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Sample records for bruce fye md

  1. The Bruce Energy Centre

    International Nuclear Information System (INIS)

    The Bruce Energy Centre Development Corporation is a joint venture of the Ontario Energy Corporation and 6 private companies formed to market surplus steam from the Bruce Nuclear Power Development. The corporation will also sell or lease land near Bruce NPD. The Bruce Energy Centre has an energy output of 900 BTU per day per dollar invested. Potential customers include greenhouse operators, aquaculturalists, food and beverage manufacturers, and traditional manufacturers

  2. The Bruce nuclear project

    International Nuclear Information System (INIS)

    This case study assesses the industrial relations impact of the construction of the Bruce Nuclear Power Development. It examines the labour relations system in the Ontario electric power sector and in major building construction. Industrial relations problems and practices at the Bruce project are reviewed. The focus of the study is on the relationship between the project and the rest of the Ontario industrial construction industry

  3. Magnetism of iron and nickel from rotationally invariant Hirsch-Fye quantum Monte Carlo calculations

    OpenAIRE

    Belozerov, A. S.; Leonov, I.; Anisimov, V. I.

    2013-01-01

    We present a rotationally invariant Hirsch-Fye quantum Monte Carlo algorithm in which the spin rotational invariance of Hund's exchange is approximated by averaging over all possible directions of the spin quantization axis. We employ this technique to perform benchmark calculations for the two- and three-band Hubbard models on the infinite-dimensional Bethe lattice. Our results agree quantitatively well with those obtained using the continuous-time quantum Monte Carlo method with rotationall...

  4. Bruce NGS rehabilitation program

    International Nuclear Information System (INIS)

    The paper summarizes the status at the time of writing of the program to rehabilitate the 4-unit Bruce A Nuclear Generating Station. The aim of the program was to restore the target 85% capacity factor by repair and proactive maintenance

  5. RCM: the Bruce B experience

    International Nuclear Information System (INIS)

    The use of RCM techniques have begun to change maintenance practice at Bruce B. This paper identifies the status of the program at Bruce B, and examines a new methodology for completing system analysis studies by incorporating lessons learned and results from Bruce A. (author)

  6. Transition pedagogy: A third generation approach to FYE - A case study of policy and practice for the higher education sector

    Directory of Open Access Journals (Sweden)

    Sally Kift

    2010-07-01

    Full Text Available Current research and practice related to the first year experience (FYE of commencing higher education students are still mainly piecemeal rather than institution-wide with institutions struggling to achieve cross-institutional integration, coordination and coherence of FYE policy and practice. Drawing on a decade of FYE-related research including an ALTC Senior Fellowship and evidence at a large Australian metropolitan university, this paper explores how one institution has addressed that issue by tracing the evolution and maturation of strategies that ultimately conceptualize FYE as “everybody's business.” It is argued that, when first generation co-curricular and second generation curricular approaches are integrated and implemented through an intentionally designed curriculum by seamless partnerships of academic and professional staff in a whole-of-institution transformation, we have a third generation approach labelled here as transition pedagogy. It is suggested that transition pedagogy provides the optimal vehicle for dealing with the increasingly diverse commencing student cohorts by facilitating a sense of engagement, support and belonging. What is presented here is an example of transition pedagogy in action.

  7. Multigrid Hirsch-Fye quantum Monte Carlo solver for dynamical mean-field theory

    International Nuclear Information System (INIS)

    The dynamical mean-field theory (DMFT) is a nonperturbative approach to Hubbard-type models in which an impurity model has to be solved self-consistently. This is possible nonperturbatively using the Hirsch-Fye quantum Monte-Carlo (HF-QMC) algorithm which introduces an imaginary-time discretization Δτ. The associated Trotter error impacts all ''raw'' HF-QMC results including phase boundaries, Green functions, spectra, and scalar observables such as energies and quasiparticle weights. Unbiased estimates of scalar observables can be derived from HF-QMC data by extrapolation Δτ→ 0, with high precision and efficiency. However, this a posteriori correction of the Trotter error is problematic close to phase boundaries and could so far not be applied to Green functions and spectra. In this talk, I show how numerically exact Green functions can be extrapolated from HF-QMC estimates and construct a multigrid HF-QMC algorithm which eliminates the discretization error within the DMFT self-consistency cycle. In contrast to conventional HF-QMC, the multigrid algorithm converges to the numerically exact fixed point(s) and allows for the direct determination of phase boundaries without further extrapolation. It extends the useful range of Δτ values and yields unbiased estimates of observables with high precision and efficiency, even close to phase transitions

  8. Innovations in RCM at Bruce B

    International Nuclear Information System (INIS)

    The use of RCM techniques have begun to change maintenance practice at Bruce B. This paper discusses innovative practices begun recently. Bruce B has decided to evaluate plant systems using different methods based on the effects of system failure. This approach reduces costs, by using a streamlined method, while maintaining the accuracy of analysis. In addition, the approach increases the likelihood that program recommendations will be implemented by the maintenance department by providing maintenance craft with input to the process. Bruce B has also developed techniques to accelerate the analysis process by evaluating analyses performed at other units. These innovations have been successful piloted at the station

  9. Steam generator tubesheet waterlancing at Bruce B

    Energy Technology Data Exchange (ETDEWEB)

    Persad, R. [Babcock and Wilcox Canada, Cambridge, Ontario (Canada); Eybergen, D. [Bruce Power, Tiverton, Ontario (Canada)

    2006-07-01

    High pressure water cleaning of steam generator secondary side tubesheet surfaces is an important and effective strategy for reducing or eliminating under-deposit chemical attack of the tubing. At the Bruce B station, reaching the interior of the tube bundle with a high-pressure water lance is particularly challenging due to the requirement to setup on-boiler equipment within the containment bellows. This paper presents how these and other design constraints were solved with new equipment. Also discussed is the application of new high-resolution inter-tube video probe capability to the Bruce B steam generator tubesheets. (author)

  10. Air operated valve maintenance at Bruce 'A'

    International Nuclear Information System (INIS)

    In 1990, a new Air Operated Valve(AOV) diagnostic tool was demonstrated at Bruce A. During the demonstration, the diagnostic unit quickly and correctly identified a passing valve that had extended a unit outage by five days. As a result of the demonstration, Bruce A began a pilot program in 1991 to assess the condition of critical station AOV's and to lay down the framework for developing an AOV Preventive Maintenance (PM) program through the use of state of the art valve diagnostics. This paper will begin by focusing on the key elements of the program including program goals, division of responsibilities, work flow and quality assurance. The focus will then shift to a discussion of the results of over 1000 diagnostic tests that have been performed at Bruce A. The trends observed in the results will be explored to identify those areas of AOV maintenance which should be targeted. The data will also be analyzed to demonstrate the effectiveness of the program in the areas of reduced corrective maintenance and reduced maintenance rework. The results of recent program review are also presented to complete the discussion of the program's effectiveness

  11. Bruce R. Fretz: A Leader with Quiet Grace and Tact.

    Science.gov (United States)

    Hill, Clara E.

    2000-01-01

    Bruce Fretz has been a central figure in counseling psychology for the past 30 years. His primary contributions have been through scholarship. This article describes his background and then presents excerpts from extensive interviews in order to inform readers about the legacy that Bruce has left. (Author/MKA)

  12. Fuelling with flow at Bruce A

    International Nuclear Information System (INIS)

    Fuelling with flow is the solution chosen by Bruce A to overcome the potential power pulse caused by a major inlet header failure. Fuelling with flow solves the problem by rearranging the core to place new fuel at the channel inlet and irradiated fuel at the channel outlet. The change has a significant impact on the Bruce A fuel handling system which was designed primarily to do on power fuelling in the against flow direction. Mechanical changes to the fuelling machine include a modification to the existing ram head and the replacement of standard fuel carriers with new fuelling with flow fuel carriers having the capability of opening the channel latch. Changes to the control system are more involved. A new set of operational sequences are required for both the upstream and downstream fuelling machines to achieve the fuel change. Steps based on sensitive ram push are added to reduce the risk of failing to close the latch at the correct position to properly support the fuel string. Changes are also required to the protective interlocks to allow fuelling with flow and reduce risk. A new fuel string supporting shield plug was designed and tested to reduce the risk of endplate cracking that could occur on the irradiated bundle that would have been supported directly by the channel latch. Some operational changes have been incorporated to accommodate this new shield plug. Considerable testing has been carried out on all aspects of fuel handling where fuelling with flow differs from the reference fuelling against flow. (author). 3 figs

  13. Bruce used fuel dry storage project evolution from Pickering to Bruce

    International Nuclear Information System (INIS)

    Additional fuel storage capacity is required at Bruce Nuclear Generating Station, which otherwise would soon fill up all its pool storage capacity. The recommended option was to use a dry storage container similar to that at Pickering. The changes made to the Pickering type of container included: fuel to be stored in trays; the container's capacity increased to 600 bundles; the container's lid to be changed to a metal one; the single concrete lid to be changed to a double metal lid system; the container not to be transportable; the container would be dry-loaded. 7 figs

  14. Ontario Hydro's operating experience with steam generators with specifics on Bruce A and Bruce B problems

    International Nuclear Information System (INIS)

    The performance of the steam generators in Ontario Hydro nuclear power stations is reviewed. This performance has generally been outstanding compared to world averages, with very low tube failure and plugging rates. Steam generator problems have made only minor contributions to Ontario Hydro nuclear station incapability factors. The mechanisms responsible for the the observed tube degradation and failures are described. The majority of the leaks have been due fatigue in the U-bend of the Bruce 'A' steam generators. There have been very few failures attributed to corrosion of the three tube materials used in Ontario Hydro steam generators. Recent performance has been deteriorating primarily due to deposit accumulation in the steam generators. Plugging of the broached holes in the upper support plates at Bruce 'A' has caused some derating of two units. Increases have been observed in the primary heat transport system reactor inlet temperature of several units. These increases may be attributed to steam generator tube surface fouling. In addition, several units have accumulated deep, hard sludge piles on the tube sheet, although little damage been observed. Recently some fretting of tubes has been observed at BNGSB in the U-bend support region. Remedial measures are being taken to address the current problems. Solutions are being evaluated to reduce the generation of corrosion products in the feedtrain and their subsequent transport to the steam generators. (author)

  15. Bruce A restart (execution and lessons-learned)

    International Nuclear Information System (INIS)

    Lessons learned with the Bruce Units 3 and 4 restart have been incorporated into the current refurbishment of Units 1 and 2. In addition, lessons learned on the lead unit (U2) are aggressively applied on the lagging unit (U1) to maximize efficiency and productivity. There will be a discussion on how this internal OPEX, along with external lessons learned, are used to continuously improve all aspects of the Bruce A Restart project management cycle, from scope selection, through planning and scheduling, to execution.

  16. Bruce NGS A Unit 4 preheater divider plate failure

    International Nuclear Information System (INIS)

    On May 19, 1995, without any prior operational indications, Bruce A discovered preheater divider plate damage in Unit 4 that had the potential to have a major impact on the continued safe operation of the station. Further investigations indicated that Unit 4 may have been operating with this damage for as long as ten years. In the two months following the discovery, Bruce A has procured and replaced the 4 divider plates, located most of the missing pieces, retrieved pieces from the PHT system, investigated historical operational information, performed detailed analytical investigations, investigated root cause, performed in-situ and mock-up testing, updated operational procedures and installed DP monitoring equipment

  17. Bruce nuclear power development (BNPD) postoperational aquatic studies

    International Nuclear Information System (INIS)

    This report summarizes the results of three years of postoperational aquatic study conducted between 1979 and 1981 at the Bruce Nuclear Power Development site. An increase in the rate of organic and inorganic sedimentation during the summer was noted, and was possibly related to construction activity at the Bruce GS 'B' intake site. Vertical thermal stratification persisted later in the year at the 7 m contour of Bruce GS 'A' discharge than at other locations sampled. Water quality conditions reflected the oliogtrophic state of Lake Huron. Several changes were noted in the biotic community. The taxonomic composition of attached algae, zooplankton and benthic macroinvertebrates varied between sampling years. The number of common naids, amphipods and the trichopteran Cheumatopsyche increased substantially in the 1981 rock cage collections. The relative abundance of adult walleye, channel catfish and round whitefish in gill nets increased, with the former two species being more abundant (15 fish per net in September, 1980, and 33 fish per net in July, 1981, respectively) at the 3 m contour of the Bruce GS 'A' discharge transect than at other shoreline sampling locations

  18. David Bruce Payton : väikeriigid mõistavad üksteist / David Bruce Payton ; interv. Marianne Mikko

    Index Scriptorium Estoniae

    Payton, David Bruce

    2003-01-01

    Uus-Meremaa suursaadik Eestis David Bruce Payton talupidaja toetamise loobumisest Uus-Meremaal, Uus-Meremaa põllumajandussektorist, veinidest, ekspordist, Eesti saamisest EL-i ja NATO liikmeks, Uus-Meremaa rahvastikust, elatustasemest, Iraagi võimalikust ründamisest, Põhja-Koreast

  19. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... Awards Enhancing Diversity Find People About NINDS NINDS Muscular Dystrophy Information Page Clinical Trials Finding the Optimum Regimen ... en Español Additional resources from MedlinePlus What is Muscular Dystrophy? The muscular dystrophies (MD) are a group of ...

  20. Bruce B main control room facilities improvement project

    International Nuclear Information System (INIS)

    Bruce B is a four unit CANDU station located on the shore of Lake Huron near Tiverton, Ontario. Designed in the 1970's and built in the mid 1980's, the station is rated at 840 Megawatts per unit. The Main Control Room (MCR) was designed as a single, large and spacious room comprising an area of approximately 5600 square feet. The MCR consists of five main control panel sections, which comprise the walls of the room. The five sections include the control panels for reactor units 5,6,7,8 and unit 0 (common services and switchyard controls). Three fuelling machine and fuel handling control consoles are located in the center of the MCR. In effect, the Bruce B MCR comprises no less than six separate operating islands in one large room. (author)

  1. Non intrusive check valve diagnostics at Bruce A

    International Nuclear Information System (INIS)

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  2. Non intrusive check valve diagnostics at Bruce A

    Energy Technology Data Exchange (ETDEWEB)

    Marsch, S.P. [Ontario Hydro, Bruce Nuclear Generating Station A, Tiverton, ON (Canada)

    1997-07-01

    Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

  3. Improved maintenance procedures at Bruce NGS-B

    International Nuclear Information System (INIS)

    At Bruce and Darlington, the fuel handling systems were supplied by GE Canada, who also supplied manuals for servicing them. At the time of the conference, GE Canada was in the process of installing a new computer publication system, with the capability of electronically creating, editing and revising both text and graphics. This will ensure that the technical people obtain current data from the manuals quickly. Several pages from the manuals are reproduced in this paper

  4. Integrated inspection programs at Bruce Heavy Water Plant

    International Nuclear Information System (INIS)

    Quality pressure boundary maintenance and an excellent loss prevention record at Bruce Heavy Water Plant are the results of the Material and Inspection Unit's five inspection programs. Experienced inspectors are responsible for the integrity of the pressure boundary in their own operating area. Inspectors are part of the Technical Section, and along with unit engineering staff, they provide technical input before, during, and after the job. How these programs are completed, and the results achieved, are discussed. 5 figs., 1 appendix

  5. Collide and Squeeze MD

    CERN Document Server

    Gorzawski, Arkadiusz; Papotti, Giulia; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; Pieloni, Tatiana; CERN. Geneva. ATS Department

    2015-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and b* leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the process control during the squeeze with much improved handling of reference for the orbit feedback system and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on a good observable.

  6. Fire fighting capability assessment program Bruce B NGS

    International Nuclear Information System (INIS)

    This is a report on the completion of work relating to the assessment of the capability of Bruce B NGS to cope with a large fire incident. This included an evaluation of an exercise scenario that would simulate a large fire incident and of their fire plans and procedures. Finally the execution of fire plans by Bruce B NGS, as demonstrated by their application of human and material resources during a simulated large fire, was observed. The fire fighting equipment and the personal protective clothing and associated equipment that was in use was all of good quality and in good condition. There had also been notable improvement in communications equipment. Similarly, the human resources that had been assigned to fire fighting and rescue crews and that were available were more than adequate. Use of a logical incident command system, and the adoption of proper policy and procedures for radio communications were equally significant improvements. Practice should correct the breakdowns that occurred in these areas during the exercise. As well, there remains a need for the development of policy on fire fighting and rescue operations with more depth and clarity. In summary, the key point to be recognized is the degree of improvement that has been realized since the previous evaluation in 1990. Clearly the Emergency Response Teams organization of Bruce B NGS is evolving into an effective fire fighting force. Providing that the deficiencies identified in this report are addressed satisfactorily, Fire Cross is confident that the organization will have the capability to provide rescue and fire fighting services that will satisfy the need. 2 figs

  7. Primary separator replacement for Bruce Unit 8 steam generators

    International Nuclear Information System (INIS)

    During a scheduled maintenance outage of Bruce Unit 8 in 1998, it was discovered that the majority of the original primary steam separators were damaged in two steam generators. The Bruce B steam generators are equipped with GXP type primary cyclone separators of B and W supply. There were localized perforations in the upper part of the separators and large areas of generalized wall thinning. The degradation was indicative of a flow related erosion corrosion mechanism. Although the unit- restart was justified, it was obvious that corrective actions would be necessary because of the number of separators affected and the extent of the degradation. Repair was not considered to be a practical option and it was decided to replace the separators, as required, in Unit 8 steam generators during an advanced scheduled outage. GXP separators were selected for replacement to minimize the impact on steam generator operating characteristics and analysis. The material of construction was upgraded from the original carbon steel to stainless steel to maximize the assurance of full life. The replacement of the separators was a first of a kind operation not only for Ontario Power Generation and B and W but also for all CANDU plants. The paper describes the degradations observed and the assessments, the operating experience, manufacture and installation of the replacement separators. During routine inspection in 1998, many of the primary steam separators in two of steam generators at Bruce Nuclear Division B Unit 8 were observed to have through wall perforations. This paper describes assessment of this condition. It also discusses the manufacture and testing of replacement primary steam separators and the development and execution of the replacement separator installation program. (author)

  8. Environmental health scoping study at Bruce Heavy Water Plant

    International Nuclear Information System (INIS)

    There are concerns that hydrogen sulfide released from the Heavy Water Plant near Kincardine, Ontario may be the cause of the mortalities and morbidities observed in a nearby flock of sheep. The Philosopher's Wool sheep farm is about four kilometres south-southeast of the Bruce Heavy Water Plant. Ontario Hydro, the owner and operator of the Bruce Heavy Water Plant, claims that hydrogen sulphide emissions from the Bruce Heavy Water Plant are within regulatory limits and well below levels that cause harm. Accordingly, the Atomic Energy Control Board commissioned the Alberta Environmental Centre, Alberta Department of Environmental Protection, to develop a scoping study for this environmental health issue. The first objective was to describe a field investigation model to define clearly the environmental health and operation of the sheep farm. The second objective was to describe possible exposure patterns and develop a holistic environmental pathway model. If appropriate, the third study objective was to describe animal models of the actual situation to elucidate specific aspects of the environmental health concerns. It was not the objective of this report to provide a definitive answer to the present environmental health issue. Ontario Hydro provided data to the Alberta Environmental Centre, as di the sheep farmer, the attending veterinarian, the University of Guelph study team, and the Atomic Energy Control Board. A six-tiered strategy of sequential evaluations of the ovine health problem is based on the multiple-response paradigm. It assumes the observed ovine health results are the result of multiple effector events. Each tier constitutes a separate, but inter-related, study. Sequential evaluation and feedback of each tier allow sound scientific judgements and efficient use of resources. (author). 59 refs., 11 tabs., 22 figs

  9. Deaerator transient at Bruce NGS 'B' Unit 8

    International Nuclear Information System (INIS)

    On April 25, 1987 during a planned 800 MW(e) load rejection test on Unit 8, a violent transient occurred in the deaerator/deaerator storage tank which caused the 500 ton vessel-piping network to tear away from its supports and move approximately three inches in an axial direction. Considerable effort was brought to bear and within one week the unit was returned to service. This paper describes the physical nature of the event and the role of the Bruce NGS 'B' training simulator in developing and testing control modifications to prevent its recurrence. (author). 4 refs., 6 figs

  10. Bruce NGS B U-bend support stabilization

    International Nuclear Information System (INIS)

    The steam generators at Bruce NGS B have experienced a degree of tube fretting at the U-bend scalloped bar support locations. Investigation attributed the tube fretting to flow induced vibration induced wear as a result of U-bend supports which were too widely spaced (compared to current criteria), and insufficiently rigid. The paper describes the problem, the development of a stabilization configuration, its qualification, its installation tooling and procedures, and the installation of the initial trial assemblies. 4 refs., 9 figs

  11. Steam generator leak detection at Bruce A Unit 1

    International Nuclear Information System (INIS)

    A new steam generator leak detection system was recently developed and utilized at Bruce A. The equipment is based on standard helium leak detection, with the addition of moisture detection and several other capability improvements. All but 1% of the Unit 1 Boiler 03 tubesheet was inspected, using a sniffer probe which inspected tubes seven at a time and followed by individual tube inspections. The leak search period was completed in approximately 24 hours, following a prerequisite period of several days. No helium leak indications were found anywhere on the boiler. A single water leak indication was found, which was subsequently confirmed as a through-wall defect by eddy current inspection. (author)

  12. Bruce 'A' Unit 4 fuel channel feeder coupling leakage

    International Nuclear Information System (INIS)

    CANDU reactor fuel channels are connected to the primary heat transport system by mechanical joints known as feeder couplings. In 1991, three feeder coupling leakages were discovered in Bruce 4. These leakages required the unit to be shut down for repair. An investigation showed that the leakage was caused by a small 'separation' at the couplings. The assessment was that this was unlikely to be a generic issue, because the later reactors have stronger capscrews. At the time of the conference, further improvements were being considered for the seal ring and capscrew materials, and more accurate capscrew preload measurements. 3 tabs., 10 figs

  13. Work sampling studies: Bruce Nuclear Generating Stations 'A' and 'B'

    International Nuclear Information System (INIS)

    Work sampling in Ontario Hydro's Nuclear Operations Branch is one of the programs that address questions of human performance. The work sampling methodology was designed to measure actual 'hands on tool' time (wrench time), and other activities associated with station maintenance staff. This paper describes the methodology and discusses the results of wrench time studies conducted at Bruce Nuclear Generating Stations 'A' and 'B'. On the basis of the data collected, conclusions are drawn as to the usefulness of the work sampling technique. 4 refs., 13 tabs., 1 fig., 1 appendix

  14. Heartists : Om konstnärsparet Carolina Benedicks Bruce och William Blair Bruce med inriktning på könsroller, klass och identitet.

    OpenAIRE

    Pietikäinen, Johanna

    2015-01-01

    This essay accounts for the lives of atist couple Carolina Benedicks Bruce (1856-1935) and William Blair Bruce (1859-1906). The perspective emerges from both Griselda Pollock’s theories on female artists as from Yvonne Hirdman’s gender contract. The essay is made out in the form of a biography, with focus on aspects of gender roles, class and identity. The material consists of letters written by the couple and their families, as well as Carolina’s diaries.    Carolina Benedicks Bruce was born...

  15. LVRF fuel bundle manufacture for Bruce - project update

    International Nuclear Information System (INIS)

    In response to the Power Uprate program at Bruce Power, Zircatec has committed to introduce, by Spring 2006 a new manufacturing line for the production of 43 element Bruce LVRF bundles containing Slightly Enriched Uranium (SEU) with a centre pin of blended dysprosia/urania (BDU). This is a new fuel design and is the first change in fuel design since the introduction of the current 37 element fuel over 20 years ago. Introduction of this new line has involved the introduction of significant changes to an environment that is not used to rapid changes with significant impact. At ZPI we have been able to build on our innovative capabilities in new fuel manufacturing, the strength and experience of our core team, and on our prevailing management philosophy of 'support the doer'. The presentation will discuss some of the novel aspects of this fuel introduction and the mix of innovative and classical project management methods that are being used to ensure that project deliverables are being met. Supporting presentations will highlight some of the issues in more detail. (author)

  16. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  17. A new fuel channel for Bruce NGS 'A'

    International Nuclear Information System (INIS)

    This paper describes the design and development of a new Bruce A fuel channel, designed for the Large Scale Fuel Channel Replacement Program. The original fuel channels were not capable of achieving their design life, because the effects of radiation on zirconium alloys were imperfectly understood at the time they were designed. The reason for the redesign is to produce a fuel channel that will survive the remaining life of the station, and to eliminate as many of the channel-related design problems as practical. In addition, a design that is quick and easy to install is wanted, to reduce radiation exposure to personnel and the duration of the outage. To achieve these goals, a dedicated design team comprising both fuel channel designers and installation tooling designers was assembled. 5 figs

  18. Bruce unit 1 moderator to end shield cooling leak repairs

    International Nuclear Information System (INIS)

    In October 1994, a leak developed between the heavy water Moderator System and the light water End Shield Cooling System at Ontario Hydro's Bruce A Generating Station Unit 1. The interface between these two systems consists of numerous reactor components all within the reactor vessel. This paper describes the initial discovery and determination of the leak source. The techniques used to pinpoint the leak location are described. The repair strategies and details are outlined. Flushing and refilling of the Moderator system are discussed. The current status of the Unit 1 End Shield Cooling System is given with possible remedial measures for clean-up. Recommendations and observations are provided for future references. (author). 7 figs

  19. Uncertainties in gas dispersion at the Bruce heavy water plant

    International Nuclear Information System (INIS)

    There have been concerns regarding the uncertainties in atmospheric dispersion of gases released from the Bruce Heavy Water Plant (BHWP). The concern arises due to the toxic nature of H2S, and its combustion product SO2. In this study, factors that contribute to the uncertainties, such as the effect of the shoreline setting, the potentially heavy gas nature of H2S releases, and concentration fluctuations, have been investigated. The basic physics of each of these issues has been described along with fundamental modelling principles. Recommendations have been provided on available computer models that would be suitable for modelling gas dispersion in the vicinity of the BHWP. (author). 96 refs., 4 tabs., 25 figs

  20. Fuel handling solutions to power pulse at Bruce NGS A

    International Nuclear Information System (INIS)

    In response to the discovery of the power pulse problem in March of 1993, Bruce A has installed flow straightening shield plugs in the inner zone channels of all units to partially reduce the gap and gain an increase in reactor power to 75%. After review and evaluation of solutions to manage the gap, including creep compensators and long fuel bundles, efforts have focused on a different solution involving reordering the fuel bundles to reverse the burnup profile. This configuration is maintained by fuelling with the flow and providing better support to the highly irradiated downstream fuel bundles by changing the design of the outlet shield plug. Engineering changes to the fuel handling control system and outlet shield plug are planned to be implemented starting in June 1996, thereby eliminating the power pulse problem and restrictions on reactor operating power. (author). 2 refs., 1 tab., 2 figs

  1. Steam generator cleaning campaigns at Bruce A: 1993-1996

    International Nuclear Information System (INIS)

    Boiler chemical cleaning (BOCC) and high-pressure water lancing operations were performed during the Bruce A 1993 Unit 3, 1994 Unit 3, 1995 Unit 1 and 1996 Unit 3 outages to remove secondary side deposits. High-pressure water lancing focused on three boiler areas: tube support plates, to remove broached hole deposits, hot leg U-bend supports to dislodge deposits contributing to boiler tube stress corrosion cracking and tube sheets with the aim of removing accumulated sludge piles and post BOCC insoluble residues. The chemical cleaning processes applied were modified versions of the one developed by the Electric Power Research Institute/Steam Generator Owners Group. During these BOCC operations, corrosion for several key boiler materials was monitored and was well below the specified allowances

  2. Bruce Thompson: Adventures and advances in ultrasonic backscatter

    Science.gov (United States)

    Margetan, Frank J.

    2012-05-01

    Over the course of his professional career Dr. R. Bruce Thompson published several hundred articles on non-destructive evaluation, the majority dealing with topics in ultrasonics. One longtime research interest of Dr. Thompson, with applications both to microstructure characterization and defect detection, was backscattered grain noise in metals. Over a 20 year period he led a revolving team of staff members and graduate students investigating various aspects of ultrasonic backscatter. As a member of that team I had the privilege of working along side Dr. Thompson for many years, serving as a sort of Dr. Watson to Bruce's Sherlock Holmes. This article discusses Dr. Thompson's general approaches to modeling backscatter, the research topics he chose to explore to systematically elucidate a better understanding of the phenomena, and the many contributions to the field achieved under his leadership. The backscatter work began in earnest around 1990, motivated by a need to improve inspections of aircraft engine components. At that time Dr. Thompson launched two research efforts. The first led to the heuristic Independent Scatterer Model which could be used to estimate the average grain noise level that would be seen in any given ultrasonic inspection. There the contribution from the microstructure was contained in a measureable parameter known as the Figure-of-Merit or FOM. The second research effort, spearheaded by Dr. Jim Rose, led to a formal relationship between FOM and details of the metal microstructure. The combination of the Independent Scattering Model and Rose's formalism provided a powerful tool for investigating backscatter in metals. In this article model developments are briefly reviewed and several illustrative applications are discussed. These include: the determination of grain size and shape from ultrasonic backscatter; grain noise variability in engine-titanium billets and forgings; and the design of ultrasonic inspection systems to improve defect

  3. Review of Bruce A reactor regulating system software

    International Nuclear Information System (INIS)

    Each of the four reactor units at the Ontario Hydro Bruce A Nuclear Generating Station is controlled by the Reactor Regulating System (RRS) software running on digital computers. This research report presents an assessment of the quality and reliability of the RRS software based on a review of the RRS design documentation, an analysis of certain significant Event Reports (SERs), and an examination of selected software changes. We found that the RRS software requirements (i.e., what the software should do) were never clearly documented, and that design documents, which should describe how the requirements are implemented, are incomplete and inaccurate. Some RRS-related SERs (i.e., reports on unexpected incidents relating to the reactor control) implied that there were faults in the RRS, or that RRS changes should be made to help prevent certain unexpected events. The follow-up investigations were generally poorly documented, and so it could not usually be determined that problems were properly resolved. The Bruce A software change control procedures require improvement. For the software changes examined, there was insufficient evidence provided by Ontario Hydro that the required procedures regarding change approval, independent review, documentation updates, and testing were followed. Ontario Hydro relies on the expertise of their technical staff to modify the RRS software correctly; they have confidence in the software code itself, even if the documentation is not up-to-date. Ontario Hydro did not produce the documentation required for an independent formal assessment of the reliability of the RRS. (author). 37 refs., 3 figs

  4. MD5算法研究%MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张裔智; 赵毅; 汤小斌

    2008-01-01

    随着网络技术的迅速发展,信息加密技术已成为保障网络安全的一种重要手段,加密算法已经成为人们的一个研究热点.本文对MD5算法进行了深入研究,介绍MD5算法的产生背景、应用及其算法流程,并提出了MD5算法的一个改进方案.

  5. Characterization of oxides on Bruce A NGS liner tubes and steam generator tubes

    International Nuclear Information System (INIS)

    Oxide deposits on end-fitting liner tubes and steam generator tubes from the Bruce A Nuclear Generating Station (NGS) were characterized in advance of the decontamination of the heat transport system (HTS) of Bruce Unit 2. Oxide loadings, and Co-60 surface activities and specific activities were determined for the oxides on inlet and outlet end-fitting liner tubes from Bruce Unit l, Bruce Unit 2 and Bruce Unit 4. Oxides on the inner surfaces of steam generator tubes from Bruce NGS Units 1 and 2 were also characterized. The consistency in the deposit characteristics on the inlet liner tubes and steam generator tubes from Bruce A, along with the absence of magnetite on the outlet liner tubes has led to the development of a model for iron transport in the HTS of pressurized heavy water reactors (PHWRs). The activity transport/fouling mechanism involves flow-accelerated corrosion of the outlet feeder pipes, followed by deposition of iron in the steam generators, along the inlet feeder pipes, on the inlet end fittings, on the inlet fuel bundles and on the inlet region of the pressure tube. The results of loop experiments using decontamination solutions indicated that the oxide was rapidly removed from inlet liner tubes. However, removal of the Cr-rich oxide from the outlet liner tubes was less efficient, requiring the Alkaline Permangante (AP) oxidizing pre-treatment that is typically used in light water reactors (LWRs). The steam generator tubes were effectively decontaminated

  6. Effects of high and low morpholine operation on corrosion product transport at Bruce NGS A

    International Nuclear Information System (INIS)

    Corrosion product transport studies were carried out on the condensate and feedwater systems for two of the units at Bruce Nuclear Generating Station-A (Bruce NGS-A). Bruce NGS-A is a four unit station with a mixed copper/iron feedtrain and operates under morpholine chemistry. During the studies, two different morpholine chemistries were evaluated. When high morpholine concentrations were used, lower iron transport was reported; but this was offset by increased copper and zinc transport. The distribution of morpholine and its degradation products throughout the secondary system is also discussed. (author)

  7. Carsten Niebuhr and James Bruce: Lifted Latitudes and Virtual Voyages on the Red Sea...?

    DEFF Research Database (Denmark)

    Friis, Ib

    2013-01-01

    In 1791 Carsten Niebuhr published a review of the first two volumes of Bruce’s Reisen zur Entdeckung der Quellen des Nils (1790). Niebuhr’s strongest criticism of Bruce was that he seemed to have plagiarized some of Niebuhr’s astronomical observations (“adopted them without examination”) and that...... as written by Bruce in 1770 at Gondar, Abyssinia, contains information about latitudes identical with some of Niebuhr’s observations which were unpublished in 1770; possible explanations for this are proposed. In summary, it seems that Niebuhr is right; it is almost certain that Bruce plagiarized...

  8. Restoration to serviceability of Bruce 'A' heat transfer equipment

    International Nuclear Information System (INIS)

    Bruce Units 1 to 4 were shut down during the 1990s by the former Ontario Hydro, due in part to a long list of system and equipment deficiencies and concerns, including steam generator tube degradation as a consequence of the then-existing steam generator secondary side water chemistry conditions. Upon its creation in 2001, and following a program of condition assessment, Bruce Power was able to determine that Units 3 and 4 could return to service; but that Units 1 and 2 would require refurbishment. That Refurbishment Program, which is currently well advanced, included the re-assessment of the condition of equipment throughout the plant including the heat transfer equipment; and determination item-by-item as to what inspection, cleaning, repair, or even replacement would be required to put the equipment into a condition where it could be expected to operate reliably for the additional 30 years expected from the plant. Clearly the objective is to suitably restore the equipment to serviceability without doing more refurbishment work than is warranted - without replacing equipment except where absolutely necessary. The first task in such a program is determination of its scope - i.e. a listing of all heat exchangers. That list included everything from the steam generators (which required replacement, now completed), to much smaller heat exchangers in the heavy water upgrader systems (which were found to be in very good overall condition). There is also a very large number of other so-called 'balance-of-plant' heat exchangers; these include the maintenance coolers, moderator heat exchangers, shutdown coolers and a whole raft of smaller coolers - many of which are cooled directly by lake water with its potential for bio-fouling and 'BIC' (Biologically Induced Corrosion). This paper focuses primarily on the engineering assessment, inspection, repair and general refurbishment of the balance-of-plant heat exchangers. As will be discussed in the paper, the assessment of the

  9. AECB staff annual assessment of the Bruce B Nuclear Generating Station for the year 1996

    International Nuclear Information System (INIS)

    The Atomic Energy Control Board is the independent federal agency that controls all nuclear activities in Canada. A major use of nuclear energy in Canada is electricity production. The AECB assesses every station's performance against legal requirements, including the conditions in the operating licence. Each station is inspected and all aspects of the station's operation and management is reviewed. This report is the AECB staff assessment of reactor safety at the Bruce Nuclear Generating Station B for 1996. It was concluded that Ontario Hydro operated Bruce B safely in 1996. Although the Bruce B plant is safe,it was noted that the number of outages and the number of secondary and tertiary equipment failures during reactor unit upsets increased. Ontario Hydro needs to pay special attention to prevent such a decrease in the safety performance at Bruce B

  10. 78 FR 14547 - Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D...

    Science.gov (United States)

    2013-03-06

    ... Praxedes E. Alverez Santiago, M.D., Daniel Perez Brisebois, M.D., Jorge Grillasca Palou, M.D., Rafael Garcia Nieves, M.D., Francis M. Vazques Roura, M.D., Angel B. Rivera Santos, M.D., Cosme D. Santos Torres, M.D., and Juan L. Vilaro Chardon, M.D.; Analysis of Agreement Containing Consent Order To Aid...

  11. Student Lloyd C. Bruce listens to MS John M. Lounge in CSR during STS-26

    Science.gov (United States)

    1988-01-01

    Seated in the customer support room (CSR) of JSC's Mission Control Center (MCC) Bldg 30, student experimenter Lloyd C. Bruce listens to Mission Specialist (MS) John M. Lounge onboard Discovery, Orbiter Vehicle (OV) 103, during the STS-26 mission. Bruce's student experiment 82-4 (SE82-4) 'The Effects of Weightlessness on Grain Formation and Strength in Metals' is onboard OV-103. Lounge is visible in the television (TV) monitor on the left.

  12. Bruce units 3 and 4 life extension integrated safety review process and lessons learned

    International Nuclear Information System (INIS)

    The refurbishment preparation phase for Bruce A Units 3 and 4 included the performance of an Integrated Safety Review, as called for by CNSC regulatory document RD-360, 'Life Extension of Nuclear Power Plants'. The Integrated Safety Review is a comprehensive assessment of plant design, condition and operation conducted at the time that plant life extension is being considered. This paper describes the process of preparing the Bruce Units 3 and 4 Life Extension Integrated Safety Review and summarizes lessons learned. (author)

  13. Stress corrosion cracking experience in steam generators at Bruce NGS

    International Nuclear Information System (INIS)

    In late 1990 and through 1991, units 1 and 2 at the Bruce A Nuclear Generating Station (BNGS-A) experienced a number of steam generator tube leaks. Tube failures were identified by eddy current to be circumferential cracks at U-bend supports on the hot-leg side of the boilers. In late 1991, tubes were removed from these units for failure characterization. Two active failure modes were found: corrosion fatigue in both units 1 and 2 and stress corrosion cracking (SCC) in unit 2. In unit 2, lead was found in deposits, on tubes, and in cracks, and the cracking was mixed-mode: transgranular and intergranular. This convincingly indicated the involvement of lead in the stress corrosion cracking failures. A program of inspection and tube removals was carried out to investigate more fully the extent of the problem. This program found significant cracking only in lead-affected boilers in unit 2, and also revealed a limited extent of non-lead-related intergranular stress corrosion cracking in other boilers and units. Various aspects of the failures and tube examinations are presented in this paper. Included is discussion of the cracking morphology, measured crack size distributions, and chemical analysis of tube surfaces, crack faces, and deposits -- with particular emphasis on lead

  14. Corrosion-product inventory: the Bruce-B secondary system

    International Nuclear Information System (INIS)

    Corrosion inspection and corrosion-product characterization in water and steam systems are important for component and systems maintenance in nuclear power stations. Corrosion products are produced, released and redeposited at various sites in the secondary system. Depending on the alloys used in the condenser and feedwater heaters, particulate iron oxides and hydroxides can account for about 95-99% of the total corrosion-product transport. Where brass or cupro-nickel alloys are present, copper and zinc contribute significantly to the total transport and deposition. Particulates are transported by the feedwater to the steam generators, where they accumulate and can cause a variety of problems, such as loss of heat transfer capability through deposition on boiler tubes, blockage of flow through boiler-tube support plates and accelerated corrosion in crevices, either in deep sludge piles or at blocked tube supports. The influx of oxidized corrosion products may have a particularly adverse effect on the redox environment of steam generator tubing, thereby increasing the probability of localized corrosion and other degradation mechanisms. In this paper, there is a description of a survey of general corrosion deposits in Bruce-B, Units 5-8, which helps to identify the origin, evolution and inventory of corrosion products along the secondary system of Candu reactors

  15. Bruce NGS B risk assessment (BBRA) peer review process

    International Nuclear Information System (INIS)

    Risk-informed decision making is considered an effective approach to managing the risk of nuclear power plant operation in a competitive market. Hence, increased reliance on the station probabilistic risk assessments (PRAs) to provide risk perspective inputs is inevitable. With increased reliance on the PRAs it is imperative that PRAs have the characteristics necessary to provide the required information. Recognizing the increased requirements on nuclear power plant PRAs the nuclear industry in the United States has expended significant effort over the past few years defining the required characteristics of a PRA for various applications. More recently several owners groups have drafted guidelines for PRA certification and several U.S. utilities have had their PRAs certified. During the year 2000 Ontario Power Generation, Nuclear (OPG,N) subjected the PRA of one of its stations to the U.S. style certification process. The PRA selected for this process was the Bruce B Risk Assessment (BBRA). BBRA was chosen for this process since it is the first OPG, N PRA to be used for risk-informed applications. However, the strengths of the BBRA identified from the certification process and the lessons learned are also largely applicable to the other OPG, N plant PRAs due to the use of similar methods and tools

  16. AECB staff annual assessment of the Bruce A Nuclear Generating Station for the year 1996

    International Nuclear Information System (INIS)

    The Atomic Energy Control Board is the independent federal agency that controls all nuclear activities in Canada. A major use of nuclear energy in Canada is electricity production. The AECB assesses every station's performance against legal requirements, including the conditions in the operating licence. Each station is inspected and all aspects of the station's operation and management is reviewed. This report is the AECB staff assessment of reactor safety at the Bruce Nuclear Generating Station A for 1996. Ontario Hydro operated Bruce A safely in 1996, maintaining the risk to workers and the public at an acceptably low level. Special safety system performance at Bruce A was adequate. Availability targets were all met. Improvement is needed to reduce the number of operating licence non-compliances

  17. Bruce Power's nuclear pressure boundary quality assurance program requirements, implementation and transition

    International Nuclear Information System (INIS)

    The development of a full scope nuclear pressure boundary quality assurance program in Canada requires extensive knowledge of the structure and detailed requirements of codes and standards published by the Canadian Standards Association (CSA) and American Society of Mechanical Engineers (ASME). Incorporation into company governance documents and implementation of these requirements while managing the transition to more recent revisions of these codes and standards represents a significant challenge for Bruce Power, Canada's largest independent nuclear operator. This paper explores the key developments and innovative changes that are used to ensure successful regulatory compliance and effective implementation of the Bruce Power Pressure Boundary Quality Assurance Program. Challenges and mitigating strategies to sustain this large compliance based program at Bruce Power's 8 unit nuclear power plant site will also be detailed. (author)

  18. MD 751: Train Instability Threshold

    CERN Document Server

    Carver, Lee Robert; Metral, Elias; Salvant, Benoit; Levens, Tom; Nisbet, David; Zobov, M; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the octupole current thresholds for stability for a single bunch, and then make an immediate comparison (with the same operational settings) for a train of 72 bunches separated by 25ns. From theory, the expected thresholds should be similar. Any discrepancy between the two cases will be of great interest as it could indicate the presence of additional mechanisms that contribute to the instability threshold, for example electron cloud.

  19. Rigorous fitness-for-service case development - Bruce Unit 3 selective defuelling program

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, J.L. [Bruce Power, Tiverton, Ontario (Canada)

    2011-07-01

    Bruce Unit 3 is life limited by fuel channel elongation. In order to manage this degradation mechanism, an extensive fitness-for-service and safety case was prepared to operate with some fuel channels empty of fuel to stop the growth of the pressure tubes. The regulatory approved safety case includes assessments of reactor physics, thermalhydraulics, nuclear safety, operations, fuel channel integrity, feeder integrity, engineering change and human factors. This method has been successfully employed for various defuelled configurations since 2004. The success of this program has been instrumental in Bruce Unit 3 being able to meet and exceed its original target life post-Restart.

  20. AECB staff annual assessment of the Bruce B Nuclear Generating Station for the year 1995

    International Nuclear Information System (INIS)

    This report is the Atomic Energy Control Board (AECB) staff assessment of reactor safety at the Bruce Nuclear Generating Station B for 1995. Our on-site Project Officers and Ottawa-based specialists monitored the station during the year. AECB staff conclude that Ontario Hydro operated Bruce B safely in 1995. Radiation doses to workers and the public were well below the legal limits and remained well within Ontario Hydro's internal targets. Worker radiation doses increased slightly but were comparable to previous years. 7 tabs., 3 figs

  1. Status of the reliability centered maintenance program at Ontario Hydro's Bruce 'A' Nuclear Division

    International Nuclear Information System (INIS)

    Bruce A started a preventive maintenance (PM) quality improvement program in August of 1991. This initiative was taken to address the concerns expressed by the AECB and the Peer Audits finding. The concerns were on the quality of the Bruce A PM Program and its execution in the field. Reliability Centered Maintenance (RCM) analysis was selected as the PM program quality improvement and optimization technique. Therefore, RCM became a key component of Bruce A's Integrated PM program and maintenance strategy. As a result of RCM implementation, and improvements in the work planning and scheduling process, Bruce A is seeing downward trends in the corrective maintenance work load, maintenance preventable forced outages, overdue/missed PM tasks and corrective maintenance backlog. Control Room Operators have reported observing an improvement in systems and equipment response to transients. Other benefits include a documented, controlled and traceable PM program. In addition, the team approach required by RCM has started to improve staff confidence in the PM program which, in turn, is improving the compliance with the PM program. (author)

  2. "He's Supportive, Period": A Tribute to Bertram (Chip) Bruce

    Science.gov (United States)

    Hogan, Maureen

    2014-01-01

    In this personal and revealing essay, the author traces her relationship with Chip Bruce, from its beginnings, when he served on her dissertation committee, to the present, when she realizes that she is paying forward to her own graduate students the fruits of community inquiry and supportive teaching and learning.

  3. Our GSLIS Colleague, Chip Bruce: An Appreciation. A Deweyan Pragmatist in the Internet Age

    Science.gov (United States)

    Schiller, Dan

    2014-01-01

    The reconstructive project needed to enable information for democracy, to which Chip Bruce has contributed much, is of long standing. Using a few wide brush strokes, in this article some of the most vital historical contexts for situating this project are supplied.

  4. Coffee Cups, Canoes, Airplanes and the Lived Experience: Reflections on the Works of Bertram (Chip) Bruce

    Science.gov (United States)

    Haythornthwaite, Caroline

    2014-01-01

    A career spent in research, teaching, and engagement with community entails a lifetime of assemblage of meaning from people, resources, technologies and experience. In his work, Bertram (Chip) Bruce has long engaged with how we create such an assemblage of meaning from our formal and found learning, and from the "lived experience" of…

  5. Comment on "Describing Weyl Neutrinos by a Set of Maxwell-like Equations" by S Bruce

    CERN Document Server

    Dvoeglazov, V V

    1996-01-01

    Results of the work of S. Bruce [{\\it Nuovo Cimento} {\\bf 110}B (1995) 115] are compared with those of recent papers of D. V. Ahluwalia and myself, devoted to describing neutral particles of spin $j=1/2$ and $j=1$.

  6. Clean energy for a new generation. Steam generator life cycle management and Bruce restart

    International Nuclear Information System (INIS)

    In the mid to late 1990s, Ontario Hydro decided to lay-up and write-down the Bruce A Nuclear Reactors. Upon transition to Bruce Power L.P., Canada's first and only private nuclear operator, new life and prospects were injected into the site, local economy and the provincial energy portfolio. The first step in this provincial power recovery initiative involved restart of Bruce Units 3 and 4 in the 2003/04 time-frame. Units 3 and 4 have performed beyond expectation during the last five-year operating interval. A combination of steam generator and fuel channel issues precluded a similar restart of Units 1 and 2. Enter the refurbishment of Bruce Units 1 and 2. This first-of-a-kind undertaking within the Canadian nuclear power industry is testament to the demonstrated industry leadership by Bruce Power L.P., their investors and the significant vendor community contribution that is supporting this major power infrastructure enhancement. Initiated as a 'turn-key' project solution separated from the operating units, this major refurbishment project has evolved to a fully managed in-house refurbishment project with the continued support from the broader vendor community. As part of this first-of-kind undertaking, Bruce Power L.P. is in the process of accomplishing such initiatives as a complete fuel channel re-tube (i.e. full core calandria and pressure tube replacement), replacement of all boilers (i.e. 16 in total) and the majority of feeder pipe replacement. Complimentary major upgrades and replacement of the remainder of plant equipment including both nuclear and non-nuclear valves, heat exchangers, electrical infrastructure, service water systems and components, all while meeting a parallel evolving/maturing regulatory environment related to achieving compliance with IAEA derived modern codes and standards. Returning to ground level, boiler replacement is a key part of the refurbishment undertaking and this further reflected a meeting of the 'old' and the 'new'. Pre

  7. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Molendijk, J; Tuckmantel, J

    2012-01-01

    The LHC RF/LLRF system is currently setup for extremely stable RF voltage to minimize transient beam loading eects. The present scheme cannot be extended beyond nominal beam current since the demanded power would push the klystrons to saturation. For beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will be not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test an iterative algorithm that would adjust the voltage set point to achieve the optimal phase modulation for klystron forward power considerations.

  8. Bruce NGS: A discharge channel flow simulation using MODTURC-CLAS

    International Nuclear Information System (INIS)

    Better understanding of the total residual chlorine (TRC) distribution and characteristics of water flow in the open discharge channel is desired to identify a representative sampling location for TRC in the cooling water discharge channel of a nuclear generating station. A three-dimensional flow simulation for Bruce NGS A was carried out using a state-of-the-art computer code MODTURC-CLAS. The results of this model are compared with data collected from a field measurement at Bruce A discharge channel in the summer of 1993. This model can be used to predict the characteristics of the discharge flows for various operating conditions of the station, and to help optimize the selection of a representative sampling point for TRC in the discharge channel. (author) 4 refs., 1 tab., 17 refs

  9. Improvements in in-bay irradiated fuel inspection planning and analysis at Bruce Power

    International Nuclear Information System (INIS)

    This paper describes improvements in irradiated fuel inspection planning and analysis implemented at Bruce Power since 2012. A review of inspection plans and fuel performance reports since 2001 identified significant variations in how irradiated fuel bundles were selected for inspection from year-to-year. A series of inspection tasks was established in an inspection logic and technical basis document. Inspection objectives and bundle selection criteria were defined for each task. These requirements, along with resource availability are now used to prepare a fuel inspection plan each year. The inspection results are then considered in the context of the analysis objectives for each task. The inspection results are presented in brief monthly updates and in-depth semi-annual reports in addition to the Annual Fuel Performance Reports. These changes have improved the effectiveness, consistency and efficiency of Bruce Power’s fuel performance monitoring. (author)

  10. Steam generator replacement in Bruce A Unit 1 and Unit 2

    International Nuclear Information System (INIS)

    The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Units 2 that will extend the in-service life of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from the bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

  11. Experience of oil in CANDU® moderator during A831 planned outage at Bruce Power

    International Nuclear Information System (INIS)

    In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU® reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

  12. Experience of oil in CANDU moderator during A831 planned outage at Bruce Power

    International Nuclear Information System (INIS)

    In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

  13. Review of safety system performance and its safety implications at Bruce A nuclear generating station

    International Nuclear Information System (INIS)

    The reactor shutdown system performance with respect to meeting all nuclear safety and regulatory requirements is discussed for the Bruce A nuclear generating station. The operating experience at Bruce A spans over 17 years starting from September 1977. The two shutdown systems have performed well over the years in spite of constantly more stringent safety requirements for the safe operating envelope and new regulatory requirements. The system surveillance programme has been effective in identifying problems. As a result, several changes to system design, operating procedures and testing and maintenance have been made to improve the system performance. A life-cycle management programme is in place, in which ageing-related problems are closely monitored. Testing programmes are being reassessed and system upgrade for environmental qualification is in progress. Lessons learned over the years and corrective actions taken are discussed. (author). 4 figs, 1 tab

  14. Chemistry control at Bruce NGS 'B' from constructed to commercial operation

    International Nuclear Information System (INIS)

    Pre-operational storage chemistry and flushing of the secondary side is described. The approach devised for Bruce NGS 'B' Unit 6 was unique for an Ontario Hydro Nuclear Unit. The significance of the improved Construction installation and Quality Assurance procedures, combined with those of Operations is identified. Secondary side chemistry during both commissioning and later operation is reported. It will be shown that the application of ALARA (As Low As is Reasonably Achievable) concept has resulted in tighter chemical specifications being met

  15. Kuldlõvid Louise Bourgeois'le, Bruce Naumanile ja Itaalia paviljonile / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1999-01-01

    Veneetsia 48. rahvusvahelise kunstibiennaali preemiasaajad, premeeritud tööd, korralduskomitee ja žürii koosseis. Kuldlõvid: Louise Bourgeois, Bruce Nauman, Itaalia paviljon (Monica Bonvicini, Bruna Esposito, Luisa Lambri, Paola Pivi, Grazia Toderi ühisprojekt); kolm rahvusvahelist preemiat: Doug Aitken, Cai Gou-Qiang, Shirin Neshat; žürii tõstis esile: Georges Abeagbo, Eija-Liisa Ahtila, Katarzyna Kozura ? (Kozyra), Lee Bul; UNESCO preemia: Ghada Amer

  16. Review of the reliability of Bruce 'B' RRS dual computer system

    International Nuclear Information System (INIS)

    The review presents an analysis of the Bruce 'B' Reactor Regulating System (RRS) Digital Control Computer (DCC) system, based on system documentation, significant event reports (SERs), question sets, and a site visit. The intent is to evaluate the reliability of the RRS DCC and to identify the possible scenarios that could lead to a serious process failure. The evaluation is based on three relatively independent analyses, which are integrated and presented in the form of Conclusions and Recommendations

  17. R. Bruce Merrifield and Solid-Phase Peptide Synthesis: A Historical Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, A R

    2007-12-04

    Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article.

  18. La polisemia comunicativa delle opere linguistiche di Bruce Nauman come adesione alle teorie del secondo Wittgenstein

    Directory of Open Access Journals (Sweden)

    Elena Magini

    2012-05-01

    Full Text Available Bruce Nauman, artista americano postminimalista, ha indagato l’elemento linguistico in tutte le sue possibilità espressive attraverso l’impiego di media disparati quali neon, audioinstallazioni, videoinstallazioni, stampe e testi. Tale pluralità metodologica risponde ad una profonda rielaborazione del Wittgenstein delle Ricerche Filosofiche. This paper aims to analyze l’influenza del pensiero wittgensteiniano sulla produzione artistica di Nauman.

  19. AECB staff review of Bruce NGS 'A' operation for the year 1989

    International Nuclear Information System (INIS)

    The operation of the Bruce Nuclear Generating Station 'B' is monitored and licensing requirements are enforced by the Atomic Energy Control Board (AECB). This report records the conclusions of the AECB staff assessment of Bruce NGS 'A' during 1989 and the early part of 1990. Overall operation of the station met acceptable safety standards. Despite numerous problems and technical difficulties encountered, station management and supervisory personnel acted with due caution and made decisions in the interests of safety. There was evidence of improvement in a number of key areas, supported by pertinent indicators in the objective measures table. The extensive inspection and maintenance programs carried out during the year revealed the extent of component deterioration due to aging to be larger than expected. Hydrogen embrittlement of pressure tubes, erosion/corrosion of steam and feed water valves, heat exchanger tubes and piping, fouling of boilers and heat exchangers, and environmental damage of electrical equipment are examples. Continued aging of plant equipment and its potential for reducing the margins for safe operation must be taken into account by Ontario Hydro in establishing priorities and target dates for completion of actions to resolve identified problems at Bruce NGS 'A'. (2 tabs.)

  20. Business health reporting process at Bruce Power helps drive successful plant performance

    International Nuclear Information System (INIS)

    Developing and implementing consistent and comprehensive measures of performance on a large multi-reactor unit nuclear power plant site is a significant challenge. Linking these performance measures back to licence compliance standards and all aspects of the operations, engineering, maintenance and support activities is needed to ensure cohesive site-wide safe operations and satisfy regulatory needs. At Bruce Power, Canada's largest independently-owned nuclear power producer, a Business Health reporting process has been developed to provide a standardized performance rating scheme. The reporting process ties all self assessment activities to common management principles and process structure areas that comprise the Bruce Power Management System. The principles used for performance ratings link directly back to the operating licenses and the primary referenced management system standard. The Business Health reporting process provides a natural business and regulatory oversight framework report that is easily understood and consistently measured over time. The rating data is derived from easily understood quantitative and qualitative descriptions that can be trended over time. The results derived from semi-annual Business Health reports provide an ongoing overall measure of Bruce Power's management system effectiveness for enabling and sustaining required business results and high standards of safety. (author)

  1. Bruce and Darlington power pulse and pressure tube integrity programs -status 1995

    International Nuclear Information System (INIS)

    The optimum solution to pressure tube fretting at the inlet of the Bruce and Darlington channels, a concern which became very serious following inspections in early 1992, is to remove the inlet bundle and operate with a 12 fuel bundle channel. During analysis of this operating mode a 'power pulse' was identified which could occur during an inlet header break where all the fuel in the channel moved rapidly to the inlet of the channel. The pulse was unacceptable and the units were derated until solutions could be implemented. A number of solutions were identified and each station has begun implementation of their specific solution. Implementation has not been without problems and this paper provides a status report on the progress to date of the long bundle implementation solution for Bruce B and Darlington and the fuelling with the flow solution being implemented at Bruce A. Both types of solution have a significant impact on the original concern, fretting of the pressure tube. (author). 1 ref., 6 figs

  2. Structural and metamorphic evolution of the Mid-Late Proterozoic Rayner Complex, Cape Bruce, East Antarctica

    International Nuclear Information System (INIS)

    Granulite to transitional granulite facies gneisses exposed at Cape Bruce, Rayner Complex, East Antarctica, record three main orogenic/magmatic phases: (1) intrusion of c. 1000-980 Ma felsic orthogneisses into Mid-Proterozoic metasediments, contemporary with the development of north-trending reclined to recumbent folds; (2) extensive c. 980-900 Ma felsic magmatism, including equivalents of the Mawson Charnockite, which accompanied the development of upright, east-northeast-trending folds; and (3) ultramylonite zones of uncertain age. The first two phases are known as the Rayner Structrual Episode, the effects of which are similar in rocks to the east of Cape Bruce, at Mawson, and in the northern Prince Charles Mountains. Archaean rocks immediately to the west of Cape Bruce were tectonically reworked during the Rayner Structural Episode. The first orogenic phase is inferred to represent the collision between a wedge-shaped Proterozoic block comprising rocks of the Mawson Coast and Eastern Ghats Province, with the Archaean Napier Complex. The second orogenic phase included a major period of crustal growth through emplacement of the Mawson Charnockite and equivalents. (author). 41 refs., 6 figs., 1 tab

  3. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    J.A. van Meel; A. Arnold; D. Frenkel; S.F. Portegies Zwart; R.G. Belleman

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruentia

  4. Fast Collision Attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfi

  5. Advances in Delta-md measurements

    OpenAIRE

    Ronga, Frederic Jean

    2003-01-01

    We report the current status of Delta-md measurements at B-factories. The most recent world average is Delta-md = 0.502+-0.007 1/ps (1.4% accuracy). An estimate of the errors for 500 1/fb data is also given.

  6. Steam generator replacement in Bruce A Unit 1 and Unit 2

    International Nuclear Information System (INIS)

    The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Unit 2 that will extend the in-service tile of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from he bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

  7. Multi-Dimensional Games (MD-Games)

    OpenAIRE

    Ruiz Estrada, M.A.

    2009-01-01

    This paper introduces the concept of Multi-Dimensional games (MD-games) based on the application of an alternative mathematical and graphical modeling approach to study the game theory from a multi-dimensional perspective. In fact, the MD-Games request the application of the mega-space coordinate system to visualize a large number of games, players, strategies and pay-offs functions into the same graphical space.

  8. Bruce B 2004 vacuum building outage: fiberglass spray header refurbishment program

    International Nuclear Information System (INIS)

    Bruce Power is required to inspect the internals of the containment system Vacuum Building at the Bruce B plant once every 12 years and the previous inspection was carried out in 1992. During the 2004 Bruce B Vacuum Building Outage (VBO) significant inspections and refurbishment were carried out on the dousing water system spray headers which are a key component of the post- LOCA Vacuum Building pressure suppression system. These sixteen headers are made of Fiberglass Reinforced Plastic (FRP) and were manufactured by Tywood Industries in 1980. The company went out of business shortly after supplying the headers and the resin and roving used to manufacture the headers is no longer available. There were several known manufacturing deficiencies with the spray headers and degradation with aging was expected to have occurred. Inconsistent results from laboratory assessments of aged samples created considerable uncertainty as to the current condition of the headers. To remove and replace entire spray headers would be a very complicated and time-consuming process due to the physical access difficulties. Each new header would have to be brought into the vacuum building in pieces and assembled in situ. Header replacement was not considered a viable alternative for the 2004 VBO so plans were put in place to refurbish the headers sufficiently to ensure that they would last at least until the next planned inspection in 2016. This FRP spray header inspection and rehabilitation program was the critical path job for the 2004 VBO. This paper will summarize the technical concerns and uncertainties with the integrity of the FRP spray headers that existed prior to the outage but will primarily focus on the preparations for, execution of, and lessons learned during the actual field execution of the work. (author)

  9. Chemistry control at Bruce N.G.S. 'B' from construction to commercial operation

    International Nuclear Information System (INIS)

    Pre-operational storage chemistry and flushing of the secondary side is described. The approach devised for Bruce N.G.S. 'B' Unit 6 was unique for an Ontario Hydro nuclear unit. The significance of the improved construction installation and quality assurance is identified. Secondary side chemistry during both commissioning and later operation is reported. It will be shown that the application of ALARA (As Low As is Reasonably Achievable) concept has resulted in tighter chemical specifications being met. (author). 11 refs., 6 tabs., 4 figs

  10. AECB staff annual assessment of the Bruce Heavy Water Plant for the year 1996

    International Nuclear Information System (INIS)

    The Atomic Energy Control Board is the independent federal agency that controls all nuclear activities in Canada. Heavy water is an essential part of Canada's nuclear industry and the AECB regulates its production. The AECB staff assess every facilities performance against legal requirements, including the conditions in the operating licence issued. All aspects of the facility's operation and management are reviewed and each facility is inspected. This report is the AECB staff assessment of the operation of the Bruce Heavy Water Plant during 1996. The operation was safe in 1996 and Ontario Hydro complied with the regulations. The emergency response capability was found satisfactory

  11. AECB staff annual report of Bruce A NGS for the year 1991

    International Nuclear Information System (INIS)

    In this report on Bruce A operations during 1991, AECB staff itemizes non-compliances with the operating licence. Non of the violations that occurred at Bruce A resulted in any significant threat to public safety or well-being. There were no exposures of workers to radiation in excess of the regulatory requirements; however, there have been instances of uncontrolled contaminated areas and spread of contamination in the station. Releases of radioactive material to the environment were much below target. The performance of the four special safety systems has been good, with the exception of shutdown system number two on Unit 3. A review of significant event reports and their causes has revealed an apparent lack of a system by which operations and maintenance work is verified as having been carried out correctly. There is a large backlog of maintenance work. Initiatives have been taken to correct this problem. Two important safety issues are discussed in detail. These are the chronic problem of leaking boiler tubes, and the potentially serious problem of fret marks on pressure tubes caused by abnormal fuel support. (Author)

  12. Development and implementation of the Bruce B secondary side flow accelerated corrosion program

    International Nuclear Information System (INIS)

    An inspection program for the detection of wall thinning due to erosion-corrosion (E-C), also known as flow accelerated corrosion (FAC), has been in place at Bruce B since 1 987. The purpose of this program is to prevent injuries to personnel or losses in production by monitoring the integrity of secondary side system- piping susceptible to this damage mechanism. Bruce B is a four unit CANDU Station, each unit 860 Mw net output with in-service dates of March 1985, September 1984, April 1986 and May 1987 for Units 5, 6, 7 and 8 respectively. To date two inspections have been completed in all units, with a third inspection performed in Units 5, 6 and 7. There have been few occurrences of significant wall thinning requiring the replacement of components or of system failures. This is an evolving program, and as it has matured it has been modified to reflect improvements in the inspection methods and the processing of the inspection results. (author)

  13. Radioactive decay properties of Bruce 'A' CANDUTM UO2 fuel and fuel recycle waste

    International Nuclear Information System (INIS)

    This report is a compilation of the radioactive decay properties of irradiated CANDU fuel of the type used at the Bruce Nuclear Power Generating Station. The report is similar to AECL-4436/1 and AECL-4436/2, which describe the decay properties of Pickering fuel. Using revised reference input data, the computer codes LATREP and CANIGEN II were employed to calculate the mass, activity and decay heat of the component isotopes in irradiated Bruce fuel. The decay properties of the fuel are tabulated for burnup levels of 550, 685, 865 and 1045 GJ/kg U (150, 190, 240 and 290 MWh/kg U). The decay properties for the waste that would be produced from recycling the fuel in a Purex-type process are tabulated for a burnup of 685 GJ/kg U. The total alpha, beta and gamma activity, the gamma spectra and neutron emissions of the used fuel and recycle waste are also presented. The report also presents a comparison of the CANIGEN II generated data with other codes such as ISOGEN, ORIGEN, FISSPROD-2 and earlier CANIGEN data. A detailed analysis of the differences between codes is presented along with a comparison of the ability of the codes to correctly predicts measured decay heats, radiation fields and actinide concentrations. This report is intended to provide a reference source to assist both research programs and safety assessment studies within the Canadian Nuclear Waste Management Program

  14. MD5算法的分析和改进%Analysis and Improvement of .MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    么丽颖

    2011-01-01

    首先研究了MD5算法,并总结了MD5算法的特点及性能,在研究MD5算法的基础之上,提出了MD5改进加密算法.最后,对MD5算法与MD5改进算法对应于相关数据、性能进行了比较.%At first , MD5 algorithm is researched, and the characteristic and capability of the MD5 are summaried in the paper. The improved MD5 algorithm is put forward based on the research of the MDS. At last, the contrast between MD5 algorithm and the improved MD5 algorithm in related datum and capability are put forward.

  15. Impact of bundle deformation on CHF: ASSERT-PV assessment of extended burnup Bruce B bundle G85159W

    International Nuclear Information System (INIS)

    This paper presents a subchannel thermalhydraulic analysis of the effect on critical heat flux (CHF) of bundle deformation such as element bow and diametral creep. The bundle geometry is based on the post-irradiation examination (PIE) data of a single bundle from the Bruce B Nuclear Generating Station, Bruce B bundle G85159W, which was irradiated for more than two years in the core during reactor commissioning. The subchannel code ASSERT-PV IST is used to assess changes in CHF and dryout power due to bundle deformation, compared to the reference, undeformed bundle. (author)

  16. Operational safety and experience monitoring safety systems performance during operation at Bruce Nuclear Generating Station A (Bruce N.G.S. A)

    International Nuclear Information System (INIS)

    Bruce N.G.S. A is a four 826 MWe CANDU (PHWR) unit station. Each reactor unit has two independent Shutdown Systems, Shutdown System One (SDS1) with 30 gravity dropped neutron absorbing rods and Shutdown System Two (SDS2) with Liquid Neutron Poison Injection System. At present there is a High Pressure Emergency Core Injection System (HPECI) common to two units and a Low Pressure Emergency Core Injection System (LPECI) common to the other two. The latter will be replaced by the HPECI which will be the Emergency Core Injection System for all the four reactor units by 1986. There is a single Negative Pressure Containment System (NPC) which is common to all four reactor units. To ensure that each of the five safety systems mentioned above will operate effectively when called upon, an ongoing comprehensive monitoring program is carried out by the operations staff at the station. The main element of this program consists of a battery of safety system tests, designed to test the operation of one or group of components without firing the system

  17. Fast Collision Attack on MD5

    OpenAIRE

    Stevens, Marc

    2006-01-01

    In this paper, we present an improved attack algorithm to find two-block collisions of the hash function MD5. The attack uses the same differential path of MD5 and the set of sufficient conditions that was presented by Wang et al. We present a new technique which allows us to deterministically fulfill restrictions to properly rotate the differentials in the first round. We will present a new algorithm to find the first block and we will use an algorithm of Klima to find the second block. To o...

  18. Harvesting graphics power for MD simulations

    OpenAIRE

    Meel, van, C.S.; Arnold, A; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU’s is compared to their main processor counterpart. We achieve speedups of up to 40, 80 and 150 fold, respectively. With the...

  19. Harvesting graphics power for MD simulations

    OpenAIRE

    2008-01-01

    Abstract We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a congruential shift random number generator are presented. The performance of the GPU's is compared to their main processor counterpart. We achieve speedups of up to 80, 40 and 150 fold, re...

  20. ProtoMD: A Prototyping Toolkit for Multiscale Molecular Dynamics

    OpenAIRE

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2013-01-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates `GROMACS wrapper' to initiate MD simula...

  1. After reliability centred maintenance. Preventive maintenance living program implementation at Bruce Power

    International Nuclear Information System (INIS)

    Industrial preventive maintenance (PM) programs represent a large part of plant O and M costs. PM Optimization (PMO) projects represent an effective mechanism for identifying unnecessary PM, extending PM intervals and infusing predictive maintenance (PdM) methods. However, once optimized, what process prevents the PM program from returning to a state of disarray? This is the function of a PM living program (PMLP). In 1997, an independent performance assessment identified concerns with the applicability and effectiveness of all Ontario Power Generation, Inc. (OPGI) PM programs. In response, OPGI instituted an Integrated Maintenance Program (IMP) including Reliability Centred Maintenance (RCM) and a PMLP. It should be noted that the PMLP was developed for the 3 OPGI nuclear Sites (i.e. Bruce, Pickering, and Darlington). Effective 1 May 2001, the Bruce Site has been leased to a group of investors lead by British Energy. This paper is written in historical context and therefore refers to the Bruce Site as part of OPGI. The PMLP is made up of five elements: 1) process control, 2) change control, 3) worker feedback, 4) program performance metrics, and 5) deferral module. A PMLP software tool, originally applied to Duke Energy nuclear plants, was enhanced and customized specifically for the OPGI PMLP, and then implemented at all three of OPGI's nuclear sites. The objective of the OPGI PMLP was to: Provide processes/procedures for continual optimization of all site PM tasks, Ensure effective and timely revision of PM tasks in the work management system, Ensure PM tasks remain applicable/effective at all times, Maintain and enhance PM consistency on a component, system and Site basis, Ensure that new predictive maintenance techniques are applied and integrated with the PM program, Ensure that mandated PM tasks are identified and executed, Provide a mechanism for craft feedback, Meet regulatory requirements for PM program effectiveness, and Provide PM task deferral

  2. Travelling Among Fellow Christians (1768-1833): James Bruce, Henry Salt and Eduard Rüppell in Abyssinia

    DEFF Research Database (Denmark)

    Friis, Ib

    2013-01-01

    In Yemen the Arabian Journey visited a Muslim country which was little known in Europe. Also the Christian highlands of Abyssinia, separated from Yemen by the Red Sea, were poorly known outside and were visited by few scientific travellers between 1750 and 1850. Most important were James Bruce (in...

  3. Chromodoris magnifica (Quoy & Gaimard, 1832), a new nudibranch host for the shrimp Periclimenes imperator Bruce, 1967 (Pontoniinae)

    NARCIS (Netherlands)

    Fransen, C.H.J.M.; Goud, J.

    1999-01-01

    During the NNM/Maluku Expedition 1996, in the framework of the NNM Fauna Malesiana Marine Program, a shrimp belonging to the species Periclimenes imperator Bruce, 1967, was found on a nudibranch while diving at 20 m depth in Seri Bay, on the south coast of Ambon. Periclimens imperator has been recor

  4. 78 FR 2707 - Maryland Disaster # MD-00026

    Science.gov (United States)

    2013-01-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Maryland Disaster MD-00026 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  5. Design and fabrication of the retube transfer cask for Bruce N.G.S

    International Nuclear Information System (INIS)

    The retubing of CANDU reactors is a complex process which involves the removal and disposal of highly activated and contaminated calandria tubes and pressure tubes. For Bruce 'A' N.G.S., old pressure tubes will be removed from the reactor by cutting them into three segments; two end fitting assemblies which measure up to 3.2 m in length, and one pressure tube segment which measures up to 6.3 m. in length. Calandria tubes are 6.2 m in length. The function of the retube transfer cask is to provide for shielded transfer of these components between the reactor face and the in-ground disposal facility. This paper describes the design and fabrication of this cask. (author) 1 tab., 7 figs

  6. Validation of OHRFSP against actual operating data from Pickering NGS A and Bruce NGS A

    International Nuclear Information System (INIS)

    The Ontario Hydro Reactor Fuelling Simulation Program (OHRFSP) is a fuel management code that does a variety of core physics and related calculations useful in the design, safety analysis, and fuel performance analysis of CANDU-PHW reactors. The program has a modular structure that allows each of its individual modules to be run separately. Modules are linked by a common database, a common control package, and common data handling routines. Comparisons between OHRFSP models of Bruce NGS A and Pickering NGS A with operating data were used to validate the OHRFSP calculations. An improved methodology was developed for estimating the channel power peaking factor and average maximum channel, and bundle powers from a small sample of random instantaneous runs

  7. Rehabilitation and maintenance of hatch openings at Bruce B Generating Station

    International Nuclear Information System (INIS)

    The hatch program was launched with an objective to assess the strength of the hatch openings with respect to the changed loading conditions and label the hatches with the maximum allowable point load capacity. Once the analysis was complete, a labeling program was adopted to clearly inform equipment operators of the load limits. In some cases where existing hatches did not have sufficient strength to carry the floor design live load, the hatches were reinforced. With team effort and excellent support from the field staff, we were able to successfully accomplish this objective. All 387 hatches are now labeled at Bruce B. The labeling program also incorporated input from operations staff and the Joint Health and Safety Committee. Above all this program reinforced the need for 'Safety First' culture. (author)

  8. AECB staff annual assessment of the Bruce A Nuclear Generating Station for the year 1994

    International Nuclear Information System (INIS)

    AECB believe that Ontario Hydro operated Bruce A in a safe manner during 1994, and that the risk to workers and the public has been maintained at an acceptably low level. Radiation doses to workers and releases to the environment were well below regulatory limits. All special safety systems met availability targets. We noted improvements in operation and maintenance but some further improvements are still required. This is particularly true of the station's compliance with the Operating Licence. AECB believe that the station continues to be well managed, with a high priority placed on safety. However, there is a need for increased capability in the area of safety analysis and assessment. 4 tabs., 4 figs

  9. Monitoring the risk of loss of heat sink during plant shutdowns at Bruce Generating Station 'A'

    International Nuclear Information System (INIS)

    A relatively simple loss of shutdown heat sink fault tree model has been developed and used during unit outages at Bruce Nuclear Generation Station 'A' to assess, from a risk and reliability perspective, alternative heat sink strategies and to aid in decisions on allowable outage configurations. The model is adjusted to reflect the various unit configurations planned during a specific outage, and identifies events and event combinations leading to loss of fuel cooling. The calculated failure frequencies are compared to the limits consistent with corporate and international public safety goals. The importance measures generated by the interrogation of the fault tree model for each outage configuration are also used to reschedule configurations with high fuel damage frequency later into the outage and to control the configurations with relatively high probability of fuel damage to short intervals at the most appropriate time into the outage. (author)

  10. Neutron Overpower (NOP) system coverage during Bruce NGS A channel turn-around

    International Nuclear Information System (INIS)

    In the CANDU safety analysis process, a series of design basis accident are analyzed to confirm safety system effectiveness. Among all the postulated accidents, the Large Break Loss of Coolant (LBLOCA) sets the most demanding requirements on the speed and the reactivity depth of the shutdown reactivity devices. In such an accident, coolant discharge out of the fuel channels lead to a reactivity increase and power increase which is turned around by the shutdown systems action within seconds. In March 1993, the issue of fuel string relocation introducing additional positive reactivity for reactors fuelled against flow during a LBLOCA was identified. The combined reactivity effect could lead to power pulses much higher than would rise due to coolant voiding alone. To maintain adequate safety margins in the event of such postulated accident, the eight units of Bruce NGS A and B were derated to 60% full power

  11. On the transgressiveness of ambiguity: Richard Bruce Nugent and the flow of sexuality and race.

    Science.gov (United States)

    Bauer, J Edgar

    2015-01-01

    The study focuses on the slender corpus of literary work by Harlem Renaissance poet, author and visual artist Richard Bruce Nugent (1906-1987), arguably America's foremost Black aesthete. As an individualist in the footsteps of post-Hegelian and pre-Nietzschean philosopher Max Stirner (1806-1856), Nugent sought to re-think sexuality and race beyond fixed schemes of categorial distribution. To this end, Nugent deployed a strategy of sexual and racial ambiguity that aimed at situating the uniquely sexed and raced individual within the continuities of ever-diversifying Nature. Nugent's deconstructive approach of sexuality and race proves to be convergent with (but not genealogically dependent on) the universalization of sexual intermediariness and racial miscegenation postulated by German-Jewish sexologist Magnus Hirschfeld during the first third of the twentieth century. Nugent's non-identitarian conception of sex acts anticipated by more than a decade comparable insights propounded by Alfred Kinsey. PMID:25710478

  12. Water lancing of Bruce-A Unit 3 and 4 steam generators

    International Nuclear Information System (INIS)

    During the Bruce-A 1993 Unit 4 and 1994 Unit 3 outages, three water lancing operations were carried out along with chemical cleaning as part of the station boiler refurbishment program. The water lancing activities focused on three boiler areas.. 1) support plates to clean partially or completely blocked broach holes and prevent boiler water level oscillations, 2) hot leg U-bend supports (HLUBS) to remove deposits contributing to boiler tube stress corrosion cracking (SCC) and 3) tube sheets to dislodge sludge piles that potentially threaten boiler tube integrity and to flush out post chemical cleaning insoluble residues. The combination of water lancing and chemical cleaning effectively reduced broach hole blockage from up to 100% to 0-10% or less. As a result, boilers in Units 3 and 4 will operate for some time to come without concerns over water level oscillations. However, deposits remained in most tube support plate land areas. (author)

  13. Evaluation of a pilot fish handling system at Bruce NGS 'A'

    International Nuclear Information System (INIS)

    A pilot fish recovery system using a Hidrostal fish pump was tested in the Bruce NGS 'A' forebay during June, 1984. Despite low forebay fish concentrations, the system was capable of capturing 97,000 alewife/day (3900 kg) if operated continuously. Post-pumping survival averaged 97%. It is estimated that a single pump could handle alewife runs in the 40,000 to 70,000 kg range, but multiple pumps or a single larger pump would be required to assure station protection from the largest runs (>100,000 kg). Results indicate that tank/trailer return of pumped fish is feasible, but other alternatives for returning fish to Lake Huron are also being considered

  14. Bruce NGS A/B assessment of reactor vault fans on air mixing patterns

    International Nuclear Information System (INIS)

    The development and results of numerical simulations of air mixing patterns in the CANDU Bruce Nuclear Generating Station reactor vault, as a function of vault cooling fan combinations, are presented. The results of this analysis will serve as a basis for selecting appropriate fan combination scenarios to consider in the upcoming post-LOCA (loss of coolant) hydrogen-air-steam mixing analysis. Following a severe reactor accident in which fuel cooling is impaired, a significant amount of hydrogen may be produced from the steam/Zircaloy reaction and subsequently released into containment. The hydrogen ignition system mitigates the consequences of hydrogen burns to within acceptable safety limits. Igniters deliberately initiate a burn of the hydrogen-air-steam mixture as it reaches its flammability limits. However without adequate mixing, the igniters may become blinded by a region of non-flammable hydrogen mixture while an unfavourable hydrogen mixture forms elsewhere. The vault cooling fans play an important role in promoting mixing in the vault atmosphere. To help assess the effects of vault cooling fans on air mixing, an analysis was carried out to identify the air mixing patterns as a function of different fan availability combinations. The three-dimensional containment code, GOTHIC, was used to model the Bruce containment with modelling emphasis on the reactor vault geometry and the vault cooling system fans. Twenty-five fan combination air mixing simulations and eight tracer gas fan dispersion simulations were performed. The results showed that air mixing patterns created by individual fans can be superimposed to determine the effects of various fan combinations, there was symmetry of flow patterns between the west and east vault halves, and there was a general absence of significant stagnant regions in the reactor vault. 8 refs., 7 figs., 3 tabs

  15. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  16. Batch By Batch Longitudinal Emittance Blowup MD

    CERN Document Server

    Mastoridis, T; Butterworth, A; Jaussi, M; Molendijk, J

    2012-01-01

    The transverse bunch emittance increases significantly at 450 GeV from the time of injection till the ramp due to IBS. By selectively blowing up the longitudinal emittance of the incoming batch at each injection, it should be possible to reduce the transverse emittance growth rates due to IBS. An MD was conducted on April 22nd 2012 to test the feasibility and performance of the batch-by-batch longitudinal emittance blowup. There were three main goals during the MD. First, to test the developed hardware, firmware, and software for the batch-by-batch blowup. Then, to measure the transverse emittance growth rates of blown-up and "witness" batches to quantify any improvement, and finally to test the ALLInjectSequencer class, which deals with the complicated gymnastics of introducing or masking the new batch to various RF loops.

  17. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  18. Ashley W. Oughterson, MD: Surgeon, Soldier, Leader

    OpenAIRE

    Kunstman, John W.; Longo, Walter E

    2015-01-01

    Ashley W. Oughterson, MD, (1895-1956) was a longtime faculty surgeon at Yale University. He performed some of the earliest pancreatic resections in the United States. During World War II, Colonel Oughterson was the primary “Surgical Consultant” in the South Pacific and present at nearly every major battle. His meticulously kept diary is regarded as the foremost source detailing wartime surgical care. Colonel Oughterson led the initial Army team to survey Hiroshima and Nagasaki following the n...

  19. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD....

  20. Hydraulic Testing of Silurian and Ordovician Strata at the Bruce Site

    Science.gov (United States)

    Beauheim, R. L.; Avis, J. D.; Chace, D. A.; Roberts, R. M.; Toll, N. J.

    2009-05-01

    Ontario Power Generation is proposing a Deep Geologic Repository (DGR) for the long-term management of its Low and Intermediate Level Radioactive Waste (L&ILW) within a Paleozoic-age sedimentary sequence beneath the Bruce Site near Tiverton, Ontario, Canada. The concept envisions that the DGR would be excavated at a depth of approximately 680 m within the Ordovician Cobourg Formation, a massive, dense, argillaceous limestone. A key attribute of the Bruce site is the extremely low permeabilities associated with the thick Ordovician carbonate and argillaceous bedrock formations that will host and enclose the DGR. Such rock mass permeabilities are thought sufficiently low to contribute toward or govern a diffusion-dominated transport regime. To support this concept, hydraulic testing was performed in 2008 and 2009 in two deep boreholes at the proposed repository site, DGR-3 and DGR-4. The hydraulic testing was performed using a straddle-packer tool with a 30.74-m test interval. Sequential tests were performed over the entire open lengths of the boreholes from the F Unit of the Silurian Salina Formation into the Ordovician Gull River Formation, a distance of approximately 635 m. The tests consisted primarily of pressure-pulse tests, with a few slug tests performed in several of the higher permeability Silurian units. The tests are analyzed using the nSIGHTS code, which allows the entire pressure history a test interval has experienced since it was penetrated by the drill bit to be included in the test simulation. nSIGHTS also allows the model fit to the test data to be optimized over an n-dimensional parameter space to ensure that the final solution represents a true global minimum rather than simply a local minimum. The test results show that the Ordovician-age strata above the Coboconk Formation (70+ m below the Cobourg) have average horizontal hydraulic conductivities of 1E-13 m/s or less. Coboconk and Gull River hydraulic conductivities are as high as 1E-11 m

  1. Berglund, Bruce R. and Brian Porter-Szűcs, eds. 2013. Christianity and Modernity in Eastern Europe. Budapest and New York: Central European University Press. 386 pp.

    OpenAIRE

    Dorottya Nagy

    2015-01-01

    Berglund, Bruce R. and Brian Porter-Szűcs, eds. 2013. Christianity and Modernity in Eastern Europe. Budapest and New York: Central European University Press. 386 pp.  Reviewed by Dorottya Nagy, University of South Africa, Helsinki, Finland.

  2. Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

    OpenAIRE

    Hou, Ying-Chen Claire; Chittaranjan, Suganthi; Barbosa, Sharon González; McCall, Kimberly; Gorski, Sharon M.

    2008-01-01

    A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their requirement in the regulation of starvation-induced autophagy. We discovered that six cell death genes—death caspase-1 (Dcp-1), hid, Bruce, Buffy, debcl, and p53—as well as Ras–Raf–mitogen activated protein kinase signaling pathway components had a r...

  3. Retrofitting alarm prioritization at Bruce A: strategy development and implementation experience

    International Nuclear Information System (INIS)

    A prioritization strategy for computer-displayed control room alarms has been developed for Bruce A to better assist operations staff in visually identifying key alarms and judging the relative importance of alarms. The strategy consists of assigning each alarm indicative of a problem to be addressed to one of five priority categories. Each alarm is assigned to an alarm category based on an off-line analysis of the consequence and response characteristics applicable to the alarm for three plant operating contexts. The colour of the alarm message is used to convey the priority category of each alarm in computer-based alarm displays. In addition, alarms indicative of non-problematic changes in the state of plant equipment and processes are given a separate colour assignment to visually differentiate them from alarms indicative of problems. This paper outlines the user-based approach employed in the prioritization strategy development, describes the key features of the prioritization strategy adopted, and discusses the initial experience in systematically determining the priority assignments for all 6000 computer-based alarms associated with each generating unit. (author)

  4. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  5. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  6. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  7. 75 FR 69862 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2010-11-16

    ... exist or develop on other helicopters of the same type design. Therefore, this AD requires, within 4...-AD. Applicability: Model MD900 helicopters, with lower main rotor hub (hub), part number 900R2101008... the main rotor hub (hub) for a crack. If a crack is found, this AD requires, before further...

  8. 76 FR 41662 - Airworthiness Directives; MD Helicopters, Inc. Model MD900 Helicopters

    Science.gov (United States)

    2011-07-15

    ... helicopters of this same type design. AD Requirements This AD requires a visual inspection, and if necessary...) Inspect the main rotor lower hub assembly for a crack by following the specified portions of MD Helicopter... rotor lower hub assembly (lower hub) for a crack, and if you find a crack, before further...

  9. 76 FR 1993 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

    Science.gov (United States)

    2011-01-12

    ... (75 FR 34661). That NPRM proposed to require installing fuel level float and pressure switch in-line... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Maintenance Manual (AMM) defueling procedure MD80 AMM 12-13-00. The correct reference is Boeing MD80 AMM...

  10. Optimizing the use of operating experience at Ontario Hydro's Bruce Nuclear Generating Station 'A'

    International Nuclear Information System (INIS)

    One of the most significant lessons learned from the Three Mile Island event (March 1979), and again with the Chernobyl disaster - (April 1986) was the ongoing requirement to learn from our mistakes and near misses, and those of our fellow utilities around the world: so that as an industry we do not repeat the same mistakes. The very future of our industry will depend on how well each one of us accomplishes this important ask. This paper describes in detail the challenges encountered by one station when incorporating a comprehensive 'Operating Program'. It begins with the Corporate Office's directives to its stations for such a program; and follows up with the details of the actual station implementation of the program, and day to day operating experiences. The paper describes in detail the following Operating Experience programs: - Root Cause Determination process. The Institute of Nuclear Power Operations, Human Performance Enhancement System (HPES) as an integral component of the Root Cause process. Finding solutions for our station for problems identified elsewhere is covered herein; - Significant Event Recommendation Tracking System: - Commitment Tracking System; - Operating Experience (Sharing Lessons Learned) System. The paper will show all the above processes tie closely together and complement each other. The paper discusses the staff required for such processes and their training requirements. It recommends process time lines, reporting mechanisms, and sign off requirements. It will describe the equipment utilized to carry out this work effectively, and with a minimum of staff. One unique feature of the Bruce 'A' system is an 'Effectiveness Follow-Up', usually three to six months after the event recommendations have been completed. By rechecking the finished actions and reviewing them with the personnel involved with the originating event we ensure that the real root causes have been identified and resolved. (author)

  11. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from

  12. Feasibility analysis of the utilization of moderator heat for agricultural and aquacultural purposes, Bruce nuclear power development

    International Nuclear Information System (INIS)

    A study is presented of the feasibility of using moderator reject heat from the Bruce nuclear power development either to heat greenhouses or to aid in a warm water hatchery or aquaculture operation. The study examines heat extraction and delivery plans, reliability of supply, pricing schedules, the Ontario greenhouse industry, site selection criteria, water transmission and distribution, costs, approvals required, and a construction timetable. Total system analysis shows that a greenhouse facility would be viable but the aquaculture/hatchery scheme is more cost-effective. (E.C.B.)

  13. Design and verification of computer-based reactor control system modification at Bruce-A candu nuclear generating station

    International Nuclear Information System (INIS)

    The Reactor Control System at Bruce-A Nuclear Generating Station is going through some design modifications, which involve a rigorous design process including independent verification and validation. The design modification includes changes to the control logic, alarms and annunciation, hardware and software. The design (and verification) process includes design plan, design requirements, hardware and software specifications, hardware and software design, testing, technical review, safety evaluation, reliability analysis, failure mode and effect analysis, environmental qualification, seismic qualification, software quality assurance, system validation, documentation update, configuration management, and final acceptance. (7 figs.)

  14. Examination of oxides and deposits on tubes removed from Bruce units

    International Nuclear Information System (INIS)

    At the Bruce Nuclear Power Generating Station (BNPGS), sensitized Alloy 600 steam generator (SG) tubing in different units has exhibited different secondary side corrosion behavior at and/or near the upper roll joint transition zone (RTZ) of the tubes. Wastage and pitting was observed on tubes from Unit 3, while Unit 4 SG tubing has exhibited circumferential stress corrosion cracking (SCC) and intergranular attack (IGA) in addition to wastage and pitting. Intergranular attack in one SG from Unit 5 has been documented, whereas only micropitting has been observed on tubes from Units 6, 7 and 8. In preheaters (PH), which are also tubed with sensitized alloy 600, only a small number of shallow flaws with a crystallographic appearance were observed on some of the tubes. Of these corrosion mechanisms, the SCC currently affecting Unit 4 is of the most concern as it challenges the operating life of all of the SGs in that unit. To investigate the causes of the different corrosion behavior observed in different units, detailed surface and microscopy analysis was performed on the SG tubing (within the sludge pile and in the free span regions) and PH tubing (in the free span region) removed from different units. The results indicated that the oxides formed on all tube specimens were enriched in chromium at the outer surface with its absolute concentration being close to that in the base metal, suggesting that the pH of the crevice environment is from mildly acidic to mildly basic. It was also observed that the oxide morphology and thickness for SG tubes that suffered degradation was different compared to those tubes that appeared unaffected. Oxide thickness also appeared to be significantly greater on the PH tubing compared to the SG tubing. Finally, the degraded SG tubing also exhibited a greater level of contamination from the secondary side environment, with elements such as aluminum, silicon and copper being detected. Results from Raman spectroscopic analyses further

  15. 78 FR 35773 - Airworthiness Directives; MD Helicopters, Inc. (MDHI), Helicopters

    Science.gov (United States)

    2013-06-14

    ... the MDHI Model MD900 helicopters with certain main rotor blade (MRB) retention bolts (bolts) installed... MD 900 helicopters with a main rotor blade retention bolt (bolt), part number (P/N) 900R3100001-103... exist or develop on other products of the same type design. Related Service Information We have...

  16. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  17. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter...

  18. Single-block collision attack on MD5

    NARCIS (Netherlands)

    Stevens, M.M.J.

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security

  19. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...) entitled ``Safety Zone; Patuxent River, Patuxent River, MD'' in the Federal Register (76 FR 36447). We... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... safety zone during the ``NAS Patuxent River Air Expo '11,'' which consists of aerial...

  20. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    Stevens, M.M.J.; Lenstra, A.K.; Weger, B. de

    2012-01-01

    We present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen message prefixes $P$ and $P'$

  1. DFT-MD simulations of shocked Xenon

    Science.gov (United States)

    Magyar, Rudolph J.; Mattsson, Thomas R.

    2009-03-01

    Xenon is not only a technologically important element used in laser technologies, jet propulsion and dental anesthesia, but it is also arguably the simplest material in which to study the metal-insulator transition at high pressure. Because of its closed shell electronic configuration, Xenon is often assumed to be chemically inert, interacting almost entirely through the van der Waals interaction, and at liquid density, is typically modeled well using Leonard-Jones potentials. However, such modeling has a limited range of validity as Xenon is known to form compounds at normal conditions and likely exhibits considerably more chemistry at higher densities when hybridization of occupied orbitals becomes significant. In this talk, we present DFT-MD simulations of shocked liquid Xenon with the goal of developing an improved equation of state. The relative importance of the van der Waals interaction compared to other Coulomb interactions is considered, and estimates of the relative accuracy of various density functionals are quantified. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  2. Performance evaluation of the air exhaust sampling and monitoring systems at the Bruce-A nuclear generating station

    International Nuclear Information System (INIS)

    The Bruce-A plant consists of four 825 MWe CANDU nuclear generating units. Each unit has 2 ventilation exhausts; a nominally Contaminated exhaust and a nominally Non-Contaminated exhaust. Each exhaust stream is monitored continuously for radioiodine, for radioactive particulate and for noble gases. The monitors provide warning of increasing emissions (i.e., a control function) and also provide a measure of station emission performance. The monitor systems consist of a probe in the exhaust stream, a sample line about 20 m long, and the monitor itself. Standards for probe design are available and some guidelines for sample-line design can be extracted from published data. Little, if any, in-station performance data are available for sampling systems, although plateout of radioiodine and deposition of particulate have been the subject of much speculation and a little laboratory study. A major in-station study has been undertaken at Bruce-A to obtain relevant in-station data. By comparisons of the concentrations of iodine, methyl iodine, and uranine particulate found at various points in the system, it could be concluded that no loss of iodine, methyl iodine, or particulate occurred in the ∼ 20 m line and that particulate material is sampled accurately even by a poorly designed probe mounted in a very poor location

  3. Experience in ultrasonic gap measurement between calandria tubes and liquid injection shutdown systems nozzles in Bruce Nuclear Generating Station

    International Nuclear Information System (INIS)

    The gaps between calandria tubes (CT) and Liquid Injection Shutdown System (LISS) nozzles at the Bruce Nuclear Generating Station ''A'' (Bruce A) are known to decrease with time due to radiation induced creep/sag of the calandria tubes. If this gap decreases to a point where the calandria tubes come into contact with the LISS nozzle, the calandria tubes could fail as a result of fretting damage. Proximity measurements were needed to verify the analytical models and ensure that CT/LISS nozzle contact does not occur earlier than predicted. The technique used was originally developed at Ontario Hydro Technologies (formerly Ontario Hydro Research Division) in the late seventies and put into practical use by Research and Productivity Council (RPC) of New Brunswick, who carried out similar measurements at Point Lepreau NGS in 1989 and 1991. The gap measurement was accomplished y inserting an inspection probe, containing four ultrasonic transducers (2 to measure gaps and 2 to check for probe tilt) and a Fredericks electrolytic potentiometer as a probe rotational sensor, inside LISS Nozzle number-sign 7. The ultrasonic measurements were fed to a system computer that was programmed to convert the readings into fully compensated gaps, taking into account moderator heavy water temperature and probe tilt. Since the measured gaps were found to be generally larger than predicted, the time to CT/LISS nozzle contact is now being re-evaluated and the planned LISS nozzle replacement will likely be deferred, resulting in considerable savings

  4. Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.

    Science.gov (United States)

    Hou, Ying-Chen Claire; Chittaranjan, Suganthi; Barbosa, Sharon González; McCall, Kimberly; Gorski, Sharon M

    2008-09-22

    A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death-related genes to determine their requirement in the regulation of starvation-induced autophagy. We discovered that six cell death genes--death caspase-1 (Dcp-1), hid, Bruce, Buffy, debcl, and p53-as well as Ras-Raf-mitogen activated protein kinase signaling pathway components had a role in autophagy regulation in D. melanogaster cultured cells. During D. melanogaster oogenesis, we found that autophagy is induced at two nutrient status checkpoints: germarium and mid-oogenesis. At these two stages, the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death. Mutations in Atg1 and Atg7 resulted in reduced DNA fragmentation in degenerating midstage egg chambers but did not appear to affect nuclear condensation, which indicates that autophagy contributes in part to cell death in the ovary. Our study provides new insights into the molecular mechanisms that coordinately regulate autophagic and apoptotic events in vivo. PMID:18794330

  5. The Achromatic Telescopic Squeezing (ATS) MD part III

    CERN Document Server

    Fartoukh, S; Goddard, B; Hofle, W; Jacquet, D; Kruk, G; Lamont, M; de Maria, R; Miyamoto, R; Mueller, G; Pojer, M; Ponce, L; Redaelli, S; Ryckx, N; Steinhagen, R; Strzelczyk, M; Vanbavinckhove, G; Wenninger, J

    2011-01-01

    This note highlights the results obtained during the third so-called ATS MD which took place in 2011. The goal of this MD was extremely challenging, targeting a pre-squeezed beta* of 40 cm in ATLAS and CMS, followed by a telescopic squeeze of these two insertions to finally reach a beta* of 10 cm both at IP1 and IP5. Due to the rather poor machine availability during the MD period, the time initially allocated to the ATS studies was hardly cut by a factor of 2, and "only" the achromatic pre-squeeze down to beta*=40 cm was demonstrated with beam.

  6. Single-block collision attack on MD5

    OpenAIRE

    Stevens, Marc

    2012-01-01

    In 2010, Tao Xie and Dengguo Feng \\cite{cryptoeprint:2010:643} constructed the first single-block collision for MD5 consisting of two 64-byte messages that have the same MD5 hash. Details of their attack, developed using what they call an evolutionary approach, has not been disclosed ``for security reasons''. Instead they have posted a challenge to the cryptology community to find a new different single-block collision attack for MD5. This paper answers that challenge by presenting a single-b...

  7. MD 239 on Collide and Squeeze (part 2)

    CERN Document Server

    Gorzawski, Arkadiusz; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    Colliding the beams during the squeeze to profit from Landau damping due to head--on beam-beam and beta--star leveling are two operational modes that may have to be used in a not so distant future at the LHC. This MD aimed at improving the orbit control during the squeeze with much improved handling of orbit feedback references and at evaluating instruments and techniques to maintain the beam in collisions with active feedback on luminosity or beam position. This MD also integrated for the first time synchronized collimator measurements. Comparison of the settings with the previous MD allowed a validation of the long term stability of collide and squeeze.

  8. Charge separation reaction in clusters of polar molecules. MD simulations

    International Nuclear Information System (INIS)

    Rate constant of intermolecular electron transfer (ET) in a photoexcited donor-acceptor model system solvated by a cluster of polar molecules has been expressed in terms of the statistical distribution of the electrostatic potential energy difference between the reacting sites. This distribution has been calculated for a particular case of acetonitrile clusters at ∼ 120 K by MD computer simulation. The MD values of the cluster reorganization energy and the ET rate constant have been compared with the corresponding MD results for the donor-acceptor pair solvated in bulk acetonitrile and with theoretical predictions based on the continuum model. (author)

  9. MD5Hash加密算法在SQL Server2005中的应用%Application of MD5 Hash Encryption Algorithm in SQL Server 2005

    Institute of Scientific and Technical Information of China (English)

    李红日

    2011-01-01

    在对MD5算法进行简要描述的同时,对MD5算法的原理作深入分析.介绍在C创建MD5 Hash算法的函数,在SQL Server中应用MD5哈希算法,并且经过测试可以准确实现MD5 Hash加密算法.

  10. Cryptanalysis of the Hash Function MD5%关于Hash函数MD5的解析

    Institute of Scientific and Technical Information of China (English)

    毛明; 陈少晖; 袁征; 贾永兴

    2009-01-01

    This paper is about the cryptanalysis of the Hash function MDS, on the basis of the paper concerning the breaking the MD5 which was written by Wang et al.In this paper,the eighth step of MD5 algorithm was taken for exam-ple and the properties of the F function and the effective control of the differential path were introduced.The MD5 algo-rithm was cryptanalyzed from both the manual calculation and the testing program and some part of the paper written by Wang was amended.Finally, the conditions and key points of meeting the differential characteristics were discussed.In general, this paper plays an important role in eryptanalyzing and breaking the MD5 algorithm.%在王小云写的关于分析MD5算法文章的基础上,对MD5算法的破译进行进一步的解析.以MD5算法第八步为例,介绍了F函数的性质和差分路径的有效控制.从手工推算和程序实现两方面时MD5算法进行了解析和测试,对王的文章进行了部分修正,进一步说明了满足差分特征的条件和关键点.这对MD5和其他Hash函数的分析破译有着重要的作用.

  11. The failure of the pressure tube in fuel channel NO6 of Bruce NGS-A unit 2 in March 1986

    International Nuclear Information System (INIS)

    The events leading up to the failure of Bruce NGS-A Unit 2 pressure tube NO6 are described. Based on the subsequent examination of the tube, reactor operating history and pressure tube manufacturing information, the failure sequence is deduced. Remedial actions which have been adopted for avoiding similar occurrences are listed

  12. Berglund, Bruce R. and Brian Porter-Szűcs, eds. 2013. Christianity and Modernity in Eastern Europe. Budapest and New York: Central European University Press. 386 pp.

    Directory of Open Access Journals (Sweden)

    Dorottya Nagy

    2015-01-01

    Full Text Available Berglund, Bruce R. and Brian Porter-Szűcs, eds. 2013. Christianity and Modernity in Eastern Europe. Budapest and New York: Central European University Press. 386 pp.  Reviewed by Dorottya Nagy, University of South Africa, Helsinki, Finland.

  13. Bruce's Magnificent Quartet: Inquiry, Community, Technology and Literacy--Implications for Renewing Qualitative Research in the Twenty-First Century

    Science.gov (United States)

    Davidson, Judith

    2014-01-01

    Bruce and Bishop's community informatics work brings forward four critical concepts: inquiry, community, technology, and literacy. These four terms serve as the basis for a discussion of qualitative research in the twenty-first century--what is lacking and what is needed. The author suggests that to resolve the tensions or challenges…

  14. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1....... The principles are also applicable for other queueing systems...

  15. Autentikasi Pesan Menggunakan Algoritma Message Digest 5 (MD5)

    OpenAIRE

    Simamora, Ali Makmur

    2015-01-01

    When receive or send a message on the network internet, there are some issue which very important namely problem wholeness and authentication. This script discusses about authentication of message with Message Digest algorithm 5. The writter designed an application to ensure the integrity of the message by algorithm MD5. MD5 is a tool to declare the validity of (authentic) sent messages as well as message. To express validity of message in the text or file will used encryption method, so the ...

  16. Flow-induced vibration and acoustic behaviour of CANFLEX-LVRF bundles in a Bruce B NGS fuel channel

    International Nuclear Information System (INIS)

    Frequency/temperature sweep tests were performed in a high-temperature/high-pressure test channel to determine the acoustic and flow-induced vibration characteristics of the CANFLEX-LVRF bundle. The vibratory response of CANFLEX-LVRF bundles was compared with that of 37-element fuel bundles under Bruce B NGS fuel channel normal operating conditions. The tests were performed with a 12-bundle string of CANFLEX-LVRF bundles as well as a mixed string for the transition core. The tests showed that the LVRF bundles performed as required without failure or gross geometry changes. The mixed fuel strings behaved in a manner similar to that of a string of CANFLEX-LVRF bundles. (author)

  17. Research of the Hash Algorithm Based on MD5%MD5散列算法的研究

    Institute of Scientific and Technical Information of China (English)

    姜学军; 曹烨

    2014-01-01

    借鉴了M.M.J.Stevens的碰撞思路,重新编写了MD5碰撞算法中的核心循环,主要提供一对MD5碰撞产生的过程以及碰撞的完成.通过实验统计分析,利用改进的MD5碰撞算法找到一对碰撞信息所用平均时间不多于60s,且该算法较之传统的MD5碰撞算法具有更好的可读性和可移植性.

  18. Great 21st century physician ‘One Health’ leader dies. Ronald M. Davis, MD

    Directory of Open Access Journals (Sweden)

    Bruce Kaplan

    2009-03-01

    Full Text Available It is with tremendous sadness that we report the passing, on 6 November 2008, of Ronald M. Davis, MD, past President of the American Medical Association (AMA and a major supporter of the One Health Initiative. Indeed, the AMA wouldn't have passed its historic One Health Resolution without Ron's leadership. As the first preventive medicine physician to be president of the AMA, he recognised the need for collaboration between veterinarians and physicians. As he said, ‘I was primed for the issue of One Health’.Roger Mahr, who was President of the AVMA at the same time, contacted Ron to discuss bringing animal and human medicine together. They met and had dinner together. After Roger educated Ron about the issues, Ron told him that he would be happy to help. Ron not only advocated One Health principles within AMA, but he personally represented AMA on the AVMA One Health Initiative Task Force and contributed materially to the development of the Task Force recommendations (www.avma.org/onehealth/.This was a case where the right people were in the right place at the right time. In our subsequent One Health collaborations regarding drafting the AMA One Health Resolution and other related issues, Ron always graciously and expeditiously supported and guided our efforts with much wisdom.Tragically, not long after the AMA passed the One Health Resolution in June 2007, Ron was diagnosed with stage 4 pancreatic cancer.He fought the disease with grace and dignity. The New York Times reported on his battle. (www.nytimes.com/2008/09/23/health/23voic.html?partner=rssnyt&emc=rss.On 14 June 2008, at the AMA Annual Meeting of the House of Delegates, Ron gave a very moving speech entitled Legacies in the circle of life. The transcript can be read at www.ama-assn.org/ama/no-index/news-events/18670.shtml and the video can be watched at www.webguild.com/TeamRon/.The world has lost a great man and we have lost an esteemed colleague, friend, and One Health champion

  19. Cummins MD & HD Accessory Hybridization CRADA -Annual Report FY15

    Energy Technology Data Exchange (ETDEWEB)

    Deter, Dean D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-10-01

    There are many areas of MD and HD vehicles that can be improved by new technologies and optimized control strategies. Component optimization and idle reduction need to be addressed, this is best done by a two part approach that includes selecting the best component technology, and/or architecture, and optimized controls that are vehicle focused. While this is a common focus in the light duty industry it has been gaining momentum in the MD and HD market as the market gets more competitive and the regulations become more stringent. When looking into systems optimization and idle reduction technologies, affected vehicle systems must first be considered, and if possible included in the new architecture to get the most benefit out of these new capabilities. Typically, when looking into idle reduction or component optimization for MD/HD, the vehicle s accessories become a prime candidate for electrification or hybridization. While this has already been studied on light duty vehicles (especially on hybrids and electric vehicles) it has not made any head way or market penetration in most MD and HD applications. If hybrids and electric MD and HD vehicles begin to break into the market this would be a necessary step into the ability to make those vehicles successful by allowing for independent, optimized operation separate from the engine.

  20. 基于C#的MD5加密算法的应用%Application of the MD5 algorithm based on C#

    Institute of Scientific and Technical Information of China (English)

    林宗朝

    2011-01-01

    介绍了WEB SYSTEM中的密钥安全性能。主要讨论了WEB SYSTEM中MD5加密算法,包含客户password安全性分析、MD5加密算法概述、基于C#的MD5加密应用介绍,以及IT SYSTEM中MD5算法的应用与IMPROVEMENT等问题。%The key safety properties of the WEB system is described,and the.MD5 encryption algorithm is discussed mainly including the user password security analysis,MD5 encryption algorithm summary,MD5 encryption applications based on the C# and the improvement of MD5 algorithm.

  1. BI MD Studies on June 29th 2011

    CERN Document Server

    Belohrad, D; Bravin, E; Calvo, E; Dehning, B; Emery, J; Favier, M; Gras, JJ; Guerrero, A; Jeff, A; Lefevre, T; Rabiller, A; Roncarolo, F; Sapinski, M; Soby, L; Steinhagen, R

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 29-June-2011 (from 10 p.m. to 07 a.m.), dedicated to study Beam Current Monitors (BCT), Wire Scaners (WS), Synchrotron Radiation (BSRT), Beam Position (BPM), Wall Current (WCM) and Beam Gas Ionization (BGI) monitors. The MD aimed at performing different studies on the individual monitors. At the same time, it was possible to perform calibration studies with the Abort Gap (AGM) and Longitudinal Density (LDM) monitors that share the extracted light with the BSRT. Additionally some observations about the beam stability and emittance dependence on the chromaticity were performed.

  2. Proposed deep geologic repository for low and intermediate-level radioactive waste at the Bruce site, Tiverton, Ontario

    International Nuclear Information System (INIS)

    A Deep Geologic Repository (DGR) for the long-term management of operational Low and Intermediate Level Radioactive Waste (LLW and ILW) is being proposed by Ontario Power Generation at the 900-ha Bruce Nuclear site. The Bruce Nuclear site is located approximately 225 kilometres northwest of Toronto near Tiverton, Ontario. The project is currently undergoing environmental assessment. This paper describes the current concept for Ontario Power Generation's proposed DGR. The underground repository concept is comprised of horizontally-excavated emplacement rooms arranged in panels with access provided via two vertical concrete-lined shafts. The emplacement rooms would be constructed at a depth of about 680 m within limestone. This limestone formation is laterally extensive and is directly overlain by 200 m of low permeability shale. The low-permeability diffusion-controlled geosphere immediately surrounding the repository will assure long-term isolation of the LLW and ILW. LL W and ILW will be retrieved from nearby above-ground storage structures and then transferred to the DGR. LLW and ILW will also be shipped directly from the nuclear generating stations to the DGR. In this concept, most waste packages are retrieved and transferred 'as is' with shielding added, as necessary, to protect workers. The waste packages are lowered by hoist to the repository horizon and then transferred by forklift or, in the case of large and heavy packages, by rail car to emplacement rooms. Waste packages are stacked within emplacement rooms by forklift or gantry crane and, when full, the rooms are isolated by closure walls. It is expected that the repository will be open for at least 50 years to receive LLW and ILW from the operation of Ontario's nuclear reactors. When filled with waste and after receipt of all necessary regulatory approvals, the repository will be sealed by placing low permeability concrete and clay-based plugs in each shaft. A preliminary safety assessment indicates

  3. Analysis of the message digest algorithm MD5%报文摘要算法MD5分析

    Institute of Scientific and Technical Information of China (English)

    燕辉; 叶震; 董泽浩; 高柯俊

    2002-01-01

    随着计算机网络的发展,社会对网络安全的要求也越来越紧迫。文章回顾了网络安全的目标、几种网络攻击方法和网络安全技术,重点分析了普遍用在数据签名中的MD5报文摘要算法。首先描述了MD5报文摘要算法,并对其进行了详细分析,找出了它的缺陷,最后推荐了一种为克服此缺陷而对MD5算法进行的改进方法。

  4. Hardware Implementation of HMAC-MD5 Algorithm%HMAC-MD5算法的硬件实现

    Institute of Scientific and Technical Information of China (English)

    吴旭凡; 胡晨; 田渊; 丁黄胜

    2003-01-01

    信息安全体系中的消息验证是一个非常重要的方面.采用以散列函数为基础的消息验证编码是其中的一种重要方法.现提出了硬件实现一种以MD5算法为基础的消息验证编码(HMAC-MD5)的电路结构.该电路结构通过对MD5核心运算模块的复用,缩小了电路规模,达到了较高的处理速度.用VerilogHDL描述电路结构,并且在FPGA上验证了该结构的正确性.

  5. Installation of an irradiated fuel bundle discharge counter at Bruce NGS-B 3 000 MW(e) CANDU power station

    International Nuclear Information System (INIS)

    Design, manufacture and installation of an irradiated fuel bundle discharge counter for the multi-unit CANDU Bruce NGS-B Generating Station involved contributions from the International Atomic Energy Agency (Agency), designers (AECL), contractors, manufacturers, utility and the regulatory agency. The installation at Bruce NGS-B was the first made by the Agency as a retrofit to a multi-unit CANDU reactor approaching its fist critical operation, where the whole project was the responsibility of the Agency and where the original design of the reactor had not had provision for the Agency equipment. The scheduling and integration of the installation into the normal activities involved in starting up a 3 000 MW(e) multi-unit generating station were successfully achieved. The Agency has demonstrated the capability and performance of the fuel discharge counter

  6. Research and Improvement of MD5 Algorithm%MD5算法的研究与改进

    Institute of Scientific and Technical Information of China (English)

    毛熠; 陈娜

    2012-01-01

    MD5 algorithm has important applications in the field of data encryption such as digital signature, identity authentication and so on, but it can not resist differential attack and dictionary attack. This paper does certain special transform on some related variables during message preprocessing course of MD5 to improve probability of data high overflow, and increase the avalanche effect and difficulty of differential cryptanalysis, so that collision problem of MD5 algorithm is solved. Through doing collision detection, coincidence detection of encrypted values before and after improvement for improved algorithm, the improved MD5 is proved safe and practical.%MD5算法在数字签名、身份认证等数据加密领域有重要的应用,但其无法抵御差分攻击和查字典攻击.为此,通过对算法消息处理过程中涉及的一些变量进行特殊变换,提高运算中数据高位溢出的几率,增强其雪崩效应,增加差分分析的难度,由此解决MD5算法的碰撞问题.对改进的算法进行碰撞检测、加密值重合检测以及改进前后加密值的重合检测,结果证明其具有较高的安全性和实用价值.

  7. "Help, everybody's struggeling with what this is?" : En innehållsanalys av Diane Sawyers framställning av Bruce Jenner

    OpenAIRE

    Tolinsson, Sara; Eriksson, Hanna

    2016-01-01

    The American society is dominated by a heterosexual powerstructure with norm-filled social values. It is difficult for norm-breaking humans who live outside of the gender stereotypical social model, this includes the group of transgenders. The renowned olympic decathlon athlete Bruce Jenner, also known from the TV-series Keeping Up with the Kardashians, came out as a transgender woman in April, 2015, which aroused a great news reporting. This is a qualitative content analysis with the aim to ...

  8. Book review of ‘Extraordinary anthropology : transformations in the field’ by Jean-Guy A. Goulet and Bruce Granville Miller, Lincoln, NE : University of Nebraska Press, 2007.

    OpenAIRE

    Mughal, Muhammad Aurang Zeb

    2010-01-01

    Just as diverse as cultures in the world with which anthropologists spend time being ‘‘participants’’, so varied are the experiences of these anthropologists, depending upon the circumstances in which they work. In sixteen essays of Extraordinary Anthropology: Transformations in the Field Jean-Guy A. Goulet of Saint Paul University in Ottawa and Bruce Granville Miller of the University of British Columbia have compiled experiential accounts of many anthropologists while encountering diverse c...

  9. Research of MD5 shadow table method based on MD5 algorithm%一种融入MD5的影子表算法研究

    Institute of Scientific and Technical Information of China (English)

    袁满; 康峰峰; 黄刚

    2013-01-01

    As for the rapid extraction of source data, the rapid identification of changing data and the rapid incremental extraction of data, underlying the analysis of the working principle of the traditional shadow table, this paper proposed a kind of improved linear algorithm which merged MD5 algorithm into the ST. It scanned compared tables for the linear and eliminates unnecessary inverse operation. During scanning these tables, it employed MD5 algorithm to calculate the whole record ' fingerprint ' , it reduced the frequency and duration of string matching, and it could quickly recognize the changed records. The algorithm was verified practically, and the result shows that the proposed algorithm can improve the efficiency of data extraction in database. Incremental extraction method based on shadow table is a general incremental capturing method, and it can be implemented in any database. These applications can easily be transplanted in all kinds of platforms, so it is suitable to solve the heterogeneous database replication issues.%为了快速提取源头数据、快速识别变化记录以及实现数据的快速增量提取,在剖析传统影子表法的工作原理上,提出基于MD5算法的影子表法的改进型线性算法,对对比表进行线性扫描,排除了不必要的回扫操作;同时通过MD5算法计算整条记录的“指纹”,降低了字符串比对次数和时间,能够迅速识别出发生变化的记录.对所提出算法进行了应用测试,结果表明通过融入MD5算法后的影子表法提高了数据提取效率.基于影子表的增量提取方法是一种通用的增量捕获方法,能在任何数据库上实现;应用程序可以方便地在多种平台间移植,因此很适合解决异构数据库复制问题.

  10. Inactivation of the Oxytocin and the Vasopressin (Avp) 1b Receptor Genes, But Not the Avp 1a Receptor Gene, Differentially Impairs the Bruce Effect in Laboratory Mice (Mus musculus)

    OpenAIRE

    Wersinger, Scott R.; Temple, Jennifer L.; Heather K Caldwell; Young, W. Scott

    2007-01-01

    The Bruce effect is a pheromonally mediated process whereby exposure to chemosensory cues from an unfamiliar male terminates pregnancy in a recently mated female. Pharmacological and genetic evidence implicates both oxytocin (Oxt) and vasopressin (Avp) in the regulation of social memory in males, but less work has been done in females. We tested the extent to which the Avp receptors (Avprs) 1a and 1b and Oxt are essential for the Bruce effect, a phenomenon that relies on olfactory memory. Adu...

  11. Preliminary post-closure safety assessment of repository concepts for low level radioactive waste at the Bruce Site, Ontario

    International Nuclear Information System (INIS)

    The preliminary post-closure safety assessment of permanent repository concepts for low-level radioactive waste (LLW) at the Ontario Power Generation (OPG) Bruce Site is described. The study considered the disposal of both short and long-lived LLW. Four geotechnically feasible repository concepts were considered (two near-surface and two deep repositories). An approach consistent with best international practice was used to provide a reasoned and comprehensive analysis of post-closure impacts of the repository concepts. The results demonstrated that the deep repository concepts in shale and in limestone, and the surface repository concept on sand should meet radiological protection criteria. For the surface repository concept on glacial till, it appears that increased engineering such as grouting of waste and voids should be considered to meet the relevant dose constraint. Should the project to develop a permanent repository for LLW proceed, it is expected that this preliminary safety assessment would need to be updated to take account of future site-specific investigations and design updates. (author)

  12. Hysterothylacium gibsoni sp. nov. and H. tetrapteri (Bruce et Cannon, 1989) (Nematoda: Ascaridida) from the Chinese marine fishes.

    Science.gov (United States)

    Xu, Zhen; Li, Liang; Zhang, Lu-Ping

    2014-06-01

    A new species of ascaridoid nematode, Hysterothylacium gibsoni sp. nov., is described based on specimens collected from the intestine of the slender lizardfish Saurida elongata (Temminck et Schlegel) (Aulopiformes: Synodontidae) in the Yellow Sea, China. The new species differs from its congeners by its small body size (12.8-13.2 mm), the absence of cervical alae, a very short intestinal caecum (representing 8.86-9.52% of oesophageal length) and a long ventricular appendix (intestinal caecum to ventricular appendix ratio 1:15.3-20.0), short spicules (0.38-0.41 mm, representing 2.97-3.11% of body length), the number and arrangement of the caudal papillae (25-28 pairs arranged as follows: 18-22 pairs precloacal, 3 pairs paracloacal, and 3-4 pairs postcloacal). In addition, Hysterothylacium tetrapteri (Bruce et Cannon, 1989) is also redescribed based on the material collected from the striped marlin Kajikia audax (Philippi) (Perciformes: Istiophoridae) in the South China Sea. PMID:24827106

  13. Behaviour of Bruce NGS A fuel irradiated to a burnup of ∼ 500 MWh/kgU

    International Nuclear Information System (INIS)

    Fuel elements from three fuel bundles discharged from Bruce NGS A at burnups of 478 to 518 MWh/kgU were examined in the hot cell facilities at Chalk River Laboratories. The examination results show that the fuel operated at higher than expected temperatures, resulting in fission gas releases of up to (and probably exceeding) 24%. Sheathing strains of up to 3% were also observed, indicating a high level of pellet-clad interaction (PCI). This unexpected behaviour is believed to be related to a burnup-dependent reduction in UO2 thermal conductivity. All of the outer elements examined from two of the bundles apparently experienced stress corrosion cracking-related failures in the end cap weld region and sheath as a result of PCI. No failures were observed in the elements examined from the third bundle. The factors believed to have primarily influenced performance are end cap weld geometry and UO2 density. Pellet geometry, stack length and sheath properties may also have influenced performance. The results of these examinations may help to facilitate performance enhancements to existing and future fuel bundle designs. Until such an optimization takes place, the current bundle average burnup limit in Ontario Hydro reactors of 450 MWh/kgU is justified. (Author) (13 refs., 10 figs., tab.)

  14. Determination of 14C in spent moderator ion-exchange resin from Bruce Nuclear Generating Station A

    International Nuclear Information System (INIS)

    Spent ion-exchange resins are produced in the purification of coolant and moderator systems during the normal operation of CANDU (Canada deuterium uranium) nuclear reactors. Carbon-14 is a radionuclide of concern in disposal of ion-exchange resins because of its relatively long half-life, its potential high mobility and its ability to be easily incorporated into organisms. Only limited data are presently available on the 14C concentrations of spent from CANDU reactors. To establish a more comprehensive database for this radionuclide, concentrations of 14C were determined for two moderator resins from Bruce Nuclear Generating Station A. Mixed bed resins were separated into anion and cation fractions using a sugar solution, and the 14C concentrations were determined for each fraction. Carbon-14 was located predominantly in the anion beads. Samples of anion resin were found to undergo an 81% loss in the 14C concentration over a period of 160 d following the sugar separation procedure. Some evidence is given to suggest this loss in 14C may result from microbial activity. Concentrations and distributions of other predominant radionuclides, such as 60Co and 153Gd, are discussed as well. (author) 5 refs.; 2 figs.; 6 tabs

  15. Validation of DRAGON side-step method for Bruce-A restart Phase-B physics tests

    International Nuclear Information System (INIS)

    The DRAGON side-step method, developed at AECL, has a number of advantages over the all-DRAGON method that was used before. It is now the qualified method for reactivity-device calculations. Although the side-step-method-generated incremental cross sections have been validated against those previously calculated with the all-DRAGON method, it is highly desirable to validate the side-step method against device-worth measurements in power reactors directly. In this paper, the DRAGON side-step method was validated by comparison with the device-calibration measurements made in Bruce-A NGS Unit 4 restart Phase-B commissioning in 2003. The validation exercise showed excellent results, with the DRAGON code overestimating the measured ZCR worth by ∼5%. A sensitivity study was also performed in this paper to assess the effect of various DRAGON modelling techniques on the incremental cross sections. The assessment shows that the refinement of meshes in 3-D and the use of the side-step method are two major reasons contributing to the improved agreement between the calculated ZCR worths and the measurements. Use of different DRAGON versions, DRAGON libraries, local-parameter core conditions, and weighting techniques for the homogenization of tube clusters inside the ZCR have a very small effect on the ZCR incremental thermal absorption cross section and ZCR reactivity worth. (author)

  16. 78 FR 3496 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2013-01-16

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 3... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  17. 77 FR 74908 - Maryland Disaster Number MD-00025

    Science.gov (United States)

    2012-12-18

    ... ADMINISTRATION Maryland Disaster Number MD-00025 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  18. Improved Collision Attack on Hash Function MD5

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Xue-Jia Lai

    2007-01-01

    In this paper, we present a fast attack algorithm to find two-block collision of hash function MD5.The algorithm is based on the two-block collision differential path of MD5 that was presented by Wang et al.In the Conference EUROCRYPT 2005.We found that the derived conditions for the desired collision differential path were not sufficient to guarantee the path to hold and that some conditions could be modified to enlarge the collision set.By using technique of small range searching and omitting the computing steps to check the characteristics in the attack algorithm, we can speed up the attack of MD5 efficiently.Compared with the Advanced Message Modification technique presented by Wang et al.,the small range searching technique can correct 4 more conditions for the first iteration differential and 3 more conditions for the second iteration differential, thus improving the probability and the complexity to find collisions.The whole attack on the MD5 can be accomplished within 5 hours using a PC with Pentium4 1.70GHz CPU.

  19. MD on Injection Quality – Longitudinal and Transverse Parameters

    CERN Document Server

    Drosdal, L; Bohl, T; Bracco, C; Cornelis, K; Damerau, H; Goddard, B; Kain, V; Meddahi, M

    2011-01-01

    Losses at injection depend on the beam quality in the longitudinal and transverse plane in the injectors. During the MD on the 30th of June to 1st of July, 2011, many parameters in the injectors were de-tuned on purpose to see the effect on injection losses and hence bring some understanding to recurring problems with injection quality during LHC filling. The effect of the 800 MHz in the SPS, radial steering, larger momentum spread at the SPS extraction and many other longitudinal parameters were studied during the MD. The MD showed however that the injection losses are dominated by far by the transverse size of the particle population. If the SPS scrapers are correctly positioned, injection losses are low even at the presence of quality issues in the longitudinal plane. To be able to inject brighter 50 ns beams or eventually 25 ns beams, injection losses with nominal emittances (3.5 m) must still be acceptable. This MD showed that nominal emittances can be injected with similar loss levels as the typical ...

  20. 76 FR 36447 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-06-22

    ..., 2008, issue of the Federal Register (73 FR 3316). Public meeting We do not now plan to hold a public... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY... a temporary safety zone during the ``NAS Patuxent River Air Expo '11'', which consists of...

  1. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  2. Developmentally regulated expression of two MADS-box genes, MdMADS3 and MdMADS4, in the morphogenesis of flower buds and fruits in apple.

    Science.gov (United States)

    Sung, S K; Yu, G H; Nam, J; Jeong, D H; An, G

    2000-03-01

    Two MADS-box genes, MdMADS3 and MdMADS4, were isolated from the apple (Malus x domestica Borkh.) cultivar Fuji, and their spatial and temporal expression patterns were studied during morphological differentiation of the flower buds and the fruits. Both MdMADS3 and MdMADS4 showed high sequence similarities to FBP2 from petunia, TM5 from tomato, and AGL2, AGL4 from Arabidopsis. Although MdMADS3 was expressed in the inner three whorls of the floral primordium, its expression was hardly detectable in developing fruit. The second gene, MdMADS4, was ubiquitously expressed in the inflorescence meristem, floral meristem, all four floral organs, and fruit. Moreover, MdMADS4 expression was high in the vascular bundles assigned to the floral tube and the carpellary vascular bundles in fruit at early developmental stages. The MdMADS4 transcript also accumulated in embryos of the developing seeds. These results suggest that MdMADS3 and MdMADS4 are involved in different functions, and that MdMADS4 may function in the important events controlling flower and fruit development. PMID:10787044

  3. 基于MD5的迭代散列算法%Iterative Hashing Algorithm Based on MD5

    Institute of Scientific and Technical Information of China (English)

    张青

    2011-01-01

    The paper analyzes the user name and password storage methods and their risks on the internet. On this basis, it analyzes MD5 message digest encryption weaknesses and deciphering means. In response to these decoding methods, it proposes an iterative algorithm based on MD5. This algorithm is immune to the second birthday attack, meanwhile improve the complicates of the the first birthday attack. It is also useful for rainbow table attack. The algorithm can enhance password security features, thereby enhancing the network information transmission and storage security.%分析网络中用户名、密码的存储方式及其存在的风险.在此基础上分析MD5散列算法的弱点及其破译手段.针对这些破泽方法提出基于MD5的迭代散列算法.该算法可以避免第二类生日攻击,并有效提高第一类生日攻击的复杂度,对于破解效率最高的彩虹表也具有免疫性,能够加强密码的安全性能,从而提高网络中信息传递和存储的安全性.

  4. Mitigation of organically bound sulphate from water treatment plants at Bruce NGS and impact on steam generator secondary side chemistry control

    International Nuclear Information System (INIS)

    Bruce Power is the source of more than 20 per cent of Ontario's electricity and currently operates six reactor units at the Bruce Nuclear Generating Station A (two units) and B (four units) stations located on Lake Huron. This paper discusses the challenges faced and operating experience (OPEX) gained in meeting WANO 1.0 chemistry performance objectives for steam generator secondary side chemistry control, particularly with control of steam generator sulphates. A detailed sampling and analysis program conducted as part of this study concluded that a major contributor to steam generator (SG) elevated sulphates is Organically Bound Sulphate (OBS) in Water Treatment Plants (WTP) effluent. The Bruce A and B WTPs consist of clarification with downstream sand and carbon filtration for Lake Water pre-treatment, which are followed by conventional Ion Exchange (IX) demineralization. Samples taken from various locations in the process stream were analyzed for a variety of parameters including both organic bound and inorganic forms of sulphate. The results are inconclusive with respect to finding the definitive source of OBS. This is primarily due to the condition that the OBS in the samples, which are in relatively low levels, are masked during chemical analysis by the considerably higher inorganic sulphate background. Additionally, it was also determined that on-line Total Organic Carbon (TOC) levels at different WTP locations did not always correlate well with OBS levels in the effluent, such that TOC could not be effectively used as a control parameter to improve OBS performance of the WTP operation. Improvement efforts at both plants focused on a number of areas including optimization of clarifier operation, replacement of IX resins, addition of downstream mobile polishing trailers, testing of new resins and adsorbents, pilot-scale testing with a Reverse Osmosis (RO) rig, review of resin regeneration and backwashing practices, and operating procedure improvements

  5. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  6. MD 382: Beam Transfer Function and diffusion mechanisms

    CERN Document Server

    Tambasco, Claudia; Buffat, Xavier; Crouch, Matthew; Pieloni, Tatiana; Boccardi, Andrea; Fuchsberger, Kajetan; Gasior, Marek; Kotzian, Gerd; Lefevre, Thibaut; Pojer, Mirko; Salvachua Ferrando, Belen Maria; Solfaroli Camillocci, Matteo; Giachino, Rossano; CERN. Geneva. ATS Department

    2016-01-01

    The Beam Transfer Function (BTF) measurements have been previously tested in the LHC during MD block 1 and 2. Different machine configurations (i.e. energy, beam intensity, emittance etc...) have been tested to determine a safe set-up (excitation amplitude) of the system to be completely transparent to the beam (no emittance blow-up neither losses). The aim of this experiment in MD block 3 was to characterize the Stability Diagram (SD) in the presence of diffusion mechanisms induced by excited resonances due to beam-beam long range and Landau octupole interplay. During the experiment, BTF measurements have been acquired at flat top for different settings of Landau octupole current, different chromaticity values and transverse feedback gains. In this note the description of the experiment is presented together with some preliminary results.

  7. A Fast Attack Algorithm on the MD5 Hash Function

    Institute of Scientific and Technical Information of China (English)

    WANG Zhang-yi; ZHANG Huan-guo; QIN Zhong-ping; MENG Qing-shu

    2006-01-01

    The sufficient conditions for keeping desired differential path of MD5 was discussed. By analyzing the expanding of subtraction difference, differential characters of Boolean functions, and the differential characters of shift rotation, the sufficient conditions for keeping desired differential path could be obtained. From the differential characters of shift rotation, the lacked sufficient conditions were found. Then an algorithm that reduces the number of trials for finding collisions were presented. By restricting search space, search operation can be reduced tc 234 for the first block and 230 for the second block. The whole attack on the MD5 can be accomplished within 2C hours using a PC with 1.6 G CPU.

  8. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  9. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  10. Analytical applications of MD-FIA-optical detection systems

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A brief introduction of recent research works in our laboratory concerning microdialysis(MD) based on optical detection combined with FIA is made in this mini-review. A biosensor system has been designed and realized the real time in vivo monitoring of some important clinic substances such as calcium, uric acid. The system has also been used to study the in vitro binding of drug-protein.

  11. Application of MD Simulations to Predict Membrane Properties of MOFs

    OpenAIRE

    Elda Adatoz; Seda Keskin

    2015-01-01

    Research Article Application of MD Simulations to Predict Membrane Properties of MOFs Elda Adatoz and Seda Keskin Chemical and Biological Engineering, Koc University, Rumelifeneri Yolu, Sariyer, 34450 Istanbul, Turkey Correspondence should be addressed to Seda Keskin; Received 22 May 2015; Accepted 13 July 2015 Academic Editor: Yanlin Song Copyright © 2015 E. Adatoz and S. Keskin. This is an open access article distributed under the Creative Commons A...

  12. A Secure Hash Function MD-192 With Modified Message Expansion

    OpenAIRE

    Harshvardhan Tiwari; Dr. Krishna Asawa

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which gene...

  13. MD 754: Instability Threshold for Train with 25ns Spacing

    CERN Document Server

    Carver, Lee Robert; Biancacci, Nicolo; Iadarola, Giovanni; Levens, Tom; Metral, Elias; Salvant, Benoit; Wang, Na; CERN. Geneva. ATS Department

    2016-01-01

    Measurements made since the beginning of run II at 6.5 TeV have shown that there is a large discrepancy in the instability thresholds between single bunches and trains of 72 bunches with 25ns spacing, whereas the same result is expect for pure impedance-induced instabilities. One possible explanation is that the presence of electron cloud is affecting the beam stability. This MD will attempt to determine if electron cloud is the dominant mechanism affecting beam stability.

  14. Can maitake MD-fraction aid cancer patients?

    Science.gov (United States)

    Kodama, Noriko; Komuta, Kiyoshi; Nanba, Hiroaki

    2002-06-01

    Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this non-random case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or significant symptom improvement was observed in 58.3 percent of liver cancer patients, 68.8 percent of breast cancer patients, and 62.5 percent of lung cancer patients. The trial found a less than 10-20 percent improvement for leukemia, stomach cancer, and brain cancer patients. Furthermore, when maitake was taken in addition to chemotherapy, immune-competent cell activities were enhanced 1.2-1.4 times, compared with chemotherapy alone. Animal studies have supported the use of maitake MD-fraction for cancer. PMID:12126464

  15. Review of 40-year MD theses in Medical Oncology

    International Nuclear Information System (INIS)

    Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

  16. Structure and Properties of HELICAL CARBON NANOTUBES through MD Simulations

    Science.gov (United States)

    Dahiya, Akshay; Verma, Deepti; Gupta, Shakti S.

    Helical Carbon Nanotubes (HCNTs) are coiled 3-valent carbon networks which represent pure carbon helix. Here we study the geometries of two classes: hexagonal helix containing purely polyhex networks and the second class with 5-and 7-membered rings besides hexagons. We followed a model of hexagonal, single wall HCNTs, and determined their relaxed configuration using MD simulations based on Tersoff potential. A race-track like structure is observed in the cross-section of HCNTs upon minimization. For generating class two helix, the adjacency matrix eigenvector's (AME) method is applied which utilizes 3-coordinated tiling of the plane by 5-,6-,and 7-membered ring for the construction of helical structures. The application of the AME method to torusenes is crucial for class two helix generation as it is based on an appropriate choice of bi-lobial eigenvectors triplet which can be selected on the basis of their nodal properties as verified here. After 3-D transformations the final structure was obtained with the help of MM3-potential based MD simulations on Tinker commercial code. The spring constants of HCNTs are computed through MD simulations.

  17. Implementation of MD5 Fast Decryption Algorithm Based on Graphic Processing Unit%基于GPU的MD5高速解密算法的实现

    Institute of Scientific and Technical Information of China (English)

    乐德广; 常晋义; 刘祥南; 郭东辉

    2010-01-01

    MD5快速碰撞算法由于不支持逆向过程而无法在MD5密码攻击中得到实际应用.针对上述问题,通过分析基于图形处理单元(GPU)的MD5密码并行攻击算法原理,设计基于GPU的MD5高速解密算法,在此基础上实现一个MD5高速密码攻击系统.测试结果证明,该算法能有效加快MD5密码破解速度.

  18. Application of MD5 Algorithm in Database System%MD5算法在数据库系统中的应用

    Institute of Scientific and Technical Information of China (English)

    罗金涛

    2013-01-01

    数据加密是保护数据安全的重要手段,MD5是目前信息安全领域中使用比较广泛的加密算法,对MD5算法的原理进行了分析,并将MD5算法应用在数据库的登录验证过程中.

  19. The Application Research of MD5 Encryption Algorithm in DCT Digital Watermarking

    Science.gov (United States)

    Xijin, Wang; Linxiu, Fan

    This article did the preliminary study of the application of algorithm for MD5 in the digital watermark. It proposed that copyright information will be encrypted using an algorithm MD5, and made rules for the second value image watermarks, through DCT algorithm that embeds an image by the carrier. The extraction algorithms can pick up the watermark and restore MD5 code.

  20. Application of MD5 Encryption Algorithm Based on C# Technology%基于C#技术的MD5加密算法的应用

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    在对Message-Digest Algorithm 5进行简要描述的同时,对MD5算法的原理作深入分析.运用MD5算法,采用目前流行的C#语言进行了具体研究,设计了MD5加密演示系统,经过测试该系统可以准确实现数据的MD5加密.

  1. MD5算法在用户口令认证中的应用%The Application of MD5 Algorithm in The User Password Authentication

    Institute of Scientific and Technical Information of China (English)

    刘洪民; 印帮辉

    2014-01-01

    MD5算法是目前比较安全且易用的加密算法,其在密码领域有着举足轻重的地位.本文通过介绍MD5算法的特点及加密原理,分析了MD5算法在用户口令认证中的安全隐患,给出了用户口令认证应用中如何提高MD5算法安全性的措施和方法.

  2. Computational fluid-structure interaction of axial pipe waves and application towards Bruce 'A' NGS flow-induced feeder vibration - phase I

    International Nuclear Information System (INIS)

    Work was completed which compared predicted fluid-structure interaction results with published experimental results. The model used an impact force to induce stress and pressure waves along a straight pipe which was sealed and filled with pressurized water. Local strain and pressure values at several locations are plotted against time and are presented for visual comparison. The predicted results compare well with the published results and many of the major interaction effects are clearly observable. Application in subsequent work towards Bruce 'A' flow-induced feeder vibration is discussed. (author)

  3. Microbially influenced corrosion (MIC) analyses of the BNGS-B vacuum building. Report No. 92-185-K. [BNGS (Bruce Nuclear Generating Station)

    Energy Technology Data Exchange (ETDEWEB)

    Jain, D.K.

    1992-01-01

    Microbially influenced corrosion (MIC) has been found to play a significant role in causing corrosion, especially in those industries which use natural waters. The most significant of the organisms found to cause corrosion are the sulphate-reducing bacteria (SRB), particularly with anoxic deposits or stagnant weirs. In May 1992, the Bruce Nuclear Generating Station B Vacuum Building was inspected for MIC after being in service for 10 years. This report provides results for both on-site MIC inspection and for microbiological analysis of sediments, water, and slime deposits for evidence of MIC bacteria.

  4. The post irradiation examination of fuel in support of Bruce A nuclear division fueling with flow program

    International Nuclear Information System (INIS)

    Bruce A Nuclear Division (BAND) units are operating at ∼ 75% of full power, because of the potential of a power pulse in the event of an inlet header break. As a result, BAND is converting to fueling with flow, to eliminate the potential of a power pulse and to allow for full-power operation. Concerns regarding the integrity of the end-of-life (EOL) bundles interacting with the latch at the downstream end of the fuel channel were raised. BAND carried out a test program in which EOL bundles in the upstream position 13 of Unit 2 were cascaded into the downstream latch position 1 of another channel. Six of twelve cascaded bundles and two typical EOL position 13 (benchmark) bundles were selected for post-irradiation examination (PIE). Incipient cracks were found in the assembly welds (endplateto-endcap welds) of all six cascaded bundles. No incipient cracks were found in the benchmark bundles. Metallographic and fractographic examination, along with crack dating, and hydrogen and deuterium analyses, indicated that the incipient cracks were the result of delayed-hydride assisted cracking at the EOL. Consequently, Ontario Hydro changed the design of the outlet shield plug to support all three rings of the fuel bundle, to minimize stress and prevent endplate cracking. Also, an ultrasonic endplate inspection tool (UT) was developed and located in the fuel bay. to inspect fuelbundle endplates for cracks. A second test was done involving a series of four bundle cascades in BAND Unit 4 channels that had new outlet shield plugs. The latch bundles were discharged after a hot shutdown. The cascaded Unit 2 and Unit 4 latch bundles were checked for cracks using the UT. The PIE found incipient cracks or less-than-ideal welds in the assembly welds of fuel elements from Unit 2 (latch-supported fuel bundles) that had been identified by the UT as having incipient cracks. No incipient cracks were found in the assembly welds of fuel elements from Unit 4 (new outlet shield

  5. A Secure Hash Function MD-192 With Modified Message Expansion

    CERN Document Server

    Tiwari, Harshvardhan

    2010-01-01

    Cryptographic hash functions play a central role in cryptography. Hash functions were introduced in cryptology to provide message integrity and authentication. MD5, SHA1 and RIPEMD are among the most commonly used message digest algorithm. Recently proposed attacks on well known and widely used hash functions motivate a design of new stronger hash function. In this paper a new approach is presented that produces 192 bit message digest and uses a modified message expansion mechanism which generates more bit difference in each working variable to make the algorithm more secure. This hash function is collision resistant and assures a good compression and preimage resistance.

  6. 散列算法MD5和SHA-1的比较%Comparison between MD5 and SHA-1

    Institute of Scientific and Technical Information of China (English)

    王泽; 曹莉莎

    2016-01-01

    MD5 and SHA-1 are the two known Hash Algorithm which are widely applied in information security, they are both developed from MD4.This paper introduces their algorithm logic in detail, compares them though simulation experiment ,soft-ware testing, etc. Finally, it draw a conclusion:The SHA-1 algorithm is more secure than the MD5 algorithm, but in the same hardware, SHA-1 is slower than MD5.%MD5和SHA-1是两个已知的广泛应用于信息安全的散列算法,均由MD4发展而来。详细介绍了它们的算法逻辑,并通过模拟实验、软件测试等方式对其在各个方面进行比较,最终得出结论:SHA-1算法比MD5算法的安全性更高,但在同一硬件上,SHA-1比MD5运行的要慢。

  7. MD5加密算法的研究及应用%Research and application of MD5 encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    魏晓玲

    2010-01-01

    针对当前网站建设和系统开发中用户信息等重要数据的安全问题,提出了一种MD5加密算法,可以对用户密码进行加密.MD5加密算法是一种比较常用的单向加密算法,通过对该算法的深入研究,介绍了MD5算法的特性、算法原理及其算法流程,并给出MD5算法在一个具体系统中的实际应用,得出MD5算法是一种非常安全和易用的加密算法.

  8. Reverse Crack of MD5 Encryption and Its Safety Improvement%MD5加密逆向破解及安全性改进

    Institute of Scientific and Technical Information of China (English)

    王雄; 朱志祥; 许辉辉

    2014-01-01

    针对消息摘要算法第五版(Message-Digest Algorithm 5,MD5)不可逆的特性,通过组建Oracle明文数据库、调用MD5函数,建立明文与MD5码之间的一一对应关系,实现了对MD5加密的逆向破解.从应对碰撞攻击和反向查询两方面,总结多种改进措施,提高了MD5加密算法在实际应用中的安全性.

  9. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972. PMID:21250499

  10. 基于简化MD5的TFIDF算法%TFIDF Algorithm Based on a Simplified MD5

    Institute of Scientific and Technical Information of China (English)

    刘雅正; 陈受凯; 唐向阳

    2012-01-01

    随着信息技术不断的发展,海量数据的处理效率成为不可逃避的问题.传统的网页分类算法在分类效果上已经相对成熟,所以在这样的背景下从传统网页分类算法中特征值权重算法的效率和代价出发,分析并提出了基于简化MD5的特征值权重算法.有效减少了特征值提取时的比对和最后一次排序的效率,从而提高了整个网页分类的效率.%With the rapid development of information technology, the process efficiency of massive data has become inescapable problem and Web page classification algorithm has matured yet, so from the efficiency and cost of eigenvalue weights algorithm in traditional web page classification algorithm is started. Eigenvalue weights algorithm based on a simplified MD5, and effective in reducing the efficiency of eigenvalue extraction time and the last sort of eigenvalue are analyzed and proposed. Improving the efficiency of the whole Web page classification is presented.

  11. M2-F1 on lakebed with pilots Milt Thompson, Chuck Yeager, Don Mallick, and Bruce Peterson

    Science.gov (United States)

    1963-01-01

    After the initial M2-F1 airtow flights, the NASA Flight Research Center used the vehicle to check out other pilots. Bruce Peterson was scheduled to take over as the M2-F1 project pilot from Milt Thompson, while Don Mallick was to be his backup. Col. (later Brig. Gen.) Charles (Chuck) Yeager, then commandant of the Air Force's Aerospace Research Pilots School, wanted to evaluate a possible lifting-body trainer for the school. This photo shows all of these distinguished pilots on or in the M2-F1, with Col. Yeager in the pilot's seat. The lifting body concept evolved in the mid-1950s as researchers considered alternatives to ballistic reentries of piloted space capsules. The designs for hypersonic, wingless vehicles were on the boards at NASA Ames and NASA Langley facilities, while the US Air Force was gearing up for its Dyna-Soar program, which defined the need for a spacecraft that would land like an airplane. Despite favorable research on lifting bodies, there was little support for a flight program. Dryden engineer R. Dale Reed was intrigued with the lifting body concept, and reasoned that some sort of flight demonstration was needed before wingless aircraft could be taken seriously. In February 1962, he built a model lifting body based upon the Ames M2 design, and air-launched it from a radio controlled 'mothership.' Home movies of these flights, plus the support of research pilot Milt Thompson, helped pursuade the facilities director, Paul Bikle, to give the go-ahead for the construction of a full-scale version, to be used as a wind-tunnel model and possibly flown as a glider. Comparing lifting bodies to space capsules, an unofficial motto of the project was, 'Don't be Rescued from Outer Space--Fly Back in Style.' The construction of the M2-F1 was a joint effort by Dryden and a local glider manufacturer, the Briegleb Glider Company. The budget was $30,000. NASA craftsmen and engineers built the tubular steel interior frame. Its mahogany plywood shell was hand

  12. The cultivar-specific expression patterns of MdACS3 gene and apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks bef...

  13. The role of cultivar-specific expression patterns of MdACS3 gene on apple fruit ripening and quality

    Science.gov (United States)

    Ethylene plays an important role in diverse physiological and developmental processes of plants. In apple, two ethylene biosynthesis genes, MdACS1 and MdACS3, are expressed in fruit tissues. While MdACS1 expresses at late ripening stages, expression of MdACS3 can be detected as early as 6 weeks befo...

  14. The improvement of cryptography MD5 algorithm%密码学中信息摘要算法MD5的改进

    Institute of Scientific and Technical Information of China (English)

    林平

    2011-01-01

    MD5算法的基础上,针对MD5算法密文是一个32位16进制字符来表示值的特征,提出MD5改进算法,首先采用替换加密算法Md5Replace加密MD5算法密文,隐藏MD5算法密文的特征;再选定替换加密密文中某一位置插入由随机函数算法Md5Random产生定长的字符串得到最后的密文,改变了替换加密密文位数,隐藏了替换加密算法替换规律.在不改变算法效率的前提下,提高算法安全强度.

  15. 报文摘要算法MD5的分析与改进

    Institute of Scientific and Technical Information of China (English)

    汪勋亮; 赵春霞; 郭剑辉

    2014-01-01

    MD5算法在数据加密方面有着广泛的应用,但是它无法抵御查字典攻击和差分等攻击。为此本文介绍了报文算法MD5和Base64算法,以及在两种算法的基础上提出了MD5的改进算法,以应对以上被攻击的缺陷。%MD5 encryption algorithm in the data has a wide range of applications,but it can not resist dictionary attacks and differential attacks.This paper introduces the MD5 message digest algorithm and Base64 algorithm,and two algorithms based on the proposed the improved MD5 algorithm,the effect is to deal with the above attack.

  16. Fred Loe, MD, and the history of trachoma.

    Science.gov (United States)

    Feibel, Robert M

    2011-04-01

    Trachoma has been one of the most blinding diseases in the history of ophthalmology. From its initial description in antiquity until the late 1930s, no specific treatment or effective cure had been known, and the only expedient had been to destroy the diseased tissue containing the infectious agent, rendering the disease inactive. Virtually all medical, mechanical, and surgical treatments were unsatisfactory, with cure rates of approximately 20%. Therapy for trachoma had barely advanced from the measures used by the ancient Egyptian, Greek, and Roman physicians. All prior therapies became obsolete in 1938 when Fred Loe, MD, working on an American Indian reservation, introduced sulfanilamide as a treatment of trachoma, achieving a 90% cure rate. One of the most unusual aspects of Loe's career was that he had no formal training in ophthalmology and was completely self-taught as an ophthalmologist. PMID:21482877

  17. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  18. Thermal Sensitivity of MD Hematite: Implication for Magnetic Anomalies

    Science.gov (United States)

    Kletetschka, Gunther; Wasilewski, Peter J.; Taylor, Patrick T.

    1999-01-01

    Magnetic remanence of crustal rocks can reside in three common rock-forming magnetic minerals: magnetite, pyrrhotite, and hematite. Thermoremanent magnetization (TRM) of magnetite and pyrrhotite is carried mostly by single domain (SD) grains. The TRM of hematite grains, however, is carried mostly by multidomain (NM) grains. This characteristic is illustrated by TRM acquisition curves for hematite of variable grainsizes. The transition between truly NM behavior and tendency towards SD behavior his been established between hematite grainsizes of 0. 1 and 0.05 mm. Coarse grainsize of lower crustal rocks and the large sensitivity of MD hematite grains to acquire TRM indicates that hematite could be a significant contributor to long-wavelength magnetic anomalies.

  19. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    and the marginal probabilities can be used directly to assess the significance of the findings. The framework is benchmarked against other methods on a number of real and artificial data sets. The accompanying prediction server, documentation, software, models and data are available from http://bayesmd.binf.ku.dk/.......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...... sampling results are achieved using the advanced sampling method parallel tempering. In a post-analysis step candidate motifs with high marginal probability are found by searching among those motifs that contain sites that occur frequently. Thereby, maximum a posteriori inference for the motifs is avoided...

  20. Plasticity and Failure in Nanocrystalline BCC Metals via MD Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E

    2010-02-12

    Advances in the ability to generate extremely high pressures in dynamic experiments such as at the National Ignition Facility has motivated the need for special materials optimized for those conditions as well as ways to probe the response of these materials as they are deformed. We need to develop a much deeper understanding of the behavior of materials subjected to high pressure, especially the effect of rate at the extremely high rates encountered in those experiments. Here we use large-scale molecular dynamics (MD) simulations of the high-rate deformation of nanocrystalline tantalum at pressures less than 100 GPa to investigate the processes associated with plastic deformation for strains up to 100%. We focus on 3D polycrystalline systems with typical grain sizes of 10-20 nm. We also study a rapidly quenched liquid (amorphous solid) tantalum. We apply a constant volume (isochoric), constant temperature (isothermal) shear deformation over a range of strain rates, and compute the resulting stress-strain curves to large strains for both uniaxial and biaxial compression. We study the rate dependence and identify plastic deformation mechanisms. The identification of the mechanisms is facilitated through a novel technique that computes the local grain orientation, returning it as a quaternion for each atom. This analysis technique is robust and fast, and has been used to compute the orientations on the fly during our parallel MD simulations on supercomputers. We find both dislocation and twinning processes are important, and they interact in the weak strain hardening in these extremely fine-grained microstructures. We also present some results on void growth in nanocrystalline BCC metals under tension.

  1. WEB登录系统中MD5加密算法的PHP实现%PHP Implementation of MD5 Encryption Algorithm in WEB Login System

    Institute of Scientific and Technical Information of China (English)

    王雄; 李旭辉; 许琳华

    2011-01-01

    MD5是web应用程序中常用的加密算法,很多网站的登录模块都采用了MD5加密,用户登录密码通过使用它加密存储到数据库当中,在一定程度上使入侵者不易获得用户登录权限.本文分析比较了中MD5不同的改进算法,并给出了最后的结论.

  2. MD&A – Counterpart to or Distraction from Financial Reporting

    OpenAIRE

    Kevin Girdharry; Elena Simonova; Rock Lefebvre

    2011-01-01

    MD&A content has been an ongoing topic of recent debate with the views divided on the impact that regulated content has on the quality of the MD&A. Complexity has amplified as a result of emerging issues of particular importance to investors such as transition to IFRS, the environment and executive compensation. This paper examines companies’ compliance with requirements of the Canadian Securities Administrators for MD&A disclosures, and aims to advance understand on whether following CSA req...

  3. MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

    Directory of Open Access Journals (Sweden)

    Alja Oblak

    Full Text Available Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in the molecular mechanism of TLR4/MD-2 activation by nickel, as nickel binding site on TLR4 is remote from MD-2, which directly binds the endotoxin as the main pathological activator of TLR4. We identified MD-2 and TLR4 mutants which abolished TLR4/MD-2 receptor activation by endotoxin but could nevertheless be significantly activated by nickel, which acts in synergy with LPS. Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Based on our results we propose that predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation.

  4. The performance of T-pad bearing pads, as a remedy against pressure tube crevice corrosion, on bundles irradiated at Bruce and Point Lepreau

    International Nuclear Information System (INIS)

    Crevice corrosion in CANDU reactors can occur between the standard design fuel bundle bearing pads and the pressure tube when the element operates at a sufficiently high power to create the crevice boiling condition necessary for the concentration of lithium hydroxide leading to enhanced oxidation of the bearing pad and pressure tube. Since crevice corrosion was discovered in Pickering pressure tubes, a concerted effort has been made on design changes to the standard bearing pads in order to minimize/elirninate crevice corrosion. This development program led to the T-Pad bearing pad design. Recent demonstration irradiations of prototype bundles, fitted with T-Pad bearing pads, were conducted in Bruce and Point Lepreau Nuclear Generating Stations. The subsequent post-irradiation examinations indicated, that except for increased hydrogen and deuterium pickup in the T-Pads, the performance of the T-Pads and bundles is consistent with standard bearing pad bundles. (author)

  5. Bruce Travis, La Taifa de Denia et la Méditerranée au XIe siècle, Toulouse, Méridiennes, 2013, 385 p.

    Directory of Open Access Journals (Sweden)

    Dominique Valérian

    2014-01-01

    Full Text Available En s’intéressant à l’histoire de la taifa de Denia, Travis Bruce n’était pas sur un terrain totalement vierge. Plusieurs chercheurs espagnols s’étaient déjà penchés sur cet émirat issu de la dislocation du califat omeyyade d’al-Andalus, et notamment Rafael Azuar Ruiz (1989. Son travail, issu d’une thèse soutenue en 2009 à l’université de Toulouse sous la direction de Philippe Sénac, renouvelle en grande partie ces approches traditionnelles en changeant le cadre et les échelles d’analyse. San...

  6. Iterative redundant encryption based on MD5 algorithm%基于MD5的迭代冗余加密算法

    Institute of Scientific and Technical Information of China (English)

    王津涛; 覃尚毅; 王冬梅

    2007-01-01

    MD5报文摘要算法是一种非常流行的加密方案,是对任意长度的消息提取数字指纹或消息摘要的算法,但是,在计算上难以提供两个具有相同数字指纹的不同消息,并难以由给定的数字指纹推算出相应的消息.基于MD5的迭代冗余加密算法对MD5算法进行了扩展,利用了MD5算法的强大安全性,实现了文件加密、解密和数据完整性保护的功能.

  7. MD5算法的过程分析及其C#实现%Process Analysis of MD5 Algorithm and Its C# realization

    Institute of Scientific and Technical Information of China (English)

    杜昌钰

    2008-01-01

    文章对MD5即"Message-Digest Algorithm 5(报文流行的C#对8D5算法进行了具体的实现,给出了一个具体的C#加密实例.虽然MD5因王小云教授在2004国际密码学会议(Crypto'2004)上发表的论文受到了前所未有的冲击,但MD5在一些非关键领域应用还是相当广泛.最后还提出了一些针对MD5现状的解决对策和建议.

  8. ASP网站用户帐号的MD5加密技术%The Encryption Techniques of MD5 about User Accounts in ASP Web

    Institute of Scientific and Technical Information of China (English)

    田文艳

    2007-01-01

    本文介绍了Asp中的MD5(Message-Digest Algorithm 5)加密技术,分析了它的工作原理及使用过程,并通过具体的使用实例,说明了MD5加密技术在网站开发中的具体实现方法.

  9. A super-high throughput implementation of MD5 algorithm on FPGA%超高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    王臣; 袁焱

    2011-01-01

    In this paper, a novel architecture is proposed to increase the performance of MD5 computing in FPGA , which can achieve a super-high throughput. The scheme is based on full-pipeline for MD5 implementation. Moreover, FIFO cache structure is used for data storage and cooperative computing. The results of simulation and implementation show that the scheme can achieve the theoretical upper bound on throughput. And based on the same platform of FPGA, it outperforms the published scheme with best performance in terms of 77% higher throughput.%为了提高MD5算法在FPGA中实现的运算效率,使之达到超高的数据吞吐量,提出了一种新的全流水线架构,用于实现MD5算法.架构中使用了FIFO缓存存储数据,以配合流水线的运算.实验验证其达到了单个MD5运算单元运算吞吐量的理论上限,在相同芯片平台上,超过已发表的MD5运算模块最高吞吐量的77%.

  10. Design of MD5 High-Speed Models on FPGA%基于FPGA的MD5高速处理模型设计

    Institute of Scientific and Technical Information of China (English)

    韩津生; 林家骏; 叶建武; 周文锦

    2012-01-01

    In order to improve the performance of MD5 on FPGA, the design concept based on dataflow was proposed. At the design phase, it can assess effectively the specific FPGA, the expected system performance and the specific complex algorithms. Three models of MD5 round were put forward and one of the models was chosen to do experiment. The experimental results indicate that the designed MD5 algorithm could increase efficiently the throughput up to 66. 56 Gbit/s.%为提高MD5的处理速度,提出了基于数据流的设计思想.该思想在设计阶段可以对特定的FPGA、预期的系统性能、复杂的专用算法等进行有效评估.基于该思想,提出了3种不同的MD5节点模型.通过分析,对其中1种模型进行实验,实验验证了基于数据流的设计思想能有效提高MD5的吞吐量,达到66.56 Gbit/s.

  11. 一种使MD5算法产生更强雪崩效应的方法%Generating stronger avalanche effect in MD5 algorithm

    Institute of Scientific and Technical Information of China (English)

    张鑫彦; 闫德勤

    2010-01-01

    通过研究不同的差分分析对MD5算法的攻击后发现,差分分析攻击之所以可以成功,是因为在MD5算法中改变了明文中一些特定位,而这些特定位的改变在许多轮中最多只影响链接变量的几个位,并且这些小的差分能在随后的多轮操作中得到纠正,从而产生了碰撞.这就说明原MD5算法的雪崩效应不能阻止差分分析的攻击,而为了提高MD5算法的安全性,必须提高其雪崩效应的敏感性.分析结果表明,用动态明文变化函数对MD5算法进行修改,能使其产生更敏感的雪崩效应,以此来有效防止差分分析攻击,提高MD5算法的安全性.

  12. 78 FR 59060 - Gabriel Sanchez, M.D.; Decision and Order

    Science.gov (United States)

    2013-09-25

    ... any compression of the nerves, or the spinal column, or the nerve root,'' and that it was ``difficult... sufficiently reliable to be accepted and relied upon in this .'' See Cynthia M. Cadet, M.D., 76 FR 19450, 19458... factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003)....

  13. Measurement of Delta-md Using a Probability Based Same-Side Tagger at CDF

    OpenAIRE

    Bauer, G

    2000-01-01

    A measurement of Delta m_d is performed using inclusive lepton+vertex events at CDF. A probability based Same-Side Tagger was developed to tag the initial b-flavor of the B^0_d, which suppresses tagging on B-decay products. We find Delta m_d = 0.42 +/- 0.09 +/- 0.03 ps^-1.

  14. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... have the same design as those installed on Model MD-90-30 airplanes. Therefore, Model MD-90-30..., hangar lighting, flashlight, or ] droplight and may require removal or opening of access panels or...

  15. 77 FR 67673 - Fernando Valle, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-13

    ... DEA registration. Serenity Caf , 77 FR 35027, 35028 (2012); David W. Wang, 72 FR 54297, 54298 (2007); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, M.D., 58 FR 51104 (1993); Bobby Watts, M.D., 53 FR 11919 (1988). Notwithstanding the foregoing, the Respondent contends that the...

  16. DNA methylation fluctuation induced by virus infection differs between MD-resistant and -susceptible chickens

    Science.gov (United States)

    Marek’s disease (MD) is a lymphoproliferative disease induced by Marek’s disease virus (MDV). To augment vaccination, the host genetic resistance is of importance in MD control. While researchers have been largely focused on exploring the genetic differences between resistant and susceptible chicken...

  17. 33 CFR 110.71 - Jacobs Nose Cove, Elk River, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Jacobs Nose Cove, Elk River, Md... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.71 Jacobs Nose Cove, Elk River, Md. The water area of Jacobs Nose Cove, on the west side of the mouth of Elk River, Maryland, comprising the...

  18. Transport and characterization of ambient biological aerosol near Laurel, MD

    Directory of Open Access Journals (Sweden)

    J. L. Santarpia

    2010-09-01

    Full Text Available Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

  19. The MD simulation of thermal properties of plutonium dioxide

    International Nuclear Information System (INIS)

    The thermodynamic properties of PuO2 have been investigated between 300 and 3000 K by molecular dynamics (MD) simulation with empirical interaction potential. The properties include melting point, lattice parameter variation, enthalpy and heat capacity. The melting point of two-phase simulation (TPS) is in agreement with the experimental value, and it gives a much lower value than one-phase simulation (OPS). The lattice parameter and heat capacity at high temperatures are expressed as a(T)=5.38178+4.38×10-5T+6.5525×10-9T2+0.9362×10-12T3 and CP(KJ⋅mol-1⋅K-1)=18648.8e474.5/T/(T2(e474.5/T-1)2)+9.337×10-6T, respectively. True linear thermal expansion coefficient (TLTEC) α is about 8.89×10-6 K-1 at 300 K. Our simulation results are in good agreement with experimental and other theoretical data.

  20. John Call Dalton, Jr., MD: America's first neurophysiologist.

    Science.gov (United States)

    Fine, E J; Manteghi, T; Sobel, S H; Lohr, L A

    2000-09-26

    Before the discoveries of John Call Dalton, Jr., MD (1824-1889), innervation of laryngeal muscles, long-term effects of cerebellar lesions, and consequences of raised intracranial pressure were poorly understood. Dalton discovered that the posterior cricoarytenoid muscles adducted the vocal cords during inspiration. He confirmed Flourens' observations that acute ablation of the cerebellum of pigeons caused loss of coordination. Dalton observed that properly cared for pigeons gradually recovered "coordinating power." Dalton observed that prolonged raised intracranial pressure caused tachycardia and then fatal bradycardia in dogs. Before Dalton published his photographic atlas of the human brain, neuroanatomy atlases were sketched by Europeans and imported into the United States. Dalton's atlas of the human brain contained precise photographs of vertical and horizontal sections that equal modern works. Before Dalton introduced live demonstrations of animals, physiology was taught by recitation of texts only. Dalton was the first American-born professor to teach physiology employing demonstrations of live animals operated on under ether anesthesia. He wrote an essay advocating experimentation on animals as the proper method of acquiring knowledge of function and that humane animal experimentation would ultimately improve the health of man and animals. His eloquent advocacy for humane experimental physiology quelled attacks by contemporaneous antivivisectionists. Dalton was America's first experimental neurophysiologist. PMID:10994009

  1. 基于MD5的可逆无冗余加密算法%The Reversible Non-Redundant Encryption Algorithm Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    陈钧; 刘爱华

    2012-01-01

    If MD5 algorithm is directly used to encrypt sensitive data in database, the data is unable to be deerypted by this algorithm itself, even legitimate users query or update some data for the purpose of restoring data. The database becomes more redundant because secret keys need to be saved for reversible encryption algorithms. This paper proposes a reversible non-redundant encryption algorithm based on MD5 algorithm, which can be ~ to used encrypt and decrypt sensitive data in the database regardless of saving secret keys.%直接采用MD5算法对数据库中的敏感数据加密时,合法用户进行查询、更新等操作需要还原数据,MD5算法无法解密数据.可逆的加密算法都需要保存密钥,数据库增加了数据的冗余.本文提出一种基于MD5算法的可逆无冗余算法,实现对数据库中敏感数据进行加密、解密,而且不需要保存密钥.

  2. MD5算法及在用户口令加密应用中的改进%The Improved MD5 Algorithm in the Encryption of User Passwords

    Institute of Scientific and Technical Information of China (English)

    高洪波; 马素萍

    2010-01-01

    MD5是一种非常优秀的加密算法,曾被大量公司和个人广泛使用.但随着科学技术的发展,MD5牢不可破的神话逐渐破灭.基于此,在分析MD5加密算法及其弱点的前提下,探讨了MD5的改进算法.

  3. The Design of MD5 Algorithm against Exhaustion Code-breaking and Its Realization%MD5算法防穷举(冲撞)破译的设计及其实现

    Institute of Scientific and Technical Information of China (English)

    廖思周

    2006-01-01

    在对MD5算法做简单介绍的基础上,针对攻击者拥有巨大密码字典、原文/密文对照数据库,设计了MD5变换算法,是对现有的MD5算法的延伸,大大提高了现成MD5密文的安全性.

  4. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  5. Criticality safety issues associated with the introduction of low void reactivity fuel in the Bruce reactors - a management and technical overview

    International Nuclear Information System (INIS)

    The concept of criticality for operating reactor staff, particularly in a natural uranium-fuelled reactor, is relatively benign - the reactor is controlled at the critical condition by the regulating system. That is, issues related to criticality exist only within the reactor, in a set of carefully managed circumstances. With the introduction of enriched Low Void Reactivity Fuel (LVRF) into this operating environment comes a new 'concept of criticality', one which, although physically the same, cannot be treated in the same fashion. It may be the case that criticality can be achieved outside the reactor, albeit with a set of very pessimistic assumptions. Such 'inadvertent criticality' outside the reactor, should it occur, cannot be controlled. The consequences of such an inadvertent criticality could have far-reaching effects, not only in terms of severe health effects to those nearby, but also in terms of the negative impact on Bruce Power, and the Canadian nuclear industry in general. Thus the introduction of LVRF in the Bruce B reactors, and therefore the introduction of this new hazard, inadvertent criticality, warrants the development of a governance structure for its management. Such a program will consist of various elements, including the establishment of a framework to administer the criticality safety program, analytical assessment to support the process design, the development of operational procedures, the development of enhanced emergency procedures if necessary, and the implementation of a criticality safety training program. The entire package must be sufficient to demonstrate to station management, and the regulator, that the criticality safety risks associated with the implementation of enriched fuel have been properly evaluated, and that all necessary steps have been taken to effectively manage these risks. A well-founded Criticality Safety Program will offer such assurance. In this paper, we describe the establishment of a Criticality Safety

  6. MD5优化算法及安全性分析%Analysis of MD5 Optimization Algorithm and Safety

    Institute of Scientific and Technical Information of China (English)

    张双斌

    2009-01-01

    针对目前MD5基本算法加密结果容易被破解的问题,在研究分析MD5、SHA-1及其系列算法加密原理的基础上,提出一种增加消息摘要长度的优化算法,使得破解时碰撞的概率减少很多倍,增强了系统加密的安全性.安全分析结果表明,MD5优化算法在保留了原算法加密速度的前提下,具有较原算法更好的抗攻击能力.

  7. A High Throughput FPGA Implementation of MD5 Algorithm%一种高吞吐量MD5算法的FPGA实现

    Institute of Scientific and Technical Information of China (English)

    刘凯; 车明; 秦存秀

    2008-01-01

    MD5数字摘要算法在网络安全的诸多方面都得到广泛的应用.由于其串行计算的特点,对MD5算法的加速并不像其它具有并行操作算法那样容易实现.提出了采用4级流水线的结构来提高MD5运算的吞吐量,可以提升至吉比特级.在设计中,参考了分布式存储模型的结构来实现低延迟、低资源消耗及更好的可扩展性.

  8. Application of MD5 Algorithm in Office Automation System%MD5算法在办公自动化系统中的应用

    Institute of Scientific and Technical Information of China (English)

    张智发

    2008-01-01

    该文对办公自动化系统面临的风险进行了分析,介绍了MD5算法的特点和原理,把MD5算法应用于办公自动化系统中,解决了密码保护、信息完整性验证和数字签名等安全问题, 并给出了具体实现方法.

  9. HMAC-MD5的 FPGA 优化与实现%FPGA Optimization and Implementation of HMAC-MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    蔡啸; 李树国

    2015-01-01

    Data integrity and authenticity are very important in field of information security.HMAC-MD5 algorithm is one of the algorithms that achieve this target.The performance of its software implementation is very low and its FPGA hardware implementation is much higher.For the sake of higher throughput,this paper propose a two-to-one structure.As the result,it costs only 33 cycles to process 5 12 bits data.At the same time,the design support three kinds of mode:HMAC-MD5 computation with Key,HMAC-MD5 computation without key,MD5 computation. The design contains many optimization strategies such as pre-computation, microinstruction controller, the resources reuse etc.After synthesizing by Quartus II 13.0 on Stratix III devices,the clock frequency reaches 100 MHz,the throughput reaches 1.55 Gb/s and 1 120 ALUTs logic resources have been used.%在信息安全领域,数据完整性和真实性是十分重要的.HMAC-MD5算法是实现数据完整性和真实性验证的一种算法.HMAC-MD5的软件实现性能较低,而它的 FPGA 硬件实现性能较高.为了提高 FPGA 实现的性能,提出了一种二合一的结构,处理512 bit 数据周期数降低至33拍,提高了吞吐率,同时能够支持 HMAC-MD5带密钥输入和不带密钥输入、单 MD5运算的模式选择.本设计在 Stratix III 器件上使用 QuartusII 13.0进行综合,在使用了预计算、微指令控制器、资源复用等优化策略之后,最终综合出时钟频率为100 MHz,吞吐率达到1.55 Gb/s,逻辑资源使用为1120 ALUTs.

  10. Authentication in Networking Environment Based on LECC and MD5 Algorithm%基于LECC和MD5算法的网络身份认证

    Institute of Scientific and Technical Information of China (English)

    王小冬; 周海燕

    2015-01-01

    MD5算法常用于对远程用户进行身份认证,但其抵挡不了查字典或差分攻击.本文对用户身份进行MD5加密后,再采用LECC对密文进行纠错编码,提高算法抵御防攻击的能力.理论和实践证明,本算法具有较高的安全性和实用价值.

  11. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  12. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations

    Directory of Open Access Journals (Sweden)

    Celeste R. Vallejo

    2013-11-01

    Full Text Available In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management.

  13. A Mathematic Model That Describes Modes of MdSGHV Transmission within House Fly Populations.

    Science.gov (United States)

    Vallejo, Celeste R; Lee, Jo Ann; Keesling, James E; Geden, Christopher J; Lietze, Verena-Ulrike; Boucias, Drion G

    2013-01-01

    In this paper it is proposed that one potential component by which the Musca domestica salivary gland hypertrophy virus (MdSGHV) infects individual flies is through cuticular damage. Breaks in the cuticle allow entry of the virus into the hemocoel causing the infection. Male flies typically have a higher rate of infection and a higher rate of cuticular damage than females. A model for the transmission of MdSGHV was formulated assuming several potential and recognized means of transmission. The model yields results that are in agreement with field data that measured the infection rate in house flies on dairy farms in Florida. The results from this model indicate that MdSGHV will be maintained at a stable rate within house fly populations and support the future use of MdSGHV as a birth control agent in house fly management. PMID:26462530

  14. 75 FR 49979 - Tony T. Bui, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ....'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I ``may rely on any one or a combination of factors... girlfriend admitting to a soft- drink adulteration that never occurred.'' Id. at 32. Moreover, even after...

  15. 76 FR 52865 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2011-08-24

    ... Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (76 FR 118). We received no... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  16. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  17. EMC/FDTD/MD simulation of carrier transport and electrodynamics in two-dimensional electron systems

    OpenAIRE

    Sule, N; Willis, K. J.; Hagness, S. C.; Knezevic, I.

    2014-01-01

    We present the implementation and application of a multiphysics simulation technique to carrier dynamics under electromagnetic excitation in supported two-dimensional electronic systems. The technique combines ensemble Monte Carlo (EMC) for carrier transport with finite-difference time-domain (FDTD) for electrodynamics and molecular dynamics (MD) for short-range Coulomb interactions among particles. We demonstrate the use of this EMC/FDTD/MD technique by calculating the room-temperature dc an...

  18. Productive replication of Malacosoma neustria nucleopolyhedrovirus (ManeNPV) in Md203 cell line

    OpenAIRE

    DEMİR, İsmail; GÜREL, Nurten; NALÇACIOĞLU, Remziye; İNCE, İkbal A.; DEMİRBAĞ, Zihni

    2009-01-01

    A plaque-purified genotypic variant, derived from a field isolate of the Malacosoma neustria nucleopolyhedrovirus (ManeNPV) from Turkey was characterized based on in vitro replication properties in a cell line, Md203 derived from Malacosoma disstria. The life cycle of ManeNPV was studied based on the cytopathic effects (CPEs), polyhedral inclusion body (PIB) formation, budded virus (BV) production, viral DNA replication and polyhedrin protein expression in ManeNPV-infected Md203 cells. Infec...

  19. MD-CTS: An integrated terminology reference of clinical and translational medicine

    OpenAIRE

    Ray, Will; Finamore, Joe; Rastegar-Mojarad, Majid; Kadolph, Chris; Ye, Zhan; Bohne, Jacquie; Xu, Yin; Burish, Dan; Sondelski, Joshua; Easker, Melissa; Finnegan, Brian; Bartkowiak, Barbara; Smith, Catherine Arnott; Tachinardi, Umberto; Mendonca, Eneida A

    2016-01-01

    New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS). It is the first public resource that comprehensively integrates Wiktionary (word definition), BioPortal (ontology), Wiki (image reference), and Medline abstract (word usage) information. MD-CTS is access...

  20. Parallel cascade selection molecular dynamics (PaCS-MD) to generate conformational transition pathway

    Science.gov (United States)

    Harada, Ryuhei; Kitao, Akio

    2013-07-01

    Parallel Cascade Selection Molecular Dynamics (PaCS-MD) is proposed as a molecular simulation method to generate conformational transition pathway under the condition that a set of "reactant" and "product" structures is known a priori. In PaCS-MD, the cycle of short multiple independent molecular dynamics simulations and selection of the structures close to the product structure for the next cycle are repeated until the simulated structures move sufficiently close to the product. Folding of 10-residue mini-protein chignolin from the extended to native structures and open-close conformational transition of T4 lysozyme were investigated by PaCS-MD. In both cases, tens of cycles of 100-ps MD were sufficient to reach the product structures, indicating the efficient generation of conformational transition pathway in PaCS-MD with a series of conventional MD without additional external biases. Using the snapshots along the pathway as the initial coordinates, free energy landscapes were calculated by the combination with multiple independent umbrella samplings to statistically elucidate the conformational transition pathways.

  1. Five years of FYE: Evolution, outcomes and lessons learned from an institutional program

    OpenAIRE

    Jo McKenzie; Kathy Egea

    2016-01-01

    The University of Technology Sydney First Year Experience program is an institution-wide, systematic approach to supporting the transition, retention and success of first year students from low socio-economic status backgrounds, within a philosophy that good practice for these students is good practice for all students. The program is based on third-generation first year practice and transition pedagogies. It includes central and faculty coordinators, small grants and learning communities ena...

  2. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  3. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  4. Implementation of MD5 Fast Crack Based on GPU Cluster%基于GPU集群实现MD5的快速破解

    Institute of Scientific and Technical Information of China (English)

    杨胜斌

    2013-01-01

    从单个GPU异构并行系统来看,其性能还是比较有限,文章阐述了基于GPU集群的CUDA架构实现过程,详细分析基于GPU集群进行MD5快速破解的编译过程,并对破解程序进行测试研究,对其运行结果进行测试和分析,探讨搭建GPU高性能计算集群及其进行MD5算法的快速破解的过程.

  5. MD5和DES算法在市政网络平台中的应用%Municipal network platform based on md5 funtion and DES algrithm

    Institute of Scientific and Technical Information of China (English)

    邓中亮; 曹其可; 葛悦涛

    2011-01-01

    鉴于市政管理数据中包含大量敏感信息,为解决目前移动终端访问市政平台所存在的安全问题,采用MD5和DES算法,设计一移动通信中间件,对现有的网络进行改进以实现平台的安全机制.MD5算法用采实现身份认证过程,DES算法结合非对称加密和数字签名技术来保证信息的安全传输.该中间件可以以动态库的形式集成在客户端设备与市政管委的Web服务器上,因此可以不需要对现有资源进行较大的改动,以较小的代价达到安全性目标,大大降低部署的难度.%As the database of municipal administration contains large amounts of sensitive information, we designed this mobile middleware to optimized the exsiting platform and protected the sensitive data be attacted. This middleware is based on MD5 and DES algorithm. MD5 algorithm is used to implement the authentication process. DES algorithm combined with asymmetric encryption and digital signature to ensure the safety of information transmission. The middleware can be integrated in the client device and the Web server of the municipal in the form of dynamic libraries. You can achieve the security goals without need to carry out major changes to the existing resources, greatly reduced the difficulty of deployment.

  6. 基于CUDA架构的MD5并行分析算法研究%Research of MD5 Parallel Algorithm Based on CUDA

    Institute of Scientific and Technical Information of China (English)

    张伟; 陈田国; 陶志荣

    2009-01-01

    在介绍了CUDA(统一计算设备架构)架构的基础上,给出了一种CUDA架构上进行MD5摘要分析的并行算法.算法有效利用了GPU的并行性和CUDA架构的优势实现了较快的运算速度,测试结果显示优于CPU的算法.

  7. MD5算法与Web口令的安全传输%MD5 Algorithm and Security Transfer of Web Password

    Institute of Scientific and Technical Information of China (English)

    丁振国; 刘斌

    2004-01-01

    在研究了现存的采用单向散列算法对口令加密传输机制的缺点的基础上,提出了一种用MD5算法加密口令的改进方案,不仅实现简单,而且有效地提高了Web认证系统中口令传输的安全性.

  8. 基于MD5与Base64的混合加密算法%MD5-Base64 based hybrid encryption algorithm

    Institute of Scientific and Technical Information of China (English)

    罗江华

    2012-01-01

    介绍了一种基于MD5和Base64的混合加密算法,首先将明文MD5加密得到32位16进制密文,再将32位密文拆分成16个2位16进制数组,并转换成对应的二进制数,最后将16个二进制数组连接成一个128位的2进制数,采用Base64加密原理进行加密.该算法可以避免查询MD5散列值字典获取用户明文密码,更加有效地保证了用户的密码安全,最后给出了算法的PHP实现.%A MD5-Base64 baaed hybrid encryption algorithm was introduced, which encrypted plain text to 32-bit hexadecimal cipher text by MDS encryption, then split this 32-bit hexadecimal into 16 parts, and transformed them into binary Cor each part to join them together as a 128-bit binary, finally, encrypted the 128-bit binary array by using Base64 algorithm. This algorithm can avoid getting user's clear text password by querying MDS hash database, and protect user's password more effectively. This algorithm was described by PHP script language at the fourth section.

  9. 基于FPGA的MD5算法设计与实现%Design and Implementation of MD5 Algorithm Based on FPGA

    Institute of Scientific and Technical Information of China (English)

    王波涛; 韩国栋; 张效军

    2010-01-01

    MD5算法在网络安全的诸多方面都得到广泛的应用,在一些特殊场合要求计算具有高处理速度,低资源占用率的特点.文中首先介绍了MD5算法的发展历程和算法原理,然后描述了该算法在FPGA上实现的整体架构,分析了其各模块的功能,最后给出了基于Altera公司的Stratix Ⅱ GX系列FPGA的实现结果.通过实验结果可以看出基于FPGA的MD5算法实现具有较高的处理速度和较少的资源占用,并可对设计进行适当修改来实现其它的摘要算法,具有一定的实用价值.

  10. Web开发中MD5摘要计算的应用——Struts技术实现

    Institute of Scientific and Technical Information of China (English)

    鲁屹华

    2008-01-01

    M05的全称是Message-Digest Algorithm 5(信息-摘要算法),在90年代初由MIT Laboratory for Computer Science和RSA Data Security Inc的Ronald L.Rivest开发出来,经MD2、MD3和MD4发展而来.本文首先介绍了MD5算法的概念.然后阐述了Java语言的java.security包对MD5算法的支持,并基于Sun公司Java 2平台企业版(J2EE)MVC框架Struts技术,针对B/S模式毕业设计选题系统中的学生基本信息注册模块所采用的MD5摘要计算作了详细介绍.

  11. The topology of foliations formed by the generic K-orbits of a subclass of the indecomposable MD5-groups

    Institute of Scientific and Technical Information of China (English)

    VU Le Anh; HOA Duong Quang

    2009-01-01

    The paper is a continuation of the authors' works in 2007. We consider the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideals. In this study, we give a topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of R2 and the Connes' C*-algebras of the foliations which come from fibrations are also given.

  12. LHC Transvers Profile Monitors studies (MD on May 6th, 2011)

    CERN Document Server

    Bravin, E; Dehning, B; Emery, J; Lefevre, T; Gras, JJ; Jeff, A; Rabiller, A; Roncarolo, F; Sapinski, M; Kain, V; Pojer, M; Bartosik, H; Salvant, B

    2011-01-01

    This note contains the preliminary results of the LHC MD that took place on 6-May-2011 (from 2 to 10 a.m.), dedicated to study Wire Scanners (WS), Synchrotron Radiation Monitors (BSRT) and Beam Gas Ionization Monitors (BGI). The MD aimed at performing different studies on the individual monitors as well as at cross calibrating them with beams composed of bunches with different transverse emittances in stable conditions. At the same time, it was possible to perform calibration studies with the Abort Gap Monitor (AGM) and Longitudinal Density Monitor (LDM) that share the extracted light with the BSRT.

  13. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools

    OpenAIRE

    Amy Franciscovich; Dhananjay Vaidya; Joe Doyle; Josh Bolinger; Montserrat Capdevila; Marcus Rice; Leslie Hancock; Tanya Mahr; Mogul, Douglas B.

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 an...

  14. Usefulness of multidetector-row CT (MD-CT) for assessment of coronary artery stenosis

    International Nuclear Information System (INIS)

    Coronary arteries stenosis were evaluated in 49 cases by volume rendering (VR) and partial maximum intensity projection (partial MIP) using multidetector-row CT (MD-CT). Left main trunk (LMT) and left anterior descending artery (LAD) were less affected by cardiac pulsation artifact and presented good images. Right coronary artery (RCA) was affected by cardiac pulsation artifact and image quality was inferior as compared to left coronary artery (LCA). It is suggested that MD-CT is useful for assessment of coronary artery stenosis, especially LCA. (author)

  15. Computation of shear viscosity of colloidal suspensions by SRD-MD

    Energy Technology Data Exchange (ETDEWEB)

    Laganapan, A. M. K.; Videcoq, A., E-mail: arnaud.videcoq@unilim.fr; Bienia, M. [SPCTS, UMR 7315, ENSCI, CNRS, Centre Européen de la Céramique, 12 rue Atlantis, 87068 Limoges Cedex (France); Ala-Nissila, T. [COMP CoE at the Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, FIN-00076 Aalto, Espoo (Finland); Department of Physics, Brown University, Providence, Rhode Island 02912-1843 (United States); Bochicchio, D.; Ferrando, R. [Dipartimento di Fisica and CNR-IMEM, via Dodecaneso 33, Genova I-16146 (Italy)

    2015-04-14

    The behaviour of sheared colloidal suspensions with full hydrodynamic interactions (HIs) is numerically studied. To this end, we use the hybrid stochastic rotation dynamics-molecular dynamics (SRD-MD) method. The shear viscosity of colloidal suspensions is computed for different volume fractions, both for dilute and concentrated cases. We verify that HIs help in the collisions and the streaming of colloidal particles, thereby increasing the overall shear viscosity of the suspension. Our results show a good agreement with known experimental, theoretical, and numerical studies. This work demonstrates the ability of SRD-MD to successfully simulate transport coefficients that require correct modelling of HIs.

  16. Composition and syngeneity of molecular fossils from the 2.78 to 2.45 billion-year-old Mount Bruce Supergroup, Pilbara Craton, Western Australia

    Science.gov (United States)

    Brocks, Jochen J.; Buick, Roger; Logan, Graham A.; Summons, Roger E.

    2003-11-01

    Shales of very low metamorphic grade from the 2.78 to 2.45 billion-year-old (Ga) Mount Bruce Supergroup, Pilbara Craton, Western Australia, were analyzed for solvent extractable hydrocarbons. Samples were collected from ten drill cores and two mines in a sampling area centered in the Hamersley Basin near Wittenoom and ranging 200 km to the southeast, 100 km to the southwest and 70 km to the northwest. Almost all analyzed kerogenous sedimentary rocks yielded solvent extractable organic matter. Concentrations of total saturated hydrocarbons were commonly in the range of 1 to 20 ppm (μg/g rock) but reached maximum values of 1000 ppm. The abundance of aromatic hydrocarbons was ˜1 to 30 ppm. Analysis of the extracts by gas chromatography-mass spectrometry (GC-MS) and GC-MS metastable reaction monitoring (MRM) revealed the presence of n-alkanes, mid- and end-branched monomethylalkanes, ω-cyclohexylalkanes, acyclic isoprenoids, diamondoids, tri- to pentacyclic terpanes, steranes, aromatic steroids and polyaromatic hydrocarbons. Neither plant biomarkers nor hydrocarbon distributions indicative of Phanerozoic contamination were detected. The host kerogens of the hydrocarbons were depleted in 13C by 2 to 21‰ relative to n-alkanes, a pattern typical of, although more extreme than, other Precambrian samples. Acyclic isoprenoids showed carbon isotopic depletion relative to n-alkanes and concentrations of 2α-methylhopanes were relatively high, features rarely observed in the Phanerozoic but characteristic of many other Precambrian bitumens. Molecular parameters, including sterane and hopane ratios at their apparent thermal maxima, condensate-like alkane profiles, high mono- and triaromatic steroid maturity parameters, high methyladamantane and methyldiamantane indices and high methylphenanthrene maturity ratios, indicate thermal maturities in the wet-gas generation zone. Additionally, extracts from shales associated with iron ore deposits at Tom Price and Newman have

  17. Green, Bruce H.; And Others

    Science.gov (United States)

    Business Education Forum, 1984

    1984-01-01

    Four short articles discuss the training of those who will eventually own and operate their own businesses or have an opportunity to manage a business for others. They include facts, procedures, and concepts that will aid students in becoming effective members of the business community. (JOW)

  18. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Science.gov (United States)

    2013-05-31

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  19. 76 FR 60873 - Jeffery M. Freesemann, M.D.; Decision and Order

    Science.gov (United States)

    2011-09-30

    ... changes in her ] that he found more ``attractive,'' such as how she was more prone to stay up late and... will not engage in future misconduct. Cf. Ronald Lynch, M.D., 75 FR 78745, 78749 (2010). Order Pursuant.... 52. Galvan told her that around noon he would pick up ``paperwork'' (a term that Det. Boyd...

  20. 75 FR 26993 - Alvin Darby, M.D.; Denial of Application

    Science.gov (United States)

    2010-05-13

    ... dependency on crack cocaine and `primo,' a mixture of cocaine and marijuana smoked together.'' GX 3, at 2... factors are * * * considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR 15227, 15230 (2003). I... application under section 303. See The Lawsons, Inc., 72 FR 74334, 74337 (2007); Anthony D. Funches, 64...

  1. 76 FR 31235 - Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2011-05-31

    ... Ocean City, Maryland. (b) Definition: For purposes of enforcement of this section, Captain of the Port... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Temporary Final rule. SUMMARY: The Coast Guard...

  2. Functional identification of MdSIZ1 as a SUMO E3 ligase in apple.

    Science.gov (United States)

    Zhang, Rui-Fen; Guo, Ying; Li, Yuan-Yuan; Zhou, Li-Jie; Hao, Yu-Jin; You, Chun-Xiang

    2016-07-01

    SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. In Arabidopsis, the AtSIZ1 protein is a SUMO E3 ligase that promotes the conjugation of SUMO proteins to target substrates. Here, we isolated and identified a SUMO E3 ligase, MdSIZ1, in apple, which was similar to AtSIZ1. SUMOylation analysis showed that MdSIZ1 had SUMO E3 ligase activity in vitro and in vivo. SUMO conjugation was increased by high temperatures, low temperatures, and abscisic acid (ABA). The ectopic expression of MdSIZ1 in Arabidopsis siz1-2 mutant plants partially complemented the morphological mutant phenotype and enhanced the levels of SUMO conjugation. Taken together, these results suggest that MdSIZ1-mediated SUMO conjugation of target proteins is an important process that regulates the adaptation of apple plants to various environmental stresses. PMID:27152458

  3. 77 FR 3185 - Proposed Establishment of Class E Airspace; Grasonville, MD

    Science.gov (United States)

    2012-01-23

    ... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... Grasonville, MD, providing the controlled airspace required to support the Copter RNAV GPS special...

  4. 77 FR 22523 - Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2012-04-16

    ... Federal Register (73 FR 3316). ] Public Meeting We do not now plan to hold a public meeting. But you may... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; 2012 Ocean City Air Show; Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  5. 78 FR 76322 - Thomas Neuschatz, M.D.; Decision and Order

    Science.gov (United States)

    2013-12-17

    ... of J.G.'s known addiction, ``but inaccurately represented this as a treatment for a chronic pain... her chronic pain rather than as treatment for her opioid addiction was patently false.'' Id. at 18...(f). ``These factors are . . . considered in the disjunctive.'' Robert A. Leslie, M.D., 68 FR...

  6. 77 FR 45675 - Margy Temponeras, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ... that Mrs. Leadingham similarly stated that ``she was there to dispense the medication and put the... medication to patients.'' (Id.) The location was described as having the doctor's office on the left of the... encompasses the factors listed in Section 824(a).'' ALJ at 19 n.24 (citing Kuen H. Chen, M.D., 58 FR...

  7. Novel plasmid conferring kanamycin and tetracycline resistance in turkey-derived Campylobacter jejuni strain 11601MD

    Science.gov (United States)

    In Campylobacter spp., resistance to the antibiotics kanamycin and tetracycline is frequently associated with plasmid-borne genes. However, relatively few plasmids of Campylobacter jejuni have been fully characterized to date. A novel plasmid (p11601MD; 44,095 bp.) harboring tet(O) was identified in...

  8. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows... Avenue) highway toll drawbridge across Bear Creek, mile 1.5, Sparrows Point, MD was replaced with a fixed... Bear Creek, mile 1.5 was removed and replaced with a fixed bridge in 1998. Prior to 1998, a...

  9. 77 FR 23599 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-04-20

    ... regulations to the Small Business and Agriculture Regulatory Enforcement Ombudsman and the Regional Small...; Potomac River, Charles County, MD'' in the Federal Register (77 FR 27). We received one comment on the... substantial number of small entities. The term ``small entities'' comprises small businesses,...

  10. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2)

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  11. Draft Genome Sequence of Lactobacillus jensenii Strain MD IIE-70(2).

    OpenAIRE

    Karlyshev, Andrey V.; Nadarajah, Sindhujan; Abramov, Vyacheslav M.

    2013-01-01

    A draft genome sequence of Lactobacillus jensenii strain MD IIE-70(2) was determined using Ion PGM technology. The reads were mapped to a reference strain and assembled using a combination of tools. The genetic features revealed in this study will assist in understanding the probiotic properties of Lactobacillus bacteria.

  12. 78 FR 76169 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Final Comprehensive...

    Science.gov (United States)

    2013-12-16

    .... Geological Survey (USGS) Patuxent Wildlife Research Center, a leading international research institute for... Fish and Wildlife Service Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD... significant impact (FONSI) for Patuxent Research Refuge (Patuxent RR, refuge), located in Prince George's...

  13. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast...

  14. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  15. Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes.

    Science.gov (United States)

    Yeo, Tae Yun; Choi, Ji Suk; Lee, Byung Kook; Kim, Beob Soo; Yoon, Hwa In; Lee, Hyeong Yun; Cho, Yong Woo

    2011-10-15

    Even low concentrations of endotoxins can be life-threatening. As such, continuous effort has been directed toward the development of sensitive and specific endotoxin detection systems. In this paper, we report the design and fabrication of a new electrochemical endotoxin sensor based on a human recombinant toll-like receptor 4 (rhTLR4) and myeloid differentiation-2 (MD-2) complex. The rhTLR4/MD-2 complex, which specifically binds to endotoxin, was immobilized on gold electrodes through a self-assembled monolayer (SAM) technique involving the use of dithiobis(succinimidyl undecanoate) (DSU). The surface topography of the electrodes at each fabrication stage was characterized with a nanosurface profiler and atomic force microscope (AFM). The electrochemical signals generated from interactions between the rhTLR4/MD-2 complex and the endotoxin were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). A linear relationship between the peak current and endotoxin concentration was obtained in the range of 0.0005 to 5 EU/mL with a correlation coefficient (R(2)) of 0.978. The estimated limit of detection (LOD) was fairly low, 0.0002 EU/mL. The rhTLR4/MD-2 based sensors exhibited no current responses to dipalmitoylphosphatidylcholine (DPPC) bearing two lipid chains, which is structurally similar to endotoxin, indicating the high specificity of the sensors to endotoxin. PMID:21816600

  16. 75 FR 41789 - Special Local Regulations for Marine Events; Patuxent River, Solomons, MD

    Science.gov (United States)

    2010-07-19

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public Meeting We do... for Marine Events; Patuxent River, Solomons, MD'' in the Federal Register (75 FR 111). The NPRM stated... Solomon's Pier. A large spectator fleet is expected during the event. Due to the need for vessel...

  17. Identification of key residues that confer Rhodobacter sphaeroides LPS activity at horse TLR4/MD-2.

    Directory of Open Access Journals (Sweden)

    Katherine L Irvine

    Full Text Available The molecular determinants underpinning how hexaacylated lipid A and tetraacylated precursor lipid IVa activate Toll-like receptor 4 (TLR4 are well understood, but how activation is induced by other lipid A species is less clear. Species specificity studies have clarified how TLR4/MD-2 recognises different lipid A structures, for example tetraacylated lipid IVa requires direct electrostatic interactions for agonism. In this study, we examine how pentaacylated lipopolysaccharide from Rhodobacter sphaeroides (RSLPS antagonises human TLR4/MD-2 and activates the horse receptor complex using a computational approach and cross-species mutagenesis. At a functional level, we show that RSLPS is a partial agonist at horse TLR4/MD-2 with greater efficacy than lipid IVa. These data suggest the importance of the additional acyl chain in RSLPS signalling. Based on docking analysis, we propose a model for positioning of the RSLPS lipid A moiety (RSLA within the MD-2 cavity at the TLR4 dimer interface, which allows activity at the horse receptor complex. As for lipid IVa, RSLPS agonism requires species-specific contacts with MD-2 and TLR4, but the R2 chain of RSLA protrudes from the MD-2 pocket to contact the TLR4 dimer in the vicinity of proline 442. Our model explains why RSLPS is only partially dependent on horse TLR4 residue R385, unlike lipid IVa. Mutagenesis of proline 442 into a serine residue, as found in human TLR4, uncovers the importance of this site in RSLPS signalling; horse TLR4 R385G/P442S double mutation completely abolishes RSLPS activity without its counterpart, human TLR4 G384R/S441P, being able to restore it. Our data highlight the importance of subtle changes in ligand positioning, and suggest that TLR4 and MD-2 residues that may not participate directly in ligand binding can determine the signalling outcome of a given ligand. This indicates a cooperative binding mechanism within the receptor complex, which is becoming increasingly

  18. 基于C#技术的MD5加密算法设计与实现%Design and Implementation of MD5 Algorithm Based on C# Technology

    Institute of Scientific and Technical Information of China (English)

    王倩丽

    2010-01-01

    本文对Message-Digest Algorithm 5(信息-摘要算法)进行了简要描述,并对MD5算法的原理进行了深入分析.同时采用目前流行的C#语言对MD5算法进行了具体的应用,实现了MD5加密演示系统.虽然MD5算法因王小云教授在2004国际密码学会议上发表的论文引起了很大的反响,但MD5算法仍然在数字签名、电子商务、信息加密等领域中有着非常广泛的应用.

  19. MD5 Encryption Algorithm and its Application in NETPRO Protocol%MD5加密算法及其在NETPRO协议中的应用

    Institute of Scientific and Technical Information of China (English)

    王大志; 马良

    2005-01-01

    短信网关系统中,内容提供商与网关之间通信采用客户机/服务器(C/S)模式,网关通过NETPRO协议与内容提供商通信.网络安全问题变得非常突出,对于用户密码等敏感信息,应该有一种能有效防止被轻易截获的方法来保护.MD5加密算法就是这种设想的强有力的工具.

  20. Registration of the Soft Red Winter Wheat Germplasm MD01W233-06-1 Resistant to Fusarium Head Blight

    Science.gov (United States)

    MD01W233-06-1 (Reg. No., PI ) is a soft red winter wheat (SRWW) (Triticum aestivum L.) germplasm line developed at the University of Maryland and released by the Maryland Agricultural Experiment Station in 2009. MD01W233-06-1 was selected from a cross of ‘McCormick’/ ‘Choptank’ made in 2001. McCorm...

  1. 77 FR 9228 - AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Science.gov (United States)

    2012-02-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission AP Gas & Electric (MD), LLC; Supplemental Notice That Initial Market-Based... above-referenced proceeding of AP Gas & Electric (MD), LLC's application for market-based rate...

  2. Draft Genome Sequence of Ralstonia sp. MD27, a Poly(3-Hydroxybutyrate)-Degrading Bacterium, Isolated from Compost

    OpenAIRE

    Zhu, Morgan; McCully, Lucy M.; Silby, Mark W; Charles-Ogan, Tamunonengiyeofori I.; Huang, Jean; Brigham, Christopher J.

    2015-01-01

    Ralstonia sp. strain MD27, a novel biopolymer-degrading betaproteobacterium, was isolated from compost samples. This organism has been shown to utilize the biopolymer poly(3-hydroxybutyrate) [P(3HB)] as a carbon source for growth. We report the draft genome sequence of MD27 with an estimated total sequence length of 5.9 Mb.

  3. 33 CFR 165.556 - Regulated Navigation Area; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD.

    Science.gov (United States)

    2010-07-01

    ... areas, found in 33 CFR 165.13, apply to the regulated navigation area described in paragraph (a) of this...; Chesapeake and Delaware Canal, Chesapeake City Anchorage Basin, MD. 165.556 Section 165.556 Navigation and..., Chesapeake City Anchorage Basin, MD. (a) Location. The following area is a regulated navigation area:...

  4. Bioaccumulation of radioactive uranium-series constituents from the environment (BRUCE): a tool for estimating radionuclide transfer to Northern Australia bushfoods and ingestion doses to members of the public

    International Nuclear Information System (INIS)

    The Alligator Rivers Region in Northern Australia is an area of past and present uranium mining activity. It is also an area of customary bushfood harvesting by local Aboriginal people for sustenance. Commonly harvested bushfoods include native fruits and root vegetables and the flesh and organs of animals from terrestrial and freshwater environments. The consumption of bushfoods from uranium mine impacted areas in the Alligator Rivers Region is a potential radiation exposure pathway for members of the public, both now and in the future. Assessment of potential ingestion doses via this pathway requires information on bushfood radionuclide content. This information may be elicited through direct measurement or through knowledge of the environmental transfer of radionuclides to bushfoods. BRUCE is a database for the storage and handling of data on natural-series radionuclide concentrations in Northern Australian bushfoods and environmental media samples. It contains more than 2000 individual records, representing more than 25 years of measurements by the Supervising Scientist Division. Query functions within BRUCE enable the calculation of statistical information on concentration ratios for radionuclide transfer to Northern Australian bushfoods and the calculation of ingestion doses to members of the public using information on local diet and intake dose conversion factors recommended by the International Commission on Radiological Protection. Although not specifically setup for the non-human environment, the transfer query function may be useful in determining organism-to-media concentration ratios for some organism types for use in non-human biota dose assessment tools such as ERICA and RESRAD-BIOTA.

  5. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    Science.gov (United States)

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  6. MdMYB1 Regulates Anthocyanin and Malate Accumulation by Directly Facilitating Their Transport into Vacuoles in Apples.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Ma, Qi-Jun; You, Chun-Xiang; Cheng, Lailiang; Hao, Yu-Jin

    2016-03-01

    Tonoplast transporters, including proton pumps and secondary transporters, are essential for plant cell function and for quality formation of fleshy fruits and ornamentals. Vacuolar transport of anthocyanins, malate, and other metabolites is directly or indirectly dependent on the H(+)-pumping activities of vacuolar H(+)-ATPase (VHA) and/or vacuolar H(+)-pyrophosphatase, but how these proton pumps are regulated in modulating vacuolar transport is largely unknown. Here, we report a transcription factor, MdMYB1, in apples that binds to the promoters of two genes encoding the B subunits of VHA, MdVHA-B1 and MdVHA-B2, to transcriptionally activate its expression, thereby enhancing VHA activity. A series of transgenic analyses in apples demonstrates that MdMYB1/10 controls cell pH and anthocyanin accumulation partially by regulating MdVHA-B1 and MdVHA-B2. Furthermore, several other direct target genes of MdMYB10 are identified, including MdVHA-E2, MdVHP1, MdMATE-LIKE1, and MdtDT, which are involved in H(+)-pumping or in the transport of anthocyanins and malates into vacuoles. Finally, we show that the mechanism by which MYB controls malate and anthocyanin accumulation in apples also operates in Arabidopsis (Arabidopsis thaliana). These findings provide novel insights into how MYB transcription factors directly modulate the vacuolar transport system in addition to anthocyanin biosynthesis, consequently controlling organ coloration and cell pH in plants. PMID:26637549

  7. MD5算法在档案管理系统中的应用%Application of MD5 Algorithm in File Management System

    Institute of Scientific and Technical Information of China (English)

    徐宝清; 赵乾宗

    2015-01-01

    along with the country to the information development and the culture education the increasing attention, the file man⁃agement system is becoming more and more popular. At the same time, with the increase of the amount of archives and the amount of users, the file management system is developing towards more automatic and humane direction.. In order to make the system more accord with the safety standards, the system will use MD5 encryption algorithm for user identity authentication.%随着国家对信息化发展和文化教育的日益重视,档案管理系统正变得越来越普及。与此同时,伴随着档案量和用户量的不断增加,档案管理系统也向着更加自动化和人性化的方向发展。为了使系统更加符合安全标准,系统将采用MD5加密算法对用户身份进行有效认证。

  8. Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.

    Science.gov (United States)

    Su, S; Cui, N; Li, J; Sun, P; Li, H; Li, Y; Cui, Z

    2016-07-01

    Marek's disease virus (MDV) GX0101 is a field strain of MDV with a naturally occurring insertion of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) fragment. Both copies of the meq gene were knocked out in the GX0101 bacterial artificial chromosome (BAC) clone to construct the recombinant virus SC9-1, resulting in a complete lack of pathogenicity and providing better protection against MD than CVI988/Rispens. In the present study, the BAC sequences in SC9-1 were removed using a cre-loxP system, and the virus termed SC9-2. SC9-2 showed a significant increase in replication in vitro and in vivo. There was a significant decrease in chicken weight, immune organ index, and antibody levels compared with those of SC9-1-inoculated chickens. The immune protection index of SC9-2 was similar to that of SC9-1, and the difference was not significant. The results of our studies demonstrate that the SC9-2 virus provides protection in specific pathogen free (SPF) chickens when challenged with a very virulent MDV rMd5, but it induces immunosuppressive effects in SPF chickens. PMID:26957626

  9. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Science.gov (United States)

    Franciscovich, Amy; Vaidya, Dhananjay; Doyle, Joe; Bolinger, Josh; Capdevila, Montserrat; Rice, Marcus; Hancock, Leslie; Mahr, Tanya; Mogul, Douglas B

    2015-01-01

    Biliary atresia (BA) is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa) was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%). The specificity was 24/27 (89%) with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48) and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83). kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light settings. PoopMD

  10. PoopMD, a Mobile Health Application, Accurately Identifies Infant Acholic Stools.

    Directory of Open Access Journals (Sweden)

    Amy Franciscovich

    Full Text Available Biliary atresia (BA is the leading cause of pediatric end-stage liver disease in the United States. Education of parents in the perinatal period with stool cards depicting acholic and normal stools has been associated with improved time-to-diagnosis and survival in BA. PoopMD is a mobile application that utilizes a smartphone's camera and color recognition software to analyze an infant's stool and determine if additional follow-up is indicated. PoopMD was developed using custom HTML5/CSS3 and wrapped to work on iOS and Android platforms. In order to define the gold standard regarding stool color, seven pediatricians were asked to review 45 photographs of infant stool and rate them as acholic, normal, or indeterminate. Samples for which 6+ pediatricians demonstrated agreement defined the gold standard, and only these samples were included in the analysis. Accuracy of PoopMD was assessed using an iPhone 5s with incandescent lighting. Variability in analysis of stool photographs as acholic versus normal with intermediate rating weighted as 50% agreement (kappa was compared between three laypeople and one expert user. Variability in output was also assessed between an iPhone 5s and a Samsung Galaxy S4, as well as between incandescent lighting and compact fluorescent lighting. Six-plus pediatricians agreed on 27 normal and 7 acholic photographs; no photographs were defined as indeterminate. The sensitivity was 7/7 (100%. The specificity was 24/27 (89% with 3/27 labeled as indeterminate; no photos of normal stool were labeled as acholic. The Laplace-smoothed positive likelihood ratio was 6.44 (95% CI 2.52 to 16.48 and the negative likelihood ratio was 0.13 (95% CI 0.02 to 0.83. kappauser was 0.68, kappaphone was 0.88, and kappalight was 0.81. Therefore, in this pilot study, PoopMD accurately differentiates acholic from normal color with substantial agreement across users, and almost perfect agreement across two popular smartphones and ambient light

  11. MD-portal: Highly Effective Website for Nuclear Materials Information Management

    International Nuclear Information System (INIS)

    A web-based system is widespread in not only everyday activities but also business fields. In past years, the systematic information of various properties of materials usually has been provided as tabulated documents; however it recently has been provided as web-based DB. There are many websites providing material properties information, representative examples include MatWeb from the United States, Granta MI from England and MatNavi from Japan. In 2003, the nuclear materials division in KAERI established a website about nuclear materials property DB, called MatDB. To inherit it, a website called MD-portal has been recently set up to release degradation information and various properties of nuclear materials. In this presentation, the structure and characteristics of MD-portal will be mentioned, and comments on its application will be given

  12. Role of Calcium Ion in Apoptosis of MD Cancer Cells Induced by Arsenic Trioxide

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jiuli; WANG Jintao; XU Shiwen

    2008-01-01

    In order to observe the role of calcium ion in apoptosis of MD cancer cells induced by arsenic trioxide, inhibition percentage was detected by MTT assay;morphology changes were examined by fluorescence microscope;apoptosis was examined by DNA Ladder;[Ca2+]i was investigated by spectrofluorimeter in vitro on MDCC-MSB1 cells. The results showed that As2O3 inhibited the proliferation of MDCC-MSB1 cells in concentration dependent manner (P<0.05 or P<0.01);typical apoptosis character was observed by fluorescence microscope;DNA Ladder was observed;the [Ca2+]i was elevated significantly after the treatment of As203 (P<0.05 or P<0.01) and showed a dose-dependent manner. It is concluded that the calcium may play an important role in apoptosis of MD cancer cells induced by arsenic trioxide.

  13. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB)

    CERN Document Server

    Morisset, Christophe; Flores-Fajardo, Nahiely

    2014-01-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (Planetary Nebulae, H II regions, etc). Grid of models are performed to understand what are the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort of resolving both of these issues in the form of a database of photoionization models, easily accessible throught the MySQL protocol, and containing a lot of usefull outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  14. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    OpenAIRE

    Ravel, Jacques; Mazmanian, Sarkis K.

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research...

  15. Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

    International Nuclear Information System (INIS)

    Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

  16. MD/MBA Students: An Analysis of Medical Student Career Choice

    OpenAIRE

    Sherrill, Windsor Westbrook

    2009-01-01

    Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Me...

  17. Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

    International Nuclear Information System (INIS)

    The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

  18. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  19. A unified architecture of MD5 and RIPEMD-160 hash algorithms

    OpenAIRE

    Ng, CW; Ng, TS; Yip, KW

    2004-01-01

    Hash algorithms are important components in many cryptographic applications and security protocol suites. In this paper, a unified architecture for MD5 and RIPEMD-160 hash algorithms is developed. These two algorithms are different in speed and security level. Therefore, a unified hardware design allows applications to switch from one algorithm to another based on different requirements. The architecture has been implemented using Altera's EPF10K50SBC356-1, providing a throughput over 200Mbit...

  20. Measurement of the Mass Difference m(D_s^+) - m(D^+) at CDF II

    CERN Document Server

    Acosta, D; Ahn, M H; Akimoto, T; Albrow, M G; Alcorn, B; Alexander, C; Allen, D; Allspach, D H; Amaral, P; Ambrose, D; Amendolia, S R; Amidei, D; Amundson, J F; Anastassov, A; Anderson, J; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Asakawa, T; Ashmanskas, W; Attal, A; Avanzini, C; Azfar, F; Azzi-Bacchetta, P; Babik, M; Bacchetta, N; Bachacou, H; Badgett, W F; Bailey, S; Bakken, J; Barbaro-Galtieri, A; Bardi, A; Bari, M; Barker, G; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Barsotti, E; Basti, A; Bauer, G; Beckner, D; Bedeschi, F; Behari, S; Belforte, S; Bell, W H; Bellendir, G; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Berg, B; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bogdan, M; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bowden, M; Box, D; Bromberg, C; Brown, W; Brozovic, M; Brubaker, E; Buckley-Geer, L; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byon-Wagner, A; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canal, P; Canepa, A; Carithers, W C; Carlsmith, D; Carosi, R; Carrell, K; Carter, H; Caskey, W; Castro, A; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chandler, J T; Chapman, J; Chappa, S; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Cisko, S; Clark, A G; Coca, M; Coiley, K; Colijn, A P; Colombo, R M; Connolly, A; Convery, M; Conway, J; Cooper, G; Cordelli, M; Cortiana, G; Cranshaw, J; Cudzewicz, R; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Dal Monte, L; Da Ronco, S; D'Auria, S; Davila, R; Dawson, J; Dawson, T; De Barbaro, P; De Baun, C; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; De Maat, R; Demar, P; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Derylo, G; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donno, F; D'Onofrio, M; Dorigo, T; Downing, R; Drake, G; Drennan, C; Drollinger, V; Dunietz, Isard; Dyer, A; Ebina, K; Eddy, N; Ely, R; Engels, E; Erbacher, R D; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Fischler, M; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fromm, J; Fujii, Y; Furic, I; Galeotti, S; Galet, G; Gallas, A; Gallinaro, M; Ganel, O; García, C; García-Sciveres, M; Garfinkel, A F; Garwacki, M; Garzoglio, G; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Gerstenslager, J; Giacchetti, L; Giagu, S; Giannetti, P; Gibson, A; Gillespie, G; Gingu, C; Ginsburg, C; Giolo, K; Giordani, M; Glagolev, V; Glenzinski, D A; Glossen, R; Gold, M; Goldschmidt, N; Goldstein, D B; Goldstein, J; Gómez, G; Goncharov, M; González, H; Gordon, S; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Grado, J; Gregori, M; Gresele, A; Griffin, T; Grim, G; Grimm, C; Gromoll, S; Grosso-Pilcher, C; Gu, C; Guarino, V; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, A; Hahn, K; Hahn, S R; Halkiadakis, E; Hall, C; Handler, R; Haney, M; Hao, W; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington, J; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hawke, T; Hays, C; Heider, E; Heinemann, B; Heinrich, J; Heiss, A; Hennecke, M; Herber, R; Herndon, M; Herren, M; Hicks, D; Hill, C; Hirschbuehl, D; Höcker, A; Hoff, J; Hoffman, K D; Hoftiezer, J H; Holloway, A; Holloway, L E; Holm, S; Holmgren, D; Hou, S; Houlden, M A; Howell, J; Hrycyk, M; Hubbard, P; Hughes, R E; Huffman, B T; Humbert, J; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, I; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jetton, R; Johnson, M; Jones, M; Jones, T; Jun, S Y; Junk, T R; Kallenbach, Jeff; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kasha, H; Kasten, M; Kato, Y; Kemp, Y; Kennedy, R D; Kephart, K; Kephart, R D; Khazins, D; Khotilovich, V; Kilminster, B; Kim, B J; Kim, D H; Kim, H S; Kim, J; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirk, M; Kirsch, L; Klein, R; Klimenko, S; Knapp, M; Knoblauch, D; Knuteson, B; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kononenko, W; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A; Kovalev, A; Kowalkowski, J B; Kraus, J; Kravchenko, I V; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kumar, A; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lamore, D; Lancaster, J; Lancaster, M; Lander, R; Lanfranco, G; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lee, J; Lee, K; Lee, S W; Lei, C M; Leininger, M; Leonardi, G L; Leonardo, N; Leone, S; Levshina, T; Lewis, F; Lewis, J D; Li, K; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lobban, O; Lockyer, N S; Loginov, A; Loken, J; Loreti, M; Loskot, J; Loverre, P F; Lucchesi, D; Lukens, P; Lutz, P; Lyons, L; Lys, J; MacNerland, J; MacQueen, D; Madorsky, A; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Mammini, P; Manca, G; Mandrichenko, I V; Manea, C; Marginean, R; Marrafino, J; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mayer, J; Mayers, G M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Meyer, A; Miao, T; Michael, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Mizicko, D; Moccia, S; Moggi, A; Moggi, N; Montero, S; Moore, R; Moore, T; Morris, L; Morsani, F; Moulik, T; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Murgia, S; Nachtman, J; Nagaslaev, V; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Neuberger, D; Newby, W; Newcomer, F M; Newman-Holmes, C; Niell, F; Nielsen, J; Nicollerat, A S; Nigmanov, T; Niu, H; Nodulman, L; Noe, W; Österberg, K; Ogawa, T; Oh, S; Oh, Y D; Ohl, K; Ohsugi, T; Oishi, R; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Orr, S; Pagani, G; Pagliarone, C; Palmonari, F; Ramos, I; Panacek, S; Pantano, D; Paoletti, R; Papadimitriou, V; Pasetes, R; Pashapour, S; Passuello, D; Paterno, M; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pavlicek, V; Pavlon, S; Pellett, D; Penzo, Aldo L; Perington, B; Petragnani, G; Petravick, D; Phillips, T J; Photos, F; Piacentino, G; Picciolo, C; Piccoli, L; Piedra, J; Pitts, K T; Plunkett, R; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Profeti, A; Pronko, A G; Proudfoot, J; Punzi, G; Rademacker, J; Rafaelli, F; Rakitine, A; Rappoccio, S; Ratnikov, F; Rauch, J; Ray, H; Rechenmacher, R; Reia, S; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Riveline, M; Rivetta, C; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Román, M; Rosenberg, S I; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Sabik, S; Sadler, L; Safonov, A; Saint-Denis, R; Sakumoto, W K; Saltzberg, D; Sánchez, C; Sanders, H; Sanders, R; Sandrew, M; Sansoni, A; Santi, L; Sarkar, S; Sarraj, H; Sarraj, J; Sato, H; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, J; Schmidt, M P; Schmitt, M; Schmitt, R; Schmitz, M; Schofield, G L; Schuh, K; Schultz, K; Scodellaro, L; Scott, L; Scribano, A; Scuri, F; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shallenberger, J; Shapiro, M D; Shaw, T; Shears, T G; Shenai, A; Shepard, P F; Shimojima, M; Shochet, M J; Shon, Y; Shoun, M; Sidoti, A; Siegrist, J L; Sieh, C; Siket, M; Sill, A; Silva, R; Simaitis, V; Sinervo, P; Sirotenko, V I; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Stadie, H; Stanek, R; Stanfield, N; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Stuermer, W; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Syu, J; Szymulanski, A; Taffard, A C; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tamburello, P; Tanaka, M; Tanaka, R; Tang, D; Tanimoto, N; Tannenbaum, B; Tapprogge, Stefan; Taylor, R D; Teafoe, G; Tecchio, M; Teng, P K; Terashi, K; Terentieva, T; Tesarek, R J; Tether, S; Thom, J; Thomas, A; Thompson, A S; Thomson, E; Thurman-Keup, R M; Timm, S; Tipton, P; Tkaczyk, S M; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torretta, D; Trimby, C; Trischuk, W; Trumbo, J; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, T; Van Berg, R; Varganov, A V; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vittone, M; Voirin, J; Vollmer, B; Vollrath, I; Volobuev, I P; Von der Mey, M; Votava, M; Wagner, R G; Wagner, R L; Wagner, W; Wallace, N; Walter, T; Walters, A; Wan, Z; Wandersee, A; Wang, M J; Wang, S M; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Weems, L; Wenzel, H; Wester, W; Whitehouse, B; Wickenberg, W; Wicklund, A B; Wicklund, E; Wigmans, R; Wike, C; Wilkes, T; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Wong, M; Worcester, M; Worland, R; Worm, S; Wright, T; Wu, J; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yarema, R J; Yeh, G P; Yi, K; Yocum, D R; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zalokar, M; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zimmerman, T; Zsenei, A; Zucchelli, S

    2003-01-01

    We present a measurement of the mass difference m(D+_s) - m(D+), where both the D+_s and D+ are reconstructed in the phi pi+ decay channel. This measurement uses 11.6 pb-1 of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be: 99.41 +- 0.38 (stat) +- 0.21 (syst) MeV/c^2.

  1. Dr René Favaloro (1923-2000) Rene Favaloro MD (1923-2000)

    OpenAIRE

    Sergio Morán V

    2000-01-01

    René Favaloro MD, was born in La Plata, Argentina, in July 1923. He studied medicine in La Plata and made his cardiology residence in the Cleveland Clinic, where he developed coronary bypass surgery for the treatment of ischemic heart disease. At the present time, this surgical procedure is a well recognized therapy for coronary artery disease that has benefited millions of patients. Back in Argentina, he founded in 1992 the Institute of Cardiology and Cardiovascular Surgery that had an impor...

  2. Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX) for Bionanosystem Simulations

    OpenAIRE

    Miao, Yinglong; Ortoleva, Peter J.

    2009-01-01

    A multiscale approach, Molecular Dynamics/Order Parameter eXtrapolation (MD/OPX), to the all-atom simulation of large bionanosystems is presented. The approach starts with the introduction of a set of order parameters (OPs) automatically generated with orthogonal polynomials to characterize the nanoscale features of bionanosystems. The OPs are shown to evolve slowly via Newton’s equations and the all-atom multiscale analysis (AMA) developed earlier1 demonstrates the existence of their stochas...

  3. Why is mu/md so much smaller than mc/ms and mt/mb?

    International Nuclear Information System (INIS)

    We propose that the smallness of mu/md is due to the ''wrong'' Yukawa coupling of the up quark in a two-Higgs-doublet model. The model has natural flavor conservation only among charges -1/3 quarks and leptons. We estimate that D0-bar D 0 mixing is much larger than the value of the standard-model box diagrams, and could be larger than or comparable to the long-distance contributions,

  4. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  5. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Agrawal

    2013-09-01

    Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

  6. Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment

    Science.gov (United States)

    Wernham, Madelaine; Jarrett, Pamela G.; Stewart, Connie; MacDonald, Elizabeth; MacNeil, Donna; Hobbs, Cynthia

    2014-01-01

    Background The assessment of fitness to drive in patients with cognitive impairment is complex. The SIMARD MD was developed to assist with assessing fitness to drive. This study compares the clinical decision made by a geriatrician regarding driving with the SIMARD MD score. Methods Patients with a diagnosis of mild dementia or mild cognitive impairment, who had a SIMARD MD test, were included in the sample. A retrospective chart review was completed to gather diagnosis, driving status, and cognitive and functional information. Results Sixty-three patients were identified and 57 met the inclusion criteria. The mean age was 77.1 years (SD 8.9). The most common diagnosis was Alzheimer’s disease in 22 (38.6%) patients. The mean MMSE score was 24.9 (SD 3.34) and the mean MoCA was 19.9 (SD 3.58). The mean SIMARD MD score was 37.2 (SD 19.54). Twenty-four patients had a SIMARD MD score ≤ 30, twenty-eight between 31–70, and five scored > 70. The SIMARD MD scores did not differ significantly compared to the clinical decision (ANOVA p value = 0.14). Conclusions There was no association between the SIMARD MD scores and the geriatricians’ clinical decision regarding fitness to drive in persons with mild dementia or mild cognitive impairment. PMID:24883164

  7. Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

    Directory of Open Access Journals (Sweden)

    Aruna Rajan

    Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

  8. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Gyeonggeun; Kil, Soyeon; Kwon, Junhyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs.

  9. MD-portal Materials Database: Effective Materials Property Information Management in Nuclear Energy Systems

    International Nuclear Information System (INIS)

    The collective properties of the nuclear materials are defined as standard industrial codes such as ASME codes. While in service, the materials are aged and degraded, and the initial properties are changed according to the operating environments. These changes are a matter of substantial concern of the operators, regulators, and researchers in nuclear fields. Hence, the material property database considering the degradation is required, and the successful management and use of material property information must be responsive to the continuing changes and increasing complexity in nuclear engineering materials. Recently, the nuclear materials division in the Korea Atomic Energy Research Institute (KAERI) launched a comprehensive portal website for nuclear material information, which is known as the MD-portal. The MD-portal contains various technical documents on the degradation and development of nuclear materials. Additionally, the nuclear materials database (MatDB) is incorporated in it. The MatDB covers the mechanical properties of various nuclear structural materials used as the components: a reactor pressure vessel, steam generator, and primary and secondary piping. In this study, we introduced the MD-portal MatDB briefly, and showed an application of the MatDB to the real case of material degradations in NPPs

  10. The Algorithm Design for Preventing URL Modified Based on MD5%基于MD5的URL防篡改算法设计

    Institute of Scientific and Technical Information of China (English)

    刘国卿

    2011-01-01

    针对常用的URL篡改攻击,提出了一种基于MD5加密的URL防篡改算法。该算法将一段哈希代码作为校验码附加到目标URL后,在页面逻辑运行完成前采用过滤器实现校验码的比对,从而完成URL是否被篡改的判断;最后,基于.NET平台实现了新链接生成模块和校验模块,并讨论了模块的部署。%For preventing URL modified, this paper proposed a algorithm design, which could be used to cheek out the modification of URL efficiently. The algorithm adds a hashed MAC to order URL,it makes it posible to learn whether the URL he modified. Furthermore,

  11. 基于MD5加密的Tornado码复制算法改进%An improved algorithm based on MD5 encryption Tornado code

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.%基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。

  12. An improved algorithm based on MD5 encryption Tornado code%基于MD5加密的Tornado码复制算法改进

    Institute of Scientific and Technical Information of China (English)

    骆正平; 陈中育; 林郁峰; 吴星同

    2015-01-01

    基于Tornado码的复制算法具有编解码速度比较快、部分数据丢失时亦能被恢复的优点,但将该算法应用于分布式存储系统时,存在数据易被窃取、篡改的风险。为此,对基于Tornado码的复制算法提出了改进:1)引入加密机制,使数据即使被窃取时也不用担心泄密;2)对原始数据使用MD5算法产生数字指纹,当从分布式存储系统取回数据时,计算数字指纹并与本地的数字指纹对比,就可以判断数据是否被篡改。%Tornado code based replication algorithm had the advantages of faster encoding and decoding, and could also recover the original data when some data were missing, but when the algorithm was applied to a dis-tributed storage system, the presence of data would be susceptible to theft, tampering risk. For this reason, several optimization strategies were proposed to improve the replication algorithm based on Tornado code:1 ) an encryption mechanism into replication algorithm was introduced in case of even some data were stolen there would be no worry about information leak. 2)the raw data using the MD5 algorithm to generate digital finger-prints produced a digital fingerprint when retrieving data from a distributed storage system with local digital fin-gerprint comparison, it would be easy to determine whether the data had been tampered with.

  13. The application of MD5 algorithm in telephone speech system software protection%MD5算法在电话语音系统软件保护中的应用

    Institute of Scientific and Technical Information of China (English)

    段青玲; 杨仁刚; 李辉

    2007-01-01

    本文首先对软件保护技术进行了简要的概述,在剖析MD5算法工作原理的基础上,提出了基于MD5加密算法的软件硬加密保护方案.该方案根据机器的CPU序列号和语音卡号使用MD5加密算法自动生成软件序列号,并对MD5加密算法的输入输出数据进行变化处理.结果显示,该方法实现了"一机一码",并已应用于某"电话语音系统"中.

  14. MD5报文摘要算法与文件系统完整性保护%MD5 Message Digest Algorithm and Protection of File System Integrity

    Institute of Scientific and Technical Information of China (English)

    李杰; 张学旺

    2003-01-01

    MD5报文摘要算法是一种应用广泛的提取数字指纹的算法.文件系统完成性保护利用MD5算法产生文件或对象的数字指纹以识别它们的微小变化而实施保护.本文详细剖析了MD5算法的工作原理,以及基于MD5算法的文件系统完整性检查程序的原理、设计和实现.

  15. A Greedy Algorithm to solve md-MST Problem Based on Edgeexchange%一种基于边交换的贪心算法求解md-MST问题

    Institute of Scientific and Technical Information of China (English)

    赵磊; 刘辉; 魏书堤; 陈坚祯; 林睦纲

    2015-01-01

    通过对最小度限制最小生成树(md-MST)问题性质进行分析,提出了一种基于边交换的贪心算法.算法先用贪心算法生成一棵生成树ST,然后对生成树ST经过边交换调整,得到满足问题约束条件的可行解,再对生成树ST进行进一步边交换优化,得到md-MST问题的最优解或接近最优解的近似解.实验证明,算法能在短时间内求出大规模顶点随机图的md-MST,是一种非常实用的求解md-MST问题的精确算法.

  16. A Method that Preventing URL Attack Based on MD5 Encryption Algorithm%一种采用MD5加密算法防止URL攻击的方法

    Institute of Scientific and Technical Information of China (English)

    张杰; 李华伟; 周立军

    2011-01-01

    在简要分析当前URL攻击手段的基础上,提出一种使用MD5加密算法有效防止URL攻击的方法,按照URL合法性检测流程,设计基于Java MVC轻量级框架Struts的测试方案,比较MD5和DES算法在URL参数加密过程中的性能.

  17. Application of MD5 Encryption Algorithm in Registration and Login Verification Module%MD5加密算法在注册及登录验证模块中的应用

    Institute of Scientific and Technical Information of China (English)

    周小红; 周建伙

    2015-01-01

    With the development of Internet technology,information security is becoming more and more popular.This pa-per introduces the basic principle of the MD5 encryption algorithm.The application of MD5 encryption algorithm in the regis-tration and login verification module in the.NET environment through Visual C# is introduced in detail.The security of MD5 al-gorithm is analyzed.Final y,put forward and realize the improvement method.%随着互联网技术的发展,信息安全越来越受到人们的关注。介绍了MD5加密算法的基本原理,详细介绍如何在。 NET环境下通过Visual C#实现MD5加密算法在注册及登录验证模块中的应用。分析MD5算法的安全性,最后提出并实现自己的改进方法。

  18. MD5加密算法改进及其特征码在杀毒软件中的应用%An improved MD5 encryption algorithm and application in anti-virus software

    Institute of Scientific and Technical Information of China (English)

    贾晓强

    2015-01-01

    文章分析了MD5算法发展、危机、碰撞分析并加入"盐值"对算法做了改进,然后给出了其C++的具体实现算法;分析MD5特征码的特点构建了特征库配置文件,用VC实现了基于特征码的杀毒软件,此软件能根据文件特征码(MD5值)成功删除可疑文件。%The paper analyzed the development, crisis and the collision of the MD5 algorithm,by adding the"salt value", the algorithm has been improved. And then gived the concrete implementation of the algorithm with c++language;Analysis of the characteristics of the MD5 signature feature ,database configuration file is constructed, using VC implementation anti-virus software based on signature feature, the software can according to the file signature (MD5 value) successfully delete suspicious files.

  19. 浅谈六种加密算法之三——MD5算法

    Institute of Scientific and Technical Information of China (English)

    周庆

    2005-01-01

    MD5的全称是“nessage-digest algorithm 5”(信息-摘要算法),它是90年代初由MIT计算机科学实验室和RSA Data Security Inc联合开发,并经过MD2、MD3和MD4逐渐演变而来的。其主要作用是让大容量信息在用数字签名软件签署私人“密匙”前被“压缩”成一种保密的格式(就是把一个任意长度的字符串转变成一定长度的大整数),

  20. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Science.gov (United States)

    2010-07-01

    ... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point Wharf... located at Reedy Point and Old Town Point Wharf. These traffic lights are described in the rules...

  1. Seismicity patterns before MD >= 4.1 earthquakes in the Friuli-Venezia Giulia (northeastern Italy) and western Slovenia areas

    OpenAIRE

    Gentili, Stefania; Bressan, Gianni

    2007-01-01

    International audience The spatial-temporal pattern of seismicity, preceding 5 moderate-sized earthquakes with MD ≥ 4.1, that occurred in the Friuli-Venezia Giulia region (northeastern Italy) and in western Slovenia, is investigated with the Region-Time-Length (RTL) and the PI algorithms. These algorithms were originally formulated to reveal the variation of seismicity patterns before large earthquakes. The RTL algorithm detects seismic quiescences before the 1996 Claut earthquake (MD 4.3)...

  2. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    OpenAIRE

    Jagdish Prasad Agrawal; Mandira Shahi

    2013-01-01

    Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6) MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC) of Institute of Medicine, Maharajgu...

  3. Message Digest Algorithm 5 Apply in PHP+MYSQL%MD5算法在PHP+MYSQL中的应用

    Institute of Scientific and Technical Information of China (English)

    苟玮; 姚旺生; 郭福亮

    2007-01-01

    在以web形式提供服务的系统中,用户从浏览器登录服务器数据库时,信息的安全性至关重要.主要讨论MD5算法在PHP+MYSQL中的应用,分析MD5算法的不足并提出了解决方法.

  4. House M.D.: the monitoring of life, crime and disease in the age of its technical visuality

    OpenAIRE

    Ivana Bentes

    2011-01-01

    When the body, the subjectivity and disease are converted into medical information, statistics and ballistics, MRI, contrasts, maps and images, they appear as new actors and dramatic elements in contemporary fiction, especially in series as House M.D. and CSI. In this article, we analyze some House M.D. episodes, highlighting how these body visualization technologies, genetic mapping, diagnostics, monitoring procedures, equipment for production of evidences of every kind (medical and criminal...

  5. The MD Design - a cool concept for geologic disposal of radioactive waste

    International Nuclear Information System (INIS)

    The scheduled disposal capacity for spent nuclear fuel and other high-level radioactive wastes (HLW) is inadequate and the estimated supply of recoverable uranium for continued nuclear energy production is scarce in the beginning of the 21st century. Hence, the development of a safe method for permanent disposal of HLW is an imminent global imperative to the continued development and use of nuclear energy, as is the prudent use of available uranium resources. However, permanent disposal of HLW poses a potential long-term public health and environmental hazard (risk) presenting unprecedented scientific challenges as well as moral, ethical and political concerns. The Minimum Disturbance to the Geologic Setting (MD) Design is an integrated, generic, low-temperature (cool), cradle-to-grave, radioactive waste management system for safe geologic disposal of radioactive waste. The application of the MD Design introduced in this paper is a safe and cost-effective geologic repository for permanent disposal of HLW. The main safety features are: Highly focused site selection and site characterization; mechanical mining; maximum near-field geologic setting temperature of 90 degrees Centigrade (degrees C) (194 degrees Fahrenheit [degrees F]); long-term primary (substantial) radionuclide containment by the engineered barriers system (EBS); long-term near-field monitoring; and a three-tiered licensing process. The main cost-effective features are: Concurrent construction and operation; remote controlled handling and in-room emplacement of HLW; and ready long-term access to the emplaced HLW. The unique combination of new and old safety and HLW disposal concepts in the MD Design offers potential solutions to three global HLW disposal problems; credible validation of safety assessments; enhanced HLW disposal capacity; and ready long-term access to a reusable, scarce natural energy resource - uranium

  6. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students. PMID:27499363

  7. Constant-pH MD Simulations of an Oleic Acid Bilayer.

    Science.gov (United States)

    Vila-Viçosa, Diogo; Teixeira, Vitor H; Baptista, António M; Machuqueiro, Miguel

    2015-05-12

    Oleic acid is a simple molecule with an aliphatic chain and a carboxylic group whose ionization and, consequently, intermolecular interactions are strongly dependent on the solution pH. The titration curve of these molecules was already obtained using different experimental methods, which have shown the lipid bilayer assemblies to be stable between pH 7.0 and 9.0. In this work, we take advantage of our recent implementations of periodic boundary conditions in Poisson-Boltzmann calculations and ionic strength treatment in simulations of charged lipid bilayers, and we studied the ionization dependent behavior of an oleic acid bilayer using a new extension of the stochastic titration constant-pH MD method. With this new approach, we obtained titration curves that are in good agreement with the experimental data. Also, we were able to estimate the slope of the titration curve from charge fluctuations, which is an important test of thermodynamic consistency for the sampling in a constant-pH MD method. The simulations were performed for ionizations up to 50%, because an experimentally observed macroscopic transition to micelles occurs above this value. As previously seen for a binary mixture of a zwitterionic and an anionic lipid, we were able to reproduce experimental results with simulation boxes usually far from neutrality. This observation further supports the idea that a charged membrane strongly influences the ion distribution in its vicinity and that neutrality is achieved significantly far from the bilayer surface. The good results obtained with this extension of the stochastic titration constant-pH MD method strongly supports its usefulness to sample the coupling between configuration and protonation in these types of biophysical systems. This method stands now as a powerful tool to study more realistic lipid bilayers where pH can influence both the lipids and the solutes interacting with them. PMID:26574431

  8. The scope and variety of combined baccalaureate-MD programs in the United States.

    Science.gov (United States)

    Eaglen, Robert H; Arnold, Louise; Girotti, Jorge A; Cosgrove, Ellen M; Green, Marianne M; Kollisch, Donald O; McBeth, Dani L; Penn, Mark A; Tracy, Sarah W

    2012-11-01

    The landscape of combined baccalaureate-MD programs has changed substantially in the last two decades but has not been documented in detail. The authors review the current state of these programs and discuss opportunities for future study of their evolving role and potential impact.In 2011, using a definition of baccalaureate-MD program built on prior research, the authors reviewed Association of American Medical Colleges sources and medical school Web sites to identify and characterize 81 active programs. In addition, they surveyed the 57 medical schools offering those programs; 31 schools with 39 programs responded. The resulting database inventories the number and distribution of programs; institutional affiliations; missions or goals; length; size; admissions criteria; curricula; and retention requirements.Since the inception of combined programs in 1961, their number and curricular length have increased. Pressures that spurred earlier programs remain evident in the goals of today's programs: attract talented high school or early college students, especially from diverse backgrounds; prepare physicians to meet societal needs; and offer an enriched premedical environment. Baccalaureate educational activities achieve program goals through special courses, medical experiences, community service, and learning communities tailored to students' needs. Admission and retention criteria are comparable to those of traditional medical schools.Combined baccalaureate-MD programs have evolved along several paths during the last half century and have enriched the baccalaureate experiences of medical students. Shifting expectations for the selection and education of future physicians warrant focused research on these programs to document their effectiveness in addressing those expectations. PMID:23018320

  9. Understanding the mechanism of LCST phase separation of mixed ionic liquids in water by MD simulations.

    Science.gov (United States)

    Zhao, Yuling; Wang, Huiyong; Pei, Yuanchao; Liu, Zhiping; Wang, Jianji

    2016-08-17

    Recently, it has been found experimentally that two different amino acid ionic liquids (ILs) can be mixed to show unique lowest critical solution temperature (LCST) phase separation in water. However, little is known about the mechanism of phase separation in these IL/water mixtures at the molecular level. In this work, five kinds of amino acid ILs were chosen to study the mechanism of LCST-type phase separation by molecular dynamics (MD) simulations. Toward this end, a series of all-atom MD simulations were carried out on the ternary mixtures consisting of two different ILs and water at different temperatures. The various interaction energies and radial distribution functions (RDFs) were calculated and analyzed for these mixed systems. It was found that for amino acid ILs, the -NH2 or -COOH group of one anion could have a hydrogen bonding interaction with the -COO(-) group of another anion. With the increase of temperature, this kind of hydrogen bonding interaction between anions was strengthened and then the anion-H2O electrostatic interaction was weakened, which led to the LCST-type phase separation of the mixed ILs in water. In addition, a series of MD simulations for [P6668]1[Lys]n[Asp]1-n/H2O systems were also performed to study the effect of the mixing ratio of ILs on phase separation. It was also noted that the experimental critical composition corresponding to the lowest critical solution temperature was well predicted from the total electrostatic interaction energies as a function of mole fraction of [P6668][Lys] in these systems. The conclusions drawn from this study may provide new insight into the LCST-type phase behavior of ILs in water, and motivate further studies on practical applications. PMID:27498928

  10. Direct MD simulation of liquid-solid phase equilibria for two-component plasmas

    OpenAIRE

    Schneider, A. S.; Hughto, J.; Horowitz, C. J.; Berry, D. K.

    2011-01-01

    We determine the liquid-solid phase diagram for carbon-oxygen and oxygen-selenium plasma mixtures using two-phase MD simulations. We identified liquid, solid, and interface regions using a bond angle metric. To study finite size effects, we perform 27648 and 55296 ion simulations. To help monitor non-equilibrium effects, we calculate diffusion constants $D_i$. For the carbon-oxygen system we find that $D_O$ for oxygen ions in the solid is much smaller than $D_C$ for carbon ions and that both ...

  11. Rekonstrukcija i izrada 3D modela dvo-osne konvencionalne tokarilice Hobbymat MD65

    OpenAIRE

    Hršak, Božidar; Pavlic, Tomislav; Radić, Antonio

    2014-01-01

    Prikazan je postupak rekonstrukcije konvencionalne tokarilice Hobbymat MD65 u CNC (Computer Numerical Control) stroj s dvije simultane osi ugradnjom koračnih motora tipa NEMA 23 i upravljanih PC programskim sustavom Mach3-Lathe. 3D model je izrađen u programskom alatu Solid Edge ST4 – Ordered Technology, a fotorealistički prikaz modela u programskom modulu ERA (ExplodeRenderAnimate). Na temelju dokumentacije o montaži i održavanju i mjernih skica izrađena je kompletna 2D tehnička dokumentacij...

  12. Neutron emission as a function of fragment energy in the spontaneous fission of 260Md

    International Nuclear Information System (INIS)

    The authors have made the first measurement of the number of neutrons emitted in the spontaneous fission of a nuclide in which very high fragment energies dominate the fission process. In bombardments of 254Es, they produced 28-d 260Md, which was neutron-counted in a 1-m-diam spherical tank containing a Gd-doped scintillator solution. The average number of neutrons emitted per fission is only 2.58 ± 0.11, substantially less than for other actinides. A direct correlation of neutron multiplicity with fragment excitation energy is clearly demonstrated

  13. SN 2009md: Another faint supernova from a low mass progenitor

    OpenAIRE

    Fraser, M; Ergon, M.; Eldridge, J. J.; Valenti, S.; Pastorello, A.; Sollerman, J; Smartt, S. J.; Agnoletto, I.; Arcavi, I.; Benetti, S.; Botticella, M. -T.; Bufano, F.; Campillay, A.; Crockett, R. M.; Gal-Yam, A.

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival \\emph{Hubble Space Telescope} data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/L$_{\\odot}$ $\\sim4.54\\pm0.19$ dex. Using the stellar evolution code STARS, we find this to be consistent with a ...

  14. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    OpenAIRE

    R.V. Oliveira; P.C.C. Campos; P.A.S. Mourão

    2011-01-01

    In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil...

  15. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    OpenAIRE

    R.V. Oliveira; P.C.C. Campos; P.A.S. Mourão

    2011-01-01

    In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A no...

  16. Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

    Science.gov (United States)

    Dhindsa, Gurpreet K.

    Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

  17. A workshop on leadership for senior MD-PhD students

    OpenAIRE

    Meador, Catherine B.; Parang, Bobak; Musser, Melissa A.; Haliyur, Rachana; Owens, David A.; Terence S Dermody

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD–PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a hi...

  18. A Conversation with David Bates, MD, MSc, Chairman of the American Medical Informatics Association

    OpenAIRE

    Raymond, Brian

    2008-01-01

    A world-renowned physician-researcher, David Bates, MD, MSc, is Chief of the Division of General Medicine at the Brigham and Women's Hospital in Boston, MA, and a Professor at Harvard Medical School and the Harvard School of Public Health, where he is codirector of the Program in Clinical Effectiveness. He is the Medical Director of Clinical and Quality Analysis, Information Systems at Partners HealthCare System, Inc. He is also the former Chair of the National Alliance for Primary Care Infor...

  19. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Shanshuang, E-mail: shiss@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Song, Yuntao; Yang, Qingxi; Xu, Hao; Wang, Zhongwei [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Liu, Wandong; Li, Hong; Wan, Shude; Ding, Weixing [School of Physical Sciences, University of Science and Technology of China, Hefei 230031 (China); Luo, Zhiren; Zheng, Jinxing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2013-12-15

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C.

  20. Numerical analysis of MD events and preliminary thermal calculation for KTX vacuum vessel

    International Nuclear Information System (INIS)

    Highlights: • To verify design strength, EM and mechanical analysis was implemented. • During MD events, the radial force due to large eddy current is predominant. • We confirmed the VV structure is still strong enough even in the most severe condition. • Preliminary thermal calculation suggested suitable discharge parameters. -- Abstract: KTX is a new reversed field pinch (RFP) magnetic confinement device which is under design in ASIPP and USTC. Major disruption (MD) events may occur in future operating process, which is simulated with the finite element (FE) method. The results present that the peaks of eddy currents on vessel and conductor shell are respectively 11.791 kA and 68.637 kA with maximum stress 67.1 MPa due to high transient electromagnetic (EM) force. It is confirmed that the structure is still strong enough to bear the electromagnetic loads even if the worst case. Besides, as KTX vacuum vessel will take the method of natural cooling for heat dissipation during plasma discharge (0.5–1.0 MA), a preliminary thermal calculation was implemented in normal condition to decide suitable time parameters such as duration and interval. It is suggested that the discharge interval should be no less than 5 min for the complete 1 MA plasma with 100 ms duration, which can guarantee the temperature of vacuum vessel below 200 °C

  1. Portuguese validation of the Symptom Inventory of the M.D. Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Adriane Cristina Bernat Kolankiewicz

    2014-12-01

    Full Text Available Objective To analyze the reliability and validity of the psychometric properties of the Brazilian version of the instrument for symptom assessment, titled MD Anderson Symptom Inventory - core. Method A cross-sectional study with 268 cancer patients in outpatient treatment, in the municipality of Ijuí, state of Rio Grande do Sul, Brazil. Results The Cronbach’s alpha for the MDASI general, symptoms and interferences was respectively (0.857, (0.784 and (0.794. The factor analysis showed adequacy of the data (0.792. In total, were identified four factors of the principal components related to the symptoms. Factor I: sleep problems, distress (upset, difficulties in remembering things and sadness. Factor II: dizziness, nausea, lack of appetite and vomiting. Factor III: drowsiness, dry mouth, numbness and tingling. Factor IV: pain, fatigue and shortness of breath. A single factor was revealed in the component of interferences with life (0.780, with prevalence of activity in general (59.7%, work (54.9% and walking (49.3%. Conclusion The Brazilian version of the MD Anderson Symptom Inventory - core showed adequate psychometric properties in the studied population.

  2. Full-Scale Crash Test of a MD-500 Helicopter with Deployable Energy Absorbers

    Science.gov (United States)

    Kellas, Sotiris; Jackson, Karen E.; Littell, Justin D.

    2010-01-01

    A new externally deployable energy absorbing system was demonstrated during a full-scale crash test of an MD-500 helicopter. The deployable system is a honeycomb structure and utilizes composite materials in its construction. A set of two Deployable Energy Absorbers (DEAs) were fitted on the MD-500 helicopter for the full-scale crash demonstration. Four anthropomorphic dummy occupants were also used to assess human survivability. A demonstration test was performed at NASA Langley's Landing and Impact Research Facility (LandIR). The test involved impacting the helicopter on a concrete surface with combined forward and vertical velocity components of 40-ft/s and 26-ft/s, respectively. The objectives of the test were to evaluate the performance of the DEA concept under realistic crash conditions and to generate test data for validation of dynamic finite element simulations. Descriptions of this test as well as other component and full-scale tests leading to the helicopter test are discussed. Acceleration data from the anthropomorphic dummies showed that dynamic loads were successfully attenuated to within non-injurious levels. Moreover, the airframe itself survived the relatively severe impact and was retested to provide baseline data for comparison for cases with and without DEAs.

  3. SN 2009md: Another faint supernova from a low mass progenitor

    CERN Document Server

    Fraser, M; Eldridge, J J; Valenti, S; Pastorello, A; Sollerman, J; Smartt, S J; Agnoletto, I; Arcavi, I; Benetti, S; Botticella, M -T; Bufano, F; Campillay, A; Crockett, R M; Gal-Yam, A; Kankare, E; Leloudas, G; Maguire, K; Mattila, S; Maund, J R; Salgado, F; Stephens, A; Taubenberger, S; Turatto, M

    2010-01-01

    We present adaptive optics imaging of the core collapse supernova (SN) 2009md, which we use together with archival HST data to identify a coincident progenitor candidate. We find the progenitor to have an absolute magnitude of $V = -4.63^{+0.3}_{-0.4}$ mag and a colour of $V-I = 2.29^{+0.25}_{-0.39}$ mag, corresponding to a progenitor luminosity of log $L$/\\lsun $\\sim4.3\\pm0.2$ dex. Using the stellar evolution code STARS, we find this to be consistent with a red supergiant progenitor with $M = 7_{-1}^{+5}$ \\msun. The photometric and spectroscopic evolution of SN 2009md is similar to that of the class of sub-luminous Type IIP SNe. We estimate the mass of $^{56}$Ni ejected in the explosion to be $(5.4\\pm1.3) \\times 10^{-3}$ \\msun\\ from the luminosity on the radioactive tail, which is in agreement with the low $^{56}$Ni masses estimated for other sub-luminous Type IIP SNe. Simple modeling of the SN is presented, where we include a constraint on the radius from progenitor observations. Using this modeling we find...

  4. Numerical simulations of magnetic materials with MD-GRAPE: curvature induced anisotropy

    International Nuclear Information System (INIS)

    The time development of an array of magnetic dipoles representing the internal magnetization of a thin film is calculated using a hardware accelerator, MD-GRAPE, for the determination of the magnetic vector potential. The results for single-layer arrays of dipoles are compared with the analogous results obtained from an FFT method and found to be in reasonable agreement. Three-dimensional MD-GRAPE simulations with sinusoidal deformations illustrate the utility of the hardware accelerator in cases that cannot be solved easily with FFT methods. The deformations give the internal field an asymmetry with components parallel to the wave crest, leading to significant changes in the critical external fields required for switching. These changes occur even for small wave amplitudes, comparable to or less than the layer thickness. Layer curvature affects the astroid pattern of critical field strengths by shifting the threshold to lower absolute values of the hard axis field when the curvature is in the easy axis direction, and lower absolute values of the easy axis field when the curvature is in the hard axis direction. This effect of curvature differs from orange peel coupling between two layers because here there is only one layer, and because orange peel coupling shifts the whole astroid pattern as a result of an effective field bias, whereas here the pattern shape is changed without any centroid shift

  5. Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques

    Directory of Open Access Journals (Sweden)

    Carla Isernia

    2013-09-01

    Full Text Available Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such regions, including the description of their structural propensities, number of conformations and relative populations can provide useful insights. Prion diseases result from the conversion of a normal glycoprotein into a misfolded pathogenic isoform. The structures of mammal and chicken prion proteins show a similar fold with a globular domain and a flexible N-terminal portion that contains different repeated regions: octarepeats (PHGGGWGQ in mammals and hexarepeats (PHNPGY in chickens. The higher number of prolines in the hexarepeat region suggests that this region may retain a significant amount of residual secondary structure. Here, we report the CD, NMR and MD characterization of a peptide (2-HexaPY composed of two hexarepeats. We combine experimental NMR data and MD to investigate at atomic level its ensemble-averaged structural properties, demonstrating how each residue of both repeats has a different quantified PPII propensity that shows a periodicity along the sequence. This feature explains the absence of cooperativity to stabilize a PPII conformation. Nonetheless, such residual structure can play a role in nucleating local structural transitions as well as modulating intra-molecular or inter-molecular interactions.

  6. The embedded atom model and large-scale MD simulation of tin under shock loading

    International Nuclear Information System (INIS)

    The goal of the work was to develop an interatomic potential, that can be used in large-scale classical MD simulations to predict tin properties near the melting curve, the melting curve itself, and the kinetics of melting and solidification when shock and ramp loading. According to phase diagram, shocked tin melts from bcc phase, and since the main objective was to investigate melting, the EAM was parameterized for bcc phase. The EAM was optimized using isothermal compression data (experimental at T=300 K and ab-initio at T=0 K for bcc, fcc, bct structures), experimental and QMD data on the Hugoniot and on the melting at elevated pressures. The Hugoniostat calculations centred at β-tin at ambient conditions showed that the calculated Hugoniot is in good agreement with experimental and QMD data above p-bct transition pressure. Calculations of overcooled liquid in pressure range corresponding to bcc phase showed crystallization into bcc phase. Since the principal Hugoniot of tin originates from the β-tin that is not described by this EAM the special initial state of bcc samples was constructed to perform large-scale MD simulations of shock loading.

  7. Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

    Science.gov (United States)

    Zhen, Yunmei; Qin, Guangrong; Luo, Cheng; Jiang, Hualiang; Yu, Kunqian; Chen, Guanghui

    2014-01-01

    Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3) mediates Ubiquitin (Ub) modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2) linked to Ub via a thioester bond to form a catalytic complex. The mechanism of Ub transfer catalyzed by RING E3 remains elusive. By employing a combined computational approach including molecular modeling, molecular dynamics (MD) simulations, and quantum mechanics/molecular mechanics (QM/MM) calculations, we characterized this catalytic mechanism in detail. The three-dimensional model of dimeric RING E3 ligase RNF4 RING, E2 ligase UbcH5A, Ub and the substrate SUMO2 shows close contact between the substrate and Ub transfer catalytic center. Deprotonation of the substrate lysine by D117 on UbcH5A occurs with almost no energy barrier as calculated by MD and QM/MM calculations. Then, the side chain of the activated lysine gets close to the thioester bond via a conformation change. The Ub transfer pathway begins with a nucleophilic addition that forms an oxyanion intermediate of a 4.23 kcal/mol energy barrier followed by nucleophilic elimination, resulting in a Ub modified substrate by a 5.65 kcal/mol energy barrier. These results provide insight into the mechanism of RING-catalyzed Ub transfer guiding the discovery of Ub system inhibitors. PMID:25003393

  8. Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

    Directory of Open Access Journals (Sweden)

    Yunmei Zhen

    Full Text Available Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3 mediates Ubiquitin (Ub modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2 linked to Ub via a thioester bond to form a catalytic complex. The mechanism of Ub transfer catalyzed by RING E3 remains elusive. By employing a combined computational approach including molecular modeling, molecular dynamics (MD simulations, and quantum mechanics/molecular mechanics (QM/MM calculations, we characterized this catalytic mechanism in detail. The three-dimensional model of dimeric RING E3 ligase RNF4 RING, E2 ligase UbcH5A, Ub and the substrate SUMO2 shows close contact between the substrate and Ub transfer catalytic center. Deprotonation of the substrate lysine by D117 on UbcH5A occurs with almost no energy barrier as calculated by MD and QM/MM calculations. Then, the side chain of the activated lysine gets close to the thioester bond via a conformation change. The Ub transfer pathway begins with a nucleophilic addition that forms an oxyanion intermediate of a 4.23 kcal/mol energy barrier followed by nucleophilic elimination, resulting in a Ub modified substrate by a 5.65 kcal/mol energy barrier. These results provide insight into the mechanism of RING-catalyzed Ub transfer guiding the discovery of Ub system inhibitors.

  9. An MD-PhD program in Brazil: students’ concepts of science and of common sense

    Directory of Open Access Journals (Sweden)

    R.V. Oliveira

    2011-11-01

    Full Text Available In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A noteworthy absence of interest in carrying out clinical research limits the ability of young Brazilian physicians to solve biomedical problems. To understand the students’ views of science, we used qualitative and quantitative triangulation methods, as well as participant observation to evaluate the students’ concepts of science and common sense. Subjective aspects were clearly less evident in their concepts of science. There was a strong concern about "methodology", "truth" and "usefulness". "Intuition", "creativity" and "curiosity" were the least mentioned thematic categories. Students recognized the value of intuition when it appeared as an explicit option but they did not refer to it spontaneously. Common sense was associated with "consensus", "opinion" and ideas that "require scientific validation". Such observations indicate that MD-PhD students share with their senior academic colleagues the same reluctance to consider common sense as a valid adjunct for the solution of scientific problems. Overcoming this difficulty may be an important step toward stimulating the interest of physicians in pursuing experimental research.

  10. 基于JAVA技术的MD5加密算法的设计与实现%Design and Implementation of MD5 Algorithm Based on JAVA Technology

    Institute of Scientific and Technical Information of China (English)

    张浩华; 齐维毅; 赵子夫; 李瑶; 潘庆超

    2009-01-01

    详细描述了在数字签名、电子商务、信息加密领域中广泛应用的MD5加密算法,并针对其高效、跨平台使用,提出利用JSP与JavaBean相结合的技术方法实现MD5加密算法.该方法采用Java语言实现MD5算法,并利用JavaBean组件进行封装,通过JSP技术进行相应页面的动态展现,既简化JSP网页结构体现了Java体系的技术优势,又保证了应用系统的安全性、跨平台性和提高系统的执行效率.

  11. 一种基于MD5的近似图像检测算法研究%Research of similar images detection algorithm based on MD5

    Institute of Scientific and Technical Information of China (English)

    叶志伟; 夏彬; 王大震; 张彦超

    2010-01-01

    在WWW图像搜索引擎中,如何快速而准确地检测出近似或重复图像已经成为亟待解决的问题,提出一种基于MD5的近似图像检测算法.该算法选取图像分块灰度均值为特征,经过拉普拉斯特征值降维,矢量量化后,图像特征被转换为MD5值,然后根据生成的MD5值进行近似或重复图像检测.实验结果表明该算法是有效的.

  12. 基于NetMagic平台的MD5算法硬件加速模型%Hardware acceleration model of MD5 algorithm based on NetMagic platform

    Institute of Scientific and Technical Information of China (English)

    孟祥扬; 林琦

    2015-01-01

    针对MD5软件实现方法存在占用资源大、安全性差等缺点,提出了基于NetMagic平台的MD5硬件加速模型设计方案,并基于ModelSim和NetMagic平台对提出的非流水线与流水线硬件加速模型进行验证、分析.相比非流水线硬件加速模型,流水线硬件加速模型能提高MD5运算效率5倍,可用于网络处理器等硬件加密引擎,有效提高网络处理器等硬件设备的安全性和处理效率.

  13. Encrypt the User Password with the MD5 Algorithm in JAVA WEB System%JAVA WEB系统用MD5算法加密用户口令

    Institute of Scientific and Technical Information of China (English)

    李茂春; 王和顺

    2010-01-01

    在网络传输中,我们要确保一些敏感的数据在传输的过程中不会被篡改、截取,这就需要用加密算法对传输的信息进行加密.MD5是一种单向加密算法,其加密后的数据难以解密,所以广泛应用在各大型网站以及管理系统中用来保护用户口令安全.文章介绍了MD5加密算法的工作原理,并以实际应用为例介绍了JAVA WEB应用中的MD5加密算法.

  14. 基于MD5算法的身份鉴别技术的研究与实现%Study and Realization of Authentication Technique Based on MD5 Algorithm

    Institute of Scientific and Technical Information of China (English)

    张建伟; 李鑫; 张梅峰

    2003-01-01

    MD5报文摘要算法是一种应用广泛的身份认证算法,该文首先对数据加密技术进行了简要的概述.在剖析MD5算法工作原理的基础上,结合DES加密算法,采用加入时间戳、绑定IP地址的基于MD5文摘算法的一次一密方法,给出一个对访问用户口令加密的安全实现,并成功地应用于某高校"艺术类远程招生与考试管理系统".

  15. The Design of Identity Authentication Scheme of Network Examination Based on MD5 and RSA Algorithm%基于MD5和 RSA 算法的网络考试身份认证方案设计

    Institute of Scientific and Technical Information of China (English)

    许永达

    2013-01-01

      Establishing a good identity authentication system is one of the key steps to realize the network examination security ,and tradi-tional identity authentication methods like “username + password” have a big security risk .So an identity authentication scheme based on MD5 and RSA Algorithm is proposed ,which uses the MD5 algorithm to improve the“username + password” authentication method ,and then uses the digital signature based on MD5 and RSA algorithm to further verify the user’s identity .This scheme can effectively confirm us-er identity ,and greatly enhance the safety performance of the examination system .%  建立完善的身份认证系统是实现网络考试安全的关键步骤之一,而“用户名+密码”等传统身份认证方式存在较大的安全隐患。文章提出了一种基于MD5和RSA算法的身份认证方案,先利用MD5算法来改进“用户名+密码”认证方法,再借助MD5和RSA算法实现的数字签名来进一步验证用户的身份。该方案可以高效确认用户身份,极大地增强了考试系统的安全性能。

  16. 八棱海棠MdPPO2B基因的表达及功能分析%Expression and Functional Analysis ofMdPPO2BfromMalus robusta

    Institute of Scientific and Technical Information of China (English)

    沈雪芳; 韩晴; 高建杰; 彭日荷; 王波; 高志红; 姚泉洪; 章镇

    2015-01-01

    多酚氧化酶(PPO)是一种含多个铜离子的氧化还原酶,可催化酚类物质氧化为醌类物质。我们从八棱海棠中克隆到一个PPO的同源基因MdPPO2B,构建该基因酵母分泌表达载体并转化到毕赤酵母GS115中。SDS-PAGE电泳结果显示,表达蛋白MdPPO2B的分子量约为66.4 kDa。以邻苯二酚作为底物,该酶的最适pH和温度分别为6.5和40℃。除Cu2+、Na+、Mg2+和Li+外,4 mmol·L-1的Fe3+、Zn2+、Mn2+对酶活力表现出较强的抑制作用。在最适条件下,当苯酚浓度达600μmol·L-1时,反应4 h, MdPPO2B表达菌株可降解80%的苯酚。表明该基因在工业污水处理中具有广阔的应用潜力。%Polyphenol oxidase (PPO) is one of oxidoreductase enzymes, which catalyzes the phenols to diqui-nones. A putative PPO gene (MdPPO2B) wascloned fromMalus robusta and exogenously expressed inPichia pastoris GS115. SDS-PAGE showed thatMdPPO2B has a molecular mass of approximately 66.4 kDa. With catechol as substrate, it was showed that the optimum pH and temperature forMdPPO2B was 6.5 and 40℃, respectively. Except for Cu2+, Na+, Mg2+ and Li+, Fe3+, Zn2+ and Mn2+ inhibited the enzyme activity at a concen-tration of 4 mmol·L-1. TheMdPPO2B degraded 80% phenol after incubated for 4 h under the optimum condi-tion. In short, our original research onMdPPO2B may provide reference for the application of microorganism in industrial wastewater.

  17. MD5算法及其在电视节目技术质量控制中的应用%The Application of MD5 Algorithm in TV Program Technique Quality Control System

    Institute of Scientific and Technical Information of China (English)

    刘元春

    2010-01-01

    MD5算法是一种广泛应用的典型Hash加密算法,在详细剖析MD5算法的基础上,对其基于文件电视节目技术质量控制系统中的应用,如何解决普遍存在的文件完整性检测、密码保护、越权访问、文件重复性校验、责任追溯等安全问题进行了探索.

  18. 一种基于MD5硬件Key的票据号产生方法%A method of Produced Notes Number With MD5 Algorithm and IKey

    Institute of Scientific and Technical Information of China (English)

    谢琦; 杨文娜

    2009-01-01

    文章讨论了一种基于加密处理器的商业票据产生方法,介绍了采用多个母密钥片断产生MD5密钥的算法,以及密钥在加密处理器中的存储和管理方式,并给出了基于MD5算法产生票据号的实现方法和试验结果.

  19. MD Simulations on a Flexible Chain Polyethylene: the Effect of the Electrostatic Forces in the Density-Temperature Behavior

    CERN Document Server

    Kretov, D A

    2004-01-01

    Molecular Dynamics (MD) simulations have been performed on the parallel-vector and special-purposes MD machines to study the dynamical behaviors of a flexible polyethylene (PE) chain subjected to various heating conditions. Both the effect of the short-range and electrostatic interactions on the dynamics of the PE system were estimated and compared. For this purpose three different simulations were performed regarding on the following regimes: fast, moderate and slow heating processes. The peculiarities of the main thermodynamic quantities of the system were estimated in detail and compared for all three processes. Molecular mechanical and MD calculations on the PE system were performed using the optimized version of the DL_POLY code, adapted for the vector- and special-purpose MDGRAPE-2 machines.

  20. 25 ns studies in the LHC – MD held on 14/10/2011

    CERN Document Server

    Arduini, G; Biancacci, N; Buffat, X; Dominguez, O; Iadarola, G; Métral, E; Rumolo, G; Salvant, B; Zannini, C; Roncarolo, F; Esteban Muller, JF; Höfle, W; Shaposhnikova, E; Valuch, D; Cettour-Cave, S; Kain, V; Redaelli, S; Barnes, M; Bartmann, W; Bracco, C; Goddard, B; Claudet, S; Tavian, L; Baglin, V; Bregliozzi, G; Kersevan, R; Lanza, G

    2012-01-01

    The machine development session (12 hours) was devoted to the injection of several trains of 72 bunches with nominal bunch population and 25 ns bunch spacing with the aim of injecting up to 1000 bunches/beam. This was the third of a series MD periods (in total 72 hours were requested at the beginning of the year) dedicated to electron cloud and scrubbing studies with 25 ns beams. The first one (8 hours on 26/08/2011) was lost due to a cryogenics problem. The second (12 hours) took place on 6/10/2011 and was mostly dedicated to the setting-up of the injection and of the transverse damper.

  1. MD simulation and cluster analyses of the gas permeability of parylene AF4 membranes

    Science.gov (United States)

    Bian, Liang; Shu, Yuan-jie; Song, Mian-xin; Dong, Fa-qin; Li, Wei-min; Xu, Jinbao; Zhang, Xiao-yan

    2016-02-01

    In poly-p-xylylene (parylene) AF4 membranes, amorphous and crystalline areas were constructed by a novel computational technique: a combination of NVT + NPT-molecular dynamics (MD) and "gradually reduce the size" (GRS) methods. The corresponding free volume was determined via the homology cluster method. Crystalline parylene AF4 membranes were found to provide less free volume for the adsorption and transfer of gases than amorphous parylene AF4. The permeability results showed that amorphous and crystalline parylene AF4 membranes have different permeation properties, and the corresponding permeability coefficients approach those observed experimentally. This work determined the behaviours and directions of diffusing gases via a cluster analysis technique. Gas diffusion occurs only along the y-axis in the crystalline area and randomly in the amorphous area. The relative permeability was close to the experimental value.

  2. pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins.

    Directory of Open Access Journals (Sweden)

    Priyanka Prakash

    2015-10-01

    Full Text Available Probe-based or mixed solvent molecular dynamics simulation is a useful approach for the identification and characterization of druggable sites in drug targets. However, thus far the method has been applied only to soluble proteins. A major reason for this is the potential effect of the probe molecules on membrane structure. We have developed a technique to overcome this limitation that entails modification of force field parameters to reduce a few pairwise non-bonded interactions between selected atoms of the probe molecules and bilayer lipids. We used the resulting technique, termed pMD-membrane, to identify allosteric ligand binding sites on the G12D and G13D oncogenic mutants of the K-Ras protein bound to a negatively charged lipid bilayer. In addition, we show that differences in probe occupancy can be used to quantify changes in the accessibility of druggable sites due to conformational changes induced by membrane binding or mutation.

  3. An novel architecture for information hiding using HMAC-MD5

    Directory of Open Access Journals (Sweden)

    Agilandeeswari Loganathan

    2013-03-01

    Full Text Available Communication in digital form has become the part of day today’s lifestyle, in certain moment communication is made secret to avoid others from knowing the information. By providing security to the sensitive data it is ensured that the user’s data is protected from viewing and accessing by others. In the current discussion about data security, Steganographic algorithm using two mediums has been discussed that involves image based encryption and converting to word file. The stage involving image based encryption uses HMAC-MD5 algorithm along with LSB steganography. LSB technique scatters the secret data which have to be protected over the entire image. Convert the embedded image in word file, so that the secret message is made unavailable to others who try to obtain the file. This method provides greater payload capacity along with higher image fidelity and thus make the proposed system is more robust against attacks. 

  4. Static and dynamic properties of confined, cold ion plasmas: MD (molecular dynamics) simulations

    Energy Technology Data Exchange (ETDEWEB)

    Schiffer, J.P.

    1989-01-01

    Some four years ago it was suggested that in the new generation of heavy ion accelerator storage rings for multiply charged ions, being planned in Europe, one may well attain internal temperatures that would correspond to very cold plasmas. Since that time, the techniques of electron or laser cooling of such beams has evolved and it may well be possible to reach temperatures corresponding to a plasma coupling parameter {Gamma} >> 100. I was fortunate to have had an opportunity to collaborate during 1986-87 with my former colleague Aneesur Rahman, of Molecular Dynamics fame, and we adapted the MD method to the calculation of the properties of cold confined plasmas. After Rahman's premature death two years ago I have continued the exploration of these systems and would like to summarize the results here. 9 refs., 10 figs.

  5. Extension of the M-D model for treating stress drops in salt

    Energy Technology Data Exchange (ETDEWEB)

    Munson, D.E. [Sandia National Labs., Albuquerque, NM (United States); DeVries, K.L.; Fossum, A.F.; Callahan, G.D. [RE/SPEC Inc., Rapid City, SD (US)

    1993-07-01

    Development of the multimechanism deformation (M-D) constitutive model for steady state creep, which incorporates irreversible workhardening and recovery transient strains, was motivated by the need to predict very long term closures in underground rooms for radioactive waste repositories in salt. The multimechanism deformation model for the creep deformation of salt is extended to treat the response of salt to imposed stress drops. Stress drop tests produce a very distinctive behavior where both reversible elastic strain and reversible time dependent strain occur. These transient strains are negative compared to the positive transient strains produced by the normal creep workhardening and recovery processes. A simple micromechanical evolutionary process is defined to account for the accumulation of these reversible strains, and their subsequent release with decreases in stress. A number of experimental stress drop tests for various stress drop magnitudes and temperatures are adequately simulated with the model.

  6. Extension of the M-D model for treating stress drops in salt

    International Nuclear Information System (INIS)

    Development of the multimechanism deformation (M-D) constitutive model for steady state creep, which incorporates irreversible workhardening and recovery transient strains, was motivated by the need to predict very long term closures in underground rooms for radioactive waste repositories in salt. The multimechanism deformation model for the creep deformation of salt is extended to treat the response of salt to imposed stress drops. Stress drop tests produce a very distinctive behavior where both reversible elastic strain and reversible time dependent strain occur. These transient strains are negative compared to the positive transient strains produced by the normal creep workhardening and recovery processes. A simple micromechanical evolutionary process is defined to account for the accumulation of these reversible strains, and their subsequent release with decreases in stress. A number of experimental stress drop tests for various stress drop magnitudes and temperatures are adequately simulated with the model

  7. Diffusion of hydrocarbon in zeolite and effect due to pore topology: Neutron scattering and MD simulation studies

    Energy Technology Data Exchange (ETDEWEB)

    Mitra, S.; Sharma, V.K.; Chaplot, S.L.; Mukhopadhyay, R., E-mail: mukhop@barc.gov.in

    2014-02-17

    Highlights: • Dynamical landscape of propylene adsorbed in two different zeolites is obtained. • MD simulation indicated three different time scales for the translational motion. • Neutron scattering data correspond to one of the three different time scales. • Faster rotational motion observed in a wider energy window neutron spectrometer. • Propylene found to be in preferred orientation in ZSM5 but not in Na–Y zeolite. - Abstract: Here we report detailed dynamical landscape of propylene adsorbed in ZSM5 and Na–Y zeolites as studied by neutron scattering and molecular dynamics (MD) simulation. Separation of propylene molecule from propane in the petrochemical industry is an important issue because it is one of the most demanding energetic separation processes due to their very close relative volatilities and molecular sizes. Aim here is to investigate the correlation of the host topology towards the dynamics of guest molecules. ZSM5 zeolite is typified by a network of intersecting channels while Na–Y has a network of spherical supercages interconnected by windows. Both neutron scattering and MD simulation studies indicated that translational diffusion of propylene is more restricted in ZSM5 compared to Na–Y zeolite. Fully atomistic MD simulation studies showed that the translation involves three different time scales and rotational motion of the propylene is much faster than translation. The observed dynamics in QENS spectrometer (ΔE ∼ 200 μeV) corresponds to one of the three translational components indicated in the MD simulation. The faster rotational motion is observed in a wider energy window spectrometer (ΔE ∼ 3 meV). MD simulation results also show some interesting features like, non-isotropic rotation in ZSM5 while it has been isotropic in Na–Y zeolite. It is also found that propylene molecules prefer to orient along channels of ZSM5 zeolite.

  8. Enhanced performance of PVDF nanocomposite membrane by nanofiber coating: A membrane for sustainable desalination through MD.

    Science.gov (United States)

    Efome, Johnson E; Rana, Dipak; Matsuura, Takeshi; Lan, Christopher Q

    2016-02-01

    Membrane distillation (MD) is a promising separation technique capable of being used in the desalination of marine and brackish water. Poly(vinylidene fluoride) (PVDF) flat sheet nano-composite membranes were surface modified by coating with electro-spun PVDF nano-fibres to increase the surface hydrophobicity. For this purpose, the nano-composite membrane containing 7 wt.% superhydrophobic SiO2 nano-particles, which showed the highest flux in our previous work, was first subjected to pore size augmentation by increasing the concentration of the pore forming agent (Di-ionized water). Then, the prepared flat sheet membranes were subjected to nanofibres coating by electro-spinning. The uncoated and coated composite fabricated membranes were characterized using contact angle, liquid entry pressure of water, and scanning electron microscopy. The membranes were further tested for 6 h desalination by direct contact membrane distillation (DCMD) and vacuum membrane distillation (VMD), with a 3.5 wt.% synthetic NaClaq as the feed. In DCMD the feed liquid and permeate side temperature were maintained at 27.5 °C and 15 °C, respectively. For VMD, the feed liquid temperature was 27 °C and a vacuum of 94.8 kPa was applied on the permeate side. The maximum permeate flux achieved was 3.2 kg/m(2).h for VMD and 6.5 kg/m(2).h for DCMD. The salt rejection obtained was higher than 99.98%. The coated membranes showed a more stable flux than the uncoated membranes indicating that the double layered membranes have great potential in solving the pore wetting problem in MD. PMID:26630042

  9. Mapping a candidate gene (MdMYB10 for red flesh and foliage colour in apple

    Directory of Open Access Journals (Sweden)

    Allan Andrew C

    2007-07-01

    Full Text Available Abstract Background Integrating plant genomics and classical breeding is a challenge for both plant breeders and molecular biologists. Marker-assisted selection (MAS is a tool that can be used to accelerate the development of novel apple varieties such as cultivars that have fruit with anthocyanin through to the core. In addition, determining the inheritance of novel alleles, such as the one responsible for red flesh, adds to our understanding of allelic variation. Our goal was to map candidate anthocyanin biosynthetic and regulatory genes in a population segregating for the red flesh phenotypes. Results We have identified the Rni locus, a major genetic determinant of the red foliage and red colour in the core of apple fruit. In a population segregating for the red flesh and foliage phenotype we have determined the inheritance of the Rni locus and DNA polymorphisms of candidate anthocyanin biosynthetic and regulatory genes. Simple Sequence Repeats (SSRs and Single Nucleotide Polymorphisms (SNPs in the candidate genes were also located on an apple genetic map. We have shown that the MdMYB10 gene co-segregates with the Rni locus and is on Linkage Group (LG 09 of the apple genome. Conclusion We have performed candidate gene mapping in a fruit tree crop and have provided genetic evidence that red colouration in the fruit core as well as red foliage are both controlled by a single locus named Rni. We have shown that the transcription factor MdMYB10 may be the gene underlying Rni as there were no recombinants between the marker for this gene and the red phenotype in a population of 516 individuals. Associating markers derived from candidate genes with a desirable phenotypic trait has demonstrated the application of genomic tools in a breeding programme of a horticultural crop species.

  10. Screening of UV-B-induced genes from apple peels by SSH: possible involvement of MdCOP1-mediated signaling cascade genes in anthocyanin accumulation.

    Science.gov (United States)

    Peng, Ting; Saito, Takanori; Honda, Chikako; Ban, Yusuke; Kondo, Satoru; Liu, Ji-Hong; Hatsuyama, Yoshimichi; Moriguchi, Takaya

    2013-07-01

    Suppression subtractive hybridization (SSH) was employed to identify candidate genes involved in red coloration in apple peel with the ultraviolet (UV)-B-treated 'Mutsu'. After reverse Northern blotting verification, nearly 80 clones were successfully sequenced. Large portions of the expressed sequence tags (ESTs) are well characterized anthocyanin biosynthesis-related genes, such as chalcone synthase (11A5), flavonol synthase (12F3), anthocyanidin synthase (11H5) and UDP-glycosyl transferase (14A12) whose presence proved the success of SSH. Eight ESTs were selected for quantitative real-time polymerase chain reaction analysis and their expressions were all elevated in 'Induction', further confirming the reliability of the SSH library. One EST, 11F4 (CONSTITUTIVE PHOTOMORPHOGENIC 1: COP1) with putative function in light signal relay was further analyzed in 'Mutsu' and 'Tsugaru', along with MdHY5 (ELONGATED HYPOCOTYL 5: the downstream target of COP1), MdMYB22 (a possible flavonol-specific activator under the regulation of HY5, belonging to the SG7/PRODUCTION OF FLAVONOL GLYCOSIDES family) and MdMYBA. Results showed that MdCOP1, MdHY5, MdMYB22 and MdMYBA were all UV-B inducible genes and anthocyanin accumulation occurred after their increased expressions. Moreover, their expressions and anthocyanin content were enhanced under UV-B plus 17°C treatment. The presence of G box, a known consensus binding site of HY5, in the MdMYBA promoter region implicated that it could be regulated by MdHY5, which was verified by the result of the yeast one-hybrid analysis. Our data suggested that UV-B irradiation would induce the utmost upstream light signaling factor, MdCOP1, which activates MdHY5 signaling by binding to the promoter regions of MdMYBs, and finally leads to the red coloration of apple peels. PMID:23171407

  11. 如何使用C + + Builder多线程技术实现MD5校验

    Institute of Scientific and Technical Information of China (English)

    陈家雄

    2007-01-01

    @@ A MD5全称是Message-Digest Algorithm 5(信息-摘要算法5),广泛用于字符串的加密和文件的校验上.比如在电信、金融等一些安全等级要求极高的系统中,大多是将用户密码转换成MD5密文后再存储在数据库系统中.

  12. Design and Implementation of a Non-pipelined MD5 Hardware Architecture Using a New Functional Description

    Science.gov (United States)

    Algredo-Badillo, Ignacio; Feregrino-Uribe, Claudia; Cumplido, René; Morales-Sandoval, Miguel

    MD5 is a cryptographic algorithm used for authentication. When implemented in hardware, the performance is affected by the data dependency of the iterative compression function. In this paper, a new functional description is proposed with the aim of achieving higher throughput by mean of reducing the critical path and latency. This description can be used in similar structures of other hash algorithms, such as SHA-1, SHA-2 and RIPEMD-160, which have comparable data dependence. The proposed MD5 hardware architecture achieves a high throughput/area ratio, results of implementation in an FPGA are presented and discussed, as well as comparisons against related works.

  13. Summary of LHC MD 398: Verification of the dependence of the BCTF measurements on beam position and bunch length

    CERN Document Server

    Krupa, Michal; Gasior, Marek; Lefevre, Thibaut; Soby, Lars; CERN. Geneva. ATS Department

    2015-01-01

    The main aim of the MD was to study the dependency of bunch-by-bunch intensity measurements to beam position and bunch length variations. Large beam position offsets in IR4 and varying bunch length were introduced to compare the performance of the presently installed Fast Beam Current Transformers with the new Integrating Current Transformer and the new Wall Current Transformer. This note explains all the procedures of the LHC MD 398, which took place on 20/07/2015, and presents the obtained results.

  14. 高性能MD5算法IP核的设计空间探索与分析%Design Space Exploration and Analysis of High Performance MD5 IP Core

    Institute of Scientific and Technical Information of China (English)

    原昊; 吴东; 谢向辉

    2009-01-01

    This paper uses a high-level hardware description language called Bluespec SystemVerilog as the basic tool, takes a design space exploration of the hardware implementation of the MD5 algorithm, implements four different architec-tures, tests and analyzes the performance and area occupation of the four architectures, and gets the complete parameters of the design space for MD5 IP Cores.%本文以Bluespec SystemVerilog高层硬件描述语言为工具,对MD5核心算法进行了设计空间探索,实现了全展开组合逻辑、全展开流水线、循环迭代、流水化的循环迭代四种结构,测试和分析了各种结构的性能和面积指标,完整掌握了MD5 IP核的设计空间的各项参数.

  15. Duplicate Data Delete Technology Based on MD5 and Bloom Filter%基于MD5和布鲁姆过滤器的重复数据删除算法

    Institute of Scientific and Technical Information of China (English)

    车玉婧; 胡波; 费向东

    2011-01-01

    针对目前重复数据处理技术的低效性和不可靠性,本文提出了一种基于MD5算法和布鲁姆过滤器的重复数据删除算法。新算法采用两级布鲁姆过滤器并有效结合MDS算法的方式,在发挥布鲁姆过滤器空间效率的同时汲取了MD5算法的可靠性,使得文件级别和数据块级别的重复数据删除策略交替工作。测试分析表明,新算法性能稳定并且实现了高效且可靠的重复数据删除功能。%Aimed at the inefficiency and unreliability of the data de-duplication teclmology, a solution to this problem which based on MD5 algorithm and Bloom Filter technology is put forward in this paper.The new algorithm is the effective combination of MD5 algorithm and Bloom Filter structure.Profiting from less space occupancy of Bloom Filter and reliability of MD5 algorithm,the new algorithm can work under the alternate mode of file-level data de-duplication tactic and data-block-level data de-duplication tactic.Testing and analysis indicate that the new algorithm has achieved an efficient and secure data de-duplication function.

  16. A Comparison of the American Society of Cataract and Refractive Surgery post-myopic LASIK/PRK Intraocular Lens (IOL calculator and the Ocular MD IOL calculator

    Directory of Open Access Journals (Sweden)

    Hsu M

    2011-09-01

    Full Text Available David L DeMill1, Majid Moshirfar1, Marcus C Neuffer1, Maylon Hsu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USABackground: To compare the average values of the American Society of Cataract and Refractive Surgery (ASCRS and Ocular MD intraocular lens (IOL calculators to assess their accuracy in predicting IOL power in patients with prior laser-in-situ keratomileusis (LASIK or photorefractive keratectomy.Methods: In this retrospective study, data from 21 eyes with previous LASIK or photorefractive keratectomy for myopia and subsequent cataract surgery was used in an IOL calculator comparison. The predicted IOL powers of the Ocular MD SRK/T, Ocular MD Haigis, and ASCRS averages were compared. The Ocular MD average (composed of an average of Ocular MD SRK/T and Ocular MD Haigis and the all calculator average (composed of an average of Ocular MD SRK/T, Ocular MD Haigis, and ASCRS were also compared. Primary outcome measures were mean arithmetic and absolute IOL prediction error, variance in mean arithmetic IOL prediction error, and the percentage of eyes within ±0.50 and ±1.00 D.Results: The Ocular MD SRK/T and Ocular MD Haigis averages produced mean arithmetic IOL prediction errors of 0.57 and –0.61 diopters (D, respectively, which were significantly larger than errors from the ASCRS, Ocular MD, and all calculator averages (0.11, –0.02, and 0.02 D, respectively, all P < 0.05. There was no statistically significant difference between the methods in absolute IOL prediction error, variance, or the percentage of eyes with outcomes within ±0.50 and ±1.00 D.Conclusion: The ASCRS average was more accurate in predicting IOL power than the Ocular MD SRK/T and Ocular MD Haigis averages alone. Our methods using combinations of these averages which, when compared with the individual averages, showed a trend of decreased mean arithmetic IOL

  17. MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery

    Directory of Open Access Journals (Sweden)

    Rongzhong Li

    2015-07-01

    Full Text Available While tRNA and aminoacyl-tRNA synthetases are classes of biomolecules that have been extensively studied for decades, the finer details of how they carry out their fundamental biological functions in protein synthesis remain a challenge. Recent molecular dynamics (MD simulations are verifying experimental observations and providing new insight that cannot be addressed from experiments alone. Throughout the review, we briefly discuss important historical events to provide a context for how far the field has progressed over the past few decades. We then review the background of tRNA molecules, aminoacyl-tRNA synthetases, and current state of the art MD simulation techniques for those who may be unfamiliar with any of those fields. Recent MD simulations of tRNA dynamics and folding and of aminoacyl-tRNA synthetase dynamics and mechanistic characterizations are discussed. We highlight the recent successes and discuss how important questions can be addressed using current MD simulations techniques. We also outline several natural next steps for computational studies of AARS:tRNA complexes.

  18. QM/MD studies of the dynamics of the MTSL spin label in Aurora-A kinase protein activation loop

    CERN Document Server

    Concilio, Maria Grazia; Bayliss, Richard; Burgess, Selena

    2015-01-01

    Molecular dynamics(MD)simulations using a graphics processing unit (GPU) has been employed in order to determine the conformational space of the methane-thiosulfonate spin label (MTSL) attached to the activation loop of the Aurora-A kinase protein and compared with quantum mechanical (QM) methods rooted on density functional theory (DFT). MD provided a wealth of information about interactions between the MTSL and the residues of the protein and on the different motional contributions to the overall dynamics of the MTSL. Data obtained from MD were seen to be in good agreement with those obtained from QM but the dynamics of the system revealed more interactions than those observed from QM methods. A strong correlation between the tumbling of the protein and the transitions of the X4 and X5 dihedral angles of the MTSL, was observed with a consequent effect also the distribution of the nitroxide(NO)group in the space. Theoretical EPR spectra calculated from opportunely selected MD frames showing interactions betw...

  19. Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple.

    Science.gov (United States)

    Hu, Da-Gang; Sun, Cui-Hui; Zhang, Quan-Yan; An, Jian-Ping; You, Chun-Xiang; Hao, Yu-Jin

    2016-08-01

    Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF) MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. PMID:27560976

  20. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA),...

  1. 75 FR 65250 - Proposed Amendment of Class E Airspace and Revocation of Class E Airspace; Easton, MD

    Science.gov (United States)

    2010-10-22

    ...; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February... follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... at Easton, MD. The Easton Non-Directional Beacon (NDB) has been decommissioned and new...

  2. A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

    International Nuclear Information System (INIS)

    Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver they are the main extracellular matrix protein producing cell type and further perpetuate hepatic injury by secretion of pro-inflammatory mediators. Since LPS-mediated signaling through toll-like receptor 4 (TLR4) has been identified as key fibrogenic signal in HSCs we aimed to test TLR4 as potential target of therapy via ligand-binding soluble receptors. Incubation of human HSCs with a fusion protein between the extracellular domain of TLR4 and MD2 which binds LPS inhibited LPS-induced NFκB and JNK activation. TLR4/MD2 abolished LPS-induced secretion of IL-6, IL-8, MCP1, and RANTES in HSCs. In addition, TLR4/MD2 fused to human IgG-Fc neutralized LPS activity. Since TLR4 mutant mice are resistant to liver fibrosis, the TLR4/MD2 soluble receptor might represent a new therapeutic molecule for liver fibrogenesis in vivo

  3. Initial experience with the inspire MD C-Guard stent in the treatment of carotid artery disease.

    Science.gov (United States)

    Mazzaccaro, Daniela; Occhiuto, Maria T; Righini, Paolo; Malacrida, Giovanni; Nano, Giovanni

    2016-06-01

    One of the main issue concerning the treatment of carotid artery stenosis is about the use of stents which could offer the best navigability through the lesion and the smallest "maximum unprotected circular area", ensuring the lowest risk of neurological complication both intraprocedurally and in the long term. Recently, Inspire MD (Tel Aviv, Israel) presented the new stent Inspire MD C-Guard™, a bare-metal stent covered by a micron level mesh (MicroNet). We report our experience about the use of this novel stent in the endovascular treatment of carotid artery stenosis, with some technical considerations. Data about patients in whom the Inspire MD C-Guard was used for the treatment of carotid artery diseases were retrospectively collected and analyzed. The procedure was completed in all patients without any intraoperative complications. Postoperative course was uneventful in all cases and no complications have been recorded till now. In our limited experience, the Inspire MD C-Guard has proven to be a safe stent for the treatment of carotid artery diseases. However large studies are needed to better explain strengths and weaknesses of this device. PMID:27094426

  4. Multidetector CT (MD-CT) in the diagnosis of uncertain open globe injuries

    Energy Technology Data Exchange (ETDEWEB)

    Hoffstetter, P.; Schreyer, A.G.; Jung, E.M.; Heiss, P.; Zorger, N. [Inst. fuer Roentgendiagnostik, Universitaetsklinikum Regensburg (Germany); Schreyer, C.I.; Framme, C. [Klink und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Regensburg (Germany)

    2010-02-15

    Purpose: To evaluate the significance of multislice CT for the diagnosis of uncertain penetrating globe injuries. Materials and Methods: Based on a retrospective chart review between 2002 and 2007, we identified 59 patients presenting with severe ocular trauma with uncertain rupture of the globe due to massive subconjunctival and/or anterior chamber hemorrhage. The IOP (intraocular pressure) was within normal range in all patients. High resolution multidetector CT (MD-CT) scans (16 slice scans) with axial and coronar reconstructions were performed in all patients. The affected eye was examined for signs of penetrating injury such as abnormal eye shape, scleral irregularities, lens dislocation or intravitreal hemorrhages. Four experienced radiologists read the CT scans independently. Beside the diagnosis, the relevant morphological criteria and the optimal plane orientation (axial or coronar) were specified. The sensitivity, specificity, and negative and positive predictive value were calculated. Additionally the interobserver variability was determined by applying the Cohen's kappa test. Surgical sclera inspections were performed in all cases as a standard of reference. The evaluations of the CT examination were compared with the surgery reports. Results: 59 patients were evaluated (42 men, 17 women). The mean age was 29 years (range 7-91). In 17 patients a rupture of the globe was diagnosed during surgery. 12 of these 17 penetrating injuries (70.6%) were classified correctly by MDCT, 5 of the 17 (29.4%) were not detectable. 42 patients did not have an open globe injury. 41 of these patients were diagnosed correctly negative by MDCT, and one patient was classified false positive. This results in a sensitivity of 70% with a specificity of 98%. There was high inter-rater agreement with kappa values between 0.89-0.96. Most discrepancies were caused by wrong negative findings. The most frequent morphologic criteria for open globe injury were the deformation (n

  5. REVIEW OF MD (ANATOMY EXAM PAPERS: IS THE PRESENT SYSTEM OF POSTGRADUATE EVALUATION ADEQUATE?

    Directory of Open Access Journals (Sweden)

    Pooja Jain

    2014-06-01

    Full Text Available An ideal education system is in-separable from the evaluation system. There has always been a need for an evaluation system which can determine whether predetermined educational objectives have been achieved. As an exercise last 10 years annual MD question papers (anatomy of university of Delhi were given to the residents and the Post graduate students of anatomy department, Lady Hardinge Medical College, New Delhi. The analysis of question papers reflected that the emphasis on different parts of the syllabi was not uniform. All the questions were of long and short essay type. Multiple choice questions that are based on recall and problem solving attitude of the students were not at all included. There is need to revise the pattern in which question are being asked that will develop cognitive skills and problem solving attitude among the students. An ideal question paper should give equal weight-age to different content areas/topics and it should include all analytical, objective, long and short answer type questions with an uniform marking scheme for all students. When it comes to medical education, evaluation becomes very important because here lays the responsibility of bringing out the best doctor amongst the best.

  6. QM/MD studies on graphene growth from small islands on the Ni(111) surface

    Science.gov (United States)

    Jiao, Menggai; Song, Wei; Qian, Hu-Jun; Wang, Ying; Wu, Zhijian; Irle, Stephan; Morokuma, Keiji

    2016-01-01

    the nuclei to expand the size of the growing carbon network. The growth of graphene precursors is accompanied by the corresponding changes in the bonding of nickel atoms with the precipitation of subsurface carbon atoms. This is because the carbon-carbon interaction is stronger than the nickel-carbon interaction. In the case of high carbon nucleation densities, the dominant ripening mechanism depends on different growth stages. In the initial stage, the coalescence of carbon islands takes place via the Smoluchowski ripening mechanism. In the later stage the Smoluchowski ripening process is damped owing to the higher diffusion barrier of larger clusters and the restriction of movement by self-assembled nickel step edges. The cross-linking mechanism eventually takes over by the coalescence of extended polyyne chains between graphene islands. In either case, the Ostwald ripening process is not found in our molecular dynamics simulations due to the stability of carbon-carbon bonds within the islands. These investigations should be instructive to the control of graphene growth in experiments. Electronic supplementary information (ESI) available: There are two movies showing the simulation process and they are provided in separate files. Movie S1 is the evolution of QM/MD simulations of the growth of graphene from one C13 on the Ni(111) surface for trajectory D@C13. Movie S2 is the evolution of QM/MD simulations of the growth of graphene from two C13 species on the Ni(111) surface for trajectory C@2C13. Fig. S1 shows the optimized geometries of C13-G and C13-H on the Ni(111) surface. Fig. S2 is the final structures of trajectories A-J@C13 following 400 ps QM/MD simulation for the Ni(111) + C13 system. Fig. S3 is the final structures of trajectories A-J@2C13 following 350 ps QM/MD simulation for the Ni(111) + 2C13 system. Fig. S4 shows average polygonal carbon ring populations formed during graphene growth from the Ni(111) + C13 and Ni(111) + 2C13 systems. Fig. S5 shows the

  7. MD/MBA Students: An Analysis of Medical Student Career Choice

    Directory of Open Access Journals (Sweden)

    Windsor Westbrook Sherrill, Ph.D., MBA

    2004-01-01

    Full Text Available Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Methods: Students enrolled at dual degree programs at six medical schools were surveyed and interviewed. A control group of traditional medical students was also surveyed. Results: Factors influencing students to seek both medical and business training are varied but are often related to a desire for leadership opportunities, concerns about change in medicine and job security and personal career goals. Most students expect to combine clinical and administrative roles. Conclusions: Students entering these programs do so for a variety of reasons and plan diverse careers. These findings can provide guidance for program development and recruitment for dual degree medical education programs

  8. MD/MBA Students: An Analysis of Medical Student Career Choice

    Directory of Open Access Journals (Sweden)

    Windsor Westbrook Sherrill, Ph.D., MBA

    2004-01-01

    Full Text Available Background: An increasing number of medical schools are offering dual degree MD/MBA programs. Career choices and factors influencing students to enter these programs provide an indicator of the roles in which dual degree students will serve in health care as well as the future of dual degree programs. Purpose: Using career choice theory as a conceptual framework, career goals and factors influencing decisions to enter dual degree programs were assessed among dual degree medical students. Methods: Students enrolled at dual degree programs at six medical schools were surveyed and interviewed. A control group of traditional medical students was also surveyed. Results: Factors influencing students to seek both medical and business training are varied but are often related to a desire for leadership opportunities, concerns about change in medicine and job security and personal career goals. Most students expect to combine clinical and administrative roles. Conclusions: Students entering these programs do so for a variety of reasons and plan diverse careers. These findings can provide guidance for program development and recruitment for dual degree medical education program

  9. Kinetic Cooperativity, Loop Dynamics, and Allostery from NMR and MD simulations

    Science.gov (United States)

    Bruschweiler, Rafael

    The hallmark of glucokinase (GCK), which catalyzes the phosphorylation of glucose during glycolysis, is its kinetic cooperativity whose understanding at atomic detail has remained open since its discovery over 40 years ago. I will discuss how the origin of kinetic cooperativity is rooted in intramolecular protein dynamics using NMR relaxation data of 17 isoleucines distributed over all parts of GCK. Residues of glucose-free GCK located in the small domain display a distinct exchange behavior involving multiple conformers that are substantially populated, whereas in the glucose-bound form these dynamic processes are quenched. The conformational exchange process directly competes with the enzymatic turnover at physiological glucose concentrations, thereby generating the sigmoidal rate dependence that defines kinetic cooperativity. The flexible nature of protein loops and the timescales of their dynamics are critical for many biologically important events at the molecular level, such as protein interaction and recognition processes. Based on a library of proteins, rules about loop dynamics in terms of amplitude and timescales can be derived using molecular dynamics (MD) simulations and NMR data. These rules have been implemented in the new web server ToeLoop (for Timescales Of Every Loop) that permits the prediction of loop dynamics based on an average 3D protein structure (http://spin.ccic.ohio-state.edu/index.php/loop/index).

  10. Implementace a testování hashovacího algoritmu MD5

    OpenAIRE

    Legéň, Michal

    2008-01-01

    Hashovací funkce jsou jedním ze základních stavebních prvků moderní kryptografie. Jejich úkolem je pro vstupní zprávy vytvářet unikátní bitové posloupnosti, nazývané digitální otisky. Tím zabezpečují nezbytnou integritu zpráv, protože data přenášena přes různá přenosová média mohou být během přenosu pozměněna. Zároveň z důvodu jednosměrnosti poskytují možnost rychlého a účinného šifrování hesel. Cílem této bakalářské práce je analyzovat jednu z nejznámějších hashovacích funkcí MD5, implemento...

  11. Results on nominal collimator settings MD at 4 TeV

    CERN Document Server

    Salvachua, B; Burov, A; Bruce, R; Cauchi, M; Deboy, D; Lari, L; Marsili, A; Metral, E; Mounet, N; Redaelli, S; Salvant, B; Valentino, G; Previtali, V

    2012-01-01

    The goal of the MD performed on June 24th 2012 was to achieve the nominal 7 TeV settings in mm with nominal single bunch intensities using centers from the beam-based alignment of March 2012. The secondary collimators and absorbers in IR7 and the dump protection collimators were moved in from the current operational, ”tight” settings to the equivalent 7 TeV nominal settings in mm at 4 TeV, which are tighter than the current settings except for the TCPs. The performance of the nominal settings was investigated through loss maps using the ADT method to blow-up the beam. The loss maps showed a good cleaning in the dispersion suppressor regions for both beams. However, the cleaning hierarchy in beam 1 was not preserved. We tried to restore the hierarchy by re-aligning a sub-set of collimators in IR7 but no significant improvement was found. In addition, measurements on the transverse betatron tune shift during collimator movements were done in order to compare with the transverse impedance model in 2 cases: a...

  12. Leo Eitinger MD: tribute to a Holocaust survivor, humane physician and friend of mankind.

    Science.gov (United States)

    Chelouche, Tessa

    2014-04-01

    Born in Czechoslovakia, psychiatrist Leo Eitinger (1912-1996) became internationally recognized for research on his fellow concentration camp inmates. He graduated as an MD in 1937, but being Jewish was prohibited from practicing as a doctor. When the Nazis occupied the area he was forced to flee to Norway, where in 1940 he was again deprived of his right to practice medicine. In 1942 he was arrested and deported to Auschwitz. There, as a physician inmate, he was able to help and in many cases save his fellow prisoners, not only with his medical skills but by falsifying prisoners' documents and hiding them from their Nazi captors. One of his patients was Elie Wiesel. Eitinger survived the camps but was forced to join a "death march." After the war he resumed medical practice in Norway, specializing in psychiatry. With his personal experience and knowledge of the suffering of camp survivors, he dedicated his life to studying the psychological effects of traumatic stress in different groups. Eitinger's academic contributions were crucial in the development of this area of research--namely, the effects of excessive stress, laying the foundations for the definition of post-traumatic stress disorder and the post-concentration camp syndrome, thus facilitating recognition of the medical and psychological post-war conditions of the survivors and their resultant disability pensions. PMID:24834755

  13. QM/MM MD simulations of La(III)-phosphopeptide complexes.

    Science.gov (United States)

    Messner, Christoph B; Bonn, Günther K; Hofer, Thomas S

    2015-01-01

    Several bioanalytical enrichment techniques are based on the interactions of phosphopeptides with Ln(III) ions. In order to gain an improved understanding of these complexes and the respective ion-peptide interactions, hybrid quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) simulations of La(III) coordinating to the phosphopeptide VPQLEIVPNSpAEER were conducted. Simulations of di- as well as monoanionic phosphate groups were carried out. The La(III) ion and its first hydration layer, including the sidechain of the phosphoserine residue were treated quantum mechanically at RI-MP2/triple zeta level, whereas the remaining part of the system was treated with classical potentials. The simulation of the dianionic phosphopeptide revealed a 9-fold coordinated La(III) ion, with the phosphopeptide binding bi- as well as monodentate. The mean residence times (τ) of the first shell water molecules were 82 ps and 37 ps for the bi- and monodentate complexes, respectively, which is much higher compared to free La(III) in aqueous solution (τ=17 ps). The simulation of the monoanionic La(III)-phosphopeptide complex revealed a bidentate coordination throughout the 80 ps sampling period. An intramolecular hydrogen bond between the hydrogen of the phosphate group and the backbone was observed and a τ value of 14 ps was obtained, which is much lower as for the dianionic complex. PMID:25361442

  14. Presentation of the 2007 Richard S. Hodes, M.D. Honor Lecture Award

    International Nuclear Information System (INIS)

    Perma-Fix Environmental Services, Inc. Chief Operating Officer Larry McNamara is the 2007 recipient of the distinguished Richard S. Hodes, M.D. Honor Lecture Award from the Southeast Compact Commission for Low-Level Radioactive Waste Management. This award recognizes Mr. McNamara's innovation in the commercialization of mixed waste treatment processes for the nuclear industry, and the significant role that these innovations have played solving low-level radioactive waste (LLRW) management problems in the United States with specific emphasis on low-level mixed wastes. Low-level mixed wastes (LLMW) have historically been the most difficult wastes to treat because of the specialized equipment, permits and experience needed to deal with a large variety of hazardous constituents. Prior to innovations in the mixed waste treatment industry championed by Mr. McNamara, wastes were stored at generator sites around the country in regulated storage areas, at great cost, and in many cases for decades. In this paper, Mr. McNamara shares lessons he has learned over the past seven years in developing and implementing innovative waste management solutions that have helped solve one of the nation's biggest challenges. He also describes the future challenges facing the industry. (authors)

  15. Initiating tumor banking for translational research: MD Anderson and Liverpool experience.

    Science.gov (United States)

    Mishra, A; Pandey, A; Shaw, R

    2007-01-01

    The ultimate progress in the cancer diagnosis and therapy has only been possible with the ongoing translational research that is likely to play a very important role in future as well. Hence the importance of such translation from bedside to bench and vis versa cannot be over-emphasized. Accordingly it has become more important to collect tumor samples along with the clinical information in a systematic manner to perform a good basic science research in future. With a population of over a billion and a heavy burden of cancer, India has the 'biggest' potential to establish the 'largest' tumor bank across the globe. Establishing a tumor bank involves money and manpower that may not be feasible across most of the centers in India. Taking into the considering the model of tumor banking of the two leading institutions of the world (MD Anderson Cancer Center, USA and University Hospital Aintree, Liverpool UK), this article presents the salient tips for a center in India to get started with tumor banking with minimal investment. Furthermore a simplified form of ethical consent is presented for the centers to adapt unanimously. PMID:17401220

  16. Distribution of Drug Molecules in Lipid Membranes: Neutron Diffraction and MD Simulations.

    Science.gov (United States)

    Boggara, Mohan; Mihailescu, Ella; Krishnamoorti, Ramanan

    2009-03-01

    Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. Aspirin and Ibuprofen, with chronic usage cause gastro intestinal (GI) toxicity. It has been shown experimentally that NSAIDs pre-associated with phospholipids reduce the GI toxicity and also increase the therapeutic activity of these drugs compared to the unmodified ones. In this study, using neutron diffraction, the DOPC lipid bilayer structure (with and without drug) as well as the distribution of a model NSAID (Ibuprofen) as a function of its position along the membrane normal was obtained at sub-nanometer resolution. It was found that the bilayer thickness reduces as the drug is added. Further, the results are successfully compared with atomistic Molecular Dynamics simulations. Based on this successful comparison and motivated by atomic details from MD, quasi-molecular modeling of the lipid membrane is being carried out and will be presented. The above study is expected to provide an effective methodology to design drug delivery nanoparticles based on a variety of soft condensed matter such as lipids or polymers.

  17. Research on Security Application of MD5 Algorithm in Web System%MD5算法在Web系统中的安全性应用研究

    Institute of Scientific and Technical Information of China (English)

    杨玉军; 杨夷梅

    2009-01-01

    安全问题是基于Web系统普遍存在的问题,也是一个很难解决的问题,该文对目前的Web系统面临的安全问题进行了分析,介绍了MD5算法,把MD5算法应用于Web系统中,解决了目前Web系统普通存在的密码保护、信息完整性和越权访问等安全问题,并给出了具体实现方法,最终达到构建更安全的Web系统的目的.

  18. MD5 Algorithm in Data Security and Safety of the Application%MD5算法在数据安全中的应用及安全性分析

    Institute of Scientific and Technical Information of China (English)

    孙维国; 李浩然

    2010-01-01

    随着互联网技术的发展,数据的安全性、可用性和完整性保护已经变得越来越重要.MD5算法是在计算机安全领域广泛使用的一种散列函数,可以为任意长度的报文产生一段等长的信息摘要,并且具有单向加密的特性.本文分析了MD5算法的工作原理及其在数据安全中的应用,对其安全性进行了分析,并提出了一些改进的方案.

  19. 基于 MD5 数据库加密算法在综合业务平台中的应用研究%MD5 Encryption Algorithm Based on the Database Business in the Composite Application Platform

    Institute of Scientific and Technical Information of China (English)

    刘晓楠; 严承华

    2008-01-01

    对基于 MD5 和 Blowfish 加密算法的数据库进行了研究,首先对数据库加密系统结构进行了分析,然后利用MD5 加密算法对用户密码字段进行加密,利用 Blowfish 加密算法对存储在数据库巾的敏感数据进行加密,通过在综合业务平台中的应用表现,能够使加/解密过程不影响数据库运行性能,州时提高了数据库的安全性能.

  20. 基于MD5算法和Logistic映射的图像加密方法研究%Image Encryption Algorithm Based on MD5 Algorithm and Logistic Map

    Institute of Scientific and Technical Information of China (English)

    李进; 徐红

    2011-01-01

    文章提出一种基于MD5算法和Logistic映射新的图像加密方法,首先通过Logistic映射和MD5算法生成像素位置置乱表,由位置置乱表对图像进行位置置乱;然后利用Logistic映射生成二维混沌矩阵,通过混沌矩阵对图像进行灰度置乱.实验结果表明,该方法能有效地实现图像加密,并对密钥有较强的敏感性,抵御攻击的能力强.

  1. A Preliminary Analysis of the Theoretical and Application Value of the MD--EW Framework Based Classroom%浅析MD-EW架构课堂的理论及应用价值

    Institute of Scientific and Technical Information of China (English)

    秦帅

    2011-01-01

    Students and teachers always use interactive electronie whiteboard and smart mobile devices at the same time. So people think about some new teaching methods both include interactive electronic whiteboard and smart mobile devices MD-EW (Mobile Device Electronic Whiteboard)framework is increasingly feasible for us to build a new type of classroom, which has a central device- electronic whiteboard and some other interactive tools-smart mobile devices. This classroom will be an expansion of the traditional classroom,and it shows some ideas of mobile learning. Through analysis we can see that it is a good try of conjunctive use of electronic whiteboard and mobile devices.%电子白板和移动设备的使用时常发生交汇,引发了人们对新型教学应用技巧的思考。以电子白板为教学服务核心,使用移动设备作为学生端交互工具的新型课堂架构(MD-EW架构)应运而生。MD-EW架构的课堂实现了从传统课堂到微型移动课堂的扩展,体现了泛在学习和移动学习的理念,是电子白板与智能移动设备联合应用的一次有益尝试。

  2. MD5算法在J2EE平台下用户管理系统中的应用%Application of MD5 algorithm based on J2EE in user management system

    Institute of Scientific and Technical Information of China (English)

    王金柱; 李元诚

    2008-01-01

    MD5是目前在加密领域应用最为广泛的哈希函数.通过研究基于J2EE平台和B/S模式的用户管理系统的基本原理和实现方法,详细说明了基于MVC架构的系统模型,具体阐述了基于MD5进行口令密码校验的原理以及基于Java语言的算法实现.在设计口令密码校验过程中,描述了如何基于Servlet技术生成目前十分流行的图形认证码的方法.最后探讨了应用MD5算法加强Web应用中安全机制的方法和策略.

  3. The application and implementatio of MD5 encryption algorithm in the anthentication of the user management system based on LDAP%MD5算法在统一用户管理系统中身份认证的应用

    Institute of Scientific and Technical Information of China (English)

    郑之华

    2012-01-01

    This paper describes the MD5 encryption algorithm and its working principle, puts forward the application and implementatio of MD5 encryption algorithm in the anthentication of the user management system based on LDAP, and suggestions for improvement ideas.%介绍了MD5加密算法及其工作原理,提出了MD5在基于LDAP的统一用户管理系统中身份认证的应用和实现,并提出了改进思想。

  4. Ionization dynamics of the water trimer: A direct ab initio MD study

    Energy Technology Data Exchange (ETDEWEB)

    Tachikawa, Hiroto, E-mail: hiroto@eng.hokudai.ac.jp [Division of Materials Chemistry, Graduate School of Engineering, Hokkaido University, Kita-ku, Sapporo 060-8628 (Japan); Takada, Tomoya [Department of Material Chemistry, Asahikawa National College of Technology, Syunkodai, Asahikawa 071-8142 (Japan)

    2013-03-29

    Highlights: ► We calculated ionization dynamics of water trimer. ► Direct ab initio molecular dynamics (MD) method is applied. ► Proton transfer dynamics were discussed. ► The proton transfer process calculated are well reproduced in recent experiments. - Abstract: Ionization dynamics of the cyclic water trimer (H{sub 2}O){sub 3} have been investigated by means of direct ab initio molecular dynamics (AIMD) method. Two reaction channels, complex formation and OH dissociation, were found following the ionization of (H{sub 2}O){sub 3}. In both channels, first, a proton was rapidly transferred from H{sub 2}O{sup +} to H{sub 2}O (time scale is ∼15 fs after the ionization). In complex channel, an ion–radical contact pair (H{sub 3}O{sup +}–OH) solvated by the third water molecule was formed as a long-lived H{sub 3}O{sup +}(OH)H{sub 2}O complex. In OH dissociation channel, the second proton transfer further takes place from H{sub 3}O{sup +}(OH) to H{sub 2}O (time scale is 50–100 fs) and the OH radical is separated from the H{sub 3}O{sup +}. At the same time, the OH dissociation takes place when the excess energy is efficiently transferred into the kinetic energy of OH radical. The OH dissociation channel is significantly minor, and almost all product channels were the complex formation. The reaction mechanism was discussed on the basis of theoretical results.

  5. Hygrosopicity measurements of aerosol particles in the San Joaquin Valley, CA, Baltimore, MD, and Golden, CO

    Science.gov (United States)

    Orozco, Daniel; Beyersdorf, A. J.; Ziemba, L. D.; Berkoff, T.; Zhang, Q.; Delgado, R.; Hennigan, C. J.; Thornhill, K. L.; Young, D. E.; Parworth, C.; Kim, H.; Hoff, R. M.

    2016-06-01

    Aerosol hygroscopicity was investigated using a novel dryer-humidifier system, coupled to a TSI-3563 nephelometer, to obtain the light scattering coefficient (σscat) as a function of relative humidity (RH) in hydration and dehydration modes. The measurements were performed in Porterville, CA (10 January to 6 February 2013), Baltimore, MD (3-30 July 2013), and Golden, CO (12 July to 10 August 2014). Observations in Porterville and Golden were part of the NASA-sponsored Deriving Information on Surface Conditions from Column and Vertically Resolved Observations Relevant to Air Quality project. The measured σscat under varying RH in the three sites was combined with ground aerosol extinction, PM2.5 mass concentrations, and particle composition measurements and compared with airborne observations performed during campaigns. The enhancement factor, f(RH), defined as the ratio of σscat(RH) at a certain RH divided by σscat at a dry value, was used to evaluate the aerosol hygroscopicity. Particles in Porterville showed low average f(RH = 80%) (1.42) which was attributed to the high carbonaceous loading in the region where residential biomass burning and traffic emissions contribute heavily to air pollution. In Baltimore, the high average f(RH = 80%) (2.06) was attributed to the large contribution of SO42- in the region. The lowest water uptake was observed in Golden, with an average f(RH = 80%) = 1.24 where organic carbon dominated the particle loading. Different empirical fits were evaluated using the f(RH) data. The widely used Kasten (gamma) model was found least satisfactory, as it overestimates f(RH) for RH fit with two power law curve fitting parameters c and k was found to replicate f(RH) accurately from the three sites. The relationship between the organic carbon mass and the species that are affected by RH and f(RH) was also studied and categorized.

  6. A QM/MM-MD study on protein electronic properties: Circular dichroism spectra of oxytocin and insulin

    International Nuclear Information System (INIS)

    A QM/MM (quantum-mechanical/molecular-mechanical) molecular-dynamics approach based on the generalized hybrid-orbital (GHO) method, in conjunction with the second-order perturbation (MP2) theory and the second-order approximate coupled-cluster (CC2) model, is employed to calculate electronic property accounting for a protein environment. Circular dichroism (CD) spectra originating from chiral disulfide bridges of oxytocin and insulin at room temperature are computed. It is shown that the sampling of thermal fluctuation of molecular geometries facilitated by the GHO-MD method plays an important role in the obtained spectra. It is demonstrated that, while the protein environments in an oxytocin molecule have significant electrostatic influence on its chiral center, it is compensated by solvent induced charges. This gives a reasonable explanation to experimental observations. GHO-MD simulations starting from different experimental structures of insulin indicate that existence of the disulfide bridges with negative dihedral angles is crucial.

  7. MD456: Monitoring of abort gap population with diamond particle detectors at the BGI in IP 4

    CERN Document Server

    Stein, Oliver

    2016-01-01

    In this MD, diamond based particle detectors (dBLM) were used for measuring showers of the beam interactions with the in the BGI induced neon gas. This setup was proposed in a feasibility study for using dBLMs at the BGI to measure the abort gap population by detecting the beam gas interactions. During the MD neon gas was induced in the BGI vacuum chamber to increase the interaction rate. Two nominal bunches were injected and accelerated up to 6.5 TeV. The measurements lasted for 140 minutes. The bunches could be clearly identified. But the resulting count rate of the beam gas interactions was a factor 70 lower than predicted by the feasibility study. In addition, a problem with the timing information lead to a widening of the histogram peaks.

  8. A QM/MM-MD study on protein electronic properties: Circular dichroism spectra of oxytocin and insulin

    Energy Technology Data Exchange (ETDEWEB)

    Kitagawa, Yuya [Graduate School of System Informatics, Kobe University, Kobe 657-8501 (Japan); CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012 (Japan); Akinaga, Yoshinobu [RIKEN Advanced Institute for Computational Science, Kobe 650-0047 (Japan); Kawashima, Yukio [Department of Chemistry, Graduate School of Sciences, Kyushu University, Fukuoka 812-8581 (Japan); Institute of Advanced Research, Kyushu University, Fukuoka 812-8581 (Japan); Jung, Jaewoon [RIKEN Advanced Institute for Computational Science, Kobe 650-0047 (Japan); Ten-no, Seiichiro, E-mail: tenno@cs.kobe-u.ac.jp [Graduate School of System Informatics, Kobe University, Kobe 657-8501 (Japan); CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012 (Japan)

    2012-06-05

    A QM/MM (quantum-mechanical/molecular-mechanical) molecular-dynamics approach based on the generalized hybrid-orbital (GHO) method, in conjunction with the second-order perturbation (MP2) theory and the second-order approximate coupled-cluster (CC2) model, is employed to calculate electronic property accounting for a protein environment. Circular dichroism (CD) spectra originating from chiral disulfide bridges of oxytocin and insulin at room temperature are computed. It is shown that the sampling of thermal fluctuation of molecular geometries facilitated by the GHO-MD method plays an important role in the obtained spectra. It is demonstrated that, while the protein environments in an oxytocin molecule have significant electrostatic influence on its chiral center, it is compensated by solvent induced charges. This gives a reasonable explanation to experimental observations. GHO-MD simulations starting from different experimental structures of insulin indicate that existence of the disulfide bridges with negative dihedral angles is crucial.

  9. House M.D.: the monitoring of life, crime and disease in the age of its technical visuality

    Directory of Open Access Journals (Sweden)

    Ivana Bentes

    2011-12-01

    Full Text Available When the body, the subjectivity and disease are converted into medical information, statistics and ballistics, MRI, contrasts, maps and images, they appear as new actors and dramatic elements in contemporary fiction, especially in series as House M.D. and CSI. In this article, we analyze some House M.D. episodes, highlighting how these body visualization technologies, genetic mapping, diagnostics, monitoring procedures, equipment for production of evidences of every kind (medical and criminal are co-actors in these dramas. Technological devices and information surpass the experts’ domain and turn into a new form of entertainment, becoming vital games that mobilize specialists and amateurs. In these games we see a gradual status change from the patient or the victim, turned into participant, inter-actor, and co-director of his disease, his suffering or his crime.

  10. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD virus in tissues from aborted ruminant foetuses using immunohistochemistry

    Directory of Open Access Journals (Sweden)

    S.M. Njiro

    2009-05-01

    Full Text Available Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP. Diaminobenzidine (DAB was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC procedure. Of 27 aborted foetuses, an immunoperoxidase staining reaction was observed in 1 ovine and 5 bovine foetuses. The IHC procedure located BVD/MD viral antigen in a wide variety of foetal tissues including cerebral cortical neurons, the pseudostratified columnar epithelial cells lining the bronchi, alveolar lining cells and alveolar macrophages, hepatocytes, renal tubular lining cells and the Purkinje fibres in the myocardium.

  11. Payer Perspectives on PCSK9 Inhibitors: A Conversation with Stephen Gorshow, MD, and James T. Kenney, RPh, MBA

    OpenAIRE

    Mehr, Stanton R.

    2016-01-01

    The new proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can have significant budget effects, depending on the breadth of the US Food and Drug Administration (FDA)'s approved labeling. American Health & Drug Benefits asked Stephen Gorshow, MD, Regional Medical Director, UnitedHealthcare, and James T. Kenney, RPh, MBA, Manager, Specialty and Pharmacy Contracts, Harvard Pilgrim Health Care, to participate in a teleconference to better understand how payers are approaching the ma...

  12. A 1966 Anesthetic Administered by Robert D. Dripps, M.D., Demonstrated His Experimental Style of Clinical Care.

    Science.gov (United States)

    Johnstone, Robert E; Fleisher, Lee A

    2016-06-01

    Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administration of each anesthetic a research study. Intense public criticism in 1967 for improper experimentation on patients during anesthesia changed his clinical and research philosophies and teaching. PMID:27028470

  13. Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

    Science.gov (United States)

    O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

    2015-02-01

    The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce. PMID:25354071

  14. MD 755: Instability threshold and tune shift study with reduced retraction between primary and secondary collimators in IR7

    CERN Document Server

    Carver, Lee Robert; Mereghetti, Alessio; Bruce, Roderik; Metral, Elias; Salvant, Benoit; Nisbet, David; Redaelli, Stefano; Salvachua Ferrando, Belen Maria; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to quantify in terms of stabilising octupole current threshold the impedance change when reducing the retraction between the primary and secondary collimators in IR7. This will be performed by first measuring the octupole current threshold required for stability with the tighter secondary collimator settings at 6.5 (w.r.t. to the nominal settings at 8 ), and then measuring the tune shift that occurs when the collimators are moved to the new settings.

  15. Detection of the bovine viral diarrhoea / mucosal disease (BVD/MD) virus in tissues from aborted ruminant foetuses using immunohistochemistry

    OpenAIRE

    S. M. Njiro; C.M. Nkosi

    2009-01-01

    Various tissues from aborted ruminant foetuses were collected, fixed in formalin and embedded in paraffin wax. Sections were made and exposed to a primary monoclonal antibody against the bovine viral diarrhoea / mucosal disease (BVD/MD) virus, and subsequently to a goat anti-mouse secondary antibody conjugated to horse radish peroxidase (HRP). Diaminobenzidine (DAB) was the substrate and it released a brown pigment in the tissues on reacting with the HRP in an immunohistochemistry (IHC) proce...

  16. MD5报文摘要算法与IPv6认证%MESSAGE DIGEST 5 AND THE AUTHENTICATION IN IPv6

    Institute of Scientific and Technical Information of China (English)

    王贵竹; 李津生; 洪佩琳

    2001-01-01

    Message digest 5 is a widely used algorithm, which can extract finger-print from message. The keyed MD5 is the default authentication algorithm in IPv6. In this paper, IPv6 header format and authentication header format are studied and the principle of MD5 is carefully analyzed. The authentication mechanism using MD5 in IPv6 is also studied in this paper.%MD5报文摘要算法是一种应用广泛的提取数字指纹的算法.在IPv6中定义带密钥的MD5算法为其默认的认证算法.本文分析了IPv6的基本头标和认证头标的格式,详细剖析了MD5算法的工作原理,以及在IPv6中引入MD5作为其默认认证算法的方法.

  17. 基于MD5加密算法的系统安全登录研究

    Institute of Scientific and Technical Information of China (English)

    孙杨

    2013-01-01

      现在许多业务系统都是基于网络环境的,虽然满足了系统应用方便,共享性好的要求,但同时在系统安全上也带来了一些问题。如何消除安全隐患,增强登录模块的安全性,这是摆在系统建设者面前的一道课题。MD5即Me ssage-Digest Algorithm 5(信息-算法5),用于确保信息传输完整一致,是计算机广泛使用的杂凑算法之一(又译算法、哈希算法),主流编程语言普遍已有MD5实现。系统可以借助MD5算法来强化安全措施,避免权限外用户浏览信息,从而提高业务系统的保密性。

  18. Hemochromatosis

    Science.gov (United States)

    ... status in the general Mediterranean population from Tarragona, Spain. Annals of Hematology. 2010;89(8):767–773. ... thank: Bruce R. Bacon, M.D., St. Louis University School of Medicine, Anthony Tavill, M.D., Case ...

  19. Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations

    International Nuclear Information System (INIS)

    The role of dynamics in protein functions including signal transduction is just starting to be deciphered. Eph receptors with 16 members divided into A- and B- subclasses are respectively activated by 9 A- and B-ephrin ligands. EphA4 is the only receptor capable of binding to all 9 ephrins and small molecules with overlapped interfaces. We first determined the structures of the EphA4 ligand binding domain (LBD) in two crystals of P1 space group. Noticeably, 8 EphA4 molecules were found in one asymmetric unit and consequently from two crystals we obtained 16 structures, which show significant conformational variations over the functionally critical A-C, D-E, G-H and J-K loops. The 16 new structures, together with previous 9 ones, can be categorized into two groups: closed and open forms which resemble the uncomplexed and complexed structures of the EphA4 LBD respectively. To assess whether the conformational diversity over the loops primarily results from the intrinsic dynamics, we initiated 30-ns molecular dynamics (MD) simulations for both closed and open forms. The results indicate that the loops do have much higher intrinsic dynamics, which is further unravelled by NMR H/D exchange experiments. During simulations, the open form has the RMS deviations slightly larger than those of the closed one, suggesting the open form may be less stable in the absence of external contacts. Furthermore, no obvious exchange between two forms is observed within 30 ns, implying that they are dynamically separated. Our study provides the first experimental and computational result revealing that the intrinsic dynamics are most likely underlying the conformational diversity observed for the EphA4 LBD loops mediating the binding affinity and specificity. Interestingly, the open conformation of the EphA4 LBD is slightly unstable in the absence of it natural ligand ephrins, implying that the conformational transition from the closed to open has to be driven by the high

  20. The Deadliest Catch: Reeling In Big Phish With a Deep MD5 Net

    Directory of Open Access Journals (Sweden)

    Brad Wardman

    2010-09-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Because phishing continues to grow in prevalence resulting from new exploits and attack vectors, the traditional response using takedowns and blacklists does not seem to impede phishers.  A handful of law enforcement projects — such as the FBI's Digital PhishNet or the Internet Crime and Complaint Center (ic3.gov — have shown an ability to collect phishing data, but these collections have not resulted in a significant decline in criminal phishing activity.In this paper, a new system is demonstrated for prioritizing investigative resources. One way of correlating two phishing websites is by proving they were created by the same kit.  These kits contain the content files needed to create the counterfeit website as well as the email addresses and aliases of the web site creators.  This research provides a new method for correlating phishing evidence through the collection of phishing kits and a Deep MD5 Matching clustering algorithm. The correlation provides law enforcement with a means of prioritizing the allocation of limited investigative resources by identifying frequently repeating offenders.

  1. Bruce X Longwood television reception survey

    International Nuclear Information System (INIS)

    Property owners living close to a proposed 500-kV transmission line route in Ontario expressed concerns that the line would affect their television reception. To give a reasonable evaluation of the impact of the transmission line, tests were conducted before and after installation of the line in which the possibility of active or passive interference to reception was assessed. Measurements were made of signal strength and ambient noise, and television reception was also recorded on videotape. Possible transmission line effects due to radiated noise, signal reduction, and ghosts are analyzed. The analysis of signal and noise conditions, and the assessment of videotaped reception, provide reasonable evidence that the line has had negligible impact on the television reception along the line route. 13 refs., 18 figs., 12 tabs

  2. Neighborhoods, Boundaries for the neighborhoods of the City of Baltimore, MD., Published in 2010, 1:2400 (1in=200ft) scale, City of Baltimore.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Neighborhoods dataset, published at 1:2400 (1in=200ft) scale as of 2010. It is described as 'Boundaries for the neighborhoods of the City of Baltimore, MD.'....

  3. Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet): Case Definition in Surveillance for Childhood-Onset Duchenne/Becker Muscular Dystrophy

    OpenAIRE

    Mathews, Katherine D.; Cunniff, Chris; Kantamneni, Jiji R.; Ciafaloni, Emma; Miller, Timothy; Matthews, Dennis; Cwik, Valerie; Druschel, Charlotte; Miller, Lisa; Meaney, F. John; Sladky, John; Romitti, Paul A.

    2010-01-01

    The Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet) is a multisite collaboration to determine the prevalence of childhood-onset Duchenne/Becker muscular dystrophy and to characterize health care and health outcomes in this population. MD STARnet uses medical record abstraction to identify patients with Duchenne/Becker muscular dystrophy born January 1, 1982 or later who resided in one of the participating sites. Critical diagnostic elements of each abstracted record...

  4. Determination of mendelevium (1+) ionic radius and MdCl solubility on the basis of its isomorphous cocrystallization with NaCl and KCl

    International Nuclear Information System (INIS)

    On the basis of previously obtained exlperimental data on coefficients of cocrystallization of microamounts of MdCl with NaCl and KCl in water-ethanol solutions the calculation of ionic radius of mendelevium (1+) are made. It turned out that for coordination number 6 value Rsub(Mdsup(+))=0.117 nm, which agrees with theoretically calculated value. Solubility and product of MdCl activity in water-ethanol solutions of different compositions at 25 deg are calculated

  5. MD5算法在高校媒体资产管理系统中的应用研究%Study of MD5 Algorithm in the System of Colleges and Universities'Media Asset Management

    Institute of Scientific and Technical Information of China (English)

    贾鹏程; 宋燕燕; 李绍彬; 王莉莉

    2009-01-01

    主要研究利用MD5算法的加密及文件校验功能,实现高校媒资系统中系统安全性管理、文件重复性校验、文件审查、明确责任等方面的应用,以达到优化高校媒体资产管理系统,提高其安全性及可用性.

  6. 一种基于MD5值的数字图像加密新算法%A NEW ENCRYPTION ALGORITHM FOR DIGITAL IMAGES BASED ON MD5 VALUE

    Institute of Scientific and Technical Information of China (English)

    葛锦环; 李际军

    2010-01-01

    数字图像在远距离传输时必须保证其完整性和安全性.采用数字图像本身的MD5值作为位加密周期序列,设计了一种简单、高效而且实用的图像加密算法.该算法针对数字图像的应用特点,既实现了图像完整性的验证功能又解决了图像安全性的问题.

  7. SOFTWARE IMPLEMENTATION OF DYNAMIC PASSWORD TECHNOLOGY BASED ON MD5 ALGORITHM%基于MD5算法的动态口令技术的软件实现

    Institute of Scientific and Technical Information of China (English)

    叶晰; 叶依如

    2009-01-01

    描述动态口令技术的基本原理,研究一种基于MD5加密算法的动态口令技术的软件实现方法,并通过实例演示了该方法的实际效果.对于开发各类电子商务网站的动态口令技术可以提供一定的帮助.

  8. Immunological Changes of Chicks Immunized with Marek‘s Disease Vaccines and Challenged with Virulent MD Virus

    Institute of Scientific and Technical Information of China (English)

    LiuZhonggui; GaoRong; 等

    1995-01-01

    The experiment was conducted to inoculate one-day old chicks with Marek's disecae(MD) trivalent and herpesvirus of turkey(HVT) vaccines separately,and then to challenge them with virulent MD virus(vMDV) at the age of 15 days,and 5,25,45,and 75 days after the challenge with vMDV,comparing with the cotrol-challenged chicks without immunization,to detect the immunoprotetive efficacy and dynamic changes of the inductive activity of interleukin-2(IL-2),expression of IL-2 receptor and proliferative function of T cells in thymus and spleen;the number of ANAET,APT,cells and IgG,IgM,IgA antibody-producing cells in Bursa Fabricius,spleen,thymus,cecal tonsil and Harder gland;as the amount of T cells and IgG,IgA in peripheral blood as well as the content of IgG,IgM and IgA in the tear,trachea washings,bile and intestinal fluids of the experimental chicks.The experimental results firstly demonstrate that the immunoregulation of IL-2,and IL-2 receptor,the cellualr and humoral immune resposes were significantly enhanced in the central and peripheral immune organs;the local mucosal immune funcsignificantly enhanced in the central and peripheral immune organs;the local mucosal immune function were markedly amplified in the respiratory and digestive tracts of the immunized-challenged,chicks,which were closely correlated with the immunoprotection against MD;the immune response and immunoprotective effect of the trivalent vaccine-immunized chicks wrer much better than those of HVT vaccine-immunized chicks.

  9. A novel M-D (multi-dimensional) linear prediction filter approach for hourly solar radiation forecasting

    International Nuclear Information System (INIS)

    2-D linear prediction filter approach is a well-known method in the literature. Such an approach that uses past samples to predict present values is also applicable to solar irradiance data. Therefore, such models have limited accuracy levels. In this study, a new approach for hourly solar radiation forecasting is developed. First, the data measured hourly throughout a year, i.e., ambient temperature and extraterrestrial irradiance are converted into 2-D image forms. Then, the data points are evaluated as pixels of the images. Next, different M-D (Multi-Dimensional) linear prediction filter models are designed. The novelty of these models is that they utilize not only the solar irradiance image but also different images that correlate with solar irradiance data. These filters are employed both to link the images with each other and to predict solar irradiance data. It is shown that, to incorporate the temperature, extraterrestrial irradiance and the derivatives of these data with proposed M-D linear prediction filters, it is possible to improve the prediction accuracy. The results are compared with previously developed linear prediction filter models and conventional methods. Experimental results illustrates that proposed approach gives better prediction accuracies at a range 1%–30% for different M-D models compared with 2-D ones. - Highlights: • A new technique is proposed for solar radiation forecasting. • Present, past and future values of extraterrestrial calculations are incorporated. • First order derivative of parameters such as extraterrestrial is employed. • Multi-Dimensional filters are used to link the image versions of the data. • %3–40 improvement on prediction is achieved for different filter templates

  10. The Influences of Wushu TV Series" the Legend of Bruce Lee" on Young Wushu Learners%武侠电视连续剧《李小龙传奇》对青少年武术学习者的影响

    Institute of Scientific and Technical Information of China (English)

    段君涛; 梅杭强; 彭婵

    2012-01-01

    The success of the "Legend of Bruce Lee" raised a strong response in the community and great impact,especially on young Wushu learners. With the methods of literature, expert interviews, logical analysis and other methods, the paper sorts out and analyzes the impact of the TV program on young Wushu learners. Then the study concludes: "Legend of Bruce Lee" has great role for Junior Wushu learners to further carry forward the national spirit and inspire a sense of patriotism and promoting youth Wushu learners to choose the correct ways, resulting in a substantial positive impact, "legend of Bruce Lee" unique image of the masters promote youth Wushu learners to develop healthy personality, manifested by the Bruce Lee's own hard work and deligence on young Wushu learners in the process of learning Wushu, they have a lot of incentives. Bruce Lee promotes Wushu learners abide by social morality, keep law and do a loyalty gentleman.%《李小龙传奇》的成功播出在社会上产生了强烈的反响,尤其是对青少年武术学习者产生了很大的影响。文章运用文献资料法、专家访谈法、逻辑分析法等研究方法对这部电视剧给青少年武术学习者所带来的影响进行梳理和分析。并得出结论:《李小龙传奇》对青少年武术学习者进一步弘扬民族精神和激发爱国主义意识起到了很大的促进作用;对青少年武术学习者在选择正确的学习方法方面提供了很多的借鉴作用,产生了很大的积极影响;《李小龙传奇》里独特的主人翁形象促进了青少年武术学习者形成健全的人格;李小龙自身表现出来的勤奋和坚韧对青少年武术学习者产生了很重要的影响,对他们在学习武术的过程中产生了很大的激励作用,李小龙还促使武术学习者遵守社会道德、遵纪守法做一个忠义之士.

  11. Roles of Ⅴ/Ⅲ ratio and mixture degree in GaN growth: CFD and MD simulation study

    Institute of Scientific and Technical Information of China (English)

    Zhou An; Xiu Xiang-Qian; Zhang Rong; Xie Zi-Li; Hua Xue-Mei; Liu Bin; Han Ping

    2013-01-01

    To understand the mechanism of Gallium nitride (GaN) film growth is of great importance for their potential applications.In this paper,we investigate the growth behavior of the GaN film by combining computational fluid dynamics (CFD) and molecular dynamics (MD) simulations.Both of the simulations show that Ⅴ/Ⅲ mixture degree can have important impacts on the deposition behavior,and it is found that the more uniform the mixture is,the better the growth is.Besides,by using MD simulations,we illustrate the whole process of the GaN growth.Furthermore,we also find that the Ⅴ/Ⅲ ratio can affect the final roughness of the GaN film.When the Ⅴ/Ⅲ ratio is high,the surface of final GaN film is smooth.The present study provides insights into GaN growth from the macroscopic and microscopic views,which may provide some suggestions on better experimental GaN preparation.

  12. Microscopic dynamical description of proton-induced fission with the Constrained Molecular Dynamics (CoMD) Model

    CERN Document Server

    Vonta, N; Veselsky, M; Bonasera, A

    2015-01-01

    The microscopic description of nuclear fission still remains a topic of intense basic research. Un- derstanding nuclear fission, apart from a theoretical point of view, is of practical importance for energy production and the transmutation of nuclear waste. In nuclear astrophysics, fission sets the upper limit to the nucleosynthesis of heavy elements via the r-process. In this work we initiated a systematic study of intermediate energy proton-induced fission using the Constrained Molecu- lar Dynamics (CoMD) code. The CoMD code implements an effective interaction with a nuclear matter compressibility of K=200 (soft EOS) with several forms of the density dependence of the nucleon-nucleon symmetry potential. Moreover, a constraint is imposed in the phase-space occu- pation for each nucleon restoring the Pauli principle at each time step of the collision. A proper choice of the surface parameter of the effective interaction has been made to describe fission. In this work, we present results of fission calculation...

  13. Estimation of Ecloud and TMCI Driven Vertical Instability Dynamics from SPS MD Measurements - Implications for Feedback Control

    CERN Document Server

    Turgut, O; Fox, J D; Ndabashimiye, G; Rivetta, C H; Swiatlowski, M; Höfle, W; Salvant, B; Secondo, R

    2011-01-01

    We present analysis of beam motion data obtained in high intensity SPS MD studies in 2009 and 2010. The single-bunch vertical E-cloud motion seen in parts of the bunch train after injection shows large tune shifts (roughly 0.02 above the 0.185 tune) developing between tail and head of unstable bunches. The unstable vertical motion has spectral content up to roughly 1.2 GHz and a quasi-periodic growth and decoherence relaxation oscillation effect is seen with time scales of hundred turns. Beam slice FFT and RMS techniques are illustrated to extract parameters important for the design of wide-band vertical feedback system, such as a growth rates of unstable motion, tune shifts within a single bunch and characterization of the bandwidth of the unstable structures within a bunch. We highlight the impact of synchrotron motion and injection transients on a proposed vertical processing channel. We present our MD plans including the beam driving process, developments in reduced model / identification techniques to ex...

  14. R2E-related MD: slow controlled losses for RadMon/BLM cross-checks

    CERN Document Server

    Calviani, M; Spiezia, G; Sapinski, M; Priebe, A; Nordt, A; Pojer, M; CERN. Geneva. ATS Department

    2011-01-01

    The purpose of the dedicated R2E MD has been to evaluate the R factor (i.e. the ratio between the thermal neutron fluence and the high energy hadron fluence (>20MeV) for various tunnel locations, to measure the HEH radiation level gradient along the MBC dipole and on the MQ, to check the ratio the BLM measured dose and RadMon SEU counts and to study the dose gradient between the standard BLM beam axis location and at the level of the equipment location. Within the R2E Mitigation Project, these accurate measurement and cross-check of the mentioned parameters are of great importance for the evaluation and interpretation of the R2E-related radiation levels, as well as for the evaluation of the failure cross-section of specific equipment (i.e. QPS ISO150). In addition, a short part of the MD has been devoted to the comparison of BLM signals generated by loss directed inwards and outwards with respect to the LHC ring.

  15. Investigation of laser shock induced ductile damage at ultra-high strain rate by using large scale MD simulations

    Science.gov (United States)

    Cuq-Lelandais, Jean-Paul; Boustie, Michel; Soulard, Laurent; Berthe, Laurent; Bontaz-Carion, Joelle; de Resseguier, Thibaut

    2012-03-01

    Laser driven shocks allow an investigation of materials behavior at very high strain rate (107s-1) and present a great interest for research applications. Microscopic simulations of ultra-short laser driven shock on micrometric Tantalum single-crystals have been performed by using the CEADAM Classical Molecular Dynamics code. This method, complementary to continuum models, provides an analysis the microscopic processes related to damage (ductile pore nucleation and growth) which occurs during spallation. These results are compared to spallation experimental data (VISAR signals, micro-tomography) obtained with the LULI100TW femtosecond laser in order to validate the MD behavior. Moreover, in the framework of a multi-scale approach, we show the possibility to use MD simulation to fit macroscopic damage models. This method is illustrated with an application to the parameters determination of Kanel damage model parameters. This also shows the high strain rates involved during damage process, around 109s-1, can approach the inter-atomic theoretical cohesion stress threshold.

  16. Molecular cloning and functional analysis of a UV-B photoreceptor gene, MdUVR8 (UV Resistance Locus 8), from apple.

    Science.gov (United States)

    Zhao, Cheng; Mao, Ke; You, Chun-Xiang; Zhao, Xian-Yan; Wang, Shu-Hui; Li, Yuan-Yuan; Hao, Yu-Jin

    2016-06-01

    UVR8 (UV Resistance Locus 8) is an ultraviolet-B (UV-B; 280-315nm) light receptor that is involved in regulating many aspects of plant growth and development. UV-B irradiation can increase the development of flower and fruit coloration in many fruit trees, such as grape, pear and apple. Previous investigations of the structure and functions of UVR8 in plants have largely focused on Arabidopsis. Here, we isolated the UVR8 gene from apple (Malus domestica) and analyzed its function in transgenic Arabidopsis. Genomic and protein sequence analysis showed that MdUVR8 shares high similarity with the AtUVR8 protein from Arabidopsis, including the conserved seven-bladed β-propeller, the C27 region, the 3 "GWRHT" motifs and crucial amino-acid residues (14 Trps, 2 Args). A point mutation prediction and three-dimensional structural analysis of MdUVR8 indicated that it has a similar structure to AtUVR8 and that the crucial residues are also important in MdUVR8. In terms of transcript levels, MdUVR8 expression was up-regulated by UV-B light, which suggests that its expression follows a 24-h circadian rhythm. Using heterologous expression of MdUVR8 in both uvr8-1 mutant and wild-type (WT) Arabidopsis, we found that MdUVR8 regulates hypocotyl elongation and gene expression under UV-B light. These data provide functional evidence for a role of MdUVR8 in controlling photomorphogenesis under UV-B light and indicate that the function of UVR8 is conserved between Arabidopsis and apple. Furthermore, we examined the interaction between MdUVR8 and MdCOP1 (constitutive photomorphogenic1) using a yeast two-hybrid assay and a co-immunoprecipitation assay. This interaction provides a direction for investigating the regulatory mechanisms of the UV-B-light pathway in apple. PMID:27095405

  17. Exploring Beta-Amyloid Protein Transmembrane Insertion Behavior and Residue-Specific Lipid Interactions in Lipid Bilayers Using Multiscale MD Simulations

    Science.gov (United States)

    Qiu, Liming; Vaughn, Mark; Cheng, Kelvin

    2013-03-01

    Beta-amyloid (Abeta) interactions with neurons are linked to Alzheimer's. Using a multiscale MD simulation strategy that combines the high efficiency of phase space sampling of coarse-grained MD (CGD) and the high spatial resolution of Atomistic MD (AMD) simulations, we studied the Abeta insertion dynamics in cholesterol-enriched and -depleted lipid bilayers that mimic the neuronal membranes domains. Forward (AMD-CGD) and reverse (CGD-AMD) mappings were used. At the atomistic level, cholesterol promoted insertion of Abeta with high (folded) or low (unfolded) helical contents of the lipid insertion domain (Lys28-Ala42), and the insertions were stabilized by the Lys28 snorkeling and Ala42-anchoring to the polar lipid groups of the bilayer up to 200ns. After the forward mapping, the folded inserted state switched to a new extended inserted state with the Lys28 descended to the middle of the bilayer while the unfolded inserted state migrated to the membrane surface up to 4000ns. The two new states remained stable for 200ns at the atomistic scale after the reverse mapping. Our results suggested that different Abeta membrane-orientation states separated by free energy barriers can be explored by the multiscale MD more effectively than by Atomistic MD simulations alone. NIH RC1-GM090897-02

  18. Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-κB pathway with anti-inflammatory properties.

    Science.gov (United States)

    Liu, Dandan; Cao, Gang; Han, Likai; Ye, Yilu; SiMa, Yuhan; Ge, Weihong

    2016-08-01

    Radix Tetrastigmae (RT) has immunomodulatory activity, particularly on inflammation and the flavonoids from RT (RTFs) are one of the main components. In this study, we detected the anti-inflammation potential of RTFs in LPS-induced RAW264.7 cells and tried to uncover the underlying mechanism. Results demonstrated that RTFs (10-160μg/ml) treatment significantly decreased LPS-induced production of pro-inflammatory mediators, including NO, IL-1β, TNF-α, IL-6, IL-12p40, sTNF-R1 and increased anti-inflammatory cytokine IL-10 expression in macrophages in a dose-dependent manner. Molecular research showed the up-regulated expression of TLR4, MD-2, MyD88 and TLR4/MD-2 complex induced by LPS were attenuated after RTFs treatment. Furthermore, phosphorylation and activity of JNK and NF-κB, two important downstream signaling molecules of TLR4/MD-2 pathway, were also changed along with TLR4/MD-2 complex. But no significant phosphorylation was observed on p38 and ERK. In conclusion, RTFs contribute to the regulation of LPS-induced inflammatory response in RAW264.7 cells through TLR4/MD-2 mediated NF-κB and JNK pathway. It may be a potential choice for the treatment of inflammation diseases. PMID:27235587

  19. Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia.

    Science.gov (United States)

    Di Lorenzo, Flaviana; Kubik, Łukasz; Oblak, Alja; Lorè, Nicola Ivan; Cigana, Cristina; Lanzetta, Rosa; Parrilli, Michelangelo; Hamad, Mohamad A; De Soyza, Anthony; Silipo, Alba; Jerala, Roman; Bragonzi, Alessandra; Valvano, Miguel A; Martín-Santamaría, Sonsoles; Molinaro, Antonio

    2015-08-28

    Lung infection by Burkholderia species, in particular Burkholderia cenocepacia, accelerates tissue damage and increases post-lung transplant mortality in cystic fibrosis patients. Host-microbe interplay largely depends on interactions between pathogen-specific molecules and innate immune receptors such as Toll-like receptor 4 (TLR4), which recognizes the lipid A moiety of the bacterial lipopolysaccharide (LPS). The human TLR4·myeloid differentiation factor 2 (MD-2) LPS receptor complex is strongly activated by hexa-acylated lipid A and poorly activated by underacylated lipid A. Here, we report that B. cenocepacia LPS strongly activates human TLR4·MD-2 despite its lipid A having only five acyl chains. Furthermore, we show that aminoarabinose residues in lipid A contribute to TLR4-lipid A interactions, and experiments in a mouse model of LPS-induced endotoxic shock confirmed the proinflammatory potential of B. cenocepacia penta-acylated lipid A. Molecular modeling combined with mutagenesis of TLR4-MD-2 interactive surfaces suggests that longer acyl chains and the aminoarabinose residues in the B. cenocepacia lipid A allow exposure of the fifth acyl chain on the surface of MD-2 enabling interactions with TLR4 and its dimerization. Our results provide a molecular model for activation of the human TLR4·MD-2 complex by penta-acylated lipid A explaining the ability of hypoacylated B. cenocepacia LPS to promote proinflammatory responses associated with the severe pathogenicity of this opportunistic bacterium. PMID:26160169

  20. 基于MD5算法的动态双因子安全认证技术在企业ERP系统中的应用%Dynamic state based on MD5 algorithm in enterprise ERP system

    Institute of Scientific and Technical Information of China (English)

    岳建斌

    2010-01-01

    针对现有企业ERP系统采用用户单一静态口令安全机制所存在的安全漏洞问题,提出了一个基于MD5算法以及短信息动态口令+用户静态口令的双因子安全认证方法,并讨论了实现.该方法无须改变现有系统架构,可有效验证用户身份的合法性.弥补了传统单因子认证方法的很多弊端.

  1. Design and Research of Web Pages Detection Algorithms Based on MD5%基于MD5的网页去重算法的设计与研究

    Institute of Scientific and Technical Information of China (English)

    闫俊伢

    2013-01-01

    随着互联网的发展及网络信息的指数状增长,网络上出现了大量的重复网页,降低了检索的查全率和查准率,影响了检索效率.因此,网页去重的准确度直接影响着搜索引擎的质量.本文通过对结构化文本的描述,提出了一种基于MD5的改进的网页去重算法,并从算法内容、算法特征、算法设计进行了阐述,实验表明该方法对提高查全率和查准率具有很好的效果.

  2. Analysis and Realization of Data Coverage Scheme based on md5 Algorithm%基于md5算法的数据覆盖方法分析与实现

    Institute of Scientific and Technical Information of China (English)

    张孟资; 谢宝陵

    2011-01-01

    分析比较了数据覆盖技术在敏感数据保护方面的应用,阐述了数据覆盖技术的发展现状.结合现代磁盘编码技术的发展,提出了用md5算法来产生覆盖序列的一种数据覆盖方案.针对Windows FAT32文件结构介绍了一个数据覆盖系统设计的主要技术,并实现了数据恢复与擦除系统,验证了该数据覆盖方案的可行性.

  3. Research And Implement of Message-Digest Algorithm 5%MD5报文摘要算法的研究与实现

    Institute of Scientific and Technical Information of China (English)

    袁薇

    2009-01-01

    在信息加密中,采用报文摘要的方法不但可以节省加密时问,还可以节省报文传输和存储的开销.在目前提出多种报文摘要中,应用最广的就是MD5.本文针对MD5报文摘要算法进行了深入研究,分析了算法的安全性,通过程序开发对算法进行了实现,总结了MD5加密算法的应用.

  4. A Modification of Gamma Surveymeter Dosemeter 3007A for Monitoring Use Ethernet by PLC T100MD Series

    International Nuclear Information System (INIS)

    It has been modified a gamma surveymeter Dosemeter 3007A. The Surveymeter represents analogous surveymeter, so that an interface for data acquisition is required. Acquisition system from surveymeter is added to the voltage amplifier module from 0 - 200 mV to 0 - 5 V. This voltage value will represent of doses 0 - 5 mR/hour. Hereinafter the analogous signal 0 - 5 V as signal of input to peripheral of PLC T100MD series. Data in the form of processed analogous signal presented at local display of PLC. For long distance monitoring, data have been sent to a computer from PLC by ethernet. After this modification, the surveymeter can be used to monitor from long distance. By using Internet Service Provider, monitoring can be done at any time and any where as long as network internet is available. (author)

  5. Lignée de Canola MON88302 TruFlexMC Roundup ReadyMD

    OpenAIRE

    Canada, Publié par la Direction des aliments de Santé

    2014-01-01

    Santé Canada a avisé Monsanto Canada Inc. qu’il ne s’oppose pas à la vente d’aliments dérivés du canola MON88302 (canola TruFlexMC Roundup ReadyMD). Le Ministère a réalisé une évaluation approfondie de cette lignée de canola conformément à ses Lignes directrices sur l’évaluation de l’innocuité des aliments nouveaux. Ces lignes directrices sont fondées sur des principes admis internationalement pour l’établissement de l’innocuité des aliments à caractères nouveaux. L...

  6. Effects of Fatty Acids on Low-Sulfur Diesel Lubricity:Experimental Investigation, DFT Calculation and MD Simulation

    Institute of Scientific and Technical Information of China (English)

    Luo Hui; Fan Weiyu; Li Yang; Zhao Pinhui; Nan Guozhi

    2013-01-01

    The continuous reduction in sulfur content of fuels would lead to diesel fuel with poor lubricity which could re-sult in engine pump failure. In the present work, fatty acids were adopted as lubricity additives to low-sulfur diesel fuel. It was attempted to correlate the molecular structures of fatty acids, such as carbon chain length, degree of saturation and hy-droxylation, to their lubricity enhancement, which was evaluated by the High-Frequency Reciprocating Rig (HFRR) meth-od. The efifciency order was supported by the density functional theory (DFT) calculations and the molecular dynamics (MD) simulations. The lubricity enhancing properties of fatty acids are mainly determined by the cohesive energy of adsorbed iflms formed on iron surface. The greater the cohesive energy, the more efifciently the fatty acid would enhance the lubricity of low-sulfur diesel fuel.

  7. Monomerization alters the dynamics of the lid region in Campylobacter jejuni CstII: an MD simulation study.

    Science.gov (United States)

    Prabhakar, Pradeep Kumar; Srivastava, Alka; Rao, K Krishnamurthy; Balaji, Petety V

    2016-04-01

    CstII, a bifunctional (α2,3/8) sialyltransferase from Campylobacter jejuni, is a homotetramer. It has been reported that mutation of the interface residues Phe121 (F121D) or Tyr125 (Y125Q) leads to monomerization and partial loss of enzyme activity, without any change in the secondary or tertiary structures. MD simulations of both tetramer and monomer, with and without bound donor substrate, were performed for the two mutants and WT to understand the reasons for partial loss of activity due to monomerization since the active site is located within each monomer. RMSF values were found to correlate with the crystallographic B-factor values indicating that the simulations are able to capture the flexibility of the molecule effectively. There were no gross changes in either the secondary or tertiary structure of the proteins during MD simulations. However, interface is destabilized by the mutations, and more importantly the flexibility of the lid region (Gly152-Lys190) is affected. The lid region accesses three major conformations named as open, intermediate, and closed conformations. In both Y121Q and F121D mutants, the closed conformation is accessed predominantly. In this conformation, the catalytic base His188 is also displaced. Normal mode analysis also revealed differences in the lid movement in tetramer and monomer. This provides a possible explanation for the partial loss of enzyme activity in both interface mutants. The lid region controls the traffic of substrates and products in and out of the active site, and the dynamics of this region is regulated by tetramerization. Thus, this study provides valuable insights into the role of loop dynamics in enzyme activity of CstII. PMID:26208676

  8. A standard case of subtitling. : A comparative analysis of the subtitling of Scrubs and House M.D. with a focus on medical terminology.

    OpenAIRE

    Lindell, Klara

    2010-01-01

    Toury’s first law of translation states that translation of all kinds entails standardisation and, moreover, that the more peripheral the status of a text is, the more standardised its translation will be. As such, the purpose of this essay was to investigate to what extent this holds true in the Swedish translations of the two US television hospital shows Scrubs and House M.D. Though they are both hospital shows, House M.D. – considering its unprecedented genre hybridity and unusual plot str...

  9. The Information Content of Note Disclosures and MD&A Information in the Financial Report – A Study of Market Reactions in Denmark

    DEFF Research Database (Denmark)

    Thinggaard, Frank; Sønderby Jeppesen, Carsten; Madsen, Kasper

    2015-01-01

    The preparation of disclosures in the financial report constitutes a significant cost to most companies, but do the disclosures have information content to investors? This paper examines stock market reactions to the release of note disclosures and MD&A (management discussion and analysis......) information. The study is based on data from the Danish capital market in 2006-2009 because here it is largely possible to isolate the release of such information from other information in the financial report. The primary results suggest that for some companies, note disclosures and information in the MD...

  10. Advanced meet-in-the-middle preimage attacks: First results on full tiger, and improved results on MD4 and SHA-2

    DEFF Research Database (Denmark)

    Guo, Jian; Ling, San; Wang, Huaxiong; Rechberger, Christian

    2010-01-01

    We revisit narrow-pipe designs that are in practical use, and their security against preimage attacks. Our results are the best known preimage attacks on Tiger, MD4, and reduced SHA-2, with the result on Tiger being the first cryptanalytic shortcut attack on the full hash function. Our attacks runs...... in time 2188.8 for finding preimages, and 2188.2 for second-preimages. Both have memory requirement of order 28, which is much less than in any other recent preimage attacks on reduced Tiger. Using pre-computation techniques, the time complexity for finding a new preimage or second-preimage for MD4...

  11. Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4/MD2 and MyD88 During Bacterial Infection In Vivo

    OpenAIRE

    Zhang, Jin-Ping; Yang, Yi(Department of Electrophysics, National Chiao-Tung University, Hsinchu, Taiwan, ROC); Levy, Ofer; Chen, Chao

    2010-01-01

    Toll-like receptors (TLRs) play important roles in infection. We have previously reported TLR2 is up-regulated in neonatal Gram-positive (G+) bacteremia whereas TLR4 is up-regulated in neonatal Gram-negative (G−) bacteremia. For functional signaling, TLR4 requires MD-2 and both TLR2 and TLR4 signal need MyD88. However, it is unknown whether newborns can enhance expression of MD-2 and MyD88 with bacterial infection in coordination with TLR expression. We characterized neonatal peripheral blood...

  12. Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.

    Science.gov (United States)

    Martínez-Guitián, Marta; Vázquez-Ucha, Juan C; Odingo, Joshua; Parish, Tanya; Poza, Margarita; Waite, Richard D; Bou, German; Wareham, David W; Beceiro, Alejandro

    2016-07-01

    Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FICindex] = 0.13 to 0.24) and colistin-resistant strains with mutations in pmrB and phosphoethanolamine modification of lipid A (FICindex = 0.14 to 0.25) but not against colistin-resistant Δlpx strains with loss of lipopolysaccharide (FICindex = 0.75 to 1). A colistin/MD3 combination would need to be targeted to strains with specific colistin resistance mechanisms. PMID:27139471

  13. Evaluation of the ability of two multiplex PCR assays (Bruce-ladder and Suis-ladder) to distinguish six Brucella species and Brucella suis at the biovar level%应用多重PCR鉴别布鲁氏菌种及猪种5个生物型研究

    Institute of Scientific and Technical Information of China (English)

    陈军; 崔步云; 赵鸿雁; 朴东日; 姜海; 邰新平; 田国忠

    2013-01-01

    Objective To evaluate the ability of two types of multiplex PCR assays (Bruce-ladder and Suis-ladder) to distinguish six Brucella species and five biovars of Brucella suis. Methods A Bruce-ladder multiplex PCR assay was performed using 8 pairs of primers to distinguish six Brucella species. A Suis-ladder multiplex PCR assay was performed using 4 pairs of primers to distinguish five biovars of B. suis. The tested strains, which consisted of 27 reference strains of six Brucella species and 239 Brucella isolates, were examined using PCR assays and methods of biological identification. Results The Bruce-ladder multiplex PCR assay differentiated six Brucella species, including Brucella abortus, Brucella melitensis , Brucella suis , Brucella canis , Brucella ovis , and Brucella neotomae , in a single step. The Suis-ladder multiplex PCR assay differentiated five biovars of B. suis in a single step. The electrophoresis patterns of the vaccine strain S2 and biovar 1 of B. suis were identical. The total rate of concordance between methods of biological identification and multiplex PCR assays was 100%. Conclusion The Bruce-ladder and Suis-ladder multiplex PCR assays are rapid and specific methods of respectively identifying Brucella species and B. suis at the biovar level.%目的 应用布鲁氏菌种多重PCR和猪种多重PCR对布鲁氏菌进行鉴定. 方法 对两套多重PCR方法进行条件优化,应用布鲁氏菌参考菌株、疫苗株和临床分离菌株进行评价,并与生物学分型方法进行比较. 结果 布鲁氏菌种多重PCR扩增(包括牛种布鲁氏菌8个生物型,猪种5个生物型,羊种3个生物型,以及绵羊附睾、犬和沙漠森林野鼠种各1个生物型)可获得152~1 682 bp的8个DNA片段,但种间DNA片段数不一.猪种多重PCR扩增猪种5个生物型菌株得到197~774 bp的7个DNA片段,不同生物型的DNA扩增图谱不同;猪种疫苗株S2扩增图谱与猪种生物1型相同,多重PCR分型方法与生物学

  14. MD300测深系统在河道地形测绘中的应用%Application of MD300 sounding system to the topographic mapping of river channels

    Institute of Scientific and Technical Information of China (English)

    肖华; 唐从胜; 田次平

    2001-01-01

    In recent years,the global positioning system(GPS) technique is rapidly developing,since it is characterized by continuity,real-time,all-weather operation with high accuracy,this technique has found extensive application in survey,positioning,navigation.MD300 sounding system is a new topograpbic survey system especially for water areas supported by GPS.In combination with the development and application of the sounding system carried out by the Jingjiang Investigation Bureau of Hydrology and Water Resources of Changjiang Water Resources Commission,the structural function and system configuration and the implementation methods of the system are presented.From the viewpoint of its practical effect of application,this sounding system has characteristics of accurate positioning,accurate water depth acquisition and high automation procedure,compared with conventional metheds.The system is an ideal river channel mapping system.%近年来,全球定位系统(GPS)技术迅猛发展,由于它具有连续、实时、高精度、全天候的特点,使其在诸如测量、定位、导航中得到广泛应用。MD300测深系统是在GPS支持下的一种全新的水域地形测量系统。结合长江委荆江水文水资源局对该系统的开发、应用,介绍了其结构功能、系统配置及实现方法,从实际运用效果看,与常规测量方法相比,该系统具有定位精确、水深采集准确、自动化程度高等特点,是理想的河道测绘系统。

  15. Muscavirus (MdHV) disease dynamics in house fly populations – how is this virus transmitted and has it potential as a biological control agent?

    Science.gov (United States)

    The newly classified family Hytrosaviridae comprises several double-stranded DNA viruses that have been isolated from various dipteran species. These viruses cause characteristic salivary gland hypertrophy and suppress gonad development in their hosts. One member, Muscavirus or MdHV, exclusively in...

  16. Preliminary comparison of the Essie and PubMed search engines for answering clinical questions using MD on Tap, a PDA-based program for accessing biomedical literature.

    Science.gov (United States)

    Sutton, Victoria R; Hauser, Susan E

    2005-01-01

    MD on Tap, a PDA application that searches and retrieves biomedical literature, is specifically designed for use by mobile healthcare professionals. With the goal of improving the usability of the application, a preliminary comparison was made of two search engines (PubMed and Essie) to determine which provided most efficient path to the desired clinically-relevant information. PMID:16779415

  17. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations

    Energy Technology Data Exchange (ETDEWEB)

    Vener, M. V., E-mail: mikhail.vener@gmail.com [Mendeleev University of Chemical Technology, Moscow (Russian Federation); Odinokov, A. V. [Photochemistry Center of the Russian Academy of Sciences, Moscow (Russian Federation); Wehmeyer, C. [Free University, Berlin (Germany); Sebastiani, D. [Martin-Luther-Universität Halle-Wittenberg, Halle (Germany)

    2015-06-07

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)–glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898–915 (2011)]. These structures are stabilized by the short {sup +}N–H⋯O{sup −} bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm{sup −1}. It is caused by the asymmetric stretching vibrations of the {sup +}N–H⋯O{sup −} fragment. Result of the present paper suggests that infrared spectroscopy in the 2000–2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is

  18. The structure and IR signatures of the arginine-glutamate salt bridge. Insights from the classical MD simulations

    International Nuclear Information System (INIS)

    Salt bridges and ionic interactions play an important role in protein stability, protein-protein interactions, and protein folding. Here, we provide the classical MD simulations of the structure and IR signatures of the arginine (Arg)–glutamate (Glu) salt bridge. The Arg-Glu model is based on the infinite polyalanine antiparallel two-stranded β-sheet structure. The 1 μs NPT simulations show that it preferably exists as a salt bridge (a contact ion pair). Bidentate (the end-on and side-on structures) and monodentate (the backside structure) configurations are localized [Donald et al., Proteins 79, 898–915 (2011)]. These structures are stabilized by the short +N–H⋯O− bonds. Their relative stability depends on a force field used in the MD simulations. The side-on structure is the most stable in terms of the OPLS-AA force field. If AMBER ff99SB-ILDN is used, the backside structure is the most stable. Compared with experimental data, simulations using the OPLS all-atom (OPLS-AA) force field describe the stability of the salt bridge structures quite realistically. It decreases in the following order: side-on > end-on > backside. The most stable side-on structure lives several nanoseconds. The less stable backside structure exists a few tenth of a nanosecond. Several short-living species (solvent shared, completely separately solvated ionic groups ion pairs, etc.) are also localized. Their lifetime is a few tens of picoseconds or less. Conformational flexibility of amino acids forming the salt bridge is investigated. The spectral signature of the Arg-Glu salt bridge is the IR-intensive band around 2200 cm−1. It is caused by the asymmetric stretching vibrations of the +N–H⋯O− fragment. Result of the present paper suggests that infrared spectroscopy in the 2000–2800 frequency region may be a rapid and quantitative method for the study of salt bridges in peptides and ionic interactions between proteins. This region is usually not considered in

  19. Serpins in fruit and vegetative tissues of apple (Malus domestica): expression of four serpins with distinct reactive centres and characterisation of a major inhibitory seed form, MdZ1b

    DEFF Research Database (Denmark)

    Hejgaard, Jørn; Laing, W.A.; Marttila, S.; Gleave, A.P.; Roberts, Thomas Hugh

    2005-01-01

    wide variety of tissues, including developing and mature fruits, seeds and vegetative buds as well as developing, mature and senescing leaves. Analysis of 46 sequences, most full-length, identified serpins with four distinct reactive centres belonging to two subfamilies (MdZ1 and MdZ2) with similar to...

  20. Theoretical investigation on the inclusion of TCDD with β-cyclodextrin by performing QM calculations and MD simulations

    International Nuclear Information System (INIS)

    Highlights: → We study the inclusion mechanism of TCDD with β-CD by theoretical methods. → Clearly, the formation of inclusion complex is an energetically driven process. → The inclusion complex can be detected by IR and Raman techniques. → The results imply that β-CD may be used as a host molecule to enrich TCDD molecules. - Abstract: The rapid enrichment and detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are currently challenging issues in the field of environmental science. In this paper, by performing quantum chemistry (QM) calculations and molecular dynamics (MD) simulations, we studied the inclusion complexation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a representative PCDD molecule, with β-cyclodextrin (β-CD), one of the widely used compounds in supramolecular chemistry. The calculated results reveal that the stable inclusion complex can be formed in both the gas phase and solvent, which proposes that β-CD may serve as a potential substrate enriching TCDD. The calculated vibrational spectra indicate that the infrared (IR) and Raman spectroscopy may be suitable for the detection of β-CD-modified TCDD. The present theoretical results may be informative to environmental scientists who are devoting themselves to developing effective methods for detection and treatment of POPs.

  1. Understanding self-assembly of charged-neutral block copolymer (BCP) and surfactant complexes using molecular dynamics (MD) simulation

    Science.gov (United States)

    Goswami, Monojoy; Sumpter, Bobby; Kilbey, Michael

    Here we report the formation of phase separated BCP-surfactant complexes resulting from the electrostatic self-assembly of charge-neutral block copolymers with oppositely charged surfactants. Complexation behaviors of oppositely charged polyelectrolytes has gained considerable attention in the field of soft condensed matter physics due to their potential application as functional nanomaterials for batteries, wastewater treatment and drug delivery systems. Numerous experiments have examined the self-assembled structures resulting from complexation of charge-neutral BCP and surfactants, however, there is a lack of comprehensive understanding at the fundamental level. To help bridge this gap, we use, MD simulations to study self-assembly and dynamics of the BCP-surfactant complex at the molecular level. Our results show an overcharging effect in BCPs with hydrophobic neutral blocks and a formation of core-shell colloidal structure. Hydrophilic neutral blocks, on the other hand, show stable, hairy colloidal structures with neutral blocks forming a loosely-bound, fuzzy outer layer. Our results qualitatively agree with previous SANS and SAXS experiments. This work was supported by the U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Materials Science and Engineering Division.

  2. Theoretical investigation on the inclusion of TCDD with {beta}-cyclodextrin by performing QM calculations and MD simulations

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Wenxiao [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China); Zhang, Dongju, E-mail: zhangdj@sdu.edu.cn [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China); Zhan, Jinhua [Key Lab of Colloid and Interface Chemistry, Ministry of Education, Institute of Theoretical Chemistry, Shandong University, Jinan 250100 (China)

    2011-09-15

    Highlights: {yields} We study the inclusion mechanism of TCDD with {beta}-CD by theoretical methods. {yields} Clearly, the formation of inclusion complex is an energetically driven process. {yields} The inclusion complex can be detected by IR and Raman techniques. {yields} The results imply that {beta}-CD may be used as a host molecule to enrich TCDD molecules. - Abstract: The rapid enrichment and detection of trace polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are currently challenging issues in the field of environmental science. In this paper, by performing quantum chemistry (QM) calculations and molecular dynamics (MD) simulations, we studied the inclusion complexation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a representative PCDD molecule, with {beta}-cyclodextrin ({beta}-CD), one of the widely used compounds in supramolecular chemistry. The calculated results reveal that the stable inclusion complex can be formed in both the gas phase and solvent, which proposes that {beta}-CD may serve as a potential substrate enriching TCDD. The calculated vibrational spectra indicate that the infrared (IR) and Raman spectroscopy may be suitable for the detection of {beta}-CD-modified TCDD. The present theoretical results may be informative to environmental scientists who are devoting themselves to developing effective methods for detection and treatment of POPs.

  3. MD modeling of screw dislocation influence upon initiation and mechanism of BCC-HCP polymorphous transition in iron

    Science.gov (United States)

    Dremov, V. V.; Ionov, G. V.; Sapozhnikov, F. A.; Smirnov, N. A.; Karavaev, A. V.; Vorobyova, M. A.; Ryzhkov, M. V.

    2015-09-01

    The present work is devoted to classical molecular dynamics investigation into microscopic mechanisms of the bcc-hcp transition in iron. The interatomic potential of EAM type used in the calculations was tested for the capability to reproduce ab initio data on energy evolution along the bcc-hcp transformation path (Burgers deformation + shuffe) and then used in the large-scale MD simulations. The large-scale simulations included constant volume deformation along the Burgers path to study the origin and nature of the plasticity, hydrostatic volume compression of defect free samples above the bcc to hcp transition threshold to observe the formation of new phase embryos, and the volume compression of samples containing screw dislocations to study the effect of the dislocations on the probability of the new phase critical embryo formation. The volume compression demonstrated high level of metastability. The transition starts at pressure much higher than the equilibrium one. Dislocations strongly affect the probability of the critical embryo formation and significantly reduce the onset pressure of transition. The dislocations affect also the resulting structure of the samples upon the transition. The formation of layered structure is typical for the samples containing the dislocations. The results of the simulations were compared with the in-situ experimental data on the mechanism of the bcc-hcp transition in iron.

  4. Verðmat fyrirtækja: Aðferðir og framkvæmd

    OpenAIRE

    Helga Lind Sigurbergsdóttir 1988

    2012-01-01

    Ritgerðin fjallar um verðmat fyrirtækja, aðferðir og framkvæmd. Í byrjun er útskýrt hver sé tilgangurinn með verðmati og hvers vegna fyrirtæki hafa áhuga á að framkvæma það. Helstu verðmatsaðferðir fyrirtækja verða svo kynntar til sögunnar og hverjir eru helstu árhrifaþættirnir við gerð verðmats. Farið yfir hvernig verðmat á sér stað hjá fyrirtækjum sem ekki eru skráð á skipulagðan verðbréfamarkað. Megináhersla ritgerðarinnar er þó á verðmat fyrirtækja sem eru skráð á skipulagðan verðbréfamar...

  5. Calibrating and Validating a Simulation Model to Identify Drivers of Urban Land Cover Change in the Baltimore, MD Metropolitan Region

    Directory of Open Access Journals (Sweden)

    Claire Jantz

    2014-09-01

    Full Text Available We build upon much of the accumulated knowledge of the widely used SLEUTH urban land change model and offer advances. First, we use SLEUTH’s exclusion/attraction layer to identify and test different urban land cover change drivers; second, we leverage SLEUTH’s self-modification capability to incorporate a demographic model; and third, we develop a validation procedure to quantify the influence of land cover change drivers and assess uncertainty. We found that, contrary to our a priori expectations, new development is not attracted to areas serviced by existing or planned water and sewer infrastructure. However, information about where population and employment growth is likely to occur did improve model performance. These findings point to the dominant role of centrifugal forces in post-industrial cities like Baltimore, MD. We successfully developed a demographic model that allowed us to constrain the SLEUTH model forecasts and address uncertainty related to the dynamic relationship between changes in population and employment and urban land use. Finally, we emphasize the importance of model validation. In this work the validation procedure played a key role in rigorously assessing the impacts of different exclusion/attraction layers and in assessing uncertainty related to population and employment forecasts.

  6. LDRD Final Report (08-ERD-037): Important Modes to Drive Protein MD Simulations to the Next Conformational Level

    Energy Technology Data Exchange (ETDEWEB)

    Sadigh, B

    2011-04-07

    Every action in biology is performed by dynamic proteins that convert between multiple states in order to engage their functions. Often binding to various ligands is essential for the rates of desired transitions to be enhanced. The goal of computational biology is to study these transitions and discover the different states to fully understand the protein's normal and diseased function, design drugs to target/bias specific states, and understand all of the interactions in between. We have developed a new methodology that is capable of calculating the absolute free energy of proteins while taking into account all the interactions with the solvent molecules. The efficiency of the new scheme is an order of magnitude greater than any existing technique. This method is now implemented in the massively parallel popular MD program package NAMD. This now makes it possible to calculate the relative stability of different conformational states of biological macromolecules as well as their binding free energies to various ligands.

  7. Monovalent Ions and Water Dipoles in Contact with Dipolar Zwitterionic Lipid Headgroups-Theory and MD Simulations

    Directory of Open Access Journals (Sweden)

    Aljaž Velikonja

    2013-01-01

    Full Text Available The lipid bilayer is a basic building block of biological membranes and can be pictured as a barrier separating two compartments filled with electrolyte solution. Artificial planar lipid bilayers are therefore commonly used as model systems to study the physical and electrical properties of the cell membranes in contact with electrolyte solution. Among them the glycerol-based polar phospholipids which have dipolar, but electrically neutral head groups, are most frequently used in formation of artificial lipid bilayers. In this work the electrical properties of the lipid layer composed of zwitterionic lipids with non-zero dipole moments are studied theoretically. In the model, the zwitterionic lipid bilayer is assumed to be in contact with aqueous solution of monovalent salt ions. The orientational ordering of water, resulting in spatial variation of permittivity, is explicitly taken into account. It is shown that due to saturation effect in orientational ordering of water dipoles the relative permittivity in the zwitterionic headgroup region is decreased, while the corresponding electric potential becomes strongly negative. Some of the predictions of the presented mean-field theoretical consideration are critically evaluated using the results of molecular dynamics (MD simulation.

  8. Chronological constraints on Cordilleran Ice Sheet glaciomarine sedimentation from core MD02-2496 off Vancouver Island (western Canada)

    Science.gov (United States)

    Cosma, T. N.; Hendy, I. L.; Chang, A. S.

    2008-05-01

    Chronology based on 46 radiocarbon dates has been generated for MD02-2496, western Vancouver Island, Canada. Subsequent correlation between glaciomarine sedimentary sequences within the core and the terrestrial stratigraphy of the Cordilleran Ice Sheet for the last 50 ka provide new insight into Cordilleran Ice Sheet processes. Glaciomarine sedimentation associated with the most recent advance (Fraser Glaciation) of the Cordilleran Ice Sheet began at 30.5 cal kyr BP (˜25 14C kyr BP). Extremely high sedimentation rates indicate the ice sheet became proximal to the site at ˜19.5 cal kyr BP (16 14C kyr BP). Deposition of ice rafted detritus (IRD) began at ˜17 cal kyr BP (14 14C kyr BP), and abruptly terminated at ˜16.2 cal kyr BP (13.5 14C kyr BP) indicating rapid regional ice sheet retreat. A minor IRD event followed at ˜14.7 cal kyr BP (12.5 14C kyr BP). Glaciomarine sediment deposition abruptly ended at 10.2 cal kyr BP (˜8.8 14C kyr BP) with the resumption of biogenic sedimentation. The Olympia Interstade is represented by an interval of hemipelagic sedimentation between ˜43 and 31.5 ka. Prior to ˜45 ka sediment deposition is controlled by glaciomarine processes with evidence for a significant IRD event at ˜47 cal kyr BP (>41±1.06 14C kyr BP).

  9. Experiences in the continuous improvement of quality assurance of the dosimetry services of SLDC-MD-ININ

    International Nuclear Information System (INIS)

    From 2003 the Secondary Laboratory of Dosimetric Calibration (SLDC) of Metrology Department of Ionizing Radiations (MD), has complemented the Quality Manual of National Institute of Nuclear Research (ININ) according to the standard ISO 9001: 2000. However, due to that the National Center of Metrology of Mexico delegates its functions in the dosimetry and activity area for the field of the ionizing radiations to the ININ: one of the requirements so that the ININ has been designated as -Declared Institute- before the International Office of Weights and Measurements, it is to demonstrate before the Inter-American System of Metrology that the quality system of the SLDC fulfills the standard ISO/IEC 17025: 2005, satisfied this requirement the Inter-American System of Metrology in their meeting of evaluation of quality systems, Ottawa (2007) grants a certification document to the SLDC that guarantees their capacities of calibration measurements for dosimetry services. Concretely, inside the standard activities ISO 9000 with respect to the point 8 on measurement, analysis and improvement the Management of Quality Assurance of ININ carries out at year two interns auditing and every month is given continuation to the non conformities detected in the procedures that support the services of the SLDC for dosimetry with purposes of radiological protection and clinical dosimetry. (Author)

  10. MD investigation of thermal spike effects on defect production and disordering by displacement cascades in Ni3Al

    International Nuclear Information System (INIS)

    Molecular dynamics (MD) simulations are used to obtain detailed information on defect production and disordering produced in the primary cascade state of radiation damage in Ni3Al as a function of irradiation temperature, Tirr. Although the number of Frenkel pairs decreases with increasing Tirr, the size of interstitial clusters and the interstitial clustering fraction increase with Tirr. The number of antisites defects per cascade increases by about 20% as Tirr increases from 100 to 600K, and then by about 90% from 600 to 900K due to the increase in the intensity and lifetime of the thermal spike. The average size of disordered zones at different Tirr is compared with experimental transmission electron microscopy data and the results are in reasonable agreement. The long-range order parameter in the cascade region is found to be consistent with values obtained experimentally on Ni3Al irradiated by ions to a similar dose. The chemical short-range order parameter is about 0.6 over the whole range of Tirr considered, suggesting that the cascade core retains some short-range order at high temperature due to local reordering

  11. HYDRAULICS, CHARLES COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  12. HYDRAULICS, GARRETT COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  13. SURVEY, Cecil County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  14. Selling brand MD.

    Science.gov (United States)

    Hudson, T

    1999-08-01

    Health care is more than local, of course: It's personal. Recognizing the connections between doctors and patients as a potent form of brand loyalty, health systems are looking for ways to leverage those bonds--and encourage new ones--with special marketing campaigns. PMID:10528585

  15. SURVEY, CHARLES COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  16. HYDRAULICS, KENT COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  17. BASEMAP, CAROLINE COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  18. FLOODPLAIN, Caroline County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  19. SURVEY, Caroline COUNTY, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The field survey data for this coastal study includes a field report that exhibits photos and transect information collected in the field survey phase of the study....

  20. ORTHOIMAGERY, Cecil County, MD

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Digital orthographic imagery datasets contain georeferenced images of the Earth's surface, collected by a sensor in which object displacement has been removed for...