  6. Marine Biology (United States)

    Dewees, Christopher M.; Hooper, Jon K.


    A variety of informational material for a course in marine biology or oceanology at the secondary level is presented. Among the topics discussed are: food webs and pyramids, planktonic blooms, marine life, plankton nets, food chains, phytoplankton, zooplankton, larval plankton and filter feeders. (BT)

  7. Environmental Biology

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 5. Environmental Biology - Man and his Environment. M D Subhash Chandran. Book Review Volume ... Author Affiliations. M D Subhash Chandran1. Department of Botany, Dr Baliga College of Arts and Science, Kumta 581343, Karnataka, India.

  8. Biological timekeeping

    DEFF Research Database (Denmark)

    Lloyd, David


    , the networks that connect differenttime domains and the oscillations, rhythms and biological clocks that coordinate andsynchronise the complexity of the living state.“It is the pattern maintained by this homeostasis, which is the touchstone ofour personal identity. Our tissues change as we live: the food we...

  9. (Biological dosimetry)

    Energy Technology Data Exchange (ETDEWEB)

    Preston, R.J.


    The traveler attended the 1st International Conference on Biological Dosimetry in Madrid, Spain. This conference was organized to provide information to a general audience of biologists, physicists, radiotherapists, industrial hygiene personnel and individuals from related fields on the current ability of cytogenetic analysis to provide estimates of radiation dose in cases of occupational or environmental exposure. There is a growing interest in Spain in biological dosimetry because of the increased use of radiation sources for medical and occupational uses, and with this the anticipated and actual increase in numbers of overexposure. The traveler delivered the introductory lecture on Biological Dosimetry: Mechanistic Concepts'' that was intended to provide a framework by which the more applied lectures could be interpreted in a mechanistic way. A second component of the trip was to provide advice with regard to several recent cases of overexposure that had been or were being assessed by the Radiopathology and Radiotherapy Department of the Hospital General Gregorio Maranon'' in Madrid. The traveler had provided information on several of these, and had analyzed cells from some exposed or purportedly exposed individuals. The members of the biological dosimetry group were referred to individuals at REACTS at Oak Ridge Associated Universities for advice on follow-up treatment.

  10. Synthetic biology: applications come of age. (United States)

    Khalil, Ahmad S; Collins, James J


    Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will change our lives over the coming years, leading to cheaper drugs, 'green' means to fuel our cars and targeted therapies for attacking 'superbugs' and diseases, such as cancer. The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.

  11. Morphogenesis and pattern formation in biological systems experiments and models

    CERN Document Server

    Noji, Sumihare; Ueno, Naoto; Maini, Philip


    A central goal of current biology is to decode the mechanisms that underlie the processes of morphogenesis and pattern formation. Concerned with the analysis of those phenomena, this book covers a broad range of research fields, including developmental biology, molecular biology, plant morphogenesis, ecology, epidemiology, medicine, paleontology, evolutionary biology, mathematical biology, and computational biology. In Morphogenesis and Pattern Formation in Biological Systems: Experiments and Models, experimental and theoretical aspects of biology are integrated for the construction and investigation of models of complex processes. This collection of articles on the latest advances by leading researchers not only brings together work from a wide spectrum of disciplines, but also provides a stepping-stone to the creation of new areas of discovery.

  12. Foldit Biology (United States)


    the goal of revolutionizing the way biology curriculum is presented for K12 student worldwide. APPROACH To achieve this objective, we...will inform the iterative design of Foldit, and other educational games and activities, so that they provide students/players with optimal learning...Foldit’s use in education and for education research at the Center for Game Science generally. Another exciting development for the future is the

  13. Biological cages


    Janssen, M. E.; NGUYEN, C; Beckham, R.; Larson, A.


    Restoring a stable anterior column is essential to achieve normal spinal biomechanics. A variety of mechanical spacers have been developed and advocated for both anterior and posterior approaches. The ability to radiographically assess the “biology” of bone incorporation in these mechanical (metal) spacers is an inherent limitation. The femoral ring allograft (FRA) and posterior lumbar interbody fusion (PLIF) spacers have been developed as biological cages that permit restoration of the anter...

  14. Crusts: biological (United States)

    Belnap, Jayne; Elias, Scott A.


    Biological soil crusts, a community of cyanobacteria, lichens, mosses, and fungi, are an essential part of dryland ecosystems. They are critical in the stabilization of soils, protecting them from wind and water erosion. Similarly, these soil surface communities also stabilized soils on early Earth, allowing vascular plants to establish. They contribute nitrogen and carbon to otherwise relatively infertile dryland soils, and have a strong influence on hydrologic cycles. Their presence can also influence vascular plant establishment and nutrition.

  15. Pressure profiles of the BRing based on the simulation used in the CSRm

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J.C., E-mail: [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Li, P., E-mail: [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Yang, J.C.; Yuan, Y.J. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Wu, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chai, Z.; Luo, C. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Dong, Z.Q. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Zheng, W.H. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhao, H.; Ruan, S.; Wang, G.; Liu, J.; Chen, X.; Wang, K.D.; Qin, Z.M. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yin, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)


    HIAF-BRing, a new multipurpose accelerator facility of the High Intensity heavy-ion Accelerator Facility project, requires an extremely high vacuum lower than 10{sup −11} mbar to fulfill the requirements of radioactive beam physics and high energy density physics. To achieve the required process pressure, the bench-marked codes of VAKTRAK and Molflow+ are used to simulate the pressure profiles of the BRing system. In order to ensure the accuracy of the implementation of VAKTRAK, the computational results are verified by measured pressure data and compared with a new simulation code BOLIDE on the current synchrotron CSRm. Since the verification of VAKTRAK has been done, the pressure profiles of the BRing are calculated with different parameters such as conductance, out-gassing rates and pumping speeds. According to the computational results, the optimal parameters are selected to achieve the required pressure for the BRing.

  16. The Eighth Central European Conference ?Chemistry towards Biology?: Snapshot?


    Perczel, Andr?s; Atanasov, Atanas G.; Sklen??, Vladim?r; Nov??ek, Ji??; Papou?kov?, Veronika; Kade??vek, Pavel; ??dek, Luk??; Koz?owski, Henryk; Wat?y, Joanna; Hecel, Aleksandra; Ko?kowska, Paulina; Ko?a, Jaroslav; Svobodov?-Va?ekov?, Radka; Pravda, Luk??; Sehnal, David


    The Eighth Central European Conference “Chemistry towards Biology” was held in Brno, Czech Republic, on August 28–September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered “Chemistry towards Biology”, meaning that the event welcomed chemists working on biology-related problems, biol...

  17. The Current Status of the Philosophy of Biology (United States)

    Takacs, Peter; Ruse, Michael


    The philosophy of biology today is one of the most exciting areas of philosophy. It looks critically across the life sciences, teasing out conceptual issues and difficulties bringing to bear the tools of philosophical analysis to achieve clarification and understanding. This essay surveys work in all of the major directions of research: evolutionary theory and the units/levels of selection; evolutionary developmental biology; reductionism; ecology; the species problem; teleology; evolutionary epistemology; evolutionary ethics; and progress. There is a comprehensive bibliography.

  18. The Current Status of the Philosophy of Biology (United States)

    Takacs, Peter; Ruse, Michael


    The philosophy of biology today is one of the most exciting areas of philosophy. It looks critically across the life sciences, teasing out conceptual issues and difficulties bringing to bear the tools of philosophical analysis to achieve clarification and understanding. This essay surveys work in all of the major directions of research:…

  19. NATO Advanced Research Workshop, 19-22 May 1997: Rapid Method for Monitoring the Environment for Biological Hazards. (United States)


    The NATO Advanced Research Workshop met for the purpose of bringing to light rapid methods for monitoring the environment for biological hazards such as biological warfare agents, naturally occurring diseases, detection and identification of different biological threats in the environment , dormancy in non-sporulating bacteria and bioluminescence techniques with respect to the rapid detection of microbes in air, water and food.

  20. Biological biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Jorge-Herrero, E. [Servicio de Cirugia Experimental. Clinica Puerta de Hierro, Madrid (Spain)


    There are a number of situations in which substances of biological origin are employed as biomaterials. Most of them are macromolecules derived from isolated connective tissue or the connective tissue itself in membrane form, in both cases, the tissue can be used in its natural form or be chemically treated. In other cases, certain blood vessels can be chemically pretreated and used as vascular prostheses. Proteins such as albumin, collagen and fibrinogen are employed to coat vascular prostheses. Certain polysaccharides have also been tested for use in controlled drug release systems. Likewise, a number of tissues, such as dura mater, bovine pericardium, procine valves and human valves, are used in the preparation of cardiac prostheses. We also use veins from animals or humans in arterial replacement. In none of these cases are the tissues employed dissimilar to the native tissues as they have been chemically modified, becoming a new bio material with different physical and biochemical properties. In short, we find that natural products are being utilized as biomaterials and must be considered as such; thus, it is necessary to study both their chemicobiological and physicomechanical properties. In the present report, we review the current applications, problems and future prospects of some of these biological biomaterials. (Author) 84 refs.

  1. «Amigos con derecho a roce»: una oportunidad para contraer la infección por el virus de la inmunodeficiencia humana en hombres homo/bixesuales con prácticas sexuales de alto riesgo «Fuck buddies»: a high risk behavior for contracting HIV among homo/bisexual men

    Directory of Open Access Journals (Sweden)

    Percy Fernández-Dávila


    involved in UAI when they established relationships with «fuck buddies» as a way to balance their need for sexual expression with their need for sexual security. In these relationships, the partner's serostatus was assessed on the basis of trust and the assumption of sharing the same serologic status. Conclusions: Subjective evaluations (e.g. trust, intuition played a key role in the decision to engage in UAI with «fuck buddies» without precise knowledge of their HIV serostatus. Future approaches need to include the role of subjectivity in making decisions related to risk management and the specific contexts (e.g. type of sexual partner in which UAI takes place.

  2. The Native Mind: Biological Categorization and Reasoning in Development and Across Cultures (United States)

    Medin, Douglas L.; Atran, Scott


    This article describes cross-cultural and developmental research on folk biology: that is, the study of how people conceptualize living kinds. The combination of a conceptual module for biology and cross-cultural comparison brings a new perspective to theories of categorization and reasoning. From the standpoint of cognitive psychology, the…

  3. Creating biological nanomaterials using synthetic biology. (United States)

    Rice, MaryJoe K; Ruder, Warren C


    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems.

  4. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K–12 Community

    Directory of Open Access Journals (Sweden)

    David J. Westenberg


    Full Text Available Exposing K–12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS, “engaging in practices that scientists and engineers actually use.” This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM can play a critical role. ASM encourages its members to engage with the K–12 community by providing networking opportunities and resources for ASM members and K–12 teachers to work together to bring microbiology into the classroom.

  5. Shaping Biological Knowledge: Applications in Proteomics

    Directory of Open Access Journals (Sweden)

    R. Appel


    Full Text Available The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa and a hypothesis-driven (focus on whole bacterial proteomes approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  6. [Applications of synthetic biology in materials science]. (United States)

    Zhao, Tianxin; Zhong, Chao


    Materials are the basis for human being survival and social development. To keep abreast with the increasing needs from all aspects of human society, there are huge needs in the development of advanced materials as well as high-efficiency but low-cost manufacturing strategies that are both sustainable and tunable. Synthetic biology, a new engineering principle taking gene regulation and engineering design as the core, greatly promotes the development of life sciences. This discipline has also contributed to the development of material sciences and will continuously bring new ideas to future new material design. In this paper, we review recent advances in applications of synthetic biology in material sciences, with the focus on how synthetic biology could enable synthesis of new polymeric biomaterials and inorganic materials, phage display and directed evolution of proteins relevant to materials development, living functional materials, engineered bacteria-regulated artificial photosynthesis system as well as applications of gene circuits for material sciences.

  7. CSBB: synthetic biology research at Newcastle University. (United States)

    Goñi-Moreno, Angel; Wipat, Anil; Krasnogor, Natalio


    The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties - Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts and Social Sciences. The CSBB focuses on many different areas of Synthetic Biology, including bioprocessing, computational design and in vivo computation, as well as improving understanding of basic molecular machinery. Such breadth is supported by major national and international research funding, a range of industrial partners in the North East of England and beyond, as well as a large number of doctoral and post-doctoral researchers. The CSBB trains the next generation of scientists through a 1-year MSc in Synthetic Biology. © 2017 The Author(s).

  8. Bottom-up synthetic biology: engineering in a tinkerer's world. (United States)

    Schwille, Petra


    How synthetic can "synthetic biology" be? A literal interpretation of the name of this new life science discipline invokes expectations of the systematic construction of biological systems with cells being built module by module--from the bottom up. But can this possibly be achieved, taking into account the enormous complexity and redundancy of living systems, which distinguish them quite remarkably from design features that characterize human inventions? There are several recent developments in biology, in tight conjunction with quantitative disciplines, that may bring this literal perspective into the realm of the possible. However, such bottom-up engineering requires tools that were originally designed by nature's greatest tinkerer: evolution.

  9. The Bring Your Own Technology Initiative: An Examination of Teachers' Adoption (United States)

    Cardoza, Yanet; Tunks, Jeanne


    This case study explored teachers' concerns, use, and actual practices in their adoption of the Bring Your Own Technology (BYOT) initiative. Participants were 12 secondary teachers in a private school setting. The Concerns-Based Adoption Model tools provided data: Stages of Concern Questionnaire (SoCQ), Levels of Use interview, and the Innovation…

  10. Bring Your Own Device to Secondary School: The Perceptions of Teachers, Students and Parents (United States)

    Parsons, David; Adhikar, Janak


    This paper reports on the first two years of a Bring Your Own Device (BYOD) initiative in a New Zealand secondary school, using data derived from a series of surveys of teachers, parents and students, who are the main stakeholders in the transformation to a BYOD school. In this paper we analyse data gathered from these surveys, which consists…

  11. Bring Your Own Device (BYOD) Programs in the Classroom: Teacher Use, Equity, and Learning Tools (United States)

    Fincher, Derrel


    This study explores teacher perceptions of Bring Your Own Device (BYOD) programs in the classroom, with a focus on teacher use, student equity of access, and student ability to use their devices as learning tools. While one-to-one laptop programs (students assigned identical school-owned laptop or tablet) has an extensive body of literature behind…

  12. Bring-Your-Own-Device: Turning Cell Phones into Forces for Good (United States)

    Imazeki, Jennifer


    Over the last few years, classroom response systems (or "clickers") have become increasingly common. Although most systems require students to use a standalone handheld device, bring-your-own-device (BYOD) systems allow students to use devices they already own (e.g., a cell phone, tablet or laptop) to submit responses via text message or…

  13. Five Ways to Hack and Cheat with Bring-Your-Own-Device Electronic Examinations (United States)

    Dawson, Phillip


    Bring-your-own-device electronic examinations (BYOD e-exams) are a relatively new type of assessment where students sit an in-person exam under invigilated conditions with their own laptop. Special software restricts student access to prohibited computer functions and files, and provides access to any resources or software the examiner approves.…

  14. An Empirical Study towards Understanding User Acceptance of Bring Your Own Device (BYOD) in Higher Education (United States)

    Cheng, Gary; Guan, Yuanyuan; Chau, Juliana


    This paper discusses the findings of a research study investigating user acceptance of bring your own device (BYOD) practice to support teaching and learning in a Hong Kong university. Forty-four undergraduate students and two teachers participated in the study. To collect their ratings of agreement with respect to several BYOD-related issues,…

  15. The Wild-Card Character of "Bring Your Own:" A Panel Discussion (United States)

    Campbell, W. Gardner; Fitch, Megan; German, Robert F., Jr.; Hulvey, Dale; McIntosh, Keith; McPherson, Michael R.; O'Keefe, John


    Panelists on the front lines of higher education information technology share their thoughts on Bring Your Own Device (BYOD) and what it could mean for colleges and universities. Five questions were asked of each panelist. These were: (1) How strategically important to higher education is the BYOD phenomenon? Is it simply a passing fad? (2) Should…

  16. Take heart in an initiative aiming to bring universal healthcare to ...

    International Development Research Centre (IDRC) Digital Library (Canada)


    Take heart in an initiative aiming to bring universal healthcare to Pakistan. Heartfile has developed an innovative model of health financing that enrolls primarily public sector health facilities. December 04, 2017. Bano Bibi is 73 years old and she is raising her two young granddaughters alone. When her son died in 2005 ...

  17. Bringing Together Interactive Digital Storytelling with Tangible Interaction : Challenges and Opportunities

    NARCIS (Netherlands)

    Catala, Alejandro; Theune, Mariët; Sylla, Cristina; Ribeiro, Pedro; Nunes, Nuno; Oakley, Ian; Nisi, Valentina


    This workshop aims to explore challenges and potential opportunities in bringing interactive digital storytelling into the realm of tangible and embodied interaction. To this end, experts from both fields are invited to present and discuss their ideas. Besides fostering discussion and potential

  18. Ready for Robotics: Bringing Together the T and E of STEM in Early Childhood Teacher Education (United States)

    Bers, Marina Umaschi; Seddighin, Safoura; Sullivan, Amanda


    Prior work has shown that early childhood educators demonstrate a lack of knowledge and understanding about technology and engineering, and about developmentally appropriate pedagogical approaches to bring those disciplines into the classrooms. This paper reports a study in which 32 early childhood educators participated in an intensive three-day…

  19. Descendit ad [in] inferna:'A matter of no small moment in bringing ...

    African Journals Online (AJOL)

    This article endorses Calvin's conviction that the 'descendit ad inferna' of the Apostles' Creed is part of the 'summary of doctrine' and a matter of 'no small moment in bringing about redemption' (Calvin 1960:Inst. II, xvi, 8). The reason for this role, however, is not Calvin's metaphorical interpretation of the clause. Instead, the ...

  20. Clickers in the Flipped Classroom: Bring Your Own Device (BYOD) to Promote Student Learning (United States)

    Hung, Hsiu-Ting


    Flipped classrooms continue to grow in popularity across all levels of education. Following this pedagogical trend, the present study aimed to enhance the face-to-face instruction in flipped classrooms with the use of clickers. A game-like clicker application was implemented through a bring your own device (BYOD) model to gamify classroom dynamics…

  1. Contingent Commitments: Bringing Part-Time Faculty into Focus. Methodology Supplement (United States)

    Center for Community College Student Engagement, 2014


    Center reporting prior to 2013 focused primarily on descriptive statistics (frequencies and means) of student and faculty behaviors. The goal of the analyses reported here and in "Contingent Commitments: Bringing Part-Time Faculty into Focus" is to understand the engagement of part-time or contingent faculty in various activities that…

  2. Bring Your Own Device--A Snapshot of Two Australian Primary Schools (United States)

    Maher, Damian; Twining, Peter


    Background: The use of 1:1 and Bring Your Own Device strategies in schools is in its infancy and little is known about how mobile devices such as tablets are being used to support educational practice. Purpose: In this article, two suburban primary schools in Sydney, Australia were focused on with an aim to understand how mobile device strategies…

  3. Digital Natives: The Millennial Workforce's Intention to Adopt Bring Your Own Device (United States)

    Fulton, Joel


    Bring your own device (BYOD) is the use of uncontrolled devices, which increases risks to business data and intellectual property. Like centralized and distributed computing adoption before it, the rapid proliferation of BYOD has outstripped security advances. The trend is growing due to the expectations of the Millennial workforce and its high…

  4. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act. (United States)


    ... individual activities ordinarily constitute engagement in commerce or in the production of goods for commerce... REGULATIONS THE FAIR LABOR STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Employment to Which the... Production of Goods for Commerce § 779.110 Employees in retailing whose activities may bring them under the...

  5. Explore: An Action to Bring Science and Technology Closer to Secondary School (United States)

    Torras-Melenchon, Nuria; Grau, M. Dolors; Font-Soldevila, Josep; Freixas, Josep


    This paper presents the experience of an initiative, the EXPLORE courses, designed to bring science and technology closer to secondary school. The EXPLORE courses, organised by "EXPLORATORI: Natural Resources" project, are particularly addressed to secondary school teachers and are conducted at Catalonia (North East of Spain). The main…

  6. Bringing up condom use and using condoms with new sexual partners : Intentional or habitual?

    NARCIS (Netherlands)

    Yzer, M.C; Siero, F.W.; Buunk, Abraham (Bram)


    A prospective study of 94 Dutch adults who have casual sexual partners examined whether two important aspects of safe sex. namely bringing up condom use (BCU) and actual condom use (ACU) are intentional or habitual. For each of these aspects, a model based on the Theory of Planned Behaviour (TPB:

  7. Is the Process of Special Measures an Effective Tool for Bringing about Authentic School Improvement? (United States)

    Willis, Lynne


    Managing change in education is a complex process, but to do so under the pressure of a punishment-based measurement system (Fullan, 2008) makes sustainable and meaningful change increasingly difficult. Systems which produce high stakes accountability measures, which bring with it sanctions that create a greater sense of distrust, demoralization…

  8. Bringing Preschoolers and the Institutionalized Elderly Together: How One Program Works. (United States)

    Robbert, Lois

    In developing an intergenerational program bringing together preschool children and elderly adults in a retirement home/geriatric center complex, preschool staff had to discard three misconceptions. It was initially supposed that the elderly would like to visit the nursery school. It was assumed that people in the retirement home have nothing to…

  9. Crawl and crowd to bring machine translation to under-resourced languages

    NARCIS (Netherlands)

    Toral Ruiz, Antonio


    We present a widely applicable methodology to bring machine translation (MT) to under-resourced languages in a cost-effective and rapid manner. Our proposal relies on web crawling to automatically acquire parallel data to train statistical MT systems if any such data can be found for the language


    Directory of Open Access Journals (Sweden)

    Radu - Florin GEAMĂNU


    Full Text Available The study will try to perform an in-depth analysis of the measure of compulsory bringing, assessing both the national legislation and the legislation of some European countries, namely: Austria, Bulgaria, Poland and the Netherlands. Due attention will be granted to the provisions of the current Criminal Procedure Code, which entered into force on the 1st of February 2014, as this piece of legislation brings some important changes regarding the compulsory bringing, some of them being the consequence of the convictions of Romania in front of the Strasbourg Court. Also, the paper will focus on case-law established by the European Court of Human Rights regarding articles 3 and 5 relating to the compulsory bringing. To close with, the study will give some conclusions regarding the conformity of the current Criminal Procedure Code of Romania with the standards imposed by the European Convention for the Protection of Human Rights and Fundamental Freedoms and by the case-law of the European Court of Human Rights.

  11. Bringing Adam Smith's Pin Factory to Life: Field Trips and Discussions as Forms of Experiential Learning (United States)

    Galizzi, Monica


    Educators are often aware of the need to implement a variety of teaching techniques to reach out to students with different learning styles. I describe an attempt to target multimodal learners by bringing classical economic texts and concepts to life through discussions, field visits and role playing exercises. In my Labor Economics class I…

  12. A Mobile Farmers' Market Brings Nutrition Education to Low-Income Students (United States)

    Ellsworth, Devin; Ernst, Jenny; Snelling, Anastasia


    Purpose: The purpose of this paper is to examine the impact of a nutrition-education intervention delivered at low-income middle schools in Washington, DC in the USA, using a mobile farmers' market to bring hands-on lessons to schools. The program was a partnership between a local farm and university and was funded by the United States Department…

  13. Data Nuggets: Bringing Real Data into the Classroom to Unearth Students' Quantitative & Inquiry Skills (United States)

    Schultheis, Elizabeth H.; Kjelvik, Melissa K.


    Current educational reform calls for increased integration between science and mathematics to overcome the shortcomings in students' quantitative skills. Data Nuggets (free online resource, are worksheets that bring data into the classroom, repeatedly guiding students through the scientific method and making claims…

  14. The Power of Questions to Bring Balance to the Curriculum in the Age of New Standards (United States)

    del Prado, Pixita; McMillen, Susan E.; Friedland, Ellen S.


    The Common Core State Standards (CCSS); the Next Generation Science Standards (NGSS); and the College, Career, and Civic Life (C3) Framework for Social State Standards are bringing many changes to schools and classrooms across the United States. This article suggests using the power of questions to make connections across seemingly disparate…

  15. How Do Virtual World Experiences Bring about Learning? A Critical Review of Theories (United States)

    Loke, Swee-Kin


    While students do learn real-world knowledge and skills in virtual worlds, educators have yet to adequately theorise how students' virtual world experiences bring about this learning. This paper critically reviewed theories currently used to underpin empirical work in virtual worlds for education. In particular, it evaluated how applicable these…

  16. Nutritional Systems Biology: Definitions and Approaches

    DEFF Research Database (Denmark)

    Panagiotou, Gianni; Nielsen, Jens


    will benefit most from, or be placed at risk by, intervention strategies. More accurate assessment of the inputs to human health and the consequences of those inputs measured as accurate transcriptomic, proteomic, and metabolomic analyses would bring personalized health/diet to practice far faster than would...... waiting for a predictive knowledge of genetic variation. It is widely recognized that systems and network biology has the potential to increase our understanding of how nutrition influences metabolic pathways and homeostasis, how this regulation is disturbed in a diet-related disease, and to what extent...

  17. Knowledge Mobilization across Boundaries with the Use of Novel Organizational Structures, Conferencing Strategies, and Technological Tools: The Ontario Consortium of Undergraduate Biology Educators (oCUBE) Model (United States)

    Kajiura, Lovaye; Smit, Julie; Montpetit, Colin; Kelly, Tamara; Waugh, Jennifer; Rawle, Fiona; Clark, Julie; Neumann, Melody; French, Michelle


    The Ontario Consortium of Undergraduate Biology Educators (oCUBE) brings together over 50 biology educators from 18 Ontario universities with the common goal to improve the biology undergraduate experience for both students and educators. This goal is achieved through an innovative mix of highly interactive face-to-face meetings, online…

  18. Possible room temperature superconductivity in conductors obtained by bringing alkanes into contact with a graphite surface (United States)

    Kawashima, Yasushi


    Electrical resistances of conductors obtained by bringing alkanes into contact with a graphite surface have been investigated at room temperatures. Ring current in a ring-shaped container into which n-octane-soaked thin graphite flakes were compressed did not decay for 50 days at room temperature. After two HOPG plates were immersed into n-heptane and n-octane at room temperature, changes in resistances of the two samples were measured by four terminal technique. The measurement showed that the resistances of these samples decrease to less than the smallest resistance that can be measured with a high resolution digital voltmeter (0.1μV). The observation of persistent currents in the ring-shaped container suggests that the HOPG plates immersed in n-heptane and n-octane really entered zero-resistance state at room temperature. These results suggest that room temperature superconductor may be obtained by bringing alkanes into contact with a graphite surface.

  19. Bring's Curve: its Period Matrix and the Vector of Riemann Constants (United States)

    Braden, Harry W.; Northover, Timothy P.


    Bring's curve is the genus 4 Riemann surface with automorphism group of maximal size, S5. Riera and Rodríguez have provided the most detailed study of the curve thus far via a hyperbolic model. We will recover and extend their results via an algebraic model based on a sextic curve given by both Hulek and Craig and implicit in work of Ramanujan. In particular we recover their period matrix; further, the vector of Riemann constants will be identified.

  20. Cross-Platform Development : Bringing a desktop web application to the mobile platform


    Tengroth, Wiktor


    Cross-platform development frameworks make it possible to develop web applications for multiple platforms with just one code-base. The aim of this thesis is to determine which kind of framework is best suited to bring a web application targeting desktop browsers to the mobile platform. This includes being able to use already developed web components. The evalutation was done by first selecting six frameworks from two different choices of cross-platform technologies. Then a literature study wa...

  1. An Internet Framework to Bring Coherence between WAP and HTTP Ensuring Better Mobile Internet Security


    Pathan, Al-Mukaddim Khan; Mottalib, Md. Abdul; Zibran, Minhaz Fahim


    To bring coherence between Wireless Access Protocol (WAP) and Hyper Text Transfer Protocol (HTTP), in this paper, we have proposed an enhanced Internet framework, which incorporates a new markup language and a browser compatible with both of the access control protocols. This Markup Language and the browser enables co-existence of both Hyper Text Markup Language (HTML) and Wireless Markup Language (WML) contents in a single source file, whereas the browser incorporates the ability to hold con...

  2. On the search for design principles in biological systems. (United States)

    Poyatos, Juan F


    The search for basic concepts and underlying principles was at the core of the systems approach to science and technology. This approach was somehow abandoned in mainstream biology after its initial proposal, due to the rise and success of molecular biology. This situation has changed. The accumulated knowledge of decades of molecular studies in combination with new technological advances, while further highlighting the intricacies of natural systems, is also bringing back the quest-for-principles research program. Here, I present two lessons that I derived from my own quest: the importance of studying biological information processing to identify common principles in seemingly unrelated contexts and the adequacy of using known design principles at one level of biological organization as a valuable tool to help recognizing principles at an alternative one. These and additional lessons should contribute to the ultimate goal of establishing principles able to integrate the many scales of biological complexity.

  3. Intellectual pursuits of Nicolas Rashevsky the queer duck of biology

    CERN Document Server

    Shmailov, Maya M


    Who was Nicolas Rashevsky? To answer that question, this book draws on Rashevsky’s unexplored personal archival papers and shares interviews with his family, students and friends, as well as discussions with biologists and mathematical biologists, to flesh out and complete the picture. “Most modern-day biologists have never heard of Rashevsky. Why?” In what constitutes the first detailed biography of theoretical physicist Nicolas Rashevsky (1899-1972), spanning key aspects of his long scientific career, the book captures Rashevsky’s ways of thinking about the place mathematical biology should have in biology and his personal struggle for the acceptance of his views. It brings to light the tension between mathematicians, theoretical physicists and biologists when it comes to the introduction of physico-mathematical tools into biology. Rashevsky’s successes and failures in his efforts to establish mathematical biology as a subfield of biology provide an important test case for understanding the role o...

  4. The Eighth Central European Conference "Chemistry towards Biology": Snapshot. (United States)

    Perczel, András; Atanasov, Atanas G; Sklenář, Vladimír; Nováček, Jiří; Papoušková, Veronika; Kadeřávek, Pavel; Žídek, Lukáš; Kozłowski, Henryk; Wątły, Joanna; Hecel, Aleksandra; Kołkowska, Paulina; Koča, Jaroslav; Svobodová-Vařeková, Radka; Pravda, Lukáš; Sehnal, David; Horský, Vladimír; Geidl, Stanislav; Enriz, Ricardo D; Matějka, Pavel; Jeništová, Adéla; Dendisová, Marcela; Kokaislová, Alžběta; Weissig, Volkmar; Olsen, Mark; Coffey, Aidan; Ajuebor, Jude; Keary, Ruth; Sanz-Gaitero, Marta; van Raaij, Mark J; McAuliffe, Olivia; Waltenberger, Birgit; Mocan, Andrei; Šmejkal, Karel; Heiss, Elke H; Diederich, Marc; Musioł, Robert; Košmrlj, Janez; Polański, Jarosław; Jampílek, Josef


    The Eighth Central European Conference "Chemistry towards Biology" was held in Brno, Czech Republic, on August 28-September 1, 2016 to bring together experts in biology, chemistry and design of bioactive compounds; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topics of the conference covered "Chemistry towards Biology", meaning that the event welcomed chemists working on biology-related problems, biologists using chemical methods, and students and other researchers of the respective areas that fall within the common scope of chemistry and biology. The authors of this manuscript are plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting.

  5. A framework for evolutionary systems biology. (United States)

    Loewe, Laurence


    Many difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often simple to predict. Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe small effects. Here I propose a novel framework that brings together evolutionary theory and current systems biology approaches in order to quantify small effects of mutations and their epistatic interactions in silico. Central to this approach is the definition of fitness correlates that can be computed in some current systems biology models employing the rigorous algorithms that are at the core of much work in computational systems biology. The framework exploits synergies between the realism of such models and the need to understand real systems in evolutionary theory. This framework can address many longstanding topics in evolutionary biology by defining various 'levels' of the adaptive landscape. Addressed topics include the distribution of mutational effects on fitness, as well as the nature of advantageous mutations, epistasis and robustness. Combining corresponding parameter estimates with population genetics models raises the possibility of testing evolutionary hypotheses at a new level of realism. EvoSysBio is expected to lead to a more detailed understanding of the fundamental principles of life by combining knowledge about well-known biological systems from several disciplines. This will benefit both evolutionary theory and current systems biology. Understanding robustness by analysing distributions of mutational effects and epistasis is pivotal for drug design, cancer research, responsible genetic engineering in synthetic biology and many other practical applications.

  6. A framework for evolutionary systems biology

    Directory of Open Access Journals (Sweden)

    Loewe Laurence


    Full Text Available Abstract Background Many difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often simple to predict. Current systems biology has accumulated much data on mutations with large effects and can predict the properties of knockout mutants in some systems. However experimental methods are too insensitive to observe small effects. Results Here I propose a novel framework that brings together evolutionary theory and current systems biology approaches in order to quantify small effects of mutations and their epistatic interactions in silico. Central to this approach is the definition of fitness correlates that can be computed in some current systems biology models employing the rigorous algorithms that are at the core of much work in computational systems biology. The framework exploits synergies between the realism of such models and the need to understand real systems in evolutionary theory. This framework can address many longstanding topics in evolutionary biology by defining various 'levels' of the adaptive landscape. Addressed topics include the distribution of mutational effects on fitness, as well as the nature of advantageous mutations, epistasis and robustness. Combining corresponding parameter estimates with population genetics models raises the possibility of testing evolutionary hypotheses at a new level of realism. Conclusion EvoSysBio is expected to lead to a more detailed understanding of the fundamental principles of life by combining knowledge about well-known biological systems from several disciplines. This will benefit both evolutionary theory and current systems biology. Understanding robustness by analysing distributions of mutational effects and epistasis is pivotal for drug design, cancer research, responsible genetic engineering in synthetic biology and many other practical applications.

  7. Architecture for interoperable software in biology. (United States)

    Bare, James Christopher; Baliga, Nitin S


    Understanding biological complexity demands a combination of high-throughput data and interdisciplinary skills. One way to bring to bear the necessary combination of data types and expertise is by encapsulating domain knowledge in software and composing that software to create a customized data analysis environment. To this end, simple flexible strategies are needed for interconnecting heterogeneous software tools and enabling data exchange between them. Drawing on our own work and that of others, we present several strategies for interoperability and their consequences, in particular, a set of simple data structures--list, matrix, network, table and tuple--that have proven sufficient to achieve a high degree of interoperability. We provide a few guidelines for the development of future software that will function as part of an interoperable community of software tools for biological data analysis and visualization. © The Author 2012. Published by Oxford University Press.

  8. Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything

    DEFF Research Database (Denmark)

    Taudal Poulsen, René


    Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639......Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639...

  9. 24 CFR 103.30 - How should I bring a claim that I am the victim of discrimination? (United States)


    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false How should I bring a claim that I am the victim of discrimination? 103.30 Section 103.30 Housing and Urban Development Regulations... How should I bring a claim that I am the victim of discrimination? (a) You can file a claim by mail or...

  10. 36 CFR 1280.8 - May I bring a seeing-eye dog or other assistance animal? (United States)


    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false May I bring a seeing-eye dog or other assistance animal? 1280.8 Section 1280.8 Parks, Forests, and Public Property NATIONAL... dog or other assistance animal? Yes, persons with disabilities may bring guide dogs or other animals...

  11. Dyneins: structure, biology and disease

    National Research Council Canada - National Science Library

    King, Stephen M


    .... From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine...

  12. Biological conversion system (United States)

    Scott, C.D.

    A system for bioconversion of organic material comprises a primary bioreactor column wherein a biological active agent (zymomonas mobilis) converts the organic material (sugar) to a product (alcohol), a rejuvenator column wherein the biological activity of said biological active agent is enhanced, and means for circulating said biological active agent between said primary bioreactor column and said rejuvenator column.

  13. Translational environmental biology: cell biology informing conservation. (United States)

    Traylor-Knowles, Nikki; Palumbi, Stephen R


    Typically, findings from cell biology have been beneficial for preventing human disease. However, translational applications from cell biology can also be applied to conservation efforts, such as protecting coral reefs. Recent efforts to understand the cell biological mechanisms maintaining coral health such as innate immunity and acclimatization have prompted new developments in conservation. Similar to biomedicine, we urge that future efforts should focus on better frameworks for biomarker development to protect coral reefs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Synthetic biology: insights into biological computation. (United States)

    Manzoni, Romilde; Urrios, Arturo; Velazquez-Garcia, Silvia; de Nadal, Eulàlia; Posas, Francesc


    Organisms have evolved a broad array of complex signaling mechanisms that allow them to survive in a wide range of environmental conditions. They are able to sense external inputs and produce an output response by computing the information. Synthetic biology attempts to rationally engineer biological systems in order to perform desired functions. Our increasing understanding of biological systems guides this rational design, while the huge background in electronics for building circuits defines the methodology. In this context, biocomputation is the branch of synthetic biology aimed at implementing artificial computational devices using engineered biological motifs as building blocks. Biocomputational devices are defined as biological systems that are able to integrate inputs and return outputs following pre-determined rules. Over the last decade the number of available synthetic engineered devices has increased exponentially; simple and complex circuits have been built in bacteria, yeast and mammalian cells. These devices can manage and store information, take decisions based on past and present inputs, and even convert a transient signal into a sustained response. The field is experiencing a fast growth and every day it is easier to implement more complex biological functions. This is mainly due to advances in in vitro DNA synthesis, new genome editing tools, novel molecular cloning techniques, continuously growing part libraries as well as other technological advances. This allows that digital computation can now be engineered and implemented in biological systems. Simple logic gates can be implemented and connected to perform novel desired functions or to better understand and redesign biological processes. Synthetic biological digital circuits could lead to new therapeutic approaches, as well as new and efficient ways to produce complex molecules such as antibiotics, bioplastics or biofuels. Biological computation not only provides possible biomedical and

  15. Synthetic Biology-The Synthesis of Biology. (United States)

    Ausländer, Simon; Ausländer, David; Fussenegger, Martin


    Synthetic biology concerns the engineering of man-made living biomachines from standardized components that can perform predefined functions in a (self-)controlled manner. Different research strategies and interdisciplinary efforts are pursued to implement engineering principles to biology. The "top-down" strategy exploits nature's incredible diversity of existing, natural parts to construct synthetic compositions of genetic, metabolic, or signaling networks with predictable and controllable properties. This mainly application-driven approach results in living factories that produce drugs, biofuels, biomaterials, and fine chemicals, and results in living pills that are based on engineered cells with the capacity to autonomously detect and treat disease states in vivo. In contrast, the "bottom-up" strategy seeks to be independent of existing living systems by designing biological systems from scratch and synthesizing artificial biological entities not found in nature. This more knowledge-driven approach investigates the reconstruction of minimal biological systems that are capable of performing basic biological phenomena, such as self-organization, self-replication, and self-sustainability. Moreover, the syntheses of artificial biological units, such as synthetic nucleotides or amino acids, and their implementation into polymers inside living cells currently set the boundaries between natural and artificial biological systems. In particular, the in vitro design, synthesis, and transfer of complete genomes into host cells point to the future of synthetic biology: the creation of designer cells with tailored desirable properties for biomedicine and biotechnology. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Somali Parents' Experiences of Bringing up Children in Finland: Exploring Social-Cultural Change within Migrant Households

    Directory of Open Access Journals (Sweden)

    Filio Degni


    Full Text Available Approximately 5,000 to 6,000 Somalis arrived in Finland between 1990 and 1995 through Russia. Currently, 8,096 have settled permanently in the country. The data reported here is from a 1998-1999 research survey carried out in the Finish cities of Helsinki and Turku. The survey of 117 married Somalis explored the social-cultural determinants of contraception use. The paper presented here focuses upon one particular aspect of the survey. We selected 21 Somali parents (11 women and 10 men to look in-depth at the experiences of Somali migrants raising children in Finland. All of the respondents selected have more than 5 children in their family and all were asked to describe their experiences of raising children in Finland and, more generally, in establishing and maintaining family structures. Unlike their experiences in Somali, bringing up large families (by Westerns standards is not a collective matter in Finland where biological parents are left to manage the family for themselves. A number of challenges also accompany this shift in family norms: first, and most notably, there is the need to re-establish control over one's life in an alien environment; second, intergenerational conflict between adult migrants and their adolescent children is often heightened. The findings indicate that Somalis' experiences of raising children in Finland raise important parenting challenges associated with changing generational, gender and family relations within the migrant household. Importantly, this case study of large Somali families shows how migrants' lives are intricately linked to the household dynamic between home and host country. URN: urn:nbn:de:0114-fqs060388

  17. Cdc48: A Swiss Army Knife of Cell Biology

    Directory of Open Access Journals (Sweden)

    Guem Hee Baek


    Full Text Available Cdc48 (also called VCP and p97 is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis, studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.

  18. The ‘added value’ GPs bring to commissioning: a qualitative study in primary care (United States)

    Perkins, Neil; Coleman, Anna; Wright, Michael; Gadsby, Erica; McDermott, Imelda; Petsoulas, Christina; Checkland, Kath


    Background The 2012 Health and Social Care Act in England replaced primary care trusts with clinical commissioning groups (CCGs) as the main purchasing organisations. These new organisations are GP-led, and it was claimed that this increased clinical input would significantly improve commissioning practice. Aim To explore some of the key assumptions underpinning CCGs, and to examine the claim that GPs bring ‘added value’ to commissioning. Design and setting In-depth interviews with clinicians and managers across seven CCGs in England between April and September 2013. Method A total of 40 clinicians and managers were interviewed. Interviews focused on the perceived ‘added value’ that GPs bring to commissioning. Results Claims to GP ‘added value’ centred on their intimate knowledge of their patients. It was argued that this detailed and concrete knowledge improves service design and that a close working relationship between GPs and managers strengthens the ability of managers to negotiate. However, responders also expressed concerns about the large workload that they face and about the difficulty in engaging with the wider body of GPs. Conclusion GPs have been involved in commissioning in many ways since fundholding in the 1990s, and claims such as these are not new. The key question is whether these new organisations better support and enable the effective use of this knowledge. Furthermore, emphasis on experiential knowledge brings with it concerns about representativeness and the extent to which other voices are heard. Finally, the implicit privileging of GPs’ personal knowledge ahead of systematic public health intelligence also requires exploration. PMID:25348997

  19. Virtual Reality: Bringing the Awe of Our Science into The Classroom with VR (United States)

    Bell, R. E.; Turrin, M.; Frearson, N.; Boghosian, A.; Ferrini, V. L.; Simpson, F.


    The geosciences are rich in imagery, making them compelling material for immersive teaching experiences. We often work in remote locations, places where few others are able to travel. Flat 2 D images from the field have served explorers and scientists well from the lantern slides brought back from Antarctica to the images scientists and educators now use in powerpoint presentations. These images provide a backdrop to introduce the experience for formal classes and informal presentations. Our stories from the field bring the setting alive for the participants. The travelers presented and the audience passively listened. Immersive learning opportunities are much more powerful than lecturing. We have enlisted both VR and drone imagery to bring learners fully into the experience of science. A 360 VR image brings the viewer into the moment of discovery. Both have been shown to create an active learning setting fully under the learner's control; they explore at their own pace and following their own interest. This learning `sticks', becoming part of the participant's own unique experience in the space. We are building VR images of field experiences and VR data immersion experiences that will transport people into new locations, building a field experience that they can not only see but fully explore. Through VR we introduce new experiences that showcase our science, our careers and our collaborations. Users can spin the view up to see the helicopter landing in a remote field location by the ice. Spin to the right and see a colleague collecting a reading from instruments that have been pulled from the LC130 aircraft. Turn the view to the left and see the harsh windswept environment along the edge of an ice shelf. Look down and note that you feet are encased in snow boots to keep them warm and stable on the ice. The viewer is in the field as part of the science team. Learning in the classroom and through social media is now fully 360 and fully immersive.

  20. Perspectives on mathematical practices bringing together philosophy of mathematics, sociology of mathematics, and mathematics education

    CERN Document Server

    van Kerkhove, Bart


    Philosophy of mathematics today has transformed into a very complex network of diverse ideas, viewpoints, and theories. Sometimes the emphasis is on the ""classical"" foundational work (often connected with the use of formal logical methods), sometimes on the sociological dimension of the mathematical research community and the ""products"" it produces, then again on the education of future mathematicians and the problem of how knowledge is or should be transmitted from one generation to the next. The editors of this book felt the urge, first of all, to bring together the widest variety of aut

  1. Bring's Curve: its Period Matrix and the Vector of Riemann Constants

    Directory of Open Access Journals (Sweden)

    Harry W. Braden


    Full Text Available Bring's curve is the genus 4 Riemann surface with automorphism group of maximal size, S_5. Riera and Rodríguez have provided the most detailed study of the curve thus far via a hyperbolic model. We will recover and extend their results via an algebraic model based on a sextic curve given by both Hulek and Craig and implicit in work of Ramanujan. In particular we recover their period matrix; further, the vector of Riemann constants will be identified.

  2. Patents: a tool to bring innovation from the lab bench to the marketplace. (United States)

    Li, Z Ying; Meyer, Wolfram


    Intellectual property (IP) is creations of the mind. Protecting IP through patents is an important venue for a researcher to reap rewards from his scientific endeavors. It is part of a competitive strategy for bringing one's invention to the marketplace. Using the US and European patent systems as examples, we provide here an overview of how patents protect innovation, with a focus on biotechnology. We explain what a patent is, what a patent owner can do with a patent, and how patents are granted. The article ends with some recent examples of noteworthy patents in the field of yeast research.

  3. Old Books Bring New Life to the Brick and Mortar Library (United States)

    Bosken, S.


    If all the library books and journals can be viewed on your desk top, why come to the physical library? The USNO Library tried to bring the patrons inside the library. One method was to rotate rare book displays each month. As the library holds a fabulous collection of ancient astronomy books, including Copernicus, Kepler, Galileo, and Newton, we have abundant resources. The presentation will highlight the varied displays and offer a Rare Books 101 explanation of paper, printing, binding and a behind-the-scenes look at how old books are maintained and preserved.

  4. "Bringing Taxonomy to the Service of Genetics": Edgar Anderson and Introgressive Hybridization. (United States)

    Kleinman, Kim


    In introgressive hybridization (the repeated backcrossing of hybrids with parental populations), Edgar Anderson found a source for variation upon which natural selection could work. In his 1953 review article "Introgressive Hybridization," he asserted that he was "bringing taxonomy to the service of genetics" whereas distinguished colleagues such as Theodosius Dobzhansky and Ernst Mayr did the precise opposite. His work as a geneticist particularly focused on linkage and recombination and was enriched by collaborations with Missouri Botanical Garden colleagues interested in taxonomy as well as with cytologists C.D. Darlington and Karl Sax. As the culmination of a biosystemtatic research program, Anderson's views challenged the mainstream of the Evolutionary Synthesis.

  5. Bringing science to bear--on peace, not war: elaborating on psychology's potential to promote peace. (United States)

    Leidner, Bernhard; Tropp, Linda R; Lickel, Brian


    We argue that psychological and contextual factors play important roles in bringing about, facilitating, and escalating violent conflict. Yet rather than conclude that violent conflict is inevitable, we believe psychology's contributions can extend beyond understanding the origins and nature of violent conflict, to promote nonviolence and peace. In this article, we summarize psychological perspectives on the conditions and motivations underlying violent conflict. Drawing on this work, we then discuss psychological and contextual factors that can mitigate violence and war and promote nonviolence and peace. PsycINFO Database Record (c) 2013 APA, all rights reserved

  6. BioVersys Works to Bring Antibiotic Resistance to an End. (United States)

    Tigges, Marcel; Gitzinger, Marc


    BioVersys, founded in 2008, is working on bringing a technology for screening and for the development of 'transcriptional regulator inhibiting compounds' (TRICs) to patients in order to overcome antibiotic resistance. The co-founders share their view on what makes successful scientists pursue a career as start-up entrepreneurs rather than a classic academic career. They describe the history and milestones of their company, and how their everyday work differs from that of peers in an academic or industrial research setting.

  7. [Bring fruit at school: promotion of healthy food habit in primary school-children]. (United States)

    Panunzio, M F; Antoniciello, A; Ugolini, G; Dalton, S


    The many nutrition education guidelines formulated by different organizations and institutions are the frames for the program actions targeting nutrition awareness in the school-age population. But while the guidelines represent a solid starting block they still need to be backed up by programs giving concrete form to the guiding principles, a program whose efficacy is demonstrated by specific applications studies. The aim of the "Bring Fruit at School" nutrition education program is to encourage elementary school children to change their eating habits for the better. And in particular to eat more fruit, vegetables, legumes, and fish and to cut down on junk-food and sugar-sweetened drink.

  8. Strategies of bringing drug product marketing applications to meet current regulatory standards. (United States)

    Wu, Yan; Freed, Anita; Lavrich, David; Raghavachari, Ramesh; Huynh-Ba, Kim; Shah, Ketan; Alasandro, Mark


    In the past decade, many guidance documents have been issued through collaboration of global organizations and regulatory authorities. Most of these are applicable to new products, but there is a risk that currently marketed products will not meet the new compliance standards during audits and inspections while companies continue to make changes through the product life cycle for continuous improvement or market demands. This discussion presents different strategies to bringing drug product marketing applications to meet current and emerging standards. It also discusses stability and method designs to meet process validation and global development efforts.

  9. Bringing Evidence-Based Practice to Latin America: Transforming Nursing Education and Practice. (United States)

    Visovsky, Constance; Maguire, Denise J; Zambroski, Cheryl; Palacios, Linette


    Evidence-based practice (EBP) continues to gain global attention. In the Latin American country of Panama, nursing practice has largely been guided by oral tradition and clinical experience rather than the use of best evidence. The authors used a conference-based approach in a joint effort between the University of South Florida and the University of Panama to introduce EBP to nursing leaders in Panama to bring change to the nursing curricula and, ultimately, change in nursing practice. J Contin Educ Nurs. 2017;48(11):512-516. Copyright 2017, SLACK Incorporated.

  10. International Conference on Intelligent Systems for Molecular Biology (ISMB)

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, Debra; Hibbs, Matthew; Kall, Lukas; Komandurglayavilli, Ravikumar; Mahony, Shaun; Marinescu, Voichita; Mayrose, Itay; Minin, Vladimir; Neeman, Yossef; Nimrod, Guy; Novotny, Marian; Opiyo, Stephen; Portugaly, Elon; Sadka, Tali; Sakabe, Noboru; Sarkar, Indra; Schaub, Marc; Shafer, Paul; Shmygelska, Olena; Singer, Gregory; Song, Yun; Soumyaroop, Bhattacharya; Stadler, Michael; Strope, Pooja; Su, Rong; Tabach, Yuval; Tae, Hongseok; Taylor, Todd; Terribilini, Michael; Thomas, Asha; Tran, Nam; Tseng, Tsai-Tien; Vashist, Akshay; Vijaya, Parthiban; Wang, Kai; Wang, Ting; Wei, Lai; Woo, Yong; Wu, Chunlei; Yamanishi, Yoshihiro; Yan, Changhui; Yang, Jack; Yang, Mary; Ye, Ping; Zhang, Miao


    The Intelligent Systems for Molecular Biology (ISMB) conference has provided a general forum for disseminating the latest developments in bioinformatics on an annual basis for the past 13 years. ISMB is a multidisciplinary conference that brings together scientists from computer science, molecular biology, mathematics and statistics. The goal of the ISMB meeting is to bring together biologists and computational scientists in a focus on actual biological problems, i.e., not simply theoretical calculations. The combined focus on "intelligent systems" and actual biological data makes ISMB a unique and highly important meeting, and 13 years of experience in holding the conference has resulted in a consistently well organized, well attended, and highly respected annual conference. The ISMB 2005 meeting was held June 25-29, 2005 at the Renaissance Center in Detroit, Michigan. The meeting attracted over 1,730 attendees. The science presented was exceptional, and in the course of the five-day meeting, 56 scientific papers, 710 posters, 47 Oral Abstracts, 76 Software demonstrations, and 14 tutorials were presented. The attendees represented a broad spectrum of backgrounds with 7% from commercial companies, over 28% qualifying for student registration, and 41 countries were represented at the conference, emphasizing its important international aspect. The ISMB conference is especially important because the cultures of computer science and biology are so disparate. ISMB, as a full-scale technical conference with refereed proceedings that have been indexed by both MEDLINE and Current Contents since 1996, bridges this cultural gap.

  11. II. Biological studies of radiation effects

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, J.H.


    With the completion of the 184 inch cyclotron in Berkeley and the successful construction of a deflector system, it was possible to bring the 190 Mev deuteron and the 380 Mev alpha beams out into the air and to begin a study of the effects of high-energy deuteron beams by direct irradiation of biological specimens. The direct biological use of deuteron beams was attempted earlier in Berkeley by Marshak, MacLeish, and Walker in 1940. These and other investigators have been aware for some time of the potential usefulness of high energy particle beams for radio-biological studies and their suitability for biological investigations. R.R. Wilson advanced the idea of using fast proton beams to deliver radiation and intervening tissues. R.E. Zirkle pointed out that such particle beams may be focused or screened until a cross-section of the beam is small enough to study effects of irradiation under the microscope on single cells or on parts of single cells. This article gives an overview of the radiological use of high energy deuteron beams, including the following topics: potential uses of high energy particle beams; experiments on the physical properties of the beam; lethal effect of the deuteron beam on mice.

  12. Using Raman spectroscopy to characterize biological materials. (United States)

    Butler, Holly J; Ashton, Lorna; Bird, Benjamin; Cinque, Gianfelice; Curtis, Kelly; Dorney, Jennifer; Esmonde-White, Karen; Fullwood, Nigel J; Gardner, Benjamin; Martin-Hirsch, Pierre L; Walsh, Michael J; McAinsh, Martin R; Stone, Nicholas; Martin, Francis L


    Raman spectroscopy can be used to measure the chemical composition of a sample, which can in turn be used to extract biological information. Many materials have characteristic Raman spectra, which means that Raman spectroscopy has proven to be an effective analytical approach in geology, semiconductor, materials and polymer science fields. The application of Raman spectroscopy and microscopy within biology is rapidly increasing because it can provide chemical and compositional information, but it does not typically suffer from interference from water molecules. Analysis does not conventionally require extensive sample preparation; biochemical and structural information can usually be obtained without labeling. In this protocol, we aim to standardize and bring together multiple experimental approaches from key leaders in the field for obtaining Raman spectra using a microspectrometer. As examples of the range of biological samples that can be analyzed, we provide instructions for acquiring Raman spectra, maps and images for fresh plant tissue, formalin-fixed and fresh frozen mammalian tissue, fixed cells and biofluids. We explore a robust approach for sample preparation, instrumentation, acquisition parameters and data processing. By using this approach, we expect that a typical Raman experiment can be performed by a nonspecialist user to generate high-quality data for biological materials analysis.

  13. Models for synthetic biology

    Directory of Open Access Journals (Sweden)

    Kaznessis Yiannis N


    Full Text Available Abstract Synthetic biological engineering is emerging from biology as a distinct discipline based on quantification. The technologies propelling synthetic biology are not new, nor is the concept of designing novel biological molecules. What is new is the emphasis on system behavior. The objective is the design and construction of new biological devices and systems to deliver useful applications. Numerous synthetic gene circuits have been created in the past decade, including bistable switches, oscillators, and logic gates, and possible applications abound, including biofuels, detectors for biochemical and chemical weapons, disease diagnosis, and gene therapies. More than fifty years after the discovery of the molecular structure of DNA, molecular biology is mature enough for real quantification that is useful for biological engineering applications, similar to the revolution in modeling in chemistry in the 1950s. With the excitement that synthetic biology is generating, the engineering and biological science communities appear remarkably willing to cross disciplinary boundaries toward a common goal.

  14. Fuel cells for vehicle applications in cars - bringing the future closer (United States)

    Panik, Ferdinand

    Among all alternative drive systems, the fuel cell electric propulsion system has the highest potential to compete with the internal combustion engine. For this reason, Daimler-Benz AG has entered into a co-operative alliance with Ballard Power Systems, with the objectives of bringing fuel cell vehicles to the market. Apart from the fuel cell itself, fuel cell vehicles require comprehensive system technology to provide fuel and air supply, cooling, energy management, electric and electronic functions. The system technology determines to a large extent the cost, weight, efficiency, performance and overall customer benefit of fuel cell vehicles. Hence, Daimler-Benz and Ballard are pooling their expertise in fuel cell system technology in a joint company, with the aim of bringing their fuel cell vehicular systems to the stage of maturity required for market entry as early as possible. Hydrogen-fuelled zero-emission fuel cell transit `buses' will be the first market segment addressed, with an emphasis on the North American and European markets. The first buses are already scheduled for delivery to customers in late 1997. Since a liquid fuel like methanol is easier to handle in passenger cars, fuel reforming technologies are developed and will shortly be demonstrated in a prototype, as well. The presentation will cover concepts of fuel cell vehicles with an emphasis on system technology, the related testing procedures and results as well as an outline of market entry strategies.

  15. The Commonwealth Games as an Example of Bringing States Closer Through Sport

    Directory of Open Access Journals (Sweden)

    Kobierecki Michał Marcin


    Full Text Available The aim of the article is to investigate the issue of positive sports diplomacy directed at bringing countries closer and deepening cooperation between them. Generally, sports diplomacy is a broader term and may include various ways of utilizing sport, both negative and positive, even for the sake of nation-branding. Positive sports diplomacy most commonly refers to bringing hostile states closer together, but it may also be used to deepen political alliances or foster friendship and cooperation between states that are not mutually hostile. The research focuses on the latter form of positive sports diplomacy. The investigation is a case study concerning the Commonwealth Games, a sports event that is held once every four years and gathers countries and territories that used to belong to the former British Empire. The research therefore aims to determine whether this event, the second largest multisport event in the world, is significant from political and diplomatic perspectives. A second research question concerns whether the Commonwealth Games should be seen as an attempt by Great Britain to maintain influence in its former colonies. The research attempts to test the hypothesis that the Commonwealth Games are an important contributor to sustaining ties between states of the former British Empire.

  16. Possible room temperature superconductivity in conductors obtained by bringing alkanes into contact with a graphite surface

    Directory of Open Access Journals (Sweden)

    Yasushi Kawashima


    Full Text Available Electrical resistances of conductors obtained by bringing alkanes into contact with a graphite surface have been investigated at room temperatures. Ring current in a ring-shaped container into which n-octane-soaked thin graphite flakes were compressed did not decay for 50 days at room temperature. After two HOPG plates were immersed into n-heptane and n-octane at room temperature, changes in resistances of the two samples were measured by four terminal technique. The measurement showed that the resistances of these samples decrease to less than the smallest resistance that can be measured with a high resolution digital voltmeter (0.1μV. The observation of persistent currents in the ring-shaped container suggests that the HOPG plates immersed in n-heptane and n-octane really entered zero-resistance state at room temperature. These results suggest that room temperature superconductor may be obtained by bringing alkanes into contact with a graphite surface.

  17. Biological basis of detoxication

    National Research Council Canada - National Science Library

    Caldwell, John; Jakoby, William B


    This volume considers that premise that most of the major patterns of biological conversion of foreign compounds are known and may have predictive value in assessing the biological course for novel compounds...

  18. Biology of Blood (United States)

    ... switch to the Professional version Home Blood Disorders Biology of Blood Overview of Blood Resources In This ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  19. Marine mammals: evolutionary biology

    National Research Council Canada - National Science Library

    Berta, Annalisa; Sumich, James L; Kovacs, Kit M


    The third edition of Marine Mammals: Evolutionary Biology provides a comprehensive and current assessment of the diversity, evolution, and biology of marine mammals, while highlighting the latest tools and techniques for their study...

  20. A Skype-Buddy Model for Blended Learning (United States)

    Macharaschwili, Carmen E.; Coggin, Linda Skidmore


    Online learning in higher education allows distance education students to complete degree requirements in virtual environments. Universities are challenged with providing quality education experiences for these students and meet the students' needs for engagement and challenge within a collaborative framework. This study proposes how Voice over…

  1. Technologically Enhanced Archival Collections: Using the Buddy System (United States)

    Holz, Dayna


    Based in the context of challenges faced by archives when managing digital projects, this article explores options of looking outside the existing expertise of archives staff to find collaborative partners. In teaming up with other departments and organizations, the potential scope of traditional archival digitization projects is expanded beyond…

  2. Learning with Charlie: A robot buddy for children with diabetes

    NARCIS (Netherlands)

    Blanson Henkemans, O.A.; Pal, S.M. van der; Werner, I.; Looije, R.; Neericnx, M.A.


    Children with type 1 diabetes mellitus (T1DM) have a need for social, cognitive and affective support for self-management. The PAL project develops a social robot and its avatar. The aim is to assist the child, health care professional and parents to jointly perform diabetes management. Diabetes

  3. Yeast buddies helping to unravel the complexity of neurodegenerative disorders. (United States)

    Fruhmann, Gernot; Seynnaeve, David; Zheng, Ju; Ven, Karen; Molenberghs, Sofie; Wilms, Tobias; Liu, Beidong; Winderickx, Joris; Franssens, Vanessa


    Neurodegenerative disorders have a profound effect on the quality of life of patients and their environment. However, the development of adequate therapies requires accurate understanding of the underlying disease pathogenesis. On that account, yeast models can play an important role, as they enable the elucidation of the mechanisms leading to neurodegenerative disorders. Furthermore, by using so-called humanized yeast systems, the findings in yeast can be interpolated to humans. In this review, we will give an overview of the current body of knowledge on the use of yeast models with regard to Huntington's, Parkinson's and Alzheimer's disease. In addition to the results, obtained with the baker's yeast Saccharomyces cerevisiae, we also consider the existing literature on the less common but promising fission yeast Schizosaccharomyces pombe. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Building Consensus in Science: Resources for Intertextual Dialog in Biology Research Articles (United States)

    Martinez, Iliana A.


    This paper reports on the way article writers bring prior texts into biology research articles. It studies the functional moves in which citations occur and their formal features, providing a better understanding of the linguistic resources that are used to construct intertextuality in science. The results show the functions of citations were…



  6. Biology Myth-Killers (United States)

    Lampert, Evan


    "Biology Myth-Killers" is an activity designed to identify and correct common misconceptions for high school and college introductory biology courses. Students identify common myths, which double as biology misconceptions, and use appropriate sources to share the "truth" about the myths. This learner-centered activity is a fun…

  7. 1, 2, 3, 4: infusing quantitative literacy into introductory biology. (United States)

    Speth, Elena Bray; Momsen, Jennifer L; Moyerbrailean, Gregory A; Ebert-May, Diane; Long, Tammy M; Wyse, Sara; Linton, Debra


    Biology of the twenty-first century is an increasingly quantitative science. Undergraduate biology education therefore needs to provide opportunities for students to develop fluency in the tools and language of quantitative disciplines. Quantitative literacy (QL) is important for future scientists as well as for citizens, who need to interpret numeric information and data-based claims regarding nearly every aspect of daily life. To address the need for QL in biology education, we incorporated quantitative concepts throughout a semester-long introductory biology course at a large research university. Early in the course, we assessed the quantitative skills that students bring to the introductory biology classroom and found that students had difficulties in performing simple calculations, representing data graphically, and articulating data-driven arguments. In response to students' learning needs, we infused the course with quantitative concepts aligned with the existing course content and learning objectives. The effectiveness of this approach is demonstrated by significant improvement in the quality of students' graphical representations of biological data. Infusing QL in introductory biology presents challenges. Our study, however, supports the conclusion that it is feasible in the context of an existing course, consistent with the goals of college biology education, and promotes students' development of important quantitative skills.

  8. 1, 2, 3, 4: Infusing Quantitative Literacy into Introductory Biology (United States)

    Momsen, Jennifer L.; Moyerbrailean, Gregory A.; Ebert-May, Diane; Long, Tammy M.; Wyse, Sara; Linton, Debra


    Biology of the twenty-first century is an increasingly quantitative science. Undergraduate biology education therefore needs to provide opportunities for students to develop fluency in the tools and language of quantitative disciplines. Quantitative literacy (QL) is important for future scientists as well as for citizens, who need to interpret numeric information and data-based claims regarding nearly every aspect of daily life. To address the need for QL in biology education, we incorporated quantitative concepts throughout a semester-long introductory biology course at a large research university. Early in the course, we assessed the quantitative skills that students bring to the introductory biology classroom and found that students had difficulties in performing simple calculations, representing data graphically, and articulating data-driven arguments. In response to students' learning needs, we infused the course with quantitative concepts aligned with the existing course content and learning objectives. The effectiveness of this approach is demonstrated by significant improvement in the quality of students' graphical representations of biological data. Infusing QL in introductory biology presents challenges. Our study, however, supports the conclusion that it is feasible in the context of an existing course, consistent with the goals of college biology education, and promotes students' development of important quantitative skills. PMID:20810965

  9. Synthetic biology: putting synthesis into biology. (United States)

    Liang, Jing; Luo, Yunzi; Zhao, Huimin


    The ability to manipulate living organisms is at the heart of a range of emerging technologies that serve to address important and current problems in environment, energy, and health. However, with all its complexity and interconnectivity, biology has for many years been recalcitrant to engineering manipulations. The recent advances in synthesis, analysis, and modeling methods have finally provided the tools necessary to manipulate living systems in meaningful ways and have led to the coining of a field named synthetic biology. The scope of synthetic biology is as complicated as life itself--encompassing many branches of science and across many scales of application. New DNA synthesis and assembly techniques have made routine customization of very large DNA molecules. This in turn has allowed the incorporation of multiple genes and pathways. By coupling these with techniques that allow for the modeling and design of protein functions, scientists have now gained the tools to create completely novel biological machineries. Even the ultimate biological machinery--a self-replicating organism--is being pursued at this moment. The aim of this article is to dissect and organize these various components of synthetic biology into a coherent picture.

  10. The ''Rock'': The Role of the Press in Bringing about Change in Aircraft Accident Policy (United States)

    Johnson, Randy


    From 1926 to 1938, the Aeronautics Branch, forerunner of the Federal Aviation Administration (FAA), had been charged with aircraft accident investigation. While the Branch had been investigating accidents since its inception, it had, early in its tenure, put into place a policy making its findings secret. Media and political pressure began to mount in late 1928 over its policy of nondisclosure and the debate brought pressure to bear on the young Aeronautics Branch to reverse its policy and make its findings public. The focusing event for the Branch's policy reversal was the death of Knute Rockne, the famous Notre Dame football coach, in a Transcontinental and Western Airways (TWA) airliner on March 31, 193 1. This paper will examine the role of print media in bringing about a significant, and lasting, change in aircraft accident public-disclosure policy.

  11. Descendit ad [in] inferna: ‘A matter of no small moment in bringing about redemption’

    Directory of Open Access Journals (Sweden)

    Johan Buitendag


    Full Text Available This article endorses Calvin’s conviction that the ‘descendit ad inferna’ of the Apostles’ Creed is part of the ‘summary of doctrine‘ and a matter of ‘no small moment in bringing about redemption‘ (Calvin 1960:Inst. II, xvi, 8. The reason for this role, however, is not Calvin’s metaphorical interpretation of the clause. Instead, the author tries to argue that a scientific theological approach will maintain the clause because of its transcendence of finitude and the proclamation of Christ’s victory. The whole of creation is delivered from sin. Proper hermeneutics will take the original socio–historical environment into account and make one suspicious about certain ecclesiastical biases. Spatial terms in the Creed should therefore not be demythologised, but rather be transformed in accordance with the insights of the contemporary physics of time and space.

  12. Bringing ideas back in to historical institutionalism to explain endogenous institutional change

    DEFF Research Database (Denmark)

    Carstensen, Martin B.; Schmidt, Vivien

    The problem of how to theorize endogenous institutional change remains the ‘holy grail’ of historical institutionalism. Particularly important advances have been made within scholarship on gradual institutional transformation th at has deployed concepts like institutional ambiguity...... and interpretation to show how actors are able to circumvent and significantly change institutions over the long term or even at crisis moments. Despite the centrality of interpretive processes for this line of argument, historical institutionalists focused on long-term institutional transformation have largely...... shied a way from employing ideas as a central explanatory analytical category. The paper suggests that to endogenize change, historical institutionalists will need to bring ideas back in, and that such engagement with ideational and discursive institutionalist scholarship may be particularly fruitful...

  13. Asperger syndrome and the supposed obligation not to bring disabled lives into the world. (United States)

    Walsh, Pat


    Asperger syndrome (AS) is an autistic spectrum condition that shares the range of social impairments associated with classic autism widely regarded as disabling, while also often giving rise to high levels of ability in areas such as maths, science, engineering and music. The nature of this striking duality of disability and ability is examined, along with its implications for our thinking about disability and the relevance of levels and kinds of disability to reproductive choices. In particular, it may be seen as posing a challenge to John Harris's influential position in reproductive ethics relating to disability. The paper argues that if, as Harris maintains, there is a quite general moral obligation to avoid bringing disabled lives into the world regardless of the level of disability, then AS must be seen as having a strong claim to be exempt from such an obligation. However, a broader critique of Harris's position leads to the conclusion that, in fact, this putative obligation does not exist.

  14. Bringing mini-chalk talks to the bedside to enhance clinical teaching. (United States)

    Pitt, Michael B; Orlander, Jay D


    Chalk talks - where the teacher is equipped solely with a writing utensil and a writing surface - have been used for centuries, yet little has been written about strategies for their use in medical education. Structured education proximal to patient encounters (during rounds, at the bedside, or in between patients in clinic) maximizes the opportunities for clinical learning. This paper presents a strategy to bring mini-chalk talks (MCTs) to the bedside as a practical way to provide relevant clinical teaching by visually framing teachable moments. Grounded in adult learning theory, MCTs leverage teaching scripts to facilitate discussion, involve learners at multiple levels, and embrace the increased retention associated with visual aids. These authors provide specific recommendations for the design and implementation of MCT sessions including what topics work well, how to prepare, and how to involve and engage the learners. ADHD: Attention Deficit Hyperactivity Disorder; MCT: Mini-chalk talks.

  15. The Robobo Project: Bringing Educational Robotics Closer to Real-World Applications

    DEFF Research Database (Denmark)

    Bellas, Francisco; Naya, Martin; Varela, Gervasio


    The Robobo Project is a STEM-based project that aims to bring educational robotics, in primary and high school, closer to real-world applications. It is based on the use of a smartphone-based robotic platform called Robobo, a very flexible programming environment, and a set of lessons to integrate...... them. The smartphone provides high-level hardware capabilities in terms of sensors, communications and processing capabilities that allow to create more practical and realistic lessons that exploit human-robot interaction, with a small investment. In this paper, we present the main elements...... of The Robobo Project in terms of hardware and software, and two illustrative educational projects that can be developed within it....

  16. What Job will Bring Satisfaction? An Analysis based on Responses of Students Studying Business in Kazakhstan

    Directory of Open Access Journals (Sweden)

    Yuliya Frolova


    Full Text Available This research sheds a light on an under-researched topic of job satisfaction in Kazakhstan. Young people, who today are pursuing their bachelor degree, but tomorrow will start working, were chosen as a sample. This article should be especially interesting to employers because it reveals which factors – among those that potentially contribute to job satisfaction – will bring the expected effect in Kazakhstan and thus are worthy of investments. The study is based on the survey conducted by the Society for Human Resource Management (SHRM in the years 2005- 2012 among U.S. employees. The results of the study suggest that rating list of factors that mostly contribute to job satisfaction, which was compiled on the basis of the answers provided by the respondents from Kazakhstan, is quite different from the rating lists of factors mostly contributing to job satisfaction of U.S. employees.

  17. Bringing inorganic chemistry to life with inspiration from R. J. P. Williams. (United States)

    Hill, H Allen O; Sadler, Peter J


    Our appreciation of the scholarly ideas and thinking of Bob Williams is illustrated here by a few of the areas in which he inspired us. His journey to bring inorganic chemistry to life began with an early interest in analytical chemistry, rationalising the relative stabilities of metal coordination complexes (The Irving-Williams Series), and elucidating the organometallic redox chemistry of vitamin B12. He (and Vallee) recognised that metal ions are in energised (entatic) states in proteins and enzymes, which themselves are dynamic structures of rods and springs. He played a key role in helping Rosenberg to pave the road toward the clinic for the anticancer drug cisplatin. He believed that evolution is not just dependent on DNA, but also on the metallome. Organisms and the environment are one system: does DNA code directly for all the essential elements of life?

  18. Bringing the Great American Eclipse of 2017 to Audiences across the Nation (United States)

    Young, C. A.; Mayo, L.; Cline, T. D.; Ng, C.; Stephenson, B. E.


    The August 21, 2017 eclipse across America will be seen by an estimated 500 million people from northern Canada to South America as well as parts of western Europe and Africa. Through This "Great American Eclipse" NASA in partnership with Google, the American Parks Network, American Astronomical Society, the Astronomical League, and numerous other science, education, outreach, and public communications groups and organizations will develop the approaches, resources, partnerships, and technology applications necessary to bring the excitement and the science of the August 21st, 2017 total solar eclipse across America to formal and informal audiences in the US and around the world. This effort will be supported by the highly visible and successful Sun Earth Days program and will be the main theme for Sun-Earth Days 2017.This presentation will discuss NASA's education and communication plans for the eclipse and will detail a number of specific programs and partnerships being leveraged to enhance our reach and impact.

  19. University of Washington Mobile Planetarium: Bringing HST Science to Seattle Public Schools (United States)

    Gailey, Justin; Fraiser, O.; Rosenfield, P.; Byler, E.; Wisniewski, J. P.


    Digital planetariums are becoming mainstays of astronomy education as projection technology prices fall and planetarium software becomes more powerful and more freely available. In 2010, the University of Washington upgraded their star-ball projector to a digital system that is powered by Microsoft Research’s WorldWide Telescope. To increase the number of underserved elementary and high school students the UW Astronomy department reaches, we obtained an HST education and public outreach grant to create lesson content, offset transportation costs to visit the UW planetarium for Seattle Public School students, and purchase a mobile planetarium to bring to public schools. We present a pilot program to test and evaluate the efficacy of the mobile planetarium in a high school setting.

  20. Historical note: How bringing women's health advocacy groups to WHO helped change the research agenda. (United States)

    Cottingham, Jane


    The politics of population control and its sometimes coercive methods in developing countries documented during the 1960s, 70s and 80s, gave rise to strong opposition by women's groups, and put into question the safety of contraceptive methods that were being developed and introduced into countries. In 1991, the Special Programme on Human Reproduction at the World Health Organization, a research programme focused on development of new methods and safety assessments of existing fertility regulation methods, started a process of "dialogue" meetings between scientists and women's health advocacy groups which lasted for nearly a decade. This paper describes the process of these meetings and what they achieved in terms of bringing new or different research topics into the agenda, and some of the actions taken as a result. Copyright © 2015. Published by Elsevier Ltd.

  1. Can programming frameworks bring smartphones into the mainstream of psychological science?

    Directory of Open Access Journals (Sweden)

    Lukasz Piwek


    Full Text Available Smartphones continue to provide huge potential for psychological science and the advent of novel research frameworks brings new opportunities for researchers who have previously struggled to develop smartphone applications. However, despite this renewed promise, smartphones have failed to become a standard item within psychological research. Here we consider the key barriers that continue to limit smartphone adoption within psychological science and how these barriers might be diminishing in light of ResearchKit and other recent methodological developments. We conclude that while these programming frameworks are certainly a step in the right direction it remains challenging to create usable research-orientated applications with current frameworks. Smartphones may only become an asset for psychology and social science as a whole when development software that is both easy to use, secure, and becomes freely available.

  2. Bringing aerospace images into coincidence with subpixel accuracy by the local-correlation method (United States)

    Potapov, A. S.; Malyshev, I. A.; Lutsiv, V. R.


    This paper proposes a local-correlation method that makes it possible to bring aerospace images into coincidence with subpixel accuracy after preliminary rough juxtaposition by transforming them relative to each other by uniform projective transformation and by additional mutual local displacements. The basis of the method is to establish a correspondence between the points of a pair of images by means of a phase correlation of individual segments of the images. The dissemination of information concerning measured shifts from reference points for which the correspondence has been found on a pair of images, as well as the use of analysis with variable spatial resolution, makes the method workable when the errors of the preliminary superposition are greater than the size of the correlation window. This paper presents the results of an experimental verification of the approach, using actual pairs of aerospace images as an example.© 2004

  3. Organisational Capabilities Required for Enabling Employee Mobility through Bring- Your-Own-Device Concept

    Directory of Open Access Journals (Sweden)

    Toperesu B-Abee


    Full Text Available Background: Mobile device adoption is on the rise and people are increasingly using mobile devices as a part of their lives. Studies have shown that people can use mobile devices to perform their work duties from anywhere. Organisations are now exploring ways of enabling and supporting mobility for employees’ mobile devices, including BYOD (Bring-Your-Own-Device policies. Objective: The objective of this study is to identify the main capabilities required for enterprise mobility. Methods/Approach: This qualitative research study presents empirical results based on interviews with selected senior IS managers of large organizations. Results: The main findings of this study suggest that information security and mobile device management are among the main capabilities required for enterprise mobility. Conclusions: Enterprise mobility is an emerging field which has received very little research attention. More research in the field will help organisations make informed decisions on how to increase productivity, sales and efficiency while achieving employee satisfaction through enterprise mobility.

  4. Bringing Online Learning to Campus: The Hybridization of Teaching and Learning at Brigham Young University

    Directory of Open Access Journals (Sweden)

    Gregory L. Waddoups


    Full Text Available The primary purpose of Brigham Young University (BYU is to provide students with a combination of sacred and secular education often described as the "BYU experience". Achieving this purpose is challenged by the rapid growth in Church membership and an enrollment cap of 30,000 students. To address these challenges, BYU sponsors the use of technology to bridge the gap between the increased Church membership and the number of students allowed under the enrollment caps. This institutional case study shows how these challenges have influenced the hybridization of teaching and learning for on campus (resident and off campus (distance students. It also describes how BYU has brought distance education to campus, and is beginning to bring campus-based educational practices to distance education.

  5. Sharing the Stars: Bringing Telescopes to 10-year Olds for International Year of Astronomy (United States)

    Slater, S. J.


    Precisely four hundred years ago, Italian scientist Galileo's observations of the heavens forever and profoundly altered the way we view our place in the Universe. He dramatically increased our thinking about the size of the known Universe by using his telescope and initiated one of the most important scientific revolutions in history. Throughout 2009, children across Wyoming are joining in a United Nations proclaimed International Year of Astronomy celebration. To commemorate 400 years of the telescope in advancing our understanding of the Universe through astronomy, our goal is that every 10-year old child in Wyoming will experience the excitement and wonder of looking through their very own telescope to observe majestic rings surrounding Saturn, deep craters on the Moon, countless stars lining the Milky Way, brilliant phases of Venus, and orbiting moons of Jupiter. This is being accomplished by a massive, state-wide collaborative effort bringing the collective energy and enthusiasm of professional scientists, amateur astronomers, local teachers, and community outreach enthusiasts together to spark an interest in science among Wyoming's children. Our strategy to bring a telescope to every Wyoming 10-year old child started first with a major year-long fundraising campaign. We estimate the cost of an individual telescope, constructed specifically for the 2009 International Year of Astronomy celebration, to be approximately 13 per child. With 6,489 (in 2007) 10- year old children in Wyoming, this amounts to less than 100,000 as a fund raising goal. University of Wyoming faculty are training teachers in how to use telescopes and how to integrate the excitement of astronomy across the curriculum. To teach children how to use their telescopes, volunteers from around the state are hosting star parties at schools, county fairs, and other regularly scheduled community celebrations.

  6. Barrier Free Internet Access: Evaluating the Cyber Security Risk Posed by the Adoption of Bring Your Own Devices to e-Learning Network Infrastructure


    E.T. Tchao; Ansah, Richard Y.; Djane, Seth D.


    The adoption of Bring Your Own Device (BYOD), also known as Bring Your Own Technology (BYOT), Bring Your Own Phone (BYOP), or Bring Your Own Personal Computer (BYOPC), is a policy which allows people access to privileged resources, information and services available on the private computer network of an organization using their own personal computer devices. BYOD, since its emergence in 2009, courtesy of Intel, is now a common practice in many organizations. Academic institutions that attempt...

  7. A critical analysis of the new biology and the biological revolution: their impact - from medicine to evolution. (United States)

    Dev, Sukhendu B


    In this article, I critically analyze the impact of the new biology and the biological revolution. I argue that indiscriminate use of the words such as 'interdisciplinary,' 'integrative,' and 'revolution' has caused only confusion when applied to biology. The recent debate, especially after the exploding field of systems biology, has brought back the controversy whether molecular biology is reductionist or holistic. I look at the issues involved critically. I discuss the problem of defining the word 'gene' and argue that recent attempts to redefine the central dogma of molecular biology about the information flow from DNA to RNA to protein are not justified. I support my view with comments from the scientist who discovered RNA splicing. Several aspects of evo-devo, a new branch of biology, are discussed. I give examples from this evolution-developmental biology to show how some of Darwin's inspired guesses have had resounding victory when it was found that specific genes during embryonic development of the Galapagos finches decided the size and shape of their beaks. I discuss the recent publications which show that the conditions in the island, such as wet to dry to wet season, can bring about evolutionary changes from year to year. Thus it is essential to monitor both short and long-term evolutionary changes to get the full picture of evolution.

  8. Computational systems chemical biology. (United States)

    Oprea, Tudor I; May, Elebeoba E; Leitão, Andrei; Tropsha, Alexander


    There is a critical need for improving the level of chemistry awareness in systems biology. The data and information related to modulation of genes and proteins by small molecules continue to accumulate at the same time as simulation tools in systems biology and whole body physiologically based pharmacokinetics (PBPK) continue to evolve. We called this emerging area at the interface between chemical biology and systems biology systems chemical biology (SCB) (Nat Chem Biol 3: 447-450, 2007).The overarching goal of computational SCB is to develop tools for integrated chemical-biological data acquisition, filtering and processing, by taking into account relevant information related to interactions between proteins and small molecules, possible metabolic transformations of small molecules, as well as associated information related to genes, networks, small molecules, and, where applicable, mutants and variants of those proteins. There is yet an unmet need to develop an integrated in silico pharmacology/systems biology continuum that embeds drug-target-clinical outcome (DTCO) triplets, a capability that is vital to the future of chemical biology, pharmacology, and systems biology. Through the development of the SCB approach, scientists will be able to start addressing, in an integrated simulation environment, questions that make the best use of our ever-growing chemical and biological data repositories at the system-wide level. This chapter reviews some of the major research concepts and describes key components that constitute the emerging area of computational systems chemical biology.

  9. Quantum biological information theory

    CERN Document Server

    Djordjevic, Ivan B


    This book is a self-contained, tutorial-based introduction to quantum information theory and quantum biology. It serves as a single-source reference to the topic for researchers in bioengineering, communications engineering, electrical engineering, applied mathematics, biology, computer science, and physics. The book provides all the essential principles of the quantum biological information theory required to describe the quantum information transfer from DNA to proteins, the sources of genetic noise and genetic errors as well as their effects. Integrates quantum information and quantum biology concepts; Assumes only knowledge of basic concepts of vector algebra at undergraduate level; Provides a thorough introduction to basic concepts of quantum information processing, quantum information theory, and quantum biology; Includes in-depth discussion of the quantum biological channel modelling, quantum biological channel capacity calculation, quantum models of aging, quantum models of evolution, quantum models o...

  10. Semantic Web meets Integrative Biology: a survey. (United States)

    Chen, Huajun; Yu, Tong; Chen, Jake Y


    Integrative Biology (IB) uses experimental or computational quantitative technologies to characterize biological systems at the molecular, cellular, tissue and population levels. IB typically involves the integration of the data, knowledge and capabilities across disciplinary boundaries in order to solve complex problems. We identify a series of bioinformatics problems posed by interdisciplinary integration: (i) data integration that interconnects structured data across related biomedical domains; (ii) ontology integration that brings jargons, terminologies and taxonomies from various disciplines into a unified network of ontologies; (iii) knowledge integration that integrates disparate knowledge elements from multiple sources; (iv) service integration that build applications out of services provided by different vendors. We argue that IB can benefit significantly from the integration solutions enabled by Semantic Web (SW) technologies. The SW enables scientists to share content beyond the boundaries of applications and websites, resulting into a web of data that is meaningful and understandable to any computers. In this review, we provide insight into how SW technologies can be used to build open, standardized and interoperable solutions for interdisciplinary integration on a global basis. We present a rich set of case studies in system biology, integrative neuroscience, bio-pharmaceutics and translational medicine, to highlight the technical features and benefits of SW applications in IB.

  11. How does evolution tune biological noise ?

    Directory of Open Access Journals (Sweden)

    Magali eRichard


    Full Text Available Part of molecular and phenotypic differences between individual cells, between body parts, or between individuals can result from biological noise. This source of variation is becoming more and more apparent thanks to the recent advances in dynamic imaging and single-cell analysis. Some of these studies showed that the link between genotype and phenotype is not strictly deterministic. Mutations can change various statistical properties of a biochemical reaction, and thereby the probability of a trait outcome. The fact that they can modulate phenotypic noise brings up an intriguing question: how may selection act on these mutations? In this review, we approach this question by first covering the evidence that biological noise is under genetic control and therefore a substrate for evolution. We then sequentially inspect the possibilities of negative, neutral and positive selection for mutations increasing biological noise. Finally, we hypothesize on the specific case of H2A.Z, which was shown to both buffer phenotypic noise and modulate transcriptional efficiency.

  12. How does evolution tune biological noise? (United States)

    Richard, Magali; Yvert, Gaël


    Part of molecular and phenotypic differences between individual cells, between body parts, or between individuals can result from biological noise. This source of variation is becoming more and more apparent thanks to the recent advances in dynamic imaging and single-cell analysis. Some of these studies showed that the link between genotype and phenotype is not strictly deterministic. Mutations can change various statistical properties of a biochemical reaction, and thereby the probability of a trait outcome. The fact that they can modulate phenotypic noise brings up an intriguing question: how may selection act on these mutations? In this review, we approach this question by first covering the evidence that biological noise is under genetic control and therefore a substrate for evolution. We then sequentially inspect the possibilities of negative, neutral, and positive selection for mutations increasing biological noise. Finally, we hypothesize on the specific case of H2A.Z, which was shown to both buffer phenotypic noise and modulate transcriptional efficiency.

  13. Darwin's Galapagos finches in modern biology. (United States)

    Abzhanov, Arhat


    One of the classic examples of adaptive radiation under natural selection is the evolution of 15 closely related species of Darwin's finches (Passeriformes), whose primary diversity lies in the size and shape of their beaks. Since Charles Darwin and other members of the Beagle expedition collected these birds on the Galápagos Islands in 1835 and introduced them to science, they have been the subjects of intense research. Many biology textbooks use Darwin's finches to illustrate a variety of topics of evolutionary theory, such as speciation, natural selection and niche partitioning. Today, as this Theme Issue illustrates, Darwin's finches continue to be a very valuable source of biological discovery. Certain advantages of studying this group allow further breakthroughs in our understanding of changes in recent island biodiversity, mechanisms of speciation and hybridization, evolution of cognitive behaviours, principles of beak/jaw biomechanics as well as the underlying developmental genetic mechanisms in generating morphological diversity. Our objective was to bring together some of the key workers in the field of ecology and evolutionary biology who study Darwin's finches or whose studies were inspired by research on Darwin's finches. Insights provided by papers collected in this Theme Issue will be of interest to a wide audience.

  14. Standard biological parts knowledgebase. (United States)

    Galdzicki, Michal; Rodriguez, Cesar; Chandran, Deepak; Sauro, Herbert M; Gennari, John H


    We have created the Knowledgebase of Standard Biological Parts (SBPkb) as a publically accessible Semantic Web resource for synthetic biology ( The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts ( SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL), a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  15. Standard biological parts knowledgebase.

    Directory of Open Access Journals (Sweden)

    Michal Galdzicki


    Full Text Available We have created the Knowledgebase of Standard Biological Parts (SBPkb as a publically accessible Semantic Web resource for synthetic biology ( The SBPkb allows researchers to query and retrieve standard biological parts for research and use in synthetic biology. Its initial version includes all of the information about parts stored in the Registry of Standard Biological Parts ( SBPkb transforms this information so that it is computable, using our semantic framework for synthetic biology parts. This framework, known as SBOL-semantic, was built as part of the Synthetic Biology Open Language (SBOL, a project of the Synthetic Biology Data Exchange Group. SBOL-semantic represents commonly used synthetic biology entities, and its purpose is to improve the distribution and exchange of descriptions of biological parts. In this paper, we describe the data, our methods for transformation to SBPkb, and finally, we demonstrate the value of our knowledgebase with a set of sample queries. We use RDF technology and SPARQL queries to retrieve candidate "promoter" parts that are known to be both negatively and positively regulated. This method provides new web based data access to perform searches for parts that are not currently possible.

  16. Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum. (United States)

    Plowright, Alleyn T; Ottmann, Christian; Arkin, Michelle; Auberson, Yves P; Timmerman, Henk; Waldmann, Herbert


    The scientific advances being made across all disciplines are creating ever-increasing opportunities to enhance our knowledge of biological systems and how they relate to human disease. One of the central driving forces in discovering new medicines is medicinal chemistry, where the design and synthesis of novel compounds has led to multiple drugs. Chemical biology, sitting at the interface of many disciplines, has now emerged as a major contributor to the understanding of biological systems and is becoming an integral part of drug discovery. Bringing chemistry and biology much closer and blurring the boundaries between disciplines is creating new opportunities to probe and understand biology; both disciplines play key roles and need to join forces and work together effectively to synergize their impact. The power of chemical biology will then reach its full potential and drive innovation, leading to the discovery of transformative medicines to treat patients. Advances in cancer biology and drug discovery highlight this potential. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Biological tracer method (United States)

    Strong-Gunderson, Janet M.; Palumbo, Anthony V.


    The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer.

  18. Plant synthetic biology. (United States)

    Liu, Wusheng; Stewart, C Neal


    Plant synthetic biology is an emerging field that combines engineering principles with plant biology toward the design and production of new devices. This emerging field should play an important role in future agriculture for traditional crop improvement, but also in enabling novel bioproduction in plants. In this review we discuss the design cycles of synthetic biology as well as key engineering principles, genetic parts, and computational tools that can be utilized in plant synthetic biology. Some pioneering examples are offered as a demonstration of how synthetic biology can be used to modify plants for specific purposes. These include synthetic sensors, synthetic metabolic pathways, and synthetic genomes. We also speculate about the future of synthetic biology of plants. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Branching processes in biology

    CERN Document Server

    Kimmel, Marek


    This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second ex...

  20. Observing a Client's Grieving Process: Bringing Logical Positivism into Qualitative Grief Counselling Research (United States)

    Wilson, John; Gabriel, Lynne; James, Hazel


    This positional paper originates from our need as researcher/practitioners to establish a meaningful epistemological framework for research into bereaved people's journey through loss and grief over time. We describe how the field of grief research has a long and established biological basis, in keeping with a positivist epistemology.…

  1. Learning Information Patterns in Biological Databases - Stochastic Data Mining (United States)

    Singh, Gautam B.

    This chapter aims at developing the computational theory for modeling patterns and their hierarchical coordination within biological sequences. With the exception of the promoters and enhancers, the functional significance of the non-coding DNA is not well understood. Scientists are now discovering that specific regions of non-coding DNA interact with the cellular machinery and help bring about the expression of genes. Our premise is that it is possible to study the arrangements of patterns in biological sequences through machine learning algorithms. As the biological database continue their exponential growth, it becomes feasible to apply in-silico Data Mining algorithms to discover interesting patterns of motif arrangements and the frequency of their re-iteration. A systematic procedure for achieving this goal is presented.

  2. Biological detector and method (United States)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F


    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  3. SciServer Compute brings Analysis to Big Data in the Cloud (United States)

    Raddick, Jordan; Medvedev, Dmitry; Lemson, Gerard; Souter, Barbara


    SciServer Compute uses Jupyter Notebooks running within server-side Docker containers attached to big data collections to bring advanced analysis to big data "in the cloud." SciServer Compute is a component in the SciServer Big-Data ecosystem under development at JHU, which will provide a stable, reproducible, sharable virtual research environment.SciServer builds on the popular CasJobs and SkyServer systems that made the Sloan Digital Sky Survey (SDSS) archive one of the most-used astronomical instruments. SciServer extends those systems with server-side computational capabilities and very large scratch storage space, and further extends their functions to a range of other scientific disciplines.Although big datasets like SDSS have revolutionized astronomy research, for further analysis, users are still restricted to downloading the selected data sets locally - but increasing data sizes make this local approach impractical. Instead, researchers need online tools that are co-located with data in a virtual research environment, enabling them to bring their analysis to the data.SciServer supports this using the popular Jupyter notebooks, which allow users to write their own Python and R scripts and execute them on the server with the data (extensions to Matlab and other languages are planned). We have written special-purpose libraries that enable querying the databases and other persistent datasets. Intermediate results can be stored in large scratch space (hundreds of TBs) and analyzed directly from within Python or R with state-of-the-art visualization and machine learning libraries. Users can store science-ready results in their permanent allocation on SciDrive, a Dropbox-like system for sharing and publishing files. Communication between the various components of the SciServer system is managed through SciServer‘s new Single Sign-on Portal.We have created a number of demos to illustrate the capabilities of SciServer Compute, including Python and R scripts

  4. Bringing it All Together: NODC's Geoportal Server as an Integration Tool for Interoperable Data Services (United States)

    Casey, K. S.; Li, Y.


    The US National Oceanographic Data Center (NODC) has implemented numerous interoperable data technologies in recent years to enhance the discovery, understanding, and use of the vast quantities of data in the NODC archives. These services include OPeNDAP's Hyrax server, Unidata's THREDDS Data Server (TDS), NOAA's Live Access Server (LAS), and most recently the ESRI ArcGIS Server. Combined, these technologies enable NODC to provide access to its data holdings and products through most of the commonly-used standardized web services like the Data Access Protocol (DAP) and the Open Geospatial Consortium suite of services such as the Web Mapping Service (WMS) and Web Coverage Service (WCS). Despite the strong demand for and use of these services, the acronym-rich environment of services can also result in confusion for producers of data to the NODC archives, for consumers of data from the NODC archives, and for the data stewards at the archives as well. The situation is further complicated by the fact that NODC also maintains some ad hoc services like WODselect, and that not all services can be applied to all of the tens of thousands of collections in the NODC archive; where once every data set was available only through FTP and HTTP servers, now many are also available from the LAS, TDS, Hyrax, and ArcGIS Server. To bring order and clarity to this potentially confusing collection of services, NODC deployed the Geoportal Server into its Archive Management System as an integrating technology that brings together its various data access, visualization, and discovery services as well as its overall metadata management workflows. While providing an enhanced web-based interface for more integrated human-to-machine discovery and access, the deployment also enables NODC for the first time to support a robust set of machine-to-machine discovery services such as the Catalog Service for the Web (CS/W), OpenSearch, and Search and Retrieval via URL (SRU) . This approach allows NODC

  5. Systems Biology of Metabolism. (United States)

    Nielsen, Jens


    Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.

  6. Biological Water Quality Criteria (United States)

    Page contains links to Technical Documents pertaining to Biological Water Quality Criteria, including, technical assistance documents for states, tribes and territories, program overviews, and case studies.

  7. Separating biological cells (United States)

    Brooks, D. E.


    Technique utilizing electric field to promote biological cell separation from suspending medium in zero gravity increases speed, reduces sedimentation, and improves efficiency of separation in normal gravity.

  8. Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position (United States)

    Winter, Evelyn; Gozzi, Gustavo Jabor; Chiaradia-Delatorre, Louise Domeneghini; Daflon-Yunes, Nathalia; Terreux, Raphael; Gauthier, Charlotte; Mascarello, Alessandra; Leal, Paulo César; Cadena, Silvia M; Yunes, Rosendo Augusto; Nunes, Ricardo José; Creczynski-Pasa, Tania Beatriz; Di Pietro, Attilio


    A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors of breast cancer resistance protein-mediated mitoxantrone efflux. These compounds appeared more efficient than analogs containing other B-ring substituents such as 2-naphthyl or 3,4-methylenedioxyphenyl while an intermediate inhibitory activity was obtained with a 1-naphthyl group. In all cases, two or three methoxy groups had to be present on the phenyl A-ring to produce a maximal inhibition. Molecular modeling indicated both electrostatic and steric positive contributions. A higher potency was observed when the 2-naphthyl or 3,4-methylenedioxyphenyl group was shifted to the A-ring and methoxy substituents were shifted to the phenyl B-ring, indicating preferences among polyspecificity of inhibition. PMID:24920885

  9. Process evaluation of bringing nutrition screening to seniors in Canada (BNSS). (United States)

    Keller, Heather H; Haresign, Helen; Brockest, Beverly


    Although nutrition risk is prevalent in Canadian older adults, the process of screening must be considered before nationwide programs can be recommended. A process evaluation of the Bringing Nutrition Screening to Seniors in Canada demonstration project was completed. Through the use of the 15-item Seniors in the Community: Risk Evaluation for Eating and Nutrition (SCREEN(c)) questionnaire, risk was identified in convenience samples of 1,196 community-living older adults recruited from five Canadian communities. All at-risk participants were offered referrals to community resources. Telephone follow-up of at-risk participants occurred after screening. Telephone interviews with screening administrators and older adults revealed screening benefits and challenges. Nutrition risk occurred in 38.9% of the sample. Most participants found screening helpful. Among the at-risk group (n=465), 39% accepted referrals for additional services. Older adults provided several reasons for refusing referrals, including denial of risk. Dietitian services were an identified gap, as were prevention-level resources. Nutrition risk is prevalent and older adults can benefit from screening. Training, ongoing support, and prioritization (policy, time, and money) are needed for sustainable screening programs. Before implementation of a nationwide screening program, sufficient and appropriate community resources are required, as is a national strategy for screening older adults.

  10. Bringing Javanesse Traditional Dance into Basic Physics Class: Exemplifying Projectile Motion through Video Analysis (United States)

    Handayani, Langlang; Prasetya Aji, Mahardika; Susilo; Marwoto, Putut


    An alternative approach of an arts-based instruction for Basic Physics class has been developed through the implementation of video analysis of a Javanesse traditional dance: Bambangan Cakil. A particular movement of the dance -weapon throwing- was analyzed by employing the LoggerPro software package to exemplify projectile motion. The results of analysis indicated that the movement of the thrown weapon in Bambangan Cakil dance provides some helping explanations of several physics concepts of projectile motion: object's path, velocity, and acceleration, in a form of picture, graph and also table. Such kind of weapon path and velocity can be shown via a picture or graph, while such concepts of decreasing velocity in y direction (weapon moving downward and upward) due to acceleration g can be represented through the use of a table. It was concluded that in a Javanesse traditional dance there are many physics concepts which can be explored. The study recommends to bring the traditional dance into a science class which will enable students to get more understanding of both physics concepts and Indonesia cultural heritage.

  11. Bringing the (disabled) body to personality psychology: A case study of Samantha. (United States)

    Adler, Jonathan M


    Personality psychology has largely ignored the experiences of people with disabilities. This article strives to bring the thriving, interdisciplinary field of disability studies to personality psychology via a case study of Samantha (N = 1). Samantha feels that she grew up as a hearing person who could not hear and is now a deaf person who can hear. Narrative identity provides the theoretical, methodological, and analytical framework for the rich, qualitative examination of Samantha's life story, interwoven with approaches from disability studies and intersectionality theory. Two Life Story Interviews (McAdams, 2008), conducted 2 weeks prior to Samantha's cochlear implant surgery and again 7 weeks after the surgery, provide the foundation for this case study and are interpreted alongside additional self-report measures. Grounded theory methods were used to interpret Samantha's narrative identity. Samantha's story demonstrates the ways in which narrative identity can serve as a foundation for meaning and psychological well-being, as well as a demonstration of the ways in which the study of identity can be enriched by perspectives from disability studies. As an initial effort at integrating personality psychology and disability studies, this article sought to approach this task by privileging ethical representation over generalizability. © 2017 Wiley Periodicals, Inc.

  12. Bringing natural behaviors into the laboratory: a tribute to Paul MacLean. (United States)

    Blanchard, Robert J; Blanchard, D Caroline


    Paul MacLean's work has exemplified and encouraged an approach in which natural behaviors are elicited and investigated in laboratory settings. Our own experiences with bringing natural behaviors into the laboratory indicate that this is best achieved by providing the social and environmental stimuli necessary to support these behaviors and by an initial process of ethological/observational analysis of them. Examples discussed in support of these suggestions include the development of more natural habitats, including visible burrow systems (VBS), for fossorial rodents such as rats and mice; analysis of aggressive and defensive behaviors among social groups in such habitats and to introduced predators; and the development of defense test batteries in which individual defensive behaviors may be elicited through manipulations of threat and environmental stimuli. These situations have proved useful in analysis of the effects of drugs active against anxiety-related psychopathologies. However, an equally important use for them is in the analysis of normal defensive and aggressive behaviors. Detailed analysis of natural behaviors in socially and environmentally adequate situations provides an important link between molecular findings and both normal and pathological behavior patterns. Investigation of natural behaviors in adequate stimulus contexts does not represent an antiexperimental stance but one that supplements and enhances the generalizability of more conventional experimental laboratory approaches.

  13. The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions (United States)

    Ferrao, Ryan; Lupardus, Patrick J.


    The Janus kinases (JAKs) are non-receptor tyrosine kinases essential for signaling in response to cytokines and interferons and thereby control many essential functions in growth, development, and immune regulation. JAKs are unique among tyrosine kinases for their constitutive yet non-covalent association with class I and II cytokine receptors, which upon cytokine binding bring together two JAKs to create an active signaling complex. JAK association with cytokine receptors is facilitated by N-terminal FERM and SH2 domains, both of which are classical mediators of peptide interactions. Together, the JAK FERM and SH2 domains mediate a bipartite interaction with two distinct receptor peptide motifs, the proline-rich “Box1” and hydrophobic “Box2,” which are present in the intracellular domain of cytokine receptors. While the general sidechain chemistry of Box1 and Box2 peptides is conserved between receptors, they share very weak primary sequence homology, making it impossible to posit why certain JAKs preferentially interact with and signal through specific subsets of cytokine receptors. Here, we review the structure and function of the JAK FERM and SH2 domains in light of several recent studies that reveal their atomic structure and elucidate interaction mechanisms with both the Box1 and Box2 receptor motifs. These crystal structures demonstrate how evolution has repurposed the JAK FERM and SH2 domains into a receptor-binding module that facilitates interactions with multiple receptors possessing diverse primary sequences. PMID:28458652

  14. The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions. (United States)

    Ferrao, Ryan; Lupardus, Patrick J


    The Janus kinases (JAKs) are non-receptor tyrosine kinases essential for signaling in response to cytokines and interferons and thereby control many essential functions in growth, development, and immune regulation. JAKs are unique among tyrosine kinases for their constitutive yet non-covalent association with class I and II cytokine receptors, which upon cytokine binding bring together two JAKs to create an active signaling complex. JAK association with cytokine receptors is facilitated by N-terminal FERM and SH2 domains, both of which are classical mediators of peptide interactions. Together, the JAK FERM and SH2 domains mediate a bipartite interaction with two distinct receptor peptide motifs, the proline-rich "Box1" and hydrophobic "Box2," which are present in the intracellular domain of cytokine receptors. While the general sidechain chemistry of Box1 and Box2 peptides is conserved between receptors, they share very weak primary sequence homology, making it impossible to posit why certain JAKs preferentially interact with and signal through specific subsets of cytokine receptors. Here, we review the structure and function of the JAK FERM and SH2 domains in light of several recent studies that reveal their atomic structure and elucidate interaction mechanisms with both the Box1 and Box2 receptor motifs. These crystal structures demonstrate how evolution has repurposed the JAK FERM and SH2 domains into a receptor-binding module that facilitates interactions with multiple receptors possessing diverse primary sequences.

  15. Bringing electronic patient records into health professional education: towards an integrative framework. (United States)

    Kushniruk, Andre W; Borycki, Elizabeth M; Armstrong, Brian; Joe, Ron; Otto, Tony


    In this paper we discuss our approach for integrating electronic patient records into health professional education. Electronic patient record (EPR) use is increasing globally. The EPR is considered the cornerstone of the modernization and streamlining of healthcare worldwide. However, despite the importance of the EPR, health professional education in much of the world provides health professional students (who will become the practicing health professionals of the future) with limited access or knowledge about the EPR. New ways of exposing students to EPRs will be needed in order to ensure that health professionals will adopt and use this complex technology wisely and effect the positive benefits EPRs are expected to bring to healthcare globally. In this paper we describe: (a) a framework we have developed for integrating EPRs into health professional education and (b) an innovative Web portal, known as the University of Victoria Electronic Health Record (EHR) Educational Portal (which houses a number of EPRs) that can be used to explore the integration of EPRs in health professional education. It is hoped that adoption and use of EPRs will ultimately be improved through the use of the portal to allow students virtual and ubiquitous access to example EPRs, coupled with principled educational approaches for integrating EPR technology into health professional curricula.

  16. Bringing People Back into Protected Forests in Developing Countries: Insights from Co-Management in Malawi

    Directory of Open Access Journals (Sweden)

    Leo Zulu


    Full Text Available This study examines struggles to bring people back into protected forests to enhance sustainable forest management and livelihoods using insights emerging from a co-management project in Malawi. It uses mixed social science methods and a process-based conceptualization of co-management to analyze experiences, and theory of reciprocal altruism to explain major findings of continuing local forest-user commitment to co-management despite six years of conservation burdens largely for minimal financial benefits. It argues that overemphasis on cash incentives as the motivation for “self-interested” users to participate in co-management overlooks locally significant non-cash motivations, inflates local expectations, and creates perverse incentives that undermine socio-ecological goals. Some non-cash incentives outweighed cash-driven ones. Findings support broadening of incentives mechanisms, including via nested cross-scale institutional arrangements for holistic management that integrates adjacent forests into forest-reserve co-management. Strengthened institutions, improving community/government and intra-community trust, improved village forests easing pressure on the reserve, measures minimizing elite capture, and impetus from an external threat, enhanced forest condition. Generous forest rights and appropriate community licensing and benefit-sharing systems also helped. Bureaucratic/donor inefficiencies, wood-extraction challenges, poor forest-based enterprise development, and low resource value undermined performance. Insights on forest-management planning, fair cost-sharing, targeting the poor, and need for social learning are highlighted.

  17. SOP 98-5 brings uniformity to reporting start-up costs. (United States)

    Luecke, R W; Meeting, D T


    The American Institute of Certified Public Accountants (AICPA) issued Statement of Position (SOP) No. 98-5, Reporting on the Costs of Start-Up Activities, in April 1998 to provide organizations with guidance on how to report start-up and organization costs. Because some companies were expensing start-up costs while other companies were capitalizing start-up costs with a variety of periods over which to amortize costs, it was difficult to compare companies' financial statements. SOP No. 98-5 will bring uniformity to the treatment of start-up and organization costs by dictating that these costs be expensed as incurred. AICPA's Accounting Standards Executive Committee adopted an intentionally broad definition of start-up costs to capture the vast majority of costs associated with starting up an organization. SOP No. 98-5 takes effect for financial statements for fiscal years beginning after December 15, 1998, but can be applied earlier for fiscal years for which financial statements have not been issued.

  18. Issues and Solutions for Bringing Heterogeneous Water Cycle Data Sets Together (United States)

    Acker, James; Kempler, Steven; Teng, William; Belvedere, Deborah; Liu, Zhong; Leptoukh, Gregory


    The water cycle research community has generated many regional to global scale products using data from individual NASA missions or sensors (e.g., TRMM, AMSR-E); multiple ground- and space-based data sources (e.g., Global Precipitation Climatology Project [GPCP] products); and sophisticated data assimilation systems (e.g., Land Data Assimilation Systems [LDAS]). However, it is often difficult to access, explore, merge, analyze, and inter-compare these data in a coherent manner due to issues of data resolution, format, and structure. These difficulties were substantiated at the recent Collaborative Energy and Water Cycle Information Services (CEWIS) Workshop, where members of the NASA Energy and Water cycle Study (NEWS) community gave presentations, provided feedback, and developed scenarios which illustrated the difficulties and techniques for bringing together heterogeneous datasets. This presentation reports on the findings of the workshop, thus defining the problems and challenges of multi-dataset research. In addition, the CEWIS prototype shown at the workshop will be presented to illustrate new technologies that can mitigate data access roadblocks encountered in multi-dataset research, including: (1) Quick and easy search and access of selected NEWS data sets. (2) Multi-parameter data subsetting, manipulation, analysis, and display tools. (3) Access to input and derived water cycle data (data lineage). It is hoped that this presentation will encourage community discussion and feedback on heterogeneous data analysis scenarios, issues, and remedies.

  19. The QuarkNet CMS masterclass: bringing the LHC to students (United States)

    Cecire, Kenneth; McCauley, Thomas


    QuarkNet is an educational program which brings high school teachers and their students into the particle physics research community. The program supports research experiences and professional development workshops and provides inquiry-oriented investigations, some using real experimental data. The CMS experiment at the LHC has released several thousand proton-proton collision events for use in education and outreach. QuarkNet, in collaboration with CMS, has developed a physics masterclass and e-Lab based on this data. A masterclass is a day-long educational workshop where high school students travel to nearby universities and research laboratories. There they learn from LHC physicists about the basics of particle physics and detectors. They then perform a simple measurement using LHC data, and share their results with other students around the world via videoconference. Since 2011 thousands of students from over 25 countries have participated in the CMS masterclass as organized by QuarkNet and the International Particle Physics Outreach Group (IPPOG).We describe here the masterclass exercise: the physics, the online event display and database preparation behind it, the measurement the students undertake, their results and experiences, and future plans for the exercise.

  20. EXPLORE: An action to bring science and technology closer to secondary school

    Directory of Open Access Journals (Sweden)

    Nuria Torras-Melenchon


    Full Text Available This paper presents the experience of an initiative, the EXPLORE courses, designed to bring science and technology closer to secondary school and to encourage scientific and technological vocations. The EXPLORE courses, organised by “EXPLORATORI dels Recursos de la Natura” project, are particularly addressed to secondary school teachers and are conducted at Catalonia (north-east of Spain. The main objective is to provide secondary school teachers with the opportunity to explore the natural resources. Based on a combination of face-to-face and online learning, the programme of the courses uses an interdisciplinary approach, integrating science, technology, engineering, and mathematics (STEM and STEAM (STEM + art fields. Data presented in this paper correspond to the 2012 and 2013 editions. The results, which were obtained from a written questionnaire completed by participating teachers of EXPLORE courses, indicate that more than 70% of secondary school teachers were encouraged to introduce some course contents on their teaching classes after participating in an EXPLORE course.

  1. Bringing home the health humanities: narrative humility, structural competency, and engaged pedagogy. (United States)

    Tsevat, Rebecca K; Sinha, Anoushka A; Gutierrez, Kevin J; DasGupta, Sayantani


    As health humanities programs grow and thrive across the country, encouraging medical students to read, write, and become more reflective about their professional roles, educators must bring a sense of self-reflexivity to the discipline itself. In the health humanities, novels, patient histories, and pieces of reflective writing are often treated as architectural spaces or "homes" that one can enter and examine. Yet, narrative-based learning in health care settings does not always allow its participants to feel "at home"; when not taught with a critical attention to power and pedagogy, the health humanities can be unsettling and even dangerous. Educators can mitigate these risks by considering not only what they teach but also how they teach it.In this essay, the authors present three pedagogical pillars that educators can use to invite learners to engage more fully, develop critical awareness of medical narratives, and feel "at home" in the health humanities. These pedagogical pillars are narrative humility (an awareness of one's prejudices, expectations, and frames of listening), structural competency (attention to sources of power and privilege), and engaged pedagogy (the protection of students' security and well-being). Incorporating these concepts into pedagogical practices can create safe and productive classroom spaces for all, including those most vulnerable and at risk of being "unhomed" by conventional hierarchies and oppressive social structures. This model then can be translated through a parallel process from classroom to clinic, such that empowered, engaged, and cared-for learners become empowering, engaging, and caring clinicians.

  2. The Mauna Kea Observatories Outreach Committee Brings Astronomy To The Hawaiian Public (United States)

    Heyer, I.; Harvey, J.; Usuda, K. S.; Fujihara, G.; Hamilton, J.


    The Mauna Kea Observatories Outreach Committee (MKOOC) combines the outreach activities of the 13 telescopes on Mauna Kea on the Big Island of Hawaii. For the International Year of Astronomy (IYA) 2009 we branded our annual local events, and in addition developed several unique activities and products to bring astronomy to the public during IYA. Our Journey Through The Universe classroom visit and teacher training program was augmented by several evening public events for the whole family. For AstroDay we developed a set of astronomy trading cards, such that people had to visit all the observatory booths to collect the whole set. In collaboration with the local newspapers, we produced an astronomy supplement, available both on paper and online, highlighting the work being done at our observatories. A year-long introductory astronomy class for K-12 teachers was held, emphasizing hands-on activities to teach important concepts. In collaboration with a local supermarket, we held a poster contest for students, making the connection between astronomy and Hawaiian culture. We also participated in the "100 Hours of Astronomy" webcast. In the fall, we celebrated the Galilean Nights with an all-observatories block party, with activities, music, and give-aways.

  3. Bringing Back the Social Affordances of the Paper Memo to Aerospace Systems Engineering Work (United States)

    Davidoff, Scott; Holloway, Alexandra


    Model-based systems engineering (MBSE) is a relatively new field that brings together the interdisciplinary study of technological components of a project (systems engineering) with a model-based ontology to express the hierarchical and behavioral relationships between the components (computational modeling). Despite the compelling promises of the benefits of MBSE, such as improved communication and productivity due to an underlying language and data model, we observed hesitation to its adoption at the NASA Jet Propulsion Laboratory. To investigate, we conducted a six-month ethnographic field investigation and needs validation with 19 systems engineers. This paper contributes our observations of a generational shift in one of JPL's core technologies. We report on a cultural misunderstanding between communities of practice that bolsters the existing technology drag. Given the high cost of failure, we springboard our observations into a design hypothesis - an intervention that blends the social affordances of the narrative-based work flow with the rich technological advantages of explicit data references and relationships of the model-based approach. We provide a design rationale, and the results of our evaluation.

  4. ICT Integrity: bringing the ACS code of ethics up to date

    Directory of Open Access Journals (Sweden)

    Michael Bowern


    Full Text Available Over the last 20 years the ICT industry has seen many developments and changes, such as faster and smaller computers, many new digital devices, the convergence of this digital technology, the internet, and operational aspects such as outsourcing. Governments and professional societies have discussed the issues related to these changes in the media, yet the Australian Computer Society’s Code of Ethics has not changed. This paper discusses the need to change the ACS Code, the issues to be addressed, and procedures to be followed, if changes are to be made. These issues include, amongst others, the lack of specificity of the Code, and the absence of a way to decide between ethical principles which may conflict in some situations, and how to resolve such conflicts. With the focus on the Australian context, the ACS Code’s relationship with international standards and codification of ethics are considered, and the paper discusses what lessons can be learned from overseas experience in modifying codes. The paper concludes by outlining the next steps to bring the ACS Code up to date.

  5. Knowledge base and functionality of concepts of some Filipino biology teachers in five biology topics (United States)

    Barquilla, Manuel B.


    This mixed research, is a snapshot of some Filipino Biology teachers' knowledge structure and how their concepts of the five topics in Biology (Photosynthesis, Cellular Respiration, human reproductive system, Mendelian genetics and NonMendelian genetics) functions and develops inside a biology classroom. The study focuses on the six biology teachers and a total of 222 students in their respective classes. Of the Six (6) teachers, three (3) are under the Science curriculum and the other three (3) are under regular curriculum in both public and private schools in Iligan city and Lanao del Norte, Philippines. The study utilized classroom discourses, concept maps, interpretative case-study method, bracketing method, and concept analysis for qualitative part; the quantitative part uses a nonparametric statistical tool, Kendall's tau Coefficient for determining relationship and congruency while measures of central tendencies and dispersion (mean, and standard deviation) for concept maps scores interpretation. Knowledge Base of Biology teachers were evaluated by experts in field of specialization having a doctorate program (e.g. PhD in Genetics) and PhD Biology candidates. The data collection entailed seven (7) months immersion: one (1) month for preliminary phase for the researcher to gain teachers' and students' confidence and the succeeding six (6) months for main observation and data collection. The evaluation of teachers' knowledge base by experts indicated that teachers' knowledge of (65%) is lower than the minimum (75%) recommended by ABD-el-Khalick and Boujaoude (1997). Thus, the experts believe that content knowledge of the teachers is hardly adequate for their teaching assignment. Moreover, the teachers in this study do not systematically use reallife situation to apply the concepts they teach. They can identify concepts too abstract for their student; however, they seldom use innovative ways to bring the discussion to their students' level of readiness and

  6. Modelling, abstraction, and computation in systems biology: A view from computer science. (United States)

    Melham, Tom


    Systems biology is centrally engaged with computational modelling across multiple scales and at many levels of abstraction. Formal modelling, precise and formalised abstraction relationships, and computation also lie at the heart of computer science--and over the past decade a growing number of computer scientists have been bringing their discipline's core intellectual and computational tools to bear on biology in fascinating new ways. This paper explores some of the apparent points of contact between the two fields, in the context of a multi-disciplinary discussion on conceptual foundations of systems biology. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Borodina, Irina; Li, Mingji


    Synthetic biology and metabolic engineering enable generation of novel cell factories that efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating the basis for biosustainable economy independent on fossil resources. While over a hundred proof-of-concept ch...... computational tools for the prediction of biochemical pathways, molecular biology methods for assembly of DNA parts into pathways, and for introducing the pathways into the host, and finally approaches for optimizing performance of the introduced pathways.......Synthetic biology and metabolic engineering enable generation of novel cell factories that efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating the basis for biosustainable economy independent on fossil resources. While over a hundred proof...... biology has the potential to bring down this cost by improving our ability to predictably engineer biological systems. This review highlights synthetic biology applications for design, assembly, and optimization of non-native biochemical pathways in baker's yeast Saccharomyces cerevisiae. We describe...

  8. Experimenting with Mathematical Biology (United States)

    Sanft, Rebecca; Walter, Anne


    St. Olaf College recently added a Mathematical Biology concentration to its curriculum. The core course, Mathematics of Biology, was redesigned to include a wet laboratory. The lab classes required students to collect data and implement the essential modeling techniques of formulation, implementation, validation, and analysis. The four labs…

  9. Evolutionary Biology Today

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 11. Evolutionary Biology Today - The Domain of Evolutionary Biology. Amitabh Joshi. Series Article Volume 7 Issue 11 November 2002 pp 8-17. Fulltext. Click here to view fulltext PDF. Permanent link:

  10. Biological Clocks & Circadian Rhythms (United States)

    Robertson, Laura; Jones, M. Gail


    The study of biological clocks and circadian rhythms is an excellent way to address the inquiry strand in the National Science Education Standards (NSES) (NRC 1996). Students can study these everyday phenomena by designing experiments, gathering and analyzing data, and generating new experiments. As students explore biological clocks and circadian…


    African Journals Online (AJOL)

    Preferred Customer

    KEY WORDS: Aroylhydrazones, Metal complexes, Biological activity, TGA, Electrical conductivity. INTRODUCTION. Hydrazones constitute an important class of compounds with a wide spectrum of pharmacological properties. They are known to possess a wide range of biological applications. The acid hydrazides have ...

  12. Biologics and biosimilars. (United States)

    Patel, Palak K; King, Caleb R; Feldman, Steven R


    Biological drugs are large, complex glycoprotein molecules produced in living organisms. Revolutionary treatments for many conditions, biologics used in dermatology will face patent expiration, opening opportunities for competitive versions. Biologic drugs are so complex such that it is impossible to reproduce them exactly. Biosimilars are designed to be highly similar, though not identical, to the innovator product. Because biosimilars are not exact replicates of innovator biologics, guidelines have suggested that biosimilars should be considered as unique therapeutic interventions, requiring unique names and physician notification prior to substitution. However, because biologics can never be replicated exactly, even innovator biologics have inherent batch-to-batch variability; when the second batch of innovator products were released, physicians began prescribing non-identical variants of biologics to their patients, accepting the possibility of variation in clinical effects. Unlike the variants in innovator products, biosimilars will provide clinical trial data demonstrating similar clinical effects, though there will always be some degree of uncertainty in how much clinical impact will be result from the variation in both innovator and biosimilar products. How biosimilars are approved and how we use biosimilars will need to balance considerations of cost and development time with the possibility of variation in biological response.

  13. Tropical Freshwater Biology

    African Journals Online (AJOL)

    Tropical Freshwater Biology promotes the publication of scientific contributions in the field of freshwater biology in the tropical and subtropical regions of the world. One issue is published annually but this number may be increased. Original research papers and short communications on any aspect of tropical freshwater ...

  14. Biological dose estimation

    African Journals Online (AJOL)

    to this effect was found in at least 3 cases using biological dosimetric criteria, proving the ... The classification system described by Savage3 was used to determine the ... TABLE I. DISTANCE FROM RADIATION SOURCE, DETAILS OF CYTOGENETIC ANALYSIS AND BIOLOGICAL AND PHYSICAL. DOSE ESTIMATIONS.

  15. Bringing the next Generation of Immuno-Oncology Biomarkers to the Clinic. (United States)

    Cesano, Alessandra; Warren, Sarah


    The recent successes in the use of immunotherapy to treat cancer have led to a multiplicity of new compounds in development. Novel clinical-grade biomarkers are needed to guide the choice of these agents to obtain the maximal likelihood of patient benefit. Predictive biomarkers for immunotherapy differ from the traditional biomarkers used for targeted therapies: the complexity of the immune response and tumour biology requires a more holistic approach than the use of a single analyte biomarker. This paper reviews novel biomarker approaches for the effective development of immune-oncology therapies, highlighting the promise of the advances in next-generation gene expression profiling that allow biologic information to be efficiently organized and interpreted for a maximum predictive value at the individual patient level.

  16. Bringing the next Generation of Immuno-Oncology Biomarkers to the Clinic

    Directory of Open Access Journals (Sweden)

    Alessandra Cesano


    Full Text Available The recent successes in the use of immunotherapy to treat cancer have led to a multiplicity of new compounds in development. Novel clinical-grade biomarkers are needed to guide the choice of these agents to obtain the maximal likelihood of patient benefit. Predictive biomarkers for immunotherapy differ from the traditional biomarkers used for targeted therapies: the complexity of the immune response and tumour biology requires a more holistic approach than the use of a single analyte biomarker. This paper reviews novel biomarker approaches for the effective development of immune-oncology therapies, highlighting the promise of the advances in next-generation gene expression profiling that allow biologic information to be efficiently organized and interpreted for a maximum predictive value at the individual patient level.

  17. Queering animal sexual behavior in biology textbooks

    Directory of Open Access Journals (Sweden)

    Malin Ah-King


    Full Text Available Biology is instrumental in establishing and perpetuating societal norms of gender and sexuality, owing to its afforded authoritative role in formulating beliefs about what is "natural". However, philosophers, historians, and sociologists of science have shown how conceptions of gender and sexuality pervade the supposedly objective knowledge produced by the natural sciences. For example, in describing animal relationships, biologists sometimes use the metaphor of marriage, which brings with it conceptions of both cuckoldry and male ownership of female partners. These conceptions have often led researchers to overlook female behavior and adaptations, such as female initiation of mating. Such social norms and ideologies influence both theories and research in biology. Social norms of gender and sexuality also influence school cultures. Although awareness of gender issues has had a major impact in Sweden during recent years, the interventions conducted have been based on a heteronormative understanding of sex; this has rendered sexual norms a non-prioritized issue and thereby rendered non-heterosexuals invisible in teaching and textbooks. Since this research was published in 2007 and 2009, norm critical pedagogics have been included in the Swedish National Agency for Education's guidelines for teaching. This inclusion represents one way to tackle the recurring problem of heterosexuality being described as a naturalized "normal" behavior and homosexuals, bisexuals and transsexuals being described from a heteronormative perspective. In this paper, I employ gender and queer perspectives to scrutinize how animal sexual behavior is described and explained in Swedish biology textbooks. The analysis is based in gender and queer theory, feminist science studies, and evolutionary biology. The article begins with an outline a discussion of my theoretical framework, relating gender and queer perspectives on evolutionary biology to a discussion of queer

  18. Biological sample collector (United States)

    Murphy, Gloria A [French Camp, CA


    A biological sample collector is adapted to a collect several biological samples in a plurality of filter wells. A biological sample collector may comprise a manifold plate for mounting a filter plate thereon, the filter plate having a plurality of filter wells therein; a hollow slider for engaging and positioning a tube that slides therethrough; and a slide case within which the hollow slider travels to allow the tube to be aligned with a selected filter well of the plurality of filter wells, wherein when the tube is aligned with the selected filter well, the tube is pushed through the hollow slider and into the selected filter well to sealingly engage the selected filter well and to allow the tube to deposit a biological sample onto a filter in the bottom of the selected filter well. The biological sample collector may be portable.

  19. Mechanical Biological Treatment

    DEFF Research Database (Denmark)

    Bilitewski, B-; Oros, Christiane; Christensen, Thomas Højlund


    The basic processes and technologies of composting and anaerobic digestion, as described in the previous chapters, are usually used for specific or source-separated organic waste flows. However, in the 1990s mechanical biological waste treatment technologies (MBT) were developed for unsorted...... technologies (screens, sieves, magnets, etc.) with biological technologies (composting, anaerobic digestion). Two main technologies are available: Mechanical biological pretreatment (MBP), which first removes an RDF fraction and then biologically treats the remaining waste before most of it is landfilled......, and mechanical biological stabilization (MBS), which first composts the waste for drying prior to extraction of a large RDF fraction. Only a small fraction is landfilled. The latter technology is also referred to as biodrying. Within each of the two main technologies, a range of variations is available depending...

  20. Frontiers in mathematical biology

    CERN Document Server


    Volume 100, which is the final volume of the LNBM series serves to commemorate the acievements in two decades of this influential collection of books in mathematical biology. The contributions, by the leading mathematical biologists, survey the state of the art in the subject, and offer speculative, philosophical and critical analyses of the key issues confronting the field. The papers address fundamental issues in cell and molecular biology, organismal biology, evolutionary biology, population ecology, community and ecosystem ecology, and applied biology, plus the explicit and implicit mathematical challenges. Cross-cuttting issues involve the problem of variation among units in nonlinear systems, and the related problems of the interactions among phenomena across scales of space, time and organizational complexity.

  1. Space biology research development (United States)

    Bonting, Sjoerd L.


    The purpose of the Search for Extraterrestrial Intelligence (SETI) Institute is to conduct and promote research related activities regarding the search for extraterrestrial life, particularly intelligent life. Such research encompasses the broad discipline of 'Life in the Universe', including all scientific and technological aspects of astronomy and the planetary sciences, chemical evolution, the origin of life, biological evolution, and cultural evolution. The primary purpose was to provide funding for the Principal Investigator to collaborate with the personnel of the SETI Institute and the NASA-Ames Research center in order to plan and develop space biology research on and in connection with Space Station Freedom; to promote cooperation with the international partners in the space station; to conduct a study on the use of biosensors in space biology research and life support system operation; and to promote space biology research through the initiation of an annual publication 'Advances in Space Biology and Medicine'.

  2. Thirty years of Biology & Philosophy: philosophy of which biology?


    Pradeu, Thomas


    International audience; Which domains of biology do philosophers of biology primarily study? The fact that philosophy of biology has been dominated by an interest for evolutionary biology is widely admitted, but it has not been strictly demonstrated. Here I analyse the topics of all the papers published in Biology & Philosophy, just as the journal celebrates its thirtieth anniversary. I then compare the distribution of biological topics in Biology & Philosophy with that of the scientific jour...

  3. [Concept of mesenchymal stem cells: bring more insights into functional research of MSC]. (United States)

    Zhao, Chun-Hua


    Mesenchymal stem cells have generated great interest among researchers and physicians due to their unique biological characteristics and potential clinical applications. Here, I propose for the first time the concept of a hierarchical system which is composed of all mesenchymal stem cells from post-embryonic subtotipotent stem cells to MSC progenitors. Post-embryonic subtotipotent stem cells are left-over cells during embryonic development and are on the top of the hierarchy. MSC system is a combination of cells that are derived from different stages of embryonic development, possess different differentiation potential and ultimately give rise to cells that share a similar set of phenotypic markers. The concept of MSC system has important implications: (1) it entirely explains the three important biological characteristics of MSC: stem cell properties of MSC, MSC as components of tissue microenvironment and immunomodulatory functions of MSC. (2) It balances immune responses and tissue metabolism. (3) It could provide tissue-specific stem cells for clinical application with high efficiency and safety. In a word, this concept constitutes an important part of the biological properties of MSC and will help researchers gain better insight into MSC.

  4. Mammalian Synthetic Biology: Engineering Biological Systems. (United States)

    Black, Joshua B; Perez-Pinera, Pablo; Gersbach, Charles A


    The programming of new functions into mammalian cells has tremendous application in research and medicine. Continued improvements in the capacity to sequence and synthesize DNA have rapidly increased our understanding of mechanisms of gene function and regulation on a genome-wide scale and have expanded the set of genetic components available for programming cell biology. The invention of new research tools, including targetable DNA-binding systems such as CRISPR/Cas9 and sensor-actuator devices that can recognize and respond to diverse chemical, mechanical, and optical inputs, has enabled precise control of complex cellular behaviors at unprecedented spatial and temporal resolution. These tools have been critical for the expansion of synthetic biology techniques from prokaryotic and lower eukaryotic hosts to mammalian systems. Recent progress in the development of genome and epigenome editing tools and in the engineering of designer cells with programmable genetic circuits is expanding approaches to prevent, diagnose, and treat disease and to establish personalized theranostic strategies for next-generation medicines. This review summarizes the development of these enabling technologies and their application to transforming mammalian synthetic biology into a distinct field in research and medicine.

  5. Value added medicines: what value repurposed medicines might bring to society? (United States)

    Toumi, Mondher; Rémuzat, Cécile


    ABSTRACT Background & objectives: Despite the wide interest surrounding drug repurposing, no common terminology has been yet agreed for these products and their full potential value is not always recognised and rewarded, creating a disincentive for further development. The objectives of the present study were to assess from a wide perspective which value drug repurposing might bring to society, but also to identify key obstacles for adoption of these medicines and to discuss policy recommendations. Methods: A preliminary comprehensive search was conducted to assess how the concept of drug repurposing was described in the literature. Following completion of the literature review, a primary research was conducted to get perspective of various stakeholders across EU member states on drug repurposing (healthcare professionals, regulatory authorities and Health Technology Assessment (HTA) bodies/payers, patients, and representatives of the pharmaceutical industry developing medicines in this field). Ad hoc literature review was performed to illustrate, when appropriate, statements of the various stakeholders. Results: Various nomenclatures have been used to describe the concept of drug repurposing in the literature, with more or less broad definitions either based on outcomes, processes, or being a mix of both. In this context, Medicines for Europe ( established one single terminology for these medicines, known as value added medicines, defined as ‘medicines based on known molecules that address healthcare needs and deliver relevant improvements for patients, healthcare professionals and/or payers’. Stakeholder interviews highlighted three main potential benefits for value added medicines: (1) to address a number of medicine-related healthcare inefficiencies related to irrational use of medicines, non-availability of appropriate treatment options, shortage of mature products, geographical inequity in medicine

  6. Taking the conservation biology perspective to secondary school classrooms. (United States)

    Wyner, Yael; Desalle, Rob


    The influence of conservation biology can be enhanced greatly if it reaches beyond undergraduate biology to students at the middle and high school levels. If a conservation perspective were taught in secondary schools, students who are not interested in biology could be influenced to pursue careers or live lifestyles that would reduce the negative impact of humans on the world. We use what we call the ecology-disrupted approach to transform the topics of conservation biology research into environmental-issue and ecology topics, the major themes of secondary school courses in environmental science. In this model, students learn about the importance and complexity of normal ecological processes by studying what goes wrong when people disrupt them (environmental issues). Many studies published in Conservation Biology are related in some way to the ecological principles being taught in secondary schools. Describing research in conservation biology in the language of ecology curricula in secondary schools can help bring these science stories to the classroom and give them a context in which they can be understood by students. Without this context in the curriculum, a science story can devolve into just another environmental issue that has no immediate effect on the daily lives of students. Nevertheless, if the research is placed in the context of larger ecological processes that are being taught, students can gain a better understanding of ecology and a better understanding of their effect on the world.

  7. A German Geophysics School Project First steps to bring geophysical topics to schoolclasses (United States)

    Schneider, S.


    In Germany Geophysics is a science with almost none or a bad reputation. People do not know to distinguish between Geophysics, Geography and Geology. In order to change the public view on Geosciences, a,School Project Geophysics' is going to be created at the Institute of Meteorology and Geophysics, Johann Wolfgang Goethe University, Frankfurt, which will offer geophysical ideas, methodes and scientific results to schoolclasses. After researches like PISA or TIMSS (third international Math and Nature-Science test) new concepts in education will be required. Interdisciplinary tasks are demanded by national and international commissions.\\The,School Project Geophysics' will be created to bring geophysical themes and results of scientific research into schools. One Day- or one Week-Workshops will help to publish geophysical contents in close cooperation with Physics - and Geography - teachers.\\Hands-on experiments (for advanced pupils) like refraction-Seismics or Magnetic measurements will lead students closer to scientific work and will help to establish personal interests in Earthsciences. Working with personally produced datasets will show the basics of inversion theory and point out the difficulties in creating models. Boundaries of data interpretation (the plurality of variables needed) will teach the school children to see scientific and statistic predictions and declarations more criticaly. Animations and Videos will present global examples (for example of volcanoes or Earthquakes) and lead over to regional sites. Excursions to these sites will help to show fieldwork methods and its problems and will convince to take a different look on topography and landscapes.\\All necessary utilities (Animations, Videos, Pictures and foils) will be offered to teachers in an online-data base which will be installed and managed by the project. Teachers and pupils might get easily into contact with Scientists to discuss geoscientific items. Further on extensions to geographic

  8. Skynet Junior Scholars: Bringing Astronomy to Deaf and Hard of Hearing Youth (United States)

    Meredith, Kate; Williamson, Kathryn; Gartner, Constance; Hoette, Vivian L.; Heatherly, Sue Ann


    Skynet Junior Scholars (SJS), funded by the National Science Foundation, aims to engage middle school youth from diverse audiences in investigating the universe with research quality robotic telescopes. SJS project development goals include: 1) Online access to optical and radio telescopes, data analysis tools, and professional astronomers, 2) An age-appropriate web-based interface for controlling remote telescopes, 3) Inquiry-based standards-aligned instructional modules. From an accessibility perspective, the goal of the Skynet Junior Scholars project is to facilitate independent access to the project by all youth including those with blindness or low vision and those who are Deaf or Hard of Hearing.Deaf and Hard of Hearing (DHH) students have long been an underserved population within STEM fields, including astronomy. Two main barriers include: (1) insufficient corpus of American Sign Language (ASL) for astronomy terminology, and (2) DHH education professionals who lack astronomy background. A suite of vocabulary, accessible hands-on activities, and interaction with trained professionals, are critical for enhancing the background experiences of DHH youth, as they may come to an astronomy lesson lacking the basic "incidental learning" that is often taken for granted with hearing peers (for example, from astronomy in the media).A collaboration between the Skynet Junior Scholars (SJS) project and the Wisconsin School for the Deaf is bringing astronomy to the DHH community in an accessible way for the first time. We follow a group of seven DHH youth over one semester as they interact with the SJS tools and curriculum to understand how they assimilate astronomy experiences and benefit from access to telescopes both directly (on school campus and at Yerkes Observatory) and through Skynet's robotic telescope network (optical and radio telescopes, inquiry-based modules, data analysis tools, and professional astronomers). We report on our first findings of resources and

  9. Bringing Society to a Changing Polar Ocean: Polar Interdisciplinary Coordinated Education (ICE) (United States)

    Schofield, O.


    Environmental changes in the Arctic and Antarctic appear to be accelerating and scientists are trying to understand both the patterns and the impacts of change. These changes will have profound impact on humanity and create a need for public education about these critical habitats. We have focused on a two-pronged strategy to increase public awareness as well as enable educators to discuss comfortably the implications of climate change. Our first focus is on entraining public support through the development of science documentaries about the science and people who conduct it. Antarctic Edge is a feature length award-winning documentary about climate change that has been released in May 2015 and has garnered interest in movie theatres and on social media stores (NetFlix, ITunes). This broad outreach is coupled with our group's interest assisting educators formally. The majority of current polar education is focused on direct educator engagement through personal research experiences that have impact on the participating educators' classrooms. Polar Interdisciplinary Coordinated Education (ICE) proposes to improve educator and student engagement in polar sciences through exposure to scientists and polar data. Through professional development and the creation of data tools, Polar ICE will reduce the logistical costs of bringing polar science to students in grades 6-16. We will provide opportunities to: 1) build capacity of polar scientists in communicating and engaging with diverse audiences; 2) create scalable, in-person and virtual opportunities for educators and students to engage with polar scientists and their research through data visualizations, data activities, educator workshops, webinars, and student research symposia; and 3) evaluate the outcomes of Polar ICE and contribute to our understanding of science education practices. We will use a blended learning approach to promote partnerships and cross-disciplinary sharing. This combined multi-pronged approach

  10. Rapid biodegradation of plastics by mealworms (larvae of Tenebrio molitor) brings hope to solve wasteplastic pollution (United States)

    Wu, W.; Yang, S.; Brandon, A. M.; Yang, Y.; Flanagan, J. A.; Fan, H. Q.; Cai, S. Y.; Wang, Z. Y.; Din, L. Y.; Daliang, N.; Yang, J.; Ren, J.; Tao, H. C.; Phillips, D.; Ren, N. Q.; Zhou, J.; Waymouth, R.; Criddle, C. S.


    Pollution of waste plastics in soil, river, ocean, landfill and potentially groundwater has been a major environment concern for decades. They include polystyrene (PS), polyethylene (PE) and others. Plastic particles could penetrate into groundwater and become potential threats to our groundwater Our recent research demonstrated that mealworm (larvae of Tenebrio molitor ), which are commercially used as animal and bird food and insect protein, can biodegrade PS and convert it to CO2 up within 48% within 12-14 hrs in mealworm gut. PS degradation was performed initially via depolymerization and then degradation within the mealworm guts. Gut microbiota plays a major role in PS biodegradation because the degradation is nearly completely inhibited when mealworms were fed with antibiotics. Physical and chemical analysis as well 13C labeled tests confirmed the biodegradation and mineralization of PS. The generality of plastic eating behavior of mealworms and biodegradation has been observed by testing mealworms from 11 different sources in China and the USA. All of the mealworms tested consume PS although at different relative rates. At ambient temperature (20-24 oC), the average daily consumption rate of PS ranged from 0.01 to 0.3 mg per 100 mealworms when fed PS alone. The mealworms also consumed low density polyethylene (LDPE) foam as sole diet. When mealworms were fed PS alone, the consumption rate and total amount consumed increased slightly as a function of temperature from 20 to 30 oC. Supplementing the diet with normal food (bran) enhanced the PS consumption rate and the total PS mass consumed. Microbial community analysis indicated that the microbial structure changed significantly after the diet was switched from normal food bran to PS or PS plus bran. PS-degrading bacterial strains have isolated and characterized. Our discoveries brings hopes to prevent or solve potential microplastics threats to groundwater.

  11. Bringing Ad-Hoc Analytics to Big Earth Data: the EarthServer Experience (United States)

    Baumann, Peter


    From the commonly accepted Vs defining the Big Data challenge - volume, velocity, variety - we more and more learn that the sheer volume is not the only, and often not even the decisive factor inhibiting access and analytics. In particular variety of data is a frequent core issue, posing manifold issues. Based on this observation we claim that a key aspect to analytics is the freedom to ask any questions, simple or complex, anytime and combining any choice of data structures, whatever diverging they may be. Actually, techniques for such "ad-hoc queries" we can learn from classical databases. Their concept of high-level query languages brings along several benefits: a uniform semantic, allowing machine-to-machine communication, including automatic generation of queries; massive server-side optimization and parallelization; and building attractive client interfaces hiding the query syntax from casual users while allowing power users to utilize it. However, these benefits used to be available only on tabular and set oriented data, text, and - more recently - graph data. With the advent of Array Databases, they become available on large multidimensional raster data assets as well, getting one step closer to the Holy Grail of itnegrated, uniform retrieval for users. ErthServer is a transatlantic initiative setting up operationa linfrastructures based on this paradigm. In our talk, we present core EarthServer technology concepts as well as a spectrum of Earth Science applications utilizing the EarthServer platform for versatile, visualisation supported analytics services. Further, we discuss the substantial impact EarthServer is having on Big Geo Data standardization in OGC and ISO. Time and Internet connection permitting a live demo can be presented.

  12. Bringing Internet-based education and intervention into mental health practice:

    Directory of Open Access Journals (Sweden)

    Josef I. Ruzek


    Full Text Available Internet-facilitated interventions may offer numerous advantages in reaching the large numbers of military service men and women exposed to traumatic events. The Internet is now a primary source of health-related information for consumers and research has shown the effectiveness of web-based interventions in addressing a range of mental health problems.Clinicians can learn how to bring Internet education and intervention into routine care, to help clients better understand mental health issues and learn skills for self-management of problems.The (AD Internet site can be used by health care professionals serving U.S. military personnel returning from Iraq and Afghanistan, and their families. The site currently addresses 18 key domains of functioning, including post-traumatic stress, sleep, anger, alcohol and drugs, and military sexual trauma. It provides an extensive amount of client and family education that is suitable for immediate use by clients and providers, as well as the kinds of interactive workshop content and self-assessment tools that have been shown to be helpful in other treatment contexts. AD can be utilized in clinical practice in a variety of ways: as an adjunct to treatment for PTSD, to supplement existing treatments for a range of post-deployment problems, or as the primary focus of treatment for a client.AD represents a kind of service that is likely to become increasingly available in coming years and that is important for mental health providers to actively explore as a tool for extending their reach, improving their efficiency, and improving quality of care.For the abstract or full text in other languages, please see Supplementary files under Reading Tools online.

  13. Neurological Disease Rises from Ocean to Bring Model for Human Epilepsy to Life

    Directory of Open Access Journals (Sweden)

    John S. Ramsdell


    Full Text Available Domoic acid of macroalgal origin was used for traditional and medicinal purposes in Japan and largely forgotten until its rediscovery in diatoms that poisoned 107 people after consumption of contaminated mussels. The more severely poisoned victims had seizures and/or amnesia and four died; however, one survivor unexpectedly developed temporal lobe epilepsy (TLE a year after the event. Nearly a decade later, several thousand sea lions have stranded on California beaches with neurological symptoms. Analysis of the animals stranded over an eight year period indicated five clusters of acute neurological poisoning; however, nearly a quarter have stranded individually outside these events with clinical signs of a chronic neurological syndrome similar to TLE. These poisonings are not limited to sea lions, which serve as readily observed sentinels for other marine animals that strand during domoic acid poisoning events, including several species of dolphin and whales. Acute domoic acid poisoning is five-times more prominent in adult female sea lions as a result of the proximity of their year-round breeding grounds to major domoic acid bloom events. The chronic neurological syndrome, on the other hand, is more prevalent in young animals, with many potentially poisoned in utero. The sea lion rookeries of the Channel Islands are at the crossroads of domoic acid producing harmful algal blooms and a huge industrial discharge site for dichlorodiphenyltrichloroethane (DDTs. Studies in experimental animals suggest that chronic poisoning observed in immature sea lions may result from a spatial and temporal coincidence of DDTs and domoic acid during early life stages. Emergence of an epilepsy syndrome from the ocean brings a human epilepsy model to life and provides unexpected insights into interaction with legacy contaminants and expression of disease at different life stages.

  14. The Quake-Catcher Network: Bringing Seismology to Homes and Schools (United States)

    Lawrence, J. F.; Cochran, E. S.; Christensen, C. M.; Saltzman, J.; Taber, J.; Hubenthal, M.


    The Quake-Catcher Network (QCN) is a collaborative initiative for developing the world's largest, low-cost strong-motion seismic network by utilizing sensors in and attached to volunteer internet-connected computers. QCN is not only a research tool, but provides an educational tool for teaching earthquake science in formal and informal environments. A central mission of the Quake-Catcher Network is to provide scientific educational software and hardware so that K-12 teachers, students, and the general public can better understand and participate in the science of earthquakes and earthquake hazards. With greater understanding, teachers, students, and interested individuals can share their new knowledge, resulting in continued participation in the project, and better preparation for earthquakes in their homes, businesses, and communities. The primary educational outreach goals are 1) to present earthquake science and earthquake hazards in a modern and exciting way, and 2) to provide teachers and educators with seismic sensors, interactive software, and educational modules to assist in earthquake education. QCNLive (our interactive educational computer software) displays recent and historic earthquake locations and 3-axis real-time acceleration measurements. This tool is useful for demonstrations and active engagement for all ages, from K-college. QCN provides subsidized sensors at 49 for the general public and 5 for K-12 teachers. With your help, the Quake-Catcher Network can provide better understanding of earthquakes to a broader audience. Academics are taking QCN to classrooms across the United States and around the world. The next time you visit a K-12 classroom or teach a college class on interpreting seismograms, bring a QCN sensor and QCNLive software with you! To learn how, visit

  15. Bringing Scholarship to the Classroom: Strategies for promoting research through teaching

    Directory of Open Access Journals (Sweden)

    Alisa Gaunder


    Full Text Available An issue all academics grapple with is how to strike the desired balance between research and teaching. This balance is heavily influenced by the type of institution where one seeks employment. At liberal arts colleges, excellence is expected in the classroom and a premium is put on faculty student interaction. The expectation, however, is to be teacher-scholar, not simply teacher. And indeed, the desire of most professors at liberal arts colleges is to remain active in their field. With limited time and large teaching demands, the challenge becomes one of continuously making progress on one’s research agenda. When asked to consider how to connect scholarship and teaching on the “Bringing Scholarship to the Classroom: Japan Studies” panel at the ASIANetwork conference in March 2008, I realized I had developed several strategies to link my research and teaching. What I also realized was that all these strategies were influenced by the fact that I was a junior professor vying for tenure. That is, my motivation for connecting scholarship and teaching was largely instrumental. In addition to being able to speak more passionately about topics we research and therefore engage students more fully, I would argue that finding ways to incorporate one’s research in as many classes as possible is a way to better tackle the dual role of teacher-scholar. Connecting research and teaching can accelerate one’s research agenda simply by preventing the liberal arts professor from being torn in too many different directions.

  16. Bringing the SciBar detector to the booster neutrino beam

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Arevalo, A. A.; Alcaraz, J.; Andringa, S.; Brice, S. J.; Brown, B. C.; Bugel, L.; Catala, J.; Cervera, A.; Conrad, J. M.; Couce, E.; Dore, U.; Espinal, X.; Finley, D. A.; Gomez-Cadenas, J. J.; Hayato, Y.; Hiraide, K.; Ishii, T.; Jover, G.; Kobilarcik, T.; Kurimoto, Y.; Kurosawa, Y. [et al.


    This document presents the physics case for bringing SciBar, the fully active, finely segmented tracking detector at KEK, to the FNAL Booster Neutrino Beam (BNB) line. This unique opportunity arose with the termination of K2K beam operations in 2005. At that time, the SciBar detector became available for use in other neutrino beam lines, including the BNB, which has been providing neutrinos to the MiniBooNE experiment since late 2002. The physics that can be done with SciBar/BNB can be put into three categories, each involving several measurements. First are neutrino cross section measurements which are interesting in their own right, including analyses of multi-particle final states, with unprecedented statistics. Second are measurements of processes that represent the signal and primary background channels for the upcoming T2K experiment. Third are measurements which improve existing or planned MiniBooNE analyses and the understanding of the BNB, both in neutrino and antineutrino mode. For each of these proposed measurements, the SciBar/BNB combination presents a unique opportunity or will significantly improve upon current or near-future experiments for several reasons. First, the fine granularity of SciBar allows detailed reconstruction of final states not possible with the MiniBooNE detector. Additionally, the BNB neutrino energy spectrum is a close match to the expected T2K energy spectrum in a region where cross sections are expected to vary dramatically with energy. As a result, the SciBar/BNB combination will provide cross-section measurements in an energy range complementary to MINERvA and complete the knowledge of neutrino cross sections over the entire energy range of interest to the upcoming off-axis experiments.

  17. Bringing the Excitement of Exploring Mars and the Giant Planets to Educators and the Public (United States)

    Morrow, C. A.; Dusenbery, P. B.; Harold, J.


    We are living in a wonderful era of planetary exploration. In 2004 alone, two rovers will land on Mars and the Cassini-Huygens mission will arrive in the Saturn system for an extended 4-year tour. These events will bring much public attention and provide excellent reasons for substantive educational outreach to educators and the public. The Space Science Institute (SSI) of Boulder, CO and collaborators are responding with a comprehensive array of funded and proposed projects. These include the refurbishment and redeployment of the 5000 sq. ft MarsQuest national traveling exhibition, the launch of a 600 sq. ft. "mini-MarsQuest" called Destination Mars, the launch of an interactive website called "MarsQuest Online" (in partnership with TERC and JPL), a variety of workshops for teachers, museum educators, and planetarians (in partnership with "To Mars with MER", and JPL), and the development of a "Family Guide to Mars" for use by adults and children in informal learning settings. SSI is also proposing to develop another national traveling exhibition called "Giant Planets: Exploring the Outer Solar System". This exhibit (envisioned to be 3500 sq.ft.) and its educational program will take advantage of the excitement generated by the Cassini mission and origins-related research. Its education program will also benefit from SSI having led the development of the "Saturn Educator Guide" - a JPL-sponsored resource for teachers in grades 5 and up. This paper will provide an overview of our resources in planetary science education and communicate the valuable lessons we've learned about their design, development and dissemination. SSI's educational endeavors related to planetary science have been funded by several NASA and NSF grants and contracts.

  18. Evaluation of Music And Astronomy Under The Stars: Bringing Science To New Audiences At Music Events (United States)

    Lubowich, D.; Torff, B.


    Evaluations were conducted of the 2009-2012 NASA-funded Music and Astronomy Under the Stars (MAUS) program at outdoor concerts (see the separate MAUS poster at this meeting). MAUS promoted lifelong learning by providing opportunities for the public to look through telescopes, participate in hands-on activities, and view posters, banners, and videos at events where large numbers of people are gathered. Surveys were given to 1.6% of the concertgoers at MAUS events with the participants expressing their level of agreement on a four-point scale with the following statements: “The astronomy at this event has been an enjoyable experience;” “It has been easy to comprehend the astronomy at this event;” “This event has helped me learn new things about astronomy;” “This event has made me want to learn more about astronomy;” and “This event has increased my interest in science.” On a scale where 1 = strongly disagree, 2 = disagree, 3 = agree, and 4 = strongly agree, MAUS received high ratings (>3.34/4) on all outcomes. MAUS successfully reached people at different concerts who had little interest in science. MAUS appealed to concert attendees of both genders, all ages, multiple levels of education, and all musical tastes. MAUS positively influenced the public's knowledge of and interest in astronomy. The high ratings from virtually all respondents indicate that the gains were not restricted to science enthusiasts. The data strongly supports the conclusion that MAUS—bringing astronomy to people at musical events—is effective!

  19. Bringing the ecosystem services concept into marine management decisions, supporting ecosystems-based management. (United States)

    Tweddle, J. F.; Byg, A.; Davies, I.; Gubbins, M.; Irvine, K.; Kafas, A.; Kenter, J.; MacDonald, A.; Murray, R. B. O.; Potts, T.; Slater, A. M.; Wright, K.; Scott, B. E.


    The marine environment is under increasing use, putting pressure on marine ecosystems and increasing competition for space. New activities (e.g. renewable energy developments), evolving marine policies (e.g. implementation of marine protected areas), and climate change may drive changes in biodiversity and resulting ecosystem services (ES) that society and business utilise from coastal and marine systems. A process is needed that integrates ecological assessment of changes with stakeholder perceptions and valuation of ES, whilst balancing ease of application with the ability to deal with complex social-economic-ecological issues. The project "Cooperative participatory assessment of the impact of renewable technology on ecosystem services: CORPORATES" involved natural and social scientists, law and policy experts, and marine managers, with the aim of promoting more integrated decision making using ES concepts in marine management. CORPORATES developed a process to bring ES concepts into stakeholders' awareness. The interactive process, involving 2 workshops, employs interludes of knowledge exchange by experts on ecological processes underpinning ES and on law and policy. These enable mapping of benefits linked to activities, participatory system modelling, and deliberation of policy impacts on different sectors. The workshops were attended by industry representatives, regulatory/advisory partners, and other stakeholders (NGOs, SMEs, recreationalists, local government). Mixed sector groups produced new insights into links between activities and ES, and highlighted cross-sector concerns. Here we present the aspects of the process that successfully built shared understanding between industry and stakeholders of inter-linkages and interactions between ES, benefits, activities, and economic and cultural values. These methods provide an ES-based decision-support model for exchanging societal-ecological knowledge and providing stakeholder interaction in marine planning

  20. SEA Change: Bringing together Science, Engineering and the Arts at the University of Florida (United States)

    Perfit, M. R.; Mertz, M. S.; Lavelli, L.


    A group of interested and multifaceted faculty, administrators and students created the Science, Engineering, Arts Committee (SEA Change) two years ago at the University of Florida (UF). Recognizing that innovative ideas arise from the convergence of divergent thinkers, the committee seeks to bring together faculty in Science, Engineering, the Arts and others across campus to develop and disseminate innovative ideas for research, teaching and service that will enhance the campus intellectual environment. We meet regularly throughout the year as faculty with graduate and undergraduate students to catalyze ideas that could lead to collaborative or interdisciplinary projects and make recommendations to support innovative, critical and creative work. As an example, the Department of Geological Sciences and the School of Art and Art History collaborated on a competition among UF undergraduate painting students to create artistic works that related to geoscience. Each student gathered information from Geological Sciences faculty members to use for inspiration in creating paintings along with site-specific proposals to compete for a commission. The winning work was three-story high painting representing rock strata and the Florida environment entitled "Prairie Horizontals" that is now installed in the Geoscience building entrance atrium. Two smaller paintings of the second place winner, depicting geologists in the field were also purchased and displayed in a main hallway. Other activities supported by SEA Change have included a collaborative work of UF engineering and dance professors who partnered for the Creative Storytelling and Choreography Lab, to introduce basic storytelling tools to engineering students. A campus-wide gathering of UF faculty and graduate students titled Creative Practices: The Art & Science of Discovery featured guest speakers Steven Tepper, Victoria Vesna and Benjamin Knapp in spring 2014. The Committee plans to develop and foster ideas that will

  1. Practical lessons for bringing policy-makers on board in sexual and reproductive health research. (United States)

    Guieu, Aurore; Zhang, Wei-Hong; Lafort, Yves; Decat, Peter; De Meyer, Sara; Wang, Shuchen; Kerstens, Birgit; Duysburgh, Els


    The need to translate research into policy, i.e. making research findings a driving force in agenda-setting and policy change, is increasingly acknowledged. However, little is known about translation mechanisms in the field of sexual and reproductive health (SRH) outside North American or European contexts. This paper seeks to give an overview of the existing knowledge on this topic as well as to document practical challenges and remedies from the perspectives of researchers involved in four SRH research consortium projects in Latin America, sub-Saharan Africa, China and India. A literature review and relevant project documents were used to develop an interview guide through which researchers could reflect on their experiences in engaging with policy-makers, and particularly on the obstacles met and the strategies deployed by the four project consortia to circumvent them. Our findings confirm current recommendations on an early and steady involvement of policy-makers, however they also suggest that local barriers between researchers and policy-making spheres and individuals can represent major hindrances to the realization of translation objectives. Although many of the challenges might be common to different contexts, creating locally-adapted responses is deemed key to overcome them. Researchers' experiences also indicate that - although inevitable - recognizing and addressing these challenges is a difficult, time- and energy-consuming process for all partners involved. Despite a lack of existing knowledge on translation efforts in SRH research outside North American or European contexts, and more particularly in low and middle-income countries, it is clear that existing pressure on health and policy systems in these settings further complicates them. This article brings together literature findings and researchers' own experiences in translating research results into policy and highlights the major challenges research conducted on sexual and reproductive health

  2. The Relationship between Teachers' Computer Self-Efficacy and Technology Integration in a School District's Bring Your Own Technology Initiative (United States)

    Ellis, Ashley F.


    The purpose of this mixed methods program evaluation study was to investigate the ways in which one public school district and its teachers implemented a Bring Your Own Technology (BYOT) initiative. This study also measured teachers' computer self-efficacy, as measured by Cassidy and Eachus' (2002) Computer User Self-Efficacy Scale, and…

  3. Genomic-Based Health Care in Nursing: A Bidirectional Approach to Bringing Genetics into Nursing's Body of Knowledge. (United States)

    Lea, Dale Halsey; Feetham, Suzanne L.; Monsen, Rita Black


    A survey of 15 genetics nurses reveals both grassroots and top-down approaches to advancing genetics in nursing practice, research, and education. As genome-based health care spreads, nursing should concentrate on bringing genetics into clinical practice and scholarship. (Contains 33 references.) (SK)

  4. Bringing Female Scientists into the Elementary Classroom: Confronting the Strength of Elementary Students' Stereotypical Images of Scientists. (United States)

    Buck, Gayle A.; Leslie-Pelecky, Diandra; Kirby, Susan K.


    Explores the effectiveness of bringing female scientists into elementary classrooms to promote change in the stereotypical images of scientists. Indicates that despite the efforts of the scientists to encourage students to question their image of a scientist, students held onto stereotypical images. Uses both qualitative and quantitative methods…

  5. Bringing Science to Bear--On Peace, Not War: Elaborating on Psychology's Potential to Promote Peace (United States)

    Leidner, Bernhard; Tropp, Linda R.; Lickel, Brian


    We argue that psychological and contextual factors play important roles in bringing about, facilitating, and escalating violent conflict. Yet rather than conclude that violent conflict is inevitable, we believe psychology's contributions can extend beyond understanding the origins and nature of violent conflict, to promote nonviolence and…

  6. The Mark of a Leader: Longevity, Strategic Planning and Vision Bring Academic and Financial Success to Xavier (United States)

    Cooper, Kenneth J.


    This article profiles Dr. Norman Francis and describes how his longevity, strategic planning and vision as president of Xavier University bring academic and financial success. Higher education leaders say his 43 years at the Catholic HBCU in New Orleans is an increasingly rare example of the benefits possible from a lengthy presidency. It takes…

  7. Mobilizing Communities around HIV Prevention for Youth: How Three Coalitions Applied Key Strategies to Bring about Structural Changes (United States)

    Chutuape, Kate S.; Willard, Nancy; Sanchez, Kenia; Straub, Diane M.; Ochoa, Tara N.; Howell, Kourtney; Rivera, Carmen; Ramos, Ibrahim; Ellen, Jonathan M.


    Increasingly, HIV prevention efforts must focus on altering features of the social and physical environment to reduce risks associated with HIV acquisition and transmission. Community coalitions provide a vehicle for bringing about sustainable structural changes. This article shares lessons and key strategies regarding how three community…

  8. Managing biological diversity (United States)

    Samson, Fred B.; Knopf, Fritz L.


    Biological diversity is the variety of life and accompanying ecological processes (Off. Technol. Assess. 1987, Wilcove and Samson 1987, Keystone 1991). Conservation of biological diversity is a major environmental issue (Wilson 1988, Counc. Environ. Quality 1991). The health and future of the earth's ecological systems (Lubchenco et al. 1991), global climate change (Botkin 1990), and an ever-increasing rate in loss of species, communities, and ecological systems (Myers 1990) are among issues drawing biological diversity to the mainstream of conservation worldwide (Int. Union Conserv. Nat. and Nat. Resour. [IUCN] et al. 1991). The legal mandate for conserving biological diversity is now in place (Carlson 1988, Doremus 1991). More than 19 federal laws govern the use of biological resources in the United States (Rein 1991). The proposed National Biological Diversity Conservation and Environmental Research Act (H.R. 585 and S.58) notes the need for a national biological diversity policy, would create a national center for biological diversity research, and recommends a federal interagency strategy for ecosystem conservation. There are, however, hard choices ahead for the conservation of biological diversity, and biologists are grappling with how to set priorities in research and management (Roberts 1988). We sense disillusion among field biologists and managers relative to how to operationally approach the seemingly overwhelming charge of conserving biological diversity. Biologists also need to respond to critics like Hunt (1991) who suggest a tree farm has more biological diversity than an equal area of old-growth forest. At present, science has played only a minor role in the conservation of biological diversity (Weston 1992) with no unified approach available to evaluate strategies and programs that address the quality and quantity of biological diversity (Murphy 1990, Erwin 1992). Although actions to conserve biological diversity need to be clearly defined by

  9. Systems biology in animal sciences


    Woelders, H.; Pas, te, M.F.W.; Bannink, A.; Veerkamp, R. F.; Smits, M A


    Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes and animal traits are not yet frequently used. This paper aims to explain what systems biology is and which areas of animal sciences could benefit from systems biology approaches. Systems biology aim...

  10. Biological and Chemical Security

    Energy Technology Data Exchange (ETDEWEB)

    Fitch, P J


    The LLNL Chemical & Biological National Security Program (CBNP) provides science, technology and integrated systems for chemical and biological security. Our approach is to develop and field advanced strategies that dramatically improve the nation's capabilities to prevent, prepare for, detect, and respond to terrorist use of chemical or biological weapons. Recent events show the importance of civilian defense against terrorism. The 1995 nerve gas attack in Tokyo's subway served to catalyze and focus the early LLNL program on civilian counter terrorism. In the same year, LLNL began CBNP using Laboratory-Directed R&D investments and a focus on biodetection. The Nunn-Lugar-Domenici Defense Against Weapons of Mass Destruction Act, passed in 1996, initiated a number of U.S. nonproliferation and counter-terrorism programs including the DOE (now NNSA) Chemical and Biological Nonproliferation Program (also known as CBNP). In 2002, the Department of Homeland Security was formed. The NNSA CBNP and many of the LLNL CBNP activities are being transferred as the new Department becomes operational. LLNL has a long history in national security including nonproliferation of weapons of mass destruction. In biology, LLNL had a key role in starting and implementing the Human Genome Project and, more recently, the Microbial Genome Program. LLNL has over 1,000 scientists and engineers with relevant expertise in biology, chemistry, decontamination, instrumentation, microtechnologies, atmospheric modeling, and field experimentation. Over 150 LLNL scientists and engineers work full time on chemical and biological national security projects.

  11. Physics in Molecular Biology (United States)

    Sneppen, Kim; Zocchi, Giovanni


    Tools developed by statistical physicists are of increasing importance in the analysis of complex biological systems. Physics in Molecular Biology discusses how physics can be used in modeling life. It begins by summarizing important biological concepts, emphasizing how they differ from the systems normally studied in physics. A variety of topics, ranging from the properties of single molecules to the dynamics of macro-evolution, are studied in terms of simple mathematical models. The main focus of the book is on genes and proteins and how they build systems that compute and respond. The discussion develops from simple to complex systems, and from small-scale to large-scale phenomena. This book will inspire advanced undergraduates and graduate students in physics to approach biological subjects from a physicist's point of view. It is self-contained, requiring no background knowledge of biology, and only familiarity with basic concepts from physics, such as forces, energy, and entropy. Introduces important biological concepts from a physicist's point of view - no background knowledge of biology is required A wide range of subjects are studied using simple mathematical models; exercises are included Discussion develops from simple to complex phenomena and from small scale to large scale interactions

  12. Noise in biological circuits. (United States)

    Simpson, Michael L; Cox, Chris D; Allen, Michael S; McCollum, James M; Dar, Roy D; Karig, David K; Cooke, John F


    Noise biology focuses on the sources, processing, and biological consequences of the inherent stochastic fluctuations in molecular transitions or interactions that control cellular behavior. These fluctuations are especially pronounced in small systems where the magnitudes of the fluctuations approach or exceed the mean value of the molecular population. Noise biology is an essential component of nanomedicine where the communication of information is across a boundary that separates small synthetic and biological systems that are bound by their size to reside in environments of large fluctuations. Here we review the fundamentals of the computational, analytical, and experimental approaches to noise biology. We review results that show that the competition between the benefits of low noise and those of low population has resulted in the evolution of genetic system architectures that produce an uneven distribution of stochasticity across the molecular components of cells and, in some cases, use noise to drive biological function. We review the exact and approximate approaches to gene circuit noise analysis and simulation, and review many of the key experimental results obtained using flow cytometry and time-lapse fluorescent microscopy. In addition, we consider the probative value of noise with a discussion of using measured noise properties to elucidate the structure and function of the underlying gene circuit. We conclude with a discussion of the frontiers of and significant future challenges for noise biology. (c) 2009 John Wiley & Sons, Inc.

  13. Neutron in biology

    Energy Technology Data Exchange (ETDEWEB)

    Niimura, Nobuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment


    Neutron in biology can provide an experimental method of directly locating relationship of proteins and DNA. However, there are relatively few experimental study of such objects since it takes a lot of time to collect a sufficient number of Bragg reflections and inelastic spectra due to the low flux of neutron illuminating the sample. Since a next generation neutron source of JAERI will be 5MW spallation neutron source and its effective neutron flux will be 10{sup 2} to 10{sup 3} times higher than the one of JRR-3M, neutron in biology will open a completely new world for structural biology. (author)

  14. 2010 Plant Molecular Biology Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Michael Sussman


    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.

  15. Structure–Activity Relationship of Oligomeric Flavan-3-ols: Importance of the Upper-Unit B-ring Hydroxyl Groups in the Dimeric Structure for Strong Activities

    Directory of Open Access Journals (Sweden)

    Yoshitomo Hamada


    Full Text Available Proanthocyanidins, which are composed of oligomeric flavan-3-ol units, are contained in various foodstuffs (e.g., fruits, vegetables, and drinks and are strongly biologically active compounds. We investigated which element of the proanthocyanidin structure is primarily responsible for this functionality. In this study, we elucidate the importance of the upper-unit of 4–8 condensed dimeric flavan-3-ols for antimicrobial activity against Saccharomyces cerevisiae (S. cerevisiae and cervical epithelioid carcinoma cell line HeLa S3 proliferation inhibitory activity. To clarify the important constituent unit of proanthocyanidin, we synthesized four dimeric compounds, (−-epigallocatechin-[4,8]-(+-catechin, (−-epigallocatechin-[4,8]-(−-epigallocatechin, (−-epigallocatechin-[4,8]-(−-epigallocatechin-3-O-gallate, and (+-catechin-[4,8]-(−-epigallocatechin and performed structure–activity relationship (SAR studies. In addition to antimicrobial activity against S. cerevisiae and proliferation inhibitory activity on HeLa S3 cells, the correlation of 2,2-diphenyl-l-picrylhydrazyl radical scavenging activity with the number of phenolic hydroxyl groups was low. On the basis of the results of our SAR studies, we concluded that B-ring hydroxyl groups of the upper-unit of the dimer are crucially important for strong and effective activity.

  16. Advances in metabolome information retrieval: turning chemistry into biology. Part II: biological information recovery. (United States)

    Tebani, Abdellah; Afonso, Carlos; Bekri, Soumeya


    This work reports the second part of a review intending to give the state of the art of major metabolic phenotyping strategies. It particularly deals with inherent advantages and limits regarding data analysis issues and biological information retrieval tools along with translational challenges. This Part starts with introducing the main data preprocessing strategies of the different metabolomics data. Then, it describes the main data analysis techniques including univariate and multivariate aspects. It also addresses the challenges related to metabolite annotation and characterization. Finally, functional analysis including pathway and network strategies are discussed. The last section of this review is devoted to practical considerations and current challenges and pathways to bring metabolomics into clinical environments.

  17. Laboratory of Biological Modeling (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to a...

  18. Hammond Bay Biological Station (United States)

    Federal Laboratory Consortium — Hammond Bay Biological Station (HBBS), located near Millersburg, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). HBBS was established by...

  19. Biological and Pharmacological properties

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Biological and Pharmacological properties. NOEA inhibits Ceramidase. Anandamide inhibits gap junction conductance and reduces sperm fertilizing capacity. Endogenous ligands for Cannabinoid receptors (anandamide and NPEA). Antibacterial and antiviral ...

  20. Fishery Biology Database (AGDBS) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Basic biological data are the foundation on which all assessments of fisheries resources are built. These include parameters such as the size and age composition of...

  1. Biological Monitoring Team (United States)

    US Fish and Wildlife Service, Department of the Interior — The Biological Monitoring Team (BMT) was a pilot project focused on addressing NWRS inventory and monitoring needs in Regions 3 and 5. The BMT was a precursor to the...

  2. Biology of spiders

    National Research Council Canada - National Science Library

    Foelix, Rainer F


    "One of the only books to treat the whole spider, from its behavior and physiology to its neurobiology and reproductive characteristics, Biology of Spiders is considered a classic in spider literature...

  3. Nutritional Systems Biology

    DEFF Research Database (Denmark)

    Jensen, Kasper

    and network biology has the potential to increase our understanding of how small molecules affect metabolic pathways and homeostasis, how this perturbation changes at the disease state, and to what extent individual genotypes contribute to this. A fruitful strategy in approaching and exploring the field...... biology research. The paper also shows as a proof-of-concept that a systems biology approach to diet is meaningful and demonstrates some basic principles on how to work with diet systematic. The second chapter of this thesis we developed the resource NutriChem v1.0. A foodchemical database linking...... sites of diet on the disease pathway. We propose a framework for interrogating the critical targets in colon cancer process and identifying plant-based dietary interventions as important modifiers using a systems chemical biology approach. The fifth chapter of the thesis is on discovering of novel anti...

  4. Large Pelagics Biological Survey (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Large Pelagics Biological Survey (LPBS) collects additional length and weight information and body parts such as otoliths, caudal vertebrae, dorsal spines, and...

  5. ERLN Biological Focus Area (United States)

    The Environmental Response Laboratory Network supports the goal to increase national capacity for biological analysis of environmental samples. This includes methods development and verification, technology transfer, and collaboration with USDA, FERN, CDC.

  6. Multiscale Biological Materials

    DEFF Research Database (Denmark)

    Frølich, Simon

    Materials formed by organisms, also known as biological materials, exhibit outstanding structural properties. The range of materials formed in nature is remarkable and their functions include support, protection, motion, sensing, storage, and maintenance of physiological homeostasis. These complex...... materials are characterized by their hierarchical and composite design, where features with sizes ranging from nanometers to centimeters provide the basis for the functionality of the material. Understanding of biological materials is, while very interesting from a basic research perspective, also valuable...... as inspiration for the development of new materials for medical and technological applications. In order to successfully mimic biological materials we must first have a thorough understanding of their design. As such, the purpose of the characterization of biological materials can be defined as the establishment...

  7. Teaching evolutionary biology

    Directory of Open Access Journals (Sweden)

    Rosana Tidon


    Full Text Available Evolutionary Biology integrates several disciplines of Biology in a complex and interactive manner, where a deep understanding of the subject demands knowledge in diverse areas. Since this knowledge is often inaccessible to the majority of specialized professionals, including the teachers, we present some reflections in order to stimulate discussions aimed at the improvement of the conditions of education in this area. We examine the profile of evolutionary teaching in Brazil, based on questionnaires distributed to teachers in Secondary Education in the Federal District, on data provided by the "National Institute for Educational Studies and Research", and on information collected from teachers working in various regions of this country. Issues related to biological misconceptions, curriculum and didactic material are discussed, and some proposals are presented with the objective of aiding discussions aimed at the improvement of the teaching of evolutionary biology.

  8. Enhanced Biological Sampling Data (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is a database of a variety of biological, reproductive, and energetic data collected from fish on the continental shelf in the northwest Atlantic Ocean. Species...

  9. Human papillomavirus molecular biology. (United States)

    Harden, Mallory E; Munger, Karl

    Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Complex systems biology


    Ma'ayan, Avi


    Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I outline general design principles identified in many complex s...

  11. Graphs in molecular biology

    Directory of Open Access Journals (Sweden)

    Falcon Seth


    Full Text Available Abstract Graph theoretical concepts are useful for the description and analysis of interactions and relationships in biological systems. We give a brief introduction into some of the concepts and their areas of application in molecular biology. We discuss software that is available through the Bioconductor project and present a simple example application to the integration of a protein-protein interaction and a co-expression network.

  12. Ratiometric biological nanosensors. (United States)

    Fisher, Kate M; Campbell, Colin J


    The measurement of intracellular analytes has been key in understanding cellular processes and function, and the use of biological nanosensors has revealed the spatial and temporal variation in their concentrations. In particular, ratiometric nanosensors allow quantitative measurements of analyte concentrations. The present review focuses on the recent advances in ratiometric intracellular biological nanosensors, with an emphasis on their utility in measuring analytes that are important in cell function.

  13. What does the implementation of IFRS for SMEs bring for agricultural enterprises?

    Directory of Open Access Journals (Sweden)

    Hana Bohušová


    Full Text Available Agricultural activity is largely different from other activities that the entities perform in order to achieve profit. Unlike other business entities, agricultural produce is significantly dependent on natural climatic conditions, and therefore a particular specialization of agricultural produce depends on geographic location. Agricultural producers use every form of business organization, from small farms to large publicly held corporations. Although most entrepreneurs working in agriculture are small and medium enterprises, the specifics of agriculture are significantly reflected in the financial reporting intended primarily for large corporations traded on the capital markets. Aim of this paper is to review the possibilities of implementation of the provisions relating to agriculture in the frame of IFRS for SMEs into practice of entities concerned whose object is agricultural production and to recommend appropriate application in practice. There are designed specific procedures of recording in relation to the nature of biological assets and agricultural produce and ways of measurement in this paper. The nature of biological assets is considered as distinguishing criterion (consumable assets, bearer assets and consumable assets with long production cycle.

  14. Tissue vascularization through 3D printing: Will technology bring us flow? (United States)

    Paulsen, S J; Miller, J S


    Though in vivo models provide the most physiologically relevant environment for studying tissue function, in vitro studies provide researchers with explicit control over experimental conditions and the potential to develop high throughput testing methods. In recent years, advancements in developmental biology research and imaging techniques have significantly improved our understanding of the processes involved in vascular development. However, the task of recreating the complex, multi-scale vasculature seen in in vivo systems remains elusive. 3D bioprinting offers a potential method to generate controlled vascular networks with hierarchical structure approaching that of in vivo networks. Bioprinting is an interdisciplinary field that relies on advances in 3D printing technology along with advances in imaging and computational modeling, which allow researchers to monitor cellular function and to better understand cellular environment within the printed tissue. As bioprinting technologies improve with regards to resolution, printing speed, available materials, and automation, 3D printing could be used to generate highly controlled vascularized tissues in a high throughput manner for use in regenerative medicine and the development of in vitro tissue models for research in developmental biology and vascular diseases. © 2015 Wiley Periodicals, Inc.

  15. Bringing Terra Science to the People: 10 years of education and public outreach (United States)

    Riebeek, H.; Chambers, L. H.; Yuen, K.; Herring, D.


    The default image on Apple's iPhone is a blue, white, green and tan globe: the Blue Marble. The iconic image was produced using Terra data as part of the mission's education and public outreach efforts. As far-reaching and innovative as Terra science has been over the past decade, Terra education and public outreach efforts have been equally successful. This talk will provide an overview of Terra's crosscutting education and public outreach projects, which have reached into educational facilities—classrooms, museums, and science centers, across the Internet, and into everyday life. The Earth Observatory web site was the first web site designed for the public that told the unified story of what we can learn about our planet from all space-based platforms. Initially conceived as part of Terra mission outreach in 1999, the web site has won five Webby awards, the highest recognition a web site can receive. The Visible Earth image gallery is a catalogue of NASA Earth imagery that receives more than one million page views per month. The NEO (NASA Earth Observations) web site and WMS (web mapping service) tool serves global data sets to museums and science centers across the world. Terra educational products, including the My NASA Data web service and the Students' Cloud Observations Online (S'COOL) project, bring Terra data into the classroom. Both projects target multiple grade levels, ranging from elementary school to graduate school. S'COOL uses student observations of clouds to help validate Terra data. Students and their parents have puzzled over weekly "Where on Earth" geography quizzes published on line. Perhaps the most difficult group to reach is the large segment of the public that does not seek out science information online or in a science museum or classroom. To reach these people, EarthSky produced a series of podcasts and radio broadcasts that brought Terra science to more than 30 million people in 2009. Terra imagery, including the Blue Marble, have

  16. A Groundwater project for K-12 schools: Bringing research into the classroom (United States)

    Rodak, C. M.; Walsh, M.; Gensic, J.


    Simple water quality test kits were used in a series of K-12 classrooms to demonstrate scientific processes and to motivate learning in K-12 students. While focused on student learning, this project also allowed collection of regional data on groundwater quality (primarily nitrate) in the study area. The project consisted of development and administration of a weeklong groundwater quality unit introduced to K-12 schools in northern Indiana and taught by a graduate student in an engineering discipline. The structure of the week started with an introduction to basic groundwater concepts modified for the specific grade level; for this project the students ranged from grades 4-12. In addition to groundwater basics, the purpose of the collection of the water quality data, as well as relevance to the research of the graduate student, were outlined. The students were then: (i) introduced to two simple water quality testing methods for nitrates, (ii) required to hypothesize as to which method will likely be "better" in application, and (iii) asked to practice using these two methods under laboratory conditions. Following practice, the students were asked to discuss their hypotheses relative to what was observed during the practice focusing on which testing method was more accurate and/or precise. The students were then encouraged to bring water samples from their home water system (many of which are on private wells) to analyze within groups. At the end of the week, the students shared their experience in this educational effort, as well as the resulting nitrate data from numerous groundwater wells (as collected by the students). Following these discussions the data were added to an online database housed on a wiki sponsored by the Notre Dame Extended Research Community ( These data were plotted using the free service MapAList to visually demonstrate to the students the spatial distribution of the data and how their results have

  17. Bringing a Global Issue Closer to Home: The OSU Climate Change Webinar Series (United States)

    Jentes Banicki, J.; Dierkes, C.


    When people think about the effects of climate change, many will still picture that iconic lone polar bear clinging to a shrinking iceberg in Antarctica. But many don't realize that the impacts that we will face here at home could also be severe, directly affecting the food we eat, the health we have, and the natural environments we appreciate. To help better explain and ultimately localize those impacts for Great Lakes residents, 10 departments within Ohio State University partnered in 2009 to create the Global Change, Local Impact webinar series. The monthly series brings in experts from around the Great Lakes region to discuss issues and impacts we will encounter regionally as our climate changes. Originally designed as a small series for Ohioans, the series has broadened to focus on Great Lakes-related issues, with more than 4,500 attendees representing 500 organizations in governmental agencies, academia, non-profit groups, private industry, and the legislature from around the country. Over the past two years, the OSU Climate Team expanded its educational reach by partnering with external groups like the Centers for Disease Control and Prevention, Great Lakes Regional Water Program, National Oceanic and Atmospheric Administration, and the Great Lakes Sea Grant Network to help deliver the most knowledgeable experts and resources for each Great Lake-focused climate topic and archive those resources on its web site. As a result of these collaborative efforts, participants say the webinars are one of their primary resources for climate-related research information in the region, with 80-90% polled saying they use this information as an unbiased resource to help not only understand how climate change could affect local concerns like public health, agriculture, and infrastructure, but what they in their vocations and daily lives can do to prepare for it. For scientists and practitioners, this series serves as the perfect low carbon venue

  18. Bringing a Chemical Laboratory Named Sam to Mars on the 2011 Curiosity Rover (United States)

    Mahaffy, P. R.; Bleacher, L.; Jones, A.; Atreya, S. K.; Manning, H. L.; Cabane, M.; Webster, C. R.; Sam Team


    for the ChemMatters journal that is widely distributed to high school students. Informal education activities include professional development telecons for the NASA Museum Alliance and development of a landing site selection activity that will bring to the attention of students and the public the interesting work done by Mars scientists who study the best locations for Curiostiy to explore. Each of these products can be used by interested groups and venues wishing to participate in the Year of the Solar System. References: [1] Mahaffy, P.R., Space Sci. Rev. 135, 255 (2008). [2] Mahaffy, P.R. (2009) Geochem. News, 121. Acknowledgement: Funding for the SAM development was provided by NASA through the MSL Project and for the GC from the CNES.

  19. Project ASTRO NOVA brings Standard Based Astronomy to New Jersey Schools. (United States)

    van der Veen, W.; Vinski, J.; Gallagher, A. C.


    Begun in 1998, Project ASTRO NOVA is hosted by the Planetarium at Raritan Valley Community College in Somerville, New Jersey. It is part of a National Network of eleven Project ASTRO sites created by the Astronomical Society of the Pacific with financial support of the National Science Foundation (see other papers at this meeting). Our goal is to bring hands-on inquiry based astronomy into classrooms and help teachers meet the New Jersey Science Standards. New Jersey mandates the teaching of astronomy in grades K-12 and statewide assessment takes place in grades 4 and 8. Capitalizing on New Jersey's record number of amateur astronomers per capita our site has trained 75 astronomers (including 21 professional astronomers) over the last three years. Before the start of each school year a new group of astronomers is trained together with their partner teacher(s) in the use of hands-on and age-appropriate astronomy activities that support the New Jersey Science Standards. Astronomers adopt a classroom and visit the same students at least four times during the year. Currently 53 astronomers are participating during the 2000-2001 school year. The program in New Jersey targets teachers in grades 3-9. A total of 114 teachers have been training at our annual workshops and 75 of them are participating during the 2000-2001 school year. Satisfaction with the program has been high with students, teachers and astronomers. When students meet scientists as role models and experience that doing science can be a lot of fun they become more interested. At the same time teachers are re-energized and gain a better understanding of how to teach science and astronomy. Finally, astronomers have the satisfaction of making a real difference in the lives of thousands of children, gain a better understanding of the issues in K-12 education and learn new teaching strategies for use in their college classes or astronomy clubs. In general we find that students and teachers are becoming better

  20. Bringing Legacy Visualization Software to Modern Computing Devices via Application Streaming (United States)

    Fisher, Ward


    Planning software compatibility across forthcoming generations of computing platforms is a problem commonly encountered in software engineering and development. While this problem can affect any class of software, data analysis and visualization programs are particularly vulnerable. This is due in part to their inherent dependency on specialized hardware and computing environments. A number of strategies and tools have been designed to aid software engineers with this task. While generally embraced by developers at 'traditional' software companies, these methodologies are often dismissed by the scientific software community as unwieldy, inefficient and unnecessary. As a result, many important and storied scientific software packages can struggle to adapt to a new computing environment; for example, one in which much work is carried out on sub-laptop devices (such as tablets and smartphones). Rewriting these packages for a new platform often requires significant investment in terms of development time and developer expertise. In many cases, porting older software to modern devices is neither practical nor possible. As a result, replacement software must be developed from scratch, wasting resources better spent on other projects. Enabled largely by the rapid rise and adoption of cloud computing platforms, 'Application Streaming' technologies allow legacy visualization and analysis software to be operated wholly from a client device (be it laptop, tablet or smartphone) while retaining full functionality and interactivity. It mitigates much of the developer effort required by other more traditional methods while simultaneously reducing the time it takes to bring the software to a new platform. This work will provide an overview of Application Streaming and how it compares against other technologies which allow scientific visualization software to be executed from a remote computer. We will discuss the functionality and limitations of existing application streaming

  1. Plant and bacterial systems biology as platform for plant synthetic bio(techno)logy. (United States)

    Zurbriggen, Matias D; Moor, Alina; Weber, Wilfried


    The recent implementation of various high-throughput biochemical and bioanalytical platforms for the study of biological systems has resulted in a wealth of experimental information that systems biology integrates into models and functional descriptions of organisms. The fast tempo of systems biology development is currently bringing in a revolution in the understanding of cell networks by providing with a holistic comprehension of cellular components and their interaction dynamics. This thorough description of biological systems has laid the grounds for the development of synthetic biology, a discipline applying basic principles of engineering for the rational assembly of biological modules into higher order complex biological systems with desired properties. Despite the success of this new field for the generation of biotechnological tools, it has not been yet widely applied to plant systems. This review aims at describing the current status of systems biology, its contribution to our understanding of plant metabolism, expression and regulatory networks and how synthetic biology approaches could benefit utilising plant and bacterial 'omics' as a source for the design and development of biological modules for the improvement of plant stress tolerance and crop production, among other applications. The article further describes synthetic biology strategies currently being applied to plant metabolic engineering, development of signalling pathways and synthetic organelles, and the potential of this new field for the understanding of plant cellular functioning and the generation of plant biotechnological tools. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. Developmental biology, the stem cell of biological disciplines. (United States)

    Gilbert, Scott F


    Developmental biology (including embryology) is proposed as "the stem cell of biological disciplines." Genetics, cell biology, oncology, immunology, evolutionary mechanisms, neurobiology, and systems biology each has its ancestry in developmental biology. Moreover, developmental biology continues to roll on, budding off more disciplines, while retaining its own identity. While its descendant disciplines differentiate into sciences with a restricted set of paradigms, examples, and techniques, developmental biology remains vigorous, pluripotent, and relatively undifferentiated. In many disciplines, especially in evolutionary biology and oncology, the developmental perspective is being reasserted as an important research program.

  3. FDA 101: Regulating Biological Products (United States)

    ... Products For Consumers Home For Consumers Consumer Updates FDA 101: Regulating Biological Products Share Tweet Linkedin Pin ... and highly important field. What biological products does FDA regulate? The Center for Biologics Evaluation and Research ( ...

  4. [Biologics and mycobacterial diseases]. (United States)

    Tsuyuguchi, Kazunari; Matsumoto, Tomoshige


    Various biologics such as TNF-alpha inhibitor or IL-6 inhibitor are now widely used for treatment of rheumatoid arthritis. Many reports suggested that one of the major issues is high risk of developing tuberculosis (TB) associated with using these agents, which is especially important in Japan where tuberculosis still remains endemic. Another concern is the risk of development of nontuberculous mycobacterial (NTM) diseases and we have only scanty information about it. The purpose of this symposium is to elucidate the role of biologics in the development of mycobacterial diseases and to establish the strategy to control them. First, Dr. Tohma showed the epidemiologic data of TB risks associated with using biologics calculated from the clinical database on National Database of Rheumatic Diseases by iR-net in Japan. He estimated TB risks in rheumatoid arthritis (RA) patients to be about four times higher compared with general populations and to become even higher by using biologics. He also pointed out a low rate of implementation of QuantiFERON test (QFT) as screening test for TB infection. Next, Dr. Tokuda discussed the issue of NTM disease associated with using biologics. He suggested the airway disease in RA patients might play some role in the development of NTM disease, which may conversely lead to overdiagnosis of NTM disease in RA patients. He suggested that NTM disease should not be uniformly considered a contraindication to treatment with biologics, considering from the results of recent multicenter study showing relatively favorable outcome of NTM patients receiving biologics. Patients with latent tuberculosis infection (LTBI) should receive LTBI treatment before starting biologics. Dr. Kato, a chairperson of the Prevention Committee of the Japanese Society for Tuberculosis, proposed a new LTBI guideline including active implementation of LTBI treatment, introducing interferon gamma release assay, and appropriate selection of persons at high risk for

  5. Biological process linkage networks.

    Directory of Open Access Journals (Sweden)

    Dikla Dotan-Cohen

    Full Text Available The traditional approach to studying complex biological networks is based on the identification of interactions between internal components of signaling or metabolic pathways. By comparison, little is known about interactions between higher order biological systems, such as biological pathways and processes. We propose a methodology for gleaning patterns of interactions between biological processes by analyzing protein-protein interactions, transcriptional co-expression and genetic interactions. At the heart of the methodology are the concept of Linked Processes and the resultant network of biological processes, the Process Linkage Network (PLN.We construct, catalogue, and analyze different types of PLNs derived from different data sources and different species. When applied to the Gene Ontology, many of the resulting links connect processes that are distant from each other in the hierarchy, even though the connection makes eminent sense biologically. Some others, however, carry an element of surprise and may reflect mechanisms that are unique to the organism under investigation. In this aspect our method complements the link structure between processes inherent in the Gene Ontology, which by its very nature is species-independent. As a practical application of the linkage of processes we demonstrate that it can be effectively used in protein function prediction, having the power to increase both the coverage and the accuracy of predictions, when carefully integrated into prediction methods.Our approach constitutes a promising new direction towards understanding the higher levels of organization of the cell as a system which should help current efforts to re-engineer ontologies and improve our ability to predict which proteins are involved in specific biological processes.

  6. Biological Effects of Ionizing Radiation (United States)

    Ingram, M.; Mason, W. B.; Whipple, G. H.; Howland, J. W.


    This report presents a review of present knowledge and concepts of the biological effects of ionizing radiations. Among the topics discussed are the physical and chemical effects of ionizing radiation on biological systems, morphological and physiological changes observed in biological systems subjected to ionizing radiations, physiological changes in the intact animal, latent changes following exposure of biological systems to ionizing radiations, factors influencing the biological response to ionizing radiation, relative effects of various ionizing radiations, and biological dosimetry.

  7. From biologically-inspired physics to physics-inspired biology From biologically-inspired physics to physics-inspired biology (United States)

    Kornyshev, Alexei A.


    discovery was the 'chemistry' between an enthusiastic biologist (Watson) and physicist (Crick) that helped them to find common language, and as a result discover not only the structure but also the 'function' of DNA. Now we know that the machinery of DNA replication is very complex, promoted by motor proteins such as DNA helicase, polymerase, ligases etc, but the complementary principle of synthesis of two identical DNA molecules on the unwound complimentary single strands as templates remains the same as mentioned in the famous phrase ('It did not escape our attention') of the first Watson-Crick paper. Dogma 4: (Almost literally from a letter from Don Roy Forsdyke, Biochemistry Professor at Queens Ontario). 'Biologists will not read a paper with formulae. The biological literature is vast. Biologists have too many papers to read and too many experiments to make. They will leave aside any reading that looks difficult'. If this is true, and I think it is, we are in big trouble; this brings us to the next dogma. Dogma 5: (Catch 22) It is impossible to publish a serious theoretical paper in a biological journal. Physicists, particularly, theorists need derivations to prove the validity of their findings. But with the derivations in the script, the paper will be rejected. If you still publish it in a physical journal it will not be read by those to whom it is addressed. Dogma 6:Physicists are too ignorant to offer biologists anything useful. Perhaps, some new spectroscopic method or apparatus for force measurement, but that's about it. Leave biology to professionals. Full stop. I make no comments about this extreme point of view, referring the reader to the dispute between Parsegian and Austin, which is still quite relevant today. Next, a pearl of wisdom of a theoretical physicist, Nobel Laureate in Physiology and Medicine, Max Delbrück (Caltech), formulated in his 1949 lecture in Copenhagen, the principles on which organisms of today are based must have been determined by a

  8. Systems biology approaches to heart development and congenital heart disease. (United States)

    Sperling, Silke R


    Even though the foundation of systems biology approaches to cardiac function was led more than fifty years ago, there has been slow progression over the last few decades. Systems biology studies were mainly focused on lower organisms, frequently on yeast. With the boost of high-throughput technologies, systems level analyses, building one backbone of systems biology, started to complement the single-gene focus in the fields of heart development and congenital heart disease. A challenge is to bring together the many uncovered molecular components driving heart development and eventually to establish computational models describing this complex developmental process. Congenital heart diseases represent overlapping phenotypes, reflecting the modularity of heart development. The aetiology of the majority of congenital heart disease is still unknown, and it is suggestive that understanding the biological network underlying heart development will enhance our understanding for its alteration. This review provides an overview of the framework for systems biology approaches focusing on the developing heart and its pathology. Recent methodological developments building the basis for future studies are highlighted and the knowledge gained is specified.

  9. Regenesis how synthetic biology will reinvent nature and ourselves

    CERN Document Server

    Church, George M


    Imagine a future in which human beings have become immune to all viruses, in which bacteria can custom-produce everyday items, like a drinking cup, or generate enough electricity to end oil dependency. Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In "Regenesis," Church and Regis explorethe possibilities--and perils--of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in th...

  10. Cannabinoid Markers in Biological Fluids and Tissues: Revealing Intake. (United States)

    Huestis, Marilyn A; Smith, Michael L


    Understanding cannabis and synthetic cannabinoid intake history is vital for treating drug dependence, investigating cannabinoid effects, and providing information to healthcare personnel, medical examiners, and public health officials; this is particularly relevant today with cannabis medicalization and legalization. Required information includes identifying exposure, time of use, frequency of use, relapse, withdrawal, and predicting cannabinoid effects. Recent controlled cannabinoid administration studies enable the development of models and markers to better identify patterns of intake and exposure. Future challenges include developing behavioral markers of cannabis impairment, bringing to market breathalyzers for cannabinoid detection, and identifying markers of recent cannabis intake in diverse biological matrices. We posit that biological monitoring of cannabinoids and metabolites will improve the characterization of cannabis and synthetic cannabinoid intake history. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Epigenetics and Why Biological Networks are More Controllable than Expected (United States)

    Motter, Adilson


    A fundamental property of networks is that perturbations to one node can affect other nodes, potentially causing the entire system to change behavior or fail. In this talk, I will show that it is possible to exploit this same principle to control network behavior. This approach takes advantage of the nonlinear dynamics inherent to real networks, and allows bringing the system to a desired target state even when this state is not directly accessible or the linear counterpart is not controllable. Applications show that this framework permits both reprogramming a network to a desired task as well as rescuing networks from the brink of failure, which I will illustrate through various biological problems. I will also briefly review the progress our group has made over the past 5 years on related control of complex networks in non-biological domains.

  12. Glial cell biology in the Great Lakes region. (United States)

    Feinstein, Douglas L; Skoff, Robert P


    We report on the tenth bi-annual Great Lakes Glial meeting, held in Traverse City, Michigan, USA, September 27-29 2015. The GLG meeting is a small conference that focuses on current research in glial cell biology. The array of functions that glial cells (astrocytes, microglia, oligodendrocytes, Schwann cells) play in health and disease is constantly increasing. Despite this diversity, GLG meetings bring together scientists with common interests, leading to a better understanding of these cells. This year's meeting included two keynote speakers who presented talks on the regulation of CNS myelination and the consequences of stress on Schwann cell biology. Twenty-two other talks were presented along with two poster sessions. Sessions covered recent findings in the areas of microglial and astrocyte activation; age-dependent changes to glial cells, Schwann cell development and pathology, and the role of stem cells in glioma and neural regeneration.

  13. Stochastic Methods in Biology

    CERN Document Server

    Kallianpur, Gopinath; Hida, Takeyuki


    The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

  14. Biological warfare agents

    Directory of Open Access Journals (Sweden)

    Duraipandian Thavaselvam


    Full Text Available The recent bioterrorist attacks using anthrax spores have emphasized the need to detect and decontaminate critical facilities in the shortest possible time. There has been a remarkable progress in the detection, protection and decontamination of biological warfare agents as many instrumentation platforms and detection methodologies are developed and commissioned. Even then the threat of biological warfare agents and their use in bioterrorist attacks still remain a leading cause of global concern. Furthermore in the past decade there have been threats due to the emerging new diseases and also the re-emergence of old diseases and development of antimicrobial resistance and spread to new geographical regions. The preparedness against these agents need complete knowledge about the disease, better research and training facilities, diagnostic facilities and improved public health system. This review on the biological warfare agents will provide information on the biological warfare agents, their mode of transmission and spread and also the detection systems available to detect them. In addition the current information on the availability of commercially available and developing technologies against biological warfare agents has also been discussed. The risk that arise due to the use of these agents in warfare or bioterrorism related scenario can be mitigated with the availability of improved detection technologies.

  15. Information Complexity and Biology (United States)

    Bagnoli, Franco; Bignone, Franco A.; Cecconi, Fabio; Politi, Antonio

    Kolmogorov contributed directly to Biology in essentially three problems: the analysis of population dynamics (Lotka-Volterra equations), the reaction-diffusion formulation of gene spreading (FKPP equation), and some discussions about Mendel's laws. However, the widely recognized importance of his contribution arises from his work on algorithmic complexity. In fact, the limited direct intervention in Biology reflects the generally slow growth of interest of mathematicians towards biological issues. From the early work of Vito Volterra on species competition, to the slow growth of dynamical systems theory, contributions to the study of matter and the physiology of the nervous system, the first 50-60 years have witnessed important contributions, but as scattered pieces apparently uncorrelated, and in branches often far away from Biology. Up to the 40' it is hard to see the initial loose build up of a convergence, for those theories that will become mainstream research by the end of the century, and connected by the study of biological systems per-se.

  16. Contra biology: a polemic. (United States)

    Dawson, P J


    The philosophical basis of the prevalent biological model of psychiatry is examined critically, with particular reference to the reductionism inherent in such an approach. The pharmacological response initiated by the biological approach is then considered, and the perfidious nature of the complicity between psychiatry and the pharmacological/industrial nexus drawn out. Biological psychiatry is then situated within the prevailing political and economic ideology of the 1990s, and the move towards more community-based psychiatry examined from this perspective. Finally, the stresses necessitated by the incompatibility of many nursing models with the biological paradigm are addressed. This is, as the title suggests, a deliberately polemical and provocative paper, which is offered to stimulate debate both on the future of psychiatric/mental health nursing as a soundly theory-based speciality, and also on the uncritical acceptance of the biological paradigm. Wholesale adoption of this paradigm is considered to be inimical to many of the values notionally espoused by nursing, as well as posing dangers in the larger social field, in terms of the culturally acceptable notions of how we define ourselves, and how such definitions affect our conceptions of freedom, free will and agency.


    Directory of Open Access Journals (Sweden)

    S. R. Bashirov


    Full Text Available With gistostereometry study the structure of the anal canal and anal sphincter dogs in norm and after proctectomy with bringing down the colon, forming neoanus and neosphinkter. The artificial sphincter is the inevitable process of smooth muscle atrophy can save at least half the volume of smooth muscle, similar to the number in the internal sphincter needed to restore function after holding involuntary proctectomy. Neoanus of mucous and submucosal colon relegated acquired typical smooth relief with the advent of the vertical pleats on the type of anal columns of Morgagni and with the perianal skin was closely associated with the subcutaneous portion of the external sphincter smooth muscle and an artificial sphincter. Thus, the experimental model of the internal sphincter and neoanus created by bringing down the mucous and the formation of smooth cuffs, very similar in quantitative and qualitative terms, the structure of the anal canal and anal sphincter dogs and can be used in clinical practice.

  18. Relations between Intuitive Biological Thinking and Biological Misconceptions in Biology Majors and Nonmajors (United States)

    Coley, John D.; Tanner, Kimberly


    Research and theory development in cognitive psychology and science education research remain largely isolated. Biology education researchers have documented persistent scientifically inaccurate ideas, often termed "misconceptions," among biology students across biological domains. In parallel, cognitive and developmental psychologists…

  19. Data Redistribution through MY NASA DATA: Striving to bring authentic NASA data into education (United States)

    Lewis, P. M.; Oostra, D.; Oots, P.; Chambers, L. H.; Moore, S.; Crecelius, S.; Taylor, J.


    The Mentoring and inquirY using NASA Data on Atmospheric and Earth science for Teachers and Amateurs (MY NASA DATA or MND) project was launched in 2004 to bring authentic data into K-12 education. The MND website features a Live Access Server (LAS), an open source tool which allows users to customize data sets to suit their individual needs, choosing from among 200 global Level 3 data sets. Approximately 120 lesson plans that utilize the available parameters are offered to help teachers and students get started with data exploration. Grade appropriate data documentation is also provided (with continual efforts to improve it to better meet the needs of this target audience). Through inquiry and lesson utilization, educators have several connection points to the data. As classrooms shift to problem-based and inquiry learning, the need for a data visualizer/server increases. Through numerous and growing connections to NASA satellite missions, and with access to data as a built-in feature, MND effectively fills this niche to provide a first level of data re-use that is friendly to the K-12 community. Offering a wide variety of data sets allows MND to support many science topics within the K-12 curriculum while extending the use of scientific data from NASA Earth science satellites. Lessons, created by educators across the country, allow MND to connect with the classroom teacher and to meet their data needs. As technology continues to evolve, a second level of data re-use becomes both interesting and possible. Thus, the MND team is now exploring new web and mobile platforms that can be built and distributed on an accelerated time cycle to keep up with information technology developments. With implementation of these new platforms come challenges in promoting new items to the education community, the public, and other potential users. Included in the list of challenges are: ever-evolving technology, prediction of the market, web/mobile platforms, and time-to-market for

  20. Using Fluid Inclusions to Bring Phase Diagrams to Life in a Guided Inquiry Instructional Setting (United States)

    Farver, J. R.; Onasch, C.


    selected sample. Using a fluorite sample (Denton Mine) yields excellent results and a meaningful extension activity. Each student collects Th and Tm data that are then combined and class histograms are generated and interpreted. At this point, a general explanation of fluid inclusions is provided to bring together the student's observations and to assess their understanding. The extension activity involves using the Th, Te, and Tm data obtained for primary inclusions to constrain the true trapping temperature (Tt). The isochore is calculated and plotted on a P-T plot. Using the geothermal gradient for the sample locale, students calculate the hydrostatic and lithostatic gradients for the region and plot these on the P-T diagram in order to constrain the possible range in Tt. Finally, based upon the salinity and Tt range, students determine what ore fluid type is represented (MVT). The evaluation includes observation of participation, answers to questions posed during the engagement activity, and a written report that includes answers to refining and open-ended questions as well as a reflection on their learning. This activity strengthens student's understanding of phase diagrams while introducing them to the importance of fluids in the crust.

  1. Inferring Network Usage from Passive Measurements in ISP Networks: Bringing Visibility of the Network to Internet Operators


    Bermudez Corrales, Ignacio Nicolas


    The Internet is evolving with us along the time, nowadays people are more dependent of it, being used for most of the simple activities of their lives. It is not uncommon use the Internet for voice and video communications, social networking, banking and shopping. Current trends in Internet applications such as Web 2.0, cloud computing, and the internet of things are bound to bring higher traffic volume and more heterogeneous traffic. In addition, privacy concerns and network security traits ...

  2. Biological therapy of psoriasis

    Directory of Open Access Journals (Sweden)

    Sivamani Raja


    Full Text Available The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF-α agents have been associated with a variety of serious and "routine" opportunistic infections.

  3. Biological Soft Robotics. (United States)

    Feinberg, Adam W


    In nature, nanometer-scale molecular motors are used to generate force within cells for diverse processes from transcription and transport to muscle contraction. This adaptability and scalability across wide temporal, spatial, and force regimes have spurred the development of biological soft robotic systems that seek to mimic and extend these capabilities. This review describes how molecular motors are hierarchically organized into larger-scale structures in order to provide a basic understanding of how these systems work in nature and the complexity and functionality we hope to replicate in biological soft robotics. These span the subcellular scale to macroscale, and this article focuses on the integration of biological components with synthetic materials, coupled with bioinspired robotic design. Key examples include nanoscale molecular motor-powered actuators, microscale bacteria-controlled devices, and macroscale muscle-powered robots that grasp, walk, and swim. Finally, the current challenges and future opportunities in the field are addressed.

  4. Epigenetics: Biology's Quantum Mechanics

    Directory of Open Access Journals (Sweden)

    Richard A Jorgensen


    Full Text Available The perspective presented here is that modern genetics is at a similar stage of development as were early formulations of quantum mechanics theory in the 1920's and that in 2010 we are at the dawn of a new revolution in genetics that promises to enrich and deepen our understanding of the gene and the genome. The interrelationships and interdependence of two views of the gene - the molecular biological view and the epigenetic view - are explored, and it is argued that the classical molecular biological view is incomplete without incorporation of the epigenetic perspective and that in a sense the molecular biological view has been evolving to include the epigenetic view. Intriguingly, this evolution of the molecular view toward the broader and more inclusive epigenetic view of the gene has an intriguing, if not precise, parallel in the evolution of concepts of atomic physics from Newtonian mechanics to quantum mechanics that are interesting to consider.

  5. Topics in mathematical biology

    CERN Document Server

    Hadeler, Karl Peter


    This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

  6. Traceability of biologicals

    DEFF Research Database (Denmark)

    Vermeer, Niels S; Spierings, Irina; Mantel-Teeuwisse, Aukje K


    INTRODUCTION: Traceability is important in the postmarketing surveillance of biologicals, since changes in the manufacturing process may give rise to product- or batch-specific risks. With the expected expansion of the biosimilar market, there have been concerns about the ability to trace...... individual products within pharmacovigilance databases. AREAS COVERED: The authors discuss the present challenges in the traceability of biologicals in relation to pharmacovigilance, by exploring the processes involved in ensuring traceability. They explore both the existing systems that are in place...... for the recording of exposure information in clinical practice, as well as the critical steps involved in the transfer of exposure data to various pharmacovigilance databases. EXPERT OPINION: The existing systems ensure the traceability of biologicals down to the manufacturer within pharmacy records, but do...

  7. Wireless Biological Electronic Sensors. (United States)

    Cui, Yue


    The development of wireless biological electronic sensors could open up significant advances for both fundamental studies and practical applications in a variety of areas, including medical diagnosis, environmental monitoring, and defense applications. One of the major challenges in the development of wireless bioelectronic sensors is the successful integration of biosensing units and wireless signal transducers. In recent years, there are a few types of wireless communication systems that have been integrated with biosensing systems to construct wireless bioelectronic sensors. To successfully construct wireless biological electronic sensors, there are several interesting questions: What types of biosensing transducers can be used in wireless bioelectronic sensors? What types of wireless systems can be integrated with biosensing transducers to construct wireless bioelectronic sensors? How are the electrical sensing signals generated and transmitted? This review will highlight the early attempts to address these questions in the development of wireless biological electronic sensors.

  8. Informing biological design by integration of systems and synthetic biology. (United States)

    Smolke, Christina D; Silver, Pamela A


    Synthetic biology aims to make the engineering of biology faster and more predictable. In contrast, systems biology focuses on the interaction of myriad components and how these give rise to the dynamic and complex behavior of biological systems. Here, we examine the synergies between these two fields. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. The feasibility of using 'bring your own device' (BYOD) technology for electronic data capture in multicentre medical audit and research. (United States)

    Faulds, M C; Bauchmuller, K; Miller, D; Rosser, J H; Shuker, K; Wrench, I; Wilson, P; Mills, G H


    Large-scale audit and research projects demand robust, efficient systems for accurate data collection, handling and analysis. We utilised a multiplatform 'bring your own device' (BYOD) electronic data collection app to capture observational audit data on theatre efficiency across seven hospital Trusts in South Yorkshire in June-August 2013. None of the participating hospitals had a dedicated information governance policy for bring your own device. Data were collected by 17 investigators for 392 individual theatre lists, capturing 14,148 individual data points, 12, 852 (91%) of which were transmitted to a central database on the day of collection without any loss of data. BYOD technology enabled accurate collection of a large volume of secure data across multiple NHS organisations over a short period of time. Bring your own device technology provides a method for collecting real-time audit, research and quality improvement data within healthcare systems without compromising patient data protection. © 2015 The Association of Anaesthetists of Great Britain and Ireland.

  10. What Change Can The New Developments In Energy Sector Bring Into the World`s Energypolitical and Geopolitical Order?

    Directory of Open Access Journals (Sweden)



    Full Text Available The recent developments bring US to a leading natural gas and oil producer position. The attempts in last 20 years to bring new horizontal drilling and hydraulic fracturing technologies together have developed a success in shale gas and oil production in US; the production volumes has reached to a position to redefine the market. Last estimations are bringing more information about the shale capacities of the major basins of the world. However, the estimates are based on a wide range of assumptions and consequently their results vary in a large scale. In any case, these developments have crucial economic, political and geopolitical consequences on the energy market, petroleum producer and consumer countries and regions. Despite the wide range of ambiguity of the estimated size of the resources, the estimations show US and North America has one of the biggest potential, already turning technology into the giant production numbers. Some of the estimations allege so big numbers can even mean to a new world order. The asymmetric nature of the potential, can also be said, increases some of the expected impacts too. In this study, basically, we want to supply an initial solid and economical evaluation to this ambiguity. We are trying to shape a frame for the new energy potential and to put it in a place in the current practice of the world. Secondly, in this context, we are underlying here some of the possible economic and geopolitical consequences each of which can constitute a subject of deeper study.

  11. Neutron structural biology

    Energy Technology Data Exchange (ETDEWEB)

    Niimura, Nobuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment


    Neutron structural biology will be one of the most important fields in the life sciences which will interest human beings in the 21st century because neutrons can provide not only the position of hydrogen atoms in biological macromolecules but also the dynamic molecular motion of hydrogen atoms and water molecules. However, there are only a few examples experimentally determined at present because of the lack of neutron source intensity. Next generation neutron source scheduled in JAERI (Performance of which is 100 times better than that of JRR-3M) opens the life science of the 21st century. (author)

  12. The Biological Universe (United States)

    Dick, Steven J.


    Introduction; 1. From the physical world to the biological universe: Democritus to Lowell; 2. Plurality of worlds and the decline of anthropocentrism; 3. The solar system: the limits of observation; 4. Solar systems beyond: the limits of theory; 5. Extraterrestrials in literature and the arts: the role of imagination; 6. The UFO controversy: on perception and deception; 7. The origin and evolution of life in the extraterrestrial context; 8. SETI: the Search for Extraterrestrial Intelligence; 9. The convergence of disciplines: birth of a new science; 10. The meaning of life; Summary and conclusion: the biological universe and the limits of science.

  13. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Galitski, Timothy P.


    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  14. Bringing Global Climate Change Education to Alabama Middle School and High School Classrooms (United States)

    Lee, M.; Mitra, C.; Percival, E.; Thomas, A.; Lucy, T.; Hickman, E.; Cox, J.; Chaudhury, S. R.; Rodger, C.


    A NASA-funded Innovations in Climate Education (NICE) Program has been launched in Alabama to improve high school and middle school education in climate change science. The overarching goal is to generate a better informed public that understands the consequences of climate change and can contribute to sound decision making on related issues. Inquiry based NICE modules have been incorporated into the existing course of study for 9-12 grade biology, chemistry, and physics classes. In addition, new modules in three major content areas (earth and space science, physical science, and biological science) have been introduced to selected 6-8 grade science teachers in the summer of 2013. The NICE modules employ five E's of the learning cycle: Engage, Explore, Explain, Extend and Evaluate. Modules learning activities include field data collection, laboratory measurements, and data visualization and interpretation. Teachers are trained in the use of these modules for their classroom through unique partnership with Alabama Science in Motion (ASIM) and the Alabama Math Science Technology Initiative (AMSTI). Certified AMSTI teachers attend summer professional development workshops taught by ASIM and AMSTI specialists to learn to use NICE modules. During the school year, the specialists in turn deliver the needed equipment to conduct NICE classroom exercises and serve as an in-classroom resource for teachers and their students. Scientists are partnered with learning and teaching specialists and lead teachers to implement and test efficacy of instructional materials, models, and NASA data used in classroom. The assessment by professional evaluators after the development of the modules and the training of teachers indicates that the modules are complete, clear, and user-friendly. The overall teacher satisfaction from the teacher training was 4.88/5.00. After completing the module teacher training, the teachers reported a strong agreement that the content developed in the NICE

  15. Molecular Biology for the Environment: an EC-US hands-on Course in Environmental Biotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Victor de Lorenzo; Juan Luis Ramos; Jerome Kukor; Gerben J. Zylstra


    One of the central goals of this activity is to bring together young scientists (at the late Ph.D. or early postdoctoral stages of their careers) in a forum that should result in future collaborations. The course is designed to give scientists hands-on experience in modern, up-to-date biotechnological methods at the interface between molecular biology and environmental biotechnology for the analysis of microorganisms and their activities with regard to the remediation of pollutants in the environment.

  16. 28 CFR 0.64-5 - Policy with regard to bringing charges under the Economic Espionage Act of 1996, Pub. L. 104-294... (United States)


    ... Division § 0.64-5 Policy with regard to bringing charges under the Economic Espionage Act of 1996, Pub. L... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Policy with regard to bringing charges under the Economic Espionage Act of 1996, Pub. L. 104-294, effective October 11, 1996. 0.64-5 Section 0...

  17. Bringing functions together with fusion enzymes--from nature's inventions to biotechnological applications. (United States)

    Elleuche, Skander


    It is a mammoth task to develop a modular protein toolbox enabling the production of posttranslational organized multifunctional enzymes that catalyze reactions in complex pathways. However, nature has always guided scientists to mimic evolutionary inventions in the laboratory and, nowadays, versatile methods have been established to experimentally connect enzymatic activities with multiple advantages. Among the oldest known natural examples is the linkage of two or more juxtaposed proteins catalyzing consecutive, non-consecutive, or opposing reactions by a native peptide bond. There are multiple reasons for the artificial construction of such fusion enzymes including improved catalytic activities, enabled substrate channelling by proximity of biocatalysts, higher stabilities, and cheaper production processes. To produce fused proteins, it is either possible to genetically fuse coding open reading frames or to connect proteins in a posttranslational process. Molecular biology techniques that have been established for the production of end-to-end or insertional fusions include overlap extension polymerase chain reaction, cloning, and recombination approaches. Depending on their flexibility and applicability, these methods offer various advantages to produce fusion genes in high throughput, different orientations, and including linker sequences to maximize the flexibility and performance of fusion partners. In this review, practical techniques to fuse genes are highlighted, enzymatic parameters to choose adequate enzymes for fusion approaches are summarized, and examples with biotechnological relevance are presented including a focus on plant biomass-degrading glycosyl hydrolases.

  18. Current Trends in Biology Education. (United States)

    Wivagg, Daniel E.; Moore, Randy


    This newsletter reports on the status of biology education in the United States. It states that biology has entered its "golden age" because of the emergence of biotechnology, ecology, agricultural productivity, and human biology as major societal issues. This report discusses the status of the informal national curriculum of biology, involving…

  19. Systems biology in animal sciences

    NARCIS (Netherlands)

    Woelders, H.; Pas, te M.F.W.; Bannink, A.; Veerkamp, R.F.; Smits, M.A.


    Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes

  20. Biological science in conservation (United States)

    David M. Johns


    Large-scale wildlands reserve systems offer one of the best hopes for slowing, if not reversing, the loss of biodiversity and wilderness. Establishing such reserves requires both sound biology and effective advocacy. Attempts by The Wildlands Project and its cooperators to meld science and advocacy in the service of conservation is working, but is not without some...

  1. Evolution, Entropy, & Biological Information (United States)

    Peterson, Jacob


    A logical question to be expected from students: "How could life develop, that is, change, evolve from simple, primitive organisms into the complex forms existing today, while at the same time there is a generally observed decline and disorganization--the second law of thermodynamics?" The explanations in biology textbooks relied upon by…

  2. Biological system interactions. (United States)

    Adomian, G; Adomian, G E; Bellman, R E


    Mathematical modeling of cellular population growth, interconnected subsystems of the body, blood flow, and numerous other complex biological systems problems involves nonlinearities and generally randomness as well. Such problems have been dealt with by mathematical methods often changing the actual model to make it tractable. The method presented in this paper (and referenced works) allows much more physically realistic solutions.

  3. Biological response modifiers

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.


    Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

  4. Systems biology and medicine

    Indian Academy of Sciences (India)

    Immunology Group, International Centre for Genetic Engineering and Biotechnology,. Aruna Asaf ... simple laws. As a result, the most obvious strat- egy for understanding complex natural systems in general was to reduce the system into smaller, sim- pler, and .... networked organization of biological system would emerge ...

  5. Entropy in Biology

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 9. Entropy in Biology. Jayant B Udgaonkar. General Article Volume 6 Issue 9 September 2001 pp 61-66. Fulltext. Click here to view fulltext PDF. Permanent link: Author Affiliations.

  6. Tree biology and dendrochemistry (United States)

    Kevin T. Smith; Walter C. Shortle


    Dendrochemistry, the interpretation of elemental analysis of dated tree rings, can provide a temporal record of environmental change. Using the dendrochemical record requires an understanding of tree biology. In this review, we pose four questions concerning assumptions that underlie recent dendrochemical research: 1) Does the chemical composition of the wood directly...

  7. Cryptochromes and Biological Clocks

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 9. Cryptochromes and Biological Clocks. V R Bhagwat. General Article Volume 7 Issue 9 September 2002 pp 36-48. Fulltext. Click here to view fulltext PDF. Permanent link: Keywords.

  8. Evolutionary Biology Today

    Indian Academy of Sciences (India)

    Amitabh Joshi studies and teaches evolutionary ' genetics and population ecology at the Jawaharlal. Nehru Centre for Advanced. Scientific Research,. Bangalore. His current research interests are in life- history, evolution, the evolutionary genetics of biological clocks, the evolution of ecological specialization dynamics. He.

  9. Antiprotons get biological

    CERN Multimedia


    After its final run in September, the first results of the Antiproton Cell Experiment (ACE) look very promising. It was the first experiment to take data on the biological effects of antiproton beams to evaluate the potential of antiprotons in radiation therapy.

  10. Biologically inspired intelligent robots (United States)

    Bar-Cohen, Yoseph; Breazeal, Cynthia


    Humans throughout history have always sought to mimic the appearance, mobility, functionality, intelligent operation, and thinking process of biological creatures. This field of biologically inspired technology, having the moniker biomimetics, has evolved from making static copies of human and animals in the form of statues to the emergence of robots that operate with realistic behavior. Imagine a person walking towards you where suddenly you notice something weird about him--he is not real but rather he is a robot. Your reaction would probably be "I can't believe it but this robot looks very real" just as you would react to an artificial flower that is a good imitation. You may even proceed and touch the robot to check if your assessment is correct but, as oppose to the flower case, the robot may be programmed to respond physical and verbally. This science fiction scenario could become a reality as the current trend continues in developing biologically inspired technologies. Technology evolution led to such fields as artificial muscles, artificial intelligence, and artificial vision as well as biomimetic capabilities in materials science, mechanics, electronics, computing science, information technology and many others. This paper will review the state of the art and challenges to biologically-inspired technologies and the role that EAP is expected to play as the technology evolves.

  11. The Biology of Food (United States)

    Bonner, J. Jose


    In this article, the author discusses "The Biology of Food" course. This course--a large lecture course with no laboratory section--is a mixture of kitchen chemistry, post-eating food metabolism, origins of different foods (from crop breeding to evolution), and ecological and environmental impacts of farming and harvesting practices. Nearly every…

  12. Evolutionary Biology Today

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 2. Evolutionary Biology Today - What do Evolutionary Biologists do? Amitabh Joshi. Series Article Volume 8 Issue 2 February 2003 pp 6-18. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Biophysics and systems biology. (United States)

    Noble, Denis


    Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded rapidly during the first decade of the twenty-first century and, through its contribution to what is now called systems biology, it is set to revise many of the fundamental principles of biology, including the relations between genotypes and phenotypes. Evolutionary theory, in particular, will require re-assessment. To succeed in this, computational and systems biology will need to develop the theoretical framework required to deal with multilevel interactions. While computational power is necessary, and is forthcoming, it is not sufficient. We will also require mathematical insight, perhaps of a nature we have not yet identified. This article is therefore also a challenge to mathematicians to develop such insights.

  14. Systems biology at work

    NARCIS (Netherlands)

    Martins Dos Santos, V.A.P.; Damborsky, J.


    In his editorial overview for the 2008 Special Issue on this topic, the late Jaroslav Stark pointedly noted that systems biology is no longer a niche pursuit, but a recognized discipline in its own right “noisily” coming of age [1]. Whilst general underlying principles and basic techniques are now

  15. Biological scaling and physics

    Indian Academy of Sciences (India)


    Kleiber scaling in the previous paragraph has the growth in Q kept smaller in spite of the high power dependence on R in eq. (1). 4. Conclusions. The arguments that have been advanced so far by pre- vious authors swing to extremes at either end. Thus, the rich variety and diversity in biology, including of scaling exponents ...

  16. Bayes in biological anthropology. (United States)

    Konigsberg, Lyle W; Frankenberg, Susan R


    In this article, we both contend and illustrate that biological anthropologists, particularly in the Americas, often think like Bayesians but act like frequentists when it comes to analyzing a wide variety of data. In other words, while our research goals and perspectives are rooted in probabilistic thinking and rest on prior knowledge, we often proceed to use statistical hypothesis tests and confidence interval methods unrelated (or tenuously related) to the research questions of interest. We advocate for applying Bayesian analyses to a number of different bioanthropological questions, especially since many of the programming and computational challenges to doing so have been overcome in the past two decades. To facilitate such applications, this article explains Bayesian principles and concepts, and provides concrete examples of Bayesian computer simulations and statistics that address questions relevant to biological anthropology, focusing particularly on bioarchaeology and forensic anthropology. It also simultaneously reviews the use of Bayesian methods and inference within the discipline to date. This article is intended to act as primer to Bayesian methods and inference in biological anthropology, explaining the relationships of various methods to likelihoods or probabilities and to classical statistical models. Our contention is not that traditional frequentist statistics should be rejected outright, but that there are many situations where biological anthropology is better served by taking a Bayesian approach. To this end it is hoped that the examples provided in this article will assist researchers in choosing from among the broad array of statistical methods currently available. Copyright © 2013 Wiley Periodicals, Inc.

  17. Coordination Compounds in Biology

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 4; Issue 6. Coordination Compounds in Biology - The Chemistry of Vitamin B12 and Model Compounds. K Hussian Reddy. General Article Volume 4 Issue 6 June 1999 pp 67-77 ...

  18. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Goncalo Espregueira Cruz


    we present an overview of the current sequencing technologies and the methods used in typical high-throughput data analysis pipelines. Subsequently, we contextualize high-throughput DNA sequencing technologies within their applications in non-model organism biology. We include tips regarding managing...

  19. Situeret interesse i biologi

    DEFF Research Database (Denmark)

    Dohn, Niels Bonderup


    Interesse hævdes at spille en vigtig rolle i læring. Med udgangspunkt i interesseteori og situeret læring har jeg foretaget et studium i en gymnasieklasse med biologi på højt niveau, med henblik på at identificere hvilke forhold der har betydning for hvad der fanger elevers interesse. Jeg har...

  20. Doublethink in Biological Education (United States)

    Cox, Donald D.


    Presents the material given in a talk at the 1974 convention of the National Science Teachers Association in which the author compares practices in biology education to George Orwell's concept of "doublethink," i.e., the ability to hold two contradictory beliefs in one's mind simultaneously and to accept both of them. Developments in curriculum…

  1. Plant Systems Biology (editorial) (United States)

    In June 2003, Plant Physiology published an Arabidopsis special issue devoted to plant systems biology. The intention of Natasha Raikhel and Gloria Coruzzi, the two editors of this first-of-its-kind issue, was ‘‘to help nucleate this new effort within the plant community’’ as they considered that ‘‘...

  2. Biological trade and markets. (United States)

    Hammerstein, Peter; Noë, Ronald


    Cooperation between organisms can often be understood, like trade between merchants, as a mutually beneficial exchange of services, resources or other 'commodities'. Mutual benefits alone, however, are not sufficient to explain the evolution of trade-based cooperation. First, organisms may reject a particular trade if another partner offers a better deal. Second, while human trade often entails binding contracts, non-human trade requires unwritten 'terms of contract' that 'self-stabilize' trade and prevent cheating even if all traders strive to maximize fitness. Whenever trading partners can be chosen, market-like situations arise in nature that biologists studying cooperation need to account for. The mere possibility of exerting partner choice stabilizes many forms of otherwise cheatable trade, induces competition, facilitates the evolution of specialization and often leads to intricate forms of cooperation. We discuss selected examples to illustrate these general points and review basic conceptual approaches that are important in the theory of biological trade and markets. Comparing these approaches with theory in economics, it turns out that conventional models-often called 'Walrasian' markets-are of limited relevance to biology. In contrast, early approaches to trade and markets, as found in the works of Ricardo and Cournot, contain elements of thought that have inspired useful models in biology. For example, the concept of comparative advantage has biological applications in trade, signalling and ecological competition. We also see convergence between post-Walrasian economics and biological markets. For example, both economists and biologists are studying 'principal-agent' problems with principals offering jobs to agents without being sure that the agents will do a proper job. Finally, we show that mating markets have many peculiarities not shared with conventional economic markets. Ideas from economics are useful for biologists studying cooperation but need


    Directory of Open Access Journals (Sweden)

    M. K. Guseynov


    Full Text Available Aim. We present the data on the biological resources of the Caspian Sea, based on the analysis of numerous scientific sources published between years of 1965 and 2011. Due to changes in various biotic and abiotic factors we find it important to discuss the state of the major groups of aquatic biocenosis including algae, crayfish, shrimp, pontogammarus, fish and Caspian seal. Methods. Long-term data has been analyzed on the biology and ecology of the main commercial fish stocks and their projected catches for qualitative and quantitative composition, abundance and biomass of aquatic organisms that make up the food base for fish. Results and discussion. It has been found that the widespread commercial invertebrates in the Caspian Sea are still poorly studied; their stocks are not identified and not used commercially. There is a great concern about the current state of the main commercial fish stocks of the Caspian Sea. A critical challenge is to preserve the pool of biological resources and the restoration of commercial stocks of Caspian fish. For more information about the state of the marine ecosystem in modern conditions, expedition on Caspian Sea should be carried out to study the hydrochemical regime and fish stocks, assessment of sturgeon stocks, as well as the need to conduct sonar survey for sprat stocks. Conclusions. The main condition for preserving the ecosystem of the Caspian Sea and its unique biological resources is to develop and apply environmentally-friendly methods of oil, issuing concerted common fisheries rules in various regions of theCaspian Sea, strengthening of control for sturgeon by all Caspian littoral states. The basic principle of the protection of biological resources is their rational use, based on the preservation of optimal conditions of their natural or artificial reproduction. 

  4. Bringing metabolic networks to life: convenience rate law and thermodynamic constraints

    Directory of Open Access Journals (Sweden)

    Klipp Edda


    Full Text Available Abstract Background Translating a known metabolic network into a dynamic model requires rate laws for all chemical reactions. The mathematical expressions depend on the underlying enzymatic mechanism; they can become quite involved and may contain a large number of parameters. Rate laws and enzyme parameters are still unknown for most enzymes. Results We introduce a simple and general rate law called "convenience kinetics". It can be derived from a simple random-order enzyme mechanism. Thermodynamic laws can impose dependencies on the kinetic parameters. Hence, to facilitate model fitting and parameter optimisation for large networks, we introduce thermodynamically independent system parameters: their values can be varied independently, without violating thermodynamical constraints. We achieve this by expressing the equilibrium constants either by Gibbs free energies of formation or by a set of independent equilibrium constants. The remaining system parameters are mean turnover rates, generalised Michaelis-Menten constants, and constants for inhibition and activation. All parameters correspond to molecular energies, for instance, binding energies between reactants and enzyme. Conclusion Convenience kinetics can be used to translate a biochemical network – manually or automatically - into a dynamical model with plausible biological properties. It implements enzyme saturation and regulation by activators and inhibitors, covers all possible reaction stoichiometries, and can be specified by a small number of parameters. Its mathematical form makes it especially suitable for parameter estimation and optimisation. Parameter estimates can be easily computed from a least-squares fit to Michaelis-Menten values, turnover rates, equilibrium constants, and other quantities that are routinely measured in enzyme assays and stored in kinetic databases.


    Directory of Open Access Journals (Sweden)

    T. M. Azevedo


    Full Text Available Accidents involving biological material can cause diseases to the professional healthcare and also bring psychosocial effects. The aim of this study was to characterize the accidents occurring with biological material with professional of clinical laboratories of Sinop-MT. Data were collected by a questionnaire consisting of sociodemographic and health variables. 21 (87.5% of respondents stated that they never suffered any kind of accident. One of the injured workers reported that there was involvement in your emotional life. It is observed underreporting of occupational accidents by employees affected, making it difficult to increase research on the subject and actions about the problem.

  6. Systems biology in animal sciences. (United States)

    Woelders, H; Te Pas, M F W; Bannink, A; Veerkamp, R F; Smits, M A


    Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract understanding from these data of biological processes and animal traits are not yet frequently used. This paper aims to explain what systems biology is and which areas of animal sciences could benefit from systems biology approaches. Systems biology aims to understand whole biological systems working as a unit, rather than investigating their individual components. Therefore, systems biology can be considered a holistic approach, as opposed to reductionism. The recently developed 'omics' technologies enable biological sciences to characterize the molecular components of life with ever increasing speed, yielding vast amounts of data. However, biological functions do not follow from the simple addition of the properties of system components, but rather arise from the dynamic interactions of these components. Systems biology combines statistics, bioinformatics and mathematical modeling to integrate and analyze large amounts of data in order to extract a better understanding of the biology from these huge data sets and to predict the behavior of biological systems. A 'system' approach and mathematical modeling in biological sciences are not new in itself, as they were used in biochemistry, physiology and genetics long before the name systems biology was coined. However, the present combination of mass biological data and of computational and modeling tools is unprecedented and truly represents a major paradigm shift in biology. Significant advances have been made using systems biology approaches, especially in the field of bacterial and eukaryotic cells and in human medicine. Similarly, progress is being made with 'system approaches' in animal sciences, providing exciting opportunities to predict and modulate animal traits.

  7. [Systems biology applications to explore secondary metabolites in medicinal plants]. (United States)

    Huang, Luqi; Gao, Wei; Zhou, Jie; Wang, Ruiting


    Secondary metabolites are produced during the growth and development of plants along with the adaptation of outer environment, as a rule they are the main active ingredients in medicinal plants and ensure the quality of crude drugs. Since biogenesis is quite complex, the production and accumulation of secondary metabolites are influenced by various biotic and abiotic factors either from gene or environments, the complexity may affect quality control of crude drugs and utilization of the active ingredients. The thought and approach adopted in systems biology is a powerful tool to explore biology fully, along with the development of modern molecular biology and information biology, omics integration like genomics, transcriptomics, proteomics, and metabolomics will bring new opportunities for the study of secondary metabolites of medicinal plant. It has great significance to apply this holistic and systematic method in researches on biosynthetic pathway, signal transduction, ecological environment and metabolic engineering of the formation of the secondary metabolites of medicinal plants, and in building secondary metabolite biosynthesis gene expression and regulation system model, in order to explain the origin of the active ingredients of medicinal plants, formation mechanism of the Chinese herbs, metabolic engineering effecting active ingredients of medicinal plants, and the rational exploitation and utilization of resources of medicinal plants systematically.

  8. Question answering for biology. (United States)

    Neves, Mariana; Leser, Ulf


    Biologists often pose queries to search engines and biological databases to obtain answers related to ongoing experiments. This is known to be a time consuming, and sometimes frustrating, task in which more than one query is posed and many databases are consulted to come to possible answers for a single fact. Question answering comes as an alternative to this process by allowing queries to be posed as questions, by integrating various resources of different nature and by returning an exact answer to the user. We have surveyed the current solutions on question answering for Biology, present an overview on the methods which are usually employed and give insights on how to boost performance of systems in this domain. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Quantum physics meets biology. (United States)

    Arndt, Markus; Juffmann, Thomas; Vedral, Vlatko


    Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the past decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world-view of quantum coherences, entanglement, and other nonclassical effects, has been heading toward systems of increasing complexity. The present perspective article shall serve as a "pedestrian guide" to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future "quantum biology," its current status, recent experimental progress, and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.

  10. [Cell biology and cosmetology]. (United States)

    Traniello, S; Cavalletti, T


    Cellular biology can become the natural support of research in the field of cosmetics because it is able to provide alternative experimental models which can partially replace the massive use of laboratory animals. Cultures of human skin cells could be used in tests investigating irritation of the skin. We have developed an "in vitro" experimental model that allows to evaluate the damage caused by the free radicals to the fibroblasts in culture and to test the protective action of the lipoaminoacids. Experimenting on human cell cultures presents the advantage of eliminating the extrapolation between the different species, of allowing a determination of the biological action of a substance and of evaluating its dose/response effect. This does not mean that "in vitro" experimenting could completely replace experimenting on living animals, but the "in vitro" model can be introduced in the realisation of preliminary screenings.

  11. Topology in Molecular Biology

    CERN Document Server

    Monastyrsky, Michail Ilych


    The book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form.

  12. Melanins are Biological Diamonds

    Directory of Open Access Journals (Sweden)

    L. Venger


    Full Text Available In the article the physical, chemical, biological properties, the significance and the role in Nature of melanin pigments are considered. Very long time these pigments were considered as metabolism garbage in the living organisms. The comparison of the only same results and facts from the huge masses of the science information with main principles of the new science paradigm – the Theory of Torsion Fields and the Theory of Physical Vacuum – allow to change the view on the true invention, the biological role and the functions of Melanins in Nature. Many theoretical and experimental facts specify on the active participation of melanins in the energyand-informative processes and their first degree role on the all evolution stages of living organisms: from the chemical evolution to the brain and consciousness functions. In the sense Melanins are the most precious substance for the living organisms, true their Diamonds.

  13. Cloning humans? Biological, ethical, and social considerations. (United States)

    Ayala, Francisco J


    There are, in mankind, two kinds of heredity: biological and cultural. Cultural inheritance makes possible for humans what no other organism can accomplish: the cumulative transmission of experience from generation to generation. In turn, cultural inheritance leads to cultural evolution, the prevailing mode of human adaptation. For the last few millennia, humans have been adapting the environments to their genes more often than their genes to the environments. Nevertheless, natural selection persists in modern humans, both as differential mortality and as differential fertility, although its intensity may decrease in the future. More than 2,000 human diseases and abnormalities have a genetic causation. Health care and the increasing feasibility of genetic therapy will, although slowly, augment the future incidence of hereditary ailments. Germ-line gene therapy could halt this increase, but at present, it is not technically feasible. The proposal to enhance the human genetic endowment by genetic cloning of eminent individuals is not warranted. Genomes can be cloned; individuals cannot. In the future, therapeutic cloning will bring enhanced possibilities for organ transplantation, nerve cells and tissue healing, and other health benefits.

  14. Nutritional systems biology: definitions and approaches. (United States)

    Panagiotou, Gianni; Nielsen, Jens


    Nutrigenetics and nutrigenomics are nascent areas that are evolving quickly and riding on the wave of "personalized medicine" that is providing opportunities in the discovery and development of nutraceutical compounds. The human genome sequence and sequences of model organisms provide the equivalent of comprehensive blueprints and parts lists that describe dynamic networks and the bases for understanding their responses to external and internal perturbations. Unfolding the interrelationships among genes, gene products, and dietary habits is fundamental for identifying individuals who will benefit most from, or be placed at risk by, intervention strategies. More accurate assessment of the inputs to human health and the consequences of those inputs measured as accurate transcriptomic, proteomic, and metabolomic analyses would bring personalized health/diet to practice far faster than would waiting for a predictive knowledge of genetic variation. It is widely recognized that systems and network biology has the potential to increase our understanding of how nutrition influences metabolic pathways and homeostasis, how this regulation is disturbed in a diet-related disease, and to what extent individual genotypes contribute to such diseases.

  15. Biological significance of selenium

    Energy Technology Data Exchange (ETDEWEB)

    Duerre, P.; Andreesen, J.R.


    Until a few years ago, selenium was exclusively thought of as a toxic substance which was applied mainly in the optical and electrical industries. By now, many biological reactions have been detected which cannot take place without the catalytic effect of selenium. The majority of these processes was found and clarified in microorganisms; however, the anticarcinogenic properties of this trace element may well have some significance for man in future.

  16. Dominating biological networks.

    Directory of Open Access Journals (Sweden)

    Tijana Milenković

    Full Text Available Proteins are essential macromolecules of life that carry out most cellular processes. Since proteins aggregate to perform function, and since protein-protein interaction (PPI networks model these aggregations, one would expect to uncover new biology from PPI network topology. Hence, using PPI networks to predict protein function and role of protein pathways in disease has received attention. A debate remains open about whether network properties of "biologically central (BC" genes (i.e., their protein products, such as those involved in aging, cancer, infectious diseases, or signaling and drug-targeted pathways, exhibit some topological centrality compared to the rest of the proteins in the human PPI network.To help resolve this debate, we design new network-based approaches and apply them to get new insight into biological function and disease. We hypothesize that BC genes have a topologically central (TC role in the human PPI network. We propose two different concepts of topological centrality. We design a new centrality measure to capture complex wirings of proteins in the network that identifies as TC those proteins that reside in dense extended network neighborhoods. Also, we use the notion of domination and find dominating sets (DSs in the PPI network, i.e., sets of proteins such that every protein is either in the DS or is a neighbor of the DS. Clearly, a DS has a TC role, as it enables efficient communication between different network parts. We find statistically significant enrichment in BC genes of TC nodes and outperform the existing methods indicating that genes involved in key biological processes occupy topologically complex and dense regions of the network and correspond to its "spine" that connects all other network parts and can thus pass cellular signals efficiently throughout the network. To our knowledge, this is the first study that explores domination in the context of PPI networks.

  17. Plankton Production Biology (United States)


    had largely completed our analysis of the historic O2 data, we learned of the introduction to the field of the STOX sensor (Switchable Trace amount...population dynamics (growth rate, production, mortality) of copepod nauplii in the field or captured water columns (mesocosms). Since biology...Methods, 7, 371-381, 2009. 4 Sazhina, L.I. Keys to the Nauplii of 86 Common Marine Pelagic Copepods [new English title] Kiev: Naukova Dumka, 238

  18. Types of biological variables. (United States)

    Mayya, Shreemathi S; Monteiro, Ashma D; Ganapathy, Sachit


    Identification and description of variables used in any study is a necessary component in biomedical research. Statistical analyses rely on the type of variables that are involved in the study. In this short article, we introduce the different types of biological variables. A researcher has to be familiar with the type of variable he/she is dealing with in his/her research to decide about appropriate graphs/diagrams, summary measures and statistical analysis.

  19. Menstrual Cycle: Basic Biology


    Hawkins, Shannon M.; Matzuk, Martin M.


    The basic biology of the menstrual cycle is a complex, coordinated sequence of events involving the hypothalamus, anterior pituitary, ovary, and endometrium. The menstrual cycle with all its complexities can be easily perturbed by environmental factors such as stress, extreme exercise, eating disorders, and obesity. Furthermore, genetic influences such as fragile X premutations (Chapter X), X chromosome abnormalities (Chapter X), and galactose-1-phosphate uridyltransferase (GALT) point mutati...

  20. Biological Correlates of Empathy

    Directory of Open Access Journals (Sweden)

    E. Timucin Oral


    Full Text Available Empathy can be defined as the capacity to know emotionally what another is experiencing from within the frame of reference of that other person and the capacity to sample the feelings of another or it can be metaphorized as to put oneself in another’s shoes. Although the concept of empathy was firstly described in psychological theories, researches studying the biological correlates of psychological theories have been increasing recently. Not suprisingly, dinamically oriented psychotherapists Freud, Kohut, Basch and Fenichel had suggested theories about the biological correlates of empathy concept and established the basis of this modality decades ago. Some other theorists emphasized the importance of empathy in the early years of lifetime regarding mother-child attachment in terms of developmental psychology and investigated its role in explanation of psychopathology. The data coming from some of the recent brain imaging and animal model studies also seem to support these theories. Although increased activity in different brain regions was shown in many of the brain imaging studies, the role of cingulate cortex for understanding mother-child relationship was constantly emphasized in nearly all of the studies. In addition to these studies, a group of Italian scientists has defined a group of neurons as “mirror neurons” in their studies observing rhesus macaque monkeys. Later, they also defined mirror neurons in human studies, and suggested them as “empathy neurons”. After the discovery of mirror neurons, the hopes of finding the missing part of the puzzle for understanding the biological correlates of empathy raised again. Although the roles of different biological parameters such as skin conductance and pupil diameter for defining empathy have not been certain yet, they are going to give us the opportunity to revise the inconsistent basis of structural validity in psychiatry and to stabilize descriptive validity. In this review, the