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Sample records for bronchiolitis obliterans organizing

  1. Bronchiolitis Obliterans Organizing Pneumonia Induced by Minocycline

    OpenAIRE

    Shikuwa, Chieko; Kadota, Jun-ichi; Mukae, Hiroshi; Nagata, Towako; Kaida, Hideyuki; Ishii, Hiroshi; Ishimatsu, Yuji; Kohno, Shigeru

    2001-01-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) caused by minocycline (MINO). A 59- year-old man visited to our hospital because of flu-like symptoms. He had been treated with MINO for a few weeks for the skin eruption. The chest radiograph showed consolidations in both lung fields. He was admitted to our hospital for further examination. An elevation of lymphocyte percentage was seen in his bronchoalveolar lavage and a diagnosis of BOOP was confirmed by video-assiste...

  2. Another Face of Bronchiolitis Obliterans Organizing Pneumonia

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    Mark O Turner

    2003-01-01

    Full Text Available A 47-year-old man presented with an eight-day history of nonproductive cough and constitutional symptoms progressing to respiratory failure. High resolution computed tomography revealed a diffuse micronodular pattern and a ‘tree-in-bud’ pattern in the lower lung zones. Transbronchial biopsy showed features consistent with bronchiolitis obliterans organizing pneumonia (BOOP. After an initially difficult clinical course, the patient responded well to long term treatment with corticosteroids, including improvement of air flow obstruction. This case illustrates a variant of BOOP characterized by a comparatively acute onset, a component of proliferative bronchiolitis, an obstructive rather than restrictive pattern of pulmonary function testing and good clinical response to corticosteroid therapy.

  3. Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

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    E. Vandeix

    2012-01-01

    Full Text Available Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS. A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.

  4. Nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia: Report of a case

    OpenAIRE

    Fenton, Mark E; Rani Kanthan; Donald W Cockcroft

    2008-01-01

    Bronchiolitis obliterans organizing pneumonia due to nitrofurantoin has rarely been reported and is associated with poor outcomes. A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented.

  5. Nitrofurantoin-Associated Bronchiolitis Obliterans Organizing Pneumonia: Report of a Case

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    Mark E Fenton

    2008-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia due to nitrofurantoin has rarely been reported and is associated with poor outcomes. A case of nitrofurantoin-associated bronchiolitis obliterans organizing pneumonia responsive to drug withdrawal and corticosteroids is presented.

  6. Rituximab-Induced Bronchiolitis Obliterans Organizing Pneumonia

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    Ahmet B. Ergin

    2012-01-01

    Full Text Available Rituximab-induced lung disease (R-ILD is a rare entity that should be considered in patients treated with rituximab who present with dyspnea, fever, and cough, but no clear evidence of infection. A variety of pathologic findings have been described in this setting. Bronchiolitis obliterans organizing pneumonia (BOOP is the most common clinicopathologic diagnosis, followed by interstitial pneumonitis, acute respiratory distress syndrome (ARDS, and hypersensitivity pneumonitis. Prompt diagnosis and treatment with corticosteroids are essential as discussed by Wagner et al. (2007. Here we present a case of an 82-year-old man who was treated with rituximab for recurrent marginal zone lymphoma. After the first infusion of rituximab, he reported fever, chills, and dyspnea. On computed tomography imaging, he was found to have bilateral patchy infiltrates, consistent with BOOP on biopsy. In our patient, BOOP was caused by single-agent rituximab, in the first week after the first infusion of rituximab. We reviewed the relevant literature to clarify the different presentations and characteristics of R-ILD and raise awareness of this relatively overlooked entity.

  7. [Bronchiolitis obliterans with organized pneumonia: apropos 2 new cases].

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    Fernández Vázquez, E; Zamarrón Sanz, C; Palacios Bartolomé, A; Valle Vázquez, J M; Alvarez Dobaño, J M; Tumbeiro Novoa, M

    1992-12-01

    We present two cases of bronchiolitis obliterans organizing pneumonia (BOOP) with different clinical and radiological characteristics. In one case, the chest X-ray demonstrated bilateral migrating infiltrates. The pathology showed bronchiolar and intra-alveolar occupation by granulation tissue in both cases. It should be noted that both patients responded well to treatment with prednisone although alterations in gas exchange persisted in one case. PMID:1486169

  8. Bronchiolitis obliterans organizing pneumonia after irradiation therapy for breast cancer

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    Kitagawa, Satoshi; Aoshima, Masahiro; Ohmagari, Norio; Tada, Hiroshi; Chohnabayashi, Naohiko; Suzuki, Kohyu [Saint Luke' s International Hospital, Tokyo (Japan)

    2003-02-01

    We report three cases of bronchiolitis obliterans organizing pneumonia (BOOP) that developed after irradiation therapy following breast cancer. All patients presented with cough and fever for 3 to 10 months after the completion of irradiation. Chest radiographs and computed tomography (CT) in all three patients demonstrated a consolidation outside the irradiated fields. Their laboratory data revealed increased C-reactive protein and increased erythrocyte sedimentation rates. Transbronchial lung biopsy was performed in all patients, and plugs of granulation tissue in the bronchioles and interstitial infiltration by mononuclear cells were found. Corticosteroid treatment resulted in rapid clinical improvement. BOOP was diagnosed from the histological and clinical findings. Although the etiology of BOOP still remains unknown, there may be a subgroup of such patients in whom the BOOP is induced by irradiation for breast cancer. These cases were assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  9. Bronchiolitis obliterans organizing pneumonia associated with achalasia: A case report.

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    Malek, Farhad; Nobakhat, Hossein; Hemmati, Hamidreza

    2016-01-01

    There is little mention in the literature about achalasia as an etiologic factor of Bronchiolitis obliterans organizing pneumonia (BOOP). In this study, a case of BOOP, which appeared to be secondary to achalasia is reported. A 35 years old man present with nonproductive cough, chills and fever from two month ago. Due to permanent consolidation in mid zone of right lung and unresponsive to antibiotics, transthoracic needle biopsy was done that showed BOOP. Due to esophageal dilatation in chest computerized tomography (CT) scan, endoscopy and esophagogram was done that showed achalasia. After surgery and a course of corticosteroid the patient condition became well. This report demonstrates that achalasia may be associated with BOOP. PMID:27408784

  10. Diffuse micronodular pattern of bronchiolitis obliterans organizing pneumonia: a case report

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    Lee, In Jae; Jang, Seung Hun; Min, Kwang Seon; Whang, Im Kyung; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang (Korea, Republic of)

    2006-10-15

    The typical radiographic findings of bronchiolitis obliterans organizing pneumonia (BOOP) are known to be patchy air-space consolidation that is often subpleural, and with or without ground-glass opacities. However, there are scant radiologic reports about the micronodular pattern of BOOP. We report here on a case of BOOP that manifested as diffusely scattered ill-defined centrilobular micronodules on HRCT.

  11. Bronchiolitis obliterans organizing pneumonia after tangential beam irradiation to the breast. Discrimination from radiation pneumonitis

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    Nambu, Atsushi; Ozawa, Katsura; Kanazawa, Masaki; Miyata, Kazuyuki [Kofu Municipal Hospital (Japan); Araki, Tsutomu; Ohki, Zennosuke [Yamanashi Medical Coll., Tamaho (Japan)

    2002-06-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) secondary to tangential beam irradiation to the breast, which occurred seven months after the completion of radiotherapy. Although radiation pneumonitis is an alternative consideration, BOOP could be differentiated from it by its relatively late onset and extensive distribution, which did not respect the radiation field. This disease should always be kept in mind in patients with a history of tangential beam irradiation to the breast. (author)

  12. Polyarteritis Nodosa and Bronchiolitis Obliterans with Organizing Pneumonia, an Unusual Association

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    Kaberi Dasgupta; A Kevin Watters; Arnold Zidulka

    1997-01-01

    Bronchiolitis obliterans and organizing pneumonia (BOOP) is an inflammatory, fibrotic disorder of the small airways, alveoli and pulmonary intersitium. Often idiopathic and usually benign, this condition may cause dyspnea and influenza-like symptoms. Polyarteritis nodosa (PAN) is a small and medium vessel vasculitis, which usually involves the kidney and other viscera but rarely results in vasculitis of the lungs. This is the second case of BOOP associated with PAN reported in the literature....

  13. Bronchiolitis obliterans organizing pneumonia after radiation therapy for lung cancer: a case report.

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    Falcinelli, Lorenzo; Bellavita, Rita; Rebonato, Alberto; Chiari, Rita; Vannucci, Jacopo; Puma, Francesco; Aristei, Cynthia

    2015-01-01

    Bronchiolitis obliterans organizing pneumonia (BOOP), also known as cryptogenic organizing pneumonia, has mainly been described in patients with breast cancer who received radiotherapy after breast-conserving surgery. In this rare case, a 70-year-old man with left apical squamous lung cancer developed BOOP after radiotherapy and only one cycle of concomitant chemotherapy.This case report draws attention to the development of this syndrome in the unusual setting of lung cancer, advising prompt steroid treatment when diagnostic images reveal the characteristic signs of the disease. PMID:25908030

  14. Bronchiolitis obliterans organizing pneumonia after adjuvant thoracic radiotherapy for breast cancer. A case report

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    Yamada, Katsuyasu; Ogasawara, Tomohiko; Akita, Yuko; Miyazaki, Mikinori; Inukai, Akihiro; Shinjo, Keiko; Suzuki, Masayuki [Nagoya Daini Red Cross Hospital (Japan)

    2001-02-01

    We report a case of recurrent cough and migratory pulmonary infiltrates in a 55-year-old woman after adjuvant thoracic radiotherapy for breast cancer. The pulmonary infiltrates were initially limited to the area adjacent to the irradiated breast, but later migrated to the opposite lung. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was made using transbronchial biopsy, which disclosed intraluminal fibrosis in the distal airspace, together with a radiographic appearance typical of BOOP. This case was assumed to be in a series of reported cases of BOOP primed by radiotherapy. (author)

  15. Polyarteritis Nodosa and Bronchiolitis Obliterans with Organizing Pneumonia, an Unusual Association

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    Kaberi Dasgupta

    1997-01-01

    Full Text Available Bronchiolitis obliterans and organizing pneumonia (BOOP is an inflammatory, fibrotic disorder of the small airways, alveoli and pulmonary intersitium. Often idiopathic and usually benign, this condition may cause dyspnea and influenza-like symptoms. Polyarteritis nodosa (PAN is a small and medium vessel vasculitis, which usually involves the kidney and other viscera but rarely results in vasculitis of the lungs. This is the second case of BOOP associated with PAN reported in the literature. Knowledge of this association is likely to be of value because an undiagnosed vasculitis can rapidly become fatal.

  16. Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma

    International Nuclear Information System (INIS)

    Common complications of thoracic radiotherapy include esophagitis and radiation pneumonitis. However, it is important to be aware of uncommon post-radiotherapy complications such as bronchiolitis obliterans organizing pneumonia (BOOP). We report on two patients with carcinoma of the breast who developed an interstitial lung disease consistent with BOOP. BOOP responds to treatment with corticosteroids and the prognosis is generally good despite of the need for long-term administration of corticosteroids as relapses can occur during tapering of steroids. This report provides guidelines for the evaluation and treatment of patients with pulmonary infiltrates after radiotherapy

  17. Successful treatment of Bronchiolitis obliterans with organizing pneumonia in dialysis patient

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    Vivek B Kute

    2012-01-01

    Full Text Available A 42-year-old end stage renal disease (ESRD patient was admitted with fever, anorexia, malaise, non-productive cough, and dyspnea, of one-week duration. Multiple cultures of the blood, sputum, and urine were negative for microorganisms. The possibility of bronchiolitis obliterans with organizing pneumonia (BOOP was considered when patient with pulmonary infiltrate did not respond to conventional antibiotic therapy and frequent hemodyalisis. High-resolution computed tomography of the chest revealed patchy air-space consolidation, ground-glass opacities, and small nodular opacities, predominantly located at the peripheral part of the lungs. Cultures and stains of bronchoalveolar lavage (BAL specimen and bronchoscopic biopsy of lung tissue were negative for organisms [bacteria, mycobacterium tuberculosis, PCP, fungus, and atypical organism] and showed evidence of BOOP. Patient recovered completely with early diagnosis and treatment with steroids and underwent successful renal transplantation with wife as donor without postoperative complication and relapse.

  18. Pulmonary radiation injury manifested by signs of bronchiolitis obliterans with organizing pneumonia after postoperative breast cancer radiotherapy

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    Ogata, Kenichi; Shibata, Kazumi; Nishio, Tetsuo [Kitakyusyu Municipal Medical Center, Fukuoka (Japan); Kawarada, Yuji; Hara, Nobuyuki

    1999-12-01

    A 67-year-old woman underwent surgery for cancer of both breast (right: mastectomy, left: conserving surgery), and received 60 Gy radiation to the left postoperative breast. Three months later, cough and fever developed. A chest radiograph demonstrated infiltrative shadows in the left lung field. Transbronchial lung biopsy specimens disclosed organizing exudates in the alveolar spaces and bronchioles. After treatment with prednisolone, the clinical symptoms and radiographic infiltrates disappeared. This was a case of pulmonary radiation injury pathologically manifested by signs of bronchiolitis obliterans with organizing pneumonia. (author)

  19. A case of radiation pulmonary injury simulating bronchiolitis obliterans organizing pneumonia following postoperative radiotherapy for breast cancer

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    Katoh, Toshiyuki; Iwata, Masaru; Yoshida, Norio; Katagiri, Akira; Takeda, Naoya [Kariya General Hospital, Aichi (Japan)

    2001-09-01

    A 57-year-old female underwent conservative surgery for a left sided breast cancer, and received 48 Gy postoperative radiation therapy. One year later, a chest CT scan disclosed bilateral patchy ground glass opacities. She had no subjective symptom. These abnormal opacities disappeared spontaneously without any treatment. We considered this was a radiation lung injury simulating bronchiolitis obliterans organizing pneumonia. We emphasize that the symptomless and spontaneous resolution of this type of lung injury should be kept is mind. (author)

  20. Two cases of bronchiolitis obliterans organizing pneumonia syndrome after the radiation of breast-conserving therapy

    International Nuclear Information System (INIS)

    Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a recently reported complication of the adjuvant radiotherapy of breast-conserving surgery. We report two cases of BOOP syndrome in 100 patients who underwent breast-conserving therapy. A 75 year-old woman had a cough 3 months after radiation therapy for cancer of the left breast. Chest radiography and computed tomography showed consolidation with air bronchograms in the upper left lung. Transbronchial lung biopsy showed lymphocyte infiltration and fibrosis in the alveoli. A 45-year old woman with bilateral breast cancer had a cough and palpitations for 3 month after radiation therapy for cancer of the right breast. Chest radiography and computed tomography showed consolidation in upper and middle fields of the left lung. Transbronchial lung biopsy showed granulation formation in the alveolar duct, which is a typical feature of BOOP. The symptoms and radiographic findings improved with oral administration of prednisolone. BOOP syndrome may occur as a complication of breast-conserving therapy. (author)

  1. Two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer

    International Nuclear Information System (INIS)

    We report two cases of bronchiolitis obliterans organizing pneumonia (BOOP) induced radiotherapy after surgery of breast cancer. One of the patients was a 58-year-old woman. She underwent a conserving surgery for bilateral breast cancers, and received radiation therapy to the remaining part of bilateral breasts. Two months after the termination of irradiation, cough, fever and general fatigue developed. We clinically diagnosed this case as BOOP after radiation therapy. After initiation of oral steroid therapy, the clinical symptoms and radiographic findings disappeared. Another patient was a 57 year-old woman. She underwent radical mastectomy for right breast cancer. A month after the operation, she suffered from local recurrence, so radiation therapy to the thoracic wall was performed. After irradiation, resection of the thoracic wall lesion was performed because of malignancy from local skin biopsy specimen. Two months after the termination of irradiation, cough, dyspnea and fever developed. We clinically diagnosed this case as radiation-induced BOOP by bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB) findings. After an initiation of steroid therapy, the clinical symptoms and radiographic findings disappeared. It is important to be aware of BOOP as a complication in the patient who was given radiation after surgery of breast cancer. (author)

  2. Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?

    International Nuclear Information System (INIS)

    In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases. The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated. Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP. For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance. (author)

  3. Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

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    Ching-Chang Cheng

    2011-01-01

    Full Text Available Bronchiolitis obliterans organizing pneumonia (BOOP is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS, typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2 was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs, extracellular collagen matrix (ECM deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (<.05. Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.

  4. Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?

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    Mihara, Naoki; Johkoh, Takeshi [Osaka Univ., Suita (Japan). Medical School; Ichikado, Kazuya (and others)

    2000-10-01

    In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases. The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated. Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP. For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance. (author)

  5. Two cases of bronchiolitis obliterans organizing pneumonia syndrome after the radiation of breast-conserving therapy

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    Komuro, Youko; Nakagomi, Hiroshi; Akaike, Hidenori; Chiba, Shigehiro; Miyashita, Yoshihiro; Obu, S.; Yamaguchi, Motoshi; Oyama, Toshio [Yamanashi Prefectural Central Hospital, Kofu (Japan)

    2001-12-01

    Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a recently reported complication of the adjuvant radiotherapy of breast-conserving surgery. We report two cases of BOOP syndrome in 100 patients who underwent breast-conserving therapy. A 75 year-old woman had a cough 3 months after radiation therapy for cancer of the left breast. Chest radiography and computed tomography showed consolidation with air bronchograms in the upper left lung. Transbronchial lung biopsy showed lymphocyte infiltration and fibrosis in the alveoli. A 45-year old woman with bilateral breast cancer had a cough and palpitations for 3 month after radiation therapy for cancer of the right breast. Chest radiography and computed tomography showed consolidation in upper and middle fields of the left lung. Transbronchial lung biopsy showed granulation formation in the alveolar duct, which is a typical feature of BOOP. The symptoms and radiographic findings improved with oral administration of prednisolone. BOOP syndrome may occur as a complication of breast-conserving therapy. (author)

  6. Bronchiolitis obliterans organizing pneumonia in a case of multiple myeloma: an unusual association and discussion

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    Ramita Sarkar

    2014-12-01

    Full Text Available A male patient with respiratory distress for the last 2 months followed by gradual onset drowsiness and disorientation for the last 4-5 days is presented. On investigation he was found to be suffering from multiple myeloma (MM with features of hypercalcemia, lytic bone lesions, renal compromise and anemia complicated by meningoencephalitis. He was also found to be inflicted with bronchiolitis obliterans organizing pneumonia (BOOP as diagnosed by chest computerized tomography and transbronchial biopsy. Whether this association is sporadic or has some pathophysiological basis still remains to be discovered, though recurrent pneumonias due to immunosuppression in MM may be a possible etiopathological factor. The patient was stabilized and discharged on request but he presented again after 2 months with features of hypercalcemia in spite of getting a dose of zolendronate during the previous admission. This time he was given prednisolone and melphalan and was discharged in a stable condition after being counseled for follow-up visits. [J Exp Integr Med 2014; 4(4.000: 227-231

  7. Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a

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    Ronaldo Soares Martins

    2012-10-01

    Full Text Available The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon alfa-2a and ribavirin. The lung biopsy confirmed the diagnosis of a bronchiolitis obliterans organizing pneumonia (BOOP. Corticotherapy was initiated, with clinical and radiological improvement. This paper aims to advise physicians to this occasional, though severe, adverse event related to hepatitis C virus (HCV treatment.

  8. 闭塞性细支气管机化性肺炎%Bronchiolitis obliterans organizing pneumonia

    Institute of Scientific and Technical Information of China (English)

    卢宏柱; 赵亮

    2011-01-01

    @@ 闭塞性细支气管机化性肺炎(bronchiolitis obliterans organizing pneumonia,BOOP)是一个临床病理术语,其特征是以细支气管腔、肺泡管以及一些肺泡有肉芽组织形成,伴有间质和气腔内不同程度的单核细胞和泡沫巨噬细胞的浸润[1-2].

  9. Bronchiolitis Obliterans Organizing Pneumonia as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case Report and Literature Review

    Science.gov (United States)

    Wang, Hung-Ping; Chen, Chun-Ming; Chen, Yih-Yuan; Chen, Wei

    2016-01-01

    The etiology of bronchiolitis obliterans organizing pneumonia (BOOP) remains controversial. While it has been reportedly associated with several connective tissue disorders, there are only rare reports of BOOP associated with systemic lupus erythematosus (SLE). Herein, we report a 56-year-old female patient who presented with dyspnea on exertion, cough, fever, and joint pain of her left wrist and fingers as initial symptoms. Laboratory tests revealed positivity for anti-nuclear antibody, anti-Ro, and anti-double strand DNA antibody. In this case, the patient with SLE had respiratory illness as the initial symptom due to BOOP in the absence of clear etiology. The diagnosis of BOOP was confirmed by thoracic surgery biopsy. Her respiratory symptoms and radiologic findings significantly improved following prednisolone treatment. PMID:27200095

  10. Migratory pneumonitis similar to bronchiolitis obliterans organizing pneumonia after conservative treatment of breast cancer. A case report

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    Matsuura, Kanji; Hirokawa, Yutaka; Matsuura, Akiko; Akagi, Yukio; Ito, Katsuhide [Hiroshima Univ. (Japan). School of Medicine

    1999-07-01

    We report the case of a 63-year-old woman who developed cough and fever with migratory lung infiltrates three months after completion of right breast irradiation following conservative surgery. Lung infiltrates were initially localized in the irradiated area, but later spread to unirradiated areas in both lungs. No cause of migratory pneumonitis other than irradiation was found, and we clinically diagnosed this case as radiation-induced migratory pneumonitis similar to Bronchiolitis Obliterans Organizing Pneumonia(BOOP), without lung biopsy. Steroid therapy resulted incomplete resolution of lung infiltrates. The reported case clearly differed from typical radiation pneumonitis. We suggest that lung irradiation might trigger the development of migratory pneumonitis with a clinical pattern similar to that of BOOP. (author)

  11. Bronchiolitis obliterans organising pneumonia simulating bronchial carcinoma

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    Murphy, J.; Flower, C. [Department of Radiology, Addenbrooke`s Hospital, University of Cambridge Teaching Hospital (United Kingdom); Schnyder, P. [Department of Radiology, University Hospital, Lausanne (Switzerland); Herold, C. [Department of Radiology, University Hospital of Vienna (Austria)

    1998-09-01

    Idiopathic bronchiolitis obliterans organising pneumonia (BOOP) is an uncommon but well-recognised condition that usually presents radiologically as bilateral multifocal patchy areas of consolidation on the chest radiograph and on computed tomography (CT). Five cases are described in which the presenting feature was that of a solitary pulmonary nodule. Four of these nodules showed evidence of cavitation and three patients presented with haemoptysis. In all cases the appearances closely resembled bronchial carcinoma. (orig.) With 5 figs., 21 refs.

  12. Bronquiolitis obliterante con neumonía organizada y enfermedad de Crohn Bronchiolitis obliterans organizing pneumonia and Crohn’s disease

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    P. Gil-Simón

    2008-03-01

    Full Text Available Las manifestaciones extraintestinales respiratorias en la enfermedad inflamatoria intestinal (EII son excepcionales. Presentamos un caso de bronquiolitis obliterante con neumonía organizada (BONO en paciente con enfermedad de Crohn, en remisión clínica sin tratamientos farmacológicos.Extraintestinal respiratory manifestations in inflammatory bowel disease (IBD are rare. We present a case of bronchiolitis obliterans organizing pneumonia (BOOP in a patient with Crohn's disease, with clinical remission with no drug therapy.

  13. Bronchiolitis obliterans from exposure to incinerator fly ash.

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    Boswell, R T; McCunney, R J

    1995-07-01

    Inhalation of toxic substances in the workplace can result in a variety of respiratory disorders. One relatively rare sequela of the inhalation of toxic fumes is bronchiolitis obliterans, a condition characterized by fibrosis and narrowing of the small airways. Several substances have been reported to cause bronchiolitis obliterans, including ammonia, chlorine, hydrogen fluoride, hydrogen sulfide, nitrogen dioxide, ozone, phosgene, and other irritant fumes. Little has been reported on the pulmonary effects of fly ash produced by the incineration of coal and oil. We report a case of bronchiolitis obliterans with a component of partially reversible airway obstruction in a 39-year-old male occupationally exposed to incinerator fly ash. PMID:7552470

  14. [A case of bronchiolitis obliterans organizing pneumonia: diagnostic utility of bronchoalveolar lavage and CT scan].

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    Hyakudo, T; Yoshii, C; Nikaido, Y; Yokosaki, Y; Nagata, N; Nakata, H; Kido, M

    1994-08-01

    A 54-year-old female was admitted to our hospital because of abnormal shadows on chest X-ray at annual checkup. She complained of dyspnea on exertion. Chest X-ray findings showed an increase in density at the bilateral lower lung fields and unclearness of the silhouette of the heart and the diaphragm. CT scan findings revealed irregular opacities of various density with many small cystic changes and air bronchograms and air bronchiolograms. The pulmonary function test showed restrictive ventilatory disturbance and reduced diffusing capacity. BALF findings revealed an increase in the total cell count, an increase in the percentage of lymphocytes and a decrease in the OKT4+/OKT8+ ratio. TBLB specimen showed infiltration of mononuclear cells in alveolar septa and organizing exudate in alveolar ducts. These findings suggested a diagnosis of BOOP rather than IPF, and an open lung biopsy was performed. Open lung biopsy specimen showed obstructive bronchiolitis with polypoid granulation tissue and thickening of alveolar septa with infiltration of mononuclear cells, and she was diagnosed as having BOOP. She responded well to corticosteroid and is free from any abnormalities on chest X-ray, CT scan and pulmonary function test at present. Analysis of BALF and CT scan findings are useful for the differential diagnosis of BOOP and IPF. PMID:7807756

  15. Bronchiolitis Obliterans (BO: HRCT findings in 20 patients

    Directory of Open Access Journals (Sweden)

    Youssriah Yahia Sabri

    2014-03-01

    Conclusion: High-resolution CT is currently superior as an imaging modality in diagnosis of bronchiolitis obliterans, however, diagnosis of BO requires exclusion of other causes of chronic airway obstruction.

  16. Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome in breast cancer patients is associated with age

    International Nuclear Information System (INIS)

    Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a rarely observed phenomenon characterized by infiltration of the lungs outside of the radiation field, differentiating it from radiation pneumonitis (RP).The risk factors for radiation-induced BOOP (RT-BOOP) remain unclear and controversial. We retrospectively analyzed the incidence and risk factors for RT-BOOP associated with radiation therapy (RT) after breast conserving surgery (BCS) and post-mastectomy radiation therapy (PMRT). We analyzed 1,176 breast cancer patients treated with RT after BCS or PMRT between March 2005 and September2008 at the cancer institute hospital of the Japanese foundation for cancer research. Chest radiographs were routinely obtained every three to six months for at least 12 months after surgery, as well as when the patients experienced respiratory symptoms or fever. RT-BOOP syndrome was diagnosed in 16patients (1.4%), including12BCS patients (1.3%) and four PMRT patients (1.8%). An older age (≥52 years old) was significantly associated with the incidence of RT-BOOP syndrome in a univariate analysis (p =0.023). The type of treatment (BCS or PMRT) and irradiated lung volume at 20 Gy (V20) were not significantly associated with the incidence of RT-BOOP syndrome in the entire patient cohort. In the multivariate analysis, age and smoking were the significant factor associated with RT-induced BOOP syndrome (p =0.044 and 0.049, respectively). RT-BOOP syndrome was a rarity, and the incidence for BCT cases was similar to that for PMRT cases. The irradiated lung volume was not significantly associated with RT-BOOP syndrome. An older age can predict the incidence of RT-BOOP syndrome

  17. Saddle pulmonary embolus and bronchiolitis obliterans with organizing pneumonia develop simultaneously after first cyclophosphamide, methotrexate, 5FU chemotherapy for breast cancer.

    Science.gov (United States)

    Al-Hameed, Fahad M

    2015-06-01

    A 62-year-old woman underwent a right mastectomy with axillary node dissection for a poorly differentiated ductal carcinoma. One month later, she underwent a left nephrectomy for a renal cell carcinoma. Two weeks after, she received her first cycle of cyclophosphamide, methotrexate, and 5FU (CMF) as a part of her breast cancer treatment. We describe an unusual case of non-occlusive saddle pulmonary embolus with extensive bilateral deep vein thrombosis and severe bronchiolitis obliterans with organizing pneumonia developing simultaneously after the first CMF chemotherapy for breast cancer. PMID:25987120

  18. Lung transplantation for bronchiolitis obliterans syndrome after allo-SCT

    DEFF Research Database (Denmark)

    Holm, A M; Riise, Gerdt; Hansson, Leif Helmuth;

    2013-01-01

    Chronic GVHD (cGVHD) associated bronchiolitis obliterans syndrome (BOS) is a serious complication after allo-SCT, and lung transplantation (LTx) may be the ultimate treatment option. To evaluate this treatment, data on all patients with LTx after allo-SCT ever performed in Sweden, Norway, Denmark...

  19. Thionyl-chloride-induced lung injury and bronchiolitis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    Konichezky, S.; Schattner, A.; Ezri, T.; Bokenboim, P.; Geva, D. (Kaplan Hospital, Rehovot (Israel))

    1993-09-01

    Thionyl-chloride (TCl) is used in the manufacture of lithium batteries, producing SO2 and HCl fumes on contact with water. We report two cases of accidental TCl exposure resulting in lung injury that may vary from a relatively mild and reversible interstitial lung disease to a severe form of bronchiolitis obliterans causing, after a latent period, an acute/chronic respiratory failure as well as other complications (spontaneous pneumothorax and bronchopleural fistula), previously unreported in TCl fume inhalation.

  20. Are we near to an effective drug treatment for bronchiolitis obliterans?

    OpenAIRE

    Verleden, Geert; Vos, Robin; Dupont, Lieven; Van Raemdonck, Dirk; Vanaudenaerde, Bart; Verleden, Stijn

    2014-01-01

    Lung transplantation remains the only effective therapeutic option for well-selected patients with end-stage (cardio) pulmonary diseases such as emphysema, cystic fibrosis, lung fibrosis and pulmonary arterial hypertension. Although the results have improved lately, the long-term survival is still far behind other organ transplantations. This is mainly due to the development of chronic lung allograft dysfunction (CLAD), with bronchiolitis obliterans (BO) being the most frequent manifestation ...

  1. Performance of long-term CT monitoring in diagnosing bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Berstad, Audun E. [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)]. E-mail: a.e.berstad@medisin.uio.no; Aalokken, Trond Mogens [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Kolbenstvedt, Alf [Department of Radiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway); Bjortuft, Oystein [Department of Thoracic Medicine, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo (Norway)

    2006-04-15

    Aim: The purpose of the study was to evaluate the ability of CT, including expiratory scans with minimum intensity projection in predicting the development of bronchiolitis obliterans syndrome after lung transplantation. Materials and methods: Forty consecutive patients, 29 bilateral and 11 single lung transplanted, were followed-up with regular scans for a median of 36 months. Air trapping was evaluated on expiratory scans constructed from two short spiral scans with minimum intensity projection-technique, one at the level of the carina and the other midway between the right diaphragm and the carina. Air trapping was scored on a 16-point scale. Bronchiolitis obliterans syndrome was diagnosed according to established clinical criteria and quantified spirometrically. Results: Bronchiolitis obliterans syndrome developed in 17 patients (43%) after a median of 12 months. Air trapping and bronchiectasis was seen before the diagnosis of bronchiolitis obliterans syndrome in only two and one patient, respectively. Interobserver agreement for air trapping score was good (kappa = 0.65). Air trapping scores performed significantly better than that achieved by chance alone in determining the presence of bronchiolitis obliterans syndrome (P = 0.0025). An air trapping score of 4 or more provided the best results with regard to sensitivity and specificity in diagnosing bronchiolitis obliterans syndrome. The sensitivity, specificity, positive and negative predictive values of an air trapping of 4 or more in the diagnosis of bronchiolitis obliterans syndrome were 77, 74, 68 and 81%, respectively. Conclusion: Expiratory CT scans with minimum intensity projection-reconstruction did not predict the development of bronchiolitis obliterans syndrome in most patients. The findings seriously limit the clinical usefulness of long-term CT monitoring for diagnosing bronchiolitis obliterans syndrome after lung transplantation.

  2. Linear opacities on HRCT in bronchiolitis obliterans organising pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, J.M.; Flower, C.D.R. [Dept. of Radiology, Addenbrookes Hospital, Univ. of Cambridge (United Kingdom); Schnyder, P.; Leuenberger, P. [Depts. of Radiology and Medicine, University Hospital, CHUV, Lausanne (Switzerland); Verschakelen, J. [Dept. of Radiology, University Hospital, Leuven (Belgium)

    1999-07-01

    The aim of this study was to report the high-resolution computed tomography (HRCT) appearances of linear opacities that may occur in isolation or in combination with other changes in bronchiolitis obliterans organising pneumonia (BOOP). Eleven patients with BOOP and linear opacities on HRCT were identified at three independent teaching hospitals. The HRCT images and clinical course of each patient were reviewed. Two distinct types of linear opacity were identified. The type-1 opacity extended in a radial manner along the line of the bronchi towards the pleura and was usually intimately related to bronchi. The type-2 opacity occurred in a sub-pleural location and bore no relationship to the bronchi. Both types occurred most commonly in the lower lobes, frequently were associated with multi-focal areas of consolidation and usually completely resolved with treatment. There was no associated bronchiectasis, irreversible volume loss or a reticular or honeycomb pattern. In 2 patients linear opacities were the sole abnormality on HRCT. Bronchiolitis obliterans organising pneumonia may occur in a pure ''linear form'' or HRCT may demonstrate linear opacities in addition to multi-focal consolidation. (orig.)

  3. Bronchiolitis obliterans organising pneumonia associated with the use of nitrofurantoin.

    Science.gov (United States)

    Cameron, R J; Kolbe, J; Wilsher, M L; Lambie, N

    2000-03-01

    The spectrum of nitrofurantoin lung injury continues to widen. The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury. The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin. Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced. The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP. We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.

  4. Advances in Understanding Bronchiolitis Obliterans After Lung Transplantation.

    Science.gov (United States)

    Verleden, Stijn E; Sacreas, Annelore; Vos, Robin; Vanaudenaerde, Bart M; Verleden, Geert M

    2016-07-01

    Bronchiolitis obliterans syndrome (BOS) remains a major complication after lung transplantation, causing significant morbidity and mortality in a majority of recipients. BOS is believed to be the clinical correlate of chronic allograft dysfunction, and is defined as an obstructive pulmonary function defect in the absence of other identifiable causes, mostly not amenable to treatment. Recently, it has become clear that BOS is not the only form of chronic allograft dysfunction and that other clinical phenotypes exist; however, we focus exclusively on BOS. Radiologic findings typically demonstrate air trapping, mosaic attenuation, and hyperinflation. Pathologic examination reveals obliterative bronchiolitis lesions and a pure obliteration of the small airways (< 2 mm), with a relatively normal surrounding parenchyma. In this review, we highlight recent advances in diagnosis, pathologic examination, and risk factors, such as microbes, viruses, and antibodies. Although the pathophysiological mechanisms remain largely unknown, we review the role of the airway epithelium and inflammation and the various experimental animal models. We also clarify the clinical and therapeutic implications of these findings. Although significant progress has been made, the exact pathophysiological mechanisms and adequate therapy for posttransplantation BOS remain unknown, highlighting the need for further research to improve long-term posttransplantation BOS-free and overall survival. PMID:27212132

  5. Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans.

    Science.gov (United States)

    Tanou, Kalliopi; Xaidara, Athina; Kaditis, Athanasios G

    2015-05-01

    Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans. PMID:25682945

  6. Bronchiolitis obliterans after allogenic bone marrow transplantation: HRCT findings

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jung Im; Jung, Won Sang; Hahn, Seong Tai; Park, Seog Hee [St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of); Min, Chang Ki; Kim, Chun Choo [College of Medicine, The Catholic University, Seoul (Korea, Republic of)

    2004-06-15

    To evaluate the high resolution computed tomography (HRCT) findings of bronchiolitis obliterans (BO) after bone marrow transplantation (BMT). During the past three years, 11 patients were diagnosed as having BO after BMT when they developed irreversible air flow obstruction, with an FEV{sub 1} value of less than 80% of the baseline value, without any clinical evidence of infection. All 11 patients underwent HRCT, of whom eight also underwent follow-up HRCT. The HRCT images were assessed retrospectively for the presence of decreased lung attenuation, segmental or subsegmental bronchial dilatation, diminution of peripheral vascularity, centrilobular nodules, and branching linear structure on the inspiratory images. The lobar distribution of the decreased lung attenuation and bronchial dilatation was also examined. The presence of air trapping was investigated on the expiratory images. The interval changes of the HRCT findings were evaluated in those patients who had follow-up images. Abnormal HRCT findings were present in all cases; the most common abnormalities were decreased lung attenuation (n=11), subsegmental bronchial dilatation (n=6), diminution of peripheral vascularity (n=6), centrilobular nodules or branching linear structure (n=3), and segmental bronchial dilatation (n=3). Expiratory air trapping was noted in all patients. The decreased lung attenuation and bronchial dilatations were more frequent or extensive in the lower lobes. Interval changes were found in all patients with follow-up HRCT: increased extent of decreased lung attenuation (n=7); newly developed or progressed bronchial dilatation (n=4); and increased lung volume (n=3). HRCT scans are abnormal in patients with BO, with the most commonly observed finding being areas of decreased lung attenuation. While the HRCT findings are not specific, it is believed that their common features can assist in the diagnosis of BO in BMT recipients.

  7. Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

    DEFF Research Database (Denmark)

    Uhlving, H H; Buchvald, F; Heilmann, C J;

    2012-01-01

    Bronchiolitis obliterans (BO) following allogeneic haematopoietic SCT (HSCT) is a serious complication affecting 1.7-26% of the patients, with a reported mortality rate of 21-100%. It is considered a manifestation of chronic graft-versus-host disease, but our knowledge of aetiology and pathogenesis...

  8. Biomarkers for the prediction of the bronchiolitis obliterans syndrome after lung transplantation

    NARCIS (Netherlands)

    Paantjens, A.W.M.

    2011-01-01

    The main limitation for overall survival after lung transplantation (LTx) is the development of chronic rejection, which is represented by the bronchiolitis obliterans syndrome (BOS). The diagnosis BOS is based on lung function testing, however, it is a surrogate marker. And because BOS is an irreve

  9. Pulmonary Rehabilitation for Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation

    OpenAIRE

    Tran, Jerry; Norder, Emily; Diaz, Phil; Gary S Phillips; Elder, Pat; Devine, Steven M; Wood, Karen L.

    2012-01-01

    Bronchiolitis obliterans syndrome (BOS) is a progressive, insidious lung disease affecting allogeneic hematopoietic stem cell transplant (HSCT) recipients. Unfortunately, there is no standardized approach for treatment of BOS in post HSCT patients. Pulmonary rehabilitation is a standard treatment in emphysema, an irreversible obstructive lung disease secondary to tobacco abuse. The National Emphysema Treatment Trial (NETT) demonstrated improved exercise tolerance, decrease dyspnea, and increa...

  10. Biopsy-verified bronchiolitis obliterans and other noninfectious lung pathologies after allogeneic hematopoietic stem cell transplantation

    DEFF Research Database (Denmark)

    Uhlving, Hilde Hylland; Andersen, Claus B; Christensen, Ib Jarle;

    2015-01-01

    Bronchiolitis obliterans (BO) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Lung biopsy is the gold standard for diagnosis. This study describes the course of BO and assesses the congruity between biopsy-verified BO and a modified version of the National...... Institutes of Health's consensus criteria for BO syndrome (BOS) based exclusively on noninvasive measures. We included 44 patients transplanted between 2000 and 2010 who underwent lung biopsy for suspected BO. Of those, 23 were diagnosed with BO and 21 presented other noninfectious pulmonary pathologies......, such as cryptogenic organizing pneumonia, diffuse alveolar damage, interstitial pneumonia, and nonspecific interstitial fibrosis. Compared with patients with other noninfectious pulmonary pathologies, BO patients had significantly lower values of forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity...

  11. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM"O"P)

    Science.gov (United States)

    Crestani, B; Valeyre, D; Roden, S; Wallaert, B; Dalphin, J C; Cordier, J F

    1998-12-01

    Reports of bronchiolitis obliterans organizing pneumonia (BOOP) occurring in women after radiation therapy for breast cancer have suggested that radiation to the lung could participate in the development of BOOP. We now describe the clinical, radiographic, functional, and bronchoalveolar lavage characteristics of this syndrome in a series of 15 patients reported to the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P) in France. All 15 women (60 +/- 6 yr of age) fulfilled the following inclusion criteria: (1) radiation therapy to the breast within 12 mo, (2) general and/or respiratory symptoms lasting for at least 2 wk, (3) lung infiltrates outside the radiation port, and (4) no specific cause. The patients presented with fever, nonproductive cough, mild dyspnea, and peripheral alveolar opacities on chest radiograph with a characteristic migratory pattern. In five patients, BOOP was found at lung pathologic analysis. In all the patients dramatic improvement was obtained with corticosteroids, but relapses occurred in 12 patients while tapering or after stopping corticosteroids. This report demonstrates that a characteristic BOOP syndrome may occur after radiation therapy to the breast, including tangential radiation to the lung, thus suggesting that radiation therapy may prime the development of BOOP.

  12. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation

    OpenAIRE

    Corris, Paul A; Ryan, Victoria A; Small, Therese; Lordan, James; Fisher, Andrew J.; Meachery, Gerard; Johnson, Gail; Ward, Chris

    2015-01-01

    Background We conducted a placebo-controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. Methods We compared azithromycin (250 mg alternate days, 12 weeks) with placebo. Primary outcome was FEV1 change at 12 weeks. Results 48 patients were randomised; (25 azithromycin, 23 placebo). It was established, post randomisation that two did not have BOS. 46 patients were analysed as intention to treat (ITT) with 33 ‘Completers’. ITT analysis inc...

  13. Rapamycin Blocks Fibrocyte Migration and Attenuates Bronchiolitis Obliterans in a Murine Model

    Science.gov (United States)

    Gillen, Jacob R.; Zhao, Yunge; Harris, David A.; LaPar, Damien J.; Stone, Matthew L.; Fernandez, Lucas G.; Kron, Irving L.; Lau, Christine L.

    2014-01-01

    Background Fibrocytes are integral in the development of fibroproliferative disease. The CXCL12/CXCR4 chemokine axis has been shown to play a central role in fibrocyte migration and the development of bronchiolitis obliterans post lung transplantation. Inhibition of the mTOR (mammalian target of rapamycin) pathway with rapamycin has been shown to decrease expression of both CXCR4 and its receptor agonist, CXCL12. Thus, we hypothesize that rapamycin treatment would decrease fibrocyte trafficking into tracheal allografts and prevent bronchiolitis obliterans. Methods A total alloantigenic mismatch, murine heterotopic tracheal transplant model of bronchiolitis obliterans was used. Animals were either treated with rapamycin or dimethyl sulfoxide (DMSO) for 14 days post tracheal transplant. Fibrocyte levels were assessed via flow cytometry, and allograft neutrophil, CD3+ T-cell, macrophage, and smooth muscle actin levels were assessed via immunohistochemistry. Tracheal luminal obliteration was assessed on hematoxylin and eosin stains. Results Compared to DMSO controls, rapamycin-treated mice showed a significant decrease in fibrocyte levels in tracheal allografts. Fibrocytes levels in recipient’s blood showed a similar pattern, although not statistically significant. Furthermore, animals treated with rapamycin showed a significant decrease in tracheal allograft luminal obliteration compared to controls. Based on immunohistochemistry analyses, populations of α-SMA positive cells, neutrophils, CD3+ T-cells, and macrophages were all decreased in rapamycin-treated allograft versus DMSO controls. Conclusions Rapamycin effectively reduces recruitment of fibrocytes into tracheal allografts and mitigates development of tracheal luminal fibrosis. Further studies are needed to determine the cellular and molecular mechanisms that mediate the protective effect of rapamycin against bronchiolitis obliterans. PMID:23561805

  14. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    OpenAIRE

    Hamidun Bunawan; Siti Noraini Bunawan; Syarul Nataqain Baharum; Normah Mohd Noor

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indon...

  15. Increased Respiratory Disease Mortality at a Microwave Popcorn Production Facility with Worker Risk of Bronchiolitis Obliterans

    OpenAIRE

    Halldin, Cara N; Eva Suarthana; Kathleen B Fedan; Yi-Chun Lo; George Turabelidze; Kathleen Kreiss

    2013-01-01

    BACKGROUND: Bronchiolitis obliterans, an irreversible lung disease, was first associated with inhalation of butter flavorings (diacetyl) in workers at a microwave popcorn company. Excess rates of lung-function abnormalities were related to cumulative diacetyl exposure. Because information on potential excess mortality would support development of permissible exposure limits for diacetyl, we investigated respiratory-associated mortality during 2000-2011 among current and former workers at this...

  16. Ventilation/Perfusion Scintigraphy in Children with Post-Infectious Bronchiolitis Obliterans: A Pilot Study

    OpenAIRE

    Xie, Bo-Qia; Wang, Wei; Zhang, Wen-Qian; Guo, Xin-Hua; Yang, Min-Fu; Wang, Li; He, Zuo-Xiang; Tian, Yue-Qin

    2014-01-01

    Purpose Childhood post-infectious bronchiolitis obliterans (BO) is an infrequent lung disease leading to narrowing and/or complete obliteration of small airways. Ventilation and perfusion (V/Q) scan can provide both regional and global pulmonary information. However, only few retrospective researches investigating post-infectious BO involved V/Q scan, the clinical value of this method is unknown. This preliminary prospective study was aimed to evaluate the correlation of V/Q scan with disease...

  17. 小儿闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    陈强

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,是一种相对少见而严重的慢性阻塞性肺病.其主要临床特点是反复或持续气促、喘息或咳嗽,运动耐力差,肺部有细湿啰音和喘鸣音,对支气管扩张剂无反应[1].

  18. Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?

    Science.gov (United States)

    Madill, Janet; Aghdassi, Ellie; Arendt, Bianca; Hartman-Craven, Brenda; Gutierrez, Carlos; Chow, Chung-Wai; Allard, Johane

    2009-04-01

    Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS. PMID:19298941

  19. 儿童闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎一例并文献复习%Bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review

    Institute of Scientific and Technical Information of China (English)

    韩青; 史彧; 李红霞; 唐文伟; 刘红霞; 赵德育

    2016-01-01

    目的 探讨闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎儿童临床-影像-病理学特点.方法 回顾1例南京医科大学附属南京儿童医院呼吸科2012-2013年收治的肺炎支原体肺炎后合并闭塞性细支气管炎伴机化性肺炎的儿童闭塞性支气管炎患儿临床诊治情况、影像学表现、组织病理学所见,并复习相关文献.结果 10岁女童,反复咳嗽、咯黄脓痰、不规则发热1个月,左下肺呼吸音低并有管状呼吸音;肺部影像示左下肺支气管扩张、扭曲,远端肺不张.纤维支气管镜见支气管黏膜滤泡增生,左下支气管亚段以下闭塞、痰栓.肺组织切面灰红、灰黄,局灶肉质变,管腔内少量黄色分泌物;镜下见肺组织纤维结缔组织增生、见泡沫细胞及Masson小体.肺炎支原体抗体IgM>1∶160.经红霉素等抗感染,纤维支气管镜灌洗后一度改善,但因病情反复最终行左肺切除,术后恢复良好.检索1990年1月-2016年1月CNKI中文数据库及PubMed,以“闭塞性支气管炎”与“闭塞性细支气管炎伴机化性肺炎”同时检索,没有检索到国内外任何文献.结论 闭塞性支气管炎合并闭塞性细支气管炎伴机化性肺炎患儿表现为发热及呼吸道症状迁延不愈,肺部呼吸音低、管状呼吸音;肺炎支原体抗体阳性.影像学表现支气管扩张、远端肺不张.病理学检查可见肺纤维结缔组织增生、Masson小体.经肺叶切除病情好转.%Objective To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP).Method The clinical manifestations,characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed.Result A 10-year-old girl complained of recurrent paroxysmal cough and episodes of

  20. Acute cellular rejection is a risk factor for bronchiolitis obliterans syndrome independent of post-transplant baseline FEV1

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.;

    2009-01-01

    BACKGROUND: Post-transplant baseline forced expiratory volume in 1 second (FEV(1)) constitutes a systematic bias in analyses of bronchiolitis obliterans syndrome (BOS). This retrospective study evaluates risk factors for BOS adjusting for the confounding of post-transplant baseline FEV(1). METHODS...

  1. Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.

    Science.gov (United States)

    Ghandourah, Hasan; Bhandal, Samarjeet; Brundler, Marie-Anne; Noseworthy, Mary

    2016-01-01

    A 14-year-old girl who was known to have a seizure disorder and on lamotrigine treatment was admitted to the hospital, with a history of rash, fever and cough. Her condition deteriorated with clinical features suggestive of anticonvulsant hypersensitivity syndrome (ACHS) complicated with bronchiolitis obliterans organising pneumonia (BOOP). Her chest CT showed multifocal parenchymal opacities and lung biopsy was typical for BOOP. Initially, the lamotrigine was discontinued since the onset of the rash, then she was treated for pneumonia with antibiotics, which may have delayed the diagnosis. Eventually, BOOP was considered and she was treated with a high dose of corticosteroid. She improved clinically and her repeated chest CT showed a marked resolution of the lesions. This case illustrates the possible occurrence of BOOP as a complication of ACHS secondary to lamotrigine treatment. PMID:26825933

  2. Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans.

    Directory of Open Access Journals (Sweden)

    Cara N Halldin

    Full Text Available BACKGROUND: Bronchiolitis obliterans, an irreversible lung disease, was first associated with inhalation of butter flavorings (diacetyl in workers at a microwave popcorn company. Excess rates of lung-function abnormalities were related to cumulative diacetyl exposure. Because information on potential excess mortality would support development of permissible exposure limits for diacetyl, we investigated respiratory-associated mortality during 2000-2011 among current and former workers at this company who had exposure to flavorings and participated in cross-sectional surveys conducted between 2000-2003. METHODS: We ascertained workers' vital status through a Social Security Administration search. Causes of death were abstracted from death certificates. Because bronchiolitis obliterans is not coded in the International Classification of Disease 10(th revision (ICD-10, we identified respiratory mortality decedents with ICD-10 codes J40-J44 which encompass bronchitis (J40, simple and mucopurulent chronic bronchitis (J41, unspecified chronic bronchitis (J42, emphysema (J43, and other chronic obstructive pulmonary disease (COPD (J44. We calculated expected number of deaths and standardized mortality ratios (SMRs with 95% confidence intervals (CI to determine if workers exposed to diacetyl experienced greater respiratory mortality than expected. RESULTS: We identified 15 deaths among 511 workers. Based on U.S. population estimates, 17.39 deaths were expected among these workers (SMR = 0.86; CI:0.48-1.42. Causes of death were available for 14 decedents. Four deaths among production and flavor mixing workers were documented to have a multiple cause of 'other COPD' (J44, while 0.98 'other COPD'-associated deaths were expected (SMR = 4.10; CI:1.12-10.49. Three of the 4 'other COPD'-associated deaths occurred among former workers and workers employed before the company implemented interventions reducing diacetyl exposure in 2001. CONCLUSION: Workers

  3. Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study

    Science.gov (United States)

    Politano, Gianfranco; Inghilleri, Simona; Morbini, Patrizia; Calabrese, Fiorella; Benso, Alfredo; Savino, Alessandro; Cova, Emanuela; Zampieri, Davide; Meloni, Federica

    2016-01-01

    The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the study of BOS. The analysis considered the full set of miRNAs annotated in miRBase (version 21), and applied a sequence of filtering approaches and statistical analyses to reduce this set and to score the candidate miRNAs according to their potential involvement in BOS development. Dysregulation of two of the selected candidate miRNAs–miR-34a and miR-21 –was clearly shown in in-situ hybridization (ISH) on five explanted human BOS lungs and on a rat model of acute and chronic lung rejection, thus definitely identifying miR-34a and miR-21 as pathogenic factors in BOS and confirming the effectiveness of the computational pipeline. PMID:27564214

  4. Oxygen-sensitive {sup 3}He-MRI in bronchiolitis obliterans after lung transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Gast, Klaus K. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, Mainz (Germany); Biedermann, Alexander [Klinikum der Johannes Gutenberg-Universitaet, 3. Medizinische Klinik, Pulmonologie, Mainz (Germany); Herweling, Annette [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Anaesthesiologie, Mainz (Germany); Schreiber, Wolfgang G. [Klinikum der Johannes Gutenberg-Universitaet, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie, MR-Physik, Mainz (Germany); Schmiedeskamp, Joerg [Max-Planck-Institut fuer Polymerforschung, Mainz (Germany); Mayer, Eckhard [Klinikum der Johannes Gutenberg-Universitaet, Klinik fuer Herz-, Thorax- und Gefaesschirurgie, Mainz (Germany); Heussel, Claus P. [Abteilung fuer Radiologie, Thoraxklinik Heidelberg, Heidelberg (Germany); Markstaller, Klaus; Eberle, Balthasar [Inselspital/Universitaetsspital, Klinik fuer Anaesthesiologie, Bern (Switzerland); Kauczor, Hans-Ulrich [Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany)

    2008-03-15

    Oxygen-sensitive {sup 3}He-MRI was studied for the detection of differences in intrapulmonary oxygen partial pressure (pO{sub 2}) between patients with normal lung transplants and those with bronchiolitis obliterans syndrome (BOS). Using software developed in-house, oxygen-sensitive {sup 3}He-MRI datasets from patients with normal lung grafts (n = 8) and with BOS (n = 6) were evaluated quantitatively. Datasets were acquired on a 1.5-T system using a spoiled gradient echo pulse sequence. Underlying diseases were pulmonary emphysema (n = 10 datasets) and fibrosis (n = 4). BOS status was verified by pulmonary function tests. Additionally, {sup 3}He-MRI was assessed blindedly for ventilation defects. Median intrapulmonary pO{sub 2} in patients with normal lung grafts was 146 mbar compared with 108 mbar in patients with BOS. Homogeneity of pO2 distribution was greater in normal grafts (standard deviation pO2 34 versus 43 mbar). Median oxygen decrease rate during breath hold was higher in unaffected patients (-1.75 mbar/s versus -0.38 mbar/s). Normal grafts showed fewer ventilation defects (5% versus 28%, medians). Oxygen-sensitive {sup 3}He-MRI appears capable of demonstrating differences of intrapulmonary pO2 between normal lung grafts and grafts affected by BOS. Oxygen-sensitive {sup 3}He-MRI may add helpful regional information to other diagnostic techniques for the assessment and follow-up of lung transplant recipients. (orig.)

  5. Bronchiolitis obliterans following exposure to sulfur mustard: chest high resolution computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Ghanei, Mostafa E-mail: m.ghanei@bmsu.ac.ir; Mokhtari, Majid; Mohammad, Mehdi Mir; Aslani, Jafar

    2004-11-01

    Background: Pulmonary complications are known to occur in over half of the patients exposed to sulfur mustard (SM). Chemical weapons of mass destruction (WMD) including SM were used by Iraq during Iran-Iraq war between 1983 and 1989. We undertook this study to evaluate the chest high resolution computerized tomography (HRCT) as a diagnostic tool in patients with documented exposure to SM and chronic respiratory symptoms. Method: The medical records of 155 patients exposed to SM during Iran-Iraq war and suffered respiratory complications were reviewed. Chest HRCTs of these patients were examined. Ten healthy controls with no history of exposure to HD were matched for age, gender, and chest HRCT protocol applied. Results: Fifty chest HRCTs of these patients were randomly selected for this study. The most frequent findings were; air trapping 38 (76%), bronchiectasis 37 (74%), mosaic parenchymal attenuation (MPA) 36 (72%), irregular and dilated major airways 33 (66%) bronchial wall thickening (BWT) 45 (90%), and interlobular septal wall thickening (SWT) 13 (26%), respectively. Air trapping in one patient (10%) was the only positive finding in the control group. Conclusions: Chest HRCT findings of bronchiectasis, air trapping, MPA, SWT, and BWT were seen in our patients 15 years after exposure to HD. These findings suggest the diagnosis of bronchiolitis obliterans (BO). We did not encounter chest HRCT features consistent with pulmonary fibrosis.

  6. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Science.gov (United States)

    Bunawan, Hamidun; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd.

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr. PMID:26413127

  7. Sauropus androgynus (L. Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology

    Directory of Open Access Journals (Sweden)

    Hamidun Bunawan

    2015-01-01

    Full Text Available Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the “multigreen” or “multivitamin” plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr.

  8. Oxidative stress and nutritional intakes in lung patients with bronchiolitis obliterans syndrome.

    Science.gov (United States)

    Madill, J; Aghdassi, E; Arendt, B M; Gutierrez, C; Singer, L; Chow, C-W; Keshavjee, S; Allard, J P

    2009-11-01

    Survival after lung transplantation is limited by bronchiolitis obliterans syndrome (BOS). Oxidative stress (OxS) can be associated with BOS due to chronic inflammation. The type of fat and antioxidant intakes may also contribute to OxS. Our aim was to compare OxS and nutritional intakes in non-BOS versus various stages of BOS. Fifty-eight lung recipients with versus without BOS were prospectively classified as: non-BOS; BOS Op-1 (mild), and BOS 2-3 (severe). We measured nutritional intake and plasma vitamins A, C, and E. Among a subgroup of 37 patients, OxS was assessed by measuring lipid peroxidation (LPO micromol/L MDA) and oxidized glutathione (GSSG) in bronchoalveolar lavage BAL fluid (BALF). One-way analysis of variance was used to compare groups. Results are reported as mean values +/- standard errors of the mean. There was no significant difference in demographic features on time posttransplant among groups. Although there were comparable cell counts in BALF, severe BOS patients showed significantly higher BALF LPO concentrations when compared with milder stage of BOS or with non-BOS (P = .001, for both). Severe BOS recipients also displayed higher BALF GSSG concentrations compared to milder stage of BOS (P = .001) or non-BOS (P = .007). In conclusion, patients with severe BOS were more oxidatively stressed compared with mild and non-BOS recipients. PMID:19917398

  9. Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology.

    Science.gov (United States)

    Bunawan, Hamidun; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd

    2015-01-01

    Sauropus androgynus L. Merr. is one of the most popular herbs in South Asia, Southeast Asia, and China where it was known as a slimming agent until two outbreaks of pulmonary dysfunction were reported in Taiwan and Japan in 1995 and 2005, respectively. Several studies described that the excessive consumption of Sauropus androgynus could cause drowsiness, constipation, and bronchiolitis obliterans and may lead to respiratory failure. Interestingly, this herb has been used in Malaysia and Indonesia in cooking and is commonly called the "multigreen" or "multivitamin" plant due to its high nutritive value and inexpensive source of dietary protein. The plant is widely used in traditional medicine for wound healing, inducing lactation, relief of urinary disorders, as an antidiabetic cure and also fever reduction. Besides these medicinal uses, the plant can also be used as colouring agent in food. This review will explore and compile the fragmented knowledge available on the botany, ethnobotany, chemical constitutes, pharmacological properties, and toxicological aspects of this plant. This comprehensive review will give readers the fundamental, comprehensive, and current knowledge regarding Sauropus androgynus L. Merr. PMID:26413127

  10. Cell therapy in the treatment of bronchiolitis obliterans in a murine model

    Directory of Open Access Journals (Sweden)

    Julio de Oliveira Espinel

    2015-06-01

    Full Text Available OBJECTIVE: To evaluate the importance of stem cells derived from adipose tissue in reducing graft inflammation in a murine model of allogeneic heterotopic tracheal transplant.METHODS: We performed a heterotopic tracheal allografting in dorsal subcutaneous pouch and systemically injected 5x105 mesenchymal stem cells derived from adipose tissue. The animals were divided into two groups according to the time of sacrifice: T7 and T21. We also carried out histological analysis and digital morphometry.RESULTS: The T7 animals treated with cell therapy had median obstructed graft area of 0 versus 0.54 of controls (p = 0.635. The treated T21 subjects had median obstructed graft area of 0.25 versus 0 in controls (p = 0.041.CONCLUSION: The systemically injected cell therapy in experimental murine model of bronchiolitis obliterans did not reduce the severity of the allograft inflammation in a statistically significant way in seven days; Conversely, in 21 days, it increased the allograft inflammatory process.

  11. Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome

    Science.gov (United States)

    Zhang, Su-Bei; Sun, Xin; Wu, Qi; Wu, Jun-Ping; Chen, Huai-Yong

    2016-01-01

    Background: Bronchiolitis obliterans syndrome (BOS) often develops in transplant patients and results in injury to the respiratory and terminal airway epithelium. Owing to its rising incidence, the pathogenesis of BOS is currently an area of intensive research. Studies have shown that injury to the respiratory epithelium results in dysregulation of epithelial repair. Airway epithelial regeneration is supported by stromal cells, including fibroblasts. This study aimed to investigate whether the supportive role of lung fibroblasts is altered in BOS. Methods: Suspensions of lung cells were prepared by enzyme digestion. Lung progenitor cells (LPCs) were separated by fluorescence-activated cell sorting. Lung fibroblasts from patients with BOS or healthy controls were mixed with sorted mouse LPCs to compare the colony-forming efficiency of LPCs by counting the number of colonies with a diameter of ≥50 μm in each culture. Statistical analyses were performed using the SPSS 17.0 software (SPSS Inc., USA). The paired Student's t-test was used to test for statistical significance. Results: LPCs were isolated with the surface phenotype of CD31- CD34- CD45- EpCAM+ Sca-1+. The colony-forming efficiency of LPCs was significantly reduced when co-cultured with fibroblasts isolated from patients with BOS. The addition of SB431542 increased the colony-forming efficiency of LPCs to 1.8%; however, it was still significantly less than that in co-culture with healthy control fibroblasts (P < 0.05). Conclusion: The epithelial-supportive capacity of fibroblasts is impaired in the development of BOS and suggest that inefficient repair of airway epithelium could contribute to persistent airway inflammation in BOS. PMID:27569228

  12. Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    MO Xiao-dong; XU Lan-ping; LIU Dai-hong; ZHANG Xiao-hui; CHEN Huan; CHEN Yu-hong; HAN Wei

    2013-01-01

    Background The occurrence of bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (alIo-HSCT) is rare but severe.We examine the role of pre-HSCT chemotherapeutic exposure,pre-HSCT comorbidities,and transplant-related complications in the development of BOS after allo-HSCT.Methods A nested case-control study was designed.Cases with BOS and controls matched for the year of alIo-HSCT and length of the follow-up were identified from a cohort of 1646 patients who underwent alIo-HSCT for treatment of hematologic malignancies between 2006 and 2011.Antithymocyte globulin was used in the partial matched related and unrelated matched donor HSCT,or patients with severe aplastic anemia.Results Thirty-six patients suffered from BOS; the mean age at the time of presentation was (32.7±12.4) years,and the mean time to presentation was (474±350) days post-HSCT.A pre-HSCT cyclophosphamide dose of >3.2 g/m2 (OR=8.74,P=0.025),chronic graft-versus-host disease (moderate to severe) (OR=12.02,P=0.000),and conditioning regimens without antithymocyte globulin (OR=2.79,P=0.031) were independently associated with BOS.Conclusions We found that higher pre-HSCT cyclophosphamide exposure,a conditioning regimen without antithymocyte globulin,and moderate to severe chronic graft-versus-host disease are significantly and independently associated with BOS.Based on these results,we can identify patients who are at a higher risk of developing BOS after alIo-HSCT,select a more appropriate therapeutic strategy,and improve the outcome of HSCT recipients.

  13. The number of FoxP3+ cells in transbronchial lung allograft biopsies does not predict bronchiolitis obliterans syndrome within the first five years after transplantation

    DEFF Research Database (Denmark)

    Krustrup, Dorrit; Iversen, Martin; Martinussen, Torben;

    2015-01-01

    Background: An important limitation to the success of lung transplantation is the development of bronchiolitis obliterans syndrome (BOS). It has been hypothesized that regulatory T lymphocytes (Tregs) are related to the risk of BOS. We aim to evaluate whether the number of forkhead box P3 (FoxP3...

  14. Bronchiolitis obliterans organising pneumonia. A report of 11 cases and a review of the literature.

    Science.gov (United States)

    Lamont, J; Verbeken, E; Verschakelen, J; Demedts, M

    1998-10-01

    The clinical syndrome "Bronchiolitis Obliterans Organising Pneumonia" (BOOP) has to be considered in patients with a flu-like illness since some weeks, fine crackles, and on chest X-ray bilateral patchy infiltrates. There is no response to antibiotics. BOOP is essentially idiopathic, but associations to other conditions exist. Lung function is often restrictive; biochemistry is not pathognomonic. BAL shows a mixed cellular pattern. The gold standard for pathologic diagnosis is open or thoracoscopic lung biopsy. However, a BOOP pattern or reaction is often seen on histologic specimens without the clinical-radiologic features of the BOOP-entity. Therapy consists of corticosteroids, which have to be prescribed for a long time at a rather high dose. Recurrence is frequent, but prognosis is good. Evolution to respiratory insufficiency and death is rare and may occur in rapidly progressive BOOP. This study reports on 11 cases (6 males/5 females) of clinical-pathological BOOP-syndrome (mean age 58 yrs, range 17-73 yrs), with an unexpectedly high mortality rate of 36% (4 cases). The disease was idiopathic in 7, and was associated with intake of amiodarone (in 1), with past Mycoplasma pneumonia (in 1) and with connective tissue disease (in 2). There was a history of a flu-like syndrome, cough and dyspnea of a mean duration of 4 months (range 1 week to 8 months). Lung function was mostly restrictive or/and obstructive with a diffusing capacity ranging between 47 and 95% predicted; there was hypoxia in about half of the patients. Chest X-ray and computed tomography (CT) scan showed a patchy consolidation with linear opacities (unilateral in 4 patients, bilateral in 5) and/or a ground glass pattern (in 4 patients), and a focal pseudo-tumoral lesion (in 1). Bronchoalveolar lavage showed a variable pattern of mixed, or eosinophilic or neutrophilic alveolitis. Histologic diagnosis was based on open lung biopsy (in 3), on thoracoscopic biopsy (in 2), on transbronchial biopsy (in 2

  15. Improving survival outcomes in lung transplant recipients through early detection of bronchiolitis obliterans: Daily home spirometry versus standard pulmonary function testing

    OpenAIRE

    Robson, Kevin S; West, Andrew J.

    2014-01-01

    BACKGROUND: Long-term lung transplant success is limited by bronchiolitis obliterans syndrome (BOS), a form of chronic allograft rejection that manifests in the majority of patients by five years post-transplant. Frequent monitoring of pulmonary function measurements through the use of daily home spirometry may have the capability to detect the onset of BOS sooner than standard pulmonary function testing. Early detection of BOS would confer a treatment advantage that may improve survival outc...

  16. 儿童感染后闭塞性细支气管炎研究进展%Post-infectious bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    吴小英

    2012-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种由严重小气道炎症损伤引起的少见的慢性气道阻塞性肺疾病.BO常见病因有感染、心肺或骨髓移植、吸入有毒物质、胃食管反流、结缔组织病及药物性等.儿童以感染后BO(post-infectious bronchiolitis obliterans,PIBO)最常见.文章综述PIBO研究进展.%Bronchiolitis obliterans (BO) is a rare form of chronic obstructive lung disease that follows a severe inflammatory insult to the small airways. The common etiologies of BO include infection, transplantations of the lung, the heart or the bone-marrow, toxic inhalation, gastroesophageal reflux, connective tissue disorders, drugs and so on. In children, post-infectious BO (PIBO) is the most common form. This article reviews the recent progress of PIBO in children.

  17. Managing bronchiolitis obliterans syndrome (BOS) and chronic lung allograft dysfunction (CLAD) in children: what does the future hold?

    Science.gov (United States)

    Snell, Gregory I; Paraskeva, Miranda; Westall, Glen P

    2013-08-01

    The success of pediatric lung transplantation continues to be limited by long-term graft dysfunction. Historically this has been characterized as an obstructive spirometric defect in the form of the bronchiolitis obliterans syndrome (BOS). It is recognized, however, that this does not reflect many of the other acknowledged etiologies of chronic lung dysfunction-noting it is the sum of the parts that contribute to respiratory morbidity and mortality after transplant. The term chronic lung allograft dysfunction (CLAD) has been coined to reflect these other entities and, in particular, a group of relatively recently described lung disorders called the restrictive allograft syndrome (RAS). RAS is characterized by a restrictive spirometric defect. Although these entities have not yet been studied in a pediatric setting their association with poor compliance, antibody-mediated rejection (AMR), and post-infectious lung damage (particularly viral) warrants attention by pediatric lung transplant teams. Current therapy for the BOS subset of CLAD is otherwise limited to changing immunosuppressants and avoiding excessive infectious risk by avoiding over-immunosuppression. Long-term macrolide therapy in lung transplantation is not of proven efficacy. Reviewing previous BOS studies to explore restrictive spirometric cases and joint projects via groups like the International Pediatric Lung Transplant Collaborative will be the way forward to solve this pressing problem.

  18. Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0p in Chronic Graft-versus-Host Disease of the Lung

    Science.gov (United States)

    Abedin, Sameem; Yanik, Gregory A.; Braun, Thomas; Pawarode, Attaphol; Magenau, John; Goldstein, Steven C.; Levine, John E.; Kitko, Carrie L.; Couriel, Daniel R.

    2016-01-01

    Bronchiolitis obliterans syndrome (BOS) is a significant post-transplant complication with low survival. BOS stage 0p (BOS 0p) is a parameter detected on pulmonary function tests (PFTs) after lung transplantation to identify patients at risk to develop BOS. We performed a retrospective study on 442 patients who underwent allogeneic stem cell transplant from 2007 to 2011 to evaluate whether development of BOS 0p is a risk factor in this population for BOS. Patients who met criteria for BOS 0p were significantly more likely to develop BOS (hazard ratio [HR], 3.22; P HR, 2.48; P =.001) and chronic graft-versus-host disease (GVHD) outside the lung post-transplant (HR, 23; P < .001). Finally, BOS 0p criteria were adequately sensitive in predicting BOS (85%), with a high negative predictive value (98%). Our findings suggest a routine PFT screening strategy with the intent of detecting BOS 0p, especially among patients with prior lung disease and who developed chronic GVHD, could suitably identify an at-risk population for the development of BOS. PMID:25687798

  19. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

    International Nuclear Information System (INIS)

    To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. (orig.)

  20. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Gi [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Ajou University Medical Center, Department of Radiology, Ajou University School of Medicine, Suwon (Korea, Republic of); Shin, Hyun Joo; Kim, Myung-Joon; Lee, Mi-Jung [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Kim, Yoon Hee; Sohn, Myung Hyun; Kim, Kyung Won [Yonsei University College of Medicine, Department of Pediatrics and Institute of Allergy, Severance Children' s Hospital, Seoul (Korea, Republic of); Lyu, Chuhl Joo [Yonsei University College of Medicine, Department of Pediatric Hematology and Oncology, Severance Children' s Hospital, Seoul (Korea, Republic of)

    2015-10-15

    To suggest a simple method that can quantify air trapping from chest CT in children with graft-versus-host disease (GVHD)-related bronchiolitis obliterans (BO). This institutional review board-approved retrospective study included eight GVHD-related BO patients (age, 6 - 17 years) who underwent both 31 CTs of variable settings and pulmonary function tests (PFT). The attenuation values of lung parenchyma in normal (An) and air trapping (Aa) areas were obtained. Individualized threshold [(An + Aa)/2] and fixed threshold of -950 HU were set for air trapping quantification. Spearman correlation analysis and generalized linear mixed models were used for statistical analysis. The mean value of individualized threshold was -830.2 ± 48.3 HU. The mean air trapping lung volume percentage with individualized threshold and -950 HU were 45.4 ± 18.9 % and 1.4 ± 1.9 %, respectively. The air trapping lung volume percentage with individualized threshold showed a significant negative correlation with the PFT of FEV1/FVC% in all data (γ = -0.795, P <.001) and in the correction of repetition (γ = -0.837, P =.010). We suggest a simple and individualized threshold attenuation setting method for air trapping quantification insusceptible to CT imaging protocols or respiratory phase control in children with GVHD-related BO. (orig.)

  1. Proteomic Characterization Reveals That MMP-3 Correlates With Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Cell and Lung Transplantation.

    Science.gov (United States)

    Liu, X; Yue, Z; Yu, J; Daguindau, E; Kushekhar, K; Zhang, Q; Ogata, Y; Gafken, P R; Inamoto, Y; Gracon, A; Wilkes, D S; Hansen, J A; Lee, S J; Chen, J Y; Paczesny, S

    2016-08-01

    Improved diagnostic methods are needed for bronchiolitis obliterans syndrome (BOS), a serious complication after allogeneic hematopoietic cell transplantation (HCT) and lung transplantation. For protein candidate discovery, we compared plasma pools from HCT transplantation recipients with BOS at onset (n = 12), pulmonary infection (n = 16), chronic graft-versus-host disease without pulmonary involvement (n = 15) and no chronic complications after HCT (n = 15). Pools were labeled with different tags (isobaric tags for relative and absolute quantification), and two software tools identified differentially expressed proteins (≥1.5-fold change). Candidate proteins were further selected using a six-step computational biology approach. The diagnostic value of the lead candidate, matrix metalloproteinase 3 (MMP3), was evaluated by enzyme-linked immunosorbent assay in plasma of a verification cohort (n = 112) with and without BOS following HCT (n = 76) or lung transplantation (n = 36). MMP3 plasma concentrations differed significantly between patients with and without BOS (area under the receiver operating characteristic curve 0.77). Consequently, MMP3 represents a potential noninvasive blood test for diagnosis of BOS. PMID:26887344

  2. Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells.

    Directory of Open Access Journals (Sweden)

    Aric L Gregson

    Full Text Available Bronchiolitis obliterans syndrome (BOS is the major obstacle to long-term survival after lung transplantation, yet markers for early detection and intervention are currently lacking. Given the role of regulatory T cells (Treg in modulation of immunity, we hypothesized that frequencies of Treg in bronchoalveolar lavage fluid (BALF after lung transplantation would predict subsequent development of BOS. Seventy BALF specimens obtained from 47 lung transplant recipients were analyzed for Treg lymphocyte subsets by flow cytometry, in parallel with ELISA measurements of chemokines. Allograft biopsy tissue was stained for chemokines of interest. Treg were essentially all CD45RA(-, and total Treg frequency did not correlate to BOS outcome. The majority of Treg were CCR4(+ and CD103(- and neither of these subsets correlated to risk for BOS. In contrast, higher percentages of CCR7(+ Treg correlated to reduced risk of BOS. Additionally, the CCR7 ligand CCL21 correlated with CCR7(+ Treg frequency and inversely with BOS. Higher frequencies of CCR7(+ CD3(+CD4(+CD25(hiFoxp3(+CD45RA(- lymphocytes in lung allografts is associated with protection against subsequent development of BOS, suggesting that this subset of putative Treg may down-modulate alloimmunity. CCL21 may be pivotal for the recruitment of this distinct subset to the lung allograft and thereby decrease the risk for chronic rejection.

  3. Bronchial wall measurements in patients after lung transplantation: evaluation of the diagnostic value for the diagnosis of bronchiolitis obliterans syndrome.

    Directory of Open Access Journals (Sweden)

    Sabine Dettmer

    Full Text Available OBJECTIVES: To prospectively evaluate quantitative airway wall measurements of thin-section CT for the diagnosis of Bronchiolitis Obliterans Syndrome (BOS following lung transplantation. MATERIALS AND METHODS: In 141 CT examinations, bronchial wall thickness (WT, the wall area percentage (WA% calculated as the ratio of the bronchial wall area and the total area (sum of bronchial wall area and bronchial lumen area and the difference of the WT on inspiration and expiration (WTdiff were automatically measured in different bronchial generations. The measurements were correlated with the lung function parameters. WT and WA% in CT examinations of patients with (n = 25 and without (n = 116 BOS, were compared using the unpaired t-test and univariate analysis of variance, while also considering the differing lung volumes. RESULTS: Measurements could be performed in 2,978 bronchial generations. WT, WA%, and WTdiff did not correlate with the lung function parameters (r<0.5. The WA% on inspiration was significantly greater in patients with BOS than in patients without BOS, even when considering the dependency of the lung volume on the measurements. WT on inspiration and expiration and WA% on expiration did not show significant differences between the groups. CONCLUSION: WA% on inspiration was significantly greater in patients with than in those without BOS. However, WA% measurements were significantly dependent on lung volume and showed a high variability, thus not allowing the sole use of bronchial wall measurements to differentiate patients with from those without BOS.

  4. ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

    Directory of Open Access Journals (Sweden)

    V. Z. Krivitskaya

    2015-01-01

    Full Text Available Exacerbation of bronchial asthma (BA and common deterioration of health during chronic bronchiolitis obliterans (ChBO are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50% in patients with BA. Influenza A(H1N1pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1pdm09 (63% of seroconversions. There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1 pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity. 

  5. Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation.

    Science.gov (United States)

    Williams, Kirsten M; Cheng, Guang-Shing; Pusic, Iskra; Jagasia, Madan; Burns, Linda; Ho, Vincent T; Pidala, Joseph; Palmer, Jeanne; Johnston, Laura; Mayer, Sebastian; Chien, Jason W; Jacobsohn, David A; Pavletic, Steven Z; Martin, Paul J; Storer, Barry E; Inamoto, Yoshihiro; Chai, Xiaoyu; Flowers, Mary E D; Lee, Stephanie J

    2016-04-01

    Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (HCT) is associated with high mortality. We hypothesized that inhaled fluticasone, azithromycin, and montelukast (FAM) with a brief steroid pulse could avert progression of new-onset BOS. We tested this in a phase II, single-arm, open-label, multicenter study (NCT01307462). Thirty-six patients were enrolled within 6 months of BOS diagnosis. The primary endpoint was treatment failure, defined as 10% or greater forced expiratory volume in 1 second decline at 3 months. At 3 months, 6% (2 of 36, 95% confidence interval, 1% to 19%) had treatment failure (versus 40% in historical controls, P < .001). FAM was well tolerated. Steroid dose was reduced by 50% or more at 3 months in 48% of patients who could be evaluated (n = 27). Patient-reported outcomes at 3 months were statistically significantly improved for Short-Form 36 social functioning score and mental component score, Functional Assessment of Cancer Therapies emotional well-being, and Lee symptom scores in lung, skin, mouth, and the overall summary score compared to enrollment (n = 24). At 6 months, 36% had treatment failure (95% confidence interval, 21% to 54%, n = 13 of 36, with 6 documented failures, 7 missing pulmonary function tests). Overall survival was 97% (95% confidence interval, 84% to 100%) at 6 months. These data suggest that FAM was well tolerated and that treatment with FAM and steroid pulse may halt pulmonary decline in new-onset BOS in the majority of patients and permit reductions in systemic steroid exposure, which collectively may improve quality of life. However, additional treatments are needed for progressive BOS despite FAM. PMID:26475726

  6. A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation

    Directory of Open Access Journals (Sweden)

    Kastelijn Elisabeth A

    2011-11-01

    Full Text Available Abstract Background Caveolin 1 (Cav-1 is the primary structural component of cell membrane invaginations called 'caveolae'. Expression of Cav-1 is implicated in the pathogenesis of pulmonary fibrosis. Genetic polymorphisms in the CAV1 gene influence the function of Cav-1 in malignancies and associate with renal allograft fibrosis. Chronic allograft rejection after lung transplantation, called 'bronchiolitis obliterans syndrome' (BOS, is also characterised by the development of fibrosis. In this study, we investigated whether CAV1 genotypes associate with BOS and whether Cav-1 serum levels are influenced by the CAV1 genotype and can be used as a biomarker to predict the development of BOS. Methods Twenty lung transplant recipients with BOS (BOSpos, ninety without BOS (BOSneg and four hundred twenty-two healthy individuals donated DNA samples. Four SNPs in CAV1 were genotyped. Serial Cav-1 serum levels were measured in a matched cohort of 10 BOSpos patients and 10 BOSneg patients. Furthermore, single-time point Cav-1 serum levels were measured in 33 unmatched BOSneg patients and 60 healthy controls. Results Homozygosity of the minor allele of rs3807989 was associated with an increased risk for BOS (odds ratio: 6.13; P = 0.0013. The median Cav-1 serum level was significantly higher in the BOSpos patients than in the matched BOSneg patients (P = 0.026. Longitudinal analysis did not show changes in Cav-1 serum levels over time in both groups. The median Cav-1 serum level in the group of 43 BOSneg patients was lower than that in the healthy control group (P = 0.046. In lung transplant recipients, homozygosity of the minor allele of rs3807989 and rs3807994 was associated with increased Cav-1 serum levels. Conclusion In lung transplant recipients, the CAV1 SNP rs3807989 was associated with the development of BOS and Cav-1 serum levels were influenced by the CAV1 genotype.

  7. 儿童闭塞性细支气管炎%Bronchiolitis obliterans in children

    Institute of Scientific and Technical Information of China (English)

    王维; 申昆玲

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是1901年德国病理学家Lange首次报道并命名的。从病理学角度,BO被定义为两种类型的支气管损伤:狭窄性细支气管炎和增殖性细支气管炎。从临床意义上讲,BO是一种与小气道炎症损伤相关的慢性气流阻塞综合征。各种因素导致的细支气管上皮细胞和上皮下结构的损伤和炎症,及机体对以上损伤和炎症的不正当修复是BO的发病原因。

  8. Bronchiolitis obliterans organizing pneumonia during low-dose amiodarone therapy

    NARCIS (Netherlands)

    Jessurun, GAJ; Hoogenberg, K; Crijns, HJGM

    1997-01-01

    Two cases of amiodarone-induced pulmonary toxicity during a relatively short period of low-dose amiodarone treatment are reported. The toxicity risk of amiodarone is determined by cumulative factors in individual patients.

  9. Bronchiolitis: adopting a unifying definition and a comprehensive etiological classification.

    Science.gov (United States)

    Papiris, Spyros A; Malagari, Katerina; Manali, Effrosyni D; Kolilekas, Likurgos; Triantafillidou, Christina; Baou, Katerina; Rontogianni, Dimitra; Bouros, Demosthenes; Kagouridis, Konstantinos

    2013-06-01

    Bronchiolitis is an inflammatory and potentially fibrosing condition affecting mainly the intralobular conducting and transitional small airways. Secondary bronchiolitis participates in disease process of the airways and/or the surrounding lobular structures in the setting of several already defined clinical entities, mostly of known etiology, and occurs commonly. Primary or idiopathic bronchiolitis dominates and characterizes distinct clinical entities, all of unknown etiology, and occurs rarely. Secondary bronchiolitis regards infections, hypersensitivity disorders, the whole spectrum of smoking-related disorders, toxic fumes and gas inhalation, chronic aspiration, particle inhalation, drug-induced bronchiolar toxicities, sarcoidosis and neoplasms. Idiopathic or primary bronchiolitis defines clinicopathologic entities sufficiently different to be designated as separate disease entities and include cryptogenic constrictive bronchiolitis, diffuse panbronchiolitis, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, neuroendocrine hyperplasia in infants, bronchiolitis obliterans syndrome in lung and allogeneic hematopoietic cell transplantation, connective tissue disorders, inflammatory bowel disease and bronchiolitis obliterans organizing pneumonia. Most of the above are pathological descriptions used as clinical diagnosis. Acute bronchiolitis, though potentially life threatening, usually regresses. Any etiology chronic bronchiolitis contributes to morbidity and/or mortality if it persists and/or progresses to diffuse airway narrowing and distortion or complete obliteration. Bronchiolitis in specific settings leads to bronchiolectasis, resulting in bronchiectasis.

  10. Associação de bronquiolite obliterante pós-infecciosa e hemossiderose pulmonar na infância Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood

    Directory of Open Access Journals (Sweden)

    Leonardo Araújo Pinto

    2006-12-01

    Full Text Available Descreve-se uma apresentação rara de bronquiolite obliterante associada a hemossiderose pulmonar, em paciente de nove anos com sintomas respiratórios persistentes iniciados após episódio de bronquiolite aguda grave aos sete meses. Após o episódio agudo, apresentou sintomas respiratórios persistentes, piorando significativamente aos sete anos, quando começou a apresentar dificuldade respiratória em pequenos esforços. A tomografia computadorizada de tórax demonstrou achados compatíveis com bronquiolite obliterante. A biópsia pulmonar a céu aberto demonstrou numerosos macrófagos corados com hemossiderina, além dos achados compatíveis com bronquiolite obliterante. O diagnóstico de hemossiderose pulmonar pode estar ocasionalmente associado a bronquiolite obliterante em crianças com seqüela pós-viral grave.In the present report, we describe an unusual presentation of post-infectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in a nine-year-old boy with persistent respiratory symptoms subsequent to an episode of acute bronchiolitis occurring at the age of seven months. After the episode, the persistent respiratory symptoms worsened significantly, and, by the age of seven, the patient began to have difficulty breathing after minimal exertion. Computed tomography of the chest presented findings consistent with bronchiolitis obliterans. Open lung biopsy revealed numerous hemosiderin-laden macrophages, as well as other findings consistent with bronchiolitis obliterans. Pulmonary hemosiderosis can occasionally be accompanied by bronchiolitis obliterans in children with severe sequelae after an episode of viral infection.

  11. 肺移植后OB动物模型的研究进展%Progress on animal model of bronchiolitis obliterans after lung transplantation

    Institute of Scientific and Technical Information of China (English)

    康乐

    2014-01-01

    肺移植(lung transplantation,LT)已成为治疗终末期肺疾病患者生命的一个重要手段.细支气管闭塞综合征(bronchiolitis obliterans syndrome,BOS)作为LT术后的一种并发症广泛存在,其特征性病理表现为闭塞性细支气管炎(obliterative bronchiolitis,OB):细支气管周围有淋巴细胞浸润,最终导致纤维瘢痕的形成和细支气管闭塞.理想的动物模型有助于研究的进一步开展.目前,研究肺移植缺少一种理想的动物模型.了解肺移植后闭塞性细支气管炎的发病机制,有助于改善肺移植病人的生活质量,延长肺移植后患者生存率.本研究23将就肺移植后的闭塞性细支气管炎模型做一综述.

  12. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    ABSTRACT Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting ß2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. PMID:27383939

  13. Serum Krebs Von Den Lungen-6 as a Biomarker for Early Detection of Bronchiolitis Obliterans Syndrome in Children Undergoing Allogeneic Stem Cell Transplantation.

    Science.gov (United States)

    Gassas, Adam; Schechter, Tal; Krueger, Joerg; Craig-Barnes, Hayley; Sung, Lillian; Ali, Muhammad; Dell, Sharon; Egeler, R Maarten; Zaidman, Irina; Palaniyar, Nades

    2015-08-01

    Bronchiolitis obliterans syndrome (BOS) is a devastating complication after allogeneic stem cell transplantation (allo-SCT). Early identification of high-risk patients is pivotal for success. Lung proteins, KL-6, CCSP, SP-A, and SP-D, measured in the serum may identify high-risk patients for BOS earlier than pulmonary function tests (PFTs) can identify changes or clinical symptoms. Lung proteins were measured in patients' serum at baseline and at 1, 3, 6, 9, 12, 18, and 24 months after transplantation along with history, clinical examination, and PFTs. Serum levels of lung proteins were also measured in healthy control subjects. The primary endpoint was the development of BOS confirmed by pathological biopsy or National Institutes of Health criteria. Between September 2009 and September 2011, 39 patients were enrolled. Six children developed BOS at a median time of 200 days (range, 94 to 282). KL-6 levels were low in control subjects, at a median of .1 U/mL (range, .1 to 1.5). Pre-SCT and 1-month KL-6 levels were significantly higher in surviving patients who developed BOS (n = 6) versus those who did not (n = 18) (pre-SCT: mean, 32.6 U/mL [IQR, 9.7 to 89.3] versus 5.8 U/mL [IQR, 2.1 to 12.6], P = .03; at 1 month: mean, 52.5 U/mL [IQR, 20.2 to 121.3] versus 11.4 U/mL [IQR, 5.7 to 36.0], P = .04). Three- and 6-month KL-6 levels continued to be higher in BOS group but were not statistically significant. CCSP, SP-A, and SP-D were not predictive. KL-6 measured in the serum of children receiving allo-SCT may identify patients at high risk for the development of BOS. These patients will benefit from intensive surveillance protocol and early therapy before irreversible lung damage. PMID:25963919

  14. Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans.

    Science.gov (United States)

    Calabrese, Cecilia; Corcione, Nadia; Rea, Gaetano; Stefanelli, Francesco; Meoli, Ilernando; Vatrella, Alessandro

    2016-01-01

    Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity. Here, we report the case of a relatively young man diagnosed with PIBO and followed for three years. After short- and long-term therapy with an inhaled corticosteroid/long-acting 2 agonist combination, together with an inhaled long-acting antimuscarinic, the patient showed relevant improvement of airway obstruction that had been irreversible at the time of the bronchodilator test. The lung function of the patient worsened when he interrupted the triple inhaled therapy. In addition, a 3-week pulmonary rehabilitation program markedly improved his physical performance. RESUMO A bronquiolite obliterante pós-infecciosa (BOPI) é uma doença das pequenas vias aéreas caracterizada por limitação fixa do fluxo aéreo. Portanto, os broncodilatadores e os corticosteroides inalatórios não são recomendados como opções de terapia de manutenção. Atualmente, o manejo da BOPI consiste apenas de um acompanhamento rigoroso dos pacientes afetados, visando à prevenção e ao tratamento precoce de infecções pulmonares. A incidência de BOPI tem aumentado na população pediátrica nos últimos anos. Os pacientes com BOPI caracterizam-se por um declínio progressivo da função pulmonar, associado a uma diminuição da capacidade funcional global. Relatamos aqui o caso de um homem relativamente jovem diagnosticado com BOPI, acompanhado por três anos. Ap

  15. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    Directory of Open Access Journals (Sweden)

    JUAN I. VARGAS RT.

    2003-01-01

    Full Text Available Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP, sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativa. Se trató con prednisona con buena respuesta. Al octavo mes de tratamiento, mientras se disminuía la dosis de esteroides, comenzó con disnea y tos y aparición de nuevas opacidades pulmonares radiológicos, las que regresaron rápidamente al aumentar la dosis de esteroides. Discutimos las causas posibles de la recidiva de esta patología y su relación con la disminución de la dosis de esteroidesAlthough relapses are frequent in bronchiolitis obliterans organizing pneumonia (BOOP, there is scant information regarding the causes underlying its occurrence. We report a 63 year old woman with clinical and radiological features compatible with BOOP. No underlying cause was identified so she was thought to have cryptogenic BOOP or cryptogenic organizing pneumonia (COP. A transbronchial lung biopsy demonstrated chronic organizing pneumonia and features of proliferative bronchiolitis. She was successfully treated with prednisone. On the eighth month of steroid therapy, while tapering the dose, she begun with cough and dyspnea and developed new lung infiltrates on the chest x-ray film. The infiltrates cleared rapidly after increasing the dose of steroids. We discuss the possible causes of relapse in BOOP and its relation to steroid therapy

  16. A case of bronchiolitis obliterans organizing pneumonia (BOOP) after breast conserving therapy for early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, Shinya; Kiryuu, Takuji; Maeda, Sunao; Hoshi, Hiroaki; Shimokawa, Kuniyasu [Gifu Univ. (Japan). School of Medicine; Kawaguchi, Shimpei

    2001-03-01

    A case of BOOP occurring after radiotherapy for breast cancer was reported. TBLB and BAL were performed at the time of diagnosis. This case suggested that radiographic changes began in the irradiated area, then later spread to non-irradiated areas. In this article, we discussed the peculiary radiographic image, pathological manifestation, BAL characteristics and clinical course in this sequela. (author)

  17. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    International Nuclear Information System (INIS)

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 ± 6.4 HU vs 26.1 ± 6.5 HU; P 25-75, (γ = -0.68-0.88, P ≤ 0.002). Volume percentages of xenon ventilation defects (35.0 ± 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 ± 18.6%). However, mismatches between the volume percentages were variable up to 21.4-33.3%. Mean effective dose of xenon CT was 1.9 ± 0.5 mSv. In addition to high-resolution anatomic information, xenon ventilation CT using dual-source and dual-energy technique demonstrates impaired regional ventilation and its heterogeneity accurately in children with BO without additional radiation exposure. (orig.)

  18. Bronquiolite obliterante pós-infecciosa: aspectos clínicos e exames complementares de 48 crianças Post-infectious bronchiolitis obliterans: clinical aspects and complementary testing of 48 children

    Directory of Open Access Journals (Sweden)

    Rosaly Vieira dos Santos

    2004-02-01

    obliterans (BO is variable. OBJECTIVE: Substantiate the clinical characteristics, the evolution and the complementary tests of 48 patients with post infectious bronchiolitis obliterans (BO. METHOD: Observational and retrospective study. Diagnosis of BO was based upon clinical criteria, CT scan findings and exclusion of other diseases. History prior to diagnosis and complementary tests were evaluated as well as initial and final values of oxygen saturation. RESULTS: Mean age of patients at the acute stage of the infectious disease was of 9.6 Thirty two of the patients were male. All were hospitalized during the acute stage, 14 of them (29% in the ICU. Four patients died two years after onset of acute bronchiolitis. During evolution all required emergency care due to exacerbation of the pulmonary condition and 24 (50% were hospitalized, 2 of them in the ICU. The majority continued presenting cough, wheezing, crackles and hyperinflation, however to a lesser degree. Mean of initial arterial saturation was of 89% and final of 92%. The most common infectious agents in the sputum samples were H. influenzae, S. pneumoniae and M. caterrhalis. Increased serum IgM and IgG were found in 9 and 7 patients respectively. The most frequent findings at thorax CT scan were mosaic perfusion, bronchioectasis, atelectasis and bronchial wall thickening. CONCLUSION: Post infectious BO is a chronic and severe disease with persistent symptoms that in general affect infants. Positive serum cultures and increased serum immunoglobulins are suggestive of a chronic infectious inflammatory condition.

  19. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo; Yang, Dong Hyun; Seo, Joon Beom; Chae, Eun Jin; Lee, Jeongjin [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Asan Medical Center, Songpa-gu, Seoul (Korea); Hong, Soo-Jong; Yu, Jinho; Kim, Byoung-Ju [University of Ulsan College of Medicine, Department of Pediatrics, Asan Medical Center, Seoul (Korea); Krauss, Bernhard [Siemens Medical Solutions AG-Computed Tomography, Forchheim (Germany)

    2010-09-15

    Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required. To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO). Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated. Xenon (14.6 {+-} 6.4 HU vs 26.1 {+-} 6.5 HU; P < 0.001) and CT density (-892.8 {+-} 25.4 HU vs -812.3 {+-} 38.7 HU; P < 0.001) values were significantly lower in hyperlucent regions than in normal lung regions. Xenon and CT density values showed significant positive correlation for the entire lung in 16 children ({gamma} = 0.55 {+-} 0.17, P < 0.001 or =0.017) and for hyperlucent regions in 13 children ({gamma} = 0.44 {+-} 0.16, P < 0.001 or =0.001-0.019). Indexed volumes and volume percentages of hyperlucent lung regions and ventilation defects showed strong negative correlations with forced expiratory volume [FEV1, ({gamma} = -0.64-0.85, P {<=} 0.006)], FEV1/forced vital capacity [FVC, ({gamma} = -0.63-0.84, P {<=} 0.008)], and forced midexpiratory flow rate [FEF{sub 25-75}, ({gamma} = -0.68-0.88, P {<=} 0.002). Volume percentages of xenon ventilation defects (35.0 {+-} 16.4%)] were not significantly different from those of hyperlucent lung regions (38.2 {+-} 18.6%). However, mismatches between the

  20. Clinical Observation on Aerosol Inhalation Combined with Oral Corti Cos-teroids in Treatment of Bronchiolitis Obliterans in Children%雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床分析

    Institute of Scientific and Technical Information of China (English)

    薛斌

    2016-01-01

    Objective To discuss and observe the clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children. Methods 116 cases of children with bronchiolitis obliterans diagnosed from December 2010 to June 2015 were collected and randomly divided into two groups with 58 cases in each, the observation group were treated with budesonide inhalation aerosol and oral corti costeroids, the control group were also treated budes-onide inhalation aerosol and oral corti costeroids, but the dose was different, and the treatment effects and asthma control situations were compared. Results The effective rate and asthma control scale were respectively 93.1%and (23.4±1.2) marks in the observation group, which were obviously better than those in the control group, P<0.05. Conclusion The clinical effect of aerosol inhalation combined with oral corti costeroids in treatment of bronchiolitis obliterans in children is satisfactory.%目的:探讨雾化吸入与口服糖皮质激素联合治疗儿童闭塞性细支气管炎临床疗效。方法方便选取2010年12月—2015年6月确诊的116例闭塞性细支气管炎患儿,随机分为观察组(布地奈德雾化吸入和口服泼尼松)和对照组(同观察组,但剂量不同)各58例,比较治疗效果和哮喘控制情况。结果观察组有效率为93.1%,哮喘控制得分为(23.4±1.2)分,均明显优于对照组(P<0.05)。结论雾化吸入与口服糖皮质激素协同治疗儿童闭塞性细支气管炎临床效果满意。

  1. Bronchiolitis - discharge

    Science.gov (United States)

    RSV bronchiolitis - discharge; Respiratory syncytial virus bronchiolitis - discharge ... Your child has bronchiolitis , which causes swelling and mucus to build up in the smallest air passages of the lungs. In the hospital, ...

  2. Comparison of pulmonary function between bronchial asthma and bronchiolitis obliterans in infants%婴幼儿支气管哮喘和闭塞性细支气管炎患儿肺功能比较

    Institute of Scientific and Technical Information of China (English)

    向莉; 饶小春; 焦安夏; 李珍; 任亦欣

    2012-01-01

    Objective To compare the results of pulmonary function test between bronchia asthma and bronchio-litis obliterans (BO) in infants. Methods Fifty-seven infants with bronchial asthma and 47 infants with BO aged from 0 to 3 years old were selected. Their tidal breathing flow-volume curves were tested by Master Screen Paed and the parameters were recorded including respiratory rate (RR), tidal volume over body weight (VT/kg) , ratio of inspiratory time to expiratory time (TI/TE) , ratio of time to reach tidal peak flow to total expiratory time (TPTEF/TE) , ratio of volume at tidal peak flow to total tidal volume (VPEF/VE). Pulmonary compliance (CrsSO/kg) and airway resistance (Rrs) were examined by the single occlusion technique. Results There was no significant difference in VT/kg between asthma group and BO (P < 0.05). RR and Rrs of BO group were significantly higher than that of asthma group (P < 0.05) . The levels of TI/TE, TPTEF/TE, VPEF/VE, TEF50/TIF50 and CrsSOAg in BO group were significantly lower than those in asthma group respectively (P < 0.05). Conclusions In infants with BO, compare with infants with asthma, the resistance of respiratory system and the degree of small airway obstruction increase, but the respiratory system compliance decreases. The evaluation of lung function can provide certain help to differentiate BO and asthma in infants.%目的 比较婴幼儿支气管哮喘和闭塞性毛细支气管炎(BO)患儿肺功能差异.方法 选择57例婴幼儿支气管哮喘和47例BO患儿,应用Master Screen Paed型肺功能仪测定潮气呼吸流量容积曲线,分析参数包括呼吸频率(RR)、每千克体质量潮气量(VT/kg)、吸呼比(TI/TE)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、呼吸气中期流速比值(TEF50/TIF50).单阻断法测定每千克体质量呼吸系统顺应性(CrsSO/kg)和呼吸系统阻力(Rrs).结果 支气管哮喘和BO患儿VT/kg差异无统计学意义(P > 0.05);BO患儿RR、Rrs显著高于支气管

  3. Test de marcha de seis minutos en niños con bronquiolitis obliterante postviral: Correlación con espirometría Six minute walk test in children with post-infectious obliterans bronchiolitis: Its relation with spirometry

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    DANIEL ZENTENO A

    2008-03-01

    Full Text Available la Bronquiolitis Obliterante (BO postviral produce alteraciones en la función pulmonar que pueden repercutir en la capacidad para realizar ejercicio, la cual se puede evaluar con el test de marcha de 6 minutos (TM6. Objetivo: Estudiar con esta prueba a niños con BO postviral y determinar la relación entre variables espirométricas y los resultados del TM6. Veintisiete pacientes, se estudiaron con espirometría basal y TM6. Se relacionaron variables espirométricas con resultados del TM6: distancia caminada, índice de Borg (IB, saturación de oxígeno (Sa0(2 y frecuencia cardíaca (FC, mediante Rho de Spearman utilizando SPSS 11,5. No hubo correlación entre la distancia caminada y ninguna variable espirométrica; la CVF sólo se correlacionó con Sa0(2 final (rho = 0,4; p = 0,02. El resto de las variables espirométricas se correlacionaron con IB, Sa0(2 y FC; destacando VEF1 con: IB (rho = -0,7; p Post infectious obliterans bronchiolitis (OB causes persistent pulmonary function impairment and could affect patient ability to perform exercise. Six minute-walk test (6MWT is a useful tool to study these aspects. Objective: Children with OB were evaluated with spirometry and 6MWT and the relationship between spirometrics measurements and 6MWT were determined. Twenty-seven children with OB were studied with a base line spirometry and 6MWT. Correlation between spirometry and 6MWT: covered distance, Borg index (BI, oxygen saturation (0(2S and heart rate (HR, were carried out using Rho of Spearman with SPSS 11.5. There was not relation between the covered distance and spirometrics values; only FVC correlates with final 0(2S (rho = 0.4; p = 0.02. The other spirometrics variables correlates with BI, 0(2S andHR; Interestingly FEV1correlates with: BI (rho = -0.7; p < 0.01, 0(2S (rho = 0.5; p < 0.01 and HR (rho = -0.5; p < 0.01. BI was significant related to FEV1/FVC (rho = -0.7; p < 0.01 and FEF25-75 (rho = -0.8; p < 0.01. Airflow obstruction

  4. Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans

    Directory of Open Access Journals (Sweden)

    Rita Mattiello

    2010-08-01

    Full Text Available OBJETIVO: Descrever a função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa (BOPI e avaliar potenciais fatores de risco para pior função pulmonar. MÉTODOS: A função pulmonar de 77 participantes, com idades de 8-18 anos, foi avaliada por meio de espirometria e pletismografia. Os seguintes parâmetros foram analisados: CVF, VEF1, FEF25-75%, VEF1/CVF, VR, CPT, VR/CPT, volume de gás intratorácico e specific airway resistance (sRaw, resistência específica das vias aéreas. Foi utilizada a regressão de Poisson para investigar os seguintes potenciais fatores de risco para pior função pulmonar: sexo, idade do primeiro sibilo, idade ao diagnóstico, história familiar de asma, exposição ao tabaco, tempo de hospitalização e tempo de ventilação mecânica. RESULTADOS: A idade média foi de 13,5 anos. Houve uma diminuição importante de VEF1 e FEF25-75%, assim como um aumento de VR e sRaw, característicos de doença obstrutiva das vias aéreas. Os parâmetros mais afetados e as médias percentuais dos valores previstos foram VEF1 = 45,9%; FEF25-75% = 21,5%; VR = 281,1%; VR/CPT = 236,2%; e sRaw = 665,3%. Nenhum dos potenciais fatores de risco avaliados apresentou uma associação significativa com pior função pulmonar. CONCLUSÕES: As crianças com BOPI apresentaram um padrão comum de comprometimento grave da função pulmonar, caracterizado por uma obstrução importante das vias aéreas e um expressivo aumento de VR e sRaw. A combinação de medidas espirométricas e pletismográficas pode ser mais útil na avaliação do dano funcional, assim como no acompanhamento desses pacientes. Fatores de riscos conhecidos para doenças respiratórias não parecem estar associados a pior função pulmonar em BOPI.OBJECTIVE: To describe the pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans (PIBO, as well as to evaluate potential risk factors for severe impairment of

  5. Avaliação do estado nutricional de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Assessment of nutritional status in children and adolescents with post-infectious bronchiolitis obliterans

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    Vera Lúcia Bosa

    2008-08-01

    bronchiolitis obliterans and to analyze associations with clinical and nutritional factors. METHODS: The study included 57 patients. Nutritional status was assessed using z scores for weight/age, stature/age, weight/stature in children, and stature/age and body mass index percentiles in adolescents. Body composition was assessed via tricipital skin folds, subscapular skin folds, and the sum of both plus the muscular circumference of the arm; pulmonary function was also investigated in subjects over 8 years old. RESULTS: The high percentages of malnutrition and risk for malnutrition are noteworthy: 21.7 and 17.5%, respectively. Among children, weight/age and stature/age detected higher percentages of malnutrition (21.6 and 16.2%, while weight/stature underestimated this diagnosis. Among adolescents, body mass index detected a high percentage of malnutrition (25% and of risk for malnutrition (20%. Body composition analysis detected 51% of patients with low muscle reserves, and the majority of patients had normal fat reserves. Compromised pulmonary function was associated with poor performance at exercise (r = 0.434; p = 0.024. Malnutrition and/or nutritional risk and low muscle reserves were significantly associated with the 6-minute walk test (p = 0.032; p = 0.030. There was no association between spirometry and the nutritional variables (p > 0.05. CONCLUSIONS: These results emphasize the need for nutritional intervention, and suggest that, in addition to using weight and height indices for nutritional assessment, it is necessary to combine these with an analysis of body composition, so that a larger number of patients with malnutrition and/or at an increased risk of developing malnutrition may be identified and correctly managed.

  6. Función pulmonar y calidad de vida en niños y adolescentes con bronquiolitis obliterante por adenovirus Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection

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    Stefhanie Nayar E

    2011-09-01

    Full Text Available Introducción: La infección por adenovirus es una causa importante de neumonía en niños chilenos. La bronquiolitis obliterante (BOPI es la complicación más importante. Existen pocos estudios donde evalúen la función pulmonar y la calidad de vida de los pacientes con BOPI. Objetivo: Evaluar la función pulmonar y la calidad de vida de los pacientes con BOPI y la correlación entre ambas variables. Métodos: Se incluyeron 14 niños con BOPI en elpoliclínico de la unidad de broncopulmonar de un hospital público de niños. Período de estudio: abril de 2009-abril de 2010. La función pulmonar se evaluó en una visita médica por espirometría, curva flujo / volumen y la determinación de volumen de gas intratorácico. Los índices analizados fueron los siguientes CVF, VEF1, FEV25-75, VEF1/CVF, VR,CPT, VR y VR / CPT. En la misma visita se realizó una encuesta auto-administrada de Calidad de Vida (PedsQL, versión 4.0, español de Chile para investigar la calidad de vida global, física y psi-cosocial. Se aplicó la correlación lineal de Pearson entre calidad de vida y los parámetros de función pulmonar. Se consideró estadísticamente significativo unp Introduction: Adenovirus infection is an important cause of pneumonia in Chilean children. Postinfectious Bronchiolitis Obliterans (PIBO is the most important complication. There are few studies assessing pulmonary function and quality of life in PIBO patients. Objective: The aim of this study is to assess the pulmonary function and the quality of life ofpatients with PIBO and the correlation between both variables. Methods: 14 children with PIBO in follow up at the pediatric pulmonology outpatient clinic of a public children hospital were included in this study. Study period: April 2009 - April 2010. Pulmonary function was assessed in a medical visit by spirometry, flow/volume curve and intrathoracic gas volume measurement. The following indices were analyzed FVC, FEV1, FEV25-75, FEV1/FVC

  7. Guía clínica para el diagnóstico y cuidado de niños/adolescentes con bronquiolitis obliterante post-infecciosa, 2009 Clinical guide for diagnosis and care of children and adolescents with post-infectious bronchiolitis obliterans, 2009

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    LUIS E VEGA-BRICEÑO

    2009-01-01

    Full Text Available La bronquiolitis obliterante (BO es un síndrome clínico poco frecuente en niños, caracterizado por la obstrucción crónica al flujo de aire asociado a cambios inflamatorios y distintos grados de fibrosis en la vía aérea pequeña. Si bien existen muchas etiologías, la causa más frecuente se asocia a infecciones respiratorias virales, principalmente adenovirus. No existe un consenso para establecer su diagnóstico; sin embargo, se considera un espectro de síntomas persistentes asociados a un patrón en mosaico, bronquiectasias y atelectasias persistentes. El papel de la biopsia pulmonar ha sido cuestionado por su bajo rendimiento, invasividad y complicaciones. No existe un tratamiento específico por lo que el manejo es soporte. Probablemente la mejor estrategia constituya el empleo de antibióticos en forma agresiva, soporte kinésico y nutricional constante y una precoz rehabilitación pulmonar. Estas guías clínicas representan un esfuerzo multidisciplinario, basado en evidencias actuales para brindar herramientas prácticas para el diagnóstico y cuidado de niños y adolescentes con BO post infecciosa.Bronchiolitis obliterans in children is an infrequent clinical syndrome, characterized by chronic airflow obstruction associated to inflammatory changes and different degrees of fibrosis in the small airways. Etiologies are varied but the most frequent one is the association with viral infections, mainly adenovirus. There is no consensus regarding diagnostic criteria, but a spectrum of persistent symptoms together with a mosaic pattern, bronchiectasis and persistent atelectasis is considered useful. Pulmonary biopsy has been questioned because of its low yield, invasiveness and complications. No specific treatment is available, therefore its treatment is supportive. Probably the best strategy is the aggressive use of antibiotics, constant kinesic and nutritional support and early pulmonary rehabilitation. This clinical guide represents

  8. Acute bronchiolitis.

    Science.gov (United States)

    Teshome, Getachew; Gattu, Rajender; Brown, Reginald

    2013-10-01

    Bronchiolitis is the most common lower respiratory tract infection to affect infants and toddlers. High-risk patients include infants younger than 3 months, premature infants, children with immunodeficiency, children with underlying cardiopulmonary or neuromuscular disease, or infants prone to apnea, severe respiratory distress, and respiratory failure. Bronchiolitis is a self-limited disease in healthy infants and children. Treatment is usually symptomatic, and the goal of therapy is to maintain adequate oxygenation and hydration. Use of a high-flow nasal cannula is becoming common for children with severe bronchiolitis.

  9. Thromboangiitis obliterans (Buerger's disease)

    OpenAIRE

    Sinclair, Nicholas R.; Laub, Donald R

    2016-01-01

    Thromboangiitis Obliterans is a non-atherosclerotic inflammatory disease of unknown etiology, which has a strong association with tobacco. We present current concepts on the pathophysiology and diagnosis, as well as a review in treatments.

  10. Bronquiolite obliterante: perfil clínico e radiológico de crianças acompanhadas em ambulatório de referência Bronquiolitis obliterante: perfil clínico y radiológico de 35 niños acompañados en ambulatorio de referencia Bronchiolitis obliterans: clinical and radiological profile of children followed-up in a reference outpatient clinic

    Directory of Open Access Journals (Sweden)

    Carolina Arcanjo Lino

    2013-03-01

    los pediatras frente a lactantes silbadores graves y perennes.OBJECTIVES: To describe the clinical and radiological characteristics of patients with bronchiolitis obliterans. METHODS: This is a retrospective and descriptive study. Data were collected from patients diagnosed with bronchiolitis obliterans between 2004 and 2008 in the Pediatric Pulmonology Clinic of Hospital Infantil Albert Sabin, in Ceará, Northeast Brazil. Such diagnosis was based on clinical and tomographic criteria. Previous history, clinical findings at the diagnosis, complementary exams, and follow-up data were evaluated. RESULTS: 35 children diagnosed with bronchiolitis obliterans were identified. There was a predominance of male patients (3:1. The mean age at the onset of symptoms was 7.5 months, and bronchiolitis obliterans was diagnosed at a mean age of 21.8 months. The most common clinical findings were crackles/wheezing, tachypnea, dyspnea, and chest deformity. Post-infectious etiology was the main cause of bronchiolitis obliterans. Predominant findings at chest X-ray and high resolution computed tomography were peri-bronchial thickening and mosaic pattern, respectively. The treatment was variable and individualized. The majority of patients improved during follow-up, despite the persistence of respiratory symptoms. CONCLUSIONS: In this study, the predominance of male patients and post-infectious etiology was noted, corroborating scientific literature. The most common tomographic findings were similar to those described in previous studies (mosaic pattern, peri-bronchial thickening, and bronchiectasis. Evidence about the treatment of this disease is still lacking. The diagnosis was delayed, which indicates that clinical suspicion of bronchiolitis obliterans is necessary in children with persistent and severe wheezing.

  11. 儿童闭塞性细支气管炎的临床表现与高分辨率CT特点%Clinical manifestations and high resolution CT features of bronchiolitis obliterans

    Institute of Scientific and Technical Information of China (English)

    周俊霖; 丁山; 朱晓华; 郑巍

    2012-01-01

    Objective To study the clinical manifestations and high resolution CT( HRCT) characteristics of bronchiolitis obliter-ans(BO) , so that to improve the understanding of it. Methods Clinical and CT data in 27 patients(22 boys and 5 girls, aged from 2 months to 5 years, and mean age 15. 4 months) with clinical confirmation of BO were retrospectively analysed. All the patients pres-ented with persistent cough and asthma. All cases underwent chest radiograph, HRCT examinations and blood gas analysis. 10 ca-ses and 5 cases underwent bronchoscopy and pulmonary function test, respectively. Results In 27 cases,24 cases were post-infec-tions BO and the others were premature infants after injury of lungs. Hypoxemia in 14 cases and respiratory failure in 4 cases were showed by blood gas analysis. Ten cases who underwent bronchoscopy showed chronic endobronchial infection. HRCT features in-cluded direct signs (peripheral bronchiectasis and bronchial wall thickening in 16 cases, centrilobular nodules in 5 cases) and indirect signs(bronchiectasis and bronchial wall thickening in 20 cases, air trapping signs in 5 cases, mosaic perfusion signs in 25 cases, con-solidation in 10 cases and atelectasis in 5 cases). Conclusion In most of the patients with BO present following infections. HRCT is of important value in the early diagnosis and evaluation of outcome of BO.%目的 探讨闭塞性支气管炎(BO)的临床表现与高分辨率CT(HRCT)特点,提高对本病的认识.方法 回顾性分析27例经临床诊断证实的儿童闭塞性细支气管炎的临床和CT资料,年龄2个月~5岁,平均15.4月,男22例,女5例.反复咳喘病程均在6周以上.27例患儿均行X线胸片,肺部高分辨率CT及血气分析.10例行电子纤维支气管镜检查,5例行肺功能检查.结果 27例确诊为BO患儿,3例为早产儿肺损伤后,余24例为感染后.血气分析示低氧血症14例,呼吸衰竭4例.10例行电子纤维支气管镜检查均提示有支气管内膜慢性感

  12. Radiographic finding in broncholitis obliterans after lung transplantation

    International Nuclear Information System (INIS)

    This paper examines the radiographic findings of bronchiolitis obliterans (BO) after lung transplantation. Among the 55 single- and double-lung transplantations performed at the Toronto General Hospital, 41 have survived longer than 3 months and 7 have developed clinical BO. The chest radiographs, CT scans (where available) and medical records of these 7 patients were reviewed retrospectively, with the use of appropriate controls, and results were correlated with pathologic findings. Pathologic specimens demonstrated widespread BO in 3 patients (open lung biopsy), mild acute rejection with possible BO in 1 (transbronchial biopsy [TBBx]), undefined abnormality with some BO in 1 (TBBx), and acute rejection in 2 (TBBx)

  13. Thromboangiitis obliterans (Buerger disease

    Directory of Open Access Journals (Sweden)

    Jessica Seebald, BS

    2015-10-01

    Full Text Available Thromboangiitis obliterans (Buerger disease is an occlusive, nonatherosclerotic, inflammatory vasculitis that causes ischemia in small and medium vessels. Most commonly, Buerger disease is diagnosed in 40- to 45-year-old men with a heavy smoking history. Our case exemplifies the most common presentation, diagnosis, and treatment in a 53-year-old male smoker who presents with arm pain and dusky cool fingers. A Buerger diagnosis requires exclusion of autoimmune, diabetic, and embolic causes. The only recognized treatment for this disease is smoking cessation.

  14. Acute viral bronchiolitis and its sequelae in developing countries.

    Science.gov (United States)

    Fischer, Gilberto Bueno; Teper, Alejandro; Colom, Alejandro J

    2002-12-01

    Acute viral bronchiolitis (AVB) is a common disease found throughout the world. Various aspects of it are being studied: its epidemiology, diagnosis, prognosis and treatment. Most of these studies are being conducted in developed countries, with only a few taking place in developing countries. Risk factors such as poor nutrition, an adverse environment and early weaning should be studied where these features are common. Treatment aspects such as cost-effectiveness in low income settings need further study. Use of ribavirin and respiratory syncytial virus (RSV)-immunoglobulin are good examples. Post-bronchiolitic sequelae also need to be studied in low income countries. There is evidence that bronchiolitis obliterans is unusually frequent in some Latin-American countries such as Argentina and Brazil. It will be helpful to undertake combined studies in countries with the same socio-economics, investigating the preventive and management aspects of AVB and its sequelae to reduce the morbidity and mortality.

  15. Elective preterm delivery as a management option in cryptogenic organizing pneumonia.

    Science.gov (United States)

    Holder, Kelly L; Scardo, James A; Laye, M Ryan

    2011-06-01

    Bronchiolitis obliterans organizing pneumonia, now termed as cryptogenic organizing pneumonia (COP), is a fibrotic lung disease of the small airways with the potential to progress to end-stage lung disease. COP in pregnancy carries a high risk of maternal and neonatal complications and only two prior cases have been reported. This is the first case of pre-existing COP in pregnancy. We report a 16-year-old primigravid with COP who elected inpatient management and preterm delivery as a successful management option.

  16. Bronchiolitis: the recent evidence.

    Science.gov (United States)

    Mustafa, Ghulam

    2014-01-01

    Bronchiolitis is an active area of research across the spectrum from genetic mechanisms to population-based research. Surveillance studies are identifying new causes of bronchiolitis and exploring the role of viral co-infections. The studies have revealed that comorbidities are an important determinant to predict the course of the illness. Also the specific physical findings and diagnostic tests used to predict the outcomes in bronchiolitis do not have high predictive value. The pulse oximetry, probably, is a double edge sword. It has contributed to better childcare but is also likely contributing to longer hospitalizations and greater use of health care resources. The available data is yet largely against the routine use of bronchodilators or corticosteroids, though a combination of these two looks promising future trend. The role of nebulized hypertonic saline in bronchiolitis is getting a wider acceptance and is likely to get established a part of routine care.

  17. Severe Organizing Pneumonia after Two Cycles of Docetaxel as Fourth-Line Chemotherapy for Advanced Non-Small Cell Carcinoma of the Lung

    Directory of Open Access Journals (Sweden)

    Jens Hasskarl

    2009-02-01

    Full Text Available Organizing pneumonia (formerly known as bronchiolitis obliterans organizing pneumonia, BOOP is an inflammatory process of the bronchioles that can lead to the destruction of small airways and surrounding lung tissue. Although the majority of cases are idiopathic, certain chemicals and drugs can induce OP. Here, we report a 54-year-old male patient with advanced non-small cell lung cancer (NSCLC who developed therapy-associated OP. He had undergone several other chemotherapies before being switched to docetaxel as monotherapy (75 mg/m2. Treatment was initially well tolerated, but after the second cycle the patient developed increasing shortness of breath. Computed tomography (CT for staging after the second cycle showed bilateral predominantly interstitial infiltration highly suggestive of acute lung fibrosis. Bronchoscopy revealed signs of chronic bronchitis and watery discharge from both lungs. Bronchoalveolar lavage and transbronchial needle biopsy was performed. Based on histopathologic examination, diagnosis of OP was made. After cessation of docetaxel and initial high dose steroids, the infiltration ameliorated rapidly. This is the second case in the literature that associates docetaxel with rapid onset of bronchiolitis obliterans. Therefore, patients with lung cancer receiving docetaxel who develop respiratory symptoms should be suspected to develop OP.

  18. Infectious pathogens and bronchiolitis outcomes.

    Science.gov (United States)

    Hasegawa, Kohei; Mansbach, Jonathan M; Camargo, Carlos A

    2014-07-01

    Bronchiolitis is a common early childhood illness and an important cause of morbidity, it is the number one cause of hospitalization among US infants. Bronchiolitis is also an active area of research, and recent studies have advanced our understanding of this illness. Although it has long been the conventional wisdom that the infectious etiology of bronchiolitis does not affect outcomes, a growing number of studies have linked specific pathogens of bronchiolitis (e.g., rhinovirus) to short- and long-term outcomes, such as future risk of developing asthma. The authors review the advent of molecular diagnostic techniques that have demonstrated diverse pathogens in bronchiolitis, and they review recent studies on the complex link between infectious pathogens of bronchiolitis and the development of childhood asthma.

  19. Bronchiolitis in Kartagener's syndrome.

    Science.gov (United States)

    Homma, S; Kawabata, M; Kishi, K; Tsuboi, E; Narui, K; Nakatani, T; Saiki, S; Nakata, K

    1999-12-01

    The association of diffuse bronchiolitis in patients with Kartagener's syndrome (KS) has not been reported previously. The aim of this study was to present the morphological characteristics of bronchiolitis in patients with KS. Eight patients (four males, four females; mean age 37.9+/-18.7 yrs), clinically diagnosed as KS with the classical triad of chronic pansinusitis, bronchiectasis and situs in versus with dextrocardia, were evaluated. Routine chest radiography showed bronchiectasis and dextrocardia in all patients. Chest computed tomography (CT) showed diffuse centrilobular small nodules up to 2 mm in diameter throughout both lungs in six out of eight patients. Pulmonary function tests revealed marked obstructive impairment in all patients (forced expiratory volume in one second 57.0+/-11.3%, residual volume/total lung capacity 45.+/-12.7%, maximum midexpiratory flow 0.92+/-0.72 L x s(-1), forced vital capacity 74.1+/-12.2% (all mean +/- SD)). The examination of cilial movement of the bronchus revealed immotility in all of the five patients examined. The ultrastructure showed ciliary dynein arm defects in all patients. Histopathological examination of lung specimens obtained at autopsy or by video-assisted thoracoscopic surgery showed obliterative thickening of the walls of the membranous bronchioli with infiltration of lymphocytes, plasma cells and neutrophils, but most of the distal respiratory bronchioli were spared and alveolar spaces were overinflated. Pathologically, the diffuse centrilobular small nodules on the chest CT mainly corresponded to membranous bronchiolitis. This is the first report demonstrating that the association of diffuse bronchiolitis might be one of the characteristic features of the lung in Kartagener's syndrome.

  20. Treatment of acute viral bronchiolitis.

    Science.gov (United States)

    Eber, Ernst

    2011-01-01

    Acute viral bronchiolitis represents the most common lower respiratory tract infection in infants and young children and is associated with substantial morbidity and mortality. Respiratory syncytial virus is the most frequently identified virus, but many other viruses may also cause acute bronchiolitis. There is no common definition of acute viral bronchiolitis used internationally, and this may explain part of the confusion in the literature. Most children with bronchiolitis have a self limiting mild disease and can be safely managed at home with careful attention to feeding and respiratory status. Criteria for referral and admission vary between hospitals as do clinical practice in the management of acute viral bronchiolitis, and there is confusion and lack of evidence over the best treatment for this condition. Supportive care, including administration of oxygen and fluids, is the cornerstone of current treatment. The majority of infants and children with bronchiolitis do not require specific measures. Bronchodilators should not be routinely used in the management of acute viral bronchiolitis, but may be effective in some patients. Most of the commonly used management modalities have not been shown to have a clear beneficial effect on the course of the disease. For example, inhaled and systemic corticosteroids, leukotriene receptor antagonists, immunoglobulins and monoclonal antibodies, antibiotics, antiviral therapy, and chest physiotherapy should not be used routinely in the management of bronchiolitis. The potential effect of hypertonic saline on the course of the acute disease is promising, but further studies are required. In critically ill children with bronchiolitis, today there is little justification for the use of surfactant and heliox. Nasal continuous positive airway pressure may be beneficial in children with severe bronchiolitis but a large trial is needed to determine its value. Finally, very little is known on the effect of the various

  1. Viral bronchiolitis for the clinician.

    Science.gov (United States)

    Fitzgerald, Dominic A

    2011-04-01

    Viral bronchiolitis is common, and about 98-99% of infants are managed in the home. Because about 95% of infants < 2 years old are infected with respiratory syncytial virus, however, bronchiolitis is the commonest reason for admission to hospital in the first 6 months of life. It is usually a self-limiting condition lasting around a week in previously well children. About 1% of infants are admitted to hospital, and about 10% of hospitalised infants will require admission to the intensive care unit. Respiratory syncytial virus is isolated from about 70% of infants hospitalised with bronchiolitis. The emphasis of hospital treatment is to ensure adequate hydration and oxygenation. Other than supplemental oxygen, little in the way of pharmacological treatment has been demonstrated to alter the course of the illness or the risk of wheezing in the months following bronchiolitis.

  2. [Thromboangiitis obliterans (Buerger's disease): update 2015].

    Science.gov (United States)

    Klein-Weigel, Peter; Volz, Theresa Sophie; Richter, Jutta

    2015-10-01

    Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors. PMID:26445249

  3. [Thromboangiitis obliterans (Buerger's disease): update 2015].

    Science.gov (United States)

    Klein-Weigel, Peter; Volz, Theresa Sophie; Richter, Jutta

    2015-10-01

    Thromboangiitis obliterans (Buerger's disease) is a vasculitis with undulating clinical course multisegmentarily affecting small and medium-sized arteries and veins. The disease is closely linked to tobacco-use. Increasing knowledge of autoimmunologic mechanisms in the complex pathophyiology of the disease let to the formulation of an autoimmunity-hypothesis now serving as a new paradigma. New treatment options comprise progenitor-cell-therapy, immunoadsorption, use of sendothelin-receptor-blocking agent Bosentan, and prescriptions of antiphosphodiesterase-V-inhibitors.

  4. O espectro clínico e radiológico da pneumonia em organização: análise retrospectiva de 38 casos Clinical and radiographic spectrum of organizing pneumonia: retrospective analysis of 38 cases

    Directory of Open Access Journals (Sweden)

    FABRÍCIO PICCOLI FORTUNA

    2002-11-01

    Full Text Available A pneumonia em organização, acompanhada ou não de bronquiolite obliterante, é uma condição anatomopatológica pulmonar específica com uma grande variedade de apresentações clínicas e radiológicas. A pneumonia em organização pode ser idiopática ou secundária a várias doenças, incluindo infecções e drogas. Objetivos: Descrever as manifestações clínicas, dados radiológicos e espirométricos de pacientes com pneumonia em organização. Métodos: Análise retrospectiva de pacientes com o diagnóstico de pneumonia em organização. Resultados: 38 pacientes foram incluídos na análise. Quatorze apresentavam também condições clínicas relacionadas à pneumonia em organização, e estes mais freqüentemente apresentaram infiltração pulmonar difusa (três de quatro casos e bronquiolite obliterante associada (57% vs. 20%, p = 0,05. Dos 13 pacientes com bronquiolite obliterante associada apenas um era assintomático e dois apresentavam lesões localizadas (15%. De oito pacientes assintomáticos com lesões localizadas, nenhum possuía bronquiolite obliterante associada, e a apresentação radiológica freqüentemente mimetizou carcinoma brônquico. A espirometria de modo geral não contribuiu sobremaneira para o diagnóstico, provavelmente devido à alta prevalência de tabagismo na amostra. Conclusões: A pneumonia em organização possui apresentação clínica e radiológica variada. Fatores que sugerem a ausência de bronquiolite obliterante são a ausência de sintomas e lesões radiológicas localizadas, e esta forma da doença mais freqüentemente deve ser diferenciada de carcinoma brônquico na prática clínica.Organizing pneumonia, whether or not accompanied by bronchiolitis obliterans, is a specific anatomicopathological condition of the lungs that can present in a variety of clinical and radiographic ways. It can be either idiopathic or secondary to a number of diseases, including infection and drugs. Objectives: To

  5. Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze

    NARCIS (Netherlands)

    Schuurhof, Annemieke; Janssen, Riny; de Groot, Hanneke; Hodemaekers, Hennie M.; de Klerk, Arja; Kimpen, Jan L. L.; Bont, Louis

    2011-01-01

    Background: Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Following RSV bronchiolitis, 50% of children develop post-bronchiolitis wheeze (PBW). Animal studies have suggested that interleukin (IL)-10 plays a critical role in the pathogenesis of RSV bronchioli

  6. Acute bronchiolitis in infants, a review

    OpenAIRE

    Øymar, Knut; Skjerven, Håvard Ove; Mikalsen, Ingvild Bruun

    2014-01-01

    Acute viral bronchiolitis is one of the most common medical emergency situations in infancy, and physicians caring for acutely ill children will regularly be faced with this condition. In this article we present a summary of the epidemiology, pathophysiology and diagnosis, and focus on guidelines for the treatment of bronchiolitis in infants. The cornerstones of the management of viral bronchiolitis are the administration of oxygen and appropriate fluid therapy, and overall a “min...

  7. Cerebral angiographic findings in thromboangiitis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    No, Young J.; Lee, Eun M.; Kim, Jong S. [University of Ulsan, Department of Neurology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea); Lee, Deok H. [University of Ulsan, Department of Neuroradiology, Asan Medical Center, Song Pa, PO Pox 145, Seoul (Korea)

    2005-12-01

    Transient ischemic attacks (TIAs) or ischemic stroke may complicate thromboangiitis obliterans (TAO). However, there has been debate regarding the mechanism of ischemic stroke in TAO. We report the case of a patient with TAO who developed repeated TIAs. An angiogram showed multiple alternative areas of arterial occlusions in the distal segments of both middle cerebral arteries. Extensive collateral vessels around the occluded segment were also observed, which resembled the ''tree root'' or ''corkscrew'' vessels described in the peripheral arteries in TAO. Our patient illustrates that cerebral manifestations of TAO may occur with vascular changes that are identical with those encountered in the limb arteries in TAO. (orig.)

  8. Testing for meningitis in children with bronchiolitis.

    Science.gov (United States)

    Stefanski, Michael; Williams, Ronald; McSherry, George; Geskey, Joseph

    2014-01-01

    Viral bronchiolitis accounts for almost 20% of all-cause hospitalizations of infants (ie, children younger than age 1 year). The annual incidence of fever in viral bronchiolitis has been documented at 23% to 31%. However the incidence of concurrent serious bacterial infections is low (1%-7%), with meningitis occurring in less than 1% to 2% of cases, but lumbar puncture is performed in up to 9% of viral bronchiolitis cases. To our knowledge, no study has examined clinical factors that influence a physician’s decision to perform a lumbar puncture in the setting of viral bronchiolitis. We present a retrospective, case-control study of hospitalized infants younger than one year diagnosed with viral bronchiolitis who underwent lumbar puncture as part of an evaluation for meningitis. The objective of the study was to determine clinical factors that influence a physician’s decision to perform a lumbar puncture in the setting of viral bronchiolitis. Although the presence of apnea, cyanosis, meningeal signs, positive urine culture results, and young age were factors found to be preliminarily associated with the performance of a lumbar puncture in the setting of bronchiolitis, young age was the only significant clinical factor found after multivariable regression; no other demographic, clinical, laboratory, or radiologic variables were found to be significant.

  9. [Pathophysiology and diagnosis for arteriosclerosis obliterans].

    Science.gov (United States)

    Sasaki, Hisao; Konisi, Keiko

    2002-08-01

    Patients with arteriosclerosis obliterans, or peripheral arterial disease have been conventionally diagnosed and treated from only the viewpoint of peripheral arterial circulation. These concepts may have improved the quality of life for patients, but could not contribute the prognosis of life, because peripheral arterial disease is associated with an increased risk of the coronary disease and cerebrovascular disease. Intermittent claudication, the most common symptom of peripheral arterial disease, results from flow-reducing lesions in the arteries of the lower extremity that cause exercise-induced muscle ischemia. In order to evaluate intermittent claudication, many kinds of noninvasive diagnostic studies, including ABPI (ankle brachial pressure index) and the measurement of claudication distance, et al have been proposed. We have used the recovery time of the ischemic reaction at foot sole, plethysmography, thermography, laser doppler flowmetry, or NIRS (near-infrared spectroscopy) after walking test, rather than ABPI. These examinations will be superior to ABPI to evaluate effects after ergotherapy or pharmacotherapy for patients with intermittent claudication. Carotid artery sclerosis may be a good marker of systemic atherosclerosis. By our assessment of risk factors, the progression of atherosclerotic change in carotid artery was strongly correlated with two risk factors, such as smoking and systolic blood pressure. In the cholesterol analysis, Lp (a) was only high risk factor for atherosclerotic change of carotid artery. Recent technical advances, adequate evaluation of systemic atherosclerosis, and reduction of risk factors should improve the prognosis of patients with peripheral arterial disease. PMID:12373817

  10. [Pediatrics. New treatment options for viral bronchiolitis].

    Science.gov (United States)

    Rochat, I; Hafen, G

    2013-01-16

    The combination of nebulized epinephrine and high dose dexamethasone, or nebulized hypertonic saline, are promising new therapeutic strategies for viral bronchiolitis in the young infant. However, further research is needed before a general recommendation can be given.

  11. Pulse oximetry in bronchiolitis: is it needed?

    Directory of Open Access Journals (Sweden)

    Hendaus MA

    2015-10-01

    Full Text Available Mohamed A Hendaus,1,2 Fatima A Jomha,3 Ahmed H Alhammadi,1,2 1Department of Pediatrics, General Pediatrics Division, Hamad Medical Corporation, 2Weill-Cornell Medical College, Doha, Qatar; 3School of Pharmacy, Lebanese International University, Khiara, Lebanon Abstract: Infants admitted to health-care centers with acute bronchiolitis are frequently monitored with a pulse oximeter, a noninvasive method commonly used for measuring oxygen saturation. The decision to hospitalize children with bronchiolitis has been largely influenced by pulse oximetry, despite its questionable diagnostic value in delineating the severity of the illness. Many health-care providers lack the appropriate clinical fundamentals and limitations of pulse oximetry. This deficiency in knowledge might have been linked to changes in the management of bronchiolitis. The aim of this paper is to provide the current evidence on the role of pulse oximetry in bronchiolitis. We discuss the history, fundamentals of operation, and limitations of the apparatus. A search of the Google Scholar, Embase, Medline, and PubMed databases was carried out for published articles covering the use of pulse oximetry in bronchiolitis. Keywords: bronchiolitis, children, monitor, oxygen

  12. TCM Treatment of Thromboangiitis Obliterans -A Report of 64 Cases

    Institute of Scientific and Technical Information of China (English)

    门军章; 门九章

    2005-01-01

    @@ Thromboangiitis Obliterans (TAO), a common peripheral vascular disease with a long illness course and grave sufferings, can cause acromelic gangrene, ulcer and even amputation at the late stage. We have for many years used TCM syndrome differentiation to diagnose and treat the disease with good therapeutic results. The treatment of 64 TAO cases from 2001 to 2002 is reported as follows.

  13. Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze

    Directory of Open Access Journals (Sweden)

    Hodemaekers Hennie M

    2011-09-01

    Full Text Available Abstract Background Respiratory syncytial virus (RSV is the most common cause of bronchiolitis in infants. Following RSV bronchiolitis, 50% of children develop post-bronchiolitis wheeze (PBW. Animal studies have suggested that interleukin (IL-10 plays a critical role in the pathogenesis of RSV bronchiolitis and subsequent airway hyperresponsiveness. Previously, we showed that ex vivo monocyte IL-10 production is a predictor of PBW. Additionally, heterozygosity of the single-nucleotide polymorphism (SNP rs1800872 in the IL10 promoter region was associated with protection against RSV bronchiolitis. Methods This study aimed to determine the in vivo role of IL-10 in RSV pathogenesis and recurrent wheeze in a new cohort of 235 infants hospitalized for RSV bronchiolitis. IL-10 levels in nasopharyngeal aspirates (NPAs were measured at the time of hospitalization and the IL10 SNP rs1800872 genotype was determined. Follow-up data were available for 185 children (79%. Results Local IL-10 levels during RSV infection turned out to be higher in infants that later developed physician diagnosed PBW as compared to infants without PBW in the first year after RSV infection (958 vs 692 pg/ml, p = 0.02. The IL10 promoter SNP rs1800872 was not associated with IL-10 concentration in NPAs. Conclusion The relationship between high local IL-10 levels during the initial RSV infection and physician diagnosed PBW provides further evidence of the importance of the IL-10 response during RSV bronchiolitis.

  14. Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis.

    Science.gov (United States)

    Pickles, Raymond J; DeVincenzo, John P

    2015-01-01

    Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie bronchiolitis. The most common aetological agents causing bronchiolitis in young children are the respiratory viruses, and of the commonly encountered respiratory viruses, respiratory syncytial virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of this review. By reviewing the available histopathology of RSV bronchiolitis, both in humans and relevant animal models, we identify hallmark features of RSV infection of the distal airways and focus attention on the consequences of columnar cell cytopathology occurring in the bronchioles, which directly impacts the development of bronchiolar obstruction, inflammation and disease.

  15. Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

    OpenAIRE

    Flynn, Ryan; Du, Jing; Veenstra, Rachelle G.; Reichenbach, Dawn K.; Panoskaltsis-Mortari, Angela; Taylor, Patricia A.; Freeman, Gordon J.; Serody, Jonathan S.; Murphy, William J.; Munn, David H.; Sarantopoulos, Stefanie; Luznik, Leo; Maillard, Ivan; Koreth, John; Cutler, Corey

    2014-01-01

    T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model.Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.

  16. Pneumothorax complicating bronchiolitis in an infant

    International Nuclear Information System (INIS)

    Pneumothorax is an uncommon complication of bronchiolitis. This case illustrates an unusual pattern of atelectasis of the right lung with pleural air surrounding the right upper lobe and the remainder of the lung expanded. It is thought that the hyperinflated lung is unable to collapse as a result of the 'ball valve' effect of air trapping. (orig.)

  17. Bronchiolitis: what the clinician should know

    Directory of Open Access Journals (Sweden)

    Roberto Antonucci

    2015-10-01

    Full Text Available Bronchiolitis is an acute infection of the lower respiratory tract affecting infants and young children, with Respiratory Syncytial Virus (RSV being the most common pathogen. Bronchiolitis is generally a mild disease, but may present with severe signs and symptoms requiring hospitalization. Risk factors including prematurity, bronchopulmonary dysplasia, immunodeficiency and congenital heart defects may predispose patients to develop a severe disease. The diagnosis should be based on clinical evaluation, without supportive radiographic and laboratory studies. Etiological diagnosis may be helpful to decrease the hospital transmission of virus and to avoid inappropriate use of antibiotics.The mainstay of therapy for bronchiolitis is supportive care, which should be directed at maintaining adequate oxygenation, ensuring a proper respiratory toilet, and meeting the requirements of fluids and nutrition. The use of nebulized hypertonic saline should be limited to hospitalized patients. Severe respiratory failure may require mechanical ventilatory support. Neither corticosteroids nor antibiotics offer consistent benefit in the treatment of bronchiolitis, and thus should not be used. A trial of a bronchodilator may be appropriate, but should be continued exclusively if a prompt favorable response occurs. Effective interventions to prevent the spread of RSV infection include hand washing or disinfection by caregivers and contact isolation. The use of palivizumab, a monoclonal antibody directed against RSV, is a safe prophylactic option, but should be restricted to children at high-risk for severe RSV disease, during the epidemic period. Current evidence suggests that early RSV bronchiolitis predisposes children to recurrent wheezing and asthma in the first decade of life.Proceedings of the 11th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy · October 26th-31st, 2015 · From the womb to the adultGuest Editors: Vassilios

  18. Surfactant abnormalities in infants with severe viral bronchiolitis.

    OpenAIRE

    Dargaville, P A; South, M; McDougall, P N

    1996-01-01

    To determine whether abnormalities of pulmonary surfactant occur in infants with acute viral bronchiolitis, surfactant indices were measured in lung lavage fluid from 12 infants with severe bronchiolitis and eight infants without lung disease. Compared with controls, the bronchiolitis group showed deficiency of surfactant protein A (1.02 v 14.4 micrograms/ml) and disaturated phosphatidylcholine (35 v 1060 micrograms/ml) which resolved as the disease improved. Surfactant functional activity wa...

  19. Prevention and nursing care of the complications occurred in interventional therapy for arteriosclerosis obliterans of lower extremity

    International Nuclear Information System (INIS)

    Objective: To discuss the prevention and nursing care of the perioperative complications occurred in interventional therapy for arteriosclerosis obliterans of lower extremity. Methods: During the period of July 2006 to June 2009, interventional treatment for the arteriosclerosis obliterans of lower extremity was performed in 380 cases. The clinical data and complications were reviewed and analyzed, and the prevention and nursing care of the complications were summarized. Results: Complications occurred in 41 cases. During the surgery, vascular rupture or arterial dissection occurred in 5 cases, hypoglycemia reaction in 3 cases and elevation of blood pressure in 2 cases. The complications,which occurred after the treatment,included acute arterial thrombosis (n=3), deep vein thrombosis (n=2), bleeding of different tissues or organs (n=17), acute myocardial infarction (n=2), pseudoaneurysm (n=2), excessive lower limb perfusion syndrome (n=4) and compression sores (n=1). Conclusion: Detailed information of medical history, careful observation of clinical condition, intensive care of patient, adequate preparation of medical materials, seriously handing over the duty to the next shift and taking one's turn on duty, etc. are all the effective measures to prevent and to reduce the occurrence of complications. (authors)

  20. Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment.

    Science.gov (United States)

    Schindler, Katja; Schima, Wolfgang; Kaliman, Josef F

    2010-08-01

    Cryptogenic organizing pneumonia (formerly known as bronchiolitis obliterans organizing pneumonia) is a clinicopathological entity with characteristical radiographic findings such as bilateral, asymmetrical, sometimes migrating, patchy infiltrates in chest radiograph and ground-glass opacities in computed tomography. The disease has been observed in the context of gastrointestinal disorders, certain lung infections, autoimmune-mediated diseases (such as Wegener granulomatosis), inhalation of toxic fumes, bone marrow transplantation and administration of drugs. The benzofuran amiodarone, a commonly used antiarrythmic drug for atrial fibrillation, can exhibit several pulmonary adverse effects, amongst them cryptogenic organizing pneumonia as a rarely diagnosed and published one. We report a case of cryptogenic organizing pneumonia secondary to amiodarone treatment, its clinical course with significant improvement of clinical symptoms within a few days after discontinuation of amiodarone treatment and administration of corticosteroids. Also the infiltrations found in chest X-ray and computed tomography responded well and showed remarkable resolution tendency quickly. During 5 months of corticoid therapy pulmonary abnormalities gradually resolved almost completely and remained equal during the 8 months follow-up after corticoid termination. PMID:20668958

  1. Production of interferon in respiratory syncytial virus bronchiolitis.

    OpenAIRE

    Isaacs, D

    1989-01-01

    Production of interferon alfa in vitro was significantly reduced during acute respiratory syncytial virus bronchiolitis but subsequently returned to normal. Nasopharyngeal and endotracheal interferon alfa were detected intermittently and in low concentrations. The degree of impairment of in vitro production and poor in vivo production of interferon alfa suggest the need for a therapeutic trial of nebulised or systemic interferon in acute bronchiolitis.

  2. RSV bronchiolitis in healthy term infants: prediction and pathogenesis

    NARCIS (Netherlands)

    Houben, M.L.

    2011-01-01

    The global estimated annual numbers of non-severe and severe (i.e. hospitalized) respiratory syncytial virus (RSV) infections in children younger than five are 34 and 3.4 million. Most children with RSV bronchiolitis are treated outside the hospital and most children with RSV bronchiolitis are healt

  3. Interleukin-15 is associated with disease severity in viral bronchiolitis.

    Science.gov (United States)

    Leahy, T Ronan; McManus, Ross; Doherty, Derek G; Grealy, Robert; Coulter, Tanya; Smyth, Paul; Blackshields, Gordon; Sheils, Orla; Carr, Michael J; Purandare, Nikhil; Geary, Michael; Hodemaekers, Hennie M; Janssen, Riny; Bont, Louis; Slattery, Dubhfeasa; Ryan, Thomas

    2016-01-01

    Disease severity in viral bronchiolitis in infancy is difficult to predict and has been linked to host innate immunity. The study aimed to investigate the innate cytokine interleukin-15 (IL-15) as a marker of disease severity.A prospective single-centre observational study was conducted in a university-affiliated paediatric teaching hospital, comparing children (0-18 months) hospitalised for viral bronchiolitis, those admitted to the paediatric intensive care unit with severe disease and healthy age-matched controls. IL-15-related parameters were compared between groups. PCR and microRNA (miRNA) sequencing was undertaken on natural killer (NK) cells collected from study participants.Samples from 88 children with viral bronchiolitis and 43 controls enrolled between 2009 and 2012 were analysed. Peripheral blood mononuclear cell (PBMC) IL-15 mRNA expression was significantly higher in those with moderate severity bronchiolitis compared with controls and those with severe disease. Serum IL-15 levels correlated with disease severity. The relative frequency of NK cells in peripheral blood was significantly reduced in participants with bronchiolitis. The NK cell miRNA transcriptome in bronchiolitis was distinct. Targets of de-regulated miRNA were differentially expressed in bronchiolitis, including JAK3, STAT5A and NFKB1 on the IL-15 signalling pathway.IL-15 is associated with disease severity in children hospitalised with viral bronchiolitis.

  4. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants.

    Science.gov (United States)

    Burlingham, William J; Love, Robert B; Jankowska-Gan, Ewa; Haynes, Lynn D; Xu, Qingyong; Bobadilla, Joseph L; Meyer, Keith C; Hayney, Mary S; Braun, Ruedi K; Greenspan, Daniel S; Gopalakrishnan, Bagavathi; Cai, Junchao; Brand, David D; Yoshida, Shigetoshi; Cummings, Oscar W; Wilkes, David S

    2007-11-01

    Bronchiolitis obliterans syndrome (BOS), a process of fibro-obliterative occlusion of the small airways in the transplanted lung, is the most common cause of lung transplant failure. We tested the role of cell-mediated immunity to collagen type V [col(V)] in this process. PBMC responses to col(II) and col(V) were monitored prospectively over a 7-year period. PBMCs from lung transplant recipients, but not from healthy controls or col(IV)-reactive Goodpasture's syndrome patients after renal transplant, were frequently col(V) reactive. Col(V)-specific responses were dependent on both CD4+ T cells and monocytes and required both IL-17 and the monokines TNF-alpha and IL-1beta. Strong col(V)-specific responses were associated with substantially increased incidence and severity of BOS. Incidences of acute rejection, HLA-DR mismatched transplants, and induction of HLA-specific antibodies in the transplant recipient were not as strongly associated with a risk of BOS. These data suggest that while alloimmunity initiates lung transplant rejection, de novo autoimmunity mediated by col(V)-specific Th17 cells and monocyte/macrophage accessory cells ultimately causes progressive airway obliteration. PMID:17965778

  5. Impact on parents of bronchiolitis hospitalization of full-term, preterm and congenital heart disease infants

    Directory of Open Access Journals (Sweden)

    Lapillonne Alexandre

    2012-10-01

    Full Text Available Abstract Background The objective of this work was to explore the impact on parents of the bronchiolitis hospitalization of their infant using the Impact of Bronchiolitis Hospitalization Questionnaire (IBHQ©. Methods Four hundred sixty-three infants aged less than 1 year and hospitalized for bronchiolitis were included in a French observational study during the 2008–2009 season. Parents were asked to complete the IBHQ at hospital discharge and 3 months later. IBHQ scores, ranging from 0 (no impact to 100 (highest impact, were compared according to gestational age (full-term, 33–36 wGA, ≤ 32 wGA and the presence of congenital heart disease (CHD. The potential drivers of impact were explored using multivariate linear regressions. Results The study included 332 full-terms, 71 infants born at 33–36 wGA, and 60 at ≤ 32 wGA; 28 infants had a CHD. At hospital discharge, 9 of the 12 IBHQ mean scores were above 40, indicating a marked impact on parents. Three months later, all mean scores were lower but 5 were still greater than 40. At discharge, the length of hospitalization had a significant effect on IBHQ worries and distress, fear for future, guilt and impact on daily organization scores (p Conclusions Bronchiolitis hospitalization has conspicuous emotional, physical and organizational consequences on parents and siblings, which persist 3 months after hospital discharge. The main drivers of the impact were length of hospital stay and parents’ educational level, while infants’ gestational age or the presence of a CHD had little influence.

  6. Mechanisms underlying epithelium-dependent relaxation in rat bronchioles

    DEFF Research Database (Denmark)

    Kroigaard, Christel; Dalsgaard, Thomas; Simonsen, Ulf

    2010-01-01

    This study investigated the mechanisms underlying epithelium-derived hyperpolarizing factor (EpDHF)-type relaxation in rat bronchioles. Immunohistochemistry was performed, and rat bronchioles and pulmonary arteries were mounted in microvascular myographs for functional studies. An opener of small...... (SK(Ca)) and intermediate (IK(Ca))-conductance calcium-activated potassium channels, NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) was used to induce EpDHF-type relaxation. IK(Ca) and SK(Ca)3 positive immunoreactions were observed mainly in the epithelium and endothelium of bronchioles and arteries......, respectively. In 5-hydroxytryptamine (1 microM)-contracted bronchioles (828 +/- 20 microm, n = 84) and U46619 (0.03 microM)-contracted arteries (720 +/- 24 microm, n = 68), NS309 (0.001-10 microM) induced concentration-dependent relaxations that were reduced by epithelium/endothelium removal and by blocking IK...

  7. Management of acute viral bronchiolitis in children: Evidence beyond guidelines.

    Science.gov (United States)

    Iqbal, Shaikh Mohammed

    2012-01-01

    Acute viral bronchiolitis is one of the leading causes of worldwide admission of children under 2 years of age during winter months. There is a lack of consensus regarding the clinical definition of acute viral bronchiolitis in children and hence the management varies across the globe. The purpose of this article is to review the epidemiology, etiology, risk factors, pathophysiology, clinical presentation, assessment and management of children with respiratory syncytial virus (RSV) bronchiolitis. The available evidence in the worldwide literature suggests that supportive and symptomatic management is still the mainstay of management in this condition. The key to reducing the morbidity and mortality in children with RSV bronchiolitis is through prevention of infection through immunoprophylaxis especially in high-risk children.

  8. Advances in the treatment and prevention of severe viral bronchiolitis.

    Science.gov (United States)

    Domachowske, Joseph B; Rosenberg, Helene F

    2005-01-01

    Viral bronchiolitis continues to be a major public health problem. Prevention of severe RSV-associated bronchiolitis has been achieved in high-risk infants by passive administration of the humanized monoclonal anti-RSV-F antibody, palivizumab. Development of more potent anti-RSV neutralizing antibodies is underway, and vaccine development continues to progress. Supportive therapy is the mainstay for the treatment of established infection while new antiviral and anti-inflammatory strategies are being explored in preclinical trials.

  9. CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.

    Science.gov (United States)

    Sinha, Ian P; McBride, Antonia K S; Smith, Rachel; Fernandes, Ricardo M

    2015-09-01

    Severe respiratory failure develops in some infants with bronchiolitis because of a complex pathophysiologic process involving increased airways resistance, alveolar atelectasis, muscle fatigue, and hypoxemia due to mismatch between ventilation and perfusion. Nasal CPAP and high-flow nasal cannula (HFNC) oxygen may improve the work of breathing and oxygenation. Although the mechanisms behind these noninvasive modalities of respiratory support are not well understood, they may help infants by way of distending pressure and delivery of high concentrations of warmed and humidified oxygen. Observational studies of varying quality have suggested that CPAP and HFNC may confer direct physiologic benefits to infants with bronchiolitis and that their use has reduced the need for intubation. No trials to our knowledge, however, have compared CPAP with HFNC in bronchiolitis. Two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Two trials evaluated HFNC in bronchiolitis (one comparing it with headbox oxygen, the other with nebulized hypertonic saline), with the results not seeming to suggest important clinical or physiologic benefits. In this article, we review the pathophysiology of respiratory failure in bronchiolitis, discuss these trials in detail, and consider how future research studies may be designed to best evaluate CPAP and HFNC in bronchiolitis. PMID:25836649

  10. CPAP and High-Flow Nasal Cannula Oxygen in Bronchiolitis.

    Science.gov (United States)

    Sinha, Ian P; McBride, Antonia K S; Smith, Rachel; Fernandes, Ricardo M

    2015-09-01

    Severe respiratory failure develops in some infants with bronchiolitis because of a complex pathophysiologic process involving increased airways resistance, alveolar atelectasis, muscle fatigue, and hypoxemia due to mismatch between ventilation and perfusion. Nasal CPAP and high-flow nasal cannula (HFNC) oxygen may improve the work of breathing and oxygenation. Although the mechanisms behind these noninvasive modalities of respiratory support are not well understood, they may help infants by way of distending pressure and delivery of high concentrations of warmed and humidified oxygen. Observational studies of varying quality have suggested that CPAP and HFNC may confer direct physiologic benefits to infants with bronchiolitis and that their use has reduced the need for intubation. No trials to our knowledge, however, have compared CPAP with HFNC in bronchiolitis. Two randomized trials compared CPAP with oxygen delivered by low-flow nasal cannula or face mask and found some improvements in blood gas results and some physiologic parameters, but these trials were unable to demonstrate a reduction in the need for intubation. Two trials evaluated HFNC in bronchiolitis (one comparing it with headbox oxygen, the other with nebulized hypertonic saline), with the results not seeming to suggest important clinical or physiologic benefits. In this article, we review the pathophysiology of respiratory failure in bronchiolitis, discuss these trials in detail, and consider how future research studies may be designed to best evaluate CPAP and HFNC in bronchiolitis.

  11. Thromboangiitis Obliterans (Buerger’s Disease—Current Practices

    Directory of Open Access Journals (Sweden)

    Abhishek Vijayakumar

    2013-01-01

    Full Text Available Thromboangiitis obliterans (TAO is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40–60% of peripheral vascular diseases. Clinical features and angiographic finding are the basis of early diagnosis of TAO. Abstinence from smoking is the only definitive treatment to prevent disease progression. Medical management in form of aspirin, pentoxyfylline, cilostazol, and verapamil increase pain-free walking distance in intermittent claudication, but long term usage fails to prevent disease progression in patients who continue to smoke. Surgical treatment in form of revascularization, lumbar sympathectomy, omentopexy, and Ilizarov techniques help reduce pain and promote healing of trophic changes. Newer treatment modalities like spinal cord stimulation, prostacyclin, bosentan, VEGF, and stem cell therapy have shown promising results. Latest treatment options include peripheral mononuclear stem cell, and adipose tissue derived mononuclear stem cells have been shown to be effective in preventing disease progression, decrease major amputation rates, and improving quality of life.

  12. Assembly of a three-dimensional multitype bronchiole coculture model using magnetic levitation.

    Science.gov (United States)

    Tseng, Hubert; Gage, Jacob A; Raphael, Robert M; Moore, Robert H; Killian, Thomas C; Grande-Allen, K Jane; Souza, Glauco R

    2013-09-01

    A longstanding goal in biomedical research has been to create organotypic cocultures that faithfully represent native tissue environments. There is presently great interest in representative culture models of the lung, which is a particularly challenging tissue to recreate in vitro. This study used magnetic levitation in conjunction with magnetic nanoparticles as a means of creating an organized three-dimensional (3D) coculture of the bronchiole that sequentially layers cells in a manner similar to native tissue architecture. The 3D coculture model was assembled from four human cell types in the bronchiole: endothelial cells, smooth muscle cells (SMCs), fibroblasts, and epithelial cells (EpiCs). This study represents the first effort to combine these particular cell types into an organized bronchiole coculture. These cell layers were first cultured in 3D by magnetic levitation, and then manipulated into contact with a custom-made magnetic pen, and again cultured for 48 h. Hematoxylin and eosin staining of the resulting coculture showed four distinct layers within the 3D coculture. Immunohistochemistry confirmed the phenotype of each of the four cell types and showed organized extracellular matrix formation, particularly, with collagen type I. Positive stains for CD31, von Willebrand factor, smooth muscle α-actin, vimentin, and fibronectin demonstrate the maintenance of the phenotype for endothelial cells, SMCs, and fibroblasts. Positive stains for mucin-5AC, cytokeratin, and E-cadherin after 7 days with and without 1% fetal bovine serum showed that EpiCs maintained the phenotype and function. This study validates magnetic levitation as a method for the rapid creation of organized 3D cocultures that maintain the phenotype and induce extracellular matrix formation. PMID:23301612

  13. Serum levels of 25(OH vitamin D and immunoglobulin E in infants with bronchiolitis

    Directory of Open Access Journals (Sweden)

    Bahaa El Din Mohamed Hassanein

    2016-06-01

    Conclusions: Serum 25(OH vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis.

  14. Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins

    DEFF Research Database (Denmark)

    Poorisrisak, Porntiva; Halkjaer, Liselotte Brydensholt; Thomsen, Simon Francis;

    2010-01-01

    Respiratory syncytial virus (RSV) bronchiolitis has been associated with later development of asthma, wheezing, abnormal pulmonary function, and sensitization. Our aim was to determine the differential effect within monozygotic (MZ) twin pairs discordant for severe RSV bronchiolitis in infancy...

  15. Association of folic acid supplementation during pregnancy and infant bronchiolitis.

    Science.gov (United States)

    Veeranki, Sreenivas P; Gebretsadik, Tebeb; Dorris, Stacy L; Mitchel, Edward F; Hartert, Tina V; Cooper, William O; Tylavsky, Frances A; Dupont, William; Hartman, Terryl J; Carroll, Kecia N

    2014-04-15

    Viral bronchiolitis affects 20%-30% of infants; because there is no known effective treatment, it is important to identify risk factors that contribute to its pathogenesis. Although adequate folate intake during the periconceptional period prevents neural tube defects, animal data suggest that higher supplementation may be a risk factor for child respiratory diseases. Using a population-based retrospective cohort of 167,333 women and infants, born in 1995-2007 and enrolled in the Tennessee Medicaid program, we investigated the association between the filling of folic acid-containing prescriptions and infant bronchiolitis. We categorized women into the following 4 groups in relation to the first trimester: "none" (no prescription filled), "first trimester only," "after first trimester," and "both" (prescriptions filled both during and after the first trimester). Overall, 21% of infants had a bronchiolitis diagnosis, and 5% were hospitalized. Most women filled their first prescriptions after the fifth to sixth weeks of pregnancy, and most prescriptions contained 1,000 µg of folic acid. Compared with infants born to women in the "none" group, infants born to women in the "first trimester only" group had higher relative odds of bronchiolitis diagnosis (adjusted odds ratio = 1.17, 95% confidence interval: 1.11, 1.22) and greater severity (adjusted odds ratio = 1.16, 95% confidence interval: 1.11, 1.22). This study's findings contribute to an understanding of the implications of prenatal nutritional supplement recommendations for infant bronchiolitis.

  16. Multiple complications due to osteoradionecrosis in a patient with thromboangiitis obliterans.

    NARCIS (Netherlands)

    Barkhuysen, R.; Janssens, G.O.; Wilde, P.C.M. de; Merkx, M.A.W.

    2007-01-01

    A case is presented of a patient with thromboangiitis obliterans (TAO) who developed severe necrosis of the intraoral soft tissues and maxillary and mandibular bone after radiotherapy for a cT2N0M0 squamous cell carcinoma of the soft palate. Multiple surgical procedures including partial resection o

  17. Mycoplasma Pneumoniae and Chlamydophila pneumoniae in hospitalized children with bronchiolitis.

    Science.gov (United States)

    Zirakishvili, D; Chkhaidze, I; Barnabishvili, N

    2015-03-01

    Bronchiolitis is an acute lower respiratory tract infection in early childhood caused mainly by different viruses. Etiology of bronchiolitis have been studied in different environments and populations. Respiratory syncytial virus (RSV), human Metapneumovirus (hMPV), human Bocavirus (hBoV), human Rhinoviruses (hRV) have consistently been shown to predominate. Few studies however have attempted to determine whether other pathogens, particularly Mycoplasma Pneumoniae (MP) and Chlamydophila pneumoniae (CP), are associated with bronchiolitis in children under 2 years of age. The aim of this study was to determine the prevalence and clinical features of MP and CP in children under the age of 2 years presenting to the Iashvili Central Children Hospital in Tbilisi with various severities and clinical manifestations of bronchiolitis. Acute and convalescent serum samples were tested by ELISA for IgM and IgG antibodies to RSV, CP and MP.37 children under two years of age were studied. In 19 patients out of 37 (51.35%) etiological diagnosis were established and in 18 patients (48.65%) no pathogens were found. 11 patients (29.72%) had either CP or MP and 8 patients (21.62%) had RSV. Children infected with CP and MP had less severe bronchiolitis than those infected with RSV. Co-infection was not associated with disease severity. There were no statistically significant differences between groups with respect to length of hospital stay. Our study underlines the importance of atypical bacterial pathogens in acute bronchiolitis in children under 2 years and highlights the complex epidemiology and clinical features of these pathogens in this age group.

  18. Obliterative bronchiolitis due to Mycoplasma pneumoniae infection in a child

    International Nuclear Information System (INIS)

    A six-year-old girl presented with Mycoplasma pneumoniae involving the right upper and lower lobes. She made a slow but complete recovery with resolution of the radiological changes. She represented 5 years later with a productive cough, recurrent wheezing and physical and radiological signs suggestive of obliterative bronchiolitis. This diagnosis was confirmed by ventilation - perfusion (dV/dt/dQ/dt) lung scan, and bronchography. The case highlights the value of dV/dt/dQ/dt scanning in the diagnosis of obliterative bronchiolitis and confirms the previous reports that mycoplasma infections are not always benign. (orig.)

  19. Investigation of the Etiology of Anemia in Thromboangiitis Obliterans.

    Science.gov (United States)

    Akbarin, Mohammad Mehdi; Ravari, Hassan; Rajabnejad, Ataollah; Valizadeh, Narges; Fazeli, Bahare

    2016-09-01

    During a review of patients admitted with thromboangiitis obliterans (TAO), there was evidence of normochromic normocytic anemia and abrupt changes in hemoglobin (Hgb) levels in patients with several hospital admissions. Therefore, the evidence of hemolytic anemia was evaluated based on 37 banked plasma samples taken from Caucasian male TAO patients during disease exacerbation between 2012 and 2014. The patients' hospital records, including clinical manifestations and complete blood count, were evaluated. The following tests were performed on all samples: indirect antiglobulin test (IAT), C-reactive protein (CRP), high-sensitivity CRP (hsCRP), lactate dehydrogenase (LDH), haptoglobin, indirect bilirubin, d-aspartate aminotransferase (AST), and d-alanine aminotransferase (ALT). The mean age of the patients was 40 ± 7 years. Two patients underwent below-knee amputation. The mean hospital-documented Hgb of the patients was 12.9 ± 2.6 g/dL. CRP and IAT were positive in 75.6 and 70.2% of the samples, respectively. The tests and corresponding results were as follows: hsCRP, 14.07 ± 2.37 µg/mL; LDH, 2,552 ± 315 u/L; haptoglobin, 2.27 ± 1.1 g/L; indirect bilirubin, 0.09 ± 0.04 mg/dL; AST, 67 ± 7 u/L; and ALT, 26 ± 3 u/L. There was a significant inverse correlation between hsCRP and hospital-documented Hgb level (p = 0.03). Anemia with the positive IAT in most of the samples, high LDH and AST, and normal ALT are suggestive of hemolytic anemia. Normal indirect bilirubin is consistent with intravascular hemolysis. The positive CRP and elevated haptoglobin levels could be due to systemic inflammation in TAO. However, it is not known if an autoantigen or an infectious antigen is responsible for TAO systemic inflammation and induction hemolytic anemia. As such, the underlying mechanism of anemia in TAO could be part of the footprint of its main etiology. PMID:27574381

  20. Mechanical ventilation drives inflammation in severe viral bronchiolitis.

    Directory of Open Access Journals (Sweden)

    Marije P Hennus

    Full Text Available INTRODUCTION: Respiratory insufficiency due to severe respiratory syncytial virus (RSV infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels of inflammatory mediators in airways of mechanically ventilated children compared to spontaneous breathing children with viral bronchiolitis. In this prospective observational multi-center study we aimed to investigate whether this increase was related to disease severity or caused by mechanical ventilation. MATERIALS AND METHODS: Nasopharyngeal aspirates were collected <1 hour before intubation and 24 hours later in RSV bronchiolitis patients with respiratory failure (n = 18 and non-ventilated RSV bronchiolitis controls (n = 18. Concentrations of the following cytokines were measured: interleukin (IL-1α, IL-1β, IL-6, monocyte chemotactic protein (MCP-1 and macrophage inflammatory protein (MIP-1α. RESULTS: Baseline cytokine levels were comparable between ventilated and non-ventilated infants. After 24 hours of mechanical ventilation mean cytokine levels, except for MIP-1α, were elevated compared to non-ventilated infected controls: IL-1α (159 versus 4 pg/ml, p<0.01, IL-1β (1068 versus 99 pg/ml, p<0.01, IL-6 (2343 versus 958 pg/ml, p<0.05 and MCP-1 (174 versus 26 pg/ml, p<0.05. CONCLUSIONS: Using pre- and post-intubation observations, this study suggests that endotracheal intubation and subsequent mechanical ventilation cause a robust pulmonary inflammation in infants with RSV bronchiolitis.

  1. Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants

    DEFF Research Database (Denmark)

    Chawes, Bo L K; Poorisrisak, Porntiva; Johnston, Sebastian L;

    2012-01-01

    Respiratory syncytial virus and other respiratory tract viruses lead to common colds in most infants, whereas a minority develop acute severe bronchiolitis often requiring hospitalization. We hypothesized that such an excessive response to respiratory tract viral infection is caused by host factors...

  2. Chest physical therapy in acute viral bronchiolitis: an updated review.

    Science.gov (United States)

    Postiaux, Guy; Zwaenepoel, Bruno; Louis, Jacques

    2013-09-01

    We describe the various therapies for infant acute viral bronchiolitis and the contradictory results obtained with chest physical therapy. The treatment target is bronchial obstruction, which is a multifactorial phenomenon that includes edema, bronchoconstriction, and increased mucus production, with a clinical grading defined as severe, moderate, or mild. Chest physical therapy is revisited in its various modalities, according to preliminary scoring of the disease.

  3. Organizing pneumonia after stereotactic ablative radiotherapy of the lung

    International Nuclear Information System (INIS)

    Organizing pneumonia (OP), so called bronchiolitis obliterans organizing pneumonia after postoperative irradiation for breast cancer has been often reported. There is little information about OP after other radiation modalities. This cohort study investigated the clinical features and risk factors of OP after stereotactic ablative radiotherapy of the lung (SABR). Patients undergoing SABR between 2004 and 2010 in two institutions were investigated. Blood test and chest computed tomography were performed at intervals of 1 to 3 months after SABR. The criteria for diagnosing OP were: 1) mixture of patchy and ground-glass opacity, 2) general and/or respiratory symptoms lasting for at least 2 weeks, 3) radiographic lesion in the lung volume receiving < 0.5 Gy, and 4) no evidence of a specific cause. Among 189 patients (164 with stage I lung cancer and 25 with single lung metastasis) analyzed, nine developed OP. The incidence at 2 years was 5.2% (95% confidence interval; 2.6-9.3%). Dyspnea were observed in all patients. Four had fever. These symptoms and pulmonary infiltration rapidly improved after corticosteroid therapy. Eight patients had presented with symptomatic radiation pneumonitis (RP) around the tumor 2 to 7 months before OP. The prior RP history was strongly associated with OP (hazard ratio 61.7; p = 0.0028) in multivariate analysis. This is the first report on OP after SABR. The incidence appeared to be relatively high. The symptoms were sometimes severe, but corticosteroid therapy was effective. When patients after SABR present with unusual pneumonia, OP should be considered as a differential diagnosis, especially in patients with prior symptomatic RP

  4. Organizing pneumonia after stereotactic ablative radiotherapy of the lung

    Directory of Open Access Journals (Sweden)

    Murai Taro

    2012-08-01

    Full Text Available Abstract Background Organizing pneumonia (OP, so called bronchiolitis obliterans organizing pneumonia after postoperative irradiation for breast cancer has been often reported. There is little information about OP after other radiation modalities. This cohort study investigated the clinical features and risk factors of OP after stereotactic ablative radiotherapy of the lung (SABR. Methods Patients undergoing SABR between 2004 and 2010 in two institutions were investigated. Blood test and chest computed tomography were performed at intervals of 1 to 3 months after SABR. The criteria for diagnosing OP were: 1 mixture of patchy and ground-glass opacity, 2 general and/or respiratory symptoms lasting for at least 2 weeks, 3 radiographic lesion in the lung volume receiving  Results Among 189 patients (164 with stage I lung cancer and 25 with single lung metastasis analyzed, nine developed OP. The incidence at 2 years was 5.2% (95% confidence interval; 2.6-9.3%. Dyspnea were observed in all patients. Four had fever. These symptoms and pulmonary infiltration rapidly improved after corticosteroid therapy. Eight patients had presented with symptomatic radiation pneumonitis (RP around the tumor 2 to 7 months before OP. The prior RP history was strongly associated with OP (hazard ratio 61.7; p = 0.0028 in multivariate analysis. Conclusions This is the first report on OP after SABR. The incidence appeared to be relatively high. The symptoms were sometimes severe, but corticosteroid therapy was effective. When patients after SABR present with unusual pneumonia, OP should be considered as a differential diagnosis, especially in patients with prior symptomatic RP.

  5. Acute viral bronchiolitis in South Africa: Diagnostic flow.

    Science.gov (United States)

    White, D A; Zar, H J; Madhi, S A; Jeena, P; Morrow, B; Masekela, R; Risenga, S; Green, R

    2016-04-01

    Bronchiolitis may be diagnosed on the basis of clinical signs and symptoms. In a young child, the diagnosis can be made on the clinical pattern of wheezing and hyperinflation. Clinical symptoms and signs typically start with an upper respiratory prodrome, including rhinorrhoea, low-grade fever, cough and poor feeding, followed 1 - 2 days later by tachypnoea, hyperinflation and wheeze as a consequence of airway inflammation and air trapping.The illness is generally self limiting, but may become more severe and include signs such as grunting, nasal flaring, subcostal chest wall retractions and hypoxaemia. The most reliable clinical feature of bronchiolitis is hyperinflation of the chest, evident by loss of cardiacdullness on percussion, an upper border of the liver pushed down to below the 6th intercostal space, and the presence of a Hoover sign(subcostal recession, which occurs when a flattened diaphragm pulls laterally against the lower chest wall).Measurement of peripheral arterial oxygen saturation is useful to indicate the need for supplemental oxygen. A saturation of <92% at sea level and 90% inland indicates that the child has to be admitted to hospital for supplemental oxygen. Chest radiographs are generally unhelpful and not required in children with a clear clinical diagnosis of bronchiolitis.Blood tests are not needed routinely. Complete blood count tests have not been shown to be useful in diagnosing bronchiolitis or guiding its therapy. Routine measurement of C-reactive protein does not aid in management and nasopharyngeal aspirates are not usually done.Viral testing adds little to routine management. Risk factors in patients with severe bronchiolitis that require hospitalisation and may even cause death, include prematurity, congenital heart disease and congenital lung malformations.

  6. Acute viral bronchiolitis in South Africa: Diagnostic flow.

    Science.gov (United States)

    White, D A; Zar, H J; Madhi, S A; Jeena, P; Morrow, B; Masekela, R; Risenga, S; Green, R

    2016-04-01

    Bronchiolitis may be diagnosed on the basis of clinical signs and symptoms. In a young child, the diagnosis can be made on the clinical pattern of wheezing and hyperinflation. Clinical symptoms and signs typically start with an upper respiratory prodrome, including rhinorrhoea, low-grade fever, cough and poor feeding, followed 1 - 2 days later by tachypnoea, hyperinflation and wheeze as a consequence of airway inflammation and air trapping.The illness is generally self limiting, but may become more severe and include signs such as grunting, nasal flaring, subcostal chest wall retractions and hypoxaemia. The most reliable clinical feature of bronchiolitis is hyperinflation of the chest, evident by loss of cardiacdullness on percussion, an upper border of the liver pushed down to below the 6th intercostal space, and the presence of a Hoover sign(subcostal recession, which occurs when a flattened diaphragm pulls laterally against the lower chest wall).Measurement of peripheral arterial oxygen saturation is useful to indicate the need for supplemental oxygen. A saturation of <92% at sea level and 90% inland indicates that the child has to be admitted to hospital for supplemental oxygen. Chest radiographs are generally unhelpful and not required in children with a clear clinical diagnosis of bronchiolitis.Blood tests are not needed routinely. Complete blood count tests have not been shown to be useful in diagnosing bronchiolitis or guiding its therapy. Routine measurement of C-reactive protein does not aid in management and nasopharyngeal aspirates are not usually done.Viral testing adds little to routine management. Risk factors in patients with severe bronchiolitis that require hospitalisation and may even cause death, include prematurity, congenital heart disease and congenital lung malformations. PMID:27303779

  7. Asthma, atopy and lung function at 11 years of age after bronchiolitis in infancy

    OpenAIRE

    Mikalsen, Ingvild Bruun

    2014-01-01

    Background: Bronchiolitis is a frequently occurring respiratory disorder in young children, and also an established risk factor for subsequent recurrent wheeze and asthma. The association between bronchiolitis and later asthma is complex and not fully understood, and probably related to interactions between viral aetiology, various host factors and environmental mechanisms. Few long-term follow-up studies have included children hospitalized for bronchiolitis below 12 months ...

  8. Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death.

    Directory of Open Access Journals (Sweden)

    Chantel D Sloan

    Full Text Available Rates of Sudden Unexplained Infant Death (SUID, bronchiolitis, and central apnea increase in winter in temperate climates. Though associations between these three conditions are suggested, more work is required to establish if there is a causal pathway linking bronchiolitis to SUID through inducing central apnea. Utilizing a large population-based cohort of infants studied over a 20-year period (n = 834,595, from birth years 1989-2009, we analyzed ecological associations between timing of SUID cases, bronchiolitis, and apnea healthcare visits. Data were analyzed between 2013 and 2015. We used a Cox Proportional Hazards model to analyze possible interactions between maternal smoking and maternal asthma with infant bronchiolitis on time to SUID. SUID and bronchiolitis both occurred more frequently in winter. An increase in bronchiolitis clinical visits occurred within a few days prior to apnea visits. We found a temporal relationship between infant bronchiolitis and apnea. In contrast, no peak in SUID cases was seen during peaks of bronchiolitis. Among those without any bronchiolitis visits, maternal smoking was associated with an increased risk of SUID: Hazard Ratio (HR of 2.38 (95% CI: 2.11, 2.67, p-value <0.001. Maternal asthma was associated with an increased risk of SUID among infants with at least one bronchiolitis visit: HR of 2.40 (95% CI: 1.04, 5.54, p-value = 0.04. Consistent trends between bronchiolitis, apnea, and SUID were not established due to small numbers of SUID cases. However, interaction analysis revealed potential differential associations of bronchiolitis and SUID by maternal smoking, maternal asthma status.

  9. Effectiveness of Chest Physiotherapy in Infants Hospitalized with Acute Bronchiolitis: A Multicenter, Randomized, Controlled Trial

    OpenAIRE

    Gajdos, Vincent; Katsahian, Sandrine; Beydon, Nicole; Abadie, Véronique; de Pontual, Loïc; Larrar, Sophie; Epaud, Ralph; Chevallier, Bertrand; Bailleux, Sylvain; Mollet-Boudjemline, Alix; Bouyer, Jean; Chevret, Sylvie; Labrune, Philippe

    2010-01-01

    Editors' Summary Background Bronchiolitis, which is usually caused by the respiratory syncytial virus (RSV), is the commonest infection of the lower respiratory tract (the lungs and the passages through which air enters the lungs) in infants. A third of all children have bronchiolitis during their first year of life. The illness begins with stuffiness, a runny nose, a mild cough, and mild fever. Then, as the smallest airways in the lung (the bronchioles) become inflamed (swell) and blocked wi...

  10. Granulomatous Bronchiolitis with Necrobiotic Pulmonary Nodules in Chrohn's Disease

    Directory of Open Access Journals (Sweden)

    Hugh J Freeman

    2004-01-01

    Full Text Available A 37-year-old man with extensive Crohn's disease of the stomach, small and large intestine for almost a decade developed respiratory symptoms and radiological findings suggestive of pneumonia that failed to resolve with antibiotic treatment. Computed tomography scanning of his lungs showed extensive changes with cavitated parenchymal nodules. Histological evaluation of an open lung biopsy showed granulomatous bronchiolitis and pulmonary necrobiosis. Treatment with steroids and immunosuppression resulted in complete resolution of his clinical symptoms of pneumonia and abnormal computed tomography imaging changes. Granulomatous bronchiolitis and necrobiotic nodules may be a manifestation of Crohn's disease in the absence of microbial agents, including mycobacteria or fungal agents. While a multiplicity of complex pulmonary changes may occur in Crohn's disease, their clinical recognition and precise pathological definition may be particularly important if treatment with a biological agent, such as infliximab, is being considered.

  11. Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial.

    Science.gov (United States)

    Wang, E E; Milner, R; Allen, U; Maj, H

    1992-01-01

    A randomised double blind trial was conducted to determine the efficacy of inhaled bronchodilators, salbutamol and ipratropium bromide, compared with placebo in the treatment of bronchiolitis. Patients, who were 2 months to 2 years of age and without underlying cardiac or pulmonary disease, received drug 1 (salbutamol or saline placebo) followed one hour later by drug 2 (ipratropium bromide or placebo). Both agents were administered every four hours. The patients were allocated to one of four groups according to a factorial design. The four groups were similar in demographic characteristics, initial oxygenation, and clinical score. The change in oxygen saturation of recipients of both agents was significantly better than that of recipients of salbutamol alone or ipratropium bromide alone. This change, however, was not statistically different from that of the control group. No difference was observed in the clinical score or hospital duration. Inhaled bronchodilators did not improve the condition of hospitalised mild bronchiolitis. PMID:1533504

  12. Types of Childhood Interstitial Lung Disease

    Science.gov (United States)

    ... or postinfectious disease ( bronchiolitis obliterans) Eosinophilic pneumonia Pulmonary alveolar proteinosis Pulmonary infiltrates with eosinophilia Pulmonary lymphatic disorders (lymphangiomatosis, ...

  13. Herpes simplex virus bronchiolitis in a cannabis user

    Directory of Open Access Journals (Sweden)

    Daniel H. Libraty

    2014-01-01

    Full Text Available Herpes simplex virus (HSV lower respiratory tract infections in adults are uncommon. We present a case of HSV bronchiolitis and pneumonitis in an immunocompetent individual, likely linked to chronic habitual marijuana use and a herpetic orolabial ulcer. The case serves as a reminder to consider HSV as a potential unusual cause of lower respiratory tract infection/inflammation in individuals with chronic habitual marijuana use.

  14. Current treatment for acute viral bronchiolitis in infants.

    Science.gov (United States)

    Martinón-Torres, Federico

    2003-08-01

    This paper provides an update and critical review of available data on the treatment of acute viral bronchiolitis in previously healthy infants, with special focus on new or promising therapies. The main potential benefits of medical assistance in these patients reside in the careful monitoring of their clinical status, the maintenance of adequate hydration and oxygenation, the preservation of the airway opened and cleared of secretions and the option to perform parental education. There is no convincing evidence that any other form of therapy will reliably provide beneficial effects in infants with bronchiolitis and currently, any treatment beyond supportive care should be prescribed on a case-by-case basis with watchful appraisal of its effects. Therapies such as ribavirin, IFN, vitamin A, antibiotics, mist therapy or anticholinergics, have not demonstrated any measurable clinical effect. Several studies and meta-analyses with beta(2)-agonists and corticosteroids have failed to show any benefit of significant extent, however, physicians keep favouring their use. Presently, adrenaline has received rather consistent support from clinical trials but it is not yet widely prescribed. There are other therapeutic strategies, for instance, heliox, hypertonic saline, noninvasive ventilation, physical therapy techniques, thickened feeds or palivizumab that have shown promising potential benefits, but evidence supporting its use is still limited and further studies should be warranted. In the meantime, infants with acute viral bronchiolitis should be treated following evidence-based clinical practice guidelines, keeping the patient central in the process and being sensitive to social, cultural and familiar influences on their treatment strategy.

  15. High Concentrations of Amniotic Fluid Proinflammatory Cytokines in Healthy Neonates Are Associated With Low Risk of Respiratory Syncytial Virus Bronchiolitis

    NARCIS (Netherlands)

    Houben, Michiel L.; Rovers, Maroeska M.; Wilbrink, Berry; Belderbos, Mirjam E.; Bloemen-Carlier, Eltje M.; Visser, Gerard H. A.; Kimpen, Jan L. L.; Bont, Louis

    2012-01-01

    Background: The burden of respiratory syncytial virus (RSV) bronchiolitis in individual children and their families, the medical system and society is considerable. Mechanisms underlying RSV bronchiolitis in healthy term infants are largely unknown. Sterile intraamniotic inflammation and chorioamnio

  16. [Correction of dyslipidemia in patients with arteriosclerosis obliterans as a method for improving the results of endovascular angioplasty].

    Science.gov (United States)

    Petukhov, V A; Seitmykhamedov, M D; Dibirov, A D; Dubovik, S G; Sergeeva, N A; Prokubovskiĭ, V I

    1992-01-01

    The authors analyse the results of endovascular angioplasty of the pelvic and lower limb arteries in 147 patients of various age suffering from arteriosclerosis obliterans. It was found that the results of endovascular angioplasty depended on the state of the lipid balance. The necessity for correcting the shifts in the lipid metabolism is shown. The article evaluates the results of dyslipidemia correction by dietotherapy, pharmacotherapy, and operation for partial ilio-shunting in patients with arteriosclerosis obliterans of the pelvic and lower limb arteries. The efficacy of the listed methods of treatment are analysed according to the severity of dyslipidemia. PMID:1457133

  17. T cell subset analysis in peripheral blood of children with RSV bronchiolitis

    NARCIS (Netherlands)

    De Weerd, W; Twilhaar, WN; Kimpen, JLL

    1998-01-01

    Respiratory syncytial virus (RSV) bronchiolitis is partially an immune-mediated disease in which RSV-specific T cells play a predominant role. The peripheral blood T cell response was studied in patients with RSV bronchiolitis in order to detect evidence for T cell redistribution during natural RSV

  18. CT findings of respiratory bronchiolitis caused by cigarette smoking

    Energy Technology Data Exchange (ETDEWEB)

    Katagiri, Siro; Osima, K.; Kim, S. [Chiba Tokusyukai Hospital, Funabashi (Japan)

    1998-07-01

    CT scans were performed in 11 cases of respiratory bronchiolitis caused by cigarette smoking. Characteristics of CT findings were as follows: Remarkable visualization of the branching in peripheral bronchi within secondary lobules, multiple ground-glass opacities of centrilobular or lobular size adjacent to the above mentioned bronchial branching, thickening of the bronchial wall without dilatation, and no or minimal centrilobular emphysema. These characteristic CT findings were observed in all of 11 cases, who are current smokers, and never observed in non-smokers, ex-smokers and patients with apparent centrilobular emphysema. (author)

  19. Preliminary clinical application of SilverHawk directional atherectomy device in arteriosclerosis obliterans of lower extremity

    International Nuclear Information System (INIS)

    Objective: To evaluate the clinical efficiency and security of SilverHawk directional atherectomy device in treating arteriosclerosis obliterans of lower extremity. Methods: Seven patients with lower extremity ischemia were treated with SilverHawk directional atherectomy. The lesions length varied from 1.8 to 14.5 cm. Clinical symptoms (Fontaine classification) included 4 cases of grade Ⅱ b, I case of grade Ⅲ, 2 cases of grade Ⅳ. The ABI varied from 0.28 to 0.65. Patency was evaluated with color duplex sonography or CTA besides clinical examination during follow-up. Results: Seven occlusive lesions were recanalizated successfully. The technical success (residual stenosis < 30%) rate was 100%. Clinical symptoms were obviously improved or disappeared. The ABI varied from 0.82 to 1.18 (P=0.002), and Fontaine classification included 6 cases of Ⅰ; 1 case of Ⅱ a. Patency rate was 100% and the ABI varied from 0.75 to 1.14 (P=0.938). Fontaine classifications keep consistent 1-6 months after operation. Conclusion: SilverHawk directional atherectomy was a safe and effective way for treatment of lower arteriosclerosis obliteran. (authors)

  20. HRCT findings of chest complications in patients with leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Nobuyuki; Matsumoto, Tsuneo; Miura, Gouji; Emoto, Takuya; Matsunaga, Naofumi [Department of Radiology, Yamaguchi University School of Medicine (Japan)

    2002-06-01

    High-resolution CT (HRCT) findings of several chest complications occurring in leukemic patients were reviewed. Although most entities show non-specific HRCT findings including ground-glass opacity and air-space consolidation, characteristic findings are observed in several pulmonary complications including Pneumocystis carinii pneumonia, fungal infections, miliary tuberculosis, leukemic infiltration, pulmonary edema, bronchiolitis obliterans, and bronchiolitis obliterans organizing pneumonia. A combination of these characteristic HRCT findings and the information obtained from the clinical setting may help in achieving a correct diagnosis of chest complications occurring in leukemic patients. (orig.)

  1. Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing

    Directory of Open Access Journals (Sweden)

    Kimpen Jan LL

    2002-06-01

    Full Text Available Abstract Respiratory syncytial virus (RSV is the primary cause of hospitalization for acute respiratory tract illness in general and specifically for bronchiolitis in young children. The link between RSV bronchiolitis and reactive airway disease is not completely understood, even though RSV bronchiolitis is frequently followed by recurrent episodes of wheezing. Therapy with ribavirin does not appear to significantly reduce long-term respiratory outcome of RSV lower respiratory tract infection, and corticosteroid or bronchodilator therapy may possibly improve outcomes only on a short-term basis. No vaccine against RSV is yet available. It is not known whether prophylaxis with RSV intravenous immune globulin or palivizumab can reduce postbronchiolitic wheezing.

  2. Validation of a pediatric caregiver diary to measure symptoms of postacute respiratory syncytial virus bronchiolitis

    DEFF Research Database (Denmark)

    Santanello, Nancy C; Norquist, Josephine M; Nelsen, Linda M;

    2005-01-01

    Acute respiratory syncytial virus (RSV)-induced bronchiolitis is often associated with continuing respiratory symptoms following hospitalization. To date, there is no validated objective measure to evaluate symptoms of RSV-induced bronchiolitis. We report on the reliability, validity......, and responsiveness of the bronchiolitis caregiver diary (BCD) of symptoms and healthcare utilization associated with postacute RSV. The BCD measures four symptoms (daytime cough, wheeze, trouble breathing, and nighttime cough), healthcare utilization, and rescue medication for worsening of lung symptoms. Data from......-group differences were statistically significant in the appropriate direction. Responsiveness analyses indicated moderate effect sizes for percentage of SFD. In conclusion, the BCD provides a valid, reliable, and responsive tool for the assessment of symptoms of postacute RSV-induced bronchiolitis, capable...

  3. Exhaled nitric oxide is related to atopy, but not asthma in adolescents with bronchiolitis in infancy

    OpenAIRE

    Mikalsen, Ingvild Bruun; Halvorsen, Thomas; Øymar, Knut

    2013-01-01

    Background: The fraction of exhaled nitric oxide (FeNO) has been suggested as a non-invasive marker of eosinophilic inflammation in asthma, but lately rather as a biomarker of atopy than of asthma itself. Asthma after bronchiolitis is common up to early adolescence, but the inflammation and pathophysiology may differ from other phenotypes of childhood asthma. We aimed to assess if FeNO was different in children with former hospitalization for bronchiolitis and a control group, and...

  4. A Case–Crossover Study of Wintertime Ambient Air Pollution and Infant Bronchiolitis

    OpenAIRE

    Karr, Catherine; Lumley, Thomas; Shepherd, Kristen; Davis, Robert; Larson, Timothy; Ritz, Beate; Kaufman, Joel

    2005-01-01

    We examined the association of infant bronchiolitis with acute exposure to ambient air pollutants. Design We employed a time-stratified case–crossover method and based the exposure windows on a priori, biologically based hypotheses. Participants We evaluated effects in 19,901 infants in the South Coast Air Basin of California in 1995–2000 with a hospital discharge record for bronchiolitis in the first year of life (International Classification of Diseases, 9th Revision, CM466.1). Evaluations/...

  5. Evaluation of physiological parameters before and after respiratory physiotherapy in newborns with acute viral bronchiolitis

    OpenAIRE

    S Gonçalves, Rodrigo A; Feitosa, Sérgio; de Castro Selestrin, Cláudia; Vitor E. Valenti; de Sousa, Fernando H; F Siqueira, Arnaldo A; Petenusso, Márcio; de Abreu, Luiz Carlos

    2014-01-01

    Background Acute viral bronchiolitis is a respiratory disease with high morbidity that affects newborn in the first two years of life. Its treatment with physiotherapy has been highlighted as an important tool, however, there is no consensus regarding its effects on patients improvement. We aimed to evaluate the physiological parameters before and after the procedure respiratory therapy in newborn with acute viral bronchiolitis. Method This was a cross sectional observational study in 30 newb...

  6. Altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection

    OpenAIRE

    Galeone Carlotta; Barbier Paolo; Gualtieri Laura; Tagliabue Claudia; Tremolati Elena; Ghiglia Silvia; Bosis Samantha; Salice Patrizia; Esposito Susanna; Marchisio Paola; Principi Nicola

    2010-01-01

    Abstract Background Although the most frequent extra-pulmonary manifestations of respiratory syncytial virus (RSV) infection involve the cardiovascular system, no data regarding heart function in infants with bronchiolitis associated with RSV infection have yet been systematically collected. The aim of this study was to verify the real frequency of heart involvement in patients with bronchiolitis associated with RSV infection, and whether infants with mild or moderate disease also risk heart ...

  7. Costs associated with infant bronchiolitis in the Baffin region of Nunavut

    OpenAIRE

    Creery, David; Iyer, Priya; Samson, Lindy; Coyle, Doug; Osborne, Geraldine; MacDonald, Alexander

    2005-01-01

    Objective. Although infants living in the north of Canada have been reported to have one of the highest rates of hospital admission for bronchiolitis in the world, the economic effects of this condition have not been reported. Passive immunization against the Respiratory Syncytial Virus, the most common causative agent of infant bronchiolitis, is available. Methods. We tabulated transportation, in-hospital care and family accommodation costs for infants of less than 12 months of age residing ...

  8. Lack of effect of zinc sulfate on wheezing after bronchiolitis in infants less than two years

    Directory of Open Access Journals (Sweden)

    R Abasi

    2014-10-01

    Full Text Available Backgrounds & aim: Wheezing after bronchiolitis is known as a risk factor for asthma. No cure or effective vaccine has been identified for such disease. The purpose of this study was to determine the effects of zinc sulfate on persistent wheezing after bronchiolitis in infants less than two years. Methods: The present randomized clinical trial study was conducted on 90 infants under two years of age suffering from the first attack with a clinical diagnosis of bronchiolitis wheezing hospitalized in Imam Sajjad Hospital, Yasuj. All infants were equally placed in test groups and control group. In addition to bronchiolitis usual treatment, test group received 20 mg of elemental zinc for seven days. Patient information including risk factors associated with wheezing and persistent wheezing were compared 48 hours and two weeks after treatment. Data were analyzed using chi-square and t tests. Results: In all 90 infants diagnosed with bronchiolitis, wheezing was observed. After 48 hours and two weeks wheezing was continued in 67 patients (74.4% and 54 patients (60% respectively Conclusion: The results showed Zinc sulfate had no effect on the improvement of wheezing after bronchiolitis.

  9. Viral bronchiolitis in children: a common condition with few therapeutic options.

    Science.gov (United States)

    Nicolai, A; Ferrara, M; Schiavariello, C; Gentile, F; Grande, M E; Alessandroni, C; Midulla, F

    2013-10-01

    Even though bronchiolitis is a disease that has been recognized for many years, there are still few therapeutic strategies beyond supportive therapies. Bronchiolitis is the most frequent cause of hospital admission in children less than 1 year of age. The incidence is estimated to be about 150° million cases a year worldwide, and 2-3% of these cases require hospitalization. It is acknowledged that viruses cause bronchiolitis, but most of the studies focus on RSV. The RSV causes a more severe form of bronchiolitis in children with risk factors including prematurity, cardiovascular disease and immunodeficiency. Other viruses involved in causing bronchiolitis include RV, hMPV, hBoV and co-infections. The RV seems to be associated with a less severe acute disease, but there is a correlation between the early infection and subsequent wheezing bronchitis and asthma in later childhood and adulthood. The supportive therapies used are intravenous fluids and oxygen supplement administered by nasal cannula or CPAP in most complicated patients. Additional pharmacological therapies include epinephrine, 3% hypertonic saline and corticosteroids. The Epinephrine seems to have the greatest short-term benefits and reduces the need of hospital admission, whereas hypertonic saline and corticosteroids seem to reduce the length of hospital stay. As bronchiolitis is such a prevalent disease in children and RV seems to play an important role, perhaps more studies should center around the RV's contribution to the initial disease and following pathology.

  10. [Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD)].

    Science.gov (United States)

    Goeckenjan, G

    2003-05-01

    Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) designates interstitial lung changes in smokers, characterized histologically by bronchiolocentric accumulation of pigmented alveolar macrophages and fibrotic or cellular inflammatory changes of pulmonary interstitium. The definition is nearly identical to that of condensate pneumopathy, smoker's pneumopathy or smoker's lung, defined by accumulation of pigmented alveolar macrophages with bland alveoloseptal or peribronchial fibrosis and cellular inflammation of the bronchial wall. In addition to respiratory bronchiolitis, which is found in nearly all smokers, RB-ILD comprises a broad spectrum of varying degrees of the interstitial reaction to the exogenous injury of inhalation smoking with gradual transition to desquamative interstitial pneumonia (DIP). In most cases RB-ILD manifestations are subclinical and detected coincidentally. Radiographic features are reticulonodular and ground glass opacities of the lung. The high resolution computed tomography reveals centrilobular nodules, ground glass opacities, thickening of bronchial walls, and in some cases a reticular pattern. Mild emphysema is frequent. Lung function analysis reveals only minor restrictive or obstructive defects in most cases, often combined with hyperinflation. CO diffusing capacity is slightly to moderately impaired. Pronounced interstitial lung diseases with serious restrictive defects and arterial hypoxemia have been reported infrequently. In differential diagnosis smoking related interstitial lung diseases (DIP, Langerhans cell histiocytosis, idiopathic pulmonary fibrosis) and other interstitial lung diseases have to be excluded. In most cases diagnosis can be achieved by bronchoalveolar lavage and transbronchial lung biopsy. In cases of pronounced interstitial lung disease or assumption of an additional interstitial lung disease besides RB-ILD a thoracoscopic or open lung biopsy can be necessary. RB-ILD has a favourable

  11. Clinical profile of bronchiolitis in infants younger than 90 days in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Syed Amir Ahmad

    2014-01-01

    Full Text Available Background: Bronchiolitis is a self-limiting disease of children caused by viral infections of the small airways with a wide spectrum of illness severity. Search of the literature reveals a need for refinement of criteria for testing for concomitant severe bacterial infections as well as appropriate therapeutic interventions for patients <90-day-old diagnosed with clinical bronchiolitis. We believe that a better understanding of the disease spectrum will help optimize health-care delivery to these patients. Aims: The aim of this study was to determine the clinical profile at presentation, disease course and outcome of bronchiolitis in <3-month-old infants who presented to our Pediatric Emergency Department (PED during one disease season. Settings: Retrospective chart review during one bronchiolitis season, from November 1, 2011 to April 20, 2012. Subjects: All <90-day-old infants presenting with clinical bronchiolitis presenting to Urban PED of a tertiary care university hospital during one bronchiolitis season. Materials and Methods: A retrospective chart review based on computer records of all emergency department visits of infants less than 90 days with a clinical diagnosis of bronchiolitis, covering the period between November 1, 2011 and April 30, 2012. Results: Out of the total of 1895 infants <90 days of age, 141 had a clinical diagnosis of bronchiolitis and 35 needed admission to hospital. Blood for culture was obtained from 47 infants, urine for culture was obtained from 46 infants and cerebrospinal fluid for culture was obtained from eight infants. One case of bacteremia was documented, but this was found to be a contaminant. No cases of meningitis occurred among these infants. However, one infant had a positive urine culture consistent with infection (Escherichia coli . Conclusion: Based on the results, it can be conclude that the risk of bacteremia or meningitis among infants <90 days of age with fever and bronchiolitis is low. The

  12. Bronchiolitis associated with Mycoplasma pneumoniae in infants in Suzhou China between 2010 and 2012.

    Science.gov (United States)

    Wang, Yuqing; Hao, Chuangli; Ji, Wei; Yan, Yongdong; Shao, Xuejun; Xu, Jun

    2015-01-19

    Viruses cause most cases of bronchiolitis in infants; consequently the importance of other agents such as Mycoplasma pneumoniae (MP) in the etiology of bronchiolitis may not be fully recognized. We investigated the prevalence and seasonal distribution of bronchiolitis caused by MP in 674 children admitted to the Children's Hospital affiliated with Soochow University from January 2010 to December 2012. The presence of MP was confirmed by real-time PCR. During the 3 years, we identified MP in 17.2% of the children with bronchiolitis. The annual MP detection rates were 16.6% in 2010, 17.8% in 2011, and 17.2% in 2012. MP was detected throughout the year, with a peak from July to September. The median age of MP-positive children was 10 months. Common clinical manifestations included cough, wheezing, and high fever. Moist and/or wheezing rales were frequent, and pulmonary interstitial infiltration was seen in 66.4% of chest X-rays. Patients with MP infection were older, were more likely to have pulmonary interstitial infiltration, and had shorter hospital stays than those with respiratory syncytial virus infection. Our study revealed MP as an important cause of bronchiolitis, with peaks of occurrence during the summer and early autumn. Pulmonary interstitial infiltrations were a common event.

  13. Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates

    DEFF Research Database (Denmark)

    Vissing, Nadja Hawwa; Chawes, Bo Lk; Bisgaard, Hans

    2013-01-01

    Rationale: The frequency of pneumonia and bronchiolitis exhibits considerable variation in otherwise healthy children, and suspected risk factors explain only a minor proportion of the variation. We hypothesized that alterations in the airway microbiome in early life may be associated with suscep......Rationale: The frequency of pneumonia and bronchiolitis exhibits considerable variation in otherwise healthy children, and suspected risk factors explain only a minor proportion of the variation. We hypothesized that alterations in the airway microbiome in early life may be associated...... with susceptibility to pneumonia and bronchiolitis in young children. Objectives: To investigate the relation between neonatal airway colonization and pneumonia and bronchiolitis during the first three years of life. Methods: Participants comprised children of the COPSAC2000 cohort; a prospective birth cohort study...... of 411 children born to asthmatic mothers. Aspirates from the hypopharynx at age four weeks were cultured for S.pneumoniae, H.influenzae, M.catarrhalis, and S.aureus. Clinical information on pneumonia and bronchiolitis within the first three years of life was prospectively collected by the research...

  14. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis

    NARCIS (Netherlands)

    van Woensel, JBM; Wolfs, TFW; vanAalderen, WMC; Brand, PLP; Kimpen, JLL

    1997-01-01

    Background - Experimental and clinical evidence suggests that respiratory syncytial virus (RSV) bronchiolitis is an immune mediated disease. Corticosteroids might therefore be effective in the treatment of RSV bronchiolitis. Methods - A randomised double blind trial was conducted in children up to t

  15. Intravenous fluids versus gastric-tube feeding in hospitalized infants with viral bronchiolitis: a randomized, prospective pilot study.

    Science.gov (United States)

    Kugelman, Amir; Raibin, Karine; Dabbah, Husein; Chistyakov, Irina; Srugo, Isaac; Even, Lea; Bzezinsky, Nurit; Riskin, Arieh

    2013-03-01

    The American Academy of Pediatrics recommends intravenous fluids for infants with bronchiolitis who are unable to sustain oral feedings. Our randomized, prospective pilot study shows that gastric tube feeding (in 31 infants) is feasible and demonstrated comparable clinical outcomes with intravenous fluids (in 20 infants) among hospitalized infants ≤6 months of age with moderate bronchiolitis.

  16. Use of flow cytometry to investigate the cytokine response pattern in infants with respiratory syncytial virus infection and bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈志敏; 杜立中; 毛建华; 汤永民

    2002-01-01

    Objective: To investigate the cytokine response pattern (IL-4/IFN-γ) in infants with RSV infections and bronchiolitis during the acute phase. Methods: Four-color flow cytometry was used to measure intracellular IL-4 and IFN-γ expressions in peripheral blood CD3+ and CD8+ lymphocytes from RSV-infected and bronchiolitis infants. Serum IL-4 and IFN-γ levels were also determined. Results: RSV-infected and bronchiolitis infants showed no statistical differences from not-RSV-infected or pneumonia infants and control in the frequency of IL-4 and IFN-γ expressions in CD3+CD8- lymphocytes, showed no obvious Th1/Th2 imbalance, while IFN-γ was expressed much more frequently in CD3+CD8+ lymphocytes. Systematically, RSV-infected and bronchiolitis infants showed much lower levels of serum IL-4 and IL-4/IFN-γ ratios and much higher serum IFN-γ levels than control. However, there were no statistical differences in the above three indices between RSV-infected and not-RSV infected infants or between bronchiolitis and pneumonia infants, except that bronchiolitis infants had a higher level of serum IFN-γ than pneumonia infants statistically. Conclusions: There is no type-2 cytokine response predominance in the acute phase of RSV infection and bronchiolitis. IL-4 production is suppressed and IFN-γ production upregulated, the latter being most prominent in bronchiolitis infants.

  17. Use of Cough and Cold Medications in Severe Bronchiolitis Before and After a Health Advisory Warning against Their Use

    Science.gov (United States)

    O’Donnell, Katherine; Mansbach, Jonathan M.; LoVecchio, Frank; Cheng, John; Piedra, Pedro A.; Clark, Sunday; Sullivan, Ashley F.; Camargo, Carlos A.

    2015-01-01

    We compared the use of cough and cold medications in two multicenter studies of young children hospitalized with bronchiolitis before and after the 2008 Food and Drug Administration cough and cold medications advisory. Although cough and cold medications use decreased after the advisory, nearly 20% of children age 12–23.9 months with severe bronchiolitis received cough and cold medications. PMID:25888349

  18. Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.

    Science.gov (United States)

    Faber, Tina E; Schuurs, Theo A; Veeger, Nic J G M; Hennus, Marije P; Bont, Louis J

    2016-08-01

    The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneumococci. In patients with viral bronchiolitis who did not receive antibiotics, pneumococcal load decreased from time of admission to discharge (n = 35, cycle threshold 23 vs. 25, P = 0.0017) and from discharge to follow-up (n = 22, cycle threshold 25 vs. 40, P = 0.003). We conclude that viral respiratory infection is negatively associated with pneumococcal colonization of the upper airways. Pediatr Pulmonol. 2016;51:863-867. © 2016 Wiley Periodicals, Inc. PMID:26859410

  19. Montelukast as an episodic modifier for acute viral bronchiolitis: a randomized trial.

    Science.gov (United States)

    Zedan, Magdy; Gamil, Nareman; El-Assmy, Mohamed; Fayez, Engy; Nasef, Nehad; Fouda, Ashraf; Settin, Ahmed

    2010-01-01

    This study was designed to evaluate the effect of once-daily montelukast therapy on the clinical progress and the cytokine profile of patients with acute viral bronchiolitis. A randomized, double-blind, placebo-controlled trial included 85 patients (mean age, 3.5 +/- 2.35 months), clinically diagnosed as first-episode acute bronchiolitis in addition to 10 healthy controls of matched age and sex. Patients were randomly assigned to receive either montelukast (4-mg sachets; n = 47) or placebo (n = 38) daily from the time of admission until discharge. The primary outcome measure was the length of hospital stay (LOS), and clinical severity scores (CSs) and changes in plasma levels of interferon gamma and interleukin-4 were secondary outcomes. LOS for the montelukast group was found to be significantly lower than that of the placebo group (p viral bronchiolitis.

  20. Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.

    Science.gov (United States)

    Faber, Tina E; Schuurs, Theo A; Veeger, Nic J G M; Hennus, Marije P; Bont, Louis J

    2016-08-01

    The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneumococci. In patients with viral bronchiolitis who did not receive antibiotics, pneumococcal load decreased from time of admission to discharge (n = 35, cycle threshold 23 vs. 25, P = 0.0017) and from discharge to follow-up (n = 22, cycle threshold 25 vs. 40, P = 0.003). We conclude that viral respiratory infection is negatively associated with pneumococcal colonization of the upper airways. Pediatr Pulmonol. 2016;51:863-867. © 2016 Wiley Periodicals, Inc.

  1. The Effects of Inhaled Steroids on Recurrent Wheeze After Acute Bronchiolitis

    Directory of Open Access Journals (Sweden)

    Patricia Green MD

    2015-07-01

    Full Text Available Background. Acute bronchiolitis infection during infancy is associated with an increased risk of asthma later in life. The objective of this study was to determine if inhaled steroids are effective in preventing the development of recurrent wheeze or asthma following acute bronchiolitis. Methods. Multiple databases and bibliographies of selected references were searched. Inclusion required (a a randomized controlled trial of inhaled steroids and control group, (b at least 2 weeks duration of therapy started during the acute phase of disease, and (c identification of the rate of recurrent wheeze or asthma at least 6 months after therapy. Results. Of 1410 studies reviewed, 8 reports were included in this meta-analysis (748 patients. The overall odds ratio for developing recurrent wheeze or asthma with treatment versus without treatment was 1.02 (95% confidence interval = 0.58-1.81. Conclusions. A course of inhaled steroids after acute bronchiolitis is not effective in preventing recurrent wheeze or asthma.

  2. Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants.

    Science.gov (United States)

    Baraldi, Eugenio; Lanari, Marcello; Manzoni, Paolo; Rossi, Giovanni A; Vandini, Silvia; Rimini, Alessandro; Romagnoli, Costantino; Colonna, Pierluigi; Biondi, Andrea; Biban, Paolo; Chiamenti, Giampietro; Bernardini, Roberto; Picca, Marina; Cappa, Marco; Magazzù, Giuseppe; Catassi, Carlo; Urbino, Antonio Francesco; Memo, Luigi; Donzelli, Gianpaolo; Minetti, Carlo; Paravati, Francesco; Di Mauro, Giuseppe; Festini, Filippo; Esposito, Susanna; Corsello, Giovanni

    2014-10-24

    Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year of age worldwide. It is usually a mild disease, but some children may develop severe symptoms, requiring hospital admission and ventilatory support in the ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases and immunodeficiency) may be predisposed to a severe form of the disease. Clinical diagnosis of bronchiolitis is manly based on medical history and physical examination (rhinorrhea, cough, crackles, wheezing and signs of respiratory distress). Etiological diagnosis, with antigen or genome detection to identify viruses involved, may have a role in reducing hospital transmission of the infection. Criteria for hospitalization include low oxygen saturation (bronchiolitis, and the mainstay of therapy is supportive care. This consists of nasal suctioning and nebulized 3% hypertonic saline, assisted feeding and hydration, humidified O2 delivery. The possible role of any pharmacological approach is still debated, and till now there is no evidence to support the use of bronchodilators, corticosteroids, chest physiotherapy, antibiotics or antivirals. Nebulized adrenaline may be sometimes useful in the emergency room. Nebulized adrenaline can be useful in the hospital setting for treatment as needed. Lacking a specific etiological treatment, prophylaxis and prevention, especially in children at high risk of severe infection, have a fundamental role. Environmental preventive measures minimize viral transmission in hospital, in the outpatient setting and at home. Pharmacological prophylaxis with palivizumab for RSV bronchiolitis is indicated in specific categories of children at risk during the epidemic period. Viral bronchiolitis, especially in the case of severe form, may correlate with an increased incidence of recurrent wheezing in pre-schooled children and with asthma at school age

  3. Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans.

    Science.gov (United States)

    He, T; Qu, B H; Wang, D L; Hu, M

    2015-06-18

    We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining). The animals were killed at various times following the operation and serum and muscle tissues were sampled. For the sham group: the endometrium was relatively intact; medial membrane and epineurium lesions were absent; and blood vessels and surrounding tissues had no inflammatory cell infiltration. For the model group: all subgroups displayed inflammation; large numbers of inflammatory cells were gathered; muscle tissue lost its normal texture and structure; and the internal elastic membrane was integrated. Compared with the preoperative status, HIF-1α expression increased significantly in all subgroups (P < 0.05); there was no change in the sham group. HIF-1α expression in each subgroup was different (F = 14.267, P < 0.05). Femoral artery injection of lauric acid can be used as a rat TO model owing to its simple application and success rate. HIF-1α expression increased in the early stage of TO and gradually decreased with the extension of ischemia time; it may play a leading role in TO development and can be used for diagnosis and cure evaluation.

  4. Clinical study of the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction

    International Nuclear Information System (INIS)

    To clarify the relationship between arteriosclerosis obliterans (ASO) and cerebral infarction (CI), brain CT was performed and the risk factors for atherosclerosis were assessed. Thirty-five male and 5 female patients with intermittent claudication and/or leg ulceration were angiographically diagnosed as having ASO. According to CT findings, these patients were divided into three groups [no low-density areas (NLDA), hemorrhage, and infarction (CI)]. CI was subdivided as lacunar, cortical, and watershed infarction. Thirteen patients were in the NLDA group and 26 in the CI group (17 lacunar, 3 cortical and 6 mixed infarcts), indicating a CI incidence of 65%. Comparing the risk factors of the CI group with those of the NLDA group, hypertension (53.8%), diabetes (34.6%), and cigarette smoking (69.2%) was often seen in the CI group, although hypercholesterolemia (53.8%) and ischemic heart disease (42.3%) was the same in both groups. Multivariate analysis revealed that smoking had the strongest effect on the occurrence of CI in ASO patients. Furthermore, the number of combined risk factors (hypertension, diabetes, smoking, hypercholesterolemia) had a significant positive correlation with cortical infarction. As to the chronological relationship between the onset of ASO and CI, CI was present in 14 of 27 ASO patients on CT when the ischemic leg symptoms appeared, while symptomatic cortical infarction preceded ASO in 5 patients. CI patients increased gradually over a decade to 26 out of 40, among whom 16 patients with lacunae had silent infarcts. These findings suggested that ASO is frequently associated with CI, not only due to atherosclerosis of the main trunks of the cerebral vessels, but also due to arteriolosclerosis of the perforating arteries. (author)

  5. Absence of Bordetella pertussis Among Infants Hospitalized for Bronchiolitis in Finland, 2008-2010.

    Science.gov (United States)

    Korppi, Matti; Kivistö, Juho; Koponen, Petri; Lehtinen, Pasi; Remes, Sami; Piippo-Savolainen, Eija; Piedra, Pedro A; Espinola, Janice A; Camargo, Carlos A; Jartti, Tuomas

    2016-02-01

    In 169 Finnish infants hospitalized for bronchiolitis at age Bordetella pertussis and 16 viruses. Respiratory viruses were detected in 89% (71% with respiratory syncytial virus), but no infant had B. pertussis. The latter finding may reflect a positive effect from the broadening of the Finnish pertussis vaccination program in 2005.

  6. Placebo-controlled trial of nebulization with adrenaline in acute bronchiolitis: a quasi-experimental study

    International Nuclear Information System (INIS)

    Background: Bronchiolitis is an acute inflammatory obstruction. of small In children that occurs In first two years of life and is by fever, rhinitis, cough, tachypnoea, expiratory wheeze and increased respiratory effort To study efficacy of nebulized adrenaline compared with placebo in acute bronchiolitis. Quasi-experimental study carried out at Department of aediatrics, King Edward Medical University/ Mayo Hospital, Lahore from October 2006 through March 2007. After consent from parents, sixty children of age between 2 months to 2 years with the first episode consistent with clinical case definition of bronchiolitis were included by using convenient sampling. clinical scoring system was used to grade the severity of disease as well as to monitor the efficacy of intervention. Those having score = 8 were randomly allocated to the two study groups. The information was recorded at 0 minute and effect of each method of treatment was followed for 90 minutes. Results: Our study population was 60 children. The mean age was 11:1:6 Months. Male to female ratio was 1.2: 1. Mean weight of the Children was 9:1:3 kg. Improvement in clinical score, oxygen saturation, and length of hospital at 0 and 90 minutes was noted in both groups but when compared with placebo, there was no Statistically significant difference. Conclusion: There is no difference in the efficacy of nebulization with adrenaline compared with placebo in the management of acute bronchiolitis. (author)

  7. Safely Discharging Infants with Bronchiolitis from an Emergency Department: A Five Step Guide for Pediatricians

    Science.gov (United States)

    Stollar, Fabiola; Gervaix, Alain; Argiroffo, Constance Barazzone

    2016-01-01

    Recent publications have established the pulse oxygen saturation (SpO2) threshold of 90% for the hospitalization and discharge of infant patients with bronchiolitis. However, there is no clear recommendation regarding the Emergency Department (ED) observation period necessary before allowing safe home discharge for patients with SpO2 above 90%-92%. Our primary aims were to evaluate the risk factors associated with delayed desaturation in infants with SpO2 ≥ 92% on arrival at the ED as well as the ED observation period necessary before allowing safe home discharge. A secondary aim was to identify the risk factors for ED readmission. Of 581 episodes of bronchiolitis in patients 6KPa) were risk factors for delayed desaturation with OR varying from 1.7 to 7.5. In patients bronchiolitis from the ED. By using the threshold of an 11 hour ED observation period for patients ≥ 3 months old and a 25 hour period for patients bronchiolitis who are at risk of delayed desaturation. PMID:27690359

  8. Acute viral bronchiolitis in South Africa: Strategies for management and prevention.

    Science.gov (United States)

    Zar, H J; Madhi, S A; White, D A; Masekela, R; Risenga, S; Lewis, H; Feldman, C; Morrow, B; Jeena, P

    2016-04-01

    Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected. Prevention of respiratory syncytial virus (RSV) disease remains a challenge. A specific RSV monoclonal antibody, palivizumab, administered as an intramuscular injection, is available for children at risk of severe bronchiolitis, including premature infants, young children with chronic lung disease, immunodeficiency, or haemodynamically significant congenital heart disease. Prophylaxis should be commenced at the start of the RSV season and given monthly during the season. The development of an RSV vaccine may offer a more effective alternative to prevent disease, for which the results of clinical trials are awaited. Education of parents or caregivers and healthcare workers about diagnostic and management strategies should include the following: bronchiolitis is caused by a virus; it is seasonal; it may start as an upper respiratory tract infection with low-grade fever; symptoms are cough and wheeze, often with fast breathing; antibiotics are generally not needed; and the condition is usually self limiting, although symptoms may occur for up to four weeks in some children.

  9. The effect of 3% and 6% hypertonic saline in viral bronchiolitis: a randomised controlled trial.

    Science.gov (United States)

    Teunissen, Jasmijn; Hochs, Anne H J; Vaessen-Verberne, Anja; Boehmer, Annemie L M; Smeets, Carien C J M; Brackel, Hein; van Gent, René; Wesseling, Judith; Logtens-Stevens, Danielle; de Moor, Ronald; Rosias, Philippe P R; Potgieter, Steph; Faber, Marianne R; Hendriks, Han J E; Janssen-Heijnen, Maryska L G; Loza, Bettina F

    2014-10-01

    Bronchiolitis is a common disorder in young children that often results in hospitalisation. Except for a possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy is available. This study investigated the efficacy of nebulised 3% and 6% hypertonic saline compared with 0.9% hypertonic saline in children hospitalised with viral bronchiolitis. In this multicentre, double-blind, randomised, controlled trial, children hospitalised with acute viral bronchiolitis were randomised to receive either nebulised 3%, 6% hypertonic saline or 0.9% normal saline during their entire hospital stay. Salbutamol was added to counteract possible bronchial constriction. The primary endpoint was the length of hospital stay. Secondary outcomes were need for supplemental oxygen and tube feeding. From the 292 children included in the study (median age 3.4 months), 247 completed the study. The median length of hospital stay did not differ between the groups: 69 h (interquartile range 57), 70 h (IQR 69) and 53 h (IQR 52), for 3% (n=84) and 6% (n=83) hypertonic saline and 0.9% (n=80) normal saline, respectively, (p=0.29). The need for supplemental oxygen or tube feeding did not differ significantly. Adverse effects were similar in the three groups. Nebulisation with hypertonic saline (3% or 6% sodium chloride) although safe, did not reduce the length of stay in hospital, duration of supplemental oxygen or tube feeding in children hospitalised with moderate-to-severe viral bronchiolitis.

  10. [What evidence for chest physiotherapy in infants hospitalized for acute viral bronchiolitis?].

    Science.gov (United States)

    Bailleux, S; Lopes, D; Geoffroy, A; Josse, N; Labrune, P; Gajdos, V

    2011-04-01

    This article updates the respiratory physiotherapy technique used in France, and the rationale for its use. This paper reports the results of a recent randomized clinical trial that did not show any efficiency of respiratory physiotherapy (using increased expiratory acceleration) in infants hospitalized for a first episode of bronchiolitis. Further trials are necessary for evaluating this technique in infants who are not hospitalized.

  11. Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergy.

    Science.gov (United States)

    Voisin, C; Sardella, A; Marcucci, F; Bernard, A

    2010-07-01

    Recent studies suggest that swimming in chlorinated pools during infancy may increase the risks of lower respiratory tract infection. The aim of the present study was to assess the influence of swimming in chlorinated pools on the risks of bronchiolitis and its late consequences. A total of 430 children (47% female; mean age 5.7 yrs) in 30 kindergartens were examined. Parents completed a questionnaire regarding the child's health history, swimming practice and potential confounders. Attendance at indoor or outdoor chlorinated pools ever before the age of 2 yrs was associated with an increased risk of bronchiolitis (OR 1.68; 95% CI 1.08-2.68; p = 0.03), which was exposure-dependent for both types of pool (p-value for trend 20 h spent in chlorinated pools during infancy. Infant swimmers who developed bronchiolitis also showed higher risks of asthma and respiratory allergies later in childhood. Swimming pool attendance during infancy is associated with a higher risk of bronchiolitis, with ensuing increased risks of asthma and allergic sensitisation. PMID:20075053

  12. Acute Bronchiolitis. Which Patients Should Be Admitted to Intensive Care Units?

    Directory of Open Access Journals (Sweden)

    Ariel Efrén Uriarte Méndez

    2014-12-01

    Full Text Available Bronchiolitis is the most common viral infection of the lower respiratory tract in childhood; it is considered the most severe respiratory condition that affects children under 2 years of age. In general, mortality from bronchiolitis is low, but it can reach up to 30% in patients at risk. Twenty children have died from this condition in the pediatric hospital of Cienfuegos in the last 30 years. Bronchiolitis-related deaths account for approximately 4 % of all deaths from 2010 to date. This fact has led to the implementation of administrative measures to reduce deaths from this cause, which have not solved the problem. The aim of this paper is to present a set of criteria for admission of bronchiolitis patients to intensive care units in order to be considered by the administrators of the institution. These criteria based on the authors’ experience and scientific evidence reflected in the literature focus on preventing overcrowding of this service with patients not showing signs of serious condition, and on the contrary, timely identifying those likely to have an unfavourable outcome.

  13. Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway

    Directory of Open Access Journals (Sweden)

    Gulbrandsen Pål

    2005-08-01

    Full Text Available Abstract Background Acute viral bronchiolitis is one of the most common causes of hospitalisation during infancy in our region with respiratory syncytial virus (RSV historically being the major causative agent. Many infants with early-life RSV bronchiolitis have sustained bronchial hyperreactivity for many years after hospitalisation and the reasons for this are probably multifactorial. The principal aim of the present study was to investigate if children hospitalised for any acute viral bronchiolitis during infancy in our region, and not only those due to RSV, had more episodes of subsequent wheezing up to age seven years and reduced lung function at that age compared to children not hospitalised for acute bronchiolitis during infancy. A secondary aim was to compare the hospitalised infants with proven RSV bronchiolitis (RS+ to the hospitalised infants with non-RSV bronchiolitis (RS- according to the same endpoints. Methods 57 infants hospitalised at least once with acute viral bronchiolitis during two consecutive winter seasons in 1993–1994 were examined at age seven years. An age-matched control group of 64 children, who had not been hospitalised for acute viral bronchiolitis during infancy, were recruited from a local primary school. Epidemiological and clinical data were collected retrospectively from hospital discharge records and through structured clinical interviews and physical examinations at the follow-up visit. Results The children hospitalised for bronchiolitis during infancy had decreased lung function, more often wheezing episodes, current medication and follow-up for asthma at age seven years than did the age matched controls. They also had lower average birth weight and more often first order family members with asthma. We did not find significant differences between the RSV+ and RSV- groups. Conclusion Children hospitalised for early-life bronchiolitis are susceptible to recurrent wheezing and reduced pulmonary function by

  14. Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis

    Directory of Open Access Journals (Sweden)

    Skjaeret Camilla

    2006-12-01

    Full Text Available Abstract Background Respiratory syncytial virus (RSV is a major cause of viral bronchiolitis in infants worldwide, and environmental, viral and host factors are all of importance for disease susceptibility and severity. To study the systemic host response to this disease we used the microarray technology to measure mRNA gene expression levels in whole blood of five male infants hospitalised with acute RSV, subtype B, bronchiolitis versus five one year old male controls exposed to RSV during infancy without bronchiolitis. The gene expression levels were further evaluated in a new experiment using quantitative real-time polymerase chain reaction (QRT-PCR both in the five infants selected for microarray and in 13 other infants hospitalised with the same disease. Results Among the 30 genes most differentially expressed by microarray nearly 50% were involved in immunological processes. We found the highly upregulated interferon, alpha-inducible protein 27 (IFI27 and the highly downregulated gene Charcot-Leyden crystal protein (CLC to be the two most differentially expressed genes in the microarray study. When performing QRT-PCR on these genes IFI27 was upregulated in all but one infant, and CLC was downregulated in all 18 infants, and similar to that given by microarray. Conclusion The gene IFI27 is upregulated and the gene CLC is downregulated in whole blood of infants hospitalised with RSV, subtype B, bronchiolitis and is not reported before. More studies are needed to elucidate the specificity of these gene expressions in association with host response to this virus in bronchiolitis of moderate severity.

  15. High rate of viral identification and coinfections in infants with acute bronchiolitis

    Directory of Open Access Journals (Sweden)

    Milena Siciliano Nascimento

    2010-01-01

    Full Text Available OBJECTIVES: To determine the viruses and risk factors associated with hospital and intensive care unit (ICU admissions in infants with acute bronchiolitis. INTRODUCTION: Bronchiolitis is a major cause of morbidity in infants. Widespread use of molecular-based methods has yielded new insights about its etiology, but the impact of viral etiologies on early outcomes is still unclear. METHODS: Seventy-seven infants with bronchiolitis who were under two years of age and visited an emergency unit were included. Using molecular-based methods, samples were tested for 12 different respiratory viruses. Logistic regression models were used to identify clinical and virological variables associated with the main endpoints: hospital admission and ICU admission. RESULTS: We identified at least one virus in 93.5% of patients, and coinfections were found in nearly 40% of patients. RSV was the most common pathogen (63.6%, followed by rhinovirus (39%. Identification of RSV was only associated with an increased risk of hospital admission in the univariate model. Younger age and enterovirus infection were associated with an increased risk of hospital admission, while atopy of a first-degree relative showed a protective effect. Prematurity was associated with an increased risk of admission to the ICU. Coinfections were not associated with worse outcomes. CONCLUSIONS: Molecular-based methods resulted in high rates of viral identification but did not change the significant role of RSV in acute bronchiolitis. Younger age and enterovirus infection were risk factors for hospital admission, while prematurity appeared to be a significant risk factor for admission to the ICU in acute viral bronchiolitis.

  16. Treatment of respiratory syncytial virus bronchiolitis : 1995 poll of members of the European Society for Paediatric Infectious Diseases

    NARCIS (Netherlands)

    Kimpen, JLL; Schaad, UB

    1997-01-01

    Background. Among the lower respiratory tract infections during infancy requiring hospitalization, respiratory syncytial virus (RSV) bronchiolitis is the most frequent disease entity. Nevertheless treatment remains controversial. Methods. A poll among the European Society for Paediatric Infectious D

  17. Use of flow cytometry to investigate the cytokine response pattern in infants with respiratory syncytial virus infection and bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective:To investigate the cytokine response pattern(IL-4/IFN-γ)in infants with RSV infections and bronchiolitis during the acute phase,Methods:Four-color flow cytometry was used to measure intracellular IL-4 and IFN-γ expressions in peripheral blood CD3+ and CD*+ lymphocytes from RSV-infected and bronchiolitis infants.Serum IL-4 and INF-γ levels were also determined.Results:RSV-infected and bronchiolitis infants showed no statistical differences from not-RSV-infected or pneumonia infants and control in the frequency of IL-4 and INF-γ levels were also determined.Results;RSV-infected and bronchiolitis infants showed no statistical differences from not-RSV-infected or pneumonia infants and control in the frequency of IL-4 and IFN-γ expressions in CD3+CD8- lymphocytes,showed no obvious Th1/Th2 imbalance,while IFN-γ was expressed much more frequently in CD3+CD*+ lymphocytes.Systematically,RSV-infected and bronchiolitis infants showed moch lower levels of serum IL-4 and IL-4/INF-γ ratios and much higher serum IFN-γ levels than control.Howerver,there were no statistical differences in the above three indices between RSV-infected and not-RSV infected infants or between bronchiolitis and pneumonia infants,except that bronchiolitis infants had a higher level of serum INF-γ than pneumonia infants statistically .Conclusions:There is no type-2 cytokine response predominance in the acute thase of RSV infection and bronchilitis.IL-4 productioin is suppressed and IFN-γ production upregulated,the latter being most prominent in bronchiolitis infants.

  18. Test de marcha de seis minutos en niños con bronquiolitis obliterante postviral: Correlación con espirometría Six minute walk test in children with post-infectious obliterans bronchiolitis: Its relation with spirometry

    OpenAIRE

    DANIEL ZENTENO A; HOMERO PUPPO G; RAMIRO GONZÁLEZ V; DOLORES PAVÓN T; ROBERTO VERA U; RODRIGO TORRES C; CHUNG KUO K; MARÍA ANGÉLICA PÉREZ H; GUIDO GIRARDI B

    2008-01-01

    la Bronquiolitis Obliterante (BO) postviral produce alteraciones en la función pulmonar que pueden repercutir en la capacidad para realizar ejercicio, la cual se puede evaluar con el test de marcha de 6 minutos (TM6). Objetivo: Estudiar con esta prueba a niños con BO postviral y determinar la relación entre variables espirométricas y los resultados del TM6. Veintisiete pacientes, se estudiaron con espirometría basal y TM6. Se relacionaron variables espirométricas con resultados del TM6: dista...

  19. Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans

    OpenAIRE

    Rita Mattiello; Javier Mallol; Gilberto Bueno Fischer; Helena Teresinha Mocelin; Belkys Rueda; Edgar Enrique Sarria

    2010-01-01

    OBJETIVO: Descrever a função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa (BOPI) e avaliar potenciais fatores de risco para pior função pulmonar. MÉTODOS: A função pulmonar de 77 participantes, com idades de 8-18 anos, foi avaliada por meio de espirometria e pletismografia. Os seguintes parâmetros foram analisados: CVF, VEF1, FEF25-75%, VEF1/CVF, VR, CPT, VR/CPT, volume de gás intratorácico e specific airway resistance (sRaw, resistência específica das vias ...

  20. Bronquiolite obliterante pós-infecciosa: aspectos clínicos e exames complementares de 48 crianças Post-infectious bronchiolitis obliterans: clinical aspects and complementary testing of 48 children

    OpenAIRE

    Rosaly Vieira dos Santos; Rosário, Nelson A.; Carlos Antônio Ried

    2004-01-01

    INTRODUÇÃO: A evolução clínica da bronquiolite obliterante pós infecciosa é variável. OBJETIVO: Verificar as características clínicas, a evolução e os exames complementares de 48 pacientes com bronquiolite obliterante (BO) pós-infecciosa. MÉTODO: Estudo observacional e retrospecitvo. O diagnóstico de bronquiolite obliterante foi baseado em critérios clínicos, tomográficos e pela exclusão de outras doenças. Avaliou-se a história prévia ao diagnóstico e exames complementares. A saturação arteri...

  1. Función pulmonar y calidad de vida en niños y adolescentes con bronquiolitis obliterante por adenovirus Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection

    OpenAIRE

    Stefhanie Nayar E; Mónica Saavedra B; Ana María Escobar C; Alberto Vidal G

    2011-01-01

    Introducción: La infección por adenovirus es una causa importante de neumonía en niños chilenos. La bronquiolitis obliterante (BOPI) es la complicación más importante. Existen pocos estudios donde evalúen la función pulmonar y la calidad de vida de los pacientes con BOPI. Objetivo: Evaluar la función pulmonar y la calidad de vida de los pacientes con BOPI y la correlación entre ambas variables. Métodos: Se incluyeron 14 niños con BOPI en elpoliclínico de la unidad de broncopulmonar de un hosp...

  2. [Nebulized hypertonic saline and acute viral bronchiolitis in infants: current aspects].

    Science.gov (United States)

    Sauvaget, E; David, M; Bresson, V; Retornaz, K; Bosdure, E; Dubus, J-C

    2012-06-01

    Acute viral bronchiolitis affects infants, is frequent, and can be severe. Its treatment is only based on symptoms. Hypertonic saline (HS) may act favorably in this situation by fighting virus-induced dehydration of the airway liquid surface. Because of an osmotic action, HS attracts the water from the epithelial cells and improves mucociliary clearance. Five double-blind placebo-controlled studies concerning hospitalized infants with acute viral bronchiolitis showed that repeated nebulizations of 3% HS induce a 20% improvement in the clinical severity score and reduced the hospital length of stay by 24h. Tolerance is excellent. On the other hand, a few questions remain unresolved: what is the optimal salt concentration? What is the recommended nebulizer? What is the best frequency for nebulizer use? Can nebulized HS be used at home? What are the results with systematic physiotherapy when HS is used?

  3. Respiratory dysfunction and proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis.

    Science.gov (United States)

    Bonville, Cynthia A; Bennett, Nicholas J; Koehnlein, Melissa; Haines, Deborah M; Ellis, John A; DelVecchio, Alfred M; Rosenberg, Helene F; Domachowske, Joseph B

    2006-05-25

    We explore relationships linking clinical symptoms, respiratory dysfunction, and local production of proinflammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis. With a reduced inoculum of this natural rodent pathogen, we observe virus clearance by day 9, while clinical symptoms and respiratory dysfunction persist through days 14 and 17 postinoculation, respectively. Via microarray and ELISA, we identify expression profiles of proinflammatory mediators MIP-1alpha, MCP-1, and MIP-2 that correlate with persistent respiratory dysfunction. MIP-1alpha is localized in bronchial epithelium, which is also the major site of PVM replication. Interferon-gamma was detected in lung tissue, but at levels that do not correlate with respiratory dysfunction. Taken together, we present a modification of our pneumovirus infection model that results in improved survival and data that stand in support of a connection between local production of specific mediators and persistent respiratory dysfunction in the setting of acute viral bronchiolitis.

  4. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease: Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy

    Directory of Open Access Journals (Sweden)

    Ignacio López de Maturana

    2013-01-01

    Full Text Available Thromboangiitis obliterans (TAO or Buerger's disease is associated with both distal ulcers in the extremities and the possibility of amputation. The only treatment that has been shown to be effective in TAO is complete abstention from smoking. In spite of this, the disease progresses in up to 30 percent of cases and finally results in limb amputation. Only a few pharmacological and surgical options are available to date to improve healing ulcers in TAO. The efficacy of prostaglandin analogues is controversial. This paper summarizes the current evidence for medical treatment with bosentan in chronic ulcers in TAO patients. These available data up to date allow us to conclude that the beneficial effects of bosentan on improving endothelial function, inflammatory processes, and selective vasodilatation of damaged vessels result in a clinical enhancement regarding healing and preventive digital ulcers in such patients. In any case, these promising findings have to be confirmed with larger randomised trials.

  5. Not all infantile respiratory distress in winter is bronchiolitis: congenital lobar emphysema

    OpenAIRE

    Taqvi, Laura; Griksaitis, Michael; Eastham, Katherine

    2011-01-01

    The authors report the case of a 4-week-old male infant presented during the winter period with respiratory distress. He had a 3 day history of cough and coryza, and a 2 day history of breathlessness and reduced feeding. He had evidence of tachypnoea, subcostal recession and hypoxia on examination. An initial diagnosis of bronchiolitis was made. The authors explore how the correct diagnosis of congenital lobar emphysema (CLE) was reached, highlighting key clinical signs and investigations. He...

  6. CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results* , **

    OpenAIRE

    Mocelin, Helena; Bueno, Gilberto; Irion, Klaus; Marchiori, Edson; Sarria, Edgar; Watte, Guilherme; Hochhegger, Bruno

    2013-01-01

    OBJECTIVE: To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB). METHODS: CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of −950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We exami...

  7. Helium-oxygen mixture does not improve gas exchange in mechanically ventilated children with bronchiolitis

    OpenAIRE

    Gross, Matthew F; Spear, Robert M.; Peterson, Bradley M

    2000-01-01

    Introduction: Heliox has been found to reduce both the arterial carbon dioxide tension (PaCO2) and work of breathing in children and adults with status asthmaticus. We hypothesized that, in mechanically ventilated children with bronchiolitis, increasing the ratio of helium:oxygen concentrations would improve both ventilation and oxygenation. Objective: To examine the effect of varying concentrations of heliox mixtures on ventilation and oxygenation in mechanically ventilated children with bro...

  8. Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis

    Directory of Open Access Journals (Sweden)

    Brody Steven L

    2010-06-01

    Full Text Available Abstract Background Viral bronchiolitis is the leading cause of hospitalization in young infants. It is associated with the development of childhood asthma and contributes to morbidity and mortality in the elderly. Currently no therapies effectively attenuate inflammation during the acute viral infection, or prevent the risk of post-viral asthma. We hypothesized that early treatment of a paramyxoviral bronchiolitis with azithromycin would attenuate acute and chronic airway inflammation. Methods Mice were inoculated with parainfluenza type 1, Sendai Virus (SeV, and treated daily with PBS or azithromycin for 7 days post-inoculation. On day 8 and 21 we assessed airway inflammation in lung tissue, and quantified immune cells and inflammatory mediators in bronchoalveolar lavage (BAL. Results Compared to treatment with PBS, azithromycin significantly attenuated post-viral weight loss. During the peak of acute inflammation (day 8, azithromycin decreased total leukocyte accumulation in the lung tissue and BAL, with the largest fold-reduction in BAL neutrophils. This decreased inflammation was independent of changes in viral load. Azithromycin significantly attenuated the concentration of BAL inflammatory mediators and enhanced resolution of chronic airway inflammation evident by decreased BAL inflammatory mediators on day 21. Conclusions In this mouse model of paramyxoviral bronchiolitis, azithromycin attenuated acute and chronic airway inflammation. These findings demonstrate anti-inflammatory effects of azithromycin that are not related to anti-viral activity. Our findings support the rationale for future prospective randomized clinical trials that will evaluate the effects of macrolides on acute viral bronchiolitis and their long-term consequences.

  9. Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlled clinical trial.

    OpenAIRE

    Maheshkumar, K B; B.P. Karunakara; Nagalli, Manjunath Mallikarjuna; Mallikarjuna, H B

    2013-01-01

    ABSTRACT: Objectives: To determine the effectiveness of aerosolised 3% saline in hospitalised children with acute bronchiolitis. Design: Prospective, randomized, double blinded clinical study. Setting: Referral teaching hospital, from October 2007 to March 2009. Patients: 40 children [age less than 2 yrs] were enrolled sequentially and randomized into 2 groups [20 each; Group- A - 3% saline and Group-B [Normal saline]. Intervention: 4 nebulizations [3% saline or normal s...

  10. Etiological diagnosis reduces the use of antibiotics in infants with bronchiolitis

    Directory of Open Access Journals (Sweden)

    Ângela Esposito Ferronato

    2012-09-01

    Full Text Available OBJECTIVE: Acute bronchiolitis is a leading cause of infant hospitalization and is most commonly caused by respiratory syncytial virus. Etiological tests are not required for its diagnosis, but the influence of viral screening on the therapeutic approach for acute bronchiolitis remains unclear. METHODS: A historical cohort was performed to assess the impact of viral screening on drug prescriptions. The study included infants up to one year of age who were hospitalized for bronchiolitis. Virus screening was performed using immunofluorescence assays in nasopharyngeal aspirates. The clinical data were obtained from the patients' medical records. Therapeutic changes were considered to be associated with viral screening when made within 24 hours of the release of the results. RESULTS: The frequency of prescriptions for beta agonists, corticosteroids and antibiotics was high at the time of admission and was similar among the 230 patients. The diagnosis of pneumonia and otitis was associated with the introduction of antibiotics but did not influence antibiotics maintenance after the results of the virus screening were obtained. Changes in the prescriptions were more frequent for the respiratory syncytial virus patients compared to patients who had negative viral screening results (p =0.004, especially the discontinuation of antibiotics (p<0.001. The identification of respiratory syncytial virus was associated with the suspension of antibiotics (p= 0.003, even after adjusting for confounding variables (p = 0.004; however, it did not influence the suspension of beta-agonists or corticosteroids. CONCLUSION: The identification of respiratory syncytial virus in infants with bronchiolitis was independently associated with the discontinuation of antibiotics during hospitalization

  11. Diffuse Neuroendocrine Hyperplasia with Obliterative Bronchiolitis and Usual Interstitial Pneumonia: An Unusual "Headcheese Pattern" with Nodules.

    Science.gov (United States)

    Pietrangeli, V; Piciucchi, S; Tomassetti, S; Ravaglia, C; Gurioli, C; Gurioli, Ch; Cavazza, A; Dubini, A; Poletti, V

    2015-12-01

    A 74-year-old non-smoker female presented to our attention with a history of dyspnea and cough. CT scan revealed multiple areas of patchy ground glass attenuation associated to a diffuse mosaic oligoemia. Scattered bilateral subcentimetric pulmonary nodules were also present. Patient underwent a surgical lung biopsy. Specimens showed features of diffuse neuroendocrine hyperplasia, microhoneycombing, fibroblast foci. A final diagnosis of diffuse neuroendocrine hyperplasia with obliterative bronchiolitis and UIP was rendered. PMID:26446675

  12. Matrilysin-1 Mediates Bronchiolization of Alveoli, a Potential Premalignant Change in Lung Cancer

    OpenAIRE

    Wang, Xiao-Yang; Demelash, Abeba; Kim, Heungnam; Jensen-Taubman, Sandra; Dakir, El Habib; Ozbun, Laurent; Birrer, Michael J.; Linnoila, R. Ilona

    2009-01-01

    Matrilysin-1 (also called matrix metalloproteinase-7) is expressed in injured lung and in cancer but not in normal epithelia. Bronchiolization of the alveoli (BOA), a potential precursor of lung cancer, is a histologically distinct type of metaplasia that is composed of cells resembling airway epithelium in the alveolar compartment. We demonstrate that there is increased expression of matrilysin-1 in human lesions and BOA in the CC10-human achaete-scute homolog-1 transgenic mouse model. Force...

  13. Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial

    OpenAIRE

    Cunningham, Steve; Rodriguez Carbonell, Aryelly; Adams, Tim; Boyd, Kathleen A; Butcher, Isabella; Enderby, Beth; MacLean, Morag; McCormick, Jonathan; Paton, James Y; Wee, Fiona; Thomas, Huw; Riding, Kay; Turner, Steve W.; Williams, Chris; McIntosh, Emma

    2015-01-01

    BACKGROUND: The American Academy of Pediatrics recommends a permissive hypoxaemic target for an oxygen saturation of 90% for children with bronchiolitis, which is consistent with the WHO recommendations for targets in children with lower respiratory tract infections. No evidence exists to support this threshold. We aimed to assess whether the 90% or higher target for management of oxygen supplementation was equivalent to a normoxic 94% or higher target for infants admitted to hospital with vi...

  14. Rib fractures after chest physiotherapy for bronchiolitis or pneumonia in infants

    International Nuclear Information System (INIS)

    Heading AbstractBackground. The reported causes of rib fractures in infants are: child abuse, accidental injury, cardiopulmonary resuscitation, bone fragility, birth trauma and severe cough.Objective. To report chest physiotherapy (CPT) as a new cause of rib fractures in five infants.Materials and methods. We retrospectively identified all infants with rib fractures after CPT for bronchiolitis or pneumonia over a 4-year period in two paediatric and one paediatric radiology units in three university hospitals in Paris.Results. Five boys were identified. Their median age was 3 months. None had any other potential cause of rib fractures. The indication for CPT was bronchiolitis in four cases and pneumonia in one. The median number of rib fractures was four (range 1-5). Fractures were located between the 3rd and 8th ribs; they were lateral in four patients and posterior in one; they were unilateral in four patients and bilateral in one. Evolution was favourable in all cases. The prevalence of rib fractures after CPT during the study period was estimated at 1 in 1,000 infants hospitalised for bronchiolitis or pneumonia.Conclusions. CPT should be considered a potential, but very rare cause of rib fractures in infants. It can be of clinical relevance when rib fractures are the only feature suggestive of child abuse. (orig.)

  15. Clinical significance of changes of plasma CGRP and VIP levels in infants with bronchiolitis

    International Nuclear Information System (INIS)

    Objective: To explore the clinical significance of changes of calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) levels in infants (2-24months) with bronchiolitis. Methods: Plasma levels of CGRP and VIP were determined with RIA in 31 infants with bronchiolitis both during acute infection and convalescence as well as in 35 controls. Results: Plasma CGRP levels in patients during acute infection were significantly higher than those in patients during convalescence and in controls (P<0.05). Levels of CGRP dropped during convalescence, but still remained significantly higher than those in controls (P<0.05). The reverse was true for the plasma VIP levels. The plasma VIP levels in patients during acute infection were significantly lower than those in patients during convalescence and in controls (P<0.05). During convalescence, the plasma VIP levels rose but remained significantly lower than those in controls (P<0.05). Conclusion: There were dynamic changes of plasma CGRP and VIP levels in the course of infant bronchiolitis and the two peptides played opposite roles. (authors)

  16. Rib fractures after chest physiotherapy for bronchiolitis or pneumonia in infants

    Energy Technology Data Exchange (ETDEWEB)

    Chalumeau, Martin [Service de Pneumologie et d' Allergologie Pediatriques, Hopital Necker-Enfants Malades, Paris (France); Service de Pediatrie, Hopital Saint-Vincent-de-Paul, Paris (France); Foix-l' Helias, Laurence; Scheinmann, Pierre; Zuani, Pierre [Service de Pneumologie et d' Allergologie Pediatriques, Hopital Necker-Enfants Malades, Paris (France); Gendrel, Dominique [Service de Pediatrie, Hopital Saint-Vincent-de-Paul, Paris (France); Ducou-le-Pointe, Hubert [Service de Radiologie, Hopital d' Enfants Armand-Trousseau, Avenue du Docteur Arnold Netter, 75571 Paris Cedex 12 (France)

    2002-09-01

    Heading AbstractBackground. The reported causes of rib fractures in infants are: child abuse, accidental injury, cardiopulmonary resuscitation, bone fragility, birth trauma and severe cough.Objective. To report chest physiotherapy (CPT) as a new cause of rib fractures in five infants.Materials and methods. We retrospectively identified all infants with rib fractures after CPT for bronchiolitis or pneumonia over a 4-year period in two paediatric and one paediatric radiology units in three university hospitals in Paris.Results. Five boys were identified. Their median age was 3 months. None had any other potential cause of rib fractures. The indication for CPT was bronchiolitis in four cases and pneumonia in one. The median number of rib fractures was four (range 1-5). Fractures were located between the 3rd and 8th ribs; they were lateral in four patients and posterior in one; they were unilateral in four patients and bilateral in one. Evolution was favourable in all cases. The prevalence of rib fractures after CPT during the study period was estimated at 1 in 1,000 infants hospitalised for bronchiolitis or pneumonia.Conclusions. CPT should be considered a potential, but very rare cause of rib fractures in infants. It can be of clinical relevance when rib fractures are the only feature suggestive of child abuse. (orig.)

  17. The Use of Albuterol in Young Infants Hospitalized with Acute RSV Bronchiolitis

    Directory of Open Access Journals (Sweden)

    Michael T. Del Vecchio

    2012-01-01

    Full Text Available Objective. To evaluate the effects of albuterol use in young infants admitted with respiratory syncytial virus (RSV bronchiolitis with regards to length of time on supplemental oxygen and length of stay (LOS. To consider the possibility that albuterol use may increase the need for supplemental oxygen and increase LOS. Design, Setting, and Participants. Full-term infants between the ages of 11 days and 90 days (=316 were included in this retrospective study. Infants included were hospitalized with a diagnosis of RSV bronchiolitis at a university-affiliated children’s hospital. Results. In 4 of 5 severity groups, patients who received albuterol required more time on supplemental oxygen and had longer LOS. The differences only reached statistical significance in one of the severity groups in regards to LOS. Conclusions. The use of albuterol does not appear to be useful in the treatment of young infants with RSV bronchiolitis and may actually be harmful, in regards to increased supplemental oxygen need.

  18. Acute viral bronchiolitis in children- a very common condition with few therapeutic options.

    Science.gov (United States)

    Wainwright, Claire

    2010-03-01

    Acute viral bronchiolitis remains a cause of substantial morbidity and health care costs in young infants. It is the most common lower respiratory tract condition and most common reason for admission to hospital in infants. Many respiratory viruses have been associated with acute viral bronchiolitis although respiratory syncytial virus (RSV) remains the most frequently identified virus. Most infants have a mild self limiting illness while others have more severe illness and require hospital admission and some will need ventilatory support. Differences in innate immune function in response to the respiratory viral insult as well as differences in the geometry of the airways may explain some of the variability in clinical pattern. Young age and history of prematurity remain the most important risk factors although male gender, indigenous status, exposure to tobacco smoke, poor socioeconomic factors and associated co-morbidities such as chronic lung disease and congenital heart disease increase the risks of more severe illness. Supportive therapy remains the major treatment option as no specific treatments to date have been shown to provide clinically important benefits except for inhaled hypertonic saline. Prophylaxis of high risk infants with palivizumab should be considered although the cost effectiveness is still unclear. Many questions remain regarding optimal management approaches for infants requiring hospitalisation with bronchiolitis including use of nasogastric feeding, the optimal role of supplemental oxygen, optimal use of hypertonic saline and the role of combinations of therapies, the use of heliox or modern physiotherapy approaches.

  19. Predicting the severity of acute bronchiolitis in infants: should we use a clinical score or a biomarker?

    Science.gov (United States)

    Amat, Flore; Henquell, Cécile; Verdan, Matthieu; Roszyk, Laurence; Mulliez, Aurélien; Labbé, André

    2014-11-01

    Krebs von den Lungen 6 antigen (KL-6) has been shown to be a useful biomarker of the severity of Respiratory syncytial virus bronchiolitis. To assess the correlation between the clinical severity of acute bronchiolitis, serum KL-6, and the causative viruses, 222 infants with acute bronchiolitis presenting at the Pediatric Emergency Department of Estaing University Hospital, Clermont-Ferrand, France, were prospectively enrolled from October 2011 to May 2012. Disease severity was assessed with a score calculated from oxygen saturation, respiratory rate, and respiratory effort. A nasopharyngeal aspirate was collected to screen for a panel of 20 respiratory viruses. Serum was assessed and compared with a control group of 38 bronchiolitis-free infants. No significant difference in KL-6 levels was found between the children with bronchiolitis (mean 231 IU/mL ± 106) and those without (230 IU/mL ± 102), or between children who were hospitalized or not, or between the types of virus. No correlation was found between serum KL-6 levels and the disease severity score. The absence of Human Rhinovirus was a predictive factor for hospitalization (OR 3.4 [1.4-7.9]; P = 0.006). Older age and a higher oxygen saturation were protective factors (OR 0.65[0.55-0.77]; P < 0.0001 and OR 0.67 [0.54-0.85] P < 0.001, respectively). These results suggest that in infants presenting with bronchiolitis for the first time, clinical outcome depends more on the adaptive capacities of the host than on epithelial dysfunction intensity. Many of the features of bronchiolitis are affected by underlying disease and by treatment. PMID:24374757

  20. Predicting the severity of acute bronchiolitis in infants: should we use a clinical score or a biomarker?

    Science.gov (United States)

    Amat, Flore; Henquell, Cécile; Verdan, Matthieu; Roszyk, Laurence; Mulliez, Aurélien; Labbé, André

    2014-11-01

    Krebs von den Lungen 6 antigen (KL-6) has been shown to be a useful biomarker of the severity of Respiratory syncytial virus bronchiolitis. To assess the correlation between the clinical severity of acute bronchiolitis, serum KL-6, and the causative viruses, 222 infants with acute bronchiolitis presenting at the Pediatric Emergency Department of Estaing University Hospital, Clermont-Ferrand, France, were prospectively enrolled from October 2011 to May 2012. Disease severity was assessed with a score calculated from oxygen saturation, respiratory rate, and respiratory effort. A nasopharyngeal aspirate was collected to screen for a panel of 20 respiratory viruses. Serum was assessed and compared with a control group of 38 bronchiolitis-free infants. No significant difference in KL-6 levels was found between the children with bronchiolitis (mean 231 IU/mL ± 106) and those without (230 IU/mL ± 102), or between children who were hospitalized or not, or between the types of virus. No correlation was found between serum KL-6 levels and the disease severity score. The absence of Human Rhinovirus was a predictive factor for hospitalization (OR 3.4 [1.4-7.9]; P = 0.006). Older age and a higher oxygen saturation were protective factors (OR 0.65[0.55-0.77]; P bronchiolitis for the first time, clinical outcome depends more on the adaptive capacities of the host than on epithelial dysfunction intensity. Many of the features of bronchiolitis are affected by underlying disease and by treatment.

  1. Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.

    Directory of Open Access Journals (Sweden)

    Dara G Torgerson

    Full Text Available Severe infection with respiratory syncytial virus (RSV during infancy is strongly associated with the development of asthma. To identify genetic variation that contributes to asthma following severe RSV bronchiolitis during infancy, we sequenced the coding exons of 131 asthma candidate genes in 182 European and African American children with severe RSV bronchiolitis in infancy using anonymous pools for variant discovery, and then directly genotyped a set of 190 nonsynonymous variants. Association testing was performed for physician-diagnosed asthma before the 7th birthday (asthma using genotypes from 6,500 individuals from the Exome Sequencing Project (ESP as controls to gain statistical power. In addition, among patients with severe RSV bronchiolitis during infancy, we examined genetic associations with asthma, active asthma, persistent wheeze, and bronchial hyperreactivity (methacholine PC20 at age 6 years. We identified four rare nonsynonymous variants that were significantly associated with asthma following severe RSV bronchiolitis, including single variants in ADRB2, FLG and NCAM1 in European Americans (p = 4.6x10-4, 1.9x10-13 and 5.0x10-5, respectively, and NOS1 in African Americans (p = 2.3x10-11. One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888, which was also nominally associated with asthma (p = 0.027 and active asthma (p = 0.013 among European Americans with severe RSV bronchiolitis without including the ESP. Our results suggest that rare nonsynonymous variants contribute to the development of asthma following severe RSV bronchiolitis in infancy, notably in ADRB2. Additional studies are required to explore the role of rare variants in the etiology of asthma and asthma-related traits following severe RSV bronchiolitis.

  2. The Effect(s of Vitamin A on Persistent Wheezing after Bronchiolitis in Infants Aged 1-12 Months

    Directory of Open Access Journals (Sweden)

    S Sharafian

    2015-04-01

    Full Text Available Background & aim: Viral bronchiolitis is one of the most common causeS of lower respiratory tract infection and almost responsible for 1-3% of hospitalization among children under one year of age. Post bronchiolitis wheezing is the main risk factor for childhood asthma, and its control can decrease incidence of the disease in future. The purpose of this study was to investigate the effect of vitamin A on persistent wheezing after bronchiolitis. Methods: The present double blind clinical trial was conducted on 84 patients aged 1 to 12 months of age who were admitted in Imam Sajad Hospital of Yasuj from October 2012 to 2013. After viral bronchiolitis diagnosis of patients with history and physical exam, they were divided into two similar groups of control and case randomly. Control group received cold and wet nebulized oxygen and bronchodilator and case group received the same protocol together with 5000 IU/kg Vitamin A intramascularlly. Both groups were examined by the same physician before, one and two weeks after treatment and quality and severity of wheezing was recorded. Data were analyzed by statistical student T – test and chi square test. Results: Intensity and quality of wheezing was similar in both groups before the intervention(85/0 = p=0.858 whereas a significant reduction was observed in the severity of wheezing in the group receiving vitamin A compared with the control group (05/0> p<0.05. Conclusion: A significant decrease was observed in persistent wheezing after intramascular administration of a dose of vitamin A in patients requiring hospitalization due to viral bronchiolitis. Administrating one dose vitamin A intramuscularly in patients who need hospitalization due to bronchiolitis, may decrease post bronchiolitis and persistent wheezing.

  3. Frequency, duration and predictors of bronchiolitis episodes of care among infants ≥32 weeks gestation in a large integrated healthcare system: a retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Flaherman Valerie J

    2012-06-01

    Full Text Available Abstract Background Bronchiolitis is common in the first two years of life and is the most frequent cause of hospitalization in this age group. No previous studies have used an episode-of-care analysis to describe the frequency, duration, and predictors of bronchiolitis episodes of care during the first two years. Methods We conducted a retrospective cohort study of 123,264 infants ≥32 weeks gestation born at 6 Northern California Kaiser Permanente hospitals between 1996 and 2002. We used electronic medical records to concatenate hospital, emergency department and outpatient health care encounters for bronchiolitis into discrete episodes of care. We used descriptive statistics to report frequency and duration of bronchiolitis episodes and used logistic regression to assess the effect of gestational age and other clinical and demographic predictors on the outcome of bronchiolitis episodes. Results Among all infants, the rate of bronchiolitis episodes was 162 per 1000 children during the first 2 years of life; approximately 40% required >1 day of medical attention with a mean duration of 7.0 ± 5.9 days. Prematurity was associated with increased risk of bronchiolitis episodes and longer duration. Bronchiolitis episodes rates per 1000 infants were 246 for 32–33 weeks gestational age, 204 for 34–36 weeks, and 148–178 for >36 weeks. Male gender, African-American and Hispanic race/ethnicity, and parental history of asthma were associated with an increased risk of having a bronchiolitis episode and/or longer duration. Conclusions Bronchiolitis episodes of care are frequent during the first two years of life and the duration ranges from 1 to 27 days. Prematurity was associated with more frequent and longer duration of bronchiolitis episodes of care, which may reflect illness severity and/or perceived vulnerability.

  4. The effect of high flow nasal cannula therapy on the work of breathing in infants with bronchiolitis.

    Science.gov (United States)

    Pham, Trang M T; O'Malley, Lee; Mayfield, Sara; Martin, Simon; Schibler, Andreas

    2015-07-01

    The main physiological impact of high flow nasal cannula (HFNC) therapy is presumed to be a decrease in work of breathing (WOB). To assess this, diaphragmatic electrical activity and esophageal pressure changes were measured off then on HFNC delivered at 2 L/kg/min, in 14 infants with bronchiolitis and 14 cardiac infants. Electrical activity of the diaphragm (Edi) was measured using an Edi catheter with calculations of signal peak (EdiMAX ) and amplitude (EdiAMPL ). Pressure-rate and pressure-time products (PRP, PTP) were calculated from analyses of esophageal pressure. Changes in end-expiratory lung volume were measured using respiratory inductance plethysmography (RIPEEL ). The EdiMAX and EdiAMPL were significantly higher in infants with bronchiolitis than in cardiac infants (P bronchiolitis group, both were significantly reduced between HFNC states from 27.9 µV [20.4, 35.4] to 21.0 µV [14.8, 27.2] and from 25.1 µV [18.0, 32.2] to 19.2 µV [13.3, 25.1], respectively (mean, 95% CI, P bronchiolitis only (P bronchiolitis. A similar effect was demonstrated in cardiac infants, a group without signs of airway-obstruction.

  5. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children

    DEFF Research Database (Denmark)

    Bisgaard, H.; Flores-Nunez, A.; Goh, A.;

    2008-01-01

    (RSV) bronchiolitic respiratory symptoms. OBJECTIVES: To evaluate the efficacy and safety of montelukast, 4 and 8 mg, in treating recurrent respiratory symptoms of post-RSV bronchiolitis in children in a large, multicenter study. METHODS: This was a double-blind study of 3- to 24-month-old children who...... had been hospitalized for a first or second episode of physician-diagnosed RSV bronchiolitis and who tested positive for RSV. Patients (n = 979) were randomized to placebo or to montelukast at 4 or 8 mg/day for 4 weeks (period I) and 20 weeks (period II). The primary end point was percentage symptom.......7 (0.0, 11.3) for montelukast (4 mg) minus placebo and 5.9 (0.1, 11.7) for montelukast (8 mg) minus placebo. CONCLUSIONS: In this study, montelukast did not improve respiratory symptoms of post-RSV bronchiolitis in children Udgivelsesdato: 2008/10/15...

  6. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Flores-Nunez, Alejandro; Goh, Anne;

    2008-01-01

    (RSV) bronchiolitic respiratory symptoms. OBJECTIVES: To evaluate the efficacy and safety of montelukast, 4 and 8 mg, in treating recurrent respiratory symptoms of post-RSV bronchiolitis in children in a large, multicenter study. METHODS: This was a double-blind study of 3- to 24-month-old children who...... had been hospitalized for a first or second episode of physician-diagnosed RSV bronchiolitis and who tested positive for RSV. Patients (n = 979) were randomized to placebo or to montelukast at 4 or 8 mg/day for 4 weeks (period I) and 20 weeks (period II). The primary end point was percentage symptom.......7 (0.0, 11.3) for montelukast (4 mg) minus placebo and 5.9 (0.1, 11.7) for montelukast (8 mg) minus placebo. CONCLUSIONS: In this study, montelukast did not improve respiratory symptoms of post-RSV bronchiolitis in children....

  7. Physical therapy for airway clearance improves cardiac autonomic modulation in children with acute bronchiolitis

    Directory of Open Access Journals (Sweden)

    Cynthia P. Jacinto

    2013-12-01

    Full Text Available BACKGROUND: The effects of physical therapy on heart rate variability (HRV, especially in children, are still inconclusive. OBJECTIVE: We investigated the effects of conventional physical therapy (CPT for airway clearance and nasotracheal suction on the HRV of pediatric patients with acute bronchiolitis. METHOD: 24 children were divided into two groups: control group (CG, n=12 without respiratory diseases and acute bronchiolitis group (BG, n=12. The heart rate was recorded in the BG at four different moments: basal recording (30 minutes, 5 minutes after the CPT (10 minutes, 5 minutes after nasotracheal suction (10 minutes, and 40 minutes after nasotracheal suction (30 minutes. The CG was subjected to the same protocol, except for nasotracheal suction. To assess the HRV, we used spectrum analysis, which decomposes the heart rate oscillations into frequency bands: low frequency (LF=0.04-0.15Hz, which corresponds mainly to sympathetic modulation; and high frequency (HF=0.15-1.2Hz, corresponding to vagal modulation. RESULTS: Under baseline conditions, the BG showed higher values in LF oscillations, lower values in HF oscillations, and increased LF/HF ratio when compared to the CG. After CPT, the values for HRV in the BG were similar to those observed in the CG during basal recording. Five minutes after nasotracheal suction, the BG showed a decrease in LF and HF oscillations; however, after 40 minutes, the values were similar to those observed after application of CPT. CONCLUSIONS: The CPT and nasotracheal suction, both used for airway clearance, promote improvement in autonomic modulation of HRV in children with acute bronchiolitis.

  8. Interferon gamma Profile in Egyptian Infants with Respiratory Syncytial Virus bronchiolitis

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    Maha E. Omran1, Mohamed AE. Fahmy2, Manal M. Zaher3

    2008-03-01

    Full Text Available Viral bronchiolitis is one of the leading causes for hospitalization of infants in the world and causes an estimated one million deaths per year worldwide. Respiratory syncytial virus (RSV is associated with the majority of cases. During the last few years it has become increasingly clear that T cells contribute to the abnormal regulation of the immune response in viral diseases since these cells are potent producers of a large variety of cytokines. It was reported that cord blood interferon gamma (IFN- responses were inversely related to the frequency of viral respiratory infections. To ascertain whether RSV infection promotes a different IFN- profile to that induced by other respiratory infections, thirty-two infants with severe bronchiolitis were enrolled in this study. RSV-IgM was detected by immunofluorescent technique in 23/32 patients. Serum IFN- levels in RSV+ infants were significantly lower than RSV- (p < 0.001. In vitro stimulation of peripheral blood cells followed by flow cytometery combined with intracellular cytokine staining revealed that both CD4+ and CD8+ cells contribute in IFN- production. The percentage of CD4+ cells producing IFN- in RSV+ was significantly lower (P < 0.05 than those in RSV-, while the difference in % of CD8+ between RSV+ and RSV- was non significant. Our conclusions are that RSV infection is associated with severe decreased IFN- responses. Both CD4+ and CD8+ cells contribute in IFN- production during RSV bronchiolitis. RSV infection promotes a different IFN- profile from that induced by other respiratory infections.

  9. [Very rare and life-threatening complications of bocavirus bronchiolitis: pneumomediastinum and bilateral pneumothorax].

    Science.gov (United States)

    Yeşilbaş, Osman; Kıhtır, Hasan Serdar; Talip Petmezci, Mey; Balkaya, Seda; Hatipoğlu, Nevin; Meşe, Sevim; Şevketoğlu, Esra

    2016-01-01

    Human bocavirus (HBoV), that was first identified in 2005 and classified in Parvoviridae family, is a small, non-enveloped, single-stranded DNA virus, responsible for upper and lower respiratory tract infections, especially in young children. Although HBoV generally causes self-limited influenza-like illness, it may also lead to pneumonia, bronchiolitis, croup and asthma attacks. In this report, a case of acute bronchiolitis complicated with pneumomediastinum and bilateral pneumothorax caused by HBoV has been presented. A three-year-old boy was referred to our pediatric intensive care unit with a two day history of fever, tachypnea, hypoxia and respiratory failure. On auscultation, there were widespread expiratory wheezing and inspiratory crackles. The chest radiography yielded paracardiac infiltration and air trapping on the right lung and infiltration on the left lung. The patient had leukocytosis and elevated C-reactive protein level. On the second day of admission, respiratory distress worsened and chest radiography revealed right pneumothorax and subcutaneous emphysema in bilateral cervical region and left chest wall. He was intubated because of respiratory failure. In the thorax computed tomography, pneumomediastinum and bilateral pneumothorax were detected and right chest tube was inserted. Repetitive blood and tracheal aspirate cultures were negative. A nasopharyngeal swab sample was analyzed by multiplex real-time polymerase chain reaction method with the use of viral respiratory panel (FTD(®) Respiratory Pathogens 21 Kit, Fast-Track Diagnostics), and positive result was detected for only HBoV. On the ninth day of admission, pneumomediastinum and bilateral pneumothorax improved completely and he was discharged with cure. In conclusion, HBoV bronchiolitis may progress rare but severe complications, it should be kept in mind as an etiological agent of the respiratory tract infections especially children younger than five years old.

  10. Respiratory bronchiolitis: radiographic and CT findings in a pathologically proven case

    Energy Technology Data Exchange (ETDEWEB)

    Essadki, O.; Chartrand-Lefebvre, C.; Grenier, P. [Department of Radiology, Pitie-Salpetrire Hospital, Paris (France); Briere, J. [Department of Pathology, Laennec Hospital, Paris (France)

    1998-12-01

    A small number of cases of cigarette-smoking-associated respiratory bronchiolitis (RB) with positive findings on the chest radiograph have been reported in the literature. High-resolution computed tomography (HRCT) findings are available in even fewer cases. We describe the case of an asymptomatic female smoker presenting with a reticulomicronodular infiltrate on a routine chest radiograph. High-resolution CT was characterized by ground-glass opacities and centrilobular micronodules with an upper lobe predominance. Surgical biopsy revealed peribronchiolar lesions, with accumulation of brown pigmented macrophages in the lumen of alveolar and bronchiolar lumen, consistent with the pathologic diagnosis of RB. (orig.) With 3 figs., 12 refs.

  11. Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma.

    Science.gov (United States)

    Goksel, Ozlem; Nart, Deniz; Ergonul, Ayse Gul; Sever, Fidan; Goksel, Tuncay

    2015-07-01

    Follicular bronchiolitis (FB) is a rare small-airway pathology that is associated mainly with connective tissue diseases. This case report presents a new, diagnosed, different airway disease in a non-smoker with rheumatoid arthritis in remission who was treated for presumed asthma, but was not controlled. She was ultimately diagnosed with FB after video-assisted thoracoscopic surgery. The clinical findings of FB were controlled successfully by colchicine after she did not respond to systemic steroid therapy. This is the first case report of FB associated with rheumatoid arthritis that responded to colchicine.

  12. Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs

    DEFF Research Database (Denmark)

    Rottbøll, Lisa Amanda Holm; Friis, Christian

    2014-01-01

    through a tracheostomy into the distal bronchioles using an insertion tube. Intravenously administered inulin served as a marker of extracellular fluid contamination of PELF. Concentrations of free drug in MD fractions were compared to total and non-protein-bound drug concentrations in plasma. Rising...... equipment, the danofloxacin concentrations in PELF were consistent within the different administration groups. The described MD method for drug quantification in PELF is easily accessible and provides repeatable results. However, trace amount of inulin was detected in the MD fractions, suggesting a local...

  13. A Case of Follicular Bronchiolitis as the Histological Counterpart to Nodular Opacities in Bronchiectatic Mycobacterium avium Complex Disease

    Directory of Open Access Journals (Sweden)

    Kentaro Wakamatsu

    2012-01-01

    Full Text Available Here we report the case of a 72-year-old woman with nodular bronchiectatic Mycobacterium avium complex (MAC disease. Chest computed tomography on admission revealed multiple micronodular and branching opacities in both lobes with segmental distribution; bronchiectasis and bronchial wall thickening were observed in the middle lobe and lingula. The patient consented to and underwent thoracoscopic lung biopsy; epithelioid granulomas were occasionally observed, but follicular bronchiolitis was widespread. While bronchial lesions from nontuberculous mycobacterial infection generally present as epitheliod granulomas, the present case suggests that follicular bronchiolitis can also be a histological counterpart to nodular opacities in nodular bronchiectatic MAC disease.

  14. Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost.

    Science.gov (United States)

    Melillo, Elio; Grigoratos, Chrysanthos; Sanctis, Francesco De; Spontoni, Paolo; Nuti, Marco; Dell'Omodarme, Matteo; Ferrari, Mauro; Balbarini, Alberto

    2015-07-01

    We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPo 2) and carbon dioxide (TcPco 2) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44°C (P < .005). Forefoot maximal hyperemic test at 44°C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

  15. Computerized acoustic assessment of treatment efficacy of nebulized epinephrine and albuterol in RSV bronchiolitis

    Directory of Open Access Journals (Sweden)

    Talmon Gil

    2007-06-01

    Full Text Available Abstract Aim We evaluated the use of computerized quantification of wheezing and crackles compared to a clinical score in assessing the effect of inhaled albuterol or inhaled epinephrine in infants with RSV bronchiolitis. Methods Computerized lung sounds analysis with quantification of wheezing and crackles and a clinical score were used during a double blind, randomized, controlled nebulized treatment pilot study. Infants were randomized to receive a single dose of 1 mgr nebulized l-epinephrine or 2.5 mgr nebulized albuterol. Computerized quantification of wheezing and crackles (PulmoTrack® and a clinical score were performed prior to, 10 minutes post and 30 minutes post treatment. Results were analyzed with Student's t-test for independent samples, Mann-Whitney U test and Wilcoxon test. Results 15 children received albuterol, 12 received epinephrine. The groups were identical at baseline. Satisfactory lung sounds recording and analysis was achieved in all subjects. There was no significant change in objective quantification of wheezes and crackles or in the total clinical scores either within the groups or between the groups. There was also no difference in oxygen saturation and respiratory distress. Conclusion Computerized lung sound analysis is feasible in young infants with RSV bronchiolitis and provides a non-invasive, quantitative measure of wheezing and crackles in these infants. Trial registration number: ClinicalTrials.gov NCT00361452

  16. The role of TLR4 and CD14 polymorphisms in the pathogenesis of respiratory syncytial virus bronchiolitis in greek infants.

    Science.gov (United States)

    Goutaki, M; Haidopoulou, K; Pappa, S; Tsakiridis, P; Frydas, E; Eboriadou, M; Hatzistylianou, M

    2014-01-01

    Clinical manifestations of respiratory syncytial virus (RSV) infection vary from minimal disease to severe acute bronchiolitis. The structural complex of TLR4/CD14 participates in the virus recognition as a component of natural immune response. Genetic variations of TLR4/CD14 may explain great variations in disease severity. The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis. Our study included two groups of Greek infants and young children (A and B). Group A consisted of 50 infants ≤2 years of age hospitalised with bronchiolitis and group B of 99 previously healthy children aged 4-14 years (control group) with a free past medical history. RSV was identified by PCR of genetic material that was extracted from nasopharyngeal samples collected from all patients. Blood samples were used to extract DNA and by using the PCR-RFLP method we performed TLR4 and CD14 genotyping. We found no association between TLR4 polymorphisms (Asp299Gly and Thr399Ile) and the development of acute bronchiolitis. For CD14 polymorphisms, a positive association was found between the C-159T and the development of bronchiolitis (p=0.05) but not for the other loci. There were no differences detected in the frequencies of the four polymorphisms studied among infants with RSV and non-RSV bronchiolitis. It is concluded that protein CD14 may have a functional role in the viral conjunction to the structural complex TLR4/CD14. The association between the polymorphism C-159T and the manifestation of disease found in our study points out that the severity in the development of acute bronchiolitis is not specified exclusively by the pathogen, but the immune response of the host also plays a significant role. More extensive multicentric studies need to take place, in order to lead to safer conclusions.

  17. Pneumothorax in an early phase after allogeneic hematopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Yasuhiro Ebihara

    2013-06-01

    Full Text Available Pneumothorax is very rare after early phase of hematopoietic stem cell transplantation (HSCT and usually accompanied with pulmonary chronic graft-versus-host disease (GVHD, such as bronchiolitis obliterans and bronchiolitis obliterans organizing pneumonia. The present study describes the case of a seventeen-year-old male diagnosed with acute myeloid leukemia who underwent allogeneic bone marrow transplantation (BMT. Pneumothorax occurred at day 43 after BMT. Pneumothorax occurred in early phase of HSCT is extremely rare. The early onset of acute GVHD and the entity of cytomegalovirus might worsen the pulmonary tissue damages for the onset of pneumothorax, indicating that we should be aware of the possibility to occur pneumothorax even in the early period after allogeneic HSCT.

  18. The use of C-reactive protein in predicting bacterial co-Infection in children with bronchiolitis

    Directory of Open Access Journals (Sweden)

    Mohamad Fares

    2011-03-01

    Full Text Available Background: Bronchiolitis is a potentially life-threatening respiratory illness commonly affecting children who are less than two years of age. Patients with viral lower respiratory tract infection are at risk for co-bacterial infection. Aim: The aim of our study was to evaluate the use of C-reactive protein (CRP in predicting bacterial co-infection in patients hospitalized for bronchiolitis and to correlate the results with the use of antibiotics. Patients and Methods: This is a prospective study that included patients diagnosed with bronchiolitis admitted to Makassed General Hospital in Beirut from October 2008 to April 2009. A tracheal aspirate culture was taken from all patients with bronchiolitis on admission to the hospital. Blood was drawn to test C-reactive protein level, white cell count, transaminases level, and blood sugar level. Results: Forty-nine patients were enrolled in the study and were divided into two groups. Group 1 included patients with positive tracheal aspirate culture and Group 2 included those with negative culture. All patients with a CRP level ≥2 mg/dL have had bacterial co-infection. White cell count, transaminases and blood sugar levels were not predictive for bacterial co-infection. The presence of bacterial co-infection increased the length of hospital stay in the first group by 2 days compared to those in the second group. Conclusion: Bacterial co-infection is frequent in infants with moderate to severe bronchiolitis and requires admission. Our data showed that a CRP level greater than 1.1 mg/dL raised suspicion for bacterial co-infection. Thus, a tracheal aspirate should be investigated microbiologically in all hospitalized patients in order to avoid unnecessary antimicrobial therapy and to shorten the duration of the hospital stay.

  19. Effectiveness of chest physiotherapy in infants hospitalized with acute bronchiolitis: a multicenter, randomized, controlled trial.

    Directory of Open Access Journals (Sweden)

    Vincent Gajdos

    2010-09-01

    Full Text Available Acute bronchiolitis treatment in children and infants is largely supportive, but chest physiotherapy is routinely performed in some countries. In France, national guidelines recommend a specific type of physiotherapy combining the increased exhalation technique (IET and assisted cough (AC. Our objective was to evaluate the efficacy of chest physiotherapy (IET + AC in previously healthy infants hospitalized for a first episode of acute bronchiolitis.We conducted a multicenter, randomized, outcome assessor-blind and parent-blind trial in seven French pediatric departments. We recruited 496 infants hospitalized for first-episode acute bronchiolitis between October 2004 and January 2008. Patients were randomly allocated to receive from physiotherapists three times a day, either IET + AC (intervention group, n=246 or nasal suction (NS, control group, n=250. Only physiotherapists were aware of the allocation group of the infant. The primary outcome was time to recovery, defined as 8 hours without oxygen supplementation associated with minimal or no chest recession, and ingesting more than two-thirds of daily food requirements. Secondary outcomes were intensive care unit admissions, artificial ventilation, antibiotic treatment, description of side effects during procedures, and parental perception of comfort. Statistical analysis was performed on an intent-to-treat basis. Median time to recovery was 2.31 days, (95% confidence interval [CI] 1.97-2.73 for the control group and 2.02 days (95% CI 1.96-2.34 for the intervention group, indicating no significant effect of physiotherapy (hazard ratio [HR]=1.09, 95% CI 0.91-1.31, p=0.33. No treatment by age interaction was found (p=0.97. Frequency of vomiting and transient respiratory destabilization was higher in the IET + AC group during the procedure (relative risk [RR]=10.2, 95% CI 1.3-78.8, p=0.005 and RR=5.4, 95% CI 1.6-18.4, p=0.002, respectively. No difference between groups in bradycardia with or

  20. The Therapeutic Effect of Gamma Interferon in Chronic Bronchiolitis Due to Mustard Gas

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    Yunes Panahi

    2005-06-01

    In the two groups, FEV1 did not have statistical differences at base line (49.3±2.9 and 48.7±4.1, respectively, p = 0.6, whereas after treatment the data for FEV1 showed a significant increase in the case group (66.3±5.4 when compared with those in the control group (57.3±8.6, p=0.001. The findings of this study indicate that a 6-month treatment with interferon gamma -1b plus a low-dose of prednisolone is associated with the improvement of the lung function in mustard gas exposed patients with bronchiolitis

  1. The impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis.

    Science.gov (United States)

    Zhou, Lili; Xiao, Qiuyan; Zhao, Yao; Huang, Ailong; Ren, Luo; Liu, Enmei

    2015-08-01

    The impact of dynamic respiratory syncytial virus (RSV) load on the clinical severity of hospitalized infants with bronchiolitis has not been clarified. Nasopharyngeal aspirates were obtained from 60 infants who were diagnosed with bronchiolitis within 96 hr of wheezing onset upon admission and on days 3, 5, and 7 in the hospital, and 17 respiratory viruses were detected. The RSV load was quantified by real-time qPCR for RSV subtypes A and B at different time points. Scoring criteria were used to evaluate the degree of severity. A total of 40 infants were determined to be RSV-positive, nine were identified as RSV subtype A (RSVA), and 31 were RSV subtype B (RSVB). The peak RSV load was observed upon admission, and the RSV load decreased significantly over time; in addition, this decrease began to have significant differences on day 5. There was a positive correlation between the RSV load and the clinical score (r(2)  = 0.121 and P < 0.001). According to the clinical scores, the infants in the severe group tended to have higher RSV loads than those in the moderate and mild groups. Multivariate logistic regression models revealed that the viral load on day 3 was independently associated with the degree of severity. This study elucidated that a higher mean RSV load was associated with a more severe disease and a longer duration of hospitalization and symptoms. This study also clarified RSV replication in infants and provides a theoretical basis for specifying an anti-RSV therapy strategy.

  2. Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers.

    Science.gov (United States)

    Duling, Matthew G; LeBouf, Ryan F; Cox-Ganser, Jean M; Kreiss, Kathleen; Martin, Stephen B; Bailey, Rachel L

    2016-10-01

    Obliterative bronchiolitis in five former coffee processing employees at a single workplace prompted an exposure study of current workers. Exposure characterization was performed by observing processes, assessing the ventilation system and pressure relationships, analyzing headspace of flavoring samples, and collecting and analyzing personal breathing zone and area air samples for diacetyl and 2,3-pentanedione vapors and total inhalable dust by work area and job title. Mean airborne concentrations were calculated using the minimum variance unbiased estimator of the arithmetic mean. Workers in the grinding/packaging area for unflavored coffee had the highest mean diacetyl exposures, with personal concentrations averaging 93 parts per billion (ppb). This area was under positive pressure with respect to flavored coffee production (mean personal diacetyl levels of 80 ppb). The 2,3-pentanedione exposures were highest in the flavoring room with mean personal exposures of 122 ppb, followed by exposures in the unflavored coffee grinding/packaging area (53 ppb). Peak 15-min airborne concentrations of 14,300 ppb diacetyl and 13,800 ppb 2,3-pentanedione were measured at a small open hatch in the lid of a hopper containing ground unflavored coffee on the mezzanine over the grinding/packaging area. Three out of the four bulk coffee flavorings tested had at least a factor of two higher 2,3-pentanedione than diacetyl headspace measurements. At a coffee processing facility producing both unflavored and flavored coffee, we found the grinding and packaging of unflavored coffee generate simultaneous exposures to diacetyl and 2,3-pentanedione that were well in excess of the NIOSH proposed RELs and similar in magnitude to those in the areas using a flavoring substitute for diacetyl. These findings require physicians to be alert for obliterative bronchiolitis and employers, government, and public health consultants to assess the similarities and differences across the industry to

  3. Impact of hospitalizations for bronchiolitis in preterm infants on long-term health care costs in Italy: a retrospective case-control study

    OpenAIRE

    Roggeri, Alessandro; Roggeri,Daniela Paola; Rossi, Elisa; Cataudella,Salvatore; Martini, Nello

    2016-01-01

    Daniela Paola Roggeri,1 Alessandro Roggeri,1 Elisa Rossi,2 Salvatore Cataudella,2 Nello Martini,3 1ProCure Solutions, Nembro, Bergamo, 2CINECA Interuniversity Consortium, Bologna, 3Accademia Nazionale di Medicina, Rome, Italy Purpose: Bronchiolitis is an acute inflammatory injury of the bronchioles, and is the most frequent cause of hospitalization for lower respiratory tract infections in preterm infants. This was a retrospective, observational, case-control study conducted in Italy...

  4. RSV毛细支气管炎及其后反复喘息的相关影响因素分析%The correlation factor about respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infant

    Institute of Scientific and Technical Information of China (English)

    田曼; 赵德育; 文惯宇; 施圣云

    2009-01-01

    目的 探讨与呼吸道合胞病毒(RSV)致毛细支气管炎(简称细支炎)及其后反复喘息发作相关的影响因素.方法 对RSV细支炎住院患儿与正常对照组儿童生活生长各因素进行比较,并随访RSV细支炎患儿两年内喘息再发的情况,以期找到与RSV细支炎及其后婴幼儿反复喘息相关的危险因素.结果 ①RSV细支炎组与正常对照组通过Logistic回归分析,筛选出非母乳喂养、被动吸烟、未补充维生素(Vii)AD为具有统计学意义的危险因素.②200例RSV细支炎患儿随访两年,失访82例,细支炎后再发喘息组71例,未再发生喘息组47例.两组通过Logistic回归分析,筛选出被动吸烟、未补充Vit AD、个人特应史、家族特应史为具有统计学意义的危险因素.两组外周血嗜酸细胞计数、RANTES因子、血总IgE水平及TH1/TH2值差异有统计学意义.结论 ①非母乳喂养、被动吸烟、未补充Vit AD为RSV细支炎的危险因素.②被动吸烟、未补充Vit AD、个人特应史、家族特应史为RSV细支炎后反复喘息的危险因素.%Objective To ohserve the correlation factor about early-life RSV bronchiolitis and sequential recurrent wheezing for two years.Methods Follow up the RSV bronehiolitis patients for two years in order to analyze the occurrence of wheezing post-bronchiolitis.Single and multiple logistic regression analysis were used to determined the risk factors such as individual atopy history and familial atopy history,pet feeding,breast milk,secondhand smoke for RSV bronchiolitis and subsequent wheezing.Results①Not breast feeding,exposure to cigarette smoke and the deficiency of VitA.D were the significant risk factors contributed to the RSV bronchiolitis.②Exposure to cigarette smoke,the deficiency of VitA,D,the personal history of atopy and the family history of atopy were the significant risk factors contributed to the post-bronchiolitis wheezing in children.③Those patients who eosinophilia

  5. The Role of Human Milk Immunomodulators in Protecting Against Viral Bronchiolitis and Development of Chronic Wheezing Illness

    Directory of Open Access Journals (Sweden)

    Dani-Louise Dixon

    2015-07-01

    Full Text Available Infants who are breastfed are at an immunological advantage when compared with formula fed infants, evidenced by decreased incidence of infections and diminished propensity for long term conditions, including chronic wheeze and/or asthma. Exclusive breastfeeding reduces the duration of hospital admission, risk of respiratory failure and requirement for supplemental oxygen in infants hospitalised with bronchiolitis suggesting a potentially protective mechanism. This review examines the evidence and potential pathways for protection by immunomodulatory factors in human milk against the most common viral cause of bronchiolitis, respiratory syncytial virus (RSV, and subsequent recurrent wheeze in infants. Further investigations into the interplay between respiratory virus infections such as RSV and how they affect, and are affected by, human milk immunomodulators is necessary if we are to gain a true understanding of how breastfeeding protects many infants but not all against infections, and how this relates to long-term protection against conditions such as chronic wheezing illness or asthma.

  6. The Role of Human Milk Immunomodulators in Protecting Against Viral Bronchiolitis and Development of Chronic Wheezing Illness.

    Science.gov (United States)

    Dixon, Dani-Louise

    2015-07-07

    Infants who are breastfed are at an immunological advantage when compared with formula fed infants, evidenced by decreased incidence of infections and diminished propensity for long term conditions, including chronic wheeze and/or asthma. Exclusive breastfeeding reduces the duration of hospital admission, risk of respiratory failure and requirement for supplemental oxygen in infants hospitalised with bronchiolitis suggesting a potentially protective mechanism. This review examines the evidence and potential pathways for protection by immunomodulatory factors in human milk against the most common viral cause of bronchiolitis, respiratory syncytial virus (RSV), and subsequent recurrent wheeze in infants. Further investigations into the interplay between respiratory virus infections such as RSV and how they affect, and are affected by, human milk immunomodulators is necessary if we are to gain a true understanding of how breastfeeding protects many infants but not all against infections, and how this relates to long-term protection against conditions such as chronic wheezing illness or asthma.

  7. Interstitial inflammatory lesions of the pulmonary allograft: a retrospective analysis of 2697 transbronchial biopsies

    DEFF Research Database (Denmark)

    Burton, C.M.; Iversen, M.; Carlsen, J.;

    2008-01-01

    of 2697 biopsies were evaluated corresponding to a mean of 6+/-2 (median 8) completed schedules per patient. Diffuse alveolar damage (DAD) was the second most common histological finding within the first 2 weeks after transplantation. The peak prevalence of bronchiolitis obliterans organizing pneumonia......, incidence and possible associations between commonly identified inflammatory and fibrotic lesions in the pulmonary allograft. METHODS: Retrospective chart review of all transbronchial biopsies performed within the first 2 years of 299 lung-transplanted patients in the period 1996 to 2006. RESULTS: A total.......0001, respectively). Acute cellular rejection was not associated with DAD, and patients with lymphocytic bronchiolitis were not more likely to demonstrate features of organizing pneumonia (DAD or BOOP). CONCLUSIONS: Histologic findings of ACR, lymphocytic bronchiolitis, BOOP, and interstitial pneumonitis were...

  8. Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis.

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    Eero Lauhkonen

    Full Text Available Toll-like receptors (TLR play a crucial role in innate immunity, protecting the host from pathogens such as viruses. Genetic variations in TLRs have been associated with the severity of viral bronchiolitis in infancy and with the later occurrence of post-bronchiolitis asthma. The aim of the present study was to evaluate if there are any exploratory associations between TLR gene polymorphisms and lung function at 5 to 7 years of age in former bronchiolitis patients.We performed impulse oscillometry (IOS at the median age of 6.3 years for 103 children who had been hospitalized for bronchiolitis at less than six months of age. The main parameters evaluated were airway resistance and reactance at 5Hz in baseline and post-exercise measurements. Data on single nucleotide polymorphisms (SNP of TLR1 rs5743618, TLR2 rs5743708, TLR6 rs5743810 and TLR10 rs4129009 (TLR2 subfamily and TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992 and TLR 9 rs187084 were available for analyses.The TLR4 rs4986790 wild genotype A/A was associated with a greater Rrs5 response (0.72 vs. -0.42, p = 0.03 to exercise. In TLR6 rs5743810, the minor allele T was associated with greater Rrs5 response (0.80 vs. -0.03, p = 0.04 to exercise. In TLR7 rs179008, the major allele A was associated with baseline decline in dRrs/df (-1.03 vs 0.61, p = 0.01 and increased Fres (2.28 vs. 0.89, p = 0.01 in girls.Among the nine studied TLRs, only TLR7 rs179008 showed some exploratory associations with post-bronchiolitis lung function deficiency, and polymorphisms of TLR4 rs4986790, and TLR6 rs5743810 in particular, with airway reactivity. These findings call for further confirmatory studies.

  9. Impact of hospitalizations for bronchiolitis in preterm infants on long-term health care costs in Italy: a retrospective case-control study

    Directory of Open Access Journals (Sweden)

    Roggeri DP

    2016-08-01

    Full Text Available Daniela Paola Roggeri,1 Alessandro Roggeri,1 Elisa Rossi,2 Salvatore Cataudella,2 Nello Martini,3 1ProCure Solutions, Nembro, Bergamo, 2CINECA Interuniversity Consortium, Bologna, 3Accademia Nazionale di Medicina, Rome, Italy Purpose: Bronchiolitis is an acute inflammatory injury of the bronchioles, and is the most frequent cause of hospitalization for lower respiratory tract infections in preterm infants. This was a retrospective, observational, case-control study conducted in Italy, based on administrative database analysis. The aim of this study was to evaluate differences in health care costs of preterm infants with and without early hospitalization for bronchiolitis. Patients and methods: Preterm infants born in the period between January 1, 2009 and December 31, 2010 and hospitalized for bronchiolitis in the first year of life were selected from the ARNO Observatory database and observed for the first 4 years of life. These preterm infants were compared (paired 1–3 with preterm infants who were not hospitalized for bronchiolitis in the first year of life and with similar characteristics. Only direct health care costs reimbursed by the Italian National Health Service were considered for this study (drugs, hospitalizations, and diagnostic/therapeutic procedures. Results: Of 40,823 newborns in the accrual period, 863 were preterm with no evidence of prophylaxis, and 22 preterm infants were hospitalized for bronchiolitis (cases and paired with 62 controls. Overall, cases had 74% higher average cost per infant in the first 4 years of life than controls (18,624€ versus 10,189€, respectively. The major cost drivers were hospitalizations, accounting for >90% in both the populations. The increase in total yearly health care cost between cases and controls remained substantial even in the fourth year of life for all cost items. A relevant increase in hospitalizations and drug consumption linked to respiratory tract diseases was noted in

  10. Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs.

    Science.gov (United States)

    Rottbøll, Lisa A H; Friis, Christian

    2014-03-01

    Target site drug determinations are crucial for optimizing treatment of infectious diseases. There is limited knowledge of antibiotic drug penetration into the pulmonary epithelial lining fluid (PELF) and a lack of easily performed methods for continuous drug sampling hereof. The aim of this study was to develop a readily accessible microdialysis (MD) method for antibiotic drug quantification in PELF of pigs. The fluoroquinolone danofloxacin was administered to anaesthetized pigs allocated to three groups: intravenous injection, intravenous infusion and intramuscular injection. MD probes were guided through a tracheostomy into the distal bronchioles using an insertion tube. Intravenously administered inulin served as a marker of extracellular fluid contamination of PELF. Concentrations of free drug in MD fractions were compared to total and non-protein-bound drug concentrations in plasma. Rising and declining danofloxacin plasma concentrations were rapidly reflected in PELF, suggesting an efficient drug transport across the blood bronchial barrier. The AUC FREE DRUG PELF /AUC FREE DRUG PLASMA ratio was 1.8 (S.D. 0.4, 95% CL 1.4-2.3). Although the probes were placed without fiberscopic or other special equipment, the danofloxacin concentrations in PELF were consistent within the different administration groups. The described MD method for drug quantification in PELF is easily accessible and provides repeatable results. However, trace amount of inulin was detected in the MD fractions, suggesting a local tissue reaction induced by the MD membrane. The significance of this finding needs to be clarified in future studies.

  11. Prevention of bronchiolitis from the hospital to home: enviromental and pharmacological strategies

    Directory of Open Access Journals (Sweden)

    Andrea Dotta

    2015-10-01

    Full Text Available Bronchiolitis is one of the major cause of mortality and morbidity during infancy, with high hospitalization rate during epidemic season for high risk infants during the first year of life. There is no specific therapy with proven efficacy apart hydration and hypertonic saline. Mild forms can be treated in outpatient setting avoiding a useless hospitalization. Enviromental prevention is crucial in hospital setting, in outpatient ambulatory and at home: for this purpose hand hygiene, tobacco exposure, breastfeeding must be emphasized with families and caregivers. Pharmacological prophylaxis uses a humanized monoclonal antibody (palivizumab shown effective in reducing hospitalization rate in preterm infants < 35 weeks gestational age, infants with bronchopulmonary dysplasia and infants with congenital heart disease. During the last 2 years different recommandations and guidelines confirmed the importance of prophylaxis with palivizumab with some differences between Groups and Societies based on different healthcare systems. In any case it is important a good contact between hospital and all caregivers of these patients to reduce the viral exposure and increase the defense capability of high risk patients. Proceedings of the 11th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy · October 26th-31st, 2015 · From the womb to the adultGuest Editors: Vassilios Fanos (Cagliari, Italy, Michele Mussap (Genoa, Italy, Antonio Del Vecchio (Bari, Italy, Bo Sun (Shanghai, China, Dorret I. Boomsma (Amsterdam, the Netherlands, Gavino Faa (Cagliari, Italy, Antonio Giordano (Philadelphia, USA

  12. Nutritional status, breastfeeding, and evolution of Infants with acute viral bronchiolitis.

    Science.gov (United States)

    Dornelles, Cristina T L; Piva, Jefferson P; Marostica, Paulo J C

    2007-09-01

    Acute viral bronchiolitis is a common respiratory infectious disease of infancy. A prospective study was carried out with 175 infants aged up to six months to evaluate their nutritional and breastfeeding status as possible risk factors for unfavourable evolution of previously-healthy infants from a care hospital. Immunofluorescence test for virus and anthropometric assessment were performed. Outcomes were length of oxygen-use, length of hospital stay, and type of hospital unit needed. Seventy-three percent of the infants were well-nourished, 6% undernourished, 8.6% at a nutritional risk, 10.9% overweight, and 1.7% obese. Eighty-one percent of the undernourished and nutritionally at-risk infants and 72% of the well-nourished, overweight, and obese infants did not receive exclusive breastfeeding. The median length of hospital stay was four days and of oxygen-use was 60 hours. The nutritional status did not affect the clinical course of previously-healthy infants with acute viral brochiolitis. The duration of exclusive breastfeeding, but not type of breastfeeding, was inversely related to the length of oxygen-use and the length of hospital stay. Shorter exclusive breastfeeding was observed in infants who were assigned to a paediatric ward or to an intensive care unit. In conclusion, longer duration of breastfeeding was associated with better clinical outcomes.

  13. Advancement of T helper17 cells in bronchiolitis%Th17与毛细支气管炎的研究进展

    Institute of Scientific and Technical Information of China (English)

    张国辉

    2013-01-01

    Bronchiolitis is a common lower respiratory infection disease in children younger than two years old.The main pathogen of bronchiolitis is respiratory syncytial virus,which is also associated with the asthma.By now,it is still unknown about the pathogenesis of bronchiolitis.Recent findings provide that T helper17(Th17) cells play an important role in bronchiolitis.This review summarizes the progresses of regulation of Th17 cells development,Th17 cells function,and the relationship between Th17 cells and bronchiolitis.%毛细支气管炎(毛支)是2岁以下小儿常见的下呼吸道感染性疾病,主要病原体是呼吸道合胞病毒,是需住院治疗的常见呼吸道疾病,且与哮喘的发病密切相关.目前毛支的发病机制尚未完全阐明,近年来发现T辅助性17细胞(Th17)在其发病中占有重要地位.该文就近年来对Th17在毛支发病机制方面的研究进展作一综述.

  14. Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing.

    Science.gov (United States)

    Bertrand, Pablo; Lay, Margarita K; Piedimonte, Giovanni; Brockmann, Pablo E; Palavecino, Christian E; Hernández, Jury; León, Miguel A; Kalergis, Alexis M; Bueno, Susan M

    2015-12-01

    Respiratory Syncytial Virus (RSV) is the first cause of hospitalization due to bronchiolitis in infants. RSV bronchiolitis has been linked to asthma and recurrent wheezing, however the mechanisms behind this association have not been elucidated. Here, we evaluated the cytokine and chemokine profiles in the airways in infants with RSV bronchiolitis. Nasopharyngeal Aspirates (NPA) and Bronchoalveolar Lavage Fluids (BALF) from infants hospitalized due to RSV bronchiolitis and healthy controls were analyzed for cytokine and chemokine production. We observed elevated levels of Th2 cytokines (IL-3, IL-4, IL-10 and IL-13), pro-inflammatory cytokines and chemokines (IL-1β, IL-6, TNF-β, MCP-1/CCL2, MIP-1α/CCL3 and IL-8/CXCL8) in BALF from infants with RSV bronchiolitis, as compared to controls. We found a direct correlation of IL-3 and IL-12p40 levels with the development of recurrent wheezing later in life. These results suggest that IL-3 and IL-12p40 could be considered as molecular predictors for recurrent wheezing due to RSV infection.

  15. Immune mechanisms of obliterative bronchiolitis following lung transplantation%肺移植闭塞性细支气管炎免疫机制研究进展

    Institute of Scientific and Technical Information of China (English)

    王光锁; 王正; 孙宗全

    2008-01-01

    闭塞性细支气管炎是影响肺移植患者长期生存的主要因素.适应性免疫一直是肺移植排斥反应的研究重点.但是越来越多的研究表明,体液免疫、自体免疫、固有免疫等亦是闭塞性细支气管炎发生的重要因素.%Chronic rejection remains the leading cause of chronic allograft dysfunction and late mortality after lung transplantation. Adaptive immune system and its cellular-based rejection has been the focus in the development of obliterative bronchiolitis. Recent research has identified that humoral immunity, autoimmunity, and innate immunity also contribute to obliterative bronchiolitis. This paper presents an updated review of the immune mechanisms for obliterative bronchiolitis following lung transplantation.

  16. Bronchiolitis and Leukotriene Receptor Antagonist%毛细支气管炎与白三烯受体拮抗剂

    Institute of Scientific and Technical Information of China (English)

    马晓晖

    2011-01-01

    Bronchiolitis is the most common lower respiratory tract infection in infants, the major cause of which is virus infection. Studies have indicated that there are many similarities in pathophysiology between bronchiolitis and asthma, and there are many inflammatory mediators involved,which result in airway hyperresponsiveness, and lead to wheeze. Among the inflammatory mediators, leukotriene plays an important role in bronchiolitis airway inflammation, so leukotriene receptor antagonist is an effective treatment for bronchiolitis.Here is to review the mechanism of leukotriene receptor antagonist and its clinical studies in bronchiolitis,in order to disclose a better treatment and effective early intervention method of bronchiolitis, and to cut down the relapse rate of wheezing.%毛细支气管炎是婴幼儿常见的下呼吸道感染性疾病,病毒感染是主要致病原因.毛细支气管炎的病理、生理变化与哮喘有许多相同之处,许多炎性介质参与其中,造成呼吸道高反应,诱发喘息.在这些炎性介质中,白三烯在毛细支气管炎呼吸道炎症的发生中起到重要作用,而白三烯受体拮抗剂在毛细支气管炎的治疗中取得较好疗效.现就白三烯受体拮抗剂的作用机制及其在毛细支气管炎中的临床研究进行综述,探讨毛细支气管炎的治疗及早期干预以及降低喘息复发率的有效方法.

  17. Concentrations of IL-15, IL-18, IFN-γ and activity of CD4(+), CD8(+) and NK cells at admission in children with viral bronchiolitis.

    Science.gov (United States)

    Grześk, Elżbieta; Kołtan, Sylwia; Dębski, Robert; Wysocki, Mariusz; Gruszka, Marzena; Kubicka, Małgorzata; Kołtan, Andrzej; Grześk, Grzegorz; Manysiak, Sławomir; Odrowąż-Sypniewska, Grażyna

    2010-09-01

    The pathogenesis of viral bronchiolitis is poorly understood. The aim of this study was to analyze interleukin (IL)-15, IL-18 and interferon (IFN)-γ concentrations and the activity of NK cells and CD4(+) and CD8(+) lymphocytes in 23 children not older than 30 months of age with acute viral bronchiolitis using blood samples drawn within the first 24 h of their hospital admission, in comparison to a healthy group. In children with bronchiolitis, the mean concentrations of IL-15, IL-18 and IFN-γ were 9.39±11.55, 884.03±645.44 and 17.92±27.14 pg/ml, respectively, and were significantly higher than those in the control group [2.34±0.61 pg/ml (p<0.05), 248.69±98.73 pg/ml (p<0.001) and 2.75±1.72 pg/ml (p<0.005), respectively]. In the bronchiolitis group, mean z-scores were -1.15±1.9 for CD4(+) cells and -0.9±1.23 for CD8(+) cells; these scores were significantly lower than those of the general Polish population (p<0.001 and <0.01, respectively). However, the mean z-score of the ratio of CD4(+)/CD8(+) and the NK cell count in children with bronchiolitis did not differ significantly from those of the controls. In conclusion, cytokines such as IL-15, IL-18 and IFN-γ play a role in the pathogenesis of bronchiolitis in children.

  18. Incidence and risk factors of hospitalization for bronchiolitis in preterm children: a retrospective longitudinal study in Italy

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    Mucchino Eleonora

    2009-09-01

    Full Text Available Abstract Background Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects infants. We evaluated the incidence and risk factors of hospitalization for broncholitis in preterm infants (i.e., a gestational age of Methods Retrospective cohort study that linked data from four health administrative databases in the Lazio region (a region of central Italy: the birth register, the hospital discharge register, and two ad-hoc databases that record the doses of Palivizumab administered at two local health units. Results Among 2407 preterm infants, 137 had at least one hospitalization for bronchiolitis in the first 18 months of life, an overall incidence rate of 4.70 per 100 person-years (95%CI: 3.98-5.56; similar incidence rates were observed by calendar year. A multiple Poisson model showed that the following characteristics were associated with higher incidence: younger age of the infant, the period between October-April, male gender, low Apgar score at birth, low birth weight, and low maternal educational level. At least one dose of Palivizumab was administered to 324 (13.5% children; a dramatic increase from 2000 (2.8% to 2006 (19.1% (p Conclusion In Italy the incidence of hospitalization for bronchiolitis, and its associated risk factors, are similar to that found in other countries. Although Palivizumab use is associated with the most important characteristics of severe prematurity, other aspects of its non-use in children with congenital heart disease, the age and the birth country of the mother suggest the need for public health measures that can reduce these health disparities. Finally, the estimated effectiveness of Palivizumab in routine practice, although not significant, confirms the results of previous clinical trials, but its impact on modifying the temporal trend in this population is still negligible.

  19. Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993–2000: a population-based retrospective study

    Directory of Open Access Journals (Sweden)

    Bratlid Dag

    2004-12-01

    Full Text Available Abstract Background RSV is recognized as the most important cause of serious lower respiratory tract illness in infants and young children worldwide leading to hospitalisation in a great number of cases, especially in certain high-risk groups. The aims of the present study were to identify risk groups, outcome and incidences of hospitalisation for RSV bronchiolitis in Norwegian children under two years of age and to compare the results with other studies. Methods We performed a population-based retrospective survey for the period 1993–2000 in children under two years of age hospitalised for RSV bronchiolitis. Results 822 admissions from 764 patients were identified, 93% had one hospitalisation, while 7% had two or more hospitalisations. Mean annual hospitalisation incidences were 21.7 per 1.000 children under one year of age, 6.8 per 1.000 children at 1–2 years of age and 14.1 per 1.000 children under two years of age. 77 children (85 admissions belonged to one or more high-risk groups such as preterm birth, trisomy 21 and congenital heart disease. For preterm children under one year of age, at 1–2 years of age and under two years of age hospitalisation incidences per 1.000 children were 23.5, 8.7 and 16.2 respectively. The incidence for children under two years of age with trisomy 21 was 153.8 per 1.000 children. Conclusion While the overall hospitalisation incidences and outcome of RSV bronchiolitis were in agreement with other studies, hospitalisation incidences for preterm children were lower than in many other studies. Age on admission for preterm children, when corrected for prematurity, was comparable to low-risk children. Length of hospitalisation and morbidity was high in both preterm children, children with a congenital heart disease and in children with trisomy 21, the last group being at particular high risk for severe disease.

  20. Progress of research on follicular bronchiolitis%滤泡性细支气管炎研究进展

    Institute of Scientific and Technical Information of China (English)

    陈石; 张德平

    2009-01-01

    Follicular bronchiolitis is a histopathological diagnosis,and is characterized with follicular hyperplasia in lymphoid germinal center and bronchiole wall.It is often associated with chronic infections and inflammatory airway diseases such as cystic fibrosis,bronchiectasis,chronic aspiration,connective tissue diseases,including immunodeficiency syndrome like AIDS.Chest imaging mainly manifests small nodules or reticular shadow,accompanied with intrathoracic lymph nodes,nodules and ground-glass shadow diffuse distribution in both lungs,located at the bronchial perivascular tissues.Clinical manifestations and imaging can be used to make the diagnosis of follicular bronchiolitis.It is usually lack of treatment means but have a good prognosis.%滤泡性细支气管炎是一个组织病理学诊断,以细支气管壁伴有生发中心的淋巴样滤泡增生为特征.常与慢性感染和炎症性气道疾病,例如囊性纤维化、支气管扩张、慢性误吸、结缔组织疾病、包括获得性免疫缺陷综合征在内的免疫缺陷综合征有一定的相关性.在胸部影像学主要表现为两肺小结节或网状阴影,伴有胸腔内淋巴结肿大,结节和毛玻璃样影可以两肺弥漫性分布,主要位于支气管血管周围.结合临床表现和影像学表现可以用于滤泡性细支气管炎的诊断.治疗缺乏特效治疗手段,一般预后较好.

  1. Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function.

    Science.gov (United States)

    Sorkness, Ronald L; Szakaly, Renee J; Rosenthal, Louis A; Sullivan, Ruth; Gern, James E; Lemanske, Robert F; Sun, Xin

    2013-11-01

    Viral illness with wheezing during infancy is associated with the inception of childhood asthma. Small airway dysfunction is a component of childhood asthma, but little is known about how viral illness at an early age may affect the structure and function of small airways. We used a well-characterized rat model of postbronchiolitis chronic airway dysfunction to address how postinfectious small airway lesions affect airway physiological function and if the structure/function correlates persist into maturity. Brown Norway rats were sham- or virus inoculated at 3 to 4 weeks of age and allowed to recover from the acute illness. At 3 to 14 months of age, physiology (respiratory system resistance, Newtonian resistance, tissue damping, and static lung volumes) was assessed in anesthetized, intubated rats. Serial lung sections revealed lesions in the terminal bronchioles that reduced luminal area and interrupted further branching, affecting 26% (range, 13-39%) of the small airways at 3 months of age and 22% (range, 6-40%) at 12 to 14 months of age. At 3 months of age (n = 29 virus; n = 7 sham), small airway lesions correlated with tissue damping (rs = 0.69) but not with Newtonian resistance (rs = 0.23), and Newtonian resistance was not elevated compared with control rats, indicating that distal airways were primarily responsible for the airflow obstruction. Older rats (n = 7 virus; n = 6 sham) had persistent small airway dysfunction and significantly increased Newtonian resistance in the postbronchiolitis group. We conclude that viral airway injury at an early age may induce small airway lesions that are associated quantitatively with small airway physiological dysfunction early on and that these defects persist into maturity.

  2. Acute respiratory bronchiolitis: an ultrastructural and autoradiographic study of epithelial cell injury and renewal in Rhesus monkeys exposed to ozone

    International Nuclear Information System (INIS)

    The pathogenesis of acute respiratory bronchiolitis was examined in Rhesus monkeys exposed to 0.8 ppM ozone for 4 to 50 hours. Epithelial injury and renewal were qualitatively and quantitatively characterized by correlated techniques of scanning and transmission electron microscopy as well as by light-microscopic autoradiography following labeling with tritiated thymidine. Extensive degeneration and necrosis of Type 1 epithelial cells occurred on the respiratory bronchiolar wall during the initial 4 to 12 hours of exposure. Increased numbers of labeled epithelial cells were present in this region after 18 hours of exposure, and the highest labeling index (18%) was measured after 50 hours of exposure. Most (67 to 80%) of the labeled cells and all the mitotic epithelial cells (22) observed ultrastructurally were cuboidal bronchiolar epithelial cells. Of the labeled epithelial cells, 20 to 33% were Type 2 epithelial cells. After 50 hours of exposure the respiratory bronchiolar epithelium was hyperplastic. The predominant inflammatory cell in respiratory bronchiolar exudate was the alveolar macrophage. Monkeys that were exposed for 50 hours and allowed to recover in unozonized air for 7 days had incomplete resolution of respiratory bronchiolar epithelial hyperplasia. The results indicate that Type 1 epithelial cells lining respiratory bronchioles are the cell types most sensitive to injury and that both cuboidal bronchiolar epithelial cells and Type 2 epithelial cells function as stem cells in epithelial renewal

  3. Treatment of Infantile Bronchiolitis with Jie Jing Ding Chuan Zhi Xiao Tang——A Report of 45 Cases

    Institute of Scientific and Technical Information of China (English)

    Feng Xiaochun; An Xiaoran; Mao Shuzhang

    2006-01-01

    Objective:To evaluate the therapeutic effectiveness of Jie Jing Ding Chuan Zhi Xiao Tang (解痉定喘止哮汤 the Tetany- Pant- and Wheeze-relieving Decoction) on infantile bronchiolitis. Method: Seventy-five eligible cases were randomly divided into a treatment group (N = 45) and a control group (N=30). Patients in the treatment group were treated with Tetany-Pant- and Wheeze-relieving Decoction, the ingredients of which include Su Zi (苏子 Fructus Perillae), Di Long (地龙 Pheretima), Qian Hu (前胡 Radix Peucedani),Bai Qu Cai (白屈菜 Herba Chelidonii), Ma Huang (麻黄 Herba Ephedrae), Ku Xing Ren (苦杏仁 Semen Armeniacae Amarum), Bai Gou (白果 Semen Gingkgo), Quan Xie (全蝎 Scorpio), Bai Xian Pi (白鲜皮Cortex Dictamni), Jiang Can (僵蚕 Bombyx Batryticatus), She Gan (射干 Rhizoma Belamcandae) and Dong Hua ( 冬花 Flos Farfarae). Patients in the control group were treated with Xiao Er Ke Chun Ling Chong Ji (小儿咳喘灵冲剂 Medicinal Granules for Infantile Cough and Pant). Result: A total effective rate of 93.3% was achieved in the treatment group and only 73.3% was obtained in the control group.Conclusion: The Tetany- Pant- and Wheeze-relieving Decoction is significantly effective in treating infantile bronchiolitis (P<0.05).

  4. Broad respiratory virus detection in infants hospitalized for bronchiolitis by use of a multiplex RT-PCR DNA microarray system.

    Science.gov (United States)

    Huguenin, Antoine; Moutte, Lauryane; Renois, Fanny; Leveque, Nicolas; Talmud, Deborah; Abely, Michel; Nguyen, Yohan; Carrat, Fabrice; Andreoletti, Laurent

    2012-06-01

    Newly available molecular tools allow a sensitive detection of a broad panel of viruses in respiratory tract specimens. In the present study, the application of a multiplex RT-PCR DNA microarray in diagnosis and epidemiological survey of viral infections in infants hospitalized for bronchiolitis was assessed. One hundred and thirty-eight nasopharyngeal aspirates collected from October 2007 to September 2008 were tested by direct immunofluorescence and viral culture, a combination of referenced RT-PCRs and the DNA microarray. One or more viruses were detected in 96, 126 and 126 of the specimens by direct immunofluorescence and viral culture, RT-PCRs and DNA microarray, respectively (70 vs. 91 vs. 91%, P 0.1). In conclusion, the use of this DNA microarray in clinical virology practice allows rapid and accurate identification of common and uncommon viral respiratory pathogens in infants hospitalized for bronchiolitis. It should improve the clinical management, the epidemiological survey, and the prevention of the nosocomial transmission of respiratory viruses in pediatric wards. PMID:22499022

  5. Activation of endothelial and epithelial K(Ca) 2.3 calcium-activated potassium channels by NS309 relaxes human small pulmonary arteries and bronchioles

    DEFF Research Database (Denmark)

    Kroigaard, Christel; Dalsgaard, Thomas; Nielsen, Gorm;

    2012-01-01

    BACKGROUND AND PURPOSE: Small (K(Ca) 2) and intermediate (K(Ca) 3.1) conductance calcium-activated potassium channels (K(Ca) ) may contribute to both epithelium- and endothelium-dependent relaxations, but this has not been established in human pulmonary arteries and bronchioles. Therefore, we...... investigated the expression of K(Ca) 2.3 and K(Ca) 3.1 channels, and hypothesized that activation of these channels would produce relaxation of human bronchioles and pulmonary arteries. EXPERIMENTAL APPROACH: Channel expression and functional studies were conducted in human isolated small pulmonary arteries...... and bronchioles. K(Ca) 2 and K(Ca) 3.1 currents were examined in human small airways epithelial (HSAEpi) cells by whole-cell patch clamp techniques. RESULTS: While K(Ca) 2.3 expression was similar, K(Ca) 3.1 protein was more highly expressed in pulmonary arteries than bronchioles. Immunoreactive K(Ca) 2.3 and K...

  6. New Progress in Drug Therapy in Children with Bronchiolitis%小儿毛细支气管炎的药物治疗新进展

    Institute of Scientific and Technical Information of China (English)

    庞智东

    2015-01-01

    本文主要介绍小儿毛细支气管炎的药物治疗进展。通过查阅整理相关资料,再结合丰富的临床经验,对小儿毛细支气管炎的药物治疗予以综述分析。小儿毛细支气管炎的药物治疗主要分为中医、西医及中西结合三种方式。小儿毛细支气管炎的临床诊治,应根据患儿状况及病情程度,合理选取药物治疗、给药方式及剂量,往往中西结合的疗效更为理想。%This paper described progress in drug treatment of children with bronchiolitis. After a review of the compilation of relevant data, combined with a wealth of clinical experience, be re-viewed analysis of the drug treatment of children with bronchiolitis. Drug treatment of children with bronchiolitis are divided into traditional Chinese medicine, Western medicine and Western combined in three ways.The clinical diagnosis of bronchiolitis in children, should be based on the situation of children and severity, reasonable selection of medication, administration and dosage, often more desirable effect of combining Chinese and Western.

  7. IL1RL1 Gene Variants and Nasopharyngeal IL1RL-a Levels Are Associated with Severe RSV Bronchiolitis : A Multicenter Cohort Study

    NARCIS (Netherlands)

    Faber, Tina E.; Schuurhof, Annemieke; Vonk, Annelies; Koppelman, Gerard H.; Hennus, Marije P.; Kimpen, Jan L. L.; Janssen, Riny; Bont, Louis J.

    2012-01-01

    Background: Targets for intervention are required for respiratory syncytial virus (RSV) bronchiolitis, a common disease during infancy for which no effective treatment exists. Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. Hu

  8. 毛细支气管炎发病中细胞因子作用的研究进展%Research progress on cytokine of bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    张秀秀; 曲书强

    2011-01-01

    Bronchiolitis is the most common lower respiratory tract inflammation in infants caused by a variety of pathogens.As bronchiolitis and asthma share similar clinical manifestations,changes of cytokines and inflammatory factors,it is believed that brondiiorhitis has a similar pathogenesis as asthma.Therefore,researches on cytokines in bronchiolitis are of great importance to reveal the pathogenesis and explore new treatments of bronchiolitis.%毛细支气管炎是由多种病原引起的婴幼儿最常见的下呼吸道感染性疾病.由于毛细支气管炎与哮喘具有相似的临床表现、细胞因子和炎症因子的改变,认为其可能具有与哮喘相似的发病机制.因此,毛细支气管炎细胞因子研究对揭示毛细支气管炎的发病机制,探索毛细支气管炎新的治疗方法具有极其重要的作用.

  9. T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis.

    Science.gov (United States)

    Li, Maoxiang; Harkema, Jack R; Islam, Zahidul; Cuff, Chistopher F; Pestka, James J

    2006-11-15

    Exposure to immunosuppressive environmental contaminants is a possible contributing factor to increased occurrence of viral respiratory diseases. The objective of this study was to test the hypothesis that the trichothecene mycotoxin T-2 toxin (T-2), a frequent food contaminant, alters host resistance to lung infection by reovirus, a model respiratory virus. Balb/c mice (4 week old) were treated intraperitoneally with T-2 toxin (1.75 mg/kg bw) or saline vehicle and then intranasally instilled 2 h later with 10(7) plaque forming unit (PFU) of reovirus, strain Lang (T1/L) or saline vehicle. At 10 days post-instillation (PI), both virus plaque-forming responses and reovirus L2 gene expression were 10-fold higher in lungs of T-2-treated mice compared to controls. No-effect and lowest-effect levels for T-2-induced suppression of reovirus clearance were 20 and 200 microg/kg bw, respectively. Respiratory reovirus infection resulted in a mild bronchiolitis with minimal alveolitis, which was markedly exacerbated by T-2 pretreatment. Reovirus exposure induced marked increases in total cells, neutrophils and lymphocytes at 3 and 7 days PI in bronchial alveolar lavage fluid (BALF) whereas macrophages were increased only at 7 days PI. Although prior T-2 exposure attenuated total cell and macrophage counts in BALF of control and infected mice at 3 days PI, the toxin potentiated total cell, macrophage, neutrophil and lymphocyte counts in infected mice at 7 days PI. At 3 days PI, T-2 suppressed reovirus-induced IFN-gamma elevation in BALF, but enhanced production of IL-6 and MCP-1. T-2 pretreatment also suppressed reovirus-specific mucosal IgA responses in lung and enteric tract, but potentiated serum IgA and IgG responses. Taken together, T-2 increased lung viral burden, bronchopneumonia and pulmonary cellular infiltration in reovirus-infected mice. These effects might be attributable to reduced alveolar macrophage levels as well as modulated cytokine and mucosal Ig responses.

  10. T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis

    International Nuclear Information System (INIS)

    Exposure to immunosuppressive environmental contaminants is a possible contributing factor to increased occurrence of viral respiratory diseases. The objective of this study was to test the hypothesis that the trichothecene mycotoxin T-2 toxin (T-2), a frequent food contaminant, alters host resistance to lung infection by reovirus, a model respiratory virus. Balb/c mice (4 week old) were treated intraperitoneally with T-2 toxin (1.75 mg/kg bw) or saline vehicle and then intranasally instilled 2 h later with 107 plaque forming unit (PFU) of reovirus, strain Lang (T1/L) or saline vehicle. At 10 days post-instillation (PI), both virus plaque-forming responses and reovirus L2 gene expression were 10-fold higher in lungs of T-2-treated mice compared to controls. No-effect and lowest-effect levels for T-2-induced suppression of reovirus clearance were 20 and 200 μg/kg bw, respectively. Respiratory reovirus infection resulted in a mild bronchiolitis with minimal alveolitis, which was markedly exacerbated by T-2 pretreatment. Reovirus exposure induced marked increases in total cells, neutrophils and lymphocytes at 3 and 7 days PI in bronchial alveolar lavage fluid (BALF) whereas macrophages were increased only at 7 days PI. Although prior T-2 exposure attenuated total cell and macrophage counts in BALF of control and infected mice at 3 days PI, the toxin potentiated total cell, macrophage, neutrophil and lymphocyte counts in infected mice at 7 days PI. At 3 days PI, T-2 suppressed reovirus-induced IFN-γ elevation in BALF, but enhanced production of IL-6 and MCP-1. T-2 pretreatment also suppressed reovirus-specific mucosal IgA responses in lung and enteric tract, but potentiated serum IgA and IgG responses. Taken together, T-2 increased lung viral burden, bronchopneumonia and pulmonary cellular infiltration in reovirus-infected mice. These effects might be attributable to reduced alveolar macrophage levels as well as modulated cytokine and mucosal Ig responses

  11. Bronquiolite aguda, uma revisão atualizada Acute bronchiolitis, an updated review

    Directory of Open Access Journals (Sweden)

    Werther Brunow de Carvalho

    2007-04-01

    Full Text Available A bronquiolite aguda (BA é um diagnóstico freqüente de internação hospitalar em pediatria, ocasionada principalmente pelo vírus sincicial respiratório (VSR. Ocorre epidemicamente nos meses de outono e inverno. Algumas populações de crianças (recém-nascidos pré-termo, cardiopatia congênita, doença pulmonar crônica, imunocomprometidos, desnutridos, entre outros apresentam maior risco de morbidade e mortalidade. Os vírus multiplicam-se nas células epiteliais ciliadas, e a inflamação e os debris celulares ocasionam obstrução da via aérea, hiperinsuflação, atelectasia localizada, chiado e alterações das trocas gasosas. Não existem evidências definitivas em relação aos tratamentos utilizados para esta doença. O tratamento inclui a utilização de oxigênio, hidratação, beta-2 agonistas por via inalatória, epinefrina racêmica, DNase recombinante, fisioterapia respiratória, entre outros. Medidas profiláticas: administração de anticorpos monoclonais (palivizumab. A maioria das crianças com BA, independentemente da gravidade da doença, recuperam-se sem seqüelas. O curso natural desta doença, habitualmente, varia entre sete a dez dias, mas algumas crianças permanecem doentes por semanas.Acute bronchiolitis (AB is a frequent cause of hospitalization among children and its main etiological agent is respiratory syncytial virus (RSV. It occurs epidemically during autumn and winter. Some populations of children such as premature newborns, infants with congenital heart disease and those with chronic lung disease, immunocompromised, undernourished, among others, present increased morbidity and mortality risk. The virus multiplies in epithelial ciliated cells while inflammation and cellular debris cause obstruction of the airways, hyperinflation, atelectasis, and wheezing and gas exchange imbalance. Definitive evidence still does not exist about treatment of this disease, Treatment includes oxygen therapy, hydration

  12. An international ISHLT/ATS/ERS clinical practice guideline:

    DEFF Research Database (Denmark)

    Meyer, Keith C; Raghu, Ganesh; Verleden, Geert M;

    2014-01-01

    Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that is associated with poor survival. The International Society for Heart and Lung Transplantation, American Thoracic Society, and European Respiratory Society convened a committee of international experts...

  13. A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol

    Institute of Scientific and Technical Information of China (English)

    Xiao-Wei Ma; Xiao-Hui Guo; Xin-Hua Xiao; Li-Xin Guo; Xiao-Feng Lv; Quan-Min Li; Yan Gao

    2012-01-01

    Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks. Results Of the 200 randomized patients, 165 for per-protocol and 160 for the safety (QTc intervals) were set, respectively. Probucol significantly reduced total cholesterol (P < 0.001), low-density lipoprotein cholesterol (LDL-C), (P = 0.01), and high-density lipoprotein cholesterol (HDL-C) (P < 0.001) compared with conventional therapy. Cilostazol was effective in increasing HDL-C (P = 0.002) and reducing triglycerides levels (P < 0.01) compared with conventional therapy. A trend towards significance was observed for the difference between conventional therapy alone and Probucol plus Cilostazol group for the change in oxidized low-density lipoprotein (Ox-LDL, P = 0.065). No significant effects on the majority of the remaining biomarkers were found across the treatment groups. Conclusions We have confirmed that Ox-LDL could be a possible plasma atherosclerotic biomarker among the evaluated biomarkers, which reflected the synergetic effect of Cilostazol plus Probucol in patients with T2DM and ASO shown previously in preclinical studies.

  14. Usefulness of preoperative coronary angiography and brain computed tomography in cases of coronary artery disease and cerebrovascular disease undergoing revascularization for arteriosclerosis obliterans

    Energy Technology Data Exchange (ETDEWEB)

    Sakurada, Tall; Shibata, Yoshiki [Southern Tohoku Fukushima Hospital (Japan)

    2003-05-01

    Coronary angiography and brain computed tomography were preoperatively performed to evaluate the clinical condition of coronary artery disease and cerebrovascular disease in 101 patients (mean age, 68.4 years) with revascularization for arteriosclerosis obliterans. Eighty patients had hypertension, 12 had diabetes, and 26 had hyperlipidemia. Seventy-one patients (70.3%) had coronary stenosis. Significant stenoses in major coronary artery branches were confirmed in 35 patients, including 13 patients with old myocardial infarction. Coronary artery bypass grafting and percutaneous coronary angioplasty were performed in 2 and 7 patients with critical stenosis, respectively. Of 57 patients, who underwent brain computed tomography, abnormalities were found in 52 patients (91.2%), including cortical infarction in 9, lacunar infarction in 35, and leukoaraiosis in 27 patients. During the follow-up period 13 patients died (including 3 cases of myocardial infarction and 3 cases of stroke). Actuarial survival rate at 5 years was 80.4%. The influence of ischemic heart disease and cerebrovascular disease on early and late mortality after surgical reconstruction for peripheral occlusive vascular disease is significant. Using visual diagnostic techniques, such as coronary angiography and brain computed tomography, long term survivor should be closely observed for multiple arteriosclerotic vascular diseases. (author)

  15. Cerebrovascular diseases in patients with arteriosclerotic aortic aneurysm and arteriosclerosis obliterans studied by carotid ultrasonography and by computed tomography of the brain

    International Nuclear Information System (INIS)

    To estimate the incidence of cerebrovascular diseases in arteriosclerotic aortic aneurysm (AA) and arteriosclerosis obliterans (ASO) and their characteristics, 92 patients with AA and 102 patients with ASO were studied with carotid ultrasonography and brain computed tomography (CT), and were compared with 49 patients with hypertension. The mean ages of the patients were 70 to 72 years old and all were male. Hypertension was common in the AA group; diabetes and cigarette smoking were common in the ASO group. Carotid plaque lesions seen on ultrasonography were significantly more common in the AA (66%) and ASO (85%) groups than in the patients with hypertension (39%). The mean carotid diameter was significantly greater in the AA group than in the other two groups. The mean wall thicknesses in the AA and ASO groups were greater than in the patients with hypertension. Computed tomography showed that low-density areas were also common in the AA group (56%) and ASO (53%) groups than in the patients with hypertension (24%). Most of the low-density areas were thought to be lacunae or dilated perivascular spaces in the subinsula and putamen. Moderately and highly severe periventricular lucencies were also common in the AA group. These findings indicate that carotid changes, seen in AA and ASO, reflected the characteristics of arterial lesions, and that arteriosclerotic lesions were common in patients with AA and ASO. Therefore, cerebrovascular diseases should be taken into account in the management of patients with AA and ASO. (author)

  16. Cerebrovascular diseases in patients with arteriosclerotic aortic aneurysm and arteriosclerosis obliterans studied by carotid ultrasonography and by computed tomography of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Iwamoto, Toshihiko; Sugiyama, Tsuyoshi; Oyama, Tetsuo; Takasaki, Masaru [Tokyo Medical Coll. (Japan)

    1998-09-01

    To estimate the incidence of cerebrovascular diseases in arteriosclerotic aortic aneurysm (AA) and arteriosclerosis obliterans (ASO) and their characteristics, 92 patients with AA and 102 patients with ASO were studied with carotid ultrasonography and brain computed tomography (CT), and were compared with 49 patients with hypertension. The mean ages of the patients were 70 to 72 years old and all were male. Hypertension was common in the AA group; diabetes and cigarette smoking were common in the ASO group. Carotid plaque lesions seen on ultrasonography were significantly more common in the AA (66%) and ASO (85%) groups than in the patients with hypertension (39%). The mean carotid diameter was significantly greater in the AA group than in the other two groups. The mean wall thicknesses in the AA and ASO groups were greater than in the patients with hypertension. Computed tomography showed that low-density areas were also common in the AA group (56%) and ASO (53%) groups than in the patients with hypertension (24%). Most of the low-density areas were thought to be lacunae or dilated perivascular spaces in the subinsula and putamen. Moderately and highly severe periventricular lucencies were also common in the AA group. These findings indicate that carotid changes, seen in AA and ASO, reflected the characteristics of arterial lesions, and that arteriosclerotic lesions were common in patients with AA and ASO. Therefore, cerebrovascular diseases should be taken into account in the management of patients with AA and ASO. (author)

  17. Usefulness of preoperative coronary angiography and brain computed tomography in cases of coronary artery disease and cerebrovascular disease undergoing revascularization for arteriosclerosis obliterans

    International Nuclear Information System (INIS)

    Coronary angiography and brain computed tomography were preoperatively performed to evaluate the clinical condition of coronary artery disease and cerebrovascular disease in 101 patients (mean age, 68.4 years) with revascularization for arteriosclerosis obliterans. Eighty patients had hypertension, 12 had diabetes, and 26 had hyperlipidemia. Seventy-one patients (70.3%) had coronary stenosis. Significant stenoses in major coronary artery branches were confirmed in 35 patients, including 13 patients with old myocardial infarction. Coronary artery bypass grafting and percutaneous coronary angioplasty were performed in 2 and 7 patients with critical stenosis, respectively. Of 57 patients, who underwent brain computed tomography, abnormalities were found in 52 patients (91.2%), including cortical infarction in 9, lacunar infarction in 35, and leukoaraiosis in 27 patients. During the follow-up period 13 patients died (including 3 cases of myocardial infarction and 3 cases of stroke). Actuarial survival rate at 5 years was 80.4%. The influence of ischemic heart disease and cerebrovascular disease on early and late mortality after surgical reconstruction for peripheral occlusive vascular disease is significant. Using visual diagnostic techniques, such as coronary angiography and brain computed tomography, long term survivor should be closely observed for multiple arteriosclerotic vascular diseases. (author)

  18. Organizations

    DEFF Research Database (Denmark)

    Hatch, Mary Jo

    Most of us recognize that organizations are everywhere. You meet them on every street corner in the form of families and shops, study in them, work for them, buy from them, pay taxes to them. But have you given much thought to where they came from, what they are today, and what they might become...... and considers many more. Mary Jo Hatch introduces the concept of organizations by presenting definitions and ideas drawn from the a variety of subject areas including the physical sciences, economics, sociology, psychology, anthropology, literature, and the visual and performing arts. Drawing on examples from...... prehistory and everyday life, from the animal kingdom as well as from business, government, and other formal organizations, Hatch provides a lively and thought provoking introduction to the process of organization....

  19. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis

    Directory of Open Access Journals (Sweden)

    Outi E. Päiväniemi

    2009-01-01

    Full Text Available The local immunoreactivity of C-reactive protein (CRP was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB. Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P<.0001 and fibroblasts (P=.02 resulted in occlusion of the bronchial lumens (P<.01. Influx of CD4+ (P<.001 and CD8+ (P<.0001 cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P<.01, in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R=0.456–0.879, P< .05−P<.0001. Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05. During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.

  20. Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study

    Directory of Open Access Journals (Sweden)

    Harsh V Gupta

    2016-01-01

    Full Text Available Objective: To compare the effects of 3% hypertonic saline (HS and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. Materials and Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis. Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3rd day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000. The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001. Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner.

  1. Effectiveness of 3% hypertonic saline nebulization in acute bronchiolitis among Indian children: A quasi-experimental study

    Science.gov (United States)

    Gupta, Harsh V.; Gupta, Vivek V.; Kaur, Gurmeet; Baidwan, Amitoz S.; George, Pardeep P.; Shah, Jay C.; Shinde, Kushal; Malik, Ruku; Chitkara, Neha; Bajaj, Krushnan V.

    2016-01-01

    Objective: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. Materials and Methods: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis. Results: The mean ages of the patients in three groups were 6.03 ± 3.71, 5.69 ± 3.34 and 5.48 ± 3.35 respectively. The 3rd day CS scores for all the groups were 1.0 ± 1.1, 1.9 ± 1.1 and 3.3 ± 0.5 respectively (P = 0.000). The average length of hospital stay was 3.4 ± 1.7, 3.7 ± 1.9 and 4.9 ± 1.4 days respectively (P = 0.001). Conclusion: The present study concludes that 3% HS nebulization (without additional bronchodilators) is an effective and safe treatment for nonasthmatic, moderately ill patients of acute bronchiolitis. The economic benefit of this comparably priced modality of treatment can be enormous in terms of hospital costs with parents returning to work sooner. PMID:27141475

  2. 毛细支气管炎患儿微量元素的相关性研究%Trace Elements in Children with Bronchiolitis Correlation

    Institute of Scientific and Technical Information of China (English)

    苏绍斌

    2011-01-01

    Objective: Children with bronchiolitis by measuring the trace elements zinc,iron,copper, calcium,magnesium, lead content in order to understand the existence of bronchiolitis micronutrient deficiencies. Methods: To infants under 2 years old were divided into two groups: 60 patients with bronchiolitis group and 60 healthy control group. Bronchiolitis group were measured and the control group of zinc, iron, copper, calcium, magnesium, lead content and compared. Results: Bronchiolitis group of zinc, iron and calcium content is lower than the healthy group, two groups were significantly different. The two groups of trace elements copper, magnesium, lead, there was no significant difference in the content. Tip bronchiolotis lack of trace elements zinc, iron, calcium. Conclusions: By deficient in zinc,calcium treatment of bronchiolitis in children can significantly eliminate the clinical signs and symptoms, shorten the course and hospital stay, lower cost of treatment in children,is safe and effective%目的:通过测定毛细支气管炎患儿微量元素锌、铁、铜、钙、镁、铅的含量以了解毛支患儿是否存在微量元素缺乏.方法:将2岁以下的婴幼儿研究对象分为两组:60例毛支组和60例健康对照组.分别测定毛支组和对照组的微量元素锌、铁、铜、钙、镁、铅的含量并进行比较.结果:毛细支气管炎组锌、铁、钙的含量低于健康组,两组相比有显著差异.而两组的微量元素铜、镁、铅的含量则无显著差异.提示毛支患儿缺乏微量元素锌、铁、钙.结论:通过补充微量元素锌、钙治疗毛细支气管炎能显著消除患儿的临床症状和体征,缩短病程和住院时间,降低患儿治疗费用,既安全又有效.

  3. Analysis on the risk factors for severe bronchiolitis.%重型毛细支气管炎危险因素分析

    Institute of Scientific and Technical Information of China (English)

    肖红梅

    2012-01-01

    Objective To investigate the high risk factors of severe bronchiolitis in children. Methods Eighty-one children with bronchiolitis were divided into common group and severe group, according to the severity of the disease. The medical history of each case was collected, including sex, age, body weight, feeding patterns, fetal age, eczema history, and smoking history of family members. Case control analysis and statistical analysis were carried out between the two groups. Results The incidences of severe bronchiolitis were significantly higher than that of common bronchiolitis in children with male sex, premature delivery history, under 3 months old, non-breastfeeding (P0.05). Conclusion Male sex, premature delivery history, age under 3 months, and non-breastfeeding are the high risk factors of severe bronchiolitis. Careful history taking, including sex, age, delivery mode, feeding patterns, is necessary in clinical reception of children with bronchiolitis. And early-stage active intervention should be taken to prevent the occurrence of severe type bronchiolitis. Prevention of premature delivery and promoting breast feeding are the key to prevent severe bronchiolitis.%目的 探讨重型毛细支气管炎发生的高危因素.方法 将81例毛细支气管炎患儿根据病情分为普通型和重型,于病历中采集性别、年龄、体重、喂养方式、胎龄、湿疹史、家中有无经常吸烟者病史,两组比较,进行病例对照分析及统计学分析.结果 重型毛细支气管炎在男性、早产儿、年龄<3个月、非母乳喂养患儿的发生率高于普通型,两组比较差异有统计学意义(P<0.05);肥胖儿、有湿疹史和家中有经常吸烟者患儿的发生率比较差异无统计学意义(P>0.05).结论 男性、早产儿、年龄<3个月、非母乳喂养是重型毛细支气管炎发生的高危因素,接诊毛细支气管炎患儿时应仔细询问性别、年龄、出生情况和喂养方式病史特点,并进

  4. Expiratory CT scan in patients with normal inspiratory CT scan: a finding of obliterative bronchiolitis and other causes of bronchiolar obstruction

    OpenAIRE

    Gaeta, Michele; Minutoli, Fabio; Girbino, Giuseppe; Murabito, Alessandra; Benedetto, Caterina; Contiguglia, Rosario; Ruggeri, Paolo; Privitera, Salvatore

    2013-01-01

    Expiratory CT scan is usually obtained as supplement to normal inspiratory CT scan to recognize air-trapping, which is expression of small airways obstruction. In some patients the air-trapping may be the only sign of an early-stage small airways disease in an otherwise normal lung. The purpose of this article is to illustrate pathologic conditions, namely obliterative bronchiolitis, in which expiratory CT scan can be abnormal despite normal inspiratory CT examination, and to highlight indica...

  5. The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study

    OpenAIRE

    Monika Jevšnik; Andrej Steyer; Marko Pokorn; Tatjana Mrvič; Štefan Grosek; Franc Strle; Lara Lusa; Miroslav Petrovec

    2016-01-01

    Human coronaviruses (HCoVs) are associated with a variety of clinical presentations in children, but their role in disease remains uncertain. The objective of our prospective study was to investigate HCoVs associations with various clinical presentations in hospitalized children up to 6 years of age. Children hospitalized with acute bronchiolitis (AB), acute gastroenteritis (AGE), or febrile seizures (FS), and children admitted for elective surgical procedures (healthy controls) were included...

  6. Study on Effectiveness of Low Dose Theophylline as Add-on to Inhaled Corticosteroid for Patients with Sulfur Mustard Induced Bronchiolitis

    OpenAIRE

    Yunes Panahi; Zohreh Poursaleh; Ali Amini-Harandi; Amin Saburi; Majid Shohrati; Mostafa Ghanei

    2013-01-01

    Background: Theophylline may reverse steroid resistance and decrease inflammation in patients with chronic pulmonary disease and sulfur mustard (SM) induced bronchiolitis. This study was designed to assess the effects of low-dose theophylline on improvement of pulmonary function tests (PFTs) of SM exposed patients.Methods: In this comparative observational study, a group of SM-exposed victims during the Iraq-Iran war who were treated with oral slow releasing (SR) theophylline, salmetrol, flux...

  7. 毛细支气管炎患儿血清微量元素分析%Analysis of trace elements in the serum of children with bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    侯淑萍; 付荣

    2011-01-01

    目的:探讨血清中微量元素水平与毛细支气管炎的关系.方法:将住院的133例毛细支气管炎患儿作为观察组,同期门诊查体的120例健康儿童列为对照组,对其进行血清微量元素测定,并对两组检测结果进行统计学分析.结果:观察组患儿血清中锌含量低于健康儿童组,差异有统计学意义(P<0.05).结论:毛细支气管炎患儿锌缺乏,需及时补充.%Objective: To investigate the relationship between trace elements level in the serum and bronchiolitis patients.Methods: 133 cases of bronchiolitis children as the observation group, 120 cases of healthy children as control group, recorded the contents of serum trace elements, results of two groups were statistically analyzed.Results: The level of serum zinc of the observation group was lower than that of the control group, difference was statistically significant (P<0.05).Conclusion: Zinc in the serum of children with bronchiolitis is deficiency, needs to be supplemented.

  8. Guía clínica para el diagnóstico y cuidado de niños/adolescentes con bronquiolitis obliterante post-infecciosa, 2009 Clinical guide for diagnosis and care of children and adolescents with post-infectious bronchiolitis obliterans, 2009

    OpenAIRE

    Luis E Vega-Briceño; DANIEL ZENTENO A

    2009-01-01

    La bronquiolitis obliterante (BO) es un síndrome clínico poco frecuente en niños, caracterizado por la obstrucción crónica al flujo de aire asociado a cambios inflamatorios y distintos grados de fibrosis en la vía aérea pequeña. Si bien existen muchas etiologías, la causa más frecuente se asocia a infecciones respiratorias virales, principalmente adenovirus. No existe un consenso para establecer su diagnóstico; sin embargo, se considera un espectro de síntomas persistentes asociados a un patr...

  9. Recidiva en bronquiolitis obliterante con neumonía en organización: BOOP RELAPSE IN BRONCHOLITIS OBLITERANS ORGANIZING PNEUMONIA: BOOP

    OpenAIRE

    JUAN I. VARGAS RT.; SARA CHERNILO S.

    2003-01-01

    Las recaídas son frecuentes en la bronquiolitis obliterante con neumonía en organización (BOOP), sin embargo, existe poca información con respecto a su causa. Se presenta el caso de una mujer de 63 años con un cuadro clínico radiológico compatible con BOOP. No se identificó una causa subyacente por lo que se planteó el diagnóstico de neumonía en organización criptogénica o COP. Se realizaron biopsias transbronquiales que demostraron una neumonía crónica organizada y bronquiolitis proliferativ...

  10. Lung structure-respiratory function relationships in experimentally-induced bronchiolitis, bronchopneumonia and interstitial pneumonia in rats

    International Nuclear Information System (INIS)

    Histopathology and respiratory function of rats with three different types and distributions of lower lung inflammation were compared to better understand lung structure-function relationships. Rats were exposed 21 h/day for 7 days to 0.8 ppm ozone (O3), sham-exposed as controls, or given 5 mg/kg bacterial endotoxin either intratracheally (ITE) or intraperitoneally (IPE). Respiratory function was measured 24 h after the end of treatment, than the rats were sacrificed and the distribution of inflammation was evaluated morphometrically. Chronic centriacinar inflammation with formation of new respiratory bronchioles caused an obstructive functional impairment in the O3 rats, which was clearly distinguished from the restrictive impairments resulting from acute inflammation in ITE and IPE rats. Only the magnitudes of changes related to the distribution of inflammation differentiated the ITE and IPE groups. Flow parameters previously thought sensitive to large airway resistance were changed in the O3 rats. Alveolar luminal inflammatory exudate affected quasistatic compliance more than septal inflammation in ITE and IPE rats. Quasistatic chord compliance was the most sensitive of three indices of pressure-volume relationships. The findings in this study improve the basis for interpreting respiratory function changes of rats. (author)

  11. 雾化吸入治疗小儿毛细支气管炎的护理研究进展%A research progress on nursing for aerosol inhalation in the treatment of children with bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈领; 陈素娟

    2016-01-01

    Bronchiolitis is a common disease in children, which usually presents runny nose, cough and shortness of breath.Severe bronchiolitis can cause dyspnea and it seriously impacts the health of children. Supportive care is the basis for the treatment of bronchiolitis.Aerosol inhalation plays an important role in the treatment of bronchiolitis.This paper will review recent inhalation therapy and nursing progress of bronchiolitis from the aspect of aerosolized medication selection and aerosolized mode, nursing intervention on inhalation.%毛细支气管炎是小儿常见病,通常表现为流涕、咳嗽和呼吸急促,严重可引起呼吸困难,严重影响患儿健康. 支持治疗是目前治疗毛细支气管炎的基础,雾化吸入对治疗小儿毛细支气管炎具有重要作用,本文将从雾化药物的选择、雾化方式的选择及雾化吸入的护理干预等方面对近年来雾化吸入治疗小儿毛细支气管炎的研究及护理进展作一综述.

  12. 动脉硬化性闭塞症患者的健康教育效果评价%Evaluation of Health Education on Patients with Arteriosclerosis Obliterans

    Institute of Scientific and Technical Information of China (English)

    李爱然

    2011-01-01

    目的 观察动脉硬化性闭塞症患者健康教育的效果.方法随机选取符合条件的动脉硬化性闭塞症患者35例,由专职人员进行健康教育,包括饮食、运动、心理等指导.结果动脉硬化性闭塞症患者接受健康教育后,知识知晓率提高了28.58%、健康教育前后经配对秩和检验,差异有统计学意义(Z=-5.716,P<0.01);遵医行为明显改善(Z=-5.333,P<0.01)、自我管理能力有所提高(Z=-2.200,P<0.05),血脂降低(Z= -3.79,P<0.01),3方面差异均有统计学意义.结论通过对动脉硬化性闭塞症患者的健康教育,增加了患者治疗的信心,减轻了症状,增强了保健意识,提高了生活质量.%[Objective]To observe the health education effect on patients with arteriosclerosis obliterans. [Methods] A total of 35 eligible patients with atherosclerotic occlusion were randomly selected who were educated about health knowledge, including diet, ex-ercice and psychological guidance, by full-time staff, [Results] After health education, awareness rate of patients with arteriosclero-sis obliterans increased by 28. 38% which was significant before and after health education by the paired Wilcoxon test (Z = -5. 716,P= 0.001). Compliance Behavior of patients had improved (Z = -5.333, P = 0.001). Self-management of patients had enhanced(Z= -2.200, P=0.028). Serum lipids of patients had reduced (Z= -3.79,P = 0.001). These differences were all significant. [ Conclusion] Health education on patients with arteriosclerosis obliterans increases their confidence in the treatment, relieves symptoms, increases their health awareness and improves their quality of life.

  13. A N UNUSUAL CASE OF SWYER - JAMES - MACLE O DS SYNDROME WITH DEXTROCARDIA

    Directory of Open Access Journals (Sweden)

    Sahana

    2015-05-01

    Full Text Available Swyer - James/MacLeod S yndrome ( SJMS is an uncommon disease with the haracteristic radiological feature of "unilateral hyperlucency" due to loss of pulmonary vasculature and air trapping . SJMS is considered to be a form of bronchiolitis obliterans that fol lows viral bronchiolitis and pneumonitis . This report describes a rare case of Swyer - James syndrome with dextrocardia diagnosed in a 3 year s old child during evaluation for recurrent respiratory infections . KEYWORDS : Swyer - James/MacLeod syndrome ; Unilateral Hyperlucency ; Bronchiolitis obliterans ; Chest X - ray ; Dextrocardia .

  14. Clinical experience of Prof. ZHAO Kun for treating bronchiolitis with Mahuang Fuzi Xixin decoction%赵坤教授运用麻黄附子细辛汤加减治疗毛细支气管炎经验

    Institute of Scientific and Technical Information of China (English)

    古华倩; 顾丽丽; 赵坤

    2014-01-01

    To investigate application of Mahuang Fuzi Xixin decoction in treating bronchiolitis. To analyze the unique advantages of TCM treatment of bronchiolitis. Professor ZHAO Kun tells:onset of bronchiolitis related with exogenous pathogenic cold, lung, spleen and kidney three dirty less closely related and should be treated with Mahuang Fuzi Xixin decoction for yang and cold-off.%探讨赵坤教授运用麻黄附子细辛汤治疗毛细支气管炎的经验。分析中医药治疗毛细支气管炎的独特优势。赵坤教授认为:毛细支气管炎的发作与外感寒邪、肺脾肾三脏不足密切相关,治疗上应予麻黄附子细辛汤温阳散寒、疏风宣肺。

  15. 重症毛细支气管炎的综合护理干预%Comprehensive Nursing Intervention of Severe Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    彭永健

    2013-01-01

    Objective: To investigate the application effect of comprehensive nursing measures of aerosol inhalation, percussion on back, postural drainage, suctioning and compression spray on children with severe bronchiolitis. Methods:We applied comprehensive nursing measures of aero-sol inhalation, percussion on back, postural drainage, suctioning and compression spray on twelve children with severe bronchiolitis and observed the nursing effect. Results:According to comprehen-sive nursing, twelve children’s respiratory rate, heart rate and arterial blood oxygen saturation were improved obviously. Conclusion:Comprehensive nursing measures of aerosol inhalation, per-cussion on back, postural drainage, suctioning and compression spray can help children with severe bronchiolitis maintain airway patency, alleviate hypoxia, live through the acute phase smoothly and discharge from hospital with recovery.%  目的:探讨雾化吸入、拍背、体位引流、吸痰、压喷等综合护理措施对重症毛细支气管炎患儿的应用效果。方法:对12例患重症毛细支气管炎的婴幼儿采取压喷吸入、胸部叩击、体位引流、吸痰等综合护理措施,观察护理效果。结果:经过综合护理后12例患儿的呼吸、心率、血氧饱和度均得到明显改善。结论:通过压喷吸入、拍背、体位引流、吸痰等综合护理措施,能有效帮助重症毛支患儿保持气道通畅,缓解缺氧,平稳度过急性期直至痊愈出院。

  16. 甲泼尼龙治疗毛细支气管炎疗效观察%Clinical observation of methylprednisolone for bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    石菊红; 方春艳

    2009-01-01

    Objective To compare the Clinical observation of Methylprednisolone (Mps) and dexamethasone in the treatment of Bronchiolitis. Methods Fifty-eight cases with bronchiolitis were randomly divided into the control group (n=29,intravenous injection of dexamethasone) and the treatment group (n=29, intravenous drip of Mps). Results The duration of pant and wheeze and cough and days in hospital were shorter in the treatment group than that in the control group .The difference was significant(P<0.01). Conclusion The Methylprednisolone is better than dexamethasone for bronchiolitis of children.%目的 比较甲泼尼龙与地塞米松治疗毛细支气管炎的疗效.方法 58例毛细支气管炎患儿随机分为两组,对照组(29例)在常规治疗基础上加用地塞米松静脉推注,治疗组(29例)在常规治疗基础上加用甲泼尼龙静脉滴注.结果 治疗组喘息消失、咳嗽消失、肺部啰音消失时间及住院时间均较对照组缩短,差异有统计学意义(P<0.01).结论 甲泼尼龙治疗毛细支气管炎疗效优于地塞米松.

  17. 毛细支气管炎与哮喘相关性的研究进展%Research Progress on Association of Bronchiolitis with Asthma

    Institute of Scientific and Technical Information of China (English)

    刘晓梅

    2011-01-01

    Asthma is the most common chronic airway inflammatory disease that threatens the public health worldwide. Bronchiolitis manifests mainly as wheezing in childhood and is likely to progress into asthma. A long-term follow-up study shows that pediatric patients with bronchiolitis have a 22.1%~ 53. 2% of likelihood to suffer from asthma , significantly higher than that in normal children. The two major wheezing disorders in childhood are associated in some way. Extensive studies show that the progression of bronchiolitis into asthma depends on a variety of factors, including genetics , immunity , infection , environmental factors, susceptibility , and feeding. This article reviews the potential associations in the sense of genetics , immunity , and infection.%哮喘是当今世界威胁公共健康最常见的呼吸道慢性炎症性疾病.毛细支气管炎是婴幼儿时期以喘憋为突出临床表现的疾病,患儿易于病后发生哮喘,长期随访观察22.1% ~53.2%患哮喘,明显高于正常儿童.作为婴幼儿时期两个重要的喘息性疾病存在一定的相关性,研究显示毛细支气管炎发展为哮喘与遗传、免疫、感染、环境影响、特应质、喂养方式等诸多因素有关.现仅从遗传、免疫、感染等方面阐述其可能存在的相关性.

  18. 定喘汤治疗毛细支气管炎临床研究%Clinical research on treating bronchiolitis with the asthma-reliving decoction

    Institute of Scientific and Technical Information of China (English)

    王志敏

    2012-01-01

      Objective: To research the clinical effect of asthma-reliving decoction in treating bronchiolitis. Methods: 66 cases of children with bronchiolitis were randomly divided into the treatment group and the control group, 33 cases in each group. The treatment group was given the asthma-reliving decoction for oral use on the basis of western medicine, while the control group was given only western medicine for anti-infection and symptomatic treatment. Compared the pyretolysis time, tussis extinction time, pulmonary rales extinction time and the total efficiency between the two groups. Results: Compared with the control group, the pyretolysis time, tussis extinction time, pulmonary rales extinction time and the total efficiency of the treatment group had significant difference (P<0.05). Conclusion: The asthma-reliving decoction was effective in treating bronchiolitis.%  目的:研究定喘汤治疗毛细支气管炎临床疗效.方法:66例毛细支气管炎患者随机分为治疗组和对照组各33例,对照组用西药抗感染及对症治疗,治疗组在对照组用药的基础上加中药定喘汤口服,对比两组退热时间、咳嗽消失时间、肺部啰音消失时间及综合疗效.结果:治疗组退热时间、咳嗽消失时间、肺部罗音消失时间及总有效率与对照组相比差异有统计学意义(P<0.05).结论:定喘汤治疗毛细支气管炎效果确切.

  19. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis

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    Britton John

    2011-01-01

    Full Text Available Abstract Background Passive smoke exposure increases the risk of lower respiratory infection (LRI in infants, but the extensive literature on this association has not been systematically reviewed for nearly ten years. The aim of this paper is to provide an updated systematic review and meta-analysis of studies of the association between passive smoking and LRI, and with diagnostic subcategories including bronchiolitis, in infants aged two years and under. Methods We searched MEDLINE and EMBASE (to November 2010, reference lists from publications and abstracts from major conference proceedings to identify all relevant publications. Random effect pooled odds ratios (OR with 95% confidence intervals (CI were estimated. Results We identified 60 studies suitable for inclusion in the meta-analysis. Smoking by either parent or other household members significantly increased the risk of LRI; odds ratios (OR were 1.22 (95% CI 1.10 to 1.35 for paternal smoking, 1.62 (95% CI 1.38 to 1.89 if both parents smoked, and 1.54 (95% CI 1.40 to 1.69 for any household member smoking. Pre-natal maternal smoking (OR 1.24, 95% CI 1.11 to 1.38 had a weaker effect than post-natal smoking (OR 1.58, 95% CI 1.45 to 1.73. The strongest effect was on bronchiolitis, where the risk of any household smoking was increased by an OR of 2.51 (95% CI 1.96 to 3.21. Conclusions Passive smoking in the family home is a major influence on the risk of LRI in infants, and especially on bronchiolitis. Risk is particularly strong in relation to post-natal maternal smoking. Strategies to prevent passive smoke exposure in young children are an urgent public and child health priority.

  20. Mixed Herbal Medicine Induced Diffuse Infiltrative Lung Disease: The HRCT and Histopathologic Findings

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the high-resolution CT (HRCT) and pathologic findings of mixed herbal medicine-induced diffuse interstitial lung disease. Eight patients (6 women and 2 men, age range: 31 to 81 years, mean age: 51.4 years) who presented with cough or dyspnea after taking mixed herbal medicine were included in this study. All the patients underwent plain chest radiography and HRCT. We obtained pathologic specimens from 7 patients via fluoroscopy guided large bore cutting needle biopsy and transbronchial lung biopsy. All the patients were treated with steroid therapy. The most common HRCT finding was bilateral diffuse ground glass opacity (n=7), followed by peribronchial consolidation (n=5) and inter- or intralobular septal thickening (n=2). For the disease distribution, the lower lung zone was dominantly involved. The pathologic results of 7 patients were nonspecific interstitial pneumonia (n=3), bronchiolitis obliterans organizing pneumonia (n=2), hypersensitivity pneumonitis (n=1) and eosinophilic pneumonia (n=1). Irrespective of the pathologic results, all 8 patients improved clinically and radiologically after steroid treatment. The HRCT findings of mixed herbal medicine-induced diffuse infiltrative lung disease were mainly bilateral diffuse ground glass opacity, peribronchial consolidation and dominant involvement of the lower lung zone. Those pathologic findings were nonspecific and the differential diagnosis could include interstitial pneumonia, bronchiolitis obliterans organizing pneumonia, hypersensitivity pneumonitis and eosinophilic pneumonia

  1. Mixed Herbal Medicine Induced Diffuse Infiltrative Lung Disease: The HRCT and Histopathologic Findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Gyu; Shin, Eun A [Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of); Kim, Joung Sook [Mokdong Hospital, Ewha Womans University College of Medicine, Seoul (Korea, Republic of)

    2010-12-15

    The purpose of this study was to evaluate the high-resolution CT (HRCT) and pathologic findings of mixed herbal medicine-induced diffuse interstitial lung disease. Eight patients (6 women and 2 men, age range: 31 to 81 years, mean age: 51.4 years) who presented with cough or dyspnea after taking mixed herbal medicine were included in this study. All the patients underwent plain chest radiography and HRCT. We obtained pathologic specimens from 7 patients via fluoroscopy guided large bore cutting needle biopsy and transbronchial lung biopsy. All the patients were treated with steroid therapy. The most common HRCT finding was bilateral diffuse ground glass opacity (n=7), followed by peribronchial consolidation (n=5) and inter- or intralobular septal thickening (n=2). For the disease distribution, the lower lung zone was dominantly involved. The pathologic results of 7 patients were nonspecific interstitial pneumonia (n=3), bronchiolitis obliterans organizing pneumonia (n=2), hypersensitivity pneumonitis (n=1) and eosinophilic pneumonia (n=1). Irrespective of the pathologic results, all 8 patients improved clinically and radiologically after steroid treatment. The HRCT findings of mixed herbal medicine-induced diffuse infiltrative lung disease were mainly bilateral diffuse ground glass opacity, peribronchial consolidation and dominant involvement of the lower lung zone. Those pathologic findings were nonspecific and the differential diagnosis could include interstitial pneumonia, bronchiolitis obliterans organizing pneumonia, hypersensitivity pneumonitis and eosinophilic pneumonia

  2. Food intake during the previous 24 h as a percentage of usual intake: a marker of hypoxia in infants with bronchiolitis: an observational, prospective, multicenter study

    Directory of Open Access Journals (Sweden)

    Corrard François

    2013-01-01

    Full Text Available Abstract Background Hypoxia associated with bronchiolitis is not always easy to assess on clinical grounds alone. The aim of this study was to determine the value of food intake during the previous 24 hours (bottle and spoon feeding, as a percentage of usual intake (24h FI, as a marker of hypoxia, and to compare its diagnostic value with that of usual clinical signs. Methods In this observational, prospective, multicenter study, 18 community pediatricians, enrolled 171 infants, aged from 0 to 6 months, with bronchiolitis (rhinorrhea + dyspnea + cough + expiratory sounds. Infants with risk factors (history of prematurity, chronic heart or lung disorders, breast-fed infants, and infants having previously been treated for bronchial disorders were excluded. The 24h FI, subcostal, intercostal, supracostal retractions, nasal flaring, respiratory rate, pauses, cyanosis, rectal temperature and respiratory syncytial virus test results were noted. The highest stable value of transcutaneous oxygen saturation (SpO2 was recorded. Hypoxia was noted if SpO2 was below 95% and verified. Results 24h FI ≥ 50% was associated with a 96% likelihood of SpO2 ≥ 95% [95% CI, 91–99]. In univariate analysis, 24h FI  Conclusion In practice, the measure of 24 h FI may be useful in identifying hypoxia and deserves further study.

  3. 维生素D与毛细支气管炎的研究进展%Advances in correlation of vitamin D and bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    涂李娟; 赵力芳; 庞随军

    2015-01-01

    Traditional physiological role of vitamin D is to maintain the normal growth and development of human tissue cells .Vitamin D deficiency can reduce the absorption and usage of cal-cium and risk of suffering from rickets ,osteomalacia disease ,ect.Recently, the study of vitamin D and bronchiolitis is becoming more and more , studies have shown that vitamin D treatment of bron-chiolitis have certain effect and can reduce the onset of wheezing in the future .%维生素D的传统生理作用是维持人体组织细胞的正常生长发育,其缺乏会导致人体钙元素的吸收及利用率的降低,严重时可导致儿童佝偻病、骨软化症的发生。随着人们对维生素D作用的进一步研究发现,维生素D对毛细支气管炎有一定的治疗作用,并能减少日后喘息发作。

  4. 持续正压通气在重症毛细支气管炎中的应用%The clinical application of continuous positive airway pressure in severe bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    史瑞鹤; 刘恩梅

    2015-01-01

    毛细支气管炎是小婴儿最常见的下呼吸道感染性疾病,目前尚无特异性治疗,主要以对症支持治疗为主,近年来其治疗方法的探索一直是临床热点。持续正压通气(CPAP)作为一种安全、有效、无创的治疗方法,能有效缓解毛细支气管炎患儿的症状,改善预后,其临床应用越来越受到重视。文章对持续正压通气在重症毛细支气管炎患儿中的临床应用进行综述。%Bronchiolitis is the most common lower respiratory tract disease in infants. There is no speciifc treatment for it and the treatment is mainly supportive. The management of bronchiolitis is the clinical hotspot recently. Continuous positive airway pressure (CPAP) has gained more attention in clinical application as it is a safe, effective, and noninvasive method and can effectively relieve symptoms of bronchiolitis and improve prognosis. This paper reviews the clinical application of CPAP in infants with severe bronchiolitis.

  5. 100 cases Bronchiolitis Hypercoagulable State and the Effectiveness of Heparin Therapy%毛细支气管炎合并高凝状态100例及肝素抗凝治疗的有效性研究

    Institute of Scientific and Technical Information of China (English)

    胡敏

    2013-01-01

    目的探讨毛细支气管炎合并高凝状态及肝素抗凝治疗的有效性。方法测定2011年10月~2012年6月四川省简阳市中医院儿科收治的100例毛细支气管炎患儿治疗前后的D-二聚体(D-Dimer)、抗凝血酶Ⅲ(AT-Ⅲ)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血时间(APTT)、纤维蛋白原(Fbg)及氧饱和度(SaO2),并进行对比。结果100例毛细支气管炎患儿中50例的D-Dimer升高,治疗前50例患儿的AT-Ⅲ活性及SaO2明显降低,TT、APTT明显缩短。经肝素治疗后,50例治疗组患儿的D-Dmuer下降、SaO2升高、TT延长、Fbg下降。结论毛细支气管炎存在高凝状态;肝素抗凝治疗对毛细支气管炎合并高凝状态是有效的。%Objective To explore the hypercoagulable state of bronchiolitis and the ef ective anticoagulation treatment with heparin. Method D-Dimer、AT-Ⅲ、TT、PT、APTT、 Fbg and SaO2 levels were measured and compared in bronchiolitis before and after treatment with heparin. Results D-Dimer level was increased in 50 of 100 cases of bronchiolitis patients. In 50 patients with bronchiolitis before treatment with heparin, AT-Ⅲ And SaO2 levels were significantly lower and TT、APTT were remarkably shorter than in normal group. In 50 patients with bronchiolitis after treatment with heparin, D-Dimer and Fbg levels were significantly reduced, while SaO2 and TT levels were obviously increased. Conclusions There exists hypercoagulable state in bronchiolitis; Anticoagulation treatment with heparin in hypercoagulable state of bronchiolitis were ef ective.

  6. 血清CysLTs在毛细支气管炎和哮喘中的作用%Serum CysLTs in the Role of Bronchiolitis and Asthma

    Institute of Scientific and Technical Information of China (English)

    夏明月; 孙莉; 李明丽; 马瑞

    2013-01-01

    Objective:To explore the function and significance of CysLTs serum expression in bronchiolitis and asthma. Methods:80 cases of bronchiolitis children (bronchiolitis group) and 80 children with asthma (asthma group) were randomly selected. 40 healthy children served as control group. The levels of serum CysLTs in al groups were detected by enzyme-linked imnmnosorbent assays (ELISA). One-way ANOVA and T-test were performed to test the dif erence among the 3 groups. Results the serum CysLTs levels of children at acute stage of bronchiolitis and asthma group were higher than those of healthy children (P0.05). In remission period the serum CysLTs levels of bronchiolitis group were lower than that of asthma group (P0.05). The serum levels of asthma group were higher than that of control group (P0.05),均明显高于对照组(P0.05);哮喘组缓解期血清CysLTs水平高于健康对照组(P<0.05)。结论 CysLTs参与了毛支和哮喘的病理过程,但毛支恢复期血清CysLTs水平低于哮喘缓解期接近正常,揭示毛支不同于哮喘存在长期的气道过敏性炎症,故恢复期血清CysLTs水平,可以作为预测毛细支气管炎患儿以后发展为哮喘可能性的指标。

  7. 毛细支气管炎演变为哮喘的相关因素研究%Studies of the influences of bronchiolitis on development of asthma

    Institute of Scientific and Technical Information of China (English)

    朱丽丽

    2012-01-01

    哮喘是威胁儿童健康最常见的慢性气道炎症性疾病之一.毛细支气管炎显著增加了儿童哮 喘的发病风险,研究毛细支气管炎向哮喘发展的相关因素是近年研究热点,它有助于深入认识哮喘发生、发展的机制,为哮喘提供新的防治措施.目前研究认为,毛细支气管炎在遗传学、免疫学、环境因素(如病毒感染)等方面影响着哮喘的发展,而毛细支气管炎是否直接导致儿童哮喘的发展,通过预防毛细支气管炎能否降低儿童哮喘的发病率仍有待进一步研究.%Asthma is one of the most chronic airway inflammatory disease,threating the children's health.Bronchiolitis significantly increased the risk of childhood asthma,and many studies have focused on looking for the related factors between bronchiolitis and asthma in recent years.It may be helpful to understand the pathogenesis of the asthma,so as to find new measures for asthma's prevention and treatment.In present studies,bronchiolitis influenced the development of asthma in genetics,immunity,environmental factors and so on.So far,whether bronchiolitis directly causes the development of the childhood asthma,the prevention of bronchiolitis could reduce the asthma morbidity or not,both need more evidences yet.

  8. Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: Causes, CT-follow up and patient outcome

    International Nuclear Information System (INIS)

    Objective: The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods: Patients with evidence of thoracic air-leakage, i.e. spontaneous pneumomediastinum, spontaneous pneumothorax or interstitial emphysema after allo-HCT were retrospectively identified by a chart review. Acute and follow-up morphology, duration and patient outcome were analyzed on CT (HRCT or MSCT with HR-reconstructions). Correlation was made with histological results of transbronchial biopsy. Results: The 6 patients included (3 male and 3 female, 14-64 years old) with thoracic air-leakage after allo-HCT all had histologically proven bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP). Thoracic air-leakage consisted of spontaneous pneumomediastinum associated with active invasive pulmonary aspergillosis (IPA) in 4/6 and spontaneous pneumothorax or interstitial emphysema each in 1/6 patients. Duration of thoracic air-leakage was 7-135 days. Of the patients with spontaneous pneumomediastinum, 3/4 died of IPA. One patient survived until complete regression of spontaneous pneumomediastinum. One patient died 7 days after spontaneous pneumothorax and one survived developing chronic interstitial emphysema. Conclusion: In all cases, thoracic air-leakage was associated to BO or BOOP. In the majority of cases with additional IPA, thoracic air-leakage is more indicative for severity of pulmonary disease than a life-threatening entity itself

  9. Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: Causes, CT-follow up and patient outcome

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Monika [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)]. E-mail: monika.vogel@med.uni-tuebingen.de; Brodoefel, Harald [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Bethge, Wolfgang [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Faul, Christoph [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Hartmann, Joerg [Department of Internal Medicine-Oncology, Eberhard-Karls-University, Ottfried-Mueller-Str. 5, 72070 Tuebingen (Germany); Schimmel, Heiko [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Wehrmann, Manfred [Department of Pathology, Eberhard-Karls-University, Liebermeisterstrasse 8, 72076 Tuebingen (Germany); Claussen, Claus D. [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany); Horger, Marius [Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen (Germany)

    2006-12-15

    Objective: The purpose of this article is to describe and illustrate the acute and follow-up imaging features, clinical constellation and outcome of patients with thoracic air-leakage syndrome following allogeneic hematopoietic stem cell transplantation (allo-HCT). Methods: Patients with evidence of thoracic air-leakage, i.e. spontaneous pneumomediastinum, spontaneous pneumothorax or interstitial emphysema after allo-HCT were retrospectively identified by a chart review. Acute and follow-up morphology, duration and patient outcome were analyzed on CT (HRCT or MSCT with HR-reconstructions). Correlation was made with histological results of transbronchial biopsy. Results: The 6 patients included (3 male and 3 female, 14-64 years old) with thoracic air-leakage after allo-HCT all had histologically proven bronchiolitis obliterans (BO) or bronchiolitis obliterans organizing pneumonia (BOOP). Thoracic air-leakage consisted of spontaneous pneumomediastinum associated with active invasive pulmonary aspergillosis (IPA) in 4/6 and spontaneous pneumothorax or interstitial emphysema each in 1/6 patients. Duration of thoracic air-leakage was 7-135 days. Of the patients with spontaneous pneumomediastinum, 3/4 died of IPA. One patient survived until complete regression of spontaneous pneumomediastinum. One patient died 7 days after spontaneous pneumothorax and one survived developing chronic interstitial emphysema. Conclusion: In all cases, thoracic air-leakage was associated to BO or BOOP. In the majority of cases with additional IPA, thoracic air-leakage is more indicative for severity of pulmonary disease than a life-threatening entity itself.

  10. A COMPARATIVE STUDY TO ASSESS THE EFFE CTS OF NEBULISED 3% HYPERTONIC SALINE, 0.9% NORMAL SALINE AND SALBUTALMOL IN MANAGEMENT OF ACUTE BRONCHIOLITIS AMONG INDIAN CHILDREN

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    Gaurav

    2015-03-01

    Full Text Available AIMS AND OBJECTIVES: To compare the effects of nebulised 3% hypertonic saline , 0.9% saline and salbutamol in patients of acute bronchiolitis . DESIGN: R andomised controlled trial . SETTING: tertiary care teaching hospital . MATERIAL AND METHODS: 100 Children with age 1 to 24 months admitted in hospital with clinical diagnosis of acute bronchiolitis for 2 consecutive years were included in the study. Participants were divided into 3 groups – 3% hypertonic saline (HS , 0.9% norm al saline and salbutalmol. 4 doses of nebulisation at an interval of 6 hours were given daily in each group till discharge. RESULTS: The mean age of the patients in the study population was 5.7 ± 3.4 months. Maximum number of the patients i.e. 65.7% belong ed to the age group of 0 - 6 months. There was male preponderance in all 3 groups. Baseline Clinical Severity (CS scores in 3%HS , 0.9% Normal Saline and Salbutamol groups were 5.9±1.5 , 5.5±1.0 and 5.1±2.3 respectively (p=0.146. After treatment , the CS scor es dropped to 1.0±1.1 , 3.3±0.5 and 1.9±1.1 in 3%HS , 0.9% Normal Saline and Salbutamol groups respectively on the 3 rd day of treatment (p<0.01. Length of hospital stay in 3% HS , 0.9% Normal Saline and Salbutamol groups was 3.4±1.7 , 4.9±1.4 and 3.7±1.9 days respectively , which was found to be statistically significant (p= 0.001. CONCLUSION: 3% Hypertonic Saline nebulization (without additional bronchodilators is an effective and safe treatment in patients of acute bronchiolitis. It significantly reduces th e CS scores and length of hospital stay as compared to 0.9% Normal Saline and Salbutamol nebulizations.

  11. α-干扰素治疗毛细支气管炎疗效观察%Therapeutic Effect of IFN-αin Treating Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    苏丽霞

    2013-01-01

    Objective:To observe the therapeutic effect of interferon-α(IFN-α)on the infants with bronchiolitis. Method:64 cases with bronchiolitis were divided randomly into IFN-αtreatment group(32 cases)and control group(32 cases). Both groups got some routine treatments. The treatment group received additional intramuscular injection IFN-α[(50~100 kU/(kg·d),qd×5 d].The difference of improvement of symptoms and physical signs were observed in both groups. Result:The periods of the remission and disappearance of cough,asthma and rales were significantly shorter in the treatment group than those in the control group,The total effective rate of treatment group and control group were 91%and 81%respectively. The difference was significant(P<0.05).Conclusion:IFN-αtreatment is effective in treating bronchiolitis,and it is reliable and should be used widely.%目的:探讨α-干扰素治疗婴幼儿毛细支气管炎的临床疗效。方法:将64例毛细支气管炎患儿随机分为治疗组32例和对照组32例,对照组采用常规治疗方法,治疗组在此基础上加用α-干扰素5~10万U/(kg·d)肌肉注射,1次/d,疗程5 d。观察患儿咳嗽、喘息及肺部喘鸣音、湿啰音消退时间。结果:治疗组咳嗽、喘息及肺部体征消失时间均短于对照组,治疗组和对照组总有效率分别为91%和81%,两组比较差异均有统计学意义(P<0.05)。结论:α-干扰素治疗毛细支气管炎有确切的临床疗效,值得在临床推广使用。

  12. Study on Effectiveness of Low Dose Theophylline as Add-on to Inhaled Corticosteroid for Patients with Sulfur Mustard Induced Bronchiolitis

    Directory of Open Access Journals (Sweden)

    Yunes Panahi

    2013-12-01

    Full Text Available Background: Theophylline may reverse steroid resistance and decrease inflammation in patients with chronic pulmonary disease and sulfur mustard (SM induced bronchiolitis. This study was designed to assess the effects of low-dose theophylline on improvement of pulmonary function tests (PFTs of SM exposed patients.Methods: In this comparative observational study, a group of SM-exposed victims during the Iraq-Iran war who were treated with oral slow releasing (SR theophylline, salmetrol, fluxitide, omeprazole and NAC (study group were compared to a group of age and gender matched SM-exposed patients who received same medications except oral SR theophylline (historical control group. PFTs were measured at the beginning of the study and after 8 weeks of the treatment.Results: In total, 33 subjects in the study group and 27 subjects in the control group were studied. Mean (SD age of all subjects was 51 (14.1 years. In the study group, on the 8th week post-treatment, PFTs decreased, though the differences of tests between before and after treatment were not significant. In the control group, all the tests decreased in the same period and these reductions were not also significant. However, the changes in PFTs were significantly different between the two groups. The results of most PFTs in the controls decreased in greater extents compared to theophylline treated patients. This shows that despite theophylline was unable to improve the patients; it was partially able to decelerate the reductions in PFTs.Conclusion: Theophylline may not improve PFTs of SM exposed patients but it may decelerate the progress of the underlying respiratory disease. Further studies in this setting with higher doses of theophylline and longer term of evaluation are needed to better understand the pathophysiological mechanism of SM induced bronchiolitis and the effectiveness of the treatment with theophylline.   How to cite this article: Panahi Y, Poursaleh Z, Amini-Harandi A

  13. Evaluation of percutaneous transluminal angioplasty for treatment of infrapopliteal arteriosclerosis obliterans%经皮腔内血管成形术治疗膝下动脉粥样硬化闭塞症的评价

    Institute of Scientific and Technical Information of China (English)

    张玉超; 黄英; 李维敏; 陆信武; 黄新天; 陆民; 蒋米尔

    2012-01-01

    Objective To assess the therapeutic effect of percutaneous transluminal angioplasty ( PTA )on the treatment of infrapopliteal arteriosclerosis obliterans( ASOs ). Methods From Jan. 2007 to Jun. 2011, clinical data of patients with infrapopliteal ASO undergoing PTA at our department were retrospectively reviewed. Results Infrapopliteal PTA was performed on 138 lower limbs for 138 patients( mean age,77. 31 ±7. 52 year - old ). The mean diameter of balloon catheters used for infrapopliteal arteries was 2. 8 mm( 2 mm ~4 mm ), with the mean length of 110. 6 mm( 40 mm ~ 170 mm ). There were no severe complications occurring intraoperatively or postoperatively. Early results showed that all patients had significant improvement in ischemic symptoms( 100% ), and no patients had limb loss. During a mean follow -up of 24. 1 months( 4 ~ 58 months ), the rate of improvement in ischemic symptoms for treated limbs was 78. 4% and the limb salvage rate was 93. 9% at 2 years. Conclusion Minimal invasive PTA for the treatment of infrapopliteal ASO is safe and effective for improving ischemic symptoms of lower limbs and limb salvage.%目的 评价经皮腔内血管成形术(percutaneous transluminal angioplasty,PTA)治疗膝下动脉粥样硬化闭塞症(arteriosclerosis obliterans,ASO)的疗效.方法 回顾性研究2007年1月至2011年6月我科收治的累及膝下动脉ASO并行PTA治疗的患者的临床资料.结果 138例患者,平均年龄(77.31±7.52)岁,治疗膝下动脉所用球囊平均直径 2.8mm(2~4mm),平均长度110.6mm(40~170mm),术中及术后无严重并发症.术后早期治疗肢体临床症状明显改善率为100%,无截肢患者.平均随访24.1个月(4~58个月),治疗肢体术后2年临床症状明显改善率78.4%,救肢率93.9%.结论 PTA治疗膝下动脉ASO可有效改善临床缺血症状并提高救肢率.

  14. Bronchiolitis (For Parents)

    Science.gov (United States)

    ... Influenza (Flu) Activity: The Lungs Movie: Lungs & Respiratory System Your Lungs & Respiratory System Flu Chilling Out With Colds Coping With Colds Pneumonia Flu Facts Lungs and Respiratory System Contact Us Print Resources Send to a friend ...

  15. Analysis the Related Risk Factors for Asthma Following Bronchiolitis%小儿毛细支气管炎哮喘病因分析

    Institute of Scientific and Technical Information of China (English)

    罗艳红

    2013-01-01

    Objective:To analyze the related risk factors for asthma following bronchiolitis.Method:The clinical data of 110 patients with bronchiolitis in our hospital from August 2010 to January 2013 were analyzed retrospectively.Result:Children obesity,illness weight,family history of asthma and specific physical fitness were important in infantile capillary bronchitis asthma risk factors,and the patient’s age,gender,feeding way were not important in infantile capillary bronchitis asthma risk factors.Conclusion:Capillary bronchitis and asthma risk factors are prone to asthma,in the process of clinical treatment for control and prevention,as far as possible risk factors,which can improve the patient’s prognosis.%目的:分析影响小儿毛细支气管炎哮喘的相关危险因素。方法:对本院在2010年8月-2013年1月收治的110例毛细支气管炎患者的临床资料进行回顾性分析。结果:患儿的肥胖程度、病情轻重、哮喘家族史和特异性体质是发生小儿毛细支气管炎哮喘的重要危险因素,而患儿的年龄、性别、喂养方式并不是发生小儿毛细支气管炎哮喘的重要危险因素。结论:毛细支气管炎合并哮喘危险因素容易发生哮喘,在临床治疗过程中应尽量控制和预防危险因素,可以改善患儿的预后。

  16. Clinical research on treating bronchiolitis in TCM%小儿推拿合中药宣肺定喘汤治疗毛细支气管炎临床研究

    Institute of Scientific and Technical Information of China (English)

    褚付英

    2014-01-01

    目的:观察应用小儿推拿合中药宣肺定喘汤治疗毛细支气管炎的临床疗效,大力推广有效的绿色治疗。方法:观察69例采用小儿推拿合中药宣肺定喘汤的门诊治疗效果。结果:有效率达97.04%。结论:此疗法疗效显著。%Objective: To observe clinical effects of TCM on bronchiolitis. Methods: 69 patients were given massage plus the Xuanfei Dingchuan decoction. Results:The efficiency was 97.04%. Conclusion:The TCM therapy shows good effects on bronchiolitis.

  17. Interleukin-8,RANTES gene polymorphism and respiratory syncytial virus bronchiolitis%白介素8、RANTES基因多态性与呼吸道合胞病毒毛细支气管炎

    Institute of Scientific and Technical Information of China (English)

    田曼; 陈荣华

    2008-01-01

    呼吸道合胞病毒(respiratory syncytial virus,RSV)感染2岁以下几乎所有的儿童,但只有少数发展为比较严重的毛细支气管炎及毛细支气管炎后反复喘息.随着对其遗传学研究的不断深入,通过对RSV毛细支气管炎患儿基因型的分析,发现白介素8、RANTES存在基因多态性,且可能与RSV毛细支气管炎及毛细支气管炎后反复喘息的易感性相关.%Respiratory syncytial virus(RSV)infects nearly all children under two years old,but only minority of them developed serious bronchiolitis and subsequent wheezing.Whether there is a genetic component is not known.The common single nucleotide polymorphisms in the promoter region of interleukin-8(IL-8)and RANTES upstream of the transcription start site affect their mRNA levels and protein expressions.This review includes the new researches about the genetic association between the IL-8,RANTES gene polymorphism and RSV bronchiolitis and post-bronchiolitis wheezing.

  18. Rheumatoid arthritis and cryptogenic organising pneumonitis.

    Science.gov (United States)

    Rees, J H; Woodhead, M A; Sheppard, M N; du Bois, R M

    1991-05-01

    We describe three patients with rheumatoid arthritis who presented with non-specific pulmonary symptoms, a restrictive defect in lung function and bilateral changes on chest radiograph. Lung histology showed characteristic features of cryptogenic organising pneumonitis and treatment with steroids produced significant improvement. The clinical and laboratory features of cryptogenic organising pneumonitis (otherwise known as bronchiolitis obliterans organising pneumonia, 'BOOP') are discussed and compared with those of bronchiolitis obliterans with which the condition should not be confused. Cryptogenic organising pneumonitis should be considered as one of the pulmonary manifestations of rheumatoid arthritis, but lung biopsy is essential to make the diagnosis.

  19. Uso de surfactante exógeno no tratamento da bronquiolite viral grave: relato de caso Exogenous surfactant treatment for severe acute viral bronchiolitis: case report

    Directory of Open Access Journals (Sweden)

    Luciano S. Vitola

    2001-04-01

    Full Text Available OBJETIVO: descrever os possíveis efeitos clínicos e laboratoriais da instilação traqueal de surfactante exógeno a um lactente com bronquiolite viral aguda grave e submetido a ventilação mecânica. RELATO: menina de 2 meses de idade com diagnóstico clínico de bronquiolite viral aguda e submetida a ventilação mecânica, necessitando de altos picos de pressão inspiratória positiva (35 a 45 cmH2O e elevada fração de oxigênio inspirado (FiO2= 0,9, sem resposta clínica favorável ou melhora na gasometria arterial. Optou-se por instilar surfactante exógeno endotraqueal (Exosurf®, Glaxo - 50 mg/kg para permitir utilizar um regime ventilatório menos agressivo. RESULTADOS: quatro horas após a administração do surfactante, foi possível reduzir o pico inspiratório de pressão (PIP de 35 para 30 cmH2O; a FiO2 de 0,9 para 0,6 e aumentar a pressão positiva ao final da expiração (PEEP de 6 para 9 cmH2O. Neste período observou-se uma elevação na relação paO2/FiO2 de 120 para 266. Ao completar 24 horas, a FiO2 pôde ser reduzida até 0,4. DISCUSSÃO: neste relato pretendemos demonstrar que a inativação do surfactante pode ser um fator decisivo na evolução desfavorável de alguns casos graves de bronquiolite. A instilação traqueal de surfactante, nestes casos, além de promover uma rápida resposta clínica, permite que se adotem técnicas ventilatórias menos agressivas.OBJECTIVE: to describe the possible clinical and laboratory effects of exogenous surfactant instillation into the tracheal tube of a child with severe acute bronchiolitis undergoing mechanical ventilation. CASE REPORT: a 2-month-old girl with clinical diagnosis of acute viral bronchiolitis underwent mechanical ventilation. She required high positive inspiratory peak pressure (35 to 45 cmH2O and high inspiratory fraction of oxygen (FiO2 = 0.9, but showed no clinical response or improvement in the arterial blood gas analysis. An exogenous surfactant (Exosurf

  20. 雾化布地奈德治疗毛细支气管炎临床分析%Clinic analysis of treating bronchiolitis by budesonide atomizing inhalation

    Institute of Scientific and Technical Information of China (English)

    吉大章; 王玉屏; 张小燕

    2012-01-01

    [Objective] To analyse the efficacy and possible mechanism of treating children bronchiolitis caused by respiratory syncytial virus (RSV) and post-infection inflammation of the air passage by budesonide atomizing inhalation. [Methods] 120 children diagnosed with RSV bronchiolitis were randomly divided to atomizing group and common group. The number of pant days during the acute and recovery stage,hospitalization days and recurrence cases of these two groups were recorded and compared. The blood serum eosinophilic cationic proteins (ECP) , IL-6, IL-8 and IL-10 during the acute and recovery stage were tested and compared between the two groups,and statistics analysis was carried out. [Results] There was statistics significance (P<0. 05) of the pant days, hospitalization days and recurrence cases compared between these two groups. The values of ECP,IL-6 and IL-8 in the acute stage were higher than those in the recovery stage (P< 0. 05). The value of IL-10 in the acute stage was lower than in the recover stage (P<0. 05). The difference had statistics significance (Pbronchiolitis, and certain effects in preventing post-infection inflammation of air passage.%[目的]探讨吸入布地奈德治疗儿童呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎及感染后气道炎症的效果与可能发生机制. [方法]将确诊RSV毛细支气管炎120名患儿随机分成雾化组和常规组,记录比较急性期和恢复期喘息持续天数、住院天数及喘息再发例数;检测比较急性期与恢复期血清嗜酸粒细胞阳离子蛋白(eosinophil cationic protein,ECP) 、IL-6、IL-8、IL-10结果,进行统计学分析. [结果] 两组比较喘息持续天数、住院天数及喘息再发例数有统计学意义(P均<0.05);ECP、IL-6、IL-8值

  1. 下肢动脉硬化性闭塞症介入治疗的回顾性分析%Interventional Revascularization of the Lower Limbs Arteriosclerosis Obliterans:A Retrospective Study

    Institute of Scientific and Technical Information of China (English)

    吴正阳; 鲁海涛; 朱悦琦; 谭华桥; 赵俊功

    2012-01-01

    目的 回顾性分析下肢动脉硬化性闭塞症(arteriosclerosis obliterans,ASO)介入治疗的临床疗效和通畅率.方法 从2009年10月到2011年7月,32例(39条下肢)下肢ASO患者在上海交通大学附属第六人民医院行介入治疗.回顾性分析32例ASO患者的血管造影图像,根据病变长度和程度分级.对手术成功患者随访,随访期3 ~16个月,平均随访期(8.7±1.9)个月.随访期内每3个月进行一次下肢MRA或CTA检查,并搜集相关临床资料.结果 技术成功率93%,踝肱指数(ankle-brachial index,ABI)从术前的0.47±0.11提高至术后的0.68±0.02,在随访期末20例取得了稳定疗效,总的通畅率为77%,保肢率为97%.结论 介入治疗ASO安全可行,取得了良好的临床效果及通畅率,其长期疗效尚需进一步观察.%Objective To retrospectively evaluated the clinical efficacy of interventional revascularization for lower limbs arteriosclerosis obliterans (ASO). Methods From Oct 2009 to July 2011, 32 patients (39 limbs) with lower limbs ASO performed interventional revascularization in our center. Angiography was retrospectively analyzed, and every lesion categorized and classified according to its length and severity. The mean follow up period was 3 - 162 months, mean 8.7 ± 1.9 months. Lower limb magnetic resonance angiography (MRA) or computed tomography angiography (CTA) was performed every 3 months during follow-up. The clinical data were collected. Results 93% technical success rate was obtained. Ankle-brachial index (ABI) improved from 0. 47 ±0. 11 to 0. 68 ± 0. 02. At the end of follow up, 20 patients maintained a stable outcome, gained a 77% patency rate and 97% limb salvage rate. Conclusion Interventional revascularization is safe and feasible in the treatment of lower limbs ASO. With encouraging clinical outcome and patency rate, further research is warranted to evaluate long-term outcome.

  2. 杂交手术治疗下肢多节段动脉闭塞32例%Hybrid operation for the treatment of multifocal lesions in arteriosclerosis obliterans of the lower extremity

    Institute of Scientific and Technical Information of China (English)

    唐波; 刘冰; 王海洋; 单鹏; 王海君; 李海斌; 王青山; 黄任平; 韩鹏

    2011-01-01

    Objective To evaluate hybrid operation for arteriosclerosis obliterans (ASO) of the lower extremity. Methods Clinical data of 35 ischemic limbs in 32 ASO cases receiving hybrid operation from May, 2007 to August, 2009 were retrospectively analysed. The indications, clinical result,complications, perioperative mortality, vascular patency rate and limb salvage rate was evaluated.Results Thirty-five ischemic limbs in 32 cases underwent hybrid operation. Procedures were successful in 94% cases (33/35). The average postoperative ABI significantly increased from 0.49 ±0. 18 to 1.06 ± 0. 17 ( one day after surgery) or 0. 96 ± 0. 16 ( six months after therapy). One patient suffered limb amputation due to surgical failure, one case was complicated with cerebral infarction and the operation was terminated. No patient died in perioperative period. Twenty-six cases (28 ischemia limbs) were followed-up from 2 month to 28 months, the follow-up rate was 87% (26/30). Vascular patency rate in 6 months after operation was 93% (26/28), and limb salvage rate was 96% (27/28). Two cases suffered from below-knee reocclusion 5 -6 months after therapy, and one of these two cases needed a limb amputation.Conclusion Hybrid operation is the therapy of choice for multifocal lesions in arteriosclerosis obliterans of the lower extremities with a low risk and higher patency in short term.%目的 探讨杂交手术对下肢多节段动脉闭塞性病变的治疗效果.方法 回顾性分析2007年5月至2009年8月接受杂交手术的32例(35条下肢)多节段动脉闭塞性病变的临床资料,探讨杂交手术的适应证、治疗效果、并发症、围手术期死亡率、血管通畅率及保肢率.结果 33条患肢获得手术成功,成功率为94%(33/35).患者术后次日、术后6个月的踝肱指数(ABI)分别为1.06±0.17与0.96±0.16.与术前(0.49±0.18)相比,差异有统计学意义(P<0.05).2例手术失败中1例因术中并发脑梗死,终止手术;1例膝下

  3. Indicación de la fisioterapia respiratoria convencional en la bronquiolitis aguda Indications of conventional chest physiotherapy in acute bronchiolitis

    Directory of Open Access Journals (Sweden)

    Liliana Bohé

    2004-06-01

    Full Text Available Los objetivos de este trabajo fueron evaluar la utilidad de la fisioterapia respiratoria convencional en el tratamiento de la bronquiolitis aguda y determinar su influencia sobre los días de hospitalización. Se realizó un ensayo clínico controlado aleatorizado, donde se incluyeron dieciseis pacientes con bronquiolitis que fueron tratados dos veces al día con fisioterapia torácica y se compararon con dieciséis pacientes control, con la misma patología, quienes recibían sólo aspiración nasofaríngea. El grupo de tratamiento presentó un promedio en el score clínico de dificultad respiratoria al ingreso de 5.56 (± 1.96 y al alta 3.25 (± 1.27. El grupo control presentó un score de 5.75 (± 1.61 y 3.12 (± 1.30, p=0.77 y p=0.76 respectivamente. Respecto al promedio en los días de hospitalización fue de 4.00 (± 2.00 en el grupo de tratamiento y de 3.87 (± 1,30 para el grupo control, p=0.84. Concluimos que la fisioterapia respiratoria no aporta beneficio en su uso rutinario en el manejo de la broquiolitis aguda ni acorta los días de hospitalización.To evaluate the benefits of conventional chest physiotherapy in acute bronchiolitis, 32 patients were allocated in a randomized controlled trial, 16 were given twice daily chest physiotherapy compared with 16 controls who were not given chest physiotherapy. The treatment group showed a mean clinical score for respiratory disability at admission of 5.56 (± 1.96, and 3.25 (± 1.27 when discharged. The control group presented a score of 5.75 (± 1.61 and 3.12 (± 1.30, p=0.77 and p=0.76 respectively. The mean length of illness in hospital in the treatment group was 4.00 (± 2.00 vs 3.87 (± 1.30 in the control group, p=0.84. Chest physiotherapy does not produce clinically important benefits in the treatment of acute bronchiolitis.

  4. Arterialização do arco venoso do pé para tratamento da tromboangeíte obliterante Arterialization of the venous arch of the foot for the treatment of thromboangiitis obliterans

    Directory of Open Access Journals (Sweden)

    Cesar Roberto Busato

    2008-09-01

    Full Text Available Em isquemia crítica sem leito arterial distal, um dos modos de irrigar o membro isquêmico é derivar o fluxo de maneira retrógrada através do sistema venoso. As primeiras tentativas de fístulas arteriovenosas terapêuticas datam do início do século passado. Realizadas na parte proximal dos membros inferiores, não obtiveram resultados favoráveis. A partir da década de 70, com os trabalhos pioneiros de Lengua, as fístulas passaram a ser estendidas até o pé, e os bons resultados apareceram em várias publicações. Os autores relatam a evolução de um caso de tromboangeíte obliterante submetida ao procedimento. Essa é uma cirurgia de indicação precisa, que requer estudo pré-operatório arterial e venoso e observância a detalhes de técnica operatória.In critical ischemia without arterial run-off, it is possible to irrigate the ischemic limb by turning the course of the flow reversely through the venous system. The first experiments with therapeutic arteriovenous fistulas date from the beginning of the last century. They were performed in the proximal area of the lower limbs, but showed unfavorable results. Since the 1970's, with the pioneer studies of Lengua, fistulas started being extended to the foot and several publications have reported good outcomes. The authors report the evolution of a case of thromboangiitis obliterans which was submitted to the procedure. This is an accurate surgical procedure which requires arterial and venous preoperative study and the observance of technical operative details.

  5. 180例毛细支气管炎患儿长期随访及其发展为哮喘的相关因素分析%Research of relative factors between bronchiolitis and asthma by long time follow-up of 180 children bronchiolitis patients

    Institute of Scientific and Technical Information of China (English)

    李仁清

    2013-01-01

    目的 对某院住院治疗的180例毛细支气管炎患儿进行长期随访,对其中可能是发展为哮喘的影响因素进行分析.方法 对该院住院治疗的180例毛细支气管炎患儿临床资料进行回顾性分析,所有患儿均随访5年.对性别、家族史、免疫球蛋白、喂养方式、吸入激素、过敏体质及被动吸烟可能是发展为哮喘的影响因素进行Logistic回归分析.结果 180例患儿中共有35例发展为哮喘,发生率为19.4%.单因素分析结果显示:哮喘患儿与非哮喘患儿在家族史、免疫球蛋白、喂养方式、吸入激素、过敏体质及被动吸烟方面差异有统计学意义(P<0.05);多因素分析结果显示:家族史、过敏体质及被动吸烟是毛细支气管炎患儿发展为哮喘的风险因素.母乳喂养、吸入激素、免疫球蛋白的使用是保护因素.结论 家族史、过敏体质及被动吸烟是毛细支气管炎患儿发展为哮喘的风险因素,临床上给予母乳喂养、吸入激素及免疫球蛋白的治疗可减少哮喘的发生.%OBJECTIVE 180 children bronchiolitis patients with the hospitalization treatment were followed up long time, then the relative factors between bronchiolitis and asthma were analyzed. METHODS The data of 180 children bronchiolitis patients with the hospitalization treatment were retrospectively analyzed. All the children were followed up for five years. Sex, family history , immunoglobulin, feeding patterns, inhaled corticosteroid, allergic constitution and passive smoking were observed. Logistic regression analysis was used to analyze the relationship between the factors and asthma. RESULTS 35 of 180 patients (19.4%) with bronchiolitis converted to asthma. Univariate analysis results showed that there were significant difference of family history, immunoglobulin, feeding patterns, inhaled corticosteroid, allergic constitution and passive smoking between the children with or without asthma (P< 0

  6. Significance of peripheral blood interleukin-12 in capillary bronchiolitis patients%毛细支气管炎患儿外周血白细胞介素-12的意义

    Institute of Scientific and Technical Information of China (English)

    王秀芳; 杨慧彬; 宋丽; 张艳丽; 许春娜

    2014-01-01

    Objective To discuss the role of interleukin (IL)-12 in capillary bronchiolitis disease.Methods Fifty-nine cases of capillary bronchiolitis children under 2 years old were enrolled as the bronchiolitis group Ⅰ(n =28) and bronchiolitis group Ⅱ(n =31),36 cases of children with bronchopneumonia of the same age and 31 cases of children suffered from non-infectious diseases such as hernia and renal calculus of the same age were enrolled as bronchopneumonia control group and normal control group respectively.The peripheral blood IL-12 levels of four groups were detected by enzyme-linked immunosorbent assay.Results The levels of the peripheral blood IL-12 in bronchiolitis group Ⅰ,bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group were (34.72±7.96) pg/ml,(55.30 ±6.72) pg/ml,(56.79±10.36) pg/ml and (61.23 ± 11.51) pg/ml respectively.The level of the peripheral blood IL-12 in bronchiolitis group I was significantly lower than that in bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group respectively (P <0.05),and the level of the peripheral blood IL-12 in bronchiolitis group ⅡⅡ was significantly lower than that in bronchopneumonia control group and normal control group respectively (P < 0.05),but there was no significant difference between bronchopneumonia control group and normal control group (P > 0.05).Conclusion The level of IL-12 is one of the important factors for bronchiolitis disease,the reducing of serum level of IL-12 in children who have a high risk factor of capillary bronchiolitis is more obvious.%目的 探讨白细胞介素(interleukin,IL)-12在毛细支气管炎发病过程中的意义.方法 选取59例2岁以下毛细支气管炎患儿,分为毛支Ⅰ组(n=28)和毛支Ⅱ组(n=31),其中毛支Ⅰ组为具有特应质高危因素的患儿,毛支Ⅱ组为无特应质高危因素的患儿.同期住院的同年龄段支气管肺炎患儿36例和患有疝气、肾结石等

  7. 毛细支气管炎患儿单次潮气肺功能测定的临床意义%Clinical significance of single tidal breathing testing in bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    李睿; 王吉安; 许家增; 杨慧敏

    2014-01-01

    目的:探讨毛细支气管炎患儿测定单次潮气肺功能的临床意义。方法检测和比较住院且<1岁的756例初次喘息毛细支气管炎患儿和115例支气管肺炎患儿的单次潮气肺功能。部分达峰时间比≤第20百分位和≥第80百分位的毛细支气管炎患儿出院1年后电话随访其喘息情况。结果毛细支气管炎患儿与支气管肺炎患儿比较,达峰时间比,达峰容积比,吸气时间,吸呼比,呼出25%、50%潮气容积时的呼气流速的差异有统计学意义(P均<0.05)。达峰时间比≤第20百分位的毛细支气管炎患儿1年内再喘息的比例为37.5%;达峰时间比≥第80百分位的毛细支气管炎患儿1年内再喘息比例为11.3%,两组差异有统计学意义(P<0.05)。结论单次潮气肺功能测定提示,阻塞程度较重的毛细支气管炎患儿再次喘息的可能性较大。%Objective To study clinical signiifcance of single tidal breathing testing in bronchiolitis. Methods Infants with bronchiolitis at ifrst wheezing (bronchiolitis group, n=756), and 115 infants with bronchopneumonia (bronchopneumonia group) hospitalized were enrolled. Tidal breathing parameters were analyzed in two groups. Bronchiolitis group was divided according to percentiles of the fraction of exhaled time at peak tidal expiratory lfow to total expiratory time (TPTEF/TE). The episodes of recurrent wheezing of infants below the 20th or above the 80th percentile of TPTEF/TE were followed up by phone calls within 1 year after discharge from the hospital. Results There were signiifcant differences in TPTEF/TE, VPEF/VE, Ti, Ti/Te, TEF75 and TEF50 between bronchiolitis group and bronchopneumonia group. The recurrent wheezing rate of infants with bronchiolitis below the 20th percentile of TPTEF/TE was signiifcantly higher than that above the 80th percentile of TPTEF/TE (37.5%vs 11.3%). Conclusions There is the greater possibility of recurrent wheezing in the infants with the

  8. Fatores de risco associados à hospitalização por bronquiolite aguda no período pós-neonatal Risk factors associated with hospitalization for bronchiolitis in the post-neonatal period

    Directory of Open Access Journals (Sweden)

    Elaine P Albernaz

    2003-08-01

    Full Text Available OBJETIVO: Investigar a relação entre fatores socioeconômicos, características maternas, aleitamento e hospitalização por bronquiolite no período pós-neonatal. MÉTODOS: Estudo caso-controle, aninhado a estudo de coorte de 5.304 crianças nascidas na cidade de Pelotas, RS. O estudo de coorte constitui-se de quatro subestudos, cada um com métodos e logística específicos. As mães foram entrevistadas por meio de questionário padronizado, em visitas hospitalares e domiciliares. Foram definidos como casos as crianças com idade entre 28 e 364 dias, que haviam sido hospitalizadas por bronquiolite. RESULTADOS: De 5.304 crianças da coorte, 113 (2,1% foram hospitalizadas por bronquiolite. A análise multivariada hierarquizada, realizada pela regressão logística, mostrou os seguintes resultados: renda familiar, assim como idade gestacional, estiveram inversamente relacionadas ao risco de hospitalização por bronquiolite. O aleitamento materno desempenhou um fator protetor; crianças com tempo de aleitamento materno inferior a um mês tiveram risco 7 vezes maior de serem hospitalizadas por bronquiolite aguda nos primeiros três meses de vida. O risco de hospitalização por bronquiolite foi 57% maior naquelas expostas ao fumo materno. CONCLUSÕES: A hospitalização por bronquiolite está inversamente relacionada com renda familiar, idade gestacional e tempo de aleitamento materno, e diretamente relacionada com exposição a fumo materno. Não foi evidenciada associação com paridade ou história materna de asma brônquica.OBJECTIVE: To investigate the relationship between socioeconomic factors, maternal characteristics, breastfeeding, and hospitalization for bronchiolitis in the post-neonatal period. METHODS: A nested case-control study with a cohort of 5,304 children born in the city of Pelotas, Brazil, was conducted. The cohort study consisted of four sub-studies with their own methods and logistics. Mothers were interviewed using a

  9. Detection of serum lactic dehydrogenase of infants with bronchiolitis and its clinical significance.%毛细支气管炎患儿血清乳酸脱氢酶水平的变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    代东伶; 王缨; 何柳芳; 刘晓红

    2012-01-01

    Objective To investigate the level of serum lactic dehydrogenase( LDH )of infants with bronchiolitis and its clinical significance. Methods According to the clinical manifestation, 131 infant cases with bronchiolitis were divided into two groups, severe case group ( group S ) and mild case group ( group M ). Serum lactic dehydrogenase was detected by automatic biochemistry analyzer and compared between bronchiolitis cases and control subjects. Results Compared with control group, the infants with bronchiolitis had higher LDH level ( P <0.05 ). On admission, LDH was 316. 3 ±84.6 IU/L in group M and 567. 8 ±101.5 IU/L in group S( P <0.05 ),and it was 188.6 ±59.5 IU/L and 195. 4 ±63.3 IU/L respectively after one week treatment ( P <0.05 ). Moreover, all cases in group M had remission,but 7 cases in group S did not have remission or even aggravated and accompanied by further elevated LDH. Conclusion The changes of LDH level in infants with bronchiolitis may indicate the severity of clinical symptoms, and it makes a significant contribution to evaluate the prognosis of bronchiolitis.%目的 探讨毛细支气管炎患儿血清乳酸脱氢酶(LDH)水平及其临床意义.方法 将131例毛细支气管炎患儿按临床症状分为重症组和轻症组两组,并与正常对照组进行比较.结果 与正常对照组比较,毛细支气管炎患儿LDH显著升高(P<0.05);入院时,轻症组与重症组LDH分别为316.3±84.6 IU/L、567.8±101.5 IU/L(P<0.05),经过1周治疗后轻症组与重症组LDH分别为188.6±59.5 IU/L、195.4±63.3 IU/L(P<0.05);而且治疗1周后轻症组临床症状均缓解,而重症组有7例患儿临床症状无缓解甚至加重,LDH水平进一步升高.结论 毛细支气管炎患儿血清LDH的改变可以提示临床症状轻重,对预后判断也具有临床意义.

  10. 人股动脉粥样硬化相关蛋白的鉴定及其生物学作用%Proteomics analysis on pathogenesis of human atherosclerosis obliterans in human femoral artery

    Institute of Scientific and Technical Information of China (English)

    赵振; 赵海光; 蒋米尔

    2011-01-01

    Objective We used proteomic profiling in an attempt to differentiate and identify histological proteins that were associated with atherosclerosis obliterans (ASO) of human femoral artery.Methods We comparatively analyzed the proteome of 8 atherosclerotic and 5 normal femoral arteries. The differentially expressed proteins were visualized by two dimensional electrophoresis (2-DE) and sequenced by matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS). The protein identification program was used to search the National Center for Biotechnology Information (NCBI) database and International Protein Index (IPI). Results A total of 53 distinct spots corresponding to 13 different proteins were identified by MALDI-TOF-MS using the NCBI and IPI databases. The function information of these 13 proteins mainly involved the pathogenetic mechanisms such as inflammation, innate immunity, oxidative stress, lipid metabolism, amyloid degeneration and so on. Conclusion ASO is associated with distinct patterns of protein expression in the femoral arteries, and differentially expressed 13 proteins may contribute to the pathogenesis. These findings might provide needed biomarkers for ASO and new insight into its pathophysiology.%目的 应用比较蛋白质组学方法探讨人动脉粥样硬化闭塞症(ASO)差异蛋白质的表达及其在ASO发病机制中的作用.方法 选取ASO股动脉8例及正常股动脉5例,提取组织蛋白质,行双向凝胶电泳分离、质谱分析及数据库查询,获得差异蛋白信息.结果 成功建立ASO和正常股动脉双向电泳图谱,含量相差大于2倍以上的蛋白质53个,27个上调,26个下调,质谱鉴定出13种蛋白质,主要与炎症、免疫、氧化应激、脂质代谢等相关.结论 ASO与正常股动脉蛋白质组明显差异,差异蛋白质可能在ASO中起重要作用.

  11. 甘露聚糖结合凝集素基因多态性与毛细支气管炎的相关性研究%Correlation between the genetic polymorphism of mannose-binding lectin and bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈秋燕; 刘一心

    2012-01-01

    目的 探讨甘露聚糖结合凝集素(MBL)与毛细支气管炎是否具有相关性.方法 用ELISA法定量检测50例病例组与50例对照组MBL的血浆水平(ng/ml),并用聚合酶链反应、DNA序列测定法分析其MBL基因第1外显子第52、54、57位密码子的碱基序列.结果 (1)甘露聚糖结合凝集素GTC等位基因频率约为0.135,未见52和57位密码子的点突变;(2)比较病例组、对照组的GTC等位基因频率、血浆水平差异均无统计学意义.结论 未发现MBL的基因多态性与毛细支气管炎的易感性有相关性.%Objective To study the distribution of the genetic polymorphism of the mannose-binding lectin (MBL) codon-52,54,57, and approach the correlation between MBL and the bronchiolitis. Methods Serum levels of MBL were measured by ELIS A method with human MBL ELISA kit. The genotypes of MBL gene codon-52, 54, 57 were detected by DNA sequences. Results No significant difference had been found in the allele frequency of GTC and MBL serum levels between bronchiolitis group and healthy group. Conclusion The polymorphism of the MBL gene does not associate with bronchiolitis.

  12. Clincial observation on treating bronchiolitis in infants in the integrative medicine%中西医结合治疗婴幼儿毛细支气管炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王宽富

    2012-01-01

      目的:探讨中西医结合治疗婴幼儿毛细支气管炎的疗效.方法:将132例毛细支气管炎婴幼患儿随机分为观察组(72例)和对照组(60例),两组均给与利巴韦林、普米克和可必特等药物治疗,观察组加用麻杏石甘汤治疗.结果:观察组在发热消失时间、喘息缓解时间、肺部啰音消失时间及住院时间均较单纯西药治疗更短(P<0.05),总有效率也更高(P<0.05).结论:麻杏石甘汤治疗婴幼儿毛细支气管炎疗效显著,值得临床推广应用.%  Objective:To explore the clinical effects of the integrative medicine in treating bronchiolitis in infants. Methods:132 cases of bronchiolitis in infants were randomly divided into the observation group (72 cases) and the control group (60 cases), the two groups were given ribavirin, pulmicort and combivent and other medicines for treatment, the observation group added the Maxing Shigan decoction. Results: The fever disappeared time, respite relief time, pulmonary rales disappeared time and hospital stay time in the observation group were shorter than that in the pure modern medicine treatment (P<0.05), also the total efficiency was higher (P<0.05). Conclusion:The Maxing Shigan decoction had a significant effect in treating bronchiolitis in infants, was worth promoting in clinical.

  13. 呼吸道合胞病毒毛细支气管炎患儿IL-17改变的意义%Changes of serum IL-17 level in infants with respiratory syncytial virus bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    王同友; 王红兵

    2012-01-01

    目的 探讨呼吸道合胞病毒(RSV)感染毛细支气管炎患儿IL-17改变的意义.方法 采用ELISA方法检测30例RSV感染毛细支气管炎患儿(RSV毛支组)、30例非RSV感染支气管肺炎患儿(非RSV肺炎组)以及 25例健康对照儿(对照组)血清中IL-17浓度,并进行比较分析.结果 RSV毛支组患儿血清IL-17水平明显高于其他2组(P<0.01);非RSV肺炎组患儿血清IL-17水平高于对照组(P<0.01).结论 小儿呼吸道合胞病毒性毛细支气管炎的发生和发展与IL-17异常表达有关.%Objective To explore the change of interleukin 17 (IL -17) in infants with respiratory syncytial virus bronchiolitis and their clinical significance . Methods Serum IL — 17 of 30 respiratory syncytial virus ( RSV) bronchioli— tis infants, 30 pneumonia infants without RSV infection and 25 health controls were detected by using ELISA method. Results Level of serum IL -17 were obviously higher in RSV bronchiolitis infants than those in pneumonia infants with -out RSV infection and health controls (P <0.01). Level of serum IL — 17 of pneumonia infants without RSV was obvi — ously high compared with normal group (P <0.01). Conclusion IL -17 may play an important role in the pathogene-sis of RSV Bronchiolitis in infant.

  14. 综合护理干预辅助治疗毛细支气管炎的疗效观察%The efficacy of Comprehensive nursing intervention as adjunctie treatment in the Children with Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    戴静

    2013-01-01

    Objective To explore the efficacy of comprehensive nursing intervention as adjunctie treatment in the children with bronchiolitis. Methods 102 cases of children with bronchiolitis were randomly divided into two groups. All patients were given the routing drug therapy, and the experiment group was given additional comprehensive nursing intervention including psychiatric nursing, aerosol inhalation and chest physiotherapy on the base of routing drug treatment. Results The experiment group were significantly more efficient than the control group in the main symptoms,signs and hospitalization days were shorter than the control group (P < 0.01), first cure rate were higher than the routing drug therapy (P < 0.05). Conclusion Appropriate comprehensive nursing intervention is beneficial for the rehabilitation of the children with bronchiolitis.%目的探讨护理干预对毛支气管炎治疗的辅助效果。方法102例患儿随机分为两组,均给予常规治疗,观察组在常规治疗的基础上对加用心理护理、雾化吸入和胸部叩击等综合护理干预措施。结果观察组咳嗽、喘憋、肺部体征消失时间和住院天数均较对照组缩短(P <0.05),提高治愈率。结论综合护理干预措施有利于毛细支气管炎患儿的康复。

  15. 毛细支气管炎患儿血清25-(OH) D3与免疫球蛋白水平的变化%Serum levels of 25-(OH) D3 and immunoglobulin in children with bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    江志贵; 吴洁; 刘玲; 林艳; 杨翠艳

    2012-01-01

    目的 研究毛细支气管炎患儿血清25-(OH) D3与免疫球蛋白水平的变化及临床意义.方法 采用酶联免疫法检测35例毛细支气管炎患儿急性期和恢复期及20例健康儿童血清25-( OH) D3水平,速率散射比浊法测定免疫球蛋白含量.结果 毛细支气管炎患儿急性期血清25-( OH )D3、IgG及IgA水平明显低于健康儿童组,而血清IgE明显高于健康儿童组,差异均有统计学意义(P<0.05).毛细支气管炎患儿恢复期血清25-(OH)D3水平较急性期增高,而IgE水平较急性期降低,差异有统计学意义(P<0.05).与健康儿童组比较,毛细支气管炎患儿恢复期血清25-(OH)D3及IgA水平明显降低,而血清IgE明显增高,差异亦有统计学意义(P<0.05).毛细支气管炎患儿急性期血清25-( OH)D3水平与IgG、IgA呈正相关(分别r=0.36,P<0.05;r =0.63,P<0.01),与IgE呈负相关(r=-0.72,P<0.01).毛细支气管炎患儿恢复期血清25-(OH)D3水平与IgE呈负相关(r=-0.34,P<0.05).结论 毛细支气管炎患儿血清25-(OH) D3水平降低及免疫球蛋白水平失衡,提示25-(OH)D3及免疫球蛋白在其发病中起重要作用.%Objective To study the changes in the serum levels of 25-(OH)D3 and immunoglobulins in children with bronchiolitis, and the clinical significance of these changes. Methods Serum levels of 25-( OH) D3 were measured using ELJSA in 35 children with bronchiolitis in the acute and recovery phases and 20 healthy children. Serum levels of immunoglobulins were determined by rate nephelometry. Results Compared with the healthy children, serum 25-(OH) D3, IgG and IgA levels in children with bronchiolitis in the acute phase were significantly lower and, in contrast, serum IgE levels were significantly higher ( P < 0. 05). Serum 25-( OH) D3 levels increased and serum IgE levels decreased significantly in the recovery phase compared with the acute phase in children with bronchiolitis ( P < 0. 05 ). However, compared with the healthy

  16. D-二聚体定量检测在毛细支气管炎中的应用%Application of quantitative detection of D-dimer in bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    陈学高

    2015-01-01

    Objective To investigate the clinical significance of D-dimer changes in children with bronchiol-itis. Methods 61 children with bronchiolitis were selected and divided into the normal group and the severe group based on their situation, and 11 healthy children were taken as the control group. The levels of D-dimer were detec-ted. Results The level of D-dimer was significantly higher in the study group than in the control group, and it was higher in the severe group than in the normal group (P<0. 01). After the treatment, the level of D-dimer decreased significantly in the severe group (P<0. 01). Conclusion The level of plasma D-dimer can be used to judge the se-verity of bronchiolitis.%目的:探讨毛细支气管炎患儿D-二聚体( D-D)水平变化及临床意义。方法随机选取61例毛细支气管炎住院患儿,根据病情程度分为普通组与重症组,同时选取11例同龄健康婴儿作为正常对照组。检测其血浆D-二聚体水平。结果毛细支气管炎患儿组血浆D-二聚体水平显著高于对照组,重症毛细支气管炎患儿血浆D-二聚体水平显著高于普通患儿组,差异具有统计学意义(P<0.01)。而且重症毛细支气管炎患儿治疗前后血浆D-二聚体水平差异显著,具有统计学意义( P<0.01)。结论血浆D-二聚体水平检测可用于毛细支气管炎病情严重程度的判定。

  17. Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis%呼吸道合胞病毒毛细支气管炎患儿中性粒细胞活化及蛋白酶平衡的研究

    Institute of Scientific and Technical Information of China (English)

    刘金玲; 陈志敏

    2009-01-01

    Objective To better understand the neutrophil activation and protease imbalance in respiratory syncytial virus (RSV) bronchiolitis. Methods Pediatric patients with RSV bronchiolitis were collected,11 with the Lowell scores ≥ 10 (severe group),and 19 with the Lowell scores 0.05).结论 呼吸道合胞病毒毛支气道局部存在大量中性粒细胞聚集活化和蛋白酶系统失衡,并可能在其发病中起重要作用.

  18. Pulmonary retransplantation in the Nordic countries

    DEFF Research Database (Denmark)

    Lindstedt, Sandra; Dellgren, Göran; Iversen, Martin;

    2015-01-01

    years (range, 22 to 64 years) underwent re-LTx from 1992 until June 2013, of which 53 had single re-LTx, 21 had double re-LTx, and 1 patient underwent a heart-lung retransplantation. Primary graft dysfunction (PGD) was the primary indication in 9 cases, bronchiolitis obliterans syndrome (BOS) in 62...

  19. Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells

    DEFF Research Database (Denmark)

    Rolandsson, Sara; Andersson Sjöland, Annika; Brune, Jan C;

    2014-01-01

    . This study therefore aimed to identify and characterise the 'bona fide' MSC in human lungs and to investigate if the MSC numbers correlate with the development of bronchiolitis obliterans syndrome in lung-transplanted patients. METHODS: Primary lung MSC were directly isolated or culture-derived from central...

  20. 闭塞性毛细支气管炎1例

    Institute of Scientific and Technical Information of China (English)

    朴香淑

    2009-01-01

    @@ 1901年德国病理学家Lange首次报道并命名了闭塞性毛细支气管炎(bronchiolitis obliterans,BO)[1].吉林省通化市人民医院收治了1例闭塞性毛细支气管炎.现报道如下:

  1. Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus with unusual manifestations and without detectable autoantibodies

    Directory of Open Access Journals (Sweden)

    Jimena Sanz-Bueno

    2014-01-01

    Full Text Available We describe a patient with paraneoplastic autoimmune multiorgan syndrome (PAMS secondary to a lymphoblastic T- cell lymphoma who presented with a lichenoid dermatitis and vitiligo, later developing bronchiolitis obliterans and autoimmune hepatitis. Notably, he had no detectable autoantibodies. The development of vitiligo and autoimmune hepatic involvement probably indicate a role for cytotoxic T- cell lymphocytes in the pathogenesis of this syndrome.

  2. Banff study of pathologic changes in lung allograft biopsy specimens with donor-specific antibodies

    DEFF Research Database (Denmark)

    Wallace, William Dean; Li, Ning; Andersen, Claus B;

    2016-01-01

    -DSAs, and no antibodies (NABs) present. The significance of each histologic variable was reviewed. RESULTS: We found no statistically significant association with acute cellular rejection, airway inflammation, or bronchiolitis obliterans and the presence or absence of antibodies. However, biopsy specimens with DSAs had...

  3. The value of ventilation scintigraphy after single lung transplantation

    NARCIS (Netherlands)

    Ouwens, JP; van der Bij, W; van der Mark, TW; Piers, DA; Koeter, GH

    2004-01-01

    Background: A decrease in forced expiratory volume in 1 second (FEV1) as a diagnostic criterion for bronchiolitis obliterans syndrome (BOS) after single lung transplantation may be influenced significantly by the presence of the native lung. To quantify and to discriminate between the relative contr

  4. Chronic lung allograft dysfunction after lung transplantation: novel insights into immunological mechanisms

    NARCIS (Netherlands)

    Budding, K.

    2016-01-01

    Lung transplantation (LTx) is the final treatment option for patients suffering from end-stage lung diseases. Survival after LTx is hampered by the development of chronic lung allograft dysfunction which presents itself in an obstructive form as the bronchiolitis obliterans syndrome (BOS). BOS is ha

  5. Primary extranodal non-Hodgkin's lymphoma of the lung presenting with bilateral, patchy infiltrates dramatically improving after corticosteroid therapy.

    Science.gov (United States)

    Boon, E S; Graal, M B; van Noord, J A

    1993-10-01

    A 63-year-old man was admitted to the hospital with fever and bilateral, peripheral infiltrates. Infectious disease and malignancy seemed to be excluded by fiberoptic diagnostic procedures. Subsequently, respiratory insufficiency developed, making open lung biopsy impossible. The diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was strongly considered and treatment with corticosteroids was started; this led to dramatic clinical and radiologic improvement for a short time. Eventually, an open lung biopsy specimen disclosed primary extranodal non-Hodgkin's lymphoma of T-cell origin, immunoblastic, of high-grade malignancy according to the Kiel classification. After the first course of chemotherapy, total respiratory insufficiency developed and the patient died. This case is unique in a patient without AIDS.

  6. Computed tomography findings of postoperative complications in lung transplantation; Achados tomograficos nas complicacoes pos-operatorias do transplante pulmonar

    Energy Technology Data Exchange (ETDEWEB)

    Hochhegger, Bruno; Irion, Klaus Loureiro; Marchiori, Edson; Bello, Rodrigo; Moreira, Jose; Camargo, Jose Jesus [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Postgraduate Program in Respiratory Sciences; Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Postgraduate Program in Radiological Sciences], e-mail: brunorgs@mail.ufsm.br

    2009-03-15

    Due to the increasing number and improved survival of lung transplant recipients, radiologists should be aware of the imaging features of the postoperative complications that can occur in such patients. The early treatment of complications is important for the long-term survival of lung transplant recipients. Frequently, HRCT plays a central role in the investigation of such complications. Early recognition of the signs of complications allows treatment to be initiated earlier, which improves survival. The aim of this pictorial review was to demonstrate the CT scan appearance of pulmonary complications such as reperfusion edema, acute rejection, infection, pulmonary thromboembolism, chronic rejection, bronchiolitis obliterans syndrome, cryptogenic organizing pneumonia, post transplant lymphoproliferative disorder, bronchial dehiscence and bronchial stenosis. (author)

  7. High-resolution computed tomography findings in pulmonary complications after bone marrow transplantation: iconographic essay; Tomografia computadorizada de alta resolucao nas complicacoes pulmonares pos-transplante de medula ossea: ensaio iconografico

    Energy Technology Data Exchange (ETDEWEB)

    Gasparetto, Emerson L.; Ono, Sergio E.; Souza, Carolina A. [Parana Univ., Curitiba, PR (Brazil). Hospital de Clinicas. Servico de Radiologia Medica e Diagnostico por Imagem]. E-mail: gasparetto@hotmail.com; Escuissato, Dante L. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina. Disciplina de Radiologia Medica; Rocha, Gabriela de Melo; Inoue, Cezar; Falavigna, Joao M. [Parana Univ., Curitiba, PR (Brazil). Faculdade de Medicina; Marchiori, Edson [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Universidade Federal, Rio de Janeiro (UFRJ), RJ (Brazil). Curso de Pos-graduacao em Radiologia

    2005-12-01

    Bone marrow transplantation has been the treatment of choice for many hematologic diseases. However, pulmonary complications, which may occur in up to 60% of the patients, are the main cause of treatment failure and may be divided in three phases according to the patient's immunity. In the first phase, up to 30 days after the procedure, there is a predominance of non-infectious complications and fungal pneumonia. Viral infections, mainly by cytomegalovirus, are common in the second phase (up to 100 days after bone marrow transplantation). Finally, in the late phase after bone marrow transplantation, non-infectious complications as bronchiolitis obliterans organizing pneumonia and graft-versus-host disease are most commonly seen. The authors present a pictorial essay of the high-resolution computed tomography findings in patients with pulmonary complications after bone marrow transplantation. (author)

  8. Hazy increased density in diffuse lung disease

    International Nuclear Information System (INIS)

    In order to determine the significance of ground glass density on high-resolution CT scans of patients with idiopathic pulmonary fibrosis and other lung disorders, the authors have reviewed 200 high-resolution CT studies and found 50 cases demonstrating areas of hazy increased lung density. Disease entities most often associated with this finding included DIP, UIP, alveolar proteinosis, sarcoidosis, and bronchiolitis obliterans/ organizing pneumonia. Pathologic examination revealed either cellular or fluid material lining terminal air spaces, often associated with alveolar wall infiltration and an absence of fibrosis. Gallium scans and bronchoalveolar lavage in some cases showed active inflammation Follow-up high-resolution CT studies in 10 patients showed either change or resolution of the hazy densities, confirming the presence of a reversible parenchymal lesion

  9. 音乐疗法在基层医院辅助治疗毛细支气管炎疗效观察%The Clinical Observation of Musicotherapy through Bronchiolitis by Adjuvant Therapy in Primary Hospital

    Institute of Scientific and Technical Information of China (English)

    牛俊岩; 王艳芳; 王爱民; 邸素敏; 张敬华

    2011-01-01

    Objective: To observe music therapy in the adjuvant treatment of primary hospital bronchiolitis.Methods:the treatment group were treated based on the use of music therapy adjuvant therapy.Results:The recovery in vital signs,cough,wheezing and pulmonary symptoms disappeared,length of hospital stay was sinificantly shorter than the control group P<0.01.2 groups were compared the efficiency of P<0.01.Conclusion:Music therapy was effective adjuvant treatment of bronchiolitis.%目的:观察音乐疗法在基层医院辅助治疗毛细支气管炎的疗效.方法:治疗组在常规治疗基础上加用音乐疗法辅助治疗.结果:治疗组在生命体征恢复,咳嗽、喘憋及肺部体征消失,住院时间较对照组明显缩短P<0.05.2组显效率比较P<0.05.结论:音乐疗法辅助治疗毛细支气管炎疗效明显.

  10. Research of relative factors between bronchiolitis and asthma by long time follow-up of 206 children bronchiolitis patients%长期随访206例毛细支气管炎患儿发展为哮喘的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    刘志刚

    2014-01-01

    OBJECTIVE:206 children bronchiolitis patients with the hospitalization treatment were fol owed up long time, then the relative factors between bronchiolitis and asthma were analyzed. METHODS:The data of 206 children bronchiolitis patients with the hospitalization treatment were retrospectively analyzed. Al the children were fol owed up for three years. Sex, family history,childbirth,feeding pat erns,al ergy history,immunoglobulin,intestinal tract probiotics,inhaled corticosteroid,al ergic constitution, repeat respiratory tract infections and passive smoking were observed. Logistic regression analysis was used to analyze the relationship between the factors and asthma. RESULTS:48 of 206 patients (23.3%) with bronchiolitis converted to asthma. Univariate analysis results showed that there were significant difference of family history, immunoglobulin, feeding pat erns, inhaled corticosteroid, al ergic constitution and passive smoking between the chil-dren with or without asthma (P﹤0.05). Logistic regression analysis showed that family history, al ergic constitution , repeat respiratory tract infections and passive smoking were the risk factors for asthma, and breast feeding,inhaled corticosteroid, repeat respiratory tract infections and immunoglobulin were the protective factors. CONCLUSION:Family history, Individual al ergic constitution,respiratory tract infections and passive smoking were the risk factors for asthma. Breast feed-ing,inhaled corticosteroid treatment , intestinal tract probiotics and immunoglobulin wil decrease the occurrence of asthma.%目的:对住院治疗的206例毛细支气管炎患儿进行随访2年,对其中可能是发展为哮喘的影响因素进行分析。方法:对住院治疗的206例毛细支气管炎患儿临床资料进行回顾性分析,所有患儿均随访2年。对性别、家族史、生产史、喂养史、过敏史、丙种球蛋白、益生菌应用史、吸入糖皮质激素及被动吸烟可能是发展为哮

  11. Factors Associated with the Occurrence of Asthma after Bronchiolitis%毛细支气管炎后支气管哮喘发生的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    李志华

    2013-01-01

    Objective:To analyze and study the related factors of bronchial asthma after bronchiolitis.Method:84 cases underwent bronchiolitis treatment as the object of study,statistics,analysis of the clinical data(content statistics,analysis include age,gender,disease,etiology and allergen detection),follow-up,diagnosis for the children’s respiratory tract infection and onset of bronchial asthma of children after leaving hospital,according to whether the occurrence of asthma in children,using Logistic statistical analysis might lead to bronchial asthma factors and these factors and bronchial asthma related degree was analyzed.Result:84 cases of capillary bronchitis patients in five years after discharge,there were 32 cases with bronchial asthma. Disease(asthma)group and non onset group multiple factors in children with asthma,family history,lower respiratory tract recurrent infections, with bronchiolitis children age,illness,there were significant differences(P<0.05). It could be said that these factors affect the incidence of bronchial asthma. And the child’s gender,living environment and other factors and the incidence of bronchial asthma had no obvious correlation.Conclusion:Patients with bronchiolitis severity,family history of asthma,accompanied by severe eczema and other LRTI are the main risk factors of bronchial asthma after bronchiolitis.%  目的:分析和探究毛细支气管炎后发生支气管哮喘的相关因素。方法:选取本院就诊的84例毛细支气管炎患儿为研究对象,对其临床资料进行统计、分析(包括患者的年龄、性别、病情、病原学及过敏原检测等),患儿出院后对患儿的呼吸道感染以及气管哮喘的发作情况进行随访、诊断,根据患儿是否发生支气管哮喘,采用Logistic回归分析方法分析可能引起支气管哮喘的因素以及这些因素与支气管哮喘发病的相关程度。结果:84例毛细支气管炎患儿在出院后5年内,有32例发

  12. Analysis of related factors of bronchial asthma after bronchiolitis%毛细支气管炎后支气管哮喘发生的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    廖先辉

    2015-01-01

    Objective To explore the related factors of bronchial asthma after bronchiolitis.MethodsClinical data of 66 children with bronchiolitis who were admitted to our hospital from January,2007 to January,2008 were analyzed retrospectively and the conditions of respiratory tract infection and bronchial asthma of these children after discharge were analyzed.Factors that may cause bronchial asthma and correlations between these factors and bronchial asthma attacks were analyzed in Logistic regression analysis method according to conditions of bronchial asthma of these children.Children were given 5-year follow-ups after discharge,those with bronchial asthma were allocated as the disease group while those without bronchial asthma were allocated to the normal group. Results Children were given 5-year follow-ups after discharge,among whom 25 were with bronchial asthma and the rate was 37.88%.The family history of asthma,lower respiratory tract infection,age and condition of bronchiolitis,etc.all of children in two groups were found to have significant differences after various factors in two groups were compared.These differences had statistically significance(P<0.05).ConclusionSevere conditions,the family history of asthma, accompanied with lower respiratory tract infection etc.all of children with bronchiolitis were all main factors of bronchial asthma caused by bronchiolitis.%目的:探讨毛细支气管炎后与支气管哮喘发生的相关因素。方法对我院2007年1月~2008年1月期间收治的66例毛细支气管炎患儿的临床资料进行回顾性分析,在患儿出院后对其呼吸道感染与气管哮喘发作情况进行分析,并根据患儿的支气管哮喘发生情况采用Logistic回归分析法对可能引发支气管哮喘的因素及这些因素和支气管哮喘发病之前的相关性进行分析。患儿出院给予5年随访,发生支气管哮喘者归为发病组,而未发病者归为正常组。结果患儿出院给予5

  13. Relationship between respiratory syncytial virus bronchiolitis and bronchial asthma%呼吸道合胞病毒毛细支气管炎与支气管哮喘的相关性研究

    Institute of Scientific and Technical Information of China (English)

    李宾; 吴福玲; 冯学斌; 韩兆东; 李营营; 石涛

    2012-01-01

    Objective To explore the relationship between bronchiolitis caused by respiratory syncytial virus (RSV) and bronchial asthma. Methods The levels of interferon-γ (IFN-7) , interleukin-4 (IL-4) , interleukin-10 (IL-10), transforming growth factor-13 (TGF-|3) and interleukin-17 (IL-17) in 31 infants with RSV bronchiolitis, 25 infants with asthma, 27 infants with non-RSV pneumonia and 24 healthy infants were detected by ELISA. Results IL-10 and TGF-P levels in infants with RSV bronchiolitis and infants with asthma were significantly lower than those in the non-RSV pneumonia group and the normal control group (P 0.05) , and also no significant differences were observed between the common pneumonia group and the normal control group ( P > 0.05) . Conclusions The same changes of the levels of IFN-γ, IL-4, IL-10, TGF-P and IL-17 in infants with RSV bronchiolitis and infants with asthma may be a common pathogenesis of RSV bronchiolitis and asthma.%目的 探讨呼吸道合胞病毒(RSV)毛细支气管炎(毛支)与支气管哮喘两者发病机制的相关性.方法采用ELISA法检测31例RSV毛支患儿、25例支气管哮喘患儿、27例非RSV肺炎患儿和24例健康儿童外周血IFN-γ、IL-4、IL-10、TGF-β、IL-17水平,并进行比较分析.结果 RSV毛支患儿和哮喘患儿的IL-10、TGF-β水平显著低于非RSV肺炎患儿和健康对照儿童,而IL-4、IL-17水平则显著高于非RSV肺炎患儿和健康对照儿童(P均< 0.05).RSV毛支患儿和哮喘患儿的IFN-γ/IL-4、IL-10/IL-17比例显著低于非RSV肺炎患儿和健康对照儿童(P均<0.05),哮喘患儿的TGF-β/IL-17显著低于非RSV肺炎患儿与健康对照儿童(P均<0.05).RSV毛支患儿与哮喘患儿之间、非RSV肺炎患儿与健康对照儿童之间IFN-γ、IL-4、IL-10、TGF-β、IL-17水平及其比值IFN-γ/IL-4、IL-10/IL-17、TGF-β/IL-17的差异均无统计学意义(P均>0.05).结论 RSV毛支患儿与哮喘患儿存在相同的外周血细胞因子IFN-γ、IL-4

  14. Progress of inhaled hypertonic saline and epinephrine in the ictal treatment of patients with bronchiolitis%吸入高渗盐水及肾上腺素对毛细支气管炎患儿发作期治疗的研究进展

    Institute of Scientific and Technical Information of China (English)

    王浩

    2014-01-01

    该文回顾了雾化吸入高渗盐水及肾上腺素在临床上治疗患儿毛细支气管炎的应用.对在不同研究中使用雾化吸入高渗盐水及肾上腺素同其他雾化吸入药物治疗毛细支气管炎的疗效进行比较分析,证实雾化吸入高渗盐水及肾上腺素各自在治疗毛细支气管炎时,疗效显著,提示在小剂量高渗盐水及肾上腺素各自雾化吸入及联合使用对于临床治疗毛细支气管炎患儿起到重要的作用.%This paper reviews the application of nebulized hypertonic saline and adrenaline in the treatment of children with bronchiolitis.The efficacy of hypertonic saline and epinephrine in the treatment of bronchiolitis has been analyzed in different experiments.Confirming hypertonic saline and epinephrine respectively in the treatment of bronchiolitis has a significant effect.Prompted each inhalation and combined use of both play an important role in the treatment of bronchiolitis.

  15. Clinical significance of myeliod-derived suppressor cells in peripheral blood and serum interleukin-10 level detection in children with bronchiolitis%毛细支气管炎患儿外周血髓系抑制细胞及血清白细胞介素-10水平检测的意义

    Institute of Scientific and Technical Information of China (English)

    王秀芳; 雷瑞瑞; 张艳丽; 毕丹; 刘莹; 郭智兰; 韩影

    2013-01-01

    目的 检测毛细支气管炎患儿外周血髓系抑制细胞(MDSCs)占单个核细胞比例(MDSCs百分比)及血清IL-10水平,探讨其临床意义.方法 随机选取在郑州大学第三附属医院儿内科就诊的2岁以下毛细支气管炎患儿51例.其中男27例,女24例.分为特应质组(毛支Ⅰ组)(n=25)和非特应质组(毛支Ⅱ组)(n=26).同期随机选取郑州大学第三附属医院儿内科同年龄组外科疝气、肾结石等非感染性疾病术前患儿45例(无特应质疾病史及特应性疾病家族史)(其中男25例,女20例)作为对照组.抽取3组患儿静脉血4 mL,留取1 mL采用流式细胞术检测MDSCs;余3 mL留取血清标本,置-70℃冰箱保存,采用酶联免疫吸附法检测外周血IL-10水平.结果 1.各组患儿MDSCs百分比:毛支Ⅰ组[(3.17±0.24)%]、毛支Ⅱ组[(1.33±0.25)%]均高于对照组[(0.78±0.25)%](P均<0.01);毛支Ⅰ组MDSCs百分比高于毛支Ⅱ组,差异有统计学意义(P<0.01).2.各组患儿外周血IL-10水平比较:毛支Ⅰ组[(31.88 ±3.91) ng/L]、毛支Ⅱ组[(23.85 ±4.10) ng/L]均高于对照组[(13.63 ±2.83) ng/L](P均<0.01);毛支Ⅰ组外周血IL-10水平高于毛支Ⅱ组,差异有统计学意义(P<0.01).3.相关性分析:毛支Ⅰ组MDSCs百分比的分布趋势和血清IL-10水平呈正相关(r =0.717,P<0.01),毛支Ⅱ组、对照组MDSCs百分比与IL-10无相关性(r=0.262、-0.102,P均>0.05).结论 MDSCs通过上调IL-10水平在毛细支气管炎发展为哮喘的过程中起重要作用.%Objective To explore the clinical significance of detecting serum interleukin-10(IL-10) level and the proportion of myeloid-derived suppressor cells (MDSCs) in peripheral blood mononuclear cells (PBMCs) in children with bronchiolitis.Methods Fifty-one children with bronchiolitis less than 2 years old were randomly enrolled including 27 boys and 24 girls.They were divided into 2 groups:bronchiolitis group Ⅰ,25 children with atopic high risks were

  16. The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study.

    Directory of Open Access Journals (Sweden)

    Monika Jevšnik

    Full Text Available Human coronaviruses (HCoVs are associated with a variety of clinical presentations in children, but their role in disease remains uncertain. The objective of our prospective study was to investigate HCoVs associations with various clinical presentations in hospitalized children up to 6 years of age. Children hospitalized with acute bronchiolitis (AB, acute gastroenteritis (AGE, or febrile seizures (FS, and children admitted for elective surgical procedures (healthy controls were included in the study. In patients with AB, AGE, and FS, a nasopharyngeal (NP swab and blood sample were obtained upon admission and the follow-up visit 14 days later, whereas in children with AGE a stool sample was also acquired upon admission; in healthy controls a NP swab and stool sample were taken upon admission. Amplification of polymerase 1b gene was used to detect HCoVs in the specimens. HCoVs-positive specimens were also examined for the presence of several other viruses. HCoVs were most often detected in children with FS (19/192, 9.9%, 95% CI: 6-15%, followed by children with AGE (19/218, 8.7%, 95% CI: 5.3-13.3% and AB (20/308, 6.5%, 95% CI: 4.0-9.8%. The presence of other viruses was a common finding, most frequent in the group of children with AB (19/20, 95%, 95% CI: 75.1-99.8%, followed by FS (10/19, 52.6%, 95% CI: 28.9-75.6% and AGE (7/19, 36.8%, 95% CI: 16.3-61.6%. In healthy control children HCoVs were detected in 3/156 (1.9%, 95% CI: 0.4-5.5% NP swabs and 1/150 (0.7%, 95% CI: 0.02-3.3% stool samples. It seems that an etiological role of HCoVs is most likely in children with FS, considering that they had a higher proportion of positive HCoVs results than patients with AB and those with AGE, and had the highest viral load; however, the co-detection of other viruses was 52.6%.ClinicalTrials.gov NCT00987519.

  17. 盐酸沙格雷酯治疗下肢动脉硬化闭塞症的疗效观察%Effect of sarpogrelate hydrochloride for patients with atherosclerotic obliterans of legs

    Institute of Scientific and Technical Information of China (English)

    任师颜; 王非; 钱松屹; 樊雪强; 刘鹏

    2012-01-01

    Objecive:To evaluate the effect of sarpogrelate hydrochloride (anplag)for patients with atherosclerotic obliterans (ASO)of legs .Methods; The patients with ASO of legs were divided into sarpogrelate hydrochloride group (n=46)and control group (n =42).The patients in sarpogrelate hydrochloride group received sarpogrelate hydrochloride(100mg,tid)and aspirin(100mg.qd).whereas the patients in control group were administered aspirin (100mg,qd)only.The average therapeutic course was 130 days.Clinical manifestation,Rutherford type and ankle brachial index (ABl)were studied.Results:In comparison with control group,the severity of pain,Rutherford type 0 and 1 were improved with statistic significance(P<0.05,P<0.01).Incidence of patients with claudi-cation decreased from 56.6% before treatment to 28.3% after treatment; claudication distance was prolonged(P< 0.01);ABI were improved(0.74±0.17vs0.86±0.18,P<0.01).Conclusion:Anplag has therapeutic effect for patients with ASO of legs.%目的:研究盐酸沙格雷酯对下肢动脉硬化闭塞症(ASO)患者的疗效.方法:ASO患者分为盐酸沙格雷酯治疗组(n=46)和对照组(n=42).治疗组口服盐酸沙格雷酯、阿司匹林,对照组仅口服阿司匹林.每例患者口服阿司匹林100mg/d,盐酸沙格雷酯100mg,3次/d,服用130d.观察患者的临床表现、Rutherford 分型、踝肱指数(ABI)和药物不良反应.结果:治疗组患者感觉疼痛改善,步行距离增加,Rutherford 分型0级和1级患者的改善具有显著性差异(P<0.05,P<0.01).治疗后间歇性跛行从56.6%降低为28.3%,跛行距离显著延长(116.3±72.3m vs 243.5±175.3m,P<0.01),ABI指数显著改善(0.74±0.17 vs 0.86±0.18,P<0.01).结论:盐酸沙格雷酯对ASO患者有明显的治疗作用.

  18. 干扰素联合布地奈德雾化吸入佐治毛细支气管炎疗效观察%The Clinical Study of Interferon Combined with Budesonide for Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    段莉; 周安海

    2012-01-01

    Objective: To evaluate the clinical efficacy of interferon combined with budesonide for bronchiolitis. Methods: One hundred and four hospitalized children who had been diagnosed bronchiolitis were randomly divided into two groups. Two groups received anti-infectives, cough suppressants, expectorants, and oxygen therapy. The treatment group was treated with interferon and budesonide in addition of the routine therapy. The symptoms and signs were observed before and after the treatment. Results: In the treatment group the total effective rate was 98.0% , while in the control group, it was 84.6% (P<0.05). The symptoms and signs such as coughing, wheezing, shortness of breath, difficulty breathing and lung wheezing, wet rale disappearance time and the average length of hospitalization in the treatment group were better than those in the control group. There was a significant difference (P<0. 05). Conclusions: Interferon combined with budesonide is effective against bronchiolitis in children patients.%目的:观察干扰素联合布地奈德雾化吸入治疗毛细支气管炎的疗效.方法:选取凉山州第一人民医院2010年2月至2012年1月诊断为毛细支气管炎的住院患儿104例,随机分为对照组和治疗组各52例.两组均予抗感染、止咳化痰、吸氧等综合治疗,治疗组在此基础上加用干扰素α-2b和布地奈德雾化吸入治疗,观察两组治疗前后咳嗽、喘憋、肺部哮鸣音等症状体征的变化.结果:治疗组和对照组的总有效率分别为98.0%、84.6%,两组比较差异有统计学意义(P<0.05).治疗组在咳嗽、喘憋、气促、呼吸困难和肺部喘鸣音、湿啰音消失时间、平均住院天数等方面均优于对照组,差异有统计学意义(P<0.05).结论:干扰素联合布地奈德雾化吸入治疗毛细支气管炎具有较好的临床疗效.

  19. Effect of Dingchuan Decoction in the treatment of bronchiolitis.%定喘汤辅助治疗毛细支气管炎38例疗效观察

    Institute of Scientific and Technical Information of China (English)

    吴永前; 谢海燕; 曹利军

    2012-01-01

    目的 观察定喘汤辅助治疗毛细支气管炎的疗效.方法 将71例毛细支气管炎住院患儿随机分为治疗组(38例)和对照组(33例),两组均予综合治疗,治疗组在此基础上加用定喘汤.两组均以5d为一个疗程.临床观察比较两组疗效,症状、体征消失时间和住院时间.结果 治疗组总有效率为92.11%,与对照组的66.67%比较差异有统计学意义(P<0.01),治疗组喘鸣音消失时间短于对照组,平均住院天数少于对照组.结论 定喘汤辅助治疗毛细支气管炎效果好.%Objective To observe the effect of adjuvant therapy of Dingchuan decoction in the treatment of bronchiolitis. Methods Seventy-one children with bronchiolitis were randomly divided into the study group (n=38) and the control group (n=33). Patients in the control group were treated by synthetic treatment, while those in the study group were treated adjuvantly by Dingchuan decoction based on synthetic treatment. The therapeutic efficacy, time of disappearance of symptoms and signs, the average length of hospital stay were compared between the two groups. Results The total effective rate was 92.11% in the study group and 66.67% in the control group, with statistically significant difference (P<0.01). In the study group, time of disappearance of wheezing was shorter than that in the control group, and the average length of hospital stay was less. Conclusion Adjuvant use of Dingchuan decoction is quite effective for the treatment of bronchiolitis.

  20. Xiaoer Magan Granules for Treating Pediatric Bronchiolitis in 41 Cases%小儿麻甘颗粒治疗小儿毛细支气管炎41例

    Institute of Scientific and Technical Information of China (English)

    余强; 袁浩宇

    2016-01-01

    目的:观察小儿麻甘颗粒辅助治疗小儿毛细支气管炎的临床疗效。方法选择毛细支气管炎患儿82例,随机分为治疗组和对照组,各41例。对照组给予常规治疗,治疗组在常规治疗基础上加用小儿麻甘颗粒。结果治疗组的治愈率为90.24%,显著高于对照组的78.05%( P<0.05);治疗组在咳嗽、呼吸困难、肺部罗音的缓解时间等方面均明显优于对照组( P<0.05)。结论小儿麻甘颗粒辅助治疗小儿毛细支气管炎的疗效确切,未见明显不良反应,值得临床推广。%Objective To investigate the clinical efficacy of Xiaoer Magan Granules for treating pediatric bronchiolitis. Methods 82 children patients with pediatric bronchiolitis were selected and randomly divided into the treatment group and the control group. The control group received conventional treatment. On the basis of the control group,the treatment group was added with Xiaoer Magan Granules. Results The cure rate of the treatment group was 90. 24%,which was significantly higher than 78. 05% of the control group ( P < 0. 05);The remission time of the cough,respiratory problems,and the lung rale in the treatment group were significantly shorter than those of the control group( P < 0. 05). Conclusion Xiaoer Magan Granules for treating pediatric bronchiolitis has good ef-fect without obvious adverse reactions,it is worthy of clinical promotion.

  1. α-干扰素雾化吸入治疗毛细支气管炎临床效果研究%Study on the clinical effect of alpha interferon atomization inhalation in the treatment of bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    康清华

    2014-01-01

    Objective:To explore the clinical effect of alpha interferon atomization inhalation in the treatment of bronchiolitis. Methods:56 patients with bronchiolitis were selected from December 2012 to December 2013.Acording to random distribution and the voluntary principle,all patients were divided into A group and B group.Basis on patients of the two groups were treated by comprehensive treatment,28 cases of A group were treated by alpha interferon atomization inhalation adjuvant therapy,28 cases of B patients were treated by intramuscular injection of alpha interferon adjuvant therapy.We compared the treatment effects of two groups.Results:After the treatment,the overall threatment effective rate of A group was 96.43%,it was much higher than 85.41% of B group,and the comparison between the two groups in P<0.05,the difference has statistics significance.Conclusion:Alpha interferon atomization inhalation has better curative effect in the treatment of bronchiolitis disease when it is compared with intramuscular injection.%目的:探究雾化吸入α-干扰素治疗毛细支气管炎的临床效果。方法:收治毛细支气管炎患者56例,按照随机分配与自愿的原则,将其平均分为A组和B组。在两组均进行综合性治疗的基础上,A组采用雾化吸入α-干扰素的方式辅助治疗,B组则采用肌内注射α-干扰素的方式辅助治疗,对比两组的治疗效果。结果:经相应治疗后,A组的治疗总有效率96.43%,远高于B组的85.41%,两组比较P<0.05,差异有统计学意义。结论:相比肌内注射,雾化吸入α-干扰素治疗毛细支气管炎具有更好的治疗疗效。

  2. The clinical observation on the treatment of bronchiolitis with tile ambroxol%氨溴索治疗毛细支气管炎55例临床观察

    Institute of Scientific and Technical Information of China (English)

    李永国; 陈淑芳

    2008-01-01

    Objective To observe the efficacy and safety of the intravenously applied ambroxol in the treat-ment of bronchiolitis. Methods 85 eases of bronchiolitis were randomly divided into two groups. 30 eases of control group were treated with common therapy ,55 cases of treatment group were treated with the ambroxol(7.5mg) each time, Ivgtt bid,in addition to common therapy,and the treatment course was 5 days. The improvement of the cough,pant and sputum for the patients, and the untoward reaction for the drug were observed. Results The total effective ratios were 96.4% in treatment group and 80% in control group. There were significant differences between two groups(X2 = 4.33, P < 0.05). One case vomited slightly in treatment. Conclusion The intravenous application of ambroxol in treatment of bronchiolitis was highly effective and safe.%目的 观察氨溴索静脉滴注治疗毛细支气管炎的疗效及安全性.方法 85例毛细支气管炎患儿随机分为治疗组55例,对照组30例.在常规治疗基础上治疗组加用氨溴索7.5 mg/次,每日2次静滴,连续用药5 d.观察两组疗效和药物不良反应.结果 治疗组总有效率96.4%,对照组总有效率80%,两组比较差异有统计学意义(X2=4.33,P<0.05).药物不良反应1例,表现为轻度呕吐.结论 氨溴索静脉应用治疗毛细支气管炎疗效显著、安全可靠.

  3. Clinical observation of Magnesium sulfate on 46 cases of bronchiolitis%硫酸镁治疗毛细支气管炎46例疗效观察

    Institute of Scientific and Technical Information of China (English)

    林小娜

    2009-01-01

    Objective: To investigate the therapeutic effect and safety of magnesium sulfate on bronchiolitis. Methods: 92 children with bronchiolitis were randomly divided into the treatment group(n=46) and the control group(n=46). Two groups received routine therapy, while the control group was treated with aminophylline, the treatment group was treated with magnesium sulfate. Results: The resolution time of clinical wheezing and hospitalize were obviously shortened in the treatment group compared with the control group (P<0.01).The improving rate of treatment group was significantly higher than that of control group,the figures were 76.1% and 45.7%, P<0.01. The total effectiveness rate of treatment group was higher than that of control group too,the figures were 93.5% and 73.9%, P<0.05. Treatment group had few side reaction occurred. Conclusion: Magnesium sulfate is cheap and have effect in the treatment of bronchiolitis, it has few side reaction and can be widely used in clinic.%目的:探讨硫酸镁治疗毛细支气管炎的临床疗效及安全性.方法:将92例毛细支气管炎患儿随机分为治疗组和对照组各46例,两组均给予常规治疗,在此基础上,治疗组加用硫酸镁,对照组加用氨茶碱静脉滴注.结果:治疗组在喘憋缓解、哮鸣音消失及住院时间方面均明显优于对照组(P<0.01).治疗组的显效率76.1%和总有效率93.5%,均高于对照组,分别为45.7%和73.9%(P<0.01和P<0.05).治疗组未见明显副作用.结论:硫酸镁治疗毛细支气管炎疗效好,价格便宜,不良反应少,值得临床推广应用.

  4. Effects of meglumine adenosine cyclophosphate for treatment of bronchiolitis%环磷腺苷葡胺治疗毛细支气管炎临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    章礼真

    2012-01-01

    目的 探讨环磷腺苷葡胺治疗毛细支气管炎临床疗效与安全性.方法 对我院儿科收住的120例毛细支气管炎患儿随机分为治疗组与对照组.两组均给予常规治疗,治疗组给予环磷腺苷葡胺注射液,每日2~5 mg/kg,静脉滴注,每日1次.观察两组患儿咳嗽、气促、喘息、肺部体征改善时间及住院天数.结果 治疗组有效率(93.3%)明显高于对照组(80%),P<0.05.治疗组咳嗽、气促、喘息、肺部体征改善时间及住院天数较对照组明显缩短,P<0.05.结论 环磷腺苷葡胺治疗毛细支气管炎疗效确切,安全可靠,值得临床推广应用.%Objective To explore the effect of meglumine adenosine cyclophosphate on bronchiolitis. Method 120 infants with bronchiolitis were randomly divided into treatment group and control group. Two groups were given conventional treatment, and the treatment group plus meglumine adenosine cyelophosphate injection, daily 2-5 mg/kg, intravenous drip, 1 time a day. The symptoms such as cough, wheezing and shortness of breath, time of improvement in pulmonary sign and hospital days were observed. Result The effective rate of treatment group ( 93. 3% ) was significantly higher than that in control group (80% ) , and the difference was statistically significant ( x2 -4. 615 ,P < 0. 05 ). The symptoms such as cough, wheezing and shortness of breath, time of improvement in pulmonary sign and hospital days in treatment group was significantly shorter than those in the control group ( P<0. 05 ). Conclusion Meglumine adenosine cyclophosphate had a good effect on bronchiolitis, which is safe, reliable and worthy of clinical application.

  5. 硫酸镁联合细辛脑治疗毛细支气管炎139例临床观察%Magnesium Sulfate Joint Asarone Treatment for 139 Cases with Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    邓志洲

    2013-01-01

      目的:观察硫酸镁联合细辛脑治疗毛细支气管炎的疗效.方法:将139例毛细支气管炎患儿随机分为两组,对照组采用常规治疗加用氨茶碱治疗,治疗组在常规治疗的基础上加用硫酸镁联合细辛脑治疗,全部以7 d为1个疗程,观察疗效.结果:1个疗程后,治疗组总有效率为95.7%,对照组总有效率为78.2%,治疗组疗效明显优于对照组,比较差异有统计学意义(P<0.05).结论:硫酸镁联合细辛脑治疗毛细支气管炎疗效显著,值得临床推广应用.%Objective:To observe curative effect of magnesium sulfate joint asarone treatment for bronchiolitis. Method:The 139 children with bronchiolitis were randomly divided into two groups,the control group received routine treatment plus with aminophylline treatment,the treatment group received the conventional treatment on the basis of add a magnesium sulfate joint asarone treatment with all the 7 d for a period of treatment. To observe the curative effect. Result:After a period of treatment,the total effective rate of the treatment group was 95.7%,and that of the control group was 78.2%. The curative effect of the treatment group was better than that of the control group(P<0.05). Conclusion:The curative effect of magnesium sulfate joint asarone treatment for bronchiolitis is distinct,which is worth clinical application.

  6. 粘附分子CD62P和CD44在毛细支气管炎患儿外周血中的表达及意义%Expression and significance of adhesion molecules CD62P and CD44 in peripheral blood of infants with bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    邹丽萍; 王伟; 张艳丽; 张艳; 王莉

    2015-01-01

    目的:探讨黏附分子CD62P和CD44在毛细支气管炎(简称毛支炎)患儿外周血中的表达及意义。方法选取2014年11月至2015年5月住院治疗的毛支炎发病期患儿33例和恢复期患儿19例为研究对象,同期选取支气管肺炎患儿30例为支气管肺炎组,非感染患儿26例为对照组。采用流式细胞术检测各组患儿外周血CD62P的表达百分比,ELISA法测定血清CD44的水平。结果毛支炎发病期组CD62P和CD44水平显著高于毛支炎恢复期组、支气管肺炎组及对照组(P<0.05);毛支炎恢复期组CD62P和CD44的水平仍高于对照组(P<0.05)。毛支炎发病期患儿外周血中黏附分子CD62P百分比与血清CD44的水平呈正相关(r=0.91, P<0.05)。结论黏附分子CD62P、CD44参与了毛细支气管炎的发病过程,其水平高低可反映毛细支气管炎炎症反应的严重程度。%ObjectiveTo explore the expression and signiifcance of the adhesion molecules CD62P and CD44 in the peripheral blood of infants with bronchiolitis.MethodsThirty-three infants with bronchiolitis in the acute phase and 19 infants with bronchiolitis in the recovery phase, who were hospitalized between November 2014 and May 2015, were enrolled. Thirty infants with bronchopneumonia and 26 infants without infection were enrolled as the bronchopneumonia group and the control group, respectively. The CD62P expression in the peripheral blood of each group was measured by lfow cytometry, and the CD44 level in serum was determined using ELISA.ResultsThe levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the acute phase were signiifcantly higher than those in the bronchiolitis group in the recovery phase, the bronchopneumonia group, and the control group (P<0.05). The levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the recovery phase were also signiifcantly higher than those in the control group (P<0.05). In the

  7. The variations and significance of IL-17 and IgE in infant with respiratory syncytial virus bronchiolitis%呼吸道合胞病毒毛细支气管炎患儿外周血IL-17和IgE水平变化及意义

    Institute of Scientific and Technical Information of China (English)

    陈霞; 曲书强

    2013-01-01

    Objective:Explore the variations of IL-17and IgE after respiratory syncytial virus infection and the relationship between IL-17and serum IgE.In order to provide new molecular basis in which the early prevention of RSV bronchiolitis transform to asthma in children.Method:Using enzyme hnked immunosorbent assay (ELISA) method to determine RSV antibody of children And so is divided into the RSV bronchiolitis group and non-RSV bronchiolitis group.Using enzyme linked immunosorbent assay (ELISA)method to determine IL-17 and serum IgE in 60 cases of children with bronchiolitis and 20 cases of healthy infants in plasma.useing spss to process date.Result:IL-17 in children with RSV bronchiolitis is 17.47 ± 1.30pg/mL,in non-RSV bronchiolitis group is 13.58 ±:0.89pg/mL and in the control group is 10.57 ±0.77 pg/mL.They have significant difference (P <0.05).IL-17 in RSV bronchiolitis group and in non-RSV bronchiolitis group have significant difference (P < 0.05).Serum IgE in children with RSV bronchiolitis is 84.28 ± 15.50IU/mL and in non-RSV bronchiolitis group is73.14 ± 11.70 IU/mL,in the control group is 14.68 ± 1.58IU/mL.They have significant difference (P < 0,05).But serum IgE in RSV bronchiolitis group and in non-RSV bronchiolitis group does not have difference (P >0.05).And IL-17 and IgE in serum in children wtith RSV bronchiolitis correlate.Conclusion:1.IL-17 may participat in the RSV infection immune mechanism.2.Children with bronchiolitis may exist similar immune mechanisms to athma,serum IgE may not be associated with specific pathogens.3.Children with bronchitis after RSV infection IL-17may promote the generation.of serum IgE.%目的 探讨呼吸道合胞病毒感染后血浆IL-17和血清IgE水平变化以及IL-17与IgE的关系,以期为早期预防RSV毛细支气管炎向儿童哮喘转化提供新的分子学依据.方法 利用酶联免疫吸附试验(ELISA)测定60例毛细支气管炎患儿血清RSV抗体,分为RSV毛支组和非RSV毛支组,并

  8. 毛细支气管炎患儿免疫功能的变化及临床意义%The changes of the immune function in infants with bronchiolitis and their clinical implication REN

    Institute of Scientific and Technical Information of China (English)

    任春锋; 杜开先; 刘红春

    2008-01-01

    目的 检测毛细支气管炎(简称"毛支")患儿T细胞亚群和免疫球蛋白、补体等免疫指标,观察其免疫功能的变化以探讨毛细支气管炎的免疫学发病机制.方法 对67例毛支组患儿、40例健康对照采用间接免疫荧光法检测T细胞亚群,定时散射比浊法测定免疫球蛋白、补体.结果 与健康对照组相比,毛支组CD3+(%)与CD8+(%)降低,但无统计学意义,CD4+(%)与CD4+/CD8+增高,差异有统计学意义(P0.05). As compared with those of normal group, the percentage of CD4+ T cells and the ratio of CD4+ to CD8+ were significantly higher (P<0.05 or <0.01) and the levels of serum IgG, C3, C4 were significantly lower in bronchiolitis group(P<0.05 or <0.01). Conclusion Immune function disorder and abnormality occurs in infants with bronchiolitis. T lymphocyte mediated immunity may exert an important antiviral effect. The research from the point of view of cell immunity contributes to evaluation of severity of illness and more effective therapy.

  9. Anisodamine adjective treated Bronchiolitis in children:a clinical analysis of 30 cases%山莨菪碱佐治儿童毛细支气管炎30例临床分析

    Institute of Scientific and Technical Information of China (English)

    姜武林

    2001-01-01

    Objective:To investigate the therapeutic effect of Anisodamine on children's Bronchiolitis.Methods:Children with bronchiolitis were divided into study group and control group by random.The two groups are treated by way of antibiotics,Oxygen and vaporizer,while Anisodanmine is intravenous injected in study group.Results:The total cure rate was 86.6% in study group and 56.6% in control group.There was a signifieant difference (P<0.05) in two groups.Conclusion:The authors tesnt that Anisodamine can assist curing bronchiolitis in children and produce a better clinical effect than conventional therapy.%目的:观察山莨菪碱对儿童毛细支气管炎的治疗作用。方法:儿童毛细支气管炎60例随机分成研究组和对照组,两组均常规抗生素,雾化吸入,吸氧及对症治疗,研究组加山莨菪碱静脉滴注,疗程2~5d。观察治疗后疗效。结果:研究组治愈率86.6%,对照组56.6%。两组有显著差异(P<0.05)。结论:山莨菪碱佐治毛细支气管炎有较好的临床疗效。

  10. The Analysis of Relevant Factors for the Development of Asthma in Children with Bronchiolitis%毛细支气管炎患儿发展为哮喘的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    张怡; 陈培

    2014-01-01

    Objective:To explore the related factors in children with bronchiolitis may develop asthma. Method:For children with bronchiolitis 108 cases were followed up for 3 years. Children with gender,maternal age at birth,father smoking,birth weight,while the incidence of drug and food allergies,family history,immune globulin,feeding patterns, inhaled corticosteroids,allergies,passive smoking,immune globulin,blood routine,trace elements and other indicators were used Logistic regression analysis. Result:Univariate analysis showed that sex,place of residence,father smoking status,age of the mother when the children were born,mode of delivery,birth weight,home decoration or not,the onset of the season,the number of hospital days during bronchiolitis,RSV infection,food allergy drugs history,passive smoking,family history of asthma and allergic rhinitis,atopy,recurrent respiratory tract infections,blood IgE,blood lead,zinc blood,serum iron,eosinophil count and after bronchiolitis into asthma. Multivariate Logistic regression analysis showed:gender(boys),age of the mother when the children were born,passive smoking,the onset of spring,RSV infection positive abnormal birth weight,drug or food allergies,family history of asthma,elevated serum IgE the children with bronchiolitis into a high risk of asthma in children. Conclusion:For children with bronchiolitis risk factors for the development of asthma,early active intervention to reduce morbidity.%目的:探讨毛细支气管炎患儿可能发展为哮喘的相关因素。方法:对108例毛细支气管炎患儿随访3年。对患儿性别、出生时母亲年龄、父亲吸烟、出生体重、发病时情况、药物及食物过敏史、家族史、免疫球蛋白、喂养方式、吸入激素、过敏体质、被动吸烟、免疫球蛋白、血常规、微量元素等指标进行Logistic回归分析。结果:单因素分析结果提示:性别、居住地、父亲吸烟与否、患儿出生时母亲年龄、分娩方

  11. 腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的临床诊治%Clinical treatment of the intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans

    Institute of Scientific and Technical Information of China (English)

    倪东馗; 吴义生; 庞小建; 李立军

    2010-01-01

    Objective To explore the principle of diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans. Method Eighteen cases of patients with intermittent claudication caused by lumbar spine disease combined with lower extremity arteriosclerosis obliterans, using MRI and MRA, to determine the main reason due to of disease, to take the treatment for the cause. Results The patients were followed up for 7 to 24 months, average (16.0 ± 4.7) months. Assessed according to the modified MacNab criteria of clinical efficacy, excellent in 7 cases, good in 8 cases, general in 3 cases,satisfactory rate was 83.3%(15/18). Intermittent claudication were improved with all patients, walking distance of more than 1000 meters, relief rate was 100%. Postoperative ankle brachial score(0.90±0.54 ) was obviously increased compared with preoperative average(0.58±0.36), there was significant statistical difference(P<0.01). All cases were not amputee due to circulation disturbance. Conclusion The diagnosis and treatment of intermittent claudication caused by lumbar spine disease combined lower extremity arteriosclerosis obliterans,it is necessary to collect a history of serious and careful investigation,combined with imaging, can accurately determine the responsibility of lesions, target to give the appropriate treatment, can get a good effect%目的 探讨腰椎疾病同时合并下肢动脉闭塞症所致间歇性跛行的诊治原则.方法 对18例患有腰椎疾病同时合并下肢动脉闭塞症的患者,利用MRI和MRA检查判定所致患者疾病的主要病因,采取针对病因的适宜治疗.结果 本组病例全部获得随访,随访时间7~24(16.0±4.7)个月.按改良MacNab标准评定临床疗效,优7例,良8例,可3例,优良率为83.3%(15/18).全部病例间歇性跛行明显改善,行走距离超过1000m,改善率100%.术后踝肱指数(ABI)0.90±0.54,较术前(0.58±0.36)明显增

  12. Effects of cilostazol on the highsensitive creactive protein, blood lipid and matrix metalloproteinase-9 in elderly patients with lower extremity arteriosclerosis obliterans%西洛他唑对老年下肢动脉硬化闭塞症患者超敏C反应蛋白、血脂及基质金属蛋白酶-9的影响

    Institute of Scientific and Technical Information of China (English)

    刘永升; 魏梅; 刘会英; 岳媛媛; 王乐; 张慧敏

    2012-01-01

    目的 探讨西洛他唑对老年下肢动脉硬化闭塞症患者超敏C反应蛋白(Hs-CRP)、血脂及基质金属蛋白酶9(MMP-9)的影响. 方法 选择老年下肢动脉硬化闭塞症患者60例,随机分为基本治疗组和西洛他唑组,同时以30例健康体检人员作为对照组.观察治疗后各组Hs-CRP、血脂及MMP-9的变化. 结果 治疗后基本治疗组血脂变化不明显,西洛他唑组总胆固醇(TC)水平明显下降,高密度脂蛋白胆固醇(HDL-C)显著上升.治疗后2组Hs-CRP、MMP-9水平均明显下降,西洛他唑组下降幅度大于基本治疗组. 结论 西洛他唑通过降低炎性因子浓度,调解血脂,降低Hs-CRP、MMP-9等途径改善下肢血管病变患者症状.%Objective To observe the effects of Cilostazol on the highsensitive creactive protein ( Hs-CRP) , blood lipid and matrix metalloproteinase-9 ( MMP-9) in elderly patients with lower extremity arteriosclerosis obliterans. Methods Sixty aged patients with lower extremity arteriosclerosis obliterans were randomly assigned to conventional therapy group (group A) and Cilostazol group (group B). Thirty healthy people were selected as the normal group. Hs-CRP, blood lipid and MMP-9 in blood serum were measured be fore and after therapy. Results After therapy the level of blood lipid in blood serum of group A had not a marked change. But the level of high density lipoprotein of group B increased obviously. At the same time the level of Hs-CRP and MMP-9 decreased. The degree of decrease in group B was more significant than that in group A. Conclusions The therapy of Cilostazol can adjust blood lipid metabolism, decrease inflammatory factors and improve symptoms.

  13. Patterns of airway involvement in inflammatory bowel diseases

    Institute of Scientific and Technical Information of China (English)

    Ilias; Papanikolaou; Konstantinos; Kagouridis; Spyros; A; Papiris

    2014-01-01

    Extraintestinal manifestations occur commonly in inflammatory bowel diseases(IBD). Pulmonary manifestations(PM) of IBD may be divided in airway disorders, interstitial lung disorders, serositis, pulmonary vasculitis, necrobiotic nodules, drug-induced lung disease, thromboembolic lung disease and enteropulmonary fistulas. Pulmonary involvement may often be asymptomatic and detected solely on the basis of abnormal screening tests. The common embryonic origin of the intestine and the lungs from the primitive foregut, the co-existence of mucosa associated lymphoid tissue in both organs, autoimmunity, smoking and bacterial translocation from the colon to the lungs may all be involved in the pathogenesis of PM in IBD. PM are mainly detected by pulmonary function tests and highresolution computed tomography. This review will focus on the involvement of the airways in the context of IBD, especially stenoses of the large airways, tracheo-bronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency.

  14. Roles of Th17 cells and IL-17 expression in RSV bronchiolitis%辅助性T细胞17及白介素-17在呼吸道合胞病毒毛细支气管炎的表达及作用

    Institute of Scientific and Technical Information of China (English)

    姚圣连; 徐美玉; 钱金强; 倪永成

    2013-01-01

    目的探讨呼吸道合胞病毒(RSV)毛细支气管炎(毛支)患儿急性期外周血辅助性T细胞17(Th17)和白介素17(IL-17)水平的变化及作用。方法选取RSV毛支急性期患儿(n=28,其中轻度组16例、重度组12例)为毛支组,以哮喘急性发作儿童(n=12)为哮喘组,近期无感染的小儿外科术前患儿(n=10)为对照组。以流式细胞术检测外周血Th17表达,ELISA方法检测外周血IL-17;分析RSV毛支患儿急性期外周血Th17细胞和IL-17表达与病情严重程度的关系。结果毛支重度组外周血Th17细胞比例和IL-17水平分别高于轻度组和对照组,差异均有统计学意义(P<0.05);但与哮喘组比较,差异无统计学意义(P>0.05)。结论 RSV毛细支气管炎患儿急性期外周血Th17细胞和IL-17表达水平增加,Th17细胞和IL-17可能参与RSV毛细支气管炎的发病机制。%Objectives To study the roles of Th17 cells in peripheral blood and the serum level of IL-17 in children with acute respiratory syncytial virus (RSV) bronchiolitis. Methods A total of 28 children with RSV bronchiolitis were selected as bronchiolitis group, among whom twelve cases were assigned into severe group and sixteen cases were assigned into mild group according to the severity of illness. Twelve cases with acute asthma were selected as asthma group. Ten children without recent infection waiting for surgery were chosen as controls. The percentage of Th17 cells in peripheral blood was measured by lfow cytometry. The serum level of IL-17 was detected by ELISA. The association of severity of illness with the percentage of Th17 cells and the level of IL-17 was studied in children with acute RSV bronchiolitis. Results The serum level of IL-17 and the percentage of Th17 cells were signiifcantly higher in the severe bronchiolitis group than those in the control group and mild bronchiolitis group (P0.05). Conclusions The percentage of Th17 cells and serum

  15. Effects of LTE4 and nasopharyngeal secretions ECP on the treatment and prognosis of bronchiolitis%LTE4和鼻咽分泌物ECP对毛细支气管炎治疗和预后的影响

    Institute of Scientific and Technical Information of China (English)

    侯秀玲; 王敬敏; 刘冬梅; 李雪萍

    2015-01-01

    目的:探讨尿白三烯 E4(L T E4)和鼻咽分泌物嗜酸性细胞阳离子蛋白(EC P )对呼吸道合胞病毒(RS V )毛细支气管炎患儿治疗和预后的影响。方法选取2014年1月至2015年3月保定市第二中心医院儿科住院RS V毛细支气管炎患儿79例作为研究对象,设为RS V毛细支气管炎组,均采用常规西医治疗,选取同期涿州市健康小儿75例作为健康对照组,均检测 L T E4和 EC P水平,观察治疗前、后和两组之间以上指标变化情况。结果治疗前,治疗后3、7、14、21 d RSV 毛细支气管炎患儿 LTE4水平分别为(176.35±78.24)、(164.35±71.45)、(112.45±54.62)、(67.55±25.24)、(41.35±10.57)pg/m L ;EC P水平分别为(98.56±61.57)、(88.34±43.64)、(61.46±24.66)、(50.41±17.84)、(34.68±12.54)μg/L ,治疗后明显低于治疗前,治疗前、后比较差异均有统计学意义(P<0.05)。治疗前健康对照组受试者LTE4、ECP水平均明显低于RSV毛细支气管炎患儿,组间比较差异有统计学意义(P<0.05);RSV患儿治疗末 LTE4、ECP水平与健康对照组受试者比较,差异无统计学意义(P>0.05)。结论 LTE4和鼻咽分泌物ECP能反映出RSV毛细支气管炎患儿的治疗进展和预后情况,在临床上有一定指导意义。%Objective To investigate the effects of urinary leukotriene E4 (LTE4) and nasopharyngeal secre‐tions eosinophil cationic protein (ECP) on the treatment and prognosis of children with respiratory syncytial virus (RSV) bronchiolitis .Methods 79 children with RSV bronchiolitis hospitalized in Department of Paediatrics ,Second Central Hospital of Baoding ,Baoding from January 2014 to March 2015 were enrolled as RSV bronchiolitis group , and were treated by conventional therapy .79 healthy children of Zhuozhou City were selected as normal control group .The levels of LTE

  16. 氨溴特罗口服液联合复方异丙托溴铵氧气雾化吸入治疗小儿毛细支气管炎的临床价值%Clinical Value of Ambrocol Oral Liquid Combined With Ipratropium Bromide Oxygen Inhalation in the Treatment of Children With Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    杜燕

    2016-01-01

    Objective Analysis of Ambrocol oral liquid combined with ipratropium bromide oxygen inhalation in the treatment of children with bronchiolitis. Methods 78 cases of bronchiolitis in our hospital were divided into two groups,comparing the clinical effect. Results The total efficiency of the observation group was significantly better than the control group(P<0.05).Conclusion Children with bronchiolitis by ipratropium bromide and ambrocol oral solution for atomizing inhalation treatment can obtain the exact effect.%目的:探析小儿毛细支气管炎采用复方异丙托溴铵与氨溴特罗口服液给予雾化吸入治疗的效果。方法将我院收治的78例毛细支气管炎患儿分成两组,对比分析其临床效果。结果观察组治疗总有效率优于对照组(P<0.05)。结论小儿毛细支气管炎通过复方异丙托溴铵、氨溴特罗口服液联合给予雾化吸入治疗可获得确切的效果。

  17. Subintimal angioplasty true lumen re-entry technology in the treatment of lower limb atherosclerosis obliterans%下肢动脉硬化闭塞症内膜下成形术中再入真腔技术的进展

    Institute of Scientific and Technical Information of China (English)

    周承校; 胡何节

    2012-01-01

    内膜下成形术近年来广泛应用于下肢动脉硬化闭塞症的介入治疗中,再入真腔技术是内膜下成形术的关键.本文综述了超声、同期双向内膜下血管成形术、导管系统等新兴技术在内膜下成形术中再入真腔技术的应用及各类技术的优缺点.%Subintimal angioplasty had been widely used in the intervention of lower extremity arterial obliterans disease in recent years.True lumen re-entry is the key to subintimal angioplasty.This comprehensive exposition of the true lumen re-entry can improve the chances of ultrasound and subintimal arterial flossing with antegraderetrograde intervention and catheter systems and other emerging technologies in the application of subintimal angioplasty,and various types of technology advantages and disadvantages.

  18. 临床路径在呼吸道合胞病毒毛细支气管炎护理中的应用%Application of clinical pathway in the nursing of bronchiolitis caused by respiratory syncytial virus

    Institute of Scientific and Technical Information of China (English)

    赵维笑; 宋文秀

    2016-01-01

    Objective To investigate the application effect and significance of clinical pathway in the nursing of bron-chiolitis caused by respiratory syncytial virus (RSV). Methods Ninety children with bronchiolitis caused by RSV admit-ted to Department of Pediatrics of the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai) from October 2012 to May 2013 were selected as research objects and divided into observation group (n = 60) and control group (n = 30). Both groups received conventional treatment, on basis of which, the control group received general nursing, and the ob-servation group received clinical pathway nursing. The quality of life, length of hospital stay, cost of hospitalization and parents′ health knowledge, nursing satisfaction of the two groups were observed and compared. Results After nursing, the scores of physiological function, physical function, psychological function, body pain, vitality, social function, emo-tional role and total health score of the observation group were significantly higher than those of the control group (P0.05). Conclusion The clinical pathway applied in the nursing of bronchiolitis caused by RSV can improve the quality of life of patients, relieve clinical symptoms, improve children′s satisfaction, the effect is significant.%目的 研究临床路径在呼吸道合胞病毒(RSV)毛细支气管炎护理中的应用效果和意义. 方法 选取2012年10月~2013年5月遵义医学院第五附属(珠海)医院儿科收治的RSV毛细支气管炎患儿90例为研究对象,并将其分为观察组(n=60)和对照组(n=30). 两组行常规治疗后,对照组实施一般性护理,观察组实施临床路径护理,观察比较两组生活质量、住院时间、住院费用、家长健康知识掌握情况及护理满意度. 结果 护理后,观察组患儿生理功能、躯体功能、心理功能、机体疼痛、活力、社会功能、情绪角色及总健康评分均显著高于对照组,差异有统计学意义(P0

  19. Organization within Organization Studies

    DEFF Research Database (Denmark)

    Lopdrup-Hjorth, Thomas

    This paper explores how prevalent contemporary problematizations of organizations coincide with a widespread assessment that Organization Studies (OS) has run out of steam. This impasse, the paper argues, is largely due to the emergence of an organization-phobia that has come to seize several...... strands of theorizing. By attending to the wide-ranging and far-reaching history of this organization-phobia, the paper argues that OS has become increasingly incapable of speaking about its core object. I show how organizations went from being conceptualized as entities of major importance to becoming...... associated with all kinds of ills. Through this history, organizations as distinct entities have been rendered so problematic that they have gradually come to be removed from the center of OS. The costs of this have been rather significant. Besides undermining the grounds that gave OS intellectual...

  20. Clinical Study of Serum IL-13,IL-8,TNF-α,TIgE Level in Children with Bronchiolitis%婴幼儿毛细支气管炎患者血清IL-13、IL-8、TNF-α、TIgE水平的临床研究

    Institute of Scientific and Technical Information of China (English)

    王峻; 李峰; 王丽

    2014-01-01

    目的:探讨婴幼儿毛细支气管炎患者血清白细胞介素13(IL-13)、白细胞介素8(IL-8)、肿瘤坏死因子(TNF-α)、TIgE的水平及临床意义。方法:选取36例急性期毛细支气管炎患儿(其中轻症组20例,重症组16例)、30例普通肺炎患儿以及30例同期健康查体儿,采用酶联免疫吸附法ELISA法检测三组的血清IL-13、IL-8、TNF-α、TIgE水平。结果:两组肺炎患儿血清IL-13、IL-8、TNF-α水平均显著高于正常对照组(P<0.05);毛支炎组血清IL-13、IL-8、TNF-α、TIgE均高于普通肺炎组(P<0.05);毛支炎重症组的TNF-α高于轻症组(P<0.05)。结论:IL-13、IL-8、TNF-α参与毛细支气管炎的发病过程,TNF-α水平与毛支炎病情相关,且毛支炎患儿血清TIgE高于正常对照组。%Objective:To study the clinical significance on serum level of interleukin 13(IL-13),interleukin 8(IL-8),tumor necrosis factor(TNF-α),TIgE in infants with bronchiolitis. Method:36 cases of infantile with bronchiolitis(20 cases of the mild group and 16 cases of the severe group),and 30 cases of ordinary pneumonia,with 30 healthy infants were checked for the IL-13,IL-8,TNF-αand TIgE level with ELISA method.Result:The IL-13,IL-8, TNF-αlevel in the two groups of children with bronchiolitis and ordinary pneumonia were significantly higher than that in the normal control group(P<0.05);the IL-13,IL-8,TNF-α,TIgE level in the bronchiolitis group were higher than the ordinary pneumonia group(P<0.05);the level of TNF-αof the bronchiolitis severe group was higher than that in the mild group(P<0.05). Conclusion:IL-13,IL-8,TNF-αlevels play an important role in the process of bronchiolitis, and TNF-αlevel has association with the course and conditions of the disease;the serum level of TIgE is higher in the bronchiolitis infants than that of other control group.

  1. Knowledge Organization = Information Organization?

    DEFF Research Database (Denmark)

    Hjørland, Birger

    Are the terms ―information organization‖ (IO), ―organization of information‖ (OI) and ―information architecture‖ (IA) synonyms for knowledge organization (KO)? This study uses bibliometric methods, among others, to determine some relations between these terms and their meanings. Apparently the data...

  2. 实验动物呼吸系统主要器官比较组织学研究%Comparative study of the histology of respiratory organs in six laboratory animal species

    Institute of Scientific and Technical Information of China (English)

    戴芳; 王丽; 王涛; 宋蜀伶; 赵玺龙; 徐文漭; 胡奇婵; 李涛; 王媛媛

    2013-01-01

    Objective To obtain histological data of the respiratory organs of laboratory animals and provide standard reference data for pathological inspection, toxicological studies and drug safety evaluation. Methods Thirty ordinary adult rhesus monkeys, 20 KM mice, 20 SD rats, 18 Japanese white rabbits, 16 Beagle dogs, and 20 Tupaia belangeri were included in this study. After intravenous anesthesia, the animals were sacrificed by femoral artery bleeding,and the trachea and lungs were removed, fixed in 10% formalin, and paraffin sections were stained with HE. The histological structure of the trachea and lungs was observed by light microscopy. The similarities and differences of the trachea and lung structures were compared among the different animal species. Results ( 1 ) The goblet cells in the tracheal epithelium; There were more goblet cells in the Beagle dogs and Japanese white rabbits than in the SD rats, KM mice and Tupaia belangeri, and their secretion was mainly neutral mucus in most animal species, but neutral and acidic mucus in Beagle dogs. (2) Distribution of submucosal glandular acini; There were most numerous submucosal glandular acini in the Beagle dogs, less numerous in the rhesus monkeys, SD rats, KM mice, and Tupaia belangeri, and least acini of submucosal mixed glands in the Japanese white rabbits. (3) The bronchial branches; The bronchial tree in the Beagle dogs, rhesus monkeys and Japanese white rabbits was composed of lobar bronchi, segmental bronchi, small bronchi, bronchioles, terminal bronchioles and respiratory bronchioles. In the SD rats, KM mice and Tupaia belangeri, it was composed of only bronchioles, terminal bronchioles and respiratory bronchioles. (4) Histological structure of bronchioles; The bronchioles of Beagle dogs and rhesus monkeys had an intact circular smooth muscle layer, which was a thin circular layer or lack of it in the SD rats, KM mice, Tupaia belangeri and Japanese white rabbits. There was a small amount of goblet cells in

  3. Analysis of correlation factors of the development from bronchiolitis to bronchial asthma%毛细支气管炎发展为支气管哮喘的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    刘雄诚; 李琴丽

    2016-01-01

    目的:探讨毛细支气管炎发展为支气管哮喘(简称“哮喘”)的影响因素。方法对2012年12月至2015年6月,峨眉山市人民医院收治的150例毛细支气管炎,并随访2年的患儿的临床病历资料进行回顾性分析。对性别、饲养宠物、哮喘家族史、肥胖、湿疹史、母乳喂养时间、按时接种卡介苗(BCG)、父亲吸烟情况、过敏体质、疾病严重程度及应用免疫球蛋白(Ig)治疗11项因素影响下毛细支气管炎患儿的哮喘发生率差异进行比较;采用非条件多因素 logistic 回归分析,探讨毛细支气管炎发展为哮喘的影响因素。本研究遵循的程序符合峨眉山市人民医院人体试验委员会制定的伦理学标准,得到该委员会批准,征得受试对象监护人知情同意,并与监护人签署临床研究知情同意书。结果①不同性别及家中是否饲养宠物患儿的哮喘发生率比较,差异无统计学意义(P >0.05);有哮喘家族史、肥胖、有湿疹史、母乳喂养≤4个月、未按时接种 BCG、被动吸烟、过敏体质、重型毛细支气管炎和未应用 Ig 治疗患儿的哮喘发生率(45.2%、41.7%、42.6%、40.8%、37.5%、94.7%、57.9%、48.8%、37.3%)较无哮喘家族史、无肥胖、无湿疹史、母乳喂养>4个月、按时接种 BCG、未被动吸烟、无过敏体质、轻型毛细支气管炎和应用 Ig 治疗患儿(19.4%、21.9%、17.7%、19.8%、22.7%、3.6%、16.1%、18.3%、4.2%)高,且差异均有统计学意义(χ2=7.96、5.37、8.47、5.02、3.84、18.48、10.27、9.65、13.27,P 4个月(OR =0.472,95% CI :1.926~15.687,P 0.05).The incidence rates of asthma in children with family history of asthma,obesity,history of eczema,breast feeding ≤ 4 months,took BCG vaccination not on time, second-hand smoking,allergic constitution,severe type of bronchiolitis,and non-applied Ig treatment (45.2%,41.7%,42.6%,40.8%,37.5%,94.7%,57.9%,48.8%,37.3%)were higher than incidence rates of asthma

  4. The effectiveness of endovascular revascularization for atherosclerosis obliterans in lower extremity:a 2-year experience%下肢动脉硬化闭塞症腔内治疗的疗效分析及2年内的随访观察

    Institute of Scientific and Technical Information of China (English)

    殷晓丽; 畅智慧; 王秋实; 刘兆玉

    2013-01-01

    Objective: To determine the efficacy, safety, and 2—year outcome, including patency and limb salvage, of en-dovascular revascularization in patients with lower extremity atherosclerosis obliterans. Methods: From July 2006 to June 2011, 274 limbs in 222 patients with lower extremity atherosclerosis obliterans were treated by endovascular revascularization. There were 162 males and 60 females, with the mean age of 67.5±11.2 years old. Ninty-two limbs in the aorta-iliac group, 101 limbs in the infrainguinal group, 31 limbs in the infra-popliteal group, and 50 limbs in multiple segment group. The most common presenting symptom was severe intermittent claudication(Rutherford 3, n=116), followed by rest pain (Rutherford 4, n= 87), non -healing ulcer (Rutherford 5, n=37) and gangrene (Rutherford 6, n=34). Patency was evaluated by using ultrasound scanning, CTA or DSA if necessary, and follow-up status was evaluated with the Kaplan-Meier method. Results: Immediate procedural and clinical success were achieved in 269 and 265 limbs respectively. Eighty-six limbs underwent angioplasty, while the rest 183 limbs underwent angioplasty plus stent placement. There were four perioperative death, and two major amputations within the first 30 days. Mean follow-up was 20.8±4.7 months (range, 9-75 months). Two hundred and thirty-five limbs had effective follow-up. Primary patenty rate, secondary patenty and limb salvage rate at 2 years were 71.5%, 75.7%, and 96.2%, respectively. Conclusion: Endovascular revascularization is a feasible, safe, and effective procedure for the treatment of lower extremity atherosclerosis obliterans.%目的:探讨腔内治疗的疗效及2年内的随访结果.方法:回顾性分析我院2006年7月-2011年6月的222例下肢动脉硬化闭塞症患者的资料,共274条患肢.本组病例中男162例,女60例,平均年龄(67.5±11.2)岁.根据不同的病变部位分为:主髂动脉病变92条肢体,股腘动脉101条肢体,膝下动脉31

  5. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher Malcolm; Carlsen, Jørn;

    2010-01-01

    SUMMARY: Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass...... slides, and used these antigen microarrays to profile 48 human serum samples for immunoglobulin G (IgG) and IgM autoantibodies; 27 patients showed no or mild bronchiolitis obliterans syndrome (BOS; a clinical correlate of OB) and 15 patients showed medium to severe BOS. We now report that these BOS...

  6. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    DEFF Research Database (Denmark)

    Hagedorn, Peter; Burton, Christopher M.; Carlsen, Jørn;

    2010-01-01

    Obliterative bronchiolitis (OB) continues to be the major limitation to long-term survival after lung transplantation. The specific aetiology and pathogenesis of OB are not well understood. To explore the role of autoreactivity in OB, we spotted 751 different self molecules onto glass slides......, and used these antigen microarrays to profile 48 human serum samples for immunoglobulin G (IgG) and IgM autoantibodies; 27 patients showed no or mild bronchiolitis obliterans syndrome (BOS; a clinical correlate of OB) and 15 patients showed medium to severe BOS. We now report that these BOS grades could...

  7. Accumulation and significance of MDSCs, IL-10 and IL-12 in the peripheral blood of children with asthma or bronchiolitis%哮喘、毛细支气管炎患儿外周血MDSCs、IL-10和IL-12水平及意义

    Institute of Scientific and Technical Information of China (English)

    张艳丽; 王秀芳; 雷瑞瑞; 栾斌; 刘莹; 宋丽

    2013-01-01

    目的 探讨哮喘、毛细支气管炎(简称毛支)患儿髓系抑制细胞(MDSCs)占外周单个核细胞比例、血清白介素-10(IL-10)及白介素-12( IL-12)的水平及意义.方法 以正常健康儿童及肺炎组为对照,应用流式细胞仪检测哮喘急性发作组、缓解组及毛支Ⅰ组(特应质组)、毛支Ⅱ组(非特应质组)外周血MDSCs占外周单个核细胞的比例(MDSCs%);用ELISA法检测各组儿童血清IL-10、IL-12水平.结果 ①哮喘发作组较哮喘缓解组、肺炎组及正常对照组外周血MDSCs%、血清IL-10升高,IL-12降低(P0.05);④相关性分析:哮喘发作组及毛支Ⅰ组MDSCs占外周血单核细胞的比例和血清IL-10水平存在正相关,与血清IL-12水平呈负相关.结论 MDSCs可能通过上调IL-10、下调IL-12水平在毛细支气管炎发展为哮喘的过程中起重要作用,有望成为毛支筛选为哮喘的指标.%Objective To investigate the accumulation of myeloid-derived suppressor cells (MDSCs), interleukin-10 (IL-10) and interleukin-12 (IL-12) in children with asthma or bronchiolitis and understand their possible significance. Methods We performed flow cytometry to analyze the accumulation of MDSCs in peripheral blood mononuclear cells of children with attack asthma, children with alleviated asthma, bronchiolitis group Ⅰ (atopic group), bronchiolitis group Ⅱ (non-atopic group), as well as children with pneumonia and normal healthy children who served as controls. The accumulation of IL-10 and IL-12 in serum of different groups was analyzed by ELISA. Results ① The accumulation of MDSCs and serum IL-10 in children with attack asthma was significantly higher than that in children with alleviated asthma, children with pneumonia and healthy control group (P0.05). ④Correlation analysis: The accumulation of MDSCs in children with attack asthma and bronchiolitis group Ⅰ was positively correlated with the accumulation of IL-10, but negatively correlated with the

  8. Clinical Observation of Effect of Interferon Atomization Inhalation and Xiyanping Injection on Bronchiolitis%干扰素雾化吸入联合喜炎平注射液治疗小儿急性毛细支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    安红; 高伟; 贾运巧

    2013-01-01

    目的:研究治疗婴幼儿毛细支气管炎的有效疗法.方法:采用重组人干扰素α 2b注射液雾化吸入联合静脉应用喜炎平注射液治疗60例小儿毛细支气管炎,同时与60例对照组患儿进行疗效对比.结果:治疗组患儿的治愈率为93.3%,对照组患儿的治愈率为66.6%(x2=13.3,P<0.05);治疗组临床主要症状好转以及住院时间较对照组明显缩短(P<0.05).结论:干扰素雾化吸入联合喜炎平注射液治疗小儿毛细支气管炎疗效确切,值得推广.%Objective:To study the effective therapy in the treatment of bronchiolitis of infants.Methods:Using recombinant human interferon α 2b injection atomization inhalation combined with intravenous application of treatment of 60 cases of children with bronchiolitis,their therapeutic effects were compared with 60 cases of control group.Results:The treatment group cure rate was 93.3%,the cure rate of the control group was 66.6% (x2=13.3,P<0.05); the main clinical symptoms of the treatment group were improved and the length of hospital stay was significantly shorter than that in the control group (P<0.05).Conclusion:The effect of interferon atomization inhalation combined with Xiyanping injection in the treatment of children with bronchiolitis is exact,and it is worthy of promotion.

  9. 沙丁胺醇、异丙托溴铵联合氟替卡松吸入治疗毛细支气管炎的临床研究%Effect of atomize inhaling ventolin,fluticasone and ipratropine on the treatment of bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    刘明强

    2009-01-01

    目的 探讨沙丁胺醇、异丙托溴铵联合氟替卡松吸入治疗毛细支气管炎的疗效. 方法 将毛细支气管炎患儿 208 例随机分为两组,观察组和对照组各104 例,两组常规治疗方法 相同,观察组给予沙丁胺醇、异丙托溴铵联合氟替卡松吸入,对照组仅予常规治疗.观察两组治疗效果及解除主要症状和体征的时间,进行统计学分析. 结果 观察组治愈率、缓解喘憋及缩短哮鸣音持续时间均明显优于对照组(P<0.05) . 结论 沙丁胺醇、异丙托溴铵联合氟替卡松吸入治疗毛细支气管炎显效迅速,疗效显著.%Objective To investigate the effect of atomize inhaling ventolin,fluticasone and ipratropine on the treatment of bronchiolitis. Methods 208 patients with bronchiolitis were divided into observation group and control group.The observation group was atomizing inhaled ventolin,fluticasone and ipratropine,the control group was given routine treatment. Results The effective rate of observation group was better than that of the control group. The difference between the two groups was significant (P<0.01 or P<0.05). Conclusion The curative effect of atomize inhaling ventolin,fluticasone and ipratropine on the bronchiolitis was faster and better.

  10. Constrictive pericarditis after lung transplantation: an under-recognized complication.

    Science.gov (United States)

    Karolak, Wojtek; Cypel, Marcelo; Chen, Fengshi; Daniel, Lorretta; Chaparro, Cecilia; Keshavjee, Shaf

    2010-05-01

    Primary graft dysfunction, acute rejection, and infection account for most of the early morbidity after lung transplantation, with bronchiolitis obliterans syndrome accounting for most late morbidity. Mediastinal and pericardial complications, in the form of constriction, are not common. We present 4 patients with constrictive pericarditis after lung transplantation and recommend that constrictive pericarditis be considered in the differential diagnosis in lung transplant recipients who present with signs and symptoms of systemic and pulmonary venous congestion. PMID:20207169

  11. Noninvasive Investigations for the Early Detection of Chronic Airways Dysfunction Following Lung Transplantation

    OpenAIRE

    Cook, Richard C.; Guy Fradet; Nestor L Muller; Daniel F Worsley; David Ostrow; Levy, Robert D

    2003-01-01

    BACKGROUND: The diagnosis of chronic rejection after lung transplantation is limited by the lack of a reliable test to detect airways disease early.OBJECTIVES: To determine whether maximum midexpiratory flow (MMEF), or changes on high resolution computed tomography (HRCT) or ventilation/perfusion lung (V/Q) scans are sensitive and specific for early detection of bronchiolitis obliterans syndrome (BOS; forced expiratory volume in 1 s [FEV1] less than 80% post-transplant baseline) by evaluating...

  12. 小儿闭塞性细支气管炎1例报道

    Institute of Scientific and Technical Information of China (English)

    房中华; 王雪峰

    2009-01-01

    闭塞性细支气管炎(bronchiolitis obliterans,BO)是与小气道炎症性损伤相关的慢性气流阻塞综合征,在儿童中是一种相对少见而严重的慢性阻塞性肺病。我院采用中西医结合疗法治愈BO1例,报道如下。

  13. Acute chemical pneumonitis caused by nitric acid inhalation: case report

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Hyung Shim; Lee, In Jae; Ko, Eun Young; Lee, Jae Young; Kim, Hyun Beom; Hwang, Dae Hyun; Lee, Kwan Seop; Lee, Yul; Bae, Sang Hoon [Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2003-06-01

    Chemical pneumonitis induced by nitric acid inhalation is a rare clinical condition. The previously reported radiologic findings of this disease include acute permeability pulmonary edema, delayed bronchiolitis obliterans, and bronchiectasis. In very few published rare radiologic reports has this disease manifested as acute alveolar injury; we report a case of acute chemical pneumonitis induced by nitric acid inhalation which at radiography manifested as bilateral perihilar consolidation and ground-glass attenuation, suggesting acute alveolar injury.

  14. Regional ventilation/perfusion mismatch pattern in patient with Swyer James (MacLeod's) syndrome

    OpenAIRE

    Sait Sager; Sertac Asa; Reşit Akyel; Ersan Atahan; Bedii Kanmaz

    2014-01-01

    Swyer James (McLeod′s) syndrome (SJMS) is an uncommon disease, which occurs as a result of childhood bronchiolitis obliterans. Patients may not be diagnosed until later in their life. A 46-year-old man underwent ventilation/perfusion scintigraphy for acute onset of dyspnea. The scan showed markedly diminished ventilation and perfusion unilaterally on the right middle and inferior lobes. However, mismatched ventilation-perfusion pattern was shown on the upper right lobe, which was consistent w...

  15. Discrepancy between mRNA and Protein Expression of Neutrophil Gelatinase-Associated Lipocalin in Bronchial Epithelium Induced by Sulfur Mustard

    OpenAIRE

    Majid Ebrahimi; Mehryar Habibi Roudkenar; Abbas Ali Imani Fooladi; Raheleh Halabian; Mostafa Ghanei; Hisatake Kondo; Mohammad Reza Nourani

    2010-01-01

    Sulfur mustard (SM) is a potent vesicant that has been employed as a chemical weapon in various conflicts during the 20th century. More recently, mustard was used in the Iraq conflict against Iranian troops and civilians. At the present time there are more than 40.000 people suffering from pulmonary lesions special bronchiolitis obliterans (BOs) due to mustard gas. SM increases the endogenous production of reactive oxygen species (ROS). Neutrophil Gelatinase-associated Lipocalin 2 (Lcn2, NGAL...

  16. 高、低剂量布地奈德混悬液雾化吸入治疗小儿毛细支气管炎的对比研究%Comparison Study on the Efficacy of Bronchiolitis Between Different Dosage of Nebulised Budesonide Suspension for Inhalation

    Institute of Scientific and Technical Information of China (English)

    刘小芸; 刘巧

    2013-01-01

    Objective To evaluate the clinical features of children with bronchiolitis, and compared their treatment response between different dosage of nebulised budesonide suspension for inhalation. Methods From January to December 2011, a total of 157 cases of children with bronchiolitis were recruited. Related clinical data of children diagnosed and administrated were collected and analyzed by soft ware SPSS 19.0. The patients were randomly divided into low dose group(n= 78) and high dose group(n= 79) , they were nebulised budesonide suspension for inhalation 0. 5 mg once and 1. 0 mg once, respectively. Informed consent was obtained from the parents of each participating child. There had no significance difference between two groups among age,gender ratio and classified of bronchiolitis evaluated(P>0. 05). Results At treatment 30 minutes,children with mild bronchiolitis, Beck score, respiratory frequency in high dose group were much lower than those in low dose group(P0.05).结果 高剂量组患儿在接受BUD混悬液雾化治疗30 min与60 min时的Beck临床评分、呼吸频率均较低剂量组降低更显著,差异均有统计学意义(P<0.01);而血氧饱和度则较低剂量组显著升高,差异有统计学意义(P<0.01);高剂量组患儿的平均住院时间及平均住院费用显著低于低剂量组,差异均有统计学意义(P<0.01);两组患儿均无明显不良反应发生.结论 采用1.0 mg/次雾化吸入BUD混悬液治疗小儿毛细支气管炎较采用0.5 mg/次更能显著降低患儿在吸入治疗30 min,60 min时Beck临床评分及呼吸频率,改善患儿血氧饱和度,并缩短患儿的住院时间,降低住院费用.雾化吸入BUD治疗对患儿无明显不良反应.

  17. Clinical Observation of Montelukast Sodium Assistant Treatment for Syncytial Virus Bronchiolitis%孟鲁司特钠辅助治疗合胞病毒毛细支气管炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    陈进庆

    2015-01-01

    OBJECTIVE:To observe therapeutic efficacy and safety of montelukast sodium assistant treatment for respiratory syncytial virus(RSV)bronchiolitis. METHODS:76 RSV bronchiolitis neonatus were included in this study and randomly divided into control group(37 cases)and observation group(39 cases). Control group was treated with regular treatment,oxygen inhala-tion,sedation,abatement of fever,cough suppression,eliminating phlegm,Budesonide suspension,aerosol inhalation of Albuter-ol solution;observation group was additionally given montelukast 4 mg,qd,on the basis of control group. The clinical efficacy, cough,suffocative and wheezing rale disappearance time,length of stay were compared between 2 groups. The serum level of Cys-teinyl leukotrienes (CysLTs) before and after treatment and ADR were also compared between 2 groups. RESULTS:After treat-ment,total clinical efficacy of observation group(94.87%)was significantly higher than that of control group(78.38%),with sta-tistical significance(P<0.05);the time of couth,suffocative,wheezing rale disappearance and length of stay in observation group were significantly shorter than those of control group,with statistical significance (P<0.05);after treatment,the serum level of CysLTs in 2 groups were both significantly lower than before,the observation group was lower than the control group,with statisti-cal significance(P<0.05). No obvious ADR was found in 2 group during treatment. CONCLUSIONS:Montelukast sodium assis-tant treatment for RSV bronchiolitis is effective with less ADR.%目的:观察孟鲁司特钠辅助治疗呼吸道合胞病毒(RSV)毛细支气管炎的疗效及安全性。方法:选取RSV毛细支气管炎患儿76例,按随机数字表法分为对照组(37例)与观察组(39例)。对照组患儿采用吸氧、镇静、退热、止咳祛痰及布地奈德混悬液、沙丁胺醇溶液雾化吸入等常规治疗,观察组患儿在对照组基础上加用孟鲁司特钠4 mg,qd。观察两

  18. 毛细支气管炎患儿血清γ干扰素、白细胞介素-4水平变化及其临床意义%Changes of Interferon -γ and Interleukin -4 Levels in Serum of Children with Bronchiolitis and Their Clinical Significances

    Institute of Scientific and Technical Information of China (English)

    赵小飞; 向志云; 吴显劲

    2011-01-01

    Objective To explore the changes of interferon -γ( IFN -γ) ,interleukin -4(IL-4) and their correlation with the severity of bronchiolitis in children. Methods 1. IFN - γand IL -4 levels in serum were measured by enzyme - linked immunosorbent assay in 20 healthy children( healthy control group) and 54 children with bronchiolitis before treatment, after treatment and after 2 months of follow- up.2. Fifty - four cases of bronchiolitis based on dyspnea criteria were divided into mild group, moderate group and severe group, and the levels of IFN - γ, IL - 4 in the 3 groups were compared. The levels of INF - γ and IL - 4 in 20 healthy children were measured as controls. Results 1. The level of IFN -γ in children with bronchiolitis before treatment was significantly lower than that in healthy control group( P < 0.01 ).The level of IFN - γin children with bronchiolitis in post - treatment group was significantly higher than that in pre - treatment group, but still significantly lower than that in healthy control group( P <0.01 ). The level of IL-4 in children with bronchiolitis in pre -treatment group was significantly higher than that in healthy control group( P < 0.01 ). The level of IL -4 in children with bronchiolitis in post - treatment group was significantly lower than that in pre - treatment group, but still significantly higher than that in healthy control group (P < 0.01 ). The levels of IFN - γ and IL -4 after 2 months of follow - up were close to those in the healthy control group. 2. The level of IFN - γ in mild group was significantly higher than that in moderate group,and in moderate group was significantly higher than that in severe group( Pa <0.01 ). The level of IL - 4 in moderate group was significantly lower than that in severe group( P < 0.01 ). Conclusions Children with bronchiolitis showed decreased IFN -γ level and increased IL -4 level, so IFN -γ/IL- 4 level was imbalanced, and which was correlated with the degree of severity

  19. An Approach to Relativity of the Lower Extremity Atherosclerosis Obliterans Syndrome Differentiation Typing and Endothelial Function%下肢动脉硬化闭塞症辨证分型与血管内皮功能相关性探讨

    Institute of Scientific and Technical Information of China (English)

    李建鹏; 王峥

    2011-01-01

    Objective:To research the relativity of the lower extremity atherosclerosis obliterans (ASO) syndrome differentiation typing and endothelial function.Methods: 161 cases of ASO in various typings based on syndrome differentiation were observed, the endothelial function indexes were detected.SPSS11.5 for windows software was adopted for statistical treatment.Results :ASO patients had severe endothelial dysfunction(ED) ,ET- 1 and TXB2 in blood plasma of Damp -heat pouring down syndrome group were significantly higher than other groups' s( P < 0.01 ), and the same result to Blood stasis syndrome group' s.But NO in blood serum and 6 - Keto - PGF1α in blood plasma of Damp - heat pouring down syndrome group and Blood stasis syndrome group were significantly lower than Yin -cold congealing syndrome group and Spleen- kidney yang deficiency syndrome group's(P < 0.05 )Conclusion: With respect to the severity of ED, Damp - heat pouring down syndrome group is highest, Blood stasis syndrome group take second place, Yin -cold congealing syndrome group and Spleen -kidney yang deficiency syndrome group is lower.%目的:探讨不同证型的下肢动脉硬化闭塞症(ASO)与血管内皮功能的相关性.方法:选择ASO患者共161例,经辨证后检测各证型患者血管内皮功能指标,采用SPSS 11.5软件包对数据进行统计学处理.结果:ASO患者存在较为严重的血管内皮功能障碍(ED),湿热下注证组患者血浆ET-1、TXB2水平高于其它证型组(P<0.01),血脉瘀阻证为其次;而血清NO水平在此两证型中低于阴寒结聚证及脾肾阳虚证(P<0.05).结论:下肢动脉硬化闭塞症(ASO)湿热下注证血管内皮功能障碍(ED)最为严重,其次为血脉瘀阻证,阴寒结聚证及脾肾阳虚证内皮功能障碍相对较轻.

  20. Matching Organs

    Science.gov (United States)

    ... Donor Organs With Transplant Candidates When a deceased organ donor is identified, a transplant coordinator from an organ ... transplant candidate, you are registered on the national organ transplant waiting list. A living donor may also be identified and evaluated for living ...

  1. 硫酸镁联合维生素AD辅治毛细支气管炎%The Clinical Efficacy of Magnesium Sulfate Combined with Vitamin AD in the Treatment of Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    王红宇; 林莉

    2013-01-01

      目的 探索硫酸镁联合维生素AD辅治毛细支气管炎的疗效.方法 将86例毛细支气管炎患儿随机分为治疗组与对照组,其中治疗组44例,对照组42例,两组在综合性治疗同时,治疗组在对照组基础上加用25%硫酸镁静滴3~5d,另加维生素AD滴剂口服1年,比较两组患儿的临床疗效.结果 治疗组总有效率优于对照组(P<0.05),治疗组咳嗽、喘息、肺部体征消失时间均短于对照组(P<0.05),治疗组日后喘息复发率明显低于对照组.结论 硫酸镁联合维生素AD辅治毛支炎疗效好.%Objective To explore the efficacy of magnesium sulfate combined with vitamin AD in the treatment of bronchiolitis. Methods 86 cases children with bronchiolitis were randomly divided into the treatment group (44cases)and the control group(42cases).The two groups in the same treatment. The treatment group compared with the control group were treated with 25% magnesium sulfate infusion for 3-5 days, plus 1-year oral vitamin AD drops, and compare the clinical efficacy of two groups. Results Treatment group, the total efficiency higher than that in control group(P<0.05). Treatment group, coughing, wheezing, pulmonary signs disappear time shorter than the control group (P<0.05). Future respite recurrence rate of the treatment group was significantly lower than the control group.Conclusion Magnesium sulfate combined with Vitamin AD treatment of bronchiolitis have a good effect.

  2. The effects of different hydration strategies before endovascular treatments to the renal function of the arteriosclerosis obliterans patients%下肢动脉硬化闭塞症腔内治疗不同水化方案对患者肾功能的影响

    Institute of Scientific and Technical Information of China (English)

    朱雅亭; 熊江; 郭伟; 刘小平; 尹太; 贾鑫; 马晓辉; 杜昕

    2010-01-01

    Objective To compare the efficacies of different hydration strategies in protecting the renal function of the arteriosclerosis obliterans(ASO) patients undergoing endovascular treatments. Methods 40 patients who underwent endovascular treatments for arteriosclerosis obliterans of lower extremities in the Vascular Surgery Department of PLA Hospital from January 2009 to October 2009 were divided into normal (eerumcreatinine≤110 μmol/L) and abnormal (serum creatine > 110 μmol/L) groups according to their baseline serum concentration of creatinine before treatments. Each group was treated by different hydration strategies 12 h before procedures. Changes of serum creatinine and creatinine clearance were measured 6,24,48 h after procedures to evaluate the changes of renal function and the effects of different hydration strategies. Results No contrast-induced nephopathy (CIN) was observed among the 40 patients. There are significant differences between normal saline hydration group and control group in the changes of serum creatinine and creatinine clearance 24 h and 48 h after exposure to contrast medium for the normal renal function patients ( P < 0. 05 ). For the patients pre-existing renal dysfunction, no significant difference was found between Sodium Bicarbonate + Saline group and Saline group in the changes of Scr and Ccr 6,24,48 h after exposure to contrast medium(P >0. 05). Conclusion Sodium chloride provides a good efficacy for preventing the adverse effect of contrast medium to the renal function of theASO patients. For the patients pre-existing renal dysfunction, Combination hydration with sodium bicarbonate is not more effective than normal saline alone in preventing contrast-induced renal dysfunction.%目的 比较不同水化方案对行腔内治疗的下肢动脉硬化闭塞症(ASO)患者肾功能的保护作用.方法 2009年1-10月解放军总医院血管外科行腔内治疗的40例ASO患者,根据术前基础肌酐水平分

  3. Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs

    Science.gov (United States)

    Dumkova, Jana; Vrlikova, Lucie; Vecera, Zbynek; Putnova, Barbora; Docekal, Bohumil; Mikuska, Pavel; Fictum, Petr; Hampl, Ales; Buchtova, Marcela

    2016-01-01

    The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level. PMID:27271611

  4. Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs

    Directory of Open Access Journals (Sweden)

    Jana Dumkova

    2016-06-01

    Full Text Available The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level.

  5. Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs.

    Science.gov (United States)

    Dumkova, Jana; Vrlikova, Lucie; Vecera, Zbynek; Putnova, Barbora; Docekal, Bohumil; Mikuska, Pavel; Fictum, Petr; Hampl, Ales; Buchtova, Marcela

    2016-01-01

    The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level. PMID:27271611

  6. 呼吸道合胞病毒毛细支气管炎患儿外周血CD4+CD25+调节性T细胞与Th17细胞功能变化及意义%Changes and the clinical significance of CD4+ CD25+ regulatory T cells and Th17 cells in peripheral blood of infants with respiratory syncytial virus bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    李宾; 吴福玲; 冯学斌; 孙大康; 崔晴晴; 赵志旭

    2012-01-01

    AIM: To observe the percentages of CD4 + CD25+ regulatory T cells (Tregs) and Thl7 cells and the levels of IL-10, TGF-p and IL-17 in peripheral blood of infants with respiratory syncytial virus ( RSV) bronchiolitis. The relationship between above cells, cytokines and RSV bronchiolitis was determined. METHODS: Thirty-three infants with RSV bronchiolitis, twenty-eight infants with non-RSV pneumonia and twenty-six healthy infants were enrolled. The percentages of Tregs and Thl7 cells in peripheral blood were detected by flow cytometer (FCM), and the levels of IL-10, TGF-pand IL-17 in plasma were determined by ELISA. RESULTS: The percentage of Tregs and the levels of IL-10 and TGF-pin infants with RSV bronchiolitis were significantly lower than those in infants with non-RSV pneumonia and healthy infants ( P < 0. 05), while the percentage of Thl7 cells and the level of IL-17 in infants with RSV bronchiolitis were significantly higher than those in infants with non-RSV pneumonia and healthy infants ( P < 0. 05). CONCLUSION: The imbalance between Tregs and Thl7 cells in peripheral blood of infants with RSV bronchiolitis may be one of the pathogenesis of RSV bronchiolitis.%目的:探讨呼吸道合胞病毒(RSV)毛细支气管炎患儿外周血CD4+ CD25+调节性T细胞和Th17细胞及其分泌细胞因子IL-10、TGF-β、IL-17水平变化与RSV毛细支气管炎发病的关系.方法:收集2010-09/2011-04在滨州医学院附属医院儿科住院的33例RSV毛细支气管炎患儿、28例做为阳性对照的非RSV感染性肺炎患儿(肺炎组)及26例正常对照组的健康体检儿外周血,采用流式细胞术(FCM)检测外周血CD4+ CD25+调节性T细胞、Th17细胞百分率,酶联免疫吸附(ELISA)法检测血浆IL-10、TGF-β、IL-17的水平.结果:RSV毛细支气管炎患儿外周血CD4+ CD25+调节性T细胞、IL-10、TGF-β水平显著低于肺炎患儿及健康体检儿(P<0.05),而Th17、IL-17水平则显著高于肺炎患儿与健康体检儿(P<0

  7. Expression of 5-Lipoxygenase mRNA and 5-Lipoxygenase-activating Protein mRNA in the Peripheral Blood White Blood Cells in Respiratory Syncytial Virus Bronchiolitis Children%呼吸道合胞病毒毛细支气管炎患儿血白细胞5-脂氧酶及其激活蛋白mRNA水平检测

    Institute of Scientific and Technical Information of China (English)

    黄柳一; 岳智慧; 孙良忠; 王青梅

    2011-01-01

    [目的]观测呼吸道合胞病毒(RSV)毛细支气管炎患儿外周血白细胞5脂氧酶(5-L0)mRNA及5脂氧酶激活蛋白(FLAP)mRNA水平及其与临床严重程度关系。[方法]17例鼻咽分泌物RSV检测阳性的毛细支气管炎患儿为病例组;同期人院的非感染性外科疾病术前患儿10例为对照组,两组年龄分布及性别构成均无显著性差异。采用荧光定量PCR检测两组患儿外周血白细胞5-LO及FLAP mRNA水平,比较两组患儿血白细胞5-LO及FLAP mRNA水平的差异并分析其与临床严重程度的关系。[结果]病例组患儿外周血白细胞5-LO(0.2364±0.0332)和FLAP(0.4106±0.0575)mRNA水平均较对照组(分别为0.0018±0.0013和0.0044±0.0030)明显升高,P值均<0.01。病例组患儿外周血白细胞5-LO和FLAP mRNA水平与临床严重程度评分均呈正相关(r分别为0.745,0.594,P值均<0.05)。[结论]RSV毛细支气管炎患儿外周血白细胞5-LO mRNA及FLAP mRNA水平升高并与临床严重程度呈正相关。%[Objective] To observe 5-lipoxygenase (5-LO) mRNA level and 5-lipoxygenase-Activating protein (FLAP) mRNA level of the peripheral blood white blood cells (WBC) and their correlation to the clinical manifestation in RSV bronchiolitis children. [Methods] Seventeen children suffered from bronchiolitis whose nasopharyngeal secretion positive for RSV-Ag were put into patient group. 10 preoperative patients with matched age, gender proportion and no evidence of infection were chosen as control group. 5-LO mRNA level and FLAP mRNA level in peripheral blood WBC were measured by FQ Reverse Transcription- Polymerase Chain Reaction (RT-PCR) in both groups. Severity of RSV bronchiolitis was assessed of by respiratory disease assess instrument (RDAI) and the correlation between 5-LO/FLAP mRNA levels and the severity of RSV bronchiolitis were analyzed. [Results] The mRNA levels of 5-LO [(0.2364 ± 0.0332) vs (0.0018 ± 0.0013)]and FLAP [(0.4106 ± 0.0575) vs (0.0044

  8. A case of migratory air space infiltration after radiation therapy for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Fujisawa, Tomoyuki; Hatakeyama, Shinobu; Tachibana, Akio; Suzuki, Kazue [Yaizu Municipal Hospital, Shizuoka (Japan); Oka, Teruaki [Kantou Central Hospital, Tokyo (Japan); Suda, Takahumi; Chida, Kingo; Nakamura, Hirotoshi [Hamamatsu Univ., Shizuoka (Japan). School of Medicine

    2002-08-01

    A 54-year-old woman underwent conserving surgery for right breast cancer, and received a cumulative dose of 50 Gy of radiation therapy to the remaining part of the right breast. About five months after the termination of irradiation, cough and low-grade fever developed. The chest radiograph showed an infiltrative shadow in the right lung field. Organizing pneumonia was identified in the transbronchial lung biopsy specimen. After prednisolone was given to the patient the clinical symptoms and infiltrates seen in the radiograph disappeared. In the course of tapering the prednisolone dose, new infiltrative shadows developed in the upper right lung and the left lung. The histologic changes were shown by transbronchial lung biopsy to be organizing pneumonia. The increased dose of prednisolone resulted in the rapid improvement of the clinical symptoms and chest radiograph abnormalities. This case suggests that breast radiation after conserving surgery for breast cancer may cause a pathologic process similar to that of bronchiolitis obliterans organizing pneumonia. (author)

  9. Organic chemistry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-08-15

    This book with sixteen chapter explains organic chemistry on linkage isomerism such as alkane, cycloalkane, alkene, aromatic compounds, stereo selective isomerization, aromatic compounds, stereo selective isomerization, organic compounds, stereo selective isomerization, organic halogen compound, alcohol, ether, aldehyde and ketone, carboxylic acid, dicarboxylic acid, fat and detergent, amino, carbohydrate, amino acid and protein, nucleotide and nucleic acid and spectroscopy, a polymer and medical chemistry. Each chapter has introduction structure and characteristic and using of organic chemistry.

  10. Transnational Organizing

    DEFF Research Database (Denmark)

    Henriksen, Lasse Folke; Seabrooke, Leonard

    2016-01-01

    networks over who controls issues. Transnational issues are commonly organized through professional battles over how issues are treated and what tasks are involved. These professional struggles are often more important than what organization has a formal mandate over an issue. We highlight how ‘issue...... should be treated and governed by organizations. Using network and career sequences methods, we provide a case of transnational organizing through professionals who attempt issue control and network management on transnational environmental sustainability certification. The article questions how...... transnational organizing happens, and how we can best identify attempts at issue control....

  11. The Clinical Efficacy of Inhaled Budesonide Combined with Salbutamol in the Treatment of Bronchiolitis%布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    陈霞

    2011-01-01

    Objective: To study the clinical efficacy of inhaled budesonide combined with salbutamol in the treatment of bronchiolitis. Methods: Eighty cases of bronchiolitis were randomly divided into two groups. Both groups received symptomatic treatment, such as anti-virus, oxygen inhalation, cough stop and sedation. In addition to symptomatic treatment, the treatment group was given budesonide 1 mg and salbutamol 2.5 mg with the oxygen-driven inhalation, 2 times a day and treatment course for 3 to 7 days. Results:Treatment efficiency and the total effective rate in the treatment group were 90.0% and 97.5% respectively, while those were 70.0% and 90.0% in the control group. The efficiency in the treatment group was significantly higher than that in the control group and the difference was significant ( P<0.05 ). Conclusions: Inhaled budesonide combined with salbutamol in the treatment of bronchiolitis is effective and safe.%目的:探讨布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎的临床疗效.方法:80例毛细支气管炎患儿随机分为两组各40例.两组均给予抗病毒、吸氧、止咳、镇静对症治疗,治疗组在此基础上加用布地奈德1 mg和沙丁胺醇2.5 mg氧气驱动雾化吸入,2次/d,疗程为3~7 d.结果:治疗组显效率90.0%,总有效率97.5%;对照组显效率70.0%,总有效率90.0%,治疗组显效率明显高于对照组,两组比较差异有统计学意义(P<0.05).结论:布地奈德联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效显著,安全性好.

  12. The curative effect observation of three drugs combination application for treatment of bronchiolitis in 50 cases%3种药物联合应用治疗毛细支气管炎50例的疗效观察

    Institute of Scientific and Technical Information of China (English)

    舒继红

    2015-01-01

    目的:探讨毛细支气管炎患儿应用孟鲁司特、氯雷他定加布地奈德吸入治疗的疗效。方法:收治毛细支气管炎患儿100例,随机分为联合用药组和对照组各50例,两组均给予常规治疗,联合用药组在常规治疗基础上联用孟鲁司特、氯雷他定加布地奈德吸入,比较两组疗效。结果:在联合用药组,总有效率94%高于对照组的80.0%(P<0.05),临床症状、体征消失时间短于对照组(P<0.05)。结论:孟鲁司特、氯雷他定加布地奈德吸入治疗毛细支气管炎疗效确切,可以明显改善患儿的临床症状及体征。%Objective:To explore the curative effect of child patients with bronchiolitis treated with montelukast,loratadine plus budesonide.Methods:100 patients with bronchiolitis were selected.They were randomly divided into the combined treatment group and the control group with 50 cases in each group.Two groups were given conventional treatment,and the combined treatment group was given montelukast and loratadine plus budesonide inhalation on the basis of routine treatment.We compared the efficacy of two groups.Results:In the combined treatment group,the total efficiency of 94% was higher than 80% in the control group(P<0.05).The clinical symptoms,physical signs disappeared time was shorter than the control group(P<0.05).Conclusion:The curative effect of child patients with bronchiolitis treated with montelukast,loratadine plus budesonide was exact.It can obviously improve the clinical symptoms and signs of patients.

  13. 普米克令舒联合博利康尼氧气雾化吸入治疗毛细支气管炎120例%Pulmicort combined Bricanyl inhalation of oxygen in treatment of bronchiolitis 120 cases

    Institute of Scientific and Technical Information of China (English)

    闫伯强

    2011-01-01

    目的 观察普米克联合博利康尼以氧气作动力雾化吸入治疗毛细支气管炎的疗效.方法 将240例毛细支气管炎患儿随机分为两组,观察组120例在常规治疗的基础上辅以普米克令舒联合博利康尼氧驱雾化吸入;对照组120例仅进行常规治疗.结果 观察组咳喘消失时间、肺部湿啰音消失时间和住院时间均优于对照组(P<0.05),观察组总有效率91.7%,对照组总有效率55%,两组疗效差异有统计学意义(P<0.05).结论 普米克令舒联合博利康尼治疗小儿毛细支气管炎的临床疗效确切,值得临床推广使用.%Objective To observe the effect of Pulmicort combined Bricanyl with oxygen inhalation therapy for bronchiolitis. Methods Totally 240 patients with bronchiolitis were randomly divided into two groups, 120 patients in the observation group on the basis of conventional therapy supplemented by joint Bricanyl Pulmicort inhalation of oxygen flooding; Control group, only routine treatment of 120 cases. Results The study group cough lost time, pulmonary auscultation and hospital stay were betler than that of the control group (P < 0. 05 ) , observation group the total effective rate was 91. 7% , that of the control group the total efficiency 55% , the difference between the two groups efficacy was statistically significant (P < 0. 05 ). Conclusions The combined Pulmicort and Bricanyl clinical treatment of children with bronchiolitis is effective, is worthy of clinical use.

  14. Organic salmon

    DEFF Research Database (Denmark)

    Ankamah Yeboah, Isaac; Nielsen, Max; Nielsen, Rasmus

    The year 2016 is groundbreaking for organic aquaculture producers in EU, as it represents the deadline for implementing a full organic life cycle in the aquaculture production. Such a shift induces production costs for farmers and if it should be profitable, they must receive higher prices....... This study identifies the price premium on organic salmon in the Danish retail sale sector using consumer panel scanner data for households by applying the hedonic price model while permitting unobserved heterogeneity between households. A premium of 20% for organic salmon is found. Since this premium...... is closer to organic labeled agriculture products than to ecolabelled capture fisheries products, it indicates that consumers value organic salmon as an agriculture product more than fisheries product....

  15. Organic electroluminescence

    CERN Document Server

    Kafafi, Zakya H

    2005-01-01

    Organic light-emitting diode(OLED) technology has achieved significant penetration in the commercial market for small, low-voltage and inexpensive displays. Present and future novel technologies based on OLEDs involve rigid and flexible flat panel displays, solid-state lighting, and lasers. Display applications may range from hand-held devices to large flat panel screens that can be rolled up or hung flat on a wall or a ceiling. Organic Electroluminescence gives an overview of the on-going research in the field of organic light-emitting materials and devices, covering the principles of electroluminescence in organic thin films, as well as recent trends, current applications, and future potential uses. The book begins by giving a background of organic electroluminescence in terms of history and basic principles. It offers details on the mechanism(s) of electroluminescence in thin organic films. It presentsin-depth discussions of the parameters that control the external electroluminescence quantum efficien...

  16. Acute exacerbations of fibrotic interstitial lung disease.

    Science.gov (United States)

    Churg, Andrew; Wright, Joanne L; Tazelaar, Henry D

    2011-03-01

    An acute exacerbation is the development of acute lung injury, usually resulting in acute respiratory distress syndrome, in a patient with a pre-existing fibrosing interstitial pneumonia. By definition, acute exacerbations are not caused by infection, heart failure, aspiration or drug reaction. Most patients with acute exacerbations have underlying usual interstitial pneumonia, either idiopathic or in association with a connective tissue disease, but the same process has been reported in patients with fibrotic non-specific interstitial pneumonia, fibrotic hypersensitivity pneumonitis, desquamative interstitial pneumonia and asbestosis. Occasionally an acute exacerbation is the initial manifestation of underlying interstitial lung disease. On biopsy, acute exacerbations appear as diffuse alveolar damage or bronchiolitis obliterans organizing pneumonia (BOOP) superimposed upon the fibrosing interstitial pneumonia. Biopsies may be extremely confusing, because the acute injury pattern can completely obscure the underlying disease; a useful clue is that diffuse alveolar damage and organizing pneumonia should not be associated with old dense fibrosis and peripheral honeycomb change. Consultation with radiology can also be extremely helpful, because the fibrosing disease may be evident on old or concurrent computed tomography scans. The aetiology of acute exacerbations is unknown, and the prognosis is poor; however, some patients survive with high-dose steroid therapy.

  17. Paraneoplastic Pemphigus

    Directory of Open Access Journals (Sweden)

    Bengü Gerçeker Türk

    2015-12-01

    Full Text Available Paraneoplastic pemphigus (PNP is a dermatosis with 90% mortality which frequently develops secondary to lymphoproliferative malignancies. Non-Hodgkin lymphoma and chronic lymphocytic leukemia (CLL are the mostw common accompaniying lymphoproliferative disorders in PNP. PNP can be part of the clinical variant of paraneoplastic autoimmune multiorgan syndrome (PAMS. In this case, internal organs, especially lung and kidney may expose to autoimmune attack and subsequently organ failure may develop. Bronchiolitis obliterans is a main cause of death in patient with PAMS due to acute lung failure. Here we report, a case of paraneoplastic pemphigus in which polymorphic lesions developed following the diagnosis of CLL in a 58-year-old male patient. Polymorphic lesions as well as underlying malignancy as a two major criteria and IgG, C3 deposition in direct immunofluorescence examination and acantholysis as a two minor criteria determined by Camisa and Helm allowed us to make a diagnosis PNP. The main cause of the death in PNP is a sepsis secondarily to immunosuppression. We lost this patient due to sepsis after methylprednisolone and intravenous immunoglobulin therapy.

  18. CT pathologic correlative study of BOOP

    International Nuclear Information System (INIS)

    Though bronchiolitis obliterans organizing pneumonia (BOOP) was proposed as a new infiltrative lung disease in 1985, we think it has two radiologic problems. First, in spite of interstitial pneumonia, about half of chest radiographs of BOOP has been reported to show alveolar opacities. Second, because radiologic features of both some cases of BOOP and of usual interstitial pneumonia (UIP) show reticular shadows on chest radiographs, it is sometimes difficult to differentiate between two diseases. We correlated CT images with open lung biopsy specimens and evaluated CT's ability to differentiate BOOP from UIP. CT findings of all cases of BOOP were : 1) markedly increased dense infiltrates of various sizes which demarcated sharply from normal lung field. Air bronchogram was always present. 2) less dense images were seen which also stood out against the normal lung field. The former corresponded to air space consolidation formed by organized exudates and inflammatory cells within alveolar ducts and alveoli, while the latter indicated luminal and mural alveolitis. Both findings were sharply delineated from each other probably because of intervening interlobular septa. Conglomerated small cystic shadows and air bronchiolograms within areas of intense lung density were seen in CT images of most of 28 patients with UIP. Those findings proved to correspond to macroscopic or microscopic honey combing which were not seen in our cases of BOOP. These radiologic and pathologic features of UIP were different from those of BOOP. (author)

  19. Diagnosing and treating respiratory syncytial virus bronchiolitis.

    Science.gov (United States)

    Napierkowski, Daria B

    2016-09-22

    Respiratory syncytial virus (RSV) is one of the major causes of respiratory tract illness in children and can lead to significant infection and death. This article discusses the incidence, clinical presentation, diagnosis, current treatment, and prevention options to successfully diagnose and treat infections caused by RSV. PMID:27552683

  20. Atorvastatin calcium plus calcium dobesilate in arteriosclerosis obliterans in lower extremity of diabetes mellitus%阿托伐他汀钙联合羟苯磺酸钙治疗糖尿病下肢动脉硬化闭塞症对照研究

    Institute of Scientific and Technical Information of China (English)

    王学芳

    2015-01-01

    目的:探讨阿托伐他汀钙联合羟苯磺酸钙治疗糖尿病下肢动脉硬化闭塞症的临床疗效。方法将30例2型糖尿病下肢动脉硬化闭塞症患者随机分为治疗组18例和对照组12例,两组均予以诺和灵30 R皮下注射治疗,治疗组在此基础上口服阿托伐他汀钙、羟苯磺酸钙治疗,观察16周。检测两组腓总神经感觉传导速度、踝臂指数、趾臂指数及血糖、血脂的变化。结果治疗后两组腓总神经感觉传导速度、踝臂指数、趾臂指数均较治疗前显著提高(P<0.05或0.01),治疗组较对照组提高更显著(P<0.01);治疗组脉博波传导速度较治疗前显著下降(P<0.01),对照组则无显著变化(P>0.05)。治疗组总胆固醇、三酰甘油、低密度脂蛋白水平均较治疗前显著下降(P<0.01),对照组虽较治疗前有所下降,但差异无显著性(P>0.05)。结论阿托伐他汀钙联合羟苯磺酸钙治疗能有效改善糖尿病下肢动脉硬化闭塞症患者下肢缺血状况。%Objective To explore the efficacy of atorvastatin calcium plus calcium dobesilate in arterioscle‐rosis obliterans in lower extremity (AOLE) of diabetes mellitus (DM ) .Methods Thirty type 2 DM pa‐tients with AOLE were randomly assigned to treatment (n=18) and control group (n=12) ,both groups were treated with isophane protamine biosynthetic human insulin injection (pre‐mixed30R) ,on this basis treatment group took orally atorvastatin calcium plus calcium dobesilate foe 16 weeks .Changes of common peroneal nerve sensory conduction velocity (SCV) ,ankle‐brachial index (ABI) ,toe brachial index (TBI) , blood glucose and blood fat were detected .Results After treatment SCV ,ABI and TBI of both groups heightened more significantly compared with pretreatment (P0 .05) .Cholesterol total ,triacylglycerol and low density lipoprotein level lowered more significantly in treatment (P0 .05) .Conclusion

  1. Organic optoelectronics

    CERN Document Server

    Hu, Wenping; Gong, Xiong; Zhan, Xiaowei; Fu, Hongbing; Bjornholm, Thomas

    2012-01-01

    Written by internationally recognized experts in the field with academic as well as industrial experience, this book concisely yet systematically covers all aspects of the topic.The monograph focuses on the optoelectronic behavior of organic solids and their application in new optoelectronic devices. It covers organic electroluminescent materials and devices, organic photonics, materials and devices, as well as organic solids in photo absorption and energy conversion. Much emphasis is laid on the preparation of functional materials and the fabrication of devices, from materials synthesis a

  2. 温肺化瘀定喘用于小儿风寒闭肺证病毒性毛细支气管炎的临床疗效及安全性分析%Clinical Efficacy and Safety of Lung Warming, Stasis Transforming and Panting Stabilizing for Wind-cold Blocking Lung-type Viral Bronchiolitis in Children

    Institute of Scientific and Technical Information of China (English)

    史永辉

    2015-01-01

    Objective To explore the efficacy and safety of the method of lung warming, stasis transforming and panting stabilizing in treating wind-cold blocking lung-type viral bronchiolitis in Children. Methods 42 children with viral bronchiolitis admitted to our hospital during April 2013 and April 2014 were selected as the observation group in which the method of lung warming, stasis transforming and panting stabilizing was used, and 42 other children with the same disease admitted to our hospital during the same period were selected as the control group in which the inhalation therapy was used. The clinical efficacy and safety of the two groups were compared. Results The therapeutic effect of the two groups were 92.9% and 90.5%,P>0.05; the time of fever, cough, wheeze extinction of the observation group were shorter than those of the control group, P0.05);观察组发热、咳嗽、憋喘消退时间均短于对照组(P>0.05);观察组复发率为2.6%,明显低于对照组的15.8%(P>0.05);均未发生严重药物不良反应。结论该疗法治疗小儿风寒闭肺证病毒性毛细支气管炎的临床疗效确切,可短期内改善临床症状,且用药安全性较高。

  3. Organic Synthesis

    OpenAIRE

    Romea, Pedro

    2014-01-01

    Organic Synthesis is a one-semester course of the fourth year of the Chemistry Degree at the Universitat de Barcelona. This course covers the most important transformations in Organic Chemistry, including a short introduction to the Retrosynthetic Analysis. The aim is to provide a solid knowledge of the main reactions and their mechanism, which could later be improved during Master studies.

  4. Organ Transplantation

    Science.gov (United States)

    ... recipients to reduce the risk of transplant rejection. Rejection happens when your immune system attacks the new organ. If you have a transplant, you must take drugs the rest of your life to help keep your body from rejecting the new organ.

  5. Organic spintronics

    NARCIS (Netherlands)

    Naber, W.J.M.; Faez, S.; Wiel, van der W.G.

    2007-01-01

    We review the emerging field of organic spintronics, where organic materials are applied as a medium to transport and control spin-polarized signals. The contacts for injecting and detecting spins are formed by ferromagnetic metals, oxides, or inorganic semiconductors. First, the basic concepts of s

  6. Organ Facts

    Science.gov (United States)

    ... in certain types of transplants. Discover data and statistics for each center. Visit the OPTN's Organ DataSource now > I am looking for >> About organ allocation About UNOS Being a living donor Calculator - CPRA Calculator - KDPI Calculator - LAS Calculator - MELD ...

  7. Organ Transplantation

    Science.gov (United States)

    ... must be just and fair. Value judgments and economic considerations affect who is admitted to waiting lists and who gets available organs, calling into question the justice and fairness of the allocation system. It is essential to increase the supply of donated organs; one ...

  8. Organic aerosols

    International Nuclear Information System (INIS)

    Organic aerosols scatter solar radiation. They may also either enhance or decrease concentrations of cloud condensation nuclei. This paper summarizes observed concentrations of aerosols in remote continental and marine locations and provides estimates for the sources of organic aerosol matter. The anthropogenic sources of organic aerosols may be as large as the anthropogenic sources of sulfate aerosols, implying a similar magnitude of direct forcing of climate. The source estimates are highly uncertain and subject to revision in the future. A slow secondary source of organic aerosols of unknown origin may contribute to the observed oceanic concentrations. The role of organic aerosols acting as cloud condensation nuclei (CCN) is described and it is concluded that they may either enhance or decrease the ability of anthropogenic sulfate aerosols to act as CCN

  9. 特应质对呼吸道合胞病毒毛细支气管炎患儿鼻咽吸出物IL-4和IL-12及干扰素-γ水平的影响%Effect of Atopy on the IL-4,IL-12 and IFN-γ Levels in NPS of Respiratory Syncytial Virus Bronchiolitis in Infancy

    Institute of Scientific and Technical Information of China (English)

    姚欢银; 王伟; 王小仙; 刘淑梅; 陈啸洪

    2011-01-01

    Objective To study the effect of Atopy on the changes of IL - 4, IL - 12 and IFN - γ levels in NPS of respiratory syncytial virus bronchiolitis in infancy. Methods 49 infants with Bronchiolitis admitted from November 2008 to February 2009 were involved, with 30 cases in RSV positive group, 19 cases in RSV negative group and 23 cases in control group. The RSV positive group was further divided into atopy positive group (18 cases ) and atopy negative group (12 cases ) according to clinical features. The levels of IL-4, IL-12 and IFN-γ in NPS of each group were detected by ELISA technique. Results The level of IL -4 was significantly higher in group of RSV Bronchiolitis at acute stage [ ( 7. 0 ±4. 2 ) ng/L ] than RSV - negative Bronchiolitis group [ ( 4. 9 ± 2. 1 ) ng/L ] and control group [ ( 3. 7 ± 2. 1 ) ng/L ]; However, the level of IFN-γ in the group of RSV Bronchiolitis at acute stage [ ( 135. 3 ± 80. 7 ) ng/L ] was significantly lower than the RSV - Bronchiolitis group [ ( 277. 9 ± 100. 8 ) ng/L ] and control group [ ( 252. 7 ± 80. 2 ) ng/L ] ( P < 0. 01 ); IL - 12 levels in NPS was significantly higher in RSV - negative Bronchiolitis group [ ( 1214. 5 ± 871. 3 ) ng/L ] than RSV positive Bronchiolitis group [ ( 475. 1 ± 254. 0 ) ng/L ] and the control group [ ( 522. 7 ± 166. 6 ) ng/L ] ( P < 0. 01 ). IL-4 level was significantly higher in atopy positive RSV Bronchiolitis infected infants' NPS [ ( 9. 6 ± 3. 1 ) ng/L ] than in atopy negative infants [ ( 3. 1 ± 1. 5 ) ng/L ] and the control group [ ( 3. 7 ± 1. 5 ) ng/L ] ( P <0. 01 ). While the IL - 12 level in atopy positive RSV Bronchiolitis [ ( 341. 7 ± 132. 9 ) ng/L ] was significantly lower ( P <0. 05 ) than the RSV negative Bronchiolitis group [ ( 675. 2 ± 264. 6 ) ng/L ]. IFN-γ level of atopy positive group [ ( 153. 9 ± 95. 9 ) ng/L ] showed no significantly difference ( P >0. 05 ) compared with that of atopy negative group [ ( 107. 4 ± 39. 3 ) ng/L ] ( P > 0. 05

  10. [Arteriosclerosis obliterans. Treatment with angiotensin-converting enzyme inhibitors].

    Science.gov (United States)

    Orea, A; Valdés, R; Niebla, L; Rivas, R; Camacho, B

    1990-01-01

    We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor. We studied 22 patients: all of them with hypertension and/or skin ulcerations, dropping out those who had venous. They were evaluated periodically, clinically and with photoelectric plethysmography of lower extremities. To interpret the traces we designed an ideogram which gathered the plethysmographic behavior before and after the treatment. Nearly 80% showed considerable improvement in pain, functional capacity and plethysmographic traces patterns. healing of the ulcerations was achieved in all case. We propose some hypothesis to explain the good effect that we have observed.

  11. Organic photovoltaics

    Science.gov (United States)

    Leo, Karl

    2016-08-01

    Organic photovoltaics are on the verge of revolutionizing building-integrated photovoltaics. For other applications, however, several basic open scientific questions need answering to, in particular, further improve energy-conversion efficiency and lifetime.

  12. Multicultural organizations

    DEFF Research Database (Denmark)

    Lauring, Jakob; Selmer, Jan

    2011-01-01

    In recent years the attention towards demographic diversity has increased among academics and practitioners dealing with organization management. Finding a possible connection between diversity and group performance has been the objective of much extant research. Still, however, results are...

  13. Organization Design

    OpenAIRE

    Milton Harris; Artur Raviv

    2002-01-01

    This paper attempts to explain organization structure based on optimal coordination of interactions among activities. The main idea is that each manager is capable of detecting and coordinating interactions only within his limited area of expertise. Only the CEO can coordinate company wide interactions. The optimal design of the organization trades off the costs and benefits of various configurations of managers. Our results consist of classifying the characteristics of activities and manager...

  14. Colloidal organization

    CERN Document Server

    Okubo, Tsuneo

    2015-01-01

    Colloidal Organization presents a chemical and physical study on colloidal organization phenomena including equilibrium systems such as colloidal crystallization, drying patterns as an example of a dissipative system and similar sized aggregation. This book outlines the fundamental science behind colloid and surface chemistry and the findings from the author's own laboratory. The text goes on to discuss in-depth colloidal crystallization, gel crystallization, drying dissipative structures of solutions, suspensions and gels, and similar-sized aggregates from nanosized particles. Special emphas

  15. Organic Conductors

    DEFF Research Database (Denmark)

    Andersen, Jan Rud; Jacobsen, Claus S.; Rindorf, Grethe;

    1975-01-01

    2,3,6,7-Tetramethyl-1,4,5,8-tetraselenafulvalene reacts with 2,5-dimethyl-7,7′,8,8′-tetracyano-p-quinodi-methane to give a highly conducting organic solid.......2,3,6,7-Tetramethyl-1,4,5,8-tetraselenafulvalene reacts with 2,5-dimethyl-7,7′,8,8′-tetracyano-p-quinodi-methane to give a highly conducting organic solid....

  16. The Presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection.

    Directory of Open Access Journals (Sweden)

    Lucy C Sullivan

    Full Text Available The human cytomegalovirus (CMV immune evasion protein, UL40, shares an identical peptide sequence with that found in the leader sequence of many human leukocyte antigen (HLA-C alleles and when complexed with HLA-E, can modulate NK cell functions via interactions with the CD94-NKG2 receptors. However the UL40-derived sequence can also be immunogenic, eliciting robust CD8+ T cell responses. In the setting of solid organ transplantation these T cells may not only be involved in antiviral immunity but also can potentially contribute to allograft rejection when the UL40 epitope is also present in allograft-encoded HLA. Here we assessed 15 bilateral lung transplant recipients for the presence of HLA-E-restricted UL40 specific T cells by tetramer staining of peripheral blood mononuclear cells (PBMC. UL40-specific T cells were observed in 7 patients post-transplant however the magnitude of the response varied significantly between patients. Moreover, unlike healthy CMV seropositive individuals, longitudinal analyses revealed that proportions of such T cells fluctuated markedly. Nine patients experienced low-grade acute cellular rejection, of which 6 also demonstrated UL40-specific T cells. Furthermore, the presence of UL40-specific CD8+ T cells in the blood was significantly associated with allograft dysfunction, which manifested as Bronchiolitis Obliterans Syndrome (BOS. Therefore, this study suggests that minor histocompatibility antigens presented by HLA-E can represent an additional risk factor following lung transplantation.

  17. [Imaging features of drug-induced lung diseases].

    Science.gov (United States)

    Mellot, F; Scherrer, A

    2005-05-01

    Drug-induced lung diseases are an increasingly frequent cause of morbidity. Over 350 drugs are now recognized as being implicated in drug-induced lung diseases. Early diagnosis is critical. Discontinuing the drug may result in regression of the adverse effect. Diagnosis is based on a history of drug exposure with a temporal relationship between the introduction of the drug and the onset of symptoms, histologic evidence of lung damage and exclusion of other causes of lung injury. Unfortunately there is no specific test available. Histologic and radiologic findings are often non specific and diagnosis can be difficult. Drugs can cause a constellation of distinct patterns of respiratory involvement and all anatomic compartments of the lungs may be involved. The most common patterns are: non specific interstitial pneumonia and fibrosis, pulmonary eosinophilia, hypersensitivity pneumonitis, pulmonary edema with or without diffuse alveolar damage, bronchiolitis obliterans organizing pneumonia, pulmonary hemorrhage and vasculitis. It is important to be familiar with their common radiologic appearances. PMID:16106793

  18. Occurrence of BOOP outside radiation field after radiation therapy for small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hamanishi, Tohru; Oida, Kazukiyo [Tenri Hospital, Nara (Japan); Morimatu, Takafumi (and others)

    2001-09-01

    We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) that occurred outside the radiation field after radiation therapy for small cell lung cancer. A 74-year-old woman received chemotherapy and a total of 60 Gy of radiation therapy to the right hilum and mediastinum for small cell carcinoma of the suprahilar area of the right lung. Radiation pneumonitis developed within the radiation port 3 months after the completion of radiation therapy. She complained of cough and was admitted 7 months after completion of the radiation therapy. Chest radiography and computed tomography demonstrated peripheral alveolar opacities outside the radiation field on the side contralateral to that receiving the radiation therapy. Bronchoalveolar lavage showed that the total cell count was increased, with a markedly increased percentage of lymphocytes. Transbronchial lung biopsy revealed a histologic pattern consistent with BOOP. Treatment with corticosteroids resulted in rapid improvement of the symptoms and complete resolution of the radiographic abnormalities of the left lung. Although some cases of BOOP following radiation therapy for breast cancer have been reported, none of BOOP after radiation therapy for lung cancer have appeared in the literature. (author)

  19. Occurrence of BOOP outside radiation field after tangential radiation therapy for breast carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hamanishi, Tohru; Gohma, Iwao; Oida, Kazukiyo [Tenri Hospital, Nara (Japan)] (and others)

    2000-07-01

    We report three cases of bronchiolitis obliterans organizing pneumonia (BOOP) that occurred outside the radiation field after radiation therapy using tangential fields for breast carcinoma. All patients complained of a cough between 14 and 20 weeks after completion of radiation therapy. Fever also developed in two of the three. Chest radiography and computed tomography demonstrated peripheral alveolar opacities outside the radiation field on the same side as the radiation therapy. Laboratory data showed an increased level of C-reactive protein and an increased erythrocyte sedimentation rate. Bronchoalveolar lavage showed an elevated total cell count with a very high percentage of lymphocytes. Transbronchial lung biopsy revealed a histologic pattern consistent with BOOP. Treatment with corticosteroids resulted in rapid clinical improvement and complete resolution of the radiographic abnormalities. This pulmonary disorder appears to be induced by radiation, especially when a tangential field is employed for breast carcinoma, though the etiology has not been fully investigated. It is important to be aware of this type of pulmonary complication in patients given radiotherapy for breast carcinoma. (author)

  20. 气道中心性间质性肺炎%Bronchiocentric interstitial pneumonias

    Institute of Scientific and Technical Information of China (English)

    代华平

    2007-01-01

    许多间质性肺疾病(interstertial lung disease,ILD)的病变都涉及到细支气管,表现为细支气管不同程度的炎症和纤维化,其中表现最为典型的是呼吸性细支气管炎伴间质性肺疾病(respiratory bronchiolitis—ILD,RBILD)、闭塞性细支气管炎伴机化性肺炎(bronchiolitis obliterans organizing pneumonia,BOOP)和过敏性肺炎(hypersensitivity pneumonitis,HP)。此外,结节病、肺郎格尔汉斯细胞组织细胞增生症(pulmonary Langerhans’cell histiocytosis,PLCH)、普通型间质性肺炎(usualinterstitial pneumonia,UIP)等也经常累及细支气管。但是,最近文献先后报道了以特发性细支气管中心性间质性肺炎(idiopathic bronchiolocentric interstitial pneumonia,BrIP)、

  1. Analysis of radiation pneumonitis outside the radiation field in breast conserving therapy for early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ogo, Etsuyo; Fujimoto, Kiminori; Hayabuchi, Naofumi [Kurume Univ., Fukuoka (Japan). School of Medicine] (and others)

    2002-02-01

    In a retrospective study of radiation-induced pulmonary changes for patients with breast conserving therapy for early breast cancer, we sent questionnaires to the main hospitals in Japan. In this study, we analyzed pulmonary changes after tangential whole-breast irradiation. The purpose of this study was to determine the incidence and risk factors for radiation pneumonitis outside the radiation field. The questionnaires included patients data, therapy data, and lung injury information between August 1999 and May 2000. On the first questionnaires, answer letters were received from 107 institutions out of 158 (67.7%). On the second questionnaires, response rate (hospitals which had radiation pneumonitis outside the radiation field) was 21.7% (23/106). We could find no risk factors of this type of pneumonitis. We suggested that lung irradiation might trigger this type of pneumonitis which is clinically similar to BOOP (bronchiolitis obliterans organizing pneumonia). It developed in 1.5-2.1% among the patients with breast conserving surgery and tangential whole-breast irradiation. And it is likely appeared within 6 months after radiotherapy. (author)

  2. Analysis of radiation pneumonitis outside the radiation field in breast conserving therapy for early breast cancer

    International Nuclear Information System (INIS)

    In a retrospective study of radiation-induced pulmonary changes for patients with breast conserving therapy for early breast cancer, we sent questionnaires to the main hospitals in Japan. In this study, we analyzed pulmonary changes after tangential whole-breast irradiation. The purpose of this study was to determine the incidence and risk factors for radiation pneumonitis outside the radiation field. The questionnaires included patients data, therapy data, and lung injury information between August 1999 and May 2000. On the first questionnaires, answer letters were received from 107 institutions out of 158 (67.7%). On the second questionnaires, response rate (hospitals which had radiation pneumonitis outside the radiation field) was 21.7% (23/106). We could find no risk factors of this type of pneumonitis. We suggested that lung irradiation might trigger this type of pneumonitis which is clinically similar to BOOP (bronchiolitis obliterans organizing pneumonia). It developed in 1.5-2.1% among the patients with breast conserving surgery and tangential whole-breast irradiation. And it is likely appeared within 6 months after radiotherapy. (author)

  3. Sirolimus-associated interstitial pneumonitis in a liver transplant recipient

    International Nuclear Information System (INIS)

    Sirolimus is an immunosuppressive drug that has been used during the past few years. Sirolimus is indicated in rescue therapies and to reduce the secondary toxic effects of calcineurin inhibitors. This drug has been associated with infrequent but severe pulmonary toxicity. Cases of interstitial pneumonitis, bronchiolitis obliterans with organizing pneumonia, and alveolar proteinosis have been described. We describe a case of pulmonary toxicity associated with the use of sirolimus in a 59-yr-old liver transplant recipient. We also review all reported cases of sirolimus-associated lung toxicity among liver transplantation recipients, with the intention of understanding the risk factors, the clinical picture and the outcomes of this complication. Five cases have been reported since January 2000, including the present case. Clinical presentation is similar, with fever, dyspnoea, fatigue, cough, and hemoptysis. Discontinuation of the drug led to resolution of clinical and radiographic findings. Sirolimus-induced pulmonary toxicity is a serious condition and should be considered in the differential diagnosis of liver recipients presenting with respiratory findings. Discontinuation of the drug is associated with resolution of the pulmonary compromise

  4. Ground-glass opacity at high resolution CT: an approach for differential diagnosis

    International Nuclear Information System (INIS)

    Purpose: To evaluate the Ground-Glass Opacity in high resolution computed tomography (HRCT) with its underlying abnormality and anatomic distribution and its correlation with different etiologies. Methods: A 38 patients series, (32 men, 16 women, mean age 54,6 years, range 20-28) was retrospectively analyzed. They were evaluated with high resolution computed tomography, 2 mm thick sections and 10 mm of interval. Contrast intravenous iodinated contrast (no-ionic) was injected in 11 patients. The final diagnosis was made with sputum analysis, bronchioalveolar lavage, trans bronchial biopsy and open lung biopsy. Results: The differential diagnosis of ground glass opacity is based on analyzing their anatomic resolution and the underlying pathology in the lung parenchyma. Centrilobular distribution indicated early air-spaces pathology produced in our series by 21 infections, 4 pulmonary hemorrhages, 1 hypersensitivity pneumonitis and 1 descamative interstitial pneumonitis. Panlobular distribution, alveolar proteinosis (1 case) sarcoidosis (1 case) drug toxicity 1 case and one case of pneumocystis carinii. Peripherical distribution typical of early idiopathic fibrosis (1). Bronchiolitis obliterans with organizing pneumonia (1). Structural alterations of the lung parenchyma with bronchiectasias was seen in 16 cases, cystic lesions in 3 cases, sub pleural linear opacities 4 cases, peribronchovascular interstitial thickening or nodularity and emphysema in 10 cases. Conclusion: HRCT is useful to evaluate ground glass opacities pattern with the anatomic distribution and the underlying structural pathology. These findings under some clinical circumstances can suggest a specific diagnosis in most cases, indicating a potentially treatable disease. (author)

  5. Cytomegalovirus Immunoglobulin After Thoracic Transplantation

    Science.gov (United States)

    Grossi, Paolo; Mohacsi, Paul; Szabolcs, Zoltán; Potena, Luciano

    2016-01-01

    Abstract Cytomegalovirus (CMV) is a highly complex pathogen which, despite modern prophylactic regimens, continues to affect a high proportion of thoracic organ transplant recipients. The symptomatic manifestations of CMV infection are compounded by adverse indirect effects induced by the multiple immunomodulatory actions of CMV. These include a higher risk of acute rejection, cardiac allograft vasculopathy after heart transplantation, and potentially bronchiolitis obliterans syndrome in lung transplant recipients, with a greater propensity for opportunistic secondary infections. Prophylaxis for CMV using antiviral agents (typically oral valganciclovir or intravenous ganciclovir) is now almost universal, at least in high-risk transplants (D+/R−). Even with extended prophylactic regimens, however, challenges remain. The CMV events can still occur despite antiviral prophylaxis, including late-onset infection or recurrent disease, and patients with ganciclovir-resistant CMV infection or who are intolerant to antiviral therapy require alternative strategies. The CMV immunoglobulin (CMVIG) and antiviral agents have complementary modes of action. High-titer CMVIG preparations provide passive CMV-specific immunity but also exert complex immunomodulatory properties which augment the antiviral effect of antiviral agents and offer the potential to suppress the indirect effects of CMV infection. This supplement discusses the available data concerning the immunological and clinical effects of CMVIG after heart or lung transplantation. PMID:26900989

  6. Virtual Organizations: Beyond Network Organization

    Directory of Open Access Journals (Sweden)

    Liviu Gabriel CRETU

    2006-01-01

    Full Text Available One of the most used buzz-words in (e-business literature of the last decade is virtual organization. The term "virtual" can be identified in all sorts of combinations regarding the business world. From virtual products to virtual processes or virtual teams, everything that is “touched” by the computer’s processing power instantly becomes virtual. Moreover, most of the literature treats virtual and network organizations as being synonyms. This paper aims to draw a much more distinctive line between the two concepts. Providing a more coherent description of what virtual organization might be is also one of our intentions.

  7. Chest physical therapy is effective in reducing the clinical score in bronchiolitis: randomized controlled trial A fisioterapia respiratória é eficaz na redução de escore clínico na bronquiolite: ensaio controlado randomizado

    Directory of Open Access Journals (Sweden)

    Évelim L. F. D. Gomes

    2012-06-01

    Full Text Available OBJECTIVE: To evaluate the effectiveness of chest physical therapy (CP in reducing the clinical score in infants with acute viral bronchiolitis (AVB. METHODS: Randomized controlled trial of 30 previously healthy infants (mean age 4.08 SD 3.0 months with AVB and positive for respiratory syncytial virus (RSV, evaluated at three moments: at admission, then at 48 and 72 hours after admission. The procedures were conducted by blinded assessors to each of three groups: G1 - new Chest Physical therapy- nCPT (Prolonged slow expiration - PSE and Clearance rhinopharyngeal retrograde - CRR, G2 - conventional Chest Physical therapy- cCPT (modified postural drainage, expiratory compression, vibration and percussion and G3 - aspiration of the upper airways. The outcomes of interest were the Wang's clinical score (CS and its components: Retractions (RE, Respiratory Rate (RR, Wheezing (WH and General Conditions (GC. RESULTS: The CS on admission was reduced in G1 (7.0-4.0 and G2 (7.5-5.5 but was unchanged in G3 (7.5-7.0. We observed a change 48 hours after hospitalization in G1 (5.5-3.0 and G2 (4.0-2.0 and in 72 hours, there was a change in G1 (2.0-1.0. CONCLUSION: The CP was effective in reducing the CS in infants with AVB compared with upper airway suction only. After 48 hours of admission, both techniques were effective and nCPT techniques were also effective in the 72 hours after hospitalization compared with cCPT techniques.OBJETIVO: Avaliar a efetividade da fisioterapia respiratória na redução do escore clínico em lactentes com bronquiolite viral aguda (BVA. MÉTODOS: Ensaio controlado randomizado de 30 lactentes (média de idade 4,08±3,12 meses com BVA, previamente hígidos, com vírus sincicial respiratório (VSR positivo, avaliados em três momentos: admissão, 48 e 72 horas, antes e após os procedimentos por avaliadores cegos, em três grupos: G1 - técnicas atuais de fisioterapia (expiração lenta e prolongada e desobstrução rinofar

  8. 孟鲁司特联合布地奈德治疗毛细支气管炎的临床疗效观察%Clinical Effect of Montelukast and Budesonide in Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    宫英方; 杨海明

    2012-01-01

    Objective: To observe the clinical effect of montelukast combined with budesonide in bronchiolitis. Methods: Ninety cases of children with capillarybronchitis were randomly divided into the experimental group (48 cases) and the control group (42 cases). 40 healthy children were selected as normal control group. Both the experimental group and the control group were given traditional therapy. The experimental group received montelukast (< 6 months, 2 mg/d; 6-18 months, 4 mg/d, orally at bedtime) and budesonide suspension, 1 mL/time, twice a day till the symptoms were disappeared, then continued to take montelukast for one week. The disappearance time of symptoms and physical signs, the length of hospital stay and the cure rate were compared and analyzed between the two groups. And the changes of IgE, IL-4 and Eos in serum before and after treatment were observed. The difference was compared between the experimental group, the control group and the normal control group. Results: The cure rate of the experimental group was 91. 1% , and that of the control group was 69. 0%. The difference between these two groups was statistically significant (X2 =7.48, P<0. 01). The experimental group was superior to the control group in shortening the length of hospital stay, relieving and shortening the degree and the time of wheezing and coughs. Their differences were statistically significant (P<0. 05). The expression levels of IgE, IL-4 and Eos in serum after treatment were significantly lower than those before treatment (P<0.01) , especially in the experimental group (P<0.05). Conclusions: Combined therapy of montelukast and budesonide used for treatment of capillary bronchitis in children can significantly enhance clinical effect and reduce complications, so it deserved clinical application.%目的:观察口服孟鲁司特联合布地奈德雾化吸入治疗毛细支气管炎的疗效.方法:将临床确诊为婴幼儿毛细支气管炎的90例患儿随机分为试验组48

  9. Entangled Organizations

    DEFF Research Database (Denmark)

    Strand, Anete Mikkala Camille

    The paper accounts for the process of becoming of a changed practice within the area of disability care in the Municipality of Aalborg in Denmark. Across a period of a few months in the fall of 2015 a group of employees across the organization and an action researcher from Aalborg University (the...... author) met and formed a research group and across this period a revised model for cooperation emerged that – upon realization – would reconfigure the intra-play of all relevant areas of the organization involved in disability care. The model included the grasping of disability as dis/ability and thereby...... for the employees and thereby support the bringing about of a cultural transformation. A changed relationality indeed brought about though reworking the binary dis/able. From the standpoint of a diffractive methodology (Barad 2007) the paper accounts for this project by being organized in four parts that together...

  10. Organ culture

    DEFF Research Database (Denmark)

    Alm, Rikard; Edvinsson, Lars; Malmsjö, Malin

    2002-01-01

    BACKGROUND: Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction. METHODS: The isometric tension was recorded in isolated segments...... of the rat mesenteric artery branch, before and after organ culture for 20 h. Vasodilatation was expressed as % of preconstriction with U46619. The acetylcholine (ACh) induced nitric oxide (NO) mediated dilatation was studied in the presence of 10 microM indomethacin, 50 nM charybdotoxin and 1 microM apamin....... Endothelium-derived hyperpolarising factor (EDHF) was studied in the presence of 0.1 mM L-NOARG and indomethacin. Prostaglandins were studied in the presence of L-NOARG, charybdotoxin and apamin. RESULTS: The ACh-induced NO and prostaglandin-mediated dilatations decreased significantly during organ culture...

  11. Organic Computing

    CERN Document Server

    Würtz, Rolf P

    2008-01-01

    Organic Computing is a research field emerging around the conviction that problems of organization in complex systems in computer science, telecommunications, neurobiology, molecular biology, ethology, and possibly even sociology can be tackled scientifically in a unified way. From the computer science point of view, the apparent ease in which living systems solve computationally difficult problems makes it inevitable to adopt strategies observed in nature for creating information processing machinery. In this book, the major ideas behind Organic Computing are delineated, together with a sparse sample of computational projects undertaken in this new field. Biological metaphors include evolution, neural networks, gene-regulatory networks, networks of brain modules, hormone system, insect swarms, and ant colonies. Applications are as diverse as system design, optimization, artificial growth, task allocation, clustering, routing, face recognition, and sign language understanding.

  12. 呼吸道合胞病毒毛细支气管炎患儿血和痰中白三烯测定及临床意义%The blood and sputum levels of leukotriene in children with respiratory syncytial viral bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    易阳; 钟闻燕; 熊建新; 钱金强; 虞斌; 涂国华; 姚圣连

    2011-01-01

    Objective To investigate the effects of leukotriene in children with respiratory syncytial (RSV)viral bronchiolitis.Methods The blood and sputum levels of Ieukotriene were detected in 33 cases diagnosed RSV bronchiolitis and 12 cases which were diagnosed pneumonia without RSV infection.Thirty-three cases of bronchiolitis were devided into mild-moderate group(n =22)and severe group(n =11)according to the lowell score.Results The blood and sputum levels of leukotriene in mild-moderate group,severe group,and pneumonia group were(76.96 ± 28.19)pg/ml,(103.53 ± 16.85)pg/ml,(18.14.± 7.49)pg/ml;(31.83 ± 19.14)pg/ml,(67.11 ± 15.11)pg/ml,(6.81 ± 2.90)pg/ml in acute period,and(36.04 ±16.38)pg/ml,(52.27 ± 17.03)pg/m l,(18.14 ± 7.49)pg/ml of serum in recovery period.There were significant differences among three groups(F =48.09,P < 0.001 ; F =15.50,P < 0.001 ; F =44.43,P <0.001).After treatment,the blood levels of leukotriene were significantly decreased,but were still higher than that of pneumonia group(P < 0.05).Conclusion The blood and sputum levels of leukotriene increase in children with RSV bronchiolitis,which is related with the severity of bronchiolitis.%目的 探讨呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎(毛支炎)患儿血、痰中白三烯C4(leukotriene C4,LTC4)水平的变化及临床意义.方法轻-中度毛支炎组22例,重度毛支炎组11例,另选择无喘息非RSV感染性肺炎患儿12例作为对照(肺炎组).采用双抗体夹心酶联免疫吸附试验测定血清和痰中LTC4水平,并进行对比分析.结果急性期轻-中度毛支炎组、重度毛支炎组、肺炎组血清LTC4水平分别为(76.96±28.19)pg/ml、(103.53±16.85)pg/ml、(18.14±7.49)pg/ml;痰中LTC4水平分别为(31.83±19.14)pg/ml、(67.11±15.11)pg/ml、(6.81±2.90)pg/ml;恢复期血清LTC4水平分别为(36.04±16.38)pg/ml、(52.27±17.03)pg/ml、(18.14±7.49)pg/ml,3组间差异有统计学意义(F=48.09,P<0.001;F=15.50,P

  13. The effect of leukotriene receptor antagonist on respiratory syncytial virus RSV bronchiolitis and the balance of Thl/Th2%白三烯受体拮抗剂对呼吸道合胞病毒性毛细支气管炎 Thl/Th2细胞平衡的影响

    Institute of Scientific and Technical Information of China (English)

    陈建江; 黄肖梅; 万学凌

    2015-01-01

    目的:探讨白三烯受体拮抗剂对呼吸道合胞病毒(RSV)毛细支气管炎气道炎症的作用及对毛细支气管炎后发生哮喘倾向的预防作用。方法选择2012年6月-2014年5月医院内儿科住院的轻中度 RSV 毛细支气管炎患儿186例,随机分为顺尔宁干预组69例,均予孟鲁司特钠(顺尔宁);激素干预组65例,予布地奈德混悬液氧;空白对照组52例,不予任何干预治疗。同时选择30例同期在儿童保健门诊做健康体检的婴幼儿为健康对照组。分别在住院当日、干预前、干预后抽取静脉血,ELISA 试剂盒检测各组患者血清γ-IFN、IL-12、IL-13及 LTE4的浓度,门诊随访1年。结果 RSV 毛细支气管炎患儿 IL-13及 LTE4水平在急性期、恢复期明显升高,而 IL-12及γ-IFN 水平降低。顺尔宁干预组及激素干预组患儿干预结束后 IL-13、LTE4水平均下降,IL-12、γ-IFN 水平上升,其水平基本恢复至正常;顺尔宁干预组及激素干预组患儿干预结束后 LTE4水平较干预前明显下降,顺尔宁干预组基本恢复至正常水平,但激素干预组未恢复至正常水平;顺尔宁干预组喘息再次发作率明显减少,差异均有统计学意义( P <0.05)。结论白三烯受体拮抗剂能够调节 Thl/ Th2的失衡,减少 LTE4的释放,降低嗜酸性粒细胞的活化程度,减轻气道炎症和气道高反应性,减少喘息发作,对呼吸道合胞病毒性毛细支气管炎后发生哮喘倾向有积极的预防作用。%Objective To explore the effect of leukotriene receptor antagonist on respiratory syncytial virus RSV bron-chiolitis airway inflammation and the preventive effect of it on asthma after bronchiolitis. Methods 186 cases of children with respiratory syncytial virus RSV bronchiolitis in our hospital were randomly divided into three groups:the intervention group of singulair was treated with oral montelukast soudium tablets(69 cases

  14. Entangling Organizations

    DEFF Research Database (Denmark)

    Strand, Anete Mikkala Camille

    2016-01-01

    The chapter accounts for the process of becoming of a changed practice within the area of disability care in the Municipality of Aalborg in Denmark. Across a period of a few months in the fall of 2015 a group of employees across the organization and an action researcher from Aalborg University (the...... author) met and formed a research- practice group and across this period a revised model for cooperation emerged that – upon realization – would reconfigure the intra-play of all relevant areas of the organization involved in disability care. The model included the grasping of disability as dis...

  15. Designing Organizations

    DEFF Research Database (Denmark)

    DESIGNING ORGANIZATIONS: 21st Century Approaches er en vigtig publikation inden for organisationsdesign. Fokus ligger på nye udviklinger inden for organisationsdesign og bogen hjælper med at skabe mere reflekterende forskining og stærkere empiriske analyser inden for dette vigtige felt inden...

  16. 4.3%高渗盐水加复方异丙托溴铵治疗毛细支气管炎疗效观察%Observation of the effects of 4.3%Hypertonic Saline and Compound Ipratropium Bromide Inhalation in treating Bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    张高杰

    2013-01-01

    Objective:To investigate atomization inhalation 4.3%hypertonic saline and suction with compound ipratropium bromide atomizing solution treatment the curative effect of bronchiolitis.Methods:93 cases of children with bronchiolitis divided into treatment group and control group and treatment group,47 patients with aerosolized 4.3% hypertonic saline 1.5 ml and suction with compound ipratropium bromide atomizing solution 1.5 mlq8h until discharge;46 cases of control group,atomization inhalation physiological saline 1.5 ml and suction with compound ipratropium bromide atomizing solution 1.5 MLQ 8h until discharge,compare two groups of children to asthma,cough,pulmonary symptoms change and day in hospital.Results:Two groups of patients were cured and discharged,the treatment group take suppress,cough,pulmonary symptoms relieve time and average hospitalization is control group significantly shortened (P<0.01). Conclusion:Aerosol inhalation of 4.3% hypertonic saline and suction with compound ipratropium bromide ammonia spray solution treatment baby bronchiolitis enhance curative effect,shorten the period of treatment,safe and effective.%目的::探讨雾化4.3%高渗盐水加吸入用复方异丙托溴铵雾化溶液治疗毛细支气管炎的疗效。方法:将93例毛细支气管炎患儿分成治疗组和对照组,治疗组47例,雾化吸入4.3%高渗盐水1.5ml加吸入用复方异丙托溴铵雾化溶液1.5mlq8h直至出院;对照组46例,雾化吸入生理盐水1.5ml加吸入用复方异丙托溴铵雾化溶液1.5mlq 8 h直至出院,比较两组患儿喘憋、咳嗽、肺部体征变化情况及住院日。结果:两组患儿均治愈出院,治疗组喘憋、咳嗽、肺部体征缓解时间及住院日均较对照组明显缩短(P<0.01)。结论:雾化吸入4.3%高渗盐水加吸入用复方异丙托溴氨雾化溶液治疗婴儿毛细支气管炎增强疗效,缩短疗程,安全、有效。

  17. Effect of budesonide atomization inhalation combined with mechanical vibration sputum in bronchiolitis%布地奈德雾化吸入联合机械振动排痰佐治毛细支气管炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    焦君

    2013-01-01

    Objective To observe the therapeutic effect of budesonide atomization inhalation with mechanical vibration sputum elimination for bronchiolitis .Methods One hundred and twenty -five cases with bronchiolitis were divided into treatment group(n= 65) and control group(n= 60)by a random number table method .The contrast group were treated with conventional treatment combined with atomization inhalation given 5-10 min/time ,2-3/d , for 3-5 d .The treatment group were treated with budesonide suspension (0 .5 mg each) with mechanical vibration sputum given 5-10 min/time ,2/d for 3-5 d .Results Compared with the control group ,the time of asthma relie-ving ,wheezing ,pulmonary rales ,and cough and the length of hospital days of the treatment group were significant shorter than those of the control group (P<0 .01) .The total effective rate in treatment group (93 .85% )was signifi-cant higher than that in the control group (81 .67% ) .The difference was significant ( P< 0 .05 ,χ2 = 4 .38 ) . Conclusion The treatment of budesonide atomization inhalation with mechanical vibration sputum for bronchiolitis is a safe effective adjuvant therapy .%目的:探讨布地奈德混悬液(布地奈德)雾化吸入联合机械振动排痰佐治毛细支气管炎的疗效。方法125例毛细支气管炎患儿采用随机数表法分为治疗组(65例)和对照组(60例)。对照组在常规综合治疗基础上使用机械振动排痰治疗,5~10分钟/次,2次/天,疗程3~5 d ;治疗组给予雾化吸入布地奈德混悬液0.5毫克/次,5~10分钟/次,2次/天,联合机械振动排痰进行治疗,疗程3~5 d 。结果治疗组喘憋、哮鸣音、肺部啰音、咳嗽消失时间及住院时间均优于对照组,差异有统计学意义( P<0.01),治疗组和对照组总有效率分别为93.85%和81.67%,差异有统计学意义( P<0.05,χ2=4.38)。结论布地奈德雾化吸入联合机械振动排痰辅助治疗

  18. 毛细支气管炎患儿单核细胞Toll样受体-4的表达与维生素D水平变化的关系%Relationship between the expression of Toll-like receptor 4 on mononuclear cells in peripheral blood and changes of serum vitamin D level in children with bronchiolitis

    Institute of Scientific and Technical Information of China (English)

    吴奎; 袁北芳; 侯学敬; 李超; 任立红

    2015-01-01

    目的 探讨毛细支气管炎患儿外周血中单核细胞Toll样受体-4(TLR4)的表达与血清维生素D水平变化的关系.方法 选取2013年10月至2014年1月在哈尔滨医科大学附属第二临床医院住院诊治的毛细支气管炎患儿为治疗前组,再根据病情分为轻中度和重度2组,每组20例;将治疗后好转的病例设为治疗后组,以同期在哈尔滨医科大学附属第二临床医院保健门诊体检的健康儿童30例为健康对照组.流式细胞术检测外周血中CD14标记的单核细胞表达的TLR4,酶联免疫吸附试验(ELISA)检测血清中25羟维生素D[25(OH)D]水平.结果 1.毛细支气管炎患儿治疗前单核细胞TLR4的表达水平:轻中度组[(18.98±2.29)%]、重度组[(30.13±2.13)%]较健康对照组[(1.17±0.57)%]显著增高(P<0.05);治疗后水平:轻中度组[(2.02±0.48)%]、重度组[(11.43 ±1.52)%]比治疗前下降(P<0.05).2.毛细支气管炎患儿治疗前血清维生素D水平:轻中度组[(17.16±3.34) μg/L]、重度组[(6.56±2.28) μg/L]较健康对照组[(53.69±20.18)μg/L]显著降低,而治疗前重度组[(6.56±2.28) μg/L]更低(P<0.05);治疗后维生素D水平:轻中度组[(9.59 ±2.31) μg/L]、重度组[(4.70±0.67) μg/L]比治疗前降低(P<0.05).3.毛细支气管炎患儿治疗前重度组(r=-0.491,P<0.05)和治疗后轻中度组(r=-0.436,P<0.05)外周血单核细胞表达TLR4与血清25 (OH)D水平呈负相关,而健康对照组、治疗前轻中度组及治疗后重度组无相关性(P>0.05).结论 毛细支气管炎患儿病情与TLR4表达水平呈正相关,与维生素D水平呈负相关,在治疗过程中血清25(OH)D持续下降.毛细支气管炎患儿单核细胞TLR4表达与维生素D水平具有一定的相关性.%Objective To investigate the relationship between the expression of Toll-like receptor 4 (TLR4) on mononuclear cells in peripheral blood and changes of serum vitamin D level in children with bronchiolitis

  19. Organic photovoltaics

    DEFF Research Database (Denmark)

    Demming, Anna; Krebs, Frederik C; Chen, Hongzheng

    2013-01-01

    Energy inflation, the constant encouragement to economize on energy consumption and the huge investments in developing alternative energy resources might seem to suggest that there is a global shortage of energy. Far from it, the energy the Sun beams on the Earth each hour is equivalent to a year......'s supply, even at our increasingly ravenous rate of global energy consumption [1]. But it's not what you have got it's what you do with it. Hence the intense focus on photovoltaic research to find more efficient ways to harness energy from the Sun. Recently much of this research has centred on organic...... solar cells since they offer simple, low-cost, light-weight and large-area flexible photovoltaic structures. This issue with guest editors Frederik C Krebs and Hongzheng Chen focuses on some of the developments at the frontier of organic photovoltaic technology. Improving the power conversion efficiency...

  20. Organic Compounds

    Science.gov (United States)

    Shankland, Kenneth

    For many years, powder X-ray diffraction was used primarily as a fingerprinting method for phase identification in the context of molecular organic materials. In the early 1990s, with only a few notable exceptions, structures of even moderate complexity were not solvable from PXRD data alone. Global optimisation methods and highly-modified direct methods have transformed this situation by specifically exploiting some well-known properties of molecular compounds. This chapter will consider some of these properties.

  1. Organic superconductors

    OpenAIRE

    Lang, Michael; Mueller, Jens

    2003-01-01

    This article will give an overview on the normal- and superconducting-state properties of organic superconductors. There are a number of review articles on this subject - most of them focus on either the quasi-one-dimensional or two-dimensional materials. The intention of the present review is therefore to provide a discussion which covers aspects common to both families on the same footing. Instead of reviewing the whole diversity of behaviors found among the various compounds with all their...

  2. Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children

    Directory of Open Access Journals (Sweden)

    EY Chan

    2005-01-01

    Full Text Available Idiopathic nontransplant-related childhood bronchiolitis obliterans is an uncommon disease. Most patients present with chronic recurrent dyspnea, cough and wheezing, which are also features of asthma, by far a much more common condition. The present case study reports on a six-year-old girl who presented to a tertiary care centre with recurrent episodes of respiratory distress on a background of baseline tachypnea, chronic hypoxemia and exertional dyspnea. Her past medical history revealed significant lung disease in infancy, including respiratory syncytial virus bronchiolitis and repaired gastroesophageal reflux. She was treated for 'asthma exacerbations' throughout her early childhood years. Bronchiolitis obliterans was subsequently diagnosed with an open lung biopsy. She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. Treatment options remain a dilemma for this patient because there is no known effective treatment for this condition, and the natural history is not well understood. The present case demonstrates the need for careful workup in 'atypical asthma', and the urgent need for further research into the rare lung diseases of childhood.

  3. LEARNING ORGANIZATIONS: PREREQUISITE FOR SUCCESSFUL TOURISM ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Natasa Kraleva

    2011-06-01

    Full Text Available Nowadays, each and every organization, including the tourism organizations should be learning organizations. The globalization and the competition affect the process of working of tourism organizations, where only the organizations which have knowledge, and are learning organizations can succeed. In a time of constant change, tourism organizations can have a competitive advantage only if they can do something or offer something different than their competitors. Many organizations in order to enable the learning process, should firstly undertake changes in the organization design, the organizational culture and the leadership style. The paper discusses the relevance of implementing the process of learning organizations as a concept for successful tourism organizations.

  4. LEARNING ORGANIZATIONS: PREREQUISITE FOR SUCCESSFUL TOURISM ORGANIZATIONS

    OpenAIRE

    Natasa Kraleva

    2011-01-01

    Nowadays, each and every organization, including the tourism organizations should be learning organizations. The globalization and the competition affect the process of working of tourism organizations, where only the organizations which have knowledge, and are learning organizations can succeed. In a time of constant change, tourism organizations can have a competitive advantage only if they can do something or offer something different than their competitors. Many organizations in order to ...

  5. Organic photovoltaics

    Science.gov (United States)

    Demming, Anna; Krebs, Frederik C.; Chen, Hongzheng

    2013-12-01

    Energy inflation, the constant encouragement to economize on energy consumption and the huge investments in developing alternative energy resources might seem to suggest that there is a global shortage of energy. Far from it, the energy the Sun beams on the Earth each hour is equivalent to a year's supply, even at our increasingly ravenous rate of global energy consumption [1]. But it's not what you have got it's what you do with it. Hence the intense focus on photovoltaic research to find more efficient ways to harness energy from the Sun. Recently much of this research has centred on organic solar cells since they offer simple, low-cost, light-weight and large-area flexible photovoltaic structures. This issue with guest editors Frederik C Krebs and Hongzheng Chen focuses on some of the developments at the frontier of organic photovoltaic technology. Improving the power conversion efficiency of organic photovoltaic systems, while maintaining the inherent material, economic and fabrication benefits, has absorbed a great deal of research attention in recent years. Here significant progress has been made with reports now of organic photovoltaic devices with efficiencies of around 10%. Yet operating effectively across the electromagnetic spectrum remains a challenge. 'The trend is towards engineering low bandgap polymers with a wide optical absorption range and efficient hole/electron transport materials, so that light harvesting in the red and infrared region is enhanced and as much light of the solar spectrum as possible can be converted into an electrical current', explains Mukundan Thelakkat and colleagues in Germany, the US and UK. In this special issue they report on how charge carrier mobility and morphology of the active blend layer in thin film organic solar cells correlate with device parameters [2]. The work contributes to a better understanding of the solar-cell characteristics of polymer:fullerene blends, which form the material basis for some of the most

  6. Organizing Process

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer; Bojesen, Anders

    This paper invites to discuss the processes of individualization and organizing being carried out under what we might see as an emerging regime of change. The underlying argumentation is that in certain processes of change, competence becomes questionable at all times. The hazy characteristics...... of this regime of change are pursued through a discussion of competencies as opposed to qualifications illustrated by distinct cases from the Danish public sector in the search for repetitive mechanisms. The cases are put into a general perspective by drawing upon experiences from similar change processes...

  7. Evolução e característica de lactantes com bronquiolite viral aguda submetidos à ventilação mecânica em uma unidade de terapia intensiva pediátrica brasileira Outcome and characteristics of infants with acute viral bronchiolitis submitted to mechanical ventilation in a Brazilian pediatric intensive care

    Directory of Open Access Journals (Sweden)

    Fernanda Umpierre Bueno

    2009-06-01

    bronquiolite viral aguda.OBJECTIVE: To describe the characteristics and the outcome of infants with acute viral bronchiolitis submitted to mechanical ventilation. METHODS: We performed a retrospective study enrolling all infants (less than 12 months old admitted with the diagnosis of acute viral bronchiolitis and submitted to mechanical ventilation in an university affiliated Brazilian pediatric intensive care unit between March, 2004 and September, 2006 (3 consecutives winters. The mechanical ventilation parameters' employed on 1st, 2nd, 3rd, 7th day and before extubation were evaluated as well as the evolution (mortality rate, presence of acute respiratory distress syndrome and the prevalence of complications. The groups were compared using the Student t test, the Mann-Whitney U test and the Chi-square test. RESULTS: Fifty-nine infants were included (3.8 ± 2.7 months old, 59% male, with 9.0 ± 9.4 days on mechanical ventilation. Prior mechanical ventilation, non invasive ventilation was instituted in 71% of children. Anemia was observed in 78% of the sample. In 51 infants (86.5% the lower airway obstructive pattern was maintained up to tracheal extubation with a nil mortality and low prevalence of pneumothorax (7.8%. Acute respiratory distress syndrome occurred in 8 infants (13.5%, with higher mortality and a higher prevalence of pneumothorax (62.5%. CONCLUSIONS: The declining mortality in acute viral bronchiolitis is observed even in non developed regions, involving children with high rates of anemia and premature labor. The low mortality is associated with the maintenance of the lower airway obstructive pattern during the period on mechanical ventilation. The development of acute respiratory distress syndrome is associated with increased mortality and higher prevalence of complications, representing the actual challenge in the management of children with severe acute viral bronchiolitis.

  8. History of deceased organ donation, transplantation, and organ procurement organizations.

    Science.gov (United States)

    Howard, Richard J; Cornell, Danielle L; Cochran, Larry

    2012-03-01

    The historical development of deceased organ donation, transplantation, and organ procurement organizations is reviewed. The concept of transplantation, taking parts from one animal or person and putting them into another animal or person, is ancient. The development of organ transplantation brought on the need for a source of organs. Although many early kidney transplants used kidneys from living donors, these donors could not satisfy the ever-growing need for organs, and extrarenal organs were recovered only from deceased donors. This need for organs to satisfy the great demand led to specialized organizations to identify deceased donors, manage them until recovery occurred, and to notify transplant centers that organs were available for their patients. The functions of these organ procurement organizations expanded to include other required functions such as education, accounting, and compliance with state and federal requirements. Because of the shortage of organs relative to the demand, lack of a unified organ allocation system, the perception that organs are a national resource and should be governed by national regulations, and to improve results of organ procurement organizations and transplant centers, the federal government has regulated virtually all phases of organ procurement and transplantation. PMID:22489438

  9. Organic photovoltaics

    Science.gov (United States)

    Demming, Anna; Krebs, Frederik C.; Chen, Hongzheng

    2013-12-01

    Energy inflation, the constant encouragement to economize on energy consumption and the huge investments in developing alternative energy resources might seem to suggest that there is a global shortage of energy. Far from it, the energy the Sun beams on the Earth each hour is equivalent to a year's supply, even at our increasingly ravenous rate of global energy consumption [1]. But it's not what you have got it's what you do with it. Hence the intense focus on photovoltaic research to find more efficient ways to harness energy from the Sun. Recently much of this research has centred on organic solar cells since they offer simple, low-cost, light-weight and large-area flexible photovoltaic structures. This issue with guest editors Frederik C Krebs and Hongzheng Chen focuses on some of the developments at the frontier of organic photovoltaic technology. Improving the power conversion efficiency of organic photovoltaic systems, while maintaining the inherent material, economic and fabrication benefits, has absorbed a great deal of research attention in recent years. Here significant progress has been made with reports now of organic photovoltaic devices with efficiencies of around 10%. Yet operating effectively across the electromagnetic spectrum remains a challenge. 'The trend is towards engineering low bandgap polymers with a wide optical absorption range and efficient hole/electron transport materials, so that light harvesting in the red and infrared region is enhanced and as much light of the solar spectrum as possible can be converted into an electrical current', explains Mukundan Thelakkat and colleagues in Germany, the US and UK. In this special issue they report on how charge carrier mobility and morphology of the active blend layer in thin film organic solar cells correlate with device parameters [2]. The work contributes to a better understanding of the solar-cell characteristics of polymer:fullerene blends, which form the material basis for some of the most

  10. Organic Nanowires

    DEFF Research Database (Denmark)

    Balzer, Frank; Schiek, Manuela; Al-Shamery, Katharina;

    Single crystalline nanowires from fluorescing organic molecules like para-phenylenes or thiophenes are supposed to become key elements in future integrated optoelectronic devices [1]. For a sophisticated design of devices based on nanowires the basic principles of the nanowire formation have...... to be well understood [2]. Nanowires from para-phenylenes, from ®-thiophenes, and from phenylene/thiophene co-oligomers, Fig. 1, are investigated exemplarily. Epitaxy and electrostatic interactions determine the microscopic growth mechanism, whereas kinetics ascertains the macroscopic habit. Results from...... atomic force microscopy and from polarized far-field optical microscopy for various prototypical molecules are reproduced by electrostatic and Monte Carlo calculations. Based on the crystal structure, predictions on the growth habit from other conjugated molecules become in reach....

  11. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    International Nuclear Information System (INIS)

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  12. High-resolution CT in patients with chronic airflow obstruction: correlation with clinical diagnosis and pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ki Taek; Kang, Eun Young; Rhee, Ji Yong; Kim, Jin Hyung; Choi, Jung Ah; Cho, Jae Yoen; Oh, Yu Whan; Suh, Won Hyuck [College of Medicine, Korea University, Seoul (Korea, Republic of)

    2000-06-01

    To determine the utility of HRCT in the diagnosis of chronic airflow obstruction and to correlate the morphologic abnormalities revealed by this modality with functional impairment in patients with chronic airflow obstruction. This study involved 80 patients with chronic airflow obstruction who underwent HRCT and a pulmonary function test. Final clinical diagnosis in these patients was determined by a chest physician on the basis of clinical features, bronchoscopy, pulmonary function test, and HRCT. In order to diagnose and determine the extent of areas of decreased attenuation revealed by HRCT (the CT score), the findings of HRCT were retrospectively reviewed by two radiologists, who reached a consensus. Clinical and HRCT diagnoses were then compared, and the rate of agreement between them was calculated. The relationship between the extent of areas of decreased attenuation revealed by HRCT and by FEV1/FVC was evaluated using Correl's account and Student's unpaired t-test. The agreement rate between clinical and HRCT diagnoses was 77.5% (62/80). The rates for bronchiectasis (88.9%, 24/27), emphysema (93.9%, 31/33), and bronchiolitis obliterans (100%, 6/6) were considerably higher than those for chronic bronchitis and bronchial asthma. The correlation rate between CT score and FEV1/FVC was significant in bronchiectasis (p less than 0.05; r: -0.76) and bronchiolitis obliterans (p less than 0.01; r: -0.66), but not in cases involving emphysema, bronchial asthma, or chronic bronchitis (p greater than 0.05). HRCT is valuable in the diagnosis and prediction of physiologic impairment in patients with bronchiectasis and bronchiolitis obliterans, but has limited value in those with emphysema, chronic bronchitis or asthma. (author)

  13. Hierarchical organization versus self-organization

    OpenAIRE

    Busseniers, Evo

    2014-01-01

    In this paper we try to define the difference between hierarchical organization and self-organization. Organization is defined as a structure with a function. So we can define the difference between hierarchical organization and self-organization both on the structure as on the function. In the next two chapters these two definitions are given. For the structure we will use some existing definitions in graph theory, for the function we will use existing theory on (self-)organization. In the t...

  14. Regional ventilation/perfusion mismatch pattern in patient with Swyer James (MacLeod's) syndrome.

    Science.gov (United States)

    Sager, Sait; Asa, Sertac; Akyel, Reşit; Atahan, Ersan; Kanmaz, Bedii

    2014-09-01

    Swyer James (McLeod's) syndrome (SJMS) is an uncommon disease, which occurs as a result of childhood bronchiolitis obliterans. Patients may not be diagnosed until later in their life. A 46-year-old man underwent ventilation/perfusion scintigraphy for acute onset of dyspnea. The scan showed markedly diminished ventilation and perfusion unilaterally on the right middle and inferior lobes. However, mismatched ventilation-perfusion pattern was shown on the upper right lobe, which was consistent with pulmonary embolism. Unilaterally matched ventilation/perfusion defect can see in SJMS in lung scintigraphy; however, when pulmoner embolism may accompany, scintigraphy should be carefully examined. PMID:25535507

  15. 儿童闭塞性细支气管炎二例并文献复习

    Institute of Scientific and Technical Information of China (English)

    王晓敏; 赵津生

    2010-01-01

    @@ 闭塞性细支气管炎(bronchiolitis obliterans,BO)是儿科临床少见的以进行性呼吸困难及气流受阻为特点的慢性阻塞性疾病.自1901年Lange首次报道至今,关于其发病机制、治疗及预后等仍未明确.现将我院近年诊断的2例患儿报道如下.

  16. 慢性移植物抗宿主病的诊断和临床分级指南

    Institute of Scientific and Technical Information of China (English)

    李娅娜

    2006-01-01

    @@ 慢性移植物抗宿主病(graft-versus-host disease,GVHD)是异基因造血干细胞移植(hematopoietic cell transplantation,HCT)的主要并发症.其特征类似于自体免疫及其它免疫疾病的症状,如:硬皮病,S-综合征,原发胆汁性肝硬化,消耗病,闭塞性细支气管炎(bronchiolitis obliterans,BO),免疫性血细胞减少症,慢性免疫缺陷症.

  17. Downregulation of super oxide dismutase level in protein might be due to sulfur mustard induced toxicity in lung.

    OpenAIRE

    Leila Mirbagheri; Mehryar Habibi Roudkenar; Abbas Ali Imani Fooladi; Mostafa Ghanei; Mohammad Reza Nourani

    2013-01-01

    Sulfur mustard (SM) has been identified as an important chemical weapon. During the Iran-Iraq war of 1980-88, the extensive usage of SM against Iranian civilians and military forces was proven. This agent has been shown to cause severe damage mainly in the skin, eyes, lungs,  and  respiratory  tract  in  Iranian  veterans.  The  most  common  disease  is bronchiolitis obliterans (BO)). SM increases the endogenous production of reactive oxygen species (ROS). Superoxide dismutases (SODs) are kn...

  18. Pelvic Organ Prolapse

    Science.gov (United States)

    ... Procedures Implants and Prosthetics Urogynecologic Surgical Mesh Implants Pelvic Organ Prolapse (POP) Share Tweet Linkedin Pin it More sharing ... Treatment Options for Pelvic Organ Prolapse? What is Pelvic Organ Prolapse? Pelvic organ prolapse (POP) occurs when the tissue ...

  19. Organic plant breeding

    OpenAIRE

    Wolfe, Martin S.

    2002-01-01

    This report was presented at the UK Organic Research 2002 Conference. To a major extent, organic farming depends currently on plant and animal varieties that have been bred for non-organic farming and that are often not suited to organic production. This position is inconsistent with a holistic approach to organic agriculture. Organically-bred plant varieties are needed to develop both the potential of organic agriculture and its integrity. A first attempt at developing a concept for organic ...

  20. Interleukin 17 decrease the polarization of macrophage and attenuate the pathology of obliterative bronchiolitis after trachea transplant modulated%白细胞介素-17对巨噬细胞分化的影响及在闭塞性细支气管炎中的作用

    Institute of Scientific and Technical Information of China (English)

    王建刚; 周晓慧; 倪寅凯; 史乾; 曹浩; 范慧敏

    2012-01-01

    目的 探讨白细胞介素-17(IL-17)对巨噬细胞分化的影响,及其在小鼠闭塞性细支气管炎发展中的作用.方法 选取20 ~ 25 g清洁级雄性小鼠.C57BL/6,20只;IL-17基因敲除C57BL/6,10只;BALB/c,10只;按体质量随机配对分为3组.实验组A:BALB/c(5只)→C57 BL/6(10只);实验组B:BALB/c(5只)→IL-17基因敲除C57BL/6(10只);对照组:正常C57BL/6(10只)未手术组.于术后第7天检测脾脏中巨噬细胞的比例和CD80的表达水平,于第14天、28天取出移植气管分别进行病理形态学检测.结果 与对照组相比,实验组A巨噬细胞比例均显著增高;实验组B巨噬细胞比例相对于实验组A明显降低.第14天、28天实验组B的气管上皮损伤及纤维化程度相对于实验组A显著减轻.结论 IL-17基因敲除明显下调气管移植小鼠体内巨噬细胞表面CD80的表达水平,并明显减轻气管移植物的病理改变.%Objective To investigate the role of interleukin 17 in the differentiation of macrophages from monocyte in vivo and its applicability in Obliterative bronchiolitis (OB).Methods Pathogen-free male C57BL/6 (n =20),IL-17-defcient C57BL/6 (n =10) and BALB/c (n =10) weighing 20-25 g.Weight-matched mice were assigned to three experimental groups.Experimental group A:BALB/c (n =5) →C57 BL/6 (n =10).Experimental group B:BALB/c (n =5) →IL-17-defcient C57BL/6(n =10).Normal control group:C57BL/6(n =10).The CD80 expression in macrophages in spleens were analysed by flowcytometry 7 days after operation.Native and transplanted lungs were harvested after 14 days and 28 days,stained with HE,and examined under light microscopy.Results Compared to experimental group A,CD80 expression of macrophages reveales a significant decrease in spleen of experimental group B.Furthermore,airway obliteration and destruction of the epithelium in experimental group A were significantly better compared with that of experimental group B on day 14 and 28 after transplantation