WorldWideScience

Sample records for brusselaers stam monstrey

  1. NIMS and Empa announce STAM collaboration

    Science.gov (United States)

    Yoshida, Toyonobu; Krug, Harald F.

    2014-02-01

    In January 2014, the Swiss Federal Laboratories for Materials Science and Technology (Empa) joined the National Institute for Materials Science (NIMS) in collaborative activities on Science and Technology of Advanced Materials (STAM). STAM was founded in 2000. In 2005 NIMS took over the management of its peer review and financial systems, resulting in a continuous rise of the impact of the journal. Empa will provide further support for the editorial management of STAM. In particular, it will establish a European office in Switzerland and reinforce the Editorial Board. From this point of view, I am pleased and excited to have new colleagues from Empa on our Editorial Board, and I believe that this collaboration will bring us a remarkable improvement in the international visibility of STAM and increase the number of paper submissions from Europe. It will expand the topics covered in the journal from traditional fields of materials science with a focus on energy and environmental issues to medical and bioengineering applications, where Empa has a significant expertise. I firmly believe that Empa's participation in publishing STAM will reinforce its position as an open-access journal with a global audience. Together with my colleagues, Yoshio Sakka (NIMS) and Shu Yamaguchi (University of Tokyo), I welcome Harald F Krug as the new Co-Editor-in-Chief of STAM. I am also pleased to learn that the year 2014 not only marks the 15th anniversary of STAM, but also the 150th anniversary of the establishment of diplomatic relations between Japan and Switzerland. Toyonobu Yoshida Advances in materials science are key for the sustainable development of our society. That is why, starting from January 2014, Empa, the Swiss Federal Laboratories for Materials Science and Technology, have engaged in an entirely new field of activity: scientific publishing. As mentioned above, Empa joined NIMS in the publishing of STAM. We have a clear-cut goal in mind: we want to support our sister

  2. EDITORIAL: STAM celebrates its 10th anniversary STAM celebrates its 10th anniversary

    Science.gov (United States)

    Ushioda, Sukekatsu

    2010-02-01

    I would like to extend my warmest greetings to the readers and staff of Science and Technology of Advanced Materials (STAM), on the occasion of its 10th anniversary. Launched in 2000, STAM marks this year an important milestone in its history. This is a great occasion to celebrate. STAM was founded by Tsuyoshi Masumoto in collaboration with Teruo Kishi and Toyonobu Yoshida as a world-class resource for the materials science community. It was initially supported by several materials research societies and was published as a regular peer-reviewed journal. Significant changes occurred in 2008, when the National Institute for Materials Science (NIMS) became solely responsible for all the costs of maintaining the journal. STAM was transformed into an open-access journal published by NIMS in partnership with IOP Publishing. As a result, the publication charges were waived and the entire STAM content, including all back issues, became freely accessible through the IOP Publishing website. The transition has made STAM more competitive and successful in global publication communities, with innovative ideas and approaches. The journal has also changed its publication strategy, aiming to publish a limited number of high-quality articles covering the frontiers of materials science. Special emphasis has been placed on reviews and focus issues, providing recent summaries of hot materials science topics. Publication has become electronic only; however, selected issues are printed and freely distributed at major international scientific events. The Editorial Board has been expanded to include leading experts from all over the world and, together with the Editorial Office, the board members are doing their best to transform STAM into a leading materials science journal. These efforts are paying off, as shown by the rapidly increasing number of article downloads and citations in 2009. I believe that the STAM audience can not only deepen their knowledge in their own specialties but

  3. Barnehagelærere og stamming: Erfaringer og oppfatninger.

    OpenAIRE

    Vernang, Daniel

    2016-01-01

    Bacheloroppgave, barnehagelærerutdanning, 2016. Norsk: I denne bacheloroppgaven tar jeg opp temaet stamming i barnehagen. Erfaringene og oppfatningene til barnehagelærere er det som blir lagt fokus på, i lys av stamming hos barnehagebarn. Problemstillingen er hvordan erfarer og oppfatter barnehagelærere stamming hos barnehagebarn. For å få svar på dette, har tre barnehagelærere blitt intervjuet. På bakgrunn av intervjuet, består analysen av følgene temaer: Kunnskap om stamming, samarbei...

  4. El hombre borrado. Mart Stam y la creatividad colectiva

    Directory of Open Access Journals (Sweden)

    Pablo López Martín

    2016-10-01

    Full Text Available El arquitecto holandés Mart Stam fue un outsider del Movimiento Moderno. Comúnmente encasillado en su papel de instigador del ala más dura e intransigente del determinismo racionalista, fue sin embargo un creador original, dotado de un particular talento en todas las escalas. Su propia idea de la disciplina, cercana a la actividad científica, cuya meta es la contribución desinteresada y anónima a un saber universal, ha resultado ser crucial para que su participación en algunas de las páginas más brillantes de la modernidad haya sido relegada a un papel testimonial.

  5. Gerontechnology acceptance by elderly Hong Kong Chinese: a senior technology acceptance model (STAM).

    Science.gov (United States)

    Chen, Ke; Chan, Alan Hoi Shou

    2014-01-01

    The purpose of this study was to develop and test a senior technology acceptance model (STAM) aimed at understanding the acceptance of gerontechnology by older Hong Kong Chinese people. The proposed STAM extended previous technology acceptance models and theories by adding age-related health and ability characteristics of older people. The proposed STAM was empirically tested using a cross-sectional questionnaire survey with a sample of 1012 seniors aged 55 and over in Hong Kong. The result showed that STAM was strongly supported and could explain 68% of the variance in the use of gerontechnology. For older Hong Kong Chinese, individual attributes, which include age, gender, education, gerontechnology self-efficacy and anxiety, and health and ability characteristics, as well as facilitating conditions explicitly and directly affected technology acceptance. These were better predictors of gerontechnology usage behaviour (UB) than the conventionally used attitudinal factors (usefulness and ease of use).

  6. Brasil, estudos pós-coloniais e contracorrentes análogas: entrevista com Ella Shohat e Robert Stam

    NARCIS (Netherlands)

    dos Santos, E.R.S.; Schor, P.

    2013-01-01

    Interview with Ella Shohat and Robert Stam (Portuguese translation). Original version: Brazil is not Traveling Enough”: On Postcolonial Theory and Analogous Counter-Currents (http://www2.let.uu.nl/solis/psc/P/PVOLUMEFOUR/PVOLUMEFOURPAPERS/P4SHOHAT-STAM-INTERVIEW.pdf)

  7. The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.

    Directory of Open Access Journals (Sweden)

    Hélène Chanut-Delalande

    Full Text Available BACKGROUND: Endocytosis is a key regulatory step of diverse signalling pathways, including receptor tyrosine kinase (RTK signalling. Hrs and Stam constitute the ESCRT-0 complex that controls the initial selection of ubiquitinated proteins, which will subsequently be degraded in lysosomes. It has been well established ex vivo and during Drosophila embryogenesis that Hrs promotes EGFR down regulation. We have recently isolated the first mutations of stam in flies and shown that Stam is required for air sac morphogenesis, a larval respiratory structure whose formation critically depends on finely tuned levels of FGFR activity. This suggest that Stam, putatively within the ESCRT-0 complex, modulates FGF signalling, a possibility that has not been examined in Drosophila yet. PRINCIPAL FINDINGS: Here, we assessed the role of the Hrs/Stam complex in the regulation of signalling activity during Drosophila development. We show that stam and hrs are required for efficient FGFR signalling in the tracheal system, both during cell migration in the air sac primordium and during the formation of fine cytoplasmic extensions in terminal cells. We find that stam and hrs mutant cells display altered FGFR/Btl localisation, likely contributing to impaired signalling levels. Electron microscopy analyses indicate that endosome maturation is impaired at distinct steps by hrs and stam mutations. These somewhat unexpected results prompted us to further explore the function of stam and hrs in EGFR signalling. We show that while stam and hrs together downregulate EGFR signalling in the embryo, they are required for full activation of EGFR signalling during wing development. CONCLUSIONS/SIGNIFICANCE: Our study shows that the ESCRT-0 complex differentially regulates RTK signalling, either positively or negatively depending on tissues and developmental stages, further highlighting the importance of endocytosis in modulating signalling pathways during development.

  8. Lotte Stam-Beese (1903-1988) : from 'Entwurfsarchitektin' to urban-planning architect

    NARCIS (Netherlands)

    Oosterhof, J.

    The Silesian-born urban-planning architect Lotte Stam-Beese became famous not only in the Netherlands, but also in CIAM (Congrès Internationaux d’Architecture Moderne) circles, for her designs for modern post-war housing districts in the Dutch city of Rotterdam. The path she travelled to get there

  9. Development of a Trypanosoma cruzi strain typing assay using MS2 peptide spectral libraries (Tc-STAMS2).

    Science.gov (United States)

    de Oliveira, Gilberto Santos; Kawahara, Rebeca; Rosa-Fernandes, Livia; Mule, Simon Ngao; Avila, Carla Cristi; Teixeira, Marta M G; Larsen, Martin R; Palmisano, Giuseppe

    2018-04-01

    Chagas disease also known as American trypanosomiasis is caused by the protozoan Trypanosoma cruzi. Over the last 30 years, Chagas disease has expanded from a neglected parasitic infection of the rural population to an urbanized chronic disease, becoming a potentially emergent global health problem. T. cruzi strains were assigned to seven genetic groups (TcI-TcVI and TcBat), named discrete typing units (DTUs), which represent a set of isolates that differ in virulence, pathogenicity and immunological features. Indeed, diverse clinical manifestations (from asymptomatic to highly severe disease) have been attempted to be related to T.cruzi genetic variability. Due to that, several DTU typing methods have been introduced. Each method has its own advantages and drawbacks such as high complexity and analysis time and all of them are based on genetic signatures. Recently, a novel method discriminated bacterial strains using a peptide identification-free, genome sequence-independent shotgun proteomics workflow. Here, we aimed to develop a Trypanosoma cruzi Strain Typing Assay using MS/MS peptide spectral libraries, named Tc-STAMS2. The Tc-STAMS2 method uses shotgun proteomics combined with spectral library search to assign and discriminate T. cruzi strains independently on the genome knowledge. The method is based on the construction of a library of MS/MS peptide spectra built using genotyped T. cruzi reference strains. For identification, the MS/MS peptide spectra of unknown T. cruzi cells are identified using the spectral matching algorithm SpectraST. The Tc-STAMS2 method allowed correct identification of all DTUs with high confidence. The method was robust towards different sample preparations, length of chromatographic gradients and fragmentation techniques. Moreover, a pilot inter-laboratory study showed the applicability to different MS platforms. This is the first study that develops a MS-based platform for T. cruzi strain typing. Indeed, the Tc-STAMS2 method

  10. On Generalized Stam Inequalities and Fisher–Rényi Complexity Measures

    Directory of Open Access Journals (Sweden)

    Steeve Zozor

    2017-09-01

    Full Text Available Information-theoretic inequalities play a fundamental role in numerous scientific and technological areas (e.g., estimation and communication theories, signal and information processing, quantum physics, … as they generally express the impossibility to have a complete description of a system via a finite number of information measures. In particular, they gave rise to the design of various quantifiers (statistical complexity measures of the internal complexity of a (quantum system. In this paper, we introduce a three-parametric Fisher–Rényi complexity, named ( p , β , λ -Fisher–Rényi complexity, based on both a two-parametic extension of the Fisher information and the Rényi entropies of a probability density function ρ characteristic of the system. This complexity measure quantifies the combined balance of the spreading and the gradient contents of ρ , and has the three main properties of a statistical complexity: the invariance under translation and scaling transformations, and a universal bounding from below. The latter is proved by generalizing the Stam inequality, which lowerbounds the product of the Shannon entropy power and the Fisher information of a probability density function. An extension of this inequality was already proposed by Bercher and Lutwak, a particular case of the general one, where the three parameters are linked, allowing to determine the sharp lower bound and the associated probability density with minimal complexity. Using the notion of differential-escort deformation, we are able to determine the sharp bound of the complexity measure even when the three parameters are decoupled (in a certain range. We determine as well the distribution that saturates the inequality: the ( p , β , λ -Gaussian distribution, which involves an inverse incomplete beta function. Finally, the complexity measure is calculated for various quantum-mechanical states of the harmonic and hydrogenic systems, which are the two main

  11. Zīmola "Lāči" atpazīstamība tirgū un pozīcijas nostiprināšanas iespējas.

    OpenAIRE

    Biezā, Sabīne

    2015-01-01

    Bakalaura darba ‘’Zīmola ‘’Lāči’’ atpazīstamība tirgū un pozīcijas nostiprināšanas iespējas’’ mērķis ir, pamatojoties uz teorijas atziņām par zīmolu un mārketinga komunikācijām zīmola pozīcijas nostiprināšanas kontekstā, kā arī uz patērētāju aptaujas datu rezultātiem, novērtēt zīmola ‘’Lāči’’ atpazīstamību un izstrādāt priekšlikumus zīmola pozīcijas pilnveidošanai. Darba teorētiskais pamatojums balstīts uz literatūru par zīmolvedību, vērtībām, zīmola kapitālu un mārketinga komunikācijām. ...

  12. Mārketinga pasākumu nozīme starptautiska zīmola atpazīstamības veicināšanai Latvijā

    OpenAIRE

    Ozoliņš, Arnis

    2012-01-01

    Darba tēmas izvēle ir saistīta ar būtisku mūsdienu ekonomikas iezīmi - marketinga aktivitāšu un zīmola mijiedarbību. Autors šajā darbā izvirza mērķi noskaidrot starptautiska zīmola atpazīstamības veicinošos faktorus, ir apzinājis zīmola Nike darbību Latvijā, iepazinies ar SIA Sportland mārketinga aktivitātēm un analizējis zīmola izplatību veicinošos pasākumus. Mērķa sasniegšanai tika izvirzīti uzdevumi: noskaidrot mārketinga vidi un preces izvēli veicinošos faktorus, izpētīt un analiz...

  13. Stammingens mange ansikter - En eksplorerende kasusstudie om forskjeller og likheter mellom åpen og skjult stamming

    OpenAIRE

    Siljuberg, Hilde Victoria Møinichen

    2015-01-01

    Bakgrunn og formål: Det er cirka 40.000 personer som stammer i Norge. Det er bred enighet i forskningsfeltet om denne vanskens kompleksitet, ikke minst med den variasjonen som kommer til uttrykk. Nyere faglitteratur åpner for at det kan finnes undergrupper av personer som stammer, og det er derfor av interesse å se nærmere på hvilke former for variasjon det her kan være tale om (Yairi, 2007). Douglass og Quarrington (1952) redegjorde tidlig for sitt skille mellom åpen og skjult sekundærstammi...

  14. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways

    DEFF Research Database (Denmark)

    Pandey, A; Fernandez, M M; Steen, H

    2000-01-01

    In an effort to clone novel tyrosine-phosphorylated substrates of the epidermal growth factor receptor, we have initiated an approach coupling affinity purification using anti-phosphotyrosine antibodies to mass spectrometry-based identification. Here, we report the identification of a signaling m...

  15. PTP1B targets the endosomal sorting machinery

    DEFF Research Database (Denmark)

    Stuible, Matthew; Abella, Jasmine V; Feldhammer, Matthew

    2010-01-01

    Dephosphorylation and endocytic down-regulation are distinct processes that together control the signaling output of a variety of receptor tyrosine kinases (RTKs). PTP1B can directly dephosphorylate several RTKs, but it can also promote activation of downstream pathways through largely unknown...... mechanisms. These positive signaling functions likely contribute to the tumor-promoting effect of PTP1B in mouse cancer models. Here, we have identified STAM2, an endosomal protein involved in sorting activated RTKs for lysosomal degradation, as a substrate of PTP1B. PTP1B interacts with STAM2 at defined...... phosphotyrosine sites, and knockdown of PTP1B expression augments STAM2 phosphorylation. Intriguingly, manipulating the expression and phosphorylation state of STAM2 did not have a general effect on epidermal growth factor (EGF)-induced EGF receptor trafficking, degradation, or signaling. Instead, phosphorylated...

  16. Editorial

    Science.gov (United States)

    Yoshida, Toyonobu

    2013-02-01

    As the successor to Professor Teruo Kishi, the former Editor-in-Chief of Science and Technology of Advanced Materials (STAM), I would like to share some of STAM's journal history with our readers. STAM was launched in 2000 with the financial support of the Japanese Ministry of Education, Culture, Sports, Science and Technology in recognition of a strong need for an international journal that would be distributed and read across the globe. Five years later, the publication of STAM was transferred to the National Institute for Materials Science (NIMS) under the initiative of Professor Kishi. As a result of his work, STAM is now positioned as a high-impact journal, 3.512 as listed by the ISI 2011 Science Citation Index Journal Citation Report, with a much higher and faster growth than when I was participating as a co-founder in the past. STAM is well known as a successful open-access journal since shifting from the initial subscription model in 2008. As an editor, I would like to emphasize that STAM will continue to publish with a sense of social mission as an academic journal, allowing space for researchers to contribute to the sustainable development of society and health. However, some contribution from authors would assist us in creating a sustainable journal publishing model, and further enhance services to authors and readers of STAM. With this in mind, I would like to state that STAM's editorial board is planning to introduce an article processing charge from July 2013, in addition to NIMS' continuing financial support. One of our new editorial policies is to aim for reader-oriented publishing. I believe that academic journal publishing can take the role of navigator in advancing the development of materials. Among the many other scientific journals, STAM will lead the rapid growth in materials science, inspiring research into new materials for the future and leading the next generation of materials science and technology. It is my honor to work with members of

  17. Rényi-Fisher entropy product as a marker of topological phase transitions

    Science.gov (United States)

    Bolívar, J. C.; Nagy, Ágnes; Romera, Elvira

    2018-05-01

    The combined Rényi-Fisher entropy product of electrons plus holes displays a minimum at the charge neutrality points. The Stam-Rényi difference and the Stam-Rényi uncertainty product of the electrons plus holes, show maxima at the charge neutrality points. Topological quantum numbers capable of detecting the topological insulator and the band insulator phases, are defined. Upper and lower bounds for the position and momentum space Rényi-Fisher entropy products are derived.

  18. A Fuzzy Logic Based Method for Analysing Test Results

    Directory of Open Access Journals (Sweden)

    Le Xuan Vinh

    2017-11-01

    Full Text Available Network operators must perform many tasks to ensure smooth operation of the network, such as planning, monitoring, etc. Among those tasks, regular testing of network performance, network errors and troubleshooting is very important. Meaningful test results will allow the operators to evaluate network performanceof any shortcomings and to better plan for network upgrade. Due to the diverse and mainly unquantifiable nature of network testing results, there is a needs to develop a method for systematically and rigorously analysing these results. In this paper, we present STAM (System Test-result Analysis Method which employs a bottom-up hierarchical processing approach using Fuzzy logic. STAM is capable of combining all test results into a quantitative description of the network performance in terms of network stability, the significance of various network erros, performance of each function blocks within the network. The validity of this method has been successfully demonstrated in assisting the testing of a VoIP system at the Research Instiute of Post and Telecoms in Vietnam. The paper is organized as follows. The first section gives an overview of fuzzy logic theory the concepts of which will be used in the development of STAM. The next section describes STAM. The last section, demonstrating STAM’s capability, presents a success story in which STAM is successfully applied.

  19. The psychologist's dilemma ESHHS Paper Utrecht 2010

    NARCIS (Netherlands)

    Van Hezewijk, René; Stam, Henderikus

    2010-01-01

    The Psychologists Dilemma Game René van Hezewijk and Henderikus Stam Among the recurrent cleavages that define 20th century psychology is the deep division between psychologies that distance the psychologist from the phenomenon under investigation from those that engage the question under

  20. The Role of Culture in Entrepreneurial Ecosystems: An Investigation for European Regions

    NARCIS (Netherlands)

    Bosma, N.S.; Holvoet, Tine

    2015-01-01

    Promotion of new entrepreneurial activity has been increasingly visible in many economies across the globe and is currently being shaped by an emerging literature on entrepreneurial ecosystems (see e.g. Stam 2015). In this paper we argue that within the regional entrepreneurship ecosystems

  1. De prijsvorming van hout uit het Nederlandse bos

    NARCIS (Netherlands)

    Slangen, L.H.G.

    1984-01-01

    De prijsvorming van hout op stam en hout geveld uit het Nederlandse bos op het niveau van het bosbedrijf staat centraal in deze publikatie. Na een schets van een aantal facetten die invloed hebben op de prijsvorming wordt nader ingegaan op de prijsvorming zelf. Onderzocht wordt of er verschil in

  2. Experiment list: SRX069112 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX069112 hg19 DNase-seq DNase-Seq Pancreas PANC-1 Tissue=Pancreas/Duct|Disease=Epi...thelioid Carcinoma 35094088,95.1,30.2,36842 GSM736519: Stam PANC-1 2 source_name=PANC-1 || biomaterial_provider=ATCC || cell=PANC...-1 || cell organism=Human || cell description=pancreatic carcinoma. (PMID: 1140870) ||

  3. Experiment list: SRX069110 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available SRX069110 hg19 DNase-seq DNase-Seq Pancreas PANC-1 Tissue=Pancreas/Duct|Disease=Epi...thelioid Carcinoma 36103235,89.9,29.9,48800 GSM736517: Stam PANC-1 1 source_name=PANC-1 || biomaterial_provider=ATCC || cell=PANC...-1 || cell organism=Human || cell description=pancreatic carcinoma. (PMID: 1140870) ||

  4. Oriënterend onderzoek over de reuzen- en dwergplanten in F1 en volgende generaties van Phaseolus vulgaris L. x Phaseolus multiflorus Lam.

    NARCIS (Netherlands)

    Geerts, Sipke Johannes

    1949-01-01

    A cross is studied between the selffertilising bush bean (Phaseolus vulgaris L.) "Zeeuwse Bruine Boon" and crossfertilising runner bean (Phaseolus multiflorus Lam.) "stam" (a scarlet flowering stockrunner-bean) or some other (climbing) runners. With the bushbean as mother this cross easily results

  5. Leadership communication in times of crisis

    NARCIS (Netherlands)

    D.A. Stam (Daan)

    2017-01-01

    textabstractWhat happens when your new research yields the opposite of what your previous research had predicted? This happened to Daan Stam, associate professor of innovation management at Rotterdam School of Management, when he and his colleagues expanded their previous research on communication

  6. Application of mixed models for the assessment genotype and ...

    African Journals Online (AJOL)

    Application of mixed models for the assessment genotype and environment interactions in cotton ( Gossypium hirsutum ) cultivars in Mozambique. ... The cultivars ISA 205, STAM 42 and REMU 40 showed superior productivity when they were selected by the Harmonic Mean of Genotypic Values (HMGV) criterion in relation ...

  7. Department of Pharm

    African Journals Online (AJOL)

    USER

    2016-11-25

    Nov 25, 2016 ... availability of safe water, food safety, good housing and effective management of sewage (Madigan et al., 2002; Stams and Plugge, 2007; WHO, 2014). Improvement on physical environment normally leads to substantial gains in the health status of the people. Therefore, availability of good and accessible ...

  8. Toerisme verrijkt? : een discussie over de relatie tussen toerisme en armoedebestrijding, inleiding

    NARCIS (Netherlands)

    Duim, van der V.R.

    2005-01-01

    Na ecotourism, duurzaam en verantwoord toerisme is er de laatste jaren een nieuwe loot aan de stam gegroeid: pro-poor tourism. Het wordt gedragen door organisaties als: World Tourism Organisation (tijdens de wereldtop in Johannesburg), de SNV (met zo'n 40 toeristische adviseurs over diverse landen

  9. Psychology and evolutionary biology; Causal analysis, evidence, and nomothetic laws

    NARCIS (Netherlands)

    Van Hezewijk, René

    2008-01-01

    Published as a chapter in Van Hezewijk, R. (2003). Psychology and evolutionary biology; Causal analysis, evidence, and nomothetic laws. In N. Stephenson, L. Radtke, R. Jorna & H. J. Stam (Eds.), Theoretical psychology; Critical contributions (pp. 405-415). Concord, Ontario: Captus Press.

  10. Het Fries als voorbeeldige taal - in alle stadia

    NARCIS (Netherlands)

    Versloot, A.P.

    2008-01-01

    ‘In ons Morfo-project proberen we de structuur van de Friese woordenschat bloot te leggen. We verbinden taalelementen die van dezelfde stam zijn afgeleid met elkaar: binnen én tussen de taalstadia. Een voorbeeld is het woord hûs, "huis". Dat zit in het woord útfanhûzje, "logeren", net zo goed als in

  11. Distribution of Wave Loads for Design of Crown Walls in Deep and Shallow Water

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen Quvang Harck; Andersen, Thomas Lykke

    2014-01-01

    This paper puts forward a new method to determine horizontal wave loads on rubble mound breakwater crown walls with specific exceedance probabilities based on the formulae by Nørgaard et al. (2013) as well as presents a new modified version of the wave run-up formula by Van der Meer & Stam (1992)...

  12. Majad moodsalt tänavalt / Tiina Tammet

    Index Scriptorium Estoniae

    Tammet, Tiina, 1971-

    2001-01-01

    1927. a. Stuttgarti ehitatud Weissenhofi elamugrupist (Le Corbusier, P. Jeanneret, J. J. P. Oud, M. Stam, W. Gropius, P. Behrens, M. ja B. Taut jt.) ja 1933. a. valminud Vaarika-Maasika t. asumist (A. Volberg, E. J. Kuusik, E. Jacoby, E. Lohk, F. de Vries). Näitus "Moodsad näidisasumid: Weissenhof & Maasika-Vaarika" Rotermanni soolalaos.

  13. Industrial Dynamics and Economic Geography

    NARCIS (Netherlands)

    Capasso, Marco|info:eu-repo/dai/nl/314016627; Stam, Erik|info:eu-repo/dai/nl/215649370; Cefis, Elena|info:eu-repo/dai/nl/274516233

    2015-01-01

    Capasso M., Stam E. and Cefis E. Industrial dynamics and economic geography, Regional Studies. How do industries emerge and evolve over space? In this special issue the fields of industrial dynamics and economic geography are brought together in order to achieve a richer and more fundamental

  14. Biological effectiveness of pulsed and continuous neutron radiation for cells of yeast Saccharomyces

    International Nuclear Information System (INIS)

    Tsyb, T.S.; Komarova, E.V.; Potetnya, V.I.; Obaturov, G.M.

    2001-01-01

    Data are presented on biological effectiveness of fast neutrons generated by BR-10 reactor (dose rate up to 3.8 Gy/s) in comparison with neutrons of pulsed BARS-6 reactor (dose rate ∼6x10 6 Gy/s) for yeast Saccharomyces vini cells of a wild type Menri 139-B and radiosensitive Saccharomyces cerevisiae (rad52/rad52; rad54/rad54) mutants which are defective over different systems of DNA reparation. Value of relative biological efficiency (RBE) of continuous radiation for wild stam is from 3.5 up to 2.5 when survival level being 75-10 %, and RBE of pulsed neutron radiation is in the limits of 2.0-1.7 at the same levels. For mutant stam the value of RBE (1.4-1.6) of neutrons is constant at all survival levels and does not depend on dose rate [ru

  15. The United States Nuclear Regulatory Commission's vendor inspection program

    International Nuclear Information System (INIS)

    Grier, B.H.

    1977-01-01

    The NRC conducts a program of inspection at licensee contractors and vendors to assure that quality assurance programs meet applicable NRC requirements. This inspection program, which was begun in 1965 and restructured in 1974, is discussed. A trial program has recently been initiated to evaluate the use of the ASME N-stam inspection system to supplement NRC inspections. The criteria for NRC acceptance of such a third party inspection system are described in the paper. (author)

  16. The psychologist's dilemma ESHHS Paper Utrecht 2010

    OpenAIRE

    Van Hezewijk, René; Stam, Henderikus

    2010-01-01

    The Psychologists Dilemma Game René van Hezewijk and Henderikus Stam Among the recurrent cleavages that define 20th century psychology is the deep division between psychologies that distance the psychologist from the phenomenon under investigation from those that engage the question under investigation from the perspective of the reflexive capacities of the psychologist as one among other human beings and/or members of a specific culture. Most obvious was the emergence – in the late nineteent...

  17. The Role of Culture in Entrepreneurial Ecosystems: An Investigation for European Regions

    OpenAIRE

    Bosma, N.S.; Holvoet, Tine

    2015-01-01

    Promotion of new entrepreneurial activity has been increasingly visible in many economies across the globe and is currently being shaped by an emerging literature on entrepreneurial ecosystems (see e.g. Stam 2015). In this paper we argue that within the regional entrepreneurship ecosystems approaches, entrepreneurship culture should be seen as one of the essential elements: we propose that regional entrepreneurship culture represents the glue that links the elements of the entrepreneurial eco...

  18. Palavras, sons e imagens em cartaz: aspectos de intermidialidade no romance Benjamin, de Chico Buarque, e na adaptação cinematográfica de Monique Gardenberg

    Directory of Open Access Journals (Sweden)

    Leila Cristina Barros

    2006-12-01

    presentes e relacionadas intimamente entre si, dentro do filme. A combinação e a fusão dessas relações intertextuais e intermidiáticos, no romance e na adaptação, remetem-nos ao conceito de transtextualidade – desenvolvido por Gérard Genette a partir dos termos “dialogismo”, de Mikhail Bakhtin, e “intertextualidade”, de Julia Kristeva, e apropriado pelo crítico de cinema Robert Stam.

  19. The shortcomings of globalised internet technology in Southern Africa

    CSIR Research Space (South Africa)

    Johnson, David L

    2016-12-01

    Full Text Available , and Maurice Tchuente, editors, Fourth International IEEE EAI Conference on eInfrastructure and eServices for Developing Countries (Africomm 2012), Berlin, Heidelberg, 2012. Springer. 10. Elizabeth M Belding, David L Johnson, Lisa Parks, Veljko Pejovic, Gertjan... Stam settings in provisioning of access to the internet. These targets mostly address issues of connectivity, bandwidth and affordability [3, 4]. Subsequently, several countries have set goals for internet access in their national laws, e.g. South...

  20. Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking

    OpenAIRE

    Lee, Samuel M.; Chin, Lih-Shen; Li, Lian

    2012-01-01

    Mutations in small integral membrane protein of lysosome/late endosome (SIMPLE) cause autosomal dominant, Charcot-Marie-Tooth disease (CMT) type 1C. The cellular function of SIMPLE is unknown and the pathogenic mechanism of SIMPLE mutations remains elusive. Here, we report that SIMPLE interacted and colocalized with endosomal sorting complex required for transport (ESCRT) components STAM1, Hrs, and TSG101 on early endosomes and functioned with the ESCRT machinery in the control of endosome-to...

  1. Post-Stress Combined Administration of Beta-Receptor and Glucocorticoid Antagonists as a Novel Preventive Treatment in an Animal Model of PTSD

    Science.gov (United States)

    2009-07-01

    reduced extinction of cue- conditioned fear. The temporal characteristics of the model must be amenable to testing acute drug treatment in the...that is sensitive to both enhanced and attenuated fear conditioning and extinction -Established a drug treatment regimen that is feasible in the...nonassociative theories of the UCS preexposure phenomenon: Implications for Pavlovian conditioning . Psychol Bull 86: 523-548 Stam R (2007) PTSD and stress

  2. Highly efficient and large-scale fabrication of superhydrophobic alumina surface with strong stability based on self-congregated alumina nanowires.

    Science.gov (United States)

    Peng, Shan; Tian, Dong; Yang, Xiaojun; Deng, Wenli

    2014-04-09

    In this study, a large-area superhydrophobic alumina surface with a series of superior properties was fabricated via an economical, simple, and highly effective one-step anodization process, and subsequently modified with low-surface-energy film. The effects of the anodization parameters including electrochemical anodization time, current density, and electrolyte temperature on surface morphology and surface wettability were investigated in detail. The hierarchical alumina pyramids-on-pores (HAPOP) rough structure which was produced quickly through the one-step anodization process together with a low-surface-energy film deposition [1H,1H,2H,2H-perfluorodecyltriethoxysilane (PDES) and stearic acid (STA)] confer excellent superhydrophobicity and an extremely low sliding angle. Both the PDES-modified superhydrophobic (PDES-MS) and the STA-modified superhydrophobic (STA-MS) surfaces present fascinating nonwetting and extremely slippery behaviors. The chemical stability and mechanical durability of the PDES-MS and STA-MS surfaces were evaluated and discussed. Compared with the STA-MS surface, the as-prepared PDES-MS surface possesses an amazing chemical stability which not only can repel cool liquids (water, HCl/NaOH solutions, around 25 °C), but also can show excellent resistance to a series of hot liquids (water, HCl/NaOH solutions, 30-100 °C) and hot beverages (coffee, milk, tea, 80 °C). Moreover, the PDES-MS surface also presents excellent stability toward immersion in various organic solvents, high temperature, and long time period. In particular, the PDES-MS surface achieves good mechanical durability which can withstand ultrasonication treatment, finger-touch, multiple fold, peeling by adhesive tape, and even abrasion test treatments without losing superhydrophobicity. The corrosion resistance and durability of the diverse-modified superhydrophobic surfaces were also examined. These fascinating performances makes the present method suitable for large

  3. Thermal properties of graphite oxide, thermally reduced graphene and chemically reduced graphene

    Science.gov (United States)

    Jankovský, Ondřej; Sedmidubský, David; Lojka, Michal; Sofer, Zdeněk

    2017-07-01

    We compared thermal behavior and other properties of graphite oxide, thermally reduced graphene and chemically reduced graphene. Graphite was oxidized according to the Hofmann method using potassium chlorate as oxidizing agent in strongly acidic environment. In the next step, the formed graphite oxide was chemically or thermally reduced yielding graphene. The mechanism of thermal reduction was studied using STA-MS. Graphite oxide and both thermally and chemically reduced graphenes were analysed by SEM, EDS, elemental combustion analysis, XPS, Raman spectroscopy, XRD and BET. These findings will help for the large scale production of graphene with appropriate chemical composition.

  4. My American Uncle, America Cries Uncle, and Other Fantastic Tales from France: Iegor Gran's Jeanne d'Arc fait tic-tac

    OpenAIRE

    Carolyn A. Durham

    2008-01-01

    Ella Shohat and Robert Stam's proposal that beliefs about nations often crystallize in the form of stories could serve as both summary and generative matrix for Jeanne d'Arc fait tic-tac . In keeping with a number of recent fictional works united by the attempt to understand French and American cultures in a comparative context, the first part of Iegor Gran's clever 2005 novel consists of eleven stories whose common focus on the danger represented by American culture for French national iden...

  5. Data driven mathematical models for policy making

    OpenAIRE

    Nannyonga, Betty

    2011-01-01

    This thesis consists of two papers. 1. Betty Nannyonga, D.J.T. Sumpter, J.Y.T. Mugisha and L.S. Luboobi: The Dynamics,causes and possible prevention of Hepaititis E outbreaks. 2. Betty Nannyonga, D.J.T. Sumpter, andStam Nicolis: A dynamical systems approach tosocial and economic development. The first paper deals with a deterministic approach of modelling a Hepatitis E outbreak whenmalaria is endemic in a population. We design three models based on the epidemiology ofHepatitis E, malaria, and...

  6. NAVIER-STOKES EM GPU

    OpenAIRE

    ALEX LAIER BORDIGNON

    2006-01-01

    Nesse trabalho, mostramos como simular um fluido em duas dimensões em um domínio com fronteiras arbitrárias. Nosso trabalho é baseado no esquema stable fluids desenvolvido por Joe Stam. A implementação é feita na GPU (Graphics Processing Unit), permitindo velocidade de interação com o fluido. Fazemos uso da linguagem Cg (C for Graphics), desenvolvida pela companhia NVidia. Nossas principais contribuições são o tratamento das múltiplas fronteiras, o...

  7. Vi snakker jo mye om det, hva er det du kjenner på nå, hvor er det det oppstår?

    OpenAIRE

    Meek, Nina Persson

    2015-01-01

    Bakgrunn og formål Forskning har vist at ungdom som stammer opplever i stor grad negative følelser og tanker omkring egen stamming (Menzies, Onslow, Packman and O´Brian, 2009; Helliesen, 2006). Ettersom det er en bred enighet på feltet om at en individuell oppfølging og tilrettelegging er viktig for å møte de utfordringene ungdommene som stammer har (Manning & DiLollo, 2007; Howie, 2011; Hearne, Packman, Onslow & Quine, 2008), var det av interesse å undersøke om ungdom opplever at behandling ...

  8. Health psychology in autobiography: Three Canadian critical narratives.

    Science.gov (United States)

    Stam, Henderikus J; Murray, Michael; Lubek, Ian

    2018-03-01

    Three Canadian colleagues in health psychology recount their careers in a field of research and practice whose birth they witnessed and whose developments they have critiqued. By placing the development of health psychology in Canada in a context that is both institutional and personal, Stam, Murray, and Lubek raise a series of questions about health psychology and its propagation. While uniquely Canadian their professional careers were affected by international colleagues as well as others-patients and community members-whose views shaped their perspectives. This article is a plea for the continuing development of critical voices in health psychology.

  9. EFFETS D'UN DEFICIT HYDRIQUE SUR CERTAINS ...

    African Journals Online (AJOL)

    AISA

    Le cotonnier est connu pour sa sensibilité au déficit hydrique. Le présent travail a été initié afin de mesurer les effets de ce facteur chez la variété STAM129A de cotonnier vulgarisée au Togo. L'étude porte sur certains paramètres tels que la hauteur des plantes, la longueur des entrenœuds, le taux de rétention des ...

  10. "I am in control of my life": the male homosexual stereotype in the movies A Navalha na carne (1969 and a Rainha Diaba (1974 "Na minha vida, mando eu": o estereótipo do homossexual masculino nos filmes A navalha na carne (1969 e A Rainha Diaba (1974

    Directory of Open Access Journals (Sweden)

    Rafael de Luna Freire

    2009-09-01

    Full Text Available "I am in control of my life": the male homosexual stereotype in the movies A Navalha na Carne (1969 and A Rainha Diaba (1974 — This paper discusses the question of male homosexual stereotyping in Brazilian cinema, taking as the object of study the homosexual characters of the movies A navalha na carne (directed by Braz Chediak, 1970 and A Rainha Diaba (directed by Antonio Carlos da Fontoura, 1974, based on the works of the author Plínio Marcos. Using texts by authors such as Richard Dyer, Robert Stam and Ella Shohat, I defend the need and importance of a historiographical analysis of stereotypes in cinema. O presente artigo discute a questão do estereótipo do homossexual masculino no cinema brasileiro, tomando como objeto de estudo os personagens homossexuais dos filmes A navalha na carne (1970 e A Rainha Diaba (1974, baseados em obras do autor santista Plínio Marcos. Através de textos de autores como Richard Dyer, Robert Stam e Ella Shohat, defendo a necessidade e a importância de uma análise historicizante dos estereótipos no cinema.

  11. NAS TEIAS DA INTERMIDIALIDADE: O CARANDIRU DE VARELLA E O DE BABENCO

    Directory of Open Access Journals (Sweden)

    Norma de Siqueira Freitas

    2009-12-01

    Full Text Available RESUMO: Reflexão sobre o processo de adaptação de obras da literatura, transmutadas para a linguagem cinematográfica. O objetivo é a análise do trânsito entre os textos: Estação Carandiru (EC, livro de Drauzio Varella e o filme Carandiru, de Hector Babenco. Analisaremos o deslocamento do signo verbal ao visual a partir dos pressupostos de Andrew, Bazin, Gardies, Genette e Stam. Em diálogo com as principais teorias do cinema, adaptação concebida, então, como recriação, porquanto mudança de veículos artísticos exigirá processo de transformação pertinente. PALAVRAS-CHAVE: literatura, cinema, adaptação, linguagem. ABSTRACT:Thisarticleisareflectionontheprocessoftheadaptation of literary works by their transmutation into cinematic language. It intends to analyze the transit between two texts: Drauzio Varella’s book Estação Carandiru (EC and Hector Babenco’s film Carandiru. The displacement from the verbal to the visual sign will be analyzed by way of the theories of Andrew, Bazin, Gardies, Genette and Stam. Following the main theories on cinema, adaptation is conceived as re-creation, since a change in artistic vehicles requires a pertinent transformation process. KEYWORDS: literature, cinema, adaptation, language.

  12. Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas

    Directory of Open Access Journals (Sweden)

    Anna Kakehashi

    2017-02-01

    Full Text Available To uncover mechanisms of nonalcoholic steatohepatitis (NASH associated hepatocarcinogenesis, we compared the proteomes of human NASH-associated liver biopsies, resected hepatocellular carcinomas (HCCs and HCCs of HCV+ patients with normal liver tissue of patients with gastrointestinal tumor metastasis, in formalin-fixed paraffin-embedded samples obtained after surgery in our hospital during the period from 2006 to 2011. In addition, proteome analysis of liver tumors in male STAM NASH-model mice was performed. Similar changes in the proteome spectrum such as overexpression of enzymes involved in lipid, cholesterol and bile acid biosynthesis and examples associated with suppression of fatty acid oxidation and catabolism, alcohol metabolism, mitochondrial function as well as low expression levels of cytokeratins 8 and 18 were observed in both human NASH biopsies and NASH HCCs, but not HCV+ HCCs. Alterations in downstream protein expression pointed to significant activation of transforming growth factor β, SMAD family member 3, β-catenin, Nrf2, SREBP-LXRα and nuclear receptor-interacting protein 1 (NRIP1, and inhibition of PPARs and p53 in human NASH biopsies and/or HCCs, suggesting their involvement in accumulation of lipids, development of fibrosis, oxidative stress, cell proliferation and suppression of apoptosis in NASH hepatocarcinogenesis. In STAM mice, PPARs inhibition was not obvious, while expression of cytokeratins 8 and 18 was elevated, indicative of essential differences between human and mouse NASH pathogenesis.

  13. Um outro olhar: aspectos contrahegemônicos no filme Bem-vindo = Another look: aspects of counterhegemony into the movie Welcome

    Directory of Open Access Journals (Sweden)

    Oliveira, Eliane Maria de

    2013-01-01

    Full Text Available Os atentados terroristas de 11 de setembro de 2001 reinseriram a questão imigratória nos meios de comunicação, juntamente com temáticas relacionadas à (in segurança e ao (desemprego. O estrangeiro, o outro, passou a ser caracterizado como ameaça em um sistema discursivo que mesclava ficção e realidade: tanto em filmes quanto em noticiários, o imigrante passava a ser apresentado como um problema a ser resolvido, em discursos que se reforçavam, constituindo o que pode ser denominado como discurso hegemônico. Neste trabalho, tendo como referencial teórico Gramsci e Robert Stam, buscamos identificar aspectos de um discurso contrahegemônico no filme Bem-vindo

  14. The Conditional Entropy Power Inequality for Bosonic Quantum Systems

    DEFF Research Database (Denmark)

    de Palma, Giacomo; Trevisan, Dario

    2018-01-01

    We prove the conditional Entropy Power Inequality for Gaussian quantum systems. This fundamental inequality determines the minimum quantum conditional von Neumann entropy of the output of the beam-splitter or of the squeezing among all the input states where the two inputs are conditionally...... independent given the memory and have given quantum conditional entropies. We also prove that, for any couple of values of the quantum conditional entropies of the two inputs, the minimum of the quantum conditional entropy of the output given by the conditional Entropy Power Inequality is asymptotically...... achieved by a suitable sequence of quantum Gaussian input states. Our proof of the conditional Entropy Power Inequality is based on a new Stam inequality for the quantum conditional Fisher information and on the determination of the universal asymptotic behaviour of the quantum conditional entropy under...

  15. Veikala lojalitātes programmas iOS lietotne

    OpenAIRE

    Freibergs, Kristaps

    2013-01-01

    Pasaulē izmantoto tehnoloģiju klāstam augot, ir pieaudzis arī mobilo ierīču piedāvājums un to iespējas. Salīdzinoši lielu daļu tirgus ir iekarojusi Apple Inc. ar savu produkciju, tai skaitā iPhone viedtālruņiem. Šajā kvalifikācijas darbā tiek aprakstīta un izstrādāta iPhone ierīces lietotne veikala lojalitātes programmas realizācijai. Lietotnes mērķis ir popularizēt konkrēto veikalu, piedāvājot dažādas lietotājam saistošas funkcijas, tai skaitā, apskatīt tuvākos veikalus, izveidot iepirkumu g...

  16. Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

    Directory of Open Access Journals (Sweden)

    Eunice Yuen Ting Lau

    2016-05-01

    Full Text Available Like normal stem cells, tumor-initiating cells (T-ICs are regulated extrinsically within the tumor microenvironment. Because HCC develops primarily in the context of cirrhosis, in which there is an enrichment of activated fibroblasts, we hypothesized that cancer-associated fibroblasts (CAFs would regulate liver T-ICs. We found that the presence of α-SMA(+ CAFs correlates with poor clinical outcome. CAF-derived HGF regulates liver T-ICs via activation of FRA1 in an Erk1,2-dependent manner. Further functional analysis identifies HEY1 as a direct downstream effector of FRA1. Using the STAM NASH-HCC mouse model, we find that HGF-induced FRA1 activation is associated with the fibrosis-dependent development of HCC. Thus, targeting the CAF-derived, HGF-mediated c-Met/FRA1/HEY1 cascade may be a therapeutic strategy for the treatment of HCC.

  17. [Influence of ski boots on balance performance].

    Science.gov (United States)

    Mildner, E; Lembert, S; Raschner, C

    2010-03-01

    Modern ski carving technique demands that skiers have a strong sense of balance and edge their skis with precision and feeling. Stiff ski boots facilitate the transfer of power to the ski but increase the difficulty of balancing. The aim of this study was to analyse the influence of ski boots on balance performance of alpine skiers. 76 experienced skiers (female 33/male 43) and 76 ski racers of the Skigymnasium Stams (female 31/male 45) were tested on the MFT S 3 Check with and without ski boots. Ski boots significantly influenced balance. There were also significant differences between experienced skiers and ski racers, but gender differences were minimal. In addition to general conditioning, skiers should utilise general and ski-specific balance and sensomotor training which could help in ski injury prevention, especially knee injuries. Georg Thieme Verlag KG Stuttgart, New York.

  18. «Nos damos por convidados», la voz de los esclavos en la hacienda «El Paraíso»

    Directory of Open Access Journals (Sweden)

    Nara Fuentes Crispín

    2006-01-01

    Full Text Available Apoyado en James Scott y Robert Stam, entre otros, este artículo constituye una propuesta de lectura del clásico colombiano María de Jorge Isaacs. El narrador de la novela crea un discurso que impide apreciar las voces y la cultura de los esclavos negros. Este ocultamiento puede deberse a dos razones. Primero, el escenario es una hacienda del siglo XIX, institución que conservó la mentalidad terrateniente y paternalista del periodo colonial de la Nueva Granada. Segundo, la ficcionalización romántica recrea condiciones culturales especiales: la mirada del narrador describe la cultura de los esclavos privilegiando solo los elementos compatibles con el mundo de los amos. Se trata de dos visiones de mundo y de la imposición de la visión dominante. Aún así, en esta propuesta podremos ver, en negativo, algunas estrategias subalternas.

  19. Ubiquitin regulates GGA3-mediated degradation of BACE1.

    Science.gov (United States)

    Kang, Eugene L; Cameron, Andrew N; Piazza, Fabrizio; Walker, Kendall R; Tesco, Giuseppina

    2010-07-30

    BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of beta-amyloid, a toxic peptide that accumulates in the brain of subjects affected by Alzheimer disease. The BACE1 C-terminal fragment contains a DXXLL motif that has been shown to bind the VHS (VPS27, Hrs, and STAM) domain of GGA1-3 (Golgi-localized gamma-ear-containing ARF-binding proteins). GGAs are trafficking molecules involved in the transport of proteins containing the DXXLL signal from the Golgi complex to endosomes. Moreover, GGAs bind ubiquitin and traffic synthetic and endosomal ubiquitinated cargoes to lysosomes. We have previously shown that depletion of GGA3 results in increased BACE1 levels and activity because of impaired lysosomal degradation. Here, we report that the accumulation of BACE1 is rescued by the ectopic expression of GGA3 in H4 neuroglioma cells depleted of GGA3. Accordingly, the overexpression of GGA3 reduces the levels of BACE1 and beta-amyloid. We then established that mutations in the GGA3 VPS27, Hrs, and STAM domain (N91A) or in BACE1 di-leucine motif (L499A/L500A), able to abrogate their binding, did not affect the ability of ectopically expressed GGA3 to rescue BACE1 accumulation in cells depleted of GGA3. Instead, we found that BACE1 is ubiquitinated at lysine 501 and is mainly monoubiquitinated and Lys-63-linked polyubiquitinated. Finally, a GGA3 mutant with reduced ability to bind ubiquitin (GGA3L276A) was unable to regulate BACE1 levels both in rescue and overexpression experiments. These findings indicate that levels of GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery.

  20. Ubiquitin Regulates GGA3-mediated Degradation of BACE1*

    Science.gov (United States)

    Kang, Eugene L.; Cameron, Andrew N.; Piazza, Fabrizio; Walker, Kendall R.; Tesco, Giuseppina

    2010-01-01

    BACE1 (β-site amyloid precursor protein-cleaving enzyme 1) is a membrane-tethered member of the aspartyl proteases, essential for the production of β-amyloid, a toxic peptide that accumulates in the brain of subjects affected by Alzheimer disease. The BACE1 C-terminal fragment contains a DXXLL motif that has been shown to bind the VHS (VPS27, Hrs, and STAM) domain of GGA1–3 (Golgi-localized γ-ear-containing ARF-binding proteins). GGAs are trafficking molecules involved in the transport of proteins containing the DXXLL signal from the Golgi complex to endosomes. Moreover, GGAs bind ubiquitin and traffic synthetic and endosomal ubiquitinated cargoes to lysosomes. We have previously shown that depletion of GGA3 results in increased BACE1 levels and activity because of impaired lysosomal degradation. Here, we report that the accumulation of BACE1 is rescued by the ectopic expression of GGA3 in H4 neuroglioma cells depleted of GGA3. Accordingly, the overexpression of GGA3 reduces the levels of BACE1 and β-amyloid. We then established that mutations in the GGA3 VPS27, Hrs, and STAM domain (N91A) or in BACE1 di-leucine motif (L499A/L500A), able to abrogate their binding, did not affect the ability of ectopically expressed GGA3 to rescue BACE1 accumulation in cells depleted of GGA3. Instead, we found that BACE1 is ubiquitinated at lysine 501 and is mainly monoubiquitinated and Lys-63-linked polyubiquitinated. Finally, a GGA3 mutant with reduced ability to bind ubiquitin (GGA3L276A) was unable to regulate BACE1 levels both in rescue and overexpression experiments. These findings indicate that levels of GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery. PMID:20484053

  1. Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy.

    Science.gov (United States)

    Ochodnicky, Peter; Lattenist, Lionel; Ahdi, Mohamed; Kers, Jesper; Uil, Melissa; Claessen, Nike; Leemans, Jaklien C; Florquin, Sandrine; Meijers, Joost C M; Gerdes, Victor E A; Roelofs, Joris J T H

    2017-09-01

    TAM receptors (Tyro3, Axl, and Mer) have been implicated in innate immunity. Circulating TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to autoimmune disorders. We investigated TAM and their ligand protein S in patients with diabetes. Urinary and plasma levels of protein S, sTyro3, sAxl, and sMer were determined in 126 patients with diabetes assigned to a normoalbuminuric or macroalbuminuric (urinary albumin excretion 300 mg/24 hours, respectively) study group and 18 healthy volunteers. TAM and protein S immunostaining was performed on kidney biopsy specimens from patients with diabetic nephropathy (n = 9) and controls (n = 6). TAM expression and shedding by tubular epithelial cells were investigated by PCR and enzyme-linked immunosorbent assay in an in vitro diabetes model. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary sTyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer expression in diabetic nephropathy tissue and glomerular depositions of protein S. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer mRNA and increased shedding of sTyro3 and sMer. Renal injury in diabetes is associated with elevated systemic and urine levels of sMer and sTyro3. This is the first study reporting excretion of sTAM receptors in urine, identifying the kidney as a source of sTAM. Copyright © 2017 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  2. Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product

    Directory of Open Access Journals (Sweden)

    Leonid V. Omelyanchuk

    2009-10-01

    Full Text Available Hepatocyte growth factor receptor tyrosine kinase substrate (HRS is an endosomal protein required for trafficking receptor tyrosine kinases from the early endosome to the lysosome. HRS interacts with Merlin, the Neurofibromatosis 2 (NF2 gene product, and this interaction may be important for Merlin’s tumor suppressor activity. Understanding the evolution, origin, and structure of HRS may provide new insight into Merlin function. We show that HRS homologs are present across a wide range of Metazoa with the yeast Vps27 protein as their most distant ancestor. The phylogenetic tree of the HRS family coincides with species evolution and divergence, suggesting a unique function for HRS. Sequence alignment shows that various protein domains of HRS, including the VHS domain, the FYVE domain, the UIM domain, and the clathrin-binding domain, are conserved from yeast to multicellular organisms. The evolutionary transition from unicellular to multicellular organisms was accompanied by the appearance of a binding site for Merlin, which emerges in the early Metazoa after its separation from flatworms. In addition to the region responsible for growth suppression, the Merlin-binding and STAM-binding domains of HRS are conserved among multicellular organisms. The residue equivalent to tyrosine-377, which is phosphorylated in the human HRS protein, is highly conserved throughout the HRS family. Three additional conserved boxes lacking assigned functions are found in the HRS proteins of Metazoa. While boxes 1 and 3 may constitute the Eps-15- and Snx1-binding sites, respectively, box 2, containing the residue equivalent to tyrosine-377, is likely to be important for HRS phosphorylation. While several functional domains are conserved throughout the HRS family, the STAM-binding, Merlin-binding, and growth suppression domains evolved in the early Metazoa around the time the Merlin protein emerged. As these domains appear during the transition to multicellularity

  3. A New Way to Lemmatize Adjectives in a User-friendly Zulu–English Dictionary

    Directory of Open Access Journals (Sweden)

    Gilles-Maurice de Schryver

    2011-10-01

    Full Text Available

    Abstract: Traditionally, Zulu adjectives have been lemmatized under their stems only. In this research article, an in-depth analysis is undertaken to make a case for the lemmatization of all frequent adjectival forms with their adjective concords rather. It is shown that the supposed explosion in size of the dictionary may be contained within a corpus-driven Sinclairian framework. The advantages of such a word-like treatment far outnumber the generalizations that have hitherto characterized the lexicographic treatment of adjectives in Zulu. The study is supported by ample dictionary extracts from a Zulu–English dictionary project aimed at junior users. Comparisons with existing dictionaries and textbook data are also made.

    Keywords: LEXICOGRAPHY, LINGUISTICS, GRAMMAR, DICTIONARY, BILINGUAL,CORPUS, LEMMATIZATION, FREQUENCY, ZULU (ISIZULU, ENGLISH, ADJECTIVE,ADJECTIVE STEM, QUALIFICATIVE ADJECTIVE, COPULATIVE ADJECTIVE, USER-FRIENDLY,REAL EXAMPLE, COLLOCATION, COMBINATION, DERIVATION, IDIOMATIC USE,SEMANTIC PROSODY

    Samenvatting: Een nieuwe manier om adjectieven te lemmatiseren in eengebruiksvriendelijk Zoeloe–Engels woordenboek. Traditioneel worden adjectievenin Zoeloe enkel onder hun stam gelemmatiseerd. In dit onderzoeksartikel wordt een grondigeanalyse uitgevoerd met het oog op de invoering van een nieuwe methode waarbij alle frequenteadjectieven met hun adjectiefschakel in het woordenboek worden geplaatst. Er wordt aangetoond datde vooronderstelde explosie in grootte van het woordenboek beperkt kan worden binnen een corpusgedrevenSinclairiaans kader. De voordelen van zo een woordachtige behandeling overstijgenruimschoots de veralgemeningen die totnogtoe de lexicografische behandeling van adjectieven inZoeloe hebben gekarakteriseerd. De studie wordt ondersteund door een groot aantal passages uiteen Zoeloe–Engels woordenboekproject gericht op jonge gebruikers. Vergelijkingen met bestaandewoordenboeken, alsook handboeken

  4. Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.

    Science.gov (United States)

    Luo, Xiucui; Pan, Jing; Wang, Leilei; Wang, Peirong; Zhang, Meijiao; Liu, Meilin; Dong, Ziqing; Meng, Qian; Tao, Xuguang; Zhao, Xinliang; Zhong, Julia; Ju, Weina; Gu, Yang; Jenkins, Edmund C; Brown, W Ted; Shi, Qingxi; Zhong, Nanbert

    2015-02-15

    Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human placentas derived from PPROM, PTB, premature rupture of the membranes (PROM), and full-term birth (FTB), and determined the major biological pathways involved in PPROM. Here, we further investigated the relationship of lncRNAs, which are differentially expressed in spontaneous PTB (sPTB) and PPROM placentas and are found to overlap a coding locus, with the differential expression of transcribed mRNAs at the same locus. Ten lncRNAs (five up-regulated and five down-regulated) and the lncRNA-associated 10 mRNAs (six up- and four down-regulated), which were identified by microarray in comparing PPROM vs. sPTB, were then validated by real-time quantitative PCR. A total of 62 (38 up- and 24 down-regulated) and 1,923 (790 up- and 1,133 down-regulated) lncRNAs were identified from placentas of premature labor (sPTB + PPROM), as compared to those from full-term labor (FTB + PROM) and from premature rupture of membranes (PPROM + PROM), as compared to those from non-rupture of membranes (sPTB + FTB), respectively. We found that a correlation existed between differentially expressed lncRNAs and their associated mRNAs, which could be grouped into four categories based on the gene strand (sense or antisense) of lncRNA and its paired transcript. These findings suggest that lncRNA regulates mRNA transcription through differential mechanisms. Differential expression of the transcripts PPP2R5C, STAM, TACC2, EML4, PAM, PDE4B, STAM, PPP2R5C, PDE4B, and EGFR indicated a co-expression among these mRNAs, which are involved in the ubiquitine-proteasome system (UPS), in addition to signaling transduction and beta adrenergic signaling, suggesting that imbalanced regulation of UPS may present an additional mechanism underlying the premature rupture of membrane in PPROM

  5. Revolutionizing Bantu Lexicography — A Zulu Case Study

    Directory of Open Access Journals (Sweden)

    Gilles-Maurice de Schryver

    2011-10-01

    Full Text Available

    ABSTRACT: Zulu uses a conjunctive writing system, that is, a system whereby relatively short linguistic words are joined together to form long orthographic words with complex morphological structures. This has led to the so-called 'stem tradition' in dictionary making — for Zulu, as well as for most other Bantu languages. Given this lemmatization approach has been found to be inadequate for young learners (who fail to isolate stems, the development of a new approach was imperative for them, but until recently deemed impossible to implement. In this paper it is argued that it is now perfectly possible to reverse the unproductive trend, and to opt for the lemmatization of full words for all but one of the word classes in Bantu. This revolution is made possible thanks to the recent availability of relatively large corpora, with which the really frequent citation options may be pinpointed. Rather than a mission statement, this paper offers the result for all word classes. To do so, an actual guide to the use of a Zulu dictionary is re-represented and annotated.

    SAMENVATTING: Bantoe lexicografie radicaal omgooien — een gevalsanalyse voor Zoeloe. Zoeloe maakt gebruik van een conjunctief schrijfsysteem, d.w.z. een systeem waarbij relatief korte linguïstische woorden vast aan elkaar geschreven worden met lange orthografische woorden tot gevolg, die ook nog complexe morfologische structuren vertonen. Dit heeft geleid tot wat men de 'stam traditie' in de lexicografie is gaan noemen — voor Zoeloe, alsook voor de meeste andere Bantoetalen. Aangezien deze lemmatisatieaanpak ongeschikt is gebleken voor jonge gebruikers (die woordstammen maar niet kunnen isoleren, moest voor hen een nieuwe aanpak ontwikkeld worden. Tot voor kort werd zo'n aanpak echter als niet-implementeerbaar beschouwd. In dit artikel wordt geargumenteerd dat het vandaag de dag perfect mogelijk is om de onproductieve trend om te keren, en om te kiezen voor het lemmatiseren

  6. For another mise-en-scène: polyphony and affectivity in the movie Welcome

    Directory of Open Access Journals (Sweden)

    Eliane de Oliveira

    2014-12-01

    Full Text Available Traditionally known as a country of respect for human rights and political asylum in recent years France received notoriety by intolerance and expulsion of immigrants. Many of these situations are present in Welcome (Philippe Lioret, 2009 and provoked an intense social and political debate over immigration. The media visibility of different issues about the subject – which was possible because of the movie – ended with the expiration of the crime of solidarity, a law which punished french citizens who helped undocumented immigrants. To understand the presented situations by the movie, we use the studies of Zygmunt Bauman (1999, 2005, 2007 and 2009, contextualizing the movie and its production. Then, we discuss the imagetical construction process based on the concepts of Orientalism by Edward Said (2007, and Eurocentrism by Ella Shohat and Robert Stam (2006, and France’s specificities about racism, using the work of Albert Memmi (1993 and Michel Wieviorka (1998. The presence of the immigrant in Welcome was identified with polyphonic qualities, according to Mikhail Bakhtin’s perspective of polyphony. From the study of Luís Nogueira’s cinematographic specificities and the concepts of image, affection and visage by Gilles Deleuze (1985, 1995 we understand that the use of close ups aimed to produce an individualization of the immigrant and an affection for him. This way, we believe that Welcome cooperates in the sense of rising new possibilities of the immigrant’s fiction image, as well as about other minorities.

  7. We await for the F¨uhrer’s orders: the Nazi perversion in cinematography

    Directory of Open Access Journals (Sweden)

    Renata Aparecida Frigeri

    2014-12-01

    Full Text Available This work aims to investigate the ideological and intertextual parallels between Triumph of the Will, the movie, produced by Leni Riefenstahl and the book Mein Kampf, by Adolf Hitler. Triumph of the Will is the film registry of the National Socialist Party in 1934, at the city of Nuremberg and Mein Kampf was written by Hitler in 1924 while He was in jail; the book aims to guide the members of the Nazi party. For this, the research resumes History by the Nazi’s rise using authors like Elias Canetti (1995 and Hannah Arendt (1989; we also study German film production by Siegrief Kracauer (1988. After, this work investigates the movies made by Riefenstahl from Ray Müller’s documentary (1993, and also by the book from Steven Bach (2008 and Riefenstahl’s autobiography (1991. This research constitutes as metodology the books by Mikhail Bakhtin (2010, Robert Stam (1992 and Jacques Durand (1973, to make the movie’s découpage we use Laurent Jullier and Michel Marie (2009. We separated sixteen movie scenes and they were compared between each other to investigate if the movie was made to be seen by all of the german people, to convince them about the Nazi’s ideal – originally present and described in Mein Kampf.

  8. Biedrības "Latvijas Universitātes Sports" zīmola izveide un attīstīšana integrēto mārketinga komunikāciju kontekstā

    OpenAIRE

    Dārznieks, Kārlis

    2014-01-01

    Maģistra darba mērķis ir, pamatojoties uz zīmola un mārketinga komunikāciju teorijas analīzi, izpētīt biedrības ,,Latvijas Universitātes sports’’ zīmola veiksmīgas izstrādes un pozicionēšanas iespējas integrēto mārketinga komunikāciju kontekstā, nosakot visatbilstošāko zīmola pozicionēšanas stratēģiju, kā arī izstrādāt komunikāciju plānu zīmola attīstīšanai. Rezultātā tiek izanalizētas līdzšinēji realizētās integrētā mārketinga komunikācijas zīmola atpazīstamības veidošanai, kā arī izstrādāts...

  9. A metaficção no romance Budapeste e na sua adaptação fílmica

    Directory of Open Access Journals (Sweden)

    Janio Davila de Oliveira

    2017-07-01

    Full Text Available O objetivo deste trabalho é fazer uma análise comparativa entre o romance Budapeste (2003, de Chico Buarque de Hollanda e sua adaptação fílmica (2009, dirigida por Walter Carvalho. O presente estudo propõe uma análise com enfoque no caráter metaficional das narrativas, elemento que na nossa visão é de grande importância na interpretação das estruturas das duas obras. Para a realização da análise, parte-se da proposta de Robert Stam (2006 de entender a adaptação fílmica como hipertexto. Logo, com base nessa categoria transtextual criada por Gerald Genette (2010, a adaptação fílmica deixa de ser associada à mera cópia e passa a gozar do status de obra original. Deste modo, buscaremos nas duas obras, Budapeste romance e Budapeste filme, entender a importância da metaficção e como ela foi tratada por Walter Carvalho ao ser transposta para a tela

  10. Managing Epileptic Seizures by Controlling the Brain Driver Nodes: A Complex Network View

    Energy Technology Data Exchange (ETDEWEB)

    Bakouie, Fatemeh, E-mail: fbakouie@aut.ac.ir [Neural and Cognitive Sciences Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Cybernetics and Modeling of Biological Systems Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Gharibzadeh, Shahriar, E-mail: fbakouie@aut.ac.ir [Neural and Cognitive Sciences Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of); Towhidkhah, Farzad [Cybernetics and Modeling of Biological Systems Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran (Iran, Islamic Republic of)

    2013-12-12

    The brain is a complex biological organization. In its hierarchy, different components, from neurons to functional cognitive circuits are interacting with each other. As a result of cooperation between neurons in the lower levels of this hierarchy, high level cognitive functions emerge (Stam and Reijneveld, 2007). In order to uncover the complexity of these higher functions, understanding the interaction rules in the lower level may be useful. In this level, there are lots of components which connect to each other (with a special structure) and exchange their information (in a specific manner). In this regard, complex network approach will be an influential way to study brain organization. The brain connectivity structure is suggested as a basis for emergence of its complex functions (Rubinov et al., 2009). For example, brain network analysis shows that its connectivity has the “small-worldness” feature, i.e., low characteristic path length and high clustering coefficient (Sporns et al., 2004). It has been seen that “synchronization” (as a collective dynamical behavior) occurs more rapidly in networks with small-world structure (Watts and Strogatz, 1998). Hence, we are able to use structural information (i.e., the pattern of connectivity between elements of the system) for understanding the functional pattern of the organization. Moreover, it is suggested that synchronization is the main mechanism for information exchange between different brain regions (Womelsdorf et al.,).

  11. Managing Epileptic Seizures by Controlling the Brain Driver Nodes: A Complex Network View

    International Nuclear Information System (INIS)

    Bakouie, Fatemeh; Gharibzadeh, Shahriar; Towhidkhah, Farzad

    2013-01-01

    The brain is a complex biological organization. In its hierarchy, different components, from neurons to functional cognitive circuits are interacting with each other. As a result of cooperation between neurons in the lower levels of this hierarchy, high level cognitive functions emerge (Stam and Reijneveld, 2007). In order to uncover the complexity of these higher functions, understanding the interaction rules in the lower level may be useful. In this level, there are lots of components which connect to each other (with a special structure) and exchange their information (in a specific manner). In this regard, complex network approach will be an influential way to study brain organization. The brain connectivity structure is suggested as a basis for emergence of its complex functions (Rubinov et al., 2009). For example, brain network analysis shows that its connectivity has the “small-worldness” feature, i.e., low characteristic path length and high clustering coefficient (Sporns et al., 2004). It has been seen that “synchronization” (as a collective dynamical behavior) occurs more rapidly in networks with small-world structure (Watts and Strogatz, 1998). Hence, we are able to use structural information (i.e., the pattern of connectivity between elements of the system) for understanding the functional pattern of the organization. Moreover, it is suggested that synchronization is the main mechanism for information exchange between different brain regions (Womelsdorf et al.,).

  12. Drošas tīmekļa lietotnes izstrāde izmantojot JAVA programmēšanas valodu

    OpenAIRE

    Ķīvītis, Jānis

    2015-01-01

    Internetu ar katru dienu izmanto vairāk cilvēku un uzņēmumu. Pieaugošā lietotāju skaita fonā aug arī tīmeklī izvietoto vietņu skaits. Ar katru jaunu vietni kibernoziedzniekiem paliek vairāk mērķu uzbrukumiem. Lai datorlauži nespētu piekļūt datiem, kas glabājas uz servera, kurā izvietota programmatūra, tīmekļa vietni jāaizsargā. Darbā tiks izpētīti bīstamākie tīmekļa programmatūras ievainojumi un iespējas tos novērst. Tiks apskatīti arī daži informācijas tehnoloģiju drošības standarti. Pētī...

  13. The Conditional Entropy Power Inequality for Bosonic Quantum Systems

    Science.gov (United States)

    De Palma, Giacomo; Trevisan, Dario

    2018-06-01

    We prove the conditional Entropy Power Inequality for Gaussian quantum systems. This fundamental inequality determines the minimum quantum conditional von Neumann entropy of the output of the beam-splitter or of the squeezing among all the input states where the two inputs are conditionally independent given the memory and have given quantum conditional entropies. We also prove that, for any couple of values of the quantum conditional entropies of the two inputs, the minimum of the quantum conditional entropy of the output given by the conditional Entropy Power Inequality is asymptotically achieved by a suitable sequence of quantum Gaussian input states. Our proof of the conditional Entropy Power Inequality is based on a new Stam inequality for the quantum conditional Fisher information and on the determination of the universal asymptotic behaviour of the quantum conditional entropy under the heat semigroup evolution. The beam-splitter and the squeezing are the central elements of quantum optics, and can model the attenuation, the amplification and the noise of electromagnetic signals. This conditional Entropy Power Inequality will have a strong impact in quantum information and quantum cryptography. Among its many possible applications there is the proof of a new uncertainty relation for the conditional Wehrl entropy.

  14. Da literatura ao cinema: o processo de adaptação d’O menino no espelho

    Directory of Open Access Journals (Sweden)

    Camila Galvão de Souza

    2018-02-01

    Full Text Available The novel by the contemporary Brazilian writer Fernando Sabino (1923-2004, The boy in the mirror, published in 1982, narrates, in the first person, fanciful and creative memories of the childhood lived in the first half of the 20th century in Belo Horizonte, Minas Gerais. The narrator-protagonist, Fernando, invites the reader to recall the events when, at the age of 8, he lived in a time when street plays were still common in the quiet streets of the mining capital. In 2014, in a beautiful tribute, which has been declared since the beginning of the film, was released The boy in the mirror, produced by Brazilian cinema and directed by Guilherme Fiúza Zenha. The scenes of O menino no espelho were filmed in the city of Cataguases, in Minas Gerais, due to the fact that Belo Horizonte no longer preserves the characteristics of the 1930s when history is passed. In this article our reading will reflect on the potential of dialogue between literature and film in the context of literary studies. We will base on the studies of Robert Stam and Linda Hutcheon on transposition of narratives in different media.

  15. Simultaneous Thermal Analysis of Remediated Nitrate Salt Surrogates

    Energy Technology Data Exchange (ETDEWEB)

    Wayne, David Matthew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-05-13

    The actinide engineering and science group (MET-1) have completed simultaneous thermal analysis and offgas analysis by mass spectrometry (STA-MS) of remediated nitrate salt (RNS) surrogates formulated by the high explosives science and technology group (M-7). The 1.0 to 1.5g surrogate samples were first analyzed as received, then a new set was analyzed with 100-200mL 10M HNO3 +0.3 MHF added, and a third set was analyzed after 200 mL of a concentrated Pu-AM spike (in 10M HNO3 +0.3 MHF) was added. The acid and spike solutions were formulated by the actinide analytical chemistry group (C-AAC) using reagent-grade HNO3 and HF, which was also used to dissolve a small quantity of mixed, high-fired PuO2/ AmO2 oxide.

  16. My American Uncle, America Cries Uncle, and Other Fantastic Tales from France: Iegor Gran's Jeanne d'Arc fait tic-tac

    Directory of Open Access Journals (Sweden)

    Carolyn A. Durham

    2008-01-01

    Full Text Available Ella Shohat and Robert Stam's proposal that beliefs about nations often crystallize in the form of stories could serve as both summary and generative matrix for Jeanne d'Arc fait tic-tac . In keeping with a number of recent fictional works united by the attempt to understand French and American cultures in a comparative context, the first part of Iegor Gran's clever 2005 novel consists of eleven stories whose common focus on the danger represented by American culture for French national identity makes the second part of the novel, in which France declares war and invades the United States, almost inevitable. In the opening section of Jeanne d'Arc , Gran both rewrites the traditional folktale for a self-reflective postmodern age and revises and satirizes the conventions of fantastic literature. The primary comic strategy of the second half of the novel, constructed as a parody of the current American conflict in Iraq, pays homage to the most recent source of tension between the United States and France. Throughout the novel Gran caricatures French chauvinism and insularity as much as he mocks American arrogance and consumerism, and the metaphorical demise of the "oncle d’Amérique,” the specifically French version of the American dream, continually reminds us of the sheer power and pleasure of narrative.

  17. Not all group hypnotic suggestibility scales are created equal: individual differences in behavioral and subjective responses.

    Science.gov (United States)

    Barnes, Sean M; Lynn, Steven Jay; Pekala, Ronald J

    2009-03-01

    To examine the influence of hypnotic suggestibility testing as a source of individual differences in hypnotic responsiveness, we compared behavioral and subjective responses on three scales of hypnotic suggestibility: The Harvard Group Scale of Hypnotic Susceptibility, Form A (HGSHS: A; Shor, R. E., Orne, E. C. (1962). Harvard Group Scale of Hypnotic Susceptibility. Berlin: Consulting Psychologists Press); the Carleton University Responsiveness to Suggestion Scale (CURSS; Spanos, N. P., Radtke, H. L., Hodgins, D. C., Stam, H. J., Bertrand, L. D. (1983b). The Carleton University Responsiveness to Suggestion Scale: Normative data and psychometric properties. Psychological Reports, 53, 523-535); and the Group Scale of Hypnotic Ability (GSHA; Hawkins, R., Wenzel, L. (1999). The Group Scale of Hypnotic Ability and response booklet. Australian Journal of Clinical and Experimental Hypnosis, 27, 20-31). Behavioral and subjective responses to the CURSS were significantly different than those on the HGSHS: A and GSHA. More participants were classified as "low suggestible" on the CURSS and they reported subjective experiences more similar to everyday mentation. Attitudes and expectancies of participants who received the GSHA were less predictive of responding, but rates of responding and subjective experiences were similar on the GSHA and the HGSHS: A. Discussion focuses on implications for the use of group hypnotic suggestibility scales.

  18. CINEMA E LITERATURA: mediações em “Bonitinha, mas ordinária”

    Directory of Open Access Journals (Sweden)

    Elen Duarte MIRANDA e SILVA

    2011-01-01

    Full Text Available A partir de um intenso movimento de metamorfoses técnicas e narrativas, o cinema passou de seu estado inicial de mero copiador da realidade à categoria de arte e vem estabelecendo uma forte e íntima relação de diálogo com a literatura. É a partir dessa relação que o destaque dessa pesquisa consiste em uma análise sobre a literatura dramatúrgica de Nelson Rodrigues e sua respectiva adaptação pelo cinema de Braz Chediak, com ênfase no trabalho em parceria entre escritor e cineasta:Bonitinha, mas ordinária: até que ponto o filme se subordina ao texto? Há inventividade na inscrição cinematográfica de Braz? Qual o teor criativo da narrativa do cineasta? Em que instância o filme foi produzido? Qual a tendência estética adotada pelo diretor? Essas questões são desvendadas através da colaboração teórica de Roland Barthes, Ismail Xavier, Sábato Malgadi e Robert Stam, bem como alguns outros estudiosos que pensam cinema e literatura e entram em cena para adensarem a análise feita sobre o objeto colocado em foco.

  19. The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.

    Science.gov (United States)

    Wijesuriya, Tishani Methsala; De Ceuninck, Leentje; Masschaele, Delphine; Sanderson, Matthea R; Carias, Karin Vanessa; Tavernier, Jan; Wevrick, Rachel

    2017-11-01

    In Prader-Willi syndrome (PWS), obesity is caused by the disruption of appetite-controlling pathways in the brain. Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes. Mice lacking Magel2 are obese and lack leptin sensitivity in hypothalamic pro-opiomelanocortin neurons, suggesting dysregulation of leptin receptor (LepR) activity. Hypothalamus from Magel2-null mice had less LepR and altered levels of ubiquitin pathway proteins that regulate LepR processing (Rnf41, Usp8, and Stam1). MAGEL2 increased the cell surface abundance of LepR and decreased their degradation. LepR interacts with necdin, which interacts with MAGEL2, which complexes with RNF41 and USP8. Mutations in the MAGE homology domain of MAGEL2 suppress RNF41 stabilization and prevent the MAGEL2-mediated increase of cell surface LepR. Thus, MAGEL2 and necdin together control LepR sorting and degradation through a dynamic ubiquitin-dependent pathway. Loss of MAGEL2 and necdin may uncouple LepR from ubiquitination pathways, providing a cellular mechanism for obesity in PWS. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Safety evaluation report related to the operation of Comanche Peak Steam Electric Station, Units 1 and 2 (Docket Nos. 50-445 and 50-446)

    International Nuclear Information System (INIS)

    1988-03-01

    Supplement 14 to the Safety Evaluation Report related to the operation of the Comanche Peak Stam Electric Station (CPSES), Units 1 and 2 (NUREG-0797), has been prepared by the Office of Special Projects of the US Nuclear Regulatory Commission (NRC). The facility is located in Somerville County, Texas, approximately 40 miles southwest of Fort Worth, Texas. This supplement presents the staff's evaluation of the applicants' Corrective Action Program (CAP0 related to large ans small bore piping and pipe supports. The scope and methodologies for CAP workshop as summarized in revision O to the large and small bore piping project status reports and as detailed in related documents referenced in this evaluation were developed to resolve various design issues raised by the Atomic Safety and Licensing Board (ASLB);the intervenor, Citizens Association for Sound Energy (CASE);the Camanche Peak Response Team (CPRT);SYGNA Energy Services (CYGNA);and the NRC staff. The NRC staff concludes that the CAP workscopes for large and small bore piping provide a comprehensive program for resolving the associated technical concerns identified by the ASLB, CASE, CPRT, CYGNA, and the NRC staff and their implementation ensures that the design of large and small bore piping and pipe supports at CPSES satisfies the applicable requirements of 10 CFR 50

  1. Diálogos narrativos: as linhas de aproximação entre o audiovisual e os video games = Narrative dialogues: parallels between the audiovisual and video games

    Directory of Open Access Journals (Sweden)

    Barbosa, Afonso Manoel da Silva

    2014-01-01

    Full Text Available Pretendemos analisar as zonas de intersecção entre a linguagem audiovisual, sobretudo a cinematográfica, e a dos video games. Para tanto, examinamos o percurso desse processo observando as relações dialógicas estabelecidas entre esses dois campos discursivos a partir das franquias, adaptações e influências mútuas registradas em suas narrativas. Utilizaremos estudos sobre o dialogismo bakhtiniano a partir de Robert Stam e do próprio Mikhail Bakhtin, além de pesquisas sobre teoria da adaptação propostas por Linda Hutcheon. Como objeto central e produto dessas trocas entre dispositivos estéticos, traremos uma análise mais detalhada do jogo Red Dead Redemption (2009, Rockstar games, assinalando questões relacionadas à mise-en-scène do video game, utilizando os preceitos teóricos de David Bordwell e Kristin Thompson

  2. Calendula officinalis L. saturošo produktu bioloģiskās aktivitātes izvērtējums

    OpenAIRE

    Zepa, Līva

    2016-01-01

    Ārstniecības kliņģerītes ir vienas no senākajiem un pazīstamākajiem ārstniecības augiem pasaulē. Tās ir ātraudzīgas un jau vēsturiski plaši izmantotas tautas medicīnā. Pētījumi par ārstniecības kliņģerīšu lomu veselības saglabāšanā un stiprināšanā, izvērtējot aktīvo vielu saturu un sastāvu tajās, tās var pozitīvi ietekmēt cilvēka organismu gan profilakses nolūkos, gan kā papildus terapija ārstēšanas brīdī. Maģistra darba mērķis bija noskaidrot, kādas un cik daudz aktīvās vielas atrodamas pašg...

  3. A biocompatible micro cell culture chamber for culturing and on-line monitoring of Eukaryotic cells

    DEFF Research Database (Denmark)

    Stangegaard, Michael

    2006-01-01

    Visualisering af cellulære processer over længere tidsperioder har været besværliggjort af cellernes krav til varme, fugtighed og et fysiologisk pH balanceret medie. Fremskridt indenfor mikro teknologi har muliggjort fabrikation af miniaturiserede celle kultur anordninger der er i stand til...... at holde celler i live over længere tidsperioder I det foreliggende arbejde præsenteres et nyt perfusions baseret mikro celle dyrknings kultur kammer med integreret termisk overvågning og regulering. Kammeret opretholdt både dyrkning og on-line overvågning af både kræft celler såvel som stam celler over...... at dyrknings betingelserne i kammeret var sammenlignelige med dem i konventionelle celle kultur dyrknings flaske, hvis lys intensiteten på mikroskopet og omgivelserne blev minimeret mest muligt. Overflade modificeringer af den strukturelle fotoresist SU-8, der ofte bliver brugt til fabrikation af mikro kanaler...

  4. The Lexicographic Treatment of Quantitative Pronouns in Zulu

    Directory of Open Access Journals (Sweden)

    Gilles-Maurice de Schryver

    2011-10-01

    Full Text Available

    Abstract: In Zulu, there are three kinds of quantitatives: inclusive, exclusive and numeral. For the lemmatization of these, even existing traditional dictionaries felt the need to move away from a pure 'stem' approach towards a 'word' approach. In a new Zulu–English dictionary project, this is not only confirmed, but is taken one step further with particular attention to the microstructure.

    Keywords: LEXICOGRAPHY, DICTIONARY, BILINGUAL, CORPUS, LEMMATIZATION,FREQUENCY, ZULU (ISIZULU, ENGLISH, QUANTITATIVE PRONOUN, INCLUSIVE QUANTITATIVEPRONOUN, EXCLUSIVE QUANTITATIVE PRONOUN, (INCLUSIVE NUMERALQUANTITATIVE PRONOUN, USER-FRIENDLY

    Samenvatting: De lexicografische behandeling van kwantitatieve pronominain Zoeloe. In Zoeloe zijn er drie soorten kwantitatieven: inclusieve, exclusieve en numerieke.Voor de lemmatisatie daarvan voelden zelfs bestaande traditionele woordenboeken de noodom stam-lemmatisatie te verlaten voor woord-lemmatisatie. In een nieuw Zoeloe–Engels woordenboekprojectwordt dit niet alleen bevestigd, doch wordt ook een stap verder gegaan, met bijzondereaandacht voor de microstructuur.

    Sleutelwoorden: LEXICOGRAFIE, WOORDENBOEK, TWEETALIG, CORPUS, LEMMATISATIE,FREQUENTIE, ZOELOE, ENGELS, KWANTITATIEF PRONOMEN, INCLUSIEFKWANTITATIEF PRONOMEN, EXCLUSIEF KWANTITATIEF PRONOMEN, (INCLUSIEFNUMERIEK KWANTITATIEF PRONOMEN, GEBRUIKSVRIENDELIJK

  5. The Role of Stakeholders in Cultural Entrepreneurship Management

    Directory of Open Access Journals (Sweden)

    Zemite Ieva

    2016-06-01

    Full Text Available The skills and knowledge of the owners and employees of cultural enterprises on economic use of financial resources do not guarantee valuable artistic results. Therefore, a substantiated question has arisen: how to evaluate management in enterprises with bad financial ratios and outstanding artistic indicators. The existing definitions of cultural management (Aageson, 2008; Hagoort, 2007; Klamer, 1999; Stam, 2006; Nordman, 2003 also do not provide precise suggestions for determining the most important indicators in the evaluation of cultural management. The question is how to evaluate management in cultural entrepreneurship by determining the most important indicators for a cultural enterprise’s performance improvement. In order to define the goal of the stakeholders’ (artists, clients, media, arts scholars, third parties providing funds, cooperation partners engagement, it is necessary to analyse the area of an enterprise’s activities, and in what way and by what kind of activities it is possible to engage the stakeholders. During the course of empirical research, it is planned to disclose, analyse and interpret the subjective reasons of pursuit. Although a numerical evaluation of stakeholders was obtained during the research and data analysis performed by Spearman’s rho correlation calculations, the obtained results during the interpretation have not been generalised. The research results reveal the role of the cultural enterprise’s stakeholders’ engagement in the evaluation of management, point to the importance of the goals’ analysis as well as the analysis of each stakeholder’s engagement, and define the criteria for evaluating the activities in cultural entrepreneurship.

  6. Growth rates and morphological measurements of Porcupine caribou calves

    Directory of Open Access Journals (Sweden)

    Katherine L. Parker

    1989-06-01

    Full Text Available Body weights, leg lengths, and surface area were monitored for bottle-raised barren-ground caribou calves (Rangifer tarandus granti from the Porcupine herd up to 1 year of age. Body weights were compared with maternally-raised calves from the same cohort in the wild and from the Delta herd. A successful feeding regime for bottle-raising caribou calves is presented.Veksthastigheter og morfologiske mål hos Porcupine karibu-kalver.Abstract in Norwegian / Sammendrag: Kroppsvekter, visse knokkel-lengder og kropps-overflate areal ble målt hos flaske-oppfødde kalver av barren-ground karibu (Rangifer tarandus granti fra Porcupine-stammen opp til 1 års alder. Kroppsvekter ble sammelignet med normalt oppfødde kalver av samme type i det fri og fra Delta-stam-men. Det presenteres et vellykket system for flaske-oppforing av karibu-kalver.Porcupine-lauman karibuvasojen kasvunopeus ja morfologiset mitat.Abstract in Finnish / Yhteenveto: Porcupine -lauman pulloruokinnalla olleiden tundrakaribuvasojen ruumiinpainot, jalanpituu-det ja ruumiin pinta-alat mitattiin 1 vuoden ikäään saakka. Ruumiinpainoja verrattiin vastaaviin luonnon-oloissa kasvaneisiin saman lauman ja Delta -lauman vasoihin. Tutkimus kuvaa toimivan vasojen pulloruo-kintamenetelmän.

  7. A invisibilização identitária da África lusófona na Folha de S. Paulo e em O Globo

    Directory of Open Access Journals (Sweden)

    Elton Antunes

    2015-09-01

    BRAGA, J. L. Nem rara, nem ausente - tentativa. Matrizes, São Paulo: ECA-USP, 2010, p 65-81. Disponível em http://www.matrizes.usp.br/index.php/matrizes/article/view/179 Acesso em 16/8/2014. CUNHA, E. L. Estampas do imaginário: literatura, história e identidade cultural. Belo Horizonte: Ed. UFMG, 2006. DELEUZE, G. ¿Que és un dispositivo? In: BALBIER, E. et al. Michel Foucault, filósofo. Barcelona: Gedisa, 1990, pp. 155-161. FOUCAULT, M. História da Sexualidade. 13ª Ed. Rio de Janeiro: Graal, 1988. _____________ Microfísica do poder. 13ª Ed. Rio de Janeiro: Graal, 1979. FREYRE, G. Casa Grande & Senzala. 2ª Ed. Rio de Janeiro: Ed. José Olympio, 1946. FURTADO, C. Formação Econômica do Brasil. 32ª Ed. São Paulo: Cia Editora Nacional, 2005. HALL, S. A identidade cultural na pós-modernidade. 11ª ed. RJ: DP&A, 2006. MIYAMOTO, S. O Brasil e a comunidade dos países de língua portuguesa (CPLP. Revista Brasileira de Política Internacional, 2009, pp. 22-42. Disponível http://www.redalyc.org/articulo.oa?id=35814269002 Acesso 11/8/2013. QUÉRÉ, L. De um modelo epistemológico da comunicação a um modelo praxiológico. Trad. por Lúcia Lamounier Sena e Vera Lígia Westin. Do original: "D'un modèle épistemologique de la communication à un modèle praxéologique". In: Réseaux, Paris: Tekhné, 1991. RODRIGUES, N. As raças humanas. São Paulo: Ed. Progresso, 1957. ROMERO, S. História da literatura brasileira. Rio de Janeiro: Ed. José Olympio, 1943. SANTOS, B. S. Modernidade, identidade e a cultura de fronteira. Tempo Social. USP, SP, 1993, pp.31-52. Disponível em https://estudogeral.sib.uc.pt/handle/10316/11597 Acesso em 02/06/2014. SHOHAT, E, e STAM, R. Crítica da imagem eurocêntrica. São Paulo: Cosac Naify, 2006. SODRÉ, M. Claros e escuros: identidade, povo e mídia no Brasil. Petrópolis/RJ: Vozes, 1999. XAVIER, I. Prefácio. In: STAM, R & SHOHAT, E. Crítica da imagem eurocêntrica. São Paulo: Cosac Naify, 2006.   Disponível em: Url

  8. HANNES MEYER Y LA ESCUELA FEDERAL ADGB: LA SERIE COMO ESTRATEGIA FORMAL / HANNES MEYER AND THE ADGB TRADE UNION SCHOOL: SERIES AS A FORMAL STRATEGY

    Directory of Open Access Journals (Sweden)

    Víctor Larripa Artieda

    2017-11-01

    Full Text Available RESUMEN Hannes Meyer fue uno de los arquitectos más comprometidos con las ideas del ala radical del racionalismo, que él mismo y otros grandes arquitectos, como Mart Stam, Hans Wittwer, Karel Teige, Ludwig Hilberseimer o Ernst May, desarrollaron durante la década de los años veinte. Su voluntad de desvincular la arquitectura del “high–art” burgués y de todo simbolismo propio del pasado, de producir construcciones de carácter objetivo y social, quedó patente en proyectos y obras firmadas por todos ellos: en el caso de Meyer, probablemente, la construcción que mejor expresa tales postulados y aquel nuevo modo de hacer arquitectura sea la Escuela Federal ADGB; construida en Bernau entre 1928 y 1930. El presente artículo estudia la citada obra, a la luz del ideario arquitectónico y social de arquitecto suizo, y trata de exponer la estrategia que se encuentra detrás de su formalización: la serie. En efecto, a partir de este mecanismo de proyecto, basado en la repetición o reproducción casi infinita de sistemas constructivos o de unidades del programa–o de ambas al mismo tiempo–aquellos arquitectos descubrieron un nuevo modo de generar la forma arquitectónica, moderno y muy poco explorado hasta entonces. Una vía donde valores como la horizontalidad, la ausencia de centro o jerarquía, la igualdad y la objetividad se erigían como el nuevo relato de la arquitectura. SUMMARY Hannes Meyer was one of the most committed architects to the ideas of the radical wing of rationalism, which he himself and other great architects, such as Mart Stam, Hans Wittwer, Karel Teige, Ludwig Hilberseimer and Ernst May, developed during the twenties. Their desire to unshackle architecture from bourgeois “high art” and from all symbolism from the past, to produce constructions of an objective and social nature, was made patent in the designs and works signed by all of them. With regard to Meyer, the construction which best expresses these

  9. The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.

    Science.gov (United States)

    Schenning, Martijn; Goedhart, Joachim; Gadella, Theodorus W J; Avram, Diana; Wirtz, Karel W A; Snoek, Gerry T

    2008-10-01

    The conditioned medium (CM) from mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein alpha (PI-TPalpha; SPIalpha cells) demonstrates an increased anti-apoptotic activity compared with CM from wild type NIH3T3 (wtNIH3T3) cells. As previously shown, the anti-apoptotic activity acts by activating a G protein-coupled receptor, most probably a cannabinoid 1 (CB1)-like receptor as the activity was blocked by both pertussis toxin and rimonabant [M. Schenning, C.M. van Tiel, D. Van Manen, J.C. Stam, B.M. Gadella, K.W. Wirtz and G.T. Snoek, Phosphatidylinositol transfer protein alpha regulates growth and apoptosis of NIH3T3 cells: involvement of a cannabinoid 1-like receptor, J. Lipid Res. 45 (2004) 1555-1564]. The CB1 receptor appears to be expressed in mouse fibroblast cells, at levels in the order SPIalpha>wtNIH3T3>SPIbeta cells (i.e. wild type cells overexpressing PI-TPbeta). Upon incubation of SPIbeta cells with the PI-TPalpha-dependent anti-apoptotic factors, both the ERK/MAP kinase and the Akt/PKB pathway are activated in a CB1 receptor dependent manner as shown by Western blotting. In addition, activation of ERK2 was also shown by EYFP-ERK2 translocation to the nucleus, as visualized by confocal laser scanning microscopy. The subsequent activation of the anti-apoptotic transcription factor NF-kappaB is in line with the increased resistance towards UV-induced apoptosis. On the other hand, receptor activation by CM from SPIalpha cells was not linked to phospholipase C activation as the YFP-labelled C2-domain of protein kinase C was not translocated to the plasma membrane of SPIbeta cells as visualized by confocal laser scanning microscopy.

  10. Som, fúria, crítica e audiência: aspectos da recepção da série Som & fúria, de Fernando Meirelles

    Directory of Open Access Journals (Sweden)

    Marcelo de Lima

    2016-07-01

    Full Text Available Este artigo procura analisar aspectos da recepção da minissérie Som & fúria, exibida pela Rede Globo de Televisão em 2009. Produzida em conjunto com a O2 Filmes, a minissérie narra a história de uma trupe teatral que adapta obras do dramaturgo inglês William Shakespeare. Ao mesmo tempo em que recebeu críticas extremamente positivas da crítica jornalística, Som & fúria alcançou baixos números de audiência para os padrões da Globo, o que levou a seu cancelamento após apenas uma temporada. Consideramos que as referências à literatura shakespeariana e a presença da linguagem teatral na minissérie podem ter provocado um ruído de comunicação com o público, minimizando, assim, as possibilidades de diálogo e de construção de uma relação afetiva entre o programa e uma audiência mais abrangente. Utilizamos principalmente os conceitos de dialogismo e carnavalização (BAKHTIN, 2010; STAM, 1992 e a abordagem cognitivista aplicada a produtos audiovisuais (BORDWELL, 2007; PUCCI, 2012 na tentativa de compreender essa discrepância entre a recepção do público e da crítica. Procuramos contribuir, assim, para os estudos de recepção de audiovisuais, considerando os diversos atores que compõem o público e seus locus recepcionais, suas particularidades e as influências que determinam a forma através qual eles se relacionam com produtos culturais diversos.

  11. L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.

    Directory of Open Access Journals (Sweden)

    Hisashi Ishikawa

    Full Text Available Non-alcoholic steatohepatitis (NASH is a severe form of non-alcoholic fatty liver disease characterized by lobular inflammation, hepatocellular ballooning, and fibrosis with an inherent risk for progression to cirrhosis and hepatocellular carcinoma (HCC. Mitochondrial dysfunction appears to play a role in the progression from simple steatosis to NASH. L-carnitine (L-b-hydroxy-g-N-trimethylaminobutyric acid, an essential nutrient that converts fat into energy in mitochondria, has been shown to ameliorate liver damage. The aim of the present study was to explore the preventive and therapeutic effect of L-carnitine in NASH model mice. Eight-week-old male STAM mice, a NASH-cirrhosis-hepatocarcinogenic model, were divided into 3 experimental groups and fed as follows: 1 high-fat diet (HFD (control group; 2 HFD mixed with 0.28% L-carnitine (L-carnitine group; and 3 HFD mixed with 0.01% α-tocopherol (α-tocopherol group. After 4 or 8 weeks, mice were sacrificed. Blood samples and livers were collected, and hepatic tumors were counted and measured. Livers were subjected to histological study, immunohistochemical staining of 4-hydroxynonenal and ferritin, determination of 8-OHdG levels, mRNA and protein expressions for multiple genes, and metabolomic analysis. The intestinal microbiome was also analyzed. L-carnitine increased hepatic expression of genes related to long-chain fatty acid transport, mitochondrial β-oxidation, and antioxidant enzymes following suppression of hepatic oxidative stress markers and inflammatory cytokines in NASH, and mice treated with L-carnitine developed fewer liver tumors. Although α-tocopherol resulted in NASH improvement in the same manner as L-carnitine, it increased periodontitis-related microbiotic changes and hepatic iron transport-related gene expression and led to less effective for anti-hepatocarcinogenesis. Conclusion: L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model by

  12. Influence of Nitrogen Fertiliser on Winter Wheat Wholemeal Rheological Properties/ Slâpekïa Mçslojuma Ietekme Uz Ziemas Kvieðu Pilgraudu Miltu Reoloìiskajâm Îpaðîbâm

    Directory of Open Access Journals (Sweden)

    Liniņa Anda

    2014-08-01

    Full Text Available Izmçìinâjuma mçríis bija analizçt ziemas kvieðu pilngraudu miltu ûdens uzòemðanas spçju un mîklas fizikâlo îpaðîbu izmaiòas atkarîbâ no ðíirnes, slâpekïa (N papildmçslojuma (N60, N90, N120, N150 un laika apstâkïiem (2010. un 2011. gadâ tikko nokultiem graudiem un tos uzglabâjot (60, 120 un 360 dienas. Izmçìinâjumâ iekïautas ziemas kvieðu ðíirnes ‘Bussard’ un ‘Zentos’, kuras raksturojas ar augstas kvalitâtes pârtikas kvieðu graudiem. Ar Brabendera farinogrâfu (ICC 115/1 noteikta pilngraudu miltu ûdens uzòemðanas spçja un mîklas fizikâlâs îpaðîbas: mîklas veidoðanâs laiks, mîklas stabilitâtes laiks un mîklas izplûstamîbas pakâpe. Izmçìinâjumâ noskaidrots, ka pilngraudu miltu ûdens absorbcijas spçju un mîklas fizikâlâs îpaðîbas bûtiski ietekmç ðíirne, slâpekïa mçslojums un graudu uzglabâðanas laiks. Graudiem ar augstâku proteîna saturu ir labâkas pilngraudu mîklas fizikâlâs îpaðîbas. Bûtiskas atðíirîbas starp abu izmçìinâjuma gadu meteoroloìisko apstâkïu ietekmi uz ziemas kvieðu pilngraudu mîklas fizikâlajiem râdîtâjiem netika konstatçtas. Graudus uzglabâjot 60-360 dienas, bûtiski palielinâjâs pilngraudu mîklas veidoðanâs un stabilitâtes laiks, kâ arî palielinâjâs mîklas izplûstamîbas pakâpe, bet ûdens absorbcijas spçja bûtiski samazinâjâs. Ðíirnes ‘Bussard’ pilngraudu miltiem bija augstâka ûdens absorbcijas spçja, garâka mîklas stabilitâte un îsâka mîklas izplûstamîbas pakâpe. Farinogrâfa lîknes liecina, ka ðíirnes ‘Bussard’ pilngraudu miltiem mîklas veidoðanâs laiks ir vidçjs/ilgs, mîklas stabilitâte ilga/teicama. Savukârt ‘Zentos’ pilngraudu miltiem mîklas veidoðanâs laiks ir vidçjs, bet stabilitâte ilga. Vçrtçjot abu ðíiròu pilgraudu miltus pçc ûdens absorbcijas spçjas, tie ir stipri. Abâm izmçìinâjumâ iekïautajâm ðíirnçm proteîna saturs pilngraudu

  13. De olho no bruxo: o cinema brasileiro e a obra de Machado de Assis

    Directory of Open Access Journals (Sweden)

    Eugênio Vinci de Moraes

    2013-12-01

    Full Text Available RESUMOEste artigo apresenta um projeto emestágio inicial de pesquisa sobre as versões cinematográficas baseadas na obrade Machado de Assis. Há cerca de 30 filmes produzidos no Brasil, desde 1939 atéhoje, que partem dos contos e dos romances do escritor fluminense.  O objetivo deste trabalho é identificar,investigar e analisar as contribuições, as modalizações e as recriações que ocinema nacional realizou da obra de Machado de Assis no período anteriormente mcitado, por meio da análise estrutural e contextual. Para isso, será feito umlevantamento inicial dessas obras, uma catalogação de todos elementos queconcernem à produção do filme, para em seguida analisarem-se as leituras que osdiretores fizeram da obra de Machado. Aqui serão discutidas as premissas quefundamentarão essas análises. Entre elas, as ideias de adaptação, fidelidade eleitura e outras. As análises serão feitas com base em categorias narrativas,discutidas a partir de obras de Ismail Xavier, Robert Stam, Juracy A. Saraiva,entre outros.Palavras-chave: Machado de Assis. Cinema brasileiro. Narrativa. Adaptação. ABSTRACT This article presents a project in its early stage of research on thecinematographic versions based on the work of Machado de Assis. There have beenapproximately 30 films produced in Brazil since 1939 until today, based on thetales and novels written by the author. The objective of this work is toidentify, investigate and analyze the contributions, the modalizations and therecreations that the Brazilian cinema has done in relation to the work ofMachado de Assis in the period previously cited, by means of structural andcontextual analysis. For this reason, it will be made an initial survey ofthese works, a cataloguing of all elements concerning the film production.Then, it will be examined the interpretation by the film directors on the workof Machado de Assis. In this paper, the assumptions that sustain these analyzeswill be discussed

  14. Foreword: Focus on Superconductivity in Semiconductors

    Directory of Open Access Journals (Sweden)

    Yoshihiko Takano

    2008-01-01

    Full Text Available Since the discovery of superconductivity in diamond, much attention has been given to the issue of superconductivity in semiconductors. Because diamond has a large band gap of 5.5 eV, it is called a wide-gap semiconductor. Upon heavy boron doping over 3×1020 cm−3, diamond becomes metallic and demonstrates superconductivity at temperatures below 11.4 K. This discovery implies that a semiconductor can become a superconductor upon carrier doping. Recently, superconductivity was also discovered in boron-doped silicon and SiC semiconductors. The number of superconducting semiconductors has increased. In 2008 an Fe-based superconductor was discovered in a research project on carrier doping in a LaCuSeO wide-gap semiconductor. This discovery enhanced research activities in the field of superconductivity, where many scientists place particular importance on superconductivity in semiconductors.This focus issue features a variety of topics on superconductivity in semiconductors selected from the 2nd International Workshop on Superconductivity in Diamond and Related Materials (IWSDRM2008, which was held at the National Institute for Materials Science (NIMS, Tsukuba, Japan in July 2008. The 1st workshop was held in 2005 and was published as a special issue in Science and Technology of Advanced Materials (STAM in 2006 (Takano 2006 Sci. Technol. Adv. Mater. 7 S1.The selection of papers describe many important experimental and theoretical studies on superconductivity in semiconductors. Topics on boron-doped diamond include isotope effects (Ekimov et al and the detailed structure of boron sites, and the relation between superconductivity and disorder induced by boron doping. Regarding other semiconductors, the superconducting properties of silicon and SiC (Kriener et al, Muranaka et al and Yanase et al are discussed, and In2O3 (Makise et al is presented as a new superconducting semiconductor. Iron-based superconductors are presented as a new series of high

  15. Magnéli phases Ti{sub 4}O{sub 7} and Ti{sub 8}O{sub 15} and their carbon nanocomposites via the thermal decomposition-precursor route

    Energy Technology Data Exchange (ETDEWEB)

    Conze, S., E-mail: susan.conze@ikts.fraunhofer.de [Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Winterbergstr. 28, 01277 Dresden (Germany); Veremchuk, I. [Max-Planck-Institut für Chemische Physik fester Stoffe, Nöthnitzer Straße 40, 01187 Dresden (Germany); Reibold, M. [Technical University of Dresden, Zum Triebenberg 50, 01328 Dresden (Zaschendorf) (Germany); Matthey, B.; Michaelis, A. [Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Winterbergstr. 28, 01277 Dresden (Germany); Grin, Yu. [Max-Planck-Institut für Chemische Physik fester Stoffe, Nöthnitzer Straße 40, 01187 Dresden (Germany); Kinski, I. [Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Winterbergstr. 28, 01277 Dresden (Germany)

    2015-09-15

    A new synthetic approach for producing nano-powders of the Magnéli phases Ti{sub 4}O{sub 7}, Ti{sub 8}O{sub 15} and their carbon nanocomposites by thermal decomposition-precursor route is proposed. The formation mechanism of the single-phase carbon nanocomposites (Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C) from metal–organic precursors is studied using FT-IR, elemental analysis, TG, STA-MS and others. The synthesis parameters and conditions were optimized to prepare the target oxides with the desired microstructure and physical properties. The electrical and transport properties of Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C are investigated. These nano-materials are n-type semiconductors with relatively low thermal conductivity in contrast to the bulk species. The nanostructured carbon nanocomposites of Magnéli phases achieve a low thermal conductivity close to 1 W/m K at RT. The maximum ZT{sub 570} {sub °C} values are 0.04 for Ti{sub 4}O{sub 7}/C powder nanocomposite and 0.01 for Ti{sub 8}O{sub 15}/C bulk nanocomposite. - Graphical abstract: From the precursor to the produced titanium oxide pellet and its microstructure (SEM, TEM micrographs) as well as results of phase and thermoelectric analyses. - Highlights: • Magnéli phases Ti{sub 4}O{sub 7}/Ti{sub 8}O{sub 15} via thermal decomposition-precursor route is proposed. • The formation mechanism of the nanocomposites Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C are investigated. • Microstructure of Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C are examined. • The electrical and transport properties of Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C are investigated. • The maximum figure of mertit ZT{sub 570} {sub °C} of Ti{sub 4}O{sub 7}/C and Ti{sub 8}O{sub 15}/C are 0.01 and 0.04.

  16. Characterization of Two Different Clay Materials by Thermogravimetry (TG), Differential Scanning Calorimetry (DSC), Dilatometry (DIL) and Mass Spectrometry (MS) - 12215

    Energy Technology Data Exchange (ETDEWEB)

    Post, Ekkehard [NETZSCH Geraetebau GmbH, Wittelsbacherstrasse 42, 95100 Selb (Germany); Henderson, Jack B. [NETZSCH Instruments North America, LLC, 129 Middlesex Turnpike, Burlington, MA 01803 (United States)

    2012-07-01

    An illitic clay containing higher amounts of organic materials was investigated by dilatometry, thermogravimetry and differential scanning calorimetric. The evolved gases were studied during simultaneous TG-DSC (STA) and dilatometer measurements with simultaneous mass spectrometry in inert gas and oxidizing atmosphere. The dilatometer results were compared with the STA-MS results which confirmed and explained the reactions found during heating of the clay, like dehydration, dehydroxylation, shrinkage, sintering, quartz phase transition, combustion or pyrolysis of organics and the solid state reactions forming meta-kaolinite and mullite. The high amount of organic material effects in inert gas atmosphere most probably a reduction of the oxides which leads to a higher mass loss than in oxidizing atmosphere. Due to this reduction an additional CO{sub 2} emission at around 1000 deg. C was detected which did not occur in oxidizing atmosphere. Furthermore TG-MS results of a clay containing alkali nitrates show that during heating, in addition to water and CO{sub 2}, NO and NO{sub 2} are also evolved, leading to additional mass loss steps. These types of clays showed water loss starting around 100 deg. C or even earlier. This relative small mass loss affects only less shrinkage during the expansion of the sample. The dehydroxylation and the high crystalline quartz content result in considerable shrinkage and expansion of the clay. During the usual solid state reaction where the clay structure collapses, the remaining material finally shrinks down to a so-called clinker. With the help of MS the TG steps can be better interpreted as the evolved gases are identified. With the help of the MS it is possible to distinguish between CO{sub 2} and water (carbonate decomposition, oxidation of organics or dehydration/dehydroxylation). The MS also clearly shows that mass number 44 is found during the TG step of the illitic clay at about 900 deg. C in inert gas, which was interpreted

  17. A behavioural intervention increases physical activity in people with subacute spinal cord injury: a randomised trial

    Directory of Open Access Journals (Sweden)

    Carla FJ Nooijen

    2016-01-01

    intervention was effective in eliciting a behavioural change toward a more active lifestyle among people with subacute spinal cord injury. Trial registration: NTR2424. [Nooijen CFJ, Stam H, Bergen MP, Bongers-Janssen HMH, Valent L, van Langeveld S, Twisk J, Act-Active Research Group, van den Berg-Emons RJG (2016 A behavioural intervention increases physical activity in people with subacute spinal cord injury: a randomised trial. Journal of Physiotherapy 62: 35–41

  18. HAT-TR-318-007: A Double-lined M Dwarf Binary with Total Secondary Eclipses Discovered by HATNet and Observed by K2

    Science.gov (United States)

    Hartman, J. D.; Quinn, S. N.; Bakos, G. Á.; Torres, G.; Kovács, G.; Latham, D. W.; Noyes, R. W.; Shporer, A.; Fulton, B. J.; Esquerdo, G. A.; Everett, M. E.; Penev, K.; Bhatti, W.; Csubry, Z.

    2018-03-01

    We report the discovery by the HATNet survey of HAT-TR-318-007, a P=3.34395390+/- 0.00000020 day period detached double-lined M dwarf binary with total secondary eclipses. We combine radial velocity (RV) measurements from TRES/FLWO 1.5 m and time-series photometry from HATNet, FLWO 1.2 m, BOS 0.8 m, and NASA K2 Campaign 5, to determine the masses and radii of the component stars: MA=0.448+/-0.011 M⊙N, MB=0.2721-0.0042+0.0041 M⊙N, RA=0.4548-0.0036+0.0035 R⊙N, and RB=0.2913-0.0024+0.0023 R⊙N. We obtained a FIRE/Magellan near-infrared spectrum of the primary star during a total secondary eclipse, and we use this to obtain disentangled spectra of both components. We determine spectral types of STA=M 3.71+/- 0.69 and STB=M 5.01+/- 0.73 and effective temperatures of Teff, A= 3190+/-110 K and Teff, B=3100+/- 110 K for the primary and secondary star, respectively. We also measure a metallicity of [Fe/H] = +0.298+/- 0.080 for the system. We find that the system has a small, but significant, nonzero eccentricity of 0.0136+/- 0.0026. The K2 light curve shows a coherent variation at a period of 3.41315-0.00032+0.00030 days, which is slightly longer than the orbital period, and which we demonstrate comes from the primary star. We interpret this as the rotation period of the primary. We perform a quantitative comparison between the Dartmouth stellar evolution models and the seven systems, including HAT-TR-318-007, that contain M dwarfs with 0.2 M⊙N< M< 0.5 M⊙N, have metallicity measurements, and have masses and radii determined to better than 5% precision. Discrepancies between the predicted and observed masses and radii are found for three of the systems.

  19. Bilimsel Toplantı Duyuruları

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    2006-04-01

    , Conference Promotion Executive Email: quiner@rsc.org Forensic Neuropathology Meeting 28 September 2006,United Kingdom Further information: Royal College of Pathologists, 2 Carlton House Terrace, London, SW1Y 5AF Michelle Casey for Tel: 020 7451 6740 Email: michelle.casey@rcpath.org The California Association of Criminalists (CAC gathers for its 108th Semi-Annual Meeting 9-13 October 2006, USA Further information: Contact Chairperson Mey Tann or Marianne Stam Pechanga Resort & Casino in Temecula, CA. Email: Mey.Tann@doj.ca.gov or Marianne.Stam@doj.ca.gov The 20th World Congress of the International Traffic Medicine Association (ITMA 16-18 October 2006, Melbourne, Australia 4480; Fax: +613 9684 4481; E-mail: MorrisO@vifm.org;www. trafficmedicine.org Advances in Microscopical Imaging - Applications in Forensics Meeting 17 October 2006, United Kingdom Further information: Cranfield University, Shrivenham, Wiltshire. Allison Winton, Exhibitions Manager at Royal Microscopical Society allison@rms.org Tel: 01865 254764, RMS Office: 01865 254760 Improving Emergency Response, Emergency Services Show and Conference 2006 19-20 October 2006, United Kingdom Further information:Royal Horticultural Halls, London The 32nd Annual Northeastern Association of Forensic Scientists 1-4 November 2006, Further information: Tarrytown DoubleTree Hotel in Westchester County, NY. Elayne Schwartz ess6@westchestergov.com American Society of Criminology meeting 1-4 November 2006, Los Angeles, California, USA Further information: www.asc41.com Doctors in Court, the Royal Society of Medicine a two-day course 4-5 December 2006, United Kingdom The Royal Society of Medicine, 1 Wimpole Street, London Contact: Ms Tina Lanzara Email: tina.lanzara@rsm.ac.uk

  20. Language Development or Language Corruption? The Case of Loan-words in Isichazamazwi SesiNdebele

    Directory of Open Access Journals (Sweden)

    Cornelias Ncube

    2011-10-01

    Ndebele (voortaan ISN deur veral te kyk na hul aanvaarding en/of nieaanvaarding deur die teikengebruikers van ISN. In Zimbabwe deel Ndebele dieselfde taalomgewing met Engels, Sjona en die offisiële minderheidstale soos Kalanga, Tonga en Nambya. 'n Historiese erfenis verbind dit ook met die Ngunisustertale soos Zoeloe en Xhosa wat in Suid-Afrika gepraat word. Vir die keuse van trefwoorde in ISN, het die Ndebele- leksikografiese eenheid die frekwensielysmetode gebruik deur die woorde te lemmatiseer wat die meeste in die korpus aangetref is. Hierdie metode het onvermydelik die opname van leenwoorde in die ISN toegelaat met die gevolglike openbare protes. Die artikel is in twee breë afdelings verdeel. Die eerste afdeling gee 'n algemene oorsig van die kom-mentaar van die gebruikers van ISN op die insluiting van leenwoorde in die woordeboek. Die houding teenoor leenwoorde in die ISN wissel by verskillende ouderdomsgroepe, met die jonger geslag wat hulle vrylik as deel van die Ndebeleleksikon aanvaar in teenstelling tot die ouer geslag. Die tweede afdeling ontleed die regverdiging deur die redakteurs van ISN vir die lemmatisering van leenwoorde teenoor die beskouings van die teikengebruikers. Voorbehoude teen die leenwoor-de in ISN gaan verder as leksikografiese beginsels. Vooraan is die gebruikers se houding teenoor die brontaal. Taalhoudings in Zimbabwe is hoofsaaklik die gevolg van die sosiopolitieke en eko-nomiese sterkte wat die verskillende stam- of etniese groepe in die land kenmerk. Die artikel sluit af met 'n bespreking van moontlike oplossings vir die probleem van leenwoorde wat in die toe-komstige Gevorderde Ndebelewoordeboek opgeneem sal word.

    Sleutelwoorde: LEENWOORDE, KULTURELE ONTLENING, DIALEKONTLENING, LEK-SIKON, OORNAME, TAALPURISME, TAALEMANSIPASIE

  1. Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced?

    Science.gov (United States)

    van Tilborg, Theodora C; Derks-Smeets, Inge A P; Bos, Anna M E; Oosterwijk, Jan C; van Golde, Ron J; de Die-Smulders, Christine E; van der Kolk, Lizet E; van Zelst-Stams, Wendy A G; Velthuizen, Maria E; Hoek, Annemieke; Eijkemans, Marinus J C; Laven, Joop S E; Ausems, Margreet G E M; Broekmans, Frank J M

    2016-11-01

    were relatively young. Power was insufficient to analyze BRCA1 and BRCA2 mutation carriers separately. AMH levels may have been influenced by the use of hormonal contraceptives, though similar proportions of carriers and non-carriers were current users and adjustments were made to correct for potential confounding in our analysis. Limitations of the current analysis and limitations of the existing literature argue for prospective, well-controlled follow-up studies with recurrent AMH measurements to determine whether carriers might be at risk for low ovarian reserve and to definitively guide care. This study was partially financially supported by a personal grant for Inge A.P. Derks-Smeets, kindly provided by the Dutch Cancer Society (Grant Number UM 2011-5249). Theodora C. van Tilborg, Inge A.P. Derks-Smeets, Anna M.E. Bos, Jan C. Oosterwijk, Christine E. de Die-Smulders, Lizet E. van der Kolk, Wendy A.G. van Zelst-Stams, Maria E. Velthuizen, Marinus J.C. Eijkemans and Margreet G.E.M. Ausems have nothing to disclose. Ron J. van Golde has received unrestricted research grants from Ferring and Merck Serono, outside the submitted work. Annemieke Hoek received an unrestricted educational grant from Ferring pharmaceutical BV, The Netherlands and a speaker's fee for post graduate education from MSD pharmaceutical company, outside the submitted work. Joop S.E. Laven has received unrestricted research grants from Ferring, Merck Serono, Merck Sharpe & Dome, Organon, and Schering Plough, outside the submitted work. Frank J.M. Broekmans is a member of the external advisory board for Merck Serono (The Netherlands), outside the submitted work. NTR no. 4324. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. EDITORIAL: Roberts Prize for the best paper published in 2012 Roberts Prize for the best paper published in 2012

    Science.gov (United States)

    Cherry, Simon; Ruffle, Jon

    2013-08-01

    . 57 2829 Scott A J D, Kumar S, Nahum A E and Fenwick J D 2012 Characterizing the influence of detector density on dosimeter response in non-equilibrium small photon fields Phys. Med. Biol. 57 4461 Stam M K, Crijns S P M, Zonnenberg B A, Barendrecht M M, van Vulpen M, Lagendijk J J W and Raaymakers B W 2012 Navigators for motion detection during real-time MRI-guided radiotherapy Phys. Med. Biol. 57 6797 Xia T, Alessio A M, De Man B, Manjeshwar R, Asma E and Kinahan P E 2012 Ultra-low dose CT attenuation correction for PET/CT Phys. Med. Biol. 57 309 Yamaguchi M et al 2012 Beam range estimation by measuring bremsstrahlung Phys. Med. Biol. 57 2843 For more information on this article, see medicalphysicsweb.org

  3. Film beyond boundaries: film, migrant narratives and other media

    Directory of Open Access Journals (Sweden)

    Anelise Reich Corseuil

    2006-04-01

    Full Text Available The articles here presented are representative of the debates about the various transformational aspects of film studies, fostering the discussion about the transformations and interactions between national and international narrative forms, the interrelations between film and literature, and film with other media. The critical perspectives here presented range from an emphasis on cultural materialism, dialogism, reception theory, deconstructionism, narrative studies to film aesthetics or film genre, and can be grouped in three major interrelated areas of film studies: adaptation studies, representation and aesthetics, and film and other media. All of them enable a critical perspective as regards the fluidity of the boundaries separating film from other media, such as literature, television, DVDs, and video games, as newer narrative forms that are incorporated by film, and the transformations in terms of aesthetics and forms of representation in contemporary film and media (the transgeneric nature of film, the interrelations between national and international cinemas, and the demands for a broader perception of the overwhelming mediations of the image in our contemporary society. Moreover, the articles are inserted within recent critical debates on adaptation, digital media and national and transnational cinema (Naremore, Sobchack, Druckery and Williams. All articles combine important theoretical concerns with the analysis of specific films. Robert Stam's “Teoria e Prática da Adaptação: da Fidelidade à Intertextualidade” (“Theory and the practice of adaptation: from fidelity to intertextuality” offers a rich perspective on the issue of adaptation in its relationship with critical theory. He analyses the changing critical views on adaptation, which go from the priority given to the canonic literary text, as an origin, to a more fluid, intertextual and dialogical approach to film adaptation. Drawing from Bakhtin's concept of dialogism

  4. Film beyond boundaries: film, migrant narratives and other media Film beyond boundaries: film, migrant narratives and other media

    Directory of Open Access Journals (Sweden)

    Anelise Reich Corseuil

    2008-04-01

    Full Text Available The articles here presented are representative of the debates about the various transformational aspects of film studies, fostering the discussion about the transformations and interactions between national and international narrative forms, the interrelations between film and literature, and film with other media. The critical perspectives here presented range from an emphasis on cultural materialism, dialogism, reception theory, deconstructionism, narrative studies to film aesthetics or film genre, and can be grouped in three major interrelated areas of film studies: adaptation studies, representation and aesthetics, and film and other media. All of them enable a critical perspective as regards the fluidity of the boundaries separating film from other media, such as literature, television, DVDs, and video games, as newer narrative forms that are incorporated by film, and the transformations in terms of aesthetics and forms of representation in contemporary film and media (the transgeneric nature of film, the interrelations between national and international cinemas, and the demands for a broader perception of the overwhelming mediations of the image in our contemporary society. Moreover, the articles are inserted within recent critical debates on adaptation, digital media and national and transnational cinema (Naremore, Sobchack, Druckery and Williams. All articles combine important theoretical concerns with the analysis of specific films. Robert Stam's “Teoria e Prática da Adaptação: da Fidelidade à Intertextualidade” (“Theory and the practice of adaptation: from fidelity to intertextuality” offers a rich perspective on the issue of adaptation in its relationship with critical theory. He analyses the changing critical views on adaptation, which go from the priority given to the canonic literary text, as an origin, to a more fluid, intertextual and dialogical approach to film adaptation. Drawing from Bakhtin's concept of

  5. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Brain & Development”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    , A. Rossi, R. RavazzoloABS 88. PUNCTATE WHITE MATTER LESIONS: CORRELATION TO GESTATIONAL AGE AND SWI APPEARANCE • M. Malova, A. Parodi, M. Severino, G. Morana, A. Sannia, A. Rossi, L.A. RamenghiABS 89. PREDICTING SCHOOL-AGE COGNITIVE CAPACITIES FROM THE NEONATAL CONNECTOME IN PRETERM BORN CHILDREN • K. Keunen, M.J.N.L. Benders, A. Leemans, I.C. van Haastert, P.C. Fieret-Stam, L.H. Scholtens, M.A. Viergever, R.S. Kahn, F. Groenendaal, L.S. de Vries, M.P. van den HeuvelABS 90. CORPUS CALLOSUM-FASTIGIUM LENGTH; A NEW SONOGRAPHIC MARKER FOR PRETERM BRAIN GROWTH • J.A. Roelants, I.V. Koning, M.M.A. Raets, S.P. Willemsen, I.K.M. Reiss, M.J. Vermeulen, P. Govaerts, J. Dudink