David Bruce Payton : väikeriigid mõistavad üksteist / David Bruce Payton ; interv. Marianne Mikko

Index Scriptorium Estoniae

Payton, David Bruce

2003-01-01

Uus-Meremaa suursaadik Eestis David Bruce Payton talupidaja toetamise loobumisest Uus-Meremaal, Uus-Meremaa põllumajandussektorist, veinidest, ekspordist, Eesti saamisest EL-i ja NATO liikmeks, Uus-Meremaa rahvastikust, elatustasemest, Iraagi võimalikust ründamisest, Põhja-Koreast

Bruce Springsteen as a Symbol

DEFF Research Database (Denmark)

Gitz-Johansen, Thomas

2018-01-01

The article explores how Bruce Springsteen and his music function as a symbol. The article first presents the Jungian theory of symbols and of music as symbol. The central argument of the article is that, by functioning symbolically, Springsteen has the potential to influence the psyche of his au...

Challenges of restarting Bruce Units 3 and 4 from a chemistry and materials perspective

International Nuclear Information System (INIS)

Roberts, J.G.; Langguth, K.

2005-01-01

In 2001, Bruce Power leased the Bruce Units 1-8 reactors from Ontario Power Generation. Bruce Power decided to restart Bruce Units 3 and 4 following a condition assessment of Bruce A Units 3 and 4. This paper describes the challenges that were encountered and how they were overcome, specifically for heat transport system chemistry in order to adequately protect carbon steel surfaces. The heat transport system, by design, has close inter-relations with other station systems and the related issues of some of these systems are also discussed. Considerations of material impacts have significant influences on the approach to, and control of, chemistry. Specific material impacts led to a novel, and successful, approach. This approach was arrived at following significant efforts by a multi-disciplinary team of operations, maintenance and chemistry staff. The issues, approaches considered and solutions used for a successful outcome will be presented. (author)

Challenges of restarting Bruce Units 3 and 4 from a chemistry and materials perspective

Energy Technology Data Exchange (ETDEWEB)

Roberts, J.G.; Langguth, K. [Bruce Power, Tiverton, Ontario (Canada)

2005-07-01

In 2001, Bruce Power leased the Bruce Units 1-8 reactors from Ontario Power Generation. Bruce Power decided to restart Bruce Units 3 and 4 following a condition assessment of Bruce A Units 3 and 4. This paper describes the challenges that were encountered and how they were overcome, specifically for heat transport system chemistry in order to adequately protect carbon steel surfaces. The heat transport system, by design, has close inter-relations with other station systems and the related issues of some of these systems are also discussed. Considerations of material impacts have significant influences on the approach to, and control of, chemistry. Specific material impacts led to a novel, and successful, approach. This approach was arrived at following significant efforts by a multi-disciplinary team of operations, maintenance and chemistry staff. The issues, approaches considered and solutions used for a successful outcome will be presented. (author)

Universal delivery machine - design of the Bruce and Darlington heads

International Nuclear Information System (INIS)

Gray, M.G.; Brown, R.

2003-01-01

The Universal Delivery Machine (UDM) was designed and supplied to reduce the time required to perform channel inspection services. The Bruce UDM was the first to be completed followed by Pickering and Darlington. The Bruce and Darlington machines are nearly identical. Design concepts applied include a rotating, multiple tool station magazine, a rigid chain driving telescoping rams, a common drive package, and an external support frame to meet seismic qualification requirements. (author)

Bruce used fuel dry storage project evolution from Pickering to Bruce

International Nuclear Information System (INIS)

Young, R.E.

1996-01-01

Additional fuel storage capacity is required at Bruce Nuclear Generating Station, which otherwise would soon fill up all its pool storage capacity. The recommended option was to use a dry storage container similar to that at Pickering. The changes made to the Pickering type of container included: fuel to be stored in trays; the container's capacity increased to 600 bundles; the container's lid to be changed to a metal one; the single concrete lid to be changed to a double metal lid system; the container not to be transportable; the container would be dry-loaded. 7 figs

Bruce used fuel dry storage project evolution from Pickering to Bruce

Energy Technology Data Exchange (ETDEWEB)

Young, R E [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1997-12-31

Additional fuel storage capacity is required at Bruce Nuclear Generating Station, which otherwise would soon fill up all its pool storage capacity. The recommended option was to use a dry storage container similar to that at Pickering. The changes made to the Pickering type of container included: fuel to be stored in trays; the container`s capacity increased to 600 bundles; the container`s lid to be changed to a metal one; the single concrete lid to be changed to a double metal lid system; the container not to be transportable; the container would be dry-loaded. 7 figs.

Instrument calibration optimization at Bruce Power: ECI loops

International Nuclear Information System (INIS)

Chugh, V.; Angelova, M.; Ghias, S.; Parmar, R.; Wang, V.; Xie, H.; Higgs, J.; Schut, J.; Cruchley, I.

2011-01-01

Most instruments in a nuclear power plant are calibrated at regular intervals to ensure consistency with the assumptions in the plant Technical Specifications and/or Safe Operating Envelope (SOE) compliance limits (e.g., As-Found Tolerance). In the Instrument Uncertainty Calculations (IUC), As-Found Tolerance for instrument drift is estimated based on statistical analysis of As-Found and As-Left calibration data such as that carried out for Bruce NGS by EPRI (Electric Power Research Institute) in 1998. Bruce specific drift values were found to compare favorably with industry benchmarks. Recently a significant amount of work has been done by EPRI and IAEA (International Atomic Energy Agency) on extending calibration intervals of safety related instruments. Reduction in calibration frequency reduces time commitments on the part of Authorized Nuclear Operators and safety system qualified Control Maintenance Technicians, and allows more schedule flexibility. To establish the proof of concept, As-Left/As-Found tolerances and available margins have been evaluated for the Bruce B Emergency Coolant Injection (ECI) system instrument loops to determine whether an extension of the calibration period from one or two year to three years is justifiable on the basis that these loops will still be in compliance with SOE. The analysis showed that 60% of instruments in the ECI system are qualified for calibration interval extension up to three years. Sensitivity assessment of the effect of proposed changes in calibration intervals for 60% of the instruments on the ECI system unavailability has also been performed using the current Bruce Power ECI unavailability model. The results show that, the largest ECI Predicted Future Unavailability (PFU) is 9.2E-4 year/year for in-core LOCA accident. This value is still below the target unavailability of 1.0E-3 year/year. (author)

Instrument calibration optimization at Bruce Power: ECI loops

Energy Technology Data Exchange (ETDEWEB)

Chugh, V.; Angelova, M.; Ghias, S.; Parmar, R.; Wang, V.; Xie, H. [AMEC NSS, Toronto, Ontario (Canada); Higgs, J.; Schut, J.; Cruchley, I. [Bruce Power, Tiverton, Ontario (Canada)

2011-07-01

Most instruments in a nuclear power plant are calibrated at regular intervals to ensure consistency with the assumptions in the plant Technical Specifications and/or Safe Operating Envelope (SOE) compliance limits (e.g., As-Found Tolerance). In the Instrument Uncertainty Calculations (IUC), As-Found Tolerance for instrument drift is estimated based on statistical analysis of As-Found and As-Left calibration data such as that carried out for Bruce NGS by EPRI (Electric Power Research Institute) in 1998. Bruce specific drift values were found to compare favorably with industry benchmarks. Recently a significant amount of work has been done by EPRI and IAEA (International Atomic Energy Agency) on extending calibration intervals of safety related instruments. Reduction in calibration frequency reduces time commitments on the part of Authorized Nuclear Operators and safety system qualified Control Maintenance Technicians, and allows more schedule flexibility. To establish the proof of concept, As-Left/As-Found tolerances and available margins have been evaluated for the Bruce B Emergency Coolant Injection (ECI) system instrument loops to determine whether an extension of the calibration period from one or two year to three years is justifiable on the basis that these loops will still be in compliance with SOE. The analysis showed that 60% of instruments in the ECI system are qualified for calibration interval extension up to three years. Sensitivity assessment of the effect of proposed changes in calibration intervals for 60% of the instruments on the ECI system unavailability has also been performed using the current Bruce Power ECI unavailability model. The results show that, the largest ECI Predicted Future Unavailability (PFU) is 9.2E-4 year/year for in-core LOCA accident. This value is still below the target unavailability of 1.0E-3 year/year. (author)

Bruce A - performance power

Energy Technology Data Exchange (ETDEWEB)

Boucher, P. [Bruce Power, Tiverton, ON (Canada)

2015-07-01

This paper discusses the strategy for improving performance at Bruce Power. The key to excellence is changing behaviours. Reinforcing and enforcing expectations, aligned with the 2015 operating to the Highest Standards Site Initiative. Long term equipment strategies, supported by the 2015 Equipment Health Site Initiative, individual and group accountability for online/outage Work Management, with further gains through 2015 Maintenance Alignment and Resource Strategy (MARS) Site Initiative. Results showed human performance improvement, more reliable and predictable units and outage performance improvement.

CECIL lances Bruce's boilers

International Nuclear Information System (INIS)

Malaugh, J.; Monaghan, D.

1994-01-01

Over the past few years Ontario Hydro has become increasingly concerned about accumulations of sludge in its nuclear plant boilers, so a comprehensive sludge management programme has been instituted to combat build-up. This included developing the tele-operated robot CECIL (Consolidated Edison Combined Inspection and Lancing) equipment, originally designed for work in PWRs, for CANDU boilers. This required a significantly reconfigured robotic system as well as modifications to the boilers themselves. Work on the Bruce A reactor is described. (4 figures). (author)

The Bruce Medalists

Science.gov (United States)

Tenn, J. S.

2001-12-01

The Astronomical Society of the Pacific (ASP) has presented the Catherine Wolfe Bruce gold medal for lifetime contributions to astronomy most years since 1898. The 94 medalists include most of the scientists whose work has greatly changed astronomy since the late nineteenth century: Huggins, Pickering, Campbell, Hale, Eddington, Russell, Adams, Slipher, Hertzsprung, Hubble, Shapley, Oort, Baade, ... Major exceptions include those who died young, those who worked in teams, and, in the early years, women. Mathematicians appear to have been as likely to be honored as astronomers from the beginning, but the fortunes of physicist nominees have varied. The nomination process is an unusual one, with the directors of six observatories, three in the U.S. and three abroad, asked to nominate up to three candidates each year. For the first six decades the observatories rarely varied, and directors had long tenures. They nominated the same individuals repeatedly. Now both observatories and their directors vary regularly. Much can be learned about the changes in astronomy from the late nineteenth century, when observers worked alone with long refractors and a theorist could spend a lifetime computing the orbit of one comet, to the present, when most papers have multiple authors and a single project may include millions of objects. For example, celestial mechanics was the specialty of many of the early medalists but none since 1966. I have posted photographs, brief biographies, extensive bibliographies, and links to publications by and about all of the medalists, from Simon Newcomb in 1898 to Hans Bethe in 2001, at http://phys-astro.sonoma.edu/BruceMedalists/. I will discuss a bit of the history of the medal and some of the medalists.

Non intrusive check valve diagnostics at Bruce A

International Nuclear Information System (INIS)

Marsch, S.P.

1997-01-01

Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

Non intrusive check valve diagnostics at Bruce A

Energy Technology Data Exchange (ETDEWEB)

Marsch, S.P. [Ontario Hydro, Bruce Nuclear Generating Station A, Tiverton, ON (Canada)

1997-07-01

Bruce A purchased non intrusive check valve diagnostic equipment in 1995 to ensure operability and availability of critical check valves in the Station. Diagnostics can be used to locate and monitor check valve degradation modes. Bruce A initiated a pilot program targeting check valves with flow through them and ones that completed open or close cycles. Approaches to determine how to confirm operability of passive check valves using non intrusive techniques were explored. A sample population of seventy-three check valves was selected to run the pilot program on prior to complete implementation. The pilot program produced some significant results and some inconclusive results. The program revealed a major finding that check valve performance modeling is required to ensure continuous operability of check valves. (author)

An Appreciation of the Scientific Life and Acheivements of Bruce Merrifield

Energy Technology Data Exchange (ETDEWEB)

Mitchell, R

2007-06-15

Bruce Merrifield's scientific biography, 'Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis', provides a history of solid phase-peptide synthesis (SPPS) from 1959 to 1993 [1]. While many readers will be familiar with SPPS literature after 1963, the inclusion of unpublished material from Merrifield's early laboratory notebooks opens a fascinating window on the development of SPPS from the formulation of concept in 1959 (p. 56, ref. 1) to the synthesis of a tetrapeptide four years later [2]. This early period was characterized by slow progress interrupted by numerous setbacks that led Bruce to later record (p. 90, ref. 1): 'At the end of the first two years the results were so poor, I wonder what made me think that this approach would ever succeed; but from the outset I had a strong conviction that this was a good idea, and I am glad that I stayed with it long enough'. Garland Marshall, Bruce's first graduate student (1963-1966), as well as later colleagues, were essentially unaware of the many highways, byways and dead ends that Bruce had explored in the early years [3].

Bruce NGS A Unit 4 preheater divider plate failure

International Nuclear Information System (INIS)

Landridge, M.; McInnes, D.

1995-01-01

On May 19, 1995, without any prior operational indications, Bruce A discovered preheater divider plate damage in Unit 4 that had the potential to have a major impact on the continued safe operation of the station. Further investigations indicated that Unit 4 may have been operating with this damage for as long as ten years. In the two months following the discovery, Bruce A has procured and replaced the 4 divider plates, located most of the missing pieces, retrieved pieces from the PHT system, investigated historical operational information, performed detailed analytical investigations, investigated root cause, performed in-situ and mock-up testing, updated operational procedures and installed DP monitoring equipment

AECB staff annual assessment of the Bruce A Nuclear Generating Station for the year 1995

International Nuclear Information System (INIS)

1996-06-01

The Atomic Energy Control Board conducts a staff assessment of safety at Bruce Nuclear Generating Station A for 1995. On-site Project Officers and Ottawa based specialists monitored the station throughout the year. Ontario Hydro operated Bruce A safely in 1995, maintaining the risk to workers and the public at an acceptably low level. Radiation doses to workers and releases to the environment were well below regulatory limits. However, Ontario Hydro must improve contamination control at Bruce A. Special safety system performance a Bruce A was less than adequate. The negative pressure containment system and units 4's shutdown system two exceeded unavailability targets in 1995. However, we are satisfied Ontario Hydro is taking appropriate action to correct this. 5 tabs., 5 figs

Bruce Power's nuclear pressure boundary quality assurance program requirements, implementation and transition

International Nuclear Information System (INIS)

Krane, J.C.

2009-01-01

The development of a full scope nuclear pressure boundary quality assurance program in Canada requires extensive knowledge of the structure and detailed requirements of codes and standards published by the Canadian Standards Association (CSA) and American Society of Mechanical Engineers (ASME). Incorporation into company governance documents and implementation of these requirements while managing the transition to more recent revisions of these codes and standards represents a significant challenge for Bruce Power, Canada's largest independent nuclear operator. This paper explores the key developments and innovative changes that are used to ensure successful regulatory compliance and effective implementation of the Bruce Power Pressure Boundary Quality Assurance Program. Challenges and mitigating strategies to sustain this large compliance based program at Bruce Power's 8 unit nuclear power plant site will also be detailed. (author)

AECB staff annual report of Bruce NGS 'B' for the year 1988

International Nuclear Information System (INIS)

1989-05-01

The operation of the Bruce 'B' Nuclear Generating Station is monitored and licensing requirements are enforced by the Atomic Energy Control Board (AECB) Bruce project staff, with appropriate support from other AECB personnel. The staff observes operation of the reactors, conducts audits, witnesses important activities, reviews station documentation and reports, and issues approvals where appropriate in accordance with license conditions. As required by a condition of its Operating Licence, Ontario Hydro each year submits Technical Reports which summarize various aspects of the operation of Bruce NGS 'B' during the year. When these reports have been reviewed by AECB staff, a formal Annual Review Meeting is held with the station management to discuss safety-related aspects of the station operation, and to inform Ontario Hydro of AECB staff conclusions with respect to the performance of Ontario Hydro in operating the station during the year

Exercise testing of pre-school children using the Bruce treadmill protocol: new reference values

NARCIS (Netherlands)

M.H.M. van der Cammen-van Zijp (Monique); H. IJsselstijn (Hanneke); T. Takken (Tim); S.P. Willemsen (Sten); D. Tibboel (Dick); H.J. Stam (Henk); H.J.G. van den Berg-Emons (Rita)

2010-01-01

textabstractThe Bruce treadmill protocol is an often-used exercise test for children and adults. Few and mainly old normative data are available for young children. In this cross-sectional observational study we determined new reference values for the original Bruce protocol in children aged 4 and 5

AECB staff annual assessment of the Bruce B Nuclear Generating Station for the year 1996

International Nuclear Information System (INIS)

1997-06-01

The Atomic Energy Control Board is the independent federal agency that controls all nuclear activities in Canada. A major use of nuclear energy in Canada is electricity production. The AECB assesses every station's performance against legal requirements, including the conditions in the operating licence. Each station is inspected and all aspects of the station's operation and management is reviewed. This report is the AECB staff assessment of reactor safety at the Bruce Nuclear Generating Station B for 1996. It was concluded that Ontario Hydro operated Bruce B safely in 1996. Although the Bruce B plant is safe,it was noted that the number of outages and the number of secondary and tertiary equipment failures during reactor unit upsets increased. Ontario Hydro needs to pay special attention to prevent such a decrease in the safety performance at Bruce B

Geoscientific Characterization of the Bruce Site, Tiverton, Ontario

Science.gov (United States)

Raven, K.; Jackson, R.; Avis, J.; Clark, I.; Jensen, M.

2009-05-01

Ontario Power Generation is proposing a Deep Geologic Repository (DGR) for the long-term management of its Low and Intermediate Level Radioactive Waste (L&ILW) within a Paleozoic-age sedimentary sequence beneath the Bruce site near Tiverton, Ontario, Canada. The concept envisions that the DGR would be excavated at a depth of approximately 680 m within the Ordovician Cobourg Formation, a massive, dense, low- permeability, argillaceous limestone. Characterization of the Bruce site for waste disposal is being conducted in accordance with a four year multi-phase Geoscientific Site Characterization Plan (GSCP). The GSCP, initially developed in 2006 and later revised in 2008 to account for acquired site knowledge based on successful completion of Phase I investigations, describes the tools and methods selected for geological, hydrogeological and geomechanical site characterization. The GSCP was developed, in part, on an assessment of geoscience data needs and collection methods, review of the results of detailed geoscientific studies completed in the same bedrock formations found off the Bruce site, and recent international experience in geoscientific characterization of similar sedimentary rocks for long-term radioactive waste management purposes. Field and laboratory work related to Phase 1 and Phase 2A are nearing completion and have focused on the drilling, testing and monitoring of four continuously cored vertical boreholes through Devonian, Silurian, Ordovician and Cambrian bedrock to depths of about 860 mBGS. Work in 2009 will focus on drilling and testing of inclined boreholes to assess presence of vertical structure. The available geological, hydrogeological and hydrogeochemical data indicate the presence of remarkably uniform and predictable geology, physical hydrogeologic and geochemical properties over well separation distances exceeding 1 km. The current data set including 2-D seismic reflection surveys, field and lab hydraulic testing, lab petrophysical and

The fuel string relocation effect - why the Bruce reactors were derated

Energy Technology Data Exchange (ETDEWEB)

Gold, M; Farooqui, M Z; Adebiyi, A S; Chu, R Y; Le, N T; Oliva, A F [Ontario Hydro, Toronto, ON (Canada); Balog, G; Qu, T; DeBuda, P G [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1996-12-31

In the CANDU Safety Analysis process, a series of design basis accidents are chosen and analyzed to confirm safety system effectiveness. Of all the postulated accidents, the Large Break Loss of Coolant Accident (LBLOCA) - a postulated break in the Heat Transport System piping near a component that services a large number of fuel channels - sets the most demanding requirements on the speed and reactivity depth of the shutdown system devices - shutoff rods and liquid poison injection. While the event is extremely improbable, it is reanalyzed periodically and its consequences examined to ensure continued shutdown system effectiveness. In March 1993, an additional effect was identified: if the break occurred in the piping on the inlet side of the core, this would cause sudden movement of the fuel bundles (so-called fuel string relocation) in a large number of channels. In Ontario Hydro`s Bruce NGS A, Bruce NGS B and Darlington reactors, each channel is fuelled against the flow. In this situation, the relocation of the fuel string results in a sudden positive reactivity increase. This reactivity increase is in addition to the reactivity due to the core coolant voiding. The combined reactivity effect could lead to power pulses much higher than those that would arise due to coolant voiding alone. To maintain safety margins in the event of such a postulated accident, the eight Bruce NGS A and Bruce NGS B units were initially derated to 60 percent power within 2 days of the identification and confirmation of this effect. This paper: describes the fuel string relocation phenomenon in detail; explains why the consequences differ at the various Ontario Hydro reactors; outlines the actions taken with respect to each of the Ontario Hydro reactors in the months following March 1993; describes the design solutions implemented to mitigate the problem and return the Bruce reactors to higher powers. 6 refs., 1 tab., 6 figs.

Steam generator replacement in Bruce A Unit 1 and Unit 2

International Nuclear Information System (INIS)

Hart, R.S.

2006-01-01

The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Units 2 that will extend the in-service life of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from the bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

Waste repository planned for Bruce Site

International Nuclear Information System (INIS)

King, F.

2004-01-01

Ontario Power Generation (OPG) and Kincardine, the municipality nearest the Bruce site, have agreed in principal to the construction of a deep geologic repository for low and medium level radioactive waste on the site. The two parties signed the 'Kincardine Hosting Agreement' on October 13, 2004 to proceed with planning, seek regulatory approval and further public consultation of the proposed project. A construction Licence is not expected before 2013. (author)

Steam generator replacement in Bruce A Unit 1 and Unit 2

International Nuclear Information System (INIS)

Hart, R.S.

2007-01-01

The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Unit 2 that will extend the in-service tile of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from he bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

Status of the reliability centered maintenance program at Ontario Hydro's Bruce 'A' Nuclear Division

International Nuclear Information System (INIS)

Khan, I.

1995-01-01

Bruce A started a preventive maintenance (PM) quality improvement program in August of 1991. This initiative was taken to address the concerns expressed by the AECB and the Peer Audits finding. The concerns were on the quality of the Bruce A PM Program and its execution in the field. Reliability Centered Maintenance (RCM) analysis was selected as the PM program quality improvement and optimization technique. Therefore, RCM became a key component of Bruce A's Integrated PM program and maintenance strategy. As a result of RCM implementation, and improvements in the work planning and scheduling process, Bruce A is seeing downward trends in the corrective maintenance work load, maintenance preventable forced outages, overdue/missed PM tasks and corrective maintenance backlog. Control Room Operators have reported observing an improvement in systems and equipment response to transients. Other benefits include a documented, controlled and traceable PM program. In addition, the team approach required by RCM has started to improve staff confidence in the PM program which, in turn, is improving the compliance with the PM program. (author)

Ontario Hydro's operating experience with steam generators with specifics on Bruce A and Bruce B problems

Energy Technology Data Exchange (ETDEWEB)

Eatock, J W; Patterson, R W [Ontario Hydro, Toronto, ON (Canada); Dyck, R W [Ontario Hydro, Central Production Services Division, Toronto, ON (Canada)

1991-04-01

The performance of the steam generators in Ontario Hydro nuclear power stations is reviewed. This performance has generally been outstanding compared to world averages, with very low tube failure and plugging rates. Steam generator problems have made only minor contributions to Ontario Hydro nuclear station incapability factors. The mechanisms responsible for the the observed tube degradation and failures are described. The majority of the leaks have been due fatigue in the U-bend of the Bruce 'A' steam generators. There have been very few failures attributed to corrosion of the three tube materials used in Ontario Hydro steam generators. Recent performance has been deteriorating primarily due to deposit accumulation in the steam generators. Plugging of the broached holes in the upper support plates at Bruce 'A' has caused some derating of two units. Increases have been observed in the primary heat transport system reactor inlet temperature of several units. These increases may be attributed to steam generator tube surface fouling. In addition, several units have accumulated deep, hard sludge piles on the tube sheet, although little damage been observed. Recently some fretting of tubes has been observed at BNGSB in the U-bend support region. Remedial measures are being taken to address the current problems. Solutions are being evaluated to reduce the generation of corrosion products in the feedtrain and their subsequent transport to the steam generators. (author)

Ontario Hydro's operating experience with steam generators with specifics on Bruce A and Bruce B problems

International Nuclear Information System (INIS)

Eatock, J.W.; Patterson, R.W.; Dyck, R.W.

1991-01-01

The performance of the steam generators in Ontario Hydro nuclear power stations is reviewed. This performance has generally been outstanding compared to world averages, with very low tube failure and plugging rates. Steam generator problems have made only minor contributions to Ontario Hydro nuclear station incapability factors. The mechanisms responsible for the the observed tube degradation and failures are described. The majority of the leaks have been due fatigue in the U-bend of the Bruce 'A' steam generators. There have been very few failures attributed to corrosion of the three tube materials used in Ontario Hydro steam generators. Recent performance has been deteriorating primarily due to deposit accumulation in the steam generators. Plugging of the broached holes in the upper support plates at Bruce 'A' has caused some derating of two units. Increases have been observed in the primary heat transport system reactor inlet temperature of several units. These increases may be attributed to steam generator tube surface fouling. In addition, several units have accumulated deep, hard sludge piles on the tube sheet, although little damage been observed. Recently some fretting of tubes has been observed at BNGSB in the U-bend support region. Remedial measures are being taken to address the current problems. Solutions are being evaluated to reduce the generation of corrosion products in the feedtrain and their subsequent transport to the steam generators. (author)

Clean energy for a new generation. Steam generator life cycle management and Bruce restart

International Nuclear Information System (INIS)

Newman, G.W.

2009-01-01

In the mid to late 1990s, Ontario Hydro decided to lay-up and write-down the Bruce A Nuclear Reactors. Upon transition to Bruce Power L.P., Canada's first and only private nuclear operator, new life and prospects were injected into the site, local economy and the provincial energy portfolio. The first step in this provincial power recovery initiative involved restart of Bruce Units 3 and 4 in the 2003/04 time-frame. Units 3 and 4 have performed beyond expectation during the last five-year operating interval. A combination of steam generator and fuel channel issues precluded a similar restart of Units 1 and 2. Enter the refurbishment of Bruce Units 1 and 2. This first-of-a-kind undertaking within the Canadian nuclear power industry is testament to the demonstrated industry leadership by Bruce Power L.P., their investors and the significant vendor community contribution that is supporting this major power infrastructure enhancement. Initiated as a 'turn-key' project solution separated from the operating units, this major refurbishment project has evolved to a fully managed in-house refurbishment project with the continued support from the broader vendor community. As part of this first-of-kind undertaking, Bruce Power L.P. is in the process of accomplishing such initiatives as a complete fuel channel re-tube (i.e. full core calandria and pressure tube replacement), replacement of all boilers (i.e. 16 in total) and the majority of feeder pipe replacement. Complimentary major upgrades and replacement of the remainder of plant equipment including both nuclear and non-nuclear valves, heat exchangers, electrical infrastructure, service water systems and components, all while meeting a parallel evolving/maturing regulatory environment related to achieving compliance with IAEA derived modern codes and standards. Returning to ground level, boiler replacement is a key part of the refurbishment undertaking and this further reflected a meeting of the 'old' and the 'new'. Pre

Ion chamber repairs in Bruce A

International Nuclear Information System (INIS)

Millard, J.; Edwards, T.; Kerker, J.; Pletch, R.; Edwards, T.

2012-01-01

This paper discusses identification and successful remediation of leakage of shield tank water on vertical and horizontal Ion Chambers in Bruce A. In doing so, it discusses real events moving from the initial investigation to understand the problem, through looking at options for solutions, and moving to site work and actual resolution.. In multiunit 900 MW class CANDU® reactors, the calandria vessel is suspended within a larger shield tank. Due to temperature changes or changes in moderator fluid levels in the calandria, the calandria can move relative to the shield tank and its reactivity deck. Thimbles which contain the reactivity sensors and controls connect the two vessels and allow the reactivity drives and controls connections to be placed on the deck structure on the top of the reactor assembly for RRS and SDS1 and horizontally for SDS2. These thimbles have expansion joints with metal bellows where they meet the deck structure or shield tank walls. The deck structure lies on a vault containment boundary. The horizontal ion chambers are not in the containment boundary as they connect the outside of the calandria and shield tank around mid plane in the reactor vault, but due to geometry difference provides a more challenging work environment. Bruce had a beetle alarm (1-63851-MIA2-ME30 in alarm state (vertical IC housing)) at the start of April 2012 on Unit 1 channel F vertical Ion chamber expansion joint at the deck connection. This occurred after the moderator levels had been raised after the several years long refurbishment outage and the expansion joint had a significant travel. The investigation showed shield tank water in the collection chamber at the beetle. In addition, Channel J of the horizontal ion chamber had a seized instrument, which on removal was found to relate to oxide build up as a result of minor water leakage into the site. Repairs in both cases were performed as part of the long Bruce 1 & 2 refurbishment outage to completely stop the

Fire fighting capability assessment program Bruce B NGS

International Nuclear Information System (INIS)

1995-05-01

This is a report on the completion of work relating to the assessment of the capability of Bruce B NGS to cope with a large fire incident. This included an evaluation of an exercise scenario that would simulate a large fire incident and of their fire plans and procedures. Finally the execution of fire plans by Bruce B NGS, as demonstrated by their application of human and material resources during a simulated large fire, was observed. The fire fighting equipment and the personal protective clothing and associated equipment that was in use was all of good quality and in good condition. There had also been notable improvement in communications equipment. Similarly, the human resources that had been assigned to fire fighting and rescue crews and that were available were more than adequate. Use of a logical incident command system, and the adoption of proper policy and procedures for radio communications were equally significant improvements. Practice should correct the breakdowns that occurred in these areas during the exercise. As well, there remains a need for the development of policy on fire fighting and rescue operations with more depth and clarity. In summary, the key point to be recognized is the degree of improvement that has been realized since the previous evaluation in 1990. Clearly the Emergency Response Teams organization of Bruce B NGS is evolving into an effective fire fighting force. Providing that the deficiencies identified in this report are addressed satisfactorily, Fire Cross is confident that the organization will have the capability to provide rescue and fire fighting services that will satisfy the need. 2 figs

Projecting Dynastic Majesty: State Ceremony in the Reign of Robert Bruce

Directory of Open Access Journals (Sweden)

Lucinda Dean

2015-07-01

Full Text Available Following the murder of his rival John Comyn on 10 February at Greyfriars in Dumfries, and the crisis this act incited, Robert the Bruce’s inaugural ceremony took place at Scone in late March 1306. Much about this ceremony is speculative; however, subsequent retrospective legitimisation of the Bruce claims to the royal succession would suggest that all possible means by which Robert’s inauguration could emulate his Canmore predecessors and outline his right to rule on a level playing field with his contemporaries were amplified, particularly where they served the common purpose of legitimising Robert’s highly questioned hold on power. Fourteenth-century Scottish history is inextricably entwined in the Wars of Independence, civil strife and an accelerated struggle for autonomous rule and independence. The historiography of this period is unsurprisingly heavily dominated by such themes and, while this has been offset by works exploring subjects such as the tomb of Bruce and the piety of the Bruce dynasty, the ceremonial history of this era remains firmly in the shadows. This paper will address three key ceremonies through which a king would, traditionally, make powerful statements of royal authority: the inauguration or coronation of Bruce; the marriage of his infant son to the English princess Joan of the Tower in 1328, and his extravagant funeral ceremony in 1329. By focusing thus this paper hopes to shed new light on the ‘dark and drublie days’ of fourteenth-century Scotland and reveal that glory, dynastic majesty and pleasure were as central to the Scottish monarchy in this era as war and political turbulence.

Bruce and Darlington power pulse and pressure tube integrity programs -status 1995

Energy Technology Data Exchange (ETDEWEB)

Field, G J [Atomic Energy of Canada Ltd., Mississauga, ON (Canada); Wylie, J [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1996-12-31

The optimum solution to pressure tube fretting at the inlet of the Bruce and Darlington channels, a concern which became very serious following inspections in early 1992, is to remove the inlet bundle and operate with a 12 fuel bundle channel. During analysis of this operating mode a `power pulse` was identified which could occur during an inlet header break where all the fuel in the channel moved rapidly to the inlet of the channel. The pulse was unacceptable and the units were derated until solutions could be implemented. A number of solutions were identified and each station has begun implementation of their specific solution. Implementation has not been without problems and this paper provides a status report on the progress to date of the long bundle implementation solution for Bruce B and Darlington and the fuelling with the flow solution being implemented at Bruce A. Both types of solution have a significant impact on the original concern, fretting of the pressure tube. (author). 1 ref., 6 figs.

Fuel defect detection, localization and removal in Bruce Power units 3 through 8

International Nuclear Information System (INIS)

Stone, R.; Armstrong, J.; Iglesias, F.; Oduntan, R.; Lewis, B.

2005-01-01

Fuel element defects are occurring in Bruce 'A' and Bruce 'B' Units. A root-cause investigation is ongoing, however, a solution is not yet in-hand. Fuel defect management efforts have been undertaken, therefore, in the interim. Fuel defect management tools are in-place for all Bruce Units. These tools can be categorized as analysis-based or operations-based. Analysis-based tools include computer codes used primarily for fuel defect characterization, while operations-based tools include Unit-specific delayed-neutron ('DN') monitoring systems and gaseous fission product ('GFP') monitoring systems. Operations-based tools are used for fuel defect detection, localization and removal activities. Fuel and Physics staff use defect detection, localization and removal methodologies and guidelines to disposition fuel defects. Methodologies are 'standardized' or 'routine' procedures for implementing analysis-based and operations-based tools to disposition fuel defects during Unit start-up operation and during operation at high steady-state power levels. Guidelines at present serve to supplement fuel defect management methodologies during Unit power raise. (author)

AECB staff annual report of Bruce Heavy Water Plant operation for the year 1991

International Nuclear Information System (INIS)

1992-11-01

Bruce Heavy Water Plant operation was acceptably safe in 1991. There were no breaches of any of the regulations issued under the authority of the Atomic Energy Control Act. There was one violation of the operating licence. For one hour on October 30, 1991, water leaving the plant contained more hydrogen sulphide than Ontario regulations allow. There was no threat to public health or safety or harm to the environment as a result of this violation. One worker was overcome by hydrogen sulphide. The worker did not lose consciousness, but had the symptoms of H 2 S poisoning. Ontario Hydro took actions to increase awareness of the Operating Policy and Principles at Bruce Heavy Water Plant during 1991. All personnel attended a training course, and Ontario Hydro is reviewing all Bruce Heavy Water Plant documentation to ensure it is consistent with the Operating Policies and Principles. Ontario Hydro met 13 of 15 safety-related system availability targets. The AECB is satisfied appropriate action is being taken to improve the performance of the other two systems. Ontario Hydro continued to put heavy emphasis on safety training; however, they did not meet some of their other training targets. Ontario Hydro completed all of the planned emergency exercises at Bruce Heavy Water Plant in 1991. (Author)

AECB staff annual assessment of the Bruce A Nuclear Generating Station for the year 1996

International Nuclear Information System (INIS)

1997-06-01

The Atomic Energy Control Board is the independent federal agency that controls all nuclear activities in Canada. A major use of nuclear energy in Canada is electricity production. The AECB assesses every station's performance against legal requirements, including the conditions in the operating licence. Each station is inspected and all aspects of the station's operation and management is reviewed. This report is the AECB staff assessment of reactor safety at the Bruce Nuclear Generating Station A for 1996. Ontario Hydro operated Bruce A safely in 1996, maintaining the risk to workers and the public at an acceptably low level. Special safety system performance at Bruce A was adequate. Availability targets were all met. Improvement is needed to reduce the number of operating licence non-compliances

Business health reporting process at Bruce Power helps drive successful plant performance

International Nuclear Information System (INIS)

Krane, J.C.

2007-01-01

Developing and implementing consistent and comprehensive measures of performance on a large multi-reactor unit nuclear power plant site is a significant challenge. Linking these performance measures back to licence compliance standards and all aspects of the operations, engineering, maintenance and support activities is needed to ensure cohesive site-wide safe operations and satisfy regulatory needs. At Bruce Power, Canada's largest independently-owned nuclear power producer, a Business Health reporting process has been developed to provide a standardized performance rating scheme. The reporting process ties all self assessment activities to common management principles and process structure areas that comprise the Bruce Power Management System. The principles used for performance ratings link directly back to the operating licenses and the primary referenced management system standard. The Business Health reporting process provides a natural business and regulatory oversight framework report that is easily understood and consistently measured over time. The rating data is derived from easily understood quantitative and qualitative descriptions that can be trended over time. The results derived from semi-annual Business Health reports provide an ongoing overall measure of Bruce Power's management system effectiveness for enabling and sustaining required business results and high standards of safety. (author)

AECB staff review of Bruce NGS 'A' operation for the year 1989

International Nuclear Information System (INIS)

1990-06-01

The operation of the Bruce Nuclear Generating Station 'B' is monitored and licensing requirements are enforced by the Atomic Energy Control Board (AECB). This report records the conclusions of the AECB staff assessment of Bruce NGS 'A' during 1989 and the early part of 1990. Overall operation of the station met acceptable safety standards. Despite numerous problems and technical difficulties encountered, station management and supervisory personnel acted with due caution and made decisions in the interests of safety. There was evidence of improvement in a number of key areas, supported by pertinent indicators in the objective measures table. The extensive inspection and maintenance programs carried out during the year revealed the extent of component deterioration due to aging to be larger than expected. Hydrogen embrittlement of pressure tubes, erosion/corrosion of steam and feed water valves, heat exchanger tubes and piping, fouling of boilers and heat exchangers, and environmental damage of electrical equipment are examples. Continued aging of plant equipment and its potential for reducing the margins for safe operation must be taken into account by Ontario Hydro in establishing priorities and target dates for completion of actions to resolve identified problems at Bruce NGS 'A'. (2 tabs.)

Primary separator replacement for Bruce Unit 8 steam generators

International Nuclear Information System (INIS)

Roy, S.B.; Mewdell, C.G.; Schneider, W.G.

2000-01-01

During a scheduled maintenance outage of Bruce Unit 8 in 1998, it was discovered that the majority of the original primary steam separators were damaged in two steam generators. The Bruce B steam generators are equipped with GXP type primary cyclone separators of B and W supply. There were localized perforations in the upper part of the separators and large areas of generalized wall thinning. The degradation was indicative of a flow related erosion corrosion mechanism. Although the unit- restart was justified, it was obvious that corrective actions would be necessary because of the number of separators affected and the extent of the degradation. Repair was not considered to be a practical option and it was decided to replace the separators, as required, in Unit 8 steam generators during an advanced scheduled outage. GXP separators were selected for replacement to minimize the impact on steam generator operating characteristics and analysis. The material of construction was upgraded from the original carbon steel to stainless steel to maximize the assurance of full life. The replacement of the separators was a first of a kind operation not only for Ontario Power Generation and B and W but also for all CANDU plants. The paper describes the degradations observed and the assessments, the operating experience, manufacture and installation of the replacement separators. During routine inspection in 1998, many of the primary steam separators in two of steam generators at Bruce Nuclear Division B Unit 8 were observed to have through wall perforations. This paper describes assessment of this condition. It also discusses the manufacture and testing of replacement primary steam separators and the development and execution of the replacement separator installation program. (author)

The operation and maintenance of the SLAR system at Bruce A

Energy Technology Data Exchange (ETDEWEB)

Ahuja, S [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1997-12-31

The SLAR (Spacer Location And Repositioning) system at Bruce A consists of two (2) Delivery Machines and a Fuelling Machine Trolley equipped with the D{sub 2}0 and Air auxiliary systems. The Delivery Machines are designed to perform all the Fuelling Machine operations and have the capability to rapidly defuel/refuel a reactor channel and traverse the SLAR tool to locate and reposition the spacers in the channel. The number of functions that a Delivery Machine must perform makes it more complex as compared to the operations of a Fuelling Machine. The paper discusses the operation of the SLAR Delivery Machines and the problems encountered with the operation and maintenance of this system at Bruce A. (author). 8 figs.

Fuelling with flow at Bruce A

Energy Technology Data Exchange (ETDEWEB)

Gray, M G [Canadian General Electric Co. Ltd., Peterborough, ON (Canada)

1997-12-31

Fuelling with flow is the solution chosen by Bruce A to overcome the potential power pulse caused by a major inlet header failure. Fuelling with flow solves the problem by rearranging the core to place new fuel at the channel inlet and irradiated fuel at the channel outlet. The change has a significant impact on the Bruce A fuel handling system which was designed primarily to do on power fuelling in the against flow direction. Mechanical changes to the fuelling machine include a modification to the existing ram head and the replacement of standard fuel carriers with new fuelling with flow fuel carriers having the capability of opening the channel latch. Changes to the control system are more involved. A new set of operational sequences are required for both the upstream and downstream fuelling machines to achieve the fuel change. Steps based on sensitive ram push are added to reduce the risk of failing to close the latch at the correct position to properly support the fuel string. Changes are also required to the protective interlocks to allow fuelling with flow and reduce risk. A new fuel string supporting shield plug was designed and tested to reduce the risk of endplate cracking that could occur on the irradiated bundle that would have been supported directly by the channel latch. Some operational changes have been incorporated to accommodate this new shield plug. Considerable testing has been carried out on all aspects of fuel handling where fuelling with flow differs from the reference fuelling against flow. (author). 3 figs.

Environmental health scoping study at Bruce Heavy Water Plant

International Nuclear Information System (INIS)

Prior, M.; Mostrom, M.; Coppock, R.; Florence, Z.

1995-10-01

There are concerns that hydrogen sulfide released from the Heavy Water Plant near Kincardine, Ontario may be the cause of the mortalities and morbidities observed in a nearby flock of sheep. The Philosopher's Wool sheep farm is about four kilometres south-southeast of the Bruce Heavy Water Plant. Ontario Hydro, the owner and operator of the Bruce Heavy Water Plant, claims that hydrogen sulphide emissions from the Bruce Heavy Water Plant are within regulatory limits and well below levels that cause harm. Accordingly, the Atomic Energy Control Board commissioned the Alberta Environmental Centre, Alberta Department of Environmental Protection, to develop a scoping study for this environmental health issue. The first objective was to describe a field investigation model to define clearly the environmental health and operation of the sheep farm. The second objective was to describe possible exposure patterns and develop a holistic environmental pathway model. If appropriate, the third study objective was to describe animal models of the actual situation to elucidate specific aspects of the environmental health concerns. It was not the objective of this report to provide a definitive answer to the present environmental health issue. Ontario Hydro provided data to the Alberta Environmental Centre, as di the sheep farmer, the attending veterinarian, the University of Guelph study team, and the Atomic Energy Control Board. A six-tiered strategy of sequential evaluations of the ovine health problem is based on the multiple-response paradigm. It assumes the observed ovine health results are the result of multiple effector events. Each tier constitutes a separate, but inter-related, study. Sequential evaluation and feedback of each tier allow sound scientific judgements and efficient use of resources. (author). 59 refs., 11 tabs., 22 figs

Measurements of Sheath Temperature Profiles in Bruce LVRF Bundles Under Post-Dryout Heat Transfer Conditions in Freon

International Nuclear Information System (INIS)

Guo, Y.; Bullock, D.E.; Pioro, I.L.; Martin, J.

2006-01-01

An experimental program has been completed to study the behaviour of sheath wall temperatures in the Bruce Power Station Low Void Reactivity Fuel (shortened hereafter to Bruce LVRF) bundles under post-dryout (PDO) heat-transfer conditions. The experiment was conducted with an electrically heated simulator of a string of nine Bruce LVRF bundles, installed in the MR-3 Freon heat transfer loop at the Chalk River Laboratories (CRL), Atomic Energy of Canada Limited (AECL). The loop used Freon R-134a as a coolant to simulate typical flow conditions in CANDU R nuclear power stations. The simulator had an axially uniform heat flux profile. Two radial heat flux profiles were tested: a fresh Bruce LVRF profile and a fresh natural uranium (NU) profile. For a given set of flow conditions, the channel power was set above the critical power to achieve dryout, while heater-element wall temperatures were recorded at various overpower levels using sliding thermocouples. The maximum experimental overpower achieved was 64%. For the conditions tested, the results showed that initial dryout occurred at an inner-ring element at low flows and an outer-ring element facing internal subchannels at high flows. Dry-patches (regions of dryout) spread with increasing channel power; maximum wall temperatures were observed at the downstream end of the simulator, and immediately upstream of the mid-bundle spacer plane. In general, maximum wall temperatures were observed at the outer-ring elements facing the internal subchannels. The maximum water-equivalent temperature obtained in the test, at an overpower level of 64%, was significantly below the acceptable maximum temperature, indicating that the integrity of the Bruce LVRF will be maintained at PDO conditions. Therefore, the Bruce LVRF exhibits good PDO heat transfer performance. (authors)

Bruce A units 1 and 2 restart project

International Nuclear Information System (INIS)

Routledge, K.

2006-01-01

This presentation provides an overview of the Bruce A Units 1 and 2 Restart project from the vantage point of the Project Management Contractor (PMC). The presentation will highlight the unique structure of the project, which has been designed to maximize project efficiencies while minimizing the impact to the Bruce Power operational reactors. Efficiency improvements covered in the presentation includes: support services provided to the direct work contractors, radiation protection, worker protection, engineering, field execution, maintenance and facilities. The presentation focusses on the roles of the PMC in helping to ensure the successful outcome of this ambitious reactor refurbishment project. In addition, the Construction Island concept that has been implemented on the project will be presented, with some of the innovative thinking that has gone into its creation. The organization of the PMC and an overview of the project schedule is also presented. AMEC NCL is a privately held consultancy in the Canadian nuclear industry which provides experienced and flexible multi-disciplined resources to support full project management, engineering solutions and safety consultancy services throughout the life cycle of nuclear facilities in Canada, and for customers in related markets in North America and overseas. AMEC NCL is a wholly-owned subsidiary of AMEC plc

AECB staff annual assessment of the Bruce B Nuclear Generating Station for the year 1994

International Nuclear Information System (INIS)

1995-06-01

AECB staff believes Ontario Hydro operated Bruce B safely in 1994. The Bruce B reactors will remain limited to 88% full power until Ontario Hydro is able to demonstrate that it is safe to operate at higher powers. Ontario Hydro's compliance with AECB regulations and the Operating Licence was satisfactory. AECB found no major violations. The station performance was similar to previous years. Radiation doses to workers and the public were well below the legal limits and also remained below Ontario Hydro's internal targets. Worker radiation doses increased slightly but were comparable to previous years. Inspection of pressure tubes and steam generator tubes by Ontario Hydro showed continuing tube degradation. However, we believe that Ontario Hydro made progress in correcting and managing these problems. Ontario Hydro carried out a full-scale fire drill at Bruce B in 1994. AECB witnessed the drill and were pleased to observe a significant improvement in the station's fire-fighting capability. 7 tabs., 4 figs

Integrated inspection programs at Bruce Heavy Water Plant

Energy Technology Data Exchange (ETDEWEB)

Brown, K C [Ontario Hydro, Tiverton, ON (Canada)

1993-12-31

Quality pressure boundary maintenance and an excellent loss prevention record at Bruce Heavy Water Plant are the results of the Material and Inspection Unit`s five inspection programs. Experienced inspectors are responsible for the integrity of the pressure boundary in their own operating area. Inspectors are part of the Technical Section, and along with unit engineering staff, they provide technical input before, during, and after the job. How these programs are completed, and the results achieved, are discussed. 5 figs., 1 appendix.

Integrated inspection programs at Bruce Heavy Water Plant

International Nuclear Information System (INIS)

Brown, K.C.

1992-01-01

Quality pressure boundary maintenance and an excellent loss prevention record at Bruce Heavy Water Plant are the results of the Material and Inspection Unit's five inspection programs. Experienced inspectors are responsible for the integrity of the pressure boundary in their own operating area. Inspectors are part of the Technical Section, and along with unit engineering staff, they provide technical input before, during, and after the job. How these programs are completed, and the results achieved, are discussed. 5 figs., 1 appendix

Structural and metamorphic evolution of the Mid-Late Proterozoic Rayner Complex, Cape Bruce, East Antarctica

International Nuclear Information System (INIS)

Dunkley, D.J.; Clarke, G.L.; White, R.W.

2002-01-01

Granulite to transitional granulite facies gneisses exposed at Cape Bruce, Rayner Complex, East Antarctica, record three main orogenic/magmatic phases: (1) intrusion of c. 1000-980 Ma felsic orthogneisses into Mid-Proterozoic metasediments, contemporary with the development of north-trending reclined to recumbent folds; (2) extensive c. 980-900 Ma felsic magmatism, including equivalents of the Mawson Charnockite, which accompanied the development of upright, east-northeast-trending folds; and (3) ultramylonite zones of uncertain age. The first two phases are known as the Rayner Structrual Episode, the effects of which are similar in rocks to the east of Cape Bruce, at Mawson, and in the northern Prince Charles Mountains. Archaean rocks immediately to the west of Cape Bruce were tectonically reworked during the Rayner Structural Episode. The first orogenic phase is inferred to represent the collision between a wedge-shaped Proterozoic block comprising rocks of the Mawson Coast and Eastern Ghats Province, with the Archaean Napier Complex. The second orogenic phase included a major period of crustal growth through emplacement of the Mawson Charnockite and equivalents. (author). 41 refs., 6 figs., 1 tab

Performance of Bruce natural UO2 fuel irradiated to extended burnups

International Nuclear Information System (INIS)

Zhou, Y.N.; Floyd, M.R.; Ryz, M.A.

1995-11-01

Bruce-type bundles XY, AAH and GF were successfully irradiated in the NRU reactor at Chalk River Laboratories to outer-element burnups of 570-900 MWh/kgU. These bundles were of the Bruce Nuclear Generating Station (NGS)-A 'first-charge' design that contained gas plenums in the outer elements. The maximum outer-element linear powers were 33-37 kW/m. Post-irradiation examination of these bundles confirmed that all the elements were intact. Bundles XY and AAH, irradiated to outer-element burnups of 570-700 MWh/kgU, experienced low fission-gas release (FGR) ( 500 MWh/kgU (equivalent to bundle-average 450 MWh/kgU) when maximum outer-element linear powers are > 50 kW/m. The analysis in this paper suggests that CANDU 37-element fuel can be successfully irradiated (low-FGR/defect-free) to burnups of at least 700 MWh/kgU, provided maximum power do not exceed 40 kW/m. (author). 5 refs., 1 tab., 8 figs

AECB staff review of Bruce NGS 'B' operation for the year 1989

International Nuclear Information System (INIS)

1990-06-01

The operation of the Bruce Nuclear Generating Station 'B' is monitored and licensing requirements are enforced by the Atomic Energy Control Board (AECB), which observes operation of the reactors, conducts audits, witnesses important activities, reviews station documentation and reports, and issue approvals, where appropriate, in accordance with licence conditions. This report records the conclusions of the AECB staff assessment of Bruce NGS 'B' during 1989. In general, the station operated within acceptable safety standards. Quality improvement initiatives started in 1989 should lead to improved station maintenance and operation in coming years. Ontario Hydro still needs to improve the administration of operating memos, deficiency reports and call-ups. Station management must ensure that shift supervisors and reactor first operators operate the station in a conservative manner at all times and put safety interests first when responding to a unit upset. (2 tabs.)

Design of the MiniSLAR system for Bruce A

International Nuclear Information System (INIS)

Gray, M.G.

1995-01-01

Cancellation of Bruce A Retube created the need to perform SLAR on Unit 1. The existing SLAR system cannot reach Unit 1 and alternative systems had limitations. The concept and design of MiniSLAR were driven by the availability of existing components made for Retube. The MiniSLAR concept was developed by a team with members representing operators, technicians, and designers from various departments within Ontario Hydro and GE Canada. Overall project leadership was provided by Bruce A Projects and Modifications Department with assistance from Ontario Hydro Nuclear Technology Services. The responsibility for detailed design was assigned by Ontario Hydro to GE Canada. The detailed design proceeded with continual input and review by the team. The MiniSLAR delivery machine consists of a closure removal ram, a shield plug removal ram and a SLAR tool delivery ram attached to the sliding plate of a horizontal indexing mechanism. The moving plate is constrained by guide rails to a fixed plate and seals against it with o-rings. A snout and clamping mechanism mounts on the front of the fixed plate. The machine mounts atop a work table which provides the various motions required for endfitting engagement. Some operations are performed manually while others are remote and automatic. (author)

The discovery of 260Md and the decay properties of 258Fm, 258m,gMd and 259Md

International Nuclear Information System (INIS)

Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

1986-01-01

We have discovered a new neutron-rich isotope, 260 Md, from 18 O and 22 Ne bombardments of 254 Es. We observed a spontaneous-fission (SF) activity with a half-life of 32 days in electromagnetically separated fractions with mass number 260 from these bombardments and we measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at a total kinetic energy (TKE) of 234 MeV, similar to previous observations for heavy fermium isotopes. Surprisingly, we also observed a smaller symmetric component with a TKE of 195 MeV. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of 260 Md or from 260 Fm which would arise from electron-capture (EC) decay of 260 Md. We have eliminated the possible β - decay of 260 Md by measuring β - -SF time correlations for the decay of 260 Md and we plan to determine whether 260 Md decays by EC by measuring time correlations between fermium X-rays and SF events. We also measured various properties of the heavy fermium and mendelevium isotopes and obtained 1. more accurate cross-sections for the neutron-rich mendelevium isotopes which we use to predict the production rates of yet undiscovered nuclides, 2. improved half-life measurements for 258m,g Md and 259 Md, 3. confirmation of the EC decay of 258m Md by measurement of the fermium X-rays preceding the SF decay of 258 Fm and 4. very substantially improved mass and TKE distributions for the SF decay of 258 Fm and 259 Md. (orig.)

An appreciation of Bruce and Young's (1986) serial stage model of face naming after 25 years.

Science.gov (United States)

Hanley, J Richard

2011-11-01

The current status of Bruce and Young's (1986) serial model of face naming is discussed 25 years after its original publication. In the first part of the paper, evidence for and against the serial model is reviewed. It is argued that there is no compelling reason why we should abandon Bruce and Young's claim that recall of a name is contingent upon prior retrieval of semantic information about the person. The current status of the claim that people's names are more difficult to recall than the names of objects is then evaluated. Finally, an account of the anatomical location in the brain of Bruce and Young's three processing stages (face familiarity, retrieval of semantic information, retrieval of names) is suggested. In particular, there is evidence that biographical knowledge about familiar people is stored in the right anterior temporal lobes (ATL) and that the left temporal pole (TP) is heavily involved in retrieval of the names of familiar people. The issue of whether these brain areas play a similar role in object processing is also discussed. ©2011 The British Psychological Society.

Flux distribution measurements in the Bruce A unit 1 reactor

International Nuclear Information System (INIS)

Okazaki, A.; Kettner, D.A.; Mohindra, V.K.

1977-07-01

Flux distribution measurements were made by copper wire activation during low power commissioning of the unit 1 reactor of the Bruce A generating station. The distribution was measured along one diameter near the axial and horizontal midplanes of the reactor core. The activity distribution along the copper wire was measured by wire scanners with NaI detectors. The experiments were made for five configurations of reactivity control mechanisms. (author)

Review of Bruce A reactor regulating system software

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-01

Each of the four reactor units at the Ontario Hydro Bruce A Nuclear Generating Station is controlled by the Reactor Regulating System (RRS) software running on digital computers. This research report presents an assessment of the quality and reliability of the RRS software based on a review of the RRS design documentation, an analysis of certain significant Event Reports (SERs), and an examination of selected software changes. We found that the RRS software requirements (i.e., what the software should do) were never clearly documented, and that design documents, which should describe how the requirements are implemented, are incomplete and inaccurate. Some RRS-related SERs (i.e., reports on unexpected incidents relating to the reactor control) implied that there were faults in the RRS, or that RRS changes should be made to help prevent certain unexpected events. The follow-up investigations were generally poorly documented, and so it could not usually be determined that problems were properly resolved. The Bruce A software change control procedures require improvement. For the software changes examined, there was insufficient evidence provided by Ontario Hydro that the required procedures regarding change approval, independent review, documentation updates, and testing were followed. Ontario Hydro relies on the expertise of their technical staff to modify the RRS software correctly; they have confidence in the software code itself, even if the documentation is not up-to-date. Ontario Hydro did not produce the documentation required for an independent formal assessment of the reliability of the RRS. (author). 37 refs., 3 figs.

Review of Bruce A reactor regulating system software

International Nuclear Information System (INIS)

1995-12-01

Each of the four reactor units at the Ontario Hydro Bruce A Nuclear Generating Station is controlled by the Reactor Regulating System (RRS) software running on digital computers. This research report presents an assessment of the quality and reliability of the RRS software based on a review of the RRS design documentation, an analysis of certain significant Event Reports (SERs), and an examination of selected software changes. We found that the RRS software requirements (i.e., what the software should do) were never clearly documented, and that design documents, which should describe how the requirements are implemented, are incomplete and inaccurate. Some RRS-related SERs (i.e., reports on unexpected incidents relating to the reactor control) implied that there were faults in the RRS, or that RRS changes should be made to help prevent certain unexpected events. The follow-up investigations were generally poorly documented, and so it could not usually be determined that problems were properly resolved. The Bruce A software change control procedures require improvement. For the software changes examined, there was insufficient evidence provided by Ontario Hydro that the required procedures regarding change approval, independent review, documentation updates, and testing were followed. Ontario Hydro relies on the expertise of their technical staff to modify the RRS software correctly; they have confidence in the software code itself, even if the documentation is not up-to-date. Ontario Hydro did not produce the documentation required for an independent formal assessment of the reliability of the RRS. (author). 37 refs., 3 figs

Md Naimuddin

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics. Md Naimuddin. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1255-1258 Poster Presentations. Model unspecific search for new physics in collision at s = 7 TeV · Shivali Malhotra Md Naimuddin Thomas Hebbeker Arnd Meyer ...

Estimating the number of latent cracks in pressure tube joints at Bruce unit 2

International Nuclear Information System (INIS)

Schwarz, C.J.

1983-10-01

A model was built to estimate the number of hydride cracks which might have arisen in the rolled joints of Bruce unit 2 prior to the stress relieving operation. The model estimated that about 100 such cracks might exist. Since this estimate is based on experiments that were thermally cycled and since cycling did not occur in Bruce, prior to stress relieving the actual number is expected to be substantially lower. A sensitivity analysis of the model showed that it is sensitive to the assumptions of stress levels, probability of initiation and distribution of initiation time. A better estimate could be made if more data were available on these parameters under realistic conditions. Therefore, the recommendation is made to collect more information about these factors under realistic conditions

Apple fruit acidity is genetically diversified by natural variations in three hierarchical epistatic genes MdSAUR37, MdPP2CH and MdALMTII.

Science.gov (United States)

Jia, Dongjie; Shen, Fei; Wang, Yi; Wu, Ting; Xu, Xuefeng; Zhang, Xinzhong; Han, Zhenhai

2018-05-11

Many efforts have been made to map quantitative trait loci (QTLs) to facilitate practical marker-assisted selection (MAS) in plants. In the present study, we identified four genome-wide major QTLs responsible for apple fruit acidity by MapQTL and BSA-seq analyses using two independent pedigree-based populations. Candidate genes were screened in major QTL regions, and three functional gene markers, including a non-synonymous A/G single nucleotide polymorphism (SNP) in the coding region of MdPP2CH, a 36-bp insertion in the promoter of MdSAUR37, and a previously reported SNP in MdALMTII, were validated to influence the malate content of apple fruits. In addition, MdPP2CH inactivated three vacuolar H + -ATPases (MdVHA-A3, MdVHA-B2 and MdVHA-D2) and one aluminium-activated malate transporter (MdALMTII) via dephosphorylation and negatively influenced fruit malate accumulation. The dephosphotase activity of MdPP2CH was suppressed by MdSAUR37, which implied a higher hierarchy of genetic interaction. Therefore, the MdSAUR37/MdPP2CH/MdALMTII chain cascaded hierarchical epistatic genetic effects to precisely determine apple fruit malate content. An A/G SNP (-1010) on MdMYB44 promoter region from a major QTL (qtl08.1) was closely associated with fruit malate content. The predicted phenotype values (PPVs) were estimated using the tentative genotype values of the gene markers, and the PPVs were significantly correlated with the observed phenotype values. Our findings provide an insight into plant genome-based selection in apples and will aid in conducting research to understand the physiological fundamentals of quantitative genetics. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Exercise capacity in Dutch children : New reference values for the Bruce treadmill protocol

NARCIS (Netherlands)

M.H.M. van der Cammen-van Zijp (Monique); H.J.G. van den Berg-Emons (Rita); S.P. Willemsen (Sten); H.J. Stam (Henk); D. Tibboel (Dick); H. IJsselstijn (Hanneke)

2010-01-01

textabstractThe Bruce treadmill protocol is suitable for children 4 years of age and older. Dutch reference values were established in 1987. We considered that children's exercise capacity has deteriorated due to changes in physical activity patterns and eating habits. We determined new reference

Injector MD Days 2017

CERN Document Server

Rumolo, G

2017-01-01

The Injector Machine Development (MD) days 2017 were held on 23-24 March, 2017, at CERN with thefollowing main goals:Give a chance to the MD users to present their results and show the relevant progress made in 2016 onseveral fronts.Provide the MD users and the Operation (OP) crews with a general overview on the outcome and theimpact of all ongoing MD activities.Identify the open questions and consequently define - with priorities - a list of machine studies in theinjectors for 2017 (covering the operational beams, LHC Injectors Upgrade, High Luminosity LHC,Physics Beyond Colliders, other projects).Create the opportunity to collect and document the highlights of the 2016 MDs and define the perspectivesfor 2017.Discuss how to make best use of the MD time, in particular let the main MD user express their wishesand see whether/how OP teams can contribute to their fulfilment.

AECB staff annual report of Bruce A NGS for the year 1991

International Nuclear Information System (INIS)

1992-11-01

In this report on Bruce A operations during 1991, AECB staff itemizes non-compliances with the operating licence. Non of the violations that occurred at Bruce A resulted in any significant threat to public safety or well-being. There were no exposures of workers to radiation in excess of the regulatory requirements; however, there have been instances of uncontrolled contaminated areas and spread of contamination in the station. Releases of radioactive material to the environment were much below target. The performance of the four special safety systems has been good, with the exception of shutdown system number two on Unit 3. A review of significant event reports and their causes has revealed an apparent lack of a system by which operations and maintenance work is verified as having been carried out correctly. There is a large backlog of maintenance work. Initiatives have been taken to correct this problem. Two important safety issues are discussed in detail. These are the chronic problem of leaking boiler tubes, and the potentially serious problem of fret marks on pressure tubes caused by abnormal fuel support. (Author)

Impact of bundle deformation on CHF: ASSERT-PV assessment of extended burnup Bruce B bundle G85159W

International Nuclear Information System (INIS)

Rao, Y.F.; Manzer, A.M.

2005-01-01

This paper presents a subchannel thermalhydraulic analysis of the effect on critical heat flux (CHF) of bundle deformation such as element bow and diametral creep. The bundle geometry is based on the post-irradiation examination (PIE) data of a single bundle from the Bruce B Nuclear Generating Station, Bruce B bundle G85159W, which was irradiated for more than two years in the core during reactor commissioning. The subchannel code ASSERT-PV IST is used to assess changes in CHF and dryout power due to bundle deformation, compared to the reference, undeformed bundle. (author)

Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

Science.gov (United States)

Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

2017-07-11

Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

Cryptanalysis of MD2

DEFF Research Database (Denmark)

Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

2010-01-01

This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

Identification of 253Md

International Nuclear Information System (INIS)

Kadkhodayan, B.; Czerwinski, K.R.; Kreek, S.A.; Hannink, N.J.; Gregorich, K.E.; Lee, D.M.; Nurmia, M.J.; Hoffman, D.C.; Hall, H.L.

1992-01-01

We have measured the half-life and production cross section of the new isotope 253 Md, produced via the 243 Am( 13 C,3n) reaction. Isolation of Md from other activities was accomplished using elution with ammonium α-hydroxyisobutyrate from a cation exchange resin column. Experiments were performed with different irradiation time intervals, but the chemical separation always began and ended at exactly the same length of time after the end of irradiation. All separations with the same irradation lengths were combined and analyzed for growth and decay of the 3.0-d 253 Fm daughter and 20.47-d 253 Es, granddaugther of 253 Md. The amount of 253 Es in each fraction depends on the length of each irradiation and the 253 Md half-life. An increase in the length of irradiation will cause a corresponding increase in the amount of the new isotope 253 Md and hence, in the amount of 253 Es produced, provided the length of irradiations are not very long compared to the half-life of 253 Md. In this way, the Md half-life was estimated to be about 6 minutes with a production cross section of the order of 50 nb. (orig.)

Bruce Unit 2 lay-up engineering assessment

International Nuclear Information System (INIS)

Iley, D.

1995-01-01

The overall lay-up program initiated as a result of the strategic decision to shut down Bruce A unit 2 is briefly described as an introduction to the engineering assessment of the unit 2 systems. The assessment has identified the need to prepare 67 system and 9 equipment lay-up specifications. A summary of the selected system specifications is described. A complete summary and the specifications and the status of unit 2 systems and equipment required to support lay-up and/or the other three operating units is available on request due to the volume of the information. Some logistical details of the lay-up implementation plans, results, and problems to date demonstrate the complexity of the lay-up requirements for a nuclear unit in a multi-unit CANDU station. (author)

Regional and site geological frameworks : proposed Deep Geologic Repository, Bruce County, Ontario

Energy Technology Data Exchange (ETDEWEB)

Raven, K.; Sterling, S.; Gaines, S.; Wigston, A. [Intera Engineering Ltd., Ottawa, ON (Canada); Frizzell, R. [Nuclear Waste Management Organization, Toronto, ON (Canada)

2009-07-01

The Nuclear Waste Management Organization is conducting geoscientific studies on behalf of Ontario Power Generation into the proposed development of a Deep Geologic Repository (DGR) for low and intermediate level radioactive waste (L and ILW) at the Bruce site, near Tiverton, Ontario. This paper presented a regional geological framework for the site that was based on a review of regional drilling; structural geology; paleozoic stratigraphy and sedimentology; a 3D geological framework model; a DGR geological site characterization model; bedrock stratigraphy and marker beds; natural fracture frequency data; and formation predictability. The studies have shown that the depth, thickness, orientation and rock quality of the 34 rock formations, members or units that comprise the 840 m thick Paleozoic bedrock sequence at the Bruce site are very uniform and predictable over distances of several kilometres. The proposed DGR will be constructed as an engineered facility comprising a series of underground emplacement rooms at a depth of 680 metres below ground within argillaceous limestones. The geoscientific studies are meant to provide a basis for the development of descriptive geological, hydrogeological and geomechanical models of the DGR site that will facilitate environmental and safety assessments. 11 refs., 3 tabs., 9 figs.

Experience of oil in CANDU moderator during A831 planned outage at Bruce Power

International Nuclear Information System (INIS)

Ma, G.; Nashiem, R.; Matheson, S.; Stuart, C.; Roberts, J.G.

2011-01-01

In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

Experience of oil in CANDU® moderator during A831 planned outage at Bruce Power

International Nuclear Information System (INIS)

Ma, G.; Nashiem, R.; Matheson, S.; Stuart, C.; Roberts, J.G.

2010-01-01

In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU® reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

Experience of oil in CANDU® moderator during A831 planned outage at Bruce Power

Energy Technology Data Exchange (ETDEWEB)

Ma, G.; Nashiem, R.; Matheson, S. [Bruce Power, Tiverton, Ontario (Canada); Stuart, C. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Roberts, J.G. [CANTECH Associates Ltd., Burlington, Ontario (Canada)

2010-07-01

In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU® reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

Experience of oil in CANDU moderator during A831 planned outage at Bruce Power

Energy Technology Data Exchange (ETDEWEB)

Ma, G.; Nashiem, R.; Matheson, S. [Bruce Power, Tiverton, Ontario (Canada); Stuart, C. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Roberts, J.G. [CANTECH Associates Ltd., Burlington, Ontario (Canada)

2011-03-15

In their address to the Nuclear Plant Chemistry Conference 2009, Bruce Power staff will describe the effects of oil ingress to the moderator of a CANDU reactor. During the A831 planned outage of Bruce Power Unit 3, an incident of oil ingress into moderator was discovered on Oct 17, 2008. An investigation identified the cause of the oil ingress. Atomic Energy of Canada Ltd. (AECL) assessed operability of the reactor with the oil present and made recommendations with respect to the effect on unit start-up with oil present. The principal concern was the radiolytic generation of deuterium from the breakdown of the oil in-core. Various challenges were presented during start-up which were overcome via innovative approaches. The subsequent actions and consequential effects on moderator chemistry are discussed in this paper. Examination of the plant chemistry data revealed some interesting aspects of moderator system chemistry under upset conditions which will also be presented. (author)

Kuldlõvid Louise Bourgeois'le, Bruce Naumanile ja Itaalia paviljonile / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

1999-01-01

Veneetsia 48. rahvusvahelise kunstibiennaali preemiasaajad, premeeritud tööd, korralduskomitee ja žürii koosseis. Kuldlõvid: Louise Bourgeois, Bruce Nauman, Itaalia paviljon (Monica Bonvicini, Bruna Esposito, Luisa Lambri, Paola Pivi, Grazia Toderi ühisprojekt); kolm rahvusvahelist preemiat: Doug Aitken, Cai Gou-Qiang, Shirin Neshat; žürii tõstis esile: Georges Abeagbo, Eija-Liisa Ahtila, Katarzyna Kozura ? (Kozyra), Lee Bul; UNESCO preemia: Ghada Amer

Fuel bundle to pressure tube fretting in Bruce and Darlington

Energy Technology Data Exchange (ETDEWEB)

Norsworthy, A G; Ditschun, A [Atomic Energy of Canada Ltd., Mississauga, ON (Canada)

1996-12-31

As the fuel channel elongates due to creep, the fuel string moves relative to the inlet until the fuel pads at the inboard end eventually separate from the spacer sleeve, and the fuel resides on the burnish mark of the pressure tube. The bundle is then supported in a fashion which contributes to increased levels of vibration. Those pads which (due to geometric variation) have contact loads with the pressure tube within a certain range, vibrate, and cause significant fretting on the burnish mark, and further along at the midplane of the bundle. Inspection of the pressure tubes in Bruce A, Bruce B, and Darlington has revealed fret damage up to 0.55 mm at the burnish mark and slightly lower than this at the inlet bundle midplane. To date, all fret marks have been dealt with successfully without the need for tube replacement, but a program of work has been initiated to understand the mechanism and reduce the fretting. Such understanding is necessary to guide future design changes to the fuel bundle, to guide future inspection programs, to guide maintenance programs, and for longer term strategic planning. This paper discusses how the understanding of fretting has evolved and outlines a current hypothesis for the mechanism of fretting. The role of bundle geometry, excitation forces, and reactor conditions are reviewed, along with options under consideration to mitigate damage. (author). 4 refs., 2 tabs., 13 figs.

Fuel bundle to pressure tube fretting in Bruce and Darlington

International Nuclear Information System (INIS)

Norsworthy, A.G.; Ditschun, A.

1995-01-01

As the fuel channel elongates due to creep, the fuel string moves relative to the inlet until the fuel pads at the inboard end eventually separate from the spacer sleeve, and the fuel resides on the burnish mark of the pressure tube. The bundle is then supported in a fashion which contributes to increased levels of vibration. Those pads which (due to geometric variation) have contact loads with the pressure tube within a certain range, vibrate, and cause significant fretting on the burnish mark, and further along at the midplane of the bundle. Inspection of the pressure tubes in Bruce A, Bruce B, and Darlington has revealed fret damage up to 0.55 mm at the burnish mark and slightly lower than this at the inlet bundle midplane. To date, all fret marks have been dealt with successfully without the need for tube replacement, but a program of work has been initiated to understand the mechanism and reduce the fretting. Such understanding is necessary to guide future design changes to the fuel bundle, to guide future inspection programs, to guide maintenance programs, and for longer term strategic planning. This paper discusses how the understanding of fretting has evolved and outlines a current hypothesis for the mechanism of fretting. The role of bundle geometry, excitation forces, and reactor conditions are reviewed, along with options under consideration to mitigate damage. (author). 4 refs., 2 tabs., 13 figs

After reliability centred maintenance. Preventive maintenance living program implementation at Bruce Power

International Nuclear Information System (INIS)

Harazim, Michael L.; Ferguson, Brian J.

2003-01-01

Industrial preventive maintenance (PM) programs represent a large part of plant O and M costs. PM Optimization (PMO) projects represent an effective mechanism for identifying unnecessary PM, extending PM intervals and infusing predictive maintenance (PdM) methods. However, once optimized, what process prevents the PM program from returning to a state of disarray? This is the function of a PM living program (PMLP). In 1997, an independent performance assessment identified concerns with the applicability and effectiveness of all Ontario Power Generation, Inc. (OPGI) PM programs. In response, OPGI instituted an Integrated Maintenance Program (IMP) including Reliability Centred Maintenance (RCM) and a PMLP. It should be noted that the PMLP was developed for the 3 OPGI nuclear Sites (i.e. Bruce, Pickering, and Darlington). Effective 1 May 2001, the Bruce Site has been leased to a group of investors lead by British Energy. This paper is written in historical context and therefore refers to the Bruce Site as part of OPGI. The PMLP is made up of five elements: 1) process control, 2) change control, 3) worker feedback, 4) program performance metrics, and 5) deferral module. A PMLP software tool, originally applied to Duke Energy nuclear plants, was enhanced and customized specifically for the OPGI PMLP, and then implemented at all three of OPGI's nuclear sites. The objective of the OPGI PMLP was to: Provide processes/procedures for continual optimization of all site PM tasks, Ensure effective and timely revision of PM tasks in the work management system, Ensure PM tasks remain applicable/effective at all times, Maintain and enhance PM consistency on a component, system and Site basis, Ensure that new predictive maintenance techniques are applied and integrated with the PM program, Ensure that mandated PM tasks are identified and executed, Provide a mechanism for craft feedback, Meet regulatory requirements for PM program effectiveness, and Provide PM task deferral

Production of yellow-green fluorescent pigment by Pseudomonas fluorescens

Directory of Open Access Journals (Sweden)

Gildo Almeida da Silva

2006-05-01

Full Text Available A medium was prepared from brewery waste yeast with and without mineral salts to study growth and yellow-green fluorescent pigment production (YGFP by Pseudomonas fluorescens. The King's medium used for detection of siderophore production were expressively weaker inductors of YGFP formation when compared to FYE medium. Although FYE and CYE could be used for growth of P. fluorescens, only FYE was an attractive medium for detection of YGFP strain producers.Diversos microrganismos secretam substâncias com alta afinidade por ferro. Estas moléculas, sideróforos, transportam ferro para o interior das células. Como a produção destas moléculas depende da composição do meio, foi avaliada a influência do extrato de levedura (FYE, proveniente de resíduo de cervejaria, com e sem adição de sais minerais, sobre o crescimento de Pseudomonas fluorescens e sobre a formação de pigmento fluorescente verde-amarelado (YGFP. Observou-se que (i FYE com sacarose (G7 e o extrato de levedura comercial (CYE possuem um pico bem definido próximo a 260 nm; (ii FYE, mas não CYE, promove alta formação de YGFP. Os meios de King's, usados para detectar a formação de sideróforo, se comportaram como indutores expressivamente mais fracos de YGFP que o meio FYE. Embora FYE e CYE possam ser usados para o crescimento de P. fluorescens, apenas FYE pode ser usado como meio para a detecção de linhagens formadoras de YGFP.

Review of the reliability of Bruce 'B' RRS dual computer system

International Nuclear Information System (INIS)

Arsenault, J.E.; Manship, R.A.; Levan, D.G.

1995-07-01

The review presents an analysis of the Bruce 'B' Reactor Regulating System (RRS) Digital Control Computer (DCC) system, based on system documentation, significant event reports (SERs), question sets, and a site visit. The intent is to evaluate the reliability of the RRS DCC and to identify the possible scenarios that could lead to a serious process failure. The evaluation is based on three relatively independent analyses, which are integrated and presented in the form of Conclusions and Recommendations

Power raise through improved reactor inlet header temperature measurement at Bruce A Nuclear Generation Station

International Nuclear Information System (INIS)

Basu, S.; Bruggemn, D.

1997-01-01

Reactor Inlet Header (RIH) temperature has become a factor limiting the performance of the Ontario Hydro Bruce A units. Specifically, the RIH temperature is one of several parameters that is preventing the Bruce A units from returning to 94% power operation. RIH temperature is one of several parameters which affect the critical heat flux in the reactor channel, and hence the integrity of the fuel. Ideally, RIH temperature should be lowered, but this cannot be done without improving the heat transfer performance of the boilers and feedwater pre-heaters. Unfortunately, the physical performance of the boilers and pre-heaters has decayed and continues to decay over time and as a result the RIH temperature has been rising and approaching its defined limit. With an understanding of the current RIH temperature measurement loop and methods available to improve it, a solution to reduce the measurement uncertainty is presented

Chemistry control at Bruce NGS 'B' from constructed to commercial operation

International Nuclear Information System (INIS)

Roberts, J.G.

1987-01-01

Pre-operational storage chemistry and flushing of the secondary side is described. The approach devised for Bruce NGS 'B' Unit 6 was unique for an Ontario Hydro Nuclear Unit. The significance of the improved Construction installation and Quality Assurance procedures, combined with those of Operations is identified. Secondary side chemistry during both commissioning and later operation is reported. It will be shown that the application of ALARA (As Low As is Reasonably Achievable) concept has resulted in tighter chemical specifications being met

R. Bruce Merrifield and Solid-Phase Peptide Synthesis: A Historical Assessment

Energy Technology Data Exchange (ETDEWEB)

Mitchell, A R

2007-12-04

Bruce Merrifield, trained as a biochemist, had to address three major challenges related to the development and acceptance of solid-phase peptide synthesis (SPPS). The challenges were (1) to reduce the concept of peptide synthesis on a insoluble support to practice, (2) overcome the resistance of synthetic chemists to this novel approach, and (3) establish that a biochemist had the scientific credentials to effect the proposed revolutionary change in chemical synthesis. How these challenges were met is discussed in this article.

Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

Science.gov (United States)

Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

2016-12-01

Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

Steam generator leak detection at Bruce A Unit 1

International Nuclear Information System (INIS)

Maynard, K.J.; McInnes, D.E.; Singh, V.P.

1997-01-01

A new steam generator leak detection system was recently developed and utilized at Bruce A. The equipment is based on standard helium leak detection, with the addition of moisture detection and several other capability improvements. All but 1% of the Unit 1 Boiler 03 tubesheet was inspected, using a sniffer probe which inspected tubes seven at a time and followed by individual tube inspections. The leak search period was completed in approximately 24 hours, following a prerequisite period of several days. No helium leak indications were found anywhere on the boiler. A single water leak indication was found, which was subsequently confirmed as a through-wall defect by eddy current inspection. (author)

Fighting with Reality: Considering Mark Johnson's Pragmatic Realism through Bruce Lee's Jeet Kune Do Method

Science.gov (United States)

Miller, Alexander David

2015-01-01

This dissertation considers the supportive and complementary relation between Mark Johnson's embodied realism and Bruce Lee's Jeet Kune Do as a philosophical practice. In exploring this relationship, the emphasis on one's embodiment condition and its relationship with metaphor and self-expression are the primary focus. First, this work involves…

75 FR 47203 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes Equipped...

Science.gov (United States)

2010-08-05

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...

Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

Science.gov (United States)

Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

2017-01-01

MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple ( Malus × domestica ). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1 , and MdPR10-2 . In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26 . In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

Steam generator cleaning campaigns at Bruce A: 1993-1996

International Nuclear Information System (INIS)

Puzzuoli, F.V.; Leinonen, P.J.; Lowe, G.A.

1997-01-01

Boiler chemical cleaning (BOCC) and high-pressure water lancing operations were performed during the Bruce A 1993 Unit 3, 1994 Unit 3, 1995 Unit 1 and 1996 Unit 3 outages to remove secondary side deposits. High-pressure water lancing focused on three boiler areas: tube support plates, to remove broached hole deposits, hot leg U-bend supports to dislodge deposits contributing to boiler tube stress corrosion cracking and tube sheets with the aim of removing accumulated sludge piles and post BOCC insoluble residues. The chemical cleaning processes applied were modified versions of the one developed by the Electric Power Research Institute/Steam Generator Owners Group. During these BOCC operations, corrosion for several key boiler materials was monitored and was well below the specified allowances

75 FR 80744 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

Science.gov (United States)

2010-12-23

...-1203; Directorate Identifier 2010-NM-168-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87) and MD-88...

mdFoam+: Advanced molecular dynamics in OpenFOAM

Science.gov (United States)

Longshaw, S. M.; Borg, M. K.; Ramisetti, S. B.; Zhang, J.; Lockerby, D. A.; Emerson, D. R.; Reese, J. M.

2018-03-01

This paper introduces mdFoam+, which is an MPI parallelised molecular dynamics (MD) solver implemented entirely within the OpenFOAM software framework. It is open-source and released under the same GNU General Public License (GPL) as OpenFOAM. The source code is released as a publicly open software repository that includes detailed documentation and tutorial cases. Since mdFoam+ is designed entirely within the OpenFOAM C++ object-oriented framework, it inherits a number of key features. The code is designed for extensibility and flexibility, so it is aimed first and foremost as an MD research tool, in which new models and test cases can be developed and tested rapidly. Implementing mdFoam+ in OpenFOAM also enables easier development of hybrid methods that couple MD with continuum-based solvers. Setting up MD cases follows the standard OpenFOAM format, as mdFoam+ also relies upon the OpenFOAM dictionary-based directory structure. This ensures that useful pre- and post-processing capabilities provided by OpenFOAM remain available even though the fully Lagrangian nature of an MD simulation is not typical of most OpenFOAM applications. Results show that mdFoam+ compares well to another well-known MD code (e.g. LAMMPS) in terms of benchmark problems, although it also has additional functionality that does not exist in other open-source MD codes.

Uncertainties in gas dispersion at the Bruce heavy water plant

International Nuclear Information System (INIS)

Alp, E.; Ciccone, A.

1995-07-01

There have been concerns regarding the uncertainties in atmospheric dispersion of gases released from the Bruce Heavy Water Plant (BHWP). The concern arises due to the toxic nature of H 2 S, and its combustion product SO 2 . In this study, factors that contribute to the uncertainties, such as the effect of the shoreline setting, the potentially heavy gas nature of H 2 S releases, and concentration fluctuations, have been investigated. The basic physics of each of these issues has been described along with fundamental modelling principles. Recommendations have been provided on available computer models that would be suitable for modelling gas dispersion in the vicinity of the BHWP. (author). 96 refs., 4 tabs., 25 figs

Bruce unit 1 moderator to end shield cooling leak repairs

Energy Technology Data Exchange (ETDEWEB)

Boucher, P; Ashton, A [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1996-12-31

In October 1994, a leak developed between the heavy water Moderator System and the light water End Shield Cooling System at Ontario Hydro`s Bruce A Generating Station Unit 1. The interface between these two systems consists of numerous reactor components all within the reactor vessel. This paper describes the initial discovery and determination of the leak source. The techniques used to pinpoint the leak location are described. The repair strategies and details are outlined. Flushing and refilling of the Moderator system are discussed. The current status of the Unit 1 End Shield Cooling System is given with possible remedial measures for clean-up. Recommendations and observations are provided for future references. (author). 7 figs.

Uncertainties in gas dispersion at the Bruce heavy water plant

Energy Technology Data Exchange (ETDEWEB)

Alp, E; Ciccone, A [Concord Environmental Corp., Downsview, ON (Canada)

1995-07-01

There have been concerns regarding the uncertainties in atmospheric dispersion of gases released from the Bruce Heavy Water Plant (BHWP). The concern arises due to the toxic nature of H{sub 2}S, and its combustion product SO{sub 2}. In this study, factors that contribute to the uncertainties, such as the effect of the shoreline setting, the potentially heavy gas nature of H{sub 2}S releases, and concentration fluctuations, have been investigated. The basic physics of each of these issues has been described along with fundamental modelling principles. Recommendations have been provided on available computer models that would be suitable for modelling gas dispersion in the vicinity of the BHWP. (author). 96 refs., 4 tabs., 25 figs.

Coffee Cups, Canoes, Airplanes and the Lived Experience: Reflections on the Works of Bertram (Chip) Bruce

Science.gov (United States)

Haythornthwaite, Caroline

2014-01-01

A career spent in research, teaching, and engagement with community entails a lifetime of assemblage of meaning from people, resources, technologies and experience. In his work, Bertram (Chip) Bruce has long engaged with how we create such an assemblage of meaning from our formal and found learning, and from the "lived experience" of…

Development of restriction enzyme analyses to distinguish winter moth from bruce spanworm and hybrids between them

Science.gov (United States)

Marinko Sremac; Joseph Elkinton; Adam. Porter

2011-01-01

Elkinton et. al. recently completed a survey of northeastern North America for the newly invasive winter moth, Operophtera brumata L. The survey used traps baited with the winter moth pheromone, which consists of a single compound also used by Bruce spanworm, O. bruceata (Hulst), the North American congener of winter moth. Our...

Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

Science.gov (United States)

Goldberg, Charles; Insel, Paul A

2013-06-01

Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

Adapting Scott and Bruce's General Decision-Making Style Inventory to Patient Decision Making in Provider Choice.

Science.gov (United States)

Fischer, Sophia; Soyez, Katja; Gurtner, Sebastian

2015-05-01

Research testing the concept of decision-making styles in specific contexts such as health care-related choices is missing. Therefore, we examine the contextuality of Scott and Bruce's (1995) General Decision-Making Style Inventory with respect to patient choice situations. Scott and Bruce's scale was adapted for use as a patient decision-making style inventory. In total, 388 German patients who underwent elective joint surgery responded to a questionnaire about their provider choice. Confirmatory factor analyses within 2 independent samples assessed factorial structure, reliability, and validity of the scale. The final 4-dimensional, 13-item patient decision-making style inventory showed satisfactory psychometric properties. Data analyses supported reliability and construct validity. Besides the intuitive, dependent, and avoidant style, a new subdimension, called "comparative" decision-making style, emerged that originated from the rational dimension of the general model. This research provides evidence for the contextuality of decision-making style to specific choice situations. Using a limited set of indicators, this report proposes the patient decision-making style inventory as valid and feasible tool to assess patients' decision propensities. © The Author(s) 2015.

First thoughts on MD priorities for 2012

CERN Document Server

Zimmermann, F; Assmann, R

2012-01-01

In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

Expected changes in competency assurance at Bruce Power over next decade

Energy Technology Data Exchange (ETDEWEB)

Horton, C., E-mail: chip.horton@brucepower.com [Bruce Power, Tiverton, Ontario (Canada)

2013-07-01

There will be ten expected changes in competency assurance at Bruce Power over next decade. These changes are: outage worker supplemental staff change; entry level power worker union staff; self-paced process & software training; electronic confirmation of qualifications; JIT built into processes for low frequency tasks; more terminal objective back to fundamentals vs fundamentals build to terminal objective instructional design; more learning by practice / doing in a safe environment; SAT emphasis move from analysis, design & development to evaluation & maintenance of task lists (clearly tied to working rights); more formal tacit knowledge capture programs, systematic movement of knowledge from tacit to explicit; more breadth & depth training driven by demographic changes.

Expected changes in competency assurance at Bruce Power over next decade

International Nuclear Information System (INIS)

Horton, C.

2013-01-01

There will be ten expected changes in competency assurance at Bruce Power over next decade. These changes are: outage worker supplemental staff change; entry level power worker union staff; self-paced process & software training; electronic confirmation of qualifications; JIT built into processes for low frequency tasks; more terminal objective back to fundamentals vs fundamentals build to terminal objective instructional design; more learning by practice / doing in a safe environment; SAT emphasis move from analysis, design & development to evaluation & maintenance of task lists (clearly tied to working rights); more formal tacit knowledge capture programs, systematic movement of knowledge from tacit to explicit; more breadth & depth training driven by demographic changes.

Development and implementation of the heavy water program at Bruce Power

International Nuclear Information System (INIS)

Davloor, R.; Bourassa, C.

2014-01-01

Bruce Power operates 8 pressurized heavy water reactor units requiring more than 6000 mega grams (Mg) of heavy water. A Heavy Water Management Program that has been developed to administer this asset over the past 3 years. Through a corporate management system the Program provides governance, oversight and support to the stations. It is implemented through organizational structure, program and procedure documents and an information management system that provides benchmarked metrics, business intelligence and analytics for decision making and prediction. The program drives initiatives such as major maintenance activities, capital programs, detritiation strategies and ensures heavy water systems readiness for outages and rehabilitation of units. (author)

Development and implementation of the heavy water program at Bruce Power

Energy Technology Data Exchange (ETDEWEB)

Davloor, R.; Bourassa, C., E-mail: ram.davloor@brucepower.com, E-mail: carl.bourassa@brucepower.com [Bruce Power, Tiverton, ON (Canada)

2014-07-01

Bruce Power operates 8 pressurized heavy water reactor units requiring more than 6000 mega grams (Mg) of heavy water. A Heavy Water Management Program that has been developed to administer this asset over the past 3 years. Through a corporate management system the Program provides governance, oversight and support to the stations. It is implemented through organizational structure, program and procedure documents and an information management system that provides benchmarked metrics, business intelligence and analytics for decision making and prediction. The program drives initiatives such as major maintenance activities, capital programs, detritiation strategies and ensures heavy water systems readiness for outages and rehabilitation of units. (author)

Nuclear process steam for industry: potential for the development of an Industrial Energy Park adjacent to the Bruce Nuclear Power Development

Energy Technology Data Exchange (ETDEWEB)

Seddon, W A

1981-11-01

This report summarizes the results of an industrial survey jointly funded by the Bruce County Council, the Ontario Energy Corporation, Atomic Energy of Canada Limited and conducted with the cooperation of Ontario Hydro and the Ontario Ministry of Industry and Tourism. The objective of the study was to identify and assess the future needs and interest of energy-intensive industries in the concept of an Industrial Energy Park adjacent tof the Bruce Nuclear Power Development. The proposed Energy Park would capitalize on the infrastructure of the existing CANDU reactors and Ontario Hydro's proven and unique capability to produce steam, as well as electricity, at a cost currently about half that from a comparable coal-fired station.

Hourly and seasonable variation in catch of winter moths and bruce spanworm in pheromone-baited traps

Science.gov (United States)

Joseph Elkinton; Natalie Leva; George Boettner; Roy Hunkins; Marinko. Sremac

2011-01-01

Elkinton et al. recently completed a survey of northeastern North America for the newly invasive winter moth, Operophtera brumata L. The survey used traps baited with the winter moth pheromone, which, as far as it is known, consists of a single compound that is also used by Bruce spanworm, the North American congener of winter moth, O....

Two new species of the stenopodidean shrimp genus Spongiocaris Bruce & Baba, 1973 (Crustacea: Decapoda: Spongicolidae) from the Indo-West Pacific.

Science.gov (United States)

Komai, Tomoyuki; Grave, Sammy De; Saito, Tomomi

2016-05-17

Two new species of the deep-water spongicolid genus Spongiocaris Bruce & Baba, 1973, are described and illustrated from two localities in the Indo-West Pacific. Spongiocaris panglao n. sp. is described on the basis of material from the Bohol Sea, the Philippines, at depths of 220-731 m. Spongiocaris tuerkayi n. sp. is described on the basis of material from Atlantis Bank in the southwestern Indian Ocean at depths of 743-1053 m. Among eight known congeners, both new species appear close to S. semiteres Bruce & Baba, 1973, differing in the rostral length and armature, shape of the carapace, telsonal armature, development of the grooming apparatus of the first pereopod and shape of the third pereopod chela. An identification key to the species currently assigned to Spongiocaris is presented.

Fuel string supporting shield plug (f3sp) for Ontario Hydro - Bruce NGSA

Energy Technology Data Exchange (ETDEWEB)

Henry, P T [Canadian General Electric Co. Ltd., Peterborough, ON (Canada)

1997-12-31

A reactor `power pulse` problem was identified for the Ontario Hydro Bruce generating stations. On a postulated inlet header break, the fuel strings in a large number of channels could relocate toward the upstream end, resulting in a power pulse. The solution adopted for Bruce GSA is to change the direction of fuelling, from against the flow, to fuelling with the flow. In this revised fuelling scheme, given a postulated inlet header failure, the fuel bundle with the highest burnup would relocate into the reactor core and introduce a negative reactivity during the accident. However, this fuelling configuration results in a highly irradiated fuel bundle residing in the most downstream position against the latch. The latch supports only the outer ring of elements, not the end plate. A resulting high stress on the end plate coupled with high levels of hydrogen and deuterium may result in Zr hydride assisted cracking in the end plate during hot shutdown conditions. (In fuelling against flow, this is not a problem, since the latch supported bundle is not irradiated and has only low levels of hydrogen and deuterium.) A fuel string supporting shield plug (f3sp) which supports the bundle end plate has been developed as a solution to the fuel bundle end plate cracking problem. It would replace the existing outlet shield plug in all channels. This paper will describe the f3sp design, associated fuel handling, operation and qualification for reactor use. (author). 8 figs.

Fuel string supporting shield plug (f3sp) for Ontario Hydro - Bruce NGSA

International Nuclear Information System (INIS)

Henry, P.T.

1996-01-01

A reactor 'power pulse' problem was identified for the Ontario Hydro Bruce generating stations. On a postulated inlet header break, the fuel strings in a large number of channels could relocate toward the upstream end, resulting in a power pulse. The solution adopted for Bruce GSA is to change the direction of fuelling, from against the flow, to fuelling with the flow. In this revised fuelling scheme, given a postulated inlet header failure, the fuel bundle with the highest burnup would relocate into the reactor core and introduce a negative reactivity during the accident. However, this fuelling configuration results in a highly irradiated fuel bundle residing in the most downstream position against the latch. The latch supports only the outer ring of elements, not the end plate. A resulting high stress on the end plate coupled with high levels of hydrogen and deuterium may result in Zr hydride assisted cracking in the end plate during hot shutdown conditions. (In fuelling against flow, this is not a problem, since the latch supported bundle is not irradiated and has only low levels of hydrogen and deuterium.) A fuel string supporting shield plug (f3sp) which supports the bundle end plate has been developed as a solution to the fuel bundle end plate cracking problem. It would replace the existing outlet shield plug in all channels. This paper will describe the f3sp design, associated fuel handling, operation and qualification for reactor use. (author). 8 figs

Restoration to serviceability of Bruce 'A' heat transfer equipment

International Nuclear Information System (INIS)

Gammage, D.; Machowski, C.; McGillivray, R.; Durance, D.; Kazimer, D.; Werner, K.

2009-01-01

Bruce Units 1 to 4 were shut down during the 1990s by the former Ontario Hydro, due in part to a long list of system and equipment deficiencies and concerns, including steam generator tube degradation as a consequence of the then-existing steam generator secondary side water chemistry conditions. Upon its creation in 2001, and following a program of condition assessment, Bruce Power was able to determine that Units 3 and 4 could return to service; but that Units 1 and 2 would require refurbishment. That Refurbishment Program, which is currently well advanced, included the re-assessment of the condition of equipment throughout the plant including the heat transfer equipment; and determination item-by-item as to what inspection, cleaning, repair, or even replacement would be required to put the equipment into a condition where it could be expected to operate reliably for the additional 30 years expected from the plant. Clearly the objective is to suitably restore the equipment to serviceability without doing more refurbishment work than is warranted - without replacing equipment except where absolutely necessary. The first task in such a program is determination of its scope - i.e. a listing of all heat exchangers. That list included everything from the steam generators (which required replacement, now completed), to much smaller heat exchangers in the heavy water upgrader systems (which were found to be in very good overall condition). There is also a very large number of other so-called 'balance-of-plant' heat exchangers; these include the maintenance coolers, moderator heat exchangers, shutdown coolers and a whole raft of smaller coolers - many of which are cooled directly by lake water with its potential for bio-fouling and 'BIC' (Biologically Induced Corrosion). This paper focuses primarily on the engineering assessment, inspection, repair and general refurbishment of the balance-of-plant heat exchangers. As will be discussed in the paper, the assessment of the

Spontaneous fission of 259Md

International Nuclear Information System (INIS)

Hulet, E.K.; Wild, J.F.; Lougheed, R.W.; Baisden, P.A.; Landrum, J.H.; Dougan, R.J.; Mustafa, M.; Ghiorso, A.; Nitschke, J.M.

1979-01-01

The mass and kinetic energy distributions of fission fragments from the spontaneous fission of th newly discovered nuclide 259 Md were obtained. 259 Md was identified as the E. C. daughter of 259 No, and was found to decay entirely (> 95%) by spontaneous fission with a 95-min half-life. From the kinetic energies measured for 397 pairs of coincident fragments, a mass distribution was derived that is symmetric with sigma = 13 amu. 259 Md, together with 258 Fm and 259 Fm, form a select group of three nuclides whose mass division in spontaneous fission is highly symmetric. Unlike the total-kinetic-energy (TKE) distributions of 258 Fm and 259 Fm, which peak at approx. = to 240 MeV, this distribution for 259 Md is broad and is 50 MeV lower in energy. Analysis of the mass and energy distributions shows that events near mass symmetry also exhibit a broad TKE distribution, with one-third of the symmetric events having TKEs less than 200 MeV. The associated of low TKEs with symmetric mass division in the fission of very heavy actinides is anomalous and inconsistent with theories based upon the emergence of fragment shells near the scission point. Either three-body fragmentation or peculiar fragment shapes are assumed as the cause for the large consumption of Coulomb energy observed for a significant fraction of symmetric fissions in 259 Md. 6 figures

Evaluation of a pilot fish handling system at Bruce NGS 'A'

International Nuclear Information System (INIS)

Griffiths, J.S.

1985-10-01

A pilot fish recovery system using a Hidrostal fish pump was tested in the Bruce NGS 'A' forebay during June, 1984. Despite low forebay fish concentrations, the system was capable of capturing 97,000 alewife/day (3900 kg) if operated continuously. Post-pumping survival averaged 97%. It is estimated that a single pump could handle alewife runs in the 40,000 to 70,000 kg range, but multiple pumps or a single larger pump would be required to assure station protection from the largest runs (>100,000 kg). Results indicate that tank/trailer return of pumped fish is feasible, but other alternatives for returning fish to Lake Huron are also being considered

Prehospital Use of Plasma for Traumatic Hemorrhage - PUPTH-IIA

Science.gov (United States)

2016-08-01

Distribution Unlimited 1 Jun 2012 - 31 May 2016 W81XWH-12-2-0022 13. SUPPLEMENTARY NOTES Dr. Bruce Spiess , MD, Penny S. Reynolds, PhD, (Study PIs) and...decision for termination of the PUPTH trial before the end of the award period was made by Dr. Bruce Spiess (Principal Investigator) and the PUPTH...results and recommendations for future trial management have been submitted for publication in Trials and are currently under review.  Dr Spiess and

MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

Science.gov (United States)

An, Xiu-Hong; Tian, Yi; Chen, Ke-Qin; Liu, Xiao-Juan; Liu, Dan-Dan; Xie, Xing-Bin; Cheng, Cun-Gang; Cong, Pei-Hua; Hao, Yu-Jin

2015-04-01

Anthocyanin and proanthocyanidin (PA) are important secondary metabolites and beneficial to human health. Their biosynthesis is induced by jasmonate (JA) treatment and regulated by MYB transcription factors (TFs). However, which and how MYB TFs regulate this process is largely unknown in apple. In this study, MdMYB9 and MdMYB11 which were induced by methyl jasmonate (MeJA) were functionally characterized. Overexpression of MdMYB9 or MdMYB11 promoted not only anthocyanin but also PA accumulation in apple calluses, and the accumulation was further enhanced by MeJA. Subsequently, yeast two-hybrid, pull-down and bimolecular fluorescence complementation assays showed that both MYB proteins interact with MdbHLH3. Moreover, Jasmonate ZIM-domain (MdJAZ) proteins interact with MdbHLH3. Furthermore, chromatin immunoprecipitation-quantitative PCR and yeast one-hybrid assays demonstrated that both MdMYB9 and MdMYB11 bind to the promoters of ANS, ANR and LAR, whereas MdbHLH3 is recruited to the promoters of MdMYB9 and MdMYB11 and regulates their transcription. In addition, transient expression assays indicated that overexpression of MdJAZ2 inhibits the recruitment of MdbHLH3 to the promoters of MdMYB9 and MdMYB11. Our findings provide new insight into the mechanism of how MeJA regulates anthocyanin and PA accumulation in apple. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Mitigation of organically bound sulphate from water treatment plants at Bruce NGS and impact on steam generator secondary side chemistry control

Energy Technology Data Exchange (ETDEWEB)

Nashiem, R.; Davloor, R.; Harper, B.; Smith, K. [Bruce Power, Tiverton, Ontario (Canada); Gauthier, C. [CTGIX Services Inc., Burlington, Ontario (Canada); Schexnailder, S. [GE Water and Process Technologies, Dallas, Texas (United States)

2010-07-01

Bruce Power is the source of more than 20 per cent of Ontario's electricity and currently operates six reactor units at the Bruce Nuclear Generating Station A (two units) and B (four units) stations located on Lake Huron. This paper discusses the challenges faced and operating experience (OPEX) gained in meeting WANO 1.0 chemistry performance objectives for steam generator secondary side chemistry control, particularly with control of steam generator sulphates. A detailed sampling and analysis program conducted as part of this study concluded that a major contributor to steam generator (SG) elevated sulphates is Organically Bound Sulphate (OBS) in Water Treatment Plants (WTP) effluent. The Bruce A and B WTPs consist of clarification with downstream sand and carbon filtration for Lake Water pre-treatment, which are followed by conventional Ion Exchange (IX) demineralization. Samples taken from various locations in the process stream were analyzed for a variety of parameters including both organic bound and inorganic forms of sulphate. The results are inconclusive with respect to finding the definitive source of OBS. This is primarily due to the condition that the OBS in the samples, which are in relatively low levels, are masked during chemical analysis by the considerably higher inorganic sulphate background. Additionally, it was also determined that on-line Total Organic Carbon (TOC) levels at different WTP locations did not always correlate well with OBS levels in the effluent, such that TOC could not be effectively used as a control parameter to improve OBS performance of the WTP operation. Improvement efforts at both plants focused on a number of areas including optimization of clarifier operation, replacement of IX resins, addition of downstream mobile polishing trailers, testing of new resins and adsorbents, pilot-scale testing with a Reverse Osmosis (RO) rig, review of resin regeneration and backwashing practices, and operating procedure improvements

Mitigation of organically bound sulphate from water treatment plants at Bruce NGS and impact on steam generator secondary side chemistry control

International Nuclear Information System (INIS)

Nashiem, R.; Davloor, R.; Harper, B.; Smith, K.; Gauthier, C.; Schexnailder, S.

2010-01-01

Bruce Power is the source of more than 20 per cent of Ontario's electricity and currently operates six reactor units at the Bruce Nuclear Generating Station A (two units) and B (four units) stations located on Lake Huron. This paper discusses the challenges faced and operating experience (OPEX) gained in meeting WANO 1.0 chemistry performance objectives for steam generator secondary side chemistry control, particularly with control of steam generator sulphates. A detailed sampling and analysis program conducted as part of this study concluded that a major contributor to steam generator (SG) elevated sulphates is Organically Bound Sulphate (OBS) in Water Treatment Plants (WTP) effluent. The Bruce A and B WTPs consist of clarification with downstream sand and carbon filtration for Lake Water pre-treatment, which are followed by conventional Ion Exchange (IX) demineralization. Samples taken from various locations in the process stream were analyzed for a variety of parameters including both organic bound and inorganic forms of sulphate. The results are inconclusive with respect to finding the definitive source of OBS. This is primarily due to the condition that the OBS in the samples, which are in relatively low levels, are masked during chemical analysis by the considerably higher inorganic sulphate background. Additionally, it was also determined that on-line Total Organic Carbon (TOC) levels at different WTP locations did not always correlate well with OBS levels in the effluent, such that TOC could not be effectively used as a control parameter to improve OBS performance of the WTP operation. Improvement efforts at both plants focused on a number of areas including optimization of clarifier operation, replacement of IX resins, addition of downstream mobile polishing trailers, testing of new resins and adsorbents, pilot-scale testing with a Reverse Osmosis (RO) rig, review of resin regeneration and backwashing practices, and operating procedure improvements

Muscular Dystrophy (MD)

Science.gov (United States)

... patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. View Full Treatment Information Definition The muscular dystrophies (MD) are a group of more than 30 ...

ProtoMD: A prototyping toolkit for multiscale molecular dynamics

Science.gov (United States)

Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

2016-05-01

ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

AECB staff annual assessment of the Bruce Heavy Water Plant for the year 1994

International Nuclear Information System (INIS)

1995-06-01

This report is the Atomic Energy Control Board staff assessment of the operation of Bruce Heavy Water Plant (BHWP) during 1994. BHWP operation was acceptably safe in 1994. At BHWP, Ontario Hydro did not breach any of the regulations issued under the authority of the Atomic Energy Control Act. There were four minor violations of the BHWP Operating Licence. In all cases, Ontario Hydro exceeded Ontario Hydro government limits for releases to the environment. None of the events threatened public health or the environment. 2 figs

Responses of platinum, vanadium and cobalt self-powered flux detectors near simulated booster rods in a ZED-2 mockup of a Bruce reactor core

International Nuclear Information System (INIS)

French, P.M.; Shields, R.B.; Kroon, J.C.

1978-02-01

The static responses of Pt, V and Co self-powered detectors have been compared with copper-foil neutron activation profiles in reference and perturbed Bruce reactor core mockups assembled in the ZED-2 test reactor at Chalk River Nuclear Laboratories. The results indicate that the normalized response of each self-powered detector is an accurate measure of the thermal-neutron flux at locations greater than one lattice pitch from either a booster rod or the core boundary. They indicate that, in the Bruce booster/detector configuration, the normalized static Pt response overestimates the neutron flux by less than 3.5% upon full booster-rod insertion. (author)

Control maintenance training program for special safety systems at Bruce B

International Nuclear Information System (INIS)

Reinwald, G.

1997-01-01

It was recognized from the early days of commissioning of Bruce B that Control Maintenance staff would require a level of expertise to be able to maintain Special Safety Systems in proper running order. In the early 80's this was achieved through hands on experience during the original commissioning, troubleshooting and placing of the various systems in service. Control maintenance procedures were developed and implemented as the new systems came available for commissioning, as were operating manuals,training manuals etc. Under the development of the Maintenance Manager, a Conduct of Maintenance section was organized. One of the responsibilities of this section was to develop a series of Maintenance Administrative Procedures (MAPs) that set the standards for maintenance activities including training

Harvesting graphics power for MD simulations

NARCIS (Netherlands)

van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

2008-01-01

We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

Harvesting graphics power for MD simulations

NARCIS (Netherlands)

Meel, J.A. van; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

Science.gov (United States)

Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

2018-07-01

Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

AECB staff annual assessment of the Bruce Heavy Water Plant for the year 1995

International Nuclear Information System (INIS)

1996-06-01

The Atomic Energy Control Board's staff annual assessment of the operation of Bruce Heavy Water Plant (BHWP) during 1995. BHWP operation was acceptably safe in 1995. At BHWP, Ontario Hydro complied with the regulations issued under the authority of the Atomic Energy Control Act. AECB is satisfied that BHWP did not pose any undue risk to public health or safety or to the environment. Ontario Hydro met all safety system and safety related system availability targets at BHWP in 1995. The emergency response capability is satisfactory. 2 figs

MD2190: Q" Stabilization during injection

CERN Document Server

Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2018-01-01

This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

Fuel handling solutions to power pulse at Bruce NGS A

International Nuclear Information System (INIS)

Day, R.C.

1996-01-01

In response to the discovery of the power pulse problem in March of 1993, Bruce A has installed flow straightening shield plugs in the inner zone channels of all units to partially reduce the gap and gain an increase in reactor power to 75%. After review and evaluation of solutions to manage the gap, including creep compensators and long fuel bundles, efforts have focused on a different solution involving reordering the fuel bundles to reverse the burnup profile. This configuration is maintained by fuelling with the flow and providing better support to the highly irradiated downstream fuel bundles by changing the design of the outlet shield plug. Engineering changes to the fuel handling control system and outlet shield plug are planned to be implemented starting in June 1996, thereby eliminating the power pulse problem and restrictions on reactor operating power. (author). 2 refs., 1 tab., 2 figs

Fuel handling solutions to power pulse at Bruce NGS A

Energy Technology Data Exchange (ETDEWEB)

Day, R C [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1997-12-31

In response to the discovery of the power pulse problem in March of 1993, Bruce A has installed flow straightening shield plugs in the inner zone channels of all units to partially reduce the gap and gain an increase in reactor power to 75%. After review and evaluation of solutions to manage the gap, including creep compensators and long fuel bundles, efforts have focused on a different solution involving reordering the fuel bundles to reverse the burnup profile. This configuration is maintained by fuelling with the flow and providing better support to the highly irradiated downstream fuel bundles by changing the design of the outlet shield plug. Engineering changes to the fuel handling control system and outlet shield plug are planned to be implemented starting in June 1996, thereby eliminating the power pulse problem and restrictions on reactor operating power. (author). 2 refs., 1 tab., 2 figs.

Distributed and collaborative: Experiences of local leadership of a first-year experience program

Directory of Open Access Journals (Sweden)

Jo McKenzie

2017-07-01

Full Text Available Local level leadership of the first year experience (FYE is critical for engaging academic and professional staff in working collaboratively on a whole of institution focus on student transition and success. This paper describes ways in which local informal leadership is experienced at faculty level in an institutional FYE program, based on interviews with faculty coordinators and small grant recipients. Initial analysis using the distributed leadership tenets described by Jones, Hadgraft, Harvey, Lefoe, and Ryland (2014 revealed features that enabled success, such as collaborative communities, as well as faculty differences influenced by the strength of the external mandate for change in the FYE. More fine-grained analysis indicated further themes in engaging others, enabling and enacting the FYE program that fostered internal mandates for change: gaining buy-in; being opportunistic; making use of evidence of success and recognition; along with the need for collegial support for coordinators and self-perceptions of leadership being about making connections, collaboration, trust and expertise.

Studies of the Effects of Perfluorocarbon Emulsions on Platelet Number and Function in Models of Critical Battlefield Injury

Science.gov (United States)

2016-09-01

notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it...Jiepei Zhu, MD PhD, Bruce D. Spiess, MD. Evaluation of Noninvasive Cardiac Output Monitoring in Sheep with Hemodynamic Instability 2. 2016,Aug, Military...Zhu, J., Holloway, K.L., Parsons, J.T. Intracerebral hematoma incidence in a coagulopathic sheep model of deep brain stimulation (DBS) surgery

The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple.

Science.gov (United States)

Zhou, Li-Jie; Li, Yuan-Yuan; Zhang, Rui-Fen; Zhang, Chun-Ling; Xie, Xing-Bin; Zhao, Cheng; Hao, Yu-Jin

2017-10-01

MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its post-translational regulation. Here, a small ubiquitin-like modifier E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability. Moreover, the transcription level of MdSIZ1 gene was remarkably induced by low temperature and phosphorus deficiency, and MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions. Our findings reveal an important role for a small ubiquitin-like modifier modification of MYB transcription factors in regulation of anthocyanin biosynthesis in plants. © 2017 John Wiley & Sons Ltd.

SORO post-simulations of Bruce A Unit 4 in-core flux detector verification tests

Energy Technology Data Exchange (ETDEWEB)

Braverman, E.; Nainer, O. [Bruce Power, Nuclear Safety Analysis and Support Dept., Toronto, Ontario (Canada)]. E-mail: Evgeny.Braverman@brucepower.com; Ovidiu.Nainer@brucepower.com

2004-07-01

During the plant equipment assessment prior to requesting approval for restart of Bruce A Units 3 and 4 it was determined that all in-core flux detectors needed to be replaced. Flux detector verification tests were performed to confirm that the newly installed detectors had been positioned according to design specifications and that their response closely follows the calculated flux shape changes caused by selected reactivity mechanism movements. By comparing the measured and post-simulated RRS and NOP detector responses to various perturbations, it was confirmed that the new detectors are wired and positioned correctly. (author)

MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

Science.gov (United States)

Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

2012-01-01

MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

Freshmen Marketing: A First-Year Experience with Experiential Learning

Science.gov (United States)

Greene, Henry

2011-01-01

This paper describes an experiential learning activity designed for a New England university freshmen course, BUS101-Marketing First-Year Experience (FYE). The purpose of the activity is to teach basic principles of marketing, develop a general perspective of business, and provide FYE activities that facilitate the college transition. The specific…

Analogue to digital upgrade project-boiler feedwater control system for Bruce Power nuclear units 1 & 2

International Nuclear Information System (INIS)

Long, R.

2012-01-01

Bruce Power Nuclear Generating Station A, “Bruce A” is in the final stages of its Restart Project. This capital project will see a large scale rehabilitation of Units 1 and 2 resulting in addition of 1500MW of safe, reliable, clean electricity to the Ontario grid. Restart Project Scope 375, Boiler Feedwater Controls Upgrade was sanctioned to replace obsolete analog devices with a modern digital control system. This project replaced the existing Foxboro H Line analog controls which comprised of 81 individual control modules and support instrumentation. The replacement system was a Triconex Triple Modular Redundant PLC which interfaces with two redundant touch screen monitors. The upgraded digital system incorporates the following controls: 1. Boiler Level Control Loops 2. Dearator Level Control Loops 3. Dearator Pressure Control Loops 4. Boiler Feedwater Recirculation Flow Control Loops A number of technical challenges were addressed when installing a new digital system within the existing plant configuration. Interfaces to new, old and refurbished field devices must be understood as well as implications of connecting to the plant’s Digital Control Computers (DCC’s) and newly installed Steam Generators. The overall project involved many stakeholders to address various requirements from conceptual / design stage through procurement, construction, commissioning and return to service. In addition, the project highlighted the unique requirements found in Nuclear Industry with respect to Human Factors and Software Quality Assurance. (author)

Bruce NGS a loss of flow analysis for effectiveness of level 2 defence-in-depth provisions

International Nuclear Information System (INIS)

Won, W.; Jiang, Y.; Kwee, M.; Xue, J.

2014-01-01

The concept of defence-in-depth is applied to CANDU (CANada Deuterium Uranium) reactor designs and operations to provide series of levels of defence to prevent accidents progressing and to provide protection for reactor and public safety. The level 2 defence-in-depth provisions are designed to detect and intercept deviation from normal operation in order to prevent anticipated operating occurrences (AOOs) from escalating to accident conditions, and to return the plant to a state of normal operations, according to the Canada Nuclear Safety Commission (CNSC) regulatory document RD-337. Historically, safety analysis has focused on the effectiveness of level 3 defence-in-depth provisions in accident conditions, and the effectiveness of level 2 defence-in-depth has not been assessed. In this study, the effectiveness of Level 2 defence-in-depth is assessed for loss of flow (LOF) events for Bruce Nuclear Generating Station (NGS) A reactors. The level 2 defence-in-depth in Bruce NGS A design is identified to be the stepback function of reactor regulating system (RRS). The behavior of RRS stepback following the initiation of loss of flow event is simulated using RFSP/TUF/RRS - em coupled code. The behavior of full system and single channel is simulated and assessed against the acceptance criteria - fitness for service of systems, structures and components (SSCs). (author)

Bruce NGS a loss of flow analysis for effectiveness of level 2 defence-in-depth provisions

Energy Technology Data Exchange (ETDEWEB)

Won, W. [AMEC NSS, Toronto, ON (Canada); Jiang, Y.; Kwee, M.; Xue, J. [Bruce Power, Toronto, ON (Canada)

2014-07-01

The concept of defence-in-depth is applied to CANDU (CANada Deuterium Uranium) reactor designs and operations to provide series of levels of defence to prevent accidents progressing and to provide protection for reactor and public safety. The level 2 defence-in-depth provisions are designed to detect and intercept deviation from normal operation in order to prevent anticipated operating occurrences (AOOs) from escalating to accident conditions, and to return the plant to a state of normal operations, according to the Canada Nuclear Safety Commission (CNSC) regulatory document RD-337. Historically, safety analysis has focused on the effectiveness of level 3 defence-in-depth provisions in accident conditions, and the effectiveness of level 2 defence-in-depth has not been assessed. In this study, the effectiveness of Level 2 defence-in-depth is assessed for loss of flow (LOF) events for Bruce Nuclear Generating Station (NGS) A reactors. The level 2 defence-in-depth in Bruce NGS A design is identified to be the stepback function of reactor regulating system (RRS). The behavior of RRS stepback following the initiation of loss of flow event is simulated using RFSP/TUF/RRS{sub -}em coupled code. The behavior of full system and single channel is simulated and assessed against the acceptance criteria - fitness for service of systems, structures and components (SSCs). (author)

Bruce's Magnificent Quartet: Inquiry, Community, Technology and Literacy--Implications for Renewing Qualitative Research in the Twenty-First Century

Science.gov (United States)

Davidson, Judith

2014-01-01

Bruce and Bishop's community informatics work brings forward four critical concepts: inquiry, community, technology, and literacy. These four terms serve as the basis for a discussion of qualitative research in the twenty-first century--what is lacking and what is needed. The author suggests that to resolve the tensions or challenges…

Enhancing Learning Power through First-Year Experiences for Students Majoring in STEM Disciplines

Science.gov (United States)

Koch, Robert; Kucsera, John; Angus, Kathryn Bartle; Norman, Kimberly; Bowers, Erica; Nair, Pradeep; Moon, Hye Sun; Karimi, Afshin; Barua, Susamma

2018-01-01

Academic programs targeted for first-time students can help their persistence in STEM majors. Our project, ASCEND STEM, included three first-year experiences (FYEs) designed to offer students the skills that would help them successfully traverse potential barriers to academic success. In the FYEs, we sought to strengthen the learning power,…

Corrosion-product inventory: the Bruce-B secondary system

International Nuclear Information System (INIS)

Sawicki, J.A.; Price, J.; Brett, M.E.

1995-01-01

Corrosion inspection and corrosion-product characterization in water and steam systems are important for component and systems maintenance in nuclear power stations. Corrosion products are produced, released and redeposited at various sites in the secondary system. Depending on the alloys used in the condenser and feedwater heaters, particulate iron oxides and hydroxides can account for about 95-99% of the total corrosion-product transport. Where brass or cupro-nickel alloys are present, copper and zinc contribute significantly to the total transport and deposition. Particulates are transported by the feedwater to the steam generators, where they accumulate and can cause a variety of problems, such as loss of heat transfer capability through deposition on boiler tubes, blockage of flow through boiler-tube support plates and accelerated corrosion in crevices, either in deep sludge piles or at blocked tube supports. The influx of oxidized corrosion products may have a particularly adverse effect on the redox environment of steam generator tubing, thereby increasing the probability of localized corrosion and other degradation mechanisms. In this paper, there is a description of a survey of general corrosion deposits in Bruce-B, Units 5-8, which helps to identify the origin, evolution and inventory of corrosion products along the secondary system of Candu reactors

Chemical cleaning of the Bruce A steam generators

International Nuclear Information System (INIS)

Le Surf, J.E.; Mason, J.B.; Symmons, W.R.; Yee, F.

1992-01-01

Deposits consisting mostly of oxides and salts and copper metal in the secondary side of the steam generators at the Bruce A Nuclear Generating Station have caused instability in the steam flow and loss of heat capacity, resulting in derating of the units and reduction in power production. Attempts to remove the deposits by pressure pulsing were unsuccessful. Water lancing succeeded in restoring stability, but restrictions on access prevented complete lancing of the tube support plate holes. Chemical cleaning using a modified EPRI-SGOG process has been selected as the best method of removing the deposits. A complete chemical cleaning system has been designed and fabricated for Ontario Hydro by Pacific Nuclear, with support from AECL CANDU and their suppliers. The system consists of self contained modules which are easily interconnected on site. The whole process is controlled from the Control Module, where all parameters are monitored on a computer video screen. The operator can control motorized valves, pumps and heaters from the computer key board. This system incorporates all the advanced technologies and design features that have been developed by Pacific Nuclear in the design, fabrication and operation of many systems for chemical decontamination and cleaning of nuclear systems. 2 figs

75 FR 3217 - J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License...

Science.gov (United States)

2010-01-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11392-009] J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License and Soliciting Comments and Motions To Intervene January 12, 2010. On October 30, 2009, J&T Hydro Company (transferor) and...

The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

Science.gov (United States)

Dash, Madhumita; Malladi, Anish

2012-06-25

Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

AECB staff annual report of Bruce B NGS for the year 1991

International Nuclear Information System (INIS)

1992-11-01

In this account of Bruce NGS B station operation during the year 1991 AECB staff have pointed out non-compliances with the operating licence, which have been few in number and minor in degree of seriousness. There were no exposures of workers to radiation in excess of regulatory limits, but there were contraventions of the ALARA principle. Releases of radioactive material to the environment have been well below the target levels. The performance of the four special safety systems has been good, except for the containment system. A review of the significant event reports and the causes of the events has revealed a lack of a system by which operations and maintenance work could be verified to have been carried out as intended. In operations and maintenance the backlog of work to be done to regularize temporary changes to equipment (removal of jumpers), to carry out preventive maintenance (call-ups), and to make repairs (deficiency reports) has increased from that of the previous year. On the other hand, the station has reduced the number of temporary operating instructions (operating memos) to half of what it was last year. The fretting of steam generator tubes reported last year has not become worse. Nevertheless, inspections continue and modifications to the tube supports are underway. Overall plant chemistry has been acceptable. An Ontario Hydro assessment of the station found the station management's expectations for maintaining the margin of safety in the plant had not been properly communicated to all levels of station staff. The station is now attempting to correct this. Infractions of work protection procedures, which were the subject of many significant events, have led to changes in the procedures and resulted in a major training effort. AECB staff believe that Ontario Hydro has continued to operate Bruce NGS B in a safe manner, but have pointed out areas where improvement is required. (Author)

Machine Intelligence, a Foreword: The Brain as Electronic Circuitry; Electronic Circuitry as a Brain

Science.gov (United States)

1992-06-01

Precribed byv ANSi Sto Z39-!8 296-.102 TABLE OF CONTENTS THE BOTTO M LINE ............................................................. I BACKG RO UN D...DIRECTOR US ARMY BALLISTIC RESEARCH LABORATORY ATTN: SLCBR-IB-M (DR. BRUCE BURNS ) 1 ABERDEEN PROVING GROUND, MD 21005-5066 NOTE: PLEASE NOTIFY COMMANDER

Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

Science.gov (United States)

Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

2015-10-01

Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Mediador cultural ou antropólogo do mal: Bruce Albert e o caso de “A queda do céu”

Directory of Open Access Journals (Sweden)

Karla Alessandra Alves de Souza Ferreira

2017-07-01

Full Text Available Este estudo desenvolve uma análise crítica sobre o fragmento “Postscriptum, quando eu é um outro (e vice-versa”, apresentado na obra A Queda do céu: palavras de um xamã yanomami. O livro foi pensado por um xamã yanomami; Davi Kopenawa, e produzido por um etnólogo francês Bruce Albert. Problematizo o processo de produção do livro onde dois universos culturais se encontram, uma produção literária indígena do povo Yanomami que apresenta uma coautoria. Essa análise busca investigar a postura epistêmica de Bruce Albert como mediador cultural ou “antropólogo do mal” no processo de elaboração do livro, a fim de levantar questionamentos sobre o ato tradutório e suas implicações, destacando os desa os e contribuições apresentadas nesse processo. Nesta direção, esse artigo se fundamenta nos pensamentos da história cultural.

Primary Water Chemistry Control during a Planned Outage at Bruce Power

International Nuclear Information System (INIS)

Ma, Guoping; Nashiem, Rod; Matheson, Shane; Yabar, Berman; Harper, Bill; Roberts, John G.

2012-09-01

Bruce Power has developed a comprehensive outage water chemistry program, which includes both primary and secondary chemistry requirements during planned outages. The purpose of the program is to emphasize the chemistry requirements during outages and subsequent start-ups in order to maintain the integrity of the systems, minimise activity transport and radiation fields, reduce the Carbon-14 release, and to ensure that the requirements are integrated with the outage management program. Prior to a planned outage, Station Chemical Technical Sections identify outage chemistry requirements to Operations and Outage Planning and ensure that work necessary to correct system chemistry issues is within outage work scope. The outage water chemistry program provides direction for establishing alternative sampling locations as demanded by the system configuration during the outage and identifies outage prerequisites for nuclear system purification capabilities. These requirements are contained in an outage checklist. The paper mainly highlights the primary water chemistry issues and chemistry control strategies during planned outages and discusses challenges and successes. (authors)

Water lancing of Bruce-A Unit 3 and 4 steam generators

International Nuclear Information System (INIS)

Puzzuoli, F.V.; Murchie, B.; Allen, S.

1995-01-01

During the Bruce-A 1993 Unit 4 and 1994 Unit 3 outages, three water lancing operations were carried out along with chemical cleaning as part of the station boiler refurbishment program. The water lancing activities focused on three boiler areas.. 1) support plates to clean partially or completely blocked broach holes and prevent boiler water level oscillations, 2) hot leg U-bend supports (HLUBS) to remove deposits contributing to boiler tube stress corrosion cracking (SCC) and 3) tube sheets to dislodge sludge piles that potentially threaten boiler tube integrity and to flush out post chemical cleaning insoluble residues. The combination of water lancing and chemical cleaning effectively reduced broach hole blockage from up to 100% to 0-10% or less. As a result, boilers in Units 3 and 4 will operate for some time to come without concerns over water level oscillations. However, deposits remained in most tube support plate land areas. (author)

MD290: Q4 IP6 Quench Level

CERN Document Server

Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

2016-01-01

The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

Chosen-Prefix Collisions for MD5 and Applications

NARCIS (Netherlands)

M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

2012-01-01

textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

Science.gov (United States)

Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

2016-01-01

Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

Feasibility analysis of the utilization of moderator heat for agricultural and aquacultural purposes, Bruce nuclear power development

International Nuclear Information System (INIS)

1977-12-01

A study is presented of the feasibility of using moderator reject heat from the Bruce nuclear power development either to heat greenhouses or to aid in a warm water hatchery or aquaculture operation. The study examines heat extraction and delivery plans, reliability of supply, pricing schedules, the Ontario greenhouse industry, site selection criteria, water transmission and distribution, costs, approvals required, and a construction timetable. Total system analysis shows that a greenhouse facility would be viable but the aquaculture/hatchery scheme is more cost-effective. (E.C.B.)

Swiss national MD-PhD-program: an outcome analysis.

Science.gov (United States)

Kuehnle, Katrin; Winkler, David T; Meier-Abt, Peter J

2009-09-19

This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years. One hundred and twenty six former and current students in the Swiss national MD-PhD program were surveyed via a Web-based questionnaire in September 2007. Twenty-four questions assessed information regarding participant demographics, information on the PhD thesis and publication activity, current positions and research activity, as well as participant's opinions, attitudes and career goals. Eighty questionnaires were received from 126 MD-PhD students and graduates (63.5% response rate). The responders consisted of present students (36%), former graduates (56%), and dropouts (8%). The percentage of women in the program was 23%, and the average duration of the program was 4.2 +/- 1.4 years. Research interests were predominantly in the fields of neuroscience, immunology, molecular biology and cancer research. A considerable portion of the MD-PhD graduates had an excellent publication record stemming from their PhD research work, and 89% were planning to continue a research-orientated career. Over 50% of those MD-PhD graduates completing their thesis before 2002 had already reached an assistant or full professor position at the time of the survey. Nearly all participants considered the MD-PhD training helpful to their career and high quality standards were assigned to the acquired practical and intellectual skills. However, criticism was expressed concerning the general mentoring and the career related mentoring. Moreover, general mentoring and career related mentoring were significantly less well perceived in research groups employing more than seven PhD students at the same time. The MD-PhD students and graduates surveyed were satisfied with their education and most of them continued a research-orientated career. Regarding the overall positive evaluation, this study supports the view that MD-PhD graduates are well qualified for a successful career in

MD-11 PCA - Research flight team photo

Science.gov (United States)

1995-01-01

On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.

Hydraulic Testing of Silurian and Ordovician Strata at the Bruce Site

Science.gov (United States)

Beauheim, R. L.; Avis, J. D.; Chace, D. A.; Roberts, R. M.; Toll, N. J.

2009-05-01

Ontario Power Generation is proposing a Deep Geologic Repository (DGR) for the long-term management of its Low and Intermediate Level Radioactive Waste (L&ILW) within a Paleozoic-age sedimentary sequence beneath the Bruce Site near Tiverton, Ontario, Canada. The concept envisions that the DGR would be excavated at a depth of approximately 680 m within the Ordovician Cobourg Formation, a massive, dense, argillaceous limestone. A key attribute of the Bruce site is the extremely low permeabilities associated with the thick Ordovician carbonate and argillaceous bedrock formations that will host and enclose the DGR. Such rock mass permeabilities are thought sufficiently low to contribute toward or govern a diffusion-dominated transport regime. To support this concept, hydraulic testing was performed in 2008 and 2009 in two deep boreholes at the proposed repository site, DGR-3 and DGR-4. The hydraulic testing was performed using a straddle-packer tool with a 30.74-m test interval. Sequential tests were performed over the entire open lengths of the boreholes from the F Unit of the Silurian Salina Formation into the Ordovician Gull River Formation, a distance of approximately 635 m. The tests consisted primarily of pressure-pulse tests, with a few slug tests performed in several of the higher permeability Silurian units. The tests are analyzed using the nSIGHTS code, which allows the entire pressure history a test interval has experienced since it was penetrated by the drill bit to be included in the test simulation. nSIGHTS also allows the model fit to the test data to be optimized over an n-dimensional parameter space to ensure that the final solution represents a true global minimum rather than simply a local minimum. The test results show that the Ordovician-age strata above the Coboconk Formation (70+ m below the Cobourg) have average horizontal hydraulic conductivities of 1E-13 m/s or less. Coboconk and Gull River hydraulic conductivities are as high as 1E-11 m

Bruce NGS B risk assessment (BBRA) peer review process

International Nuclear Information System (INIS)

Kaasalainen, S.; Crocker, W.P.; Webb, W.A.

2001-01-01

Risk-informed decision making is considered an effective approach to managing the risk of nuclear power plant operation in a competitive market. Hence, increased reliance on the station probabilistic risk assessments (PRAs) to provide risk perspective inputs is inevitable. With increased reliance on the PRAs it is imperative that PRAs have the characteristics necessary to provide the required information. Recognizing the increased requirements on nuclear power plant PRAs the nuclear industry in the United States has expended significant effort over the past few years defining the required characteristics of a PRA for various applications. More recently several owners groups have drafted guidelines for PRA certification and several U.S. utilities have had their PRAs certified. During the year 2000 Ontario Power Generation, Nuclear (OPG,N) subjected the PRA of one of its stations to the U.S. style certification process. The PRA selected for this process was the Bruce B Risk Assessment (BBRA). BBRA was chosen for this process since it is the first OPG, N PRA to be used for risk-informed applications. However, the strengths of the BBRA identified from the certification process and the lessons learned are also largely applicable to the other OPG, N plant PRAs due to the use of similar methods and tools

Design and verification of computer-based reactor control system modification at Bruce-A candu nuclear generating station

International Nuclear Information System (INIS)

Basu, S.; Webb, N.

1995-01-01

The Reactor Control System at Bruce-A Nuclear Generating Station is going through some design modifications, which involve a rigorous design process including independent verification and validation. The design modification includes changes to the control logic, alarms and annunciation, hardware and software. The design (and verification) process includes design plan, design requirements, hardware and software specifications, hardware and software design, testing, technical review, safety evaluation, reliability analysis, failure mode and effect analysis, environmental qualification, seismic qualification, software quality assurance, system validation, documentation update, configuration management, and final acceptance. (7 figs.)

76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

Science.gov (United States)

2011-02-02

... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to.... The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke City MD, has a vertical clearance in...

76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

Science.gov (United States)

2011-08-09

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

Science.gov (United States)

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Thomas E. Mitchell, M.D....100(b) and 0.104, I hereby order that the Order to Show Cause issued to Thomas E. Mitchell, M.D., be...

77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

Science.gov (United States)

2012-02-10

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-09] Scott W. Houghton, M.D... CFR 0.100(b), I order that DEA Certificate of Registration BH8796077, issued to Scott W. Houghton, M.D., be, and it hereby is, revoked. I further order that any pending application of Scott W. Houghton, M.D...

AECB staff annual assessment of the Bruce A Nuclear Generating Station for the year 1994

International Nuclear Information System (INIS)

1995-06-01

AECB believe that Ontario Hydro operated Bruce A in a safe manner during 1994, and that the risk to workers and the public has been maintained at an acceptably low level. Radiation doses to workers and releases to the environment were well below regulatory limits. All special safety systems met availability targets. We noted improvements in operation and maintenance but some further improvements are still required. This is particularly true of the station's compliance with the Operating Licence. AECB believe that the station continues to be well managed, with a high priority placed on safety. However, there is a need for increased capability in the area of safety analysis and assessment. 4 tabs., 4 figs

Retrofitting alarm prioritization at Bruce A: strategy development and implementation experience

International Nuclear Information System (INIS)

Davey, E.; Hickey, D.; Babcock, B.

1997-01-01

A prioritization strategy for computer-displayed control room alarms has been developed for Bruce A to better assist operations staff in visually identifying key alarms and judging the relative importance of alarms. The strategy consists of assigning each alarm indicative of a problem to be addressed to one of five priority categories. Each alarm is assigned to an alarm category based on an off-line analysis of the consequence and response characteristics applicable to the alarm for three plant operating contexts. The colour of the alarm message is used to convey the priority category of each alarm in computer-based alarm displays. In addition, alarms indicative of non-problematic changes in the state of plant equipment and processes are given a separate colour assignment to visually differentiate them from alarms indicative of problems. This paper outlines the user-based approach employed in the prioritization strategy development, describes the key features of the prioritization strategy adopted, and discusses the initial experience in systematically determining the priority assignments for all 6000 computer-based alarms associated with each generating unit. (author)

Steam generator replacement at Bruce A: approach, results, and lessons learned

International Nuclear Information System (INIS)

Tomkiewicz, W.; Savage, B.; Smith, J.

2008-01-01

Steam Generator Replacement is now complete in Bruce A Units 1 and 2. In each reactor, eight steam generators were replaced; these were the first CANDU steam generator replacements performed anywhere in the world. The plans for replacement were developed in 2004 and 2005, and were summarized in an earlier paper for the CNS Conference held in November, 2006. The present paper briefly summarizes the methodologies and special processes used such as metrology, cutting and welding and heavy lifting. The paper provides an update since the earlier report and focuses on the project achievements to date, such as: - A combination of engineered methodology, laser metrology and precise remote machining led to accurate first time fit-ups of each new replacement steam generator and steam drums - Lessons learned in the first unit led to schedule improvements in the second unit - Dose received was lowest recorded for any steam generator replacement project. The experience gained and lessons learned from Units 1 and 2 will be valuable in planning and executing future replacement steam generator projects. A video was presented

Developing improved MD codes for understanding processive cellulases

International Nuclear Information System (INIS)

Crowley, M F; Nimlos, M R; Himmel, M E; Uberbacher, E C; Iii, C L Brooks; Walker, R C

2008-01-01

The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

Trends in MD/PhD Graduates Entering Psychiatry: Assessing the Physician-Scientist Pipeline.

Science.gov (United States)

Arbuckle, Melissa R; Luo, Sean X; Pincus, Harold Alan; Gordon, Joshua A; Chung, Joyce Y; Chavez, Mark; Oquendo, Maria A

2018-06-01

The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology). Linear regression and multiple linear regression determined whether these values increased over time and varied by sex. Over 14 years, an average of 18 MD/PhDs (range 13-29) enrolled in psychiatry each year. The number of MD/PhDs going into psychiatry significantly increased, although these gains were modest (less than one additional MD/PhD per year). The proportion of students entering psychiatry who were MD/PhDs varied between 2.9 and 5.9 per 100 residents, with no significant change over time. There was also no change in the percentage of MD/PhDs entering psychiatry from among all MD/PhD graduates. The rate of increase in the number of MD/PhDs going into psychiatry did not differ significantly from other specialties except for family medicine, which is decreasing. The rate of MD/PhDs going into psychiatry was higher for women, suggesting closure of the sex gap in 17 years. Despite the increase in the number of MD/PhDs entering psychiatry, these numbers remain low. Expanding the cohort of physician-scientists dedicated to translational research in psychiatry will require a multipronged approach.

Characterization of an Autophagy-related Gene MdATG8i from apple

Directory of Open Access Journals (Sweden)

Ping eWang

2016-05-01

Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

Floral micromorphology of the genus Ensete Bruce ex Horan. (Musaceae in Thailand

Directory of Open Access Journals (Sweden)

Wandee Inta

2015-09-01

Full Text Available To fulfil scarce and incomplete information on floral micromorphology of ensets (Ensete Bruce ex Horan. in the banana family (Musaceae, a comparative anatomical study of two species: E. glaucum (Roxb. Cheesman and E. superbum (Roxb. Cheesman, native to Thailand was conducted. It was found that, apart from five fertile stamens presented in other members of the Musaceae family, both ensets possess a short staminode. It is suggested from this investigation that six is the basic number of Ensete androecial whorl and the taxa could secure the most primitive status within the family and the Zingiberales order, of which stamen numbers are reduced. The results also indicated that the vascular bundle position in compound tepal, the vascular patterns in vascular zone of ovary and cell shapes of stigma epidermis and the ovary cortex are of systematic significance in conjunction with pollen size and exine ornamentation. These useful micromorphological characters can be further applied for identification of other Ensete species distribute elsewhere in the world.

[MD PhD programs: Providing basic science education for ophthalmologists].

Science.gov (United States)

Spaniol, K; Geerling, G

2015-06-01

Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

Case report

African Journals Online (AJOL)

ebutamanya

5 août 2015 ... reinforcement of berry aneurysms . J Neurosurg. 1990. Feb;72(2):163-70. PubMed | Google Scholar. 4. Giancarlo AV, Apostolides PI, Bruce Dean MD, Spetzler RF. Magnetic resonance image of post craniotomy retained cotton or rayon. J Neurosurg. 1998 May;88(5):928. PubMed |. Google Scholar. 5.

[Interpersonal motivation in a First Year Experience class influences freshmen's university adjustment].

Science.gov (United States)

Nakayama, Rumiko; Nakanishi, Yoshifumi; Nagahama, Fumiyo; Nakajima, Makoto

2015-06-01

The present study examined the influence of interpersonal motivation on university adjustment in freshman students enrolled in a First Year Experience (FYE) class. An interpersonal motivation scale and a university adjustment (interpersonal adjustment and academic adjustment) scale were administered twice to 116 FYE students; data from the 88 students who completed both surveys were analyzed. Results from structural equation modeling indicated a causal relationship between interpersonal, motivation and university adjustment: interpersonal adjustment served as a mediator between academic adjustment and interpersonal motivation, the latter of which was assessed using the internalized motivation subscale of the Interpersonal Motivation Scale as well as the Relative Autonomy Index, which measures the autonomy in students' interpersonal attitudes. Thus, revising the FYE class curriculum to include approaches to lowering students' feelings of obligation and/or anxiety in their interpersonal interactions might improve their adjustment to university.

Hydrogeological evidence of low rock mass permeabilities in ordovician strata: Bruce nuclear site

International Nuclear Information System (INIS)

Beauheim, R.L.; Roberts, R.M.; Avis, J.D.; Heagle, D.

2011-01-01

One of the key attributes contributing to the suitability of the Bruce nuclear site to host a Deep Geologic Repository (DGR) for Low and Intermediate Level Waste (L&ILW) is the low permeability of the Ordovician host rock and of the overlying and underlying strata. The permeability of these rocks is so low that diffusion is a much more significant transport mechanism than advection. Hydrogeological evidence for the low permeability of the Ordovician strata comes from two principal sources, direct and indirect. Direct evidence of low permeability is provided by the hydraulic testing performed in deep boreholes, DGR-2 through DGR-6. Straddle-packer hydraulic testing was performed in 57 Ordovician intervals in these five holes. The testing provided continuous coverage using ~30-m straddle intervals of the Ordovician strata exposed in boreholes DGR-2, DGR-3, DGR-4, and DGR-5, while testing was targeted on discontinuous 10.2-m intervals in DGR-6. The average horizontal hydraulic conductivities of these intervals determined from the tests ranged from 2E-16 to 2E-10 m/s. The Lower Member of the Cobourg Formation, which is the proposed host formation for the DGR, was found to have a horizontal hydraulic conductivity of 4E-15 to 3E-14 m/s. The only horizontal hydraulic conductivity values measured that were greater than 2E-12 m/s are from the Black River Group, located at the base of the Ordovician sedimentary sequence. Indirect evidence of low permeability is provided by the observed distribution of hydraulic heads through the Ordovician sequence. Hydraulic head profiles, defined by hydraulic testing and confirmed by Westbay multilevel monitoring systems, show significant underpressures relative to a density-compensated hydrostatic condition throughout most of the Ordovician strata above the Black River Group, whereas the Black River Group is overpressured. Pressure differences of 1 MPa or more are observed between adjacent intervals in the boreholes. The observed

3MdB: the Mexican Million Models database

Science.gov (United States)

Morisset, C.; Delgado-Inglada, G.

2014-10-01

The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

Directory of Open Access Journals (Sweden)

Cheolhoon Kim

2017-11-01

Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

Apple F-box Protein MdMAX2 Regulates Plant Photomorphogenesis and Stress Response

Directory of Open Access Journals (Sweden)

Jian-Ping An

2016-11-01

Full Text Available MAX2 (MORE AXILLARY GROWTH2 is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length. Further study indicated that MdMAX2 might promote plant photomorphogenesis by affecting the auxin signaling as well as other plant hormones. Transcripts of MdMAX2 were noticeably up-regulated in response to NaCl and Mannitol treatments. Moreover, compared with the wild type, the MdMAX2-overexpressing apple calli and Arabidopsis exhibited increased tolerance to salt and drought stresses. Taken together, these results suggest that MdMAX2 plays a positive regulatory role in plant photomorphogenesis and stress response.

Limiting Time Variations of Servomotor Torques Using the Modified Bang-Bang Controller

Science.gov (United States)

1992-06-01

LIMITATION OF ABSTRACT OP REPORT OF THIS PAGE OF ABSTRACT UNCl ID UNCIAM UNCLWSFIED UL ISNH 54-01-210-SS00 Standard Form 298 (Rev. 2-89) Precribed by ANSI...WASHINGTON, D.C. 20375 DIRECTOR US ARMY BALLISTIC RESEARCH LABORATORY ATTN: SLCBR-IB-M (DR. BRUCE BURNS ) 1 ABERDEEN PROVING GROUND, MD 21005-5066 NOTE

Waiting time distribution in M/D/1 queueing systems

DEFF Research Database (Denmark)

Iversen, Villy Bæk; Staalhagen, Lars

1999-01-01

The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

Stress corrosion cracking experience in steam generators at Bruce NGS

International Nuclear Information System (INIS)

King, P.J.; Gonzalez, F.; Brown, J.

1993-01-01

In late 1990 and through 1991, units 1 and 2 at the Bruce A Nuclear Generating Station (BNGS-A) experienced a number of steam generator tube leaks. Tube failures were identified by eddy current to be circumferential cracks at U-bend supports on the hot-leg side of the boilers. In late 1991, tubes were removed from these units for failure characterization. Two active failure modes were found: corrosion fatigue in both units 1 and 2 and stress corrosion cracking (SCC) in unit 2. In unit 2, lead was found in deposits, on tubes, and in cracks, and the cracking was mixed-mode: transgranular and intergranular. This convincingly indicated the involvement of lead in the stress corrosion cracking failures. A program of inspection and tube removals was carried out to investigate more fully the extent of the problem. This program found significant cracking only in lead-affected boilers in unit 2, and also revealed a limited extent of non-lead-related intergranular stress corrosion cracking in other boilers and units. Various aspects of the failures and tube examinations are presented in this paper. Included is discussion of the cracking morphology, measured crack size distributions, and chemical analysis of tube surfaces, crack faces, and deposits -- with particular emphasis on lead

Methyl iodide trapping efficiency of aged charcoal samples from Bruce-A emergency filtered air discharge systems

International Nuclear Information System (INIS)

Wren, J.C.; Moore, C.J.; Rasmussenn, M.T.; Weaver, K.R.

1999-01-01

Charcoal filters are installed in the emergency filtered air discharge system (EFADS) of multiunit stations to control the release of airborne radioiodine in the event of a reactor accident. These filters use highly activated charcoal impregnated with triethylenediamine (TEDA). The TEDA-impregnated charcoal is highly efficient in removing radioiodine from flowing airstreams. The iodine-removal efficiency of the charcoal is presumed to deteriorate slowly with age, but current knowledge of this effect is insufficient to predict with confidence the performance of aged charcoal following an accident. Experiments were performed to determine the methyl iodide removal efficiency of aged charcoal samples taken from the EFADS of Ontario Hydro's Bruce-A nuclear generating station. The charcoal had been in service for ∼4 yr. The adsorption rate constant and capacity were measured under post-loss-of-coolant accident conditions to determine the efficiency of the aged charcoal. The adsorption rate constants of the aged charcoal samples were observed to be extremely high, yielding a decontamination factor (DF) for a 20-cm-deep bed of the aged charcoal >1 X 10 15 . The results show that essentially no CH 3 I would escape from a 20-cm-deep bed of the aged charcoal and that the requirement for a DF of 1000 for organic iodides in the EFADS filters would be exceeded by a tremendous margin. With such high DFs, the release of iodine from a 20-cm-deep bed would be virtually impossible to detect. The adsorption capacities observed for the aged charcoal samples approach the theoretical chemisorption capacity of 5 wt% TEDA charcoal, indicating that aging in the EFADS for 4 yr has had a negligible impact on the adsorption capacity. The results indicate that the short- and long-term performances of the aged charcoal in the EFADS of Bruce-A following an accident would still far exceed performance requirements. (author)

75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

Science.gov (United States)

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Peter W.S. Grigg, M.D.; Revocation of... Order to Show Cause and Immediate Suspension of Registration to Peter W.S. Grigg, M.D. (Respondent), of... Registration, BG2107856, issued to Peter W.S. Grigg, M.D., be, and it hereby is, revoked. This Order is...

Experience in ultrasonic gap measurement between calandria tubes and liquid injection shutdown systems nozzles in Bruce Nuclear Generating Station

International Nuclear Information System (INIS)

Abucay, R.C.; Mahil, K.S.; Goszczynski, J.J.

1995-01-01

The gaps between calandria tubes (CT) and Liquid Injection Shutdown System (LISS) nozzles at the Bruce Nuclear Generating Station ''A'' (Bruce A) are known to decrease with time due to radiation induced creep/sag of the calandria tubes. If this gap decreases to a point where the calandria tubes come into contact with the LISS nozzle, the calandria tubes could fail as a result of fretting damage. Proximity measurements were needed to verify the analytical models and ensure that CT/LISS nozzle contact does not occur earlier than predicted. The technique used was originally developed at Ontario Hydro Technologies (formerly Ontario Hydro Research Division) in the late seventies and put into practical use by Research and Productivity Council (RPC) of New Brunswick, who carried out similar measurements at Point Lepreau NGS in 1989 and 1991. The gap measurement was accomplished y inserting an inspection probe, containing four ultrasonic transducers (2 to measure gaps and 2 to check for probe tilt) and a Fredericks electrolytic potentiometer as a probe rotational sensor, inside LISS Nozzle number-sign 7. The ultrasonic measurements were fed to a system computer that was programmed to convert the readings into fully compensated gaps, taking into account moderator heavy water temperature and probe tilt. Since the measured gaps were found to be generally larger than predicted, the time to CT/LISS nozzle contact is now being re-evaluated and the planned LISS nozzle replacement will likely be deferred, resulting in considerable savings

Event review: International Knapping Workshop, with Bruce Bradley, Fazenda Monte Alto, Dourado, SP (Brazil

Directory of Open Access Journals (Sweden)

Elisa Theodora Adriana van Veldhuizen

2016-07-01

Full Text Available The event took place from 3 till 8 July 2016 at Fazenda Monte Alto, Dourado, SP, Brazil. The aim of the course was to provide intensive knapping training in order to enhance analytical methods and procedures. This training was not only for students, but also professionals who were interested in the course. The course was given by Bruce Bradley (University of Exeter, who has extensive experience with Stone Age technologies and experimental archaeology. Mercedes Okumura (PPGArq, National Museum, Federal University of Rio de Janeiro and Astolfo G. M. Araujo (Museum of Archaeology and Ethnology, University of São Paulo organized the course, which was sponsored by Fazenda Monte Alto, Café Helena, and the British Academy, Newton Mobility Grants Scheme (NG140077. The workshop had 15 participants from Brazil, Uruguay, the Netherlands and Canada.

Developing the MD Explorer

Science.gov (United States)

Howie, Philip V.

1993-04-01

The MD Explorer is an eight-seat twin-turbine engine helicopter which is being developed using integrated product definition (IPD) team methodology. New techniques include NOTAR antitorque system for directional control, a composite fuselage, an all-composite bearingless main rotor, and digital cockpit displays. Three-dimensional CAD models are the basis of the entire Explorer design. Solid models provide vendor with design clarification, removing much of the normal drawing interpretation errors.

MD Anderson's Population Health Approaches to Cancer Prevention.

Science.gov (United States)

Foxhall, Lewis; Moreno, Mark; Hawk, Ernest

2018-02-01

Texas's size and unique population demographics present challenges to addressing the state's cancer burden. The University of Texas MD Anderson Cancer Center is one of 69 National Cancer Institute-designated cancer centers across the United States. While these centers traditionally have focused on research, education and training, and providing research-driven patient care, they are in a unique position to collaboratively advance population health through cancer control. Unlike the traditional academic model of a three-legged stool representing research, education, and patient care, MD Anderson's mission includes a fourth leg that incorporates population health approaches. MD Anderson has leveraged state- and national-level data and freely available resources to develop population-health priorities and a set of evidence-based actions across policy, public and professional education, and community-based clinical service domains to address these priorities. Population health approaches complement dissemination and implementation research and treatment, and will be increasingly needed to address the growing cancer burden in Texas and the nation.

My City of Ruins: Bruce Springsteen e l’utopia fra le rovine

Directory of Open Access Journals (Sweden)

Enrico Botta

2011-09-01

Full Text Available The paper focuses on My City of Ruins, the song that Bruce Springsteen sang—ten days after the 09/11 terrorist attacks—for "America: A Tribute to Heroes" and that was released in the concept album The Rising in 2002. The essay aims to highlight how the song describes the post 09/11 New York City by opposing the themes of “ruins” and “utopia.” From a textual and musical point of view, My City of Ruins is, in fact, composed of a double structure that balances different feelings: the fear, pain, and loneliness of the victims, in the rock-blues first section; the faith, love, and hope, in the gospel second part. Furthermore, the paper tries to point out how My City of Ruins no longer describes the symbolic ruins of a foreign past—in line with the nineteenth and twentieth-century American cultural tradition of the Grand Tour—but defines the physical signs of a definitively collapsed “American dream,” which can survive only in a utopian and spiritual “Promised Land.”

The predictable nature of the Paleozoic sedimentary sequence beneath the Bruce nuclear site in Southern Ontario, Canada

International Nuclear Information System (INIS)

Parmenter, Andrew; Jensen, Mark; Crowe, Richard

2012-01-01

Document available in extended abstract form only. A key aspect of a Deep Geologic Repository (DGR) safety case is the ability to develop and communicate an understanding of the geologic stability and resilience to change at time frames relevant to demonstrating repository performance. As part of an on-going Environmental Assessment, Ontario Power Generation (OPG) recently completed site-specific investigations within an 850 m thick Paleozoic sedimentary sequence beneath the Bruce nuclear site for the proposed development of a DGR for Low and Intermediate Level Waste (L and ILW). As envisioned, the shaft-accessed DGR would be excavated at a nominal depth of 680 m within the low permeability Ordovician argillaceous limestone of the Cobourg Formation, which is overlain by more than 200 m of low permeability Ordovician shale. The geo-scientific investigations revealed a relatively undeformed and laterally continuous architecture within the sedimentary sequence at the repository scale (1.5 km 2 ) and beyond. This paper explores the predictable nature of the sedimentary sequence that has contributed to increasing confidence in an understanding of the spatial distribution of groundwater system properties, deep groundwater system evolution and natural barrier performance. Multi-disciplinary geo-scientific investigations of the Bruce nuclear site were completed in 3 phases between 2006 and 2010. The sub-surface investigations included a deep drilling, coring and in-situ testing program and, the completion of a 19.7 km (9 lines) 2-D seismic reflection survey. The drilling program involved 6 (150 mm dia.) deep boreholes (4-vertical; 2 inclined) that were extended through the sedimentary sequence from 4 drill sites, arranged around the 0.3 km 2 footprint of the proposed repository. The more than 3.8 km of rock core (77 mm dia.) retrieved have provided, in part, a strong basis to understand bedrock lithology and mineralogy, facies assemblages, structure, and oil and gas

76 FR 17673 - Bienvenido Tan, M.D.; Denial of Application

Science.gov (United States)

2011-03-30

... (alprazolam) to help him sleep. Id. at 64. R.E. opted to buy the drugs from Respondent's dispensary and... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-12] Bienvenido Tan, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Bienvenido Tan, M.D...

Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

KAUST Repository

Wang, Peng; Cui, Yue; Ge, Qingchun; Fern Tew, Tjin; Chung, Neal Tai-Shung

2015-01-01

The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

KAUST Repository

Wang, Peng

2015-11-01

The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

Science.gov (United States)

2012-02-02

...-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD AGENCY: Coast Guard, DHS. ACTION: Notice... operation of the Baltimore County highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

Analysis of MD5 authentication in various routing protocols using simulation tools

Science.gov (United States)

Dinakaran, M.; Darshan, K. N.; Patel, Harsh

2017-11-01

Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

Removal of bulk contaminants from radioactive waste water at Bruce A using a clay based flocculent system

International Nuclear Information System (INIS)

Davloor, R.; Harper, B.

2011-01-01

Bruce Power's Bruce Nuclear Generating Station 'A', located on Lake Huron, has a treatment system that processes all aqueous radioactive waste water originating from the station. This Active Liquid Waste Treatment System (ALWTS) consists of collection tanks for the collection of radioactive waste water, a Pre-Treatment System (PTS) for the removal of bulk contaminants and suspended solids, a Reverse Osmosis System (ROS) to remove dissolved solids, an Evaporation and Solidification System (ESS) to concentrate and immobilize solids contained in concentrated waste streams from the ROS, and discharge tanks for the dispersal of the treated water. The ALWTS has been in continuous service since 1999 and is used to treat approximately 100,000 litres of Active Liquid Waste (ALW) each day. With the exception of tritium, it discharges waste water containing near zero concentrations of radioactive and conventional contaminants to the lake. The original design of the Bruce A ALWTS used a Backwashable Filtration System (BFS) to provide solids free water to the ROS, as measured by the Silt Density Index (SDI). During commissioning, the BFS was not successful in backwashing the solids from the filter elements. For approximately one year, a temporary solution was implemented using a Disposable Filtration System (DFS). A cationic polymer was added upstream of the DFS to agglomerate the solids. The system proved to be highly unreliable. It was difficult to agglomerate solids in the waste stream containing high amounts of detergent. As a result, DFS consumption was high and very costly. The SDI specification for the RO membrane was not always met, resulting in a quick decline of performance of the first stage ROS membranes in the treatment process. In addition, the excess cationic polymer in the RO feed caused the membranes to become fouled. In-house station staff, together with personnel from Colloid Environmental Technologies (CETCO) Company, worked to develop and

Removal of bulk contaminants from radioactive waste water at Bruce A using a clay based flocculent system

Energy Technology Data Exchange (ETDEWEB)

Davloor, R.; Harper, B. [Bruce Power, Tiverton, ON (Canada)

2011-07-01

Bruce Power's Bruce Nuclear Generating Station 'A', located on Lake Huron, has a treatment system that processes all aqueous radioactive waste water originating from the station. This Active Liquid Waste Treatment System (ALWTS) consists of collection tanks for the collection of radioactive waste water, a Pre-Treatment System (PTS) for the removal of bulk contaminants and suspended solids, a Reverse Osmosis System (ROS) to remove dissolved solids, an Evaporation and Solidification System (ESS) to concentrate and immobilize solids contained in concentrated waste streams from the ROS, and discharge tanks for the dispersal of the treated water. The ALWTS has been in continuous service since 1999 and is used to treat approximately 100,000 litres of Active Liquid Waste (ALW) each day. With the exception of tritium, it discharges waste water containing near zero concentrations of radioactive and conventional contaminants to the lake. The original design of the Bruce A ALWTS used a Backwashable Filtration System (BFS) to provide solids free water to the ROS, as measured by the Silt Density Index (SDI). During commissioning, the BFS was not successful in backwashing the solids from the filter elements. For approximately one year, a temporary solution was implemented using a Disposable Filtration System (DFS). A cationic polymer was added upstream of the DFS to agglomerate the solids. The system proved to be highly unreliable. It was difficult to agglomerate solids in the waste stream containing high amounts of detergent. As a result, DFS consumption was high and very costly. The SDI specification for the RO membrane was not always met, resulting in a quick decline of performance of the first stage ROS membranes in the treatment process. In addition, the excess cationic polymer in the RO feed caused the membranes to become fouled. In-house station staff, together with personnel from Colloid Environmental Technologies (CETCO) Company, worked to develop and

Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

KAUST Repository

Ghaffour, Noreddine

2016-09-01

An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

KAUST Repository

Ghaffour, NorEddine; Francis, Lijo; Li, Zhenyu; Valladares, Rodrigo; Alsaadi, Ahmad S.; Ghdaib, Muhannad Abu; Amy, Gary L.

2016-01-01

An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

33 CFR 110.70a - Northeast River, North East, Md.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

Directory of Open Access Journals (Sweden)

Nurvita Septya Ningrum

2016-10-01

Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

Science.gov (United States)

2012-05-18

... CFR 1316.67. Dated: May 4, 2012. Michele M. Leonhart, Administrator. Paul E. Soeffing, Esq., for the... reinstatement.'' Stuart A. Bergman, M.D., 70 Fed. Reg. 33,193 (DEA 2005); Roger A. Rodriguez, M.D., 70 Fed. Reg...

77 FR 35021 - Kwan Bo Jin, M.D.; Decision and Order

Science.gov (United States)

2012-06-12

...] DEA registration is not appropriate.'' Anibal P. Herrera, M.D., 61 FR 65,075, 65,078 (DEA 1996); see... ``there were serious questions as to the integrity of the registrant.'' Anibal P. Herrera, M.D., 61 FR 65...

Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

Directory of Open Access Journals (Sweden)

Jin Zhao

2016-03-01

Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

A pilot study of MD (psychiatry) theses-based research.

Science.gov (United States)

Srivastava, Shrikant; Agarwal, Vivek; Subramanyam, Alka; Srivastava, Mona; Sathyanarayana Rao, T S; Rao, G Prasad; Khurana, Hitesh; Singh, Archana

2018-01-01

Undertaking a research project is mandatory for MD Psychiatry trainees. The present study was undertaken to assess the type of research activity being undertaken as part of MD Psychiatry dissertation, and its contribution to national and international literature. Three medical colleges supplied the data about the topic, names of the supervisor and the candidate, collaboration, funding accrued, and publication details of MD-based research carried out between years 2000 and 2010 inclusive; 95 records were collected for the final analysis. The details of the publications provided were cross-checked on the internet, which would have taken care of missed publications as well. Most studies were single-point assessment clinical studies. Only 2 studies had been funded, 11 had collaboration with other departments within the same institute, and 5 had inter-institute collaborations. Majority of the studies were not published. Only 30 were published as full paper and 9 as abstracts. Of these 30 full publications, only 3 were published in journals having JCI impact factor values (1.4, 1.3, and 1.4, respectively). The main finding of this pilot study was that MD-based research has low contribution to the national and international literature, and those articles which are published are in low impact journals. Suggestions for modifying this state of affairs are discussed.

MD 2485: Active halo control using narrowband and colored noise excitations

CERN Document Server

Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

2018-01-01

This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

Preventive maintenance: optimization of time - based discard decisions at the bruce nuclear generating station

International Nuclear Information System (INIS)

Doyle, E.K.; Jardine, A.K.S.

2001-01-01

The use of various maintenance optimization techniques at Bruce has lead to cost effective preventive maintenance applications for complex systems. As previously reported at ICONE 6 in New Orleans, 1996, several innovative practices reduced Reliability Centered Maintenance costs while maintaining the accuracy of the analysis. The optimization strategy has undergone further evolution and at the present an Integrated Maintenance Program (IMP) is in place where an Expert Panel consisting of all players/experts proceed through each system in a disciplined fashion and reach agreement on all items under a rigorous time frame. It is well known that there are essentially 3 maintenance based actions that can flow from a Maintenance Optimization Analysis: condition based maintenance, time based maintenance and time based discard. The present effort deals with time based discard decisions. Maintenance data from the Remote On-Power Fuel Changing System was used. (author)

Explorability and predictability of the paleozoic sedimentary sequence beneath the Bruce nuclear site

International Nuclear Information System (INIS)

Parmenter, A.; Jensen, M.; Crowe, R.; Raven, K.

2011-01-01

Ontario Power Generation (OPG) is proposing to develop a Deep Geologic Repository (DGR) for the long-term management of its Low and Intermediate Level Waste (L&ILW) at the Bruce nuclear site located in the Municipality of Kincardine, Ontario. A 4-year program of geoscientific studies to assess the suitability of the 850 m thick Palaeozoic age sedimentary sequence beneath the site to host the DGR was completed in 2010. The studies provide evidence of a geologic setting in which the DGR concept would be safely implemented at a nominal depth of 680 m within the argillaceous limestone of the Cobourg Formation. This paper describes the geologic framework of the Bruce nuclear site with a focus on illustrating the high degree of stratigraphic continuity and traceability at site-specific and regional scales within the Ordovician sediments proposed to host and enclose the DGR. As part of the site-specific studies, a program of deep drilling/coring (6 boreholes) and in-situ testing through the sedimentary sequence was completed from 4 drill sites situated beyond the DGR footprint, approximately 1 km apart. Core logging reveals that the stratigraphic sequence comprises 34 distinct bedrock formations/members/units consistent with the known regional stratigraphic framework. These layered sedimentary formations dip 0.6 o (~10 m/km) to the southwest with highly uniform thicknesses both at the site- and regional-scale, particularly, the Ordovician sediments, which vary on the order of metres. The occurrence of steeply-dipping faults within the sedimentary sequence is not revealed through surface outcrop fracture mapping, micro-seismic (M ≥ 1) monitoring, inclined borehole coring or intersection of hydrothermal type dolomitized reservoir systems. Potential fault structures, interpreted from a 2-D seismic survey, were targeted by angled boreholes which found no evidence for their existence. Formation specific continuity is also evidence by the lateral traceability of physical rock

Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169

Science.gov (United States)

Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

2018-01-01

Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3–6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0–4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications. PMID:29293588

Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169.

Science.gov (United States)

Lyman, Mathew; Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

2018-01-01

Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3-6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0-4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications.

78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

Science.gov (United States)

2013-08-05

... Green, Jr., M.D., 59 FR 51,453 (DEA 1994); David E. Trawick, D.D.S., 53 FR 5,326 (DEA 1988). Here, the...) (ten years); Norman Alpert, M.D., 58 FR 67,420, 67,421 (DEA 1993) (seven years). Here, the conditions...

Summary of Session 4 'Strategy for 2012 (II)'

International Nuclear Information System (INIS)

Bruning, Oliver; Ponce, Laurette

2012-01-01

The fourth session of the 2012 LHC Performance Workshop included the following presentations: • Beam Energy by Andrzej Siemko; • Optics Options by Massimo Giovannozzi; • Collimation settings and performance by Roderik Bruce; • Performance Reach in the LHC for 2012 by Gianluigi Arduini; • MD plans in 2012 by Ralph Wolfgang Assmann; • Ions in 2012 by John Jowett

Summary of Session 4 'Strategy for 2012 (II)'

Energy Technology Data Exchange (ETDEWEB)

Bruning, Oliver; Ponce, Laurette [European Organization for Nuclear Research, Geneva (Switzerland)

2012-07-01

The fourth session of the 2012 LHC Performance Workshop included the following presentations: • Beam Energy by Andrzej Siemko; • Optics Options by Massimo Giovannozzi; • Collimation settings and performance by Roderik Bruce; • Performance Reach in the LHC for 2012 by Gianluigi Arduini; • MD plans in 2012 by Ralph Wolfgang Assmann; • Ions in 2012 by John Jowett.

White spots on Smoke rings by Bruce Nauman: a case study on contemporary art conservation using microanalytical techniques.

Science.gov (United States)

Mafalda, Ana Cardeira; da Câmara, Rodrigo Bettencourt; Strzelec, Patrick; Schiavon, Nick; Mirão, José; Candeias, António; Carvalho, Maria Luísa; Manso, Marta

2015-02-01

The artwork "Smoke Rings: Two Concentric Tunnels, Non-Communicating" by Bruce Nauman represents a case study of corrosion of a black patina-coated Al-alloy contemporary artwork. The main concern over this artwork was the widespread presence of white spots on its surface. Alloy substrate, patina, and white spots were characterized by means of energy-dispersive X-ray fluorescence and scanning electron microscopy with energy-dispersive spectroscopy. Alloy substrate was identified as an aluminum alloy 6,000 series Al-Si-Mg. Patina's identified composition confirmed the documentation provided by the atelier. Concerning the white spots, zircon particles were found on patina surface as external elements.

Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

Directory of Open Access Journals (Sweden)

Jianping AN

2017-03-01

Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

BayesMD: flexible biological modeling for motif discovery

DEFF Research Database (Denmark)

Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

2008-01-01

We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

International Nuclear Information System (INIS)

Ohto, Umeharu; Satow, Yoshinori

2008-01-01

Twinned crystals of humaan MD-2 are transformed into single crystals with cryoprotectant optimization. Twinning of crystals causes overlapping of two or more reciprocal lattice points, and hence structure amplitudes for a single crystalline domain are hardly obtained from X-ray diffraction intensities. MD-2 protein forms a stable complex with Toll-like receptor 4 and recognizes bacterial lipopolysaccharide (LPS). Excessive immune responses activated by LPS cause septic shocks. Saccharide-trimmed human MD-2 crystallizes in the tetragonal form with apparent Laue symmetry of 4/mmm, and diffraction intensities from these crystals indicate crystal twinning. The crystal consists of two different domains, A and B. The c A axis of domain A coincides with the c B axis of domain B with a smaller lattice, and the a A axis corresponds to the (a B + b B ) axis. This twinning severely imposes difficulty in structure determination. Through optimization of cryoprotectant, domain A was thoroughly transformed into domain B. The crystal containing only domain B is in space group P4 1 2 1 2 with one MD-2 molecule in the asymmetric unit. The structure of this form of MD-2 as well as its complex with antiendotoxic lipid IVa was successfully determined using the multiple isomorphous replacement method

MD on UFOs at MKIs and MKQs

CERN Document Server

Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

2012-01-01

UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

Science.gov (United States)

Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

2014-04-01

This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

Center of excellence for mobile sensor data-to-knowledge (MD2K).

Science.gov (United States)

Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

2015-11-01

Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

MdHB1 down-regulation activates anthocyanin biosynthesis in the white-fleshed apple cultivar 'Granny Smith'.

Science.gov (United States)

Jiang, Yonghua; Liu, Cuihua; Yan, Dan; Wen, Xiaohong; Liu, Yanli; Wang, Haojie; Dai, Jieyu; Zhang, Yujie; Liu, Yanfei; Zhou, Bin; Ren, Xiaolin

2017-02-01

Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple). Moreover, flowers of transgenic tobacco (Nicotiana tabacum 'NC89') overexpressing MdHB1 showed a remarkable reduction in pigmentation. Transient promoter activation assays and yeast one-hybrid results indicated that MdHB1 indirectly inhibited expression of the anthocyanin biosynthetic genes encoding dihydroflavonol-4-reductase (DFR) and UDP-glucose:flavonoid 3-O-glycosyltransferase (UFGT). Yeast two-hybrid and bimolecular fluorescence complementation determined that MdHB1 acted as a homodimer and could interact with MYB, bHLH, and WD40 in the cytoplasm, consistent with its cytoplasmic localization by green fluorescent protein fluorescence observations. Together, these results suggest that MdHB1 constrains MdMYB10, MdbHLH3, and MdTTG1 to the cytoplasm, and then represses the transcription of MdDFR and MdUFGT indirectly. When MdHB1 is silenced, these TFs are released to activate the expression of MdDFR and MdUFGT and also anthocyanin biosynthesis, resulting in red flesh in 'Granny Smith'. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

The hydration enthalpies of Md3+ and Lr3+

International Nuclear Information System (INIS)

Bruechle, W.; Schaedel, M.; Scherer, U.W.; Kratz, J.V.

1987-10-01

Lawrencium (3-min 260 Lr) and lighter actinides were produced in the bombardement of a 249 Bk target with 18 O ions and loaded onto a cation exchange column in 0.05 M α-hydroxy-isobutyrate solution at pH = 4.85 together with the radioactive lanthanide tracers 166 Ho, 171 Er, and 171 Tm. In elutions with 0.12 M α-hydroxy-isobutyrate solution (pH = 4.85) trivalent Lr was eluted exactly together with the Er tracer and Md close to Ho. Lr elutes much later than expected based on the known elution positions of the lighter actinides and the expected analogy to the elution positions of the homologous lanthanides. From the measured elution positions, ionic radii were calculated for Lr 3+ and Md 3+ . Semiempirical models allow the calculation of the heat of hydration from the ionic radii, resulting in ΔH hyd ≅ - 3654 kJ/mol for Md 3+ and ΔH hyd ≅ - 3689 kJ/mol for Lr 3+ . (orig.)

Characterization and dissolution studies of Bruce Unit 3 steam generator secondary side deposits

International Nuclear Information System (INIS)

Semmler, J.

1998-01-01

The physical and chemical properties of secondary side steam generator deposits in the form of powder and flake obtained from Bruce Nuclear Generating Station A (BNGS A) Unit 3 were studied. The chemical phases present in both types of deposits, collected prior to the 1994 chemical cleaning during the pre-clean water lancing campaign, were magnetite (Fe 3 O 4 ), metallic copper (Cu), hematite (Fe 2 O 3 ) and cuprous oxide (Cu 2 O). The major difference between the chemical composition of the powder and the flake was the presence of zinc silicate (Zn 2 SiO 4 ) and several unidentified silicate phases containing Ca, Al, Mn, and Mg in the flake. The flake deposit had high hardness values, high electrical resistivity, low porosity and a lower dissolution rate in the EPRI-SGOG (Electric Power Research Institute-Steam Generator Owner's Group) chemical cleaning solvents compared to the powder deposit. Differences in the deposit properties after chemical cleaning of the Unit 3 steam generators and after laboratory cleaning were noted. The presence of silicates in the deposit inhibit magnetite dissolution

76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

Science.gov (United States)

2011-12-29

... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to... five hours advance notice is given. The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke...

The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

Science.gov (United States)

Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

2017-05-01

MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

International Nuclear Information System (INIS)

Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

2014-01-01

We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors

PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

Energy Technology Data Exchange (ETDEWEB)

Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

2014-09-01

We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

MD#2183: Calibration of the IR6 B2 diamond BLMs

CERN Document Server

Valette, Matthieu; Lindstrom, Bjorn Hans Filip

2018-01-01

In case of an asynchronous beam dump with a fully filled LHC machine, causing ~40 bunches to impact on the movable dump protection absorber (TCDQ), it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IR6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the TCDQ downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with a dynamic range of several orders of magnitude; thus, allowing to derive the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. During this first MD only the Beam 1 dBLM was calibrated appropriately, a second calibration MD was therefore performed in 2017 for the B2 system. Results from this MD and conclusions regarding dBLM saturation with a top energy nominal...

Draft Environmental Impact Statement: Peacekeeper Rail Garrison Program

Science.gov (United States)

1988-06-01

Patricia Haldorsen, Senior Technical Editor, Tetra Tech, Inc. B.A., 1982, English Literature, California State University, San Bernardino Years of...Thierry, Word Processing Supervisor, Tetra Tech, Inc. Years of Experience: 6 Patricia A. Turnham, Publications Manager, Tetra Tech, Inc. A.A., 1974...Breiner Mark Barnhard Sharon Breitweiser Barrry J. Barnhart Charles R. Brevik James R. Barr Ronald Brimberry, M.D. Bruce D. Barry Barbara Brinkley Tad

MD2036: UFO Dynamics Studies and UFO Fast Detection

CERN Document Server

Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

2017-01-01

UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

Science.gov (United States)

Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

2018-02-01

Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

STRATEGI PEMASARAN PUBLIC RELATIONS MD ENTERTAINMENT PADA PEMASARAN FILM HABIBIE & AINUN

OpenAIRE

Trisna Adi Permana; Lilis Puspitasari

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategi Marketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun 2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematis fakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitian menunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik...

MD 2179: Scraping of off-momentum halo after injection

CERN Document Server

Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

2018-01-01

In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

InforMD: a new initiative to raise public awareness about breast density.

Science.gov (United States)

Hugo, Honor J; Zysk, Aneta; Dasari, Pallave; Britt, Kara; Hopper, John L; Stone, Jennifer; Thompson, Erik W; Ingman, Wendy V

2018-01-01

On a mammogram, breast density (also known as mammographic density) is shown as white and bright regions and is associated with reduced sensitivity in cancer detection and increased breast cancer risk. However, many Australian women are unaware of the significance of breast density as it is not routinely reported or discussed. In order to address this lack of knowledge, Australian breast cancer researchers with expertise in mammographic density formed the InforMD alliance (INformation FORum on Mammographic Density) in 2016. The alliance is working to raise awareness of breast density with the goal of improving breast cancer diagnosis and health outcomes for women. The InforMD website (www.InforMD.org.au) was launched in October 2016, coinciding with a major nationwide public awareness campaign by the alliance during breast cancer awareness month. The website contains unbiased, accurate, updated information on breast density. The website also provides summaries of major research articles in layperson language, recent news items related to breast density, links to relevant information for health professionals, events, and feature articles. Members of the public and health professionals can also subscribe for news updates. The interactive online Forum section facilitates discussion between health professionals, scientists and members of the public. To increase online traffic to the website, Facebook (www.facebook.com/BeInforMD) and Twitter (https://twitter.com/BeInforMD_) pages were launched in December 2016. Since its launch, InforMD has generated considerable interest. The public awareness campaign reached over 7 million Australians through a combination of newspaper, TV, radio, and online news. The website has attracted 13,058 unique visitors and 30,353 page views (data as of 19/12/2017). Breast cancer researchers have a significant role to play in disseminating information to the public on breast density. A combination of mainstream and social media, together with

An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis.

Science.gov (United States)

Bai, Songling; Saito, Takanori; Honda, Chikako; Hatsuyama, Yoshimichi; Ito, Akiko; Moriguchi, Takaya

2014-11-01

Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Arabidopsis PAP1 is under the control of a series of upstream factors involved in light signal transduction and photomorphogenesis, such as ELONGATED HYPOCOTYL 5 (HY5) and B-box family (BBX) proteins. In this study, we identified and characterized the homolog of Arabidopsis BBX22 in apple, designated as MdCOL11. Overexpression of MdCOL11 in Arabidopsis enhanced the accumulation of anthocyanin. In apples, MdCOL11 was differentially expressed in all tissues, with the highest expression in petals and the lowest expression in the xylem. Transcripts of MdCOL11 noticeably accumulated at the ripening stage, concomitant with increases in the expressions of anthocyanin biosynthesis-related genes. In an in vitro treatment experiment, MdCOL11 was upregulated in an ultra-violet (UV)-B- and temperature-dependent manner, together with the inductions of anthocyanin biosynthesis-related genes and anthocyanin accumulation in apple peel. Furthermore, a dual-luciferase assay indicated that (1) MdCOL11 regulated the expression of MdMYBA and (2) MdCOL11 was a target of MdHY5. Taken together, our results suggest that MdCOL11 is involved in MdHY5-mediated signal transduction and regulates anthocyanin accumulation in apple peel, which sheds new light on anthocyanin accumulation in apples.

Strategi Pemasaran Public Relations Md Entertainment Pada Pemasaran Film Habibie & Ainun

OpenAIRE

Permana, Trisna Adi; Puspitasari, Lilis

2015-01-01

Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategiMarketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematisfakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitianmenunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik PR pada film Ha...

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).

Science.gov (United States)

Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

2017-03-21

Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2 -/- mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases.

Image fusion in craniofacial virtual reality modeling based on CT and 3dMD photogrammetry.

Science.gov (United States)

Xin, Pengfei; Yu, Hongbo; Cheng, Huanchong; Shen, Shunyao; Shen, Steve G F

2013-09-01

The aim of this study was to demonstrate the feasibility of building a craniofacial virtual reality model by image fusion of 3-dimensional (3D) CT models and 3 dMD stereophotogrammetric facial surface. A CT scan and stereophotography were performed. The 3D CT models were reconstructed by Materialise Mimics software, and the stereophotogrammetric facial surface was reconstructed by 3 dMD patient software. All 3D CT models were exported as Stereo Lithography file format, and the 3 dMD model was exported as Virtual Reality Modeling Language file format. Image registration and fusion were performed in Mimics software. Genetic algorithm was used for precise image fusion alignment with minimum error. The 3D CT models and the 3 dMD stereophotogrammetric facial surface were finally merged into a single file and displayed using Deep Exploration software. Errors between the CT soft tissue model and 3 dMD facial surface were also analyzed. Virtual model based on CT-3 dMD image fusion clearly showed the photorealistic face and bone structures. Image registration errors in virtual face are mainly located in bilateral cheeks and eyeballs, and the errors are more than 1.5 mm. However, the image fusion of whole point cloud sets of CT and 3 dMD is acceptable with a minimum error that is less than 1 mm. The ease of use and high reliability of CT-3 dMD image fusion allows the 3D virtual head to be an accurate, realistic, and widespread tool, and has a great benefit to virtual face model.

Identity as Fleeting Fashion? Revealing the Background of Popularity Through Bosniaherzegovina’s Adoption of Bruce Lee

Directory of Open Access Journals (Sweden)

Alenka Bartulović

2007-12-01

Full Text Available This paper reflects on the background to popular research on identification processes in modern ethnology and cultural or social anthropology. By discussing themes closely connected to identity (national and popular culture, and the construction of Others, the author reveals that identity is not merely a redundant trend that researchers recklessly pursue, but that it reflects the need to reveal existing uncertainties and is an attempt to revise errors made to date, as well as lapses of the discipline we work in. The author primarily focuses on national identity and its situational transformations and intertwining with other existing identities. Bosnia-Herzegovina is placed at the center of interest. This theoretically oriented text concludes by analyzing the idea of erecting a monument to Bruce Lee in Mostar, which reveals the full complexity of identity processes around a world marked by intense and unique global and transnational currents.

Monitoring the risk of loss of heat sink during plant shutdowns at Bruce Generating Station 'A'

International Nuclear Information System (INIS)

Krishnan, K.S.; Mancuso, F.; Vecchiarelli, D.

1996-01-01

A relatively simple loss of shutdown heat sink fault tree model has been developed and used during unit outages at Bruce Nuclear Generation Station 'A' to assess, from a risk and reliability perspective, alternative heat sink strategies and to aid in decisions on allowable outage configurations. The model is adjusted to reflect the various unit configurations planned during a specific outage, and identifies events and event combinations leading to loss of fuel cooling. The calculated failure frequencies are compared to the limits consistent with corporate and international public safety goals. The importance measures generated by the interrogation of the fault tree model for each outage configuration are also used to reschedule configurations with high fuel damage frequency later into the outage and to control the configurations with relatively high probability of fuel damage to short intervals at the most appropriate time into the outage. (author)

StandsSIM-MD: a Management Driven forest SIMulator

Directory of Open Access Journals (Sweden)

Susana Barreiro

2016-07-01

Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1

Energy Technology Data Exchange (ETDEWEB)

Yoon, Sung-il; Hong, Minsun; Wilson, Ian A [Scripps

2011-11-16

RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homolog TLR4-MD-2 but assembles into an unusual 2:2 homodimer that differs from any other known TLR-ligand assembly. The homodimer is assembled in a head-to-head orientation that juxtaposes the N-terminal leucine-rich repeats (LRRs) of the two RP105 chains, rather than the usual tail-to-tail configuration of C-terminal LRRs in ligand-activated TLR dimers, such as TLR1-TRL2, TLR2-TLR6, TLR3-TLR3 and TLR4-TLR4. Another unusual interaction is mediated by an RP105-specific asparagine-linked glycan, which wedges MD-1 into the co-receptor binding concavity on RP105. This unique mode of assembly represents a new paradigm for TLR complexes and suggests a molecular mechanism for regulating LPS responses.

Find an Orthopaedic Foot and Ankle MD/DO

Science.gov (United States)

... All Site Content AOFAS / FootCareMD / Find a Surgeon Find a Foot & Ankle Orthopaedic Surgeon Page Content Who ... your prescribed treatment (surgical and/or non-surgical) ​ Find a Surgeon ​ Click here to find a foot ...

Molecular cloning and functional analysis of a blue light receptor gene MdCRY2 from apple (Malus domestica).

Science.gov (United States)

Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Rui-Fen; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

2013-04-01

MdCRY2 was isolated from apple fruit skin, and its function was analyzed in MdCRY2 transgenic Arabidopsis. The interaction between MdCRY2 and AtCOP1 was found by yeast two-hybrid and BiFC assays. Cryptochromes are blue/ultraviolet-A (UV-A) light receptors involved in regulating various aspects of plant growth and development. Investigations of the structure and functions of cryptochromes in plants have largely focused on Arabidopsis (Arabidopsis thaliana), tomato (Solanum lycopersicum), pea (Pisum sativum), and rice (Oryza sativa). However, no data on the function of CRY2 are available in woody plants. In this study, we isolated a cryptochrome gene, MdCRY2, from apple (Malus domestica). The deduced amino acid sequences of MdCRY2 contain the conserved N-terminal photolyase-related domain and the flavin adenine dinucleotide (FAD) binding domain, as well as the C-terminal DQXVP-acidic-STAES (DAS) domain. Relationship analysis indicates that MdCRY2 shows the highest similarity to the strawberry FvCRY protein. The expression of MdCRY2 is induced by blue/UV-A light, which represents a 48-h circadian rhythm. To investigate the function of MdCRY2, we overexpressed the MdCRY2 gene in a cry2 mutant and wild type (WT) Arabidopsis, assessed the phenotypes of the resulting transgenic plants, and found that MdCRY2 functions to regulate hypocotyl elongation, root growth, flower initiation, and anthocyanin accumulation. Furthermore, we examined the interaction between MdCRY2 and AtCOP1 using a yeast two-hybrid assay and a bimolecular fluorescence complementation assay. These data provide functional evidence for a role of blue/UV-A light-induced MdCRY2 in controlling photomorphogenesis in apple.

Dolomitized bryozoan bioherms from the Lower Silurian Manitoulin Formation, Bruce Peninsula, Ontario

Energy Technology Data Exchange (ETDEWEB)

Anastas, A S; Coniglo, M [Waterloo Univ., ON (Canada)

1992-06-01

Several small, previously undescribed bioherms are present in the shallow shelf dolostones of the Manitoulin Formation at the Cabot Head and Wingfield Basin localities in the northernmost portion of the Bruce Peninsula region of southern Ontario. The bioherms, commonly associated with carbonate tempestites, range from 0.3 to 1.0 m in height and 0.9 to 2.5 m in width and are composed of bafflestones-floatstones and minor bindstones. The chief components of the bioherms are dolomitized lime mud and branching bryozoans. Bioherm building by bryozoans, although common in the ancient record, represents a great divergence from the mostly accessory frame encrusting role of bryozoans in modern environments. Minor skeletal components of the bioherms include echinoderms, rugose and tabulate corals and brachiopods. Laminar encrusting bryozoans exist in the top 10 cm of one of the bioherms. Some of the bioherms show evidence of water agitation that may be the result of current action induced by storm or tidal processes. The occurrence of the bioherms stretches the already known Llandoverian reef complex on Manitoulin Island further to the south. The reason why these bioherms did not reach sizes comparable to large Llandoverian or Wenlockian reefs and did not make the shift to coral-stromaporoid community is probably related to a complex interaction of factors such as community development, bathymetry, clasticity and salinity. 41 refs., 4 figs.

MD2725: 16L2 aperture measurement

CERN Document Server

Mirarchi, Daniele; Rossi, Roberto; CERN. Geneva. ATS Department

2018-01-01

Dumps induced by sudden increase of losses in the half-cell 16L2 have been a serious machine limitation during the 2017 run. The aim of this MD was to perform local aperture measurements in order to assess differences after the beam screen regeneration, compared to first measurements in 2017.

Possibilities of production of neutron-rich Md isotopes in multi-nucleon transfer reactions

Energy Technology Data Exchange (ETDEWEB)

Mun, Myeong-Hwan; Lee, Young-Ouk [Korea Atomic Energy Research Institue, Daejeon (Korea, Republic of); Adamian, G.G.; Antonenko, N.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation)

2016-12-15

The possibilities of production of yet unknown neutron-rich isotopes of Md are explored in several multi-nucleon transfer reactions with actinide targets and stable and radioactive beams. The projectile-target combinations and bombarding energies are suggested to produce new neutron-rich isotopes of Md in future experiments. (orig.)

Water at silica/liquid water interfaces investigated by DFT-MD simulations

Science.gov (United States)

Gaigeot, Marie-Pierre

This talk is dedicated to probing the microscopic structural organization of water at silica/liquid water interfaces including electrolytes by first principles DFT-based molecular dynamics simulations (DFT-MD). We will present our very recent DFT-MD simulations of electrolytic (KCl, NaCl, NaI) silica/liquid water interfaces in order to unravel the intertwined structural properties of water and electrolytes at the crystalline quartz/liquid water and amorphous silica/liquid water interfaces. DFT-MD simulations provide direct knowledge of the structural organization of water and the H-Bond network formed between the water molecules within the different water layers above the silica surface. One can furthermore extract vibrational signatures of the water molecules within the interfacial layers from the DFT-MD simulations, especially non-linear SFG (Sum Frequency generation) signatures that are active at solid/liquid interfaces. The strength of the simulated spectra is that a detailed analysis of the signatures in terms of the water/water H-Bond networks formed within the interfacial water layers and in terms of the water/silica or water/electrolytes H-Bond networks can be given. Comparisons of SFG spectra between quartz/water/electrolytes and amorphous silica/water/electrolytes interfaces allow us to definitely conclude on how the structural arrangements of liquid water at these electrolytic interfaces modulate the final spectroscopic signatures. Invited speaker.

The dew point response of the annulus gas system of Bruce NGS A

International Nuclear Information System (INIS)

Kenchington, J.; Ellis, P.J.; Meranda, D.

1983-01-01

The dew point response of the Annulus Gas System in Bruce A, Units 1 and 2 has been modelled in order to alert the operator of the presence of heavy water and to estimate the leak rate into the annulus. The computer model can be easily adapted to determine the Annulus Gas System dew point response in any station. It models the complex arrangement of the system and the transportation of moisture through the annuli by a combination of plug flow and mixing of CO 2 and D 2 O vapor. It predicts the response of the dew point monitor for a range of specified leak rates and positions of a leaking channel in a string of channels. This model has been used to calculate the variation of dew point and rate of change of dew point with respect to time (t). It shows that there is a maximum in the rate of dew point change (dT/dt) with respect to the corresponding dew point (T). This maximum is unique for a given leak rate and channel position. It is independent of the starting time for the leak. The computer programme has been verified by an analytical solution for the model

Usefulness of multidetector-row computed tomography (MD-CT) for diagnosis and evaluation of cardiovascular anomalies in infants

International Nuclear Information System (INIS)

Kani, Hiroyuki; Narabayashi, Isamu; Tanikake, Masato; Matsuki, Mitsuru; Uesugi, Yasuo

2005-01-01

We examined the effectiveness of multidetector-row CT (MD-CT) in the diagnosis and evaluation of cardiovascular anomalies in infants. MD-CT was performed 34 times on 21 patients with cardiovascular anomalies. We performed three evaluations: 1) The assessment of the specificity of MD-CT in detecting the morphological features of cardiovascular anomalies. 2) The diameters of aortae with coronary artery (CoA), and the diameters of pulmonary artery, measured by using MD-CT were compared with those by angiography. 3) The amount of exposure to radiation was measured. 1) MD-CT can detect CoA, pulmonary arteriovenous anomalies among extracardiac anomalies in all the patients. The diagnostic accuracy for intracardiac anomalies was poor as only six of the 15 anomalies could be accurately diagnosed. 2) The diameters of aortae and pulmonary artery obtained using MD-CT showed a good correlation with those obtained using arteriography (r=0.97, 0.95). 3) The average dose-length product was 269.2 mGy·cm. And the average effective dose was 5.1 mSv. MD-CT is not suitable for the evaluation of intracardiac anomalies, but is extremely effective in the evaluation of extracardiac major vascular anomalies. On the basis of the amount of information and noninvasive nature, MD-CT should be used first before angiography. (author)

Phytotoxicology section investigation in the vicinity of the Bruce Nuclear Power Development, the Pickering Nuclear Generating Station and the Darlington Nuclear Generating Station, in October, 1989

International Nuclear Information System (INIS)

1991-02-01

The Phytotoxicology Section, Air Resources Branch is a participant in the Pickering and Bruce Nuclear Contingency Plans. The Phytotoxicology Emergency Response Team is responsible for collecting vegetation samples in the event of a nuclear emergency at any of the nuclear generating stations in the province. As part of its responsibility the Phytotoxicology Section collects samples around the nuclear generating stations for comparison purposes in the event of an emergency. Because of the limited frequency of sampling, the data from the surveys are not intended to be used as part of a regulatory monitoring program. These data represent an effort by the MOE to begin to establish a data base of tritium concentrations in vegetation. The Phytotoxicology Section has carried out seven surveys in the vicinity of Ontario Hydro nuclear generating stations since 1981. Surveys were conducted for tritium in snow in the vicinity of Bruce Nuclear Power Development (BNPD), February, 1981; tritium in cell-free water of white ash in the vicinity of BNPD, September, 1981; tritium in snow in the vicinity of BNPD, March, 1982; tritium in tree sap in the vicinity of BNPD, April, 1982; tritium in tree sap in the vicinity of BNPD, April, 1984, tritium in the cell-free water of white ash in the vicinity of BNPD, September, 1985; and, tritium in cell-free water of grass in the vicinity of Pickering Nuclear Generation Station (PNGS), October 1986. In all cases a pattern of decreasing tritium levels with increasing distance from the stations was observed. In October, 1989, assessment surveys were conducted around Bruce Nuclear Power Development, the Pickering Nuclear Generating Station and the new Darlington Nuclear Generating Station (DNGS). The purpose of these surveys was to provide baseline data for tritium in cell-free water of grass at all three locations at the same time of year. As none of the reactor units at DNGS had been brought on line at the time of the survey, this data was to be

An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

Directory of Open Access Journals (Sweden)

Jagdish Prasad Agrawal

2013-09-01

Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

KAUST Repository

Han, Gang

2015-05-20

A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

Overexpression of a repressor MdMYB15L negatively regulates anthocyanin and cold tolerance in red-fleshed callus.

Science.gov (United States)

Xu, Haifeng; Yang, Guanxian; Zhang, Jing; Wang, Yicheng; Zhang, Tianliang; Wang, Nan; Jiang, Shenghui; Zhang, Zongying; Chen, Xuesen

2018-04-14

The cold-induced metabolic pathway and anthocyanin biosynthesis play important roles in plant growth. In this study, we identified a bHLH binding motif in the MdMYB15L protein using protein sequence analyses. Yeast two-hybrid and pull-down assays showed that MdMYB15L could interact with MdbHLH33. Overexpressing MdMYB15L in red-fleshed callus inhibited the expression of MdCBF2 and resulted in reduced cold tolerance but did not affect anthocyanin levels. Chip-PCR and EMSA analysis showed that MdMYB15L could bind the type II cis-acting element found in the MdCBF2 promoter. Overexpressing MdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Knocking out the bHLH binding sequence of MdMYB15L (LBSMdMYB15L) prevented LBSMdMYB15L from interacting with MdbHLH33. Overexpressing LBSMdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Together, these results suggested that an apple repressor MdMYB15L might play a key role in the cold signaling and anthocyanin metabolic pathways. Copyright © 2018 Elsevier Inc. All rights reserved.

Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.

Science.gov (United States)

Dulay, Antonette T; Buhimschi, Catalin S; Zhao, Guomao; Oliver, Emily A; Abdel-Razeq, Sonya S; Shook, Lydia L; Bahtiyar, Mert O; Buhimschi, Irina A

2015-06-01

TLR4 mediates host responses to pathogens through a mechanism that involves protein myeloid differentiation-2 (MD-2) and its soluble form sMD-2. The role of sMD2 in intra-amniotic inflammation-induced preterm birth has not been previously explored. Human amniotic fluid (AF) sMD-2 was studied by Western blotting in 152 AF samples of patients who had an amniocentesis to rule-out infection (yes infection, n = 50; no infection, n = 50) or women with normal pregnancy outcome (second trimester genetic karyotyping, n = 26; third trimester lung maturity testing, n = 26). Histological localization and mRNA expression of MD2 in fetal membranes were studied by immunohistochemistry and RT-PCR. The ability of fetal membrane to release sMD-2 and inflammatory cytokines was studied in vitro. Human AF contains three sMD-2 proteoforms whose levels of expression were lower at term. Intra-amniotic infection upregulated sMD-2. MD-2 mRNA and immunohistochemistry findings concurred. In vitro, LPS and monensin increased, while cycloheximide decreased sMD-2 production. Recombinant sMD-2 modulated TNF-α and IL-6 levels in a dose- and time-dependent fashion. sMD2 proteoforms are constitutively present in human AF. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 ligands may be facilitated through synthesis and release of sMD2 by the amniochorion. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Thomas Secker M.D.: Archbishop and man-midwife.

Science.gov (United States)

Morgan-Guy, John

2018-05-01

This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Directory of Open Access Journals (Sweden)

Adeline M Hajjar

Full Text Available Although lipopolysaccharide (LPS stimulation through the Toll-like receptor (TLR-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

Science.gov (United States)

Hajjar, Adeline M; Ernst, Robert K; Fortuno, Edgardo S; Brasfield, Alicia S; Yam, Cathy S; Newlon, Lindsay A; Kollmann, Tobias R; Miller, Samuel I; Wilson, Christopher B

2012-01-01

Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

76 FR 15214 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2011-03-21

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... for Marine Events; Potomac River, Charles County, MD'' in the Federal Register (76 FR 1381). We... follows: Sec. 100.35-T05-1113 Special Local Regulations for Marine Events; Potomac River, Charles County...

76 FR 1381 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2011-01-10

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... Regulations for Marine Events; Potomac River, Charles County, MD. (a) Regulated area. The following location... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

CERN Document Server

Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

2015-01-01

The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

The Human Dimension of Networks

Science.gov (United States)

2008-06-01

Networking Organizational Issues Authors: Bruce J. West Ph.D. Army Research Office Elizabeth K. Bowman Ph.D. Army Research Laboratory – Human...Contact: Elizabeth K.Bowman AMSRD-ARL-HR Bulding 459, Aberdeen Proving Ground, MD 21005 410-278-5924 EBowman@arl.army.mil 1 Report Documentation Page...L.E. Brus , Nature 383, 802 (1996); M. Kuno, D.P. Fromim, s.R. Hohmson, A. Gallagher and D.J. Nesbitt, Phys. Rev. B 67, 125304 (2003); K.R. Shimizu

StandsSIM-MD: a Management Driven forest SIMulator

Energy Technology Data Exchange (ETDEWEB)

Barreiro, S.; Rua, J.; Tomé, M.

2016-07-01

Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

Effect of salinity and temperature on treatment of concentrated wastewater from RO by FO-MD

Science.gov (United States)

Zhou, Yingru; Huang, Manhong; Deng, Qian

2018-02-01

In this study the appropriate temperature of the membrane distillation (MD) hot side (the permeation flux of MD was controlled by adjusting the hot side temperature) was selected according to the water flux of FO process so that the water transfer rate on both sides of FO and MD was consistent and the FO-MD process could be stable operation. When the salt concentration of feed solution was 30, 55, 80 and 100 g/L, the desalination rates changed little, which were 99.1%, 98.4%, 98.9% and 98.7%, respectively. The removal rate of COD was 93.8%, 94.2%, 91.6% and 92.7% which also changed little like the desalination rates. The removal rate of chromaticity increased with the increase of salinity, which attained 96.6%, 97.0%, 97.2% and 97.9%, respectively. This study proved that salinity of the feed solution affected little on the removal rate of contaminants but great on the water flux, with the increase of salinity from 30 to 100 g/L, the water flux was 6.05, 4.81, 4.33 and 3.87 LMH with the appropriate temperature (67.5±0.5, 64.5±0.5, 62.5±0.5 and 60.5±0.5 °C) of MD hot side. In a word, FO-MD was first used to treat the high salinity RO water with over 30 g/L total dissolved solids (TDS), FO-MD was a promising new process for high salinity wastewater treatment, and the hybrid system can solve the problem of lower draw solution concentration, and the high-quality production water will be obtained directly by this hybrid system with low membrane fouling tendency.

Volume reduction/solidification of liquid radioactive waste using bitumen at Ontario Hydro's Bruce Nuclear Generating Station 'A'

International Nuclear Information System (INIS)

Day, J.E.; Baker, R.L.

1995-01-01

Ontario Hydro at the Bruce Nuclear Generating Station 'A' has undertaken a program to render the station's liquid radioactive waste suitable for discharge to Lake Huron by removing sufficient radiological and chemical contaminants to satisfy regulatory requirements for emissions. The system will remove radionuclide and chemical contaminants from five different plant waste streams. The contaminants will be immobilized and stored at on-site radioactive waste storage facilities and the purified streams will be discharged. The discharge targets established by Ontario Hydro are set well below the limits established by the Ontario Ministry of Environment (MOE) and are based on the Best Available Technology Economically Achievable Approach (B.A.T.E.A.). ADTECHS Corporation has been selected by Ontario Hydro to provide volume reduction/solidification technology for one of the five waste streams. The system will dry and immobilize the contaminants from a liquid waste stream in emulsified asphalt using thin film evaporation technology

77 FR 6708 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

Science.gov (United States)

2012-02-09

...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... River, Charles County, MD. (a) Regulated area. The following location is a regulated area: All waters of... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey.

Science.gov (United States)

Badyal, Dinesh K; Daniel, Sujit R

2016-10-01

To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level.

Review of 40-year MD theses in Medical Oncology

International Nuclear Information System (INIS)

Zeeneldin, A.; Diyaa, A.; Elgammal, M.; Buhoush, W.; Manar Moneer, M.

2014-01-01

Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

Top of tubesheet cracking in Bruce A NGS steam generator tubing - recent experience

International Nuclear Information System (INIS)

Clark, M.A.; Lepik, O.; Mirzai, M.; Thompson, I.

1998-01-01

During the Bruce A Nuclear Generating Station (BNGS-A) Unit 1 1997 planned outage, a dew point search method identified a leak in one steam generator(SG) tube. Subsequently, the tube was inspected with all available eddy current probes and removed for examination. The initial inspection results and metallurgical examination of the removed tube confirmed that the leak was due to intergranular attack/stress corrosion cracking (IGA/SCC) emanating from the secondary side of the tube at the top of the tubesheet location. Subsequently, eddy current and ultrasonic indications were found at the top of the tubesheet of other Alloy 600 SG tubes. To investigate the source of the indications and to validate the inspection probes, sections of 40 tubes with various levels of damage were removed. The metallurgical examination of the removed sections showed that both secondary side and primary side initiated, circumferential, stress corrosion cracking and intergranular attack occurred in the BNGS-A SG tubing. Significant degradation from both mechanisms was found, invariably located in the roll transition region of the top expansion joint between the tube and the tubesheet on the hot leg (304 degrees C) side of the tube. Various aspects of the failures and tube examinations are presented in this paper, including presentation of the cracking morphology, measured crack size distributions, and discussion of some factors possibly affecting the cracking. (author)

75 FR 76688 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

Science.gov (United States)

2010-12-09

..., mile 0.5, at Ocean City, with a vertical clearance of 13 feet above mean high tide in the closed...-AA09 Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast... Ocean City, MD. This proposed rule will require any mariner requesting an opening in the evening hours...

MD Test of a Ballistic Optics

CERN Document Server

Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

2016-01-01

The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

MD/MBA programs in the United States: evidence of a change in health care leadership.

Science.gov (United States)

Larson, David B; Chandler, Maria; Forman, Howard P

2003-03-01

Managerial sciences are playing an increasingly prominent role in the organization and delivery of health care. Despite popular media reports that a rising number of physicians are acquiring a background in this discipline through MD/MBA (medical and master of business administration) programs, no recent study has verified this. This study measured changes in the number and nature of the affiliations between management and medicine in the form of MD/MBA programs in the United States. Surveys of admission officers of 125 U.S. allopathic medical schools and of the overseers of each joint MD/MBA degree program were administered in May-October 2001. Main outcome measures included program growth, curriculum and degree requirements, application and admission requirements, and program leadership and organization. The number of MD/MBA programs grew from six to 33 between 1993 and 2001, and 17 more medical schools were considering establishing the joint-degree program. Ten, 15, and 20 programs produced 27, 42, and 61 graduates in 1999, 2000, and 2001, respectively, and over 100 students were expected to graduate per year when all 33 programs matured. Program structures and oversight indicate a spectrum of philosophies regarding the appropriate level of integration of the two degrees. MD/MBA programs apparently attempt to complement medical education with management education rather than the converse. The growth in the numbers of MD/MBA programs and participants indicates rising cooperation between medical and business schools and increasing interest in management education early in the careers of graduating physicians.

MD210 Note: Creation of Hollow Bunches in the PSB

CERN Document Server

Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

2016-01-01

MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

JST Thesaurus Headwords and Synonyms: Md [MeCab user dictionary for science technology term[Archive

Lifescience Database Archive (English)

Full Text Available MeCab user dictionary for science technology term Md 名詞 一般 * * * * メンデレビウム メンデレビウム メンデレビューム Thesaurus2015 200906022783221535 C CA03 UNKNOWN_1 Md

Review of 40-year MD theses in medical oncology.

Science.gov (United States)

Zeeneldin, Ahmed; Diyaa, Amira; Moneer, Manar; Elgammal, Mosaad; Buhoush, Wafa

2014-09-01

It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70's-80's period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design. Copyright © 2014. Production and hosting by Elsevier B.V.

Economic and humanistic burden of post-trauma and post-surgical neuropathic pain among adults in the United States

OpenAIRE

Sadosky, Alesia; Parsons,Bruce; Schaefer,Caroline; Mann,Rachael; Daniel,Shoshana; Nalamachu,Srinivas; Stacey,Brett R; Nieshoff,Edward C; Tuchman,Michael; Anschel,Alan

2013-01-01

Bruce Parsons,1 Caroline Schaefer,2 Rachael Mann,3 Alesia Sadosky,1 Shoshana Daniel,4 Srinivas Nalamachu,5 Brett R Stacey,6 Edward C Nieshoff,7 Michael Tuchman,8 Alan Anschel91Pfizer, Inc, New York, NY, USA; 2Covance Market Access Services, Inc, Gaithersburg, MD, USA; 3Covance Market Access Services, Inc, San Diego, CA, USA; 4Covance Market Access Services, Inc, Conshohocken, PA, USA; 5International Clinical Research Institute, Overland Park, KS, USA; 6Oregon Health and Science University, Po...

North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury: A Consortium of Military, Veterans Administration, and Civilian Hospitals

Science.gov (United States)

2011-01-31

Robert Grossman MD PI-Main 20 Susan Howley Admin 21.65 Peter Wilderotter Admin 1.5 Edward Jobst Admin 4.25 Anne Homa Admin 9 Bruce Morgan thru 12/31...re qu ir ed H ow t o te st Se ns ib ili ty d om ai n: t es t si te s se le ct ed b y de rm at om e L ig ht to uc h/ SW M 33 6 pa lm ar /d

75 FR 8193 - Jeri Hassman, M.D.; Denial of Application

Science.gov (United States)

2010-02-23

... is buying drugs on the street. Id. at 1006. With respect to requests for early refills, Dr. Hare... Part II Department of Justice Drug Enforcement Administration Jeri Hassman, M.D.; Denial of...; [[Page 8194

Preliminary post-closure safety assessment of repository concepts for low level radioactive waste at the Bruce Site, Ontario

International Nuclear Information System (INIS)

Little, R.H.; Penfold, J.S.S.; Egan, M.J.; Leung, H.

2005-01-01

The preliminary post-closure safety assessment of permanent repository concepts for low-level radioactive waste (LLW) at the Ontario Power Generation (OPG) Bruce Site is described. The study considered the disposal of both short and long-lived LLW. Four geotechnically feasible repository concepts were considered (two near-surface and two deep repositories). An approach consistent with best international practice was used to provide a reasoned and comprehensive analysis of post-closure impacts of the repository concepts. The results demonstrated that the deep repository concepts in shale and in limestone, and the surface repository concept on sand should meet radiological protection criteria. For the surface repository concept on glacial till, it appears that increased engineering such as grouting of waste and voids should be considered to meet the relevant dose constraint. Should the project to develop a permanent repository for LLW proceed, it is expected that this preliminary safety assessment would need to be updated to take account of future site-specific investigations and design updates. (author)

MD-portal: Highly Effective Website for Nuclear Materials Information Management

International Nuclear Information System (INIS)

Kil, Soyeon; Lee, Gyeonggeun; Kwon, Junhyun

2014-01-01

A web-based system is widespread in not only everyday activities but also business fields. In past years, the systematic information of various properties of materials usually has been provided as tabulated documents; however it recently has been provided as web-based DB. There are many websites providing material properties information, representative examples include MatWeb from the United States, Granta MI from England and MatNavi from Japan. In 2003, the nuclear materials division in KAERI established a website about nuclear materials property DB, called MatDB. To inherit it, a website called MD-portal has been recently set up to release degradation information and various properties of nuclear materials. In this presentation, the structure and characteristics of MD-portal will be mentioned, and comments on its application will be given

The Structural Basis for Lipid and Endotoxin Binding in RP105-MD-1, and Consequences for Regulation of Host Lipopolysaccharide Sensitivity.

Science.gov (United States)

Ortiz-Suarez, Maite L; Bond, Peter J

2016-01-05

MD-1 is a member of the MD-2-related lipid-recognition (ML) family, and associates with RP105, a cell-surface protein that resembles Toll-like receptor 4 (TLR4). The RP105⋅MD-1 complex has been proposed to play a role in fine-tuning the innate immune response to endotoxin such as bacterial lipopolysaccharide (LPS) via TLR4⋅MD-2, but controversy surrounds its mechanism. We have used atomically detailed simulations to reveal the structural basis for ligand binding and consequent functional dynamics of MD-1 and the RP105 complex. We rationalize reports of endogenous phospholipid binding, by showing that they prevent collapse of the malleable MD-1 fold, before refining crystallographic models and uncovering likely binding modes for LPS analogs. Subsequent binding affinity calculations reveal that endotoxin specificity arises from the entropic cost of expanding the MD-1 cavity to accommodate bulky lipid tails, and support the role of MD-1 as a "sink" that sequesters endotoxin from TLR4 and stabilizes RP105/TLR4 interactions. Copyright © 2016 Elsevier Ltd. All rights reserved.

MD and BCA simulations of He and H bombardment of fuzz in bcc elements

Science.gov (United States)

Klaver, T. P. C.; Zhang, S.; Nordlund, K.

2017-08-01

We present results of MD simulations of low energy He ion bombardment of low density fuzz in bcc elements. He ions can penetrate several micrometers into sparse fuzz, which allows for a sufficient He flux through it to grow the fuzz further. He kinetic energy falls off exponentially with penetration depth. A BCA code was used to carry out the same ion bombardment on the same fuzz structures as in MD simulations, but with simpler, 10 million times faster calculations. Despite the poor theoretical basis of the BCA at low ion energies, and the use of somewhat different potentials in MD and BCA calculations, the ion penetration depths predicted by BCA are only ∼12% less than those predicted by MD. The MD-BCA differences are highly systematic and trends in the results of the two methods are very similar. We have carried out more than 200 BCA calculation runs of ion bombardment of fuzz, in which parameters in the ion bombardment process were varied. For most parameters, the results show that the ion bombardment process is quite generic. The ion species (He or H), ion mass, fuzz element (W, Ta, Mo, Fe) and fuzz element lattice parameter turned out to have a modest influence on ion penetration depths at most. An off-normal angle of incidence strongly reduces the ion penetration depth. Increasing the ion energy increases the ion penetration, but the rate by which ion energy drops off at high ion energies follows the same exponential pattern as at lower energies.

Postgraduate research training: the PhD and MD thesis.

Science.gov (United States)

Higginson, I; Corner, J

1996-04-01

Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study.

Science.gov (United States)

Tourbah, Ayman; Lebrun-Frenay, Christine; Edan, Gilles; Clanet, Michel; Papeix, Caroline; Vukusic, Sandra; De Sèze, Jerome; Debouverie, Marc; Gout, Olivier; Clavelou, Pierre; Defer, Gilles; Laplaud, David-Axel; Moreau, Thibault; Labauge, Pierre; Brochet, Bruno; Sedel, Frédéric; Pelletier, Jean

2016-11-01

Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients. The primary endpoint was the proportion of patients with disability reversal at month 9, confirmed at month 12, defined as an EDSS decrease of ⩾1 point (⩾0.5 for EDSS 6-7) or a ⩾20% decrease in timed 25-foot walk time compared with the best baseline among screening or randomisation visits. A total of 13 (12.6%) MD1003-treated patients achieved the primary endpoint versus none of the placebo-treated patients (p = 0.005). MD1003 treatment also reduced EDSS progression and improved clinical impression of change compared with placebo. Efficacy was maintained over follow-up, and the safety profile of MD1003 was similar to that of placebo. MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated. © The Author(s), 2016.

The mycorrhiza-dependent defensin MtDefMd1 of Medicago truncatula acts during the late restructuring stages of arbuscule-containing cells.

Directory of Open Access Journals (Sweden)

Marian Uhe

Full Text Available Different symbiotic and pathogenic plant-microbe interactions involve the production of cysteine-rich antimicrobial defensins. In Medicago truncatula, the expression of four MtDefMd genes, encoding arbuscular mycorrhiza-dependent defensins containing an N-terminal signal peptide and exhibiting some differences to non-symbiotic defensins, raised over the time of fungal colonization. Whereas the MtDefMd1 and MtDefMd2 promoters were inactive in cells containing young arbuscules, cells with fully developed arbuscules displayed different levels of promoter activities, indicating an up-regulation towards later stages of arbuscule formation. MtDefMd1 and MtDefMd2 expression was absent or strongly down-regulated in mycorrhized ram1-1 and pt4-2 mutants, known for defects in arbuscule branching or premature arbuscule degeneration, respectively. A ~97% knock-down of MtDefMd1/MtDefMd2 expression did not significantly affect arbuscule size. Although overexpression of MtDefMd1 in arbuscule-containing cells led to an up-regulation of MtRam1, encoding a key transcriptional regulator of arbuscule formation, no morphological changes were evident. Co-localization of an MtDefMd1-mGFP6 fusion with additional, subcellular markers revealed that this defensin is associated with arbuscules in later stages of their life-cycle. MtDefMd1-mGFP6 was detected in cells with older arbuscules about to collapse, and ultimately in vacuolar compartments. Comparisons with mycorrhized roots expressing a tonoplast marker indicated that MtDefMd1 acts during late restructuring processes of arbuscule-containing cells, upon their transition into a post-symbiotic state.

MD 349: Impedance Localization with AC-dipole

CERN Document Server

Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2016-01-01

The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

MD and FFM Electron Broadening for Warm and Dense Hydrogen Plasmas

International Nuclear Information System (INIS)

Ferri, S.; Calisti, A.; Mosse, C.; Talin, B.; Gonzalez, M. A.; Gigosos, M. A.

2006-01-01

Direct integration of the semi-classical evolution equation based on Molecular Dynamics simulations (MD) and the Frequency Fluctuation Model (FFM) have long been used to synthesize spectra accounting for ion dynamics. Cross comparisons of these approaches generally show results in good agreement. Recently, interest in low temperature (Te ∼ 1eV) and high density (Ne ∼ 1018 cm-3) hydrogen plasma spectroscopy has motivated extended applications of FFM. Arising discrepancies were found to originate in electron collision operators suggesting an improper use of impact approximations for warm and dense plasma conditions. In order to clarify this point, new useful cross comparisons between MD and FFM have been carried out for electron broadening

Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice.

Science.gov (United States)

Hattori, Tatsuya; Osakada, Takuya; Masaoka, Takuto; Ooyama, Rumi; Horio, Nao; Mogi, Kazutaka; Nagasawa, Miho; Haga-Yamanaka, Sachiko; Touhara, Kazushige; Kikusui, Takefumi

2017-10-23

The Bruce effect refers to pregnancy termination in recently pregnant female rodents upon exposure to unfamiliar males [1]. This event occurs in specific combinations of laboratory mouse strains via the vomeronasal system [2, 3]; however, the responsible chemosensory signals have not been fully identified. Here we demonstrate that the male pheromone exocrine gland-secreting peptide 1 (ESP1) is one of the key factors that causes pregnancy block. Female mice exhibited high pregnancy failure rates upon encountering males that secreted different levels of ESP1 compared to the mated male. The effect was not observed in mice that lacked the ESP1 receptor, V2Rp5, which is expressed in vomeronasal sensory neurons. Prolactin surges in the blood after mating, which are essential for maintaining luteal function, were suppressed by ESP1 exposure, suggesting that a neuroendocrine mechanism underlies ESP1-mediated pregnancy failure. The single peptide pheromone ESP1 conveys not only maleness to promote female receptivity but also the males' characteristics to facilitate memorization of the mating partner. Copyright © 2017 Elsevier Ltd. All rights reserved.

Volume reduction/solidification of liquid radioactive waste using bitumen at Ontario hydro's Bruce nuclear generating station open-quotes Aclose quotes

International Nuclear Information System (INIS)

Day, J.E.; Baker, R.L.

1994-01-01

Ontario Hydro at the Bruce Nuclear Generating Station open-quotes Aclose quotes has undertaken a program to render the station's liquid radioactive waste suitable for discharge to Lake Huron by removing sufficient radiological and chemical contaminants from five different plant waste streams. The contaminants will be immobilized and stored at on-site radioactive waste storage facilities and the purified streams will be discharged. The discharge targets established by Ontario Hydro are set well below the limits established by the Ontario Ministry of Environment (MOE) and are based on the Best Available Technology Economically Achievable Approach (B.A.T.E.A.). ADTECHS Corporation has been selected by Ontario Hydro to provide volume reduction/solidification technology for one of the five waste streams. The system will dry and immobilize the contaminants from a liquid waste stream in emulsified asphalt using thin film evaporation technology

Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

Directory of Open Access Journals (Sweden)

Aruna Rajan

2010-04-01

Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

Validation of DRAGON side-step method for Bruce-A restart Phase-B physics tests

International Nuclear Information System (INIS)

Shen, W.; Ngo-Trong, C.; Davis, R.S.

2004-01-01

The DRAGON side-step method, developed at AECL, has a number of advantages over the all-DRAGON method that was used before. It is now the qualified method for reactivity-device calculations. Although the side-step-method-generated incremental cross sections have been validated against those previously calculated with the all-DRAGON method, it is highly desirable to validate the side-step method against device-worth measurements in power reactors directly. In this paper, the DRAGON side-step method was validated by comparison with the device-calibration measurements made in Bruce-A NGS Unit 4 restart Phase-B commissioning in 2003. The validation exercise showed excellent results, with the DRAGON code overestimating the measured ZCR worth by ∼5%. A sensitivity study was also performed in this paper to assess the effect of various DRAGON modelling techniques on the incremental cross sections. The assessment shows that the refinement of meshes in 3-D and the use of the side-step method are two major reasons contributing to the improved agreement between the calculated ZCR worths and the measurements. Use of different DRAGON versions, DRAGON libraries, local-parameter core conditions, and weighting techniques for the homogenization of tube clusters inside the ZCR have a very small effect on the ZCR incremental thermal absorption cross section and ZCR reactivity worth. (author)

[Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

Science.gov (United States)

Mydlík, M; Derzsiová, K

2010-11-01

Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

Applicability of effective fragment potential version 2 - Molecular dynamics (EFP2-MD) simulations for predicting excess properties of mixed solvents

Science.gov (United States)

Kuroki, Nahoko; Mori, Hirotoshi

2018-02-01

Effective fragment potential version 2 - molecular dynamics (EFP2-MD) simulations, where the EFP2 is a polarizable force field based on ab initio electronic structure calculations were applied to water-methanol binary mixture. Comparing EFP2s defined with (aug-)cc-pVXZ (X = D,T) basis sets, it was found that large sets are necessary to generate sufficiently accurate EFP2 for predicting mixture properties. It was shown that EFP2-MD could predict the excess molar volume. Since the computational cost of EFP2-MD are far less than ab initio MD, the results presented herein demonstrate that EFP2-MD is promising for predicting physicochemical properties of novel mixed solvents.

The knock-down of the expression of MdMLO19 reduces susceptibility to powdery mildew (Podosphaera leucotricha) in apple (Malus domestica).

Science.gov (United States)

Pessina, Stefano; Angeli, Dario; Martens, Stefan; Visser, Richard G F; Bai, Yuling; Salamini, Francesco; Velasco, Riccardo; Schouten, Henk J; Malnoy, Mickael

2016-10-01

Varieties resistant to powdery mildew (PM; caused by Podosphaera leucotricha) are a major component of sustainable apple production. Resistance can be achieved by knocking-out susceptibility S-genes to be singled out among members of the MLO (Mildew Locus O) gene family. Candidates are MLO S-genes of phylogenetic clade V up-regulated upon PM inoculation, such as MdMLO11 and 19 (clade V) and MdMLO18 (clade VII). We report the knock-down through RNA interference of MdMLO11 and 19, as well as the complementation of resistance with MdMLO18 in the Arabidopsis thaliana triple mlo mutant Atmlo2/6/12. The knock-down of MdMLO19 reduced PM disease severity by 75%, whereas the knock-down of MdMLO11, alone or in combination with MdMLO19, did not result in any reduction or additional reduction of susceptibility compared with MdMLO19 alone. The test in A. thaliana excluded a role for MdMLO18 in PM susceptibility. Cell wall appositions (papillae) were present in both PM-resistant and PM-susceptible plants, but were larger in resistant lines. No obvious negative phenotype was observed in plants with mlo genes knocked down. Apparently, MdMLO19 plays the pivotal role in apple PM susceptibility and its knock-down induces a very significant level of resistance. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

The draft genome of MD-2 pineapple using hybrid error correction of long reads

Science.gov (United States)

Redwan, Raimi M.; Saidin, Akzam; Kumar, S. Vijay

2016-01-01

The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. PMID:27374615

MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

CERN Document Server

Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

2017-01-01

During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

MD-CTS: An integrated terminology reference of clinical and translational medicine

Directory of Open Access Journals (Sweden)

Will Ray

2016-01-01

Full Text Available New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS. It is the first public resource that comprehensively integrates Wiktionary (word definition, BioPortal (ontology, Wiki (image reference, and Medline abstract (word usage information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95% than paper-based dictionaries (57–71%.

First-year seminar intervention: Enhancing first- year mathematics ...

African Journals Online (AJOL)

year Seminar and the mathematics performance of first-year students in Science? .... generation students enter the new higher education environment (Briggs, Clark ..... institution-wide approaches to enact the FYE as “everybody's business”.

MD1878: Operation with primary collimators at tighter settings

CERN Document Server

AUTHOR|(CDS)2078850; Amorim, David; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

2017-01-01

Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

A workshop on leadership for senior MD-PhD students.

Science.gov (United States)

Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

2016-01-01

Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students.

Combination of advanced encryption standard 256 bits with md5 to secure documents on android smartphone

Science.gov (United States)

Pasaribu, Hendra; Sitanggang, Delima; Rizki Damanik, Rudolfo; Rudianto Sitompul, Alex Chandra

2018-04-01

File transfer by using a smartphone has some security issues like data theft by irresponsible parties. To improve the quality of data security systems on smartphones, in this research the integration of AES 256 bit algorithm by using MD5 hashing is proposed. The use of MD5 aims to increase the key strength of the encryption and decryption process of document files. The test results show that the proposed method can increase the key strength of the encryption and decryption process in the document file. Encryption and decryption time by using AES and MD5 combination is faster than using AES only on *.txt file type and reverse results for *.docx, *.xlsx, *.pptx and *.pdf file files.

An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

KAUST Repository

Liang, Tengfei

2013-01-01

Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

Science.gov (United States)

Keogh, Timothy J.; Martin, William Marty

2011-01-01

The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells

International Nuclear Information System (INIS)

Schnabl, Bernd; Brandl, Katharina; Fink, Marina; Gross, Philipp; Taura, Kojiro; Gaebele, Erwin; Hellerbrand, Claus; Falk, Werner

2008-01-01

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. In injured liver they are the main extracellular matrix protein producing cell type and further perpetuate hepatic injury by secretion of pro-inflammatory mediators. Since LPS-mediated signaling through toll-like receptor 4 (TLR4) has been identified as key fibrogenic signal in HSCs we aimed to test TLR4 as potential target of therapy via ligand-binding soluble receptors. Incubation of human HSCs with a fusion protein between the extracellular domain of TLR4 and MD2 which binds LPS inhibited LPS-induced NFκB and JNK activation. TLR4/MD2 abolished LPS-induced secretion of IL-6, IL-8, MCP1, and RANTES in HSCs. In addition, TLR4/MD2 fused to human IgG-Fc neutralized LPS activity. Since TLR4 mutant mice are resistant to liver fibrosis, the TLR4/MD2 soluble receptor might represent a new therapeutic molecule for liver fibrogenesis in vivo

Review of Ontario Hydro Pickering 'A' and Bruce 'A' nuclear generating stations' accident analyses

International Nuclear Information System (INIS)

Serdula, K.J.

1988-01-01

Deterministic safety analysis for the Pickering 'A' and Bruce 'A' nuclear generating stations were reviewed. The methodology used in the evaluation and assessment was based on the concept of 'N' critical parameters defining an N-dimensional safety parameter space. The reviewed accident analyses were evaluated and assessed based on their demonstrated safety coverage for credible values and trajectories of the critical parameters within this N-dimensional safety parameter space. The reported assessment did not consider probability of occurrence of event. The reviewed analyses were extensive for potential occurrence of accidents under normal steady-state operating conditions. These analyses demonstrated an adequate assurance of safety for the analyzed conditions. However, even for these reactor conditions, items have been identified for consideration of review and/or further study, which would provide a greater assurance of safety in the event of an accident. Accident analyses based on a plant in a normal transient operating state or in an off-normal condition but within the allowable operating envelope are not as extensive. Improvements in demonstrations and/or justifications of safety upon potential occurrence of accidents would provide further assurance of adequacy of safety under these conditions. Some events under these conditions have not been analyzed because of their judged low probability; however, accident analyses in this area should be considered. Recommendations are presented relating to these items; it is also recommended that further study is needed of the Pickering 'A' special safety systems

Wettability of graphitic-carbon and silicon surfaces: MD modeling and theoretical analysis

International Nuclear Information System (INIS)

Ramos-Alvarado, Bladimir; Kumar, Satish; Peterson, G. P.

2015-01-01

The wettability of graphitic carbon and silicon surfaces was numerically and theoretically investigated. A multi-response method has been developed for the analysis of conventional molecular dynamics (MD) simulations of droplets wettability. The contact angle and indicators of the quality of the computations are tracked as a function of the data sets analyzed over time. This method of analysis allows accurate calculations of the contact angle obtained from the MD simulations. Analytical models were also developed for the calculation of the work of adhesion using the mean-field theory, accounting for the interfacial entropy changes. A calibration method is proposed to provide better predictions of the respective contact angles under different solid-liquid interaction potentials. Estimations of the binding energy between a water monomer and graphite match those previously reported. In addition, a breakdown in the relationship between the binding energy and the contact angle was observed. The macroscopic contact angles obtained from the MD simulations were found to match those predicted by the mean-field model for graphite under different wettability conditions, as well as the contact angles of Si(100) and Si(111) surfaces. Finally, an assessment of the effect of the Lennard-Jones cutoff radius was conducted to provide guidelines for future comparisons between numerical simulations and analytical models of wettability

An apple MYB transcription factor, MdMYB3, is involved in regulation of anthocyanin biosynthesis and flower development.

Science.gov (United States)

Vimolmangkang, Sornkanok; Han, Yuepeng; Wei, Guochao; Korban, Schuyler S

2013-11-07

Red coloration of fruit is an important trait in apple, and it is mainly attributed to the accumulation of anthocyanins, a class of plant flavonoid metabolites. Anthocyanin biosynthesis is genetically determined by structural and regulatory genes. Plant tissue pigmentation patterns are mainly controlled by expression profiles of regulatory genes. Among these regulatory genes are MYB transcription factors (TFs), wherein the class of two-repeats (R2R3) is deemed the largest, and these are associated with the anthocyanin biosynthesis pathway. Although three MdMYB genes, almost identical in nucleotide sequences, have been identified in apple, it is likely that there are other R2R3 MYB TFs that are present in the apple genome that are also involved in the regulation of coloration of red color pigmentation of the skin of apple fruits. In this study, a novel R2R3 MYB gene has been isolated and characterized in apple. This MYB gene is closely related to the Arabidopsis thaliana AtMYB3, and has been designated as MdMYB3. This TF belongs to the subgroup 4 R2R3 family of plant MYB transcription factors. This apple MdMYB3 gene is mapped onto linkage group 15 of the integrated apple genetic map. Transcripts of MdMYB3 are detected in all analyzed tissues including leaves, flowers, and fruits. However, transcripts of MdMYB3 are higher in excocarp of red-skinned apple cultivars than that in yellowish-green skinned apple cultivars. When this gene is ectopically expressed in Nicotiana tabacum cv. Petite Havana SR1, flowers of transgenic tobacco lines carrying MdMYB3 have exhibited increased pigmentation and accumulate higher levels of anthocyanins and flavonols than wild-type flowers. Overexpression of MdMYB3 has resulted in transcriptional activation of several flavonoid pathway genes, including CHS, CHI, UFGT, and FLS. Moreover, peduncles of flowers and styles of pistils of transgenic plants overexpressing MdMYB3 are longer than those of wild-type plants, thus suggesting that this

Towards automatic coupling corrections with DOROS BPMs (MD750)

CERN Document Server

Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2015-01-01

BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

Science.gov (United States)

2010-07-01

... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin and...

Flux distribution measurements in the Bruce B Unit 6 reactor using a transportable traveling flux detector system

International Nuclear Information System (INIS)

Leung, T.C.; Drewell, N.H.; Hall, D.S.; Lopez, A.M.

1987-01-01

A transportable traveling flux detector (TFD) system for use in power reactors has been developed and tested at Chalk River Nuclear Labs. in Canada. It consists of a miniature fission chamber, a motor drive mechanism, a computerized control unit, and a data acquisition subsystem. The TFD system was initially designed for the in situ calibration of fixed self-powered detectors in operating power reactors and for flux measurements to verify reactor physics calculations. However, this system can also be used as a general diagnostic tool for the investigation of apparent detector failures and flux anomalies and to determine the movement of reactor internal components. This paper describes the first successful use of the computerized TFD system in an operating Canada deuterium uranium (CANDU) power reactor and the results obtained from the flux distribution measurements. An attempt is made to correlate minima in the flux profile with the locations of fuel channels so that future measurements can be used to determine the sag of the channels. Twenty-seven in-core flux detector assemblies in the 855-MW (electric) Unit 6 reactor of the Ontario Hydro Bruce B Generating Station were scanned

76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

Science.gov (United States)

2011-08-19

...-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone during the ``NAS Patuxent River... held over certain waters of the Patuxent River adjacent to Patuxent River, Maryland from September 1...

Cavity Voltage Phase Modulation MD

CERN Document Server

Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

2016-01-01

The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

Verina Morton Jones, MD.

Science.gov (United States)

Rishworth, Susan K

2012-01-01

The purpose of this historical article is to demonstrate, as the biography of Verina Morton Jones, MD, is uncovered, the difficulties inherent in researching original source material on the lives of 19th- and early 20th-century African American physicians as well as the great benefits derived from doing this research. The procedures used include basic archival research and close examination of published materials about her in the past, in conjunction with oral history. Original correspondence from Dr Morton Jones to her niece and nephew is used to illustrate events in her life and the thoughts and attitudes she expressed. Some of these thoughts and attitudes reflect those current situations in which African Americans found themselves, and others are quite unique, no doubt owing to her privileged position in the African American community. The principle conclusions reached include the great benefits derived from doing this kind of research, as difficult and time-consuming as that may be, with the enhanced knowledge and appreciation of the heritage of African American physicians, and insights into American social history during this period.

ADT fast losses MD

CERN Document Server

Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

2013-01-01

The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

CERN Document Server

AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

2017-01-01

The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lip...opolysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

Future plans for performance analysis and maintenance/inspection optimization of shutoff rods based on the case study of Bruce Power Unit-3 Shutoff Rod 5 inspection

International Nuclear Information System (INIS)

Nasimi, E.; Gabbar, H.A.

2011-01-01

Shutdown System 1 (SDS1) is a preferred method for a quick shutdown of nuclear fission process in CANDU (CANada Deuterium Uranium) reactor units. Failure of a routine SDS1 safety test during Fall 2009 outage resulted in the need to develop and execute a new methodology for Shutoff Rod inspection and re-evaluate the known degradation mechanisms and failure modes. This paper describes the development of this methodology and the obtained results. It also proposes several alternative solutions for the future performance analysis and maintenance/inspection optimization for SDS1 Shutoff Rods based on the Bruce Power Unit-3 Shutoff Rod 5 case study. (author)

Full-Scale Crash Test of an MD-500 Helicopter

Science.gov (United States)

Littell, Justin

2011-01-01

A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

Science.gov (United States)

2011-04-11

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-25] Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy Assistant Administrator, Office of Diversion... constitutional right to appointed counsel in a proceeding under 21 U.S.C. 824(a). See Goldberg v. Kelly, 397 U.S...

Criticality safety issues associated with the introduction of low void reactivity fuel in the Bruce reactors - a management and technical overview

International Nuclear Information System (INIS)

Thompson, J.W.; Austman, G.; Iglesias, F.; Schmeing, H.; Elliott, C.; Archinoff, G.

2004-01-01

The concept of criticality for operating reactor staff, particularly in a natural uranium-fuelled reactor, is relatively benign - the reactor is controlled at the critical condition by the regulating system. That is, issues related to criticality exist only within the reactor, in a set of carefully managed circumstances. With the introduction of enriched Low Void Reactivity Fuel (LVRF) into this operating environment comes a new 'concept of criticality', one which, although physically the same, cannot be treated in the same fashion. It may be the case that criticality can be achieved outside the reactor, albeit with a set of very pessimistic assumptions. Such 'inadvertent criticality' outside the reactor, should it occur, cannot be controlled. The consequences of such an inadvertent criticality could have far-reaching effects, not only in terms of severe health effects to those nearby, but also in terms of the negative impact on Bruce Power, and the Canadian nuclear industry in general. Thus the introduction of LVRF in the Bruce B reactors, and therefore the introduction of this new hazard, inadvertent criticality, warrants the development of a governance structure for its management. Such a program will consist of various elements, including the establishment of a framework to administer the criticality safety program, analytical assessment to support the process design, the development of operational procedures, the development of enhanced emergency procedures if necessary, and the implementation of a criticality safety training program. The entire package must be sufficient to demonstrate to station management, and the regulator, that the criticality safety risks associated with the implementation of enriched fuel have been properly evaluated, and that all necessary steps have been taken to effectively manage these risks. A well-founded Criticality Safety Program will offer such assurance. In this paper, we describe the establishment of a Criticality Safety

In-situ Air Temperature and Relative Humidity in Greenbelt, MD, 2013-2015

Data.gov (United States)

National Aeronautics and Space Administration — This data set describes the temperature and relative humidity at 12 locations around Goddard Space Flight Center in Greenbelt MD at 15 minute intervals between...

Metabolic engineering of apple by overexpression of the MdMyb10 gene

Directory of Open Access Journals (Sweden)

Khaled A.L. Rihani

2017-06-01

In the present study, the flavonoid pathway was successfully modified in apple by overexpressing the MdMyb10 transcription factor to validate the hypothesis of increased effect on plant disease resistance.

76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations.

Science.gov (United States)

Scheurer, Maximilian; Rodenkirch, Peter; Siggel, Marc; Bernardi, Rafael C; Schulten, Klaus; Tajkhorshid, Emad; Rudack, Till

2018-02-06

Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences. The size and model complexity of MD simulations are rapidly growing along with increasing computing power and improved algorithms. This growth has led to the production of a large amount of simulation data that need to be filtered for relevant information to address specific biomedical and biochemical questions. One of the most relevant molecular properties that can be investigated by all-atom MD simulations is the time-dependent evolution of the complex noncovalent interaction networks governing such fundamental aspects as molecular recognition, binding strength, and mechanical and structural stability. Extracting, evaluating, and visualizing noncovalent interactions is a key task in the daily work of structural biologists. We have developed PyContact, an easy-to-use, highly flexible, and intuitive graphical user interface-based application, designed to provide a toolkit to investigate biomolecular interactions in MD trajectories. PyContact is designed to facilitate this task by enabling identification of relevant noncovalent interactions in a comprehensible manner. The implementation of PyContact as a standalone application enables rapid analysis and data visualization without any additional programming requirements, and also preserves full in-program customization and extension capabilities for advanced users. The statistical analysis representation is interactively combined with full mapping of the results on the molecular system through the synergistic connection between PyContact and VMD. We showcase the capabilities and scientific significance of PyContact by analyzing and visualizing in great detail the noncovalent interactions underlying the ion permeation pathway of the human P2X 3 receptor. As a second application, we examine the protein-protein interaction network of the mechanically ultrastable cohesin-dockering complex. Copyright © 2017 Biophysical Society

A dsRNA-binding protein MdDRB1 associated with miRNA biogenesis modifies adventitious rooting and tree architecture in apple.

Science.gov (United States)

You, Chun-Xiang; Zhao, Qiang; Wang, Xiao-Fei; Xie, Xing-Bin; Feng, Xiao-Ming; Zhao, Ling-Ling; Shu, Huai-Rui; Hao, Yu-Jin

2014-02-01

Although numerous miRNAs have been already isolated from fruit trees, knowledge about miRNA biogenesis is largely unknown in fruit trees. Double-strand RNA-binding (DRB) protein plays an important role in miRNA processing and maturation; however, its role in the regulation of economically important traits is not clear yet in fruit trees. EST blast and RACE amplification were performed to isolate apple MdDRB1 gene. Following expression analysis, RNA binding and protein interaction assays, MdDRB1 was transformed into apple callus and in vitro tissue cultures to characterize the functions of MdDRB1 in miRNA biogenesis, adventitious rooting, leaf development and tree growth habit. MdDRB1 contained two highly conserved DRB domains. Its transcripts existed in all tissues tested and are induced by hormones. It bound to double-strand RNAs and interacted with AtDCL1 (Dicer-Like 1) and MdDCL1. Chip assay indicated its role in miRNA biogenesis. Transgenic analysis showed that MdDRB1 controls adventitious rooting, leaf curvature and tree architecture by modulating the accumulation of miRNAs and the transcript levels of miRNA target genes. Our results demonstrated that MdDRB1 functions in the miRNA biogenesis in a conserved way and that it is a master regulator in the formation of economically important traits in fruit trees. © 2013 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

A comparative study of Message Digest 5(MD5) and SHA256 algorithm

Science.gov (United States)

Rachmawati, D.; Tarigan, J. T.; Ginting, A. B. C.

2018-03-01

The document is a collection of written or printed data containing information. The more rapid advancement of technology, the integrity of a document should be kept. Because of the nature of an open document means the document contents can be read and modified by many parties so that the integrity of the information as a content of the document is not preserved. To maintain the integrity of the data, it needs to create a mechanism which is called a digital signature. A digital signature is a specific code which is generated from the function of producing a digital signature. One of the algorithms that used to create the digital signature is a hash function. There are many hash functions. Two of them are message digest 5 (MD5) and SHA256. Those both algorithms certainly have its advantages and disadvantages of each. The purpose of this research is to determine the algorithm which is better. The parameters which used to compare that two algorithms are the running time and complexity. The research results obtained from the complexity of the Algorithms MD5 and SHA256 is the same, i.e., ⊖ (N), but regarding the speed is obtained that MD5 is better compared to SHA256.

75 FR 24774 - Fairmount Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-05-05

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-36 OTS Nos. 08193 and H4677] Fairmount Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on April 15, 2010, the Office of Thrift Supervision approved the application of Fairmount Bank, Baltimore, Maryland, to...

76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

Science.gov (United States)

2011-10-20

...-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD AGENCY: Coast Guard, DHS. ACTION... regulation. The Baltimore County Revenue Authority (Dundalk Avenue) highway toll drawbridge across Bear Creek... applicable or necessary. Basis and Purpose The drawbridge across Bear Creek, mile 1.5 was removed and...

A Comparison of the American Society of Cataract and Refractive Surgery post-myopic LASIK/PRK Intraocular Lens (IOL calculator and the Ocular MD IOL calculator

Directory of Open Access Journals (Sweden)

Hsu M

2011-09-01

Full Text Available David L DeMill1, Majid Moshirfar1, Marcus C Neuffer1, Maylon Hsu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USABackground: To compare the average values of the American Society of Cataract and Refractive Surgery (ASCRS and Ocular MD intraocular lens (IOL calculators to assess their accuracy in predicting IOL power in patients with prior laser-in-situ keratomileusis (LASIK or photorefractive keratectomy.Methods: In this retrospective study, data from 21 eyes with previous LASIK or photorefractive keratectomy for myopia and subsequent cataract surgery was used in an IOL calculator comparison. The predicted IOL powers of the Ocular MD SRK/T, Ocular MD Haigis, and ASCRS averages were compared. The Ocular MD average (composed of an average of Ocular MD SRK/T and Ocular MD Haigis and the all calculator average (composed of an average of Ocular MD SRK/T, Ocular MD Haigis, and ASCRS were also compared. Primary outcome measures were mean arithmetic and absolute IOL prediction error, variance in mean arithmetic IOL prediction error, and the percentage of eyes within ±0.50 and ±1.00 D.Results: The Ocular MD SRK/T and Ocular MD Haigis averages produced mean arithmetic IOL prediction errors of 0.57 and –0.61 diopters (D, respectively, which were significantly larger than errors from the ASCRS, Ocular MD, and all calculator averages (0.11, –0.02, and 0.02 D, respectively, all P < 0.05. There was no statistically significant difference between the methods in absolute IOL prediction error, variance, or the percentage of eyes with outcomes within ±0.50 and ±1.00 D.Conclusion: The ASCRS average was more accurate in predicting IOL power than the Ocular MD SRK/T and Ocular MD Haigis averages alone. Our methods using combinations of these averages which, when compared with the individual averages, showed a trend of decreased mean arithmetic IOL

Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple

Science.gov (United States)

Hu, Da-Gang; Zhang, Quan-Yan; An, Jian-Ping; You, Chun-Xiang; Hao, Yu-Jin

2016-01-01

Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF) MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants. PMID:27560976

Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple.

Directory of Open Access Journals (Sweden)

Da-Gang Hu

2016-08-01

Full Text Available Glucose induces anthocyanin accumulation in many plant species; however, the molecular mechanism involved in this process remains largely unknown. Here, we found that apple hexokinase MdHXK1, a glucose sensor, was involved in sensing exogenous glucose and regulating anthocyanin biosynthesis. In vitro and in vivo assays suggested that MdHXK1 interacted directly with and phosphorylated an anthocyanin-associated bHLH transcription factor (TF MdbHLH3 at its Ser361 site in response to glucose. Furthermore, both the hexokinase_2 domain and signal peptide are crucial for the MdHXK1-mediated phosphorylation of MdbHLH3. Moreover, phosphorylation modification stabilized MdbHLH3 protein and enhanced its transcription of the anthocyanin biosynthesis genes, thereby increasing anthocyanin biosynthesis. Finally, a series of transgenic analyses in apple calli and fruits demonstrated that MdHXK1 controlled glucose-induced anthocyanin accumulation at least partially, if not completely, via regulating MdbHLH3. Overall, our findings provide new insights into the mechanism of the glucose sensor HXK1 modulation of anthocyanin accumulation, which occur by directly regulating the anthocyanin-related bHLH TFs in response to a glucose signal in plants.

Novel 3D/VR interactive environment for MD simulations, visualization and analysis.

Science.gov (United States)

Doblack, Benjamin N; Allis, Tim; Dávila, Lilian P

2014-12-18

The increasing development of computing (hardware and software) in the last decades has impacted scientific research in many fields including materials science, biology, chemistry and physics among many others. A new computational system for the accurate and fast simulation and 3D/VR visualization of nanostructures is presented here, using the open-source molecular dynamics (MD) computer program LAMMPS. This alternative computational method uses modern graphics processors, NVIDIA CUDA technology and specialized scientific codes to overcome processing speed barriers common to traditional computing methods. In conjunction with a virtual reality system used to model materials, this enhancement allows the addition of accelerated MD simulation capability. The motivation is to provide a novel research environment which simultaneously allows visualization, simulation, modeling and analysis. The research goal is to investigate the structure and properties of inorganic nanostructures (e.g., silica glass nanosprings) under different conditions using this innovative computational system. The work presented outlines a description of the 3D/VR Visualization System and basic components, an overview of important considerations such as the physical environment, details on the setup and use of the novel system, a general procedure for the accelerated MD enhancement, technical information, and relevant remarks. The impact of this work is the creation of a unique computational system combining nanoscale materials simulation, visualization and interactivity in a virtual environment, which is both a research and teaching instrument at UC Merced.

75 FR 49956 - Dewey C. Mackay, M.D.; Revocation of Registration

Science.gov (United States)

2010-08-16

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-28] Dewey C. Mackay, M.D.; Revocation of Registration On February 26, 2009, I, the Deputy Administrator of the Drug Enforcement Administration (DEA), issued an Order to Show Cause and Immediate Suspension of Registration to Dewey C. MacKay...

Microsecond MD Simulations of Nano-patterned Polymer Brushes on Self-Assembled Monolayers

Science.gov (United States)

Buie, Creighton; Qiu, Liming; Cheng, Kwan; Park, Soyeun

2010-03-01

Nano-patterned polymer brushes end-grafted onto self-assembled monolayers have gained increasing research interests due to their unique thermodynamic properties and their chemical and biomedical applications in colloids, biosensing and tissue engineering. So far, the interactions between the polymer brushes with the surrounding environments such as the floor and solvent at the nanometer length scale and microsecond time scale are still difficult to obtained experimentally and computationally. Using a Coarse-Grained MD approach, polymer brushes of different monomeric lengths, grafting density and hydrophobicity of the monomers grafted on self-assembled monolayers and in explicit solvent were studied. Molecular level information, such as lateral diffusion, transverse height and volume contour of the brushes, were calculated from our microsecond-MD simulations. Our results demonstrated the significance of the hydration of the polymer in controlling the conformational arrangement of the polymer brushes.

MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

CERN Document Server

Fitterer, Miriam; Valishev, Alexander; Bruce, Roderik; Hofle, Wolfgang; Hostettler, Michi; Papadopoulou, Parthena Stefania; Papotti, Giulia; Papaphilippou, Yannis; Pellegrini, Dario; Trad, Georges; Valuch, Daniel; Valentino, Gianluca; Wagner, Joschka; Cai, Xu; CERN. Geneva. ATS Department

2018-01-01

For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015

77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

Science.gov (United States)

2012-11-15

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-51] Karen Paul Holley, M.D... revoke the DEA Certificate of Registration (COR), Number BH8988339, of Karen Paul Holley, M.D....D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez...

Campus dialogue

African Journals Online (AJOL)

Over the past two decades, the South African higher education community has introduced many diverse and innovative programmes to improve the first-year experience (FYE) for students, such as orientation, peer learning, supplemental instruction, academic support services, and different curriculum initiatives. However ...

Failure to launch: the self-regulating Md-MYB10 R6 gene from apple is active in flowers but not leaves of Petunia.

Science.gov (United States)

Boase, Murray R; Brendolise, Cyril; Wang, Lei; Ngo, Hahn; Espley, Richard V; Hellens, Roger P; Schwinn, Kathy E; Davies, Kevin M; Albert, Nick W

2015-10-01

The Md - MYB10 R6 gene from apple is capable of self-regulating in heterologous host species and enhancing anthocyanin pigmentation, but the activity of MYB10 is dependent on endogenous protein partners. Coloured foliage due to anthocyanin pigments (bronze/red/black) is an attractive trait that is often lacking in many bedding, ornamental and horticultural plants. Apples (Malus × domestica) containing an allelic variant of the anthocyanin regulator, Md-MYB10 R6 , are highly pigmented throughout the plant, due to autoregulation by MYB10 upon its own promoter. We investigated whether Md-MYB10 R6 from apple is capable of functioning within the heterologous host Petunia hybrida to generate plants with novel pigmentation patterns. The Md-MYB10 R6 transgene (MYB10-R6 pro :MYB10:MYB10 term ) activated anthocyanin synthesis when transiently expressed in Antirrhinum rosea (dorsea) petals and petunia leaf discs. Stable transgenic petunias containing Md-MYB10 R6 lacked foliar pigmentation but had coloured flowers, complementing the an2 phenotype of 'Mitchell' petunia. The absence of foliar pigmentation was due to the failure of the Md-MYB10 R6 gene to self-activate in vegetative tissues, suggesting that additional protein partners are required for Md-MYB10 to activate target genes in this heterologous system. In petunia flowers, where endogenous components including MYB-bHLH-WDR (MBW) proteins were present, expression of the Md-MYB10 R6 promoter was initiated, allowing auto-regulation to occur and activating anthocyanin production. Md-MYB10 is capable of operating within the petunia MBW gene regulation network that controls the expression of the anthocyanin biosynthesis genes, AN1 (bHLH) and MYBx (R3-MYB repressor) in petals.

“Wer jetzt kein Haus hat, baut sich keines mehr”. Notes on Bruce O’Neill’s "The Space of Boredom"

Directory of Open Access Journals (Sweden)

George Tudorie

2017-12-01

Full Text Available Bruce O’Neill describes homeless men and women in Bucharest who could not navigate the downward spiral which followed the meltdown of the state-run economy after 1989. Deprived of the culturally treasured anchors of work, home, and family, and unable to participate in anything recognizably meaningful, these individuals are forced into a position of malignant contemplation, even when busy surviving. It is an experience of paralyzed restlessness which resonates with the ruins they zigzag through. The Space of Boredom captures this landscape convincingly, and in elegant prose. The book moves effortlessly from the discussion of scholarly works in a number of fields, to observation of sometimes cinematic quality. It is well argued, abundantly researched, and clear about its theoretical assumptions. If some questions remain to be answered, at least to this reader, this may be an artifact of background. Assumptions, including important ones about the nature of affects, and about boredom itself, may not be shared. Some questions of this kind will be raised in the following.

Harold E. Varmus, MD.

Science.gov (United States)

Varmus, H E

1995-06-01

On November 19, 1993, the Senate approved the nomination of Harold E. Varmus, MD, as Director of the National Institutes of Health (NIH). Varmus, who received the 1989 Nobel Prize in Medicine, brought unquestioned credentials as a scientist to the NIH. Despite his limited background as an administrator, Varmus has received high marks from most observers for improving the morale of NIH staffers and implementing streamlined procedures in the grant review process. His tenure has not been free of controversy, however. Many clinical researchers have long felt there is a bias in NIH study sections against patient-oriented research. A recent study sponsored by the Division of Research Grants confirmed the lower success rate of patient-oriented research proposals, but the outcome of these findings remains unclear. Faced with mounting political pressure for a balanced budget, and the resultant reduction of funding to many branches of government, Varmus has been a strong voice for non-targeted investigator initiated research. Interviewed in his office in Building One on the NIH campus in Bethesda, Maryland, Varmus discussed the state of patient oriented research, the evolving role of the NIH in supporting science, and just where the money to pay for it should be found.

Infrared microspectroscopy of live cells in microfluidic devices (MD-IRMS): toward a powerful label-free cell-based assay.

Science.gov (United States)

Vaccari, L; Birarda, G; Businaro, L; Pacor, S; Grenci, G

2012-06-05

Until nowadays most infrared microspectroscopy (IRMS) experiments on biological specimens (i.e., tissues or cells) have been routinely carried out on fixed or dried samples in order to circumvent water absorption problems. In this paper, we demonstrate the possibility to widen the range of in-vitro IRMS experiments to vibrational analysis of live cellular samples, thanks to the development of novel biocompatible IR-visible transparent microfluidic devices (MD). In order to highlight the biological relevance of IRMS in MD (MD-IRMS), we performed a systematic exploration of the biochemical alterations induced by different fixation protocols, ethanol 70% and formaldehyde solution 4%, as well as air-drying on U937 leukemic monocytes by comparing their IR vibrational features with the live U937 counterpart. Both fixation and air-drying procedures affected lipid composition and order as well as protein structure at a different extent while they both induced structural alterations in nucleic acids. Therefore, only IRMS of live cells can provide reliable information on both DNA and RNA structure and on their cellular dynamic. In summary, we show that MD-IRMS of live cells is feasible, reliable, and biologically relevant to be recognized as a label-free cell-based assay.

76 FR 47231 - Redelegation of Authority to the Deputy Assistant Secretaries for Public and Indian Housing

Science.gov (United States)

2011-08-04

... delegate functions, powers, and duties as the Secretary deems necessary. By separate notice published in... Estate Assessment Center; 2. Required conversions pursuant to section 33, voluntary conversions pursuant... to change their fiscal year end (FYE) subject to coordination with the Real Estate Assessment Center...

Designing and conducting MD/MPH dual degree program in the Medical School of Shiraz University of Medical Sciences.

Science.gov (United States)

Salehi, Alireza; Hashemi, Neda; Saber, Mahboobeh; Imanieh, Mohammad Hadi

2015-07-01

Many studies have focused on the need of health systems to educated physicians in the clinical prevention, research methodology, epidemiology and health care management and emphasize the important role of this training in the public health promotion. On this basis, Shiraz University of Medical Sciences (SUMS) has established MD/MPH dual degree program since the year 2012. In the current study, Delphi technique was used. Both qualitative and quantitative methods were applied in the Delphi process. The Delphi team members including experts with extensive experience in teaching, research and administration in the field of educational management and health/medical education reached consensus in almost 86% of the questionnaire items through three Delphi rounds. MD/MPH program for SUMS was designed based on the items agreed and thematic analysis used in these rounds. The goals, values, mission and program requirements including the period, the entrance condition, and the number of units, and certification were determined. Accordingly, the courses of the program are presented in parallel with the MD education period. MPH courses consist of 35 units including 16 obligatory and 15 voluntary ones. Designing MD/MPH program in SUMS based on the existent models in the universities in different countries, compatible with educational program of this university and needs of national health system in Iran, can be a beneficial measure towards promoting the students' knowledge and theoretical/practical skills in both individual and social level. Performing some additional research to assess the MD/MPH program and some cohort studies to evaluate the effect of this program on the students' future professional life is recommended.

Property values, parks, and crime: a hedonic analysis in Baltimore, MD

Science.gov (United States)

Austin Troy; J. Morgan Grove

2008-01-01

While urban parks are generally considered to be a positive amenity, past research suggests that some parks are perceived as a neighborhood liability. Using hedonic analysis of property data in Baltimore, MD, we attempted to determine whether crime rate mediates how parks are valued by the housing market. Transacted price was regressed against park proximity, area-...

77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

Science.gov (United States)

2012-06-12

..., M.D. (Respondent), of Morehead City, N.C. The Order proposed the revocation of Respondent's DEA... pleading entitled: ``Notice To The Administrator Regarding State Authority,'' with attachments. Therein..., at 3. This Order was effective on December 8, 2011. Id., Attachment 5, at 6. Upon review of the...

75 FR 53574 - Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD

Science.gov (United States)

2010-09-01

...-AA00 Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during five fireworks displays launched from a discharge barge located... necessary to protect persons and vessels against the hazards associated with a fireworks display on...

Expression Analysis of the MdCIbHLH1 Gene in Apple Flower Buds and Seeds in the Process of Dormancy

Directory of Open Access Journals (Sweden)

Yiran Ren

2016-03-01

Full Text Available A bHLH transcription factor that is induced by low temperature was found in apple (Malus × domestica Borkh.. To understand the sequence characteristics of the gene, bioinformatics analysis was performed. Furthermore, gene expression patterns of the laminated apple seeds and lateral flower buds were analyzed during the period of dormancy release with semi-quantitative RT-PCR. Based on secondary structure predictions, the results showed that the MdCIbHLH1 protein structure mainly included α-helix and random coil, while β-sheet and extended strand content was less. Semi-quantitative RT-PCR analysis showed that the expression patterns of MdCIbHLH1 were similar in laminated apple seeds and lateral flower buds during the period of dormancy release. Before dormancy release, expression levels of MdCIbHLH1 were high and gradually decreased during the period of dormancy release. These results indicated that MdCIbHLH1 might play an important role during dormancy release in apple seeds and apple buds.

Proteomics and SSH analyses of ALA-promoted fruit coloration and evidence for the involvement of a MADS-box gene, MdMADS1

Directory of Open Access Journals (Sweden)

Xinxin Feng

2016-11-01

Full Text Available Skin color is a key quality attribute of fruits and how to improve fruit coloration has long been a major concern. 5-Aminolevulinic acid (ALA, a natural plant growth regulator, can significantly increase anthocyanin accumulation in fruit skin and therefore effectively improve coloration of many fruits, including apple. However, the molecular mechanism how ALA stimulates anthocyanin accumulation in fruit skin remains unknown. Here, we investigated the impact of ALA on apple skin at the protein and mRNA levels. A total of 85 differentially expressed proteins in apple skins between ALA and water treatment (control were identified by complementary gel-based and gel-freeseparation techniques. Most of these differentially expressed proteins were up-regulated by ALA. Function analysis suggested that 87.06% of the ALA-responsive proteins were associated with fruit ripening. To further screen ALA-responsive regulators, we constructed a subtracted cDNA library (tester: ALA treatment; driver: control and obtained 104 differentially expressed unigenes, of which 38 unigenes were indicators for the fruit ripening-related gene. The differentially changed proteins and transcripts did not correspond well at an individual level, but showed similar regulated direction in function at the pathway level. Among the identified fruit ripening-related genes, the expression of MdMADS1, a developmental transcription regulator of fruit ripening, was positively correlated with expression of anthocyanin biosynthetic genes (MdCHS, MdDFR, MdLDOX and MdUFGT in apple skin under ALA treatment. Moreover, overexpression of MdMADS1 enhanced anthocyanin content in transformed apple calli, which was further enhanced by ALA. The anthocyanin content in MdMADS1-silenced calli was less than that in the control with ALA treatment, but higher than that without ALA treatment. These results indicated that MdMADS1 is involved in ALA-induced anthocyanin accumulation. In addition, anthocyanin

The first nationwide survey of MD-PhDs in the social sciences and humanities: training patterns and career choices.

Science.gov (United States)

Holmes, Seth M; Karlin, Jennifer; Stonington, Scott D; Gottheil, Diane L

2017-03-21

While several articles on MD-PhD trainees in the basic sciences have been published in the past several years, very little research exists on physician-investigators in the social sciences and humanities. However, the numbers of MD-PhDs training in these fields and the number of programs offering training in these fields are increasing, particularly within the US. In addition, accountability for the public funding for MD-PhD programs requires knowledge about this growing population of trainees and their career trajectories. The aim of this paper is to describe the first cohorts of MD-PhDs in the social sciences and humanities, to characterize their training and career paths, and to better understand their experiences of training and subsequent research and practice. This paper utilizes a multi-pronged recruitment method and novel survey instrument to examine an understudied population of MD-PhD trainees in the social sciences and humanities, many of whom completed both degrees without formal programmatic support. The survey instrument was designed to collect demographic, training and career trajectory data, as well as experiences of and perspectives on training and career. It describes their routes to professional development, characterizes obstacles to and predictors of success, and explores career trends. The average length of time to complete both degrees was 9 years. The vast majority (90%) completed a clinical residency, almost all (98%) were engaged in research, the vast majority (88%) were employed in academic institutions, and several others (9%) held leadership positions in national and international health organizations. Very few (4%) went into private practice. The survey responses supply recommendations for supporting current trainees as well as areas for future research. In general, MD-PhDs in the social sciences and humanities have careers that fit the goals of agencies providing public funding for training physician-investigators: they are involved

Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

International Nuclear Information System (INIS)

Leopold, Kenneth A.; Ahles, Tim A.; Walch, Susan; Amdur, Robert J.; Mott, Leila A.; Wiegand-Packard, Linda; Oxman, Thomas E.

1998-01-01

Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

David Schimmelpenninck van der Oye and Bruce W. Menning, eds., Reforming the Tsar's Army: Military Innovation in Imperial Russia from Peter the Great to the Revolution, Washington, DC: Woodrow Wilson Center and Cambridge: Cambridge UP, 2004.

Directory of Open Access Journals (Sweden)

David Stone

2006-11-01

Full Text Available David Schimmelpenninck and Bruce Menning have produced an excellent volume collecting contributions of a number of both well-established and junior scholars on the history and development of the tsarist military, grouped together around the general theme of reform. In some ways, it is comparable to Eric Lohr and Marshall Poe's complementary The Military and Society in Russia, 1450-1917 (Leiden, 2002. Schimmelpenninck and Menning's contributors, however, focus more on political and institutio...

Application of the perturbation series expansion quantum Monte Carlo method to multiorbital systems having Hund's coupling

International Nuclear Information System (INIS)

Sakai, Shiro; Arita, Ryotaro; Aoki, Hideo

2006-01-01

We propose a new quantum Monte Carlo method especially intended to couple with the dynamical mean-field theory. The algorithm is not only much more efficient than the conventional Hirsch-Fye algorithm, but is applicable to multiorbital systems having an SU(2)-symmetric Hund's coupling as well

Improved synthesis of (3E,6Z,9Z)-1,3,6,9-nonadecatetraene, attraction inhibitor of bruce spanworm, Operophtera bruceata, to pheromone traps for monitoring winter moth, Operophtera brumata.

Science.gov (United States)

Khrimian, Ashot; Lance, David R; Mastro, Victor C; Elkinton, Joseph S

2010-02-10

The winter moth, Operophtera brumata (Lepidoptera: Geometridae), is an early-season defoliator that attacks a wide variety of hardwoods and, in some cases, conifers. The insect is native to Europe but has become established in at least three areas of North America including southeastern New England. The female-produced sex attractant pheromone of the winter moth was identified as (3Z,6Z,9Z)-1,3,6,9-nonadecatetraene (1), which also attracts a native congener, the Bruce spanworm, Operophtera bruceata . Dissection, or (for certainty) DNA molecular testing, is required to differentiate between males of the two species. Thus, a trapping method that is selective for winter moth would be desirable. A geometric isomer of the pheromone, (3E,6Z,9Z)-1,3,6,9-nonadecatetraene (2), can reportedly inhibit attraction of Bruce spanworm to traps without affecting winter moth catch, but use of the pheromone and inhibitor together has not been optimized, nor has the synthesis of the inhibitor. This paper presents two new syntheses of the inhibitor (3E,6Z,9Z)-1,3,6,9-nonadecatetraene based on the intermediate (3Z,6Z)-3,6-hexadecadien-1-ol (4), which has also been utilized in the synthesis of the pheromone. The syntheses combine traditional acetylenic chemistry and Wittig olefination reactions. In one approach, 2 was synthesized in 80% purity (20% being pheromone 1), and in the second, tetraene 2 of 96% purity (and free of 1) was produced in 25% overall yield from dienol 4. The last method benefitted from a refined TEMPO-mediated PhI(OAc)(2) oxidation of 4 and a two-carbon homologation of the corresponding aldehyde 7.

Curriculum scholars: Embedding learning and teaching scholarship in first year academic identities. A Practice Report

Directory of Open Access Journals (Sweden)

Peter Jones

2011-07-01

Full Text Available This practice report details an institutional innovation designed to enhance academic capacities for curriculum development, with a particular focus on the first year experience (FYE. The authors discuss the appointment of “Curriculum Scholars” in each of the faculties at James Cook University. This innovation can be seen as an example of third generation responses to the challenges of the first year in higher education (FYHE (Kift, Nelson & Clarke, 2010. The report  discusses the question of academic identity and the tension between a discipline-specific identity and identification with the scholarship of teaching and learning. The authors argue that this tension may have significant implications for the success of third generation approaches to the FYE. This tension is the focus of a multi-method research project being developed by the authors. The autoethnographical dimension of this project is described, inviting participants to reflect on their own journeys as academics engaged in learning and teaching.

Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

Optimizing the use of operating experience at Ontario Hydro's Bruce Nuclear Generating Station 'A'

Energy Technology Data Exchange (ETDEWEB)

Williams, E L [Operating Experience Reactor Safety, Bruce Nuclear Generating Station ' A' , Ontario Hydro, Tiverton, Ontario (Canada)

1991-04-01

One of the most significant lessons learned from the Three Mile Island event (March 1979), and again with the Chernobyl disaster - (April 1986) was the ongoing requirement to learn from our mistakes and near misses, and those of our fellow utilities around the world: so that as an industry we do not repeat the same mistakes. The very future of our industry will depend on how well each one of us accomplishes this important ask. This paper describes in detail the challenges encountered by one station when incorporating a comprehensive 'Operating Program'. It begins with the Corporate Office's directives to its stations for such a program; and follows up with the details of the actual station implementation of the program, and day to day operating experiences. The paper describes in detail the following Operating Experience programs: - Root Cause Determination process. The Institute of Nuclear Power Operations, Human Performance Enhancement System (HPES) as an integral component of the Root Cause process. Finding solutions for our station for problems identified elsewhere is covered herein; - Significant Event Recommendation Tracking System: - Commitment Tracking System; - Operating Experience (Sharing Lessons Learned) System. The paper will show all the above processes tie closely together and complement each other. The paper discusses the staff required for such processes and their training requirements. It recommends process time lines, reporting mechanisms, and sign off requirements. It will describe the equipment utilized to carry out this work effectively, and with a minimum of staff. One unique feature of the Bruce 'A' system is an 'Effectiveness Follow-Up', usually three to six months after the event recommendations have been completed. By rechecking the finished actions and reviewing them with the personnel involved with the originating event we ensure that the real root causes have been identified and resolved. (author)

Optimizing the use of operating experience at Ontario Hydro's Bruce Nuclear Generating Station 'A'

International Nuclear Information System (INIS)

Williams, E.L.

1991-01-01

One of the most significant lessons learned from the Three Mile Island event (March 1979), and again with the Chernobyl disaster - (April 1986) was the ongoing requirement to learn from our mistakes and near misses, and those of our fellow utilities around the world: so that as an industry we do not repeat the same mistakes. The very future of our industry will depend on how well each one of us accomplishes this important ask. This paper describes in detail the challenges encountered by one station when incorporating a comprehensive 'Operating Program'. It begins with the Corporate Office's directives to its stations for such a program; and follows up with the details of the actual station implementation of the program, and day to day operating experiences. The paper describes in detail the following Operating Experience programs: - Root Cause Determination process. The Institute of Nuclear Power Operations, Human Performance Enhancement System (HPES) as an integral component of the Root Cause process. Finding solutions for our station for problems identified elsewhere is covered herein; - Significant Event Recommendation Tracking System: - Commitment Tracking System; - Operating Experience (Sharing Lessons Learned) System. The paper will show all the above processes tie closely together and complement each other. The paper discusses the staff required for such processes and their training requirements. It recommends process time lines, reporting mechanisms, and sign off requirements. It will describe the equipment utilized to carry out this work effectively, and with a minimum of staff. One unique feature of the Bruce 'A' system is an 'Effectiveness Follow-Up', usually three to six months after the event recommendations have been completed. By rechecking the finished actions and reviewing them with the personnel involved with the originating event we ensure that the real root causes have been identified and resolved. (author)

Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

Science.gov (United States)

O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

2015-02-01

The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce.

78 FR 68002 - Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD

Science.gov (United States)

2013-11-13

... 1625-AA00 Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during a fireworks display launched from a barge located in Baltimore... rule involves a fireworks display associated with a New Year's Eve event that will take place in...

MD-11 PCA - Research flight team egress

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 has parked on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. Coming down the steps from the aircraft are Gordon Fullerton (in front), followed by Bill Burcham, Propulsion Controlled Aircraft (PCA) project engineer at Dryden; NASA Dryden controls engineer John Burken; John Feather of McDonnell Douglas; and Drew Pappas, McDonnell Douglas' project manager for PCA.

β∗ levelling using the LHC Lumi Server (MD 2427)

CERN Document Server

Hostettler, Michi; Fuchsberger, Kajetan; Gabriel, Mathieu; Hemelsoet, Georges-Henry; Hruska, Marek; Jacquet, Delphine; Wenninger, Jorg; CERN. Geneva. ATS Department

2018-01-01

Luminosity levelling by β∗ is the baseline scenario for HL-LHC and will possibly be used in 2018 LHC operation. In this MD, we commissioned a novel controls approach to β∗ levelling using improved LSA trims and automatic orchestration. Compared to the regular squeeze using sequences, this approach is aimed to be minimally invasive to LHC operation in Stable Beams. Using this tool, we demonstrated the feasibility of β∗ levelling between 1 m and 30 cm.

MD 1691: Active halo control using tune ripple at injection

CERN Document Server

Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

2017-01-01

In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

75 FR 31511 - Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-06-03

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-46: OTS No. 08283] Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on May 24, 2010, the Office of Thrift Supervision approved the application of Ideal Federal Savings Bank...

75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

Science.gov (United States)

2010-04-09

... the event, and enhancing public and maritime safety. Basis and Purpose Fireworks displays are... promote public and maritime safety during a fireworks display, and to protect mariners transiting the area...-AA00 Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD AGENCY: Coast Guard...

77 FR 11434 - Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD

Science.gov (United States)

2012-02-27

...-AA00 Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD AGENCY: Coast Guard, DHS... intended route immediately prior to, during, and following the scheduled towing evolution, vessel traffic... made to the maritime community via marine information broadcasts so mariners may adjust their plans...

Report from LHC MD 2158: IR-nonlinear studies

CERN Document Server

Maclean, Ewen Hamish; Cruz Alaniz, Emilia; Dalena, Barbara; Dilly, Joschua Werner; Fol, Elena; Giovannozzi, Massimo; Hofer, Michael; Malina, Lukas; Persson, Tobias Hakan Bjorn; Coello De Portugal - Martinez Vazquez, Jaime Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Garcia-Tabares Valdivieso, Ana; Wegscheider, Andreas; CERN. Geneva. ATS Department

2018-01-01

For the first time the LHC is running for luminosity-production with local corrections for nonlinear errors in the ATLAS and CMS insertions. While a major step forward in LHC optics commissioning strategy (and one which has yielded clear operational benefits) considerable challenges remain to be overcome, both in regard to the optimization of LHC optics and in order to ensure successful commissioning of the High-Luminosity LHC. MD 2158 sought to follow up several aspects of the 2017 nonlinear optics commissioning which are not yet understood, and by enhancing sextupole and dodecapole sources in the ATLAS and CMS insertions explore the prospects for linear and nonlinear optics commissioning in the HL-LHC.

Virtual synthesis of crystals using ab initio MD: Case study on LiFePO4

Science.gov (United States)

Mishra, S. B.; Nanda, B. R. K.

2017-05-01

Molecular dynamics simulation technique is fairly successful in studying the structural aspects and dynamics of fluids. Here we study the ability of ab initio molecular dynamics (ab initio MD) to carry out virtual experiments to synthesize new crystalline materials and to predict their structures. For this purpose the olivine phosphate LiFePO4 (LFPO) is used as an example. As transition metal oxides in general are stabilized with layered geometry, we carried out ab initio MD simulations over a hypothetical layered configuration consisting of alternate LiPO2 and FeO2 layers. With intermittent steps of electron minimization, the resulted equilibrium lattice consist of PO4 tetrahedra and distorted Fe-O complexes similar to the one observed in the experimental lattice.

Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

NARCIS (Netherlands)

Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

77 FR 42179 - Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD

Science.gov (United States)

2012-07-18

...]30[sec] W, located at Newburg in Charles County, Maryland (NAD 1983). The temporary safety zone will... 1625-AA00 Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard will establish a safety zone upon...

Examining Summer Laboratory Research Apprenticeships for High School Students as a Factor in Entry to MD/PhD Programs at Matriculation

Science.gov (United States)

Tai, Robert H.; Kong, Xiaoqing; Mitchell, Claire E.; Dabney, Katherine P.; Read, Daniel M.; Jeffe, Donna B.; Andriole, Dorothy A.; Wathington, Heather D.

2017-01-01

Do summer laboratory research apprenticeships during high school have an impact on entry into MD/PhD programs? Apart from the nearly decade-long span of time between high school and matriculation into an MD/PhD program, young people have many life-shaping experiences that presumably impact their education and career trajectories. This quantitative…

78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

Science.gov (United States)

2013-05-31

... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... Atlantic Ocean in Ocean City, MD. In recent years, there have been unfortunate instances of jets and planes...

75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

Science.gov (United States)

2010-08-24

...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

MD 979: Beta-beating measurements on colliding beams

CERN Document Server

Goncalves Jorge, Patrik; Pieloni, Tatiana; Buffat, Xavier; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fol, Elena; Langner, Andy Sven; Medina Medrano, Luis Eduardo; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wegscheider, Andreas; CERN. Geneva. ATS Department

2017-01-01

The HL-LHC high brightness beams will give a large β-beating due to the head-on and long-range interactions since a beam-beam parameter of 0.01 per Interaction Point (IP) is expected. The β-heating induced by two head-on collision reaches 15%. A third IP, i.e. IP8, could bring the β-heating up to 24%. The aim of the Machine Development (MD) study was to test optics measurements with AC dipole and ADT on colliding beams at injection and to implement a correction of the β-heating due to to head-on collision in the two experiments IP1&5. Int his note, we summarize the first results of this test performed in the LHC.

Creating an Engaging Library Orientation: First Year Experience Courses at UC San Diego

Science.gov (United States)

Goldman, Crystal; Turnbow, Dominique; Roth, Amanda; Friedman, Lia; Heskett, Karen

2016-01-01

This article focuses on the development of an engaging library orientation module for UC San Diego First Year Experience (FYE) courses. The library module included a brief in-class presentation about research concepts and library services, an online interactive library scavenger hunt given as an in-class activity, and a homework assignment where…

Social Adjustment of College Freshmen: The Importance of Gender and Living Environment

Science.gov (United States)

Enochs, Wendy K.; Roland, Catherine B.

2006-01-01

The relationship between living environment, gender and both overall adjustment to college and social adjustment in freshmen students was examined in this study. The College Adjustment Scales were administered to 511 freshmen students living in on-campus housing. There were 259 students living in Freshmen Year Experience (FYE) Halls verses 252…

A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

Science.gov (United States)

Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

2015-04-01

Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

Science.gov (United States)

Topper, James N; Rutherford, John D

2016-11-15

Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis.

Science.gov (United States)

Peyro Saint Paul, Laure; Debruyne, Danièle; Bernard, Delphine; Mock, Donald M; Defer, Gilles L

2016-01-01

Multiple sclerosis (MS) is a chronic, potentially highly disabling neurological disorder. No disease-modifying treatments are approved in the progressive and not active forms of the disease. High doses of biotin were tested in an open-label pilot study involving 23 patients with progressive MS and reported positive results. A randomized, double-blind, placebo-controlled trial in 154 progressive MS patients confirmed the beneficial effect of MD1003 (high-dose biotin) on reversing or stabilizing disability progression, with a good safety profile. It is proposed that MD1003 in progressive MS 1) increases energy production in demyelinated axons and/or 2) enhances myelin synthesis in oligodendrocytes. Biotin is highly bioavailable; absorption and excretion are rapid. The major route of elimination is urinary excretion. A high oral dose of biotin seems generally well tolerated but a few important safety concerns were identified: 1) teratogenicity in one species and 2) interference with some biotin-based laboratory immunoassays. The animal toxicity data are limited at such high doses. Further preclinical studies would be useful to address the mechanism of action of MD1003. Assessment of clinical benefit duration in responders will be also very important to set. Results of randomized, placebo-controlled trial are reassuring and provide hope for the treatment of progressive MS.

Property Analysis of Exfoliated Graphite Nanoplatelets Modified Asphalt Model Using Molecular Dynamics (MD Method

Directory of Open Access Journals (Sweden)

Hui Yao

2017-01-01

Full Text Available This Molecular Dynamics (MD simulation paper presents a physical property comparison study between exfoliated graphite nanoplatelets (xGNP modified and control asphalt models, including density, glass transition temperature, viscosity and thermal conductivity. The three-component control asphalt model consists of asphaltenes, aromatics, and saturates based on previous references. The xGNP asphalt model was built by incorporating an xGNP and control asphalt model and controlling mass ratios to represent the laboratory prepared samples. The Amber Cornell Extension Force Field (ACEFF was used with assigned molecular electro-static potential (ESP charge from NWChem analysis. After optimization and ensemble relaxation, the properties of the control and xGNP modified asphalt models were computed and analyzed using the MD method. The MD simulated results have a similar trend as the test results. The property analysis showed that: (1 the density of the xGNP modified model is higher than that of the control model; (2 the glass transition temperature of the xGNP modified model is closer to the laboratory data of the Strategic Highway Research Program (SHRP asphalt binders than that of the control model; (3 the viscosities of the xGNP modified model at different temperatures are higher than those of the control model, and it coincides with the trend in the laboratory data; (4 the thermal conductivities of the xGNP modified asphalt model are higher than those of the control asphalt model at different temperatures, and it is consistent with the trend in the laboratory data.

Radioprotective and radiotherapeutic properties of biotechnological agent MD2

International Nuclear Information System (INIS)

Sobol, C.V.; Komar, V.E.; Sobol, Y.T.

1996-01-01

In recent years as the result of nuclear testing and accidents at nuclear power plants such as Chernobyl, etc. radiation exposure has become a major issue in various parts of the world. Experience of recent nuclear accidents has shown there is no effective treatment for patients expose to doses of radiation that result in fatal hematopoietic failure and /or secondary infections. Therefore, agents that are effective when administered after irradiation, are of great interest. In this study, the possibility of using biotechnological agent MD2 after lethal total body irradiation (TBI) and radiotherapy has been demonstrated. In addition, the considerable radioprotection without toxic effect can be obtained. (author)

A molecular dynamics (MD simulation on tire-aggregate friction

Directory of Open Access Journals (Sweden)

Fengyan Sun

2017-07-01

Full Text Available The friction between tire and road surface is fundamentally depending on the molecular forces. In this paper, the nanoscale 3D contact model is employed to investigate the tire-aggregate friction mechanism. The tire and aggregate micro-structure are both constructed to evaluate the microscopic performance of tire-aggregate friction influence. Simulation results show for a high velocity, the energy dissipation of sliding on crystal structure is small, which results in a small friction coefficient; temperature will have influences on the friction coefficient, and with the increasing of velocity, the effect will gradually reduce. Keywords: Tire, Aggregate, Friction coefficient, Microscopic mechanism, MD simulation

76 FR 9407 - Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2011-02-17

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-58 OTS No. 01292 and H 4762] Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on February 10, 2011, the Office of Thrift Supervision approved the application of...

76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

Science.gov (United States)

2011-04-11

... pre-packaged food and beverage. This action is necessary to avoid interruption of visitor services... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-CONC-0111-6544; 2410-OYC] Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service...

Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR.

Science.gov (United States)

Westermaier, Yvonne; Ruiz-Carmona, Sergio; Theret, Isabelle; Perron-Sierra, Françoise; Poissonnet, Guillaume; Dacquet, Catherine; Boutin, Jean A; Ducrot, Pierre; Barril, Xavier

2017-08-01

The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a molecular dynamics (MD)-based approach can be used to predict the free energy of small molecules, and to provide priorities for the synthesis and the validation via in vitro tests. Here, we study the dynamics and energetics of the nuclear receptor REV-ERBα with its co-repressor NCoR and 35 novel agonists. Our in silico approach combines molecular docking, molecular dynamics (MD), solvent-accessible surface area (SASA) and molecular mechanics poisson boltzmann surface area (MMPBSA) calculations. While docking yielded initial hints on the binding modes, their stability was assessed by MD. The SASA calculations revealed that the presence of the ligand led to a higher exposure of hydrophobic REV-ERB residues for NCoR recruitment. MMPBSA was very successful in ranking ligands by potency in a retrospective and prospective manner. Particularly, the prospective MMPBSA ranking-based validations for four compounds, three predicted to be active and one weakly active, were confirmed experimentally.

MD 2408: Study of Schottky Monitors for Q' Measurement at Injection

CERN Document Server

Tydecks, Tobias; Levens, Tom; Wendt, Manfred; Wenninger, Jorg; CERN. Geneva. ATS Department

2018-01-01

The Schottky monitors installed at the LHC enable the detection of Schottky noise of the two circulating proton / ion beams. From Schottky noise, beam parameters like tune, chromaticity, and relative emittance, can be extracted in a non-destructive and purely parasitic method of measurement. The primary goal of this MD was to study the Schottky monitors capability to reliably and accurately determine the beam chromaticities at injection energy. Furthermore, the possibility to track the beam emittance has been investigated.

Influence of Code Size Variation on the Performance of 2D Hybrid ZCC/MD in OCDMA System

Directory of Open Access Journals (Sweden)

Matem Rima.

2018-01-01

Full Text Available Several two dimensional OCDMA have been developed in order to overcome many problems in optical network, enhancing cardinality, suppress Multiple Access Interference (MAI and mitigate Phase Induced Intensity Noise (PIIN. This paper propose a new 2D hybrid ZCC/MD code combining between 1D ZCC spectral encoding where M is its code length and 1D MD spatial spreading where N is its code length. The spatial spreading (N code length offers a good cardinality so it represents the main effect to enhance the performance of the system compared to the spectral (M code length according to the numerical results.

78 FR 56912 - Notice of Regulatory Waiver Requests Granted for the Second Quarter of Calendar Year 2013

Science.gov (United States)

2013-09-16

... fraud and misuse of city funds, which resulted in a forensic audit investigation, the audited financial...) fiscal year end (FYE), in accordance with the Single Audit Act and OMB Circular A-133. Granted By: Sandra... Waived: The VHA requested a waiver of the audit due date as a result of the State of California...

Leonard F. Peltier, MD, PhD, 1920-2003.

Science.gov (United States)

Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

2004-05-01

Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

75 FR 51333 - Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

Science.gov (United States)

2010-08-19

... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-49: OTS Nos. 08156 and H4736] Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on August 12, 2010, the Office of Thrift Supervision approved the application of Madison Square...

75 FR 50878 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-08-18

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... McDonnell Douglas Corporation: Amendment 39-16388. Docket No. FAA-2010-0433; Directorate Identifier 2009-NM..., 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas Corporation Model...

75 FR 68245 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-11-05

...-1043; Directorate Identifier 2010-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... McDonnell Douglas Model MD-90-30 airplanes. This proposed AD would require installing new fire handle... airworthiness directive (AD): McDonnell Douglas Corporation: Docket No. FAA-2010-1043; Directorate Identifier...

75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-12-23

...-1202; Directorate Identifier 2010-NM-167-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model MD-90-30 airplanes, certificated in any category. Subject (d) Joint Aircraft...

The University of Toronto's lasting contribution to war surgery: how Maj. L. Bruce Robertson fundamentally transformed thinking toward blood transfusion during the First World War.

Science.gov (United States)

Tien, Abigail; Beckett, Andrew; Pannell, Dylan

2017-06-01

During the Great War, Canadian military surgeons produced some of the greatest innovations to improve survival on the battlefield. Arguably, the most important was bringing blood transfusion practice close to the edge of the battlefield to resuscitate the many casualties dying of hemorrhagic shock. Dr. L. Bruce Robertson of the Canadian Army Medical Corps was the pioneering surgeon from the University of Toronto who was able to demonstrate the benefit of blood transfusions near the front line and counter the belief that saline was the resuscitation fluid of choice in military medicine. Robertson would go on to survive the Great War, but would be taken early in life by influenza. Despite his life and career being cut short, Robertson's work is still carried on today by many military medical organizations who strive to bring blood to the wounded in austere and dangerous settings. This article has an Appendix, available at canjsurg.ca.

MD-11 PCA - First Landing at Edwards

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 approaches the first landing ever of a transport aircraft under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when it normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-04-26

...-0433; Directorate Identifier 2009-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... main landing gear (MLG) during gear extension, damaging the hydraulic system on McDonnell Douglas.... The retract cylinder support fittings for the MLG on McDonnell Douglas Model MD-80 series airplanes...

75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-06-28

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... Douglas Corporation: Docket No. FAA-2010-0554; Directorate Identifier 2010-NM-082-AD. Comments Due Date (a... supersedes AD 2009-07-04, Amendment 39-15863. Applicability (c) This AD applies to McDonnell Douglas...

Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

Science.gov (United States)

Dhindsa, Gurpreet K.

Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

Non-linear beam dynamics tests in the LHC: LHC dynamic aperture MD on Beam 2 (24th of June 2012)

CERN Document Server

Maclean, E H; Persson, T H B; Redaelli, S; Schmidt, F; Tomas, R; Uythoven, J

2013-01-01

This MD note summarizes measurements performed on LHC Beam 2 during the non-linear machine development (MD) of 24 June 2012. The aim of the measurement was to observe the dynamic aperture of LHC Beam 2, and obtain turn-by-turn (TbT) betatron oscillation data, enabling the study of amplitude detuning and resonance driving terms (RDTs). The regular injections required by the MD also represented an opportunity to test a new coupling feedback routine based on the analysis of injection oscillation data. Initial measurements were performed on the nominal state of the LHC at injection. On completion of this study the Landau octupoles were turned off and corrections for higher-order chromaticities were implemented to reduce the non-linearity of the machine as far as possible. A second set of measurements were then performed. All studies were performed using the LHC aperture kicker (MKA).

MD study of pyrimidine base damage on DNA and its recognition by repair enzyme

International Nuclear Information System (INIS)

Pinak, M.

2000-01-01

The molecular dynamics (MD) simulation was used on the study of two specific damages of pyrimidine bases of DNA. Pyrimidine bases are major targets either of free radicals induced by ionizing radiation in DNA surrounding environment or UV radiation. Thymine dimer (TD) is UV induced damage, in which two neighboring thymines in one strand are joined by covalent bonds of C(5)-C(5) and C(6)-C(6) atoms of thymines. Thymine glycol (TG) is ionizing radiation induced damage in which the free water radical adds to unsaturated bond C(5)-C(6) of thymine. Both damages are experimentally suggested to be mutagenetic and carcinogenic unless properly repaired by repair enzymes. In the case of MD of TD, there is detected strong kink around the TD site that is not observed in native DNA. In addition there is observed the different value of electrostatic energy at the TD site - negative '-10 kcal/mol', in contrary to nearly neutral value of native thymine site. Structural changes and specific electrostatic energy - seems to be important for proper recognition of TD damaged site, formation of DNA-enzyme complex and thus for subsequent repair of DNA. In the case of TG damaged DNA there is major structural distortion at the TG site, mainly the increased distance between TG and the C5' of adjacent nucleotide. This enlarged gap between the neighboring nucleotides may prevent the insertion of complementary base during replication causing the replication process to stop. In which extend this structural feature together with energy properties of TG contributes to the proper recognition of TG by repair enzyme Endonuclease III is subject of further computational MD study. (author)

LHC β*-reach MD: aperture measurements at small β*

CERN Document Server

Fuster Martinez, Nuria; Redaelli, Stefano; CERN. Geneva. ATS Department

2017-01-01

During this MD, performed on the 25th of July 2017, we measured the LHC aperture at top energy for β*=30 cm using the Transverse Damper (ADT) blow-up method. These measurements are part of the standard commissioning of an optics and have been performed in order to provide early on inputs for a possible change of β* later in 2017, as envisaged previously to fully profit from the additional margins introduced by the rematched phase advance between dump kickers and the TCTs (Target Collimator Tertiary). In addition to the aperture measurements, two other commissioning important tests were performed: loss maps for the nominal TCTs settings and an asynchronous dump validation with tighter TCT gaps.

75 FR 35611 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-10-10, DC-10-10F, and MD-10-10F...

Science.gov (United States)

2010-06-23

... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, and MD-10-10F Airplanes... certain McDonnell Douglas Model DC-10-10, DC-10-10F, and MD-10-10F airplanes. That NPRM was published in... amends Sec. 39.13 by adding the following new AD: 2010-13-06 McDonnell Douglas Corporation: Amendment 39...

MD simulation: determination of the physical properties and surface vaporization analysis of beryllium armours

International Nuclear Information System (INIS)

Prinzio, M. Di; Aquaro, D.

2006-01-01

The erosion of the divertor and of the first wall determined on the base of the anticipated operating conditions, is a critical issue that could affect the performance and the operating schedule of the nuclear fusion reactor ITER. This paper deals with the analysis of beryllium thermal properties by means of MD simulations, in order to better predict thermal behaviour of beryllium armoured PFCs in fusion devices. The importance of this analysis is clearly connected to thermal response evaluation of PFCs to high heat flux exposure, during off-normal events and Edge Localized Modes. The ensuing strong over-heating, in fact, produces material ablation through vaporization of surface material layers and possible loss of melting material. The overall PFCs erosion has bearings on plasma contamination, due to eroded material transport, and components lifetime, due to armour thickness reduction. An important feature of beryllium is its high vapour pressure. During thermal transients the strong vaporization keeps surface temperature relatively low but eroded thickness results high as well. Small changes in beryllium vapour pressure produce not negligible differences in thermal analyses results. On the basis of available force fields, classical Molecular Dynamics simulations have been carried out in order to better understand surface vaporization in tokamak conditions and to evaluate the effect of beryllium oxides formation. This effect has been successfully modelled by MD simulation, carried out with Moldy code. Morse stretching and bending potential for Be-O bond simulation have been used, and partial charges method, accounting for molecular polarity, has been employed. Since during short thermal transients, such as ELMs, only a few microns of Be armour will be overheated and reach melting threshold, the effective thermal conductivity is very important in determining the temperature evolution of surface layers and the ensuing erosion. Thermal conductivity can be evaluated

75 FR 66653 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-10-29

... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation...-15667 (73 FR 52203, September 9, 2008), and adding the following new AD: 2010-22-04 McDonnell Douglas... supersedes AD 2008-18-10, Amendment 39-15667. Applicability (c) This AD applies to McDonnell Douglas...

Development and Flight Test of an Augmented Thrust-Only Flight Control System on an MD-11 Transport Airplane

Science.gov (United States)

Burcham, Frank W., Jr.; Maine, Trindel A.; Burken, John J.; Pappas, Drew

1996-01-01

An emergency flight control system using only engine thrust, called Propulsion-Controlled Aircraft (PCA), has been developed and flight tested on an MD-11 airplane. In this thrust-only control system, pilot flight path and track commands and aircraft feedback parameters are used to control the throttles. The PCA system was installed on the MD-11 airplane using software modifications to existing computers. Flight test results show that the PCA system can be used to fly to an airport and safely land a transport airplane with an inoperative flight control system. In up-and-away operation, the PCA system served as an acceptable autopilot capable of extended flight over a range of speeds and altitudes. The PCA approaches, go-arounds, and three landings without the use of any non-nal flight controls have been demonstrated, including instrument landing system-coupled hands-off landings. The PCA operation was used to recover from an upset condition. In addition, PCA was tested at altitude with all three hydraulic systems turned off. This paper reviews the principles of throttles-only flight control; describes the MD-11 airplane and systems; and discusses PCA system development, operation, flight testing, and pilot comments.

Luminosity Anti-leveling with Crossing Angle (MD 1669)

CERN Document Server

Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

2016-01-01

A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

Multidimensional Recurrence Quantification Analysis (MdRQA) for the Analysis of Multidimensional Time-Series: A Software Implementation in MATLAB and Its Application to Group-Level Data in Joint Action.

Science.gov (United States)

Wallot, Sebastian; Roepstorff, Andreas; Mønster, Dan

2016-01-01

We introduce Multidimensional Recurrence Quantification Analysis (MdRQA) as a tool to analyze multidimensional time-series data. We show how MdRQA can be used to capture the dynamics of high-dimensional signals, and how MdRQA can be used to assess coupling between two or more variables. In particular, we describe applications of the method in research on joint and collective action, as it provides a coherent analysis framework to systematically investigate dynamics at different group levels-from individual dynamics, to dyadic dynamics, up to global group-level of arbitrary size. The Appendix in Supplementary Material contains a software implementation in MATLAB to calculate MdRQA measures.

75 FR 38056 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

Science.gov (United States)

2010-07-01

...-0645; Directorate Identifier 2009-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., September 9, 2008), for certain McDonnell Douglas Corporation Model MD-90-30 airplanes. That AD requires a... fasteners in the aft mount support fitting of the left and right engines on 29 McDonnell Douglas Corporation...

MD2723 - Amplitude Detuning Studies at 6.5 TeV with Various Configurations of the Crossing Scheme

CERN Document Server

Carlier, Felix Simon; Dilly, Joschua Werner; Fol, Elena; Garcia-Tabares Valdivieso, Ana; Maclean, Ewen Hamish; Malina, Lukas; Persson, Tobias Hakan Bjorn; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

2018-01-01

Particular interst exists to better understand the amplitude detuning through the LHC cycle in order to shed some light on possible sources of instabilities, and better prepair for the β* squeeze to 25cm in 2018. This note reports on the amplitude etuning measurements taken on the 3rd of December of 2017 during MD2723. Amplitude detuning measurements are presented at flattop with crossing angles and at end-of-squeeze with and without crossing angles. Furthermore tests of the skew octupolar corrections in IP5 done at the end of the MD are presented, with specific focus on forced DA and resonance driving terms measurements.

Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

KAUST Repository

Han, Gang; Zuo, Jian; Wan, Chunfeng; Chung, Neal Tai-Shung

2015-01-01

unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic

Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation

Directory of Open Access Journals (Sweden)

Yue Hou

2017-02-01

Full Text Available Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM experiments, Phase Dynamics Theory and Molecular Dynamics (MD Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation.

Science.gov (United States)

Hou, Yue; Wang, Linbing; Wang, Dawei; Guo, Meng; Liu, Pengfei; Yu, Jianxin

2017-02-21

Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM) experiments, Phase Dynamics Theory and Molecular Dynamics (MD) Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

78 FR 17996 - MCM Rail Services LLC-Petition for Retroactive Exemption-In Sparrows Point, Md.

Science.gov (United States)

2013-03-25

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35707] MCM Rail Services... regarding a petition for an operation exemption submitted by MCM Rail Services LLC (MCM) regarding 12 miles of rail line in Sparrows Point, Md. (the Line). DATES: MCM's supplemental information is due by April...

Orbit Feedback Operation with RCBX (MD 1209)

CERN Document Server

Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

2017-01-01

The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

Molecular epidemiology of Brucella genotypes in patients at a major hospital in central Peru

NARCIS (Netherlands)

Nöckler, Karsten; Maves, Ryan; Cepeda, David; Draeger, Angelika; Mayer-Scholl, Anne; Chacaltana, Jesus; Castañeda, María; Espinosa, Benjamin; Castillo, Rosa; Hall, Eric; Al Dahouk, Sascha; Gilman, Robert H.; Cabeza, Franco; Smits, Henk L.

2009-01-01

The multiple-locus variable-number repeat analysis of 90 human Brucella melitensis isolates from a large urban area in central Peru revealed variations at 4 (Bruce07, Bruce09, Bruce18, and Bruce42) out of 16 loci investigated, of which 1 (Bruce42) also is used for species identification. Ten

Overexpression of a Novel Apple NAC Transcription Factor Gene, MdNAC1, Confers the Dwarf Phenotype in Transgenic Apple (Malus domestica)

Science.gov (United States)

Jia, Dongfeng; Gong, Xiaoqing; Li, Mingjun; Li, Chao; Sun, Tingting

2018-01-01

Plant height is an important trait for fruit trees. The dwarf characteristic is commonly associated with highly efficient fruit production, a major objective when breeding for apple (Malus domestica). We studied the function of MdNAC1, a novel NAC transcription factor (TF) gene in apple related to plant dwarfing. Localized primarily to the nucleus, MdNAC1 has transcriptional activity in yeast cells. Overexpression of the gene results in a dwarf phenotype in transgenic apple plants. Their reduction in size is manifested by shorter, thinner stems and roots, and a smaller leaf area. The transgenics also have shorter internodes and fewer cells in the stems. Levels of endogenous abscisic acid (ABA) and brassinosteroid (BR) are lower in the transgenic plants, and expression is decreased for genes involved in the biosynthesis of those phytohormones. All of these findings demonstrate that MdNAC1 has a role in plants dwarfism, probably by regulating ABA and BR production. PMID:29702625

MD456: Monitoring of abort gap population with diamond particle detectors at the BGI in IP 4

CERN Document Server

Stein, Oliver

2016-01-01

In this MD, diamond based particle detectors (dBLM) were used for measuring showers of the beam interactions with the in the BGI induced neon gas. This setup was proposed in a feasibility study for using dBLMs at the BGI to measure the abort gap population by detecting the beam gas interactions. During the MD neon gas was induced in the BGI vacuum chamber to increase the interaction rate. Two nominal bunches were injected and accelerated up to 6.5 TeV. The measurements lasted for 140 minutes. The bunches could be clearly identified. But the resulting count rate of the beam gas interactions was a factor 70 lower than predicted by the feasibility study. In addition, a problem with the timing information lead to a widening of the histogram peaks.

78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

Science.gov (United States)

2013-02-15

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Connor Hayden Kraegel, 19917 Spurrier... Court, District of Maryland, Connor Hayden Kraegel (``Kraegel'') was convicted of violating Section 38... Hayden Kraegel, with a last known address at: 19917 Spurrier Avenue, Poolesville, MD 20837, and when...

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

Science.gov (United States)

Tanimura, Natsuko; Saitoh, Shin-Ichiroh; Ohto, Umeharu; Akashi-Takamura, Sachiko; Fujimoto, Yukari; Fukase, Koichi; Shimizu, Toshiyuki; Miyake, Kensuke

2014-06-01

TLR4/MD-2 senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes. Monophosphoryl lipid A (MPL), a detoxified derivative of lipid A, is weaker than lipid A in activating the MyD88-dependent pathway. Little is known, however, about mechanisms underlying the attenuated activation of MyD88-dependent pathways. We here show that MPL was impaired in induction of CD14-dependent TLR4/MD-2 dimerization compared with lipid A. Impaired TLR4/MD-2 dimerization decreased CD14-mediated TNFα production. In contrast, MPL was comparable to lipid A in CD14-independent MyD88-dependent TNFα production and TRIF-dependent responses including cell surface CD86 up-regulation and IFNβ induction. Although CD86 up-regulation is dependent on TRIF signaling, it was induced by TLR4/MD-2 at the plasma membrane. These results revealed that the attenuated MPL responses were due to CD14-initiated responses at the plasma membrane, but not just to responses initiated by MyD88, that is, MPL was specifically unable to induce CD14-dependent TLR4/MD-2 dimerization that selectively enhances MyD88-mediated responses at the plasma membrane. © The Japanese Society for Immunology. 2013. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Prediction of Osmotic Pressure of Ionic Liquids Inside a Nanoslit by MD Simulation and Continuum Approach

Science.gov (United States)

Moon, Gi Jong; Yang, Yu Dong; Oh, Jung Min; Kang, In Seok

2017-11-01

Osmotic pressure plays an important role in the processes of charging and discharging of lithium batteries. In this work, osmotic pressure of the ionic liquids confined inside a nanoslit is calculated by using both MD simulation and continuum approach. In the case of MD simulation, an ionic liquid is modeled as singly charged spheres with a short-ranged repulsive Lennard-Jones potential. The radii of the spheres are 0.5nm, reflecting the symmetry of ion sizes for simplicity. The simulation box size is 11nm×11nm×7.5nm with 1050 ion pairs. The concentration of ionic liquid is about 1.922mol/L, and the total charge on an individual wall varies from +/-60e(7.944 μm/cm2) to +/-600e(79.44 μm/cm2) . In the case of continuum approach, we classify the problems according to the correlation length and steric factor, and considered the four separate cases: 1) zero correlation length and zero steric factor, 2) zero correlation length and non-zero steric factor, 3) non-zero correlation length and zero steric factor, and 4) non-zero correlation and non-zero steric factor. Better understanding of the osmotic pressure of ionic liquids confined inside a nanoslit can be achieved by comparing the results of MD simulation and continuum approach. This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP: Ministry of Science, ICT & Future Planning) (No. 2017R1D1A1B05035211).

Jules Stein, MD: Ophthalmologist, Entertainment Magnate, and Advocate for Vision.

Science.gov (United States)

Straatsma, Bradley R; Weeks, David F

2016-04-01

To report the lifetime activities and accomplishments of Jules Stein, MD. Retrospective review. Assessment of published and unpublished biographical material. Jules Stein combined his love of music and medicine with organizational skills to achieve successive careers as a musician, an ophthalmologist, an entertainment magnate, and an advocate for vision. To preserve vision, he founded Research to Prevent Blindness, founded the Jules Stein Eye Institute at the University of California, Los Angeles, and led a multiyear campaign to establish the National Eye Institute. With successive careers and extraordinary achievements, Jules Stein created an enduring legacy of benefits to ophthalmology, vision research, and the prevention of blindness. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

Science.gov (United States)

2010-04-13

...-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS... zone on the Atlantic Ocean in the vicinity of Ocean City, Maryland to support the Ocean City Air Show. This action is intended to restrict vessel traffic movement on the Atlantic Ocean to protect mariners...

A hybrid liquid-phase precipitation (LPP) process in conjunction with membrane distillation (MD) for the treatment of the INEEL sodium-bearing liquid waste.

Science.gov (United States)

Bader, M S H

2005-05-20

A novel hybrid system combining liquid-phase precipitation (LPP) and membrane distillation (MD) is integrated for the treatment of the INEEL sodium-bearing liquid waste. The integrated system provides a "full separation" approach that consists of three main processing stages. The first stage is focused on the separation and recovery of nitric acid from the bulk of the waste stream using vacuum membrane distillation (VMD). In the second stage, polyvalent cations (mainly TRU elements and their fission products except cesium along with aluminum and other toxic metals) are separated from the bulk of monovalent anions and cations (dominantly sodium nitrate) by a front-end LPP. In the third stage, MD is used first to concentrate sodium nitrate to near saturation followed by a rear-end LPP to precipitate and separate sodium nitrate along with the remaining minor species from the bulk of the aqueous phase. The LPP-MD hybrid system uses a small amount of an additive and energy to carry out the treatment, addresses multiple critical species, extracts an economic value from some of waste species, generates minimal waste with suitable disposal paths, and offers rapid deployment. As such, the LPP-MD could be a valuable tool for multiple needs across the DOE complex where no effective or economic alternatives are available.

Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

Directory of Open Access Journals (Sweden)

Karim Shahbazi

2017-08-01

Full Text Available In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function units and two data buses. It has also two types of 32-bit instruction formats for executing Memory Reference (M.R., Register Reference (R.R., and Input/Output Reference (I/O R. instructions. The maximum achieved frequency is 166.916 MHz. The encoded output results of the encryption process of a 128-bit input block are obtained after 122, 146 and 170 clock cycles for AES-128, AES-192, and AES-256, respectively. Moreover, it takes 95 clock cycles to encrypt or decrypt a 64-bit input block by using IDEA. Finally, the MD5 hash algorithm requires 469 clock cycles to generate the coded outputs for a block of 512 bits. The performance of the proposed processor is compared to some previous and state-of-the-art implementations in terms of speed, latency, throughput, and flexibility.

Alpha-gamma decay studies of 253No and its daughter products 253Md, 249Fm

International Nuclear Information System (INIS)

Hessberger, F.P.; Antalic, S.; Kalaninova, Z.; Saro, S.; Venhart, M.; Ackermann, D.; Heinz, S.; Kindler, B.; Kojouharov, I.; Kuusiniemi, P.; Lommel, B.; Mann, R.; Sulignano, B.; Hofmann, S.; Streicher, B.; Leino, M.; Nishio, K.

2012-01-01

Nuclear structure and decay of the isotope 253 No and its decay products 249 Fm and 253 Md were investigated by means of α - γ spectroscopy. Besides the established strong γ transitions from the 9/2 - [734] Nilsson level in 249 Fm, populated predominantly by the α decay of 253 No, into the ground-state (gs) rotational band, a couple of weaker γ lines (58.3, 129.2, 209.3 and 669.5keV) were observed and placed into the 249 Fm level scheme. The transition from the 7/2 - level in 249 Es, populated by the α decay of 253 Md, into the 9/2 + member of the gs rotational band, so far established for other odd-mass Es isotopes, was observed clearly. GEANT4 simulations were performed to investigate the influence of energy summing between α particles and conversion electrons (CE) on the shape of the α spectra at different implantation energies, leading to evidence for a weak α decay branch of 253 No into the gs of 249 Fm or the ground-state rotational band, respectively. (orig.)

MD simulation of cluster formation during sputtering

International Nuclear Information System (INIS)

Muramoto, T.; Okai, M.; Yamashita, Y.; Yorizane, K.; Yamamura, Y.

2001-01-01

The cluster ejection due to cluster impact on a solid surface is studied through molecular dynamics (MD) simulations. Simulations are performed for Cu cluster impacts on the Cu(1 1 1) surface for cluster energy 100 eV/atom, and for clusters of 6, 13, 28 and 55 atoms. Interatomic interactions are described by the AMLJ-EAM potential. The vibration energy spectrum is independent of the incident cluster size and energy. This comes from the fact that sputtered clusters become stable through the successive fragmentation of nascent large sputtered clusters. The vibration energy spectra for large sputtered clusters have a peak, whose energy corresponds to the melting temperature of Cu. The exponent of the power-law fit of the abundance distribution and the total sputtering yield for the cluster impacts are higher than that for the monatomic ion impacts with the same total energy, where the exponent δ is given by Y n ∝n δ and Y n is the yield of sputtered n-atom cluster. The exponent δ follows a unified function of the total sputtering yield, which is a monotonic increase function, and it is nearly equal to δ ∼ -3 for larger yield

Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

Science.gov (United States)

Rallabhandi, Prasad; Phillips, Rachel L.; Boukhvalova, Marina S.; Pletneva, Lioubov M.; Shirey, Kari Ann; Gioannini, Theresa L.; Weiss, Jerrold P.; Chow, Jesse C.; Hawkins, Lynn D.; Vogel, Stefanie N.; Blanco, Jorge C. G.

2012-01-01

ABSTRACT Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-dependent manner. TLR4 signaling by LPS also requires the presence of an additional protein, MD-2. Thus, it is possible that F protein-mediated TLR4 activation relies on MD-2 as well, although this hypothesis has not been formally tested. LPS-free RSV F protein was found to activate NF-κB in HEK293T transfectants that express wild-type (WT) TLR4 and CD14, but only when MD-2 was coexpressed. These findings were confirmed by measuring F-protein-induced interleukin 1β (IL-1β) mRNA in WT versus MD-2−/− macrophages, where MD-2−/− macrophages failed to show IL-1β expression upon F-protein treatment, in contrast to the WT. Both Rhodobacter sphaeroides LPS and synthetic E5564 (eritoran), LPS antagonists that inhibit TLR4 signaling by binding a hydrophobic pocket in MD-2, significantly reduced RSV F-protein-mediated TLR4 activity in HEK293T-TLR4–CD14–MD-2 transfectants in a dose-dependent manner, while TLR4-independent NF-κB activation by tumor necrosis factor alpha (TNF-α) was unaffected. In vitro coimmunoprecipitation studies confirmed a physical interaction between native RSV F protein and MD-2. Further, we demonstrated that the N-terminal domain of the F1 segment of RSV F protein interacts with MD-2. These data provide new insights into the importance of MD-2 in RSV F-protein-mediated TLR4 activation. Thus, targeting the interaction between MD-2 and RSV F protein may potentially lead to novel therapeutic approaches to help control RSV-induced inflammation and pathology. PMID:22872782

A workshop on leadership for MD/PhD students

Directory of Open Access Journals (Sweden)

Mark D. Cannon

2011-08-01

Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

Synergistic Applications of MD and NMR for the Study of Biological Systems

Directory of Open Access Journals (Sweden)

Olivier Fisette

2012-01-01

same time, theoretical and computational approaches gain in reliability and their field of application widens. In this short paper, we discuss recent advances in the areas of solution nuclear magnetic resonance (NMR spectroscopy and molecular dynamics (MD simulations that were made possible by the combination of both methods, that is, through their synergistic use. We present the main NMR observables and parameters that can be computed from simulations, and how they are used in a variety of complementary applications, including dynamics studies, model-free analysis, force field validation, and structural studies.

Measuring Health Information Dissemination and Identifying Target Interest Communities on Twitter: Methods Development and Case Study of the @SafetyMD Network.

Science.gov (United States)

Kandadai, Venk; Yang, Haodong; Jiang, Ling; Yang, Christopher C; Fleisher, Linda; Winston, Flaura Koplin

2016-05-05

Little is known about the ability of individual stakeholder groups to achieve health information dissemination goals through Twitter. This study aimed to develop and apply methods for the systematic evaluation and optimization of health information dissemination by stakeholders through Twitter. Tweet content from 1790 followers of @SafetyMD (July-November 2012) was examined. User emphasis, a new indicator of Twitter information dissemination, was defined and applied to retweets across two levels of retweeters originating from @SafetyMD. User interest clusters were identified based on principal component analysis (PCA) and hierarchical cluster analysis (HCA) of a random sample of 170 followers. User emphasis of keywords remained across levels but decreased by 9.5 percentage points. PCA and HCA identified 12 statistically unique clusters of followers within the @SafetyMD Twitter network. This study is one of the first to develop methods for use by stakeholders to evaluate and optimize their use of Twitter to disseminate health information. Our new methods provide preliminary evidence that individual stakeholders can evaluate the effectiveness of health information dissemination and create content-specific clusters for more specific targeted messaging.

75 FR 31509 - Rescinding the Notice of Intent for an Environmental Impact Statement: Prince George's County, MD

Science.gov (United States)

2010-06-03

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Rescinding the Notice of Intent for an Environmental Impact Statement: Prince George's County, MD AGENCY: Federal Highway Administration. ACTION... Statement that was issued on June 11, 2008, for a proposed roadway improvement project in Prince George's...

Theoretical analysis of the domain-swapped dimerization of cytochrome c: An MD and 3D-RISM approach

Science.gov (United States)

Yoshida, Norio; Higashi, Masahiro; Motoki, Hideyoshi; Hirota, Shun

2018-01-01

The structural stability of a cytochrome c domain-swapped dimer compared with that of the monomer was investigated by molecular dynamics (MD) simulations and by three-dimensional reference interaction site model (3D-RISM) theory. The structural fluctuation and structural energy of cytochrome c were treated by MD simulations, and the solvation thermodynamics was treated by 3D-RISM theory. The domain-swapped dimer state is slightly less stable than the monomer state, which is consistent with experimental observations; the total free energy difference is calculated as 25 kcal mol-1. The conformational change and translational/rotational entropy change contribute to the destabilization of the dimer, whereas the hydration and vibrational entropy contribute to the stabilization. Further analyses on the residues located at the hinge loop for swapping were conducted, and the results reveal details at the molecular level of the structural and interaction changes upon dimerization.

The Information Content of Note Disclosures and MD&A Information in the Financial Report – A Study of Market Reactions in Denmark

DEFF Research Database (Denmark)

Thinggaard, Frank; Sønderby Jeppesen, Carsten; Madsen, Kasper

2015-01-01

The preparation of disclosures in the financial report constitutes a significant cost to most companies, but do the disclosures have information content to investors? This paper examines stock market reactions to the release of note disclosures and MD&A (management discussion and analysis......) information. The study is based on data from the Danish capital market in 2006-2009 because here it is largely possible to isolate the release of such information from other information in the financial report. The primary results suggest that for some companies, note disclosures and information in the MD...

Fission of 255,256Es, 255-257Fm, and 258Md at moderate excitation energies

NARCIS (Netherlands)

Britt, H.C.; Hoffman, D.C.; Plicht, J. van der; Wilhelmy, J.; Cheifetz, E.; Dupzyk, R.J.; Lougheed, R.W.

1984-01-01

The fission of 255,256Es, 255-257Fm, and 258Md has been studied in the excitation energy range from threshold to 25 MeV. A target of 254Es was used in the direct reaction studies; (d,pf), (t,pf), (3He,df), (3He,pf), and in the compound induced fission reactions formed with p, d, t, and α particle

Using design science and artificial intelligence to improve health communication: ChronologyMD case example.

Science.gov (United States)

Neuhauser, Linda; Kreps, Gary L; Morrison, Kathleen; Athanasoulis, Marcos; Kirienko, Nikolai; Van Brunt, Deryk

2013-08-01

This paper describes how design science theory and methods and use of artificial intelligence (AI) components can improve the effectiveness of health communication. We identified key weaknesses of traditional health communication and features of more successful eHealth/AI communication. We examined characteristics of the design science paradigm and the value of its user-centered methods to develop eHealth/AI communication. We analyzed a case example of the participatory design of AI components in the ChronologyMD project intended to improve management of Crohn's disease. eHealth/AI communication created with user-centered design shows improved relevance to users' needs for personalized, timely and interactive communication and is associated with better health outcomes than traditional approaches. Participatory design was essential to develop ChronologyMD system architecture and software applications that benefitted patients. AI components can greatly improve eHealth/AI communication, if designed with the intended audiences. Design science theory and its iterative, participatory methods linked with traditional health communication theory and methods can create effective AI health communication. eHealth/AI communication researchers, developers and practitioners can benefit from a holistic approach that draws from theory and methods in both design sciences and also human and social sciences to create successful AI health communication. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

International Nuclear Information System (INIS)

Park, Sun Hong; Kyeong, Min Sik; Hwang, Yuri; Ryu, Shi Yong; Han, Sang-Bae; Kim, Youngsoo

2012-01-01

Highlights: ► 1-Dehydro-10-gingerdione (1D10G) from ginger inhibits LPS binding to MD-2. ► 1D10G suppresses MyD88- or TRIF-dependent signaling in LPS-activated macrophages. ► 1D10G down-regulates the expression of NF-κB-, AP1- or IRF3-target genes. ► MD-2 is a molecular target in the anti-inflammatory action of 1D10G. -- Abstract: Myeloid differentiation protein 2 (MD-2) is a co-receptor of toll-like receptor 4 (TLR4) for innate immunity. Here, we delineated a new mechanism of 1-dehydro-10-gingerdione (1D10G), one of pungent isolates from ginger (Zingiber officinale), in the suppression of lipopolysaccharide (LPS)-induced gene expression of inflammatory cytokines. 1D10G inhibited LPS binding to MD-2 with higher affinity than gingerol and shogaol from dietary ginger. Moreover, 1D10G down-regulated TLR4-mediated expression of nuclear factor-κB (NF-κB) or activating protein 1 (AP1)-target genes such as tumor necrosis factor α (TNF-α) and interleukin-1β, as well as those of interferon (IFN) regulatory factor 3 (IRF3)-target IFN-β gene and IFN-γ inducible protein 10 (IP-10) in LPS-activated macrophages. Taken together, MD-2 is a molecular target in the anti-inflammatory action of 1D10G.

Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

Energy Technology Data Exchange (ETDEWEB)

Park, Sun Hong; Kyeong, Min Sik; Hwang, Yuri [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Daejeon 305-600 (Korea, Republic of); Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo, E-mail: youngsoo@chungbuk.ac.kr [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)

2012-03-23

Highlights: Black-Right-Pointing-Pointer 1-Dehydro-10-gingerdione (1D10G) from ginger inhibits LPS binding to MD-2. Black-Right-Pointing-Pointer 1D10G suppresses MyD88- or TRIF-dependent signaling in LPS-activated macrophages. Black-Right-Pointing-Pointer 1D10G down-regulates the expression of NF-{kappa}B-, AP1- or IRF3-target genes. Black-Right-Pointing-Pointer MD-2 is a molecular target in the anti-inflammatory action of 1D10G. -- Abstract: Myeloid differentiation protein 2 (MD-2) is a co-receptor of toll-like receptor 4 (TLR4) for innate immunity. Here, we delineated a new mechanism of 1-dehydro-10-gingerdione (1D10G), one of pungent isolates from ginger (Zingiber officinale), in the suppression of lipopolysaccharide (LPS)-induced gene expression of inflammatory cytokines. 1D10G inhibited LPS binding to MD-2 with higher affinity than gingerol and shogaol from dietary ginger. Moreover, 1D10G down-regulated TLR4-mediated expression of nuclear factor-{kappa}B (NF-{kappa}B) or activating protein 1 (AP1)-target genes such as tumor necrosis factor {alpha} (TNF-{alpha}) and interleukin-1{beta}, as well as those of interferon (IFN) regulatory factor 3 (IRF3)-target IFN-{beta} gene and IFN-{gamma} inducible protein 10 (IP-10) in LPS-activated macrophages. Taken together, MD-2 is a molecular target in the anti-inflammatory action of 1D10G.

MD-11 PCA - View of aircraft on ramp

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 is taxiing to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

Steinberg ``AUDIOMAPS'' Music Appreciation-Via-Understanding: Special-Relativity + Expectations ``Quantum-Theory'': a Quantum-ACOUSTO/MUSICO-Dynamics (QA/MD)

Science.gov (United States)

Fender, Lee; Steinberg, Russell; Siegel, Edward Carl-Ludwig

2011-03-01

Steinberg wildly popular "AUDIOMAPS" music enjoyment/appreciation-via-understanding methodology, versus art, music-dynamics evolves, telling a story in (3+1)-dimensions: trails, frames, timbres, + dynamics amplitude vs. music-score time-series (formal-inverse power-spectrum) surprisingly closely parallels (3+1)-dimensional Einstein(1905) special-relativity "+" (with its enjoyment-expectations) a manifestation of quantum-theory expectation-values, together a music quantum-ACOUSTO/MUSICO-dynamics(QA/MD). Analysis via Derrida deconstruction enabled Siegel-Baez "Category-Semantics" "FUZZYICS"="CATEGORYICS ('TRIZ") Aristotle SoO DEduction , irrespective of Boon-Klimontovich vs. Voss-Clark[PRL(77)] music power-spectrum analysis sampling-time/duration controversy: part versus whole, shows QA/MD reigns supreme as THE music appreciation-via-analysis tool for the listener in musicology!!! Connection to Deutsch-Hartmann-Levitin[This is Your Brain on Music, (06)] brain/mind-barrier brain/mind-music connection is subtle/compelling/immediate!!!

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor

Directory of Open Access Journals (Sweden)

Sandra Posch

2016-09-01

Full Text Available We here give information for a deeper understanding of single molecule force spectroscopy (SMFS data through the example of the blood protein von Willebrand factor (VWF. It is also shown, how fitting of rupture forces versus loading rate profiles in the molecular dynamics (MD loading-rate range can be used to demonstrate the qualitative agreement between SMFS and MD simulations. The recently developed model by Bullerjahn, Sturm, and Kroy (BSK was used for this demonstration. Further, Brownian dynamics (BD simulations, which can be utilized to estimate the lifetimes of intramolecular VWF interactions under physiological shear, are described. For interpretation and discussion of the methods and data presented here, we would like to directly point the reader to the related research paper, “Mutual A domain interactions in the force sensing protein von Willebrand Factor” (Posch et al., 2016 [1]. Keywords: Atomic force microscopy, Single molecule force spectroscopy, Molecular dynamics simulation, Brownian dynamics simulation, von Willebrand factor

Development and Flight Test of an Emergency Flight Control System Using Only Engine Thrust on an MD-11 Transport Airplane

Science.gov (United States)

Burcham, Frank W., Jr.; Burken, John J.; Maine, Trindel A.; Fullerton, C. Gordon

1997-01-01

An emergency flight control system that uses only engine thrust, called the propulsion-controlled aircraft (PCA) system, was developed and flight tested on an MD-11 airplane. The PCA system is a thrust-only control system, which augments pilot flightpath and track commands with aircraft feedback parameters to control engine thrust. The PCA system was implemented on the MD-11 airplane using only software modifications to existing computers. Results of a 25-hr flight test show that the PCA system can be used to fly to an airport and safely land a transport airplane with an inoperative flight control system. In up-and-away operation, the PCA system served as an acceptable autopilot capable of extended flight over a range of speeds, altitudes, and configurations. PCA approaches, go-arounds, and three landings without the use of any normal flight controls were demonstrated, including ILS-coupled hands-off landings. PCA operation was used to recover from an upset condition. The PCA system was also tested at altitude with all three hydraulic systems turned off. This paper reviews the principles of throttles-only flight control, a history of accidents or incidents in which some or all flight controls were lost, the MD-11 airplane and its systems, PCA system development, operation, flight testing, and pilot comments.

LHC MD 1087: Controlled Longitudinal Emittance Blow-up with Short Bunches

CERN Document Server

Timko, Helga; Esteban Muller, Juan; Jaussi, Michael; Lasheen, Alexandre; Shaposhnikova, Elena; CERN. Geneva. ATS Department

2017-01-01

The aim of the MD was to study the controlled longitudinal emittance blow-up applied during the ramp with bunches that are slightly shorter than operational. Earlier MDs in 2015 have shown that with a short target bunch length, the blow-up is less controlled and a bifurcation of bunch lengths occurs. The presented measurements show that the bifurcation is independent of the presence of the bunch length feedback, pointing towards an intensity-dependent phenomenon, originating from a synchrotron frequency shift with intensity. Accurate measurements of synchrotron frequency shift with intensity are presented as well. The measurements took place between 22nd August 2016, 19:00 and 23rd August 2016, 04:00.

Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

International Nuclear Information System (INIS)

Ding Yinfeng; Zhang Zhibin; Ke Xuezhi; Zhu Zhiyuan; Zhu Dezhang; Wang Zhenxia; Xu Hongjie

2005-01-01

The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

Cultivating social learning spaces at an urban Johannesburg university student residence

OpenAIRE

Agherdien, Najma

2015-01-01

Ph.D. (Education) This case study investigated the conceptualisation and implementation of social learning spaces (SLS) in a University of Johannesburg student residence. The literature base I drew on included ideas, concepts and constructs associated with learning communities [where the terms ‘SLS’ and ‘learning communities’ (LCs) are often used interchangeably], Wenger’s communities of practice, the First Year Experience (FYE), university student residence life and transformation in high...

Structural and dynamical aspects of Streptococcus gordonii FabH through molecular docking and MD simulations.

Science.gov (United States)

Shamim, Amen; Abbasi, Sumra Wajid; Azam, Syed Sikander

2015-07-01

β-Ketoacyl-ACP-synthase III (FabH or KAS III) has become an attractive target for the development of new antibacterial agents which can overcome the multidrug resistance. Unraveling the fatty acid biosynthesis (FAB) metabolic pathway and understanding structural coordinates of FabH will provide valuable insights to target Streptococcus gordonii for curing oral infection. In this study, we designed inhibitors against therapeutic target FabH, in order to block the FAB pathway. As compared to other targets, FabH has more interactions with other proteins, located on the leading strand with higher codon adaptation index value and associated with lipid metabolism category of COG. Current study aims to gain in silico insights into the structural and dynamical aspect of S. gordonii FabH via molecular docking and molecular dynamics (MD) simulations. The FabH protein is catalytically active in dimerization while it can lock in monomeric state. Current study highlights two residues Pro88 and Leu315 that are close to each other by dimerization. The active site of FabH is composed of the catalytic triad formed by residues Cys112, His249, and Asn279 in which Cys112 is involved in acetyl transfer, while His249 and Asn279 play an active role in decarboxylation. Docking analysis revealed that among the studied compounds, methyl-CoA disulfide has highest GOLD score (82.75), binding affinity (-11 kcal/mol) and exhibited consistently better interactions. During MD simulations, the FabH structure remained stable with the average RMSD value of 1.7 Å and 1.6 Å for undocked protein and docked complex, respectively. Further, crucial hydrogen bonding of the conserved catalytic triad for exhibiting high affinity between the FabH protein and ligand is observed by RDF analysis. The MD simulation results clearly demonstrated that binding of the inhibitor with S. gordonii FabH enhanced the structure and stabilized the dimeric FabH protein. Therefore, the inhibitor has the potential to become

ComVisMD - compact visualization of multidimensional data: experimenting with cricket players data

Science.gov (United States)

Dandin, Shridhar B.; Ducassé, Mireille

2018-03-01

Database information is multidimensional and often displayed in tabular format (row/column display). Presented in aggregated form, multidimensional data can be used to analyze the records or objects. Online Analytical database Processing (OLAP) proposes mechanisms to display multidimensional data in aggregated forms. A choropleth map is a thematic map in which areas are colored in proportion to the measurement of a statistical variable being displayed, such as population density. They are used mostly for compact graphical representation of geographical information. We propose a system, ComVisMD inspired by choropleth map and the OLAP cube to visualize multidimensional data in a compact way. ComVisMD displays multidimensional data like OLAP Cube, where we are mapping an attribute a (first dimension, e.g. year started playing cricket) in vertical direction, object coloring based on b (second dimension, e.g. batting average), mapping varying-size circles based on attribute c (third dimension, e.g. highest score), mapping numbers based on attribute d (fourth dimension, e.g. matches played). We illustrate our approach on cricket players data, namely on two tables Country and Player. They have a large number of rows and columns: 246 rows and 17 columns for players of one country. ComVisMD’s visualization reduces the size of the tabular display by a factor of about 4, allowing users to grasp more information at a time than the bare table display.

The brain and the biology of belief: An interview with Andrew Newberg, MD. Interview by Nancy Nachman-Hunt.

Science.gov (United States)

Newberg, Andrew

2009-01-01

Andrew Newberg, MD, is an associate professor in the Department of Radiology, Division of Nuclear Medicine, at the Hospital of the University of Pennsylvania, Philadelphia, with secondary appointments in the Departments of Psychiatry and Religious Studies. He is actively involved in neuroimaging research projects, including the study of the neurophysiological correlates of meditation and other types of complementary therapies. Dr Newberg's research now largely focuses on how brain function is associated with various mental states, in particular, the relationship between brain function and mystical or religious experiences. He has authored several books, including Why God Won't Go Away: Brain Science and the Biology of Belief (Ballantine/Random House, 2001) and coauthor with Eugene G. d'Aquili, MD, of The Mystical Mind: Probing the Biology of Religious Experience (Fortress Press, 1999). His most recent book is How God Changes Your Brain, with coauthor Mark Waldman (Ballantine Books, 2009).

Steinberg ``AUDIOMAPS" Music Appreciation-Via-Understanding: Special-Relativity + Expectations "Quantum-Theory": a Quantum-ACOUSTO/MUSICO-Dynamics (QA/MD)

Science.gov (United States)

Steinberg, R.; Siegel, E.

2010-03-01

``AUDIOMAPS'' music enjoyment/appreciation-via-understanding methodology, versus art, music-dynamics evolves, telling a story in (3+1)-dimensions: trails, frames, timbres, + dynamics amplitude vs. music-score time-series (formal-inverse power- spectrum) surprisingly closely parallels (3+1)-dimensional Einstein(1905) special-relativity ``+'' (with its enjoyment- expectations) a manifestation of quantum-theory expectation- values, together a music quantum-ACOUSTO/MUSICO-dynamics (QA/MD). Analysis via Derrida deconstruction enabled Siegel- Baez ``Category-Semantics'' ``FUZZYICS''=``CATEGORYICS (``SON of 'TRIZ") classic Aristotle ``Square-of-Opposition" (SoO) DEduction-logic, irrespective of Boon-Klimontovich versus Voss- Clark[PRL(77)] music power-spectrum analysis sampling- time/duration controversy: part versus whole, shows that ``AUDIOMAPS" QA/MD reigns supreme as THE music appreciation-via- analysis tool for the listener in musicology!!! Connection to Deutsch-Hartmann-Levitin[This is Your Brain on Music,(2006)] brain/mind-barrier brain/mind-music connection is both subtle and compelling and immediate!!!

The post irradiation examination of fuel in support of Bruce A nuclear division fueling with flow program

International Nuclear Information System (INIS)

Montin, J.; Sagat, S.; Day, R.; Novak, J.; Bromfield, H.

1995-01-01

Bruce A Nuclear Division (BAND) units are operating at ∼ 75% of full power, because of the potential of a power pulse in the event of an inlet header break. As a result, BAND is converting to fueling with flow, to eliminate the potential of a power pulse and to allow for full-power operation. Concerns regarding the integrity of the end-of-life (EOL) bundles interacting with the latch at the downstream end of the fuel channel were raised. BAND carried out a test program in which EOL bundles in the upstream position 13 of Unit 2 were cascaded into the downstream latch position 1 of another channel. Six of twelve cascaded bundles and two typical EOL position 13 (benchmark) bundles were selected for post-irradiation examination (PIE). Incipient cracks were found in the assembly welds (endplateto-endcap welds) of all six cascaded bundles. No incipient cracks were found in the benchmark bundles. Metallographic and fractographic examination, along with crack dating, and hydrogen and deuterium analyses, indicated that the incipient cracks were the result of delayed-hydride assisted cracking at the EOL. Consequently, Ontario Hydro changed the design of the outlet shield plug to support all three rings of the fuel bundle, to minimize stress and prevent endplate cracking. Also, an ultrasonic endplate inspection tool (UT) was developed and located in the fuel bay. to inspect fuelbundle endplates for cracks. A second test was done involving a series of four bundle cascades in BAND Unit 4 channels that had new outlet shield plugs. The latch bundles were discharged after a hot shutdown. The cascaded Unit 2 and Unit 4 latch bundles were checked for cracks using the UT. The PIE found incipient cracks or less-than-ideal welds in the assembly welds of fuel elements from Unit 2 (latch-supported fuel bundles) that had been identified by the UT as having incipient cracks. No incipient cracks were found in the assembly welds of fuel elements from Unit 4 (new outlet shield

The post-irradiation examination of fuel in support of Bruce A Nuclear Division fueling with flow program

International Nuclear Information System (INIS)

Montin, J.; Sagat, S.

1995-10-01

Bruce A Nuclear Division (BAND) units are operating at ∼ 75% of full power, because of the potential of a power pulse in the event of an inlet header break. As a result, BAND is converting to fueling with flow, to eliminate the potential of a power pulse and to allow for full-power operation. Concerns regarding the integrity of the end-of-life (EOL) bundles interacting with the latch at the downstream end of the fuel channel were raised. BAND carried out a test program in which EOL bundles in the upstream position of 13 of Unit 2 were cascaded into the downstream latch position 1 of another channel. Six of twelve cascaded bundles and two typical EOL position 13 (benchmark) bundles were selected for post-irradiation examination (PIE). Incipient cracks were found in the benchmark bundles. Metallographic and fractographic examination, along with crack dating, and hydrogen and deuterium analyses, indicated that the incipient cracks were the result of delayed-hydride assisted cracking at the EOL. Consequently, Ontario Hydro changed the design of the outlet shield plug to support all three rings of the fuel bundle, to minimize stress and prevent end plate cracking. Also, an ultrasonic end plate inspection tool (UT) was developed and located in the fuel bay, to inspect fuel-bundle end plates for cracks. A second test was done involving a series of four bundle cascades in BAND Unit 4 channels that had new outlet shield plugs. The latch bundles were discharged after a hot shutdown. The cascaded Unite 2 and Unit 4 latch bundles were checked for cracks using the UT. The PIE found incipient cracks or less-than-ideal welds in the assembly welds of fuel elements from Unit 2 (latch-supported fuel bundles) that had been identified by the UT as having incipient cracks. No incipient cracks were found in the assemble welds of fuel elements from Unit 4 (new outlet shield-supported fuel bundles) confirming the UT results. (author). 5 refs., 8 figs

Medicinal Cannabis in California: An Interview with Igor Grant, MD.

Science.gov (United States)

Piomelli, Daniele; Grant, Igor

2016-01-01

Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research at the University of California, San Diego. Dr. Grant is a neuropsychiatrist who graduated from the University of British Columbia School of Medicine (1966), and received specialty training in psychiatry at the University of Pennsylvania (1967-1971), and additional training in neurology at the Institute of Neurology (1980-1981), London, U.K. Dr. Grant's academic interests focus on the effects of various diseases on brain and behavior, with an emphasis on translational studies in HIV, and drugs of abuse. He has contributed to ∼700 scholarly publications and is principal investigator of several NIH studies, including an NIDA P50 (Translational Methamphetamine AIDS Research Center-TMARC), and is codirector of the HIV Neurobehavioral Research Center (HNRC).

75 FR 30296 - Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD

Science.gov (United States)

2010-06-01

... safety of life on navigable waters during the event. DATES: This rule is effective from 5:30 a.m. to 2:30...-AA08 Special Local Regulation for Marine Event; Maryland Swim for Life, Chester River, Chestertown, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is temporarily changing...

Color Doppler, power Doppler and B-flow ultrasound in the assessment of ICA stenosis: Comparison with 64-MD-CT angiography

International Nuclear Information System (INIS)

Clevert, D.A.; Johnson, T.; Flach, P.M.; Strautz, T.I.; Becker, C.; Reiser, M.; Jung, E.M.; Ritter, G.; Gallegos, M.T.; Kubale, R.

2007-01-01

The purpose of this study is to investigate the diagnostic potential of color-coded Doppler sonography (CCDS), power-Doppler (PD) and B-flow ultrasound in assessing the degree of extracranial internal carotid artery (ICA) stenosis in comparison to CT-angiography (MD-CTA). Thirty-two consecutive patients referred for CTA with 41 ICA-stenoses were included in this prospective study. MD-CTA was performed using a 64 row scanner with a CTDIvol of 13.1 mGy/cm. In CTA, CCDS, PD and B-flow, the degree of stenosis was evaluated by the minimal intrastenotic diameter in comparison to the poststenotic diameter. Two radiologists performed a quantitative evaluation of the stenoses in consensus blinded to the results of ultrasound. These were correlated to CTA, CCDS, PD and B-flow, intraoperative findings and clinical follow-up. Grading of the stenoses in B-flow ultrasound outperformed the other techniques in terms of accuracy with a correlation coefficient to CTA of 0.88, while PD and CCDS measurements yield coefficients of 0.74 and 0.70. Bland-Altman analysis additionally shows a very little bias of the three US methods between 0.5 and 3.2 %. There is excellent correlation (coefficient 0.88, CI 0.77-0.93) with 64-MD-CTA and B-flow ultrasound in terms of accuracy for intrastenotic and poststenotic diameter. Duplex sonography is useful for screening purposes. (orig.)

Shallow boron dopant on silicon An MD study

International Nuclear Information System (INIS)

Perez-Martin, A. Mari Carmen; Jimenez-Rodriguez, Jose J.; Jimenez-Saez, Jose Carlos

2004-01-01

Low energy boron bombardment of silicon has been simulated at room temperature by molecular dynamics (MD). Tersoff potential T3 was used in the simulation smoothly linked up with the universal potential. The boron-silicon (B-Si) interaction was simulated according to Tersoff potential for SiC but modified to account for the B-Si interaction. The algorithm can distinguish a B from a Si neighbour. Si-c, with (2 x 1) surface reconstruction, was bombarded with boron at 200 and 500 eV. These energies were initially chosen as good representative values of the low energy range. Reliable results require of a reasonable good statistic so that 1000-impact points were chosen uniformly distributed over a representative area of a 2 x 1 surface. The distribution of mean projected range for B is given. All kinds of point defect were looked for in a Si damaged target after bombardment. Energetically stable substitutional and interstitial configurations are presented and the relative appearances of the different types of interstitials, for both Si and B, are given. It is also determined the mean length of the distance to the first neighbours of defects

76 FR 71604 - Kamal Tiwari, M.D.; Pain Management and Surgery Center of Southern Indiana; Decision and Order

Science.gov (United States)

2011-11-18

..., and his principal place of business, the Pain Management and Surgery Center (Respondent PMSC), holder... Certificate of Registration, BP4917413, issued to Respondent Pain Management and Surgery Center of Southern..., M.D. and Pain Management and Surgery Center of Southern Indiana, to renew or modify such...

D1-3: Marshfield Dictionary of Clinical and Translational Science (MD-CTS): An Online Reference for Clinical and Translational Science Terminology

Science.gov (United States)

Finamore, Joe; Ray, William; Kadolph, Chris; Rastegar-Mojarad, Majid; Ye, Zhan; Jacqueline, Bohne; Tachinardi, Umberto; Mendonça, Eneida; Finnegan, Brian; Bartkowiak, Barbara; Weichelt, Bryan; Lin, Simon

2014-01-01

Background/Aims New terms are rapidly appearing in the literature and practice of clinical medicine and translational research. To catalog real-world usage of medical terms, we report the first construction of an online dictionary of clinical and translational medicinal terms, which are computationally generated in near real-time using a big data approach. This project is NIH CTSA-funded and developed by the Marshfield Clinic Research Foundation in conjunction with University of Wisconsin - Madison. Currently titled Marshfield Dictionary of Clinical and Translational Science (MD-CTS), this application is a Google-like word search tool. By entering a term into the search bar, MD-CTS will display that term’s definition, usage examples, contextual terms, related images, and ontological information. A prototype is available for public viewing at http://spellchecker.mfldclin.edu/. Methods We programmatically derived the lexicon for MD-CTS from scholarly communications by parsing through 15,156,745 MEDLINE abstracts and extracting all of the unique words found therein. We then ran this list through several filters in order to remove words that were not relevant for searching, such as common English words and numeric expressions. We then loaded the resulting 1,795,769 terms into SQL tables. Each term is cross-referenced with every occurrence in all abstracts in which it was found. Additional information is aggregated from Wiktionary, Bioportal, and Wikipedia in real-time and displayed on-screen. From this lexicon we created a supplemental dictionary resource (updated quarterly) to be used in Microsoft Office® products. Results We evaluated the utility of MD-CTS by creating a list of 100 words derived from recent clinical and translational medicine publications in the week of July 22, 2013. We then performed comparative searches for each term with Taber’s Cyclopedic Medical Dictionary, Stedman’s Medical Dictionary, Dorland’s Illustrated Medical Dictionary, Medical

Lessons Learned for Online Health Community Moderator Roles: A Mixed-Methods Study of Moderators Resigning From WebMD Communities

Science.gov (United States)

Marmor, Rebecca; Jiang, Xiaoqian

2016-01-01

Background Online health community (OHC) moderators help facilitate conversations and provide information to members. However, the necessity of the moderator in helping members achieve goals by providing the support they need remains unclear, with some prior research suggesting that moderation is unnecessary or even harmful for close-knit OHCs. Similarly, members’ perceptions of moderator roles are underexplored. Starting January of 2013, WebMD moderators stopped working for WebMD communities. This event provided an opportunity for us to study the perceived role of moderators in OHCs. Objective We examine the OHC members’ perception on OHC moderators by studying their reactions toward the departure of moderators in their communities. We also analyzed the relative posting activity on OHCs before and after the departure of moderators from the communities among all members and those who discussed moderators’ departures. Methods We applied a mixed-methods approach to study the posts of all 55 moderated WebMD communities by querying the terms relating to discussions surrounding moderators’ disappearance from the WebMD community. We performed open and axial coding and affinity diagramming to thematically analyze patients’ reactions to the disappeared moderators. The number of posts and poster groups (members and moderators) were analyzed over time to understand posting patterns around moderators’ departure. Results Of 821 posts retrieved under 95 threads, a total of 166 open codes were generated. The codes were then grouped into 2 main themes with 6 total subthemes. First, patients attempted to understand why moderators had left and what could be done to fill the void left by the missing moderators. During these discussions, the posts revealed that patients believed that moderators played critical roles in the communities by making the communities vibrant and healthy, finding solutions, and giving medical information. Some patients felt personally attached

Improved operation in CANDU plants with CAN8 PHT pump seals

International Nuclear Information System (INIS)

Graham, T.; McInnes, D.; Rhodes, D.

1997-01-01

The CAN8 PHT pump seal is currently operating in twenty-one pumps, twelve at Bruce A, seven at Bruce B and in both pumps at Grand Gulf Nuclear Station (GGNS). The CAN8 seal has markedly improved performance over the CAN2 seal previously used at the Bruce stations and the SU seals previously used at GGNS. Details of the performance improvements are discussed. Prior to installation in Bruce B, the CAN8 seal was slightly modified and then demonstrated to be resistant to reverse pressurization failures, since this was a known failure mechanism with the CAN2 seal. Subsequent experience showed that Bruce A was also susceptible to reverse pressure incidents. A review of plant operating procedures at Bruce A showed reverse pressure was likely the initiating factor for several previously unexplained seal disturbances. The reverse pressure failure mechanism is described, as are the improved system operating procedures designed to prevent it. Preventative procedures have now been implemented across Ontario Hydro Nuclear. The ability to track down seal failure mechanisms such as this is greatly enhanced by the improved system monitoring and data retrieval now in place at Bruce A and Bruce B. (author)

Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality

International Nuclear Information System (INIS)

Ling, C. Clifton; Humm, John; Larson, Steven; Amols, Howard; Fuks, Zvi; Leibel, Steven; Koutcher, Jason A.

2000-01-01

Purpose: The goals of this study were to survey and summarize the advances in imaging that have potential applications in radiation oncology, and to explore the concept of integrating physical and biological conformality in multidimensional conformal radiotherapy (MD-CRT). Methods and Materials: The advances in three-dimensional conformal radiotherapy (3D-CRT) have greatly improved the physical conformality of treatment planning and delivery. The development of intensity-modulated radiotherapy (IMRT) has provided the 'dose painting' or 'dose sculpting' ability to further customize the delivered dose distribution. The improved capabilities of nuclear magnetic resonance imaging and spectroscopy, and of positron emission tomography, are beginning to provide physiological and functional information about the tumor and its surroundings. In addition, molecular imaging promises to reveal tumor biology at the genotype and phenotype level. These developments converge to provide significant opportunities for enhancing the success of radiotherapy. Results: The ability of IMRT to deliver nonuniform dose patterns by design brings to fore the question of how to 'dose paint' and 'dose sculpt', leading to the suggestion that 'biological' images may be of assistance. In contrast to the conventional radiological images that primarily provide anatomical information, biological images reveal metabolic, functional, physiological, genotypic, and phenotypic data. Important for radiotherapy, the new and noninvasive imaging methods may yield three-dimensional radiobiological information. Studies are urgently needed to identify genotypes and phenotypes that affect radiosensitivity, and to devise methods to image them noninvasively. Incremental to the concept of gross, clinical, and planning target volumes (GTV, CTV, and PTV), we propose the concept of 'biological target volume' (BTV) and hypothesize that BTV can be derived from biological images and that their use may incrementally improve

Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

Science.gov (United States)

2014-01-01

A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

MTS-MD of Biomolecules Steered with 3D-RISM-KH Mean Solvation Forces Accelerated with Generalized Solvation Force Extrapolation.

Science.gov (United States)

Omelyan, Igor; Kovalenko, Andriy

2015-04-14

We developed a generalized solvation force extrapolation (GSFE) approach to speed up multiple time step molecular dynamics (MTS-MD) of biomolecules steered with mean solvation forces obtained from the 3D-RISM-KH molecular theory of solvation (three-dimensional reference interaction site model with the Kovalenko-Hirata closure). GSFE is based on a set of techniques including the non-Eckart-like transformation of coordinate space separately for each solute atom, extension of the force-coordinate pair basis set followed by selection of the best subset, balancing the normal equations by modified least-squares minimization of deviations, and incremental increase of outer time step in motion integration. Mean solvation forces acting on the biomolecule atoms in conformations at successive inner time steps are extrapolated using a relatively small number of best (closest) solute atomic coordinates and corresponding mean solvation forces obtained at previous outer time steps by converging the 3D-RISM-KH integral equations. The MTS-MD evolution steered with GSFE of 3D-RISM-KH mean solvation forces is efficiently stabilized with our optimized isokinetic Nosé-Hoover chain (OIN) thermostat. We validated the hybrid MTS-MD/OIN/GSFE/3D-RISM-KH integrator on solvated organic and biomolecules of different stiffness and complexity: asphaltene dimer in toluene solvent, hydrated alanine dipeptide, miniprotein 1L2Y, and protein G. The GSFE accuracy and the OIN efficiency allowed us to enlarge outer time steps up to huge values of 1-4 ps while accurately reproducing conformational properties. Quasidynamics steered with 3D-RISM-KH mean solvation forces achieves time scale compression of conformational changes coupled with solvent exchange, resulting in further significant acceleration of protein conformational sampling with respect to real time dynamics. Overall, this provided a 50- to 1000-fold effective speedup of conformational sampling for these systems, compared to conventional MD

Prediction and analysis of the structure of hydrated Mn2+, V2+, Ti3 and Cr3 ions by means of the MD simulation methods

International Nuclear Information System (INIS)

Iglesias, Y.J.

2002-01-01

Classical Molecular dynamics (MD) and hybrid Quantum/Molecular Mechanics-Molecular Dynamics (QM/MM-MD) simulations have been performed to investigate structural properties of Mn(II), V(II), Cr(III) and Ti(III) cations in aqueous solution. The first hydration sphere in QM/MM-MD simulations is treated quantum mechanically, while the rest of the system is described by classical analytical two- and three-body potentials. The results obtained for the first hydration shell from this method are in agreement with experimental data, showing 100 % of 6 fold coordination around the ion in all cases. The results prove that non/additive contributions are mandatory for an accurate description of ion hydration. Within the QM/MM method, the inclusion of a perturbation field describing the remaining system was shown to be an accurate tool for evaluating the first shell structure, and thus to be a good alternative for systems, where the construction of a three-body correction function is difficult or too time-consuming. (author)

Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.

Science.gov (United States)

Tkavc, Rok; Matrosova, Vera Y; Grichenko, Olga E; Gostinčar, Cene; Volpe, Robert P; Klimenkova, Polina; Gaidamakova, Elena K; Zhou, Carol E; Stewart, Benjamin J; Lyman, Mathew G; Malfatti, Stephanie A; Rubinfeld, Bonnee; Courtot, Melanie; Singh, Jatinder; Dalgard, Clifton L; Hamilton, Theron; Frey, Kenneth G; Gunde-Cimerman, Nina; Dugan, Lawrence; Daly, Michael J

2017-01-01

Highly concentrated radionuclide waste produced during the Cold War era is stored at US Department of Energy (DOE) production sites. This radioactive waste was often highly acidic and mixed with heavy metals, and has been leaking into the environment since the 1950s. Because of the danger and expense of cleanup of such radioactive sites by physicochemical processes, in situ bioremediation methods are being developed for cleanup of contaminated ground and groundwater. To date, the most developed microbial treatment proposed for high-level radioactive sites employs the radiation-resistant bacterium Deinococcus radiodurans . However, the use of Deinococcus spp. and other bacteria is limited by their sensitivity to low pH. We report the characterization of 27 diverse environmental yeasts for their resistance to ionizing radiation (chronic and acute), heavy metals, pH minima, temperature maxima and optima, and their ability to form biofilms. Remarkably, many yeasts are extremely resistant to ionizing radiation and heavy metals. They also excrete carboxylic acids and are exceptionally tolerant to low pH. A special focus is placed on Rhodotorula taiwanensis MD1149, which was the most resistant to acid and gamma radiation. MD1149 is capable of growing under 66 Gy/h at pH 2.3 and in the presence of high concentrations of mercury and chromium compounds, and forming biofilms under high-level chronic radiation and low pH. We present the whole genome sequence and annotation of R. taiwanensis strain MD1149, with a comparison to other Rhodotorula species. This survey elevates yeasts to the frontier of biology's most radiation-resistant representatives, presenting a strong rationale for a role of fungi in bioremediation of acidic radioactive waste sites.

Prediction of drug-packaging interactions via molecular dynamics (MD) simulations.

Science.gov (United States)

Feenstra, Peter; Brunsteiner, Michael; Khinast, Johannes

2012-07-15

The interaction between packaging materials and drug products is an important issue for the pharmaceutical industry, since during manufacturing, processing and storage a drug product is continuously exposed to various packaging materials. The experimental investigation of a great variety of different packaging material-drug product combinations in terms of efficacy and safety can be a costly and time-consuming task. In our work we used molecular dynamics (MD) simulations in order to evaluate the applicability of such methods to pre-screening of the packaging material-solute compatibility. The solvation free energy and the free energy of adsorption of diverse solute/solvent/solid systems were estimated. The results of our simulations agree with experimental values previously published in the literature, which indicates that the methods in question can be used to semi-quantitatively reproduce the solid-liquid interactions of the investigated systems. Copyright © 2012 Elsevier B.V. All rights reserved.

Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis

Science.gov (United States)

Park, In-Hee; Venable, John D.; Steckler, Caitlin; Cellitti, Susan E.; Lesley, Scott A.; Spraggon, Glen; Brock, Ansgar

2015-01-01

Hydrogen exchange (HX) studies have provided critical insight into our understanding of protein folding, structure and dynamics. More recently, Hydrogen Exchange Mass Spectrometry (HX-MS) has become a widely applicable tool for HX studies. The interpretation of the wealth of data generated by HX-MS experiments as well as other HX methods would greatly benefit from the availability of exchange predictions derived from structures or models for comparison with experiment. Most reported computational HX modeling studies have employed solvent-accessible-surface-area based metrics in attempts to interpret HX data on the basis of structures or models. In this study, a computational HX-MS prediction method based on classification of the amide hydrogen bonding modes mimicking the local unfolding model is demonstrated. Analysis of the NH bonding configurations from Molecular Dynamics (MD) simulation snapshots is used to determine partitioning over bonded and non-bonded NH states and is directly mapped into a protection factor (PF) using a logistics growth function. Predicted PFs are then used for calculating deuteration values of peptides and compared with experimental data. Hydrogen exchange MS data for Fatty acid synthase thioesterase (FAS-TE) collected for a range of pHs and temperatures was used for detailed evaluation of the approach. High correlation between prediction and experiment for observable fragment peptides is observed in the FAS-TE and additional benchmarking systems that included various apo/holo proteins for which literature data were available. In addition, it is shown that HX modeling can improve experimental resolution through decomposition of in-exchange curves into rate classes, which correlate with prediction from MD. Successful rate class decompositions provide further evidence that the presented approach captures the underlying physical processes correctly at the single residue level. This assessment is further strengthened in a comparison of

Serpins in fruit and vegetative tissues of apple (Malus domestica): expression of four serpins with distinct reactive centres and characterisation of a major inhibitory seed form, MdZ1b

DEFF Research Database (Denmark)

Hejgaard, Jørn; Laing, W.A.; Marttila, S.

2005-01-01

in a wide variety of tissues, including developing and mature fruits, seeds and vegetative buds as well as developing, mature and senescing leaves. Analysis of 46 sequences, most full-length, identified serpins with four distinct reactive centres belonging to two subfamilies (MdZ1 and MdZ2) with similar...

LaSalle D. Leffall Jr., M.D. The Man and the Mission.

Science.gov (United States)

Cornwell, Edward E

2018-06-01

On March 19-20, 2017; Howard University hosted a Festschrift inspired by Dr. Leffall's writings (Fig. 1). The celebrants highlighted the broad spectrum of Dr. Leffall's contributions in mentorship, leadership in American Surgery, breast cancer, endocrine cancer, pancreatic cancer, and familial polyposis coli. Perhaps most inspirational was the awe inspiring consistency the presenters demonstrated in describing the personal characteristics Dr. Leffall brings to his academic discourse: his encyclopedic knowledge and recall, his charm, eloquence, humility, and his total dedication to the patient, his students, and trainees. We are greatly indebted to Kirby Bland M.D., FACS for offering the pages of The American Journal of Surgery to illuminate this celebration. Copyright © 2017. Published by Elsevier Inc.

MD-11 PCA - Closeup view of aircraft on ramp

Science.gov (United States)

1995-01-01

This McDonnell Douglas MD-11 has taxied to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

Millennial-Scale Planktic Foraminifer Faunal Variability in the East China Sea during the Past 40000 Years (IMAGES MD012404 from the Okinawa Trough

Directory of Open Access Journals (Sweden)

Yuan-Pin Chang

2008-01-01

Full Text Available High resolution planktic foraminifer fauna assemblage data are used to reconstruct the millennial-scale sea surface temperature (SST variability of the past 40000 years at an IMAGES core site (MD012404 in the Okinawa Trough in the East China Sea (ECS. The fauna assemblages in core MD012404 are dominated by five species - Globigerinoides ruber, Globigerina bulloides, Neogloboquadrina dutertrei, Pulleniatina obliquiloculata, and Globigerinita glutinata, which account for > 70% in relative abundance. Our Q-mode factor analysis decomposed the fauna abundance data into three factors, which indicate cold water mass, warm water mass, and possibly coastal water flow with low salinity in the ECS. The MD012404 fauna data show abrupt changes at ~16 kya, suggesting a return to a warmer climate or warm water intrusion of the Kuroshio into the Okinawa Trough since the Last Glacial Maximum (LGM. SST estimates based on the fauna assemblages of planktic foraminifers indicate a LGM cooling of 1 - 2°C. Amaximum cooling by 3 - 4°C is observed in episodic, millennial-scale events in the glacial stages of the record. The SST record displays variability that closely tracks the structure of oxygen isotopes of stalagmites from Hulu Cave and ice cores from GISP 2 Dansgaard/Oeschger cycles and Heinrich events. Low salinity in the ECS is inferred based on MD012404 fauna SST and planktic foraminifer oxygen isotope records for the cold millennial-scale intervals, pointing to the Intertropical Convergence Zone (ITCZ and/or East Asian monsoon as important factors driving SST and salinity in the subtropical western Pacific, both on orbital and suborbital time scales.

High-Resolution Forest Carbon Monitoring and Modeling: Continued Prototype Development and Deployment Across The Tri-state Area (MD, PA, DE), USA

Science.gov (United States)

Hurtt, G. C.; Birdsey, R.; Campbell, E.; Dolan, K. A.; Dubayah, R.; Escobar, V. M.; Finley, A. O.; Flanagan, S.; Huang, W.; Johnson, K.; Lister, A.; ONeil-Dunne, J.; Sepulveda Carlo, E.; Zhao, M.

2017-12-01

Local, national and international programs have increasing need for precise and accurate estimates of forest carbon and structure to support greenhouse gas reduction plans, climate initiatives, and other international climate treaty frameworks. In 2010 Congress directed NASA to initiate research towards the development of Carbon Monitoring Systems (CMS). In response, our team has worked to develop a robust, replicable framework to produce maps of high-resolution carbon stocks and future carbon sequestration potential. High-resolution (30m) maps of carbon stocks and uncertainty were produced by linking national 1m-resolution imagery and existing wall-to-wall airborne lidar to spatially explicit in-situ field observations such as the USFS Forest Inventory and Analysis (FIA) network. These same data, characterizing forest extent and vertical structure, were used to drive a prognostic ecosystem model to predict carbon fluxes and carbon sequestration potential at unprecedented spatial resolution and scale (90m), more than 100,000 times the spatial resolution of standard global models. Through project development, the domain of this research has expanded from two counties in MD (2,181 km2), to the entire state (32,133 km2), to the tri-state region of MD, PA, and DE (157,868 km2), covering forests in four major USDA ecological providences (Eastern Broadleaf, Northeastern Mixed, Outer Coastal Plain, and Central Appalachian). Across the region, we estimate 694 Tg C (14 DE, 113 MD, 567 PA) in above ground biomass, and estimate a carbon sequestration potential more than twice that amount. Empirical biomass products enhance existing approaches though high resolution accounting for trees outside traditional forest maps. Modeling products move beyond traditional MRV, and map future afforestation and reforestation potential for carbon at local actionable spatial scales. These products are relevant to multiple stakeholder needs in the region as discussed through the Tri

Building and Deploying Remotely Operated Vehicles in the First-Year Experience

Science.gov (United States)

O'Brien-Gayes, A.; Fuss, K.; Gayes, P.

2007-12-01

Coastal Carolina University has committed to improving student retention and success in Mathematics and Science through a pilot program to engage first-year students in an applied and investigative project as part of the University's First-Year Experience (FYE). During the fall 2007 semester, five pilot sections of FYE classes, consisting of students from the College of Natural and Applied Sciences are building and deploying Remotely Operated Vehicles (ROVs). These ROV-based classes are designed to: accelerate exploration of the broad fields of science and mathematics; enlist interest in technology by engaging students in a multi-stepped, interdisciplinary problem solving experience; explore science and mathematical concepts; institute experiential learning; and build a culture of active learners to benefit student success across traditional departmental boundaries. Teams of three students (forty teams total) will build, based on the MIT Sea Perch design, and test ROVs in addition to collecting data with their ROVs. Various accessories attached to the vehicles for data collection will include temperature and light sensors, plankton nets and underwater cameras. The first-year students will then analyze the data, and the results will be documented as part of their capstone projects. Additionally, two launch days will take place on two campus ponds. Local middle and high school teachers and their students will be invited to observe this event. The teams of students with the most capable and successful ROVs will participate in a workshop held in November 2007 for regional elementary, middle and high school teachers. These students will give a presentation on the building of the ROVs and also provide a hands-on demonstration for the workshop participants. These activities will ensure an incorporation of service learning into the first semester of the freshmen experience. The desired outcomes of the ROV-based FYE classes are: increased retention at the postsecondary

What's new in management discussion and analysis (MD and A)

International Nuclear Information System (INIS)

Bradley, N.M.

1998-01-01

Disclosure obligations under the management and discussion analysis (MD and A) with respect to uncertainties regarding the millennium bug were discussed from a legal perspective. The year 2000 problem stems from the use of only two digits to represent the year in the date field throughout most computer programs, rendering computers unable to differentiate between the year 1900 and the year 2000. Companies should be aware that specific requirements have been imposed by securities regulators in Canada and the United States over and above the general continuous disclosure requirements. These new requirements are designed to assist companies to minimize their liability, and at the same time to motivate them to make progress in their Y2K efforts. Details of CSA Staff Notice 41-301 and 51-302 entitled 'The year 2000 challenge - Disclosure issues' and similar U.S. Securities and Stock Exchange requirements are reviewed. Specific examples of Y2K disclosure issues in the Canadian petroleum industry are described. 23 refs

Transport and characterization of ambient biological aerosol near Laurel, MD

Science.gov (United States)

Santarpia, J. L.; Cunningham, D.; Gilberry, J.; Kim, S.; Smith, E. E.; Ratnesar-Shumate, S.; Quizon, J.

2010-09-01

Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

An Insight into the Environmental Effects of the Pocket of the Active Site of the Enzyme. Ab initio ONIOM-Molecular Dynamics (MD) Study on Cytosine Deaminase

International Nuclear Information System (INIS)

Matsubara, Toshiaki; Dupuis, Michel; Aida, Misako

2008-01-01

We applied the ONIOM-molecular dynamics (MD) method to cytosine deaminase to examine the environmental effects of the amino acid residues in the pocket of the active site on the substrate taking account of their thermal motion. The ab initio ONIOM-MD simulations show that the substrate uracil is strongly perturbed by the amino acid residue Ile33, which sandwiches the uracil with His62, through the steric contact due to the thermal motion. As a result, the magnitude of the thermal oscillation of the potential energy and structure of the substrate uracil significantly increases. TM and MA were partly supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.MD was supported by the Division of Chemical Sciences, Office of Basic Energy Sciences, and by the Office of Biological and Environmental Research of the U.S. Department of Energy DOE. Battelle operates Pacific Northwest National Laboratory for DOE

Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149

Directory of Open Access Journals (Sweden)

Rok Tkavc

2018-01-01

Full Text Available Highly concentrated radionuclide waste produced during the Cold War era is stored at US Department of Energy (DOE production sites. This radioactive waste was often highly acidic and mixed with heavy metals, and has been leaking into the environment since the 1950s. Because of the danger and expense of cleanup of such radioactive sites by physicochemical processes, in situ bioremediation methods are being developed for cleanup of contaminated ground and groundwater. To date, the most developed microbial treatment proposed for high-level radioactive sites employs the radiation-resistant bacterium Deinococcus radiodurans. However, the use of Deinococcus spp. and other bacteria is limited by their sensitivity to low pH. We report the characterization of 27 diverse environmental yeasts for their resistance to ionizing radiation (chronic and acute, heavy metals, pH minima, temperature maxima and optima, and their ability to form biofilms. Remarkably, many yeasts are extremely resistant to ionizing radiation and heavy metals. They also excrete carboxylic acids and are exceptionally tolerant to low pH. A special focus is placed on Rhodotorula taiwanensis MD1149, which was the most resistant to acid and gamma radiation. MD1149 is capable of growing under 66 Gy/h at pH 2.3 and in the presence of high concentrations of mercury and chromium compounds, and forming biofilms under high-level chronic radiation and low pH. We present the whole genome sequence and annotation of R. taiwanensis strain MD1149, with a comparison to other Rhodotorula species. This survey elevates yeasts to the frontier of biology's most radiation-resistant representatives, presenting a strong rationale for a role of fungi in bioremediation of acidic radioactive waste sites.

Differential host response to LPS variants in amniochorion and the TLR4/MD-2 system in Macaca nemestrina

Science.gov (United States)

Chang, Justine; Jain, Sumita; Carl, David J.; Paolella, Louis; Darveau, Richard P.; Gravett, Michael G.; Waldorf, Kristina M. Adams

2010-01-01

OBJECTIVES Microbial-specific factors are likely critical in determining whether bacteria trigger preterm labor. Structural variations in lipopolysaccharide (LPS), a component of gram-negative bacteria, can determine whether LPS has an inflammatory (agonist) or anti-inflammatory (antagonist) effect through Toll-like receptor 4 (TLR4). Our objective was to determine whether amniochorion can discriminate between LPS variants in a nonhuman primate model. We also cloned Macaca nemestrina TLR4 and MD-2 and compared this complex functionally to the human homologue to establish whether nonhuman primates could be used to study TLR4 signaling in preterm birth. STUDY DESIGN Amniochorion explants from M. nemestrina were stimulated with a panel of LPS variants for 24 hours. Supernatants were analyzed for IL-1β, TNF-α, IL-6, IL-8 and prostaglandins E2 and F2α. Tissue expression of TLR1, 2, 4, 6, MyD88 and NF-kB was studied by RT-PCR. M. nemestrina TLR4 and MD2 genes were cloned and compared with their human counterparts in a recombinant TLR4 signaling system to determine LPS sensitivity. RESULTS LPS variants differentially stimulated cytokines and prostaglandins, which was not related to transcriptional changes of TLR4 or other TLRs. Nearly all elements of LPS binding and TLR4 leucine-rich repeats were conserved between humans and M. nemestrina. TLR4/MD-2 signaling complexes from both species were equally sensitive to LPS variants. CONCLUSIONS LPS variants elicit a hierarchical inflammatory response within amniochorion that may contribute to preterm birth. LPS sensitivity is similar between M. nemestrina and humans, validating M. nemestrina as an appropriate model to study TLR4 signaling in preterm birth. PMID:20619890

A Study to Develop a Methodology to Enable Direct Cost UCA (Uniform Chart of Accounts) Data to Be Expressed in Terms of Cost per Admission for Specific Diagnosis Related Groups

Science.gov (United States)

1985-07-01

Medical Center, Tuskegee, Alabama, interview conducted during visit to his office, 11 April 1985. 5. Turner, Jeff R , "The Inadequacies of the Medical... bedridden soldier, not only because of his adverse effect on the mission of the unit, but also because of the unit’s inability to provide proper assistance...Fye, S. P.; Bigelow, R . E.; Haddock, W. D.; and Ward, R . F. "The Relationship Between Inpatient Service Cost and Case- Complexity at Wilford Hall

Temperature dependence of gafchromic MD-55 dosimeter

International Nuclear Information System (INIS)

Klassen, Norman V.; Zwan, Len van der; Cygler, Joanna

1997-01-01

Objective: Gafchromic MD-55 is a fairly new, thin film dosimeter that develops a blue color (λ max = 676 nm) when irradiated with ionizing radiation. The increase in absorbance is nearly proportional to the absorbed dose. MD-55 can be used for high precision dosimetry if care is taken to assure reproducible film orientation in the spectrophotometer as well as temperature control during both irradiation and reading. In order to achieve the maximum sensitivity of this dosimeter the readings of the optical density should be taken at λ max . It was reported for another type of Gafchromic film (DM-1260), that both λ max and ε max decrease with an increase in the temperature of the spectrophotometer. The purpose of this study was to characterize the reading temperature dependence of the new type of Gafchromic film available on the market and to find optimal conditions for using it for high precision dosimetry. Materials and Methods: Irradiations were carried out using 60 Co gamma rays from an Eldorado irradiator. The dosimeters were sandwiched in a lucite phantom with 4.4 mm build-up and irradiated in the center of a 10 cm x 10 cm field at 1 meter from the source. The temperature during irradiations was 22 deg. C. The dose rate was about 0.68 Gy/min. Measurements of optical density were made using a Cary 210 spectrophotometer. A bandpass of 3.5 nm was used. The temperature of the baseplate of the sample holder was regulated to +/-0.05 deg. C and measured by a probe lying on the baseplate. In all cases, values of OD were only recorded after they had come to a constant value, which was reached within 5 minutes of inserting the dosimeter into the sample chamber of the spectrophotometer. Results: The temperature dependence of the OD at 676 nm was measured in 2 studies using 6 dosimeters that had received 0, 1.0, 3.5, 6.2, 14.5 Gy. Readings were taken at 7 temperatures between 18.8 and 28.1 deg. C. By returning to the initial temperature several hours later, it was found

Program planning for large-scale control system upgrades

International Nuclear Information System (INIS)

Madani, M.; Giajnorio, J.; Richard, T.; Ho, D.; Volk, W.; Ertel, A.

2011-01-01

Bruce Power has been planning to replace the Bruce A Fuel Handling (FH) computer systems including the Controller and Protective computers for many years. This is a complex project, requiring an extended FH outage. To minimize operational disruption and fully identify associated project risks, Bruce Power is executing the project in phases starting with the Protective Computer replacement. GEH-C is collaborating with Bruce Power in a Preliminary Engineering (PE) phase to generate a project plan including specifications, budgetary cost, schedule, risks for the Protective computer replacement project. To assist Bruce Power in its evaluation, GEH-C's is using 6-Sigma methodologies to identify and rank Critical to Quality (CTQ) requirements in collaboration with Bruce Power Maintenance, Operations, Plant Design and FH Engineering teams. PE phase established the project scope, hardware and software specifications, material requirements and finally concluded with a recommended hardware platform and approved controls architecture.

A conceptual demonstration of freeze desalination-membrane distillation (FD-MD) hybrid desalination process utilizing liquefied natural gas (LNG) cold energy.

Science.gov (United States)

Wang, Peng; Chung, Tai-Shung

2012-09-01

The severe global water scarcity and record-high fossil oil price have greatly stimulated the research interests on new desalination technologies which can be driven by renewable energy or waste energy. In this study, a hybrid desalination process comprising freeze desalination and membrane distillation (FD-MD) processes was developed and explored in an attempt to utilize the waste cold energy released from re-gasification of liquefied natural gas (LNG). The concept of this technology was demonstrated using indirect-contact freeze desalination (ICFD) and direct-contact membrane distillation (DCMD) configurations. By optimizing the ICFD operation parameters, namely, the usage of nucleate seeds, operation duration and feed concentration, high quality drinkable water with a low salinity ∼0.144 g/L was produced in the ICFD process. At the same time, using the optimized hollow fiber module length and packing density in the DCMD process, ultra pure water with a low salinity of 0.062 g/L was attained at a condition of high energy efficiency (EE). Overall, by combining FD and MD processes and adopting the optimized operation parameters, the hybrid FD-MD system has been successfully demonstrated. A high total water recovery of 71.5% was achieved, and the water quality obtained met the standard for drinkable water. In addition, with results from specific energy calculation, it was proven that the hybrid process is an energy-saving process and utilization of LNG cold energy could greatly reduce the total energy consumption. Copyright © 2012 Elsevier Ltd. All rights reserved.

Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

OpenAIRE

Karim Shahbazi; Mohammad Eshghi; Reza Faghih Mirzaee

2017-01-01

In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function units and two data buses. It has also two types of 32-bit instruction formats for executing Memory Reference (M.R.), Register Reference (R.R.), and Input/Output Reference (I/O R.) instructions. The maximum achieved frequency is 166.916 MHz. T...

Aircraft Accident Report. Runway Overrun During Landing American Airlines Flight 1420 McDonnell Douglas MD-82, N215AA Little Rock, Arkansas

National Research Council Canada - National Science Library

1999-01-01

This report explains the accident involving American Airlines flight 1420, a McDonnell Douglas MD-82, which crashed after it overran the end of runway 4R during landing at Little Rock National Airport...

77 FR 65184 - Proposed Information Collection; Comment Request

Science.gov (United States)

2012-10-25

... sent to: Corporation for National and Community Service, Attn.: Bruce Kellogg, 3809C, 1201 New York... through Friday, except Federal holidays. (3) By fax to: (202) 606-3492, Attn.: Bruce Kellogg (4... FURTHER INFORMATION CONTACT: Bruce Kellogg, (202) 606-6954, or by email at [email protected

77 FR 65183 - Proposed Information Collection; Comment Request

Science.gov (United States)

2012-10-25

...: Corporation for National and Community Service, Attn.: Bruce Kellogg, 3809C, 1201 New York Avenue NW..., except Federal holidays. (3) By fax to: (202) 606-3492, Attn.: Bruce Kellogg. (4) Electronically through... INFORMATION CONTACT: Bruce Kellogg, (202) 606-6954, or by email at [email protected] . SUPPLEMENTARY...

76 FR 25673 - Proposed Information Collection; Comment Request

Science.gov (United States)

2011-05-05

...: Corporation for National and Community Service, National Service Trust; Attention Bruce Kellogg; 1201 New York... Friday, except Federal holidays. (3) By fax to: (202) 606-3492, Attention: Bruce Kellogg. (4..., Monday through Friday. FOR FURTHER INFORMATION CONTACT: Bruce Kellogg, (202) 606-6954, or by e-mail at...

76 FR 25672 - Proposed Information Collection; Comment Request

Science.gov (United States)

2011-05-05

... Community Service, National Service Trust; Attention Bruce Kellogg; 1201 New York Avenue, NW., Washington... holidays. (3) By fax to: (202) 606-3492, Attention: Bruce Kellogg. (4) Electronically through the... Friday. FOR FURTHER INFORMATION CONTACT: Bruce Kellogg, (202) 606-6954, or by e-mail at [email protected