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Sample records for brothers full brothers

  1. Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers

    DEFF Research Database (Denmark)

    Jensen, Morten Søndergaard; Toft, Gunnar; Thulstrup, Ane Marie

    2010-01-01

    to December 31, 2004. Classic twin method and computerized square dance design. SETTING: Hospitals and outpatient clinics. PATIENT(S): Six groups of boy pairs: boys with no relation, paternal half-brothers, maternal half-brothers, full brothers, dizygotic twin brothers, and monozygotic twin brothers...

  2. My Brother Warren.

    Science.gov (United States)

    Forbes, Eric

    1987-01-01

    The younger brother of a hyperactive, severely learning-disabled 21-year-old recounts his feelings regarding lack of parental attention, jealousy toward his older brother, embarrassment, and finally empathy for his older brother. (CB)

  3. Brothers in Arms:

    DEFF Research Database (Denmark)

    Vincent, Stéphanie; Bingley, Paul; Lundborg, Petter

    Family members tend to have similar labor market outcomes, but measuring the contribution of behavioral spillovers is difficult. To identify spillovers between brothers, we exploit Denmark’s largest random assignment – of young men to 8 months of military service – where service status of brothers...

  4. Bilateral breast in brothers - abreast

    Directory of Open Access Journals (Sweden)

    Altamash Mohammed Yusuf Shaikh

    2013-01-01

    Full Text Available Gynecomastia is a common occurrence in pubertal age group, and is physiological in up to 65 percent of cases. When occurs in the family it should be investigated in order not to miss on a treatable etiology. Two brothers within the same family, presenting with bilateral gynecomastia of different causes and requiring different treatment are presented.

  5. 75 FR 71458 - Warner Brothers Entertainment, Inc., Warner Brothers Theatrical Enterprises, Including Workers of...

    Science.gov (United States)

    2010-11-23

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,775] Warner Brothers Entertainment, Inc., Warner Brothers Theatrical Enterprises, Including Workers of the Following Operating Entities: Burbank Television Enterprises LLC, Warner Brothers Consumer Products, Inc., Warner Brothers...

  6. "I Loved My Brother Infinitely…"

    Directory of Open Access Journals (Sweden)

    Pavel Fokin

    2014-12-01

    Full Text Available Abstract Literary heritage of Mikhail Mikhailovich Dostoevsky(1820-1864 is not very abundant and appeals to experts only. His personality is of much more importance for national and world culture. He was a friend and soul mate of his genius brother (almost coeval. Their relations were an essential element of the biography and spiritual identity of Fyodor Dostoevsky. Mikhail was the first and for many years the only interlocutor of F.M. Dostoevsky. His role as an addressee in Fyodor Dostoevsky’s letters cannot be underestimated either. Fyodor Dostoevsky regarded his brother not only as a friend but as a business partner too. Their most successful joint enterprise was publishing of the magazine “Time” (“Vremya” (1861–1863, whose initiator and owner became Mikhail Dostoevsky. After Мikhail’s death Fyodor took charge of his family that had both direct and indirect impact on his own lifestyle. The year 2014 was the 150th anniversary of Mikhail Dostoevsky’s death. In this regard, the State Literature Museum organized an exposition titled “I loved my brother infinitely...” in the F.M. Dostoevsky Museum-Apartment. It was the first exposition dedicated to the personality of Mikhail Dostoevsky and his literary heritage. A lot of exhibit items had never been exposed before.

  7. Joyce Brothers (1927-2013).

    Science.gov (United States)

    Farley, Frank

    2014-01-01

    Joyce Brothers died May 13, 2013, at age 85, in Fort Lee, New Jersey. She was born in Brooklyn, New York, on October 20, 1927. To the public, Joyce Brothers was the best known psychologist of her time. Brothers's influence on the media, and psychology, was considerable and varied. She became the public face of psychology. As her ascendency as a media psychologist progressed, she reinforced the ideas that a PhD psychologist is called "Doctor"; that a woman can create a career in the field and also raise a family; that there are psychological insights about human behavior that everyone can understand; and that psychologists are not always wearing laboratory coats or talking to people who lie on a couch, but can be lively, engaging, understandable, fun, and down-to-earth people. One might speculate that Joyce Brothers brought a lot of young women into careers in psychology. Brothers created an amazing career which she pursued with style and grace. Stepping outside of a traditional psychological career sometimes drew fire from the profession, in line with frequent criticism of popularizers in psychology and other fields. 2014 APA, all rights reserved

  8. "I Loved My Brother Infinitely…"

    OpenAIRE

    Pavel Fokin

    2014-01-01

    Abstract Literary heritage of Mikhail Mikhailovich Dostoevsky(1820-1864) is not very abundant and appeals to experts only. His personality is of much more importance for national and world culture. He was a friend and soul mate of his genius brother (almost coeval). Their relations were an essential element of the biography and spiritual identity of Fyodor Dostoevsky. Mikhail was the first and for many years the only interlocutor of F.M. Dostoevsky. His role as an addressee in Fyodor Dosto...

  9. Scott Brothers Windows and Doors Information Sheet

    Science.gov (United States)

    Scott Brothers Windows and Doors (the Company) is located in Bridgeville, Pennsylvania. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Pittsburgh, Pennsylvania.

  10. My Brother the Mexican

    Directory of Open Access Journals (Sweden)

    K. Angelique Dwyer

    2017-10-01

    Full Text Available El “Piti” le decían, I never knew why. We lived just outside “El Barrio,” at least that’s what they called it, ‘cause it took too long to say “Tlachichilco del Carmen.” Nobody called it that, but my mom. She would make us go to El Barrio a vender “panquecitos.” Two little gringüitos selling cupcakes en la plaza. ...

  11. Nature vs. nurture: two brothers with schizophrenia.

    Science.gov (United States)

    Keltner, N L; James, C A; Darling, R J; Findley, L S; Oliver, K

    2001-01-01

    The nature vs. nurture argument as it pertains to two brothers. To explore the synergistic effects of heritability and environment in the cases of two brothers with schizophrenia. Review of the literature and the authors' clinical experience. The nature vs. nurture dichotomy may not be as relevant as looking at the interaction between these two forces.

  12. 78 FR 76969 - Wright Brothers Day, 2013

    Science.gov (United States)

    2013-12-19

    ... boundaries of human imagination and paving the way for over a century of innovation. On Wright Brothers Day... Top, we are raising standards and making STEM education a priority. Last year, we announced plans to...

  13. Cerebrotendinous xanthomatosis: report of two Brazilian brothers.

    NARCIS (Netherlands)

    Lange, M.C.; Zetola, V.F.; Teive, H.; Scola, R.H.; Trentin, A.P.; Zavala, J.A.; Pereira, E.R.; Raskin, S.; Werneck, L.C.; Sistermans, E.A.

    2004-01-01

    Cerebrotendinous xanthomatosis is a treatable rare autossomal recessive disease characterized by lipid storage secondary to a sterol 27-hydroxylase deficiency in the formation of cholic and chenodeoxycholic acids. We describe two Brazilian brothers with cognitive impairement and chronic diarrhea.

  14. Simple bone cysts of two brothers

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2008-09-15

    17-year-old and 14-year-old brothers were referred for evaluation of the cystic lesions on the mandibular anterior area with no symptoms. Neither their mother nor the brothers could recall any past trauma to those areas. Panoramic and intraoral radiographs revealed moderately defined cystic lesions on their mandibular anterior areas. Biopsies on both lesions revealed simple bone cysts. Hereditary cause or familial history of simple bone cysts could not be found in literature review. This case may have been a coincidence. However, further investigation is needed to find the cause of simple bone cysts occurring in patients those are closely related.

  15. Simple bone cysts of two brothers

    International Nuclear Information System (INIS)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik

    2008-01-01

    17-year-old and 14-year-old brothers were referred for evaluation of the cystic lesions on the mandibular anterior area with no symptoms. Neither their mother nor the brothers could recall any past trauma to those areas. Panoramic and intraoral radiographs revealed moderately defined cystic lesions on their mandibular anterior areas. Biopsies on both lesions revealed simple bone cysts. Hereditary cause or familial history of simple bone cysts could not be found in literature review. This case may have been a coincidence. However, further investigation is needed to find the cause of simple bone cysts occurring in patients those are closely related.

  16. The Wright Brothers and their First Flight

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 12. The Wright Brothers and their First Flight. O N Ramesh. Article-in-a-Box Volume 8 Issue 12 December 2003 pp 3-4. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/008/12/0003-0004 ...

  17. The Wright Brothers and their First Flight

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 12. The Wright Brothers and their First Flight. O N Ramesh. Article-in-a-Box Volume 8 Issue 12 December 2003 pp 3-4. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/008/12/0003-0004 ...

  18. Drs. Smith Brothers: dental surgeons of Calcutta.

    Science.gov (United States)

    Sanjeev, Kumar

    2014-01-01

    During the British raj, India attracted dental practitioners from all over the world who set up practices in the Presidency towns of Calcutta, Bombay, Madras and Bangalore. Lured by the abundant opportunity to make good money, these mercenary but courageous dentists counted Viceroys, Indian royalty and political leaders amongst their clients. Some, like the famous American Smith Brothers of Calcutta, were sought after even by the rulers of neighboring countries. Dr. Mark Smith's hazardous visit to the Amir of Afghanistan made worldwide headlines more than 100 years ago for the fabulous fee he was paid for the dental treatment. This paper briefly describes the exploits and experiences of the Smith brothers while in India.

  19. Five Martyr Brothers. First Polish hermits and their worship

    Directory of Open Access Journals (Sweden)

    Kinga Blaschke

    2016-12-01

    Full Text Available Brothers Benedict and John, students of Romuald, came to Poland at the invitation of Otto III to convert pagans. Soon the Italian hermits were joined by Polish brothers Isaac and Matthew, who helped them in learning the Slavic language. The hermits, as well as Christinus, well killed in 1003 by thugs who wanted to steal money given by Duke Boleslav to an expedition to Rome, which was aimed at obtaining papal consent for conducting missionary work. Although the hermits died as victims of a robbery, killed by fellow Christians, the pope canonized them as martyrs. Their lives are relatively well-documented: the earliest and the most credible story of the five brothers by Bruno of Querfurt was written as early as five years after their death, although remained unknown until 1883. Another early account is the life of St. Romuald by Piotr Damiani of 1041. The martyrs have been also associated with yet another mysterious work – a gravestone unearthed in 1959 at the external wall of the north Roman apse of the Gniezno Cathedral, considered by most researchers the oldest epigraphic item on the Polish soil. However, the identification of the warriors mentioned in the inscription with 11th century martyrs raises many doubts. The article discusses the above matters, as well as the subject of the development of the worship of the martyr brothers.

  20. Partial DAZ deletions in a family with five infertile brothers

    NARCIS (Netherlands)

    Gianotten, Judith; Hoffer, Mariëtte J. V.; de Vries, Jan W. A.; Leschot, Nico J.; Gerris, Jan; van der Veen, Fulco

    2003-01-01

    Objective: To study the genetic cause of infertility in a family with five infertile brothers. Design: Case report. Setting: Center for reproductive medicine at a university medical center. Patient(s): Five brothers presenting with primary infertility due to severely impaired spermatogenesis; also,

  1. Homosexuality in men and number of older brothers.

    Science.gov (United States)

    Blanchard, R; Bogaert, A F

    1996-01-01

    This study investigated whether homosexual men have a higher mean birth order than heterosexual men primarily because they have more older brothers or because they have more older siblings of both sexes. For the main analyses, 302 heterosexual men were individually matched on year of birth with an equal number of heterosexual men. Each completed a self-administered, anonymous questionnaire concerning family background and other biodemographic information. Logistic regression analysis showed that homosexuality was positively correlated with the proband's number of older brothers but not with older sisters, younger brothers, younger sisters, or parental age at the time of the proband's birth. Each additional older brother increased the odds of homosexuality by 33%. These results restrict the range of possible theories of the birth order phenomenon to those that can explain not only why older brothers increase the probability of homosexuality in later-born males but also why older sisters neither enhance this effect nor counteract it.

  2. Lecciones regulatorias de la quiebra de Lehman Brothers

    Directory of Open Access Journals (Sweden)

    William Black

    2010-09-01

    Full Text Available La quiebra de Lehman Brothers el 15 de septiembre de 2008 marcó un parteaguas en la actual crisis financiera/económica mundial. La decisión de las autoridades estadounidenses de no rescatar el banco ha sido objeto a un gran debate público y académico, pero casi siempre carente de una discusión a profundidad sobre el comportamiento del banco. William Black, un exregulador bancario reconocido por detectar los mayores fraudes durante la crisis bancaria de los Savings & Loan en los años ochenta en los Estados Unidos y uno de los criminólogo financiero más activos en la esfera pública estadounidense, ofrece al lector una visión de los negocios turbios de Lehman Brothers que le llevaron a su colapso. Con el respaldo de documentación pública, Black describe y analiza como Lehman Brothers actuaba como un “vector de fraude”, creando y recreando un ambiente criminal en el sector financiero que castiga al comportamiento honesto y premia el crimen financiero. Ese tema, central al entendimiento de la crisis, a la vez poco reconocido, se expone con la maestría de quien es uno de sus mejores conocedores.

  3. Neurological and architectural sinuosities: the Niemeyer brothers.

    Science.gov (United States)

    Cavalcanti, Daniel D; Guasti, José Antonio D; Preul, Mark C

    2010-11-01

    In a family of 7 siblings in Rio de Janeiro, Brazil, 2 of the most remarkable national personalities decided to follow different fields at the beginning of the 20th century. Their life's work would, however, intersect in at least 2 respects: the quest for innovation and a passion for sinuosity. The achievements of Paulo and Oscar Niemeyer are landmarks in the history of neurosurgery and architecture in Brazil. Among his many innovations in neurosurgery, Paulo Niemeyer first described the transventricular amygdalohippocampectomy in 1957 and introduced the operating microscope to neurosurgery in Brazil in 1971. His brother Oscar became a world-renowned representative of the modern architecture movement, sculpting graceful curves from concrete.

  4. Brother Peter of Jesus at Purgatory: rewrites of a historiographyc passage

    Directory of Open Access Journals (Sweden)

    Joan Mahiques Climent

    2016-12-01

    Full Text Available The second volume of the Reforma de los descalzos (Madrid, 1655 of Brother Francis of St. Mary relates that Brother Peter of Jesus, while dying in Bellpuig because of the plague, appeared to a companion in Lleida to say he was in Purgatory. From different printed works and engravings published from 1681 to 1724, we study the relationship between texts and images representing this episode. We also edit two versions written by Brother John of St. Joseph (1642-1718, whose autographs are preserved in mss. 990 and 991 of the University of Barcelona Library.

  5. The Lehman Brothers effect and bankruptcy cascades

    Science.gov (United States)

    Sieczka, P.; Sornette, D.; Holyst, J. A.

    2011-08-01

    Inspired by the bankruptcy of Lehman Brothers and its consequences on the global financial system, we develop a simple model in which the Lehman default event is quantified as having an almost immediate effect in worsening the credit worthiness of all financial institutions in the economic network. In our stylized description, all properties of a given firm are captured by its effective credit rating, which follows a simple dynamics of co-evolution with the credit ratings of the other firms in our economic network. The dynamics resembles the evolution of Potts spin-glass with external global field corresponding to a panic effect in the economy. The existence of a global phase transition, between paramagnetic and ferromagnetic phases, explains the large susceptibility of the system to negative shocks. We show that bailing out the first few defaulting firms does not solve the problem, but does have the effect of alleviating considerably the global shock, as measured by the fraction of firms that are not defaulting as a consequence. This beneficial effect is the counterpart of the large vulnerability of the system of coupled firms, which are both the direct consequences of the collective self-organized endogenous behaviors of the credit ratings of the firms in our economic network.

  6. Matching osteochondritis dissecans lesions in identical twin brothers.

    Science.gov (United States)

    Richie, Lucas B; Sytsma, Mark J

    2013-09-01

    Osteochondritis dissecans is a disorder of unknown etiology that can result in fragmentation of osteochondral surfaces, most commonly of the knee, shoulder, elbow, and ankle. This may lead to sequelae of pain and an inability to participate in desired activities. Multiple theories exist as to the true cause of the disorder, but none have been fully proven. One such proposed etiology is genetic causation. Familial cases of osteochondritis dissecans are rare, yet these cases offer support to growing evidence that may support a genetic link. This article describes osteochondritis dissecans lesions of the femoral trochlea in monozygotic (identical) twins. Both twins presented with similar symptoms 1 year apart. Neither twin had any clear inciting trauma. Magnetic resonance imaging revealed osteochondral lesions in similar positions of the lateral trochlear of the same knee in both brothers. Osteochondral autograft transfer and tibial tubercle anteromedialization were performed on both patients. An identical postoperative protocol was followed, and recovery with full return to sport was comparable for the brothers. To the authors' knowledge, only 1 other case report exists of osteochondritis dissecans lesions in monozygotic twins. Although debate continues regarding the true etiology of this disorder, cases of identical twins presenting with a similar disease process are highly suggestive of a genetic component and may lead to early identification and treatment of these lesions. Continued research in the area of osteochondritis dissecans and its genetic basis is needed to completely understand this disorder. Copyright 2013, SLACK Incorporated.

  7. Environmental behaviour of radioactivity from Chernobyl: Brothers Water study

    International Nuclear Information System (INIS)

    Bonnett, P.J.P.; Appleby, P.G.; Oldfield, F.; Haworth, E.Y.; Hilton, J.; Davison, W.

    1992-01-01

    A study has been carried out to examine the short term behaviour of Chernobyl derived radionuclides together with the longer term patterns of transport of weapons fallout derived 137 Cs first studied on the Brothers Water catchment in the English Lake District in the 1970's. Chernobyl derived radiocaesium is observable in the soils and lake sediments of the catchment. 210 Pb dating and diatom analysis were used to confirm that the lake sediments sampled were undisturbed. A simple box model is used to estimate radionuclide inventories in Brothers Water Lake sediments. Estimates derived using this model are reasonably consistent with estimates obtained from a variety of other sources. (author)

  8. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Science.gov (United States)

    2010-04-01

    ... entitlement to brother's benefits may be established for any month before January 1973, based on a disability... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent, brother...

  9. Big Brother gør sit indtog

    DEFF Research Database (Denmark)

    Moeslund, Thomas B.

    2009-01-01

    På grund af frygten for terror er vi i dag parate til at acceptere en grad af overvågning, der før i tiden gav mindelser om George Orwells dystopi 1984. Teknisk er der dog betydelige udfordringer i at få IT-systemerne til at opføre sig som Big Brother. Udgivelsesdato: December...

  10. Freud on Brothers and Sisters: A Neglected Topic

    Science.gov (United States)

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  11. Propaganda in Warner Brothers World War II Cartoons.

    Science.gov (United States)

    Machowski, James Stanley; Brown, James William

    To examine the role of the animated cartoon in propaganda associated with World War II, 194 of 262 cartoons produced for theatrical release by Warner Brothers, Inc., from 1939 to 1946 were analyzed. Propaganda content was determined by the number and nature of symbols used and the cartoon's "attitudes" toward these symbols. An analysis…

  12. Commissioner for Inland Revenue V Lever Brothers and Unilever Ltd

    African Journals Online (AJOL)

    Lever Brothers, the South African tax case that formed the basis of this research, was concerned with determining the source of interest income. In its time, this was one of the landmark cases and established tax principles that were valid for 54 years, until superseded by changes to legislation. The research presented a ...

  13. Commissioner for Inland Revenue v Lever Brothers and Unilever Ltd

    African Journals Online (AJOL)

    kirstam

    21Key words: Lever Brothers and Unilever; South African income tax; source of income; interest; the “practical man”; the .... facilities, and he housed his employees in a model village of well-built homes on the factory site. ... be cancelled and any excess of the value of the shares over the debt would be adjusted by a money.

  14. Paternity testing in case of brother-sister incest.

    Science.gov (United States)

    Macan, Marijana; Uvodić, Petra; Botica, Vladimir

    2003-06-01

    We performed a paternity test in a case of incest between brother and sister. DNA from blood samples of the alleged parents and their two children was obtained with Chelex DNA extraction method and quantified with Applied Biosystems QuantiBlot quantitation kit. Polymerase chain reaction (PCR) amplification of DNA samples was performed with AmpFlSTR SGM Plus PCR amplification kit and GenePrint PowerPlex PCR amplification kit. The amplified products were separated and detected by using the Perkin Elmer's ABI PRISM trade mark 310 Genetic Analyser. DNA and data analysis of 17 loci and Amelogenin confirmed the suspicion of brother-sister incest. Since both children had inherited all of the obligate alleles from the alleged father, we could confirm with certainty of 99.999999% that the oldest brother in the family was the biological father of both children. Calculated data showed that even in a case of brother-sister incest, paternity could be proved by the analysis of Amelogenin and 17 DNA loci.

  15. Isolated Penile Torsion in Brothers: A Case Report

    Directory of Open Access Journals (Sweden)

    Metin Gunduz

    2012-04-01

    Full Text Available Penile torsion can be congenital and associated with hypospadias and chordee, or can be acquired after circumcision. The incidence of isolated neonatal penile torsion was 1.7 to 27% in the literature. The majority were between 10 and deg; and 20 and deg;. Generally, torsion was to the left in cases. The techniques for correction of penile torsion described in the literature are penile de-gloving and reattaching of skin, resection of Buck's fascia incising the base of the penis and removing angular ellipses of corporeal tissue with subsequent plication of tunica, and dorsal dartos flap rotation in severe cases. In conclusion, penile torsion may be familial. Therefore, brothers should be examined carefully. The degloving and realignment technique is successful in isolated penile torsion. [Arch Clin Exp Surg 2012; 1(2.000: 122-124

  16. Brothers with constrictive pericarditis – A novel mutation in a rare disease

    Directory of Open Access Journals (Sweden)

    Devendra V. Patil

    2016-09-01

    Full Text Available Familial constrictive pericarditis is extremely rare. We report a case of two brothers both suffering constrictive pericarditis along with having multiple painless joint deformities. Genetic workup confirmed the clinical diagnosis of camptodactyly-arthropathy-coxa vara-pericarditis (CACP syndrome CACP syndrome and also revealed a rare mutation in the causative gene.

  17. The comparison of family types in fairy tales by brothers Grimm and H. C. Andersen

    OpenAIRE

    Šček, Marjeta

    2014-01-01

    The present thesis entitled The Comparison of Family Types in Fairy Tales by Brothers Grimm and H. C. Andersen consists of two parts: the theoretical and the empirical part. The first part is a brief summary of opuses and biographies of Jacob and Wilhelm Grimm and Hans Christian Andersen, followed by a section describing several different definitions of families and family types. The second part is an analysis of ten fairy tales by brothers Grimm: The Frog King, or Iron Henry, Little Brother ...

  18. Living with a brother or sister with epilepsy: siblings' experiences.

    Science.gov (United States)

    Hames, Annette; Appleton, Richard

    2009-12-01

    There is conflicting evidence about the impact of disability upon siblings, and very little research on the siblings of children with epilepsy. There is some evidence that siblings who have less accurate information exhibit more distress. The aim of this study was to assess siblings' response to having a brother or sister with epilepsy and to begin to develop information for them. Parents of children attending paediatric neurology outpatient departments were invited to participate in a pilot study. Parents who consented to take part were asked if they had previously received information for siblings. Parents and siblings participated in a semi-structured interview and siblings were also invited to submit a personal account of living with a brother or sister who had epilepsy. Twenty-five families with a child with epilepsy aged 2.5-15 years initially agreed to take part. None of the families stated that they had ever seen or received any information specifically for siblings. Fourteen siblings from the 25 families, aged 8-25 years, provided a personal account of what it was like living with a brother or sister with epilepsy. Siblings' accounts included both negative and positive feelings, and specifically feelings of care and love for their sibling. This initial study suggests that siblings of children with epilepsy have many positive but also early negative feelings. The results are limited by the size of the study, the fact that most siblings were older sisters, and the mean time since diagnosis was 6 years. Finally, it is hoped that the personal accounts collected in this study will be published for the benefit of other siblings of children with epilepsy.

  19. Laryngologist Leon Zamenhof--brother of Dr. Esperanto.

    Science.gov (United States)

    Wincewicz, Andrzej; Sulkowska, Mariola; Musiatowicz, Marcin; Sulkowski, Stanislaw

    2009-06-01

    To reconstruct the biography of the Polish otorhinolaryngologist Leon Zamenhof (1875-1934), a brother of Ludwik Zamenhof, who is famous for invention of the international language Esperanto. Biographical information was collected from pre-World War II resources. Zamenhof developed several important new forms of treatment to help the hearing impaired. Zamenhof was especially interested in the education of deaf children and the therapy necessary to facilitate their integration into society. His significant achievements were a phonetic method of therapy for the hearing impaired and an automatic device for ear insufflation that was considered indispensable in the management of pyorrhea. In addition, Zamenhof initiated various forms of social support among physicians within the medical community of Warsaw, Poland; made health care available to children with hearing impairments; and organized a Jewish school for deaf children. Zamenhof tried to change public attitudes toward deafness, working to promote the integration of the deaf into wider society. He also translated Polish literature into Esperanto. With similar aims to his brother Ludwik, Leon Zamenhof strived to enhance and broaden communication among people who could not hear and to persuade people to change their attitudes about deafness.

  20. The Perceptions and Experiences of Adolescent Siblings Who Have a Brother with Autism Spectrum Disorder

    Science.gov (United States)

    Petalas, Michael A.; Hastings, Richard P.; Nash, Susie; Reilly, Deirdre; Dowey, Alan

    2012-01-01

    Background: There is a dearth of research on the perspectives of adolescent siblings growing up with a brother or sister with an autism spectrum disorder (ASD). Method: Semistructured interviews were used to elicit the perceptions and experiences of 12 typically developing adolescents with a brother with an ASD. Interpretative phenomenological…

  1. Living with a Brother Who Has an Autism Spectrum Disorder: A Sister's Perspective

    Science.gov (United States)

    Connell, Zara O.; Halloran, Maeve O.; Doody, Owen

    2016-01-01

    People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or sister. Services for people with ASD should provide effective support to families, which include brothers,…

  2. "Southern Pop Culture and the Literary Tradition in O Brother, Where Art Thou?"

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2009-01-01

      This essay discusses the Coen brothers movie O Brother, Where Art Thou? (2000). Rather than reading the movie as a modern retelling of The Odyssey, as most critics have done, it is read within a context of Southern literature and history. The essay points out and discusses the many references...

  3. Mothers' differential treatment of adolescent siblings: predicting college attendance of sisters versus brothers.

    Science.gov (United States)

    Bissell-Havran, Joanna M; Loken, Eric; McHale, Susan M

    2012-10-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We examined whether the difference between sisters' and brothers' reports of their mothers' expectations for, and involvement in, their education during adolescence predicted their differential odds of college attendance seven years later. Sisters were more likely than brothers to attend college, and this gap was more pronounced among non-Whites and non-Asians. Sisters also had higher grades in school than their brothers. Although there were no gender differences overall in maternal educational expectations or involvement, brothers reported greater maternal involvement than sisters in non-White and non-Asian families. After controlling for family background factors, the average of siblings' reports of maternal treatment, and differences between siblings' grades, the results revealed that as sisters reported greater maternal educational expectations than their brothers, it became more likely that only the sister rather than only the brother in the family attended college. The difference between brothers' and sisters' reports of their mothers' educational involvement and their odds of attending college showed the same pattern of association but was not statistically significant. These results suggest that within-family social comparisons may play a role in sisters' and brothers' choices about attending college.

  4. Discussing the Life of the Others: Doing Ethnography in the Brazilian Big Brother Fan Community

    Directory of Open Access Journals (Sweden)

    Bruno Campanella

    2009-05-01

    Full Text Available The aim of this paper is to present some of the initial results of ethnographic research conducted in early 2008 with the online fan community of the Brazilian Big Brother (BBB. After a brief introduction to some of the challenges faced by ethnographic work on television audiences in the last couple of decades, the current piece will explore some of the main characteristics constituting this new social space. Beyond the gossiping, and the more immediate talks about behaviors and game strategies of the Big Brother housemates, these forums sometimes trigger exchanges about Brazilian society at large, and the role of television broadcasting in general. Nonetheless, a closer inspection reveals how the debates found in the community are themselves permeated by the participants' struggle for status.

  5. Homozygous PARK7 Mutation in Parkinson’s Disease: Case Report of Two Brothers

    Directory of Open Access Journals (Sweden)

    Hülya Apaydın

    2008-06-01

    Full Text Available OBJECTIVE: Genetic studies for Parkinson’s disease (PD which have been increased during last few years have shown that parkin (PARK2, DJ-1 (PARK7 and PINK-1 (PARK6 mutations can cause autosomal recessive early-onset parkinsonism. OBJECTIVE: The aim of this study was to investigate by genetic screening methods, the presence of possible genetic mutations in two siblings who have developed PD. METHODS: In these two brothers, PD started at the age of 48 with cervical dystonia and bradykinesia on the left arm, and 56 with tremor on the right hand, respectively. Although they had a favorable response to levodopa, they developed wearing-off phenomenon without dyskinesia on the 4th year. Besides dystonia, the younger brother experienced psychosis and impulse control disorder, as well. Family history revealed first degree consanguinity and the father had also a diagnosis of PD. PD progressed rather slowly in both, but unfortunately the older brother died due to lung cancer 10 years after the initial diagnosis of PD, while he was on the stage 2 of Hoehn-Yahr scale. The younger brother is still on our follow-up at the 7th year of his PD. Informed consent was obtained and blood samples were sent to the genetic department of Juntendo University in Japan for genetic analysis. Parkin gene mutation and DJ-1 gene mutation were analyzed on the PARK7 locus, by automated direct nucleotide sequencing and performed gene dosage assay using TaqMan real-time quantitive PCR. RESULTS: After excluding the parkin mutation the presence of PARK7 was detected in both siblings with haplotype analysis. DJ-1 gene mutation analysis responsible for PARK7, revealed a deletion on intron 1. CONCLUSION: A rarely encountered PARK7 mutation was identified in two brothers having slowly progressive PD and a favorable response to levodopa, one of whom also had psychotic symptoms. As in the presented cases, the genetic studies performed on early-onset PD patients with positive family

  6. The Failure of Lehman Brothers and Merril Lynch: A Lesson for the ...

    African Journals Online (AJOL)

    DR Nneka

    afrrev.v9i2.9. The Failure of Lehman Brothers and Merril Lynch: A Lesson for the Nigerian Banking Industry. Achugbu, Austine A. Department of Banking and Finance,. Anambra State University, Igbariam Campus,. Anambra State, Nigeria.

  7. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Science.gov (United States)

    2010-04-01

    ... domiciled (see § 410.392) at the time of his death would find, under the law they would apply in determining..., brother, or sister. Where, under such law, the individual does not bear the relationship to the miner of...

  8. Do brothers and sisters of siblings with intelectual disability need the support of social work?

    OpenAIRE

    Cardová, Michaela

    2007-01-01

    This thesis explores the experience and support needs of siblings with a brother or sister with intellectual disability. Through review of what is a quite limited literature and from original qualitative research, involving interviews with siblings, the author examines their social reality, focusing especially on their relationships with their disabled brother or sister and with the wider society. Particular attention is given to identifying to what extent the siblings' lives are influenced b...

  9. The Warner Brothers and Franklin Delano Roosevelt:Connections and Collaborations

    OpenAIRE

    Cohen, Harvey

    2013-01-01

    This working paper traces the history of the Warner brothers and their Hollywood film studio, from their hardscrabble beginnings to their famous championing of a "social realist" aesthetic in their motion pictures released during the 1920s and 1930s. The pre-presidential career of Franklin Delano Roosevelt is also featured and contrasted with that of the Warner Brothers, setting up a discussion of how the Warner Bros. Studio not only supported Roosevelt financially with fundraising events but...

  10. The Montgolfier Brothers and the Invention of Aviation

    Science.gov (United States)

    Moore, Charles B.

    The first hot air balloon ascension over Paris in September 1783 has been described so many times that it and its passengers—the sheep, the rooster, and the duck—have joined Benjamin Franklin and his kite in the folklore of our culture. Not so well known is the earlier history of ballooning; that the brothers Montgolfier had demonstrated their hot air balloons repeatedly for several months prior to the ascent over Paris; or that the physicist Charles, urged onward and financed by an enthusiast, Barthélemy Faujas de Saint-Fond, launched successfully the first fabric balloon filled with hydrogen over Paris more than 3 weeks prior to the memorable ascent of the sheep, and rooster, and the duck.For all of its well-documented detail, the book is readable and enjoyable. It is a well-written but complex book in which Professor Gillispie develops a number of subjects to recreate the era in perspective. The origins and the disposition of the Montgolfiers, the industry of the period, the idea of capturing heated air are all reported in detail. The attempts to obtain government funding and the promotional activities in Paris were forerunners of the modern techniques for obtaining support of research activities.

  11. “THE BROTHERS KARAMAZOV” IN GERMAN TRANSLATIONS: TRANSLATING THE RUSSIANNESS OF DOSTOYEVSKY’S STYLE

    Directory of Open Access Journals (Sweden)

    Olga KORENEVSKAYA

    2010-11-01

    Full Text Available : The article investigates the challenges of rendering the peculiarities of Dostoyevsky’s style linked to his philosophy of man and religious attitudes in four German translations of “The Brothers Karamazov”. The category of uncertainty is intrinsic to both Russian mentality and Dostoyevsky’s writing manner. However, the textual markers of uncertainty are perceived by German translators as essentially “foreign” and therefore may hinder the readers’ understanding. The paper reveals various approaches to conveying the desired semantic effect of uncertainty in the translations and points out problematic issues.

  12. Exome sequencing identifies mutations in ABCD1 and DACH2 in two brothers with a distinct phenotype

    OpenAIRE

    Zhang, Yanliang; Liu, Yanhui; Li, Ya; Duan, Yong; Zhang, Keyun; Wang, Junwang; Dai, Yong

    2014-01-01

    Background We report on two brothers with a distinct syndromic phenotype and explore the potential pathogenic cause. Methods Cytogenetic tests and exome sequencing were performed on the two brothers and their parents. Variants detected by exome sequencing were validated by Sanger sequencing. Results The main phenotype of the two brothers included congenital language disorder, growth retardation, intellectual disability, difficulty in standing and walking, and urinary and fecal incontinence. T...

  13. Mortality and health-related habits in 900 Finnish former elite athletes and their brothers.

    Science.gov (United States)

    Kontro, Titta Katariina; Sarna, Seppo; Kaprio, Jaakko; Kujala, Urho M

    2018-01-01

    There is conflicting evidence on the associations between participation in vigorous sports, health habits, familial factors and subsequent mortality. We investigated all-cause mortality and health-related behaviour among former elite athletes and their brothers. The mortality of Finnish male former elite athletes, who had represented Finland between 1920 and 1965 (n=900) and their age-matched brothers (n=900), was followed from the time when athlete started an elite athlete career until 31 December 2015. The age-adjusted HRs were calculated by a paired Cox proportional hazards model. In 2001, surviving participants (n=199 athletes and n=199 age-matched brothers) reported their self-rated health (SRH), physical activity, alcohol consumption and smoking habits in the questionnaire. During the total follow-up period, 1296 deaths (72% of the cohort) occurred. The age-adjusted HRs for all-cause mortality in former athletes was 0.75 (95% CI 0.65 to 0.87, Psports and 72.2 years for power sports athletes, and 77.5, 73.7 and 72.2 years for their age-matched brothers, respectively. In 2001, compared with their brothers, former athletes smoked less (Pathletes are more physically active, smoke less, have better self-rated health and live longer than their brothers. Genetic differences between athletes and brothers, aerobic training for endurance elite sports and a healthier lifestyle may all contribute to reduced mortality. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Brother of CDO (BOC) expression in equine articular cartilage.

    Science.gov (United States)

    Vanderman, K S; Tremblay, M; Zhu, W; Shimojo, M; Mienaltowski, M J; Coleman, S J; MacLeod, J N

    2011-04-01

    Brother of CDO (BOC) is a cell surface receptor that derives its name from the structurally related protein, cell adhesion molecule-related/down-regulated by oncogenes (CDO, sometimes CDON). High levels of BOC mRNA and protein expression have been described in embryonic tissues with active cell proliferation and ongoing cellular differentiation(1,2). A microarray-based screen of RNA isolated from 11 different adult equine tissues unexpectedly identified BOC as having an expression pattern restricted to articular cartilage. The objective of this study was to further investigate BOC expression in adult articular cartilage relative to other tissues. Both RT-qPCR and mRNA sequencing confirmed the microarray data. Steady state BOC mRNA levels in articular cartilage were substantially higher than in the other adult tissues tested, neonatal tendon, placenta, and whole embryo. The expression of BOC displayed a pattern of tissue specificity comparable to well established cartilage matrix protein biomarkers. BOC mRNA levels in articular cartilage increased with age, but were rapidly down-regulated when chondrocytes were enzymatically isolated from the cartilage matrix and expanded in monolayer culture. Relative expression patterns of CDO were broadly similar, but displayed lower fold change differences. A functional role in articular cartilage that involves Hedgehog signaling is suggested by the known binding affinity of BOC for all three Hedgehog ligands. These data also extend BOC and CDO biology to a post-mitotic and highly differentiated cell type within a mature tissue. Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  15. Extreme right-handedness, older brothers, and sexual orientation in men.

    Science.gov (United States)

    Bogaert, Anthony F

    2007-01-01

    Two of the most consistent correlates of sexual orientation in men are handedness and fraternal birth order (i.e., number of older brothers). In the present study, the relationship among handedness, older brothers, and sexual orientation was studied in 4 samples of heterosexual and gay or bisexual men (N = 944). Unlike previous studies, which have only observed an increased rate of non-right-handedness in gay or bisexual men relative to heterosexual men, an elevated rate of extreme right-handedness was found in gay or bisexual men relative to heterosexual men. The results also demonstrated that older brothers moderate the relationship between handedness and sexual orientation. Specifically, older brothers increase the odds of being gay or bisexual in moderate right-handers only; in both non-right-handers and extreme right-handers, older brothers do not affect (or decrease) the odds of being gay or bisexual. The results have implications for an early neurodevelopmental origin to sexual orientation in men. (c) 2007 APA, all rights reserved.

  16. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    Energy Technology Data Exchange (ETDEWEB)

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S. [Battelle Marine Sciences Laboratory, Sequim, Washington (United States)

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  17. A Monument as a Text, or The Message of the Brothers Dostoevsky

    Directory of Open Access Journals (Sweden)

    Vladimir Zakharov

    2014-12-01

    Full Text Available The article considers the circumstances of the creation of a monument to the writer's mother Maria Fyodorovna Dostoevskaya. Mikhail Andreevich, father of the brothers Dostoevsky, asked Mikhail and Fyodor to compose the text for the monument. In March and April of 1837 the brothers worked out the idea and conception of the monument, wrote the text of the first and fourth epigraphs, chose evangelic verses and an epitaph of N.M. Karamzin. This was their first collective act of creative work embodied in stone. The monument is not only a symbol of love and sorrow for their mother’s death but also hope for her salvation and future resurrection. The brothers’ words and those chosen from the Gospel as well as the Karamzin’s ones have one more meaning. These convey a sense of beingness and an Easter idea of individual creative work. It is necessary to renew the tomb of Maria Fyodorovna Dostoevskaya and bring the monument back to Lazarevskoye cemetery in Moscow.

  18. Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers

    DEFF Research Database (Denmark)

    Bandak, M.; Jorgensen, N.; Juul, A.

    2017-01-01

    was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular...... cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III...

  19. Intrafamilial Sexual Abuse: Brother-Sister Incest Does Not Differ from Father-Daughter and Stepfather-Stepdaughter Incest.

    Science.gov (United States)

    Cyr, Mireille; Wright, John; McDuff, Pierre; Perron, Alain

    2002-01-01

    A study compared 72 girls (ages 5-16) sexually abused by brothers, fathers, or stepfathers. Results suggested few differences in characteristics of sexual abuse. However, penetration was much more frequent in the sibling incest group. More victims of fathers and brothers manifested clinically significant distress (90%), than stepfather victims…

  20. Incestuous sisters: mate preference for brothers over unrelated males in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Adeline Loyau

    Full Text Available The literature is full of examples of inbreeding avoidance, while recent mathematical models predict that inbreeding tolerance or even inbreeding preference should be expected under several realistic conditions like e.g. polygyny. We investigated male and female mate preferences with respect to relatedness in the fruit fly D. melanogaster. Experiments offered the choice between a first order relative (full-sibling or parent and an unrelated individual with the same age and mating history. We found that females significantly preferred mating with their brothers, thus supporting inbreeding preference. Moreover, females did not avoid mating with their fathers, and males did not avoid mating with their sisters, thus supporting inbreeding tolerance. Our experiments therefore add empirical evidence for inbreeding preference, which strengthens the prediction that inbreeding tolerance and preference can evolve under specific circumstances through the positive effects on inclusive fitness.

  1. Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype

    Directory of Open Access Journals (Sweden)

    Nadia Skauli

    2016-11-01

    Full Text Available Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3, characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmorphisms, and skeletal, ophthalmological, cardiac, and genitourinary abnormalities. We report a novel homozygous PIGT missense variant c.1079G>T (p.Gly360Val in two brothers with several of the typical features of MCAHS3, but in addition, pyramidal tract neurological signs. Notably, they are the first patients with MCAHS3 without skeletal, cardiac, or genitourinary anomalies. PIGT encodes a crucial subunit of the glycosylphosphatidylinositol (GPI transamidase complex, which catalyzes the attachment of proteins to GPI-anchors, attaching the proteins to the cell membrane. In vitro studies in cells from the two brothers showed reduced levels of GPI-anchors and GPI-anchored proteins on the cell surface, supporting the pathogenicity of the novel PIGT variant.

  2. When Your "Problem" Becomes Mine: Adult Female Siblings' Perspectives of Having a Brother with a Disability

    Science.gov (United States)

    Pompeo, Michelle N.

    2009-01-01

    This study is a retrospective look at adult female siblings' perspectives of their childhoods and present identities based on having a brother with a disability. This paper focuses on siblings' experiences within educational and public domains, and how such experiences have shaped their personalities and career choices. Qualitative findings were…

  3. A Thousand Lights [and] A Thousand Lights: Teacher and Parent Guide. Brothers Series.

    Science.gov (United States)

    Benton, Hope

    This book for children (ages 8 to 14) and the accompanying teacher/parent guide present the story of two brothers, one of whom has a severe hearing impairment, who climb up Mt. Fuji in Japan. Information on the disability is presented subtly and incidentally to encourage the reader to relate more personally and foster a deeper level of acceptance…

  4. Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma.

    Science.gov (United States)

    Ji, Jianling; Quindipan, Catherine; Parham, David; Shen, Lishuang; Ruble, David; Bootwalla, Moiz; Maglinte, Dennis T; Gai, Xiaowu; Saitta, Sulagna C; Biegel, Jaclyn A; Mascarenhas, Leo

    2017-05-01

    We report a family in which two brothers had an undiagnosed genetic disorder comprised of dysmorphic features, microcephaly, severe intellectual disability (non-verbal), mild anemia, and cryptorchidism. Both developed osteosarcoma. Trio exome sequencing (using blood samples from the younger brother and both parents) was performed and a nonsense NM_000489.4:c.7156C>T (p.Arg2386*) mutation in the ATRX gene was identified in the proband (hemizygous) and in the mother's peripheral blood DNA (heterozygous). The mother is healthy, does not exhibit any clinical manifestations of ATR-X syndrome and there was no family history of cancer. The same hemizygous pathogenic variant was confirmed in the affected older brother's skin tissue by subsequent Sanger sequencing. Chromosomal microarray studies of both brothers' osteosarcomas revealed complex copy number alterations consistent with the clinical diagnosis of osteosarcoma. Recently, somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome. This is the first report of osteosarcoma diagnosed in two males with ATR-X syndrome, suggesting a potential increased risk for cancer in patients with this disorder. © 2017 Wiley Periodicals, Inc.

  5. 3 CFR 8466 - Proclamation 8466 of December 16, 2009. Wright Brothers Day, 2009

    Science.gov (United States)

    2010-01-01

    ... alter our world. Today, we honor the enduring American spirit of creativity and innovation that made the..., the Wright Brothers’ success embodies our Nation’s proud tradition of entrepreneurship. In pursuit of... failures, a skeptical public, and the sheer danger of their endeavors often tempted the brothers to quit...

  6. "My Brother": The Recovery of Rocky in Leslie Marmon Silko's "Ceremony"

    Science.gov (United States)

    Bassett, Troy J.

    2004-01-01

    In Leslie Marmon Silko's novel "Ceremony", Rocky appears as Tayo's childhood friend and "brother" and also as a major part of Tayo's prisoner-of-war experiences in the Pacific during World War II. The interpretation of the novel presents both Rocky and Tayo as two men destroyed by the war, the former physically and the latter spiritually.

  7. Traits of ADHD and autism in girls with a twin brother

    DEFF Research Database (Denmark)

    Attermann, Jørn; Obel, Carsten; Bilenberg, Niels

    2012-01-01

    . In conclusion, we found that female twins with a twin brother scored significantly lower in parent-reported traits of ADHD and ASD than those with a twin sister. The reason for this may be parental reporting bias, or confounding by unmeasured variables, or a causal effect of an intrauterine environment modified...

  8. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    Science.gov (United States)

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  9. Two Brothers, Two Cities: Music Education in Boston and Cincinnati from 1830-1844

    Science.gov (United States)

    Lenzo, Terri Brown; Resta, Craig

    2011-01-01

    The birth of American music education is often attributed solely to Lowell Mason in Boston. His younger brother Timothy, however, was also active at the same time in Cincinnati. This study traces the roots of music education in both cities, but highlights the rarely cited accomplishments of Timothy Mason and his colleagues. Using historical…

  10. Hiper-realidade versus sedução: o paradoxo do Big Brother Brasil

    Directory of Open Access Journals (Sweden)

    Felipe da Silva Polydoro

    2011-07-01

    Full Text Available ResumoNeste artigo, jogamos Baudrillard contra si próprio na análise do programa Big Brother Brasil (BBB. Primeiro, desenvolvemos a afirmação do teórico de que este reality show resume-se a refletir o estado de banalidade de uma cultura hiper-real. Em seguida, propomos uma reversão nesta argumentação, ao apontar, no BBB, sinais de um efeito sedutor. No início, recuperarmos alguns pontos da teoria do autor francês e evidenciamos o conceito moderno de realidade, aquilo que desaparece na era da simulação.

  11. Cobb′s collar occurring in two brothers in a family: A rare entity revisited

    Directory of Open Access Journals (Sweden)

    Partha Pal

    2014-01-01

    Full Text Available Most urethral strictures arise from iatrogenic, traumatic, or inflammatory causes. We report the familial occurrence of a congenital bulbar urethral stricture in two brothers. Retrograde and voiding cystourethrography was performed. A Cobb′s collar was diagnosed after radiological and endoscopic evaluation in both cases and was successfully managed with urethroplasty. Cobb′s collar is a rarely recognized cause of a membranous stricture of bulbar urethra that can lead to several urinary problems. In cases of adolescent and young adults presenting with symptoms of progressive urinary obstruction and enuresis with or without urinary tract infection, Cobb′s collar can be seen as a minor constriction in the bulbar urethra, but is not frequently symptomatic, and the familial occurrence of such a stricture is even rarer.

  12. CONFESSION AND REPENTANCE IN F. M. DOSTOYEVSKY'S NOVEL THE BROTHERS KARAMAZOV

    Directory of Open Access Journals (Sweden)

    Denis Vladimirovich Vasil'ev

    2014-11-01

    Full Text Available The article deals with the meaning of a penitential confession in Fyodor Dostoyevsky's novel The Brothers Karamazov. It is noted that the penitential confession in the novel exempts from the burden of guilt, allowing the confessor to get rid of spiritual suff erings through the compassion of the person who accepts the confession and shares the guilt with the sinner. It is emphasized that repentance is inseparably linked with overcoming the sense of shame before public exposure and self-obsession with one’s reputation. The attention is paid to mutual confessions in the novel aft er which the heroes step on the path towards transformation. It is concluded that penitential confessions of heroes result in their revival and spiritual renewal, as each of them is given a chance to endure spiritual revolution, to overcome the "hell" and to confirm the validity of Zosima’s idea about common guilt and responsibility.

  13. Old Instruments, New Agendas: The Chemical Brothers and the ARP 2600

    Directory of Open Access Journals (Sweden)

    Hans T. Zeiner-Henriksen

    2014-06-01

    Full Text Available A preference for old vintage music equipment is widespread in electronic dance music. My point of departure for a discussion of this phenomenon is an interview from Keyboard magazine in which the members of the production duo the Chemical Brothers proclaim their fascination with an old analogue synthesizer. Two diverse theoretical approaches will inform and nuance my narrative here. Wiebe E. Bijker’s sociotechnical approach to the development of technology will highlight stages and processes in the transition from analogue to digital technology. In addition, Sarah Thornton’s concept of subcultural capital will direct attention to the old instrument as a prestige item that serves to maintain power structures within the electronic dance music culture.

  14. From Glass Architecture to Big Brother: Scenes from a Cultural History of Transparency

    Directory of Open Access Journals (Sweden)

    Scott McQuire

    2013-09-01

    Full Text Available In this essay, I want to reposition the Big Brother phenomenon in the context of an earlier debate about domestic space which occurred during the emergence of architectural modernism in the first decades of the twentieth century. At issue then was the physical reconstruction of the home, particularly through the increasing use of glass as a design element. While glass architecture is even more prevalent in the present, its spatial impact—particularly in terms of its capacity to alter the relationship between the ‘inside’ and the ‘outside’—has now been matched or exceeded in many respects by the effects of electronic media. By tracing the parallel between the unsettling spatial effects produced by both glass construction and the electronic screen, I will sketch a cultural logic linking the modernist project of architectural transparency to the contemporary repositioning of the home as an interactive media centre.

  15. Reluctant Romantics – On the fairy tale poetics of the Brothers Grimm and their relationship to German Romanticism

    Directory of Open Access Journals (Sweden)

    Isabel dos Santos

    2014-12-01

    Full Text Available The legacy of the Brothers Grimm continues to fascinate readers and researchers alike. The 200-year anniversary of the first publication of their fairy tales sparked a renewed interest in the life, work and times of the brothers. Fascinated by the past, by the political present and by the literary future of Romanticism, the Brothers Grimm stayed together in an unusual working union. They established what was to become German philology and published many invaluable works on language and history, myths and folk tales. This article will focus on the brothers’ place in German Romanticism through their contribution of fairy tales. The period was marked by political and philosophical thought that emphasised authentic experienced and the spiritual unity of art, science and philosophy. There was a strong call for national emancipation. Literature was required to embody this unity through an established national literature founded on German folk traditions. The Grimms seemed to have heeded that call. But a careful study reveals that their intentions were motivated less by the literary movement than by their own strong convictions which they upheld even at the cost of compromising the authenticity they claimed to uphold in their poetics. The many controversies regarding the origins, collection and editing of the fairy tales is inextricably linked to the brothers’ difficult relationship with the Romantic Movement. Two hundred years later, this article seeks to give an appraisal of the Brothers’ motivation for their poetics and of the research conducted thus far.

  16. Extreme intrafamilial variability of Saudi brothers with primary hyperoxaluria type 1

    Directory of Open Access Journals (Sweden)

    Alfadhel M

    2012-08-01

    Full Text Available Majid Alfadhel,1 Khalid A Alhasan,2 Mohammed Alotaibi,3 Khalid Al Fakeeh41Division of Genetics, Department of Pediatrics, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia; 2Division of Nephrology Department of Pediatrics, King Saud University King Khalid University Hospital, Riyadh, Saudi Arabia; 3Department of Radiology, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia; 4Division of Nephrology, Department of Pediatrics, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi ArabiaBackground: Primary hyperoxaluria type 1 (PH1 is characterized by progressive renal insufficiency culminating in end-stage renal disease, and a wide range of clinical features related to systemic oxalosis in different organs. It is caused by autosomal recessive deficiency of alanine:glyoxylate aminotransferase due to a defect in AGXT gene.Case report: Two brothers (one 6 months old; the other 2 years old presented with acute renal failure and urinary tract infection respectively. PH1 was confirmed by high urinary oxalate level, demonstration of oxalate crystals in bone biopsy, and pathogenic homozygous known AGXT gene mutation. Despite the same genetic background, same sex, and shared environment, the outcome of the two siblings differs widely. While one of them died earlier with end-stage renal disease and multiorgan failure caused by systemic oxalosis, the older brother is pyridoxine responsive with normal development and renal function.Conclusion: Clinicians should be aware of extreme intrafamilial variability of PH1 and international registries are needed to characterize the genotype-phenotype correlation in such disorder.Keywords: primary hyperoxaluria, oxalosis, PH1, intrafamilial variability

  17. Reproductive hormones and metabolic syndrome in 24 testicular cancer survivors and their biological brothers.

    Science.gov (United States)

    Bandak, M; Jørgensen, N; Juul, A; Lauritsen, J; Kier, M G G; Mortensen, M S; Oturai, P S; Mortensen, J; Hojman, P; Helge, J W; Daugaard, G

    2017-07-01

    Testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to healthy controls. However, because of the fetal etiology of testicular cancer, familial unrelated healthy men might not be an optimal control group. The objective of this study was to clarify if testicular cancer survivors have impaired gonadal function and increased risk of metabolic syndrome when compared to their biological brothers. A cross-sectional study of testicular cancer survivors (ClinicalTrials.gov number, NCT02240966) was conducted between 2014 and 2016. Of 158 testicular cancer survivors included, 24 had a biological brother who accepted to participate in the study. Serum levels of reproductive hormones and prevalence of metabolic syndrome according to International Diabetes Federation Criteria and National Cholesterol Education Program (Adult Treatment Panel III) criteria comprised the main outcome measures of the study. Median age was similar in testicular cancer survivors and their biological brothers [44 years (IQR 39-50) vs. 46 (40-53) years respectively (p = 0.1)]. In testicular cancer survivors, follow-up since treatment was 12 years (7-19). Serum levels of luteinizing hormone and follicle-stimulating hormone were elevated (p ≤ 0.001), while total testosterone, free testosterone, inhibin B and anti-Müllerian hormone were lower (p ≤ 0.001) in testicular cancer survivors than in their biological brothers. The prevalence of metabolic syndrome was similar and apart from HDL-cholesterol, which was lower in testicular cancer survivors (p = 0.01); there were no differences in the individual components of the metabolic syndrome between testicular cancer survivors and their brothers. In conclusion, gonadal function was impaired in testicular cancer survivors, while we did not detect any difference in the prevalence of metabolic syndrome between testicular cancer survivors and their biological brothers. © 2017 American

  18. Undersöka och förbättra Brother Finlands kommunikation, prissättning och leveransserviceelement

    OpenAIRE

    Forssell, Ronny; Nordström, Niklas

    2012-01-01

    Den nuvarande ekonomiska situationen har förorsakat en allt hårdare konkurrens på marknaderna vilket har lett till att företag hamnar kämpa för sina kundrelationer kraftigare. För Brother Finlands verksamhet spelar återförsäljarna en stor roll och därmed vill Brother Finland vara säker på att återförsäljarna är nöjda också i framtiden. Detta var orsaken till att Brother Finland blev intresserad av ett projekt i kundundersökningssyfte. Tre teman som Brother Finland såg som viktiga för en funge...

  19. Brothers and reduction of the birth weight of later-born siblings

    DEFF Research Database (Denmark)

    Nielsen, Henriette Svarre; Mortensen, Laust; Nygaard, Ulrikka

    2008-01-01

    It has been speculated whether maternal immune responses against male-specific minor histocompatibility (H-Y) antigens affect pregnancies negatively. This study explores, on a population level, whether previous births of boys compared with girls are associated with a decrease in birth weight...... of later-born siblings. The population was identified in the Danish Birth Registry and consisted of all Danish women who gave birth to their first-born singleton from 1980 to 1998. The women were followed until 2004, and their subsequent births were recorded. A total of 545,839 second- to fourth......-born children were identified. The authors used linear regression to analyze the association between sex of preceding children and birth weight of subsequent siblings. Brothers compared with sisters reduced the birth weight of later-born siblings. One or two brothers, respectively, reduced the mean birth weight...

  20. Catholic nursing sisters and brothers and racial justice in mid-20th-century America.

    Science.gov (United States)

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing's work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses' work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of "bearing witness," a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely.

  1. ATRX mutation in two adult brothers with non-specific moderate intellectual disability identified by exome sequencing

    OpenAIRE

    Moncini, S.; Bedeschi, M.F.; Castronovo, P.; Crippa, M.; Calvello, M.; Garghentino, R.R.; Scuvera, G.; Finelli, P.; Venturin, M.

    2013-01-01

    In this report, we describe two adult brothers affected by moderate non-specific intellectual disability (ID). They showed minor facial anomalies, not clearly ascribable to any specific syndromic patterns, microcephaly, brachydactyly and broad toes. Both brothers presented seizures. Karyotype, subtelomeric and FMR1 analysis were normal in both cases. We performed array-CGH analysis that revealed no copy-number variations potentially associated with ID. Subsequent exome sequence analysis allow...

  2. X-linked mental retardation syndrome: Three brothers with the Brooks-Wisniewski-Brown syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Morava, E.; Storcz, J.; Kosztolanyi, G. [Univ. Medical School, Pecs (Hungary)

    1996-07-12

    We report on 3 brothers with growth and mental retardation, bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, wide bulbous nose, small mouth, myopia, and spastic diplegia. The patients were born to normal and non-consanguineous parents. The similarity of our cases with those recently reported by Brooks et al. supports their suggestion that these patients are representative of a distinct entity. 8 refs., 3 figs., 1 tab.

  3. On Brothers and Sisters: South Asian and Japanese Idea Systems and their Consequences

    OpenAIRE

    Lyon, Stephen M.

    2017-01-01

    The role expectations of cross siblings varies across culture. Such expectations, while not rigidly prescribing actual behaviors nevertheless influences relations between brothers and sisters in observable ways. In South Asia, a cultural rhetoric of sororal sacrifice and support coupled with fraternal protection are commonplace. While such noble sibling roles are regularly transgressed they remain powerful idioms of the relationship and transgressions require appropriate cultural justificatio...

  4. A new syndrome: multiple congenital abnormalities and mental retardation in two brothers.

    Science.gov (United States)

    Dundar, M; Ozdemir, S Y; Fryns, J P

    2012-01-01

    In this report we present two brothers with abnormal neurological development, hypotonia, short stature, pylorus stenosis, pectus excavatum, brachycephaly due to craniosynostosis, frontal bossing, depressed nasal bridge, high arched-wide palate, downslant palpebral fissures, low-set, large ears, thin upper lip and bilateral cryptorchidism. The brothers were born to a couple of second cousins and were the third and fourth pregnancies of the mother. The father, the mother and the eldest sibling were phenotypically and chromosomally normal. The clinical findings of the brothers were found to be similar. These clinical findings were compared with syndromes showing some of the symptoms, namely Apert, FG, Floating-Harbor, Shprintzen-Goldberg and Rett Syndromes. However, when the findings were detailed, we observed that they did not match completely any of the syndromes in a discernable way. The MECP2 gene mutation was analysed because of mental retardation, poor neurological evolution and large ears, but no mutation was found. So these cases are presented as a new syndrome with apparent autosomal recessive inheritance.

  5. Phelan-McDermid syndrome in two adult brothers: atypical bipolar disorder as its psychopathological phenotype?

    Directory of Open Access Journals (Sweden)

    Verhoeven WMA

    2012-04-01

    Full Text Available Willem MA Verhoeven1,2, Jos IM Egger1,3,4, Marjolein H Willemsen5, Gert JM de Leijer6, Tjitske Kleefstra51Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray, 2Erasmus University Medical Centre, Department of Psychiatry, Rotterdam, 3Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, 4Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, 5Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, 6Dichterbij, Institutes for Intellectual Disabilities, Gennep, The NetherlandsAbstract: The 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. Its behavioral phenotype comprises sleep disturbances, communication deficits, and motor perseverations. Data on psychological dysfunctions are so far not available. Previous studies have suggested that the loss of one copy of the gene SH3 and multiple ankyrin repeat domains 3 (SHANK3 is related to the neurobehavioral phenotype. Additional genes proximal to SHANK3 are also likely to play a role in the phenotype of patients with larger deletions. The present paper describes two adult brothers with an identical 2.15 Mb 22qter (22q13.32q13.33 deletion, of whom the youngest was referred for evaluation of recurrent mood changes. In both patients, magnetic resonance imaging of the brain showed hypoplasia of the vermis cerebelli. Extensive clinical examinations led to a final diagnosis of atypical bipolar disorder, of which symptoms fully remitted during treatment with a mood stabilizer. In the older brother, a similar psychopathological picture appeared to be present, although less severe and with a later onset. It is concluded that the behavioral phenotype of the 22q13.3 deletion syndrome comprises absent or delayed speech and perseverations

  6. Power in Play: A Foucauldian Reading of A.O. Soyinka’s The Trials of Brother Jero

    Directory of Open Access Journals (Sweden)

    Mahboobeh Davoodifar

    2015-12-01

    Full Text Available This work utilizes Foucault’s articulations on the power strategies of our contemporary society. To him the subject’s constitution is never a purely passive effect of power on the subject but requires the subject’s own activity. This necessitates the existence of a dynamic, mutually affecting relationship, implying that one can be both dominated and dominate at different times and in different contexts. This article aims to analyze the Nigerian Noble Laureate, Wole Soyinka’s play The Trials of Brother Jero, a prophetical play that criticizes the ills of society through its satirical depiction, in the light of Foucault’s conceptualizations on power. To do this, the article first clarifies Foucault’s mature understanding of the operation of power and then attempts to provide an in-depth analysis of the structure of the power regime and its relations in the play, tactics of domination, and more importantly, the characters’ relations to the existing system of power. The study of the language and the dialogue of the main characters, Brother Jero, Amope, Chume and a Member of Federation House not only exposes the sources of operating power relations, but it also highlights the characters’ desire for power and the way it flows and slips from one character to another. The findings of the paper reveals that power is not concentrated on merely one character or institution within the play, rather, it circulates, and through the active resistance of the dominated characters, it constantly engenders new meanings within the structure of the play. In The Trials of Brother Jero, different characters have the desire to use power against each other and the resistance of each of them indicates that power is neither possessive nor repressive. Keywords: Michel Foucault, Power, Pastoral Power, Resistance, Wole Soyinka

  7. Exome sequencing identifies mutations in ABCD1 and DACH2 in two brothers with a distinct phenotype.

    Science.gov (United States)

    Zhang, Yanliang; Liu, Yanhui; Li, Ya; Duan, Yong; Zhang, Keyun; Wang, Junwang; Dai, Yong

    2014-09-19

    We report on two brothers with a distinct syndromic phenotype and explore the potential pathogenic cause. Cytogenetic tests and exome sequencing were performed on the two brothers and their parents. Variants detected by exome sequencing were validated by Sanger sequencing. The main phenotype of the two brothers included congenital language disorder, growth retardation, intellectual disability, difficulty in standing and walking, and urinary and fecal incontinence. To the best of our knowledge, no similar phenotype has been reported previously. No abnormalities were detected by G-banding chromosome analysis or array comparative genomic hybridization. However, exome sequencing revealed novel mutations in the ATP-binding cassette, sub-family D member 1 (ABCD1) and Dachshund homolog 2 (DACH2) genes in both brothers. The ABCD1 mutation was a missense mutation c.1126G > C in exon 3 leading to a p.E376Q substitution. The DACH2 mutation was also a missense mutation c.1069A > T in exon 6, leading to a p.S357C substitution. The mother was an asymptomatic heterozygous carrier. Plasma levels of very-long-chain fatty acids were increased in both brothers, suggesting a diagnosis of adrenoleukodystrophy (ALD); however, their phenotype was not compatible with any reported forms of ALD. DACH2 plays an important role in the regulation of brain and limb development, suggesting that this mutation may be involved in the phenotype of the two brothers. The distinct phenotype demonstrated by these two brothers might represent a new form of ALD or a new syndrome. The combination of mutations in ABCD1 and DACH2 provides a plausible mechanism for this phenotype.

  8. 'The brothers Karamazov' and 'On the open road': F. M. Dostoevsky and Steve Tesich's moral imperative

    Directory of Open Access Journals (Sweden)

    Šoškić Radoje V.

    2012-01-01

    Full Text Available The present paper strives to analyze the play On the Open Road, the most famous and most popular play by American-Serbian playwright and screenwriter Steve Tesich, comparing some of its elements and ideas to F. M. Dostoevsky's novel The Brothers Karamazov, whose episodic interpolation yet its moral centre - the legend of the Grand Inquisitor, inspired Tesich to use the motif of Christ's Second Coming in his play. In this play, Tesich deliberately resorts to allegory in order to critically perceive and react to the growing deterioration of the moral sensibility of Western civilization embroiled in hypocrisy and lies. The murder of Christ, from Tesich's perspective, is a dramatic example of the process of killing what is best in man, a process that is constantly repeated in the dehumanized social order that is imposed by force, and persists due to the use of force. Tesich, as well as his contemporary Arthur Miller, dramatizes the killing of God in man as the killing and drying up of man's creative potentialities and conscience. .

  9. Sicilian family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and lethal lung disease in one of the affected brothers.

    Science.gov (United States)

    De Luca, Filippo; Valenzise, Mariella; Alaggio, Rita; Arrigo, Teresa; Crisafulli, Giuseppe; Salzano, Giuseppina; Cervato, Sara; Mariniello, Barbara; Lazzarotto, Francesca; Betterle, Corrado

    2008-11-01

    We report the clinical and immunological features of the autoimmune regulator gene (AIRE) in two Sicilian brothers with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). They were compound heterozygotes with R203X/R257X. Both had oral candidiasis since the first year of life and later developed hypoparathyroidism and Addison disease. The elder brother had experienced recurrent lower respiratory infections since 5 years of age and over the years developed severe obstructive lung disease with bronchiectasis, which led to death at 18 years of age. Both brothers had circulating autoantibodies against tryptophan hydroxylase and serotonin-producing cells were absent in the duodenal mucosa. This was associated with intestinal dysfunction in only the elder brother. (1) In the first Sicilian family with APECED reported up to now we found a heterozygous mutation that had been previously reported only once. (2) In the older brother of this family we observed a severe and lethal lung disease; this case adds to a growing literature describing this association between APECED and respiratory illnesses. (3) Tryptophan hydroxylase antibodies might be hypothesized to be the marker of an autoimmune gastrointestinal illness possibly associated with APECED.

  10. Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1 Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis

    Directory of Open Access Journals (Sweden)

    Tilman Jobst-Schwan

    2015-08-01

    Full Text Available Background/Aims: Hypercalcemia can result in nephrocalcinosis/nephrolithiasis and may lead to renal failure. Idiopathic infantile hypercalcemia is caused by mutations of the CYP24A1 gene, which regulates vitamin D activity. Classically infants present with hypercalcemia. Recently, a number of individuals have been reported with late onset clinical manifestation or late diagnosis in adulthood. All these patients are believed to show hypercalciuria. Methods: We report a 24 year old patient of healthy consanguine parents. Genetic analysis was performed by Sanger sequencing of the CYP24A1 gene in the index patient and targeted exon 2 analysis of all other family members. Results: The patient was hospitalized with severe malaise during an acute EBV-infection. He showed hypercalcemia > 3mmol/l and acute, hypovolemic renal failure with profound nephrocalcinosis, but no hypercalciuria. Genetic workup revealed a homozygous loss-of-function mutation p.E143del in the CYP24A1 gene. His clinically asymptomatic brother showed nephrocalcinosis of lesser degree. Repeatedly, low parathyroid hormone levels were detected in both brothers. Conclusion: This family displays the highly variable phenotype of CYP24A1 biallelic mutation carriers. CYP24A1 associated disease is an important differential diagnosis for the workup and counseling of infants as well as adults with hypercalcemia since a proper genetic diagnosis may result in therapeutic consequences.

  11. Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities.

    Science.gov (United States)

    Mroske, Cameron; Rasmussen, Kristen; Shinde, Deepali N; Huether, Robert; Powis, Zoe; Lu, Hsiao-Mei; Baxter, Ruth M; McPherson, Elizabeth; Tang, Sha

    2015-11-05

    In humans, Mammalian Target of Rapamycin (MTOR) encodes a 300 kDa serine/ threonine protein kinase that is ubiquitously expressed, particularly at high levels in brain. MTOR functions as an integrator of multiple cellular processes, and in so doing either directly or indirectly regulates the phosphorylation of at least 800 proteins. While somatic MTOR mutations have been recognized in tumors for many years, and more recently in hemimegalencephaly, germline MTOR mutations have rarely been described. We report the successful application of family-trio Diagnostic Exome Sequencing (DES) to identify the underlying molecular etiology in two brothers with multiple neurological and developmental lesions, and for whom previous testing was non-diagnostic. The affected brothers, who were 6 and 23 years of age at the time of DES, presented symptoms including but not limited to mild Autism Spectrum Disorder (ASD), megalencephaly, gross motor skill delay, cryptorchidism and bilateral iris coloboma. Importantly, we determined that each affected brother harbored the MTOR missense alteration p.E1799K (c.5395G>A). This exact variant has been previously identified in multiple independent human somatic cancer samples and has been shown to result in increased MTOR activation. Further, recent independent reports describe two unrelated families in whom p.E1799K co-segregated with megalencephaly and intellectual disability (ID); in both cases, p.E1799K was shown to have originated due to germline mosaicism. In the case of the family reported herein, the absence of p.E1799K in genomic DNA extracted from the blood of either parent suggests that this alteration most likely arose due to gonadal mosaicism. Further, the p.E1799K variant exerts its effect by a gain-of-function (GOF), autosomal dominant mechanism. Herein, we describe the use of DES to uncover an activating MTOR missense alteration of gonadal mosaic origin that is likely to be the causative mutation in two brothers who present

  12. The first mutation in CNGA2 in two brothers with anosmia

    DEFF Research Database (Denmark)

    Karstensen, H G; Mang, Y; Fark, T

    2015-01-01

    that the cyclic nucleotide-gated channel subunit CNGA2, expressed in the olfactory epithelium has a crucial role in olfactory signal transduction. We have identified a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with ICA using exome sequencing. No additional mutations in CNGA2 were...... identified in a cohort of 31 non-related ICA individuals. Magnetic resonance brain imaging revealed diminished olfactory bulbs and flattened olfactory sulci. This is the first report of a mutation in the cyclic nucleotide-gated gene CNGA2 and supports the critical role of this gene in human olfaction....

  13. [Two pairs of brothers with juvenile idiopathic arthritis (JIA): case reports].

    Science.gov (United States)

    Robazzi, Teresa Cristina M V; Rios, Gabriela; Castro, Catarina

    2015-01-01

    This is a case report of juvenile idiopathic arthritis (JIA) in two pairs of brothers followed in the department of pediatric rheumatology, Universidade Federal da Bahia. Genetic involvement in JIA pathogenesis is clear and the risk of recurrence among siblings supports this contribution. An important landmark of this discovery involves the acknowledgment of major histocompatibility complex (MHC) polymorphism contribution to JIA development susceptibility. Despite many advances, the numerous available studies cannot explain several implicit mechanisms in JIA pathogenesis yet. Copyright © 2012 Elsevier Editora Ltda. All rights reserved.

  14. Lipid myopathy associated with renal tubular acidosis and spastic diplegia in two brothers.

    Science.gov (United States)

    Tung, Y C; Tsau, Y K; Chu, L W; Young, C; Shen, Y Z

    2001-07-01

    Lipid myopathy is a group of disorders involving mitochondrial fatty acid oxidation. We describe two brothers, 3 years 8 months old and 2 years 9 months old, respectively, with progressive spastic diplegia, developmental delay, failure to thrive, and chronic metabolic acidosis who had lipid myopathy and renal tubular acidosis. Brain magnetic resonance imaging revealed demyelinating changes in the periventricular white matter, which was compatible with spastic diplegia. These symptoms may be related to errors in fatty acid metabolism. Cerebral palsy had been misdiagnosed in both of these patients at another hospital. Therefore, for patients with late-onset and progressive spastic diplegia, detailed investigations for underlying diseases are warranted.

  15. My Brother's Teacher? Siblings and Literacy Development in the Home

    Directory of Open Access Journals (Sweden)

    Laura Sokal

    2011-01-01

    Full Text Available Frequency of sibling literacy interactions were examined in 134 families with at least two children, where at least one of the children attended school in grade one to grade four. Parents in the majority of families reported that their children read together on a regular basis without a parent present. This held across various demographic constellations including gender of the older child. However, children from families with three or more children were less likely to read with their siblings. Implications for parents and teachers are discussed.

  16. Living kidney transplantation between brothers with unrecognized renal amyloidosis as the first manifestation of familial Mediterranean fever: a case report.

    Science.gov (United States)

    Peces, Ramón; Afonso, Sara; Peces, Carlos; Nevado, Julián; Selgas, Rafael

    2017-08-31

    Familial Mediterranean fever is an autosomal recessive disease characterized by recurrent episodes of fever and polyserositis and by the onset of reactive amyloid-associated amyloidosis. Amyloidosis due to familial Mediterranean fever can lead to end-stage renal disease, culminating in kidney transplantation for some patients. In this study, we report the clinical outcome of two brothers with familial Mediterranean fever who were the inadvertent donor and recipient, respectively, of a kidney. Subsequently, they were diagnosed with renal amyloidosis secondary to familial Mediterranean fever and were successfully treated with anakinra and colchicine. Two brothers with familial Mediterranean fever and renal amyloidosis were the inadvertent donor and recipient, respectively, of a kidney. The recipient had presented recurrent acute febrile episodes of familial Mediterranean fever, developed nephrotic syndrome secondary to amyloidosis and needed bilateral nephrectomy and chronic dialysis. His elder brother, in apparent good health, donated his left kidney to his brother. Immediately after the kidney transplantation, both the donor and recipient presented massive proteinuria, impaired renal function and elevated serum amyloid A levels. Biopsies of the brothers' kidneys showed amyloidosis. Genetic studies thereafter revealed a homozygous variant for the MEFV gene (NM_000243.2.c.2082G > A; p.M694I) in both brothers. At this point, both the donor and recipient were treated with colchicine and anakinra, resulting in improved renal function, decreased proteinuria, undetectable serum amyloid A levels and stable renal function at 62 months of follow-up and no major adverse effects. In familial Mediterranean fever, analyses of the MEFV gene should be performed in potential live kidney donors from a direct family member (either between siblings or between parents and children). In addition, genetic studies are required when consanguinity is suspected between members involved in

  17. Bernoulli Brothers

    Indian Academy of Sciences (India)

    family flourished in business, but afterwards, its descendants. Utpal Mukhopadhyay is a teacher in Barasat. Satyabharati Vidyapith,. West Bengal. The Bernoulli .... problem, experts could readily recognise that the anonymous problem solver was none other than Sir Isaac Newton (1642-. 1727) and Johann commented on it ...

  18. Birth order and ratio of brothers to sisters in Spanish transsexuals.

    Science.gov (United States)

    Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio

    2011-06-01

    Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than sisters. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism.

  19. A Song in the Dark. Francis of Assisi’s Canticle of Brother Sun

    Directory of Open Access Journals (Sweden)

    Speelman Willem Marie

    2016-10-01

    Full Text Available The Canticle of the Creatures or Canticle of Brother Sun is based on a particular way of perceiving reality. Francis, who had turned away from ‘the world’, discovered a different way of looking at it. This is a divine way of perceiving, in which the senses do not grasp reality, but accept it as it communicates itself. This way of perceiving is only possible if one does not attempt to master the environment, but allows one’s senses to be weak. It is significant, therefore, that this song of praise was born at a moment of the utmost despair and weakness. The song’s content is in line with this weak perception: it is not about Francis who praises God and (or for His creatures, but rather it is a testimony that the creatures-the elements-are already praising God, and a prayer that He should let Himself be praised by the creatures. Also in line with this weak perception is the fact that the creatures are praised just as they communicate themselves to Francis: as bodies. The theology of this song is that the creatures through their bodies resonate (strengthen, and colour the blessings that come from God, thereby making His blessing present here on earth. Francis’ role is to give a voice and a language to the heavenly praises as they resound in his environment. The transformative power of this song is that we, whether consciously or not, do the same thing when we participate in this song.

  20. Comedia del valor de las letras y las armas: New Light on the Story of Captive Captain and his Brothers (DQ 1, 37-45

    Directory of Open Access Journals (Sweden)

    Clark Colahan

    2015-12-01

    Full Text Available The tale of the captive captain, Ruy Pérez de Viedma, and his brothers, as well as Don Quixote’s discourse on arms and letters which serves as its prologue, have been well studied, but a model combining both parts of this thematic unit found in the first part of Don Quixote has not been previously identified. The anonymous late-sixteenth-century play Comedia del valor de las letras y las armas, here studied as a source for the first time, may well have been known to Cervantes and provides extensive parallels of theme and characterization to Cervantes’ treatment of both Renaissance discourse on preserving peace and the folktale of three brothers and their respective professions. It brings into sharp focus that these chapters resolve the debate between arms and letters in favor of a third element, social power and money.

  1. ATRX mutation in two adult brothers with non-specific moderate intellectual disability identified by exome sequencing.

    Science.gov (United States)

    Moncini, S; Bedeschi, M F; Castronovo, P; Crippa, M; Calvello, M; Garghentino, R R; Scuvera, G; Finelli, P; Venturin, M

    2013-12-01

    In this report, we describe two adult brothers affected by moderate non-specific intellectual disability (ID). They showed minor facial anomalies, not clearly ascribable to any specific syndromic patterns, microcephaly, brachydactyly and broad toes. Both brothers presented seizures. Karyotype, subtelomeric and FMR1 analysis were normal in both cases. We performed array-CGH analysis that revealed no copy-number variations potentially associated with ID. Subsequent exome sequence analysis allowed the identification of the ATRX c.109C>T (p.R37X) mutation in both the affected brothers. Sanger sequencing confirmed the presence of the mutation in the brothers and showed that the mother is a healthy carrier. Mutations in the ATRX gene cause the X-linked alpha thalassemia/mental retardation (ATR-X) syndrome (MIM #301040), a severe clinical condition usually associated with profound ID, facial dysmorphism and alpha thalassemia. However, the syndrome is clinically heterogeneous and some mutations, including the c.109C>T, are associated with a broad phenotypic spectrum, with patients displaying a less severe phenotype with only mild-moderate ID. In the case presented here, exome sequencing provided an effective strategy to achieve the molecular diagnosis of ATR-X syndrome, which otherwise would have been difficult to consider due to the mild non-specific phenotype and the absence of a family history with typical severe cases.

  2. Gabriel García Márquez's «Eréndira» and the Brothers Grimm

    Directory of Open Access Journals (Sweden)

    Joel Hancock

    1978-08-01

    Full Text Available García Márquez's long story «La increíble y triste historia de la Cándida Eréndira y de su abuela desalmada» is studied in the light of the structures and themes of the fairy tale, particularly of the type collected by the Grimm brothers. Dimensions of special interest are the organizational framework of the narrative, the portrayal of characters, and certain motifs, all of which are strongly reminiscent of Grimm's Fairy Tales . These elements are examined as representative of those morphologies which Vladimir Propp delineates for the genre of the fairy tale in his Morphology of the Folktale .

  3. Brothers with hypospadias, vertebral segmentation defects, and intellectual disability: new syndrome?

    Science.gov (United States)

    Phadke, Shubha R; Ranganath, Prajnya; Boggula, Vijay Raju; Gupta, Divya; Phadke, Rajendra V; Sloman, Melissa; Turnpenny, Peter D

    2012-12-01

    We report on two brothers (born to nonconsanguineous parents) with short stature, hypospadias, scoliosis, vertebral segmentation defects of "spondylocostal dysostosis" type, and intellectual disability. Results of cytogenetic and molecular genetic tests performed, including routine karyotype, MLPA (multiplex ligation-dependent probe amplification) for common microdeletions and subtelomeric copy number variants, microarray-CGH analysis, and sequencing of four Notch signaling pathway genes (DLL3, MESP2, LFNG, and HES7), were all normal. We present a comparison of the condition in the two boys with known syndromes and suggest that they may represent a hitherto unreported syndrome, most likely following autosomal recessive inheritance, though X-linked inheritance is not excluded. Copyright © 2012 Wiley Periodicals, Inc.

  4. [1896: How nascent radiotherapy gathered Roentgen, Pasteur and the Lumière brothers].

    Science.gov (United States)

    Foray, N

    2016-12-01

    On the 4th July, 1896, in his medical office of Les Échelles (Savoie, France), Victor Despeignes performed the very first radiotherapy against cancer, documented by indisputable proofs. However, the intellectual and practical approach that leads to this first radiotherapy may appear unexpected to date. Indeed, it is likely that the treatment that Despeignes applied to his neighbour, who did not suffer from stomach cancer, was born with the indirect support of the Lumière brothers, on the basis of a biological theory (the parasitory theory of cancer) that is irrelevant today, with an experimental protocol based on experiments performed on tuberculosis et in a bifractionated model linked by the constraints of a district medical doctor. Copyright © 2016 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  5. Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.

    LENUS (Irish Health Repository)

    Houlihan, Diarmaid D

    2009-08-21

    X-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment.

  6. A sterile sperm caste protects brother fertile sperm from female-mediated death in Drosophila pseudoobscura

    DEFF Research Database (Denmark)

    Holman, Luke; Snook, Rhonda R

    2008-01-01

    Spermicide (i.e., female-mediated sperm death) is an understudied but potentially widespread phenomenon that has important ramifications for the study of sexual conflict, postcopulatory sexual selection, and fertility [1, 2]. Males are predicted to evolve adaptations against spermicide, but few...... antispermicidal mechanisms have been definitively identified. One such adaptation may be the enigmatic infertile sperm morphs or "parasperm" produced by many species, which have been hypothesized to protect their fertile brother "eusperm" from spermicide [2, 3]. Here, we show that female Drosophila pseudoobscura...... reproductive tracts are spermicidal and that the survival of eusperm after exposure to the female tract is highest when males produce many parasperm. This study clarifies the adaptive significance of infertile sperm castes, which has remained elusive in Drosophila and other taxa despite much recent interest [2...

  7. [The brothers of Jumiege--the peripheral nervous system in early French mythology].

    Science.gov (United States)

    Brean, Are

    2002-03-20

    This article reviews the process of discovery of the nervous system from Pythagoras (570-500 BC) to Galen (130-201 AD). After Galen, no anatomical studies were performed before the renaissance. According to a legend, probably produced for political reasons, two brothers, sons of the French king Clovis II, revolted against their father and were sentenced to loose their physical powers by having the nerves of their arms and legs cut. They were then set adrift on the river Seine, stranding at the Jumiège monastery. The earliest written version of this legend stems from the fourteenth century; it was probably a part of the local French mythology. This indicates that the existence of the peripheral nervous system, and therefore also in part the knowledge contained in the early anatomical works, quite early may have been more or less known outside academic circles.

  8. Observations of Local Seismicity and Harmonic Tremor Using an Ocean Bottom Hydrophone Array at Brothers Volcano, South Kermadec Arc.

    Science.gov (United States)

    Haxel, J. H.; Dziak, R. P.; Lau, T. K.; Matsumoto, H.

    2005-12-01

    The submarine Brothers volcano is an important link in the volcanic chain of the southern Kermadec Arc system in the Southwest Pacific Ocean north of New Zealand. The 3-3.5 km wide caldera has a center depth of 1850m and steep surrounding walls of 300-450m. Active hydrothermal venting distinguished Brothers as a point of focus for the New Zealand American Submarine Ring of Fire (NZASRoF) expeditions in 2004 and 2005. Due to its remote location, moderate to small magnitude seismicity around the Brothers area is largely unknown. In late September 2004, four ocean bottom hydrophones (OBHs) were deployed on the caldera floor. In April 2005, three of the four instruments were recovered intact. These three OBHs continuously recorded, for seven months, the low frequency (0-110Hz) acoustic field around Brothers volcano, in particular seismic P- and S-waves propagating through the crust and acoustic T-waves in the water column . Preliminary analysis reveals seismicity rates on the order of 106 earthquakes per month. In addition to seismic arrivals, low frequency harmonic tremor is frequently and independently observed on each of the OBH instruments, often occurring subsequent to the larger seismic events. Qualitative comparisons of these signals with tremor observed from the Volcano Islands south of Japan (Dziak and Fox, 2002) show them to be nearly equivalent in frequency structure, suggesting the origin of the tremor observed at Brothers may also be attributed to resonance of a magma-gas mixture in a large chamber or conduit near the water/ seafloor boundary.

  9. Submarine hydrothermal activity and gold-rich mineralization at Brothers Volcano, Kermadec Arc, New Zealand

    Science.gov (United States)

    de Ronde, Cornel E. J.; Massoth, Gary J.; Butterfield, David A.; Christenson, Bruce W.; Ishibashi, Junichiro; Ditchburn, Robert G.; Hannington, Mark D.; Brathwaite, Robert L.; Lupton, John E.; Kamenetsky, Vadim S.; Graham, Ian J.; Zellmer, Georg F.; Dziak, Robert P.; Embley, Robert W.; Dekov, Vesselin M.; Munnik, Frank; Lahr, Janine; Evans, Leigh J.; Takai, Ken

    2011-07-01

    Brothers volcano, of the Kermadec intraoceanic arc, is host to a hydrothermal system unique among seafloor hydrothermal systems known anywhere in the world. It has two distinct vent fields, known as the NW Caldera and Cone sites, whose geology, permeability, vent fluid compositions, mineralogy, and ore-forming conditions are in stark contrast to each other. The NW Caldera site strikes for ˜600 m in a SW-NE direction with chimneys occurring over a ˜145-m depth interval, between ˜1,690 and 1,545 m. At least 100 dead and active sulfide chimney spires occur in this field and are typically 2-3 m in height, with some reaching 6-7 m. Their ages (at time of sampling) fall broadly into three groups: metal-rich, and gas-poor. Calculated end-member fluids from NW Caldera vents indicate that phase separation has occurred, with Cl values ranging from 93% to 137% of seawater values. By contrast, vent fluids at the Cone site are diffuse, noticeably cooler (≤122°C), more acidic (pH 1.9), metal-poor, and gas-rich. Higher-than-seawater values of SO4 and Mg in the Cone vent fluids show that these ions are being added to the hydrothermal fluid and are not being depleted via normal water/rock interactions. Iron oxide crusts 3 years in age cover the main cone summit and appear to have formed from Fe-rich brines. Evidence for magmatic contributions to the hydrothermal system at Brothers includes: high concentrations of dissolved CO2 (e.g., 206 mM/kg at the Cone site); high CO2/3He; negative δD and δ18OH2O for vent fluids; negative δ34S for sulfides (to -4.6‰), sulfur (to -10.2‰), and δ15N2 (to -3.5‰); vent fluid pH values to 1.9; and mineral assemblages common to high-sulfidation systems. Changing physicochemical conditions at the Brothers hydrothermal system, and especially the Cone site, occur over periods of months to hundreds of years, as shown by interlayered Cu + Au- and Zn-rich zones in chimneys, variable fluid and isotopic compositions, similar shifts in 3He/4He

  10. The two Haydns and the brothers hospitallers (Barmherzige Brüder, Fatebene frateli, Osi):The four pupils, the less known sources

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2001-01-01

    Roč. 38, 3-4 (2001), s. 333-342 ISSN 0018-7003 Institutional research plan: CEZ:AV0Z8059909 Keywords : brothers hospitallers, J and M. Haydn, pupils Subject RIV: AL - Art, Architecture, Cultural Heritage

  11. Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype

    OpenAIRE

    Skauli, Nadia; Wallace, Sean; Chiang, Samuel C. C.; Bar?y, Tuva; Holmgren, Asbj?rn; Stray-Pedersen, Asbj?rg; Bryceson, Yenan T.; Str?mme, Petter; Frengen, Eirik; Misceo, Doriana

    2016-01-01

    Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmorphisms, and skeletal, ophthalmological, cardiac, and genitourinary abnormalities. We report a novel homozygous PIGT missense variant c.1079G>T (p.Gly360Val) in two brothers w...

  12. Megacystis-microcolon-intestinal hypoperistalsis syndrome in a newborn girl whose brother had prune belly syndrome: common pathogenesis?

    Science.gov (United States)

    Oliveira, G; Boechat, M I; Ferreira, M A

    1983-01-01

    A case of megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is presented. There were important findings: a urachal remnant and a brother with prune belly syndrome (PBS). After a review of the literature, many common characteristics of MMIHS and PBS are described: flaccid abdomen, dilatation of the urinary tract, intestinal malrotation, cryptorchidism, urachal remnants and familial incidence. MMIHS and PBS may be manifestations of the same underlying process.

  13. Megacystis-microlon-intestinal hypoperistalsis syndrome in a newborn girl whose brother had Prune Belly syndrome: Common Pathogenesis

    International Nuclear Information System (INIS)

    Oliveira, G.; Boechat, M.I.; Fereira, M.A.

    1983-01-01

    A case of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS) is presented. There were important findings: a urachal remnant and a brother with Prune Belly Syndrome (PBS). After a review of the literature, many common characteristics of MMIHS and PBS are described: flaccid abdomen, dilatation of the urinary tract, intestinal malrotation, cryptorchidism, urachal remnants and familial incidence. MMIHS and PBS may be manifestations of the same underlying process. (orig.)

  14. Megacystis-microlon-intestinal hypoperistalsis syndrome in a newborn girl whose brother had Prune Belly syndrome: Common Pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, G.; Boechat, M.I.; Fereira, M.A.

    1983-07-01

    A case of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS) is presented. There were important findings: a urachal remnant and a brother with Prune Belly Syndrome (PBS). After a review of the literature, many common characteristics of MMIHS and PBS are described: flaccid abdomen, dilatation of the urinary tract, intestinal malrotation, cryptorchidism, urachal remnants and familial incidence. MMIHS and PBS may be manifestations of the same underlying process.

  15. Challenging stereotypes? The older woman in the TV series Brothers & Sisters.

    Science.gov (United States)

    Oró-Piqueras, Maricel

    2014-12-01

    The TV series, Brothers & Sisters, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. [Cancer of the oral cavity in three brothers of the whole blood in Mauritania].

    Science.gov (United States)

    Baba, Nacer Dine

    2016-01-01

    Major risk factors for cancers of the oral cavity are alcohol and tobacco, but hereditary factors were also identified. This case study aims to illustrate this last component among the most known risk factors. We here report three cases of brothers of the whole blood presenting with cancer of the oral cavity showing rapid development in less than a year in each of them. Additional risk factors other than hereditary factors were: smoking, poor oral hygiene, low fruit and vegetable intake. Hereditary risk has been a controversial issue for a long period of time, but several recent studies have suggested the existence of this risk factor which is consistent with our observation. These studies even showed that hereditary component for carcinomas of the upper aerodigestive tract seems likely; it is important that family members at risk understand that their vulnerability to these tumors can be greatly reduced by stopping smoking, by a moderate consumption of alcohol and a frequent consumption of raw fruits and vegetables. Further studies should be carried out in our country to clarify the respective role of these different risk factors in developing this type of cancer Meanwhile, prevention and early diagnosis are the most appropriate means to fight against this type of cancer.

  17. [Fragile X syndrome and white matter abnormalities: Case study of two brothers].

    Science.gov (United States)

    Wallach, E; Bieth, E; Sevely, A; Cances, C

    2017-03-01

    Fragile X syndrome is the most usual cause of hereditary intellectual deficiency. Typical symptoms combine intellectual deficiency, social anxiety, intense emotional vigilance, and a characteristic facial dysmorphy. This is subsequent to a complete mutation of the FMR1 gene, considering a semidominant transmission linked to the unstable X. The expansion of the CGG triplet greater than 200 units combined with a high methylation pattern lead to a transcriptional silence of the FMR1 gene, and the protein product, the FMRP, is not synthesized. This protein is involved in synaptic plasticity. Brain MRI can show an increased volume of the caudate nucleus and hippocampus, combined with hypoplasia of the cerebellar vermis. Fragile X Associated Tremor Ataxia Syndrome (FXTAS) syndrome is a neurodegenerative disorder occurring in carriers of the premutation in FMR1. Brain MRI shows an increased T2 signal in the middle cerebellar peduncles. This syndrome is linked to a premutation in the FMR1 gene. We report here the case of two brothers presenting a typical fragile X symptomatology. Brain MRI showed hyperintensities of the middle cerebellar peduncles. Such MRI findings support the assumption of a genetic mosaicism. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  18. Super Mario brothers and sisters: Associations between coplaying video games and sibling conflict and affection.

    Science.gov (United States)

    Coyne, Sarah M; Jensen, Alexander C; Smith, Nathan J; Erickson, Daniel H

    2016-02-01

    Video games can be played in many different contexts. This study examined associations between coplaying video games between siblings and levels of affection and conflict in the relationship. Participants were 508 adolescents (M age = 16.31 years of age, SD = 1.08) who completed questionnaires on video game use and sibling relationships. Participants were recruited from a large Northwestern city and a moderate city in the Mountain West of the United States. Video games played between siblings were coded by an independent sample to assess levels of physical aggression and prosocial behavior in each game. Playing video games with a sibling was associated with higher levels of sibling affection for both boys and girls, but higher levels of conflict for boys only. Playing a violent video game with a brother was associated with lower levels of conflict in the sibling relationship, whereas playing a prosocial video game was not related to any sibling outcome. The value of video games in sibling relationships will be discussed, with a focus on the type of game and the sex of the adolescent. Copyright © 2015 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  19. Sixty Days Remaining, Forty Years of CERN, Two Brothers, One Exclusive Interview

    CERN Multimedia

    2001-01-01

    Twins Marcel and Daniel Genolin while sharing memories of their CERN experiences, point out just how much smaller the Meyrin site once was. In a place such as CERN where the physical sciences are in many ways the essence of our daily lives and where technological advancement is an everyday occurrence, it is easy to lose track of the days, months, and even years. But last week twin brothers, Daniel and Marcel Genolin, hired in the early sixties and getting ready to end their eventful forty year CERN experiences, made it clear that the winds of time bluster past us whether we are aware or not. 'CERN was very small when we started' says Marcel, who has worked in transport during his entire time here. A lot has changed. 'When I got here there were no phones in peoples' houses' he recalls,'when there were problems in the control room with the PS (Proton Synchrotron) they used to get a megaphone and tell us {the transport service} to go and get the necessary physicists from their homes in the area. We had to lo...

  20. « Nous sommes tous frères ». Les valeurs des Elephants de Brother, club de baseball professionnel à Taiwan “We are all Brothers”. The Values of Brother Elephants, professional baseball club in Taiwan

    Directory of Open Access Journals (Sweden)

    Jérôme Soldani

    2013-06-01

    Full Text Available À Taiwan, où le baseball est considéré comme le « sport national », les équipes professionnelles sont la propriété de grandes firmes locales et ne sont pas formellement attachées à une municipalité. Ce sont elles-mêmes de petites entreprises qui proposent, en archétype de société, un mode de fonctionnement interne qui repose sur des valeurs autour desquelles se fédèrent leurs supporters. Basée sur une enquête ethnographique de douze mois, notamment au sein de la formation professionnelle des Elephants de Brother, cette contribution montrera comment celle-ci se donne à voir comme une entreprise structurée autour de valeurs morales entendues comme « traditionnelles » et dont les joueurs de l’équipe sont érigés en parangons. Le modèle d’une famille unie et strictement hiérarchisée est mis en exergue par les propriétaires du club et son iconographie. Mais ces représentations se heurtent à la réalité de la pratique quotidienne et aux affaires de corruption qui sapent régulièrement l’image de la ligue professionnelle taiwanaise.In Taiwan, where baseball is considered as the national sport, professional teams are owned by large local firms and are not formally attached to a municipality. They are themselves small companies offering an archetypal society, whose mode of internal operations are based on values around which to unite their fans. Based on an ethnographic study of twelve months, particularly among the professional team of Brother Elephants, this contribution will show how it is to be seen as an enterprise structured around moral values understood as traditional and whose players are established as paragons. The model of a united family and strictly hierarchical is highlighted by the owners of the club and its iconography. But these representations are faced with the reality of daily practice and corruption that regularly undermine the image of the Taiwanese professional league.

  1. Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling.

    Directory of Open Access Journals (Sweden)

    Javier A Tello

    Full Text Available Congenital hypogonadotropic hypogonadism (CHH is characterized by low gonadotropins and failure to progress normally through puberty. Mutations in the gene encoding the GnRH receptor (GNRHR1 result in CHH when present as compound heterozygous or homozygous inactivating mutations. This study identifies and characterizes the properties of two novel GNRHR1 mutations in a family in which three brothers display normosmic CHH while their sister was unaffected. Molecular analysis in the proband and the affected brothers revealed two novel non-synonymous missense GNRHR1 mutations, present in a compound heterozygous state, whereas their unaffected parents possessed only one inactivating mutation, demonstrating the autosomal recessive transmission in this kindred and excluding X-linked inheritance equivocally suggested by the initial pedigree analysis. The first mutation at c.845 C>G introduces an Arg substitution for the conserved Pro 282 in transmembrane domain (TMD 6. The Pro282Arg mutant is unable to bind radiolabeled GnRH analogue. As this conserved residue is important in receptor conformation, it is likely that the mutation perturbs the binding pocket and affects trafficking to the cell surface. The second mutation at c.968 A>G introduces a Cys substitution for Tyr 323 in the functionally crucial N/DPxxY motif in TMD 7. The Tyr323Cys mutant has an increased GnRH binding affinity but reduced receptor expression at the plasma membrane and impaired G protein-coupling. Inositol phosphate accumulation assays demonstrated absent and impaired Gα(q/11 signal transduction by Pro282Arg and Tyr323Cys mutants, respectively. Pretreatment with the membrane permeant GnRHR antagonist NBI-42902, which rescues cell surface expression of many GNRHR1 mutants, significantly increased the levels of radioligand binding and intracellular signaling of the Tyr323Cys mutant but not Pro282Arg. Immunocytochemistry confirmed that both mutants are present on the cell membrane

  2. A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections

    Directory of Open Access Journals (Sweden)

    Xu Xiu

    2012-08-01

    Full Text Available Abstract Background Autistic spectrum disorders (ASDs are a family of neurodevelopmental disorders with strong genetic components. Recent studies have shown that copy number variations in dosage sensitive genes can contribute significantly to these disorders. One such gene is the transcription factor MECP2, whose loss of function in females results in Rett syndrome, while its duplication in males results in developmental delay and autism. Case presentation Here, we identified a Chinese family with two brothers both inheriting a 2.2 Mb MECP2-containing duplication (151,369,305 – 153,589,577 from their mother. In addition, both brothers also had a 213.7 kb duplication on Chromosome 2, inherited from their father. The older brother also carried a 48.4 kb duplication on Chromosome 2 inherited from the mother, and a 8.2 kb deletion at 11q13.5 inherited from the father. Based on the published literature, MECP2 is the most autism-associated gene among the identified CNVs. Consistently, the boys displayed clinical features in common with other patients carrying MECP2 duplications, including intellectual disability, autism, lack of speech, slight hypotonia and unsteadiness of movement. They also had slight dysmorphic features including a depressed nose bridge, large ears and midface hypoplasia. Interestingly, they did not exhibit other clinical features commonly observed in American-European patients with MECP2 duplication, including recurrent respiratory infections and epilepsy. Conclusions To our knowledge, this is the first identification and characterization of Chinese Han patients with MECP2-containing duplications. Further cases are required to determine if the above described clinical differences are due to individual variations or related to the genetic background of the patients.

  3. Hasil Rancang Bangun Sistem ERP dengan SDLC Model Waterfall: Studi Kasus Sistem Inventori PT Pan Brothers, Tbk.

    Directory of Open Access Journals (Sweden)

    Harijanto Pangestu

    2012-12-01

    Full Text Available Competition in the business world effects the use of information technology. To achieve competitive advantage in the global competition, PT Pan Brothers, Tbk. should establish an integrated information system based on ERP (Enterprise Resource Planning. With the ERP system, information will be accurate and up-todate to support strategic decision making. It takes conscientious planning in building the ERP system. Management information systems development projects have a very important role. One determining component is how to choose and use appropriate information systems development method. SDLC (system development life cycle is growing very rapidly along with the development of information technology. It is necessary to choose the right SDLC in building an integrated system based on ERP. Each SDLC models has advantages and disadvantages. SDLC models will only be optimal if used according to the situation and conditions. Waterfall model provides clear deliverables and milestones, good documentation, easy to understand, easy to implement, emphasizes on good procedural workmanship (precoding design. Some of its weaknesses are difficult to integrate risk management, high cost change documents, high administrative costs, often late completion thus.To avoid them, there should be a well-planned project management and steps properly so it can be on time and will not exceed budget.

  4. A tragédia da impossibilidade do evento: Os Maias; o Big Brother e a pedagogia dos media

    Directory of Open Access Journals (Sweden)

    Orlando Grossegesse

    2010-01-01

    Full Text Available O romance Os Maias (1888 de Eça de Queiroz pertence ao cânone da Literatura Portuguesa. Questionando a leitura integral de textos literários no Ensino Secundário, a definição de Os Maias no sistema sócio-comunicativo da época como romance de conversação leva à descoberta do seu carácter dilemático numa sociedade dos média. No cerne desta abordagem está uma reinterpretação do incesto, evento que irrompe na vida social da alta sociedade lisboeta representada no romance. Esta representação é comparada ao Big Brother, levando a uma crítica da cultura que também diz respeito à actualidade. The novel Os Maias (1888, by Eça de Queiroz, belongs to the canons of Portuguese literature. Questioning the integral reading of literary texts in secondary school education, the definition of Os Maias in the sociocommunicative system of the time as a conversation novel highlights its dilemma in the media society. At the bottom of this approach lies the reinterpretation of incest, an event that bursts into the social life of Lisbon high society represented in the novel. This representation is compared with “Big Brother”, leading to a critique of culture that is also related to current times.

  5. Legal consequences for torture in children cases: the Gomez Paquiyauri Brothers vs Peru case.

    Science.gov (United States)

    Tinta, Monica Feria

    2009-01-01

    The Gomez Paquiyauri Brothers case, before the Inter-American Court of Human Rights, was the first international case concerning the protection of children in the context of armed conflict where an international court stated the law concerning the duties of States towards children even in the context of war, and provided for reparations. As such it represents a landmark decision. The case arose from the illegal detention, torture and extrajudicial execution of two minors, Emilio and Rafael Gomez Paquiyauri, at the hands of Peruvian Police in 1991, under the Fujimori Administration at a time when the internal war in Peru was at its peak. Unlike most cases coming to the jurisdiction of the Inter-American Court, the case had been subject to domestic criminal investigations that had led to the convictions of two low ranking policemen. Yet a more subtle pattern of impunity lied at the root of the case. Torture had been denied by the State, and the prosecutions of low ranking policemen had intended to cover up the responsibility of those who ordered a policy of torture and executions (including the existence of secret codes for the torture and elimination of suspects of "terrorism") during the years of the internal armed conflict in Peru. The joint work of legal and medical expertise in the litigation of the case permitted the establishment of the facts and the law, obtaining an award of 740,500 dollars for the victims and a number of measures of reparation including guarantees of non-repetition and satisfaction, such as the naming of a school after the victims.

  6. Brown and polar bear Y chromosomes reveal extensive male-biased gene flow within brother lineages.

    Science.gov (United States)

    Bidon, Tobias; Janke, Axel; Fain, Steven R; Eiken, Hans Geir; Hagen, Snorre B; Saarma, Urmas; Hallström, Björn M; Lecomte, Nicolas; Hailer, Frank

    2014-06-01

    Brown and polar bears have become prominent examples in phylogeography, but previous phylogeographic studies relied largely on maternally inherited mitochondrial DNA (mtDNA) or were geographically restricted. The male-specific Y chromosome, a natural counterpart to mtDNA, has remained underexplored. Although this paternally inherited chromosome is indispensable for comprehensive analyses of phylogeographic patterns, technical difficulties and low variability have hampered its application in most mammals. We developed 13 novel Y-chromosomal sequence and microsatellite markers from the polar bear genome and screened these in a broad geographic sample of 130 brown and polar bears. We also analyzed a 390-kb-long Y-chromosomal scaffold using sequencing data from published male ursine genomes. Y chromosome evidence support the emerging understanding that brown and polar bears started to diverge no later than the Middle Pleistocene. Contrary to mtDNA patterns, we found 1) brown and polar bears to be reciprocally monophyletic sister (or rather brother) lineages, without signals of introgression, 2) male-biased gene flow across continents and on phylogeographic time scales, and 3) male dispersal that links the Alaskan ABC islands population to mainland brown bears. Due to female philopatry, mtDNA provides a highly structured estimate of population differentiation, while male-biased gene flow is a homogenizing force for nuclear genetic variation. Our findings highlight the importance of analyzing both maternally and paternally inherited loci for a comprehensive view of phylogeographic history, and that mtDNA-based phylogeographic studies of many mammals should be reevaluated. Recent advances in sequencing technology render the analysis of Y-chromosomal variation feasible, even in nonmodel organisms. © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e

  7. A Clarion Call for Social Work Attention: Brothers and Sisters of Persons With Acquired Brain Injury in the United States.

    Science.gov (United States)

    Degeneffe, Charles Edmund

    2016-08-11

    This article presents a clarion call for increased social work attention to the needs of siblings of persons with acquired brain injury (ABI) in the United States. The article overviews how siblings are psychosocially affected, how they provide care to the injured brothers and sisters, and how they personally develop as a result of their experiences. The article highlights the fact that social workers and other professionals often overlook the needs of siblings of persons with ABI and makes an appeal for social workers to advance clinical practice and research to benefit this often neglected population.

  8. Race and the refusal to name racism: consumption, identity and choice in the Celebrity Big Brother House

    OpenAIRE

    Thomas, Dania

    2009-01-01

    The centrality of consumption in the resolution of the ‘race row’ in the Celebrity Big Brother(CBB) House 2007 characterizes ‘the consumption politics of race’ engendered in response to ‘racism lite’ (adopting Mary Riddell’s term) - forms of racial harm articulated in normative frames specific to the entertainment industry. The regulatory response to racism litewas premised on a radical and post-modern framing of race and racial harm. When compared with the responses to racism outside the CBB...

  9. Structures, stability, mechanical and electronic properties of a-boron and its twined brother a*-boron

    OpenAIRE

    He, Chaoyu; Zhong, Jianxin

    2013-01-01

    The structures, stability, mechanical and electronic properties of a-boron and its twined brother a*-boron have been studied by first-principles calculations. Both a-boron and a*-boron consist of equivalent icosahedra B12 clusters in different connecting configurations of "3S-6D-3S" and "2S-6D-4S", respectively. The total energy calculations show that a*-boron is less stable than a-boron but more favorable than beta-boron and Gamma-boron at zero pressure. Both a-boron and a*-boron are confirm...

  10. Culture-independent characterization of a novel microbial community at a hydrothermal vent at Brothers volcano, Kermadec arc, New Zealand

    Science.gov (United States)

    Stott, M. B.; Saito, J. A.; Crowe, M. A.; Dunfield, P. F.; Hou, S.; Nakasone, E.; Daughney, C. J.; Smirnova, A. V.; Mountain, B. W.; Takai, K.; Alam, M.

    2008-08-01

    The bacterial and archaeal diversity of a hydrothermal vent microbial community at Brothers volcano situated in the Kermadec arc, ˜400 km off the north coast of New Zealand, was examined using culture-independent molecular analysis. An unusual microbial community was detected with only 1% and 40% of the bacterial phylotypes exhibiting >92% small subunit (SSU) rRNA gene sequence similarity with cultivated and noncultivated microbes, respectively. Of the 29 bacterial representative phylotypes, over one third of the SSU rRNA gene sequences retrieved belonged to uncultivated candidate divisions including OP1, OP3, OP5, OP8, OD1, and OP11. All archaeal phylotypes belonged to the phylum Euryarchaeota in the uncultivated groups deep hydrothermal vent euryarchaeotal (DHVE) I and II or to the phylum Korarchaeota. Like the bacterial clone library, only a small proportion of archaeal SSU rRNA gene sequences (˜2% and 20%) displayed >92% sequence identity with any archaeal isolates or noncultivated microbes, respectively. Although the bacterial phylotypes detected were phylogenetically most similar to microbial communities detected in methane, hydrocarbon, and carbon dioxide-based hydrothermal and seep environments, no phylotypes directly associated with anaerobic methane oxidation and mcrA activity could be detected. The geochemical composition of the vent fluids at the Brothers-lower cone sample site is unusual and we suggest that it may play a prominent role in the species selection of this microbial community.

  11. Different types of glomerulonephritis associated with the dysregulation of the complement alternative pathway in 2 brothers: A case report.

    Science.gov (United States)

    Chen, Pei; Zhu, Li; Yu, Feng; Han, Sha-Sha; Meng, Si-Jun; Guo, Wei-Yi; Zhang, Hong; Song, Yan

    2017-06-01

    C3 glomerulonephritis (C3GN) and complement-mediated hemolytic uremic syndrome (HUS) both result from the abnormal regulation of the complement system. A significant number of patients with C3GN or complement-mediated HUS have mutations of more than 1 complement protein. This discovery has had a major impact on identifying the underlying cause of familial C3GN or complement-mediated HUS. We report the cases of 2 brothers (herein referred to as patient II-1 and patient II-9), both with complement disorders that differed in their clinical and genetic features. Patient II-1 clinically presented with nephrotic syndrome and acute kidney injury and pathologically presented with C3GN combined with thrombotic microangiopathy (TMA) and subacute tubulointerstitial nephritis. Meanwhile, patient II-9 clinically presented with HUS and pathologically presented with TMA combined with acute severe tubular injury. Screenings for genetic mutations contributed to complement system dysregulation were performed on patient II-1. The genome sequencing identified that patient II-1 had a heterozygous mutation in the C3 gene (c.C1774T/p.R592W). Nine other relatives of the brothers were checked for this C3 mutation and only the daughter of patient II-1 (herein referred to as patient III-2) carried it, but so far, she does not have any clinical manifestations of kidney disease. Family members with a dysregulation of the complement alternative pathway may differ in its clinical and genetic features.

  12. Palmo-Plantar hyperkeratosis, intellectual disability, and spastic paraplegia in two maternal half brothers: further evidence for an X-linked inheritance.

    Science.gov (United States)

    Isidor, Bertrand; Lefebvre, Tiphaine; Barbarot, Sébastien; Perrier, Julie; Mercier, Sandra; Péréon, Yann; Le Caignec, Cédric; David, Albert

    2013-06-01

    In 1983, Fitzsimmons et al. reported four brothers with an unrecognized disorder characterized by intellectual disability, spastic paraplegia, and palmo-plantar hyperkeratosis (OMIM 309500). In this report, we describe a family in which two males, maternal half-brothers, had learning disabilities. Both patients also showed spasticity in the lower limbs and palmo-plantar hyperkeratosis. The mother of the affected boys had learning difficulties but did not show any dermatological symptoms. This report confirms that the association of features reported by Fitzsimmons et al. is a distinct entity and further suggests an X-linked mode of inheritance. Copyright © 2013 Wiley Periodicals, Inc.

  13. Cerebrotendinous xanthomatosis: report of two Brazilian brothers Xantomatose cerebrotendínea: relato de dois irmãos brasileiros

    Directory of Open Access Journals (Sweden)

    Marcos Christiano Lange

    2004-12-01

    Full Text Available Cerebrotendinous xanthomatosis is a treatable rare autossomal recessive disease characterized by lipid storage secondary to a sterol 27-hydroxylase deficiency in the formation of cholic and chenodeoxycholic acids. We describe two Brazilian brothers with cognitive impairement and chronic diarrhea. One of them also presents bilateral cataracts. Neurological findings were progressive walking deficit, limb ataxia and pyramidal signs. Both patients had bilateral Achilles tendon xanthomata. Magnetic resonance image showed signal alterations in cerebellar hemispheres. We describe these cases with molecular genetic analysis confirming diagnosis and comparing with previous literature. The CYP27A1 gene study showed a C1187T mutation on exon 6.Xantomatose cerebrotendínea é doença autossômica recessiva tratável causada pelo acúmulo de lipídeos por deficiência da enzima 27-esterol hidroxilase na produção de ácido cólico e deoxicólico. Descrevemos dois irmãos brasileiros com dificuldade cognitiva e diarréia crônica. Um deles apresentava catarata bilateral. Os achados neurológicos foram dificuldade progressiva para deambular, ataxia de membros e sinais piramidais. Ambos tinham xantomas de tendão aquileu bilateralmente. O exame de ressonância magnética revelou áreas de sinal hiperintenso em ambos os hemisférios cerebelares. Descrevemos os casos com diagnóstico genético comparando-os com a literatura. O estudo do gene CYP27A1 demonstrou a mutação C1183T no exon 6.

  14. "I like that He Always Shows Who He Is": The Perceptions and Experiences of Siblings with a Brother with Autism Spectrum Disorder

    Science.gov (United States)

    Petalas, Michael A.; Hastings, Richard P.; Nash, Susie; Dowey, Alan; Reilly, Deirdre

    2009-01-01

    Semi-structured interviews were used to explore the perceptions and experiences of eight typically developing siblings in middle childhood who had a brother with autism spectrum disorder (ASD). The interviews were analysed using interpretative phenomenological analysis (IPA). The analysis yielded five main themes: (i) siblings' perceptions of the…

  15. "My Brother Likes Meeting New People, but Don't Ask Him Any Direct Questions": Involving Adults with Autism plus Learning Disability in a Qualitative Research Project

    Science.gov (United States)

    Tozer, Rosemary; Atkin, Karl; Wenham, Aniela

    2014-01-01

    Adult siblings of people with autism and a learning disability have hitherto been largely overlooked by research, policy and practice in the UK. As part of a qualitative study focussing on adult siblings, we met twelve people with autism plus severe learning disability with their brother or sister. Individually tailored resources were used to make…

  16. Adolescent Siblings of Individuals with and without Intellectual and Developmental Disabilities: Self-Reported Empathy and Feelings about Their Brothers and Sisters

    Science.gov (United States)

    Shivers, Carolyn M.; Dykens, Elisabeth M.

    2017-01-01

    Siblings of brothers or sisters with intellectual and developmental disabilities (IDD) are important but understudied family members. As many previous studies have relied on parent report of sibling outcomes, the use of sibling self-report is an important addition to the research. This study assessed the feelings of adolescent siblings toward…

  17. Surgical Treatment for Epstein-Barr Virus Otomastoiditis Complicated by Facial Nerve Paralysis: A Case Report of Two Young Brothers and Review of Literature

    NARCIS (Netherlands)

    Eeten, E. van; Faber, H.T.; Kunst, D.

    2017-01-01

    We report the case of two young brothers with Epstein-Barr virus (EBV) otomastoiditis complicated by a facial nerve paralysis. The boys, aged 7 months (patient A) and 2 years and 8 months (patient B), were diagnosed with a facial nerve paralysis House-Brackmann (HB) grade IV (A) and V (B). After

  18. 'A Strange Mixture of Caring and Corruption': Residential Care in Christian Brothers Orphanages and Industrial Schools during Their Last Phase, 1940s to 1960s.

    Science.gov (United States)

    Coldrey, Barry

    2000-01-01

    Explores the two Christian Brothers religious orders of the Roman Catholic Church. Focuses on the Irish Congregation that has been controversial, specifically in its residential care for neglected, orphaned, and delinquent children. States that allegations of physical, sexual, and emotional abuse has been reported in their institutions. (CMK)

  19. Samuel Alderman Lomas (1838-1901) the man with two gravestones, his brother Muscot Atkin Lomas (1840-1907) and their lives in Victorian asylums.

    Science.gov (United States)

    Hilton, Claire; Hilton, Benjamin

    2009-05-01

    Samuel Alderman Lomas died in the Hertfordshire County Asylum, Hill End, St Albans in 1901. He was buried in the asylum cemetery where two gravestones bear his name. This paper traces his life history and that of his brother Muscot Atkin Lomas. Both were classed as idiots in Victorian society and spent most of their lives -- from childhood until death -- in asylums.

  20. The paths of salvation and eternal condemnation: The presence of the allegory in the History of the Elected Pilgrim and his Brother Precito (1682, de Alexandre de Gusmão

    Directory of Open Access Journals (Sweden)

    José Adriano Filho

    2015-04-01

    Full Text Available The repercussions of the echoes of the Council of Trent (1546-1563, the Counter Reform movement, and the repercussions they had on the artistic production in the Catholic world. The pedagogical-didactic intents behind its composition are grounded on the belief that art could be an effective tool for reconverting of the faithful and for indoctrination in the values of the Catholic faith. Considering that, this paper aims at presenting the way allegory became an important tool for the interpretation and construction of religious discourse, as we can see in the History of the Elected Pilgrim and his Brother Precito. The book is an allegorical narrative that presents the history of two pilgrim brothers born in Egypt from where they set out with the intention of making a fortune (one brother goes to Jerusalem, and the  other one goes to Babylon. In this way, the book presents continuity with the medieval pattern that highlights the journey, especially the path for salvation. The readiness of allegory to transmit abstract concepts through concrete visualizations allied to a form of indirect expression made it a powerful, didactic, apologetic, and entertaining tool for that time.

  1. Information dissipation as an early-warning signal for the Lehman Brothers collapse in financial time series

    Science.gov (United States)

    Quax, Rick; Kandhai, Drona; Sloot, Peter M. A.

    2013-05-01

    In financial markets, participants locally optimize their profit which can result in a globally unstable state leading to a catastrophic change. The largest crash in the past decades is the bankruptcy of Lehman Brothers which was followed by a trust-based crisis between banks due to high-risk trading in complex products. We introduce information dissipation length (IDL) as a leading indicator of global instability of dynamical systems based on the transmission of Shannon information, and apply it to the time series of USD and EUR interest rate swaps (IRS). We find in both markets that the IDL steadily increases toward the bankruptcy, then peaks at the time of bankruptcy, and decreases afterwards. Previously introduced indicators such as `critical slowing down' do not provide a clear leading indicator. Our results suggest that the IDL may be used as an early-warning signal for critical transitions even in the absence of a predictive model.

  2. Recurrent episodes of myoglobinuria, mental retardation and seizures but no hemolysis in two brothers with phosphoglycerate kinase deficiency.

    Science.gov (United States)

    Coppens, Sandra; Koralkova, Pavla; Aeby, Alec; Mojzikova, Renata; Deconinck, Nicolas; Kadhim, Hazim; van Wijk, Richard

    2016-03-01

    We report two brothers with mild intellectual deficiency, exercise intolerance, rhabdomyolysis, seizures and no hemolysis. Phosphoglycerate kinase (PGK) activity was strongly decreased in their red blood cells. Subsequent molecular analysis of PGK1 revealed hemizygosity for a novel mutation c.756 + 3A > G, in intron 7. Analysis of the effect of this mutation on pre-mRNA processing demonstrated markedly decreased levels of normal PGK1 mRNA. In addition, the c.756 + 3A > G change resulted in abnormally spliced transcripts. If translated, these transcripts mostly encode for C-terminally truncated proteins. The consequences of the c.756 + 3A > G mutation is discussed, as well as the genotype-to-phenotype correlation with regard to previously described mutations (PGK Fukuroi and PGK Antwerp), which also result in C-terminal truncated proteins. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins

    DEFF Research Database (Denmark)

    Osler, Merete; Christensen, Gunhild T.; Garde, Ellen

    2017-01-01

    INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins. METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association...... between cognitive ability from draft board examination and dementia was examined using Cox regression. RESULTS: During a 44-year follow-up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability...... was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95% confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95% CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95% CI = 1...

  4. A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty

    DEFF Research Database (Denmark)

    Känsäkoski, Johanna; Raivio, Taneli; Juul, Anders

    2015-01-01

    BACKGROUND: Idiopathic central precocious puberty (ICPP) results from the premature reactivation of the hypothalamic-pituitary-gonadal axis leading to development of secondary sexual characteristics prior to 8 y in girls or 9 y in boys. Since the initial discovery of mutations in the maternally...... imprinted MKRN3 gene in 2013, several case reports have described mutations in this gene in ICPP patients from different populations, highlighting the importance of MKRN3 as a regulator of pubertal onset. METHODS: We screened 29 Danish girls with ICPP for mutations in MKRN3. Expression of MKRN3 in human...... hypothalamic complementary DNA (cDNA) was investigated by PCR. RESULTS: One paternally inherited rare variant, c.1034G>A (p.Arg345His), was identified in one girl with ICPP and in her brother with early puberty. The variant is predicted to be deleterious by three different in silico prediction programs...

  5. brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish

    Science.gov (United States)

    Bergeron, Sadie A.; Tyurina, Oksana V.; Miller, Emily; Bagas, Andrea; Karlstrom, Rolf O.

    2011-01-01

    The transmembrane protein Brother of Cdo (Boc) has been implicated in Shh-mediated commissural axon guidance, and can both positively and negatively regulate Hedgehog (Hh) target gene transcription, however, little is known about in vivo requirements for Boc during vertebrate embryogenesis. The zebrafish umleitung (umlty54) mutant was identified by defects in retinotectal axon projections. Here, we show that the uml locus encodes Boc and that Boc function is cell-autonomously required for Hh-mediated neural patterning. Our phenotypic analysis suggests that Boc is required as a positive regulator of Hh signaling in the spinal cord, hypothalamus, pituitary, somites and upper jaw, but that Boc might negatively regulate Hh signals in the lower jaw. This study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis. PMID:21115611

  6. A novel AVPR2 splice site mutation leads to partial X-linked nephrogenic diabetes insipidus in two brothers.

    Science.gov (United States)

    Schernthaner-Reiter, Marie Helene; Adams, David; Trivellin, Giampaolo; Ramnitz, Mary Scott; Raygada, Margarita; Golas, Gretchen; Faucz, Fabio R; Nilsson, Ola; Nella, Aikaterini A; Dileepan, Kavitha; Lodish, Maya; Lee, Paul; Tifft, Cynthia; Markello, Thomas; Gahl, William; Stratakis, Constantine A

    2016-05-01

    X-linked nephrogenic diabetes insipidus (NDI, OMIM#304800) is caused by mutations in the arginine vasopressin (AVP, OMIM*192340) receptor type 2 (AVPR2, OMIM*300538) gene. A 20-month-old boy and his 8-year-old brother presented with polyuria, polydipsia, and failure to thrive. Both boys demonstrated partial DDAVP (1-desamino-8-D AVP or desmopressin) responses; thus, NDI diagnosis was delayed. While routine sequencing of AVPR2 showed a potential splice site variant, it was not until exome sequencing confirmed the AVPR2 splice site variant and did not reveal any more likely candidates that the patients' diagnosis was made and proper treatment was instituted. Both patients were hemizygous for two AVPR2 variants predicted in silico to affect AVPR2 messenger RNA (mRNA) splicing. A minigene assay revealed that the novel AVPR2 c.276A>G mutation creates a novel splice acceptor site leading to 5' truncation of AVPR2 exon 2 in HEK293 human kidney cells. Both patients have been treated with high-dose DDAVP with a remarkable improvement of their symptoms and accelerated linear growth and weight gain. We present here a unique case of partial X-linked NDI due to an AVPR2 splice site mutation; patients with diabetes insipidus of unknown etiology may harbor splice site mutations that are initially underestimated in their pathogenicity on sequence analysis. • X-linked nephrogenic diabetes insipidus is caused by AVPR2 mutations, and disease severity can vary depending on the functional effect of the mutation. What is New: • We demonstrate here that a splice site mutation in AVPR2 leads to partial X-linked NDI in two brothers. • Treatment with high-dose DDAVP led to improvement of polyuria and polydipsia, weight gain, and growth.

  7. Observer variation in target volume delineation of lung cancer related to radiation oncologist-computer interaction: A 'Big Brother' evaluation

    International Nuclear Information System (INIS)

    Steenbakkers, Roel J.H.M.; Duppen, Joop C.; Fitton, Isabelle; Deurloo, Kirsten E.I.; Zijp, Lambert; Uitterhoeve, Apollonia L.J.; Rodrigus, Patrick T.R.; Kramer, Gijsbert W.P.; Bussink, Johan; Jaeger, Katrien De; Belderbos, Jose S.A.; Hart, Augustinus A.M.; Nowak, Peter J.C.M.; Herk, Marcel van; Rasch, Coen R.N.

    2005-01-01

    Background and purpose: To evaluate the process of target volume delineation in lung cancer for optimization of imaging, delineation protocol and delineation software. Patients and methods: Eleven radiation oncologists (observers) from five different institutions delineated the Gross Tumor Volume (GTV) including positive lymph nodes of 22 lung cancer patients (stages I-IIIB) on CT only. All radiation oncologist-computer interactions were recorded with a tool called 'Big Brother'. For each radiation oncologist and patient the following issues were analyzed: delineation time, number of delineated points and corrections, zoom levels, level and window (L/W) settings, CT slice changes, use of side windows (coronal and sagittal) and software button use. Results: The mean delineation time per GTV was 16 min (SD 10 min). The mean delineation time for lymph node positive patients was on average 3 min larger (P=0.02) than for lymph node negative patients. Many corrections (55%) were due to L/W change (e.g. delineating in mediastinum L/W and then correcting in lung L/W). For the lymph node region, a relatively large number of corrections was found (3.7 corr/cm 2 ), indicating that it was difficult to delineate lymph nodes. For the tumor-atelectasis region, a relative small number of corrections was found (1.0 corr/cm 2 ), indicating that including or excluding atelectasis into the GTV was a clinical decision. Inappropriate use of L/W settings was frequently found (e.g. 46% of all delineated points in the tumor-lung region were delineated in mediastinum L/W settings). Despite a large observer variation in cranial and caudal direction of 0.72 cm (1 SD), the coronal and sagittal side windows were not used in 45 and 60% of the cases, respectively. For the more difficult cases, observer variation was smaller when the coronal and sagittal side windows were used. Conclusions: With the 'Big Brother' tool a method was developed to trace the delineation process. The differences between

  8. Congenital Hypogonadotropic Hypogonadism Due to GNRH Receptor Mutations in Three Brothers Reveal Sites Affecting Conformation and Coupling

    Science.gov (United States)

    Tello, Javier A.; Newton, Claire L.; Bouligand, Jerome; Guiochon-Mantel, Anne

    2012-01-01

    Congenital hypogonadotropic hypogonadism (CHH) is characterized by low gonadotropins and failure to progress normally through puberty. Mutations in the gene encoding the GnRH receptor (GNRHR1) result in CHH when present as compound heterozygous or homozygous inactivating mutations. This study identifies and characterizes the properties of two novel GNRHR1 mutations in a family in which three brothers display normosmic CHH while their sister was unaffected. Molecular analysis in the proband and the affected brothers revealed two novel non-synonymous missense GNRHR1 mutations, present in a compound heterozygous state, whereas their unaffected parents possessed only one inactivating mutation, demonstrating the autosomal recessive transmission in this kindred and excluding X-linked inheritance equivocally suggested by the initial pedigree analysis. The first mutation at c.845 C>G introduces an Arg substitution for the conserved Pro 282 in transmembrane domain (TMD) 6. The Pro282Arg mutant is unable to bind radiolabeled GnRH analogue. As this conserved residue is important in receptor conformation, it is likely that the mutation perturbs the binding pocket and affects trafficking to the cell surface. The second mutation at c.968 A>G introduces a Cys substitution for Tyr 323 in the functionally crucial N/DPxxY motif in TMD 7. The Tyr323Cys mutant has an increased GnRH binding affinity but reduced receptor expression at the plasma membrane and impaired G protein-coupling. Inositol phosphate accumulation assays demonstrated absent and impaired Gαq/11 signal transduction by Pro282Arg and Tyr323Cys mutants, respectively. Pretreatment with the membrane permeant GnRHR antagonist NBI-42902, which rescues cell surface expression of many GNRHR1 mutants, significantly increased the levels of radioligand binding and intracellular signaling of the Tyr323Cys mutant but not Pro282Arg. Immunocytochemistry confirmed that both mutants are present on the cell membrane albeit at low

  9. Non-marfan idiopathic medionecrosis (cystic medial necrosis) presenting with multiple visceral artery aneurysms and diffuse connective tissue fragility: Two brothers

    International Nuclear Information System (INIS)

    Kubota, Jun; Tsunemura, Mami; Amano, Shigeko; Tokizawa, Shigemi; Oowada, Susumu; Shinkai, Hiroko; Maehara, Yasunobu; Endo, Keigo

    1997-01-01

    Two brothers with multiple visceral artery aneurysms or dilatations and diffuse connective tissue fragility who did not have clinical features of Marfan syndrome are reported. One presented with retroperitoneal hemorrhage during angiography, and idiopathic medionecrosis was proved by resection of the aneurysms. These cases belong to the heterogeneous group of Marfan syndrome. The angiographical features (multiple dilation of visceral arteries) suggests fragility of connective tissue and is predictive of hazards during and after a catheterization and operation

  10. THE EVANGELICAL AS THE NATIVE IN THE “BROTHERS KARAMAZOV” AND IN “A WRITER’S DIARY” (1876–1877) BY FYODOR DOSTOEVSKY

    OpenAIRE

    Elena A. Fedorova

    2015-01-01

    The article identifi es the reasons for Fyodor Dostoevsky’s appeal to the traditions of Old Russian literature in “A Writer’s Diary” during the Russian-Turkish war. One of the main reasons is seeking for national foundations of Russian spirituality. The writer learned the world of medieval literacy getting acquainted with hagiography, walking, spiritual eloquence. Later Dostoevsky reverted to the Old Russian monuments in the course of his work on the novel “The Brothers Kara...

  11. [Sense of coherence and ways of coping in the relationship with brother or sister in healthy siblings of mentally ill persons].

    Science.gov (United States)

    Osuchowska-Kościjańska, Anna; Charzyńska, Katarzyna; Chadzyńska, Małgorzata; Drozdzyńska, Anna; Kasperek-Zimowska, Beata; Bednarek, Agata; Sawicka, Maryla

    2014-01-01

    The aim of the present study was to investigate sense of coherence in healthy siblings of persons suffering from schizophrenia as well as their ways of coping in the relationship with ill brother or sister. 40 healthy brothers and sisters of persons with ICD- 10 diagnosis of F20 to F29 participated in the present study. Orientation to Life Scale (SOC- 29) was used to assess sense of coherence and Ways of Coping with Stress questionnaire (SRSS) was used to examine stress coping strategies. Mean global score of siblings of persons with schizophrenia was 111 points. Subjects used coping strategies focused on problem significantly more often than those focused on emotions. Therapeutic work with healthy siblings should focus on strengthening sense of personal competence, development of personal resources and different ways of coping with stress, investigation of emotions that healthy siblings experience in the relationship with ill brother or sister as well as supporting the process of accepting changes in the relationship with the ill sibling.

  12. Three years follow-up of pamidronate therapy in two brothers with osteoporosis-pseudoglioma syndrome (OPPG) carrying an LRP5 mutation.

    Science.gov (United States)

    Barros, Elizabete Ribeiro; Dias da Silva, Magnus R; Kunii, Ilda S; Lazaretti-Castro, Marise

    2008-08-01

    Osteoporosis-pseudoglioma (OPPG) is a rare syndrome characterized by severe osteoporosis and ocular defects caused by homozygotic inactivation mutations in the LRP5 gene. Bisphosphonate has been demonstrated to improve bone mineral density (BMD) in children with OPPG. We present here a 3 years follow-up of two brothers with OPPG carrying a novel mutation in the LRP5 gene, who were treated with intravenous pamidronate. We looked for a mutation in the LRP5 gene in two brothers (12 and 4 years old) with clinical features of OPPG (blindness, low BMD and fragility fractures) and in their consanguineous parents to confirm the diagnosis of OPPG. The patients were treated with bisphosphonate for 3 years. They received 1 mg/kg/day of pamidronate for 2 consecutive days, every 3 months during the first year, and every 4 months in subsequent years. Calcium, phosphorus, total alkaline phosphatase, parathyroid hormone, hepatic transaminases, creatinine and hemogram tests were performed before each infusion. Bone densitometry was performed at baseline and at the end of the follow-up. The affected brothers carry a missense mutation in the third codon of exon 8 (AAT-->ATT) that led to the exchange of an asparagine for an isoleucine (N531I). Both parents were found to be heterozygous for this mutation. The intravenous pamidronate therapy was safe for up to 3 years of use. Moreover, increased BMD and decreased fracture rate were observed in our patients with OPPG.

  13. A novel homozygous AP4B1 mutation in two brothers with AP-4 deficiency syndrome and ocular anomalies.

    Science.gov (United States)

    Accogli, Andrea; Hamdan, Fadi F; Poulin, Chantal; Nassif, Christina; Rouleau, Guy A; Michaud, Jacques L; Srour, Myriam

    2018-04-01

    Adaptor protein complex-4 (AP-4) is a heterotetrameric protein complex which plays a key role in vesicle trafficking in neurons. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been recently associated with an autosomal recessive phenotype, consisting of spastic tetraplegia, and intellectual disability (ID). The overlapping clinical picture among individuals carrying mutations in any of these genes has prompted the terms "AP-4 deficiency syndrome" for this clinically recognizable phenotype. Using whole-exome sequencing, we identified a novel homozygous mutation (c.991C>T, p.Q331*, NM_006594.4) in AP4B1 in two siblings from a consanguineous Pakistani couple, who presented with severe ID, progressive spastic tetraplegia, epilepsy, and microcephaly. Sanger sequencing confirmed the mutation was homozygous in the siblings and heterozygous in the parents. Similar to previously reported individuals with AP4B1 mutations, brain MRI revealed ventriculomegaly and white matter loss. Interestingly, in addition to the typical facial gestalt reported in other AP-4 deficiency cases, the older brother presented with congenital left Horner syndrome, bilateral optic nerve atrophy and cataract, which have not been previously reported in this condition. In summary, we report a novel AP4B1 homozygous mutation in two siblings and review the phenotype of AP-4 deficiency, speculating on a possible role of AP-4 complex in eye development. © 2018 Wiley Periodicals, Inc.

  14. A dictionary without definitions: romanticist science in the production and presentation of the Grimm brothers' German dictionary, 1838-1863.

    Science.gov (United States)

    Kistner, Kelly

    2014-12-01

    Between 1838 and 1863 the Grimm brothers led a collaborative research project to create a new kind of dictionary documenting the history of the German language. They imagined the work would present a scientific account of linguistic cohesiveness and strengthen German unity. However, their dictionary volumes (most of which were arranged and written by Jacob Grimm) would be variously criticized for their idiosyncratic character and ultimately seen as a poor, and even prejudicial, piece of scholarship. This paper argues that such criticisms may reflect a misunderstanding of the dictionary. I claim it can be best understood as an artifact of romanticist science and its epistemological privileging of subjective perception coupled with a deeply-held faith in inter-subjective congruence. Thus situated, it is a rare and detailed case of Romantic ideas and ideals applied to the scientific study of social artifacts. Moreover, the dictionary's organization, reception, and legacy provide insights into the changing landscape of scientific practice in Germany, showcasing the difficulties of implementing a romanticist vision of science amidst widening gaps between the public and professionals, generalists and specialists.

  15. Columbia River wildlife mitigation habitat evaluation procedures report: Scotch Creek Wildlife Area, Berg Brothers, and Douglas County pygmy rabbit projects

    International Nuclear Information System (INIS)

    Ashley, P.R.; Ratassepp, J.; Berger, M.; Judd, S.L.

    1997-01-01

    This Habitat Evaluation Procedure study was conducted to determine baseline habitat units (HUs) on the Scotch Creek, Mineral Hill, Pogue Mountain, Chesaw and Tunk Valley Habitat Areas (collectively known as the Scotch Creek Wildlife Area) in Okanogan County, Sagebrush Flat and the Dormaler property in Douglas County, and the Berg Brothers ranch located in Okanogan County within the Colville Reservation. A HEP team comprised of individuals from the Washington Department of Fish and Wildlife, the Confederated Tribes of the Colville Reservation, and the Natural Resources Conservation Service (Appendix A) conducted baseline habitat surveys using the following HEP evaluation species: mule deer (Odocoileus hemionus), sharp-tailed grouse (Tympanuchus phasianellus), pygmy rabbit (Brachylagus idahoensis), white-tailed deer (Odocoileus virginiana), mink (Mustela vison), Canada goose (Branta canadensis), downy woodpecker (Picoides pubescens), Lewis woodpecker (Melanerpes lewis), and Yellow warbler (Dendroica petechia). Results of the HEP analysis are listed below. General ratings (poor, marginal, fair, etc.,) are described in Appendix B. Mule deer habitat was marginal lacking diversity and quantify of suitable browse species. Sharp-tailed grouse habitat was marginal lacking residual nesting cover and suitable winter habitat Pygmy rabbit habitat was in fair condition except for the Dormaier property which was rated marginal due to excessive shrub canopy closure at some sites. This report is an analysis of baseline habitat conditions on mitigation project lands and provides estimated habitat units for mitigation crediting purposes. In addition, information from this document could be used by wildlife habitat managers to develop management strategies for specific project sites

  16. Columbia River Wildlife Mitigation Habitat Evaluation Procedures Report / Scotch Creek Wildlife Area, Berg Brothers, and Douglas County Pygmy Rabbit Projects.

    Energy Technology Data Exchange (ETDEWEB)

    Ashley, Paul R.

    1997-01-01

    This Habitat Evaluation Procedure study was conducted to determine baseline habitat units (HUs) on the Scotch Creek, Mineral Hill, Pogue Mountain, Chesaw and Tunk Valley Habitat Areas (collectively known as the Scotch Creek Wildlife Area) in Okanogan County, Sagebrush Flat and the Dormaler property in Douglas County, and the Berg Brothers ranch located in Okanogan County within the Colville Reservation. A HEP team comprised of individuals from the Washington Department of Fish and Wildlife, the Confederated Tribes of the Colville Reservation, and the Natural Resources Conservation Service (Appendix A) conducted baseline habitat surveys using the following HEP evaluation species: mule deer (Odocoileus hemionus), sharp-tailed grouse (Tympanuchus phasianellus), pygmy rabbit (Brachylagus idahoensis), white-tailed deer (Odocoileus virginiana), mink (Mustela vison), Canada goose (Branta canadensis), downy woodpecker (Picoides pubescens), Lewis woodpecker (Melanerpes lewis), and Yellow warbler (Dendroica petechia). Results of the HEP analysis are listed below. General ratings (poor, marginal, fair, etc.,) are described in Appendix B. Mule deer habitat was marginal lacking diversity and quantify of suitable browse species. Sharp-tailed grouse habitat was marginal lacking residual nesting cover and suitable winter habitat Pygmy rabbit habitat was in fair condition except for the Dormaier property which was rated marginal due to excessive shrub canopy closure at some sites. This report is an analysis of baseline habitat conditions on mitigation project lands and provides estimated habitat units for mitigation crediting purposes. In addition, information from this document could be used by wildlife habitat managers to develop management strategies for specific project sites.

  17. Terapia de linguagem de irmãos com transtornos invasivos do desenvolvimento: estudo longitudinal Language therapy of brothers with pervasive developmental disorders: longitudinal study

    Directory of Open Access Journals (Sweden)

    Andréa Regina Nunes Misquiatti

    2010-01-01

    Full Text Available O objetivo deste trabalho foi descrever o processo de intervenção fonoaudiológica de dois irmãos com transtornos invasivos do desenvolvimento, por meio de um estudo longitudinal de caso clínico. Participaram dois irmãos, um de nove e outro de 11 anos de idade, ambos do gênero masculino, com autismo (Caso 1 e transtorno invasivo do desenvolvimento sem outra especificação (Caso 2. Como procedimento de coleta e análise de dados foi realizado um estudo longitudinal, por meio de acompanhamento dos casos ao longo de quatro anos de intervenção fonoaudiológica. Foram realizadas filmagens durante as sessões de terapia, análise documental de informações dos prontuários referentes à anamnese, avaliação e relatórios terapêuticos fonoaudiológicos, exames e avaliações multidisciplinares. Em ambos os casos houve melhora no contato visual, na interação social, no vocabulário e na brincadeira simbólica. No Caso 1 ocorreu aumento de 2,0 para 6,2 atos comunicativos por minuto, no Caso 2 de 3,5 para 8,0 atos e ambos demonstraram predominância do meio verbal e maior variedade de funções comunicativas. Outros fatores influenciaram estes resultados, como a deficiência intelectual, a dinâmica familiar, os conflitos no relacionamento entre os irmãos e o ambiente escolar em que estavam inseridos. Confirmou-se a relevância do fonoaudiólogo em intervenções nos transtornos invasivos do desenvolvimento, junto a equipes multidisciplinares, para a discussão diagnóstica e de condutas mais adequadas. Estudos longitudinais podem contribuir para uma análise mais detalhada e fidedigna de intervenções terapêuticas nesses casos, para esclarecer lacunas existentes na literatura e subsidiar a atuação do fonoaudiólogo clínico.The aim of this research was to describe the language intervention process of two brothers with pervasive developmental disorders, through a longitudinal clinical case study. Two brothers - one nine and the other 11

  18. THE EVANGELICAL AS THE NATIVE IN THE “BROTHERS KARAMAZOV” AND IN “A WRITER’S DIARY” (1876–1877 BY FYODOR DOSTOEVSKY

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    Elena A. Fedorova

    2015-11-01

    Full Text Available The article identifi es the reasons for Fyodor Dostoevsky’s appeal to the traditions of Old Russian literature in “A Writer’s Diary” during the Russian-Turkish war. One of the main reasons is seeking for national foundations of Russian spirituality. The writer learned the world of medieval literacy getting acquainted with hagiography, walking, spiritual eloquence. Later Dostoevsky reverted to the Old Russian monuments in the course of his work on the novel “The Brothers Karamazov” (in particular on the chapter “Th e Russian Monk”. As follows from the comparison of the texts the dominant qualities of the ideal image of a Russian saint are repentance, humility and suff ering, desire for purifi cation, spiritual ability to resist the evil. The ideal form of existence of Russian people becomes conciliarism. The type of historicism is the movement to the Last Judgment. Gospel allusions and metaphors reinforce the author’s interpretation. Th us, Dostoevsky carries on the dialogue with the evangelical word at an ideological, imaginative, genre, motive and narrative level of the text. Th e hallmark of the works of Fyodor Dostoevsky who followed the evangelical tradition, becomes a dialogical word.

  19. A Significant Source for the Madeleine and Other Major Episodes in Combray: Proust's Intertextual Use of Pierre Loti's My Brother Yves

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    Richard M. Berrong

    2014-01-01

    Full Text Available The most famous passage in Marcel Proust’s In Search of Lost Time , and one of the most famous passages in Western literature, is the moment when the narrator sips tea while eating a shell-shaped pastry called a madeleine and suddenly recalls very vividly an apparently long-forgotten scene from his childhood. From this episode Proust developed his theories about involuntary memory and its important role in our emotional welfare. Proust was an avid reader of the French novelist Pierre Loti when he was young. Contemporary accounts show that he was able to recite whole passages from Loti’s work in public from memory. This article demonstrates the extent to which Proust made intertextual use of scenes from Loti’s novel My Brother Yves in constructing the madeleine and other famous passages in Combray , the first section of In Search of Lost Time. It does not attempt to question the originality of Proust’s work. Rather, building on previous studies of intertextuality in Proust, it seeks to show how the author went about creating his work and dialoguing with at least some of his potential contemporary readers.

  20. Big Brother Experiments with the Regional Climate Model COSMO-CLM in an Idealised Setup to Investigate Lateral Boundary Conditions

    Science.gov (United States)

    Leps, Nora; Brauch, Jennifer; Ahrens, Bodo

    2017-04-01

    Our work aims at improving the regional coupled atmosphere-ocean model system COSMO-CLM/NEMO for decadal prediction. We address the different restricting conditions of regional climate modelling: Lower boundary conditions of the atmospheric system in the form of the coupled ocean, initial conditions and lateral boundary conditions of the coupled ocean-atmosphere system. Lateral boundary conditions (LBCs) are known to be an issue in dynamical downscaling with limited area regional climate models, and many studies have investigated the LBCs with regard to, e.g., frequency or resolution of LBCs, position of the domain and spurious effects. By default, the formulation of the LBCs in CCLM is a Davies relaxation scheme, which introduces a sponge layer at the lateral boundaries of the domain to dampen reflection of waves produced in the limited area domain at the prescribed boundaries. With idealised studies, it is possible to investigate the performance of this LBC formulation in CCLM in detail. The used framework is that of "big brother experiments" (BBEs). In a BBE, a high resolution simulation is performed over a larger domain, then its output is filtered to represent coarse-grid input, which is used to drive a nested smaller domain on the same high resolution. The differences between the two simulations can directly be attributed to the LBCs. Such experiments were performed in an idealised setup of a zonal flow over flat terrain or idealised hills with varying domain positions. First experiments show that for these idealised flows the relaxation works well for lateral boundary data on a high spatial resolution for different temporal resolutions. Next we plan to perform simulations with filtered lateral boundary data that only contains large scale features of the flow as well as different settings of the relaxation procedure.

  1. A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections.

    Science.gov (United States)

    Xu, Xiu; Xu, Qiong; Zhang, Ying; Zhang, Xiaodi; Cheng, Tianlin; Wu, Bingbing; Ding, Yanhua; Lu, Ping; Zheng, Jingjing; Zhang, Min; Qiu, Zilong; Yu, Xiang

    2012-08-21

    Autistic spectrum disorders (ASDs) are a family of neurodevelopmental disorders with strong genetic components. Recent studies have shown that copy number variations in dosage sensitive genes can contribute significantly to these disorders. One such gene is the transcription factor MECP2, whose loss of function in females results in Rett syndrome, while its duplication in males results in developmental delay and autism. Here, we identified a Chinese family with two brothers both inheriting a 2.2 Mb MECP2-containing duplication (151,369,305 - 153,589,577) from their mother. In addition, both brothers also had a 213.7 kb duplication on Chromosome 2, inherited from their father. The older brother also carried a 48.4 kb duplication on Chromosome 2 inherited from the mother, and a 8.2 kb deletion at 11q13.5 inherited from the father. Based on the published literature, MECP2 is the most autism-associated gene among the identified CNVs. Consistently, the boys displayed clinical features in common with other patients carrying MECP2 duplications, including intellectual disability, autism, lack of speech, slight hypotonia and unsteadiness of movement. They also had slight dysmorphic features including a depressed nose bridge, large ears and midface hypoplasia. Interestingly, they did not exhibit other clinical features commonly observed in American-European patients with MECP2 duplication, including recurrent respiratory infections and epilepsy. To our knowledge, this is the first identification and characterization of Chinese Han patients with MECP2-containing duplications. Further cases are required to determine if the above described clinical differences are due to individual variations or related to the genetic background of the patients.

  2. An incest case with three biological brothers as alleged fathers: Even 22 autosomal STR loci analysis would not suffice without the mother.

    Science.gov (United States)

    Canturk, Kemal Murat; Emre, Ramazan; Gurkan, Cemal; Komur, Ilhami; Muslumanoglu, Omer; Dogan, Muhammed

    2016-07-01

    Here, we report an incest paternity case involving three biological brothers as alleged fathers (AFs), their biological sister and her child that was investigated using the Investigator ESSplex Plus, AmpFLSTR Identifiler Plus/Investigator IDplex Plus and PowerPlex 16 kits. Initial duo paternity investigations using 15-loci autosomal short tandem repeat (STR) analyses failed to exclude any of the AFs. Despite the fact that one of the brothers, AF1, had a mismatch with the child at a single locus (D2S1338), the possibility of a single-step mutation could not be ruled out. When the number of autosomal STR loci analysed was increased to 22 without the inclusion of the mother, AF2 and AF3 still could not be excluded, since both of them again had no mismatches with the child. A breakthrough was possible only upon inclusion of the mother so that trio paternity investigations were carried out. This time AF1 and AF2 could be excluded at two loci (D2S1338 and D1S1656) and six loci (vWa, D1S1656, D12S391, FGA, PENTA E and PENTA D), respectively, and AF3 was then the only brother who could not be excluded from paternity. Subsequent statistical analyses suggested that AF3 could be the biological father of the child with a combined paternity index >100 billion and a probability of paternity >99.99999999%. These findings consolidate the fact that complex paternity cases such as those involving incest could benefit more from the inclusion of the mother than simply increasing the number of STR loci analysed. © The Author(s) 2015.

  3. Comparison between high-resolution climate simulations using single- and double-nesting approaches within the Big-Brother experimental protocol

    Science.gov (United States)

    Matte, Dominic; Laprise, René; Thériault, Julie Mireille

    2016-12-01

    Regional climate models (RCM) are widely used to downscale global climate models' (GCMs) simulations. As the resolution of RCM increases faster than that of GCM used for climate-change projections till the end of this century, the resolution jump will become an issue. Cascade with multiple nesting offers an approach to reach high resolution while keeping reasonable computational cost. Few studies have addressed whether the best results are obtained with the single- or multiple-nesting approaches. In this study the results obtained with single and double nesting are compared within the idealised "perfect model" framework of the Big-Brother Experiment. This method consists in first realizing a simulation, nicknamed the Big-Brother (BB) simulation, on a relatively large domain at the desired resolution, to serve as reference dataset. The BB results are then processed by a low-pass filter to emulate a coarse-resolution dataset to be used as LBC to drive further simulations, nicknamed the Little-Brother (LB) simulations, using an identical model formulation and resolution as the BB simulation. For the single nesting, the LB simulations are directly simulated, while for the double nesting a surrogate intermediate-resolution simulation is used. The study of the time-mean (stationary) component shows that little difference is noted between the single- and double-nesting approaches. The time-deviation (transient-eddy) component, however, shows important differences. The double-nesting approach weakly degrades the large scales but allows a significant reduction of the required domain size to allow adequate spin-up of fine-scale features. This results in an important saving in the computational cost.

  4. Adult onset supranuclear ophthalmoplegia, cerebellar ataxia, and neurogenic proximal muscle weakness in a brother and sister: another hexosaminidase A deficiency syndrome.

    Science.gov (United States)

    Harding, A E; Young, E P; Schon, F

    1987-01-01

    An Ashkenazi Jewish brother and sister developed progressive ataxia and proximal neurogenic muscle weakness, associated with supranuclear ophthalmoplegia, in the fourth decade of life. Hexosaminidase A activity, assayed using both synthetic and natural substrates, was severely reduced in the patients' plasma, leukocytes, and skin fibroblasts. Enzyme activity in their parents was in a similar range to that seen in heterozygotes for Tay-Sachs disease. The increasing evidence for marked clinical and molecular heterogeneity in the GM2 gangliosidoses warrants their consideration in the diagnosis of multisystem degenerative neurological disorders, even if onset of symptoms is in adult life. Images PMID:2956362

  5. DOSTOEVSKY'S CONCEPT OF HOLY BODY IN THE STRUCTURE OF "THE BROTHERS KARAMAZOV" (RELIGIOUS AND AESTHETIC ASPECTS

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    Natalia Zhivolupova

    2012-12-01

    Full Text Available The problem of the aesthetic and philosophical significance of the body in Dostoevsky’s creative writing is intimately connected with the structure of his formally intricate novels. The inner structure of Dostoevsky's novels illuminates the representation of the body in his opus as an innate part of Dostoevsky's poetics. The concept of the body includes an aesthetic as well as philosophical spectrum of problems, to which the interest in the topic from both literary critics and philosophers attests.

  6. Two Silent Brothers. Althusser and Foucault at the Crossroads of Ideology

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    Diego Melegari

    2014-07-01

    Full Text Available The article aims to reinterpret the relationship between Louis Althusser and Michel Foucault on the specific ground of the notion of "Ideology." If Foucault's critique addresses initially the alleged opposition between ideological discourse and scientific discourse, this does not seem to fade in the seventies, despite the convergence of Foucault's "microphysics of power"with Althusser's insistence on the "material" character of ideology. To explain the persistence of this comparison and of this tension the author shows how with it are involved highly problematic knots for the whole Foucault's thought: the status of representation and truth, the inner existence and temporality of capitalism and, in particular, the relationship between criticism and politics.

  7. The tale of the three brothers - Shh, Wnt and Fgf during development of the thalamus

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    Anja IH Hagemann

    2012-05-01

    Full Text Available The thalamic complex is an essential part of the brain that requires a combination of specialized activities to attain its final complexity. In the following review we will describe the induction process of the mid-diencephalic organizer (MDO where three different signaling pathways merge: Wnt, Shh and Fgf. Here, we dissect the function of each signaling pathway in the thalamus in chronological order of their appearance. First we describe the Wnt mediated induction of the MDO and compartition of the caudal forebrain, then the Shh mediated determination of proneural gene expression before discussing recent progress in characterizing Fgf function during thalamus development. Then, we focus on transcription factors, which are regulated by these pathways and which play a pivotal role in neurogenesis in the thalamus. The three signaling pathways act together in a strictly regulated chronology to orchestrate the development of the entire thalamus.

  8. O PROCESSO CRIATIVO EM THE BROTHER, DE ROBERT COOVER: UMA RELEITURA DO SAGRADO NA CONTEMPORANEIDADE

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    Fernanda Aquino Sylvestre

    2014-05-01

    Full Text Available Robert Coover é um importante escritor norte-americano preocupado com as perspectivas sociais, psicológicas, econômicas e políticas contemporâneas e com o modo como elas se configuram na formação da sociedade do seu país. Essa preocupação se reflete tanto nas técnicas de construção de suas histórias, quanto nas críticas apresentadas em suas narrativas. O trabalho em questão discute a reescrita que Coover faz de mitos bíblicos dentro do contexto pós-moderno, globalizado, compondo novos textos que subvertem os elementos tradicionais da narrativa. Mais especificamente, este artigo analisa a reescrita que o autor norte-americano empreende acerca da passagem bíblica da Arca de Noé no conto “The Brother”.

  9. Driver’s Big Brother: How Smartphones Can Increase Driver’s Awareness

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    Ashraf Khalil

    2012-10-01

    Full Text Available Using mobile devices while driving has been widely shown to pose serious safety risk. Various approaches aim at mitigating the risk of mobile devices while driving. Some initiatives have focused on increasing drivers’ awareness of such potential risk. Along the same vein, we present a model, and its implementation, for assessing the degree of distraction that drivers experience while using phones during driving. Based on data collected during each driving session, the application gives statistics, such as keypad interaction, number and length of phone calls and the driving speed, to the driver. This should increase the awareness of drivers by helping them understand how much distraction they got involved with during driving and how much hazardous they can be to themselves and to others. Our experiments with drivers demonstrated the potential of the application at highlighting risky behavior, promoting awareness and motivating better driving.

  10. Big Brothers: hegemonía mediática en el proceso electoral de 2006

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    Jorge Balderas Domínguez

    2007-01-01

    Full Text Available El presente artículo analiza la manera en que la televisión mexicana cubrió el proceso electoral de 2006. Aborda también los vínculos de las dos principales empresas con las élites hegemónicas del país, ya sean éstas económicas o políticas, dependiendo la coyuntura histórica. A su vez, intenta desarrollar un análisis crítico basado en estudios teóricos sobre la función social de los medios, particularmente, de la omnipresencia de la televisión que pareciera erigirse en el Gran Hermano (que te vigila, en una nueva especie de mundo orwelliano.

  11. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Harrington, Deirdre M.

    2011-10-28

    Abstract Background Adolescent females have been highlighted as a particularly sedentary population and the possible negative effects of a sedentary lifestyle are being uncovered. However, much of the past sedentary research is based on self-report or uses indirect methods to quantity sedentary time. Total time spent sedentary and the possible intricate sedentary patterns of adolescent females have not been described using objective and direct measure of body inclination. The objectives of this article are to examine the sedentary levels and patterns of a group of adolescent females using the ActivPAL™ and to highlight possible differences in sedentary levels and patterns across the week and within the school day. A full methodological description of how the data was analyzed is also presented. Methods One hundred and eleven adolescent females, age 15-18 yrs, were recruited from urban and rural areas in the Republic of Ireland. Participants wore an ActivPAL physical activity monitor for a 7.5 day period. The ActivPAL directly reports total time spent sitting\\/lying every 15 seconds and accumulation (frequency and duration) of sedentary activity was examined using a customized MATLAB ® computer software programme. Results While no significant difference was found in the total time spent sitting\\/lying over the full 24 hour day between weekday and weekend day (18.8 vs. 18.9 hours; p = .911), significantly more sedentary bouts of 1 to 5 minutes and 21 to 40 minutes in duration were accumulated on weekdays compared to weekend days (p < .001). The mean length of each sedentary bout was also longer (9.8 vs. 8.8 minutes; p < .001). When school hours (9 am-3 pm) and after school hours (4 pm-10 pm) were compared, there was no difference in total time spent sedentary (3.9 hours; p = .796) but the pattern of accumulation of the sedentary time differed. There were a greater number of bouts of > 20 minutes duration during school hours than after school hours (4.7 vs. 3

  12. From Dominators to be Brothers: a dialogue of ecotheologie with J. Riechmann about the Animal Liberation

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    Afonso Tadeu Murad

    2016-12-01

    Full Text Available Jorge Riechmann is the author of extensive work devoted to philosophical reflection on ecology and sustainability. Among his significant works, we choose "Todos los animales somos hermanos" (2005. We will present an overview of the author's thinking about the relationship of humans with other animals, especially mammals. Riechmann addresses hot topics such as physio-biological-social continuous process of evolution and uniqueness of the human; the reasons to include the higher animals in the human moral community, and ethical and legal reasons of animal rights. It must be overcome speciesism, which considers only the animals as mere instruments. Although animals are not people, not moral agents, have intrinsic value. Because they feel pain and pleasure, and have a purpose for living, they deserve moral respect. They are "almost people" and have rights granted and recognized by humans. Next, we will do an exercise of ecotheology interlocution with Jorge Riechmann. We will take as reference the Encyclical Laudato Si and the work of Susin and Zampieri, Ethics and Theology of Animal Liberation.

  13. 'How we learned to kill our brother'?: memory, morality and reconciliation in Peru

    Directory of Open Access Journals (Sweden)

    2000-01-01

    Full Text Available “COMMENT AVONS-NOUS APPRIS A TUER NOS FRERES ?” : MEMOIRE, MORALE ET RECONCILIATION AU PEROU. Dans cet article nous nous demandons comment certains paysans d’Ayacucho (Pérou analysent à la fois la violence politique qui a façonné leur vie quotidienne depuis 1980 et l’ordre de tuer qui a pris forme dans le contexte du conflit armé entre Sentier Lumineux, les Forces Armées Péruviennes et les rondes paysannes. Depuis 1995, nous conduisons à cet effet une recherche anthropologique dans diverses communautés du département d’Ayacucho. Nous cherchons ici à voir comment le contexte de guerre structure la vie morale en défiant les règles élémentaires du comportement humain et le sens même de la vie en communauté. Nous avons recours à une approche généalogique pour analyser les origines des interprétations morales qui surgissent dans des contextes locaux spécifiques. Aussi bien dans le processus de militarisation et de démilitarisation de la vie quotidienne, les cadres moraux qui transparaissent à travers les récits des paysans s’avèrent être un mélange synchrétique de christianisme militant, de thèmes psycho-culturels et de l’appropriation de discours extra-locaux. “¿CÓMO APRENDIMOS A MATAR A NUESTROS HERMANOS?”: MEMORIA, MORALIDAD Y RECONCILIACIÓN EN EL PERÚ. En este artículo, exploramos cómo los campesinos en Ayacucho (Perú entienden tanto la violencia política que ha moldeado la vida cotidiana desde 1980, como el mandato de matar que surgió dentro del contexto del conflicto armado entre Sendero Luminoso, las Fuerzas Armadas Peruanas, y las rondas campesinas. Hemos estado llevando a cabo una investigación antropológica desde 1995 en varias comunidades en el departamento de Ayacucho. Pretendemos explorar cómo el contexto de guerra moldea la vida moral, desafiando concepciones de la conducta humana aceptable y el sentido mismo de vivir en una comunidad humana. Utilizamos un acercamiento genealógico para

  14. 'Brothers in arms'

    DEFF Research Database (Denmark)

    Adamsen, L; Rasmussen, J M; Pedersen, L S

    2001-01-01

    The study investigated how a group intervention programme (13 sessions over 16 weeks), designed for men with cancer (n = 17), affected their sense of well-being and had a positive impact on their ability to cope with the physical, psychological and social consequences of living with cancer. The c...

  15. Big Brother Not Needed.

    Science.gov (United States)

    Heinen, Edward

    1983-01-01

    Cites the recent United States State Department's labeling of recent Canadian films--one on nuclear war and two on acid rain--as political propaganda as a sign of the need to review the nature of propaganda. Suggests that teaching students to intelligently evaluate propaganda is preferable to submitting to government dictum. (MM)

  16. Band of Brothers

    DEFF Research Database (Denmark)

    Pærregaard, Karsten

    2011-01-01

    Kapitlet diskuterer den rolle, som katolske broderskaber spiller i peruanske migranters religiøse praksis i USA, Spanien og andre lande. Den introducerer kort de katolske broderskabers historie i Spanien og det kolonial Latin Amerika og undersøger derpå det spirituelle slægtskab, som forbinder pe...

  17. Mercury is Moon's brother

    International Nuclear Information System (INIS)

    Ksanfomalifi, L.V.

    1976-01-01

    The latest information on Mercury planet is presented obtained by studying the planet with the aid of radar and space vehicles. Rotation of Mercury about its axis has been discovered; within 2/3 of its year it executes a complete revolution about its axis. In images obtained by the ''Mariner-10'' Mercurys surface differs little from that of the Moon. The ''Mariner-10'' has also discovered the Mercurys atmosphere, which consists of extremely rarefied helium. The helium is continuously supplied to the planet by the solar wind. The Mercury's magnetic field has been discovered, whose strength is 35 x 10 -4 at the Equator and 70 x 10 -4 E at the poles. The inclination of the dipole axis to the Mercury's rotation axis is 7 deg

  18. Brother of the regulator of the imprinted site (BORIS variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy.

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    Ryota Horibe

    Full Text Available Lung cancer is one of the most common malignancies with a high rate of mortality. Lung cancer stem-like cells (CSCs/ cancer-initiating cells (CICs play major role in resistance to treatments, recurrence and distant metastasis and eradication of CSCs/CICs is crucial to improve recent therapy. Cytotoxic T lymphocytes (CTLs are major effectors of cancer immunotherapy, and CTLs recognize antigenic peptides derived from antigens that are presented by major histocompatibility complex (MHC class I molecules. In this study, we analyzed the potency of a cancer-testis (CT antigen, brother of the regulator of the imprinted site variant subfamily 6 (BORIS sf6, in lung CSC/CIC immunotherapy. BORIS sf6 mRNA was expressed in lung carcinoma cells (9/19, especially in sphere-cultured lung cancer stem-like cells, and in primary lung carcinoma tissues (4/9 by RT-PCR. Immunohistochemical staining using BORIS sf6-specific antibody revealed that high expression of BORIS sf6 is related to poorer prognosis. CTLs could be induced by using a human leukocyte antigen, (HLA-A2 restricted antigenic peptide (BORIS C34_24(9, from all of 3 HLA-A2-positive individuals, and CTL clone cells specific for BORIS C34_24(9 peptide could recognize BORIS sf6-positive, HLA-A2-positive lung carcinoma cells. These results indicate that BORIS sf6 is a novel target of lung cancer immunotherapy that might be useful for targeting treatment-resistant lung cancer stem-like cells.

  19. Síndrome de Waardenburg: achados audiológicos em 2 irmãos Waardenburg's syndrome: audiological findings in 2 brothers

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    Carlos Henrique F. Martins

    2003-01-01

    Full Text Available A síndrome de Waardenburg foi inicialmente descrita em 1951 por P.J. Waardenburg, como uma condição autossômica dominante que apresenta penetrância e expressividade variáveis de seus caracteres. Os sinais clínicos mais frequentes são: deslocamento lateral dos cantos internos dos olhos (telecanto, hiperplasia da porção medial dos supercílios (sinofris, base nasal proeminente e alargada, alterações na pigmentação da íris e da pele, surdez congênita, mecha branca frontal ou encanecimento precoce. Este estudo foi realizado em dois irmãos de uma família, que apresentavam características clínicas da síndrome de Waardenburg, entre elas a deficiência auditiva. Os pacientes foram submetidos à uma avaliação otorrinolaringológica, audiológica e genética.Waardenburg's Syndrome, first described in 1951 by P.J. Waardenburg, is an autossomal dominant condition with variable penetrance and expressivity of its features. The clinical signs are lateral displacement of the inner canthi of the eyes, confluent eyebrows, broad and prominent nasal root, pigmentation changes of the irises and skin, sensorineural deafness, white forelock or early graying of the hair. This study was based on two brothers who presented a typical clinical picture of Waardenburg's Syndrome, including hearing loss. Otolaryngological, audiological and genetical evaluations were conducted.

  20. Gregorio y Francisco Esparza: hermanos enfrentados ante la independencia de Texas, 1835-1836 Gregorio and Francisco Esparza: Brothers Who Fought Each Other During the Independence of Texas, 1835-1836

    Directory of Open Access Journals (Sweden)

    Gustavo Ernesto Emmerich

    2012-08-01

    Full Text Available En 1836 el ejército mexicano tomó el fuerte de El Álamo, en las afueras de San Antonio. Todos sus defensores, que combatían por la independencia de Texas, murieron en la acción, entre ellos Gregorio Esparza, un nativo de esa ciudad. Tras la batalla, su hermano Francisco, enrolado en el bando mexicano, le dio cristiana sepultura. Este artículo examina la saga de ambos hermanos virtualmente desconocida en México. La primera sección de este artículo contextualiza la independencia de Texas, la segunda contiene resultados de investigación documental realizada por el autor sobre Gregorio y Francisco Esparza. La tercera comenta una entrevista realizada a un hijo de Gregorio sobre los papeles de su padre y su tío en El Álamo. La cuarta evalúa críticamente las evidencias. La quinta ofrece una reflexión sobre los motivos que habrían llevado a los hermanos Esparza -y en general a la comunidad texana de origen mexicano- a enfrentarse respecto a la independencia de Texas y, finalmente, en los anexos se transcriben los registros parroquiales y censales de la época y se extractan y comentan diversos relatos del hijo de Gregorio y de otros descendientes.In 1836, the Mexican army captured Fort Alamo outside San Antonio. All its defenders, who were fighting for the independence of Texas, died in action. Among these was Gregorio Esparza, a native of that city. After this battle, his brother Francisco, enlisted in the Mexican army, gave him a Christian burial. This article examines the saga of the two brothers, virtually unknown in Mexico. The first section contextualizes the independence of Texas. The second contains the results of the author's documentary research on Gregorio and Francisco Esparza. The third comments on an interview with one of Gregorio's sons on the roles played by his father and uncle at The Alamo. The fourth critically evaluates the evidence. The fifth provides a reflection on the reasons that led the Esparza brothers -and the

  1. Surgical Treatment for Epstein-Barr Virus Otomastoiditis Complicated by Facial Nerve Paralysis: A Case Report of Two Young Brothers and Review of Literature.

    Science.gov (United States)

    Eeten, Evelien van; Faber, Hubert; Kunst, Dirk

    2017-04-01

    We report the case of two young brothers with Epstein-Barr virus (EBV) otomastoiditis complicated by a facial nerve paralysis. The boys, aged 7 months (patient A) and 2 years and 8 months (patient B), were diagnosed with a facial nerve paralysis House-Brackmann (HB) grade IV (A) and V (B). After unsuccessful pharmacological treatment, patient A underwent mastoidectomy and atticoantrotomy and patient B underwent a transmastoidal surgical decompression of the facial nerve. They recovered to HB grades I and II facial nerve palsy (FNP), respectively. Although rare and relatively unknown, EBV should be considered in the differential diagnosis of children with FNP of unknown cause. Surgical intervention may be a viable therapy with good recovery.

  2. Characteristics of Cu isotopes from chalcopyrite-rich black smoker chimneys at Brothers volcano, Kermadec arc, and Niuatahi volcano, Lau basin

    Science.gov (United States)

    Berkenbosch, H. A.; de Ronde, C. E. J.; Paul, B. T.; Gemmell, J. B.

    2015-10-01

    We analysed primary chalcopyrite from modern seafloor `black smoker' chimneys to investigate high-temperature hydrothermal Cu isotope fractionation unaffected by metamorphism. Samples came from nine chimneys collected from Brothers volcano, Kermadec arc, and Niuatahi volcano, Lau backarc basin. This is the first known study of Cu isotopes from submarine intraoceanic arc/backarc volcanoes, with both volcanoes discharging significant amounts of magmatic volatiles. Our results ( n = 22) range from δ65Cu = -0.03 to 1.44 ± 0.18 ‰ (2 sd), with the majority of samples between ˜0.00 and 0.50 ‰. We interpret this cluster ( n = 17) of lower δ65Cu values as representing a mantle source for the chimney Cu, in agreement with δ65Cu values for mantle rocks. The few higher δ65Cu values (>0.90 ‰) occur (1) within the same chimneys as lower values, (2) randomly distributed within the chimneys (i.e. near the top and bottom, interior and exterior), and (3) within chalcopyrite of approximately the same age (responsible for the observed isotopic fractionation. When compared to global δ65Cu data for primary chalcopyrite, volcanic arc chimneys are most similar to porphyry copper deposits that also form from magmatic-hydrothermal processes in convergent tectonic settings.

  3. Duas variantes da representação do real na cultura midiática: o exorbitante Big Brother brasil e o circunspeto Edifício Master

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    Fernando Andacht

    2005-06-01

    Full Text Available The text aims at describing a remarkable phenomenon in our present day media culture: the representation of the real in television and cinema. Through the comparison between two audiovisual genres which deal with the real in the media, the Edificio Master documentary, directed by Eduardo Coutinho, and the Big Brother Brasil television program, the aim is to understand the cultural signification of two very different esthetic products that, nevertheless, share the dominant use of indexical signs, as their specific strategy. Without trying to minimize the obvious esthetic and ethic differences that exist between the reality show of the multinational company Endemol and the highly acclaimed Brazilian film, the article considers a fundamental tendency in present day media culture, namely, the techological and artistic production of an illusory intimacy at a distance, as a way of reflecting on identity. The functioning of the reality show aims at wrenching out of its orbit the normality of its participants, who must dwell in an abnormal place; the documentary, on the other hand, aims at offering a circumspect and moral vision of our everyday world, there where life takes place.

  4. ['Charitable brothers' in charge of hospitals in early modern times: The hospital in Linz/Austria and its patients up to c. 1780].

    Science.gov (United States)

    Watzka, Carlos

    2008-01-01

    The article deals with the history of the Hospital of the Brothers of St. John of God (in German: "Barmherzige Brüder"; official name "Ordo Hospitalarius Sancti Joannis a Deo") in the capital of Upper Austria, Linz, from its founding in 1757 to c. 1780. Primarily, the organisational development and the patients of the institute are discussed. The order's hospital already functioned as a medical hospital for the treatment of acute diseases: It was oriented towards the reestablishment of health of its inmates during short time and offered treatment by a staff of learned medical experts, among them academically trained physicians. The accommodation of the patients yet took place in a largely undifferentiated manner, as most of them were situated in a large common hall. This was obviously a consequence of the comparatively little capacity of the organisation, too, which sustained about 12 beds in the beginning, and about 20 around 1780. Nonetheless, the number of patients treated there summed up to nearly 1% of the entire male population of Upper Austria even during the first decade of its existence. In early modern time, only men were admitted to this hospital, the average age of them being only ca. 30 years. As far as social status is concerned, most of them (according to a representative sample out of the admissions of 1757-1767) were handicraftsmen (more than two thirds), labourers and servants. Thus, the organisation was obviously destined to broad social strata, but by no way displays itself as a poorhouse. Average annual mortality was 10 to 13%, which is comparable to that of other hospitals of the order in 18th century Austria. Most of the admitted persons suffered from "fever" or inner diseases and were dismissed as healed already after some weeks of stay.

  5. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

    Science.gov (United States)

    Kavran, Jennifer M; Ward, Matthew D; Oladosu, Oyindamola O; Mulepati, Sabin; Leahy, Daniel J

    2010-08-06

    Hedgehog (Hh) signaling proteins stimulate cell proliferation, differentiation, and tissue patterning at multiple points in animal development. A single Hh homolog is present in Drosophila, but three Hh homologs, Sonic Hh, Indian Hh, and Desert Hh, are present in mammals. Distribution, movement, and reception of Hh signals are tightly regulated, and abnormal Hh signaling is associated with developmental defects and cancer. In addition to the integral membrane proteins Patched and Smoothened, members of the Drosophila Ihog family of adhesion-like molecules have recently been shown to bind Hh proteins with micromolar affinity and positively regulate Hh signaling. Cell adhesion molecule-related, down-regulated by oncogenes (CDO) and Brother of CDO (BOC) are the closest mammalian relatives of Drosophila Ihog, and CDO binds Sonic Hh with micromolar affinity and positively regulates Hh signaling. Despite these similarities, structural and biochemical studies have shown that Ihog and CDO utilize nonorthologous domains and completely different binding modes to interact with cognate Hh proteins. We report here biochemical and x-ray structural studies of Sonic, Indian, and Desert Hh proteins both alone and complexed with active domains of CDO and BOC. These results show that all mammalian Hh proteins bind CDO and BOC in the same manner. We also show that interactions between Hh proteins and CDO are weakened at low pH. Formation of Hh-mediated Hh oligomers is thought to be an important feature of normal Hh signaling, but no conserved self-interaction between Hh proteins is apparent from inspection of 14 independent Hh-containing crystal lattices.

  6. Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)

    DEFF Research Database (Denmark)

    Vorwerk, P; Christoffersen, C T; Müller, J

    1999-01-01

    to be compound heterozygotes for mutations in the IR gene. The maternal allele was alternatively spliced in exon 17 due to a point mutation in the -1 donor splice site of the exon. The abnormal skipping of exon 17 shifts the amino acid reading frame and leads to a truncated IR, missing the entire tyrosine kinase......The insulin receptor (IR) in two brothers with a rare syndrome of congenital muscle fiber type disproportion myopathy (CFTDM) associated with diabetes and severe insulin resistance was studied. By direct sequencing of Epstein-Barr virus-transformed lymphocytes both patients were found...

  7. Insondável travessia (Rocco e seus irmãos Deep journey (Rocco and his brothers

    Directory of Open Access Journals (Sweden)

    Octavio Ianni

    1999-12-01

    Full Text Available Os temas da migração, da memória e do destino são evocados nesse ensaio inspirado no filme de Visconti.The themes of migration, of memory and of destiny are evoked in this essay inspired by Visconti's film.

  8. Big Brother, little brother en de discussie over privacy

    NARCIS (Netherlands)

    Dr. Martijn de Groot

    2014-01-01

    In 1949 publiceerde George Orwell zijn boek ‘1984’, waarin hij een beklemmende samenleving beschrijft: een wereld die totaal gecontroleerd wordt door de overheid, waarbij élke stap die je doet wordt geregistreerd en zelfs het denken aan banden is gelegd. Nu, 65 jaar later, lijkt het niet Big

  9. O brother, where art thou? Investment in siblings for inclusive fitness benefits, not father absence, predicts earlier age at menarche.

    Science.gov (United States)

    Smith, Daniel

    2017-10-01

    Numerous studies have indicated that father absence is associated with earlier age at menarche, with many evolutionary theories assuming that father absence is a causal factor that accelerates reproductive development. However, an alternative interpretation suggests that offspring may reproduce earlier in the presence of half- or step-siblings as the indirect fitness benefits to investing in them are lower, relative to delaying reproduction and investing in full siblings. From this perspective, father absence may perform no causal role in facilitating the onset of menarche. Using data from the Avon Longitudinal Study of Parents and Children, I find that individuals with only half- or step-siblings reach reproductive age earlier than those with only full siblings, with no independent effect of father absence. These results suggest that inclusive fitness benefits to investing in siblings, rather than father absence, may predict variation in age at menarche. These results provide a greater understanding of the adaptive mechanisms involved in reproductive decision-making, as well as potential implications for human life-history evolution and cooperative breeding more broadly. © 2017 The Authors.

  10. The Brothers Grimm in The Library of the National Museum of Slovenia: the Legacy of Anastazij Grün

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    Urška Pajk

    2013-11-01

    Full Text Available ABSTRACTThe article is focused on the “treasures” of the National Museum of Slovenia Library a part of them being the books of the count Anton Alexander Auersprg writing under the pseudonym of Anastazij Grün. In 1910 his legacy was included into the museum’s book collection. The poet Anastazij Zelenc was an interesting and unique historical personage and a passionate collector of books and other printed materials. He became especially enthusiastic about antique history and folk literature. Thus, it is not surprising to find the Grimm’s literary “production” in his collection. Anastazij Grün is not sufficiently known in Slovenia. Therefore it is convenient to underline his importance at the occasion of the 150th anniversary of the death of the great fairy tale writer, ethnologist and philologist Jacob Grimm (20th September 2013.

  11. Sibling Death after Being Thrown from Window by Brother with Autism: Defenestration, an Emerging High-Risk Behavior

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    Osman Sabuncuoglu

    2015-01-01

    Full Text Available Children diagnosed with autistic spectrum disorders (ASD may have serious behavioral problems such as aggression, self-injury, and violence. However, the literature on ASD either overrules any correlation between aggression and ASD or maintains the fact that the efforts to link them have so far been inconclusive. Although severe forms of violence are extremely rare in children with autism, there are a few cases reported in the literature with significant harm to siblings. We hereby report an 8-year-old boy with ASD who caused the death of his sibling by throwing her out of the window. Shared similarities of all defenestration cases indicate a pattern of high-risk behavior threatening the survival of minors. We recommend precautions against this high-risk behavior in children with ASD.

  12. Brothers in arms or peace? The media representation of Swedish and Norwegian defence- and military co-operation

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    Stig Arne Nohrstedt

    2010-10-01

    Full Text Available This article discusses the relevance of Johan Galtung's model for peace journalism and critical discourse analysis (CDA in light of the media coverage of Swedish and Norwegian defence cooperation. By analysing the proposal for closer military cooperation between the Nato-member Norway and the non-aligned Sweden the article emphasises the paradox that the fact that both Sweden and Norway have forces fighting in Afghanistan was not mentioned when the heads of the Norwegian and Swedish Defence in a joint article justified the need for a closer cooperation between the two countries. Thus this analysis illustrates some limitations of the peace journalism perspective and the necessity to take a contextual approach in which also the possibility of "peace talk" being part of a war discourse is considered.

  13. HYMNOGRAPHIC 'CANON' AS A “FORM OF THE PLAN” IN “THE BROTHERS KARAMAZOV” BY DOSTOEVSKY

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    Elena Anatolyevna Osokina

    2012-11-01

    Full Text Available The article draws a parallel between divine service and art, using Dostoevsky's last grand masterpiece as an example. We begin by defining the canon as a genre and as a liturgical order. The order of songs in the canon and the liturgical order resemble the sequence of Dostoevsky's novel and make it ordered and recognizable. The form chosen by the author was more organic for Russian consequence than the novel in its Western version and more expressive for a piece of art. By shaping his novel into a canon as a hymnographic piece, Dostoevsky created a special form which helped his novel attain perfection. The form of canon as a hymnographic text is found in the novel's structure (“a form of a plan” which is made clear by the positioning of the life of Zosima. The novel's hidden meaning was thus expressed in its form. The structure of a canon reproduced in a piece of fiction allowed Dostoevsky to link the contemporary and the all-embracing, bring up eternally important issues of losing faith in God and provide true answers in the discovery of new faith in Jesus.

  14. BIG BROTHER IS WATCHING YOU! TO BE OR NOT TO BE ONLINE... OR SCREEN AS OUR OWN TECHNOLOGICAL ADDRESS

    Directory of Open Access Journals (Sweden)

    Vanda Maria Sousa

    2014-12-01

    Full Text Available This article seeks to answer the question: how the screens are interposed between the subject and reality, in contexts of the New Technologies of Information and Communication, particularly in the case of television screens (in the reality show format and computer screens (by the profusion of social networks? Using the interpretative methodology, our goal is to take as a starting point the etymology of technic and technology to establish the technological nature of man’s relationship with reality. Once this premise is demonstrated, we will convene the Heideggerian concepts (dasein and ge-stell to interpret how the technology of the screen meets a social need for happiness that comes from the media in a world that re-discovers itself as iconic. Each of us is called upon, in our day-to-day life, to an important, special and urgent meeting with the representation of our own selves, against a screen, where will be its own place of happiness. We intend to assess whether ideologies are hiper-evaluated today, especially when translating reality into binary conceptions of the world, projecting dasein on the demand for unity (1, opposing it to failure (0, each time using the screen more like a mirror or a window, and forgetting its function as a ge-stell by making it a promotion, and not doing it as a way to discover dasein, but, instead, as the opening of the simulacra itself.

  15. Separating Sisters From Brothers: Ethnic Relations and Identity Politics in the Context of Indigenous Land Titling in Indonesia

    Directory of Open Access Journals (Sweden)

    Stefanie Steinebach

    2017-06-01

    Full Text Available Environmental and social transformations in Jambi province, Indonesia, are inextricably interlinked. Large-scale agro-industrial development and nature conservation policies equally alienate local communities from their agricultural lands and turn land into a scarce resource. Consequently, access to agricultural land becomes increasingly contested, not only between communities and state institutions or companies but also among communities themselves. To secure or restore local ‘indigenous’ land rights against land grabbing and green grabbing by states and companies, indigenous land titling has become a powerful tool all over the world. Ongoing activities of indigenous land titling in Indonesia have been largely perceived as an act of justice by indigenous and land rights activists and affected communities. Yet, a challenging step towards titling is the identification of who is and who is not ‘indigenous’. This highly political process creates ethnicity-based identities tied to rights and possibilities around land as a contested resource. Based on a case study of a national park in central Jambi, this paper shows that what is perceived as an act of justice against the state can also produce injustice among local communities by heavily impacting and transforming local social structures and relations.

  16. Who is my brother's keeper?

    Science.gov (United States)

    Kottow, M H

    2002-02-01

    Clinical and research practices designed by developed countries are often implemented in host nations of the Third World. In recent years, a number of papers have presented a diversity of arguments to justify these practices which include the defence of research with placebos even though best proven treatments exist; the distribution of drugs unapproved in their country of origin; withholding of existing therapy in order to observe the natural course of infection and disease; redefinition of equipoise to a more bland version, and denial of post-trial benefits to research subjects. These practices have all been prohibited in developed, sponsoring countries, even though they invariably have pockets of poverty where conditions comparable to the Third World prevail. Furthermore, the latest update of the Declaration of Helsinki clearly decries double ethical standards in research protocols. Under these circumstances, it does not seem appropriate that First World scholars should propose and defend research and clinical practices with less stringent ethical standards than those mandatory in their own countries. Recent years have witnessed frequent reports of less stringent ethical standards being applied to both clinical and research medical practices, for the most part in the field of drug trials and drug marketing, initiated by developed countries in poorer nations. Still more unsettling, a number of articles have endorsed the policy of employing ethical norms in these host countries, which would be unacceptable to both the legislations and the moral standards of the sponsor nations. Also, these reformulations often contravene the Declaration of Helsinki or one of its updates. This paper is not so much concerned with the actual practices, which have been subjected to frequent scrutiny and publicly decried when gross misconduct occurred. Rather, my concern relates to the approval and support such practices have found in the literature on bioethics from authors who might be expected to use their energy and scholarship to explore and endorse the universalisability of ethics rather than to develop ad hoc arguments that would allow exceptions and variations from accepted moral standards. To this purpose, issue will be taken with arguments in three fields: medical and pharmaceutical practices, research strategies, and local application of research results.

  17. Conservation and restoration of the panel "Saint Sebastian calling on the faith of the Christian captive brothers Marcus and Marcellianus" from the Museum of Angra do Heroísmo, Terceira Island, Azores

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    Raúl Gregório

    2010-01-01

    Full Text Available This paper describes the methodology followed in the conservation and restoration of the panel "Saint Sebastian calling on the faith of the Christian captive brothers Marcus and Marcellianus", datable to the late sixteenth century, belonging to the ancient altarpiece in the presbytery of the Church São Sebastião (Saint Sebastian, Terceira Island, Azores, and currently at the Museum of Angra do Heroísmo. It begins by presenting an historical overview and an iconographic and artistic study of the panel, which proved crucial to the understanding of the subject and its setting at the time, the church and the whole altarpiece. The double meaning as a testimony of faith and a symbol of national identity in times close to or already in the process of loss of independence from Portugal, is achieved through the hagiographic representation of the patron saint of the church on a base of cedar wood (Juniperus brevifolia, which enables to infer an author or local production. In the late nineties of the twentieth century, this support showed an intense deterioration resulting from colonization by fungi (brown rot and previous interventions. The work done back than was held by various thinning of the wood and partial filling that allowed the restoration of the physical balance of each one of five boards and the panel as a whole. After this phase, the intervention was stopped, coming to resume in 2007, with the further stabilization of wood, reassembly, repainting survey and treatment of pictorial layer. The methodology was adapted to the most current criteria, keeping only what had once been widely followed in the areas affected by fungal action, with a clear structural instability and inability to recover only by consolidating.

  18. Novel about Artist: Postmodern Variations (Instantiated by Novels “The Tin Drum” by Günter Grass, “Brother of Sleep” by Robert Schneider, “Perfume: The Story of a Murderer” by Patrick Süskind

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    Sofiya Varetska

    2013-12-01

    Full Text Available An attempt to show the modification of classic novel about an artist (Künstlerroman through a prism of postmodernism instantiated by German novels of the second half of the twentieth century “The Tin Drum”, “Brother of Sleep”, “Perfume: The Story of a Murderer” was accomplished. Crisis of artistic apperception in the twentieth century is demonstrated. Different conceptions of the creative process of main characters are compared. The main attention was focused on the clash between man and artist, life and art, daily routine and spirituality. In the postmodern age the cynical worldview model is predominating. At the same time tales, where magic and reality, sentimentality and brutality are combined, enjoy widespread popularity. An art of genius has positive connotations in general, but some of chosen novels are revealing the reverse side of the coin, when the art is capable to create an evil in its superior manifestations. For a wonder a presence of negative, monstrosity and disgust attract attention of the crowd rather than beauty. Therefore tin the article new idea that talent is on the verge of monstrosity is asserted. These two concepts exist together rely on each other. Every hero is like two-faced Janus to some extent. On the one hand, being endowed with Divine Grace he has a talent, but on the other hand, having something demoniacal is possessed by physical defect. On the one hand, they limelight and fire our imagination by their unusualness, on the other hand, they push away by their monstrosity and disgust. Main characters are always teetering on the edge. However the notion of edge is taking the wider meaning in the contemporary society. Consequently, having used all features of classic novel about an artist and portrayed them through a prism of modern perception of the world, writers created a new compilation – postmodern novel about an artist.

  19. Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)

    DEFF Research Database (Denmark)

    Vorwerk, P; Christoffersen, C T; Müller, J

    1999-01-01

    to be compound heterozygotes for mutations in the IR gene. The maternal allele was alternatively spliced in exon 17 due to a point mutation in the -1 donor splice site of the exon. The abnormal skipping of exon 17 shifts the amino acid reading frame and leads to a truncated IR, missing the entire tyrosine kinase......The insulin receptor (IR) in two brothers with a rare syndrome of congenital muscle fiber type disproportion myopathy (CFTDM) associated with diabetes and severe insulin resistance was studied. By direct sequencing of Epstein-Barr virus-transformed lymphocytes both patients were found...... domain. In the correct spliced variant, the point mutation is silent and results in a normally translated IR. The paternal allele carries a missense mutation in the tyrosine kinase domain. All three cDNA variants were present in the lymphocytes of the patients. Purified IR from 293 cells overexpressing...

  20. Killing Brothers Legislation And Their Impact On The System Of Governance AL- Othman (1520-1617 شريعة قتل الأخوان وأثرها في نظام الحكم آل عثمان (1520-1617

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    Dr. Bushraa Nasser Hashim Alsaaedy م. د. بشرى ناصر هاشم الساعدي

    2011-12-01

    Full Text Available Ottoman state Faced throughout her reign, which lasted six centuries (1299-1922, many problems, had a clear impact in the ruling system. It was is in its infancy consolidate its power, and install its influence, to face external dangers surrounding its fledgling state entity. However, she found herself in the midst of serious internal problems was with temptation, and the competition between the sons and brothers of the sultans in anticipation of the throne of the Sultanate, and that was a cause for times the sultans influence in the inside, keeping their distance from their supreme goal of expansion and annexation outside the boundaries of the Sultanate. Has been a lot of brothers and sons of the sultans to murder or exclusion in the palaces of slaves, so unique new sultan ruling. But that it increased risk, with increased rivalry and conflict around the throne of the Sultanate, which led some of them to enter into agreements with their enemies in the neighboring United Arab Emirates them, or with foreign nations surrounding them, in order to obtain support and assistance to overthrow each other. If this case the Sultanate at home, which will become a contender for the throne ... To what extent was a reflection of that conflict in the ruling system. This is what we will try to follow in the folds of our humble research.

  1. Neurological syndromes and mental disorders in the literary characters of the novel «Bratya Karamazovy» (The Brothers Karamazov by F.M. Dostoevsky

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    А.А. Mikhailenko

    2014-01-01

    Full Text Available The novel «Bratya Karamazovy» by F.M. Dostoevsky presents a whole series of literary characters whose neuropsychiatric health cannot be considered to be impeccable. Various clinical conditions, such as neurasthenia, mental retardation, epilepsy, obsessive-compulsive and conversion-and-dissociative syndromes, may be retrospectively recognized with varying degrees of credibility and validity in many characters of the novel. In terms of belletristic literature, the description of their behavior and external manifestations is notable for brilliance, richness of content, surprising clinical accuracy, and scrupulosity.

  2. “‘Need a Minister? How About Your Brother?’: The Universal Life Church between Religion and Non-Religion”

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    Dusty Hoesly

    2015-10-01

    Full Text Available National media outlets have observed that weddings in the United States, especially for young educated people, are increasingly performed by ministers who are friends or relatives of the couple and who become ordained online just for that purpose. The primary organization licensing these ministers, and thus authorizing these weddings as legally valid, is the Universal Life Church (ULC, which has ordained over 20 million people since 1962. To date, there has been no focused study of the ULC or lifecycle rituals conducted under its auspices. According to my original survey, interview, and participant observation data, both ULC ministers and the couples who engage them typically self-describe as non-religious, usually as spiritual, seekers, humanist, or generically “not religious.” Similarly, they describe their weddings in “non-religious” terms, emphasizing the personalization of the ceremony to match their particular beliefs and tastes as well as the conscious exclusion of most “religious” language. These “secular” or “spiritual” wedding ceremonies reveal non-religious couples’ desires for an alternative apart from bureaucratic civil ceremonies or traditional religious rites. This article explains why “secular” people select ULC ministers for their weddings, how ULC ministers see themselves as “non-religious” while being members of a legally-recognized religion, and how ULC ministers and couples married by them label and valuate their “non-religious,” personalized wedding ceremonies. My examination of ULC membership and weddings reveals not only the diversity of non-theistic self-identification and lifecycle ritualization, but also how constructs such as “religious” and “secular” can be co-constitutive rather than purely oppositional.

  3. Desempenho psicolinguístico e escolar de irmãos com mielomeningocele Psycholinguistic and school performance of brothers with myelomeningocele

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    Dionísia Aparecida Cusin Lamônica

    2012-08-01

    Full Text Available TEMA: mielomeningocele e consequências para o desenvolvimento de habilidades psicolinguísticas e escolares. PROCEDIMENTOS: o objetivo deste estudo foi descrever e refletir sobre o desempenho psicolinguístico e escolar de irmãos com mielomeningocele lombar baixa. Participaram do estudo um menino de 14 anos e 5 meses (P1 e sua irmã de 6 anos e 6 meses (P2. Os procedimentos constaram de entrevista com familiares, Observação do Comportamento Comunicativo (OCC, Teste de Vocabulário por Imagens Peabody - TVIP, Teste Illinóis de Habilidades Psicolinguísticas (ITPA, Perfil de Habilidades Fonológicas (PHF, Teste de Desempenho Escolar (TDE, e Reconhecimento de letras e números (RLN. A análise dos resultados foi descritiva respeitando os manuais dos instrumentos. RESULTADOS: a linguagem oral encontra-se sem alteração evidente. No ITPA e PHF, verificou-se que P1 e P2 apresentaram dificuldade nas habilidades de memória, closura auditiva, expressão verbal, combinação de sons e consciência fonológica. P1 ainda apresentou dificuldade na habilidade de recepção visual e P2 nas habilidades de associação auditiva e closura gramatical. Ambas as crianças apresentaram alteração nas atividades de aprendizagem. CONCLUSÃO: os participantes do estudo apresentaram comportamento comunicativo, habilidades de linguagem oral e vocabulário receptivo sem alterações evidentes. P1 e P2 apresentaram alterações nas habilidades psicolinguísticas bem como no desempenho de atividades envolvendo leitura, escrita e aritmética. As dificuldades apresentadas causam impacto importante nas atividades acadêmicas, demonstrando vulnerabilidade cerebral no sistema de suporte para atividade de aprendizagem.BACKGROUND: meningomyelocele and consequences on the development of psycholinguistic and school abilities. PROCEDURES: the purpose of this study was to describe and reflect on the psycholinguistic and school performance of siblings with low lumbar

  4. 77 FR 75503 - Wright Brothers Day, 2012

    Science.gov (United States)

    2012-12-20

    .... Similar stories of resilient, canny entrepreneurship have unfolded throughout our Nation's history--from the founding of our airlines and auto industry to the growth of our research institutions and small businesses. While each journey has been unique, all have advanced that same brand of rugged determination to...

  5. 76 FR 79019 - Wright Brothers Day, 2011

    Science.gov (United States)

    2011-12-20

    ... collective memory. During the 12 seconds their aircraft remained aloft in Kitty Hawk's gusty headwinds... they overcame were tremendous, and Orville and Wilbur Wright's pioneering vision stands as a testament...

  6. HALF-BROTHERS IN THE SCHULHOF FAMILY?

    International Nuclear Information System (INIS)

    Vokrouhlicky, David; Nesvorny, David

    2011-01-01

    Disruptive collisions in the asteroid belt produced groups of fragments known as the asteroid families. The studies of identified asteroid families help us to better understand issues related to impact physics, space weathering, asteroid interior, and collisional evolution of the main belt. Here, we analyze a family near the central main belt asteroid (2384) Schulhof. We show that the previously found group of objects around (81337) 2000 GP36 is actually a sub-cluster in the larger Schulhof family. Using backward integrations we demonstrate that the orbits of sub-cluster asteroids converge to that of (2384) Schulhof at 780 ± 100 kyr ago, suggesting that the breakup event happened very recently. Interestingly, a similar analysis of the two newly discovered members of the Schulhof family may indicate a second event ∼< 100 kyr ago (e.g., secondary collision, fission, satellite instability). If confirmed, the formation history of the Schulhof family would suggest that small asteroids may have very colorful lifetimes. Additional astrometric observations of the two new member asteroids will be needed to improve their present orbit and better constrain their past histories.

  7. Unequal brothers : are homeopathy and hormesis linked?

    Science.gov (United States)

    Oberbaum, Menachem; Frass, Michael; Gropp, Cornelius

    2015-04-01

    The debate between those who believe homeopathy and hormesis derive from the same root and those who believe the two are different phenomena is as old as hormesis. It is an emotionally loaded discussion, with both sides fielding arguments which are far from scientific. Careful analysis of the basic paradigms of the two systems questions the claim of the homeopaths, who find similarities between them. The authors discuss these paradigms, indicating the differences between the claims of homeopathy and hormesis. It is time for thorough and serious research to lay this question to rest. One possible approach is to compare the activity of a hormetic agent, prepared in the usual way, with that of the same agent in the same concentration prepared homeopathically by serial dilution and succussion. Copyright © 2015. Published by Elsevier Ltd.

  8. 75 FR 80669 - Wright Brothers Day, 2010

    Science.gov (United States)

    2010-12-22

    ..., 1903, after years of determination and creativity, Orville and Wilbur Wright's wooden aircraft sailed... leadership and innovation has been the product of learning and ingenuity. To maintain this tradition and... children to become the entrepreneurs whose tenacity and creativity will power the engine of our Nation's...

  9. Il Lago di Celluloide: immagini e pratiche di una meta turistica d'élite nelle rappresentazioni cinematografiche dai fratelli Lumière a Geogrge Clooney / The “Celluloid Lake”: images and practices of an elitist tourism destination in film productions from Lumière Brothers to George Clooney

    Directory of Open Access Journals (Sweden)

    Giuseppe Muti

    2016-05-01

    Full Text Available Il lago di Como è un caso di studio paradigmatico per l'unicità della dotazione ambientale e culturale, per la storia turistica lunga oltre duecento anni, per la forza dell'immagine che comprende alcune icone globali. Letterarie, poetiche, narrative, pittoriche, figurative, le immagini ricreative del lago di Como si modificano e si moltiplicano dall'età classica a quella romantica, presentandosi già definite e consolidate agli albori delle tecnologie fotografiche e cinematografiche. Il lago di celluloide nasce nel 1897 quando i fratelli Lumière riprendono una competizione fra imbarcazioni a Bellagio. Da allora il lago assume differenti connotazioni e ruoli come set di un gran numero di opere cinematografiche, la cui analisi diacronica permette interessanti riflessioni sulla natura delle relazioni fra turismo e audiovisivo, sulle diverse percezioni e rappresentazioni culturali di una medesimo territorio e sulle prerogative iconografiche specifiche di alcuni luoghi centrali della globalizzazione mediatica, cinematografica e turistica.   The Como Lake case study is paradigmatic for the unique environmental and cultural features, for the two-hundred-years-long touristic tradition and for the strength of its image, involving global icons. The recreational pictures of Como Lake are literary, poetic, narrative and pictorial. They have been constantly changing and multiplying beginning from the Classic to the Romantic Age, and became well-defined and strengthened before the dawn of photographic and cinematographic technologies. The "celluloid lake" debuts in 1897, when Lumière Brothers shoot a boat race in Bellagio. Since then, the lake took different connotations and roles as location for a large number of cinematographic productions, whose diachronic analysis leads to interesting thoughts on nature and the relationship between tourism and audiovisual footage, on different cultural perceptions and representations of the same territory and on the

  10. When “soul” is lost in translation: Metaphorical conceptions of “soul” in Dostoyevsky's original “Братья Карамазовы” (“The Brothers Karamazov” and its translations into Polish, Croatian and English

    Directory of Open Access Journals (Sweden)

    Julia Ostanina-Olszewska

    2017-12-01

    Full Text Available When soul is lost in translation: Metaphorical conceptions of soul in Dostoyevsky’s original Братья Карамазовы (The Brothers Karamazov and its translations into Polish, Croatian and English Given that our understanding of such an abstract concept as soul is almost purely metaphorical, this paper provides a comparative cross-linguistic analysis of the system of metaphorical conceptions of soul in Dostoyevsky’s original Братья Карамазовы (The Brothers Karamazov and its Polish, Croatian and English translations. Special attention is paid to those metaphors that are translated differently between the various translations, either in conceptual or linguistic terms. This paper adheres to the cognitive-linguistic approach to Mind (Reddy, 1979; Sweetser, 1990; G. Lakoff & Johnson, 1999. Consistent with conceptual metaphor theory in general (G. Lakoff & Johnson, 1980; G. Lakoff, 1987; Grady, 1997; Kövecses, 2000; G. Lakoff, 2009; etc., this paper’s theoretical and methodological approach is based on Sweetser’s (1990 analysis of the system of metaphors for knowledge, on G. Lakoff and Johnson’s (1999 systematic analysis of the metaphorical conceptions of Mind and Soul, and on Štrkalj Despot, Skrynnikova and Ostanina Olszewska’s (2014 comparative analysis of the metaphorical conceptions of ДУША/DUSZA/DUŠA (‘soul’ in Russian, Polish, and Croatian. The metaphors for soul were examined in a parallel corpus that consists of Dostoyevsky’s original Братья Карамазовы (The Brothers Karamazov and its Polish, Croatian and English translations. Linguistic metaphors were detected using the MIPVU procedure (Steen et al., 2010. The main questions that this paper ains to answer are: Which metaphors for conceptualizing soul are shared by all the languages in question? Which metaphors are translated differently and why? If metaphors are translated differently, is the difference conceptual, cultural or

  11. The 16th International Twin Congress: Highlights from Madrid/Twin Research: Twin Study of Partner Aggression; ABO Incompatibility in Dizygotic Twins; Growth Discordance in a Monoamniotic Twin Pair; Quick Note on Twin Implantation/In the Media: Long-Lost Twins Found; NASA Twin Experiment; Twin Brothers and the Las Vegas Attack; Retired Twin Airline Pilots; Twin Film Clips.

    Science.gov (United States)

    Segal, Nancy L

    2018-02-01

    Highlights from the 16th International Twin Congress, held in Madrid, Spain from November 16-18, 2017, are presented. The Twin Congress, formerly held every three years, now takes place biennially with a single-day meeting organized during the off years. This meeting is the largest gathering of scientific twin researchers, medical personnel, and representatives of multiple birth organizations in the world. This overview is followed by reviews of recent twin research and commentary concerning partner aggression, ABO incompatibility in dizygotic twins, growth discordance in a monoamniotic twin pair and twin implantation. The article closes with summaries of timely topics in the media, namely a father's finding of his long-lost twin children, early results from the NASA twin experiment, twin brothers at the center of the October 2017 Las Vegas attack, retired twin airline pilots, and clips from recent films with twin-based themes.

  12. O imigrante e seus irmãos: as pesquisas empíricas de Florestan Fernandes e Gino Germani The immigrant and his brothers: the empirical researches of Florestan Fernandes and Gino Germani

    Directory of Open Access Journals (Sweden)

    Antonio Brasil Jr.

    2010-01-01

    Full Text Available No trabalho, destaco, em perspectiva comparada, algumas formulações de Florestan Fernandes e de Gino Germani, protagonistas da renovação da sociologia nas universidades de São Paulo e de Buenos Aires, respectivamente. Através de pesquisas empíricas, os dois procuraram investigar em que sentido a modernização afetava diferencialmente os grupos sociais, repondo padrões seculares de desigualdade. Fernandes e Germani viram, ainda, no "imigrante de ultramar", o portador por excelência das mudanças em curso, porquanto teria logrado se inserir, tanto em São Paulo quanto em Buenos Aires, nas posições mais dinâmicas da ordem capitalista em expansão, apesar de seu baixo impacto na democratização do sistema de dominação nos dois contextos.In the paper, I compare some arguments about the social change developed by Florestan Fernandes and Gino Germani, protagonists of the renewal of sociology at the universities of Sao Paulo and Buenos Aires, respectively. Through empirical research, both sought to investigate how the modernization process differentially affected social groups, restoring durable patterns of inequality. Fernandes and Germani considered, moreover, the "immigrant" the main agent of the social changes underway, due to his successful insertion, in Sao Paulo and Buenos Aires, in the most dynamic positions of the capitalist order in expansion, despite his low impact on the democratization of the system of domination in both contexts.

  13. Examining Big Brother's Purpose for Using Electronic Performance Monitoring

    Science.gov (United States)

    Bartels, Lynn K.; Nordstrom, Cynthia R.

    2012-01-01

    We examined whether the reason offered for electronic performance monitoring (EPM) influenced participants' performance, stress, motivation, and satisfaction. Participants performed a data-entry task in one of five experimental conditions. In one condition, participants were not electronically monitored. In the remaining conditions, participants…

  14. The Mistreated Haiku and His Dizygotic Brother Senryu

    Science.gov (United States)

    Niece, Richard

    1978-01-01

    Haiku is a Japanese poem that deals with nature and contains seventeen syllables divided among three lines in the pattern of 5-7-5. Senryu is also a disciplined Japanese poem which deals directly with people and ideas. In Haiku, the reader utilizes imagination; in senryu, the interpretation has been supplied. Here are some creative suggestions for…

  15. Big Brother Is Watching: Video Surveillance on Buses

    Science.gov (United States)

    Sloggett, Joel

    2009-01-01

    Many school districts in North America have adopted policies to permit cameras on their properties and, when needed, on buses used to transport students. With regard to school buses, the camera is typically a tool for gathering information to monitor behavior or to help investigate a complaint about behavior. If a picture is worth a thousand…

  16. Brothers at War? Reflections on an Internecine Conflict between ...

    African Journals Online (AJOL)

    1999-01-08

    Jan 8, 1999 ... Using the Ethio-Eritrean conflict as a point of reference, this paper argues that such innovations are hobbled ... become a testing ground for innovations to the internationally hatched collective security. ..... informed such efforts, who were involved and in what capacity, and what their successes and failures.

  17. French physicist's brother denies links to Al Qaeda

    CERN Document Server

    Overbye, Dennis

    2009-01-01

    "Days after the French authorities placed a physicist working in Switzerland under formal investigation in a terror case, a portrait of the man and his work has begun to emerge from interviews with officials and his lawyer"

  18. Vennalik maja = A Brotherly House / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2002-01-01

    2001. a. Tallinnas Pirita teel valminud eramu projekteeris Arhitektibüroo Emil Urbel. Arhitektid Emil Urbel ja Indrek Erm, sisearhitekt Taso Mähar. Konstruktsioonid: E-Inseneribüroo. 5 ill.: korruste plaanid, sisevaade, välisvaated

  19. Alpha-fucosidosis – Two brothers presenting with dysostosis multiplex

    African Journals Online (AJOL)

    ... progressive neurological deterioration leading to early death. Definitive diagnosis requires a-fucosidase enzyme assay or FUCA1 gene testing, which being expensive limits the definitive diagnosis in resource limited countries. We present two siblings with classic symptoms, radiological and MRI brain findings suggestive ...

  20. Siblings of Oedipus: Brothers and Sisters of Incest Victims.

    Science.gov (United States)

    de Young, Mary

    1981-01-01

    Investigates the roles and problems of siblings of incest victims, describes the dynamics of the incestuous family, and identifies some behavior problems of children whose siblings were incest victims. Data from two siblings' lives are presented to illustrate points. (Author/DB)

  1. Deconstructing Gender and Sexuality Discourses in “Brothers For ...

    African Journals Online (AJOL)

    The campaign is an attempt to promote 'new' role models for South African men in order to get to grips with one of the most serious factors behind the spread of HIV/AIDS, namely male violence against women and children. The analysis suggests that past ideals of masculinity continue to find resonance in masculinities of ...

  2. Brothers at War? Reflections on an Internecine Conflict between ...

    African Journals Online (AJOL)

    This new thinking put sub-regional organisations like ECOWAS in West Africa and SADC in Southern Africa in a good stead to take this initiative. So far, however, such initiatives in these and other sub-regions have been fraught with problems most of them insurmountable. Using the Ethio-Eritrean conflict as a point of ...

  3. The three good brothers charm : some historical points / Lea Olsan

    Index Scriptorium Estoniae

    Olsan, Lea T.

    2011-01-01

    Ravimise loitsudest: keskajal levinud legendaarsest kolme venna (tres boni fratres - lad. k.) loitsust haava parandamiseks; ettekanne rahvusvahelisel konverentsil "Charms, charmers and charming" Bukarestis 2010. a.

  4. Am I My Brother's Keeper? On Personal Identity and Responsibility ...

    African Journals Online (AJOL)

    The psychological continuity theory of personal identity has recently been accused of not meeting what is claimed to be a fundamental requirement on theories of identity – to explain personal moral responsibility. Although they often have much to say about responsibility, the charge is that they cannot say enough. I set out ...

  5. The trials of brother Jero and the Island | Agoro | International ...

    African Journals Online (AJOL)

    This paper examines the interplay of the tripartite forces inherent in the creation of artistic works. It assumes that some playwrights derive the impetus for the creation of their works from the society and argues that creative works reflect the societies on which they are based. It explores the dualistic relationship between

  6. full on riot

    Directory of Open Access Journals (Sweden)

    Moses Iten

    2005-08-01

    Full Text Available “hey moses full on riot in lawson st the station’s on fire! been going since 4. molotov and more. full on,” reads an SMS message received on the backseat of a Tasmanian bus. What follows is a journey through the landscape of a Gunavidji, whose brothers have all gone to the land of the dead; metallic scraping in the glass cases of the Hobart Museum; a Palestinian woman giving up on her people; land-snails exposing cultural inaccuracies; photographing Australia’s war zone; entering the St Peter’s Basilica of Rome with bulldozers - all in the name of preparing to interview prominent Israeli writer Etgar Keret.

  7. Beyond Bad Behaving Brothers: Productive Performances of Masculinities among College Fraternity Men

    Science.gov (United States)

    Harris, Frank, III; Harper, Shaun R.

    2014-01-01

    Research on fraternity men focuses almost exclusively on problematic behaviors such as homophobia and sexism, alcohol abuse, violence against women, sexual promiscuity, and the overrepresentation of members among campus judicial offenders. Consequently, little is known about those who perform masculinities in healthy and productive ways. Presented…

  8. A designated centre for people with disabilities operated by Brothers of Charity Services South East, Waterford

    LENUS (Irish Health Repository)

    Walsh, Aisling

    2010-09-17

    Abstract Background Considerable attention has been given by policy makers and researchers to the human resources for health crisis in Africa. However, little attention has been paid to quantifying health facility-level trends in health worker numbers, distribution and workload, despite growing demands on health workers due to the availability of new funds for HIV\\/AIDS control scale-up. This study analyses and reports trends in HIV and non-HIV ambulatory service workloads on clinical staff in urban and rural district level facilities. Methods Structured surveys of health facility managers, and health services covering 2005-07 were conducted in three districts of Zambia in 2008 (two urban and one rural), to fill this evidence gap. Intra-facility analyses were conducted, comparing trends in HIV and non-HIV service utilisation with staff trends. Results Clinical staff (doctors, nurses and nurse-midwives, and clinical officers) numbers and staff population densities fell slightly, with lower ratios of staff to population in the rural district. The ratios of antenatal care and family planning registrants to nurses\\/nurse-midwives were highest at baseline and increased further at the rural facilities over the three years, while daily outpatient department (OPD) workload in urban facilities fell below that in rural facilities. HIV workload, as measured by numbers of clients receiving antiretroviral treatment (ART) and prevention of mother to child transmission (PMTCT) per facility staff member, was highest in the capital city, but increased rapidly in all three districts. The analysis suggests evidence of task sharing, in that staff designated by managers as ART and PMTCT workers made up a higher proportion of frontline service providers by 2007. Conclusions This analysis of workforce patterns across 30 facilities in three districts of Zambia illustrates that the remarkable achievements in scaling-up HIV\\/AIDS service delivery has been on the back of sustained non-HIV workload levels, increasing HIV workload and stagnant health worker numbers. The findings are based on an analysis of routine data that are available to district and national managers. Mixed methods research is needed, combining quantitative analyses of routine health information with follow-up qualitative interviews, to explore and explain workload changes, and to identify and measure where problems are most acute, so that decision makers can respond appropriately. This study provides quantitative evidence of a human resource crisis in health facilities in Zambia, which may be more acute in rural areas.

  9. Siblings: Brothers and Sisters of People Who Have Mental Retardation. Arc Q & A Series.

    Science.gov (United States)

    Arc, Arlington, TX.

    Basic information about siblings of people with mental retardation is presented in a question-and-answer format. The following questions are addressed: "Is having a sibling with a disability different than having a sibling who does not have a disability?"; "What are some of the concerns of siblings of people with disabilities?"; "Are there any…

  10. A designated centre for people with disabilities operated by Brothers of Charity Services Galway - Galway

    LENUS (Irish Health Repository)

    Golabek, Tomasz

    2013-07-22

    To compare urodynamic characteristics in patients with idiopathic detrusor overactivity (IDO) with those of an age matched cohort with diabetes mellitus (DM) and detrusor overactivity (DO). Secondly, to determine whether urodynamic features could help distinguish these two groups of patients.

  11. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    O'Shea, Eamon

    2011-02-14

    Abstract Background Current projections indicate that there will be a significant increase in the number of people with dementia in Ireland, from approximately 40,000 at present to 100,000 by 2036. Psychosocial interventions, such as reminiscence, have the potential to improve the quality of life of people with dementia. However, while reminiscence is used widely in dementia care, its impact on the quality of life of people with dementia remains largely undocumented and there is a need for a robust and fair assessment of its overall effectiveness. The DementiA education programme incorporating REminiscence for Staff study will evaluate the effectiveness of a structured reminiscence-based education programme for care staff on the quality of life of residents with dementia in long-stay units. Methods\\/Design The study is a two-group, single-blind cluster randomised trial conducted in public and private long-stay residential settings in Ireland. Randomisation to control and intervention is at the level of the long-stay residential unit. Sample size calculations suggest that 18 residential units each containing 17 people with dementia are required for randomisation to control and intervention groups to achieve power of at least 80% with alpha levels of 0.05. Each resident in the intervention group is linked with a nurse and care assistant who have taken the structured reminiscence-based education programme. Participants in the control group will receive usual care. The primary outcome is quality of life of residents as measured by the Quality of Life-AD instrument. Secondary outcomes include agitation, depression and carer burden. Blinded outcome assessment is undertaken at baseline and at 18-22 weeks post-randomisation. Discussion Trials on reminiscence-based interventions for people with dementia have been scarce and the quality of the information arising from those that have been done has been undermined by methodological problems, particularly in relation to scale and scope. This trial is powered to deliver more credible and durable results. The trial may also convey process utility to a long-stay system in Ireland that has not been geared for education and training, especially in relation to dementia. The results of this trial are applicable to long-stay residential units in Ireland and internationally. Trial registration Current Controlled Trials ISRCTN99651465

  12. Phelan-McDermid syndrome in two adult brothers: Atypical bipolar disorder as its psychopathological phenotype?

    NARCIS (Netherlands)

    W.M.A. Verhoeven (Wim); J.I.M. Egger (Jos); M.H. Willemsen; G.J.M. de Leijer (Gert); T. Kleefstra (Tjitske)

    2012-01-01

    textabstractThe 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. Its behavioral phenotype comprises sleep

  13. Phelan-McDermid syndrome in two adult brothers: Atypical bipolar disorder as its psychopathological phenotype?

    NARCIS (Netherlands)

    Verhoeven, W.M.A.; Egger, J.I.M.; Willemsen, M.H.; Leijer, G.J.M. de; Kleefstra, T.

    2012-01-01

    The 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. Its behavioral phenotype comprises sleep disturbances,

  14. Phelan-McDermid syndrome in two adult brothers: atypical bipolar disorder as its psychopathological phenotype?

    NARCIS (Netherlands)

    Verhoeven, W.M.; Egger, J.I.; Willemsen, M.H.; de Leijer, G.J.; Kleefstra, T.

    2012-01-01

    The 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. Its behavioral phenotype comprises sleep disturbances,

  15. Adjustment, Sibling Problems and Coping Strategies of Brothers and Sisters of Children with Autistic Spectrum Disorder

    Science.gov (United States)

    Ross, Penelope; Cuskelly, Monica

    2006-01-01

    Background: Siblings of children with autistic spectrum disorder (ASD) express more problem behaviours and experience more difficulties in their relationships than do children in families where all children are developing typically. We know little about what contributes to these difficulties. Method: Mothers of a child with ASD completed the…

  16. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Fogarty, Emer

    2014-09-01

    Multiple sclerosis (MS) has significant financial consequences for healthcare systems, individual patients and households, and the wider society. This study examines the distribution of MS costs and resource utilisation across cost categories and from various perspectives, as MS disability increases.

  17. Posterior Ankle Impingement in Two Athletic Twin Brothers, Could Genetics Play a Role?

    NARCIS (Netherlands)

    Bech, Niels H.; de Leeuw, Peter A. J.; Haverkamp, Daniel

    2016-01-01

    Pain posteriorly in the ankle can be caused by bony impingement of the posterolateral process of the talus. This process impinges between the tibia and calcaneus during deep forced plantar flexion. If this occurs it is called posterior ankle impingement syndrome. We report the case of 2 athletic

  18. My Brother’s Keeper: Forging SOF Operators Through Developmental Relationships

    Science.gov (United States)

    2016-06-01

    business-oriented literature focuses on examining the effects of mentoring, peer coaching, and developmental networks on career mobility and 5...figuring out the direction of the team. The pendulum has swung too far to one side. Where’s our focus? Regionally? Skill set? All that changes who you get...Relations, 66. Scandura, T. A. (1992). Mentorship and career mobility : An empirical investigation. Journal of Organizational Behavior, 13, 169–174

  19. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Holton, Alice E

    2017-11-08

    Older adults are particularly vulnerable to adverse effects from concurrent alcohol and medication use. However, there is limited evidence regarding the prevalence of these adverse outcomes among older adults, and there is a lack of consensus regarding what constitutes an alcohol-interactive medicine. The objective of this study was to develop an explicit list of potentially serious alcohol-medication interactions for use in older adults.

  20. Deconstructing gender and sexuality discourses in “Brothers for Life ...

    African Journals Online (AJOL)

    of social relations are relative to the spatial-temporal narrative envelope, and thus provides a means to discuss depictions of masculinity across time and space (Agha 2007). Importantly, the interpersonal experience of a chronotope and the way in which the personae in space-time are construed derive from the participation ...

  1. Back-breeding the aurochs: the Heck brothers, National Socialism and imagined geographies for nonhuman Lebensraum

    NARCIS (Netherlands)

    Driessen, C.P.G.; Lorimer, J.

    2016-01-01

    This chapter investigates the bio-geographical imaginations behind the animal 'back-breeding' programs carried out by Lutz and Heinz Heck - two influential German zoologists who ran Berlin and Munich zoos. Partly with close connections to and patronage from the National Socialist elite, the Heck

  2. A designated centre for people with disabilities operated by Brothers of Charity Services Limerick, Limerick

    LENUS (Irish Health Repository)

    O Caoimh, Rónán

    2014-09-19

    Functional decline and frailty are common in community dwelling older adults, increasing the risk of adverse outcomes. Given this, we investigated the prevalence of frailty-associated risk factors and their distribution according to the severity of perceived risk in a cohort of community dwelling older adults, using the Risk Instrument for Screening in the Community (RISC).

  3. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Clare

    LENUS (Irish Health Repository)

    1986-01-01

    Please note that this handbook was written in the 1990s and information may have been superceded with more recent publications. Please check the Alzheimer\\'s Society of Ireland website for the most up to date versions of documents. This document is made available here for achival purposes.

  4. When big brother is watching: goal orientation shapes reactions to electronic monitoring during online training.

    Science.gov (United States)

    Watson, Aaron M; Foster Thompson, Lori; Rudolph, Jane V; Whelan, Thomas J; Behrend, Tara S; Gissel, Amanda L

    2013-07-01

    Web-based training is frequently used by organizations as a convenient and low-cost way to teach employees new knowledge and skills. As web-based training is typically unproctored, employees may be held accountable to the organization by computer software that monitors their behaviors. The current study examines how the introduction of electronic performance monitoring may provoke negative emotional reactions and decrease learning among certain types of e-learners. Through motivated action theory and trait activation theory, we examine the role of performance goal orientation when e-learners are exposed to asynchronous and synchronous monitoring. We show that some e-learners are more susceptible than others to evaluation apprehension when they perceive their activities are being monitored electronically. Specifically, e-learners higher in avoid performance goal orientation exhibited increased evaluation apprehension if they believed asynchronous monitoring was present, and they showed decreased skill attainment as a result. E-learners higher on prove performance goal orientation showed greater evaluation apprehension if they believed real-time monitoring was occurring, resulting in decreased skill attainment. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  5. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon, Roscommon

    LENUS (Irish Health Repository)

    Ohmann, Christian

    2011-03-22

    Abstract Background A recent survey has shown that data management in clinical trials performed by academic trial units still faces many difficulties (e.g. heterogeneity of software products, deficits in quality management, limited human and financial resources and the complexity of running a local computer centre). Unfortunately, no specific, practical and open standard for both GCP-compliant data management and the underlying IT-infrastructure is available to improve the situation. For that reason the "Working Group on Data Centres" of the European Clinical Research Infrastructures Network (ECRIN) has developed a standard specifying the requirements for high quality GCP-compliant data management in multinational clinical trials. Methods International, European and national regulations and guidelines relevant to GCP, data security and IT infrastructures, as well as ECRIN documents produced previously, were evaluated to provide a starting point for the development of standard requirements. The requirements were produced by expert consensus of the ECRIN Working group on Data Centres, using a structured and standardised process. The requirements were divided into two main parts: an IT part covering standards for the underlying IT infrastructure and computer systems in general, and a Data Management (DM) part covering requirements for data management applications in clinical trials. Results The standard developed includes 115 IT requirements, split into 15 separate sections, 107 DM requirements (in 12 sections) and 13 other requirements (2 sections). Sections IT01 to IT05 deal with the basic IT infrastructure while IT06 and IT07 cover validation and local software development. IT08 to IT015 concern the aspects of IT systems that directly support clinical trial management. Sections DM01 to DM03 cover the implementation of a specific clinical data management application, i.e. for a specific trial, whilst DM04 to DM12 address the data management of trials across the unit. Section IN01 is dedicated to international aspects and ST01 to the competence of a trials unit\\'s staff. Conclusions The standard is intended to provide an open and widely used set of requirements for GCP-compliant data management, particularly in academic trial units. It is the intention that ECRIN will use these requirements as the basis for the certification of ECRIN data centres.

  6. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Ward, M

    2009-01-08

    In November and December 2008, six cases of suspect wound botulism were reported in heroin injecting drug users, all residents in Dublin, Ireland. Patients were aged between 23-42 years of age; four cases were male; one patient died shortly after admission. The patients presented to four different hospitals across the city. Botulism in injecting drug users in Ireland was last reported in 2002.

  7. An evaluation of the doctrine of miraculous healing within the Roman Catholic tradition / Brother James Scott

    OpenAIRE

    Scott, James

    2006-01-01

    According to biblical record, diseases and illness have troubled individuals almost since the beginning of creation (Wilkinson, 1998: 7). To understand and make sense of sickness, mankind turned to religion. In the Old Testament health is seen as a gift of God, but illness is perceived as a punishment for sin (Leon-Dufour, 1962: 543). The preaching of Job argues against this view. The problem of evil still causes difficulties for the Christian today. God permits such challen...

  8. Brothers or Rivals? Iran and the Shi'a of Iraq

    National Research Council Canada - National Science Library

    Hunter, Robert C

    2006-01-01

    This thesis examines the loyalty of the Shi a of Iraq. While some Sunni Arab leaders have recently accused the Shi a of Iraq of pledging loyalty to Iran, in fact the Iraqi Shi a are loyal to their own nation...

  9. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    O’Connell, Emer

    2016-07-01

    Patient safety requires optimal management of medications. Electronic systems are encouraged to reduce medication errors. Near field communications (NFC) is an emerging technology that may be used to develop novel medication management systems.

  10. Band of Brothers or Dysfunctional Family? A Military Perspective on Coalition Challenges During Stability Operations

    Science.gov (United States)

    2011-01-01

    was, in many cases, the commercial world’s managers and civilian economic geniuses who deserve much of the credit for success. Unfortu- nately, we do...conventional wartime combat, once the adversary has been defeated. Some erstwhile partners lack a unifying compulsion of suffi- cient importance to... card —i.e., refusing to obey due to the nation-specific caveat. Despite the NATO nations having worked together for many years, none suffered a

  11. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    O'Daly, Brendan J

    2009-06-01

    BACKGROUND: Predicting the clinical course in adhesional small bowel obstruction is difficult. There are no validated clinical or radiologic features that allow early identification of patients likely to require surgical intervention. METHODS: We conducted a retrospective review of 100 patients consecutively admitted to a tertiary level teaching hospital over a 3-year period (2002-2004) who had acute adhesional small bowel obstruction and underwent computed tomography (CT). The primary outcomes that we assessed were conservative management or the need for surgical intervention. We investigated time to physiologic gastrointestinal function recovery as a secondary outcome. We examined independent predictors of surgical intervention in a bivariate analysis using a stepwise logistic regression analysis. RESULTS: Of the 100 patients investigated, we excluded 12. Of the 88 remaining patients, 58 (66%) were managed conservatively and 30 (34%) underwent surgery. Peritoneal fluid detected on a CT scan (n = 37) was associated more frequently with surgery than conservative management (46% v. 29%, p = 0.046, chi(2)). Logistical regression identified peritoneal fluid detected on a CT scan as an independent predictor of surgical intervention (odds ratio 3.0, 95% confidence interval 1.15-7.84). CONCLUSION: The presence of peritoneal fluid on a CT scan in patients with adhesional small bowel obstruction is an independent predictor of surgical intervention and should alert the clinician that the patient is 3 times more likely to require surgery.

  12. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon, Roscommon

    LENUS (Irish Health Repository)

    O'Higgins, A

    2014-11-01

    The provision of high quality healthcare information about pregnancy is important to women and to healthcare professionals and it is 1 driven, in part, by a desire to improve clinical outcomes,. The objective of this study was to examine the use of digital media by women\\' to access pregnancy information. A questionnaire was distributed to women attending a large maternity hospital. Of the 522 respondents, the mean age was 31.8 years, 45% (235\\/522) were nulliparous, 62% (324\\/522) lived in the capital city and 29% (150\\/522) attended the hospital as private patients. Overall 95% (498\\/522) used the internet for pregnancy information, 76% (399\\/522) had a smartphone and 59% (235\\/399) of smartphone owners had used a pregnancy smartapp. The nature of internet usage for pregnancy information included discussion forums (70%), social networks (67%), video media (48%), e-books (15%), blogs (13%), microblogs (9%) and podcasts (4%). Even women who were socially disadvantaged reported high levels of digital media usage. In contemporary maternity care women use digital media extensively for pregnancy information. All maternity services should have a digital media strategy.

  13. TALKING POLITICS ONLINE WITHIN SPACES OF POPULAR CULTURE : THE CASE OF THE BIG BROTHER FORUM

    NARCIS (Netherlands)

    Graham, T.S.

    2010-01-01

    Talking politics online is not bound to spaces dedicated to politics, particularly the everyday political talk crucial to the public sphere. The aim of this article is to move beyond such spaces by examining political talk within a space dedicated to popular culture. The purpose is to see whether a

  14. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Murphy, Andrew W

    2005-07-29

    BACKGROUND: The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary heart disease (CHD) in general practice across two different health systems on the island of Ireland. CHD is a common cause of death and a significant cause of morbidity in Ireland. Secondary prevention has been recommended as a key strategy for reducing levels of CHD mortality and general practice has been highlighted as an ideal setting for secondary prevention initiatives. Current indications suggest that there is considerable room for improvement in the provision of secondary prevention for patients with established heart disease on the island of Ireland. The review literature recommends structured programmes with continued support and follow-up of patients; the provision of training, tailored to practice needs of access to evidence of effectiveness of secondary prevention; structured recall programmes that also take account of individual practice needs; and patient-centred consultations accompanied by attention to disease management guidelines. METHODS: SPHERE is a cluster randomised controlled trial, with practice-level randomisation to intervention and control groups, recruiting 960 patients from 48 practices in three study centres (Belfast, Dublin and Galway). Primary outcomes are blood pressure, total cholesterol, physical and mental health status (SF-12) and hospital re-admissions. The intervention takes place over two years and data is collected at baseline, one-year and two-year follow-up. Data is obtained from medical charts, consultations with practitioners, and patient postal questionnaires. The SPHERE intervention involves the implementation of a structured systematic programme of care for patients with CHD attending general practice. It is a multi-faceted intervention that has been developed to respond to barriers and solutions to optimal secondary prevention identified in preliminary qualitative research with practitioners and patients. General practitioners and practice nurses attend training sessions in facilitating behaviour change and medication prescribing guidelines for secondary prevention of CHD. Patients are invited to attend regular four-monthly consultations over two years, during which targets and goals for secondary prevention are set and reviewed. The analysis will be strengthened by economic, policy and qualitative components.

  15. 75 FR 46864 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Science.gov (United States)

    2010-08-04

    ... 9DZ Northern Ireland; telephone +44(0)2890-462469; fax +44(0)2890- 468444; e-mail michael.mulholland.... Revision History: PAD [proposed airworthiness directive] 06- 018R1 has been issued to endorse comments...

  16. Mothers' Differential Treatment of Adolescent Siblings: Predicting College Attendance of Sisters versus Brothers

    Science.gov (United States)

    Bissell-Havran, Joanna M.; Loken, Eric; McHale, Susan M.

    2012-01-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We…

  17. The zombie and his italian half brother: the satiric use of the zombie ...

    African Journals Online (AJOL)

    ... italiana degli anni Novanta, caratterizzata da un consumismo banale e popolata di giovani ossessionati dalla moda e dalla pubblicità. Il saggio si propone di analizzare il racconto nell'ambito del pulp italiano definendone le originali tecniche di demistificazione. Key Words: Pulp Fiction – Gothic Novel – Consumerism ...

  18. A designated centre for people with disabilities operated by Brothers of Charity Services South East, Waterford

    LENUS (Irish Health Repository)

    O'Reilly, Martina

    2016-07-01

    Assessment in palliative care settings should be focused, sensitive, specific, and effective to minimize discomfort to vulnerable and often highly morbid patients. This report describes the development of an admission assessment protocol for a Specialist Palliative Care Inpatient Unit and its implementation into clinical practice.

  19. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon, Roscommon

    LENUS (Irish Health Repository)

    Falush, Daniel

    2009-10-01

    Bacteria evolve rapidly in response to the environment they encounter. Some environmental changes are experienced numerous times by bacteria from the same population, providing an opportunity to dissect the genetic basis of adaptive evolution. Here I discuss two examples in which the patterns of rapid change provide insight into medically important bacterial phenotypes, namely immune escape by Neisseria meningitidis and host specificity of Campylobacter jejuni. Genomic analysis of populations of bacteria from these species holds great promise but requires appropriate concepts and statistical tools.

  20. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Limerick

    LENUS (Irish Health Repository)

    Hegarty, M

    2010-11-01

    As increasing demand for organs is a challenge for transplant services worldwide it is essential to audit the process of organ donation. To address this, a national audit of potential organ donors was undertaken across hospitals with Intensive Care Units (N = 36). Questionnaires were returned on all patients (n = 2073) who died in these units from 1\\/9\\/07-31\\/8\\/08; 200 (10%) of these patients were considered for Brain Stem Testing (BST), 158 patients (79%) were diagnosed Brain Stem Dead (BSD) and 138 patients (87%) became potential donors. Consent for donation was given by 92 (69%) next of kin and 90 potential donors (65%) became organ donors. There was no evidence of a large number of potential organ donors being missed. Recommendations included completion of BSTs on all appropriate patients, development of support on BST, referral of all BSD patients to the Organ Procurement Service; enhanced co-ordination within hospitals and sustained information\\/education campaigns.

  1. The Brothers and Sisters Learn To Write: Popular Literacies in Childhood and School Cultures.

    Science.gov (United States)

    Dyson, Anne Haas

    Building on the author's groundbreaking work in "Building Superheroes," this book traces the influence of a wide-ranging set of "textual toys" from children's lives--church and hip-hop songs, rap music, movies, TV, traditional jump-rope rhymes, the words of professional sports announcers and radio deejays--upon school learning…

  2. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    Clarke, Ciaran

    2015-05-01

    Among the core features of ASD, altered sensitivities in all modalities have been accorded increasing importance. Heightened sensitivity to pain and unusual expressions of and reaction to pain have not hitherto been widely recognised as a presenting feature of ASD in general paediatrics. Failure to recognise ASD as a common cause of pain can lead to late diagnosis, inappropriate treatment, distress, and further disability. Two cases are presented which illustrate the late presentation of Autism Spectrum Disorder (Asperger\\'s Syndrome subtype) with chronic unusual pain. Conclusion. Pain in autism can be atypical in its experience and expression and for this reason may go unrecognised by physicians treating chronic pain disorders.

  3. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    O'Caoimh, Rónán

    2015-09-01

    Few case-finding instruments are available to community healthcare professionals. This review aims to identify short, valid instruments that detect older community-dwellers risk of four adverse outcomes: hospitalisation, functional-decline, institutionalisation and death. Data sources included PubMed and the Cochrane library. Data on outcome measures, patient and instrument characteristics, and trial quality (using the Quality In Prognosis Studies [QUIPS] tool), were double-extracted for derivation-validation studies in community-dwelling older adults (>50 years). Forty-six publications, representing 23 unique instruments, were included. Only five were externally validated. Mean patient age range was 64.2-84.6 years. Most instruments n=18, (78%) were derived in North America from secondary analysis of survey data. The majority n=12, (52%), measured more than one outcome with hospitalisation and the Probability of Repeated Admission score the most studied outcome and instrument respectively. All instruments incorporated multiple predictors. Activities of daily living n=16, (70%), was included most often. Accuracy varied according to instruments and outcomes; area under the curve of 0.60-0.73 for hospitalisation, 0.63-0.78 for functional decline, 0.70-0.74 for institutionalisation and 0.56-0.82 for death. The QUIPS tool showed that 5\\/23 instruments had low potential for bias across all domains. This review highlights the present need to develop short, reliable, valid instruments to case-find older adults at risk in the community.

  4. A designated centre for people with disabilities operated by Brothers of Charity Services Limerick, Longford

    LENUS (Irish Health Repository)

    Masud, Tahir

    2014-09-01

    the rise in the number of older, frail adults necessitates that future doctors are adequately trained in the skills of geriatric medicine. Few countries have dedicated curricula in geriatric medicine at the undergraduate level. The aim of this project was to develop a consensus among geriatricians on a curriculum with the minimal requirements that a medical student should achieve by the end of medical school.

  5. Big Brother Is Helping You: Supporting Self-Access Language Learning with a Student Monitoring System

    Science.gov (United States)

    Reinders, Hayo

    2007-01-01

    Self-access and language advising are relatively recent and increasingly common types of language support offered in schools and tertiary institutions around the world. There is a great deal of anecdotal support for the positive contribution of such support to student learning. Self-access and language advising hold strong potential as…

  6. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Buckley, B S

    2011-12-12

    Background:  Gestational diabetes mellitus is a potentially serious condition that affects many pregnancies and its prevalence is increasing. Evidence suggests early detection and treatment improves outcomes, but this is hampered by continued disagreement and inconsistency regarding many aspects of its diagnosis. Methods:  The Vitamin D and Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) research programme aims to promote pan-European standards in the detection and diagnosis of gestational diabetes and to develop effective preventive interventions. To provide an overview of the context within which the programme will be conducted and its findings interpreted, systematic searching and narrative synthesis have been used to identify and review the best available European evidence relating to the prevalence of gestational diabetes, current screening practices and barriers to screening. Results:  Prevalence is most often reported as 2-6% of pregnancies. Prevalence may be lower towards the Northern Atlantic seaboard of Europe and higher in the Southern Mediterranean seaboard. Screening practice and policy is inconsistent across Europe, hampered by lack of consensus on testing methods, diagnostic glycaemic thresholds and the value of routine screening. Poor clinician awareness of gestational diabetes, its diagnosis and local clinical guidelines further undermine detection of gestational diabetes. Conclusions:  Europe-wide agreement on screening approaches and diagnostic standards for gestational diabetes could lead to better detection and treatment, improved outcomes for women and children and a strengthened evidence base. There is an urgent need for well-designed research that can inform decisions on best practice in gestational diabetes mellitus screening and diagnosis. © 2011 The Authors. Diabetic Medicine© 2011 Diabetes UK.

  7. Kaks kirja vennale = Two Letters from Vincent van Gogh to his brother / Vincent van Gogh

    Index Scriptorium Estoniae

    Gogh, Vincent van, 1853-1890

    2008-01-01

    Kunstnik Vincent van Goghi kaks kirja oma vennale Theole. Tõlge vene keelest ja kommentaar Mehis Heinsaarelt. Ingliskeelsed kirjad raamatust "The Complete Letters of Vincent van Gogh", Thames and Hudson, 1979

  8. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Lalor, Joan G

    2012-09-01

    Several authors have suggested that computer skills should be taught within the undergraduate curriculum. In this paper, the focus is mainly on the results of an examination of midwifery students\\' search strategy in response to a specific question undertaken before and after training session in the first, second and third years of the undergraduate programme.

  9. When Your Brother or Sister Has Cancer: A Guide for Teens

    Science.gov (United States)

    ... for you. It’s okay to talk about how hard it is and even cry together. ➜ Knowledge is power. It can help to learn more about cancer ... ... Others for Help You and your family may need support from others. It can be hard to ask. Yet most of the time people ...

  10. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Elmusharaf, Khalifa

    2015-09-01

    Universal health access will not be achieved unless women are cared for in their own communities and are empowered to take decisions about their own health in a supportive environment. This will only be achieved by community-based demand side interventions for maternal health access. In this review article, we highlight three common strategies to increase demand-side barriers to maternal healthcare access and identify the main challenges that still need to be addressed for these strategies to be effective.

  11. Figures from the air: the mediatised verbal performances of Laurie Anderson at Warner Brothers

    OpenAIRE

    Hunninghausen, Carlos Guilherme

    2002-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente. Esta pesquisa surgiu da observação de que no início deste novo século performances que circulam na mídia parecem Ter adquirido não somente mais prestígio cultural (tendo retirado do teatro muitos dos seus privilégios) como também maior impacto na economia de símbolos culturais que funciona no presente (Auslander) e examina uma...

  12. A designated centre for people with disabilities, operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Rock, Kathy

    2010-01-01

    ABSTRACT: INTRODUCTION: Hypercalcaemic hyperparathyroid crisis is a rare but life-threatening complication of primary hyperparathyroidism. Parathyroid carcinoma is a rare malignancy with an incidence of 0.5% to 4% of all reported cases of primary hyperparathyroidism. CASE PRESENTATION: We report the case of a 60-year-old Caucasian man with hypercalcaemic hyperparathyroid crisis associated with parathyroid carcinoma. He presented with a classic hypercalcaemic syndrome and his serum calcium and parathyroid hormone levels were at 4.65 mmol\\/L and 1743 ng\\/L, respectively. He initially presented with a two-week history of weakness and lethargy and a one-week history of vomiting, polyuria and polydipsia. An emergency left thyroid lobectomy and left lower parathyroidectomy were performed. There was a prompt decrease in his parathyroid hormone level immediately after surgery. Histology revealed that our patient had a 4-cm parathyroid carcinoma. CONCLUSION: In patients with parathyroid carcinoma, the optimal surgical treatment is en bloc resection with ipsilateral thyroid lobectomy and removal of any enlarged or abnormal lymph nodes. Surgery is the only curative treatment. In our patient, prompt surgical intervention proved successful. At six months the patient is well with no evidence of disease recurrence. This case highlights the importance of considering a hyperparathyroid storm in the context of a parathyroid carcinoma. Parathyroid carcinoma is a rare entity and our knowledge is mainly derived from case reports and retrospective studies. This case report increases awareness of this serious and life-threatening complication. This report also illustrates how prompt and appropriate management provides the best outcome for the patient.

  13. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Cornally, Nicola

    2015-11-01

    The \\'Let Me Decide\\' Advance Care Planning (LMD-ACP) programme offers a structured approach to End-of-Life (EoL) care planning in long-term care for residents with and without capacity to complete an advance care directive\\/plan. The programme was implemented in three homes in the South of Ireland, with a view to improving quality of care at end of life. This paper will present an evaluation of the systematic implementation of the LMD-ACP programme in the homes.

  14. Two brothers that don't look very similar; Zwei ungleiche Brueder

    Energy Technology Data Exchange (ETDEWEB)

    Jantzen, Markus

    2009-01-15

    At first glance, the Tesla Roadster and the Elektro-Smart seem to have nothing in common, apart from the fact that they are both electric vehicles. However, the comparison is not as foolish as it seems. (orig.)

  15. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon, Roscommon

    LENUS (Irish Health Repository)

    O'Reilly, Ken

    2015-07-10

    There is a broad literature suggesting that cognitive difficulties are associated with violence across a variety of groups. Although neurocognitive and social cognitive deficits are core features of schizophrenia, evidence of a relationship between cognitive impairments and violence within this patient population has been mixed.

  16. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Davoren, Mary

    2015-01-01

    Patients admitted to a secure forensic hospital are at risk of a long hospital stay. Forensic hospital beds are a scarce and expensive resource and ability to identify the factors predicting length of stay at time of admission would be beneficial. The DUNDRUM-1 triage security scale and DUNDRUM-2 triage urgency scale are designed to assess need for therapeutic security and urgency of that need while the HCR-20 predicts risk of violence. We hypothesized that items on the DUNDRUM-1 and DUNDRUM-2 scales, rated at the time of pre-admission assessment, would predict length of stay in a medium secure forensic hospital setting.

  17. Brothers or Rivals? Iran and the Shi’a of Iraq

    Science.gov (United States)

    2006-06-01

    369. 461 Juan Cole, “Iraq: All Together Against the Occupation,” Le Monde Diplomatique , May 2004, available at http://mondediplo.com/2004/05... Monde Diplomatique , May 2004. http://mondediplo.com/2004/05/03iraqinationalism. Accessed 12 June 2006. ______. “The Iraqi Shiites: On the History...06. http://www.juancole.com/2006_05_01_juancole_archive.html. Accessed 12 June 2006. _____. “Iraq: All Together Against the Occupation,” Le

  18. Band of Brothers - Warrior Ethos, Unit Effectiveness and the Role of Initial Entry Training

    National Research Council Canada - National Science Library

    Sando, Donald

    2004-01-01

    .... Integral to continued professionalism of the Army is developing cultural attitudes beliefs and behaviors of a Warrior Ethos the culture of disciplined initiative teamwork determination sacrifice...

  19. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Galway

    LENUS (Irish Health Repository)

    Shore, Anna C

    2012-10-01

    One hundred seventy-five isolates representative of methicillin-resistant Staphylococcus aureus (MRSA) clones that predominated in Irish hospitals between 1971 and 2004 and that previously underwent multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing were characterized by spa typing (175 isolates) and DNA microarray profiling (107 isolates). The isolates belonged to 26 sequence type (ST)-SCCmec types and subtypes and 35 spa types. The array assigned all isolates to the correct MLST clonal complex (CC), and 94% (100\\/107) were assigned an ST, with 98% (98\\/100) correlating with MLST. The array assigned all isolates to the correct SCCmec type, but subtyping of only some SCCmec elements was possible. Additional SCCmec\\/SCC genes or DNA sequence variation not detected by SCCmec typing was detected by array profiling, including the SCC-fusidic acid resistance determinant Q6GD50\\/fusC. Novel SCCmec\\/SCC composite islands (CIs) were detected among CC8 isolates and comprised SCCmec IIA-IIE, IVE, IVF, or IVg and a ccrAB4-SCC element with 99% DNA sequence identity to SCC(M1) from ST8\\/t024-MRSA, SCCmec VIII, and SCC-CI in Staphylococcus epidermidis. The array showed that the majority of isolates harbored one or more superantigen (94%; 100\\/107) and immune evasion cluster (91%; 97\\/107) genes. Apart from fusidic acid and trimethoprim resistance, the correlation between isolate antimicrobial resistance phenotype and the presence of specific resistance genes was ≥97%. Array profiling allowed high-throughput, accurate assignment of MRSA to CCs\\/STs and SCCmec types and provided further evidence of the diversity of SCCmec\\/SCC. In most cases, array profiling can accurately predict the resistance phenotype of an isolate.

  20. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Clare

    LENUS (Irish Health Repository)

    Kennedy, Harry G

    2011-09-01

    This series of rating \\'ladders\\' is intended to allow a quantitative and qualitative analysis of the use of restrictive and intrusive interventions as part of the therapeutic management of violence and aggression in psychiatric hospital settings. This is an evolving handbook. The ladders are currently organised to facilitate a behavioural analysis. Context, antecedents, behaviour, interventions, consequences are conceptualised as a series of events organised in temporal sequence so that causes, interactions and effects can be considered. The complexity of analysis possible is limited by the statistical power of the numbers of cases and events available. \\r\

  1. Sibling support : The exchange of help among brothers and sisters in the Netherlands

    NARCIS (Netherlands)

    Voorpostel, M.B.J.

    2007-01-01

    The bond with a sibling is potentially the longest lasting of all personal relationships. Siblings play a significant part in each other's lives over the entire life course. They are drawn together because they share a genetic, family, social class and historic background, but they are also

  2. Siblings’ experiences of having a brother or sister with an eating disorder: a qualitative exploration

    OpenAIRE

    Varnell, Catherine Jessica

    2014-01-01

    Background: Family members of people with eating disorders are often involved in caregiving. To better understand the impact on them, outcomes such as burden, distress, and less frequently quality of life (QoL) are taken into consideration. Despite advancements in the knowledge base surrounding the experiences of adult and parental caregivers of individuals with eating disorders, particularly Anorexia Nervosa, there is a scarcity of qualitative exploration from the sibling pers...

  3. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    Mokoka, Matshediso C

    2017-06-15

    Many patients with asthma remain poorly controlled despite the use of inhaled corticosteroids and long-acting beta agonists. Poor control may arise from inadequate adherence, incorrect inhaler technique or because the condition is refractory. Without having an objective assessment of adherence, clinicians may inadvertently add extra medication instead of addressing adherence. This study aims to assess if incorporating objectively recorded adherence from the Inhaler Compliance Assessment (INCA) device and lung function into clinical decision making provides more cost-effective prescribing and improves outcomes.

  4. First-person shooter games as a way of connecting to people: "brothers in blood".

    Science.gov (United States)

    Frostling-Henningsson, Maria

    2009-10-01

    This work seeks to understand young adults' motives for online gaming and extends previous research concerning social interaction in virtual contexts. The focus of the study is on Counter-Strike and World of Warcraft. Drawing on Baudrillard's concept of simulacra, an analysis of young gamers' motivation for gaming is carried out. The empirical data was generated employing a mix of qualitative methods such as researcher introspection, observation, and interviews with young adults in two different online gaming centers in Stockholm during 2006 and 2007. The results show that online gaming is foremost motivated by social reasons providing the gamers with a possibility of cooperation and communication. Some of the gamers in the study were motivated by escapism. Online gaming also provides gamers with an experience in which "flow" can be obtained and serves as a "hallucination of the real," making it possible to do things and try out behaviors that would be impossible to do or try in real life. The gamers felt that online gaming gave them more experiences than real life could provide. For research purposes, this work provides a better understanding of the motivational aspects for gamers.

  5. Modifiable environmental influences on body mass index shared by young adult brothers

    DEFF Research Database (Denmark)

    Rokholm, B; Silventoinen, K; Tynelius, P

    2013-01-01

    Twin and adoption studies suggest that family environment has little, if any, influence on body mass index (BMI) in adulthood. We investigated the hypothesis that the differences in the years of birth between siblings influence their similarity in BMI at comparable ages, which would give evidence...

  6. "Brother Where Art Thou?" African American Male Instructors' Perceptions of the Counselor Education Profession

    Science.gov (United States)

    Brooks, Michael; Steen, Sam

    2010-01-01

    The purpose of this study was to investigate the perceptions of African American male counselor educators regarding the limited number of African American male faculty members in counselor education. Implications and suggestions on how universities can recruit and retain African American male faculty members are provided.

  7. Power in Play: A Foucauldian Reading of A.O. Soyinka's "The Trials of Brother Jero"

    Science.gov (United States)

    Davoodifar, Mahboobeh; Asl, Moussa Pourya

    2015-01-01

    This work utilizes Foucault's articulations on the power strategies of our contemporary society. To him the subject's constitution is never a purely passive effect of power on the subject but requires the subject's own activity. This necessitates the existence of a dynamic, mutually affecting relationship, implying that one can be both dominated…

  8. Help a Brother Out: A Case Study in Multinational Intelligence Sharing, NATO SOF

    Science.gov (United States)

    2011-12-01

    timely 106 NSHQ COS briefing, October 20, 2010, and Alan Dron , “Special Network—Alliance Aims to Improve...BICES Communications & Information Systems Strategy, August 2011, 3, and Dron , “Special Network—Alliance Aims to Improve Cooperation among Special...and the Intelligence System.” International Journal of Intelligence and Counterintelligence 8, no. 4 (2005): 575–592. Dron , Alan. “Special Network

  9. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Casey, Jillian P

    2015-01-01

    Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterised by abnormal ciliary motion and impaired mucociliary clearance, leading to recurrent respiratory infections, sinusitis, otitis media and male infertility. Some patients also have laterality defects. We recently reported the identification of three disease-causing PCD genes in the Irish Traveller population; RSPH4A, DYX1C1 and CCNO. We have since assessed an additional Irish Traveller family with a complex phenotype involving PCD who did not have any of the previously identified PCD mutations.

  10. Rac1 and Rac3 in cell morphology and adhesion : brothers and foes

    NARCIS (Netherlands)

    Hajdo-Milašinović, A.

    2010-01-01

    Ondanks een hoge mate van homologie verschillen de kleine Rho GTPases Rac1 en Rac3 wezenlijk in de functie die ze uitoefenen. De beschreven verschillen in effecten op cell-matrix adhesie berust op het feit dat Rac1 en Rac3 onafhankelijk van elkaar en op een andere manier aan het multifunctionele

  11. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Prasad, Babu R

    2012-01-20

    Abstract Background The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid (TGA) capped CdTe QDs, were coated with a gelatine layer and investigated in this study with differentiated pheochromocytoma 12 (PC12) cells. The QD - cell interactions were investigated after incubation periods of up to 17 days by MTT and APOTOX-Glo Triplex assays along with using confocal microscopy. Results Long term exposure (up to 17 days) to gelatinated TGA-capped CdTe QDs of PC12 cells in the course of differentiation and after neurites were grown resulted in dramatically reduced cytotoxicity compared to non-gelatinated TGA-capped CdTe QDs. Conclusion The toxicity mechanism of QDs was identified as caspase-mediated apoptosis as a result of cadmium leaking from the core of QDs. It was therefore concluded that the gelatine capping on the surface of QDs acts as a barrier towards the leaking of toxic ions from the core QDs in the long term (up to 17 days).

  12. A designated centre for people with disabilities operated by Brothers of Charity Services South East, Tipperary

    LENUS (Irish Health Repository)

    Nicholl, Honor

    2014-04-01

    In 2010\\/12 an innovative children\\'s palliative care interprofessional educational project funded by the Irish Hospice Foundation was undertaken in a University faculty (Trinity College Dublin). This initiative responded to international educational recommendations to meet the palliative care needs of children. The project involved the development and delivery of 3 standalone modules at Master\\'s level and a substantive research evaluation of the project to examine stakeholders and students perspectives to provide an insight into their experiences and to gather data for future developments. The research evaluation was conducted in two parts, part one sought students\\' evaluation and part two sought stakeholders\\

  13. "The Two Brothers": Reconciling Perceptual-Cognitive and Statistical Models of Musical Evolution.

    Science.gov (United States)

    Jan, Steven

    2018-01-01

    While the "units, events and dynamics" of memetic evolution have been abstractly theorized (Lynch, 1998), they have not been applied systematically to real corpora in music. Some researchers, convinced of the validity of cultural evolution in more than the metaphorical sense adopted by much musicology, but perhaps skeptical of some or all of the claims of memetics, have attempted statistically based corpus-analysis techniques of music drawn from molecular biology, and these have offered strong evidence in favor of system-level change over time (Savage, 2017). This article argues that such statistical approaches, while illuminating, ignore the psychological realities of music-information grouping, the transmission of such groups with varying degrees of fidelity, their selection according to relative perceptual-cognitive salience, and the power of this Darwinian process to drive the systemic changes (such as the development over time of systems of tonal organization in music) that statistical methodologies measure. It asserts that a synthesis between such statistical approaches to the study of music-cultural change and the theory of memetics as applied to music (Jan, 2007), in particular the latter's perceptual-cognitive elements, would harness the strengths of each approach and deepen understanding of cultural evolution in music.

  14. From My Own Brother in My Own Home: Children's Experiences and Perceptions Following Alleged Sibling Incest.

    Science.gov (United States)

    Katz, Carmit; Hamama, Liat

    2015-08-30

    Sibling incest is an understudied field despite its high prevalence rates. The current study was designed to characterize the way children describe their experiences and perceptions following alleged sibling incest. The sample consisted of 20 forensic investigations with children who were referred to forensic investigation following suspected sibling incest. The age range of the children was between 6 and 12 years old, including 17 girls and three boys. Thematic analysis was conducted on all the interviews and the children's perceptions greatly echoed the ecological framework while they elaborated on three levels: family level, in which children discussed the context of the abuse and the disclosure; sibling level, in which children discussed their siblings' behaviors and the grooming process; and the child level, in which the children discussed their own behavior during the abuse. The discussion highlights the relevance of the ecological framework to the study's results and stresses the complexity of this phenomenon and the challenges it raises for practitioners in various contexts-child protective, forensic, and clinical. © The Author(s) 2015.

  15. Effects of Older Brother-Younger Sister Incest: A Study of the Dynamics of 17 Cases.

    Science.gov (United States)

    Laviola, Marisa

    1992-01-01

    This study of 17 cases of incest between siblings found the women commonly experienced mistrust of men and women, chronic low or negative self-esteem, sexual response difficulties, and intrusive thoughts of the incest. Individual therapy, talking with supportive family and friends, and validating themselves as victims were seen as helpful.…

  16. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Clare

    LENUS (Irish Health Repository)

    Surgenor, Paul Wg

    2015-01-01

    While most crisis intervention models adhere to a generalised theoretical framework, the lack of clarity around how these should be enacted has resulted in a proliferation of models, most of which have little to no empirical support. The primary aim of this research was to propose a suicide intervention model that would resolve the client\\'s suicidal crisis by decreasing their suicidal ideation and improve their outlook through enhancing a range of protective factors. The secondary aim was to assess the impact of this model on negative and positive outlook.

  17. "A Message for My Brother": The Vietnam Veterans' Memorial as Rhetorical Situation.

    Science.gov (United States)

    Carlson, A. Cheree; Hocking, John E.

    An examination of letters left at the Vietnam Veteran's Memorial in Washington, D.C. between November, 1984 and April, 1986 revealed that the memorial serves as a rhetorical situation that urges its visitors to eloquence. The memorial is an excellent proving ground for situational theory because the interaction of site and perception is vital to…

  18. A designated centre for people with disabilities operated by Brothers of Charity Services Clare, Clare

    LENUS (Irish Health Repository)

    O'Shea, E.

    2006-11-20

    Several instruments have been used to measure absorbed radiation dose under non-electronic equilibrium conditions, such as in the build-up region or near the interface between two different media, including the surface. Many of these detectors are discussed in this paper. A common method of measuring the absorbed dose distribution and electron contamination in the build-up region of high-energy beams for radiation therapy is by means of parallel-plate ionisation chambers. Thermoluminescent dosimeters (TLDs), diodes and radiographic film have also been used to obtain surface dose measurements. The diamond detector was used recently by the author in an investigation on the effects of beam-modifying devices on skin dose and it is also described in this report

  19. The Failure of Lehman Brothers and Merril Lynch: A Lesson for the ...

    African Journals Online (AJOL)

    Also the conventional lending procedures were not instituted rather they depend on subprime mortgage arrangement that did not have collateral securities. The declining home prices had made refinancing more difficult as a result of inadequate innovations in securitization. We therefore, recommended that the regulatory ...

  20. A designated centre for people with disabilities operated by Brothers of Charity Services South East, Tipperary

    LENUS (Irish Health Repository)

    Smart, Keith M

    2012-08-01

    As a mechanisms-based classification of pain \\'nociceptive pain\\' (NP) refers to pain attributable to the activation of the peripheral receptive terminals of primary afferent neurones in response to noxious chemical, mechanical or thermal stimuli. The symptoms and signs associated with clinical classifications of NP have not been extensively studied. The purpose of this study was to identify symptoms and signs associated with a clinical classification of NP in patients with low back (± leg) pain. Using a cross-sectional, between-subjects design; four hundred and sixty-four patients with low back (± leg) pain were assessed using a standardised assessment protocol after which their pain was assigned a mechanisms-based classification based on experienced clinical judgement. Clinicians then completed a clinical criteria checklist indicating the presence\\/absence of various symptoms and signs. A regression analysis identified a cluster of seven clinical criteria predictive of NP, including: \\'Pain localised to the area of injury\\/dysfunction\\

  1. Acid Brothers: Henry Beecher, Timothy Leary, and the psychedelic of the century.

    Science.gov (United States)

    Moreno, Jonathan D

    2016-01-01

    Henry Knowles Beecher, an icon of human research ethics, and Timothy Francis Leary, a guru of the counterculture, are bound together in history by the synthetic hallucinogen lysergic acid diethylamide (LSD). Both were associated with Harvard University during a critical period in their careers and of drastic social change. To all appearances the first was a paragon of the establishment and a constructive if complex hero, the second a rebel and a criminal, a rogue and a scoundrel. Although there is no evidence they ever met, Beecher's indirect struggle with Leary over control of the 20th century's most celebrated psychedelic was at the very heart of his views about the legitimate, responsible investigator. That struggle also proves to be a revealing bellwether of the increasingly formalized scrutiny of human experiments that was then taking shape.

  2. 77 FR 24554 - Culturally Significant Objects Imported for Exhibition; Determinations: “Quay Brothers: On...

    Science.gov (United States)

    2012-04-24

    ... display of the exhibit objects at The Museum of Modern Art, New York, NY, from on or about August 12, 2012... temporary exhibition within the United States, are of cultural significance. The objects are imported...

  3. 75 FR 12154 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Science.gov (United States)

    2010-03-15

    ...)2890-462469; fax +44(0)2890- 468444; e-mail [email protected] ; Internet http... docket on the Internet at http://www.regulations.gov ; or in person at the Docket Operations office... 2005/CPRO, www.easa.eu.int/home/cert_policy_statements_en.html ) that also included the EASA...

  4. A designated centre for people with disabilities operated by Brothers of Charity Services Limerick, Limerick

    LENUS (Irish Health Repository)

    Corcoran, Shane

    2012-07-18

    AbstractA 54 year old lady presented for routine excision of a scalp lesion thought clinically to represent a sebaceous cyst of the right occiput. 4 years earlier she underwent total abdominal hysterectomy and right salpingo-oophorectomy for 3 large uterine fibroids. Histo-pathological examination of the hysterectomy specimen revealed an incidental low-grade leiomyosarcoma. Staging imaging was negative for metastatic disease. She made an uneventful recovery and was treated further by adjuvant pelvic radiotherapy.She noticed an uncomfortable and unsightly cystic swelling on her occiput four years after hysterectomy and was referred for routine excision of what was believed to be a benign lesion. The lesion was excised and sent for histopathological examination. Microscopic analysis including immuno-histochemistry demonstrated an ER and PR positive metastatic deposit of leiomyosarcoma. The margins of excision were histologically clear of disease.At Multi-Disciplinary Team (MDT) discussion a diagnosis of metastatic scalp deposit from previous uterine leiomyosarcoma was made. Re-staging CT brain, thorax, abdomen and pelvis and MRI brain were negative for local recurrence or distant metastases. She is currently undergoing radiotherapy to the scalp and surrounding tissues and will be followed up closely by the involved teams.To the best of our knowledge, this is the first case described in the worldwide literature of isolated cutaneous metastasis to the scalp of uterine leiomyosarcoma without evidence of disseminated disease at other sites.Virtual slidesThe virtual slide(s) for this article can be found here: http:\\/\\/www.diagnosticpathology.diagnomx.eu\\/vs\\/1311834987345566.

  5. A designated centre for people with disabilities operated by Brothers of Charity Services Galway, Galway

    LENUS (Irish Health Repository)

    Daly, Louise

    2015-03-01

    This article reports on an evaluation of four family support programmes in Ireland for families of people with a physical or an intellectual disability or autism. The focus of the evaluation, which took place within a year of the programmes\\' completion, was on establishing whether the programmes had an impact on families\\' capacity to effectively support their family member.

  6. Who Will be My Brother's Keeper--My First Visit to Haiti

    Science.gov (United States)

    Tinker Sachs, Gertrude

    2013-01-01

    In this article, the author describes her preparations for the Teaching English to Speakers of Other Languages (TESOL) professional presentations in Haiti. As a cultural worker, (after Paulo Freire), she was very conscious of the need for care in working with "the Other" especially when the Other is known only from second hand…

  7. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon, Roscommon

    LENUS (Irish Health Repository)

    Murphy, Andrew W

    2005-07-29

    BACKGROUND: The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary heart disease (CHD) in general practice across two different health systems on the island of Ireland. CHD is a common cause of death and a significant cause of morbidity in Ireland. Secondary prevention has been recommended as a key strategy for reducing levels of CHD mortality and general practice has been highlighted as an ideal setting for secondary prevention initiatives. Current indications suggest that there is considerable room for improvement in the provision of secondary prevention for patients with established heart disease on the island of Ireland. The review literature recommends structured programmes with continued support and follow-up of patients; the provision of training, tailored to practice needs of access to evidence of effectiveness of secondary prevention; structured recall programmes that also take account of individual practice needs; and patient-centred consultations accompanied by attention to disease management guidelines. METHODS: SPHERE is a cluster randomised controlled trial, with practice-level randomisation to intervention and control groups, recruiting 960 patients from 48 practices in three study centres (Belfast, Dublin and Galway). Primary outcomes are blood pressure, total cholesterol, physical and mental health status (SF-12) and hospital re-admissions. The intervention takes place over two years and data is collected at baseline, one-year and two-year follow-up. Data is obtained from medical charts, consultations with practitioners, and patient postal questionnaires. The SPHERE intervention involves the implementation of a structured systematic programme of care for patients with CHD attending general practice. It is a multi-faceted intervention that has been developed to respond to barriers and solutions to optimal secondary prevention identified in preliminary qualitative research with practitioners and patients. General practitioners and practice nurses attend training sessions in facilitating behaviour change and medication prescribing guidelines for secondary prevention of CHD. Patients are invited to attend regular four-monthly consultations over two years, during which targets and goals for secondary prevention are set and reviewed. The analysis will be strengthened by economic, policy and qualitative components.

  8. A designated centre for people with disabilities operated by Brothers of Charity Services Clare

    LENUS (Irish Health Repository)

    O’Leary, B

    2016-02-01

    Vaginal bleeding is a common event in early pregnancy, with 20-40% of pregnancies affected. Prompt diagnosis and management of bleeding is important, both to reduce morbidity and to avoid excessive emotional distress. This was a prospective study of an educational programme aimed at Obstetrics and Gynaecology BST trainees in the National Maternity Hospital, Dublin. The educational programme consisted of didactic lectures, and simulation and practical sessions. A questionnaire reviewing early pregnancy complications was used to assess participant knowledge. Six trainees participated in the programme, with five (83%) answering the questionnaire. The pre-education questionnaire showed a generally poor level of knowledge of early pregnancy complications with 8\\/50 (16%) questions answered correctly. Following the educational intervention there was a statistically significant increase in participant knowledge with 45\\/50 (90%) questions answered correctly. A significant increase in participant knowledge of early pregnancy complications followed our multifaceted educational programme. Study limitations exist, however we have shown the potential value of our educational programme.

  9. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    Bennett, Annemarie E

    2014-08-06

    Adults with an intellectual disability have poorer diets than the general adult population. The Able 2 Cook 4 Health cookery course aims to improve the diets of adults with mild to moderate intellectual disability. This study aims to evaluate the course by obtaining the views of course participants and the views of managers hosting the course. Thirty course participants took part in focus groups. Five managers hosting the course participated in a semi-structured interview. Positive features of the course included the group cooking, social interaction and course instructors. Collaboration between centres hosting the course and participants\\' home environment is needed to help transfer the skills learned to all home settings. The Able 2 Cook 4 Health cookery course provided participants with an important social outlet to learn essential occupational skills. These findings could particularly influence the diets of adults with an intellectual disability moving into independent living.

  10. Brothers, Sisters and Fictive Kin: Communication about Sex among Urban Black Siblings

    Science.gov (United States)

    Wallace, Scyatta A.; Hooper, Lisa M.; Persad, Malini

    2014-01-01

    Siblings have been shown to influence youth substance use and violent behavior. However, limited research has examined sibling-influences on sexual activity, particularly among urban Black youth. The current qualitative research was an exploratory study to describe discussions among siblings about sex and sexual health. Individual interviews were…

  11. Ellis-van Creveld Syndrome: A Case Report of Two Brothers

    OpenAIRE

    Tibin K Baby; Rekha Krishna Pillai; PR Bindhu; Priya Thomas

    2016-01-01

    Ellis-van Creveld (EVC) syndrome is a rare genetic disorder with autosomal recessive transmission, clinically presenting as bilateral postaxial polydactyly, chondrodysplasia of long bones resulting in acromesomelic dwarfism and ectodermal dysplasia. Mutation in EVC1 and EVC2 gene located in a head to head configuration on chromosome 4p16 has been associ - ated with this syndrome. In Amish community of Pennsylvania, EVC prevalence rate is 1/5,000 and, in non-A...

  12. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon

    LENUS (Irish Health Repository)

    Carew, Rosemarie M.

    2010-07-06

    Abstract Background Male Irs2-\\/- mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2-\\/- mice. We identify retarded renal growth in male and female Irs2-\\/- mice, independent of diabetes. Results Kidney size and kidney:body weight ratio were reduced by approximately 20% in Irs2-\\/- mice at postnatal day 5 and was maintained in maturity. Reduced glomerular number but similar glomerular density was detected in Irs2-\\/- kidney compared to wild-type, suggesting intact global kidney structure. Analysis of insulin signalling revealed renal-specific upregulation of PKBβ\\/Akt2, hyperphosphorylation of GSK3β and concomitant accumulation of β-catenin in Irs2-\\/- kidney. Despite this, no significant upregulation of β-catenin targets was detected. Kidney-specific increases in Yes-associated protein (YAP), a key driver of organ size were also detected in the absence of Irs2. YAP phosphorylation on its inhibitory site Ser127 was also increased, with no change in the levels of YAP-regulated genes, suggesting that overall YAP activity was not increased in Irs2-\\/- kidney. Conclusions In summary, deletion of Irs2 causes reduced kidney size early in mouse development. Compensatory mechanisms such as increased β-catenin and YAP levels failed to overcome this developmental defect. These data point to Irs2 as an important novel mediator of kidney size.

  13. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    Reid, Angela

    2011-01-01

    Substantial progress has been made in the medical management of rheumatoid arthritis (RA) over the past decade with the introduction of biologic therapies, including anti-tumour necrosis factor alpha (anti-TNFα) therapy medications. However, individuals with RA taking anti-TNFα medication continue to experience physical, psychological and functional consequences, which could potentially benefit from rehabilitation. There is evidence that therapeutic exercise should be included as an intervention for people with RA, but to date there is little evidence of the benefits of therapeutic exercise for people with RA on anti-TNFα therapy medication. A protocol for a multicentre randomised controlled three-armed study which aims to examine the effect of dynamic group exercise therapy on land or in water for people with RA taking anti-TNFα therapy medication is described.

  14. Severe protein-calorie malnutrition in two brothers due to abuse by starvation.

    Science.gov (United States)

    Barroso, Marcela Montenegro Braga; Salvador, Luiza Martins; Fagundes Neto, Ulysses

    2016-12-01

    To describe the case of two siblings with severe protein-calorie malnutrition due to abuse by starvation. The two patients were simultaneously referred from the Municipal Hospital, where they were admitted to the Pediatric Gastroenterology clinic of a university hospital for diagnostic investigation of the cause of severe malnutrition and screening tests for Celiac Disease, Cystic Fibrosis and Environmental enteropathy among others. The exams were all normal, and after detailed research on the interactions of this family, we reached the conclusion that the malnutrition was due to abuse by starvation. The children spent approximately two months in the hospital, receiving a high-protein and high-calorie diet, with significant nutritional recovery. Abuse by starvation, although rare, should always be considered of as one of the causes of child malnutrition and pediatrician should be aware of the child's development, as well as the family interactions, to prevent more severe nutritional and emotional consequences in the future. Copyright © 2016. Publicado por Elsevier Editora Ltda.

  15. Family-focused prevention with Latinos: What about sisters and brothers?

    Science.gov (United States)

    Updegraff, Kimberly A; Umaña-Taylor, Adriana J; Rodríguez De Jesús, Sue A; McHale, Susan M; Feinberg, Mark F; Kuo, Sally I-Chun

    2016-08-01

    Using a randomized, intent-to-treat design, this pilot study examined the feasibility and short-term effects of Siblings Are Special ( SIBS ) with a sample of 54 low-income Latino families (91% Mexican-origin). Participants were older (M = 10.8 years; SD = .46) and younger siblings (M = 8.4 years; SD = 1.13), and their parents (94% biological mothers), who were randomly assigned within school to the intervention (n = 28) or no-attention control (n = 26) condition. The intervention condition included 12 weekly afterschool sessions (90 min each) for sibling pairs and 3 family nights for parents and siblings (2 hr each). SIBS was designed to enhance sibling relationships via 2 primary intervention targets: (a) children’s capacities that underlie positive sibling dynamics, including relationship skills, cognitions, and shared activities; and (b) parenting of siblings, specifically, enhancing positive guidance and involvement and discouraging authoritarian control. Pre- and posttest data were gathered from siblings and parents. Recruitment and implementation data revealed high rates of attendance and completion, and high ratings of parent satisfaction with the program. Further, analyses suggested the program had positive effects of small to modest magnitude on posttest measures of sibling and parent–child relationship quality, parenting of siblings, older siblings’ emotional efficacy, and parents’ depressive symptoms and parenting stress, controlling for pretest levels of all outcomes and family background characteristics. Discussion addresses the feasibility of sibling-focused programs with low-income Latino families and makes recommendations for future research. PsycINFO Database Record (c) 2016 APA, all rights reserved

  16. A designated centre for people with disabilities operated by Brothers of Charity Services Ireland, Clare

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    O'Rourke, Colm J

    2013-05-01

    Urological malignancies (cancers of the prostate, bladder, kidney and testes) account for 15% of all human cancers and more than 500,000 deaths worldwide each year. This group of malignancies is spread across multiple generations, affecting the young (testicular) through middle and old-age (kidney, prostate and bladder). Like most human cancers, urological cancers are characterized by widespread epigenetic insult, causing changes in DNA hypermethylation and histone modifications leading to silencing of tumor suppressor genes and genomic instability. The inherent stability yet dynamic plasticity of the epigenome lends itself well to therapeutic manipulation. Epigenetic changes are amongst the earliest lesions to occur during carcinogenesis and are essentially reversible (unlike mutations). For this reason, much attention has been placed over the past two decades on deriving pharmacological compounds that can specifically target and reverse such epi-mutations, either halting cancer on its developmental trajectory or reverting fully formed cancers to a more clinically manageable state. This review discusses DNA methyltransferase and histone deacetylase inhibitors that have been extensively studied in preclinical models and clinical trials for advanced and metastatic urological cancers.

  17. 76 FR 1985 - Airworthiness Directives; Short Brothers PLC Model SD3 Airplanes

    Science.gov (United States)

    2011-01-12

    ... those in the MCAI to ensure the AD is clear for U.S. operators and is enforceable in a U.S. court of law..., Belfast, BT3 9DZ Northern Ireland; telephone +44(0)2890-462469; fax +44(0)2890-468444; e-mail michael...

  18. What We Learn from Our Sisters and Brothers: For Better or for Worse

    Science.gov (United States)

    Kramer, Laurie; Conger, Katherine J.

    2009-01-01

    Siblings have considerable influence on one another's development throughout childhood, yet most human development research has neglected sibling socialization. Through this volume, we aim to enhance our understanding of how siblings play formative roles in one another's social and emotional development. We examine the mechanisms by which children…

  19. A designated centre for people with disabilities operated by Brothers of Charity Services Roscommon

    LENUS (Irish Health Repository)

    2012-05-23

    AbstractBackgroundRadiotherapy (RT) and androgen-deprivation therapy (ADT) are standard treatments for advanced prostate cancer (PC). Tumor vascularization is recognized as an important physiological feature likely to impact on both RT and ADT response, and this study therefore aimed to characterize the vascular responses to RT and ADT in experimental PC.MethodsUsing mice implanted with CWR22 PC xenografts, vascular responses to RT and ADT by castration were visualized in vivo by DCE MRI, before contrast-enhancement curves were analyzed both semi-quantitatively and by pharmacokinetic modeling. Extracted image parameters were correlated to the results from ex vivo quantitative fluorescent immunohistochemical analysis (qIHC) of tumor vascularization (9 F1), perfusion (Hoechst 33342), and hypoxia (pimonidazole), performed on tissue sections made from tumors excised directly after DCE MRI.ResultsCompared to untreated (Ctrl) tumors, an improved and highly functional vascularization was detected in androgen-deprived (AD) tumors, reflected by increases in DCE MRI parameters and by increased number of vessels (VN), vessel density ( VD), and vessel area fraction ( VF) from qIHC. Although total hypoxic fractions ( HF) did not change, estimated acute hypoxia scores ( AHS) – the proportion of hypoxia staining within 50 μm from perfusion staining – were increased in AD tumors compared to in Ctrl tumors. Five to six months after ADT renewed castration-resistant (CR) tumor growth appeared with an even further enhanced tumor vascularization. Compared to the large vascular changes induced by ADT, RT induced minor vascular changes. Correlating DCE MRI and qIHC parameters unveiled the semi-quantitative parameters area under curve ( AUC) from initial time-points to strongly correlate with VD and VF, whereas estimation of vessel size ( VS) by DCE MRI required pharmacokinetic modeling. HF was not correlated to any DCE MRI parameter, however, AHS may be estimated after pharmacokinetic modeling. Interestingly, such modeling also detected tumor necrosis very strongly.ConclusionsDCE MRI reliably allows non-invasive assessment of tumors’ vascular function. The findings of increased tumor vascularization after ADT encourage further studies into whether these changes are beneficial for combined RT, or if treatment with anti-angiogenic therapy may be a strategy to improve the therapeutic efficacy of ADT in advanced PC.

  20. A designated centre for people with disabilities operated by Brothers of Charity Services Limerick, Limerick

    LENUS (Irish Health Repository)

    Fang, Fang

    2009-09-01

    Commensal lactobacilli frequently produce bile salt hydrolase (Bsh) enzymes whose roles in intestinal survival are unclear. Twenty-six Lactobacillus salivarius strains from different sources all harbored a bsh1 allele on their respective megaplasmids. This allele was related to the plasmid-borne bsh1 gene of the probiotic strain UCC118. A second locus (bsh2) was found in the chromosomes of two strains that had higher bile resistance levels. Four Bsh1-encoding allele groups were identified, defined by truncations or deletions involving a conserved residue. In vitro analyses showed that this allelic variation was correlated with widely varying bile deconjugation phenotypes. Despite very low activity of the UCC118 Bsh1 enzyme, a mutant lacking this protein had significantly lower bile resistance, both in vitro and during intestinal transit in mice. However, the overall bile resistance phenotype of this and other strains was independent of the bsh1 allele type. Analysis of the L. salivarius transcriptome upon exposure to bile and cholate identified a multiplicity of stress response proteins and putative efflux proteins that appear to broadly compensate for, or mask, the effects of allelic variation of bsh genes. Bsh enzymes with different bile-degrading kinetics, though apparently not the primary determinants of bile resistance in L. salivarius, may have additional biological importance because of varying effects upon bile as a signaling molecule in the host.

  1. A designated centre for people with disabilities operated by Brothers of Charity Services South East, Waterford

    LENUS (Irish Health Repository)

    Barnett, Julie

    2011-05-13

    Abstract Background European consumers are faced with a myriad of food related risk and benefit information and it is regularly left up to the consumer to interpret these, often conflicting, pieces of information as a coherent message. This conflict is especially apparent in times of food crises and can have major public health implications. Scientific results and risk assessments cannot always be easily communicated into simple guidelines and advice that non-scientists like the public or the media can easily understand especially when there is conflicting, uncertain or complex information about a particular food or aspects thereof. The need for improved strategies and tools for communication about food risks and benefits is therefore paramount. The FoodRisC project ("Food Risk Communication - Perceptions and communication of food risks\\/benefits across Europe: development of effective communication strategies") aims to address this issue. The FoodRisC project will examine consumer perceptions and investigate how people acquire and use information in food domains in order to develop targeted strategies for food communication across Europe. Methods\\/Design This project consists of 6 research work packages which, using qualitative and quantitative methodologies, are focused on development of a framework for investigating food risk\\/benefit issues across Europe, exploration of the role of new and traditional media in food communication and testing of the framework in order to develop evidence based communication strategies and tools. The main outcome of the FoodRisC project will be a toolkit to enable coherent communication of food risk\\/benefit messages in Europe. The toolkit will integrate theoretical models and new measurement paradigms as well as building on social marketing approaches around consumer segmentation. Use of the toolkit and guides will assist policy makers, food authorities and other end users in developing common approaches to communicating coherent messages to consumers in Europe. Discussion The FoodRisC project offers a unique approach to the investigation of food risk\\/benefit communication. The effective spread of food risk\\/benefit information will assist initiatives aimed at reducing the burden of food-related illness and disease, reducing the economic impact of food crises and ensuring that confidence in safe and nutritious food is fostered and maintained in Europe.

  2. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    O'Neill, Sinéad M

    2017-02-27

    Caesarean section (CS) rates are increasing worldwide and as a result repeat CS is common. The optimal mode of delivery in women with one previous CS is widely debated and the risks to the infant are understudied. The aim of the current study was to evaluate if women with a trial of labour after caesarean (TOLAC) had an increased odds of neonatal and infant death compared to women with an elective repeat CS (ERCS).

  3. "[This] Book of Odd Tales/Which Transform the Brothers Grimm": Teaching Anne Sexton's "Transformations"

    Science.gov (United States)

    Keely, Karen A.

    2008-01-01

    Folklorist Andrew Lang, in his Preface to his 1910 edited collection "The Lilac Fairy Book", celebrates the ongoing repetition and retelling of fairy tales, including both the cozy retelling by the family fireplace. In the century since Lang wrote these words, many authors have joined the ranks of Shakespeare and Homer in putting fairy tale…

  4. Fatherhood in eighteenth-century Holland : The Van der Muelen brothers

    NARCIS (Netherlands)

    Roberts, B

    1996-01-01

    Until recently fatherhood in the Early Modem period has been largely unknown terrain. Books of advice on the physical upbringing of children were addressed to mothers, implying that fathers were not involved in the process. However iconographic evidence presented by Simon Schama suggests that

  5. Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.

    Science.gov (United States)

    Buchberger, Alexander; Bukau, Bernd; Sommer, Thomas

    2010-10-22

    In cells, both newly synthesized and pre-existing proteins are constantly endangered by misfolding and aggregation. The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging, pathological states, and even cell death. To avert these dangers, cells have developed powerful quality control strategies that counteract protein damage in a compartment-specific way. Here, we compare the protein quality control systems of the eukaryotic cytosol and the endoplasmic reticulum, focusing on the principles of damage recognition, the triage decisions between chaperone-mediated refolding and proteolytic elimination of damaged proteins, the repair of misfolded and aggregated protein species, and the mechanisms by which perturbations of protein homeostasis are sensed to induce compartment-specific stress responses. Copyright © 2010 Elsevier Inc. All rights reserved.

  6. A designated centre for people with disabilities operated by Brothers of Charity Southern Services, Cork

    LENUS (Irish Health Repository)

    2017-11-25

    Background: Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the \\'Demonstration of a study to Co-ordinate and Perform Human Biomonitoring on a European Scale\\' (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother\\/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents from families with lower educational attainment and in those exposed to such items as polyvinyl chloride (PVC), fast food and personal care products (PCP). Conclusions: The study demonstrates that human biomonitoring for assessing exposure to phthalates can be undertaken in Ireland and that the exposure of the population is widespread. Further work will be necessary before the consequences of this exposure are understood.

  7. Interdisciplinary Full Mouth Rehabilitation of a Patient with Amelogenesis Imperfecta: A Case Report with 8 Years Follow-up

    Science.gov (United States)

    Sreedevi, S; Sanjeev, R; Ephraim, Rena; Joseph, Mathai

    2014-01-01

    This case report deals with the interdisciplinary approach of a 28-year-old lady with Amelogenesis imperfecta of the hypoplastic kind. The patient came with a chief illness of worn out teeth, unsatisfactory esthetics and severe sensitivity of teeth. Her family history revealed a related situation in her father’s brother and her sister. On clinical assessment, the crowns of all teeth were worn out. The plan of the treatment was to protect as much tooth structure, restore the vertical dimension, and improve esthetics and masticatory function. The treatment procedures involved prosthodontic, endodontic, and periodontic interventions. After recording the vertical height, endodontic treatment and crown lengthening were performed with respect to the lower anteriors. The lost vertical height was regained in stages by insertion of full coverage crowns for all the teeth. The patient’s esthetic and functional needs were met with systematic and sequential interdisciplinary treatment approach. PMID:25628493

  8. The Impact of Siblings with Disabilities on Their Brothers and Sisters Pursuing a Career in Special Education

    Science.gov (United States)

    Marks, Susan Unok; Matson, Amy; Barraza, Lori

    2005-01-01

    It is well known that growing up with a sibling who has a disability has both positive and negative impacts on the non-disabled sibling (Beckman, 2002; Fisman, Wolf, Ellison, & Freeman, 2000; Gans, 1997; McHugh, 2003). In fact, the concern for ameliorating the potential negative impacts on nondisabled siblings has been a major impetus for the…

  9. A novel splice-site mutation in ATP6V0A4 gene in two brothers with ...

    Indian Academy of Sciences (India)

    ... Tunis El Manar, 1068 Tunis, Tunisia; Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Kallipoleos 75, 1678 Nicosia, Cyprus; Department of Pediatrics B, Children's Hospital of Tunis, Boulevard 9 avril, Bab Saadoun, Jabbary, ...

  10. Why Can't I Be More Like My Brother? The Role and Correlates of Sibling Social Comparison Orientation.

    Science.gov (United States)

    Jensen, Alexander C; Pond, Amanda M; Padilla-Walker, Laura M

    2015-11-01

    Siblings play an important role in relational and individual development throughout adolescence and beyond through several mechanisms. Central to this role and the mechanisms of sibling influence is the notion that siblings provide a constant and meaningful frame of reference for social comparison. This study examined the role of sibling social comparison orientation, or the tendency of siblings to compare themselves to one another, on youths' depressive symptoms and family relationships, both directly and by moderating links with parental differential treatment. Participants included 338 youth (M age = 18.34, SD = 1.03; 52 % female). Using hierarchical ordinary least squares regression, we found that a higher sibling social comparison orientation was linked with more depressive symptoms, warmer sibling relationships, and more sibling conflict. Additionally, sibling social comparison orientation moderated links of parental differential treatment with depressive symptoms and prosocial behavior toward family members such that effects were more salient for those with a high comparison orientation. The discussion focuses on the role of sibling comparison in the ways that siblings influence one another's development.

  11. Wright Brothers Lectureship in Aeronautics: Experience with HiMAT remotely piloted research vehicle - An alternate flight test approach

    Science.gov (United States)

    Deets, D. A.; Brown, L. E.

    1986-01-01

    The highly maneuverable aircraft technology (HiMAT) program explored the various and complex interactions of advanced technologies, such as aeroelastic tailoring, close-coupled canard, and relaxed static stability. A 0.44-subscale remotely piloted research vehicle (RPRV) of a hypothetical fighter airplane was designed and flight-tested to determine the effects of these interactions and to define the design techniques appropriate for advanced fighter technologies. Flexibility and high maneuverability were provided by flight control laws implemented in ground-based computers and telemetered to the vehicle control system during flight tests. The high quality of the flight-measured data and their close correlation with the analytical design modeling proved that the RPRV is a viable and cost-effective tool for developing aerodynamic, structure, and control law requirements for highly maneuverable fighter airplanes of the future.

  12. HOUSING AS AN EXPRESSION OF SELF-IDENTITY IN CONTEMPORARY ALGERIA: THE WORK OF EL-MINIAWY BROTHERS

    OpenAIRE

    Tahar Bellal

    2012-01-01

    This paper tries to shed light on post-traditional environment in Algeria in a post global civilisation era. Some chosen projects implemented in some parts of the country are dealt with in relation to the expression of self identity through housing architecture. The focus of the work is on methods, achievements and implications of the projects. As from the seventies of the last century Algeria witnessed dramatic changes in its physical environment. The cities became the focus of intern...

  13. A novel splice-site mutation in ATP6V0A4 gene in two brothers with ...

    Indian Academy of Sciences (India)

    2014-12-10

    Dec 10, 2014 ... ral hearing loss (SNHL) observed in patients with mutations in the ATP6V1B1 gene (Vargas-Poussou et al. 2006). Indeed,. Stover et al. (2002) demonstrated that young adult patients with ATP6V0A4 mutations could develop a mild SNHL in the long term (Stover et al. 2002). Some dRTA patients without. ∗.

  14. Agents of the Father's law in a society of brothers: A philosophic and psychoanalytic perspective on legitimate use of violence.

    Science.gov (United States)

    Even-Tzur, Efrat; Hadar, Uri

    This paper explores subjective processes of "Agents of Law" - individuals who the state grants the authority to use violence - and the dissonance stemming from the contradictory demands posed on them as legitimate users of violence despite the societal taboo against violence. A conceptual model will be offered based on two theoretical legs, Lacanian psychoanalysis and political theories of legitimacy. Specifically, psychoanalytic ideas would serve to examine unconscious processes, subject position and various identifications related to the question of "self-legitimacy" of Agents of Law. A central link between psychoanalysis and political thought is found in the image of the father and in the triad ruler-God-Father, which calls for an oedipal analysis. A psychoanalytic reading of two philosophical schools that elaborated on the question of legitimacy will be presented, and yield two analytic poles of a model for the understanding of possible subject positions of agents of Law: identification with a "Living Father" vs. identification with a "Dead Father". The psychoanalytic reading will shed light on the limitations of the philosophical perspectives in reflecting on the various (im)possible psychological positions of agents of Law. Finally, then, it will be shown how psychoanalysis helps finding words to characterize different nuances in the coping of agents of Law with the contradictory demands posed on them in an age in which God is dead, the father was murdered and the king was beheaded. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Leadership, Hermandad (Brother/Sisterhood), and Organizational Culture: Crossing Boundaries to Build Collaborative Relationships among Latino Fraternal Organizations

    Science.gov (United States)

    Heredia, Anna-Maria

    2013-01-01

    The purpose of the study is to explore the identity development and organizational culture of a student organization, the National Association of Latino Fraternal Organizations council (NALFO) by implementing a community of practice approach at a large, public university in southwestern United States. The objective is to construct a sustainable…

  16. Is schooling a family thing? Effects of grandparents, parents, brothers and sisters on the school choices of boys and girls

    NARCIS (Netherlands)

    Plug, E.J.S.

    1999-01-01

    There are various ways in which the family affects individual schooling decisions. To address these family forces at work, this paper asks whether parental human capital and parental income have distinct positive impacts on the childrens human capital formation. Estimates are presented that control

  17. The Antebellum American Textbook Authors' Populist History of Roman Land Reform and the Gracchi Brothers

    Science.gov (United States)

    McInnis, Edward

    2015-01-01

    This essay explores social and political values conveyed by nineteenth century world and universal history textbooks in relation to the antebellum era. These textbooks focused on the histories of ancient Greece and Rome rather than on histories of the United States. I argue that after 1830 these textbooks reinforced both the US land reform and the…

  18. Organic Solute Transporter-beta (SLC51B) Deficiency in Two Brothers with Congenital Diarrhea and Features of Cholestasis

    NARCIS (Netherlands)

    Sultan, Mutaz; Rao, Anuradha; Elpeleg, Orly; Vaz, Frédéric M.; Abu Libdeh, Bassam Y.; Karpen, Saul J.; Dawson, Paul A.

    2017-01-01

    Primary bile acid malabsorption (PBAM) is associated with congenital diarrhea, steatorrhea, and a block in the intestinal return of bile acids in the enterohepatic circulation. Mutations in the ileal Na(+) -dependent bile acid transporter (ASBT; SLC10A2) can cause PBAM, but do not appear to account

  19. Organic Solute Transporter-beta (SLC51B) Deficiency in Two Brothers with Congenital Diarrhea and Features of Cholestasis.

    Science.gov (United States)

    Sultan, Mutaz; Rao, Anuradha; Elpeleg, Orly; Vaz, Frédéric M; Abu Libdeh, Bassam Y; Karpen, Saul J; Dawson, Paul A

    2017-09-12

    Primary bile acid malabsorption (PBAM) is associated with congenital diarrhea, steatorrhea, and a block in the intestinal return of bile acids in the enterohepatic circulation. Mutations in the ileal Na + -dependent bile acid transporter (ASBT; SLC10A2) can cause PBAM, but do not appear to account for most familial cases. Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric Organic Solute Transporter alpha-beta (OSTα-OSTβ; SLC51A-SLC51B), which exports bile acid across the basolateral membrane. Here we report the first patients with OSTβ deficiency, clinically characterized by chronic diarrhea, severe fat soluble vitamin deficiency, and features of cholestatic liver disease including elevated serum gamma-glutamyltransferase activity. Whole exome sequencing revealed a homozygous single nucleotide deletion in codon 27 of SLC51B, resulting in a frameshift and premature termination at codon 50. Functional studies in transfected cells showed that the SLC51B mutation resulted in markedly reduced taurocholic acid uptake activity and reduced expression of the OSTα partner protein. The findings identify OSTβ deficiency as a new cause of congenital chronic diarrhea with features of cholestatic liver disease. These studies underscore OSTα-OSTβ's key role in the enterohepatic circulation of bile acids in humans. This article is protected by copyright. All rights reserved. © 2017 by the American Association for the Study of Liver Diseases.

  20. From Napoleon Conquests to the Big Brother Sabotage : Harmonization of the Dutch Historical Censuses in the Semantic Web

    NARCIS (Netherlands)

    Meroño-Peñuela, Albert; Ashkpour, Ashkan

    2014-01-01

    Around the turn of the 18th century, the first integral pop- ulation enumeration was held in the Netherlands during the Batavian Republic. It took over 30 years before the first official census was, by royal decree, organized and conducted in 1829, and was meant to be held from then onwards every

  1. Early 20th Century Education in the United States: The Role of the Brothers of Holy Cross

    Science.gov (United States)

    Armstrong, Philip C.

    2007-01-01

    The French Revolution bears an ironic responsibility for generating works of charity. To counteract the devastating social effects of that late 18th century uprising, numerous religious communities were founded in France, among them the Congregation of Holy Cross. The Congregation of Holy Cross, the founding religious community behind the…

  2. Who has demanded this plate? the history of meson mu o muon, the fat brother of the electron

    International Nuclear Information System (INIS)

    Boya, L.J.

    1997-01-01

    We retrace the discovery of the muon and stress its importance in the establishment of the standard model in particle physics. We remark the necessity of the existence of three families. At the end we speculate on some recent issues. (Author) 12 refs

  3. Observer variation in target volume delineation of lung cancer related to radiation oncologist-computer interaction: a 'Big Brother' evaluation.

    NARCIS (Netherlands)

    Steenbakkers, R.J.; Duppen, J.C.; Fitton, I.; Deurloo, K.E.; Zijp, L.; Uitterhoeve, A.L.; Rodrigus, P.T.; Kramer, G.W.P.M.; Bussink, J.; Jaeger, K. de; Belderbos, J.S.; Hart, A.A.M.; Nowak, P.J.; Herk, M. van; Rasch, C.R.

    2005-01-01

    BACKGROUND AND PURPOSE: To evaluate the process of target volume delineation in lung cancer for optimization of imaging, delineation protocol and delineation software. PATIENTS AND METHODS: Eleven radiation oncologists (observers) from five different institutions delineated the Gross Tumor Volume

  4. Intralocus sexual conflict in humans: Physically and hormonally masculine individuals have more attractive brothers relative to sisters

    NARCIS (Netherlands)

    Garver-Apgar, C.E; Heap, G.A.; Tybur, J.M.; Emery-Thompson, M.

    2011-01-01

    Intralocus sexual conflict (IASC) occurs when sex-specific selection favors genes that increase fitness in one sex and decrease fitness in the other sex. The current study was designed to explore whether IASC occurs in humans. In a sample of siblings, we identified and measured sexually dimorphic

  5. Ehlers danlos syndrome in two siblings

    Directory of Open Access Journals (Sweden)

    Das M

    2005-01-01

    Full Text Available Two cases of Ehlers-Danlos syndrome affecting two real brothers are being reported. Both of them presented with features of atrophy and hyperextensibility of skin, hypermobility of joints and scarring at the sites of trauma. The elder brother also had kyphoscoliosis and hypogonadism with testicular failure.

  6. Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation.

    Science.gov (United States)

    Urbizu, Aintzane; Cuenca-León, Ester; Raspall-Chaure, Miquel; Gratacòs, Margarida; Conill, Joan; Redecillas, Susana; Roig-Quilis, Manuel; Macaya, Alfons

    2010-08-15

    We report two monochorionic twins that progressively developed, between ages 5 and 10, a combination of episodic neurological disorders including paroxysmal exercise-induced dyskinesia, migraine without or with aura, absence seizures and writer's cramp. CSF/serum glucose ratio was moderately decreased in both patients. Mutational analysis of SLC2A1 gene identified a de novo heterozygous missense mutation in exon 4. This novel mutation has been previously showed to disrupt glucose transport in vitro. Both patients showed immediate and near-complete response to ketogenic diet. This clinical observation suggests that a high index of suspicion for GLUT1 deficiency syndrome is warranted in evaluating patients with multiple neurological paroxysmal events. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  7. A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections

    OpenAIRE

    Xu, Xiu; Xu, Qiong; Zhang, Ying; Zhang, Xiaodi; Cheng, Tianlin; Wu, Bingbing; Ding, Yanhua; Lu, Ping; Zheng, Jingjing; Zhang, Min; Qiu, Zilong; Yu, Xiang

    2012-01-01

    Abstract Background Autistic spectrum disorders (ASDs) are a family of neurodevelopmental disorders with strong genetic components. Recent studies have shown that copy number variations in dosage sensitive genes can contribute significantly to these disorders. One such gene is the transcription factor MECP2, whose loss of function in females results in Rett syndrome, while its duplication in males results in developmental delay and autism. Case presentation Here, we identified a Chinese famil...

  8. Deletion of UBE3A in brothers with Angelman syndrome at the breakpoint with an inversion at 15q11.2.

    Science.gov (United States)

    Kuroda, Yukiko; Ohashi, Ikuko; Saito, Toshiyuki; Nagai, Jun-Ichi; Ida, Kazumi; Naruto, Takuya; Wada, Takahito; Kurosawa, Kenji

    2014-11-01

    Angelman syndrome (AS) is characterized by severe intellectual disability with ataxia, epilepsy, and behavioral uniqueness. The underlining molecular deficit is the absence of the maternal copy of the imprinted UBE3A gene due to maternal deletions, which is observed in 70-75% of cases, and can be detected using fluorescent in situ hybridization (FISH) of the UBE3A region. Only a few familial AS cases have been reported with a complete deletion of UBE3A. Here, we report on siblings with AS caused by a microdeletion of 15q11.2-q12 encompassing UBE3A at the breakpoint of an inversion at 15q11.2 and 15q26.1. Karyotyping revealed an inversion of 15q, and FISH revealed the deletion of the UBE3A region. Array comparative genomic hybridization (CGH) demonstrated a 467 kb deletion at 15q11.2-q12, encompassing only UBE3A, SNORD115, and PAR1, and a 53 kb deletion at 15q26.1, encompassing a part of SLCO3A1. Their mother had a normal karyotype and array CGH detected no deletion of 15q11.2-q12, so we assumed gonadal mosaicism. This report describes a rare type of familial AS detected using the D15S10 FISH test. © 2014 Wiley Periodicals, Inc.

  9. L'utilisation des médias sociaux dans le monde du travail : l'employeur devient-il Big Brother ?

    OpenAIRE

    Dombrée, Pauline

    2016-01-01

    Ce mémoire porte sur l'utilisation des médias sociaux dans le monde du travail au travers de trois grands acteurs que sont : le travailleur, l'employeur et le recruteur. Master [120] en droit, Université catholique de Louvain, 2016

  10. Compatriots: Wendell Willkie, the Press, and the Cowles Brothers--An Introductory Survey, Including Willkie's "One World" Trip with Publisher Gardner (Mike) Cowles.

    Science.gov (United States)

    Strentz, Herbert

    By reviewing personal correspondence, biographies, newspaper coverage of the 1940s, and interviews, this survey examines Wendell Willkie's relations with the press in general and with publishers John Cowles and Gardner (Mike) Cowles in particular. Divided into four parts, the survey begins with a review of the correspondence between Willkie and…

  11. "When He's around His Brothers ... He's Not so Quiet": The Private and Public Worlds of School-Aged Children with Speech Sound Disorder

    Science.gov (United States)

    McLeod, Sharynne; Daniel, Graham; Barr, Jacqueline

    2013-01-01

    Children interact with people in context: including home, school, and in the community. Understanding children's relationships within context is important for supporting children's development. Using child-friendly methodologies, the purpose of this research was to understand the lives of children with speech sound disorder (SSD) in context.…

  12. “‘Need a Minister? How About Your Brother?’: The Universal Life Church between Religion and Non-Religion”

    OpenAIRE

    Hoesly, Dusty

    2015-01-01

    National media outlets have observed that weddings in the United States, especially for young educated people, are increasingly performed by ministers who are friends or relatives of the couple and who become ordained online just for that purpose. The primary organization licensing these ministers, and thus authorizing these weddings as legally valid, is the Universal Life Church (ULC), which has ordained over 20 million people since 1962. To date, there has been no focused study of the ULC o...

  13. 3-Methylcrotonyl-CoA carboxylase deficiency in an infant with cardiomyopathy, in her brother with developmental delay and in their asymptomatic father

    NARCIS (Netherlands)

    Visser, G; Suormala, T; Smit, GPA; Reijngoud, DJ; Bink-Boelkens, MTE; Niezen-Koning, KE; Baumgartner, ER

    2000-01-01

    Three affected members of one family, each with a different clinical presentation of isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase (MCC) deficiency are described. The index patient presented at 7 weeks of age with feeding difficulties, sweating and tachypnoea. Echocardiography showed a

  14. Primary diagnosis of multiple pheochromocytomas in the brother of a MEN-2 patient by simultaneous MIBG scintigraphy and low-dose computed tomography

    DEFF Research Database (Denmark)

    Kjaer, Andreas; Petersen, Claus Leth

    2002-01-01

    Metaiodobenzylguanidine (MIBG) scintigraphy is a well-established functional imaging method for localizing pheochromocytomas. However, the morphologic information revealed on the scintigram is often too sparse and thus, accordingly, supplemental computed tomography (CT) or magnetic resonance...... in both adrenal glands and one extra-adrenal pheochromocytoma located in the liver. The combined imaging ensured the final diagnosis without any need for further imaging. Based on the findings of this case, the authors believe that combined MIBG scintigraphy and low-dose CT is a promising future single...

  15. 'He is now like a brother, I can even give him some blood'--relational ethics and material exchanges in a malaria vaccine 'trial community' in The Gambia.

    Science.gov (United States)

    Geissler, P Wenzel; Kelly, Ann; Imoukhuede, Babatunde; Pool, Robert

    2008-09-01

    This paper explores social relations within the 'trial community' (staff and volunteers) of a Malaria Vaccine Trial (MVT), implemented by the Medical Research Council (MRC) in The Gambia between 2001 and 2004. It situates ethical concerns with medical research within the everyday life of scientific fieldwork. Based upon discussions with volunteers and staff, we explore processes of mediation between scientific project and study population, and between formal ethics, local ethical debates and everyday practice. We observe that material contact and substantial transactions, notably of blood and medicine, are central to the construction of the MVT. These transactions are guided by a concrete and relational form of ethics, which contrasts with the abstract and vertical formal ethical principles underwriting the scientific study protocol. The success of the MVT owed much to these kinship-like ethics. One possible conclusion from these observations is that research ethics should be understood, not just as a quasi-legal frame but also as an open, searching movement, much in the same way that kinship is not merely a juridical institution and a prescriptive frame of rules, but a network made through relational work. However, this conclusion raises new problems: by contrasting formal, abstract principles to intimate, immediate relations, and economic justice to personal morality, we accept that the order of medical research is moved further out of the public and political, and into the domains of either quasi-legal claims or of private morality. Irrespective of the undeniable importance of clear-cut rules and of good face-to-face relations, a third essential foundation of medical research ethics is the democratically constituted public sphere, including equitable health services, and transparent institutions to facilitate open debate and regulate particular interests. Ultimately, the ethics of global science can rely neither on principles nor trust but requires citizenship and democratic government.

  16. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... MRI Story Video: Abdominal Ultrasound Video: Pelvic Ultrasound Medical Imaging Costs Radiology and You Take our survey ... oncologist at the Cancer Institute at Alexian Brothers Medical Center in Elk Grove Village, Illinois. I’d ...

  17. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... org Hello! I’m Dr. Ramji Rajendran, a radiation oncologist at the Cancer Institute at Alexian Brothers ... of radiotracer used is small, the level of radiation exposure is relatively low and the benefit of ...

  18. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Carotid Intima-Media Thickness ... Dr. Ramji Rajendran, a radiation oncologist at the Cancer Institute at Alexian Brothers Medical Center in Elk ...

  19. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: How to Obtain and ... Dr. Ramji Rajendran, a radiation oncologist at the Cancer Institute at Alexian Brothers Medical Center in Elk ...

  20. Your Radiologist Explains Nuclear Medicine

    Medline Plus

    Full Text Available ... Index A-Z Spotlight March is National Colorectal Cancer Awareness Month Recently posted: Video: The Basketball Game: ... Dr. Ramji Rajendran, a radiation oncologist at the Cancer Institute at Alexian Brothers Medical Center in Elk ...

  1. Topical Cidofovir for Recalcitrant Verrucae in Individuals with Severe Combined Immunodeficiency After Hematopoietic Stem Cell Transplantation.

    Science.gov (United States)

    Henrickson, Sarah E; Treat, James R

    2017-01-01

    Verrucae vulgaris in patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HCST) can be challenging to manage. We describe two brothers with X-linked SCID who had severe, persistent verrucae that did not respond to traditional topical therapies, including liquid nitrogen, imiquimod, salicylic acid, sinecatechins, 40% urea, and 5-fluorourcil. Both brothers had full response to topical 3% cidofovir, which should be considered in recalcitrant warts in individuals with SCID after HSCT. © 2016 Wiley Periodicals, Inc.

  2. Genomic selection in a pig population including information from slaughtered full sibs of boars within a sib-testing program.

    Science.gov (United States)

    Samorè, A B; Buttazzoni, L; Gallo, M; Russo, V; Fontanesi, L

    2015-05-01

    Genomic selection is becoming a common practise in dairy cattle, but only few works have studied its introduction in pig selection programs. Results described for this species are highly dependent on the considered traits and the specific population structure. This paper aims to simulate the impact of genomic selection in a pig population with a training cohort of performance-tested and slaughtered full sibs. This population is selected for performance, carcass and meat quality traits by full-sib testing of boars. Data were simulated using a forward-in-time simulation process that modeled around 60K single nucleotide polymorphisms and several quantitative trait loci distributed across the 18 porcine autosomes. Data were edited to obtain, for each cycle, 200 sires mated with 800 dams to produce 800 litters of 4 piglets each, two males and two females (needed for the sib test), for a total of 3200 newborns. At each cycle, a subset of 200 litters were sib tested, and 60 boars and 160 sows were selected to replace the same number of culled male and female parents. Simulated selection of boars based on performance test data of their full sibs (one castrated brother and two sisters per boar in 200 litters) lasted for 15 cycles. Genotyping and phenotyping of the three tested sibs (training population) and genotyping of the candidate boars (prediction population) were assumed. Breeding values were calculated for traits with two heritability levels (h 2=0.40, carcass traits, and h 2=0.10, meat quality parameters) on simulated pedigrees, phenotypes and genotypes. Genomic breeding values, estimated by various models (GBLUP from raw phenotype or using breeding values and single-step models), were compared with the classical BLUP Animal Model predictions in terms of predictive ability. Results obtained for traits with moderate heritability (h 2=0.40), similar to the heritability of traits commonly measured within a sib-testing program, did not show any benefit from the

  3. Supplementary analyses regarding Langevin, Langevin, and Curnoe's (2007) findings on fraternal birth order in homosexual men.

    Science.gov (United States)

    Blanchard, Ray

    2007-08-01

    A recent article by Langevin, Langevin, and Curnoe (2007) reported mixed results regarding the fraternal birth order effect, that is, the repeatedly observed finding that older brothers correlate with homosexuality in later-born males. Using a fraternal birth order index computed as older brothers minus younger brothers, Langevin et al. found that the "homoerotic" probands were born later among their brothers than were the "heteroerotic" probands in their full sample (N = 1194) and in their subsample over age 19 (N = 1122), but not in their subsample over age 31 (N = 698) or in their subsample with mothers over age 46 at the proband's birth (N = 727). The present writer concluded that the results obtained with the larger samples are more reliable, based on analyses demonstrating that (1) the larger samples are unlikely to be seriously affected by incomplete sibships, and (2) the smaller samples have poor statistical power. A separate analysis, based on an approximate reconstruction of Langevin et al.'s raw data, indicated that their heteroerotic probands reported a ratio of 104 older brothers per 100 older sisters, which is close to the normative population value of 106, whereas their homoerotic probands reported a ratio of 137, indicating a statistically significant excess of older brothers. These results suggest that Langevin et al.'s data showed significant evidence of a fraternal birth order effect and that their data were consistent with previous studies of this phenomenon.

  4. Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210A/A prothrombin mutation and heterozygous 1691G/A factor V Leiden mutation.

    Science.gov (United States)

    Halbmayer, W M; Kalhs, T; Haushofer, A; Breier, F; Fischer, M

    1999-07-01

    We report on members of a Turkish thrombophilic family with coinheritance of the prothrombin mutation PT20210A and the factor V Leiden mutation. The 23-year-old propositus and his elder sister both had episodes of venous theomboembolism at a young age (23 years and 26 years, respectively) and are homozygous for the PT20210A mutation and heterozygous for the factor V Leiden mutation. The 51-year-old father is suffering from coronary heart disease and is heterozygous for both thrombophilic mutations. The asymptomatic 43-year-old mother is heterozygous for the PT20210A mutation, but without activated protein C resistance. Two other children, a 20-year-old girl who is homozygous for the PT20210A mutation and a 13-year-old boy who is heterozygous for the PT20210A mutation, are both free from activated protein C resistance and thrombosis. This report provides further evidence for an early onset of thromboembolic disorders in individuals with an homozygous state of the prothrombin variant 20210A/A and coinheritance of another thrombophilic mutation. Consensus guidelines are required for the treatment and prophylaxis of patients and subjects who remain asymptomatic with homozygous or more than one heterozygous genetic defect associated with thrombophilia.

  5. Sequence divergence and loss-of-function phenotypes of S locus F-box brothers genes are consistent with non-self recognition by multiple pollen determinants in self-incompatibility of Japanese pear (Pyrus pyrifolia).

    Science.gov (United States)

    Kakui, Hiroyuki; Kato, Masaki; Ushijima, Koichiro; Kitaguchi, Miyoko; Kato, Shu; Sassa, Hidenori

    2011-12-01

    The S-RNase-based gametophytic self-incompatibility (SI) of Rosaceae, Solanaceae, and Plantaginaceae is controlled by at least two tightly linked genes located at the complex S locus; the highly polymorphic S-RNase for pistil specificity and the F-box gene (SFB/SLF) for pollen. Self-incompatibility in Prunus (Rosaceae) is considered to represent a 'self recognition by a single factor' system, because loss-of-function of SFB is associated with self-compatibility, and allelic divergence of SFB is high and comparable to that of S-RNase. In contrast, Petunia (Solanaceae) exhibits 'non-self recognition by multiple factors'. However, the distribution of 'self recognition' and 'non-self recognition' SI systems in different taxa is not clear. In addition, in 'non-self recognition' systems, a loss-of-function phenotype of pollen S is unknown. Here we analyze the divergence of SFBB genes, the multiple pollen S candidates, of a rosaceous plant Japanese pear (Pyrus pyrifolia) and show that intrahaplotypic divergence is high and comparable to the allelic diversity of S-RNase while interhaplotypic divergence is very low. Next, we analyzed loss-of-function of the SFBB1 type gene. Genetic analysis showed that pollen with the mutant haplotype S(4sm) lacking SFBB1-S(4) is rejected by pistils with an otherwise compatible S(1) while it is accepted by other non-self pistils. We found that the S(5) haplotype encodes a truncated SFBB1 protein, even though S(5) pollen is accepted normally by pistils with S(1) and other non-self haplotypes. These findings suggest that Japanese pear has a 'non-self recognition by multiple factors' SI system, although it is a species of Rosaceae to which Prunus also belongs. © 2011 The Authors. The Plant Journal © 2011 Blackwell Publishing Ltd.

  6. If three of my brothers have ankylosing spondylitis, why does the doctor say it is not necessarily hereditary? The meaning of risk in multiplex case families with ankylosing spondylitis.

    Science.gov (United States)

    Peláez-Ballestas, Ingris; Romero-Mendoza, Martha; Burgos-Vargas, Rubén

    2016-03-01

    To investigate how patients with ankylosing spondylitis and their relatives in multiplex case families understand concepts of familial aggregation, heredity and risk perceptions, and its impact on decision-making. This is a multimethod clinical investigation using field research style in 34 individuals from 10 families with ≥2 members with ankylosing spondylitis covering a wide spectrum of disease severity, educational level, and economical status. The narratives of patients and their relatives were obtained using clinical information, unstructured observation, and personal interviews, which were then transcribed verbatim, coded, and analyzed by three investigators. The interpretation of the textual data was based on two analysis styles, immersion/crystallization and interpretative grounded theory. We identified four broad interrelated interpretive units in patient and relatives narratives: (1) familial interpretation of the disease, (2) genetic risk, (3) decision-making based on risk, and (4) patient-family/physician discourse contradiction on the meaning of heredity. Patient's and their relatives interpretation of familial aggregation, HLAB27, heredity, and risk perception in relation with ankylosing spondylitis involves four broad interpretive units spanning from clinical symptoms to heredity and decisions made accordingly. Their thoughts and consequent decisions are often in contradiction with the medical knowledge on the role of genetic factors in ankylosing spondylitis. © The Author(s) 2015.

  7. "I Am Becoming More and More Like My Eldest Brother!": The Relationship Between Older Siblings, Adolescent Gambling Severity, and the Attenuating Role of Parents in a Large-Scale Nationally Representative Survey Study.

    Science.gov (United States)

    Canale, Natale; Vieno, Alessio; Griffiths, Mark D; Siciliano, Valeria; Cutilli, Arianna; Molinaro, Sabrina

    2017-06-01

    The present study examined the association between having older siblings who gamble and adolescent at-risk/problem gambling and how parents (i.e., parental knowledge of their whereabouts) and peers might moderate such effects. Data were drawn from the ESPAD ® Italia2012 survey (European School Survey Project on Alcohol and Other Drugs) comprising a nationally representative Italian sample of adolescents. The analysis was carried out on a subsample of 10,063 Italian students aged 15-19 years (average age = 17.10; 55 % girls) who had at least one older sibling and who had gambled at some point in their lives. Respondents' problem gambling severity, older gambler sibling, gambler peers, parental knowledge, and socio-demographic characteristics were individually assessed. Multinomial logistic regression analyses including two- and three-way interactions were conducted. The odds of being an at-risk/problem gambler were higher among high school students with older siblings that gambled and those with peers who gambled. Higher parental knowledge (of who the adolescent was with and where they were in their leisure time) was associated with lower rates of at-risk/problem gambling. There was also an interaction between gamblers with older siblings and parental knowledge. The combination of having siblings who gambled and a greater level of parental knowledge was associated with lower levels of problem gambling. The present study confirmed the occurrence of social risk processes (older siblings and peers who gambled) and demonstrated that gambling among older siblings and peers represents an important contextual factor for increased at-risk/problem gambling. However, parental knowledge appears to be sufficient to counterbalance the influence of older siblings.

  8. 20 CFR 633.320 - Nepotism.

    Science.gov (United States)

    2010-04-01

    ... family” means wife, husband, son, daughter, mother, father, brother, brother-in-law, sister, sister-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew, stepparent...

  9. South African Journal of Philosophy - Vol 32, No 1 (2013)

    African Journals Online (AJOL)

    Am I My Brother's Keeper? On Personal Identity and Responsibility · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL ... Is the Choice on Termination of Pregnancy Act Guilty of Disability Discrimination? EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. S Hall, 36-46.

  10. Celebrating a Century of Flight

    Science.gov (United States)

    2002-01-01

    The history of aviation is briefly covered in this publication, with sections on the Wright brothers, the balloons of the Montgolfier brothers, other early aviation pioneers before the Wright brothers, the role of aircraft in the world wars, air mail, Charles Lindbergh, women aviators, the jet age, and the space age, among other topics.

  11. The Role of Family Background for Earnings in Rural China

    DEFF Research Database (Denmark)

    Eriksson, Tor Viking; Qiang, Zhang Ying

    This paper provides estimates of brother income correlations for rural China. Brother correlations are a parsimonious measure of the importance of family and community background as determinants of individuals' economic status. We find internationally high levels of income similarity for brothers...

  12. Reframing Paul's sibling language in light of Jewish epistolary forms ...

    African Journals Online (AJOL)

    2015-06-17

    Jun 17, 2015 ... smart phone or mobile device to read online. Introduction. Scholars have predominantly focused on the usage of 'brothers' or 'brother' in light of the Greco-. Roman epistolary conventions and cultural .... So, 'a brother' is distinct from a foreigner and may signify shared nationality or heritage which in the.

  13. An unusual occurrence of repeated single allele variation on Y-STR locus DYS458

    Directory of Open Access Journals (Sweden)

    Pankaj Shrivastava

    2016-09-01

    Full Text Available Six brothers were accused of gagging and raping a woman. A single male Y-STR profile was obtained from vaginal smear swab and clothes of the victim, which did not match with the DNA profile of the accused brothers. As a reference point, the blood sample of their father (aged 87 years was also analyzed with the same kit. The Y-STR haplotype of all six brothers was found to be the same as that of their father except at locus DYS458. At this locus, while the eldest, second and fourth siblings share allele 18 with their father, a loss of one repeat (allele 17 instead of 18 is observed in the third son while fifth and sixth siblings have allele 19 representing a gain of one repeat. Thus, two changes viz. a gain (twice and loss of one repeat at this locus in one generation is both interesting and unusual.

  14. The Tongue and Quill

    Science.gov (United States)

    1997-06-30

    organization) (local address) Dear Brother (full name) Sincerely Mormon Bishop Mr. (full name) Church of Jesus Christ of Latter-day Saints (local...references to religious events. the Creation the Exodus the Crucifixion the Flood the Second Coming the Resurrection 42. Capitalize names of religious

  15. L’utilità della poesia: la lettera di Hölderlin al fratello Karl del I gennaio 1799. Una proposta di lettura

    Directory of Open Access Journals (Sweden)

    Elena Polledri

    2014-06-01

    Full Text Available After depicting the core function of correspondence for understanding Hölderlin, as well as contextualizing the letter to his brother Carl (January 1st 1799 in both his life and work, a close reading of this document focuses step by step on its political, philosophical and first and foremost poetological issues.

  16. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... and a Brother: Donna’s Story What are some strategies to prevent falls in PD patients? CareMAP: Mealtime ... Needs of the Caregiver Caregiver Summit 2016: Coping Strategy: Yoga & Stretching CareMAP: Putting Things in Place Expert ...

  17. The important semiotic indicators of Dostoyevsky's emotional image

    Directory of Open Access Journals (Sweden)

    Iskhakova Z.Z.

    2016-12-01

    Full Text Available This article is devoted to finding the emotional semiotic character of F. Dostoevsky that is expressed by the key characters' behaviour in 'The Gambler', 'Idiot', The Brothers Karamazov'. The object of the study is emotionally painted speeches of characters in his works. The subject of the study is emotive signs indices in emotional texts of Fyodor Dostoevsky.

  18. Disease: H01996 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available -diagnosed condition? ... JOURNAL ... Mol Cell Endocrinol 249:1-9 (2006) DOI:10.1016/j.mce.2006.02.003 ... PMID:158...fication of the first mutation in two brothers and restoration of activity by protein complementation. ... JOURNAL ... J Clin Endocrinol Metab 90:4101-7 (2005) DOI:10.1210/jc.2005-0123

  19. Tuberous Sclerosis in Identical Twins

    Directory of Open Access Journals (Sweden)

    Dinesh C Govil

    1987-01-01

    Full Text Available Tuberous sclerosis was, observed in six year old identical twin brothers born with single placenta and a single amnion. Both had adenoma sebaceum shagreen patches, ash leaf spots and progressive mental deterioration. One of them had a verrucous pigmented nevus on the, left temple and recurrent localized motor seizures.

  20. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Dignity & Identity CareMAP: Mealtime and Swallowing: Part 2 Walking for a Father and a Brother: Donna’s Story ... Caregivers from Caregivers What Are the Risks and Benefits of DBS Surgery? Ask the Helpline: Why Is ...

  1. Full closure strategic analysis.

    Science.gov (United States)

    2014-07-01

    The full closure strategic analysis was conducted to create a decision process whereby full roadway : closures for construction and maintenance activities can be evaluated and approved or denied by CDOT : Traffic personnel. The study reviewed current...

  2. The Full Inclusion Movement.

    Science.gov (United States)

    Machado, Rodney E.; And Others

    1996-01-01

    Overviews background of the movement toward full inclusion of special education students into regular classrooms, including legal issues and successful educational practices. Suggests that full inclusion does not benefit all students and that inclusion should be one of several alternatives to meeting students' educational needs. Of approximately…

  3. Full Service Leasing

    OpenAIRE

    Richter, Ján

    2009-01-01

    Aim of this master thesis is to describe the service of Full Service Leasing, as a modern form of financing and management of assets, primarily automobile fleet. Description of full service leasing is designed as a comprehensive and complete guide to support reader's position when deciding to finance and manage a fleet by this service. Whether the reader is an entrepreneur, CFO, fleet manager, new employee of leasing company, or anyone who is interested in this service, this master thesis wil...

  4. The Play Therapy Process of Sibling-Witnesses of Marital Violence

    Directory of Open Access Journals (Sweden)

    Miao-Jung Lin

    2014-06-01

    Full Text Available The purpose of this study is to explore play phases, play themes, and play behaviors in the play therapy processes of two siblings who were child witnesses of marital violence. Consensus qualitative research method was adopted to analyze the data. The results showed four phases in the siblings’ play therapies: the exploratory phase, the trauma phase, the transformation phase, and the ending phase. Within the four phases, same themes that were identified for both siblings were “exploration” in the exploratory phase, “destruction” in the trauma phase, and “blessing” in the ending phase. Differences in play themes were also identified to include “interaction”, “chaos”, “defensiveness”, “threatening” for the older brother during the trauma phase, while the younger of the two displayed “hostility”, “violence/aggression”, and “repetition”. In the transformation phase, the older brother displayed themes of “healing”, “nurturing/tending”, while the younger brother displayed themes of “protection”, “construction”, and “creation”. For the ending phase, the younger brother also displayed themes of “separation” and “wistfulness”. Some recommendations for practitioners and further research in play therapy are provided.

  5. Compressive full waveform lidar

    Science.gov (United States)

    Yang, Weiyi; Ke, Jun

    2017-05-01

    To avoid high bandwidth detector, fast speed A/D converter, and large size memory disk, a compressive full waveform LIDAR system, which uses a temporally modulated laser instead of a pulsed laser, is studied in this paper. Full waveform data from NEON (National Ecological Observatory Network) are used. Random binary patterns are used to modulate the source. To achieve 0.15 m ranging resolution, a 100 MSPS A/D converter is assumed to make measurements. SPIRAL algorithm with canonical basis is employed when Poisson noise is considered in the low illuminated condition.

  6. Full page insight

    DEFF Research Database (Denmark)

    Cortsen, Rikke Platz

    2014-01-01

    Alan Moore and his collaborating artists often manipulate time and space by drawing upon the formal elements of comics and making alternative constellations. This article looks at an element that is used frequently in comics of all kinds – the full page – and discusses how it helps shape spatio-t...

  7. Full page fax print

    Indian Academy of Sciences (India)

    user

    different classes, alkaloids, terpenes, oxygen heterocycles and other systems. It is impossible to do full justice to his work and this article provides only a selection ...... India is home to bounteous varieties of plants. However, very few of them have been studied, a vast majority being untouched. The scope for research in this ...

  8. Full Length Research Article

    African Journals Online (AJOL)

    Administrator

    Out of the 320 male sheep examined, 87(27.2%) were infected, while 9(19.1%) of the 47 females examined were infected (Table 2). Infection varied from one abattoir to another. Age related distribution of P. cervi is shown in Table 3. Out of 356 adult sheep (>2yrs) examined, 35. Full Length Research Article. 12 ...

  9. ISABELLE full scale dipoles

    International Nuclear Information System (INIS)

    McInturff, A.D.; Dahl, P.F.; Kassner, D.; Lasky, C.; Robins, K.; Sampson, W.B.

    1975-01-01

    Data are presented on the various cosine theta type magnet models constructed at BNL in the development of ring magnets for ISABELLE, a pair of intersecting 200 GeV proton accelerating storage rings. The rings are to be filled with 30 GeV protons from the AGS and then accelerated to 200 GeV. The acceleration period is a 120 sec ramp from approximately 0.5 T to 4 T. The effect of mechanical precompression on training was studied by varying the interference fit between the coil (ISA IV) and its iron shield. The results were used to optimize the mechanical design of the full-size magnet models

  10. Plate Full of Color

    Centers for Disease Control (CDC) Podcasts

    2008-08-04

    The Eagle Books are a series of four books that are brought to life by wise animal characters - Mr. Eagle, Miss Rabbit, and Coyote - who engage Rain That Dances and his young friends in the joy of physical activity, eating healthy foods, and learning from their elders about health and diabetes prevention. Plate Full of Color teaches the value of eating a variety of colorful and healthy foods.  Created: 8/4/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 8/5/2008.

  11. Coming Full Cycle.

    Science.gov (United States)

    Fay, Lindsey; Carll-White, Allison; Harrell, James

    2017-04-01

    This article illustrates a collaborative, full cycle diagnostic postoccupancy evaluation (POE) conducted in an emergency department (ED) to demonstrate methods of planning a POE, conducting research to capture meaningful data, and applying outcomes through the use of a design charrette. POEs often end with the reporting of findings rather than suggesting how this knowledge feeds forward. A design charrette presents an opportunity to engage with POE evidence and integrate research into practice. Planning for the POE resulted in a multiphased, multimethodological study. Data collection and analysis utilized objective and subjective measures yielding both qualitative and quantitative data. The design charrette then served as an interactive method to assist design practitioners in both understanding and applying the research findings in the redesign of the entry/triage sequence of the ED. POE findings revealed four key issues impacting the ED experience. These include workflow, communication, privacy and confidentiality, and safety and security. In analyzing the use of the charrette to link POE findings to design application, it was determined that the charrette should include an all-inclusive, collaborative process, easily interpreted evidence, active participant engagement, and feasible outcomes grounded in research. Taking the POE process full cycle is a critical component in bridging the gap between research and its application to design. The charrette process offers a positive mark of completion to the POE and helps participants gain sensitivity to the importance of evidence-based decision-making.

  12. Kreisbewegung Coming Full Circle

    Directory of Open Access Journals (Sweden)

    Karin Hartewig

    2000-11-01

    Full Text Available Männer und Frauen des deutschen Widerstands und eine Kulturwissenschaftlerin aus der zweiten Generation der Holocaust-Überlebenden sprechen in diesem Buch über das Verhalten der Widerstandskämpfer gegenüber ihren jüdischen Mitbürgern. Im Mittelpunkt der Gruppengespräche steht die Frage, warum die Regime-Gegner die Verfolgung und Vernichtung der Juden in ihrem oppositionellen Handeln ausgeblendet haben.In this book, men and women of the German Resistance talk to a female scholar of cultural studies, belonging to the second generation of Holocaust survivors, about the members of the Resistance’s attitude towards their Jewish fellow citizens. Their group conversations mainly deal with the question why the opponents of the regime marginalized the problem of the prosecution and extermination of the Jews in their oppositional activities.

  13. Full metal jacket!

    CERN Multimedia

    Laëtitia Pedroso

    2011-01-01

    Ten years ago, standard issue clothing only gave CERN firemen partial protection but today our fire-fighters are equipped with state-of-the-art, full personal protective equipment.   CERN's Fire Brigade team. For many years, the members of CERN's Fire Brigade went on call-outs clad in their work trousers and fire-rescue coats, which only afforded them partial protection. Today, textile manufacturing techniques have moved on a long way and CERN's firemen are now kitted out with state-of-the-art personal protective equipment. The coat and trousers are three-layered, comprising fire-resistant aramide, a protective membrane and a thermal lining. The CERN Fire Brigade' new state-of-the-art personal protection equipment. "This equipment is fully compliant with the standards in force and is therefore resistant to cuts, abrasion, electrical arcs with thermal effects and, of course, fire," explains Patrick Berlinghi, the CERN Fire Brigade's Logistics Officer. You might think that su...

  14. Pop / Tõnis Kahu

    Index Scriptorium Estoniae

    Kahu, Tõnis, 1962-

    2008-01-01

    Heliplaatidest: Chemical Brothers "Brotherhood", Plutonium 74 "Peittoalueen ulkopuolella", Disturbed "Indestructible", Thomas Feiner & Anywhen "The Opiates Revised", DefRage "Save Us from Religion", Kago "Mopskassi maja"

  15. Ausambad Newfoundlandi eestisoost seenesõpradele / foto: Helen Spencer

    Index Scriptorium Estoniae

    2008-01-01

    Newfoundlandis asuva Brother Brennan Environmental Education Centre (BBEEC) poolt korraldadavatest seenekursustest, mille õppejõuks kutsuti Newfoundlandis seenehuvilistena tuntud Maria ja Andrus Voitk

  16. Is the association between general cognitive ability and violent crime caused by family-level confounders?

    Directory of Open Access Journals (Sweden)

    Thomas Frisell

    Full Text Available BACKGROUND: Research has consistently found lower cognitive ability to be related to increased risk for violent and other antisocial behaviour. Since this association has remained when adjusting for childhood socioeconomic position, ethnicity, and parental characteristics, it is often assumed to be causal, potentially mediated through school adjustment problems and conduct disorder. Socioeconomic differences are notoriously difficult to quantify, however, and it is possible that the association between intelligence and delinquency suffer substantial residual confounding. METHODS: We linked longitudinal Swedish total population registers to study the association of general cognitive ability (intelligence at age 18 (the Conscript Register, 1980-1993 with the incidence proportion of violent criminal convictions (the Crime Register, 1973-2009, among all men born in Sweden 1961-1975 (N = 700,514. Using probit regression, we controlled for measured childhood socioeconomic variables, and further employed sibling comparisons (family pedigree data from the Multi-Generation Register to adjust for shared familial characteristics. RESULTS: Cognitive ability in early adulthood was inversely associated to having been convicted of a violent crime (β = -0.19, 95% CI: -0.19; -0.18, the association remained when adjusting for childhood socioeconomic factors (β = -0.18, 95% CI: -0.18; -0.17. The association was somewhat lower within half-brothers raised apart (β = -0.16, 95% CI: -0.18; -0.14, within half-brothers raised together (β = -0.13, 95% CI: (-0.15; -0.11, and lower still in full-brother pairs (β = -0.10, 95% CI: -0.11; -0.09. The attenuation among half-brothers raised together and full brothers was too strong to be attributed solely to attenuation from measurement error. DISCUSSION: Our results suggest that the association between general cognitive ability and violent criminality is confounded partly by factors shared by

  17. Appraisal of Marist Education in the Light of Patristic Education

    Science.gov (United States)

    Osuji, Gregory Ekene; Oluoch-Suleh, Everlyn

    2015-01-01

    The Study evaluated the Marist Brother Lecturer and the Marist Student in Marist International University College, Karen, Nairobi in the light of the Education founded on Christian principles by Jesus Christ and expounded by the early Church Fathers. The Researchers tried to find out the attitude of both Marist Brother Lecturer and Marist Student…

  18. 20 CFR 404.2040 - Use of benefit payments.

    Science.gov (United States)

    2010-04-01

    ....2040 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY... beneficiary's brother, who is the payee, learns the beneficiary needs new shoes and does not have any funds to purchase miscellaneous items at the institution's canteen. The payee takes his brother to town and buys him...

  19. 38 CFR 1.10 - Eligibility for and disposition of the United States flag for burial purposes.

    Science.gov (United States)

    2010-07-01

    ... dishonorable, after serving at least one enlistment, or for a disability incurred or aggravated in line of duty... Selected Reserve, for a disability incurred or aggravated in the line of duty; or (C) Died while a member... foster parents. (iv) Brothers or sisters, including brothers or sisters of the halfblood. (v) Uncles or...

  20. 20 CFR 725.201 - Who is entitled to benefits; contents of this subpart.

    Science.gov (United States)

    2010-04-01

    ... surviving spouse or child, or the surviving dependent brothers or sisters, where there is no surviving... part the term “total disability” shall mean partial disability with respect to a claim for which... entitlement to benefits applicable to a miner, or a surviving spouse, child, parent, brother, or sister, and...

  1. 20 CFR 410.515 - Modification of benefit amounts; general.

    Science.gov (United States)

    2010-04-01

    ..., parent, brother, or sister, the excess earnings from wages and from net earnings from self-employment (see § 410.530) of such miner, parent, brother, or sister, respectively; or (2) Failure to report...); or (3) The receipt by a beneficiary of payments made because of the disability of the miner due to...

  2. 20 CFR 725.533 - Modification of benefits amounts; general.

    Science.gov (United States)

    2010-04-01

    ... partial or total disability due to pneumoconiosis; or (3) In the case of benefits to a parent, brother, or... because of death or partial or total disability due to pneumoconiosis; or (2) Any compensation or benefits... (see § 410.530 of this title) of such parent, brother, sister, or miner, respectively; or (4) The fact...

  3. 20 CFR 410.510 - Computation of benefits.

    Science.gov (United States)

    2010-04-01

    ... surviving child of a miner or widow, or a parent, brother, or sister of a miner, is entitled to benefits for..., brother, or sister of a miner, who establishes entitlement to benefits under the provisions of subpart B... benefits) based on the disability or death due to pneumoconiosis arising out of the coal mine employment of...

  4. 20 CFR 725.520 - Computation of benefits.

    Science.gov (United States)

    2010-04-01

    ... parent, brother, or sister of a miner, is entitled to benefits for a month for which he or she is the... surviving child of a miner or surviving spouse, or a surviving parent, brother, or sister of a miner, who... dependent for purposes of augmentation of benefits) based on the disability or death due to pneumoconiosis...

  5. 20 CFR 410.610 - Administrative actions that are initial determinations.

    Science.gov (United States)

    2010-04-01

    ... HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Determinations of Disability, Other... § 410.511(a)). (n) Support of parent, brother, or sister. The Administration shall make findings..., brother, or sister, meets the requirements for support from the miner set forth in the pertinent...

  6. 10 CFR 1060.501 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Uniformed Service. (e) Handicapped individual means a person who has a physical or mental disability or..., by blood, marriage, or operation of law, as father, mother, son, daughter, brother, sister, uncle..., father-in-law, mother-in-law, son-in-law, daughter-in-law, brother-in-law, sister-in-law, stepfather...

  7. Maailma börsid uues pöörises / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2008-01-01

    USA-st alanud finantskriis kogub uut hoogu. Investeerimispanga Lehman Brothers päästmine ebaõnnestus ning pank palus kohtult pankrotikaitset. Endine USA keskpanga juht Alan Greenspan ennustab veel mitme suur finantsasutuse pankrotti. Vt. samas: Lehman Brothers; Miks aktsiaturud langevad? Diagramm: USA finantskriisi järgmised ohvrid; Virge Lahe. USA finantskriis kergitab laenu hinda ka Eesti pankades

  8. In de ban van het incestverbod : analyse van een historische omslag in de verbeelding van erotiek tussen broer en zuster

    NARCIS (Netherlands)

    Coebergh-van der Marck, Marie-Anne

    2012-01-01

    Central in the representation of eroticism between brother and sister, classical theme in litterature and film, stands the incest prohibition as source of tension between similarity and difference. Brother and sister share the same genes and because of this they belong together and go different

  9. Group Psychotherapy with Long-Term Inpatients: Application of a Model.

    Science.gov (United States)

    Griffin-Shelley, Eric; Wendel, Sandra

    1988-01-01

    Describes group psychotherapy at an inpatient, psychiatric hospital serving priests, nuns, and religious brothers. Discusses formation of and differences among four groups: a low-level group for sisters; an interactional group for sisters; a high-level, Gestalt-oriented group for sisters; and an interactional group for priests and brothers. (ABL)

  10. Genesis 37: 25 29 And Its Offered Challenges In The 21st Century ...

    African Journals Online (AJOL)

    The paper will be looking at issues from the biblical perspective as it relates to trafficking given the setting in Genesis 37 where Joseph was sold by his brothers into slavery. The preceding experience was the first recorded instance of one being sent into slavery not as a result of war scenario but because his brothers ...

  11. Gideon Fagan's studies at the Royal College of Music in London ...

    African Journals Online (AJOL)

    The South African composer Gideon Fagan (1904-1980) studied at the Royal College of Music (RCM) in London between 1922 and 1926. Fagan followed in the footsteps of his elder brother Johannes (1898-1920) who had committed suicide in 1920 while a student at the RCM. Considering his brother's tragic death, ...

  12. How Two Bicycle Mechanics Achieved the World's First Powered Flight

    Indian Academy of Sciences (India)

    Indeed the striking thing about their aviation project was how extraordinarily systematic, analytical and ingenious they were. Although neither of the two brothers had even passed high school, they were both well educated in the true sense of the word. In particular the elder brother Wilbur was very well read, and had to drop ...

  13. That's Not Montessori

    Science.gov (United States)

    Peters, Dane L.

    2009-01-01

    The author could not contain herself one day at school recently when a parent of three children shared something she had heard from her eldest daughter. That morning, the eldest daughter was grumbling about the fact that she and her Lower Elementary brother had to go to school while her Preschool brother did not, and she announced to her mother,…

  14. "We Are Not Terrorists," but More Likely Transnationals: Reframing Understandings about Immigrants in Light of the Boston Marathon Bombings

    Science.gov (United States)

    Kasun, G. Sue

    2013-01-01

    The Boston Marathon bombings in April 2013 created a new kind of discomfort in the United States about "self-radicalized" terrorists, particularly related to Muslim immigrants. The two suspected bombers, brothers with Chechen backgrounds, had attended U.S. public schools. News media portrayed the brothers as "immigrants" and…

  15. 24 CFR 257.7 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... following— (1) The person's father, mother, stepfather, stepmother, brother, sister, stepbrother, stepsister, son, daughter, stepson, stepdaughter, grandparent, grandson, granddaughter, father-in-law, mother-in-law, brother-in-law, sister-in-law, son-in-law, daughter-in-law, the spouse of any of the foregoing...

  16. 50 CFR 622.18 - South Atlantic snapper-grouper limited access.

    Science.gov (United States)

    2010-10-01

    ...: husband, wife, son, daughter, brother, sister, mother, or father; or (B) From an individual to a...: husband, wife, son, daughter, brother, sister, mother, or father. The application for transfer of a permit... permit will not be renewed if the annual report shows a new shareholder other than a husband, wife, son...

  17. 12 CFR 225.41 - Transactions requiring prior notice.

    Science.gov (United States)

    2010-01-01

    ... father, mother, stepfather, stepmother, brother, sister, stepbrother, stepsister, son, daughter, stepson, stepdaughter, grandparent, grandson, granddaughter, father-in-law, mother-in-law, brother-in-law, sister-in-law, son-in-law, daughter-in-law, the spouse of any of the foregoing, and the person's spouse. (c...

  18. Asperger's in the Holmes Family

    Science.gov (United States)

    Altschuler, Eric L.

    2013-01-01

    I show that Mycroft Holmes (Sherlock Holmes' brother) is a formally described case of Asperger's syndrome a half century before Asperger's description of the syndrome. Further, given the genetic similarity and links between the brothers stated by Sherlock, this also cinches the same diagnosis for Sherlock.

  19. Public health and the food and drinks industry: The governance and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Brother is a pricing analyst for Dunnhumby, a subsidiary of the UK retailer Tesco. Brother's work does not influence my ... control strategy in Mexico: actors, actions and conflicts of interest. Simón Barquera, Karina ..... CASE 7 describes how a front-of-pack nutrition labelling strategy was developed in Mexico as part of the ...

  20. A dream come true

    Indian Academy of Sciences (India)

    Lawrence

    Iwas born into a middle class family in Bangalore. I have an elder brother, two elder sisters and an younger sister. We had our grand parents living with us. My father, the eldest in his family, had the responsibility of educating all his brothers and sis- ters and getting them married! We always had a lot of people at home and I ...

  1. Reframing Paul's sibling language in light of Jewish epistolary forms ...

    African Journals Online (AJOL)

    2015-06-17

    Jun 17, 2015 ... to read online. Introduction. Scholars have predominantly focused on the usage of 'brothers' or 'brother' in light of the Greco-. Roman epistolary conventions and cultural milieus.1 They conclude that, through sibling language,. Paul intends to enrich group solidarity, to emphasise the emotional attachment ...

  2. Rome.The Etymological Origins

    Directory of Open Access Journals (Sweden)

    Enrique Cabrejas

    2016-02-01

    Full Text Available The name of Rome was always a great mystery. Through this taxonomic study of Greek and Latin language, Enrique Cabrejas gives us the keys and unpublished answers to understand the etymology of the name. For thousands of years never came to suspect, including about the founder Romulus the reasons for the name and of his brother Remus, plus the unknown place name of the Lazio of the Italian peninsula which housed the foundation of ancient Rome.

  3. The betrayal of Edom: Remarks on a claimed tradition

    Directory of Open Access Journals (Sweden)

    Bob Becking

    2016-09-01

    Full Text Available Biblical and post-Biblical texts refer to the tradition of the betrayal of Edom. During theconquest the brother-nation of Edom would have betrayed Judah by choosing sides with the Babylonians. Historical and archaeological evidence for this ‘fact’ is absent or not convincing. It is argued that the occupation of Southern Judah by the Edomites in late Babylonian and/or Persian times would have been the source of this claimed tradition.

  4. Traian Vuia – the Romanian inventor who first flew a powered airplane in 1906

    Directory of Open Access Journals (Sweden)

    Liviu FILIMON

    2011-09-01

    Full Text Available As observed the beginning of heavier than air devices started with Wright Brothers who flew in 1903 the first catapulted airplane equipped with an engine, similar to present motor gliders. In March 1906 took place the first flight of Vuia’s monoplane using on board installations. Since then a real competition between manufacturers has started to improve their airplanes as they become more efficient. Traian Vuia’s first flights and his beginnings are explained below.

  5. Post-scurfy sciatic neuralgia: case report

    Directory of Open Access Journals (Sweden)

    Evaristo Febles Piñar

    2012-05-01

    Full Text Available Introduction: Post scurfy neuralgia is a frequent cause of chronic intractable pain and constitutes the most feared complication of Herpetic Neuralgia. It can last for many years leading the patient to despair, depression, social isolation, and suicidal ideas. Ojectives: To present the clinical course of an elderly patient with post herpetic sciatic neuralgia treated at the Pain Clinic of Ameijeiras Brothers Hospital in January of 2011. Conclusions: Success in treating post scurfy neuralgia is related to early detection and intervention.

  6. Contribution to the Catalogue of the painter and illustrator John Vanderbank: Six new Oils with Scenes of The Quixote in the Museum of Pontevedra

    Directory of Open Access Journals (Sweden)

    María Ángeles Tilve Jar

    2014-12-01

    Full Text Available In the Museum of Pontevedra stands out a set of six pictures of small format that narrate scenes of the Quixote. Realized in oil on table, they are works of the Englishman painter and illustrator John Vanderbank (1694-1739. In those pictures he adapts some of the prints that himself designed to illustrate the edition of luxury of Miguel de Cervantes who, promoted by Lord Carteret and printed by the Tonson brothers, was realized in London in 1738.

  7. AHP 47: YELLOW-HEAD HORSE

    Directory of Open Access Journals (Sweden)

    Sangs rgyas bkra shis སངས་རྒྱས་བཀྲ་ཤིས།

    2017-04-01

    Full Text Available My family had a stallion we called Rta mgo ser 'Yellow-Head Horse'. Father and two of his brothers occasionally rode it. Father said that Yellow-Head was very wild when it was taken to join local horseraces. I didn't believe that because Yellow-Head was very gentle when Mother rode it to the local monastery and also when I rode it.

  8. Introduction

    Directory of Open Access Journals (Sweden)

    Alfred Hornung

    2012-01-01

    Full Text Available Forty years after the assassination of Dr. Martin Luther King, Jr., the charismatic leader of the civil rights movement, Barack H. Obama was elected the first African American president of the United States of America in 2008. Although U.S. Attorney General Robert Kennedy had predicted in 1961 that a black person could be president like his brother “in the next thirty or forty years,” nobody really expected this kind of victory to come true.

  9. How Full is Full Employment? : How Tools and Not Theory Explained Full Employment

    NARCIS (Netherlands)

    Rodenburg, P.

    2016-01-01

    The post-war debate on full employment policy was blurred and unclear since the concept of full employment itself was theoretically unclear and un-operational. Unable to theoretically determine the unemployment level of full employment, economists tried to find more empirically based ways to

  10. Logical Full Abstraction and PCF

    OpenAIRE

    Longley, John R; Plotkin, Gordon

    2000-01-01

    We introduce the concept of logical full abstraction, generalising the usual equational notion. We consider the language PCF and two extensions with “parallel” operations. The main result is that, for standard interpretations, logical full abstraction is equivalent to equational full abstraction together with universality; the proof involves constructing enumeration operators. We also consider restrictions on logical complexity and on the level of types.

  11. Review of Two Siblings with Werner's Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Murat Sert

    2009-01-01

    Full Text Available We report the clinical course of two siblings with Werner's syndrome (WS who were diagnosed and followed at our clinics for 12 years. Initial diagnosis of the first sibling (sister was at age 20, the second (brother at 16. At the initial diagnosis, the sister had amenorrhea, muscle atrophy at arms and legs, diabetes mellitus (DM, short stature, bilateral cataracts, genital hypoplasia, osteoporosis, and gray hair. During 12 years follow-up period, high-pitched voice, hepatosteatosis, renal parenchymal disease, and urethral obstruction developed. Regarding the brother, DM, cataracts and genital hypoplasia were observed at the initial diagnosis. During the 12 years follow-up period, gray hair, high-pitched voice, steatohepatosis, and osteoporosis developed.

  12. Financial Contagion in the Recent Financial Crisis: Evidence from the Romanian Capital Market

    Directory of Open Access Journals (Sweden)

    Cărăușu Dumitru-Nicușor

    2017-01-01

    Full Text Available We use the wavelet analysis in order to investigate if financial contagion occurred between the US and the Romanian capital market in the beginning of the recent economic crisis. Moreover, we test presence of pure and fundamental contagion between the two markets using wavelet coherency analysis and maximal overlap discrete wavelet transform methodology. We find evidence of pure financial contagion between the two markets: during the sub-primes crisis period, the Lehman Brothers collapse and at the beginning of sovereign debt crisis. Furthermore, we find a general short-term increase in interdependence between the two markets in the ex-ante and ex-post Lehman brothers period. Meanwhile, the capital market from Romania and US were in perfect sync during 2007-2009 for high trading time-windows. This implies that the Romanian market was sensitive to short-term shock from the US market, which lead to a long-term fundamental contagion.

  13. AHP 44: DPAL RGYAL: ARTIST AND PHOTOGRAPHER

    Directory of Open Access Journals (Sweden)

    Klu thar rgyal ཀླུ་ཐར་རྒྱལ།

    2017-02-01

    Full Text Available One sweltering summer afternoon in 2016, my family was enjoying yogurt while sitting in order of age around a table at my home. Father suddenly clapped his leg and blurted out "Oh! I remember!" took his cell phone from his coat pocket and said, "Klu kho, please translate these new Chinese messages for me." "China Mobile is really your best friend! It texts you almost every day!" I joked, taking the phone from his hand. One message was for my older brother, Dpal rgyal. The prefecture government informed Brother (b. 1980 that he was chosen to represent Mtsho lho (Hainan Tibetan Autonomous Prefecture for the 2016 Mtsho sngon (Qinghai Province Disabled Persons vocational skills competition in the photography category. Photography contestants were required to bring their own camera and would take photographs at the competition venue. ...

  14. Ataxia with Vitamin E Deficiency May Present with Cervical Dystonia

    Directory of Open Access Journals (Sweden)

    Andrew E. Becker

    2016-05-01

    Full Text Available Background: Ataxia with vitamin E deficiency (AVED is an autosomal recessive disorder that usually presents with ataxia, areflexia, and proprioceptive and vibratory sensory loss. Dystonia has been reported rarely. Case Report: An 11‐year‐old female presented with dystonic head tremor and cervical and bilateral arm dystonia. Her 14‐year‐old older brother had dystonic head tremor and generalized dystonia. One year later, the brother developed dysarthria, limb dysmetria, and gait ataxia. Compound heterozygous mutations in TTPA were detected, confirming the diagnosis of AVED. Discussion: AVED may present with dystonia rather than ataxia, and should be considered in the differential diagnosis of progressive dystonia. 

  15. The innate immune response status correlates with a divergent clinical course in congenital Chagas disease of twins born in a non-endemic country.

    Science.gov (United States)

    Fernández-Villegas, Ana; Thomas, M Carmen; Carrilero, Bartolomé; Téllez, Cinta; Marañón, Concepción; Murcia, Laura; Moralo, Sara; Alonso, Carlos; Segovia, Manuel; López, Manuel Carlos

    2014-12-01

    The innate immune response from diamniotic and dichorionic twin brothers congenitally infected with Trypanosoma. cruzi (strain DTU-V) who displayed different clinical symptomatology was studied. While Brother I manifested severe cardiac and digestive disorders, the Brother II showed slight splenomegaly. The secretion level of IL-1β, TNF-α, IL-12, IL-10, IFN-α and IL-6 cytokines produced after stimulation of peripheral blood cells with TLR-2, TLR-4 and TLR-9 ligands was determined pre- and post-benznidazole treatment. Cells from 10 uninfected infants born to mothers seropositive for Chagas disease were included as control. The obtained data show that the cells of Brother I secreted lower levels of the pro-inflammatory cytokines IL-1β and TNF-α (upon TLR-2 and TLR-4 stimulation) relative to those secreted by cells from Brother II and uninfected controls. The cells from Brother II secreted high levels of the IL-1β cytokine following TLR-2 stimulation relative to uninfected controls. The cells from both brothers secreted a higher level of IL-6, following TLR-4 stimulation, than that secreted by uninfected infant cells. After treatments, the cytokine secretion levels were similar in both children and comparable to those of uninfected donors. Treatment success in Brother I and treatment interruption in Brother II was detected by the use of serological biomarkers (KMP11, HSP70, PFR2, Tgp63) as well as follow-up done by PCR. Therefore, the Brother II required a second treatment. The data presented suggest that benznidazol treatment allows the innate immune system to reach a fully functional status similar to that of uninfected subjects. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Principle extremum of full action

    Directory of Open Access Journals (Sweden)

    Solomon I. Khmelnik

    2011-10-01

    Full Text Available A new variational principle extremum of full action is proposed, which extends the Lagrange formalism on dissipative systems. It is shown that this principle is applicable in electrical engineering, electrodynamics, mechanics and hydrodynamics, taking into account the friction forces. The proposed variational principle may be considered as a new formalism used as an universal method of physical equations derivation, and also as a method for solving these equations.

  17. Rectilinear Full Steiner Tree Generation

    DEFF Research Database (Denmark)

    Zachariasen, Martin

    1999-01-01

    The fastest exact algorithm (in practice) for the rectilinear Steiner tree problem in the plane uses a two-phase scheme: First, a small but sufficient set of full Steiner trees (FSTs) is generated and then a Steiner minimum tree is constructed from this set by using simple backtrack search, dynamic...

  18. [Endoscopic full-thickness resection].

    Science.gov (United States)

    Meier, B; Schmidt, A; Caca, K

    2016-08-01

    Conventional endoscopic resection techniques such as endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) are powerful tools for the treatment of gastrointestinal (GI) neoplasms. However, those techniques are limited to the superficial layers of the GI wall (mucosa and submucosa). Lesions without lifting sign (usually arising from deeper layers) or lesions in difficult anatomic positions (appendix, diverticulum) are difficult - if not impossible - to resect using conventional techniques, due to the increased risk of complications. For larger lesions (>2 cm), ESD appears to be superior to the conventional techniques because of the en bloc resection, but the procedure is technically challenging, time consuming, and associated with complications even in experienced hands. Since the development of the over-the-scope clips (OTSC), complications like bleeding or perforation can be endoscopically better managed. In recent years, different endoscopic full-thickness resection techniques came to the focus of interventional endoscopy. Since September 2014, the full-thickness resection device (FTRD) has the CE marking in Europe for full-thickness resection in the lower GI tract. Technically the device is based on the OTSC system and combines OTSC application and snare polypectomy in one step. This study shows all full-thickness resection techniques currently available, but clearly focuses on the experience with the FTRD in the lower GI tract.

  19. The Boston Marathon Bombers: the Lethal Cocktail that Turned Troubled Youth to Terrorism

    Directory of Open Access Journals (Sweden)

    Anne Speckhard

    2013-06-01

    Full Text Available The Tsarnaev brothers came from the war-torn Chechen diaspora and found asylum in the United States. The elder brother,Tamerlan, carried actual memories of fleeing from the 1994-96 Chechen war. He also lived in Dagestan for a year at the time when the Chechen warlord Basayev was engaging in a campaign of more than thirty suicide attacks, including mass hostage takings. When Tamerlan made it to the United States, he tried to assimilate but failed to make it. The family struggled hard to make a living in the U.S.; but in the end the parents divorced and the father returned to Dagestan. Dzhokhar, the younger brother, made it into an American university but Tamerlan did not succeed in higher education, trying to pursue a boxing career instead. When his immigration status precluded a boxing career, he became disillusioned. Meanwhile his mother, concerned about his descent into smoking marijuana and drinking alcohol, arranged an Islamic tutor for him. The ingredients for the lethal cocktail of terrorism came together when Tamerlan's individual vulnerabilities made him seek online contacts via the Internet and brought him in touch with offline mentors, militants and extremists who glorified Al-Qaeda’s global jihad. Through these channels he became receptive to the terrorist ideology, found a jihadist group with global reach to align with, received technical instructions from the Inspire magazine and found enough support for executing the Boston marathon attack, pulling his younger brother along and dying in the process as he had expected.

  20. Full-F gyrofluid model

    DEFF Research Database (Denmark)

    Madsen, Jens

    2013-01-01

    A global electromagnetic gyrofluid model based on the full-F gyrokinetic model is derived. The gyrofluid moment variables are not split into fluctuating and equilibrium parts. Profiles are evolved freely, and gyro-averaging operators are not parametrized, but are functions of the gyrofluid moment...... variables. The fluid moment hierarchy is closed by approximating the gyrokinetic distribution function as a finite order Hermite-Laguerre polynomial and by determining closure approximations for terms involving the gyrokinetic gyro-averaging operator. The model exactly conserves the gyrokinetic full......-F energy invariant evaluated using the Hermite-Laguerre decomposition. The model is suited for qualitative studies of the interplay between turbulence, flows, and dynamically evolving profiles in magnetically confined plasmas....

  1. FULL WAVEFORM ACTIVE HYPERSPECTRAL LIDAR

    OpenAIRE

    T. Hakala; J. Suomalainen; S. Kaasalainen

    2012-01-01

    We have developed a prototype full waveform hyperspectral LiDAR and investigated its potential for remote sensing applications. Traditionally hyperspectral remote sensing is based on passive measurement of sunlit targets. These methods are sensitive to errors in illumination conditions and lack the range information. Our prototype can measure both the range and the spectral information from a single laser pulse. At this stage, the instrument is optimized for short range terrestrial a...

  2. Workflows for Full Waveform Inversions

    Science.gov (United States)

    Boehm, Christian; Krischer, Lion; Afanasiev, Michael; van Driel, Martin; May, Dave A.; Rietmann, Max; Fichtner, Andreas

    2017-04-01

    Despite many theoretical advances and the increasing availability of high-performance computing clusters, full seismic waveform inversions still face considerable challenges regarding data and workflow management. While the community has access to solvers which can harness modern heterogeneous computing architectures, the computational bottleneck has fallen to these often manpower-bounded issues that need to be overcome to facilitate further progress. Modern inversions involve huge amounts of data and require a tight integration between numerical PDE solvers, data acquisition and processing systems, nonlinear optimization libraries, and job orchestration frameworks. To this end we created a set of libraries and applications revolving around Salvus (http://salvus.io), a novel software package designed to solve large-scale full waveform inverse problems. This presentation focuses on solving passive source seismic full waveform inversions from local to global scales with Salvus. We discuss (i) design choices for the aforementioned components required for full waveform modeling and inversion, (ii) their implementation in the Salvus framework, and (iii) how it is all tied together by a usable workflow system. We combine state-of-the-art algorithms ranging from high-order finite-element solutions of the wave equation to quasi-Newton optimization algorithms using trust-region methods that can handle inexact derivatives. All is steered by an automated interactive graph-based workflow framework capable of orchestrating all necessary pieces. This naturally facilitates the creation of new Earth models and hopefully sparks new scientific insights. Additionally, and even more importantly, it enhances reproducibility and reliability of the final results.

  3. LHCb : Full Experiment System Test

    CERN Multimedia

    Cattaneo, M

    2009-01-01

    LHCb had been planning to commission its High Level Trigger software and Data Quality monitoring procedures using real collisions data from the LHC pilot run. Following the LHC incident on 19th September 2008, it was decided to commission the system using simulated data. This “Full Experiment System Test” consists of: - Injection of simulated minimum bias events into the full HLT farm, after selection by a simulated Level 0 trigger. - Processing in the HLT farm to achieve the output rate expected for nominal LHC luminosity running, sustained over the typical duration of an LHC fill. - Real time Data Quality validation of the HLT output, validation of calibration and alignment parameters for use in the reconstruction. - Transmission of the event data, calibration data and book-keeping information to Tier1 sites and full reconstruction of the event data. - Data Quality validation of the reconstruction output. We will report on the preparations and results of FEST09, and on the status of commissioning for no...

  4. A study about siblings in the face of intellectual disability

    Directory of Open Access Journals (Sweden)

    Olga Lizasoain

    2010-05-01

    Full Text Available Research has shown that siblings of a person with intellectual disabilities can present problems of identification and socialization, the need for compensation, early adoption of large responsibilities, feelings of abandonment, guilt, shame or sadness. Nevertheless, if the needs of these brothers and sisters are facing, disability can become a source of personal and family enrichment. This article presents the initial conclusions drawn after a series of personal interviews conducted with siblings of students in a special education school. Awareness of the issue leads us to approach this study with the aim of providing guidelines of intervention to help siblings to minimize the potential negative impact of having a brother or sister with intellectual disabilities, and facilitate the development of attitudes and behaviours that enable them to face stressful situations in a constructive manner. Thanks to the direct experience of those who have been confronted with this situation, is issued to prevent psychosocial problems associated with having a brother or sister with these features.

  5. Cine club

    CERN Multimedia

    Cine club

    2017-01-01

    Wednesday 21 June 2017 at 20:00 CERN Council Chamber Soul Kitchen Directed by Fatih Akin Germany / France / Italy, 2009, 99 minutes In Hamburg, Zinos has a restaurant serving poor-man's fare; he gets by, but his girlfriend has taken a job in Shanghai, he's hurt his back and can't cook, his feckless brother can be on daily parole from jail only if Zinos employs him (though his brother doesn't want to work), a school acquaintance wants to buy the restaurant property, and the tax authority and health inspector are on his case. Zinos hires a temperamental chef and loses all his customers, signs a power of attorney giving his brother full authority at the restaurant, and buys a ticket to Shanghai. Is this a recipe for disaster? Original version German / Greek / Spanish / Turkish / English; English subtitles Wednesday 28 June 2017 at 20:00 CERN Council Chamber In July (Im Juli) Directed by Fatih Akin Germany, 2000, 99 minutes Daniel is a young teacher who, in contrast to ever...

  6. Electoral system and electoral campaign in Ancient Rome

    Directory of Open Access Journals (Sweden)

    Notari Tamaš

    2011-01-01

    Full Text Available One of the most famous orators of the Antiquity, Marcus Tullius Cicero entered the election for the consul's position held in 64 B.C. arranged under extremely disturbed circumstances and he won the consulatus for 63 B.C. Difficulties were caused among others by the fact that an indebted nobleman called Lucius Sergius Catilina saw the only breakthrough for ensuring his political and financial survival in being elected consul, and manifested that in case he would lose he would be willing to take as well violent actions (later, he actually carried out his threats. The orator's younger brother, Quintus Tullius Cicero wanted to help his brother in his campaign foreseen as having quite a lot of turns; so, he wrote a manual for him on the lawful and illegal instruments that could be used in the elections. This work, Commentariolum petitionis (A Handbook for Applicants for Offices is the first summary of campaign strategy in the history of mankind. In addition to the evaluation of the given situation, the presentation (and exploitation of the weaknesses of counter nominees, the book provides advice on several counts that might possibly continue to have relevance even today. We do not know to what extent the experienced politician, Cicero adhered to his younger brother's advice; it is, however, a fact that he was elected consul, and as a consul he defeated Catilina's revolt in. 63 B.C.

  7. Achieving and sustaining full employment.

    Science.gov (United States)

    Rosen, S M

    1995-01-01

    Human rights and public health considerations provide strong support for policies that maximize employment. Ample historical and conceptual evidence supports the feasibility of full employment policies. New factors affecting the labor force, the rate of technological change, and the globalization of economic activity require appropriate policies--international as well as national--but do not invalidate the ability of modern states to apply the measures needed. Among these the most important include: (I) systematic reduction in working time with no loss of income, (2) active labor market policies, (3) use of fiscal and monetary measures to sustain the needed level of aggregate demand, (4) restoration of equal bargaining power between labor and capital, (5) social investment in neglected and outmoded infrastructure, (6) accountability of corporations for decisions to shift or reduce capital investment, (7) major reductions in military spending, to be replaced by socially needed and economically productive expenditures, (8) direct public sector job creation, (9) reform of monetary policy to restore emphasis on minimizing unemployment and promoting full employment. None are without precedent in modern economies. The obstacles are ideological and political. To overcome them will require intellectual clarity and effective advocacy.

  8. FULL WAVEFORM ACTIVE HYPERSPECTRAL LIDAR

    Directory of Open Access Journals (Sweden)

    T. Hakala

    2012-08-01

    Full Text Available We have developed a prototype full waveform hyperspectral LiDAR and investigated its potential for remote sensing applications. Traditionally hyperspectral remote sensing is based on passive measurement of sunlit targets. These methods are sensitive to errors in illumination conditions and lack the range information. Our prototype can measure both the range and the spectral information from a single laser pulse. At this stage, the instrument is optimized for short range terrestrial applications. An active hyperspectral LiDAR opens up new possibilities for LiDAR data analysis. The lack of spectral information in traditional monochrome LiDARs rules out many of the classification techniques available for processing of hyperspectral data. Similarly, passive hyperspectral data does not allow extensive use of the classifications based on 3D shape parameters. With both hyperspectral and range data available in a single dataset, the best of the techniques can be applied to form more reliable classification results. The data also allows the mapping of spectral indices in 3D. As an example a Norway spruce is measured and spatial distribution of several spectral indices is illustrated.

  9. Review Document: Full Software Trigger

    CERN Document Server

    Albrecht, J; Raven, G

    2014-01-01

    This document presents a trigger system for the upgraded LHCb detector, scheduled to begin operation in 2020. This document serves as input for the internal review towards the "DAQ, online and trigger TDR". The proposed trigger system is implemented entirely in software. In this document we show that track reconstruction of a similar quality to that available in the offline algorithms can be performed on the full inelastic $pp$-collision rate, without prior event selections implemented in custom hardware and without relying upon a partial event reconstruction. A track nding eciency of 98.8 % relative to oine can be achieved for tracks with $p_T >$ 500 MeV/$c$. The CPU time required for this reconstruction is about 40 % of the available budget. Proof-of-principle selections are presented which demonstrate that excellent performance is achievable using an inclusive beauty trigger, in addition to exclusive beauty and charm triggers. Finally, it is shown that exclusive beauty and charm selections that do not intr...

  10. Full MOX core for PWRs

    International Nuclear Information System (INIS)

    Puill, A.; Aniel-Buchheit, S.

    1997-01-01

    Plutonium management is a major problem of the back end of the fuel cycle. Fabrication costs must be reduced and plant operation simplified. The design of a full MOX PWR core would enable the number of reactors devoted to plutonium recycling to be reduced and fuel zoning to be eliminated. This paper is a contribution to the feasibility studies for achieving such a core without fundamental modification of the current design. In view of the differences observed between uranium and plutonium characteristics it seems necessary to reconsider the safety of a MOX-fuelled PWR. Reduction of the control worth and modification of the moderator density coefficient are the main consequences of using MOX fuel in a PWR. The core reactivity change during a draining or a cooling is thus of prime interest. The study of core global draining leads to the following conclusion: only plutonium fuels of very poor quality (i.e. with low fissile content) cannot be used in a 900 MWe PWR because of a positive global voiding reactivity effect. During a cooling accident, like an spurious opening of a secondary-side valve, the hypothetical return to criticality of a 100% MOX core controlled by means of 57 control rod clusters (made of hafnium-clad B 4 C rods with a 90% 10 B content) depends on the isotopic plutonium composition. But safety criteria can be complied with for all isotopic compositions provided the 10 B content of the soluble boron is increased to a value of 40%. Core global draining and cooling accidents do not present any major obstacle to the feasibility of a 100% MOX PWR, only minor hardware modifications will be required. (author)

  11. The political parties and significant personalities of the Bessarabian Zemstvo (1869-1917

    Directory of Open Access Journals (Sweden)

    Valentin Tomuleţ

    2017-12-01

    Full Text Available This article focuses on some parties and significant personalities who worked in the Bessarabian institution of local self-government – Zemstvo (created in 1869 and contributed to the development of the province. The authors found that some nobles united and formed political parties. Parties of the Zemstvo were groups of persons related to the most influential families from Bessarabia. For some of them the Zemstvo served as a platform on which the nobles could solve their problems. It can be said that the Zemstvo was the “alter ego” of the Bessarabian nobility. As a result, in the political life of Bessarabia two main parties were formed – “Young Bessarabia” (“Molodaya Bessarabiya” and “Old Greek Party” (Starogrecheskaya”, which succeeded each other at the helm of power. In the early 1880s, the “Old Greek party” finally defeated its rival and gained full power in the Bessarabian Zemstvo administration. Counselors saw in the Bessarabian Zemstvo an important and reliable instrument for committing abuses. For example, the Head of the Orhei Zemstvo Council Cozac embezzled money from the Zemstvo budget. When the fact of the theft was uncovered, and this was written about in the press, Cozac shot himself. Each group of the nobles included not only people related to certain interest in economic and political life of Bessarabia, but also people related by kinship, acting in the family interests. In 1881-1884, 18 of the 52 provincial councelors were relatives: brothers Semigradov (4 people, brothers Krupensky, brothers Sinadino, brothers Dunca, brothers Cotruta (2 people. The Krupensky family was the most influential family in the Bessarabian Zemstvo. The publicist P. Krushevan wrote in this regard that the Krupensky clan usurped all the power in Bessarabia, and the Governor S. Urusov noted their importance in economic and political life of the province. Many members of the Zemstvo left their mark in the economic, political, and

  12. Building Partner Capacity: The Science Behind The Art

    Science.gov (United States)

    2016-12-01

    Brother , Defending Ourselves: The Iranian Intervention in Oman, 1972– 75,” 455. 170 Hughes, “A ‘Model Campaign’ Reappraised,” 296. 171 Geoffrey Warner ...164 Hughes, “A ‘Model Campaign’ Reappraised,” 296. 165 James F. Goode, “Assisting Our Brother , Defending Ourselves: The Iranian Intervention in Oman...Confrontation in the Arabian Peninsula,” 289; Goode, “Assisting Our Brother , Defending Ourselves: The Iranian Intervention in Oman, 1972–75,” 455

  13. Langenud Gorilla / Kertu Ruus

    Index Scriptorium Estoniae

    Ruus, Kertu, 1977-

    2008-01-01

    Ilmunud ka: Delovõje Vedomosti 24. sept. lk. 8-9. USA investeerimispanga Lehman Brothers tegevjuhist Dick Fuldist. Vt. samas: Richard S. Fuld: CV; Ameerika unistuste täitja: vendade investeerimispank; Taust; Kommenteerivad: Madis Toomsalu ja Jonathan Well

  14. 20 CFR 222.41 - Determination of relationship and support for parent.

    Science.gov (United States)

    2010-04-01

    ... RAILROAD RETIREMENT ACT FAMILY RELATIONSHIPS Relationship as Parent, Grandchild, Brother or Sister § 222.41... died or at the beginning of the period of disability, if the employee had a period of disability. (b...

  15. 15 CFR 80.4 - Signature of persons unable to sign their name.

    Science.gov (United States)

    2010-01-01

    ... information can be released upon receipt of a physician's sworn statement verifying the disability and the written request of a parent, brother, sister, child or a spouse. (Approved by the Office of Management and...

  16. 20 CFR 410.633 - Additional parties to the hearing.

    Science.gov (United States)

    2010-04-01

    ... OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Determinations of Disability, Other Determinations... hearing. A widow, child, parent, brother, sister, or representative of a decedent's estate, who makes a...

  17. James Blunt matuselaulude edetabeli tipus

    Index Scriptorium Estoniae

    2006-01-01

    Bereavement Registeri andmetel Suurbritannias matustel tellitavate laulude edetabelis: James Blunt "Goodbye My Lover", Robbie Williams "Angels", Jennifer Warnes ja Bill Medley "I've Had the Time Of My Life", Elton John "Candle in the Wind", Righteous Brothers "Unchained Melody"

  18. 20 CFR 10.7 - What forms are needed to process claims under the FECA?

    Science.gov (United States)

    2010-04-01

    ... Recurrence of Disability and Claim for Pay/ Compensation (4) CA-5 Claim for Compensation by Widow, Widower and/or Children (5) CA-5b Claim for Compensation by Parents, Brothers, Sisters, Grandparents, or...

  19. 20 CFR 416.1166a - How we deem income to you from your sponsor if you are an alien.

    Science.gov (United States)

    2010-04-01

    ... determine your eligibility for SSI benefits beginning with the month in which your disability or blindness... deemed to Mr. Bert and Mr. Davis. Each of the brothers is liable for rent in the boarding house (a...

  20. 47 CFR 97.509 - Administering VE requirements.

    Science.gov (United States)

    2010-10-01

    ..., grandchildren, stepchildren, parents, grandparents, stepparents, brothers, sisters, stepbrothers, stepsisters... accommodate an examinee whose physical disabilities require a special examination procedure. The administering VEs may require a physician's certification indicating the nature of the disability before determining...

  1. 38 CFR 21.374 - Authorization for travel of attendants.

    Science.gov (United States)

    2010-07-01

    ... severity of the veteran's disability. Attendants may only be used to enable a veteran to attend... or marriage is the veteran's (i) Spouse, (ii) Parent, (iii) Child, (iv) Brother, (v) Sister, (vi...

  2. 20 CFR 410.623 - Reconsideration; right to reconsideration.

    Science.gov (United States)

    2010-04-01

    ... AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Determinations of Disability, Other... reconsideration is filed, as provided in § 410.624, by an individual as a widow, child, parent, brother, sister...

  3. 78 FR 52719 - Tax Credit for Employee Health Insurance Expenses of Small Employers

    Science.gov (United States)

    2013-08-26

    ..., mother-in-law, brother-in-law, or a sister-in-law. A spouse is also considered a family member for this... employee is paid for vacation, holiday, illness, incapacity (including disability), layoff, jury duty...

  4. Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations

    NARCIS (Netherlands)

    Poulton, C.; Oegema, R.; Heijsman, D.; Hoogeboom, J.; Schot, R.; Stroink, H.; Willemsen, M.A.A.P.; Verheijen, F.W.; Spek, P. van der; Kremer, A.; Mancini, G.M.S.

    2013-01-01

    We present a neurodegenerative disorder starting in early childhood of two brothers consisting of severe progressive polyneuropathy, severe progressive cerebellar atrophy, microcephaly, mild epilepsy, and intellectual disability. The cause of this rare syndrome was found to be a homozygous mutation

  5. Predictors of future caregiving by adult siblings of individuals with intellectual and developmental disabilities.

    Science.gov (United States)

    Burke, Meghan M; Taylor, Julie Lounds; Urbano, Richard; Hodapp, Robert M

    2012-01-01

    With the growing life expectancy for individuals with intellectual and developmental disabilities, siblings will increasingly assume responsibility for the care of their brother or sister with intellectual and developmental disabilities. Using a 163-item survey completed by 757 siblings, the authors identified factors related to future caregiving expectations. Siblings expected to assume greater caregiving responsibility for their brother or sister with disabilities if they were female, had closer relationships with and lived closer to their brother or sister with intellectual and developmental disabilities, and were the lone sibling without a disability. Siblings who expected to assume higher levels of caregiving had parents who were currently more able to care for their brother or sister with disabilities. With a better understanding of who intends to fulfill future caregiving roles, support can be provided to these siblings.

  6. An Assessment of New Applications for Single-Crystal Piezoelectric Materials

    National Research Council Canada - National Science Library

    Veitch, Lisa

    1998-01-01

    Piezoelectricity was first discovered by the Curie brothers in 1880. During the 1940s, piezoelectric ceramic materials were first used in commercial devices, and new materials and other applications have continued to develop over the years...

  7. Sibling sex ratio of boys with gender identity disorder.

    Science.gov (United States)

    Zucker, K J; Green, R; Coates, S; Zuger, B; Cohen-Kettenis, P T; Zecca, G M; Lertora, V; Money, J; Hahn-Burke, S; Bradley, S J; Blanchard, R

    1997-07-01

    Sibling sex ratio (the ratio of brothers to sisters) was calculated for 444 boys with gender identity disorder (or with behaviors consistent with this diagnosis). The probands were ascertained from several researchers with expertise with this disorder and from the English language case report literature between 1938 and 1995. Among the probands with at least one sibling (N = 333), the results showed that boys with gender identity disorder had a significant excess of brothers to sisters, 131.1:100, when compared with the expected secondary sex ratio of 106:100. The excess of brothers replicated a previous study by Blanchard, Zucker, Bradley, and Hume (1995), in which the sibling sex ratio was 140.6:100. Further analyses showed that the probands were born later relative to their brothers than they were relative to their sisters. These findings are amenable to several psychosocial and biological explanations, which require further investigation.

  8. Uued heliplaadid / Koit Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Koit

    1999-01-01

    Uute heliplaatide tutvustus : Peshay "Miles From Home", kogumik "Essential Selection Presents Human Traffic", Great White "Can"t Get There From Here", Ratt "Ratt", RZA "The RZA Hits", Insane Clown Posse "The Amazing Jackal Brothers"

  9. Understanding your prostate cancer risk

    Science.gov (United States)

    ... older. Family history. Having a father, brother, or son with prostate cancer increases your risk. Having one immediate family member with prostate cancer doubles a man's own risk. A man who has 2 or ...

  10. Popmuusika / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2006-01-01

    Uutest heliplaatidest Yeah Yeah Yeahs "Show Your Bones", Cesaria Evora "Rogamar", Aqua Bassino "Rue De Paris", A-Rühm "Leegion", Prefuse 73 "Security Screenings", Bauchklang "Vocal Groove Project", Scala & Kolancy Brothers "Grezenlos"

  11. Pop / Lauri Tikerpe

    Index Scriptorium Estoniae

    Tikerpe, Lauri

    2005-01-01

    Heliplaatidest: Little Brother "The Minstrel Show", Jackson and his Computer Band "Smash", Matthew Herbert "Plat du Jour", Porn Sword Tobacco "Explains Freedom", Jamiroquai "Dynamite", Ryan Adams and the Cardinals "Jacksonville City Nights", The Dandy Warhols "Odditorium", Neil Young "Prairie Wind"

  12. Rapitav sõna : Igakuine hip-hopi infopunkt / Kozy

    Index Scriptorium Estoniae

    Kozy, pseud.

    1999-01-01

    Uutest heliplaatidest Snoop Dogg "No Limit Top Dogg", Public Enemy "There's A Poison Goin" On"", RZA "Hits", Missy Misdemeanor Elliott "Da Real World", Insane Clown Posse "The Amazing Jeckel Brothers"

  13. 42 CFR 51c.304 - Governing board.

    Science.gov (United States)

    2010-10-01

    ... employee of the center, or spouse or child, parent, brother or sister by blood or marriage of such an... procedures, salary and benefit scales, employee grievance procedures, and equal opportunity practices; (iii...

  14. Prostate Cancer Prevention

    Science.gov (United States)

    ... prostate cancer A man whose father, brother, or son has had prostate cancer has a higher-than- ... known if these drugs lower the risk of death from prostate cancer. The Prostate Cancer Prevention Trial ( ...

  15. 13 CFR 124.3 - What definitions are important in the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... functions of the firm. Immediate family member means father, mother, husband, wife, son, daughter, brother... (other than after death or incapacity). The pledge or encumbrance of stock or other ownership interest as...

  16. 42 CFR 488.301 - Definitions.

    Science.gov (United States)

    2010-10-01

    ..., stepbrother, or stepsister; father-in-law, mother-in-law, son-in-law, daughter-in-law, brother-in-law, or..., harm, impairment, or death to a resident. Misappropriation of resident property means the deliberate...

  17. v V V V V v

    Indian Academy of Sciences (India)

    . Wright Brothers first flight. •••• J . .... 1. 08 .......... -- (Credit: Courtesy of Special Collections and Archives,. Wright State University). Back Cover. (Colour scheme for cover by Jayant Roo). Wilbur Wright 11867 - 1912). Orville Wright 11871 - 1948).

  18. 13 CFR 127.102 - What are the definitions of the terms used in this part?

    Science.gov (United States)

    2010-01-01

    ... EDWOSBs. Immediate family member means father, mother, husband, wife, son, daughter, brother, sister, grandfather, grandmother, grandson, granddaughter, father-in-law, mother-in-law, son-in-law, and daughter-in...

  19. 28 CFR 58.4 - Qualifications for appointment as standing trustee and fiduciary standards.

    Science.gov (United States)

    2010-07-01

    ... individual who is related to the standing trustee as father, mother, son, daughter, brother, sister, uncle, aunt, first cousin, nephew, niece, husband, wife, father-in-law, mother-in-law, son-in-law, daughter-in...

  20. 20 CFR 641.841 - What policies govern nepotism?

    Science.gov (United States)

    2010-04-01

    ... requirement is followed. (c) For purposes of this section, “Immediate family” means wife, husband, son, daughter, mother, father, brother, sister, son-in-law, daughter-in-law, mother-in-law, father-in-law...

  1. 11 CFR 100.93 - Travel by airplane or other means of transportation.

    Science.gov (United States)

    2010-01-01

    ... member” of a candidate is the father, mother, son, daughter, brother, sister, husband, wife, father-in-law, or mother-in-law of the candidate. (h) Preemption. In all respects, State and local laws are...

  2. 76 FR 35371 - Proposed Modification of the Las Vegas, NV, Class B Airspace Area; Public Meetings

    Science.gov (United States)

    2011-06-17

    .... Comments: Send comments on the proposal, in triplicate, to: John Warner, Manager, Operations Support Group... Ruggiero, Support Manager Las Vegas, TRACON, 699 Wright Brothers Lane, Las Vegas, NV 89119; telephone: (702...

  3. Theatre Arts' Michael Anthony Williams appears in Jodie Foster's new film, The Brave One

    OpenAIRE

    Adams, Louise

    2007-01-01

    Virginia Tech Theatre Arts Visiting Instructor Michael Anthony Williams is in the cast of Jodie Foster's new movie, The Brave One, being released to theatres around the nation on Friday, Sept. 14, by Warner Brothers Studios.

  4. Anonymous letters? DNA and fingerprints technologies combined to solve a case.

    Science.gov (United States)

    Barbaro, A; Cormaci, P; Teatino, A; La Marca, A; Barbaro, A

    2004-12-02

    Two brothers, living in two different cities, received two different anonymous letters. We performed latent prints development and DNA research on the letters and also on a glass used by a cousin suspected to be the letters' sender.

  5. V cizích službách. Život a smrt pražského fundatisty

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2012-01-01

    Roč. 31, - (2012), s. 317-327 ISSN 0231-7443 Institutional support: RVO:68378076 Keywords : Brothers Hospitallers' Hospital * boy Choristers * Prague * 18th Century * boys and young men Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. ON THE TRAIL OF JOHN CALVIN'S PHILOSO- PHY OF LANGUAGE ...

    African Journals Online (AJOL)

    - portant but inadequate. .... This history should be kept alive in memory because it impresses on us the grace and patience of God with .... close bond between the brothers. Sem and Japheth, notwithstanding all the calamities caused by sin.13.

  7. 5 CFR 3201.106 - Employment of family members outside the Corporation.

    Science.gov (United States)

    2010-01-01

    ... SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE FEDERAL DEPOSIT INSURANCE CORPORATION § 3201.106... matter if the employer of the employee's spouse, child, parent, brother, sister, or a member of the...

  8. Gene-culture translation in the avoidance of sibling incest

    Science.gov (United States)

    Lumsden, Charles J.; Wilson, Edward O.

    1980-01-01

    A preliminary analysis is made of the relation between the epigenetic rules of brother-sister incest avoidance, which operate during individual development, and the frequency of occurrence of this form of incest among cultures. PMID:16592898

  9. Phenylketonuria

    Science.gov (United States)

    Phenylalanine plays a role in the body's production of melanin. The pigment is responsible for skin and hair color. Therefore, infants with the condition often have lighter skin, hair, and eyes than brothers or sisters ...

  10. Kuula. Kuu artist Carla Bruni. Kuu plaat / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2008-01-01

    Lauljast Carla Brunist. Heliplaatidest: "Mamma mia", The Feeling "Join With Us", The Chemical Brothers "Brotherhood", Pia Fraus "Ten Remixes of Yenissey", Katy Perry "One of the Boys", Lady Gaga "The Fame"

  11. Passion for Modern Art

    OpenAIRE

    Walter-Ris, Anja

    2010-01-01

    The story of the Nierendorf Gallery and the Nierendorf brothers exemplify the extremely important, however, often underestimated influence of modern art dealers on the development of single artists, whole art movements and thus of modern art history itself.

  12. Multiple Sclerosis, Personal Stories | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Multiple Sclerosis Personal Stories: Nicole Lemelle, Iris Young, Michael Anthony, ... something quite different for a person living with multiple sclerosis, such as his girlfriend's brother, Chuy. The more ...

  13. Uued plaadid

    Index Scriptorium Estoniae

    1999-01-01

    Uutest heliplaatidest Ivo Linna & Rock Hotel "Kõva ketas", Hendrik Sal-Saller "1994-1996", Chemical Brothers "Surrender", Mike & The Mechanics "M6", Bomfunk Mc"s "In Stereo", Jamiroquai "Synkronized"

  14. Plaadid : Pop & rock / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2002-01-01

    Uutest plaatidest Chemical Brothers "Come With Us", Air "Everybody Hetrz", "The Greatest Love Songs Ever", Nightlight Duo "Jäljed liival", closer To heaven ئ original Cast Recording, Sophie Ellis-Bextor "Read My Lips", Andreas Johnson "Deadly Happy"

  15. Plaadid / Heili Vaus-Tamm

    Index Scriptorium Estoniae

    Vaus-Tamm, Heili, 1961-

    2003-01-01

    Uutest plaatidest Andras Schiff "Goldberg Variations", Yes "Remixes", "Chill: Brasil 2", "The Fighting Temptations soundtrack", Wheatus "Hand Over Your Loved Ones", Peaches "Fatherfucker", Chemical Brothers "Singles 93-03"

  16. 32 CFR 751.5 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., snags, or stains on clothing. Claims that electrical or electronic devices were damaged by a power surge...) Spouse; (ii) Child or children; (iii) Father, mother, or both; (iv) Brother, sister, or both. (b...

  17. National Institute on Minority Health and Health Disparities

    Science.gov (United States)

    ... for both baby and mom. More Minorities and Mental Health: Moving Beyond the Stigma Mental illness is ... Science-Based Health & Wellness Resources NIH Información de salud Brother, You're on My Mind Toolkit Staying ...

  18. This is My Family

    OpenAIRE

    Yeğen, Hale Nur; Çetin, Merve

    2017-01-01

    Me and my family, Families poem, Mother-Father, Brother-Sister, Grandparents, Uncle-Aunt, Cousin, Family, Family handgame, My family tree, Activities (Three In a Family), Digital Games, A family poem, Quiz

  19. A new species of Hoplognathoca Suárez, 1962 from Central America and description of male of Hoplognathoca costarricensis Suárez, 1962 (Hymenoptera: Mutillidae).

    Science.gov (United States)

    Cambra, Roberto A T; Quintero, Diomedes A; Brothers, Denis J

    2014-11-14

    Hoplognathoca jinotega Cambra, Quintero & Brothers, sp. nov., female, from Nicaragua and Guatemala and the male of H. costarricensis Suárez, 1962 are described and illustrated. The genus Hoplognathoca is reported for the first time from Nicaragua. 

  20. Fulltext PDF

    Indian Academy of Sciences (India)

    . Wright Brothers first flight. •••• J . .... 1. 08 .......... -- (Credit: Courtesy of Special Collections and Archives,. Wright State University). Back Cover. (Colour scheme for cover by Jayant Roo). Wilbur Wright 11867 - 1912). Orville Wright 11871 - 1948).