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Sample records for bronchial asthma patients

  1. Assessment of Serum Vitamin D in Patients with Bronchial Asthma

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    Hisham E. Abd El Aaty

    2015-01-01

    Conclusions: Vitamin D deficiency was highly prevalent in asthmatic patients, there was a strong correlation between asthma severity and 25(OH vitamin D concentrations and there was a direct and a positive significant correlation between vitamin D levels and pulmonary function tests in asthmatic patients, so the measurement of serum vitamin D levels in patients with bronchial asthma is very useful.

  2. Sleep Disorders in Patients with Bronchial Asthma

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    Cukic, Vesna; Lovre, Vladimir; Dragisic, Dejan

    2011-01-01

    Respiratory disturbances during sleep are recognized as extremely common disorders with important clinical consequences. Breathing disorders during sleep can result in broad range of clinical manifestations, the most prevalent of which are unrefreshing sleep, daytime sleepiness and fatigue, and cognitive impairmant. There is also evidence that respiratory-related sleep disturbances can contribute to several common cardiovascular and metabolic disorders, including systemic hypertension, cardiac dysfunction, and insulin-resistance. Correlations are found between asthma-related symptoms and sleep disturbances. Difficulties inducing sleep, sleep fragmentation on polysomnography, early morning awakenings and daytime sleepiness are more common in asthmatics compared with subjects without asthma. The “morning deep” in asthma is relevant for the characterization of asthma severity, and impact drugs’ choices. Sleep and night control of asthma could be relevant to evaluate disease’s control. Appropriate asthma control recovering is guarantor for better sleep quality in these patients and less clinical consequences of respiratory disturbances during sleep. PMID:23678304

  3. Assessment of quality of life in bronchial asthma patients

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    N Nalina

    2015-01-01

    Full Text Available Introduction: Asthma is a common chronic disease that affects persons of all ages. People with asthma report impact on the physical, psychological and social domains of quality of life. Health-related quality of life (HRQoL measures have been developed to complement traditional health measures such as prevalence, mortality and hospitalization as indicators of the impact of disease. Objective and Study Design: The objective of this study was to assess HRQoL in Bronchial asthma patients and to relate the severity of asthma with their quality of life. About 85 asthma patients were evaluated for HRQoL and their pulmonary function tests values were correlated with HRQoL scores. Results and Conclusion: It was found that asthma patients had poor quality of life. There was greater impairment in quality of life in females, obese and middle age patients indicating that sex, body mass index and age are determinants of HRQoL in asthma patients.

  4. IMMUNOLOGICAL AND PSYCHOPHYSIOLOGICAL HETEROGENEITY AMONG PATIENTS WITH BRONCHIAL ASTHMA

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    A. V. Smyk

    2008-01-01

    Full Text Available Abstract. Bronchial asthma is a classic psychosomatic disease by immunopathological origin. In present investigation, we studied influence of body-oriented psychotherapeutic methods directed towards clinico-immunological parameters and special psychological features of the patients with bronchial asthma, i.e., decrease in alexithymia, as an important pathogenetic factor of bronchial asthma, and improvement in motor coordination and interhemispheric interactions in motor sphere. We investigated 38 patients (18 men and 20 women, while discriminating those patients who underwent a course of body-oriented psychotherapy, and a group of comparison, who did not undergo similar therapy. When observing conventional standards of randomization according to sex, age, clinical variants, and disease severity, some heterogeneity of these groups was revealed. In general, the people with active life attitude, being ready to work with a psychologist, possessed special features both in psychological and immunological spheres.

  5. Aeroallergen sensitivity among patients suffering from bronchial asthma in Bangalore

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    Giriyanna Gowda

    2013-01-01

    Full Text Available Background: Asthma is a serious public health problem throughout the world and its prevalence has increased in last 2-3 decades. Allergens are one of the many factors which trigger an attack of asthma. Skin prick test is useful in identifying the offending allergen in bronchial asthma. Aim: To identify the possible offending allergens in patients of bronchial asthma. Materials and Methods: The study was a descriptive study conducted at allergy center, Kempegowda Institute of Medical Sciences Hospital and Research Center, Bangalore from January to December 2011. Skin prick test was done in 139 patients suffering from bronchial asthma using 49 allergens extracts. Statistical Analysis: Frequency, proportions, Chi-square test, odds ratio, and 95% confidence interval was used. Results: Out of 139 patients who underwent the skin prick tests, 40% (56 were males and 60% (83 were females. Majority, that is, 60% were in the age group of 21-40 years. Forty-three percent (60 had family history of asthma/atopy, 80% (111 had allergic rhinitis, 24% (34 had chronic urticaria, and 24% (33 had allergic conjunctivitis. Out of 139 patients, 100 (71.94% were sensitive for one or more allergens. The common offending allergens found in the study were dust mites (Dermatophagoides farinae and D. pteronyssinus (DF and DP - 49.28%, dusts - 7.2%, pollens - 6.77%, insects - 6.62%, fungi - 4.53%, and epithelia - 1.92%. Conclusion: The most common allergens in bronchial asthma were dust mites followed by dusts and pollens. Identifying possible allergens in asthma patients help in allergen avoidance and immunotherapy in these patients.

  6. Temperament and stress coping styles in bronchial asthma patients

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    Kuna, Piotr; Witusik, Andrzej; Wujcik, Radosław; Antczak, Adam; Pietras, Tadeusz

    2016-01-01

    Introduction Temperament, defined as the formal characteristics of behavior, is a personality trait which can influence the clinical presentation and course of bronchial asthma. It determines susceptibility to stress as well as stress coping styles. Aim The aim of the study was to assess whether healthy subjects differ from bronchial asthma patients with regard to temperamental variables and stress coping styles, and whether these factors may also differentiate patients with severe asthma from those with the milder form. The study also assesses whether the results of flow volume curve analysis correlate with temperamental traits and stress coping styles. Material and methods The study was conducted in a group of 65 asthma patients and 62 healthy controls. All underwent flow volume curve examination and psychological tests: Formal Characteristics of Behavior – Temperament Inventory (FCB-TI) and Coping in Stress Situations (CISS) questionnaire. Results Bronchial asthma patients were characterized by a lower level of briskness (“agility”) than healthy subjects (13.35 ±4.48 vs. 14.97 ±3.98, p = 0.031). The remaining temperamental traits and stress coping styles did not differ between the groups. Additionally, the forced expiratory volume in 1 s (FEV1) value was found to correlate negatively with the intensity of the emotion-oriented stress coping style, whereas FEV1 and forced vital capacity (FVC) were found to positively correlate with briskness, emotional reactivity and endurance, while a negative correlation was found with activity. Conclusions Briskness differentiates healthy subjects from bronchial asthma patients. The values obtained in FEV1 and FVC pulmonary function tests were also found to correlate with some temperamental variables. PMID:28035226

  7. Reflexology and bronchial asthma

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    Brygge, T; Heinig, J H; Collins, P

    2001-01-01

    Many asthma patients seek alternative or adjunctive therapies. One such modality is reflexology, whereby finger pressure is applied to certain parts of the body. The aim of the study was to examine the popular claim that reflexology treatment benefits bronchial asthma. Ten weeks of active...

  8. Bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008049 Activation ralated genes of memory CD+4 T cells in asthma patients. PI Weifeng(皮卫峰),et al. Dept Respir Med, Xinhua Hosp, Sch Med, Shanghai Jiaotong Univ, Shanghai 200092. Chin J Tuberc Respir Dis 2007;30(12):932-935. Objective To screen and identify the genes of activated memory CD+4 T cells in asthma. Methods Differential display polymerase chain reaction(DDPCR) was utilized to identify genes of memory CD+4 T cells after activation from asthmatic patients and normal individuals,

  9. CT findings of the patients with bronchial asthma

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    Katagiri, Shiro; Ohshima, Kazuki [Chiba-Tokusyukai Hospital, Funabashi (Japan); Ohsawa, Takehiko

    1996-06-01

    CT scans were obtained in 45 patients with bronchial asthma including 23 patients during asthmatic attack. CT findings were as follows. (1) In all cases, thickening of bronchial wall throughout from central to peripheral bronchi and without tapering and/or slight swelling of bronchovascular bundles were observed. (2) Characteristics findings in 23 patients with asthmatic attack, lobular and multilobular high attenuation area were observed in 17 patients (74%) and nonhomogeneous attenuation in lung fields were noticed in 13 patients (57%). (3) Multiple centrilobular sized high attenuation area were observed in 23 patients, but it was difficult to differenciation whether these findings were due to tiny nodules or to small vessels. In conclusion, further studies are needed to know which pathomorphological and/or pathophysiological conditions are underlying these CT findings. (author)

  10. Benzalkonium Chloride Induced Bronchoconstriction in Patients with Stable Bronchial Asthma

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    Lee, Byoung Hoon

    2007-01-01

    Background Although benzalkonium chloride (BAC)-induced bronchoconstriction occurs in patients with bronchial asthma, BAC-containing nebulizer solutions are still being used in daily practice in Korea. The aim of this study was to evaluate the effects of inhaled aqueous solutions containing BAC. Methods Thirty subjects with bronchial asthma and 10 normal controls inhaled up to three 600 µg nebulized doses of BAC using a jet nebulizer. FEV1 (forced expiratory volume at one second) was measured 15 minutes after each dose. Inhalations were repeated every 20 minutes until FEV1 decreased by 15% or more (defined as BAC-induced bronchoconstriction) or the 3 doses were administered. Results The percent fall in FEV1 in response to BAC inhalation was significantly higher in asthmatics than in normal subjects (p<0.05). BAC administration in subjects with asthma reached a plateau (maximal effect). BAC-induced bronchoconstriction was found in 6 asthmatics (20%), with two responders after the 2nd inhalation and after the 3rd inhalation. The percent fall in FEV1 in response to the 1st inhalation of BAC was significantly higher in asthmatics with higher bronchial hyperresponsiveness (BHR) than in those with lower BHR. Conclusions This study suggests that the available multi-dose nebulized solution is generally safe. However, significant bronchoconstriction can occur at a relatively low BAC dose in asthmatics with severe airway responsiveness. PMID:18309682

  11. Symptoms, physical findings and bronchial hypersensitivity in patients with bronchial asthma and normal spirometry

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    Aćimović Slobodan

    2009-01-01

    Full Text Available Background/Aim. The diagnosis of bronchial asthma, a chronic inflammatory disease of the respiratory tract, is made on the basis of anamnesis, pathologic auscultatory findings of the lungs, lung function disturbances, skin tests, as well as the basic indices of immunologic condition in bronchial trunk. The aim of the study was to find out correlation of objective indices of the disease and than relation with the symptoms in the patients with bronchial asthma. Methods. The study included 60 young male non smokers with long lasting symptoms of bronchial asthma including shortness of breath, wheezing, hard breathing, nonproductive or productive cough, weakness and night hard breathing. There were no symptoms of respiratory infection over the past two months and lung radiography and spirometry were normal. Based on the results of nonspecific bronchoprovocative test two groups of the patients were formed, group I (n = 30 with positive histamine test (average value of the inhaled histamine concentration with FEV1 drop by 20% in regard with the initial value (PC20 = 2.99 ± 0.51 mg/ml of histamine and group II (n = 30 with negative histamine test (PC20(a = 14.58 ± 6.34 mg/ml of histamine. Results. The obtained spirometry results revealed a statistically significant difference in values of FEV1 between groups: I group - FEV1 = 93.2%; II group - FEV1 = 101.8%; (p < 0.05, Wilcoxon test, although all the FEV1 values were normal. Regarding the presence of the most common symptoms there was not statistically significant difference between the groups (p > 0. 05, chisquare test. Pathologic auscultatory lung findings were found in 73.4% of the patients in the group I and 27.5% of the patients in the group II. There was statistically significant difference (p < 0.05, chi-squared test. A positive correlation between the degree of hypersensitivity and lung physical findings was confirmed (p < 0.05 Spearman's rho, but there was no correlation with FEV1 values

  12. Preoperative Assessment of Different Treatment Modalities in Bronchial Asthma Patients

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    Kawther A. Azzam M.D. and **Sahar S. Khattab MD

    2003-06-01

    Full Text Available This study was performed to assess the effectiveness of acupuncture and medical therapies of bronchial asthma preoperatively. Sixty patients suffered from mild to moderate bronchial asthma and coming for elective operations were chozen from the outpatient clinic of Al-Zahraa University Hospital. Patients were randomly divided into three equal groups (n=20 each. Group I patients (drug group received oral theophylline and Salbutamol (ventolin inhaler according to the needs. Group II patients (drug +ear acupuncture group received same medical treatment as in group I and added ear acupuncture. Group III patients (drug + ear and body acupuncture group received same medical treatment as in group I and II and added ear and body acupuncture. Ventilatory function tests through spirometer and interleukin-13 estimation were performed before treatment and after two weeks of treatment. Improvement of subjective and objective parameters had occurred with significant decrease in the mean serum level of interleukin-13 and decrease in the mean number of using b-agonist puffs after two weeks of treatment in the three groups, with the best results being in group III than in group II and then in group I. Conclusion: Interleukin-13 estimation togheter with ventilatory function tests is a useful parameter for pre-operative assessment and evaluation of asthmatic patients. Also medication was significantly reduced when combined with acupuncture.

  13. Expression level of TGF-β1, U-Ⅱ in patients with bronchial asthma

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    Shang-Sun Cai; Guo-Ping Wu; Yuan-Zheng Yang; Ping Rao; Guang-Yu Wang; Qiong-Lian Huang

    2015-01-01

    Objective: To investigate the expression level in the serum of patients with bronchial asthma in TGF-β1, U-Ⅱ and their correlation. Methods: U-Ⅱ was measured by radioimmunoassay and TGF-β1 was measured by double antibody sandwich ELISA method in 45 patients with acute bronchial asthma, 43 cases of bronchial asthma in remission period and 41 healthy subjects. The correlation between TGF-β1 and U-Ⅱ was also analyzed. Results: There were significant differences in TGF-β1 and U-Ⅱ between healthy subjects and bronchial asthma patients (P<0.01), and the differences between patients at acute stage and remission stage was also significant (P<0.01). TGF-β1 was positively correlated with U-Ⅱ (P<0.05). Conclusions:TGF-β1 and U-Ⅱ are important indicators for treatment of bronchial asthma.

  14. Bronchial Thermoplasty in Asthma

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    Wayne Mitzner

    2006-01-01

    Full Text Available In this review we discuss the potential of a new procedure, termed Bronchial Thermoplasty to prevent serious consequences resulting from excessive airway narrowing. The most important factor in minimizing an asthmatic attack is limiting the degree of smooth muscle shortening. The premise that airway smooth muscle can be either inactivated or obliterated without any long-term alteration of other lung tissues, and that airway function will remain normal, albeit with reduced bronchoconstriction, has now been demonstrated in dogs, a subset of normal subjects, and mild asthmatics. Bronchial Thermoplasty may thus develop into a useful clinical procedure to effectively impair the ability for airway smooth muscle to reach the levels of pathologic narrowing that characterizes an asthma attack. It may also enable more successful treatment of asthma patients who are unresponsive to more conventional therapies. Whether this will remain stable for the lifetime of the patient still remains to be determined, but at the present time, there are no indications that the smooth muscle contractility will return. This successful preliminary experience showing that Bronchial Thermoplasty could be safely performed in patients with asthma has led to an ongoing clinical trial at a number of sites in Europe and North America designed to examine the effectiveness of this procedure in subjects with moderately severe asthma.

  15. [Treatment of patients with bronchial asthma associated with obesity in a health resort "Okeanskiy"].

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    Tsureva, U V; Demeev, Ya A; Skachkov, O A; Sheverdina, E A

    2015-06-01

    In this paper we assess the efficiency of sanatorium treatment of patients with bronchial asthma of two different weigh groups: with normal body weight and obesity. According to the results of clinical examination it was found that in patients with bronchial asthma and obesity of I-II degree efficiency of sanatorium treatment is lower in comparison with patients with bronchial asthma and normal body weight. The use of a standard set of procedures is not enough to correct the symptoms of asthma in obese patients. Comparative analysis of clinical symptoms in patients with bronchial asthma with normal body weight and obesity were differences of up to 50%. The conclusion about the need to develop a set of techniques to optimize the effectiveness of rehabilitation is given.

  16. Assessment of serum magnesium level in patients with bronchial asthma

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    Ahmad A. Ali

    2015-07-01

    Conclusion: Hypomagnesemia was found in patients with chronic stable asthma and also in those with acute asthma exacerbation compared to control. Serum mg levels were significantly lower in asthmatic patients during exacerbations compared with stable asthmatics.

  17. A study of the effect of yoga training on pulmonary functions in patients with bronchial asthma.

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    Sodhi, Candy; Singh, Sheena; Dandona, P K

    2009-01-01

    The role of yoga breathing exercises, as an adjunct treatment for bronchial asthma is well recognized. One hundred twenty patients of asthma were randomized into two groups i.e Group A (yoga training group) and Group B (control group). Each group included sixty patients. Pulmonary function tests were performed on all the patients at baseline, after 4 weeks and then after 8 weeks. Majority of the subjects in the two groups had mild disease (34 patients in Group A and 32 in Group B). Group A subjects showed a statistically significant increasing trend (P yoga breathing exercises used adjunctively with standard pharmacological treatment significantly improves pulmonary functions in patients with bronchial asthma.

  18. Bronchial thermoplasty : Long-term safety and effectiveness in patients with severe persistent asthma

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    Wechsler, Michael E.; Laviolette, Michel; Rubin, Adalberto S.; Fiterman, Jussara; Silva, Jose R. Lapa e; Shah, Pallav L.; Fiss, Elie; Olivenstein, Ronald; Thomson, Neil C.; Niven, Robert M.; Pavord, Ian D.; Simoff, Michael; Hales, Jeff B.; McEvoy, Charlene; Slebos, Dirk-Jan; Holmes, Mark; Phillips, Martin J.; Erzurum, Serpil C.; Hanania, Nicola A.; Sumino, Kaharu; Kraft, Monica; Cox, Gerard; Sterman, Daniel H.; Hogarth, Kyle; Kline, Joel N.; Mansur, Adel H.; Louie, Brian E.; Leeds, William M.; Barbers, Richard G.; Austin, John H. M.; Shargill, Narinder S.; Quiring, John; Armstrong, Brian; Castro, Mario

    2013-01-01

    Background: Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma. Objective: We sought to assess the effectiveness and safety of BT in asthmatic patients 5 years after therapy. Methods: BT-treated subjects from the A

  19. Features of application of medical physical culture for the children of patients by bronchial asthma.

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    Aleshina A.I.

    2012-07-01

    Full Text Available The purpose of work consists in generalization of scientific recommendations of scientists in relation to application of medical physical culture for children with bronchial asthma. The problem of bronchial asthma is analysed, as an enough widespread disease in the world, the basic tendencies of his prevalence, range of measures instrumental in diagnostics and treatment, are certain. It is presented statistical information about prevalence of bronchial asthma on Ukraine among children. Principal reasons of origin of disease and role of physical exercises in the process of rehabilitation of patients with bronchial asthma are certain. The features of the use and influencing of respiratory gymnastics on the method of Buteyko, Strel'nikovoy, drainage exercises, sound gymnastics, exercises of aerobic character are analysed. The necessity of application of medical physical culture at this disease is grounded.

  20. Rhinosinusitis predispose asthmatic patients to severe bronchial asthma.

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    Aazami, Ahad; Sharghi, Afshan; Ghofrani, Mohsen; Anari, Hassan; Habibzadeh, Elham

    2009-12-01

    In this study, we evaluated the relationship between rhinosinusitis to the severity of asthma in asthmatic patients.This cross-sectional study was conducted on 90 patients with asthma referring to Imam Khomeini Hospital in Ardabil city. Asthma control stepping method was used for staging of asthma severity. Patients' clinical signs and paraclinical findings were individually evaluated and compared with particular attention to the presence or absence of rhinosinusitis. Chi square and t-test were used to analyze the data in SPSS15 software.Rhinosinusitis was found in 66 (73%) of the 90 patients. The Forced Expiratory Volume in 1 second (FEV1) was significantly lower in the patients who also had rhinosinusitis (P=0.002).Comparing severity of asthma, most of the patients with rhinosinusitis were in stage3 (42.4%) but most of the patients without rhinosinusitis were in stage1 (41.6%) (p=0.002).The results of this study confirm the correlation between asthma severity and rhinosinusitis in asthmatic patients. Therefore, in diagnosing asthma in patients, the possibility of the rhinosinusitis should be determined and treated.

  1. Comparison of Glucocorticoid (Budesonide) and Antileukotriene (Montelukast) Effect in Patients with Bronchial Asthma Determined with Body Plethysmography

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    Lajqi, Njomza; Ilazi, Ali; Kastrati, Bashkim; Islami, Hilmi

    2015-01-01

    Objective: Effect of glucocorticoids-budesonide and antileukotriene–montelukast in patients with bronchial asthma and bronchial increased reactivity was studied in this work. Methods: Parameters of the lung function are determined with Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was also calculated. Results: Results of this research, in patients with bronchial asthma, indicate that glucocorticoids – budesonide (Pulmicort; 2 × 2 mg inh) has significant act...

  2. Alterations in circadian rhythms of melatonin and cortisol in patients with bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    Guang-he FEI; Rong-yu LIU; Zhi-hong ZHANG; Jiang-ning ZHOU

    2004-01-01

    AIM: To investigate the possible relationships between alterations in circadian rhythm of melatonin, cortisol and bronchial asthma. METHODS: Salivary melatonin and cortisol were measured simultaneously by radioimmunoassay in 10 mild intermittent or persistent patients, 11 moderate-to-severe persistent asthma patients, and 15 control subjects. Twelve salivary samples were collected in a series during a 24-h period in each subject. RESULTS: The results showed overall lower levels of salivary melatonin in asthma patients compared with control subject (P<0.01). The amplitude, peak-level, and baseline of salivary melatonin were significantly lower in mild intermittent or persistent (P<0.01, P<0.05) and moderate-to-severe persistent asthma patients (P<0.01) compared with control group. The 24-h mean level of salivary cortisol was greatly lower and the acrophase was markedly delayed in patients with mild intermittent or persistent asthma (P<0.01) and moderate-to-severe persistent asthma (P<0.05, P<0.01) compared with control subject. CONCLUSION: Disordered circadian rhythms of salivary melatonin and cortisol were found in asthma patients, which may be involved in the pathogenesis of bronchial asthma.

  3. [Epidural emphysema complicating bronchial asthma].

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    Rouetbi, N; Ben Saad, A; Joobeur, S; Skhiri, N; Cheikh Mhamed, S; Mribah, H; El Kamel, A

    2012-12-01

    Epidural emphysema is an exceptional complication of bronchial asthma, revealed by an incidental finding in chest tomography. We report a case of a 21-year-old man admitted with asthma attack complicated by subcutaneous and mediastinal emphysema. Chest tomography confirmed the mediastinal emphysema and also revealed the epidural emphysema within the vertebral canal. Neurological examination was negative. The patient showed complete recovery 10days after the onset of symptoms. The epidural emphysema is a rare complication during asthma attacks. The benignity of this complication should not require a systematic chest tomography.

  4. PHARMACOECONOMIC ASPECT OF OMALIZUMAB APPLICATION AMONG THE PATIENTS, SUFFERING FROM THE BRONCHIAL ASTHMA

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    A.S. Kolbin

    2008-01-01

    Full Text Available In the given article, the authors discuss the most difficult issue of the pediatrics, which is the treatment of the severe bronchial asthma. Our columnist is professor A.S. Kolbin introduces omalizumab, a new medication from the monoclonal antibodies group, to our readers. It allows practitioners to control the severe persistent bronchial asthma. The article accentuates the clinical effectiveness and pharmacoeconomic aspects of the medication application.Key words: bronchial asthma, severe run, treatment, monoclonal antibodies, children.

  5. [Pharmacotherapeutical management of bronchial asthma].

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    Leont'ev, S L; Mikhaĭlov, V G; Nevzorova, V P; Sadovnikova, R V; Shabashov, A F; Lugovkina, T K; Leshchenko, I V; Bel'tiukov, E K; Lebedeva, M K

    1998-01-01

    The analysis of the prescriptions for bronchial asthma (BA) patients in outpatient practice was made using data base created at the Regional Fund of Obligatory Health Insurance in the Sverdlovsk region with consideration of GINA principles of BA stepped care. The real structure of prescriptions was compared with the pattern drug official list for asthma care. The cost of each BA care step was calculated on the base of the computer programs. The analysis showed low quality of BA care in outpatient practice. The created computer programs are very useful for the prescriptions structure monitoring, cost-effect analysis and pharmacotherapeutical management of the diseases.

  6. Social networks and bronchial asthma.

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    D'Amato, Gennaro; Cecchi, Lorenzo; Liccardi, Gennaro; D'Amato, Maria; Stanghellini, Giovanni

    2013-02-01

    To focus on both positive and negative aspects of the interaction between asthmatic patients and the social networks, and to highlight the need of a psychological approach in some individuals to integrate pharmacological treatment is the purpose of review. There is evidence that in some asthmatic patients, the excessive use of social networks can induce depression and stress triggering bronchial obstruction, whereas in others their rational use can induce beneficial effects in terms of asthma management. The increasing asthma prevalence in developed countries seen at the end of last century has raised concern for the considerable burden of this disease on society as well as individuals. Bronchial asthma is a disease in which psychological implications play a role in increasing or in reducing the severity of bronchial obstruction. Internet and, in particular, social media are increasingly a part of daily life of both young and adult people, thus allowing virtual relationships with peers sharing similar interests and goals. Although social network users often disclose more about themselves online than they do in person, there might be a risk for adolescents and for sensitive individuals, who can be negatively influenced by an incorrect use. However, although some studies show an increased risk of depression, other observations suggest beneficial effects of social networks by enhancing communication, social connection and self-esteem.

  7. EXPRESSION OF SOCS3 AND SOCS5 MRNAS IN PERIPHERAL BLOOD MONONUCLEARS FROM THE PATIENTS WITH BRONCHIAL ASTHMA

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    V. V. Lim

    2014-01-01

    Full Text Available We observed sixty patients with allergic bronchial asthma (ABA and 54 with non-allergic bronchial asthma (NABA. Quantitative SOCS3 and SOCS5 mRNA expression was evaluated by means of real-time PCR. Eighteen healthy persons served as a control group. In patients with bronchial asthma (irrespectively of pathogenetic form, a significant increase of SOCS3 transcription factor expression was detected in peripheral blood mononuclears, as compared with control group. This increase was more pronounced in NABA group. The mRNA SOCS5 level was significantly decreased in bronchial asthma patients, as compared to control group, especially, in ABA subgroup rather than in NABA patients. Thus, an increased expression of SOCS3 mRNA in BA patients could be regarded as a protective antiinflammatory response Decrease of SOCS5 mRNA expression in patients with bronchial asthma (being more pronounced in ABA, may be indicative for a deficiency in negative feedback regulation of gene transcription in allergic bronchial asthma.

  8. CIRCADIAN ARTERIAL TENSION PROFILE IN THE PATIENTS WITH BRONCHIAL ASTHMA AND COMORBID HYPERTENSIVE DISEASE

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    T. N. Zaripova

    2016-01-01

    Full Text Available The aim of research is to study the state of circadian arterial tension profile in the patients with bronchial asthma and hypertensive disease as comorbid disease. Materials and methods. The research has been performed at 76 patients with bronchial asthma and hypertensive disease as comorbid disease (the main group and 52 patients with hypertensive disease as the comparison group. The groups were comparable with respect to the gender and age sign. Investigation was performed in the period of clinical remission. The main method used in this research was the investigation of day arterial tension profile in the time of its monitoring. Results. It has been revealed the presence of frequent and expressed change from the side of the studied indexes, especially in the patients with comorbid pathology, which were characterized by more frequent and more significant disorders from the side of diastolic blood pressure, especially at night in combination with more considerable and more rapid rise in early morning hours. The day arterial tension profile was characterized either with insufficient decline of arterial pressure at night or, opposite, with its sharp decrease. Specified disorders were increased as far as heaving of main and comorbid diseases, presence of disorders from the side of lipid exchange were not related to the phase of bronchial asthma (remission, exacerbation and level of its flow control. 

  9. EFFECTS OF INHALATED GLUCOCORTICOSTEROIDS TREATMENT ON CLINICAL AND EOSINOPHILIC INFLAMMATORY PARAMETERS IN PATIENTS WITH BRONCHIAL ASTHMA

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    Vladan Ćosić

    2010-03-01

    Full Text Available Inhaled glucocorticosteroids are the most efficient anti-inflamatory drugs used in asthma treatment that can bring the improvement of clinical symptoms as well as lung function. Eosinophils (Eo are the key efector cells in asthmatic inflammation, and determination of their number and concentration of mediators which can bring about eosinophilic activation- interleukin-5 (IL-5 would contribute to the evaluation of anti-inflammatory treatment effects in asthma patients.The aim of this study was to compare clinical parameters and eosinophilic inflammation parameters in patients with asthma, after 4-week treatment with fluticasone-propionate (FP in a daily dose of 500 μg.The study involved 39 patients with bronchial asthma as well as 17 healthy subjects (controls. Asthma symptom scores, FEV1, FEV1/FVC, total number of Eo in peripheral blood and IL-5 concentracion in serum were measured in all subjects, before and after FP 500 treatment. There was a significant decrease in asthma symptom scores (p<0.001 and improvement of FEV1 and FEV1/FVC (p<0.05 after FP 500 treatment.There was also a statistically significant negative correlation beetwen asthma symptom score and FEV1 before and after the treatment (r=-0,415, p<0,01; r=-0,346, p<0,05. The concentration of eosinophilic inflammatory parameters (Eo, IL-5 was significantly reduced after the treatment (p<0.05 in groups of patients with larger number of eosinophiles prior to the therapy.Besides lung function normalisation and improvement of disease symptoms after the treatment, there were higher concentrations of eosinophilic inflammatory parameters that point to persistant inflammation of airways during well-controlled asthma. It is necessary to constantly compare the symptoms of desease, lung function, severity of desease and level of inflammation parameters in order to assess the treatment effects of inhaled glycocortico-steroids.

  10. Application of the autoblood treated by preliminary extracorporeal X-ray irradiation in the therapy of bronchial asthma patients

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    Goguev, N.T.

    1985-02-01

    A therapeutic method including extracorporeal x-ray irradiation of the autoblood of patients with bronchial asthma complicated by cortisone dependence and polyvalent drug intolerance, has been elaborated and clinically tested. The use of this method brings about good short-term results in 90% of cases and good long-term results in 40% of cases (14-38 months). It provides an opportunity to give up corticosteroids in more than 60% of patients and to decrease the hormone dose in the rest of cortisone-dependent patients with bronchial asthma. The above therapeutic method can be used as an independent type of treatment, especially in the presence of polyvalent drug allergy and as an element of multiple modality therapy of bronchial asthma patients. The method was used under in-patient conditions only. No side effects were marked in the course of the clinical trial. To carry out this type of therapy, patients should be thoroughly screened.

  11. Observation on effect of acupuncture at Yuji(LU 10) on the pulmonary function of patients with bronchial asthma and immediate efficacy of relieving asthma

    Institute of Scientific and Technical Information of China (English)

    韩健

    2012-01-01

    Objective To observe the immediate efficacy difference of relieving asthma for patients with the acute attack of bronchial asthma between acupuncture and salbutamol and make the comparison of the efficacy at different time points during the needle retaining. Methods Five hundred and seventy-seven

  12. Chinese and Uighur medicine diagnostic criteria of the evaluation of the Modern drug treatment side-effects in bronchial asthma patients

    Institute of Scientific and Technical Information of China (English)

    Dubrovin Denis; Igor Gogol; Mikhail Baranov; Nurmuhammat Amat; Halmurat Upur

    2013-01-01

    We studied Chinese and Uighur medicines and create an automated computer diagnostics system according to principals of Uighur medicine for evaluation of bronchial asthma patient′s state. 498 patients with bronchial asthma were enrolled the automated computer diagnostic program. 304 patients were evaluated in the process of drug and non-drug treatment. Savda asthma type of Uighur medicine do not corresponds with any of the defined clinico-pathogenetic variants of the disease. Thus, prevailing of atopic bronchial asthma with probability of 0.7 is defined with Savda categories with deficiency' (P<0.01) variants in Chinese Medicine. The combination of infectious-dependent variant of bronchial asthma Abnormal Savda syndrome with Abnormal Savda syndrome bronchial asthma in 71% of cases have prevailing harder case of Abnormal Savda in 74% of cases belongs to the categories of an aspirin component in the pathogenesis of mixed asthma, in 83% of cases

  13. [Bronchial morphologic modification in asthma].

    Science.gov (United States)

    Cataldo, D; Louis, R; Godon, A; Munaut, C; Noël, A; Foidart, J M; Bartsch, P

    2000-07-01

    Asthma is an inflammatory disease of the airways clinically characterised by recurrent bronchial obstructions at least partially reversible. Recent epidemiologic data suggest that asthmatics have an increased rate of decrease of their expiratory volumes during life. This irreversible lung function impairment is associated with fundamental structural changes of the bronchial wall in terms of conjunctive tissue and smooth muscle composition. We describe these changes and explore the different mechanisms proposed to explain these structural modifications. We also review their consequences in terms of bronchial physiology and their potential influence on bronchial hyperresponsiveness.

  14. Emotional aspects of bronchial asthma in Indian patients: Evaluation of an interventional strategy

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    Behera D

    2006-01-01

    Full Text Available In order to improve the self care abilities of the patients with bronchial asthma a ′Self Care Manual′ (a Booklet of 26 pages on bronchial asthma was prepared. An interview schedule was developed to evaluate the usefulness of the manual. The validity and reliability of both these instruments were established. Five hundred and twenty three diagnosed patients of bronchial asthma (260 in the study group to whom the self care manual was given and 263 controls to whom no specific instructions were given were included in the study. Emotions like ′tension′, ′excessive laughter′, ′sadness′, ′happiness′ and ′anger′ etc. that triggered the symptoms were studied. The effect of self care manual on other emotions (FNx01a total of 8 items like ′anxiety due to the disease′, ′tension of taking medicine′ and ′fear of death′ etc. was also studied. Both groups were followed up at 2 weeks, 6 months and 1 year while the same interview schedule was administered on each visit. It was observed that the emotion scores decreased significantly in both the groups (8.08±5.5, 5.89±4.88, 1.44±4.63 and 1.19±4.01 in the study patients, whereas 8.50±6.30, 7.88±6.21, 7.35±6.03 and 5.97±5.81 in the controls at 0 weeks, 2 weeks, 6 months and 1 year respectively. The emotion scores were significantly less in the study group as compared to controls (unpaired ′t′ = 3.57, 8.52 and 7.67 at 2 weeks, 6 months and 1 year respectively (p< 0.001 Multiple logistic regression analysis showed that the odds ratio of study group patients showing significant improvement in emotion scores was 3.34 (95% CI, 1.78-6.25 and 4.26 (95% CI, 2.34-7.63 at 6 months and 1 year respectively as compared to controls. We concluded that patient education (self care manual in the form of a booklet made significant improvement in the emotions in patients with bronchial asthma.

  15. TRANSFORMING GROWTH FACTOR Β1 C-509T GENE POLYMORPHISM IN PATIENTS WITH BRONCHIAL ASTHMA

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    Milena Despotović

    2014-12-01

    Full Text Available Bronchial asthma is a poligenic disorder caused by the influence of genetic and envioromental factors. The functional single nucleotide polymorphism (SNPs in the regulatory regions of the cytokine genes may affect the cytokine production and thus play a contributory role in the pathogenesis of asthma. Substitution of cytosine (C by thymine (T at the position -509 in the promoter region of the transforming growth factor β1 (TGF-β1 gene could be associated with asthma. The aim of this study was to investigate the association of the TGF-β1 C-509T polymorphism with asthma and to determine the distribution of this polymorphism in the Serbian population. A total of 57 patients with diagnosed asthma and 49 healthy controls were screened for TGF-β1 C-509T polymorphisms using the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP method. The TGF-β1 C-509T genotype (p=0.413 and allele frequencies (p=0.227 distributions in patients did not reveal statistically significant difference compared to controls. Additionally, no difference in genotype and allele frequencies distribution between male and female subjects was observed. In conclusion, to the best knowledge of the authors, this is the first study examining the association of TGF-β1 C-509T polymorphism in the Serbian patients with asthma. The present study did not confirm the specific role of TGF-β1 C-509T polymorphisms in asthma. No differences in the distribution of TGF-β1 C-509T polymorphism between patients and healthy subjects were observed.

  16. EFFECT OF ACUPUNCTURE ON SERUM TNF-α ACTIVITY IN ALLERGIC BRONCHIAL ASTHMA PATIENTS

    Institute of Scientific and Technical Information of China (English)

    HUANG Tiejun; ZHANG Ji

    2002-01-01

    In this study, the therapeutic effect of acupuncture and its effect on serum tumor necrosis factor apha (TNF-α) level was observed in 25 cases of allergic bronchial asthma patients. Acupoints used were Dazhui (GV 14),Feishu (BL 13), Dingchuan (EX-B 1), Pishu (BL 20), Tanzhong (CV 17), Shenshu (BL 23) and Fengchi (GB 20),supplemented with other acupoints according to syndrome differentiation. After 15 sessions of treatment, results showed that the total effective rate was 96 %. Before treatment, serum TNF-α activity was significantly higher than that of healthy subjects (25 cases, P < 0.01 ). After treatment, TNF-α level reduced considerably in comparison with that of pre-treatment (P< 0.05). These findings indicate that acupuncture can significantly improve allergic asthma patients' clinical symptoms and lower serum TNF-α activity.

  17. Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study

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    L. Mastalerz

    2012-01-01

    Full Text Available Background. Special regulatory role of eicosanoids has been postulated in aspirin-induced asthma. Objective. To investigate effects of aspirin on exhaled breath condensate (EBC levels of eicosanoids in patients with asthma. Methods. We determined EBC eicosanoid concentrations using gas chromatography/mass spectrometry (GC-MS and high-performance liquid chromatography/mass spectrometry (HPLC-MS2 or both. Determinations were performed at baseline and following bronchial aspirin challenge, in two well-defined phenotypes of asthma: aspirin-sensitive and aspirin-tolerant patients. Results. Aspirin precipitated bronchial reactions in all aspirin-sensitive, but in none of aspirin-tolerant patients (ATAs. At baseline, eicosanoids profile did not differ between both asthma groups except for lipoxygenation products: 5- and 15-hydroxyeicosatetraenoic acid (5-, 15-HETE which were higher in aspirin-induced asthma (AIA than inaspirin-tolerant subjects. Following aspirin challenge the total levels of cysteinyl-leukotrienes (cys-LTs remained unchanged in both groups. The dose of aspirin had an effect on magnitude of the response of the exhaled cys-LTs and prostanoids levels only in AIA subjects. Conclusion. The high baseline eicosanoid profiling of lipoxygenation products 5- and 15-HETE in EBC makes it possible to detect alterations in aspirin-sensitive asthma. Cysteinyl-leukotrienes, and eoxins levels in EBC after bronchial aspirin administration in stable asthma patients cannot be used as a reliable diagnostic index for aspirin hypersensitivity.

  18. Phentolamine action in permeability of airways at patients with bronchial asthma.

    Science.gov (United States)

    Islami, Hilmi; Krasniqi, Shaip; Ahmetaj, Halil; Haliti, Naim; Kurtishi, Ilir; Ahmetaj, Salih; Ibrahimi, Ibrahim

    2011-01-01

    In this work, effect of phentolamine as antagonist of alpha-1 adrenergic receptor in patients with bronchial asthma and with obstructive chronic bronchitis was studied. Parameters of the lung function are determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines--Asthma with a possibility of aerosolization of 0.5 ml per minute. Results gained by this research shows that blockage of alpha-1 adrenergic receptor with phentolamine (10 mg by inhalator and intravenous ways and 20 mg by inhalator ways) has not changed significantly (p > 0.1) the bronchomotor tonus of tracheobronchial tree, by comparing it with the inhalation of natrium chloride solution with percentage of 0.9% (p > 0.1), or of hexoprenaline (2 inh x 0.2 mg) and atropine 1 mg/ml (p < 0.01). This suggests that the activity of alpha-1 adrenergic receptor in the smooth musculature is not a primary mechanism that causes reaction in patients with increased bronchial reactibility, in comparison to agonists of beta2--adrenergic receptor and cholinergic antagonists that expresses their significant action in reduction of specific resistance of airways.

  19. Tc-99m technegas scintigraphy to evaluate the lung ventilation in patients with oral corticosteroid-dependent bronchial asthma

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, Jiro; Okada, Hiroki; Momoi, Atsuko; Yamadori, Ichiro; Takahara, Jiro; Tanabe, Masatada [Kagawa Medical Univ., Miki (Japan); Takahashi, Kazue; Satoh, Katashi; Ohkawa, Motoomi

    1999-08-01

    Bronchial asthma is a clinical syndrome characterized by the reversibility of airway obstruction. Recently it has been suggested that remodeling of the airway causes irreversible airway obstruction which may be responsible for the patient's symptoms. With this background, the purpose of the present study was to assess patients with corticosteroid-dependent asthma by Tc-99m Technegas scintigraphy (Technegas) in both planar and SPECT images. Twelve patients (7 females and 5 males aged 36-72 years with a median age of 60 years: 4 smokers and 8 non-smokers) with oral corticosteroid-dependent asthma were enrolled in this study. Lung ventilation scanning with Technegas in both planar and SPECT images, high-resolution computed tomography, and pulmonary function tests were performed in all patients. The results of Technegas scanning were graded and correlations with other clinical parameters were evaluated. Significant abnormalities were detected by ventilation scintigraphy with Technegas in patients with corticosteroid-dependent bronchial asthma even during remission. Our data demonstrate that airflow obstruction took place in patients with corticosteroid-dependent asthma even during remission. Technegas scanning appears to be a useful radiopharmaceutical for demonstrating airflow obstruction in patients with bronchial asthma. (author)

  20. Morphologic aspects of airways of patients with pulmonary emphysema followed by bronchial asthma-like attack.

    Science.gov (United States)

    Haraguchi, M; Shimura, S; Shirato, K

    1996-02-01

    Morphometric analysis of airways was performed in autopsied lungs from four patients with pulmonary emphysema (PE) followed by bronchial-asthma (BA)-like attacks (Group PE+BA) (four males, 72 +/- 9 yr). The results were compared with those from five pulmonary emphysema patients (Group PE) (five males, age 71 +/- 4 hr), three patients with bronchial asthma (Group BA) (one female and two males, age 65 +/- 7 yr), and four control subjects with no pulmonary diseases (Group Cont) (one female, three males, age 64 +/- 4 yr). The proportion of gland area to bronchial wall (gland%), ratio of goblet-cell occupancy to the total epithelial layer (goblet%), thickness of the basement membrane, amount of intraluminal mucus (mucus occupying ratio; MOR%), and number of various cell types per square millimeter in airway walls in a section 4 microns thick were measured in central (3 to 8 mm diameter) and peripheral airways (2 mm or less diameter). Gland% for the PE+BA group was significantly greater than that for the Cont group, whereas it did not differ significantly from that of the PE or BA groups. Goblet% and thickness of the basement membrane in central and/or peripheral airways in Group PE+BA were significantly greater than those in Group Cont, whereas those in Group PE were similar to those in Group Cont. Although not statistically significant, MOR% in central and peripheral airways from Group PE+BA showed a similar value to that in Group BA, whereas MOR% in Group PE was the same as that in Group Cont. The eosinophil number in peripheral airways walls in Group PE+BA showed a similar value to that in Group BA, which was significantly greater than in Group Cont. Other cells (macrophages, lymphocytes, and neutrophils) showed similar values among Groups PE+BA, PE, and BA. The number of eosinophils in central and/or peripheral airways correlated significantly with both goblet% and BMT, whereas other cells did not. These findings indicate that the airways of Group PE+BA are

  1. Identifying Predictors of Response to Suplatast Tosilate among Patients with Moderate to Severe Bronchial Asthma Receiving Inhaled Steroid Therapy

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    Takemasa Nakagawa

    2005-01-01

    Conclusions: These results indicate that %EOS and %BASO are good candidates to predict the response to suplatast among patients with moderate to severe bronchial asthma on inhaled steroid therapy. These predictors may contribute, in combination with genomic information, to stratified medical treatment tailored to the individual needs of patients.

  2. Acute bronchial asthma

    Directory of Open Access Journals (Sweden)

    Susanna Ramuscello

    2007-04-01

    Full Text Available Asthma is one of the main causes of morbidity worldwide. It affects some 300 million individuals and has risen over the past 20 years, especially in the paediatric population. Asthma is a chronic inflammation of the airways, subject to periodic exacerbations, characterised by coughing and progressive dyspnoea. Clinical conditions may vary greatly, ranging from moderate exacerbation with an increase in nocturnal awakening and a less than 20% reduction in the flow peak, through to severe respiratory insufficiency that requires immediate intubation of the airways. Pharmacological treatment envisages a step approach that aims to obtain and maintain control over the symptoms, taking into consideration the effectiveness of the treatment available, potential side effects and cost. β2-agonists and corticosteroids are the drugs of election for both maintenance therapy and for treating exacerbations. Other therapeutic devices may prove useful in particular cases. One fundamental key point in treatment over time is the cooperation between patient and attending doctor. The latest review of the Global Initiative for Asthma (GINA guidelines was published in 2006.

  3. [Effects and significance of methacholine bronchial provocation tests and salbutamol bronchial dilation test on measurements of fractional exhaled nitric oxide in patients with asthma].

    Science.gov (United States)

    Liu, Jielu; Yu, Huapeng; Tan, Xiaomei; Wu, Shuhan; Zhang, Pan; Fang, Zekui; Wang, Cuilan; He, Xi

    2016-03-01

    To study the effects and significance of methacholine (Mch) bronchial provocation tests and salbutamol bronchial dilation test on measurements of fractional exhaled nitric oxide (FeNO) in patients with asthma. This was a prospective study conducted between November 2014 and August 2015. A total of 135 patients with asthma visiting the respiratory clinic of Zhujiang Hospital were enrolled. The patients received either Mch bronchial provocation test or salbutamol bronchial dilation test based on their FEV1/FVC values and cooperative degree. Mch bronchial provocation test was performed by using Astograph Jupiter-21 (Astograh group) or APS-Pro airway reaction testing apparatus (APS group), and salbutamol bronchial dilation test was performed by using Jaeger spirometer (Dilation group). We compared the differences between FeNO values measured before examinations (Pre-FeNO) and 5 min after completion of these examinations (Post-FeNO). The geometric mean of Pre-FeNO and Post-FeNO was 28.07 ppb and 24.08 ppb respectively in the Astograh group, with a significant decrease of the FeNO value after the examination (Z=-3.093, P=0.002). A significant difference between Pre-FeNO and Post-FeNO was found in patients who had positive provocation results in the Astograh group (Z=-2.787, P=0.005), but not in the patients with negative results (Z=-1.355, P=0.176). The geometric mean of FeNO in the APS group decreased significantly from 27.95 ppb to 23.15 ppb after the examination was completed (Z=-5.170, P=0.000); both in patients with positive saline or Mch provocation results and in patients with negative provocation results, the differences between Pre-FeNO and Post-FeNO in the APS group being significant (Z=-2.705, -3.709, -2.371, P=0.002, 0.000, 0.018). No difference of FeNO change(ΔFeNO) was observed between the 2 Mch bronchial provocation test groups (Uppb and that of Post-FeNO was 34.79 ppb in the Dilation group; the difference being not significant (Z=-1.281, P=0.200). Our

  4. A Patient with Bronchial Asthma in Whom Eosinophilic Bronchitis and Bronchiolitis Developed during Treatment

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    Yasutsugu Fukushima

    2010-01-01

    Full Text Available A 56-year-old woman was referred to our hospital because of dyspnea, wheezing, and a productive cough. Eight years before presentation, bronchial asthma was diagnosed and the patient received inhaled corticosteroids plus antiasthmatic agents (a long-acting inhaled p2-agonist, leukotriene modifiers, and theophylline. Chest radiography showed small diffuse nodular shadows, and a computed tomographic scan showed thickening of the bronchi and bronchioles, with diffuse centrilobular nodules in both lung fields. A blood test and microscopic examination of the bronchoalveolar fluid revealed marked eosinophilia. Transbronchial lung biopsy and transbronchial biopsy showed eosinophilic bronchitis and bronchiolitis. After treatment with oral prednisolone (40 mg daily and inhaled corticosteroids, the symptoms, blood eosinophilia, and radiographic findings improved. Recently, several similar cases of eosinophilic bronchiolitis have been reported. Studies of further cases and elucidation of the pathophysiology of eosinophilic bronchiolitis are necessary to establish a concept for this disease and to determine whether it should be classified as a subtype of bronchial asthma or as a distinct entity.

  5. Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report

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    Yildiz Levent

    2010-09-01

    Full Text Available Abstract Objective Strongyloides stercoralis is a soil-transmitted intestinal nematode that has been estimated to infect at least 60 million people, especially in tropical and subtropical regions. Strongyloides infection has been described in immunosupressed patients with lymphoma, rheumatoid arthritis, diabetes mellitus etc. Our case who has rheumatoid arthritis (RA and bronchial asthma was treated with low dose steroids and methotrexate. Methods A 68 year old woman has bronchial asthma for 55 years and also diagnosed RA 7 years ago. She received immunusupressive agents including methotrexate and steroids. On admission at hospital, she was on deflazacort 5 mg/day and methotrexate 15 mg/week. On her physical examination, she was afebrile, had rhonchi and mild epigastric tenderness. She had joint deformities at metacarpophalengeal joints and phalanges but no active arthritis finding. Results Oesophagogastroduodenoscopy was performed and it showed hemorrhagic focus at bulbus. Gastric biopsy obtained and showed evidence of S.Stercoralis infection. Stool and sputum parasitological examinations were also all positive for S.stercoralis larvae. Chest radiography result had no pathologic finding. Albendazole 400 mg/day was started for 23 days. After the ivermectin was retrieved, patient was treated with oral ivermectin 200 μg once a day for 3 days. On her outpatient control at 15th day, stool and sputum samples were all negative for parasites. Conclusion S.stercoralis may cause mortal diseases in patients. Immunosupression frequently causes disseminated infections. Many infected patients are completely asymptomatic. Although it is important to detect latent S. stercoralis infections before administering chemotherapy or before the onset of immunosuppression in patients at risk, a specific and sensitive diagnostic test is lacking. In immunosupressed patients, to detect S.stercoralis might help to have the patient survived and constitute the exact therapy.

  6. PSYCHOPHYSIOLOGIC AND IMMUNOLOGIC CHARACTERISTICS IN PATIENTS WITH BRONCHIAL ASTHMA AND HEALTHY MEN WITH DIFFERENT FUNCTIONAL ASYMMETRY OF BRAIN HEMISPHERES

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    T. Ya. Abramova

    2012-01-01

    Full Text Available Abstract. Possible interactions between psychophysiological and immunological parameters are documented in healthy persons and bronchial asthma patients, as based on our own data and other sources. A role of functional asymmetry of brain is regarded as a basic phenomenon determining main features of psychical activity, as well as functions of autonomous nervous system and immunological activity.

  7. A Case of Severe Bronchial Asthma Controlled with Tacrolimus

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    Hirokazu Taniguchi

    2011-01-01

    Full Text Available Background. The control of severe bronchial asthma, such as corticosteroid-resistant asthma, is difficult. It is also possible that immunosuppressive agents would be effective for bronchial asthma. Case Summary. A 55-year-old Japanese female presented with severe bronchial asthma controlled with tacrolimus. She had been diagnosed with bronchial asthma during childhood. Her asthma worsened, and a chest radiograph showed atelectasis of the left lung. Bronchoscopy revealed the left main bronchus to be obstructed with viscous sputum consisting of 82% neutrophils and no eosinophils. The atelectasis did not improve with corticosteroid treatment, but was ameliorated by administration of tacrolimus. Discussion. This patient had severe asthma due to neutrophilic inflammation of the airways. Tacrolimus is effective for treating severe asthma, for example, in corticosteroid-resistant cases.

  8. CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS

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    L. N. Sorokina

    2017-01-01

    Full Text Available Thirty-five patients with non-allergic bronchial asthma (NABA, 22 patients with NABA and diabetes mellitus type 2 (DT2, 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immunoassay kits purchased from VectorBest, and Cytokine. In asthma patients complicated by DT2, the pattern of bronchial asthma was ascribed to NABA. This finding may be consistent with a theory of specific insulin-receptor interactions in asthma. The NABA patients with type 2 diabetes mellitus exhibited a significant increase in IL-6, IFNγ, and decrease of IL-4, as compared with healthy controls and NABA. Moreover, we have revealed an increase of IL-4, IL-6, IFNγ, when compared with DT2. Hence, the patients with coexistence of non-allergic bronchial asthma and DT2 were characterized by a specific cytokine profile of pro- and anti-inflammatory cytokines, which may correlate with increased glycation and deterioration of lung function. 

  9. SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA

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    L. V. Ryabova

    2007-01-01

    Full Text Available Abstract. A study of leukocyte regulation system in patients with exacerbated bronchial asthma (BA was performed by means of measuring spontaneous and induced production of certain cytokines (IL-4, IL-1b, IL-10 and IFNg in whole blood, and drawing some specific coefficients reflecting production of the cytokines, as compared to control values. Group 1 consisted of mixed-type BA patients, with mild clinical manifestations at exacerbation stage. A control group included twelve healthy persons. The cytokine network was evaluated according to spontaneous production of cytokines (IL-4, IL-1b, IL-10 and IFNg, or their induction with standard mitogens (PHA and E. coli LPS. The results obtained have shown that in BA as a clinical model of chronic inflammation, synthesis and activation of the cytokines depend on the phase of disease. At stage of exacerbation, an imbalance occurs between pro- and anti-inflammatory cytokines, with predominance of anti-inflammatory IL-10, which is targeted to suppression of bronchial inflammation.

  10. Rates and predictors of uncontrolled bronchial asthma in elderly patients from western Romania

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    Marincu I

    2015-06-01

    Full Text Available Iosif Marincu,1 Stefan Frent,1 Mirela Cleopatra Tomescu,2 Stefan Mihaicuta1 1Department of Infectious Diseases, Pulmonology, Epidemiology and Parasitology, 2Department of Internal Medicine I, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania Purpose: Bronchial asthma (BA is a chronic inflammatory disorder of the airways, featuring variable and often reversible airflow limitations. An accurate assessment of BA control is difficult in practice, especially in the elderly, requiring the assessment of several clinical and paraclinical parameters that are influenced not only by asthma, but also by comorbidities. The purpose of this study was to evaluate the predictors of uncontrolled BA in a group of elderly patients from western Romania.Patients and methods: We retrospectively evaluated 126 elderly patients (aged ≥ 65 years, who were consecutively evaluated in the Pulmonology Department of Victor Babes Hospital, Timisoara, Romania, between March 2009 and July 2012. We collected demographic data, performed pulmonary function testing and an asthma control test (ACT, and evaluated the level of BA control based on the 2012 Global Initiative for Asthma guidelines. Statistical processing of the data was done using the Epi Info and STATA programs.Results: In our study group, 36 (29% patients were men and 90 (71% were women; their mean age was 74.42±8.32 years (range: 65–85 years. A total of 14.28% of patients were smokers. About 30.15% of patients had an ACT score <19, 54.76% had an ACT score 20–24, and 15.09% had an ACT of 25. Moreover, 59.52% had normal spirometry results. Infectious exacerbations were found in 58.73% of patients. A history of allergies was demonstrated in 48.41% of patients, 34.12% had occupational exposure, and 82.53% of patients were treated with inhaled corticosteroids. Our results showed that 30.15% of patients had uncontrolled BA. We found six predictive factors for uncontrolled BA: infectious exacerbation

  11. CYTOKINE PROFILE AND ADHESION MOLECULES IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG DISEASE COMBINED WITH BRONCHIAL ASTHMA

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    T. G. Shapovalova

    2010-01-01

    Full Text Available The study involved 56 patients with chronic obstructive pulmonary disease (COPD, stage III-IV, 38 patients with severe bronchial asthma (BA, and 45 patients with a combination of COPD stage III-IV and bronchial asthma at exacerbation period. In all the patients, we have measured blood levels of pro-inflammatory (IL-6, IL -8, TNFα and anti-inflammatory (IL-4 cytokines, amounts of cell adhesion molecules (ICAM- 1, VCAM-1, along with assessment of contractile myocardial functional disorders by means of Doppler echocardiography. Highest rates of pro-inflammatory cytokines and adhesion molecules were found in the group of patients with combined pathology, along with most significant signs of myocardial hypertrophy, both in right and left heart compartments, accompanied by a decrease in contractile myocardial function.

  12. Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema.

    Science.gov (United States)

    Kanazawa, H; Kurihara, N; Otsuka, T; Fujii, T; Tanaka, S; Kudoh, S; Hirata, K; Takeda, T

    1996-01-01

    Interleukin-8 (IL-8) belongs to the family of chemotactic cytokines and has been shown to activate neutrophils in vitro and in vivo. In this study, we measured IL-8 concentration in the serum of patients with pulmonary emphysema or bronchial asthma. IL-8 concentration in serum of emphysema patients was significantly higher than in asthmatics; in emphysema patients it was significantly correlated with the smoking index and the annual decrease of FEV1.0. In asthmatics IL-8 concentration was below the level of detection, but was markedly increased during exacerbation of asthma. Our findings suggest that IL-8 may be one of the causal factors in these diseases.

  13. Do Panic Symptoms Affect the Quality of Life and Add to the Disability in Patients with Bronchial Asthma?

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    A. D. Faye

    2015-01-01

    Full Text Available Background. Anxiety and panic are known to be associated with bronchial asthma with variety of impact on clinical presentation, treatment outcome, comorbidities, quality of life, and functional disability in patients with asthma. This study aims to explore the pattern of panic symptoms, prevalence and severity of panic disorder (PD, quality of life, and disability in them. Methods. Sixty consecutive patients of bronchial asthma were interviewed using semistructured proforma, Panic and Agoraphobia scale, WHO Quality of life (QOL BREF scale, and WHO disability schedule II (WHODAS II. Results. Though 60% of the participants had panic symptoms, only 46.7% had diagnosable panic attacks according to DSM IV TR diagnostic criteria and 33.3% had PD. Most common symptoms were “sensations of shortness of breath or smothering,” “feeling of choking,” and “fear of dying” found in 83.3% of the participants. 73.3% of the participants had poor quality of life which was most impaired in physical and environmental domains. 55% of the participants had disability score more than a mean (18.1. Conclusion. One-third of the participants had panic disorder with significant effect on physical and environmental domains of quality of life. Patients with more severe PD and bronchial asthma had more disability.

  14. Imaging diagnosis of bronchial asthma and related diseases

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, Fumikazu; Fujimura, Mikihiko; Kimura, Fumiko; Fujimura, Kaori; Hayano, Toshio; Nishii, Noriko; Machida, Haruhiko; Toda, Jo; Saito, Naoko [Tokyo Women' s Medical Coll. (Japan)

    2002-12-01

    We describe imaging features of bronchial asthma and related diseases. The practical roles of imaging diagnosis are the evaluation of severity and complications of bronchial asthma and differential diagnosis of diseases showing asthmatic symptoms other than bronchial asthma. (author)

  15. Bronchial gland duct ectasia in fatal bronchial asthma: association with interstitial emphysema.

    OpenAIRE

    Cluroe, A.; Holloway, L.; Thomson, K.; Purdie, G; Beasley, R.

    1989-01-01

    To determine the incidence of bronchial gland duct ectasia in fatal asthma and its association with interstitial emphysema, the histological features of 72 patients in whom death was considered to be due to asthma, and 72 matched control subjects in whom sudden death was not attributed to asthma, were reviewed. In all cases and controls, sections of two or more blocks of lung tissue stained with haematoxylin and eosin were obtained at necropsy. Bronchial gland duct ectasia was diagnosed if th...

  16. The effect of various breathing exercises (pranayama in patients with bronchial asthma of mild to moderate severity

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    Saxena Tarun

    2009-01-01

    Full Text Available Background/Aim: The incidence of bronchial asthma is on increase. Chemotherapy is helpful during early course of the disease, but later on morbidity and mortality increases. The efficacy of yoga therapy though appreciated is yet to be defined and modified. Aim: To study the effect of breathing exercises ( pranayama in patients with bronchial asthma of mild to moderate severity. Materials and Methods: Fifty cases of bronchial asthma (Forced Expiratory Volume in one second (FEV1 > 70% were studied for 12 weeks. Patients were allocated to two groups: group A and group B (control group. Patients in group A were treated with breathing exercises (deep breathing, Brahmari , and Omkara , etc. for 20 minutes twice daily for a period of 12 weeks. Patients were trained to perform Omkara at high pitch (forceful with prolonged exhalation as compared to normal Omkara . Group B was treated with meditation for 20 minutes twice daily for a period of 12 weeks. Subjective assessment, FEV1%, and Peak Expiratory Flow Rate (PEFR were done in each case initially and after 12 weeks. Results: After 12 weeks, group A subjects had significant improvement in symptoms, FEV1, and PEFR as compared to group B subjects. Conclusion: Breathing exercises ( pranayama , mainly expiratory exercises, improved lung function subjectively and objectively and should be regular part of therapy.

  17. LOCAL AND SYSTEMIC IMMUNE MECHANISMS OF CHRONIC INFLAMMATION IN THE PATIENTS WITH MILD BRONCHIAL ASTHMA

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    L. V. Ryabova

    2009-01-01

    Full Text Available Abstract. A study of leukocyte regulation system in a remission stage of bronchial asthma (BA patients included following tests: CD-typing of lymphocytes, investigations in humoral and phagocytic mechanisms of immunity, evaluation of bronchoalveolar lavage characteristics, measurements of spontaneous production of IL-4, IL-1β, IL-10 and IFNγ cytokines in whole blood supernates and bronchoalveolar lavage, as compared with control samples. The first group represented mild-stage, mixed-type BA patients (both allergy- and infection-dependent, being in remission state. The second (control group consisted of sixteen conditionally healthy patients.The results have shown that, even at early stages of BA development, some components of chronic inflammatory process are formed. They could be characterized as accumulation of different inflammatory cells, i.e., eosinophils, neutrophils, alveolar macrophages and monocytes at the local level. In parallel, some changes in T-, B-subpopulations and phagocytic compartment occur at systemic level. All these events comprise a basis for changes in type and quantity of the cytokines produced. It was established that the profile of cytokine secretion in peripheral blood is identical to the cytokine secretion profile in lung tissue.

  18. [The clinical importance of determining fibronectin and the activity of proteolysis inhibitors in patients with bronchial asthma complicated by pulmonary emphysema].

    Science.gov (United States)

    Okopnaia, L M; Glazatova, T M; Zorin, V N; Vassim, K; Padalka, I M

    1995-01-01

    Examinations of 27 inpatients with infection-dependent bronchial asthma complicated by pulmonary emphysema revealed low levels of fibronectin and alpha proteinase inhibitor, which were in a positive correlation. The said deficiency was stable in asthmatics and was virtually unchanged as remission was attained. Hence, we may propose that the said changes may underlie not only the development, but stabilization and progress of pulmonary emphysema in patients with the infection-dependent variant of bronchial asthma.

  19. PATHOGENETIC JUSTIFICATION AND EFFICIENCY OF MELATONIN APPLICATION IN PATIENTS WITH BRONCHIAL ASTHMA

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    G. I. Litvinenko

    2012-01-01

    Full Text Available Abstract. Present study dealt with efficiency of melatonin implementation in a combination therapeutic schedule of bronchial asthma (BA. A group of 248 patients with atopic, or mixed clinical forms of BA being in exacerbation, or medication remission state, and 36 healthy donors were included into the study. Melatonin (Melaxen, Unifarm, USA was administered as a single daily dose of 0.003 g, at 21.00, accompanied by a standard therapy in twenty BA patients for 21 days. We determined contents and functional properties of Т- and B-lymphocytes, mononuclear phagocytes, IgE, IL-4, IFNγ levels, as well as melatonin concentrations in blood serum in the morning and evening time. When included into BA treatment protocol, melatonin proved to cause partial restoration of circadian rhythm for Tand B cell subpopulations, mononuclear phagocytes, cytokine production, due to its chronotropic and immunomodulating activity. This effect is associated with a more pronounced clinical effect, thus presuming reversibility of desynchronosis state.

  20. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930904 A clinical study on determination ofplasma vasoactive intestinal peptide and its rela-tionship with bronchial responsiveness in asth-matics.LIU Ao(刘翱),et al.Dept Respir Med,Kunming General Hosp,Kunming Command,Kunming,650032.Chin J Intern Med 1993;32(3):165-166.Vasoactive intestinal peptide(VIP),which islocalized in normal human lung,may play an im-portant role in regulating bronchial tone,pul-monary blood flow and mucus secretion.Thelevel of plasma VIP and bronchial responsivenesswere studied in patients with asthma,and chronicbronchitis and in the healthy subjects.The re-sults showed that the level of plasma VIP in

  1. [Delayed asthma bronchiale due to epoxy resin].

    Science.gov (United States)

    Authried, Georg; Al-Asadi, Haifaa; Møller, Ulla; Sherson, David Lee

    2013-10-28

    Epoxy resin is a low molecular weight agent, which can cause both acute and delayed allergic reactions. However, it is known causing skin reactions with direct or airborne contact. Rarely it can cause airway reactions like asthma bronchiale. We describe a case of a windmill worker who developed delayed asthma bronchiale due to airborne contact with epoxy resin.

  2. INVESTIGATION OF IMMUNE STATUS AND PRODUCTION CYTOKINE IN THE PATIENTS WITH ATOPIC AND MIXED-TYPE BRONCHIAL ASTHMA

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    A. V. Zurochka

    2009-01-01

    Full Text Available Abstract. We have performed immunophenotyping of lymphocytes, employing a flow cytometry approach, along with evaluation of spontaneous or mitogen-induced production of cytokines (IFNγ, IL-4, IL-1β, IL - 10, in the patients with atopic and bacterial (mixed-type bronchial asthma. We have detected mostly similar changes in lymphocyte parameters. However, among the patients with bacterial asthma, an imbalance of immune cells was more pronounced. Some common alterations of cytokine production were found, i.e., a decrease in IFNγ and IL-1β production, along with increased IL-4 and IL-10. These changes were more significant in the subjects being in acute phase of either atopic, or bacterial asthma. Moreover, IL-10 suppressed IFNγ to higher degree, than IL-4, thus favoring distinct predomination of Th2-type immune response.

  3. Comparison of Glucocorticoid (Budesonide) and Antileukotriene (Montelukast) Effect in Patients with Bronchial Asthma Determined with Body Plethysmography

    Science.gov (United States)

    Lajqi, Njomza; Ilazi, Ali; Kastrati, Bashkim; Islami, Hilmi

    2015-01-01

    Objective: Effect of glucocorticoids-budesonide and antileukotriene–montelukast in patients with bronchial asthma and bronchial increased reactivity was studied in this work. Methods: Parameters of the lung function are determined with Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was also calculated. Results: Results of this research, in patients with bronchial asthma, indicate that glucocorticoids – budesonide (Pulmicort; 2 × 2 mg inh) has significant action (p< 0.01) on reduction of the specific resistance (SRaw) of airways, applied to the same patients 3 days after administration of montelukast, at home (2 × 10 mg). Three days after administration of the montelukast, antileukotriene medicine, at home, on the fourth day same patients administered a capsule of montelukast, 10 mg dose per os, and significantly (p < 0.05) reduced the increased bronchomotor tonus; and the effect of the control with salbutamol (beta2-adrenergic agonist) is effective in removal of the increased bronchomotor tonus, causing significant decrease of the resistance (Raw), respectively of the specific resistance (SRaw), (p < 0, 01). Conclusion: This suggests that the bronchodilator effect of glucocorticoids is more powerful than of the leukotriene, because glucocorticoids terminate the early stage of chemical mediator release (prostaglandins PgD2, SRS, and leukotriene LTC4, LTD4, LTE4 and Cytokinins also etc.) as powerful bronchoconstriction substances, whilst antileukotriene substances does not have this feature. PMID:26862243

  4. The level of emotional intelligence for patients with bronchial asthma and a group psychotherapy plan in 7 steps.

    Science.gov (United States)

    Ropoteanu, Andreea-Corina

    2011-01-01

    Strong emotions, either positive or negative, as well as vulnerability to stress are often major factors in triggering, maintaining and emphasizing the symptoms of bronchial asthma. On a group of 99 patients suffering from moderately and severely persistent allergic bronchial asthma for more than 2 years, I applied a situational test of emotional intelligence, the NEO PI-R personality test provided by D&D Consultants and I also elaborated a psychosocial test form of asthma by which I evaluated the frequency of physical symptoms, the intensity of negative emotional symptoms arisen during or subsequent to the crisis and the level of the patients' quality of life. I have presumed first that if the level of the emotional intelligence grew, this fact would have a significant positive influence on controlling the negative emotional symptoms arisen during or subsequent to the crisis and on patients' quality of life. This was invalidated, the correlations between the mentioned variables being insignificant. Secondly, I have presumed the existence of positive significant correlations between the emotional intelligence coefficient and the personality dimensions: extraversion, openness, conscientiousness and a negative significant correlation between the emotional intelligence coefficient and the dimension neuroticism. This presumption was totally confirmed. Finally, we proposed a group psychotherapy plan in 7 steps for asthmatic patients that has as main objectives to improve symptoms and therefore the patients' quality of life.

  5. Lung sound analysis helps localize airway inflammation in patients with bronchial asthma

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    Shimoda T

    2017-03-01

    Full Text Available Terufumi Shimoda,1 Yasushi Obase,2 Yukio Nagasaka,3 Hiroshi Nakano,1 Akiko Ishimatsu,1 Reiko Kishikawa,1 Tomoaki Iwanaga1 1Clinical Research Center, Fukuoka National Hospital, Fukuoka, 2Second Department of Internal Medicine, School of Medicine, Nagasaki University, Nagasaki, 3Kyoto Respiratory Center, Otowa Hospital, Kyoto, Japan Purpose: Airway inflammation can be detected by lung sound analysis (LSA at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma. Patients and methods: Breath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL, expiration sound pressure level (ESPL, and the expiration-to-inspiration sound pressure ratio (E/I were calculated in 6 frequency bands. The data were analyzed for potential correlation with spirometry, airway hyperresponsiveness (PC20, and fractional exhaled nitric oxide (FeNO. Results: The E/I data in the frequency range of 100–400 Hz (E/I low frequency [LF], E/I mid frequency [MF] were better correlated with the spirometry, PC20, and FeNO values than were the ISPL or ESPL data. The left anterior chest and left posterior lower recording positions were associated with the best correlations (forced expiratory volume in 1 second/forced vital capacity: r=–0.55 and r=–0.58; logPC20: r=–0.46 and r=–0.45; and FeNO: r=0.42 and r=0.46, respectively. The majority of asthmatic subjects with FeNO ≥70 ppb exhibited high E/I MF levels in all lung fields (excluding the trachea and V50%pred <80%, suggesting inflammation throughout the airway. Asthmatic subjects with FeNO <70 ppb showed high or low E/I MF levels depending on the recording position, indicating uneven airway inflammation. Conclusion: E/I LF and E/I MF are more useful LSA parameters for evaluating airway inflammation in bronchial asthma; 7-point lung

  6. REGULATION OF IMMUNE RESPONSE OF PATIENTS WITH PARTIALLY CONTROLLED vs CONTROLLED BRONCHIAL ASTHMA

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    E. Yu. Barabash

    2017-01-01

    Full Text Available A control group included seventeen conditionally healthy people (Group 1. Eighty-eight patients with proven bronchial asthma (BA at the age of 22 to 48 were enrolled into the study. I.e., Group 2 included nine patients with well-controlled BA. Group 3 included persons with partially controlled BA (n=79. There were 8 people with easily treated BA in group 2, and 57 such cases in Group 3. The levels of interleukins (IL-4, IL-10, IL-17A, interferon-γ (IFNγ, and tumor-α necrosis factor (TNFα were monitored by means of flow cytometry technique. The parameters of cellular immunity were registered by flow cytofluorimetry assays. Phagocytosis indicators were studied by means of D. Mayansky method, metabolic activity of neutrophils, by the B.Park method, as modified by E.Shmelev. Evaluation of cellular immunity did not reveal statistically significant differences for distinct CD subpopulations between healthy controls and BA patients. The patients with controlled and partially controlled BA exhibited some changes in cytokine concentrations, i.e., increased IL-4, IL-17А, IL-10 and TNFα levels; changes in phagocytosis and oxygen dependent bactericidal activities of neutrophils. We have revealed higher concentrations of IL-4, IL-17А in the less controlled BA (group 3 , as compared with group 2. TNFα induction remained at significantly higher level in both groups of BA patients, exceeding mean control values by 2.3 times. The degree of IL-10 production in group 2 with controlled BA was significantly higher than in group with partial disease control (group 3, p < 0.001, thus suggesting application of IL-10 levels as an index of active inflammation control. Patients with BA (groups 2, 3 exhibited a decrease of basal IFNγ, as compared to healthy people (p < 0.001. In group 3 (partial control, this parameter was 3-fold lower than in healthy persons. Evaluation of monocyte/phagocyte functions showed statistically significant differences between BA

  7. Radioaerosol Inhalation Imaging in Bronchial Asthma

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    Kim, Bum Soo; Park, Young Ha; Park, Jeong Mi; Chung, Myung Hee; Chung, Soo Kyo; Shinn, Kyung Sub; Bahk, Yong Whee [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1991-03-15

    Radioaerosol inhalation imaging (RII) has been used in radionuclide pulmonary studies for the past 20 years. The method is well accepted for assessing regional ventilation because of its usefulness, easy fabrication and simple application system. To evaluate its clinical utility in the study of impaired regional ventilation in bronchial asthma, we obtained and analysed RIIs in 31 patients (16 women and 15 men; age ranging 21-76 years) with typical bronchial asthma at the Department of Radiology, Kangnam St. Mary's Hospital, Catholic University Medical college, from January, 1988 to August, 1989. Scintiscans were obtained with radioaerosol produced by a HARC(Bhabha Atomic Research Center, India) nebulizer with 15 mCi of {sup 99m}Tc-phytate. The scanning was performed in anterior, posterior and lateral projections following 5-minute inhalation of radioaerosol on sitting position. The scans were analysed and correlated with the results of pulmonary function study and the findings of chest radiography. Fifteen patients had concomitant lung perfusion image with {sup 99m}Tc-MAA. Follow-up scans were obtained in 5 patients after bronchodilator therapy. 1 he patients were divided into (1) attack type (4 patients), (2) resistant type (5 patients), (3) remittent type (10 patients) and (4) bronchitic type (12 patients). Chest radiography showed hyperinflation, altered pulmonary vascularity, thickening of the bronchial wall and accentuation of hasal interstitial markings in 26 of the 31 patients. Chest radiographs were normal in the remaining 5 patients. Regardless of type, the findings of RII were basically the same, and characterized by the deposition of radioaerosol in the central parts or in the main respiratory air ways along with mottled nonsegmental ventilation defects in the periphery. Peripheral parenchymal defects were more extensive than that of expected findings from clinical symptoms, pulmonary function test and chest radiograph. Broomstick sign was present

  8. Virus Infection-Induced Bronchial Asthma Exacerbation

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    Mutsuo Yamaya

    2012-01-01

    Full Text Available Infection with respiratory viruses, including rhinoviruses, influenza virus, and respiratory syncytial virus, exacerbates asthma, which is associated with processes such as airway inflammation, airway hyperresponsiveness, and mucus hypersecretion. In patients with viral infections and with infection-induced asthma exacerbation, inflammatory mediators and substances, including interleukins (ILs, leukotrienes and histamine, have been identified in the airway secretions, serum, plasma, and urine. Viral infections induce an accumulation of inflammatory cells in the airway mucosa and submucosa, including neutrophils, lymphocytes and eosinophils. Viral infections also enhance the production of inflammatory mediators and substances in airway epithelial cells, mast cells, and other inflammatory cells, such as IL-1, IL-6, IL-8, GM-CSF, RANTES, histamine, and intercellular adhesion molecule-1. Viral infections affect the barrier function of the airway epithelial cells and vascular endothelial cells. Recent reports have demonstrated augmented viral production mediated by an impaired interferon response in the airway epithelial cells of asthma patients. Several drugs used for the treatment of bronchial asthma reduce viral and pro-inflammatory cytokine release from airway epithelial cells infected with viruses. Here, I review the literature on the pathogenesis of the viral infection-induced exacerbation of asthma and on the modulation of viral infection-induced airway inflammation.

  9. Parameters of activity of local and systemic inflammation in patients with bronchial asthma women without exacerbation of the disease

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    A. V. Barkova

    2016-01-01

    Full Text Available The study was conducted to evaluate the activity parameters of local and systemic inflammation in women suffering from bronchial asthma (BA. 119 women with asthma were studied, and 48 with a regular menstrual cycle and 71 in menopause; 38,7% of BA was mild, 61,3% – moderate severity. All patients were examined in the remission phase of the disease. On the background of normal values of conventional indicators of inflammation it was showed a significant increase of IL 1 alpha and IL 8 more in the group of women with regular menstrual cycles and normal body weight, IL1 alpha amounted to 489±80 pg/ml and IL8 – 631±122 pg/ml (p<0.05, which emphasizes the role of hormonal status of patients, and also the necessity of using the basic anti-inflammatory therapy during remission of BA.

  10. Lung Sounds in Bronchial Asthma

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    Yukio Nagasaka

    2012-01-01

    In lung sound analysis, the narrower the airways are, the higher the frequency of breathing sounds is, and, if a patient has higher than normal breathing sounds, i.e., bronchial sounds, he or she may have airway narrowing or airway inflammation. It is sometimes difficult to detect subtle changes in lung sounds; therefore, we anticipate that automated analysis of lung sounds will be used to overcome these difficulties in the near future.

  11. Chinese and Uighur medicine diagnostic criteria of the evaluation of the Modern drug treatment side-effects in bronchial asthma patients

    Institute of Scientific and Technical Information of China (English)

    Dubrovin Denis; Igor Gogol; Mikhail Baranov; Nurmuhammat Amat; Halmurat Upur

    2014-01-01

    We studied Chinese and Uighur medicines and create an automated computer diagnostics system according to principals of Uighur medicine for evaluation of bronchial asthma patient′s state .498 patients with bronchial asthma were enrolled the automated computer diagnostic program .304 patients were evalu‐ated in the process of drug and non‐drug treatment .Savda asthma type of Uighur medicine do not corre‐sponds with any of the defined clinico‐pathogenetic variants of the disease .Thus ,prevailing of atopic bron‐chial asthma with probability of 0 .7 is defined with Savda categories with such as ‘Lungs energy deficien‐cy’ ,‘Spleen energy deficiency’ and ‘Kidneys Yin deficiency’ (P <0 .01) variants in Chinese Medicine . The combination of infectious‐dependent variant of bronchial asthma Abnormal Savda syndrome with atopy with a probability of 0 .8 is accompanied by the categories of ‘Hot and Full’ asthma with such variants as‘Lungs energy deficiency’ ‘Spleen energy deficiency’ ,‘Kidneys Yin deficiency’ (P < 0 .01) .Patients with an easier case of Abnormal Savda syndrome bronchial asthma in 71% of cases have prevailing diagnos‐tic categories of ‘External ,Full and Cold’ asthma .Patients with a harder case of Abnormal Savda in 74%of cases belongs to the categories of ‘Internal ,Empty and Hot’ asthma .So ,hormone dependency of the disease in 69% of cases is accompanied by the ‘Kidneys Yin deficiency’ variant and ,if there is an aspirin component in the pathogenesis of mixed asthma ,in 83% of cases ‘Kidneys Yin deficiency’ and ‘Kidneys Yang deficiency’ variants are defined .

  12. Influence of Natural Lung Surfactant Inhalations on Clinical Symptoms and Pulmonary Function Parameters in Patients with Bronchial Asthma. Communication 1

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    O.V. Stepanova

    2016-12-01

    Full Text Available Background: Damage to lung surfactant (LS enabling the lung local immunity may contribute to the development of bronchial inflammation in patients with bronchial asthma. Methods and Results: A 40-day course of 16 LS (Surfactant-BL inhalations at the dose of 25mg was added to inhaled corticosteroids (ICS and short/long-acting bronchodilators or combined inhalers in 14 patients with bronchial asthma. After 7 inhalations, patients demonstrated a significant decrease in shortness of breath and bronchospasm attacks, double reduction of ICS dose (p=0.01, and improvement of pulmonary function. Forced vital capacity (FVC increases during treatment in a linear fashion (y=62.9+5.60•x; p<0.05, reaching the normal level (80% after 9 inhalations (Day 15. Forced expiratory volume (FEV1 increases in a linear fashion (y=50.7+4.15•x; p<0.05 without reaching the normal level (80% after 16 inhalations (Day 41. The FEV1/FVC ratio does not change significantly in the time period between Day 1 to Day 15. By Day 41 the value decreases significantly to 67.4±4.66% (p<0.05. The peak expiratory flow (PEF parameter increases in a linear fashion (y=53.9+5.00•x; p<0.01 from 57.7±6.33% to 76.2±9.33% of the predicted value. Conclusion: LS inhalations improve the condition of patients with BA, allow ICS dose reduction by 2 times, and improve pulmonary function parameters.

  13. Justification of advisability of using physical factors in the treatment of patients with allergic rhinitis and associated bronchial asthma

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    T. N. Zaripova

    2012-01-01

    Full Text Available The efficiency of treatment of patients with allergic rhinitis and associated bronchial asthma by physical factors and advisability of two-stage treatment are justified. Sixty six patients were observed. The conclusion on the efficiency of treatment was based on the data about the dynamics clinical state of the primary and associated diseases, intensity of inflammation activity in respiratory tract (rhinocytograms, biochemical indices of nasal lavages, level of nitrogen oxide in expired air were studied, patency of airways (manometry, spirography. We compared two versions of treatment: two- and one-stage. Patients of the first group (30 patients received elimination therapy for 3 to 5 days with the following peaty mud application, current of supersonic frequency, massage, inhalations, physical therapy. Patients of the second group (36 patients did not receive elimination therapy. We have found a decrease in intensity of clinical implications of the primary and associated diseases, decrease in inflammation activity, better nasal and bronchial носовой patency, improvement of the mucociliary function in patients of the first group. In the second group, the recovery of the surface epithelium and nasal patency was not observed against the background of improvement of the clinical state.

  14. Features of Atopic Reactivity in Schoolchildren with Severe Bronchial Asthma

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    U.I. Marusyk

    2014-12-01

    Full Text Available The study involved 30 students with severe bronchial asthma and 30 children with moderate to severe course. Patients with severe bronchial asthma revealed a clear tendency to increase the relative content of interleukin 4 in peripheral blood, which indirectly indicates the severity of inflammation in the bronchi. Almost every second child suffering from severe bronchial asthma reported an increase in the concentration of immunoglobulin E (more than 545.3 IU/ml, and the odds ratio was 1.9 (95% CI 1.1–3.4. In the group of patients with severe bronchial asthma, cases of increased skin sensitivity to household allergens were significantly more frequent compared to the second group. Thus, the size of hyperemia over 15.0 mm was recorded in 81.5 % of children of the first group and only in 51.9 % of persons (Pϕ < 0.05 in the second one. Clinical and epidemiological risk and diagnostic value of individual indicators of atopic reactivity were determined to verify the phenotype of severe bronchial asthma.

  15. Effect of Ligustrazine Injection on Levels of Interleukin-4 and Interferon-γ in Patients with Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective:To explore the effect of ligustrazine injection (LI) on serum levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) in patients with bronchial asthma and determine the mechanism of action of LI in preventing and treating asthma.Methods:Sixty-eight patients with mild or moderate bronchial asthma were assigned to two groups equally according to their sequence number,odd or even.The conventional treatment was administered to both groups,and LI was given to the treatment group by ultrasonic spray inhalation twice a day but not to the control group.The therapeutic course for all was 2 weeks.Further,30 healthy subjects who had no history of smoking were enrolled as the normal control group.The clinical condition scores,frequency of attacks and dosage of Terbutaline inhaled were scored and recorded on the first day of hospitalization (before treatment) and after treatment.At the same time,the indexes of lung function,including forced expiratory volume in one second (FEV1),forced expiratory volume in one second to forced vital capacity ratio (FEV1%) and the peak expiratory flow (PEF) were determined before treatment.The levels of IL-4 and IFN-γ in peripheral blood were detected by ELISA before and after treatment,and compared with that of the healthy control group.]Results:After treatment,the clinical condition scores were found to be lower,indexes of lung function were elevated,but serum level of IL-4 and ratio of IL-4/IFN-γ were reduced in both groups,showing significant differences as compared to those before treatment (P<0.05).However,the changes in all the indexes were more significant in the treatment group than in the control group,also showing statistical significance (P<0.05).No significant difference was revealed when IFN-γ levels were compared before and after treatment in both groups,though a lowering trend could be seen,significant difference could not be found in the comparison of IFN- γ levels between groups after treatment (P>0

  16. [Bronchial asthma pathogenesis and genetic prognosis development].

    Science.gov (United States)

    Balmasova, I P; Sepiashvili, R I; Sepiashvili, Ia R; Malova, E S

    2014-01-01

    The review is dedicated to an actual problem--genetic prognosis of risk of bronchial asthma development that is quite a complex aspect of studies from a methodological viewpoint. Bronchial asthma--heterogeneous disease by both etiology and clinical characteristics. At the same time genetic prognosis is based on the unity of pathogenetic mechanisms of development, though in immunological reactions that are the base of this disease, alternative variants are possible. The aim of this review is carrying out parallels between modern achievements in the field of deciphering trigger mechanisms of bronchial asthma pathogenesis and object of genetic studies based on these mechanisms. Among the examined conceptions--role of epithelial tissue in trigger mechanisms of bronchial asthma, variants of key role of immune system cells, first of all, T-helpers of various types for further development of inflammatory-effector reactions with damage characteristic for this disease. Compliance of contemporary approaches of genetic studies and novel concepts of bronchial asthma pathogenesis is shown.

  17. Hemodynamics features and contractive miocardial function in patients with chronical obstructive pulmоnаry diseases accompanied by bronchial asthma

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    T.G. Shapovalova

    2010-03-01

    Full Text Available Hemodynamics and contractive myocardial function features in patients with chronic obstructive pulmonary disease (OOPD accompanied by bronchial asthma have been examined. The changes of cardiohemodynamics have been presented according to the ventilation disorders level, balance of blood cytokines (IL-4, IL-6, IL-8, TFN-a and adhesion molecules level (IOAM-1, VOAM-1

  18. Environmental risk factors and allergic bronchial asthma.

    Science.gov (United States)

    D'Amato, G; Liccardi, G; D'Amato, M; Holgate, S

    2005-09-01

    The prevalence of allergic respiratory diseases such as bronchial asthma has increased in recent years, especially in industrialized countries. A change in the genetic predisposition is an unlikely cause of the increase in allergic diseases because genetic changes in a population require several generations. Consequently, this increase may be explained by changes in environmental factors, including indoor and outdoor air pollution. Over the past two decades, there has been increasing interest in studies of air pollution and its effects on human health. Although the role played by outdoor pollutants in allergic sensitization of the airways has yet to be clarified, a body of evidence suggests that urbanization, with its high levels of vehicle emissions, and a westernized lifestyle are linked to the rising frequency of respiratory allergic diseases observed in most industrialized countries, and there is considerable evidence that asthmatic persons are at increased risk of developing asthma exacerbations with exposure to ozone, nitrogen dioxide, sulphur dioxide and inhalable particulate matter. However, it is not easy to evaluate the impact of air pollution on the timing of asthma exacerbations and on the prevalence of asthma in general. As concentrations of airborne allergens and air pollutants are frequently increased contemporaneously, an enhanced IgE-mediated response to aeroallergens and enhanced airway inflammation could account for the increasing frequency of allergic respiratory allergy and bronchial asthma. Pollinosis is frequently used to study the interrelationship between air pollution and respiratory allergy. Climatic factors (temperature, wind speed, humidity, thunderstorms, etc) can affect both components (biological and chemical) of this interaction. By attaching to the surface of pollen grains and of plant-derived particles of paucimicronic size, pollutants could modify not only the morphology of these antigen-carrying agents but also their allergenic

  19. Association and symptom characteristics of irritable bowel syndrome among bronchial asthma patients in Kuwait

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    Panicker Radhakrishna

    2010-01-01

    Full Text Available Context : Excess prevalence of irritable bowel syndrome in asthma has been reported, suggesting a link between these two conditions. Aims: To investigate the association between irritable bowel syndrome (IBS and asthma, and explore the symptoms of IBS among asthma patients in Kuwait. Settings and Design: Case control study. Methods: In a tertiary center, for allergy and asthma, 138 patients aged 20-65 years, with asthma, diagnosed clinically and by spirometry,were compared with 145 healthy, non-asthmatic controls matched for age, gender and nationality. Cases and controls completed a self-administered questionnaire of irritable bowel syndrome diagnosis (ROME II criteria. Statistical Analysis Used: The data were analyzed using SPSS software, and proportions were tested with Chi-square or Fisher′s test. Odds ratio (OR with 95% Confidence Interval (CI were calculated to identify the associated risk factors. The demographic variables were selected for logistic regression analysis. Results : A significantly large proportion (39.13% of asthmatics had IBS as compared to 7.93% controls (P < 0.001. A higher proportion of females with IBS were observed in cases and controls (74%, 61.54%. IBS was seen in 87% cases using inhalers, and in 13% with additional oral theophylline (P < 0.001. As many as 66.6% cases, had IBS with relatively short duration of asthma (1-5 years, P < 000. Predominant symptoms of IBS in asthmatics were abdominal discomfort or distension (64.8% vs. 11.5%, (P < 0.000, OR = 14.1; 95%CI: 3.748-53.209, bloated feeling of abdomen (74.1% vs. 34.62% (P < 0.001, OR = 5.38; 95%CI:1.96-14.84, increased frequency of stools (63%, P < 0.006. Conclusions: Irritable bowel syndrome in asthmatics was significantly high, more in the female asthmatics. Abdominal discomfort, persistent bloated feeling, increased frequency of passing stools were the most common IBS symptoms observed.

  20. Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: Relationship of local responsiveness to cytokine production by peripheral blood mononuclear cells

    Directory of Open Access Journals (Sweden)

    Keiji Maeda

    1998-01-01

    Full Text Available To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i bronchial asthma patients with serum house dust mite (HDM-specific IgE antibody; (ii allergic rhinitis patients with serum HDM-specific IgE antibody; (iii normal control subjects with HDM-specific IgE antibody; and (iv normal control subjects without IgE antibody specific for 10 common aero-allergens. Bronchial hyperresponsiveness was detected in all subjects with asthma (group 1 and in some subjects from groups 2 and 3, but not in subjects from group 4. Nasal hyperresponsiveness was found in all subjects with allergic rhinitis (group 2 and in some subjects from groups 1 and 3, but not in subjects from group 4. These findings indicate that local hyperresponsiveness of the non-diseased organ is influenced by an individual's atopic status. Interleukin (IL-4 and IL-5 production by peripheral blood mononuclear cells (PBMC was measured after stimulation with HDM in groups 1, 2 and 3 and was found to be similar in all three groups. A correlation between bronchial hyperresponsiveness and in vitro cytokine production was noted in asthma patients. These results suggest that the capacity of IL-4 or IL-5 production by PBMC may reflect local hyperresponsiveness in case of asthma.

  1. Study of Therapeutic Mechanism of Acupuncture in Treating Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    LI; Ji

    2001-01-01

    It has been considered by modern medicine that bronchial asthma is a chronic airway allergic inflammation (AAI) which is the major factor that induces reversible airway ventilating disturbance and bronchial hyper-responsiveness (BHR) in asthmatic patients, as well as a correlation between the delayed-phase onset of asthma and AAI is more significant than immediate-phase onset of asthma in its pathogenesis. Anti-inflammatory therapy as a fundamental principle of treatment for bronchial asthma has been brought forward during the interval phase so that a large number of anti-AAI drugs to significantly enhance the curative effect such as inhalant corticoid, disodium cromoglycate, and leukotriene receptors antagonist, etc., has been rapidly developed. Additionally, traditional Chinese medicine (TCM) and integration of TCM and western medicine (WM) therapies, including acupuncture, are gradually taken into account by the medical circle as a characteristic in our country for treatment of bronchial asthma. It is worthy of being pointed out that the curative effect of acupuncture and moxibustion in treating asthma is evident, and that its therapeutic mechanism has to a certain extent, been found along with the recent deep-going acupunctural research.……

  2. Study of Therapeutic Mechanism of Acupuncture in Treating Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@  It has been considered by modern medicine that bronchial asthma is a chronic airway allergic inflammation (AAI) which is the major factor that induces reversible airway ventilating disturbance and bronchial hyper-responsiveness (BHR) in asthmatic patients, as well as a correlation between the delayed-phase onset of asthma and AAI is more significant than immediate-phase onset of asthma in its pathogenesis. Anti-inflammatory therapy as a fundamental principle of treatment for bronchial asthma has been brought forward during the interval phase so that a large number of anti-AAI drugs to significantly enhance the curative effect such as inhalant corticoid, disodium cromoglycate, and leukotriene receptors antagonist, etc., has been rapidly developed. Additionally, traditional Chinese medicine (TCM) and integration of TCM and western medicine (WM) therapies, including acupuncture, are gradually taken into account by the medical circle as a characteristic in our country for treatment of bronchial asthma. It is worthy of being pointed out that the curative effect of acupuncture and moxibustion in treating asthma is evident, and that its therapeutic mechanism has to a certain extent, been found along with the recent deep-going acupunctural research.

  3. Remission of bronchial asthma after viral clearance in chronic hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Norihiko Yamamoto; Kazumoto Murata; Takeshi Nakano

    2005-01-01

    A 53-year-old man with a history of blood transfusion at the age of 20 was admitted to our hospital because of liver dysfunction. He had bronchial asthma when he was 18 years old, which naturally resolved within 2 years. However, his bronchial asthma recurred at the age of 45 and was treated with oral theophylline. He was diagnosed as having chronic hepatitis C based on the histological and clinical findings, and then interferon (IFN) therapy was administered. The frequency of bronchial asthma attack was gradually decreasing after IFN therapy with marked improvement of hypereosinophilia. He achieved sustained viral response (SVR) and his bronchial asthma did not worsen even after the cessation of IFN. Hepatitis C virus (HCV) infection and IFN therapy were considered in the remission of asthma in this case. HCV infection could be the cause of bronchial asthma, especially in patients with late appearance of asthma.

  4. Relationship between flow volume curve and CT findings in non-smoking patients with long histories of bronchial asthma

    Energy Technology Data Exchange (ETDEWEB)

    Kawamoto, Hitoshi; Kambe, Masayuki; Yamagata, Mitsunori; Nakajima, Hidekatsu [Hiroshima Univ. (Japan). School of Medicine; Yamane, Kousuke; Kuraoka, Toshihiko; Miyamura, Isao

    2001-08-01

    This study was conducted to verify whether bronchial asthma (BA) alone causes pulmonary emphysema (PE), and to examine the computed tomography (CT) findings in non-smokers with BA demonstrating the flow volume curve (FV curve) characteristic of PE. Non-smoking patients with a history of BA for more than 20 years were divided into 2 groups: the dogleg pattern group (n=5), with an FV curve characteristic of PE, and the concave pattern group (n=16) with an FV curve characteristic of BA. CT scans was performed using CT values (level, 900 H.U.; width, 400 H.U.) that facilitate detection of a low attenuation area (LAA), and using conventional CT values (level, 700 H.U.; width, 1,300 H.U.). LAA (including air trapping), thickness of the bronchial wall, and partial atelectasis were compared between the 2 groups. PE was not detected, although air trapping was found in all subjects. The thickness of the airway was greater in the dogleg pattern than in the concave pattern. The incidences of air trapping and partial atelectasis were higher in the former than in the latter. BA alone may not cause PE. Some BA patients without PE show the FV curve characteristic of PE, reflecting an increase in the thickness of the airway wall and a decrease in the pulmonary ventilation probably due to the air trapping and the partial atelectasis. (author)

  5. ETIOLOGICAL STRUCTURE OF VIRAL RESPIRATORY DISEASES IN ADULT PATIENTS WITH BRONCHIAL ASTHMA EXACERBATION AND CHRONICAL BRONCHIOLITIS OBLITERANS

    Directory of Open Access Journals (Sweden)

    V. Z. Krivitskaya

    2015-01-01

    Full Text Available Exacerbation of bronchial asthma (BA and common deterioration of health during chronic bronchiolitis obliterans (ChBO are associated with viral infections in adults in 64 and 83% respectively. Mixed virus-viral associations were shown in 21–25% of cases. Respiratory syncytial infections were diagnosed with the highest frequency (50% in patients with BA. Influenza A(H1N1pdm09 and adenoviral infections dominated in persons with ChBO in 50 and 42% of cases, respectively. Response of virus-specific IgG in patients with BA and ChBO indicates the acute course of influenza A(H1N1pdm09 (63% of seroconversions. There were no reactions of IgG which is specific to respiratory syncytial virus in 75% of cases and to adenovirus in 83% of cases, that is the risk factor for occurrence of latent/persistent infection. Presence of structural components of respiratory syncytial virus in the upper respiratory tract had been revealed in three patients with asthma within at least 21–28 days. Respiratory syncytial viral infections and pandemic influenza A(H1N1 pdm09 in patients with BA and ChBO are characterized by the presence of an allergic component, which is indicated by the high levels of virus-specific IgE in blood. An adenoviral infection, in contrast, has no such peculiarity. 

  6. Randomized controlled study of CBT in bronchial asthma

    Directory of Open Access Journals (Sweden)

    Grover Naveen

    2007-01-01

    Full Text Available The aim of the present study was to find out efficacy of cognitive behavior therapy, as an adjunct to standard pharmacotherapy, in bronchial asthma. In a random-ized two-group design with pre-and post assessments, forty asthma patients were randomly allotted to two groups: self management group and cognitive behavior therapy group. Both groups were exposed to 6-8 weeks of intervention, asthma self management program and cognitive behavior therapy. Assessment measures used were-Semi structured interview schedule, Asthma Symptom Checklist, Asthma di-ary, Asthma Bother Profile, Hospital Anxiety & Depression Scale, AQLQ and Peak Expiratory Flow Rate. Within group comparison showed significant improvement in both groups at the post assessment. Between group comparisons showed that CBT group reported significantly greater change than that of SM group. Cognitive behavior therapy helps in improving the managment of asthma.

  7. IMMUNOLOGICAL MARKERS OF UNCONTROLLED ATOPIC BRONCHIAL ASTHMA IN CHILDREN

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    M. V. Smolnikova

    2017-01-01

    Full Text Available Bronchial asthma is a prevalent chronic allergic disease of lungs at early ages. A priority  task in allergology  is to search  biological  markers  related  to uncontrolled atopic  bronchial asthma. Cytokines fulfill their distinct function in pathogenesis of atopic  bronchial asthma, participating at the initiation, development and persistence of allergic inflammation in airways, causing different  variations of clinical course of the disease (with  respect  to its acuteness, severity, frequency of exacerbations. The  present  work has studied  indices  of cellular  and  humoral links of immunity, as well as levels of some  pro and  anti-inflammatory cytokines in peripheral blood serum (IL-4, IL-10, IL-2 and TNFα, aiming to determine potential markers of uncontrolled atopic bronchial asthma in children. A group of Caucasian (European children was involved into the research: Cohort 1, moderate atopic  bronchial asthma with controlled course during the last 3 months (n = 59; Cohort 2, severe/moderate-severe atopic bronchial asthma with uncontrolled course of the disease within last 3 months (n = 51,  Cohort 3 – control, practically healthy  children without signs of atopy  (n = 33. All the  children included in the group with atopic  bronchial asthma underwent regular mono/combined basic therapy  at high/ intermediate therapeutic doses.  We performed a comparative analysis  of cell  population indices  reflecting certain cellular  immunity links,  and  determined significantly  lower  levels of CD3+   lymphocytes, as well as decrease in relative  and  absolute  contents of CD4+  and  CD8+  cells in the  cohort with  uncontrolled course of atopic  bronchial asthma, as compared with controlled-course cohort. When  evaluating concentrations  of cytokines in peripheral blood serum of the patients with controlled and uncontrolled atopic  bronchial asthma, we revealed  significantly  higher

  8. Typhoid fever as a triggering factor in acute and intractable bronchial asthma attack.

    Science.gov (United States)

    Wardhana; Surachmanto, Eko E; Datau, E A

    2013-10-01

    Typhoid fever is an enteric infection caused by Salmonella typhi. In Indonesia, typhoid fever is endemic with high incidence of the disease. In daily practice we frequently have patients with bronchial asthma, and it is becoming worse when these patients get typhoid fever. After oral ingestion, Salmonella typhi invades the the intestine mucosa after conducted by microbial binding to epithelial cells, destroying the microfold cells (M cell) then passed through the lamina propria and detected by dendritic cells (DC) which express a variety of pathogen recognition receptors on the surfaces, including Toll-Like Receptor (TLR). expressed on macrophages and on intestinal epithelial cells inducing degradation of IB, and translocation of NF-B (Nuclear Factor-Kappa Beta). This process initiates the induction of pro-inflammatory gene expression profile adhesion molecules, chemokines, adhesion molecules, and other proteins that induce and perpetuate the inflammation in host cells then will induce acute ant intractable attack of bronchial asthma. The role of typhoid fever in bronchial asthma, especially in persons with acute attack of bronchial asthma, is not well understood. In this article, we will discuss the role of typhoid fever in the bronchial asthma patients which may cause bronchial asthma significantly become more severe even triggering the acute and intractable attack of bronchial asthma. This fact makes an important point, to treat completely the typhoid fever in patients with bronchial asthma.

  9. Pranlukast hydrate in the treatment of pediatric bronchial asthma

    Directory of Open Access Journals (Sweden)

    Yoshihara S

    2013-07-01

    Full Text Available Shigemi Yoshihara Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan Abstract: Pranlukast hydrate is a potent, selective, orally active, cysteinyl leukotriene antagonist that binds at the type 1 receptor. It is used as a 10% dry syrup to treat asthma and allergic rhinitis in pediatric patients. In a 4-week, dose-finding study, a dose-dependent improvement in lung function was observed in pediatric patients with asthma at an optimal dose of 5.1–10 mg/kg/day. In a comparative, randomized, double-blind, 4-week multicenter trial, pranlukast dry syrup 7 mg/kg/day achieved significantly better final overall improvement (71.4% versus oxatomide 1 mg/kg/day (37.2% in pediatric patients older than one year with asthma. In two 12-week, open-label trials and in a long-term open-label trial of treatment for up to 24 months, pranlukast dry syrup improved asthma control over baseline values. In a prospective post-marketing surveillance study and a long-term follow-up study, the safety and efficacy of pranlukast dry syrup was confirmed in infants younger than one year with bronchial asthma. In a 4-week, open-label trial, pranlukast dry syrup improved overall health-related quality of life and physical and emotional domain scores over baseline in pediatric patients with asthma. In a randomized, multicenter, double-blind, placebo-controlled, two-period crossover trial, pranlukast dry syrup significantly inhibited exercise-induced bronchospasm in children with asthma compared with placebo. In a modified Childhood Asthma Control Test, pranlukast dry syrup was significantly more effective in controlling asthma in patients younger than 4 years with the common cold. These findings show that pranlukast is useful and beneficial for treating pediatric patients with bronchial asthma. Keywords: pranlukast, leukotriene receptor antagonist, pediatric asthma

  10. Efficacy of naturopathy and yoga in bronchial asthma.

    Science.gov (United States)

    Rao, Y Chitharanjan; Kadam, Avinash; Jagannathan, Aarti; Babina, N; Rao, Raghavendra; Nagendra, Hongasandra Ramarao

    2014-01-01

    The aim of the study was to test the efficacy of a one month in-patient naturopathy and yoga programme for patients with asthma. Retrospective data of 159 bronchial asthma patients, undergoing the naturopathy and yoga programme, was analyzed for Forced Vital Capacity, Forced Expiratory Volume at the end of 1 second, Maximum Voluntary Ventilation and Peak Expiratory Flow Rate on admission, 11th day, on discharge and once in three months for three years. The paired sample t test results showed significant increase in the Forced Vital Capacity and Forced Expiratory Volume from the date of admission up to 6th month (P naturopathy and yoga for the management of bronchial asthma.

  11. Anxiety and depression among patients with Bronchial asthma, chronic obstructive pulmonary disease and diffuse parenchymatous lung diseases

    Directory of Open Access Journals (Sweden)

    Taghreed S. Farag*, Manal R. Hafez*, Taghreed Elshafie**and Omaima I. Abo-Elkheir

    2012-10-01

    Full Text Available Background: Psychosocial stressors, such as death of a spouse or divorce are closely related to relapses and aggravations of respiratory disease pointing to a link between psychological factors and chronic pulmonary disease. Patients with chronic obstructive pulmonary disease (COPD cannot cope adequately with everyday needs. This inadequacy may lead to heightened anxiety and depression, which in turn may worsen the everyday inadequacy. It has been reported that this is probably a factor that leads bronchial asthma (BA and COPD patients to frequent hospital admissions, lower treatment adherence and even intensive care unit hospitalizations.Study objectives: to assess anxiety and depressive symptoms among a sample of Egyptian patients with chronic obstructive pulmonary disease (COPD, bronchial asthma (BA, and diffuse parenchymatous lung diseases (DPLD.Subjects & methods: A cross-sectional study conducted over a one year period on a sample of 258 Egyptian patients with chronic breathing disorders who attending the outpatient chest clinic at Al-Zahraa University Hospital. All patients diagnosed as having COPD, BA or DPLD were enrolled into the study. Anxiety and depression were assessed by using the Hospital anxiety and depression scale (HADS and the Beck Depression Inventory (BDI.Results: Psychiatric disorders were most prevalent among DPLD cases (80.0%, followed by COPD patients (74.0%, while BA group showed the least reported cases (38.8% with psychiatric disorders, with a statistically significant difference among the studied groups (P-value < 0.05.Depression was prevalent among 60.1% (155/258 of the studied cases, of them 23.2% had severe depression, followed by 38.7 % had moderate depression and 38.1% had mild depression. DPLD cases had the highest proportion of severe depression (31.8, COPD cases had the highest proportion of moderate depression (52.4 and BA group had the highest proportion of mild depression (68.4%, with a statistically

  12. [Physical exercise and bronchial asthma].

    Science.gov (United States)

    Endre, László

    2016-06-26

    An article was published in the Lancet in 1935 about the therapy of asthmatic patients, using a special breathing exercise (the authors used a control group, too). Swimming, as a complementary therapy for asthmatic children, was first recommended in 1968, by authors from the United States. In Hungary, regular swimming training for asthmatic children is in use since August, 1981. As the result of this exercise, the physical fitness of asthmatic children (using this method regularly for years) increased dramatically, and it is much better compared to that found in the non asthmatic, non swimming children of the same age group. The requirement for asthma medication decreased, and the severity of their disease significantly decreased, also. On the other hand, asthma is not a rarity even among elite athletes. It is most frequent in the endurance sports (for example in Northern Europe among cross-country skiers its prevalence is between 14-54%, among long distance runners 15-24%, and among swimmers 13-44%). The possible reason is related to the fact that elite athletes inspire 200 liter air/minute (mostly through the mouth). Air pollution and allergens can penetrate in the lower respiratory tract. The air causes cooling and drying of the mucosa of the airways and, as a consequence, mediators are liberated which produce oedema of the mucosa, and bronchoconstriction. Beta-2-receptor agonists inhalation can prevent (or decrease significantly) this phenomenon. These agents are used regularly by elite athletes, too. The non-medical possibilities for prevention include wearing a special mask, frequent ventilation of the swimming pool's air, consumption of omega-3-fatty acid, and inhalation of dry salt (very small, and very clear sodiumchloride particles).

  13. TCM Diet Therapy for Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    DENG Zi

    2009-01-01

    @@ Bronchial asthma is a disease with reversible tracheospasm and tracheostenosis due to excessively increased tracheal-bronchial reactivity induced by sensitinogen or non-sensitinogen. Although its etiology is complicated, the disease is generally caused by internal injury resulting from accumulation of phlegm in the lungs, damage to the spleen by improper diet and impairment of the kidneys by overstrain and excessive coitus;or it can be caused by six exogenous pathogenic factors, with obstruction of the airways by phlegm and upward adverse flow of the lung-qi.

  14. Assessment of life quality in patients with bronchial asthma residing in Krakow in the areas of varying concentrations of particulate matter (PM10

    Directory of Open Access Journals (Sweden)

    Monika Ścibor

    2015-03-01

    Full Text Available Introduction. Asthma is a chronic disease, from which more and more people in the world suffer. It is connected with many bothersome symptoms and limitations, which result in decreased quality of life for the patient. Environmental and individual aspects do not necessarily affect individuals in the same way, so it is necessary to determine which factors have predominantly impacted on an individual, in order to minimize their impact and to take better control over treatment of asthma. The aim of this research was to compare the quality of life among patients with bronchial asthma living in Krakow in the areas where they get exposed to varying concentrations of particulate matter (PM10. Material and methods. The study included 98 adults diagnosed with bronchial asthma. The research was conducted using the AQLQ poll. PM10 concentration was measured in several Malopolska Air Pollution Monitoring Stations located throughout the city. Results. Analyzing the quality of life in the view of symptoms, activity limitations and emotional well being, there was a substantial statistical difference observed in people occupying the areas with different PM10 concentrations. No significant statistical difference was observed in the frequency of asthma symptoms caused by the environmental stimuli between the 2 discussed groups. One group of patients who came to the allergy clinic for control of asthma symptoms and the second group who live in the vicinity of the monitoring stations measuring PM10 concentrations. Conclusions. For many of the cases, the quality of life was not worse for patients with asthma living in an area with slightly elevated concentrations of PM10, and sometimes paradoxically the quality of life was improved. These results show that PM10 concentrations do not correlate with quality of life of asthma patients.

  15. Effect of acupuncture on bronchial asthma.

    Science.gov (United States)

    Yu, D Y; Lee, S P

    1976-11-01

    1. Needle acupuncture was performed at three sites in twenty patients in a clinical attack of bronchial asthma. 2. In all patients the symptoms of bronchoconstriction improved during the attacks when the correct site was stimulated, and in five patients wheezing was abolished. 3. Stimulation at the correct site produced a significant increase in the mean FEV1-0 (58%) and FVC (29%) but not in maximal mid-expiratory flow rate (MMFR; 76%), when compared with the findings before acupuncture, along with a significant fall in the Pa,CO2 and an insignificant fall in Pa,O2. A mild tachycardia was also observed. 4. After acupuncture a greater improvement in FEV1-0, FVC and MMFR was produced by inhalation of isoprenaline. 5. No significant changes in FEV1-0, FVC, MMFR, pulse rate or arterial blood gas tensions occurred after acupuncture at control sites. 6. In four of the patients during clinical remission acupuncture was performed before and after histamine aerosol challenge, but there was no effect on either the severity or the duration of the histamine-induced bronchoconstriction. 7. It is concluded that acupunture probably reduced the reflex component of the bronchoconstriction, but failed to influence direct smooth muscle constriction caused by histamine.

  16. [Coexistence of bronchial asthma and diabetes mellitus type 2--retrospective analysis].

    Science.gov (United States)

    Glück, J; Rogala, B

    1999-01-01

    Bronchial asthma and diabetes mellitus type 2 are often found among adult patients. However, coincidence of these two diseases is very rare. The aim of the study was the retrospective analysis of all patients with bronchial asthma and diabetes mellitus type 2 hospitalised in Department and Clinic of Internal Diseases and Allergology in Zabrze, Silesian School of Medicine in Katowice in 1988-1997. Diabetes mellitus type 2 was diagnosed according to WHO criteria of 1985 and bronchial asthma was diagnosed with the use of American Thoracic Society criteria. Bronchial asthma and diabetes mellitus type 2 occurring together were found in 18 patients (0.3% of all hospitalized patients). In most patients the symptoms of bronchial asthma preceded the diagnosis of diabetes mellitus by a few years. All these cases were heterogeneous in terms of the duration of the diseases, clinical picture, and therapeutical approaches. In patients with bronchial asthma the existence of diabetes mellitus type 2 was not related to use of glikocorticosteroids. Patients in whom the coexistence of bronchial asthma and diabetes mellitus type 2 was found should be subjects of further studies to extend our knowledge of patomechanism of these diseases.

  17. Increased myoepithelial cells of bronchial submucosal glands in fatal asthma.

    Science.gov (United States)

    Green, F H Y; Williams, D J; James, A; McPhee, L J; Mitchell, I; Mauad, T

    2010-01-01

    Fatal asthma is characterised by enlargement of bronchial mucous glands and tenacious plugs of mucus in the airway lumen. Myoepithelial cells, located within the mucous glands, contain contractile proteins which provide structural support to mucous cells and actively facilitate glandular secretion. To determine if myoepithelial cells are increased in the bronchial submucosal glands of patients with fatal asthma. Autopsied lungs from 12 patients with fatal asthma (FA), 12 patients with asthma dying of non-respiratory causes (NFA) and 12 non-asthma control cases (NAC) were obtained through the Prairie Provinces Asthma Study. Transverse sections of segmental bronchi from three lobes were stained for mucus and smooth muscle actin and the area fractions of mucous plugs, mucous glands and myoepithelial cells determined by point counting. The fine structure of the myoepithelial cells was examined by electron microscopy. FA was characterised by significant increases in mucous gland (p = 0.003), mucous plug (p = 0.004) and myoepithelial cell areas (p = 0.017) compared with NAC. When the ratio of myoepithelial cell area to total gland area was examined, there was a disproportionate and significant increase in FA compared with NAC (p = 0.014). Electron microscopy of FA cases revealed hypertrophy of the myoepithelial cells with increased intracellular myofilaments. The NFA group showed changes in these features that were intermediate between the FA and NAC groups but the differences were not significant. Bronchial mucous glands and mucous gland myoepithelial cell smooth muscle actin are increased in fatal asthma and may contribute to asphyxia due to mucous plugging.

  18. Occupational allergic airbone contact dermatitis and delayed bronchial asthma from epoxy resin revealed by bronchial provocation test.

    Science.gov (United States)

    Kanerva, L; Estlander, T; Keskinen, H; Jolanki, R

    2000-08-01

    Diglycidyl ether of bisphenol A (DGEBA) epoxy resins belong to the most common causes of occupational allergic contact dermatitis. DGEBA has on rare occasions caused occupational asthma. Here we present a patient who first developed occupational allergic contact dermatitis (ACD) caused by a single accidental exposure to DGEBA. Then, on continued occupational exposure to DGEBA, the patient developed occupational asthma from DGEBA, in addition to ACD. A bronchial provocation test with DGEBA caused a 36% drop in the peak expiratory flow, reflecting a delayed type of occupational asthma. This bronchial provocation test caused a strong dermatitis of the exposed skin of the face, in accordance with airborne ACD from DGEBA.

  19. Pathogenesis and management of virus infection-induced exacerbation of senile bronchial asthma and chronic pulmonary emphysema.

    Science.gov (United States)

    Yamaya, Metstuo

    2002-06-01

    The number of senile patients with therapy resistant bronchial asthma, chronic pulmonary emphysema increases due to the habit of smoking and increased number of older people, and these inflammatory pulmonary diseases are the leading causes of death worldwide. Rhinoviruses cause the majority of common colds, and provoke exacerbations of bronchial asthma and chronic pulmonary emphysema. Here, I review the pathogenesis and management of rhinovirus infection-induced exacerbation of senile bronchial asthma and chronic pulmonary emphysema.

  20. Features of Extracranial Hemodynamics in Children with Bronchial Asthma

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    S.M. Nedelska

    2014-11-01

    Full Text Available The paper analyzes the performance of extracranial hemodynamics — volumetric and linear blood flow velocity, the state of peripheral vascular resistance and vascular reactivity at ultrasound Doppler examination of the internal carotid and vertebral arteries of 66 children with bronchial asthma and and 22 healthy children. Development of regional hypoperfusion in vertebrobasilar zone, disorders of the carotid system are proven, but these changes have not led to a decrease in the volumetric blood flow velocity in both internal carotid arteries and the total volume of cerebral blood flow, indicating the compensation of hemodynamic disturbances due to the influence of constant rates in volumetric blood flow in the carotid system. Changes in parameters of extracranial hemodynamics in children with bronchial asthma should be considered as predictor of cerebrovascular complications in this group of patients.

  1. Comparison of the Bronchodilative Effects of Salbutamol Delivered via Three Mesh Nebulizers in Children with Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Fumitake Kurosaka

    2009-01-01

    Conclusions: Overall, all 3 mesh nebulizers were useful devices in treating bronchial asthma, although some differences in lung function improvement were evident. The limitation of this study is that subjects did not include patients with severe asthma attacks.

  2. Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

    DEFF Research Database (Denmark)

    Thomson, Neil C; Rubin, Adalberto S; Niven, Robert M

    2011-01-01

    Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure....

  3. Lung sound analysis can be an index of the control of bronchial asthma

    Directory of Open Access Journals (Sweden)

    Terufumi Shimoda

    2017-01-01

    Conclusions: The E/I LF measurement obtained by LSA is useful as an indicator of changes in airway obstruction and inflammation and can be used for monitoring the therapeutic course of bronchial asthma patients.

  4. Ascorbic acid in bronchial asthma

    African Journals Online (AJOL)

    1983-04-23

    Apr 23, 1983 ... tory IgA, serum immunoglobulin and-total haemo- lytic complement levels ... received only standard therapy (Table I). No patients received .... precipitated by virus infections decreased the frequency and severity of asthmatic ...

  5. 老年支气管哮喘临床特点及治疗体会%Clinical Characteristics and Treatment of Elderly Patients with Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    陈根; 朱芸

    2016-01-01

    目的探讨老年人哮喘的临床特点,提高诊治水平。方法回顾性分析我院收治的76例老年支气管哮喘患者的临床资料,并分析治疗效果。结果老年哮喘患者发病年龄大,病程长,易反复、变化大,易并发冠心病、糖尿病、高血压病等疾病,中、重度发作患者易致心功能不全、呼吸衰竭,甚至死亡。结论老年人支气管哮喘症状复杂,伴发症多,预后差,针对个体实施有针对性的治疗,可有效提高患者的生命质量。%Objective To investigate the clinical characteristics of elderly patients with asthma,and to improve the level of diagnosis and treatment. Methods The clinical data of 50 elderly patients with bronchial asthma in our hospital were retrospectively analyzed and the therapeutic effect was analyzed.Results Elderly asthma patients in age of onset,course of disease is long,easily repeated,in a big way to change,I complicated with coronary heart disease,diabetes,hypertension and so on disease,severe attack patients prone to cause heart function failure,respiratory failure and even death. Conclusion Bronchial asthma in the elderly is complex,with many complications and poor prognosis.It can effectively improve the life quality of the patients with targeted therapy.

  6. Disorders of cardiac hemodynamic in attack period of bronchial asthma in children.

    OpenAIRE

    Kondratiev V.А.; Reznyk А.V.

    2016-01-01

    By dopplerechocardiography method there was studied functional state of cardiac ventricles and character of hemodynamic disorders in 48 patients aged 5-17 years in attack period of moderately-severe and severe bronchial asthma. Group of comparison included 40 healthy peers. Disorders of central and peripheral hemodynamic in attack period of bronchial asthma in children were accompanied both by systolic and diastolic dysfunction of the left and right heart ventricles, herewith right ventricle ...

  7. Assessment of pulmonary airway reactivity using high resolution CT after administration of bronchodilator in patients with bronchial asthma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yang Soo; Kim, Young Goo; Song, In Sup; Kim, Dae Soon; Choi, Youn Sun; Kim, Kun Sang; Choi, Byoung Whui [College of Medicine, Chung Ang University, Seoul (Korea, Republic of); Kim, Jong Hyo [Seoul National University, Seoul (Korea, Republic of)

    1994-07-15

    The purpose of this study is to assess the pulmonary airway reactivity in asthmatic patients directly and noninvasively by using high-resolution CT(HRCT). 130 bronchial luminal areas were measured by HRCT in 16 asthmatic patients before and after inhalation of bronchodilator (Salbutamol sulfate). The change of bronchial luminal area on HRCT was analyzed and correlated with the change of forced expiratory volume in 1 second(FEV1) on pulmonary function test in each patient. The mean percentage of increase in luminal areas of the 130 bronchi after bronchodilator inhalation was 95.4% {+-} 103.3%. The group with the smallest luminal areas (lesser than 1.35 mm{sup 2}) was more sensitively increased in area than the group with the largest areas (equal or larger than 3.72 mm{sup 2}); 183.5% versus 63.5%. The mean percentage of increase in FEV1 was 21.7% and there was no statistically significant correlation between the increased degrees of luminal areas and that of FEV1 (r= -0.04). We can measure the bronchial luminal area directly and noninvasively with HRCT and can also estimate the degree of airway reactivity in asthmatic patient by measuring of the changes of bronchial luminal areas after administration of bronchodilator.

  8. Impact of obesity on bronchial asthma in Indian population.

    Science.gov (United States)

    Ramasamy, Anandha K; Gupta, Nitesh; Kumar, Raj

    2014-04-01

    Obesity and asthma are common inflammatory conditions, having presence of both local and systemic inflammation and this relationship is not well understood. This study was undertaken to compare pulmonary function parameters, inflammatory marker like C-reactive protein (hs-CRP), exhaled nitric oxide (FENO) and atopic profile between non-obese and obese bronchial asthma patients in Indian population. The study aims to elucidate the association between the systemic and local inflammatory response relating to obesity in asthmatics. Sixty bronchial asthma patients were recruited for the study, and were divided equally into obese (BMI>30 kg/m(2)) and non-obese (BMIgroups. These were assessed for pulmonary function parameters, blood hs-CRP levels, exhaled breath analysis of nitric oxide and skin prick testing for atopic profile. The study was approved by institutional ethical committee. The mean body mass index (BMI) for the non-obese and obese group was 21.64 kg/m(2) and 34.1 kg/m(2) respectively (P = 0.001). The functional residual capacity (FRC% predicted) (100.9 ± 4.21 vs 80.40 ± 4.03; P = 0.009) and expiratory reserve volume (ERV% predicted) (95.13 ± 6.71 vs. 67.03 ± 4.54; P = 0.001) both were significantly lower in the obese group. The non-obese and obese group had hs-CRP levels of 3.01 mg/L and 4.07 mg/L, respectively; the difference being statistically insignificant (P = 0.15). Similarly, FENO levels of non-obese and obese group were 63.20 ppb and 63.75 ppb, respectively; difference was not statistically significant (P = 0.95). Atopic profile of both the groups did not differ significantly. Obesity does not appear to increase the local and systemic inflammatory responses in bronchial asthma patients in Indian population.

  9. APPLICATION OF BUDESONIDE IN BREASTFEEDING MOTHERS WITH BRONCHIAL ASTHMA

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    E.A. Vishneva

    2009-01-01

    Full Text Available Bronchial asthma is a chronic inflammatory disease of respiratory tract. Breastfeeding mothers suffering from bronchial asthma require attention and control over their health status. The results of research described in the article confirm the need for a continued baseline therapy using the inhalant budesonide in the breastfeeding period and allow mothers suffering from bronchial asthma to be sure of safety in application of modern optimal anti-inflammatory disease treatment and not to worry about a possibility of systemic effect of the medication on the baby.Key words: budesonide, inhalant glucocorticosteroids, breast milk.

  10. Phenotypes Determined by Cluster Analysis in Moderate to Severe Bronchial Asthma.

    Science.gov (United States)

    Youroukova, Vania M; Dimitrova, Denitsa G; Valerieva, Anna D; Lesichkova, Spaska S; Velikova, Tsvetelina V; Ivanova-Todorova, Ekaterina I; Tumangelova-Yuzeir, Kalina D

    2017-06-01

    Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. To identify phenotypes using cluster analysis in moderate to severe bronchial asthma and to compare differences in clinical, physiological, immunological and inflammatory data between the clusters. Forty adult patients with moderate to severe bronchial asthma out of exacerbation were included. All underwent clinical assessment, anthropometric measurements, skin prick testing, standard spirometry and measurement fraction of exhaled nitric oxide. Blood eosinophilic count, serum total IgE and periostin levels were determined. Two-step cluster approach, hierarchical clustering method and k-mean analysis were used for identification of the clusters. We have identified four clusters. Cluster 1 (n=14) - late-onset, non-atopic asthma with impaired lung function, Cluster 2 (n=13) - late-onset, atopic asthma, Cluster 3 (n=6) - late-onset, aspirin sensitivity, eosinophilic asthma, and Cluster 4 (n=7) - early-onset, atopic asthma. Our study is the first in Bulgaria in which cluster analysis is applied to asthmatic patients. We identified four clusters. The variables with greatest force for differentiation in our study were: age of asthma onset, duration of diseases, atopy, smoking, blood eosinophils, nonsteroidal anti-inflammatory drugs hypersensitivity, baseline FEV1/FVC and symptoms severity. Our results support the concept of heterogeneity of bronchial asthma and demonstrate that cluster analysis can be an useful tool for phenotyping of disease and personalized approach to the treatment of patients.

  11. Asthma control during the year after bronchial thermoplasty

    DEFF Research Database (Denmark)

    Cox, Gerard; Thomson, Neil C.; Rubin, Adalberto S.

    2007-01-01

    BACKGROUND: Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma. METHODS: We randomly assigned 112 subjects who had...

  12. Pulmonary hyperinflation and respiratory distress following solvent aspiration in a patient with asthma: expectoration of bronchial casts and clinical improvement with high-frequency chest wall oscillation.

    Science.gov (United States)

    Koga, Toshihiko; Kawazu, Taketoshi; Iwashita, Kazuo; Yahata, Ritsuko

    2004-11-01

    An 18-year-old student with a history of asthma accidentally inhaled organic solvent during a class, with immediate cough and dyspnea that worsened over several hours. He presented in severe respiratory distress, with hypoxemia and marked pulmonary hyperinflation. Administration of inhaled bronchodilator was ineffective because of agitation, and the patient could not be positioned for chest physiotherapy to treat presumed widespread mucus plugging. High-frequency chest wall oscillation (HFCWO) in the sitting position initially caused increased distress but was subsequently tolerated when noninvasive positive-pressure ventilation (NPPV) via nasal mask was initiated. Almost immediately, the patient began expectorating bronchial mucus casts, with concomitant clinical improvement. Endotracheal intubation was avoided, and with aggressive pharmacologic treatment for acute severe asthma and continuation of intermittent HFCWO-NPPV, the patient made a full recovery over the next several days. This case suggests that the combination of HFCWO and NPPV may be helpful in the presence of mucus plugging as a complication of acute inhalation injury or acute severe asthma.

  13. [Research advances in association between pediatric obesity and bronchial asthma].

    Science.gov (United States)

    Zhu, Lian; Xu, Zhi-Liang; Cheng, Yan-Yang

    2016-07-01

    This review article introduces the research advances in the pathophysiological mechanism of obesity in inducing pediatric bronchial asthma, including the role of leptin in obesity and asthma, the association of plasminogen activator inhibitor-1 with obesity and asthma, the association of adiponectin and interleukins with obesity and asthma, and the influence of neurotransmitter on asthma. In particular, this article introduces the latest research on the inhibition of allergic asthma through targeting at the nociceptor of dorsal root ganglion and blocking the signaling pathway of the nociceptor.

  14. Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma.

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    Okazaki,Morihiro

    1991-08-01

    Full Text Available Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001 and adults (r = 0.629, p less than 0.01. However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

  15. [Impact of acupoint heat-sensitive moxibustion on lung function and life quality of patients with chronic persistent bronchial asthma: a randomized controlled study].

    Science.gov (United States)

    Ouyang, Ba-si; Gao, Jie; Sun, Gang; Pu, Ming-zhi; Wu, Yuan-jian; Fan, Chun; Ji, Ling-ling

    2011-11-01

    To observe the impact of heat-sensitive moxibustion on lung function in chronic persistent bronchial asthma and analyze its effect on the improvement of life quality as well as compare its efficacy with Seretide inhaler. Fifty-seven cases were divided into a heat-sensitive moxibustion group (28 cases) and a Seretide group (29 cases) according to the random number table. In heat-sensitive moxibustion group, the therapy of heat-sensitive moxibustion was applied to the regions at the level of Feishu (BL 13) and Geshu (BL 17), or to the heat-sensitized points in the region 6 cun lateral from the 1st and 2nd intercostal spaces in the chest. The treatment was given continuously for 8 days, once per day, 12 treatments should be ensured in the later 22 days of the 1st month. In the later two months since then, 15 treatments should be ensured each month (function such as forced expiratory volume one second (FEV1), TCM symptoms score, Asthma Control Test (ACT) and St George's Respiratory Questionnaire (SGRQ) were assessed and compared between two groups and within group separately. Lung function as FEV1 was improved in either group (P 0.05). But the improvements in general situation, chills, fever and sweating in heat-sensitive moxibustion group were superior to those in Seretide group (both P sensitive moxibustion (P sensitive moxibustion improves lung function, relieves clinical symptoms and benefits life quality for patients with chronic persistent bronchial asthma. It's efficacy on the disease is equal to the internationally-recognized effect of Seretide.

  16. Low power laser therapy in treatment of bronchial asthma

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    Milojević Momir

    2003-01-01

    Full Text Available Introduction Modern concept of acupuncture is based on the fact there are designated locations on the surface of human body, which are related to integrative systems of an organism by means of sensory nerves, correlating and synchronizing organ functioning, depending on external and internal conditions, by means of nervous and neurohumoral regulation of metabolic and regenerative processes, including also mobilization of immunological, protective and antistress reactions. Apart from standard needle acupuncture, other methods of stimulating acupuncture points are also applied. Due to invention of low power lasers, irradiation laser acupuncture has been introduced into routine medical practice, characterized by painless and aseptic technique and outstanding clinical results. Material and methods The investigation was aimed at defining therapeutic effects of low power laser irradiation by stimulating acupuncture points or local treatment of asthma. A prospective analysis included 50 patients treated at the Institute of Pulmonary Diseases in Sremska Kamenica during 2000, 2001 and 2002. Together with conservative treatment of present disease, these patients were treated with laser stimulation of acupuncture points in duration of ten days. During treatment changes of functional respiratory parameters were recorded. Results were compared with those in the control group. The control group consisted of the same number of patients and differed from the examination group only by not using laser stimulation. Results Patients with bronchial asthma presented with significant improvement (p<0,0005 of all estimated lung function parameters just 30 minutes after laser stimulation. Improvements achieved on the third and the tenth day of treatment were significantly higher (p<0,001 to p<0,00005 in the examination group in comparison with the control group. Further investigation confirmed that improvement of measured lung function parameters was significantly

  17. EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA

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    A. V. Eremeeva

    2016-01-01

    Full Text Available Forty-two patients with allergic bronchial asthma (ABA forty persons with non-allergic bronchial asthma (NABA, and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA and NABA we have revealed a significant decrease in FoxP3 mRNA expression levels, in comparison with control group. The patients with severe BA exhibited lowest levels of the FoxP3 mRNA expression as compared with other groups.We revealed a decreased FoxP3 mRNA expression in mononuclear cells from peripheral blood, and an increased IL-17 level in blood serum of patients with bronchial asthma. These results may be considered a manifestation of serious inflammatory process. Probably, the data may reflect a disregulated expression of FoxP3 transcription factor. Therefore, we may assume a key role of FoxP3 for regulation of inflammatory activity in bronchial asthma.

  18. Association of Gene Polymorphisms in Interleukin 6 in Infantile Bronchial Asthma.

    Science.gov (United States)

    Babusikova, Eva; Jurecekova, Jana; Jesenak, Milos; Evinova, Andrea

    2017-07-01

    The genetic background of bronchial asthma is complex, and it is likely that multiple genes contribute to its development both directly and through gene-gene interactions. Cytokines contribute to different aspects of asthma, as they determine the type, severity and outcomes of asthma pathogenesis. Allergic asthmatics undergoing an asthmatic attack exhibit significantly higher levels of pro-inflammatory cytokines, such as interleukins and chemokines. In recent years, cytokines and their receptors have been shown to be highly polymorphic, and this prompted us to investigate interleukin 6 promoter polymorphisms at position -174G/C (rs1800795) and at -572G/C (rs1800796) in relation to asthma in children. Interleukin 6 promoter polymorphisms were analyzed in bronchial asthma patients and healthy children using polymerase chain reaction-restriction fragment length polymorphism analysis. We observed a significant association between polymorphism at -174G/C and bronchial asthma (OR=3.4, 95% CI: 2.045-5.638, P10(-7)). Interleukin 6 polymorphism is associated with bronchial asthma, particularly its atopic phenotype. Expression and secretion of interleukins in asthmatic patients may be affected by genetic polymorphisms, and could have a disease-modifying effect in the asthmatic airway and modify the therapeutic response. Copyright © 2016 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. Use motion games in exercise with children with bronchial asthma

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    Viktoriya Polkovnyk-Markova

    2016-02-01

    Full Text Available Purpose: to analyze the possibility of using moving games in the rehabilitation of children with bronchial asthma. Material & Methods: the modern scientific literature on integrated prevention and treatment of children with asthma. Results: A high frequency of morphological and functional deviations at children with asthma. Classification and examples of mobile games, which can be used for this group of children. Conclusions: the results of modern research that show the effectiveness the use of physical rehabilitation, including moving games.

  20. Impact of obesity on bronchial asthma in Indian population

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    Anandha K Ramasamy

    2014-01-01

    Full Text Available Background and Objective: Obesity and asthma are common inflammatory conditions, having presence of both local and systemic inflammation and this relationship is not well understood. This study was undertaken to compare pulmonary function parameters, inflammatory marker like C-reactive protein (hs-CRP, exhaled nitric oxide (FE NO and atopic profile between non-obese and obese bronchial asthma patients in Indian population. The study aims to elucidate the association between the systemic and local inflammatory response relating to obesity in asthmatics. Materials and Methods: Sixty bronchial asthma patients were recruited for the study, and were divided equally into obese (BMI>30 kg/m 2 and non-obese (BMI<25 kg/m 2 groups. These were assessed for pulmonary function parameters, blood hs-CRP levels, exhaled breath analysis of nitric oxide and skin prick testing for atopic profile. The study was approved by institutional ethical committee. Results: The mean body mass index (BMI for the non-obese and obese group was 21.64 kg/m 2 and 34.1 kg/m 2 respectively (P = 0.001. The functional residual capacity (FRC% predicted (100.9 ± 4.21 vs 80.40 ± 4.03; P = 0.009 and expiratory reserve volume (ERV% predicted (95.13 ± 6.71 vs. 67.03 ± 4.54; P = 0.001 both were significantly lower in the obese group. The non-obese and obese group had hs-CRP levels of 3.01 mg/L and 4.07 mg/L, respectively; the difference being statistically insignificant (P = 0.15. Similarly, FE NO levels of non-obese and obese group were 63.20 ppb and 63.75 ppb, respectively; difference was not statistically significant (P = 0.95. Atopic profile of both the groups did not differ significantly. Conclusion : Obesity does not appear to increase the local and systemic inflammatory responses in bronchial asthma patients in Indian population.

  1. INTERMITTENT HYPOBARIC HYPOXIC STIMULATION IN TREATMENT OF CHILDREN WITH BRONCHIAL ASTHMA AT THE PERIOD OF REHABILITATION

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    G.D. Alemanova

    2009-01-01

    Full Text Available Bronchial asthma is one of the widespread chronic diseases of lungs. Immune mechanisms of disorder are one of the causes which lead to pathologic changes in lungs. The aim: to determine the clinical and immunologic effectiveness of pressure adaptation to the periodical hypobaric hypoxic stimulation of treatment of children with bronchial asthma of prepubertal and pubertal periods. In the present work there were observed the clinical and immunologic parameters of 129 children with the verified atopic bronchial asthma of different degree at the remission period before and after the course of pressure adaptation to the periodical hypobaric hypoxic stimulation in conditions of the medical hypobaric pressure chamber with many seats «Ural'1». Clinic effectiveness of hypobaric hypoxic stimulation revealed in continuation of remissions and diminishing of total numerical score of asthma degree. The positive dynamic indexes of cytokine profile was observed. It revealed in reduction of IL 1_, IL 4, IL 5, IL 18 levels and stimulated production of IFN - in blood serum. The course of hypobaric hypoxic stimulation has the positive impact on the named indexes of the patients with bronchial asthma and its intensity depends on the degree of disease and of the age of the child' patient. Thus the use of pressure adaptation to the periodical hypobaric hypoxic stimulation in treatment of children's with bronchial asthma led to the immunologic positive dynamics, especially of the children of prepubertal period. Determination of the immunologic indexes and the level of the cytokines can be used as the additional tests for the evaluation of the effectiveness of pressure adaptation to the periodical hypobaric hypoxic stimulation of children.Key words: bronchial asthma, periodical hypobaric hypoxic stimulation, cytokines, children.

  2. Is platelet activating factor (PAF an important mediator in bronchial asthma?

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    R. H. Gundel

    1992-01-01

    Full Text Available The development of selective PAF receptor antagonists may provide a novel approach to the treatment of human bronchial asthma. In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen-induced changes in lung function. However, the majority of these models involve acute inflammatory events and transient changes in lung function and, therefore, their relevance to human asthma is questionable. In a recent study with a primate model of chronic airway inflammation and hyperresponsiveness, we have shown that treatment with a PAF receptor antagonist had no effect on reducing chronic inflammation and hyperresponsiveness. Similarly, recent studies in human asthmatics with PAF receptor antagonists have failed to show efficacy in blocking allergen-induced airway responses or to have any steroid sparing effects in patients with ongoing asthma. Thus, it seems that PAF may not be a key mediator which can be blocked and thereby provide therapy for bronchial asthma.

  3. A retrospective study on drug utilization in patients with acute exacerbation of bronchial asthma in adults at tertiary teaching hospital in Bidar

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    Jyothi D. B.

    2017-01-01

    Full Text Available Background: Drug utilization plays a role in helping the health care system to understand, interpret and improve the drug use and continuous quality improvement. It plays an essential part of pharmaco Epidemiological studies. Methods: 100 prescriptions from patients with established diagnosis of acute exacerbation of Bronchial asthma were assessed from the Department of Pulmonary Medicine and the data gathered was analysed using MS Excel. Results: Majority of the prescriptions irrespective of severity received inhalation β2 agonist (formoterol as a bronchodilator. Nebulization route was given for managing the acute exacerbations followed by inhalation route. Hydrocortisone was prescribed to all patients for managing acute Exacerbations. Montelukast was used an adjuvant therapy. Most of them were prescribed combination therapy. Theophylline was prescribed among all the methylxanthines. Conclusions: β2 agonists Combinations and corticosteroids are the most commonly prescribed combination drugs for asthma followed by methylxanthines. The most commonly prescribed asthmatic Medication in combination therapy was inhaled salbutamol with ipratropium followed by intravenous Hydrocortisone and oral Montelukast. The most commonly prescribed methylxanthine was intravenous Theophylline. Nebulization was preferred route to tackle the acute exacerbation of asthmatic symptoms.

  4. CORTISONE IN TREATMENT OF BRONCHIAL ASTHMA

    Science.gov (United States)

    Harris, Marvin S.

    1951-01-01

    Twenty patients with intractable asthma were treated with cortisone on various dosage schedules. Results indicated that a rapid improvement in the asthmatic state may be expected in four to five days with high level dosage of the hormone—usually a total dose exceeding 200 mg. per day at the beginning. If treatment is discontinued after a week, relapse usually will occur within a period of eight days. If small doses are given two or three times weekly, following initial response, relapse may not occur for 20 or 30 days. The interspersed administration of ACTH during an attempt to discontinue cortisone apparently was of no value. It therefore appears that cortisone control of intractable asthma is dependent on large dosage until clinical improvement is obtained, then approximately 100 mg. two or three times a week for maintenance of a reasonable state of health. PMID:14848726

  5. On the value of certain genotypic properties for forming exercise-induced bronchial asthma in children

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    Лорина Алімівна Іванова

    2015-10-01

    Full Text Available Introduction. Exercise-induced bronchial asthma is a separate phenotype of bronchial asthma (BA that defines an exercise-associated transitory obstruction of bronchial tubes, especially decrease of the forced expiration volume for 1 sec. (FEV1 by 10 % and more of an output quantity after the relevant bronchial provocation test. At the same time there is not sufficient elucidation of the role of genetic component especially GSTT1 і GSTM1 gene deletions and\\or mutational polymorphism of еNOS gene in development of exercise-induced bronchial asthma in children.Aim. To study the value of deletion (GSTT1 and GSTM1 genes and mutational (еNOS gene polymorphism in formation of bronchial tubes lability in children with exercise-induced bronchial asthma to optimize individual medioprophylactic recommendations.Materials and methods. During the study there were examined 102 school-aged children with BA in pulmo-allergology department of RSCH in Chernovtsy. To verify the exercise-induced bronchial asthma (EIBA there was studied an exercise tolerance of patients and their bronchial tubes lability in the response to the dosed run and bronchomotor test with inhalation with 200 mkg of salbutamol. And the received results were represented as a bronchial tubes lability indicator (BTLI, % and its components – bronchospasm index (BSI, % and bronchodilation index (BDI, %. 2 clinical groups were formed in examination of children. The first (I, main included 50 schoolchildren with EIBA and the comparative one (II group – 52 children with BA without the signs of exercise-induced bronchospasm (EIBS. Results of research. There was established that the “null” genotype of aforesaid genes is three times more often (10,0 % against 3,85 %, P<0,05in children with exercise-induced bronchial asthma and mutations of еNOS gene ( GT, ТТ genotype take place in every second children. There was detected that the highest bronchospasm indicators are in patients with GSTT1

  6. Effect of 4% lidocaine inhalation in bronchial asthma.

    Science.gov (United States)

    Prakash, G S; Sharma, S K; Pande, J N

    1990-01-01

    The effect of 4% lidocaine inhalation was studied in a single-blind fashion in 18 patients with chronic stable asthma. Inhalation of normal saline solution was used as placebo. None of the parameters except flow rate at 50% of vital capacity (V50) showed any statistically significant change from baseline values. V50 at 15 min was significantly lower (p less than 0.05) after 4% lidocaine inhalation. Considering more than 10% change from the baseline value as significant, 8 of 15 patients showed decrease in airway resistance (Raw) and 7 of the 15 patients showed an increase in specific airway conductance (SGaw) after 15 min of inhalation. However, V50 (8/18 patients), flow rate at 25% vital capacity [V25 (6/15 patients], and forced expiratory flow rate at 25-75% of the vital capacity (FEF25-75) (5/15 patients) showed a decrease after 15 min of 4% lidocaine inhalation. No change in pulmonary function was noted after 30 min of lidocaine inhalation. It is concluded from this study that lidocaine produces a small bronchodilatory effect on the large airways and a bronchoconstrictor effect on the small airways after 15 min of inhalation, but this effect is not statistically significant. It can be safely used as topical agent for bronchoscopy in patients with bronchial asthma.

  7. Sputum as a source of adipokines in bronchial asthma

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    V. N. Mineev

    2014-01-01

    Full Text Available Forty-four patients with allergic (ABA and non-allergic (NABA variants of bronchial asthma (BA were examined to evaluate levels of key adipokines (leptin, resistin, adiponectin in sputum in different variants of BA. Adipokines in sputum and blood plasma were measured by Enzyme-Linked Immunosorbent Assay (ELISA. The indices that reflect the percentage of adipokines in sputum regarding adipokines in plasma of the same patients were worked out to evaluate the ratio of levels of corresponding adipokines in plasma and sputum in patients with BA. Two regularities are clearly seen in the study: the first - levels of proinflammatory adipokines (leptin, resistin in sputum in ABA correlate directly with indicators of respiratory function but levels of anti-inflammatory adipokines (adiponectin in sputum correlate inversely with indicators of respiratory function; the second -correlation of levels of the studied adipokines with indicators of respiratory function are almost not revealed in NABA. The first regularity reflects the important fact that the content of adipokines in bronchial secretion is to a certain extent one of regulating local mechanisms in target organ controlled system levels of corresponding adipokines in exacerbation of BA.

  8. Features of Immune Response to Helicobacter Pylori Infection in Children with Bronchial Asthma

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    M.V. Kalichevska

    2016-07-01

    significantly higher in children of I group versus patients of group II (8.74 ± 0.22 pg/ml and 7.21 ± 0.35 pg/ml, respectively, p < 0.05. Serum concentrations of IL‑4 and IL‑5 were increased in all studied groups compared to the control group and had no correlation with the presence of H.pylori infection. After the treatment of gastrointestinal patho­logy, there was an improvement in parameters of asthma control, which was associated with a significant reduction of IFN-γ and IL‑13 concentrations in group I, and IFN-γ, IL‑5 and -13 — in group II. Conclusion. The presence of H.pylori infection in children with gastroduodenal pathology occurring against the background of bronchial asthma is accompanied by an imbalance of the immune response, which manifested as reduced production of IFN-γ, IL‑4, and IL‑13 increase compared to H.pylori-negative children. Treatment of GI diseases is associated with a decrease in IFN-γ and cytokines mentioned above that clinically promotes the improvement of bronchial asthma control.

  9. CYTOKINE RECEPTORS OF BLOOD LYMPHOCYTES IN CHILDREN WITH BRONCHIAL ASTHMA

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    I.A. Gromov

    2006-01-01

    Full Text Available Blood lymphocyte membrane receptors to IFNγ, IL 2, IL 4, IL 5, IL 8 and IL 10 have been investigated to assess cytokine sensitivity variations in children with asthma. Thirty children aged 5–17 with remission of atopic bronchial asthma ranging from mild to moderate persistent formed the study group. Ten children without any atopic disorders formed the group of controls. The flow cytometry with direct reaction of monoclonal antibodies to the mentioned above cytokine receptors has been used. An increased expression of IL 2 (due to high affinity CD122 subunit and IL 5 receptors has been registered in children with asthma, and so a numbers of cells bearing IL 4 and IL 8 receptors that has trended to be higher. At the same time, there has been a decrease of IFNγ receptor expression an a trend to lower expression of IL 10 receptor in these children.Key words: bronchial asthma, children, interferon-γ, interleukins.

  10. Analysis of Clinical Features of Bronchial Asthma in Elderly Patients%老年支气管哮喘的临床特点分析

    Institute of Scientific and Technical Information of China (English)

    郑颖

    2012-01-01

    Objective To analyze and summarize the clinical features of bronchial asthma in elderly patients. Methods Clinical data of asthma patients treated in the department of internal medicine of our hospital were analyzed and were divided into young group ( 15 ~59 years ) and elderly group ( ≥ 60 years ) according to their age. Sex, smoking, onset age, family history and allergy history, causes and incentives, onset season, clinical features, basic diseases ( chronic diseases and complex diseases) and complications of the two groups were observed and compared. Results Of the 82 asthma patients, 60 cases ( 73. 2% ) were in the elderly group, including 45 males and 15 females, with an average age of 71. 8 years. The number of people who smoke in the elderly group was significantly more than that of the young group, and the males who smoke were significantly more than those of the females. The allergy history and family history and incidence of asthma in autumn in the elderly group showed no statistically significant differences compared with the young group ( P > 0. 05 ) . The causes and incentives and incidence of asthma in spring and summer in the elderly group showed statistically significant differences compared with those of the young group ( P 0. 05 ) . Conclusion Incentives of asthma were mainly infection and climate change in elderly asthma patients, who have high smoking rate, various basic diseases and complications and more cases of serious conditions. The elderly asthma patients can easily suffer from heart failure and respiratory failure with low treatment sensitivity and high mortality rate.%目的 分析和总结老年支气管哮喘的临床特点.方法 分析我院内科经治的哮喘患者的临床资料,按年龄分为青壮年组(15~59岁)和老年组(≥60岁),并对两组的性别、吸烟情况、发病年龄、家族史和过敏史、病因和诱因、发作季节、临床表现、基础疾病(慢性病、合并症)、并发

  11. COMPARATIVE EVALUATION OF CLINICAL EFFICACY AND SA FETY OF SALBUTAMOL AND LEVOSALBUTAMOL MDI IN PATIENTS OF BRONCHIAL ASTHMA

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    Hitender

    2013-02-01

    Full Text Available PURPOSE: Salbutamol is the most common β2-agonist being cur rently used in the treatment of asthma. It was only available as a racemate, a 50:5 0 mixture of the dextro [(S-salbutamol] and levo [(R-salbutamol] rotatory forms. Regular and e xcessive use of racemate can induce paradoxical reactions in some subjects with asthma. The present study, compared MDI Salbutamol with levo [(R-salbutamol] isomer over 8 weeks in terms of clinical efficacy and safety. METHODS: A prospective, parallel design, comparative study last ing eight weeks, involving 80 patient of either sex after taking thei r informed consent. Patients were randomly divided into 2 groups, A and B of 40 patients each. P atients in Group A and Group B were administered Salbutamol MDI two puffs 100 mcg per puf f four times daily and Levosalbutamol MDI two puffs each containing 50 mcg four times dail y respectively. Rescue dose two or more puffs was allowed as required and the number of addi tional doses were counted by patients. Observations were made and analyzed at 0, 4 and 8 w eeks for FEV1, FVC, and PEFR and side effects. RESULTS: Highly significant (p < 0.001 mean percent change in FEV1, FVC and PEFR at 4 and 8 weeks of Group B (Levosalbutamol patients as compared to mean percent change in FEV1 of Group A (Salbutamol patients at 4 weeks and 8 weeks. CONCLUSION: High therapeutic efficacy was observed with the use of the Levosalbu tamol MDI with lesser side effects.

  12. [Macro-and microelements imbalance in etiology and progression of bronchial asthma in children].

    Science.gov (United States)

    Lytvynets', L Ia

    2013-06-01

    The aim of our work was the study of macro-and microelemensts characteristics of the state of the blood serum of children with asthma, depending on the severity. A total of 107 children aged 10 to 18 years with asthma in the acute stage. The results of the proposed asthma control test (GINA, 2011) to the level of asthma control the children were distributed as follows: 34 (31.8%)--with controlled, 47 (43.9%)--partly controlled and 26--with uncontrolled bronchial asthma. Investigation of serum trace elements were determined by atomic absobtsionnoy spectrophotometry. Found that with varying degrees of control of asthma changes were reduction of magnesium, zinc, when excessive amounts of copper and calcium. We show some dizelements in patients with nontrol bronhial asthma. The most pronounced manifestation dyzelements documented in patients with uncontrolled asthma. It is with same with uncontrolled asthma, there are marked hypoxic change, energy shortage, bronchial hyperreactivity, as a result of increasing stress level of response to an antigen, reduce antioxidant enzyme systems, immune system dysfunction. This changes in the macro-and microelement composition of the blood significantly reduce the reserves of the immune system, chronic inflammatory processes in the bronches, which exacerbates the severity of the disease, which in practice requires a differential diagnosis, comprehensive treatment based on identified dyzelements states.

  13. Svær asthma bronchiale

    DEFF Research Database (Denmark)

    von Bülow, Anna; Backer, Vibeke; Porsbjerg, Celeste

    2015-01-01

    Severe asthma is defined by persistent symptoms and frequent exacerbations despite intensive asthma therapy. The prevalence is estimated to be 5-10% of all asthmatics. Severe asthma is responsible for a major burden of illness including low quality of life and a disproportionate use of health......-care resources. The clinical assessment of severe asthma must include verification of the correct diagnosis, adherence to medication, excluding differential diagnosis and identification and treatment of aggravating co-morbidities and trigger factors....

  14. The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma

    DEFF Research Database (Denmark)

    Madsen, F; Holstein-Rathlou, N H; Mosbech, H

    1985-01-01

    A prospective survey aiming to study the predictive value of bronchial histamine challenge was performed on 151 patients with a forced expiratory volume1 (FEV1) above 60% of predicted. According to variations in peak expiratory flow rate (PEFR) and medical history the patients were classified...... as asthmatics (n = 97) or non-asthmatics (n = 54). The diagnostic properties of the challenge were calculated using the statement of Baye. Considering PC20 values below 4.00 mg/ml as positive, the predictive value of a positive test was about 0.80 and the predictive value of a negative about 0.76. When PC20...... was below 0.125 mg/ml the predictive value of a positive test was 1.00, but an increase in PC20 in the range from 4.00 to 16 mg/ml did not increase the predictive value of a negative test. In this study the prevalence of asthma was about 0.6. We therefore conclude that bronchial histamine challenge...

  15. Morgagni’s hernia in a woman with bronchial asthma

    Directory of Open Access Journals (Sweden)

    Gowrinath K

    2014-07-01

    Full Text Available A 59-year-old, other wise asymptomatic lady known to have bronchial asthma was found to have an anterior mediastinal mass on a chest radiograph incidentally obtained as a part of pre-operative work-up for cataract surgery. Computed tomography of the chest confirmed the diagnosis of Morgagni’s hernia.

  16. Correlation between Bronchovascular and Cardiovascular Disorders in Children with Bronchial Asthma: Multifacetedness and Inexhaustibility of Problem Study

    Directory of Open Access Journals (Sweden)

    T.Ye. Shumna

    2014-12-01

    Full Text Available Due to tight functional interrelation between respiratory apparatus and blood circulation, exacerbation of bronchial asthma in children is associated with changes of cardiovascular system. Multifacetedness of this problem determines comprehensive approach to examination of children with bronchial asthma, involving most available methods of heart function evaluation: echocardiographic heart study with Doppler sonography and electrocardiography. Of great importance is investigation of systemic and pulmonary hemodynamics and microcirculation in bronchial asthma depending on its clinical course. It was found that children with exacerbation of bronchial asthma were detected with pulmonary hypertension, which had gradual regression after attack alleviation. During the remission stage, hemodynamics disturbances in lesser circulation were present in long-lasting and severe course of disease. However, the increase in the pulmonary blood flow parameters in patients only in the early period after attack can be regarded as a compensatory response from the lesser circulation to the decline in respiratory function indices. Therefore, despite the great achievements of science in the study of pathophysiological mechanisms and clinical features of bronchial asthma at different ages, it is necessary to continue further study of all aspects of bronchial asthma in children, because it is not as well studied as asthma in adults.

  17. Svær asthma bronchiale

    DEFF Research Database (Denmark)

    von Bülow, Anna; Backer, Vibeke; Porsbjerg, Celeste

    2015-01-01

    Severe asthma is defined by persistent symptoms and frequent exacerbations despite intensive asthma therapy. The prevalence is estimated to be 5-10% of all asthmatics. Severe asthma is responsible for a major burden of illness including low quality of life and a disproportionate use of health-car......-care resources. The clinical assessment of severe asthma must include verification of the correct diagnosis, adherence to medication, excluding differential diagnosis and identification and treatment of aggravating co-morbidities and trigger factors.......Severe asthma is defined by persistent symptoms and frequent exacerbations despite intensive asthma therapy. The prevalence is estimated to be 5-10% of all asthmatics. Severe asthma is responsible for a major burden of illness including low quality of life and a disproportionate use of health...

  18. Disorders of cardiac hemodynamic in attack period of bronchial asthma in children

    Directory of Open Access Journals (Sweden)

    Kondratiev V.А.

    2016-05-01

    Full Text Available By dopplerechocardiography method there was studied functional state of cardiac ventricles and character of hemodynamic disorders in 48 patients aged 5-17 years in attack period of moderately-severe and severe bronchial asthma. Group of comparison included 40 healthy peers. Disorders of central and peripheral hemodynamic in attack period of bronchial asthma in children were accompanied both by systolic and diastolic dysfunction of the left and right heart ventricles, herewith right ventricle was functioning in the mode of hyperdynamic, and left one – in the mode of hypodynamic. Combined systolic-diastolic variant of dysfunction both of right and left ventricles was developing in 58,3% of patients with moderately-severe and in 91,6% of patients with severe bronchial asthma. In the attack period of bronchial asthma in children equal directionality of systolic and diastolic dysfunction of heart ventricles was developing; this was characterized by synchronization of their function. Assessment of functional interaction of the ventricles under conditions of severe asthma attack showed direct and high (r=0,67 correlative interaction between finding of Tei index of the left and right ventricles, which characterize their systolic function; this, under conditions of increased hemodynamic pre-loading testified to compensatory increase of systolic interaction of ventricles. Direct and high (r=0,69 correlative interaction between time indices of isovolumic relaxation of the left and right ventricles, characterizing their diastolic function, testified to compensatory increase of diastolic interaction of ventricles under conditions of increase of hemodynamic post-loading. Imbalance of central and peripheral link of hemodynamic in attack period of bronchial asthma in children testified to development of cardiac insufficiency, which was compensated predominantly at the expense of increase of heart contractions rate.

  19. Pulmonary Artery Agenesis with Bronchial Asthma

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    Hassan Ghobadi

    2014-05-01

    Full Text Available Unilateral Pulmonary Artery Agenesis (UPAA is a rare congenital anomaly during the 4 th  week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR revealed a semi-opaque right hemi-thorax. Chest CT with intra-venous contrast demonstrated absence of the right pulmonary artery and lung parenchyma with hyper-inflated left lung and dextro-position of mediastinum. This case emphasizes that in patients with respiratory compliant and chronic cough CXR must be done to rule out similar diagnosis other than asthma.    

  20. Pulmonary Artery Agenesis with Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Hassan Ghobadi

    2014-05-01

    Full Text Available Unilateral Pulmonary Artery Agenesis (UPAA is a rare congenital anomaly during the 4 th  week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR revealed a semi-opaque right hemi-thorax. Chest CT with intra-venous contrast demonstrated absence of the right pulmonary artery and lung parenchyma with hyper-inflated left lung and dextro-position of mediastinum. This case emphasizes that in patients with respiratory compliant and chronic cough CXR must be done to rule out similar diagnosis other than asthma.    

  1. Bronchial asthma with ABPA presenting as PTE

    Directory of Open Access Journals (Sweden)

    Chandrika Azad

    2013-01-01

    Full Text Available Allergic bronchopulmonary aspergillosis (ABPA, as a complication of asthma, is rare in children. The persistent and poorly-controlled asthma leading to cor pulmonale is not uncommon in adults but rarely described in the pediatric age group. Here, we report a case of asthma and ABPA complicated by pulmonary thrombo-embolism and cor pulmonale. To the best of our knowledge, such association has never been reported in the pediatric age group.

  2. Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population

    Directory of Open Access Journals (Sweden)

    Yipeng Ding

    2015-10-01

    Full Text Available The purpose of this study was to determine the clinical significance of changes in the plasma  adiponectin  concentration  in  patients  with  bronchial  asthma  and  to  test  the association between the single nucleotide polymorphisms (SNPs rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population.We selected 120 cases and 120 controls, and plasma adiponectin, interleukin (IL-6, and tumor  necrosis  factor-alpha  (TNF-α  levels  were  measured  by  enzyme-linked immunosorbent assay (ELISA. In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs and evaluated their association with bronchial asthma using the χ2 test and genetic model analysis.Compared to controls, patients with acute exacerbation of bronchial asthma showedsignificantly lower adiponectin and significantly higher IL-6 and TNF-α levels (p<0.01. Apositive association was found between the rs1501299 SNP and acute exacerbation (OR =1.62; 95% CI= 1.08-2.43; p= 0.019.The inverse correlation between the plasma adiponectin concentration and asthma exacerbation indicates that adiponectin may play a protective role in the pathogenesis of asthma. Meanwhile, our findings suggest that ADIPOQ polymorphisms influence the risk of developing bronchial asthma in Chinese Li population.

  3. Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

    Directory of Open Access Journals (Sweden)

    Alexander Moeller

    2015-06-01

    Full Text Available This review focuses on the methods available for measuring reversible airways obstruction, bronchial hyperresponsiveness (BHR and inflammation as hallmarks of asthma, and their role in monitoring children with asthma. Persistent bronchial obstruction may occur in asymptomatic children and is considered a risk factor for severe asthma episodes and is associated with poor asthma outcome. Annual measurement of forced expiratory volume in 1 s using office based spirometry is considered useful. Other lung function measurements including the assessment of BHR may be reserved for children with possible exercise limitations, poor symptom perception and those not responding to their current treatment or with atypical asthma symptoms, and performed on a higher specialty level. To date, for most methods of measuring lung function there are no proper randomised controlled or large longitudinal studies available to establish their role in asthma management in children. Noninvasive biomarkers for monitoring inflammation in children are available, for example the measurement of exhaled nitric oxide fraction, and the assessment of induced sputum cytology or inflammatory mediators in the exhaled breath condensate. However, their role and usefulness in routine clinical practice to monitor and guide therapy remains unclear, and therefore, their use should be reserved for selected cases.

  4. Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma

    Directory of Open Access Journals (Sweden)

    G. Di Lorenzo

    1995-01-01

    Full Text Available The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis.

  5. Effect of Air Pollution, Contamination and High Altitude on Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Nesriene El margoushy*, Mohamad El Nashar**, Hatem Khairy*, Nihad El Nashar*, Hala Mohamad

    2013-01-01

    , associated with a high rate of rhinitis symptoms and hay fever. In addition to bronchial asthma, prevalence of allergic diseases in a sample of Taif citizens assessed by an original Arabic questionnaire (phase I evidenced a high prevalence of allergic diseases as Urticaria, allergic rhinitis with or without other co-morbidities, and atopic dermatitis. Effect of high altitude on bronchial asthma is controversial; at high altitudes, the concentrations of the allergens are reduced due to the reduced amounts of vegetation, animal populations and human influences, high UV light exposure and low humidity could be contributing factors to the benefits of high altitude other than allergen avoidance. On the contrary, Lower altitudes have significant beneficial effects for bronchial asthma patients but lessen with increasing altitudes; the mountain climate can modify respiratory function and bronchial responsiveness of asthmatic subjects. Hypoxia, hyperventilation of cold and dry air and physical exertion may worsen asthma or enhance bronchial hyper-responsiveness while a reduction in pollen and pollution may play an important role in reducing bronchial inflammation. Increasing attention has to be paid to the potential of urban air toxics to exacerbate asthma. Continued emphasis on the identification of strategies for reducing levels of urban air pollutants is warranted to reduce respiratory diseases and other diseases related to pollution. Efforts for reducing the asthma burden must focus on primary prevention to reduce the level of exposure of individuals and populations to common risk factors, particularly tobacco smoke, frequent lower respiratory infections during childhood, and environmental air pollution (indoor, outdoor, and occupational.

  6. Role of human mast cells and basophils in bronchial asthma.

    Science.gov (United States)

    Marone, Gianni; Triggiani, Massimo; Genovese, Arturo; De Paulis, Amato

    2005-01-01

    Mast cells and basophils are the only cells expressing the tetrameric (alphabetagamma2) structure of the high affinity receptor for IgE (FcepsilonRI) and synthesizing histamine in humans. Human FcepsilonRI+ cells are conventionally considered primary effector cells of bronchial asthma. There is now compelling evidence that these cells differ immunologically, biochemically, and pharmacologically, which suggests that they might play distinct roles in the appearance and fluctuation of the asthma phenotype. Recent data have revealed the complexity of the involvement of human mast cells and basophils in asthma and have shed light on the control of recruitment and activation of these cells in different lung compartments. Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, they might exert a protective effect by modulating certain aspects of innate and acquired immunity and allergic inflammation.

  7. Analysis on Clinical Features and Related Risk Factors of 127 Elderly Patients with Bronchial Asthma%127例老年支气管哮喘患者临床特点及相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    李挺

    2015-01-01

    目的:探讨支气管哮喘临床特点以及其发作危险因素,为预防和控制哮喘发作,减少其发病率提供借鉴。方法收集127例老年支气管哮喘患者(观察组)和同期就诊的112例非支气管哮喘呼吸道疾病患者(对照组)为研究对象,对患者的临床特点以及发作危险因素进行对比分析。结果支气管哮喘患者多在夜间发病,常反复发作,以轻、中度为主。单因素分析发现支气管哮喘发作与过敏史、家族史、吸烟、感染、气候变化、接触有害气体等因素有关(P<0.05),多因素分析发现家族史(P=0.037, OR =1.795)、吸烟(P=0.007, OR =5.027)、感染(P=0.021, OR =2.719)、接触有害气体(P=0.012, OR =5.016)是支气管哮喘的独立危险因素。结论尽量减少或者避免引起哮喘发作的危险因素,对减少哮喘急性哮喘发作、改善患者的预后具有重要意义。%Objective To investigate the clinical features and risk factors of bronchial asthma, so as to provide a theoretical basis for preventing and controlling the asthmatic attack, and reducing the incidence of asthma. Methods 127 elderly patients with bronchial asthma were set as observation group, 112 elderly patients with respiratory diseases and without bronchial asthma in same period were set as control group. The clinical features and risk factors of patients in two groups were analyzed and compared. Results Bronchial asthma were mainly mild and moderate level, and easily occurred at night, with recurrent attacks. Single factor analysis showed that the incidence of bronchial asthma was correlated with allergic history, family history of asthma, smoking, change of weather contact of harmful gas (P <0.05). Multivariate analysis showed that the independent risk factors included family history of asthma (P = 0.037, OR = 1.795), smoking (P =0.007, OR=5.027), infection (P=0.021, OR=2.719) and contract of harmful gas (P=0.012, OR=5.016). Conclusions The prognosis of patients

  8. Serum levels of total IgE and soluble CD23 in bronchial asthma

    Directory of Open Access Journals (Sweden)

    G. Di Lorenzo

    1996-01-01

    Full Text Available The aim of the present study was to compare, during the pollen season, serum levels of total IgE and soluble CD23 (sCD23 from patients with allergic bronchial asthma, with those from healthy subjects. Significantly higher levels of total IgE and sCD23 were found in patients with asthma compared to the control group. Both in normal controls and in asthmatic patients, a significant correlation was shown between the levels of these two molecules. In asthmatic patients, significant correlations were found for both total IgE and sCD23, with lung function measured as bronchial responsiveness to inhaled methacholine. These results suggest that in asthmatic patients, in addition to the study of total serum IgE levels, the assessment of sCD23 serum levels may be helpful in the evaluation of disease activity.

  9. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    2005201 Role of dynamic changes of blood eosinophilia, eosinophil cationic protein and IgE in children with asthma. LOU Jin-tu (楼金吐)?,et al. Children’s Hosp.Med Coll .Zhejiang Univ.Hangzhou 310003. Chin J Emerg Med,2005;14(1) :68-70. Objective: To explore the roles and clinical significance of eosinophilia (EOS) ,eosinophil cationic protein (ECP),IgE and dust mite-skin test in children with asthma. Methods: Peripheral blood amount of EOS,serum concentration of ECP and IgE were de-

  10. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    950302 A synthetical evaluation of occupational asth-ma.LIU Jingyu(刘镜愉),et al.Occup Dis Res Cen-ter,3rd Hosp,Beijing Med Univ,Beijing,100083.ChinJ Industr Hyg & Occouat Dis 1994;12(6)322-325.The occupational exposure and medical history,physical examination,allergen bronchial provocationtest(A-BPT),skin test (ST),specific IgE(S-IgE) andIgG4(S-IgG4) were examined in 43 asthmatic patientswho were suspected to be related to their occupationa

  11. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970320 The role of Interleukin-4 and interferon-y inthe pathogenesis of asthma. WANG Huaqiang(王华强), et al. General Hosp, Jinan Command, Jinan250031. Med J Chin PLA 1997; 22(1): 57-59 Objective: To study the role of interleukin-4(IL-4)and interferon-γ(IFN-7)in the pathogenesis of asth-

  12. Asthma Bronchiale and Exercise-Induced Bronchoconstriction.

    Science.gov (United States)

    Jayasinghe, Harshani; Kopsaftis, Zoe; Carson, Kristin

    2015-01-01

    Exercising regularly has a wide range of beneficial health effects; in particular, it has been well documented to help in the management of chronic illnesses including asthma. However, in some individuals, exertion can also trigger an exacerbation of asthmatic episodes and subsequent acute attacks of breathlessness, coughing, tightness of the chest and wheezing. This physiological process is called exercise-induced bronchoconstriction (EIB) whereby post-exercise forced expiratory volume in 1 s is reduced by 10-15% from baseline. While EIB is highly prevalent in asthmatics and presents with similar respiratory symptoms, asthma and EIB are not mutually exclusive. The aim of this review is to present a broad overview of both conditions in order to enhance the understanding of the similarities and differences distinguishing them as two separate entities. The pathophysiology and mechanisms underlying asthma are well described with research now focussing on defining phenotypes for targeted management strategies. Conversely, the mechanistic understanding of EIB remains largely under-described. Diagnostic pathways for both are established and similar, as are pharmacologic and non-pharmacologic treatments and management approaches, which have enhanced success with early detection. Given the potential for exacerbation of asthma, exercise avoidance is common but counterproductive as current evidence indicates that it is well tolerated and improves quality of life. Literature supporting the benefit of exercise for EIB sufferers is at present favourable, yet extremely limited; therefore, future research should be directed in this area as well as towards further developing the understanding of the pathophysiology and mechanisms underpinning both EIB and asthma.

  13. A rare case of Mounier-Kuhn syndrome with bronchial asthma

    Directory of Open Access Journals (Sweden)

    Joshi Tanay

    2016-07-01

    Full Text Available Tracheobronchomegaly(Mounier–Kuhn syndrome is dilatation of the trachea and major bronchi because of atrophy or absence of elastic fibers and smooth muscle cells .Patients presenting to primary care physician with lower respiratory tract symptoms like dyspnoea and wheezing are often diagnosed with COPD or asthma and started on treatment. There are uncommon conditions like Mounier-Kuhn syndrome (MKS that can present with similar symptoms and it is important for the primary care physician to keep them in mind when evaluating the patients. It is important to identify MKS, as early recognition can lead to better management and prevention of complications. Very few cases of MKS with Bronchial Asthma have been reported so far. We present a case of 65 year old male who presented with intermittent episodes of cough with productive sputum ,wheezing and breathing difficulty since last 35 years and was treated for Bronchial Asthma since last 25 years. He was later diagnosed with Mounier–Kuhn syndrome with Bronchial Asthma by clinical history supported by Radiological evidences.

  14. Effect of parenteral magnesium sulfate on pulmonary functions in bronchial asthma.

    Science.gov (United States)

    Sharma, S K; Bhargava, A; Pande, J N

    1994-01-01

    Eighteen patients with bronchial asthma were studied in a single-blind fashion. Each patient received an infusion of magnesium sulfate (MgSO4.7H2O 50% W/V) in a dose equivalent to 10 mmol of elemental magnesium. The airways resistance showed a significant decrease (p significantly (p V50 (p statistically significant increase (p Significant changes in Raw (p significant side effects were observed with MgSO4 infusion. It is concluded that modest improvement in airways resistance and specific conductance and only small improvement in maximal expiratory flow rates is consistent with a predominant effect of MgSO4 on large airways in patients with bronchial asthma.

  15. Achievement of control of bronchial asthma at the stage of medical rehabilitation

    Directory of Open Access Journals (Sweden)

    Grygus I.M.

    2011-02-01

    Full Text Available An inspection is conducted 70 patients on intermittent bronchial asthma at the stage of intensifying. The special program of medical rehabilitation, which includes the modified methods of medical physical culture, physical therapy facilities, is offered in permanent establishment. Application of this program brought to the height of size of Asthma Control Test from 17,41±0,35 to 24,03±0,32 points over. Control of flow of disease which did not come at treatment of patients only by medicinal preparations was arrived at in all cases of application of the program of medical rehabilitation.

  16. Japanese pediatric guideline for the treatment and management of bronchial asthma 2012.

    Science.gov (United States)

    Hamasaki, Yuhei; Kohno, Yoichi; Ebisawa, Motohiro; Kondo, Naomi; Nishima, Sankei; Nishimuta, Toshiyuki; Morikawa, Akihiro; Aihara, Yukoh; Akasawa, Akira; Adachi, Yuichi; Arakawa, Hirokazu; Ikebe, Toshiichi; Ichikawa, Kunio; Inoue, Toshishige; Iwata, Tsutomu; Urisu, Atsuo; Ohya, Yukihiro; Okada, Kenji; Odajima, Hiroshi; Katsunuma, Toshio; Kameda, Makoto; Kurihara, Kazuyuki; Sakamoto, Tatsuo; Shimojo, Naoki; Suehiro, Yutaka; Tokuyama, Kenichi; Nambu, Mitsuhiko; Fujisawa, Takao; Matsui, Takehiko; Matsubara, Tomoyo; Mayumi, Mitsufumi; Mochizuki, Hiroyuki; Yamaguchi, Koichi; Yoshihara, Shigemi

    2014-08-01

    A new version of the Japanese pediatric guideline for the treatment and management of bronchial asthma was published in Japanese at the end of 2011. The guideline sets the pragmatic goal for clinicians treating childhood asthma as maintaining a "well-controlled level" for an extended period in which the child patient can lead a trouble-free daily life, not forgetting the ultimate goal of obtaining remission and/or cure. Important factors in the attainment of the pragmatic goal are: (i) appropriate use of anti-inflammatory drugs; (ii) elimination of environmental risk factors; and (iii) educational and enlightening activities for the patient and caregivers regarding adequate asthma management in daily life. The well-controlled level refers to a symptom-free state in which no transient coughs, wheezing, dyspnea or other symptoms associated with bronchial asthma are present, even for a short period of time. As was the case in the previous versions of the guideline, asthmatic children younger than 2 years of age are defined as infantile asthma patients. Special attention is paid to these patients in the new guideline: they often have rapid exacerbation and easily present chronic asthmatic conditions after the disease is established.

  17. Indications for the use of bronchial thermoplasty in severe asthma.

    Science.gov (United States)

    Dheda, Keertan; Koegelenberg, Coenraad F N; Esmail, Aliasgar; Irusen, Elvis; Wechsler, Michael E; Niven, Rob M; Chung, Kian Fan; Bateman, Eric D

    2015-09-18

    Approximately 5% of the ~3 million asthmatics in South Africa have severe asthma that is associated with substantial morbidity, cost, absenteeism, preventable mortality, and the requirement for costly chronic medication that may be associated with significant adverse events. There is an unmet need for alternative safer and more effective interventions for severe asthma. A recently introduced option, bronchial thermoplasty (BT), imparts radiofrequency-generated heat energy to the airways to cause regression of airway smooth muscle. The effectiveness of this technique has been confirmed in randomised control trials and is now endorsed by several international guidelines, including the Global Initiative for Asthma (GINA) guideline, the British Asthma Guideline, and the UK National Institute of Clinical Excellence (NICE) guideline. We recommend BT as a potential therapeutic intervention for severe uncontrolled asthma, provided that it is performed by an experienced pulmonologist at an accredited centre and done within the broader context of appropriate management of the disease by doctors experienced in treating difficult-to-control asthma.

  18. [Investigation into relationship between chronic obstructive pulmonary disease, bronchial asthma, and type 2 diabetes].

    Science.gov (United States)

    Kobylianskiĭ, V N; Babadzhanova, G Iu; Suntsov, Iu I

    2009-01-01

    We studied the relationship between bronchopulmonary pathology (chronic pulmonary disease, CPD, and bronchial asthma, BA) and type 2 diabetes (DM2). The two conditions were shown to be underlain by inflammation of different character. In patients with CPD it leads to DM2. Concomitant CPD and BA significantly increase the risk of DM2 and require the development of measures for its diagnosis and prevention.

  19. [THE ROLE OF VEGETATIVE DYSREGULATION IN THE FORMING OF BRONCHIAL ASTHMA IN CHILDREN].

    Science.gov (United States)

    Litvinets, L Ya

    2014-01-01

    To study the heart rate variability (HRV) in bronchial asthma (BA) examined 107 children aged 10 to 18 years old with asthma exacerbation. As a result of the application of asthma control test (GINA, 2011) on the level of controlled asthma children were distributed as follows: 34 (31.8%)--with controlled (CBA), 47 (43.9%)--is partly controlled (PCBA) and 26 (24.3%)--with uncontrolled asthma (UCBA). The control group consisted of 10 healthy children of similar age. All investigated HRV measured on the device "KardyLab BCC" (Kharkov, 2009) with holding orthostatic test to assess the type of autonomic regulation, changes in autonomic balance and adaptive reserves. Analyzed time (SDNN, IN, IWT) and spectral (TP, HF, LF, VLF, LF/HF) HRV indices. Investigation of heart rate variability in children with different degrees of severity of asthma indicated presence of autonomic dysfunction syndrome. It is shown that changes in the autonomic nervous system patients differ depending on the degree controlled asthma. Thus, in children with CBA tendency to sympathicotonia in patients with UCBA often reveals signs of parasympathetic and autonomic imbalance. Severe asthma accompaniedby signs. of autonomic dysfunction: increase vagotonia, the reaction to stress and'rapid depletion of compensatory mechanisms in the restoration of homeostasis against parasympathetic dominance.

  20. Abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-Bref) in north Indian patients with bronchial asthma: an evaluation using Rasch analysis

    OpenAIRE

    Aggarwal, Ashutosh N.; Agarwal, Ritesh; Gupta, Dheeraj

    2014-01-01

    Background: There is no disease-specific instrument to describe health-related quality of life (HRQoL) in Indian patients with asthma. However, an abbreviated World Health Organization Quality of Life questionnaire (WHOQOL-Bref), a generic Hindi HRQoL measure, has been developed and validated in India. Aims: To evaluate the WHOQOL-Bref in adult patients with asthma and to test possible modifications to the instrument to improve its psychometric adequacy. Methods: Sixty-seven patients with ast...

  1. Treatment of bronchial asthma with low-level laser in attack-free period at children

    Science.gov (United States)

    Ailioaie, C.; Ailioaie, Laura

    2000-06-01

    Bronchial asthma is a common disease in both the pediatric and adult populations, characterized by wide variations over short periods of time in resistance to airflow in intrapulmonary airways. A primary goal in the use of low- level laser therapy (LLLT) was the safe, effective and rapid palliation of symptoms owing to tracheal or bronchial obstruction. We have investigated the effects of LLLT comparatively with other modality trials in children's asthma. In the study were included 98 patients aged 10-18 years diagnosed with moderate or severe asthma, in attack- free period. The patients were divided into 3 groups. Group 1 received only laser therapy using extra meridian acupuncture points and scanning technique. Group 2 was treated only with inhaled Serevent 2 X 25 micrometers , two times daily, 3 months. Group 3 was tread with Theophylline retard in dosage of 15-mg/kg/12 h, 3 months. At the end of treatment we remarked a noticeable improvement of the clinical, functional and immunological characteristics at 83 percent of patients in group 1, comparatively with only 70 percent (group 2) and 53 percent (group 3). The LLLT had a very good action on bronchial patency , displayed an immunocorrecting action and is recommended in attack-free periods at children.

  2. The impact of allergic rhinitis and asthma on human nasal and bronchial epithelial gene expression.

    Directory of Open Access Journals (Sweden)

    Ariane H Wagener

    Full Text Available BACKGROUND: The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium. OBJECTIVE: Defining gene expression profiles of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles. METHODS: This cross-sectional study included 18 subjects (6 allergic asthma and allergic rhinitis; 6 allergic rhinitis; 6 healthy controls. The estimated false discovery rate comparing 6 subjects per group was approximately 5%. RNA was extracted from isolated and cultured epithelial cells from bronchial brushings and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array. Data were analysed using R and Bioconductor Limma package. For gene ontology GeneSpring GX12 was used. RESULTS: The study was successfully completed by 17 subjects (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls. Using correction for multiple testing, 1988 genes were differentially expressed between healthy lower and upper airway epithelium, whereas in allergic rhinitis with or without asthma this was only 40 and 301 genes, respectively. Genes influenced by allergic rhinitis with or without asthma were linked to lung development, remodeling, regulation of peptidases and normal epithelial barrier functions. CONCLUSIONS: Differences in epithelial gene expression between the upper and lower airway epithelium, as observed in healthy subjects, largely disappear in patients with allergic rhinitis with or without asthma, whilst new differences emerge. The present data identify several pathways and genes that might be

  3. Relationship between Chlamydia pneumoniae infection and occurrence of bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    SHI Yi; ZHENG Wen; XIA Xi-rong; ZHANG Xi-long; TONG Mao-rong; FENG Gen-bao; ZHAO Bei-lei; HU Lan-ping

    2002-01-01

    Objective: To study the relationship between Chlamydia pneumoniae (C. Pneumoniae) infection and asthma exacerbation. Methods: A prospective study of C. Pneumoniae infection was conducted in 75 patients with asthma and 63 patients with respiratory tract infection, and 100 blood donors served as controls.The presence of infection was convinced by the polymerase chain reaction and direct immunofluorescence assay for C. Pneumoniae DNA from throat swab specimens and micro-immunofluorescence testing for C. Pneumoniae-specific IgG, IgM and IgA antibodies. Results: Prevalence of specific IgG in asthma patients (81.3%) was higher than that of the blood donors (68. 0%, P<0. 05) and was not significantly different from respiratory tract infection patients (68. 0%, P>0. 05). The acute C. Pneumoniae infection rate of symptomatic asthma patients (59.4%) was markedly higher than that of respiratory tract infection patients (34.9%, P<0. 05). The average titer of C. Pneumoniae IgG instead of IgA in asthma patients (48. 38±6. 94)was significantly higher than respiratory tract infection patients (24. 70±8. 77, P<0. 05). Other pathogens were identified in 12 of 21 (57. 1%) asthma patients with C. Pneumoniae. The symptoms of 7 asthma patients with C. Pneumoniae infection were improved through antibiotic treatment. Conclusion: The findings suggest a possible role of C. Pneumoniae infection in asthma.

  4. The role of pneumococcal infection in development of exacerbations in children with bronchial asthma and obstructive bronchitis

    Directory of Open Access Journals (Sweden)

    N.V. Kukhtinova

    2011-01-01

    Full Text Available Pneumococcal infection remains the key cause of severe diseases of lower airways and deaths in children. The objective: to study the role of pneumococcal infection in pathogenesis of exacerbations of recurrent obstructive pulmonary diseases. Methods: etiological structure of lower airways infections was evaluated in 125 patients 1–15 years old with bronchial asthma or recurrent bronchitis. Results: etiologic role of Streptococcus pneumoniae in development of low airways infections was detected in 48% of patients with atopic asthma, 85% — with asthma without atopy, 97% — with recurrent bronchitis. Repeated microbiological examination confirmed chronic carriage of S. рneumoniae in nasopharinx in 31% of patients. Conclusion: early active prophylaxis with vaccine against pneumococcal infection including conjugated vaccines is able to prevent further progression of a disease.Key words: children, bronchial asthma, obstructive bronchitis, exacerbation, pneumococcal infection.

  5. [Efficiency of kinesi- and hydrokinesitherapy in children with bronchial asthma].

    Science.gov (United States)

    Surovenko, T N; Iashchuk, A V; Iansons, T Ia; Ezhov, S N

    2003-01-01

    The authors review efficiency of various programs of kinesi and hydrokinesitherapy of children with atopic bronchial asthma (BA). Efficiency of the treatment was assessed by quality of life using the questionnaire by A. West, D. French "Childhood asthma questionnaire" (adapted for Russia by V. I. Petrov et al). Monitoring of the activity of allergic inflammation of the upper respiratory tracts was performed by examination of the nasal lavage fluid for nitric oxide metabolites, of the lower respiratory tracts--by the metabolites in the condensate of the expired air. It is shown that hydrokinesitherapy raises BA children's quality of life and declines inflammation activity leading to reduction of the number of BA exacerbations and hospitalizations. The above criteria of the treatment efficacy proved sensitive.

  6. Bronchial Challenge With Tri a 14 as an Alternative Diagnostic Test for Baker's Asthma.

    Science.gov (United States)

    Armentia, A; Garrido-Arandia, M; Cubells-Baeza, N; Gómez-Casado, C; Díaz-Perales, A

    2015-01-01

    Baker's asthma (BA) is the most prevalent occupational respiratory disease in developed countries. It is caused by inhalation of wheat dust in the working environment and affects 1%-10% of workers in the baking industry. Diagnosis of BA is based on bronchial challenge with wheat, a technique that carries a high risk for patients. The wheat lipid transfer protein Tri a 14 is a major allergen in BA. The aim of our study was to characterize Tri a 14 as a marker of BA in order to prevent patients from having to undergo bronchial challenge with wheat. The study population comprised 55 patients selected at the Rio Hortega Hospital, Valladolid, Spain. Patients with BA were diagnosed using a skin prick test (SPT) with wheat and Tri a 14 and bronchial challenge test (BCT) with wheat. Patients with food allergy had a clear clinical history of allergy to peach confirmed by positive SPT to peach extract and Pru p 3. All patients in the BA group had a positive SPT result with wheat (100%), and most had positive results with Tri a 14 (95%). A positive BCT result with Tri a 14 was also observed in 22 of 27 of the patients with BA (82%). The response to Tri a 14 was specifically associated with BA. Tri a 14 is a good marker of BA and can be used in SPT and BCT as an alternative diagnostic method, thus avoiding bronchial challenge with wheat and reducing the risk associated with this technique.

  7. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008287 The transcription levels of linker for activation of T cell and its upstream regulatory factors in T cells of asthmatic patients. GUO Xuejun(郭雪君), et al. Dept Respir Med, Xinhua Hosp, Shanghai Jiaotong Univ Shanghai 200092. Chin J Tuberc Respir Dis 2008;31(2):125-128.Objective To examine the mRNA expression of the linker for activation of T cell(LAT)and its upstream regulatory factors(Syk,Lck and ZAP-70)in the peripheral blood Tcells of asthmatic patients.Methods

  8. Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009186 The clinical significance of noninvasive inflammatory markers in exhaled breath condensate and induced sputum in persistent asthmatic patients. TAN Chengwu(谭成戊),et al.Dept Respir Med,West China Hosp,Sichuan Univ,Chengdu,Sichuan 610041.Chin J Interm Med,2009;48(4):299-303.

  9. Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment.

    Science.gov (United States)

    Chen, Chuan-Liang; Li, Hong; Xing, Xiao-Hong; Guan, Hai-Shan; Zhang, Jian-Hua; Zhao, Jun-Wu

    2015-01-01

    Bronchial asthma is a worldwide disease with high incidence. It not only harms children's physical and mental health, but it also brings a heavy burden to their families as well as the society. However, the trigger and pathogenesis of the disease remain unclear. This study aimed to analyze TRPV1 gene mutation and expression of cytokines in children with acute bronchial asthma before and after treatment, thus providing theoretical guidance for the diagnosis and treatment of bronchial asthma in children. Real-time quantitative polymerase chain reaction was adopted to detect TRPV1 mRNA expression level and enzyme-linked immuno sorbent assay was used to detect the serum total IgE level, eosinophil (EOS) number, IL-4, IL-5, and interferon (IFN) gamma levels in peripheral venous blood of children in the healthy control group and asthma group before and after treatment. Logistic regression analysis was applied to analyze the most essential factor inducing bronchial asthma in children. TRPV1 mRNA level of peripheral blood in the asthma group was higher than that in the control group before treatment (p asthma in children. TRPV1 gene mutation was closely related to bronchial asthma in children, which provided a theoretical basis for the treatment and prognosis of children with bronchial asthma.

  10. Peculiarities of the Lifestyle and Psychological State of Primary Schoolchildren with Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Alexandra M. Timofeeva

    2017-01-01

    Full Text Available The need to develop an integrated approach to the treatment of children with bronchial asthma is conditioned by a significant increase in morbidity, emergence of more severe forms of the disease and a lack of radical treatment methods. Along with the development and implementation of modern drug treatment methods, the most topical issues are a consideration of the socio-psychological characteristics of patients and psychological and pedagogical support of children during treatment. Study Objective: To study the lifestyle peculiarities of primary schoolchildren (7–10 years with bronchial asthma and their psychological state. Patients and Methods. The study included children with bronchial asthma (atopic form, partially controlled course as well as conditionally healthy peers (health groups I and II as a comparison group. The psychological status of the observed was assessed using Dembo-Rubinstein self-evaluation method, modified «Human Figure» method, and Varga-Stolin parental relationship test. Results. The study involved 75 children (mean age 8.2 ± 0.6 years, including girls 59%, illness duration 3.2 ± 0.5 years and their parents (mothers made 79% of them. The comparison group consisted of 54 conditionally healthy children (mean age 8.4 ± 0.3, girls 54% and their parents (mothers — 85%, fathers — 15%. It is shown that the lifestyle of primary schoolchildren changed due to illness distorts the process of personality development and leads to the emergence of difficulties in the emotional and personality sphere: a reduced background of mood (35; 46.6% versus 11; 20%, blockage of experiences and difficulties in their verbalization (56; 75% versus 25; 46%, defensive-aggressive type of behavior in a stress situation (68; 91% versus 25; 46%, pronounced intrapersonal conflict (47; 62% versus 32; 59%, and communication problems (unsociability, restriction in communication, social fears. Conclusion. Bronchial asthma changes the child

  11. Eosinophil cationic protein mRNA expression in children with bronchial asthma.

    Science.gov (United States)

    Yu, H Y; Li, X Y; Cai, Z F; Li, L; Shi, X Z; Song, H X; Liu, X J

    2015-11-13

    Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 children with bronchial asthma and 21 healthy children by using reverse-transcriptase polymerase chain reaction to understand the role of ECP in children with bronchial asthma. The children with bronchial asthma were segregated into acute-phase and stable-phase groups, based on the severity of the illness. Serum ECP mRNA expression in children with bronchial asthma (0.375 ± 0.04) was significantly higher than that in healthy controls (0.20 ± 0.02; P children in the acute-phase group showed higher ECP mRNA expression level (0.44 ± 0.06) than those in the stable-phase (0.31 ± 0.03) and healthy control groups (0.20 ± 0.02; P children with bronchial asthma.

  12. Current practice in assessment and treatment of bronchial asthma in young males in Italy.

    Science.gov (United States)

    Ferrante, E; Pantaleo, C; Quatela, M; Fuso, L; Basso, S; Pistelli, R

    2000-10-01

    The aim of the study was to evaluate, in a sample of young asthmatics in Italy, the current practice in assessment and treatment of asthma after the publication of guidelines. Young soldiers who declared bronchial asthma at the beginning of the compulsory military service were evaluated. One-hundred and thirty-eight subjects with confirmed asthma were selected. Sixty-seven subjects (48.5%) had had at last one spirometry, and only one subject had underwent peak flow monitoring at home; most of the subjects (96.8%) had had prick tests. More of the 50% of the subjects with bronchial obstruction or with severe bronchial hyperresponsiveness, with clinical moderate or severe asthma, had used only bronchodilators or no therapy at all in the preceding year. In this sample of young asthmatics, the lung function tests were still underutilized for the diagnosis and follow-up of bronchial asthma; moreover, the inhaled anti-inflammatory drugs were still underutilized.

  13. HYPOXIHYPOBAROTHERAPY IN REGULATION OF NEUROHUMORAL AND CYTOKINE RESPONSE IN REHABILITATION OF CHILDREN WITH BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    G.D. Alemanova

    2009-01-01

    Full Text Available The effect of hypoxihypobarotherapy in children with bronchial asthma at the rehabilitation stage on the clinicals and dynamics of immunity response to the disease has been studied. Clinical efficacy of hypoxihypobarotherapy was 63,3% in moderate asthma. Positive dynamics of immunological indicators and neuropeptides have manifested in reduced of IL 4, IL 5, IL 18 and substance P serum levels. Use of hypoxihypobarotherapy in children with bronchial asthma has resulted in favourable clinical and immune dynamics and positive alteration of neurohumoral regulation mechanisms and reduced intensity of neurogenic inflammation. Determining immunological indicators, including neuropeptides, may serve as an additional criterion for assessing the efficacy of this treatment in children with bronchial asthma at the rehabilitation stage.Key words: children, bronchial asthma, pneumotherapy, hypoxihypobarotherapy, neuropeptides, cytokines.

  14. Asthma patients who smoke have signs of chronic airflow limitation before age 45

    DEFF Research Database (Denmark)

    Harmsen, Lotte; Gottlieb, Vibeke; Rasmussen, Linda Makowska;

    2010-01-01

    The frequency of smokers among asthma patients often mirrors the frequency of smokers among healthy individuals. Smoking has been shown to increase the lung function decline in adult asthma patients and change the composition of the bronchial inflammation....

  15. APPLICATION OPPORTUNITIES FOR THE NONMEDICAMENTOUS PREVENTION AND TREATMENT METHODS OF BRONCHIAL ASTHMA IN CHILDREN

    Directory of Open Access Journals (Sweden)

    D.A. Bezrukova

    2007-01-01

    Full Text Available In the article, the authors justify the necessity to apply non medicamentous treatment methods to the children with bronchial asthma. The scientists familiarize us with a new me dication, whose effect is based on the noninvasive impact of the electromagnetic radiation of the knowingly non thermal intensity. It is for normalization of the disturbed function of the respiratory system. The researchers showed the efficiency of the above said innovative medication, while treating bronchial asthma among children with no side effects whatsoever.Key words: bronchial asthma, nonmedicamentous treatment methods, children.

  16. Elevated levels of manna-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associated with a novel intronic polymorphism in MBL

    DEFF Research Database (Denmark)

    Kaur, S.; Gupta, G.K.; Shah, A.;

    2006-01-01

    Mannan-binding lectin (MBL), an important component of innate immunity, binds to a range of foreign antigens and initiates the lectin complement pathway. Earlier studies have reported high plasma MBL levels in allergic patients in comparison to healthy controls. In view of varied plasma MBL levels...... being determined by genetic polymorphisms in its collagen region, we investigated the association of single nucleotide polymorphisms (SNPs) in the collagen region of human MBL with respiratory allergic diseases. The study groups comprised patients of bronchial asthma with allergic rhinitis (n = 49......) and allergic bronchopulmonary aspergillosis (APBA) (n = 11) and unrelated age-matched healthy controls of Indian origin (n = 84). A novel intronic SNP, G1011A of MBL, showed a significant association with both the patient groups in comparison to the controls (P

  17. Asthma patients who smoke have signs of chronic airflow limitation before age 45

    DEFF Research Database (Denmark)

    Harmsen, Lotte; Gottlieb, Vibeke; Rasmussen, Linda Makowska

    2010-01-01

    The frequency of smokers among asthma patients often mirrors the frequency of smokers among healthy individuals. Smoking has been shown to increase the lung function decline in adult asthma patients and change the composition of the bronchial inflammation.......The frequency of smokers among asthma patients often mirrors the frequency of smokers among healthy individuals. Smoking has been shown to increase the lung function decline in adult asthma patients and change the composition of the bronchial inflammation....

  18. Overlap of obstructive sleep apnea and bronchial asthma: Effect on asthma control

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    Mohamed Zidan

    2015-04-01

    Conclusion: A high index of suspicion is warranted for the overlap of OSA and asthma, particularly in the presence of obesity, GERD, and in patients with severe asthma. Individualized therapy addressing these moderating factors is warranted for optimal health outcomes. Recognition and treatment of OSA in asthmatics is an important element in improving asthma control.

  19. INTERACTION OF TRANSCRIPTION FACTORS PAX-5 AND STAT6 IN PATHOGENESIS OF ALLERGIC BRONCHIAL ASTHMA

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    V. N. Mineev

    2014-01-01

    Full Text Available The aim of this work was to study an opportunity of coordinated expression of PAX-5 and STAT6 in bronchial asthma (BA development. 35 healthy controls, 83 patients with allergic bronchial asthma (ABA and 63 patients with nonallergic bronchial asthma (NABA o different severity were observed. To evaluate PAX- 5 and β-actin mRNA levels, a reverse transcription-PCR with endpoint detection was applied. To determine STAT6 and pSTAT6 protein levels, ECL Western blotting protocols (Amersham was used. A negative correlation was revealed between РАХ-5 and STAT6 mRNA expression levels in control group and in ABA. In NABA patients, the appropriate correlations were nonsignificant. Expression of РАХ-5 mRNA in ABA with normal IgE levels showed a significant negative correlation with that of STAT6. Meanwhile, expression levels of active pSTAT6 form in patients with high IgE and eosinophilia did negatively correlate with РАХ-5 mRNA expression. In ABA, effects of IL-4 caused a more significant decrease of РАХ-5 mRNA as compared with those in control group. The strongest negative correlation between РАХ-5 mRNA expression and STAT6 levels was revealed in groups with higher levels of mRNA РАХ-5 and lower levels of STAT6. The revealed negative correlations between STAT6 levels and РАХ-5 mRNA expression suggest that STAT6 may inhibit PAX-5 transcription in ABA group, thus, probably, promoting differentiation of B cells into plasma cells.

  20. Influence of the tobacco smoking on the bronchial asthma in teenagers

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    B. Ts. Batozhargalova

    2012-01-01

    Full Text Available Comparative epidemiological research on studying prevalence tobacco smoking and respiratory symptoms among rural teenagers with bronchial asthma. Control group have made non-smoking (n = 59, and skilled — smoking teenagers (n = 72. Prevalence of smoking among adolescents with bronchial asthma has made 55% against 44,3% on the average at adolescents (p < 0.05. At smokers sick of a bronchial asthma the presence of respiratory complaints, level of СO in exhaled air and urinary cotinine has been raised. Authentic communication of smoking with a series of symptoms bronchial asthma and chronic bronchitis in teenagers, shown is taped by a high and average parity of chances.

  1. RATIONALE FOR A SPECIFIC THERAPY OF CYTOMEGALOVIRUS INFECTION IN CHILDREN WITH BRONCHIAL ASTHMA

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    E. N. Suprun

    2013-01-01

    Full Text Available Abstract. We propose a protocol of treatment in cases of bronchial asthma with cytomegalovirus (CMV persistence. This basic therapy is administered depending on the disease severity, according to the National Programme 2009. The treatment includes administration of human immunoglobulin, with dosage according on CMV antibodies titers. The study has revealed that such regimen of antibody administration based on the content of anti-CMV antibodies in bronchial asthma treatment stops active CMV replication in bronchial mucous membrane, alleviates clinical course of the disease, diminishes changes of immune system typical to children suffering from bronchial asthma and CMV reactivation, thus allowing to reduce the volume of basic therapy, along with maintaining control of asthma control.

  2. Frequency of polymorphism -262 c/t in catalase gene and oxidative damage in Slovak children with bronchial asthma.

    Science.gov (United States)

    Babusikova, Eva; Jesenak, Milos; Evinova, Andrea; Banovcin, Peter; Dobrota, Dusan

    2013-12-01

    Bronchial asthma is a complex disease in which genetic factors, environmental factors and oxidative damage are responsible for the initiation and modulation of disease progression. If antioxidant mechanisms fail, reactive oxygen species damage the biomolecules followed by progression of the disease. Catalase is one of the most important endogenous enzymatic antioxidants. In the present study, we examined the hypothesis that increased oxidative damage and polymorphism in the CAT gene (-262 promoter region, C/T) are associated with childhood bronchial asthma. Genotyping of the polymorphisms in the CAT gene in healthy (249) and asthmatic children (248) was performed using polymerase chain reaction-restriction fragment length polymorphism. Markers of oxidative damage: content of sulfhydryl groups and thiobarbituric acid-reactive substances were determined by spectrophotometry in children. The TT genotype of catalase was more frequent among the asthmatic patients (22.6%) than in healthy children (4.8%) (odds ratio=5.63; 95% confidence interval=2.93-10.81, P<.001). The amount of sulfhydryl groups decreased significantly and conversely, the content of thiobarbituric acid-reactive substances increased significantly in bronchial asthma and in catalase TT genotype compared to other catalase genotypes of this gene. These results suggest that catalase polymorphism might participate in development of bronchial asthma and in enhanced oxidative damage in asthmatic children. Genetic variation of enzymatic antioxidants may modulate disease risk. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

  3. Association between bronchial asthma in atopic children and their number of siblings

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    Johan El Hakim Siregar

    2014-09-01

    Full Text Available Background The prevalence of asthma in children has increased in many countries. Environmental factors are believed to play an important role and an inverse relationship between number of siblings and atopic disorders has been observed. Objective To assess for an association between bronchial asthma in atopic children and their number of siblings. Methods A cross-sectional study was conducted from June to November 2010 in three elementary schools in Medan, North Sumatera. Trace cards from the Allergy-Immunology Indonesian Pediatric Association (IDAI Working Group and questionnaires on the clinical history of atopy were used to screen children with the risk of atopy. The International Study of Asthma and Allergies in Childhood (ISAAC questionnaire to screen for bronchial asthma was distributed to children aged 7-10 years with a history of asthma, allergic rhinitis or atopic dermatitis. Subjects were divided into two groups, those with <3 siblings and those with ≥3 siblings. Chi-square test was used to analyze differences in bronchial asthma prevalence between the two groups. Results Ninety-six subjects enrolled in the study, with 48 subjects per group. The prevalence of bronchial asthma was significantly higher in atopic children who had <3 siblings than in children with ≥3 siblings (73.5% and 26.5%, respectively; P=0.04. Conclusion Bronchial asthma was significantly more frequent in children with less than 3 siblings compared to those with 3 or more siblings. [Paediatr Indones. 2014;54:289-93.].

  4. Eosinophils in the bronchial mucosa in relation to methacholine dose-response curves in atopic asthma

    NARCIS (Netherlands)

    G.M. Moller (Trude); S.E. Overbeek (Shelley); C.G. van Helden-Meeuwsen; H.C. Hoogsteden (Henk); J.M. Bogaard (Jan)

    1999-01-01

    textabstractAsthma is characterized by both local infiltration of eosinophils in the bronchial mucosa and bronchial hyperreactivity (BHR). A detailed characterization of BHR implies analysis of a histamine or methacholine dose-response curve yielding not only the dose a

  5. Clinical and Immunological Features of Bronchial Asthma in Children on the Background of Persistent Intracellular Infections

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    O.Ye. Chernyshova

    2015-03-01

    Full Text Available The article presents information on the impact of persistent intracellular infections on the course of the di­sease and the state of immune system in children with bronchial asthma. Clinical features of bronchial asthma, the degree of sensitization, level of proinflammatory (IL-1, IL-2, IL-6, ­IL-8, IFN-α and IFN-γ, TNF-α and antiinflammatory (IL-4, ­IL-10 cytokines in the blood serum are described.

  6. Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

    OpenAIRE

    2010-01-01

    Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis,...

  7. Evaluation of serum l-carnitine level in children with acute bronchial asthma

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    Eman Ramadan

    2014-07-01

    Conclusion: According to our study, it could be concluded that l-carnitine decrease is linked to the occurrence of attack of bronchial asthma. Accordingly, it is recommended to make further studies to find out if there is a beneficial role of carnitine intake in the prophylaxis & treatment of attacks of bronchial asthma. The recommended studies should search for the most suitable dose & side effects of carnitine as a potential pharmaceutical agent.

  8. [Efficacy of combined relaxation exercises for children with bronchial asthma].

    Science.gov (United States)

    Gröller, B

    1991-05-01

    In the framework of a pilot study, 15 children having bronchial asthma (4 female, 11 male; age 5-11;6) participated, over a period of 8 weeks, in two weekly sessions of combined relaxation, respiratory and sports exercises. The present article in particular focuses on the relaxation exercises, made up of Progressive Muscle Relaxation and Autogenic Training elements as well as of phantasy travels, mantras, and periodic music. Ongoing observation of the children during training, the findings of subsequent semi-structured interviews with them, topical instances of coping with impending asthma attacks by using the techniques learned, as well as the results of a catamnestic inquiry some three years later--all indicate a positive impact of the relaxation exercises. Statistical analysis of the data at hand revealed significant improvements in a number of pulmonary function parameters (airway resistance, forced expiratory volume for 1 s, forced vital capacity, peak expiratory flow rate). Interpretation of these findings must however take into account the entirety of the training provided.

  9. [Effectiveness of combined relaxation exercises for children with bronchial asthma].

    Science.gov (United States)

    Gröller, B

    1992-02-01

    In the framework of a pilot study, 15 children having bronchial asthma (4 female, 11 male; age 5-11; 6) participated, over a period of 8 weeks, in two weekly sessions of combined relaxation, respiratory and sports exercises. The present article in particular focuses on the relaxation exercises, made up of Progressive Muscle Relaxation and Autogenic Training elements as well as of phantasy travels, mantras, and periodic music. Ongoing observation of the children during training, the findings of subsequent semi-structured interviews with them, topical instances of coping with impending asthma attacks by using the techniques learnt, as well as the result of a catamnestic inquiry some three years later--all indicate a positive impact of the relaxation exercises. Statistical analysis of the data at hand revealed significant improvements in a number of pulmonary function parameters (airway resistance, forced expiratory volume for 1 s, forced vital capacity, peak expiratory flow rate). Interpretation of these findings must however take into account the entirety of the training provided.

  10. [Oxidative stress in pathogenesis of bronchial asthma: a method of correction by inhalation of phospholipid nanoparticles].

    Science.gov (United States)

    Lisitsa, A V; Soodaeva, S K; Klimanov, I A; Aver'ianov, A V

    2014-01-01

    The authors present the results of a prospective simple blind randomized placebo-controlled study for the evaluation of dynamics of biomarkers of oxidative stress (total concentration of nitrate- and nitrite-anions in condensed exhaled breath and plasma, pH of exhaled breath, total antioxidative activity of plasma in patients with bronchial asthma inhaling phospholipid nanoparticles. The results suggest significant positive effect of proposed therapy on dynamics of the main parameters of oxidative stress including reduced concentration of nitric oxide metabolites and increased total antioxidative activity of plasma. No clinically significant reactions were documented.

  11. Bronchial hyperreactivity in non-atopic children with asthma and reflux: effect of anti-reflux treatment.

    Science.gov (United States)

    Khoshoo, Vikram; Mohnot, Sopan; Haydel, Robert; Saturno, Emilio; Edell, Dean; Kobernick, Aaron

    2009-11-01

    The prevalence of bronchial hyperreactivity (BHR) or the effect of anti-reflux treatment on BHR in children with asthma and gastroesophageal reflux disease (GERD) is not known. Thirty non-atopic children with persistent asthma were studied. Extended esophageal pH monitoring was used to diagnose GERD and methacholine challenge test (MCT) was used as a marker of BHR and performed before and 2 years after anti-GERD treatment. Of the 21 patients positive for GERD (group A), 15 had positive MCT suggesting BHR. Of the 9 patients negative for GERD (group B), 5 had positive MCT. On repeat testing 2 years later, 11/15 group A patients and 3/5 group B patients tested negative for BHR. Group A patients were receiving fewer asthma medications and experienced fewer exacerbations than Group B patients. BHR is prevalent in children with asthma and GERD and improves with anti-GERD treatment.

  12. May Inhaled Corticosteroid Use Give Rise to Impaired Glucose Tolerance in Bronchial Asthma?

    Directory of Open Access Journals (Sweden)

    Nurhan Köksal

    2005-01-01

    Full Text Available Systemic side effects of inhaler corticosteroids (IC are quite rarely. It is also well known that systemic use of corticosteroids for a long period of time may have diabetogenic effects. In this study, the relationship between use of IC in patients with bronchial asthma and tendency of development of diabetes was investigated via oral glucose tolerance test. Eighty three patients with bronchial asthma and 34 healthy subjects without any known disease as a control group were enrolled the study. Asthma group and control group were similar according to gender, age and BMI. Mean period for the diagnosis of asthma was 8.9±6.4 years, for IC use was 4.2±2.7 years and mean daily dose of IC was 616.66±355.62 µgr. Fasting blood glucose (FBG for asthma group who were on IC and for control group were 92.96±6.82 mg/dl and 93.05±12.51 mg/dl, respectively. Following 75 gr OGTT, glucose levels for asthma group and control group were 110.21±32.17 mg/dl and 109.08±28.41 mg/dl, respectively. FBG levels and 2-hour glucose levels separately in both groups were not statistically significant (p0.05. In asthma group, correlations between duration of IC use and, FBG and 2-hour glucose levels, and also between dose of IC and FBG and 2-hour glucose levels were evaluated. Statistically significant but mild positive correlation was seen between duration of IC (4.2±2.7 year use and 2-hour glucose levels (110.21±32.17 mg/dl (p=0.007, r=0.292. In conclusion, in patients with asthma, mild positive correlation between IC use and 2-hour glucose levels was observed. Our findings may point out that IC use over a long period of time may lead glucose intolerance.

  13. Effect of Vitamin C Administration on Leukocyte Vitamin C Level and Severity of Bronchial Asthma

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    Seyed Hamid Hashemi

    2012-04-01

    Full Text Available Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. Reactive oxygen species are released into the bronchial tree by activated inflammatory cells. In this study, we aimed to determine the effect of vitamin C administration on leukocyte vitamin C level as well as severity of asthma. In this double blind clinical trial study we evaluated 60 patients with chronic stable asthma. The patients were divided into two groups (A and B including 30 patients in each group. Patients in these groups were matched according to their age, weight, height, gender, BMI and drug consumption. In addition to standard asthma treatment (according to stepwise therapy in 4th step of bronchial asthma in which the patients were controlled appropriately, group A received 1000 mg vitamin C daily and group B received placebo. At the baseline and after one month treatment, non-fasting blood samples were drawn for laboratory evaluations. Asthmatic patient's clinical condition was evaluated through standard pulmonary function test (PFT. The mean (±SD leukocyte vitamin C level in group A at the baseline and after one month treatment with 1000 mg/day vitamin C, were 0.0903 (±0.0787 µg/108 leukocytes and 0.1400 (±0.0953 µg/108 leukocytes respectively (P<0.05. The mean (±SD leukocyte vitamin C level in group B at the baseline and after one month administration of placebo, were 0.0867 (±0.0629 µg/108 leukocytes and 0.0805(±0.0736 µg/108 leukocytes respectively. The leukocyte vitamin C level in group A was higher than those of group B after one month treatment with vitamin C and placebo and the difference was statistically significant (P<0.05. Comparing PFT (FEV1, FVC and FEV1/FVC in group B during the study period showed a significant increase in FEV1 (P<0.05, while the other two parameters remained unchanged. In group A, who received 1000 mg/day vitamin C, none of the spirometry parameters changed after

  14. Role of health education and self-action plan in improving the drug compliance in bronchial asthma

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    Gajanan S Gaude

    2014-01-01

    Full Text Available Background: Considering the prevalence and associated burden of disease due to bronchial asthma, it is mandatory to obtain an optimal control of the disease and to improve outcomes for these patients. But it has been observed that there is very poor adherence to the inhalational therapy which leads to the suboptimal control of the disease. Objectives of the Study: To study the adherence for aerosol therapy in bronchial asthma patients and to assess the impact of health education and self-action plan in improving the compliance to the therapy. Methodology: A prospective study was done in a total of 500 bronchial asthma patients over a period of 2 years. Once included in the study, the patients were followed-up for a total of 12 weeks for calculation of nonadherence to the aerosol therapy. In nonadherent patients, we employed various health education strategies to improve the compliance in these cases. Results: A total of 500 patients of bronchial asthma who were started on aerosol therapy over duration of 2 years were included in the study. At the end of 12 weeks, it was observed that, only 193 patients (38.6% had regular compliance and 307 patients (61.4% were noncompliant to aerosol therapy as prescribed for bronchial asthma. Factors that were associated with poor compliance were: Lower educational level status, poor socioeconomic status, cumbersome regimens, dislike of medication, and distant pharmacies. Nondrug factors that reduced the compliance were: Fears about side effects, anger about condition or its treatment, forgetfulness or complacency, and patient′s ill attitudes toward health. After employing the various strategies for improving the compliance in these patients, the compliance increased in 176 patients (57.3% among the earlier defaulted patients, while the remaining 131 patients (42.7% were found to be noncompliant even after various educational techniques. Conclusion: Noncompliance in asthma management is a fact of life and no

  15. Peculiarities of cardiac performance in children with bronchial asthma against chronic tonsillitis

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    Kondratiev V.А.

    2015-11-01

    Full Text Available A comparative assessment of cardiac performance by the data of clinical-instrumental examination of 50 patients aged 5-15 years with persisting form of partially-controlled atopic bronchial asthma in the period between the attacks of the disease was made. Children were divided into two groups depending on presence of concomitant chronic tonsillitis (18 patients or absence of the latter (32 patients. In all cases by the data of spirography in children against chronic tonsillitis in the period between the attacks of the disease there were revealed ventillation disorders in the lungs by obstruction type, this promoted elevation of pressure in the pulmonary artery. Only in this group of patients in 27,8% of cases pulmonary arterial hypertension of moderate severity was revealed. By echocardiography data in children with asthma against chronic tonsillitis reliably more often (р<0,01 there was revealed decrease of contractile function of myocardium of the left cardiac ventricle; this was caused by the presence of metabolic disturbances in the myocardium in the majority of cases (83,3%. These changes were registered on the electrocardiogram in the form of repolarisation changes of the ventricular complex. Presence of concomitant chronic tonsillitis in children with bronchial asthma favored formation of pulmonary hypertension on the one side and worsening of contractile ability of myocardium of the left cardiac ventricle on the other side; this required performing therapeutic-preventive measures for sanation of chronic infectious focus in the nasopharynx to prevent formation of chronic cardiac insufficiency during asthma course.

  16. Interventional pulmonology for asthma and emphysema: bronchial thermoplasty and bronchoscopic lung volume reduction.

    Science.gov (United States)

    Miller, Russell J; Murgu, Septimiu D

    2014-12-01

    Emphysema and asthma are responsible for economic and social burden. Altering the natural course of these diseases is a field of intense research. The National Emphysema Treatment Trial showed that lung volume reduction surgery (LVRS) could significantly reduce both morbidity and mortality in properly selected patients. LVRS is seldom performed, however, due to the high morbidity associated with the surgery. Numerous bronchoscopic interventions have been introduced with the goal of providing the clinical benefits of LVRS without the surgical complications. Thus far, these modalities have not produced the results once hoped. However, through active modification of both technique and patient selection, the role of minimally invasive modalities in the treatment of emphysema continues to evolve. Bronchial thermoplasty (BT) is a method of delivering controlled heat to airway mucosa with the goal of reducing airway smooth muscle mass and hence bronchoconstriction. In patients suffering from asthma who cannot achieve control with standard medical care, BT has been shown to be safe and improves symptoms, with long lasting benefit. BT does not seem to affect traditional markers of asthma severity such as forced expiratory volume in 1 second and questions remain regarding proper patient selection for this therapy and its true physiologic effects. This article is a review of bronchoscopic modalities for emphysema and asthma.

  17. Chemiluminescence of neutrophiles stimulated by opsonized Zymosan in children with bronchial asthma and pneumonia

    Science.gov (United States)

    Lewandowicz-Uszynska, A.; Jankowski, A.

    2004-08-01

    Oxygen metabolism of neutrophils after stimulation with opsonized zymosan was examined using chemiluminescence test (in the presence of the patient serum or pooled serum). Into the study 37 children aged from 2 to 12 years were enrolled (20 girls and 17 boys). 10 healthy volunteers comprised the control group (group III). Two groups of patients were established: group I -- children with bronchial asthma (without infection), group II -- children with pneumonia. The examination in both groups was performed twice -- in acute phase and in remission period. The group I in acute phase comprised 16 children and in remission phase 9 children, group II - 21 children in acute phase and 9 children in remission phase, respectively. The following parameters of CL were estimated average value of so called spontaneous CL, maximal excitation of neutrophils after stimulation by zymogen (CLmax), time of zymosan opsonization. The following results were obtained: increased spontaneous CL and CLmax (at the presence of both sera) in acute phase of bronchial asthma and pneumonia in comparison to the control group. In the period of remission both these parameters were insignificantly decreased. The longest time of zymosan opsonization in acute period of disease was observed in children with pneumonia (18 min.). This time did not change during remission phase. Only slightly longer time of opsonization was observed in the patients from group I (in exacerbation) (15 min) than in the control group (13,1 min). This time was prolonged in the clinical remission (20 min).

  18. Clinical Observation on Prevention of Bronchial Asthma with Plaster on Acupoints

    Institute of Scientific and Technical Information of China (English)

    YU Jin-long; ZHU Han-ting

    2008-01-01

    @@ Bronchial asthma is a most common and chronicillness which often relapses and has no cure at present.Acupuncture has its specific advantage in treatingasthma. The author prevented 29 cases of asthma innon-acute stage of attack with plaster on acupoints.Now it is reported as follows.

  19. Challenges in the Management of Bronchial Asthma Among Adults ...

    African Journals Online (AJOL)

    to be relevant for inclusion in the review was retrieved. .... education of patients by the health‑care providers to enable the ..... Policy 2011;99:250‑4. 12. ... Practice of asthma management among doctors in south‑east ... hospital in Malaysia.

  20. Treating chronic persistent bronchial asthma children with abnormal myocardial enzyme spectrum by Yupingfeng powder: an efficacy observation

    Institute of Scientific and Technical Information of China (English)

    陈啸洪

    2014-01-01

    Objective To observe the clinical efficacy of treating chronic persistent bronchial asthma(CPBA)children with abnormal myocardial enzyme spectrum(AMES)by Yupingfeng Powder(YP)combined with routine therapy.Methods From January 2010 to December 2012,156CPBA children patients with AMES were randomly assigned to the treatment group(80 cases)and the control group(76 cases).All patients received routine treatment(inhaled corticosteroids and/or leukotriene regulator).

  1. ASSESSMENT OF EFFICACY OF LEUKOTRIENE RECEPTOR ANTAGONISTS IN THERAPY OF BRONCHIAL ASTHMA IN CHILDREN

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    Yu.G. Levina

    2009-01-01

    Full Text Available The article provides data regarding the clinical efficacy and safety of leukotriene receptor antagonists in treatment of bronchial asthma in children. The only representative of this group that is allowed in Russia for treatment of children over 6 years of age is Montelukast. Approval of new 4 mg dosage of Montelukast for children from 2 years of age is expected in Russia in July 2009. Leukotriene receptor antagonists have a high safety profile and can be used as an alternative first-line therapy for persistent asthma.Key words: leukotriene receptor antagonists, montelukast, bronchial asthma, children.

  2. The usage of sustained-action theophyline in the intercrisis treatment of bronchial asthma.

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    Yaquelín Martínez Chavez.

    2004-04-01

    Full Text Available Fundaments: Bronchial Asthma is a chronic inflammatory disease of the air ways. Theophylline is recommended in its treatment because of its probable anti-inflamatory effect. Due to this reason, the clinical effect of sustained action theophylline (TEOCEN 200mg is assessed in the intercrisis of Bronchial Asthma. Method : 40 moderate and severe asthmatic patients received treatment with a 9 mg/kg/day dose every 12 hours (q.12, at the outpatient consultation of the University Hospital Celestino Hdez¨ of Villa Clara, from September 2002 to June 2003. Treatment lasted a month, period in which had 5 visits to the doctor. The variables under study in each visit were: attendance to the emergency department, use of salbutamol spray and objective measurement of lung function as well as adverse effects and response to treament. Wilconxon, Cochron Q and Mc. Nemor´s non-parametric tests were used in this study. Significant difference was considered as p< 0, 05, highly significant difference as p< 0,01. Results : The use of salbutamol spray and the need to go to the emergency department diminished significantly meanwhile the peak expiratory flux, the forced expiratory volume in one second, the maximum expiratory medium flux and the forced expiratory volume in one second post salbutamol application increased significantly. There was a low incidence of adverse effects. Conclusion : The formula was useful and is recommended in the control of the symptoms of moderate and severe asthmatic patients in the intercrisis period.

  3. The Monitoring Features Under Eosinophilic Phenotype of Bronchial Asthma Among the Children

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    Tatiana Bilous

    2015-09-01

    Full Text Available Abstract Purpose: to study features of monitoring in the dynamics of the basic treatment of eosinophilic phenotype of asthma in school-age children. Materials and methods. Surveyed 88 school-age children with bronchial asthma. The first group included 45 patients who met eosinophilic phenotype (EFBA and group II formed the 43 patients with evidence of neutrophilic phenotype (NFBA. Results and discussion. It should be noted that if the early inflammatory therapy destination exchange only 10.5% of the patients disease was defined as EFBA controlled and the finishing treatment increased the proportion of cases of controlled to 25.6% (Pφ>0,05 and in the second clinical group – at 22.3% of 50.0% patients, Pφ<0,05. Also marked anti-inflammatory effect in both groups in exhaled breath condensate and increase in the lability of the bronchi occurred in 39.1% of children with EFBA, and 60.0% of the representatives of the comparison group. Conclusions. Thus, in patients with signs of eosinophilic phenotype compared with children with neutrophilic airway inflammation markers hyperresponsiveness and inflammation of the bronchi more expressive as the lability of the respiratory tract. Under the influence of the basic anti-inflammatory treatment in patients with eosinophilic asthma phenotype is a reduction of inflammation of the bronchi, but not lability and hyperresponsiveness.

  4. RELATIONSHIP BETWEEN PSYCHOPATHOLOGY & SOCIO-DEMOGRAPHIC AND CLINICAL VARIABLES IN COPD AND BRONCHIAL ASTHMA: A COMPARATIVE STUDY

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    Mayank

    2014-11-01

    Full Text Available This is a cross sectional comparative case control study assessing the Relationship between psychopathology and socio demographic and clinical variables in chronic obstructive pulmonary disease (COPD and Bronchial Asthma in comparison to healthy individuals. The investigation reveals that there is psychopathology in all the three groups. The psychopathology is significantly more in patients with COPD. Psychopathology in COPD patients is related to age, duration, severity of illness and steroid medication. It is found that psychopathology in bronchial asthma patients are more than those of healthy controls but there is no significant difference. The psychopathology is significantly related to relate to age, marital status, occupational status, and smoking. Duration severity of illness and steroid medication.

  5. Airway Smooth Muscle as a Target in Asthma and the Beneficial Effects of Bronchial Thermoplasty

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    Luke J. Janssen

    2012-01-01

    Full Text Available Airflow within the airways is determined directly by the lumenal area of that airway. In this paper, we consider several factors which can reduce airway lumenal area, including thickening and/or active constriction of the airway smooth muscle (ASM. The latter cell type can also contribute in part to inflammation, another feature of asthma, through its ability to take on a synthetic/secretory phenotype. The ASM therefore becomes a strategically important target in the treatment of asthma, given these key contributions to the pathophysiology of that disease. Pharmacological approaches have been developed to elicit relaxation of the ASM, but these are not always effective in all patients, nor do they address the long-term structural changes which impinge on the airway lumen. The recent discovery that thermal energy can be used to ablate smooth muscle has led to the development of a novel physical intervention—bronchial thermoplasty—in the treatment of asthma. Here, we review the evolution of this novel approach, consider some of the possible mechanisms that account for its salutary effects, and pose new questions which may lead to even better therapies for asthma.

  6. Nebulized magnesium sulphate versus nebulized salbutamol in acute bronchial asthma

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    E.A. Abdelnabi

    2012-07-01

    Conclusion: The use of MgSO4 by nebulization in patients with acute asthma attacks results in improvement of clinical condition, increase in peak expiratory flow rate (PEFR, reduction in heart rate (HR, reduction in respiratory rate (RR and improvement in oxygen saturation (SO2. The increase in PEFR (bronchodilatory effect was significantly less than that achieved in patients receiving the usual treatment with Short acting β2 agonists, e.g. salbutamol, when either agents were used alone.

  7. Pneumorrhachis, pneumomediastinum, pneumopericardium and subcutaneous emphysema as complications of bronchial asthma

    Directory of Open Access Journals (Sweden)

    Manden Prasad

    2009-01-01

    Full Text Available Pneumorrhachis (PR, or epidural emphysema, denotes the presence of air in the spinal epidural space. It can be associated with a variety of etiologies, including trauma; recent iatrogenic manipulations during surgical, anesthesiological and diagnostic interventions; malignancy and its associated therapy. It usually represents an asymptomatic epiphenomenon but also can be symptomatic by itself as well as by its underlying pathology. The pathogenesis and etiology of PR are varied and can sometimes be a diagnostic challenge. As such, there are no standard guidelines for the management of symptomatic PR, and its treatment is often individualized. Frequently, multidisciplinary approach and regimes are required for its management. PR associated with bronchial asthma is extremely rare, and only very few cases are reported in the literature. Here, we report a case of a 17-year-old Saudi male patient who is a known case of bronchial asthma; he presented with extensive subcutaneous emphysema, pneumomediastinum, pneumopericardium and pneumorrhachis as complications of an acute exacerbation of his primary ailment.

  8. The possibility of evaluation on inflammatory change at respiratory tract in chronic bronchial asthma using {sup 67}Ga scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Fukumitsu, Nobuyoshi; Uchiyama, Mayuki; Mori, Yutaka; Kawakami, Kenji [Jikei Univ., Tokyo (Japan). School of Medicine; Kikuchi, Ichiro; Shimada, Takao

    1997-05-01

    {sup 67}Ga scintigraphy was performed in 17 patients with chronic bronchial asthma to grasp the inflammatory change of respiratory tract. On {sup 67}Ga scintigraphy, abnormal accumulations were detected on lung fields in 6 cases (35.3%) of 17 cases. In 5 cases of these 6 cases, the defect areas which were pointed out on {sup 81m}Kr ventilation scintigraphy were matched to the abnormal accumulation areas which were pointed out on {sup 67}Ga scintigraphy. In dynamics, the abnormal accumulation areas which were pointed out on {sup 67}Ga scintigraphy were matched to the defect areas which had been at all times pointed out on {sup 81m}Kr ventilation scintigraphy. {sup 67}Ga scintigraphy was expected to be one of index to grasp the inflammatory change of respiratory tract in patients with chronic bronchial asthma. (author)

  9. HRCT and bronchial asthma: visualization of the pathophysiologic changes of the pulmonary parenchyma after inhalation provocation; HRCT und Asthma bronchiale: Visualisierung pathophysiologischer Veraenderungen des Lungenparenchyms nach inhalativer Provokation

    Energy Technology Data Exchange (ETDEWEB)

    Schueller, G.; Neumann, K.; Helbich, T.; Herold, C.J. [Univ. Klinik fuer Radiodiagnostik, Abt. fuer konservative Faecher, Vienna (Austria); Riemer, H. [Univ. Klinik fuer Innere Medizin IV, Abt. fuer Pulmologie, Vienna (Austria); Backfrieder, W. [Allgemeines Krankenhaus, Vienna (Austria). Inst. fuer Biomedizinische Technik und Physik; Sertl, K. [Krankenhaus der Stadt Wien-Floridsdorf (Austria). Abt. fuer Innere Medizin; Pittner, B. [Vienna Univ. (Austria). Inst. fuer Medizinische Statistik

    2004-03-01

    Purpose: To characterize parenchymal lung affections morphologically in patients with asthma and healthy subjects by high resolution computed tomography (HRCT) subsequent to histamine-triggered inhalation bronchoprovocation and salbutamolinduced broncholysis, and to compare the results with pulmonary function tests. Materials and Methods: Fifteen asthmatics with bronchial hyperreactivity, with a>20% decrease in FEV1 and a>10 mmHg decrease in PaO{sub 2} after bronchoprovocation (PC20%+), twelve asthmatics with a<20% decrease in FEV1 and a>10 mmHg decrease in PaO{sub 2} after bronchoprovocation (PC20%-), and eight healthy persons without bronchial hyperreactivity underwent inhalation bronchoprovocation and broncholysis. Spirometer-triggered HRCT at high lung volumes was performed, and total and peripheral lung densities and the amount of solid lung structures, representing predominantly vessels, were measured. Results: After bronchoprovocation, we observed significant decreases in total and peripheral lung densities in all groups (p<0.0005), and a significant increase in lung densities subsequent to bronchodilation (p<0.0002). The morphological alterations in solid lung structure were not significantly different after bronchoprovocation or broncholysis (p>0.05), as compared to the baseline measurements. In hyperreactive patients, PaO{sub 2} significantly decreased after provocation and significantly increased after lysis (p<0.05). In PC20%+ asthmatics, a mean reduction of 27.8% in FEV1 was observed, which was <20% in the other groups. No significant correlations were observed between radiological data and the results of pulmonary function tests. In healthy persons, we demonstrated highly significant parenchymal response to bronchoprovocation and broncholysis, which was not otherwise documented by pulmonary function tests. Conclusion: In both PC20%+ and PC20%- patients as well as in healthy individuals, HRCT was efficient in the evaluation of pathoanatomical

  10. 1例支气管舒张剂不耐受支气管哮喘患者的药学监护%Pharmaceutical care on a bronchodilator intolerance patient with bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    张莉; 舒鹤; 王哲; 李冰; 段小菊

    2015-01-01

    One 74-year-old female patient with acute bronchial asthma, who narrated she was allergic to aminophylline, complained of palpitation after administration of budesonide, terbutaline and ipratropium bromide for diastole bronchus, relieving asthma, anti-infection therapy. The asthma symptom of the patient didn't improve even combination use of intravenous drip of glucocorticoids. Clinical pharmacist assisted with physicians to analyze the cause of intolerance to terbutaline and ipratropium bromide and denied that the patient was allergic to aminophylline. The therapeutic schedules were adjusted, after 25-day therapy, asthma of the patient was controlled, and the patient was discharged. Clinical pharmacists played an important role in the pharmaceutical care on the evaluation of therapeutic regimen, usage of off-label, repeated drug use, etc.%1例74岁女性支气管哮喘急性发作患者,自述对氨茶碱过敏。入院后给予布地奈德、特布他林、异丙托溴铵舒张支气管、平喘、抗炎治疗,患者心悸不能耐受,加用糖皮质激素静脉滴注治疗后哮喘症状仍未明显缓解。临床药师协助医生分析患者对特布他林、异丙托溴铵心悸不能耐受的原因,并经仔细问诊排除氨茶碱过敏,调整治疗方案后哮喘症状得到控制,治疗25 d患者病情好转出院。此次治疗中,药师协助医生制定评估治疗方案,并在药物的超说明书用法、重复用药等方面给予药学监护。

  11. [EVALUETION OF THE CLINICAL EFFICACY OF SUSTAINED RELEASE THEOPHILLINE IN A COMPLEX BASIC THERAPY OF EOSINOPHILIC PHENOTYPE OF BRONCHIAL ASTHMA IN SCHOOL AGE CHILDREN].

    Science.gov (United States)

    Ortemenka, Ye P

    2014-01-01

    Based on a complex examination of 11 school age children with eosinophilic phenotype of bronchial asthma, it has been demonstrated that combination of inhaled corticosteroids with oral sustained release theophillines were more effective as a basic anti-inflammatory asthma therapy, in comparison with monotherapy by inhaled corticosteroids. The usage of such combined anti-relapsing asthma treatment has been reduced both the relative risk (RR = 57%) and the attributable risk (AR = 36.3%) of insufficient control of bronchial asthma in children with eosinophilic type of airways inflammation. At the same time, the minimum number of patients, which have to be treated by such method with the object of preventing at least one case of poor asthma control, came to 3 children.

  12. 支气管哮喘合并支气管扩张患者临床特点及治疗方法分析%The analysis of clinical characteristics and treatment methods about patients with bronchial asthma complicated with bronchiectasis

    Institute of Scientific and Technical Information of China (English)

    王勇; 何权瀛

    2016-01-01

    Objective To explore clinical characteristics and treatment methods of patients with bronchial asthma complicated with bronchiectasis.Methods 62 patients with asthma complicated with bronchiectasis were selected.Medical history,symptoms,signs,auxiliary examination and treatment methods were extracted from medical records of patients to carry on a summary analysis.Results Clinical characteristics of patients with bronchial asthma complicate with bronchiectasis were as follows:The frequency of personal allergic and family history of asthma was high.Clinical symptoms always showed the overlap symptoms of asthma and bronchiectasis and were atypical.Most patients had obviously seasonal regularity and attack frequency and hospitalization rate were high.The control of asthma symptoms was difficult.Bronchiectasis regions were not obviously regular on chest HRCT.The positive rate of bronchial provocation test was significantly higher than that of the bronchial dilation test.Positive rate of bacterial culture of sputum was not high.All patients were adopted comprehensive treatment measures of anti-asthma and anti-bronchiectasis and achieved good therapeutic effect.Conclusion Bronchial asthma complicated with bronchiectasis is a special clinical type,which can be differentiate from pure bronchiectasis or pure asthma by the clinical features,bronchial provocation tests,bronchial dilation test and chest HRCT. Comprehensive treatment measures of anti-asthma and anti-bronchiectasis are recommended.%目的:探讨支气管哮喘(简称哮喘)合并支气管扩张(简称支扩)的临床特点及治疗方法。方法选取62例哮喘合并支扩的住院患者,从病历中收集患者的病史、症状、体征、辅助检查、治疗方法等资料进行总结分析。结果(1)哮喘合并支扩患者临床特点为:①多有个人过敏性疾病史和哮喘家族史,症状多表现为哮喘和支扩症状的叠加,体征不典型,有明

  13. Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma.

    Science.gov (United States)

    Smolensky, Michael H; Lemmer, Bjoern; Reinberg, Alain E

    2007-08-31

    Study of the chronobiology of allergic rhinitis (AR) and bronchial asthma (BA) and the chronopharmacology and chronotherapy of the medications used in their treatment began five decades ago. AR is an inflammatory disease of the upper airway tissue with hypersensitivity to specific environmental antigens, resulting in further local inflammation, vasomotor changes, and mucus hypersecretion. Symptoms include sneezing, nasal congestion, and runny and itchy nose. Approximately 25% of children and 40% of adults in USA are affected by AR during one or more seasons of the year. The manifestation and severity of AR symptoms exhibit prominent 24-h variation; in most persons they are worse overnight or early in the morning and often comprise nighttime sleep, resulting in poor daytime quality of life, compromised school and work performance, and irritability and moodiness. BA is also an inflammatory medical condition of the lower airways characterized by hypersensitivity to specific environmental antigens, resulting in greater local inflammation as well as bronchoconstriction, vasomotor change, and mucus hypersecretion. In USA an estimated 6.5 million children and 15.7 million adults have BA. The onset and worsening of BA are signaled by chest wheeze and/or croupy cough and difficult and labored breathing. Like AR, BA is primarily a nighttime medical condition. AR is treated with H1-antagonist, decongestant, and anti-inflammatory (glucocorticoid and leukotriene receptor antagonist and modifier) medications. Only H1-antagonist AR medications have been studied for their chronopharmacology and potential chronotherapy. BA is treated with some of the same medications and also theophylline and beta2-agonists. The chronopharmacology and chronotherapy of many classes of BA medications have been explored. This article reviews the rather extensive knowledge of the chronobiology of AR and BA and the chronopharmacology and chronotherapy of the various medications used in their treatment.

  14. An epidemiology study of bronchial asthma in the Li ethnic group in China.

    Science.gov (United States)

    Ding, Yi-Peng; Yao, Hong-Xia; Tang, Xiao-Lan; He, Hai-Wu; Shi, Hui-Fang; Lin, Li; Li, Min; Chen, Shan; Chen, Jing; Wang, Hai-Jiao

    2012-02-01

    To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan, China. This study employed a stratified random sample design using custom-designed questionnaires. Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test, bronchial dilation test and challenge test. Demographic data, information on family history of asthma, history of allergies, smoking habits, domestic cooking fuel and other potential risk factors were collected. Logistic regression was performed to evaluate risk factors for asthma. The prevalence of asthma in the Li ethnic group was 3.38%, much higher than the national average level in China. Aging, agriculture industry (the rubber industry in particular), rural residence, family history of asthma, history of allergies, cold air, inhalation of dust and irritant gases, smoking, domestic cooking fuel and living environment were associated with increased risk of asthma. The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population. Risk factors indentified in this study warrant special attention. Elevating public awareness about asthma in local communities will benefit the prevention of the disease. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  15. Bronchial asthma in elderlies: an approach to this issue in Cuba

    Directory of Open Access Journals (Sweden)

    Marisela Pérez Pacaréu

    2011-03-01

    Full Text Available Clinical and epidemiological behaviour of bronchial asthma in elderlies is almost an unknown topic in the investigations carried out in the field, because studies conducted in adult population approach a single age group from 15 years old on. Bronchial asthma is considered a health problem given its high prevalence: about 10% of the Cuban population suffers from it. In elderlies it is an underdiagnosed and undertreated disease often confused with chronic lung disease, so it is very important to able to evaluate the specific characteristics it presents in elderlies in order to attack the disease effectively, and promote the life quality of asthmatic elderlies.

  16. Toxocara canis y asma bronquial Toxocara canis and bronchial asthma

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    María de los Ángeles López

    2010-02-01

    symptoms of grade I there was a 37.5% (p = 0.0470. The infection with T. canis could act as a co-factor increasing the severity of the symptoms of bronchial asthma.

  17. Common variable immunodeficiency diagnosed during the treatment of bronchial asthma: Unusual cause of wheezing

    Science.gov (United States)

    Akaba, Tomohiro; Kondo, Mitsuko; Toriyama, Midori; Kubo, Ayako; Hara, Kaori; Yamada, Takeshi; Yoshinaga, Kentaro; Tamaoki, Jun

    2015-01-01

    Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency in adults and children. We herein report a case of CVID, who was misdiagnosed with asthma due to wheezing episodes and relatively late onset. A 51-year-old woman had suffered from recurrent upper and lower airway infection for recent 2 years. She repeated wheezing attacks and was treated as asthma exacerbation triggered by infection. She was referred to our hospital for investigation and treatment. Lung function tests showed no reversibility of FEV1 by β-adrenergic agonist, but the increase of V50/V25. Chest CT showed slight to moderate bronchial wall thickening and bronchiectasis. After that, she suffered from pneumonia with wheezing attacks twice a month, and immunodeficiency was strongly suspected. Her blood tests showed marked decreases of all classes of immunoglobulin and nearly lack of memory B cells, NKT cells and plasmacytoid dendritic cells. She was diagnosed with CVID, and was treated with replacement of gammaglobulin. Thereafter, her wheezing episodes with infection were remarkably improved. Because the delay of diagnosis with CVID likely causes poor mortality and morbidity, a possibility of CVID should be considered in patients with frequent asthma-like symptoms due to recurrent airway infection. PMID:26744651

  18. Common variable immunodeficiency diagnosed during the treatment of bronchial asthma: Unusual cause of wheezing

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    Tomohiro Akaba

    2015-01-01

    Full Text Available Common variable immunodeficiency (CVID is the most frequent primary immunodeficiency in adults and children. We herein report a case of CVID, who was misdiagnosed with asthma due to wheezing episodes and relatively late onset. A 51-year-old woman had suffered from recurrent upper and lower airway infection for recent 2 years. She repeated wheezing attacks and was treated as asthma exacerbation triggered by infection. She was referred to our hospital for investigation and treatment. Lung function tests showed no reversibility of FEV1 by β-adrenergic agonist, but the increase of V50/V25. Chest CT showed slight to moderate bronchial wall thickening and bronchiectasis. After that, she suffered from pneumonia with wheezing attacks twice a month, and immunodeficiency was strongly suspected. Her blood tests showed marked decreases of all classes of immunoglobulin and nearly lack of memory B cells, NKT cells and plasmacytoid dendritic cells. She was diagnosed with CVID, and was treated with replacement of gammaglobulin. Thereafter, her wheezing episodes with infection were remarkably improved. Because the delay of diagnosis with CVID likely causes poor mortality and morbidity, a possibility of CVID should be considered in patients with frequent asthma-like symptoms due to recurrent airway infection.

  19. 肥胖型支气管哮喘患者合并阻塞性睡眠呼吸暂停综合征临床分析%Clinical analysis of obese bronchial asthma patients with obstructive sleep apnea syndrome

    Institute of Scientific and Technical Information of China (English)

    蔡志明; 刘建南; 陈理达; 柯瑟章

    2016-01-01

    目的:本研究初步探讨了肥胖型支气管哮喘患者合并阻塞性睡眠呼吸暂停低通气综合征( OS-AHS)的临床特点。方法评价95例诊断为肥胖型支气管哮喘患者的年龄、性别、睡眠打鼾史、高血压史、吸烟史、饮酒史、动脉血压。使用多导睡眠监测系统记录睡眠过程中的多次生理事件,评价AHI和最低血氧饱和度( SaO2),使用哮喘控制测试问卷( ACT)评估哮喘控制情况。结果肥胖型支气管哮喘患者48.4%合并有阻塞性睡眠呼吸暂停,肥胖型支气管哮喘合并阻塞性睡眠呼吸暂停组与单纯哮喘组对比,肺通气功能更差、哮喘控制率更低。结论肥胖型支气管哮喘患者易合并阻塞性睡眠呼吸暂停,导致哮喘不易控制。%Objective To investigate the clinical features of obese bronchial asthma patients with obstructive sleep apnea syndrome. Methods Their age, gender, blood pressure, and history of sleep symptoms, hypertension, smoking and alcohol consumption of 95 obese patients with bronchial asthma were recorded. All patients underwent polysomnography. Apnea-hypopnea index ( AHI) and lowest O2 ( SaO2 ) saturation were calculated. ACT score was used to assess the control of asthma. Results 48. 4% of obese patients with bronchial asthma were diagnosed with obstructive sleep apnea. Patients with OSAHS and asthma showed worse lung function and low asthma control rate compared with that without OSAHS. Conclusion High prevalence of obstructive sleep apnea is observed in obese patients with bronchial asthma, which Results in therapy failure.

  20. Long-term (5 year safety of bronchial thermoplasty: Asthma Intervention Research (AIR trial

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    Pavord Ian D

    2011-02-01

    Full Text Available Abstract Background Bronchial thermoplasty (BT is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure. Methods Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta2-agonists and demonstrated worsening of asthma on long-acting-β2-agonist withdrawal. Following initial evaluation at 1 year, subjects were invited to participate in a 4 year safety study. Adverse events (AEs and spirometry data were used to assess long-term safety out to 5 years post-BT. Results 45 of 52 treated and 24 of 49 control group subjects participated in long-term follow-up of 5 years and 3 years respectively. The rate of respiratory adverse events (AEs/subject was stable in years 2 to 5 following BT (1.2, 1.3, 1.2, and 1.1, respectively,. There was no increase in hospitalizations or emergency room visits for respiratory symptoms in Years 2, 3, 4, and 5 compared to Year 1. The FVC and FEV1 values showed no deterioration over the 5 year period in the BT group. Similar results were obtained for the Control group. Conclusions The absence of clinical complications (based on AE reporting and the maintenance of stable lung function (no deterioration of FVC and FEV1 over a 5-year period post-BT in this group of patients with moderate to severe asthma support the long-term safety of the procedure out to 5 years.

  1. Benefits and risks of the subcutaneous immunotherapy with acari extracts in allergic rhinoconjunctivitis and bronchial asthma

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    Olimpio Rodríguez-Santos

    2014-12-01

    Full Text Available The records of patients from the Allergology Service in the Previsora Policlinic, Camagüey were revised to evaluate benefits and risks of the subcutaneous immunotherapy (ITSC with extracts of acari. The study was observational, analytic and retrospective of cases and controls in allergic rhinoconjunctivitis and bronchial asthma. A total of 160 subjects, older than 18 years old, were chosen. Eighty out of them had already received ITSC with dose increase during 13 weeks and maintenance with monthly injections during 18 months. A total of 80 patients who only received prevention measures and medications during the crises were paired. Questionnaires were applied for quality of rhinoconjunctivitis life and asthma, about the consumption of medications and the frequency of the crises. The adverse events were measured, as they were local and systemic to the cutaneous tests, to the ITSC and the different pharmacological treatments. There was a significant increase of the punctuation of life quality questionnaires, (p=0.011. The consumption of medications decreased in both the cases and the controls, without significant differences (p=0.083. The frequency of the rhinitis and asthma crises decrease in the group of ITSC (p=0.029. Slight local and systemic reactions were reported in both groups with Odds ratio (OR=2.029 in the ITSC group, with a 95% confidence interval of 1.114–3.967 (p=0.019. The results show that the subcutaneous immunotherapy with acari offers benefits and few risks to patients with allergic rhinoconjunctivitis and asthma.

  2. Radioaerosol inhalation lung scintigraphy in bronchial asthma; Deposition patterns of radioaerosol and mucocilliary clearance in children and youth

    Energy Technology Data Exchange (ETDEWEB)

    Chiba, Takashi (Nippon Medical School, Tokyo (Japan))

    1993-06-01

    A study on obstructive changes in airways and mucociliary clearance in children and youth with bronchial asthma was performed. Radioaerosol inhalation lung scintigraphies using [sup 99T]c-human serum albumin (HSA) were applied to 50 children and youth with bronchial asthma. The deposition patterns of the radioaerosol and aerosol clearance curves were evaluated. Abnormal deposition patterns, which consisted of non-homogeneous distribution and/or hot spot formation, were likely to be seen in patients with asthmatic attacks at the time of measurements. However, a few asymptomatic patients also revealed abnormal deposition patterns. The deposition patterns were related to FEV[sub 1.0]%, MMF, V[sub 50] and V[sub 25], but especially to FEV[sub 1.0]%. As an index of mucociliary clearance, [beta], the rate constant of the [sup 99m]Tc-HSA aerosol clearance curve, was introduced. [beta] was significantly lower in patients with abnormal aerosol deposition patterns than in normal persons. [beta] was also significantly lower in patients undergoing asthmatic attack at the time of the measurements than in asymptomatic patients. [beta] correlated negatively with FEV[sub 1.0]%, MMF, V[sub 50] and V[sub 25], but especially with FEV[sub 1.0]%. Although patients with long term affection or moderate-to-severe asthma tended to reveal abnormal deposition patterns and had low [beta] values, these differences were not statistically significant. Radioaerosol inhalation lung scintigraphy with [sup 99m]Tc-HSA is useful for evaluating not only obstructive changes in the airways but also for evaluating mucociliary clearance in children with bronchial asthma. (author).

  3. Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization

    DEFF Research Database (Denmark)

    Vinding, Rebecca K; Stokholm, Jakob; Chawes, Bo Lund Krogsgaard

    2016-01-01

    BACKGROUND: Studies of children's blood lipid profiles in relation to asthma are few, and the results are ambiguous. OBJECTIVE: We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children. METHODS: High...... of increased Feno levels (aβ coefficient, 0.14 log-ppb; 95% CI, -0.02 to 0.30 log-ppb; P = .08). CONCLUSION: The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy...... with assessments of lung function, bronchial responsiveness, fraction of exhaled nitric oxide (Feno), and allergic sensitization. Associations between lipid levels and clinical outcomes were adjusted for sex, passive smoking, and body mass index. RESULTS: High levels of low-density lipoprotein cholesterol were...

  4. [Vocal cord dysfunction. An important differential diagnosis to bronchial asthma].

    Science.gov (United States)

    Kothe, C; Schade, G; Fleischer, S; Hess, M

    2004-03-01

    Vocal cord dysfunction (VCD) is described as a functional disorder of the vocal folds which leads to an intermittent, inspiratory 'paradoxical' glottal closure. We report on three women with frequent repetitive shortness of breath attacks caused by VCD. This was diagnosed by transnasal videofiberendoscopy, with glottal closure being seen during inspiration. Because of the different etiologies, one of the patients was treated with breathing and speech therapy, another received Omeprazol for laryngopharyngeal reflux, and the third was treated by intralaryngeal botulinum toxin injections. All three patients showed a reduction in attacks. Clinically, VCD seems to mimic asthma. However, with a thorough patient history and diagnostics, especially with transnasal laryngoscopy during a (triggered) attack, a precise diagnosis seems possible.

  5. Epidemiological investigation and analysis of bronchial asthma in combat troops garrisoned in the cold areas of northeast China

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    Liang SHI

    2016-04-01

    Full Text Available Objective  To investigate the incidence and related risk factors of occurrence of bronchial asthma in troops garrisoned in the cold areas of northeast China, and explore the corresponding prevention strategy. Methods  A portion of the recruits enlisted in 2012 to Shenyang Command were enrolled as the subjects of the study with three questionnaires. The first questionnaire was carried out during training just after recruit. The second survey was carried out after winter training in selected recruits entering the army for two years, and the last questionnaire was carried out to select recruits just before their discharge from army. The final diagnosis of bronchial asthma in the suspected cases was established by pulmonary function test. Results  In the first period of the survey, the prevalence of asthma was found to be 3.55‰in the newly enlisted recruits; in the second survey 1067 cases were found to be suspicious to have asthma; in the last survey, 26 subjects were finally diagnosed to have asthma, the incidence was 1.73‰. The most common symptoms of the illness at first attack were cough (88.5% and wheeziness (56.3%, and the main inducing factors were respiratory tract infection (76.9% and exposure to cold air (65.4%, and it frequently appeared at early morning (30.8% and forenoon (23.1%. Asthmatic attack presented obvious seasonal predisposition, and it occurred in 19 of 26 patients (73.1% during winter, and 10 (38.5% during spring. The attacks of asthma could be increased by fatigue, allergy, exposure to cold air, chronic bronchitis, smoking, inhalation of gunpowder exhaust, or dysthymia. Conclusion  Fatigue may be the most frequent factor in inducing asthma, and allergy, exposure to cold air, chronic bronchitis, smoking, inhalation of gunpowder exhaust and dysthymia are the risk factors of asthmatic attack. DOI: 10.11855/j.issn.0577-7402.2016.04.13

  6. Discriminant analysis of bronchial asthma by linear discriminant function with parameters of flow-volumes: discriminant analysis of bronchial asthma in young male non-smokers

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    Meguro,Tadamichi

    1978-10-01

    Full Text Available With the parameters of a flow-volume and a volume-time curve, the discriminant analysis of bronchial asthma is described. The subjects were classified into three groups (healthy adults, mild asthmatic patients and moderates ones. The difference of the mean vectors of the parameters of the three groups was made clear by the selection methods of the discriminant analysis between any two of the groups both with 6 parameters (%FVC, FEV1.0%, peak flow rate (PF, flow rate at 50% of FVC (V50, flow rate at 25% of FVC (V25, and V50/V25 and with 8 (6 parameters mentioned above and V75, V10. Forced expiratory volume in 1 second percent (FEV1.0% or V50 was selected at the first step with 6 parameters, and V75 was selected at the first step with 8 parameters. Probabilities of misclassification with 8 parameters were lower than those with 6 ones and the probability of misclassification at the discriminant analysis between healthy adults and mild asthmatic patients with 8 parameters was 15.75% at the final step.

  7. Current Approaches to the Choice of Basic Therapy for Mild Persistent Bronchial Asthma in Children

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    S.M. Nedelska

    2015-04-01

    Conclusions. Leukotrien modifier as monotherapy is indicated to 6–7-year-old children with mild persistent bronchial asthma and serum levels of leukotrienes from 500 to 1000 pg/ml. At the level of leukotrienes below 500 pg/ml it is advisable to administer fluticasone propionate, above 1000 pg/ml — combination of leukotrien modifier and inhaled corticosteroid.

  8. 47 Year Old Patient with Pseudo-Asthma

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    Bulent Altinsoy

    2011-01-01

    Full Text Available 47- year- old female patient presented in out-patient department in Afyon Chest Disease Hospital with dyspnea, cough and purulent sputum. She has been receiving regular inhaler β-agonist and corticosteroids with the diagnosis of asthma bronchial since childhood. However, the patient had a history of very often upper and lower respiratory tract infections. The patient did not smoke, drink alcohol, or use illicit drugs intravenously. She was currently on asthma medications.

  9. Value of past clinical history in differentiating bronchial asthma from COPD in male smokers presenting with SOB and fixed airway obstruction

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    Prahlad Rai Gupta

    2015-01-01

    Full Text Available Objective: Differentiating asthma from chronic obstructive pulmonary disease (COPD is difficult. Steroid trial may be of help but has several pitfalls. The present study aims to assess the value of past clinical profile of asthma and its differential diagnosis from COPD in male smokers and thereby to formulate clinical parameters to diagnose bronchial asthma in such patients. Patients and Methods: Male smokers who reported at the Respiratory Medicine Department of the National Institute of Medical Sciences (NIMS Hospital, Jaipur, (India, with shortness of breath (SOB and showing less than 12% postbronchodilator bronchial reversibility (BR on spirometry were recruited. These patients were given oral prednisolone 1 mg/kg for two weeks. Post steroid (PS spirometry was performed to ascertain BR. The past clinical history was recorded and analyzed to determine if it is of any use in differentiating asthma from COPD. Result: Out of 104 patients, four were lost to follow up, 52 were diagnosed as bronchial asthma, and the remaining 48 as COPD. It was revealed that past history of (H/O seasonal variation, wheezing, eye allergy, nasal allergy, dust allergy, skin allergy, and family H/O asthma/allergy were positive in 50, 40, 34, 30, 18, 14, and 12 asthma patients as compared to 10, 8, 2, 4, 6, 0, and 0 in 48 COPD patients (P < 0.001. The odds ratio (OR for diagnosing asthma was highest for the presence of any other two symptoms/variables, besides SOB, in the past (OR = 275, P < 0.0001. Conclusion: Past clinical history is of immense value in differentiating asthma from COPD in male smokers presenting with SOB and fixed airway obstruction.

  10. Epidemiology of bronchial asthma in school children (10–16 years in Srinagar

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    Uruj Altaf Qureshi

    2016-01-01

    Full Text Available Objectives: To assess the epidemiological profile of asthma in school going children in Srinagar, Kashmir. Study design: Cross-sectional study. Setting: Thirty-one schools with proportionate representation from both government and private schools as well as from primary, middle, and high schools. Participants: School children aged 10–16 years with equal representation of sex and all ages. Main Outcome Measure: Prevalence of current and past asthma. Methods and Results: After administering a modified pretested questionnaire, peak expiratory flow measurement was carried. Children who had asthma-like symptoms or positive family history of asthma or physician-labeled asthma were subjected to spirometry and bronchodilator reversibility. Out of 806 children, bronchial asthma was seen in 60 (prevalence of 7.4% which included 34 boys and 26 girls. Majority of asthmatic children (78.3% [n = 47] had probable asthma; 6.7% (n = 4 had definite asthma; and 15% (n = 9 had physician-diagnosed asthma. Majority of children had intermittent asthma (78.3% [n = 47]. Mild persistent asthma was seen in 12.7% (n = 7 and 10% (n = 6 had moderate persistent asthma. None of the children had severe persistent asthma. The prevalence of current asthma was 3.2% (n = 26. On univariate analysis, the factors found to be statistically significant were family history of asthma (odds ratio [OR] =8.174; confidence interval [CI] =4.403–15.178, seasonal cough (OR = 4.266; CI = 2.336–7.791, allergic rhinitis (OR = 2.877; CI = 1.414–5.852, atopic dermatitis (OR = 6.597; CI = 2.72–16.004, and obesity (OR = 6.074; CI = 2.308–18.034. On multivariate analysis, family history, seasonal cough, allergic rhinitis, atopic dermatitis, and obesity were found to be significant independent risk factors. Conclusions: Srinagar qualifies as a low prevalence area for bronchial asthma in the age group of 10–16 years. Majority of children had mild intermittent asthma resulting in under

  11. [Roles of histamine in the pathogenesis of bronchial asthma and reevaluation of the clinical usefulness of antihistamines].

    Science.gov (United States)

    Yamauchi, Kohei; Shikanai, Toshiki; Nakamura, Yutaka; Kobayashi, Hitoshi; Ogasawara, Masahito; Maeyama, Kazutaka

    2011-02-01

    Histamine has been reported to play an important role in pathogenesis of bronchial asthma. However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. We therefore evaluated its role in allergic airway inflammation with the use of histamine-deficient mice. The results suggested that histamine plays a role in the prevention of goblet cell hyperplasia. Organic cation transporter-3 (OCT-3) is thought to be a transporter of histamine. Polymorphism of OCT-3 {R120R (T/C)} was associated with the severity of asthma. Recently, it has been proposed that both asthma and allergic rhinitis should be treated as a single airway disease. Comorbidity of asthma and allergic rhinitis is very high (70-80%) and they share similar allergic inflammation. H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. Therefore H1-blockers are strongly recommended for patients with both asthma and allergic rhinitis.

  12. Rare case of pneumorrhachis, pneumomediastinum, pneumothorax, and surgical emphysema secondary to bronchial asthma

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    Mahajan PS

    2014-03-01

    Full Text Available Parag Suresh Mahajan,1 Nasser Jassim Al Maslamani,1 Nishan K Purayil2 1Department of Radiology, 2Accident and Emergency Department, Al Khor Hospital, Hamad Medical Corporation, Doha, Qatar Abstract: Air localized within the spinal canal is called pneumorrhachis. In the case of pneumorrhachis, air can be present in the extradural, the intradural, or the subarachnoid space of the spinal canal. The air within the soft tissue of the posterior mediastinum may dissect along fascial planes, through the intervertebral neural foramina, and into the extradural or the subarachnoid space. Nontraumatic pneumorrhachis is a rare presentation. Most of the time, pneumorrhachis is asymptomatic, remains localized, and resolves spontaneously. There are very few reports of combined presence of pneumomediastinum and extradural pneumorrhachis not associated with thoracic injury in the published literature. We report a rare case of pneumorrhachis, pneumomediastinum, pneumothorax, and surgical emphysema in an adult female patient developed after a bout of violent cough related to bronchial asthma. Keywords: pneumorrhachis, pneumomediastinum, pneumothorax, surgical emphysema, asthma

  13. EFFECTS OF TGF-β1 ON LUNG FIBROBLASTS IN PATIENTS WITH BRONCHIAL ASTHMA%TGF-β1对支气管哮喘病人肺成纤维细胞的作用

    Institute of Scientific and Technical Information of China (English)

    孙文静; 杜春华; 隋爱华

    2013-01-01

    目的 通过观察转化生长因子β1(TGF-β1)对支气管哮喘病人肺成纤维细胞增殖和分泌的影响,探讨二者在支气管哮喘气道重塑中的作用.方法 采用组织块贴壁培养方法,分离和原代培养哮喘病人肺成纤维细胞,免疫荧光法鉴定.以0、1、5、10 μg/L TGF-β1分别作用肺成纤维细胞48 h,MTT法测定成纤维细胞增殖情况,RT-PCR法测定肺成纤维细胞Ⅰ型胶原(Collagen Ⅰ)mRNA表达水平.结果 组织块贴壁法成功地培养出了肺成纤维细胞.免疫荧光法鉴定证明,原代培养出的细胞为肺成纤维细胞.不同浓度的TGF-β1均可促进哮喘病人肺成纤维细胞增殖,诱导哮喘病人肺成纤维细胞Collagen Ⅰ mRNA的表达水平上调,呈浓度依赖性(F=44.723、24.704,P<0.05).结论 在哮喘发病机制中,TGF-β1可促进肺成纤维细胞的增殖,合成和分泌Collagen Ⅰ,从而引起气道黏膜下纤维化和胶原沉积,导致哮喘病人气道重塑.%Objective To investigate the effects of TGF-β1 on proliferation and secretion in lung fibroblasts of patients with bronchial asthma (BA) and explore their roles in airway remodeling.Methods The tissue explant adherent method was used for isolation and primary culture of lung fibroblasts of BA patients.The cells were identified by immunofluorescence.MTT and RT-PCR were used to detect the levels of proliferation and collagen Ⅰ mRNA expression in fibroblasts,respectively,after stimulation by different concentrations (0,1,5 and 10μg/L) of TGF-β1.Results Lung fibroblasts were cultured successfully and confirmed by immunofluorescence.All the different concentrations of TGF-β1 could motivate the proliferation of the fibroblasts in asthma patients,and induce up-regulation of collagen Ⅰ mRNA expression,which was concentration-dependent (F=44.723,24.704;P<0.05).Conclusion In the pathogenesis of asthma,TGF-β1 can promote the proliferation,synthesis and secretion of collagen Ⅰ in lung

  14. The Effectiveness of Practicing Pranayama Yoga on Some Respiratory Indicators in Patients Suffering from Bronchial Disease

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    Khue Ai Thi HOANG

    2015-06-01

    Full Text Available Bronchial asthma is considered as a large burden of disease cross the world wasting billions of dollars each year. Using drug for treatment is not only expensive but also causes many adverse health affect. The study aim s to assess the effects of pranayama yoga practice on lung functions in patients with bronchial diseases. This is a controlled trial study. After three months of yoga practice, breath indicators such as FVC, FEV 1, FEV1/FVC, PEFR of intervention group sign ificantly improved with p value < .01 to .001 in comparison wi th the previous three months of the control group. Practicing pranayama yoga is beneficial to patients with bronchial asthma.

  15. FeNO and Bronchial Responsiveness are Associated and Continuous traits in Young Children Independent of Asthma

    DEFF Research Database (Denmark)

    Schoos, Ann-Marie Malby; Chawes, Bo Lund Krogsgaard; Bønnelykke, Klaus;

    2012-01-01

    ABSTRACT BACKGROUND Elevated fraction of exhaled nitric oxide (FeNO) and bronchial hyperresponsiveness are used as surrogate markers of asthma. These traits may be continuous in the population. OBJECTIVE To investigate whether FeNO and bronchial responsiveness are associated both in children...... with and in children without a history of asthma symptoms. METHODS 196 six-year-old children comprising asymptomatic children, children with intermittent asthmatic symptoms and children with persistent asthma were randomly included from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC2000) high...... adjustment for gender, allergic rhinitis, current asthma, inhaled corticosteroid treatment and upper respiratory tract infections prior to testing. Stratified analyses showed similar associations in children with and without asthma. CONCLUSION FeNO and bronchial responsiveness are associated traits...

  16. Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes

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    Yoshifumi Hoshino

    2015-04-01

    Conclusions: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation.

  17. 11.3.Upper respiratory tract disease and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920096 A clinical trial of treating asthma ofmoderate severity with beclomethason dip-ropionate aerosol.SHEN Xun (沈勋),et al.DeptPulmon Med,Zhongshan Hosp,Shanghai MedUniv,200032.Chin J Intern Med 1991; 30 (9):536-538.In order to investigate the efficacy of steroidinhalation in treating asthma of moderate sever-

  18. Adipose tissue content and distribution in children and adolescents with bronchial asthma.

    Science.gov (United States)

    Umławska, Wioleta

    2015-02-01

    The excess of adipose tissue and the pattern of adipose tissue distribution in the body seem to play an important role in the complicated dependencies between obesity and risk of developing asthma. The aim of the present study was to determine nutritional status in children and adolescents with bronchial asthma with special emphasis on adipose tissue distribution evaluated on the basis of skin-fold thicknesses, and to determine the relationships between patterns of adipose tissue distribution and the course of the disease. Anthropometric data on height, weight, circumferences and skin-fold thicknesses were extracted from the medical histories of 261 children diagnosed with asthma bronchitis. Values for children with asthma were compared to Polish national growth reference charts. Distribution of subcutaneous adipose tissue was evaluated using principal components analysis (PCA). Multivariate linear regression analyses tested the effect of three factors on subcutaneous adipose tissue distribution: type of asthma, the severity of the disease and the duration of the disease. Mean body height in the children examined in this study was lower than in their healthy peers. Mean BMI and skin-fold thicknesses were significantly higher and lean body mass was lower in the study group. Excess body fat was noted, especially in girls. Adipose tissue was preferentially deposited in the trunk in girls with severe asthma, as well as in those who had been suffering from asthma for a longer time. The type of asthma, atopic or non-atopic, had no observable effect on subcutaneous adipose tissue distribution in children examined. The data suggest that long-treated subjects and those with severe bronchial asthma accumulate more adipose tissue on the trunk. It is important to regularly monitor nutritional status in children with asthma, especially in those receiving high doses of systemic or inhaled glucocorticosteroids, and long-term treatment as well. Copyright © 2014 Elsevier Ltd. All

  19. 心理护理对支气管哮喘患者分娩期哮喘急性发作的预防作用%The Preventive Effect of Psychological Nursing for Acute Asthma Attacks of Bronchial Asthma Patients in the Stage of Labour

    Institute of Scientific and Technical Information of China (English)

    李玉铭

    2013-01-01

      目的:探讨心理护理对支气管哮喘患者分娩期哮喘急性发作的预防作用。方法:对2011年10月-2013年1月在笔者所在医院妇产科住院的分娩期支气管哮喘患者70例,采用随机抽样方法平均分成心理护理组和对照组,其中对照组进行产科分娩常规护理,心理护理组在产科分娩常规护理的基础上加强心理护理,利用状态焦虑量表(SAI)和多功能心电监护仪,评测患者分娩期第一产程的焦虑程度及记录其血压、心率、血氧饱和度的变化,并观察患者分娩期哮喘急性发作的情况。结果:心理护理组患者的焦虑程度明显低于对照组,差异有统计学意义(P<0.01);心理护理组患者的血压、心率、血氧饱和度的变化低于对照组,差异有统计学意义(P<0.05);心理护理组患者分娩期哮喘急性发作的例数少于对照组,差异有统计学意义(P=0.029)。结论:对分娩期支气管哮喘患者加强心理护理,能显著缓解其焦虑情绪,稳定患者的血压、心率及血氧饱和度,有效地预防与控制支气管哮喘患者分娩期哮喘的急性发作。%  Objective:To explore the preventive effect of psychological nursing for acute asthma attacks of bronchial asthma patients in the stage of labour. Methods:70 bronchial asthma patients in the stage of labour in our hospital from October 2011 to January 2013 were randomly divided into psychological nursing group and control group.The nursing methods of control group were routine obstetrical nursing.Excepting routine obstetrical nursing,psychological nursing group also enhanced the psychological nursing.By using SAI and multifunctional ECG monitor,to evaluate the anxiety levels of patients,in the meantime,recorde the changes of their blood pressures,heart rates and oxyhemoglobin saturations.Furthermore,to observe the numbers of patients with acute asthma attacks between psychological nursing group and

  20. 支气管哮喘患儿不同治疗方法内皮素和降钙素基因相关肽结果比较%Study of endothelin and calcitonin gene-related peptide levels in children with bronchial asthma by different therapies

    Institute of Scientific and Technical Information of China (English)

    吕汉文; 卢远达; 徐淑兰; 叶彩丽; 林灿华; 周翔

    2002-01-01

    Background: Bronchial asthma is an allergic pulmonary disease. The attack is mostly induced by the inhalation of or contact with allergens, such as pollens, dusts, insects (such as mite), germs, etc. During the attack, patients have severe dyspnea which is due to spasm of bronchial smooth muscles, swelling of the bronchial mucosa, and hypersecretion of the mucus, leading to bronchial obstruction. To observe the endothelin(ET) and calcitonin gene related peptide(CGRP) changes in treating children with bronchial asthma by dopamine( DP), dobutamine( DOB),and regitine.

  1. Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells

    Science.gov (United States)

    Alexandrova, Elena; Nassa, Giovanni; Corleone, Giacomo; Buzdin, Anton; Aliper, Alexander M.; Terekhanova, Nadezhda; Shepelin, Denis; Zhavoronkov, Alexander; Tamm, Michael; Milanesi, Luciano; Weisz, Alessandro

    2016-01-01

    Background Bronchial smooth muscle (BSM) cells from asthmatic patients maintain in vitro a distinct hyper-reactive (“primed”) phenotype, characterized by increased release of pro-inflammatory factors and mediators, as well as hyperplasia and/or hypertrophy. This “primed” phenotype helps to understand pathogenesis of asthma, as changes in BSM function are essential for manifestation of allergic and inflammatory responses and airway wall remodelling. Objective To identify signalling pathways in cultured primary BSMs of asthma patients and non-asthmatic subjects by genome wide profiling of differentially expressed mRNAs and activated intracellular signalling pathways (ISPs). Methods Transcriptome profiling by cap-analysis-of-gene-expression (CAGE), which permits selection of preferentially capped mRNAs most likely to be translated into proteins, was performed in human BSM cells from asthmatic (n=8) and non-asthmatic (n=6) subjects and OncoFinder tool were then exploited for identification of ISP deregulations. Results CAGE revealed >600 RNAs differentially expressed in asthma vs control cells (p≤0.005), with asthma samples showing a high degree of similarity among them. Comprehensive ISP activation analysis revealed that among 269 pathways analysed, 145 (ppromoting pathways and up-regulated ones affecting cell growth and proliferation, inflammatory response, control of smooth muscle contraction and hypoxia-related signalization. Conclusions These first-time results can now be exploited toward development of novel therapeutic strategies targeting ISP signatures linked to asthma pathophysiology. PMID:26863634

  2. The detection of serum protein C for the bronchial asthma patients condition and prognosis assess%血浆蛋白C活性测定对支气管哮喘患者病情和预后的评估

    Institute of Scientific and Technical Information of China (English)

    门剑龙; 陈宏; 刘瑞玲; 任静

    2014-01-01

    重发作风险相关,可作为评价患者病情发展和哮喘控制的有效指标。%Objective To study the assessment value of serum protein C activity ( PC∶A) test in the patient′s condition and prognosis in bronchial asthma.Methods 202 bronchial asthma patients were selected from the Tianjin medical university general hospital from 2010 to 2012 for this retrospective cohort study, 77 males and 125 females with a mean age of 41.2 ±11.4 years.the level of PC∶A were analysed by IL ACL TOP 700 coagulation analyzer.Receiver operating characteristic curve ( ROC) was used to analyze the diagnosis performance of PC∶A, χ2 test was used to analyze the relevance between PC∶A and clinical pathological factors , Cox regression analysis model was used to evaluate the effect on prognosis , Kaplan-Meier curve to implement survival analysis.Results The elevels of PC∶A were:control group ( 102.2 ± 13.6)%, intermittent attack group (104.8 ±11.9)%, mild persistent group (136.3 ±15.8)%, moderate persistent group ( 129.0 ±13.5 )% and severe persistent ( 126.8 ±14.7 )% respectively , and there was significantly difference among the all groups ( F =7.15, P <0.01 ).Compared the control group and intermittent attack group with other groups , the PC∶A level was higher in mild persistent group ( q=16.83, q=15.54, P<0.05), moderate persistent group (q=19.94,q=12.15, P<0.05), and severe persistent group(q=11.37,q=10.66, P<0.05).The PC∶A level was lower in moderate and severe persistent group than mild persistent group ( q =3.82, q =4.30, P <0.05 ).After undergoing regular treatment for six months, the PC∶A level was higher in partly controlled group and uncontrolled group than complete controlled group (q=12.45, q=9.91,P<0.05).The optimum cut-off point of PC∶A (after undergoing regular treatment for six months ) for asthma condition with uncontrolled was 118.0%, the area under ROC curve was 0.892 ( 95% confidence interval:0.851-0.936 ).The χ2 test results

  3. 无创双水平正压通气辅治重症支气管哮喘患者的疗效观察%The clinical efficacy of NIPPV assisted treatment for patients with severe bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    余让辉; 吴晓宁; 方永光

    2015-01-01

    Objective To observe the therapeutic value of noninvasive bi level positive pressure ventilation ( NIPPV) in patients with severe bronchial asthma .Methods From January 2012 to January 2014 , selected 60 patients with severe bronchial asthma , according to the random number table method , they were divided into the observation group and the control group with 30 cases in each group .The control group was treated with oxygen therapy plus medication , and the observation group was treated with NIPPV on the basis of treatment in the control group .The blood gas and pulmonary function before treatment and 1h, 12h, 24h, 72 h after treatment were compared , and followed up 3 months of the clinical effect .Results Compared with before treatment , 2 groups of patients 1h, 12, 24 h and 72 h after treatment, the pH, PaO2 and SaO2 gradually increased, PaCO2 gradually decreased ( P 0.05).Conclusion Based on oxygen therapy and drug treatment , NIPPV can improve ventilation of patients with severe bronchial asthma and lung function with reliable clinical curative effect .%目的:观察无创双水平正压通气(NIPPV)在重症支气管哮喘患者中的治疗价值。方法选取2012年1月—2014年1月住院治疗的重症支气管哮喘患者60例,按随机数字表法分为观察组和对照组各30例。对照组予以氧疗+药物治疗,观察组在对照组基础上加用NIPPV治疗。对比2组患者治疗前及治疗后1、12、24、72 h的动脉血气指标、肺功能变化,并随访3个月后的临床疗效。结果与治疗前比较,2组患者治疗1、12、24、72 h后的pH、PaO2和SaO2逐步上升,PaCO2逐步下降( P均<0.05);观察组治疗1、12、24、72 h后的pH、PaO2和SaO2均高于对照组,PaCO2低于对照组( P均<0.05)。与治疗前比较,治疗1周后,2组患者的FEV1、FEV1/FVC、PEF均显著升高(P <0.05),且观察组的FEV1、FEV1/FVC和PEF较对照组显著升高( P <0.05

  4. Asthma control: Patient and environment

    NARCIS (Netherlands)

    Rijssenbeek-Nouwens, L.H.M.

    2015-01-01

    Control of asthma, the goal of asthma treatment, seems hard to obtain. However, it is largely unknown why control of asthma remains difficult in many patients in spite of available powerful medication. In this thesis we studied non-pharmacological factors influencing asthma control: patient related

  5. [Genetics of the neuronal NO synthase (NOS1) in the etiology of bronchial asthma].

    Science.gov (United States)

    Grasemann, H

    2001-08-01

    The free radical nitric oxide (NO) is endogenously produced by enzymes known as NO synthases. NO in the airways is involved in a number of pathophysiological processes, such as airway inflammation, allergic reactions, and asthma. Asthma is a multifactorial disease that is caused by environmental and genetic factors. Genome wide screening approaches in families revealed evidence for linkage between chromosomal region 12q and allergic diseases, increased serum IgE levels as well as the development of asthma. The gene encoding for neuronal NOS (NOS1) is an attractive candidate gene for asthma, not only because it is localized in chromosomal region 12q24. Experimental studies in animals and humans suggest that NOS1 plays an important role in asthma. For instance, in a murine model of allergic asthma, NOS1 has been shown to be important for the development of bronchial hyperresponsiveness, since mice deficient for the nos1 gene were less responsive to airway challenge than both wild-type mice and mice deficient for the nos2 gene. Case-control studies in humans revealed allelic associations between polymorphic markers in the NOS1 gene and the diagnosis of asthma. Furthermore, increased concentrations of NO in the airways of asthmatics are closely related to the size of an intronic (AAT)(n)-repeat polymorphism in the NOS1 gene. The purpose of this review is to summarize studies that provide evidence for an involvement of NOS1 in the genetics of asthma.

  6. BRONCHIAL ASTHMA AMONG CHILDREN UNDER 8: HOW TO DECREASE THE RECURRENCE OF EXACERBATIONS AND HOSPITALIZATIONS?

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    E.A. Vishneva

    2009-01-01

    Full Text Available The modern approach to the therapy of bronchial asthma among children includes wide application of the inhalant glucocorticosteroids. The application of the spray-based medicines provides for fast admission into the respiratory passages, high local activity, low risk of the systemic side effects. The choice of a specific medicine depends both on the patient’s ability to effectively and correctly use the prescribed medication and a medicine itself. The highest number of hospitalizations and cases of seeking medical emergency advice is recorded among children aged under 4. The only inhalant glucocorticosteroids approved for application among children under 4 is budesonide in a suspension for inhalations.Key words: bronchial asthma, medical emergency advice, inhalant glucocorticosteroids, children.

  7. 优质护理对老年支气管哮喘患者生活质量影响分析研究%Analysis Effect of High Quality Nursing on the Life Quality of Elderly Patients With Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    张佳; 李婷婷

    2015-01-01

    Objective To investigate the effect of high quality nursing on the life quality of elderly patients with bronchial asthma.Methods70 cases of elderly bronchial asthma were selected from October 2014 to October 2015,divided into routine nursing group (control group) and high quality nursing group (experimental group),compared two groups of patients quality of life and nursing satisfaction.Results In the experimental group, the therapeutic effect and quality of life score were significantly better than the control group. Conclusion High quality nursing to improve the quality of life of patients with bronchial asthma in the elderly has good effect.%目的:探讨优质护理对老年支气管哮喘患者生活质量的影响。方法选取我院于2014年10月~2015年10月收治的70例老年支气管哮喘患者,随机分为常规护理组(对照组)与优质护理组(实验组),对比两组患者的生活质量及护理满意度。结果实验组的治疗效果与生活质量评分均显著优于对照组。结论优质护理对提高老年支气管哮喘患者的生活质量具有良好效果。

  8. [Associations of chronic obstructive pulmonary disease, bronchial asthma, and type 1 diabetes mellitus].

    Science.gov (United States)

    Kobylianskiĭ, V I; Babadzhanova, G Iu; Suntsov, Iu I

    2009-01-01

    The aim of the study was to clarify the relationships between bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), and type 1 diabetes mellitus. Reduced prevalence of concomitant BA and DM1 suggests inverse relation between the two conditions and their mutually exclusive nature. The problem needs further studies. Taking into account age-specific and other features of COPD and DM1 pathological processes elucidation of their interrelation appears impractical.

  9. Adherence to the Clinical Good Practical Guide of Bronchial Asthma in the Allergy Consultation

    OpenAIRE

    Marisela Pérez Pacaréu; Rafael Zamora Puerta; Magalys Olivares Elegia; Rosa Naranjo Revollido

    2007-01-01

    Background: Bronchial asthma constitutes a high prevalence disease which gets the 10 % of our milieu. That’s why it is very important to assess its clinical management. The clinical good practice guide constitutes a group of orientations which outline the medical assistance based on what is considered as the best options for treatment and diagnosis. Objective: to determine the adherence of the medical personnel specialized on the clinical good practical guide in the diagnosis and treatment of...

  10. The clinical study on Nebulizing Budesonide combined with Salbutamol in patients with acute attack of bronchial asthma of acute attack%雾化吸入布地奈德和沙丁胺醇治疗支气管哮喘急性发作的临床研究

    Institute of Scientific and Technical Information of China (English)

    丁海运

    2009-01-01

    目的 研究雾化吸入布地奈德和沙丁胺醇治疗支气管哮喘急性发作的效果.方法 60例患者随机分为两组,治疗组30例予布地奈德联合沙丁胺醇雾化吸入,对照组30例仅予沙丁胺醇雾化吸入,观察用药前后15 min、第3 d和第7 d症状改善情况.结果 治疗组治疗15 min后心率、呼吸频率及治疗第3 d、第7d症状评分均较治疗前明显改善(P<0.05).结论 雾化吸入布地奈德和沙丁胺醇治疗支气管哮喘急性发作疗效肯定,值得推广.%Objective To observe the effects of nebulizing Budesonide combined with Salbutamol in patients with acute attack of bronchial asthma of acute attack.Methods 60 patients suffered from acute attack of bronchial asthma were randomly divided into two groups,that is,the therapeutic group(n=30)was treated by nebulized Budesonide combined with Salbutamol and the control group(n=30)was treated only by nebulized Salbutamol.The symptoms and signs were measured before the treatment,and 15 minutes,3 days and 7days after the treatment.Results The heart rates and breathing frequency of the treatment group were improved significandy(P<0.05).Conclusion Nebulizing Budesonide combined with Salbutamol can be used to treat the acute attack of bronchial asthma effectively.

  11. EFFICACY OF JOSHANDA ZEEQUNNAFAS AND HABBE HINDI ZEEQI IN ZEEQUNNAFAS (BRONCHIAL ASTHMA - AN OBSERVATIONAL OPEN CLINICAL TRIAL

    Directory of Open Access Journals (Sweden)

    Juned Ahmad

    2014-12-01

    Full Text Available Background: Bronchial asthma is a major public health concern, affecting 100-150 million people worldwide and accounts for an estimated 1,80,000 deaths per year. Its incidence is swiftly escalating in India. Unani medicine is augment with many single and compound drugs, which own potential effects to cure the disease, but these formulations are not proof scientifically. Objective: To evaluate the efficacy of Joshanda Zeequnnafas and Habbe Hindi Zeeqi in the treatment of Zeequnnafas to provide safe and effective treatment for asthma. Methods: The clinical trial to assess the efficacy of Joshanda Zeequnnafas and Habbe Hindi Zeeqi in the management of asthma. 50 patients were screened and out of them 30 patients were selected for study. Joshanda Zeequnnafas and Habbe Hindi Zeeqi were administered orally 50 ml (as decoction twice a day and 125 mg (as tablet form twice a day for 45 days. Subjective and objective parameters follow up before and after treatment on 0, 15th, 30th, and 45th day of the treatment. In subjective parameter, paroxysmal dyspnoea and wheeze was analysed using paired proportion test. Objective parameter was assessed by the help of Spirometry in terms of ESR, Eosinophilia, FEV1, FEV1/FVC% and PEF and student paired t test was applied to get the results. Safety parameters included complete blood count, SGOT, SGPT, Blood urea, S. Creatinine, RBS, and Urine routine and microscopic; and were assessed on student paired t test. Results: The overall result was highly significant in terms of subjective and objective parameters specially FEV1and PEF (P0.178, 0.785, and 0.220 respectively. Conclusion: The study results suggest that the trials formulations are quite effective in the management of Zeequnnafas. No adverse effects were noted during the complete course of the study trial. Hence it infers that trial drugs are safe, and effective in the treatment of Zeequnnafas (bronchial asthma.

  12. Is affluence a risk factor for bronchial asthma and type 1 diabetes?

    Science.gov (United States)

    Tedeschi, Alberto; Airaghi, Lorena

    2006-11-01

    In the last decades, an increase in bronchial asthma and type 1 diabetes occurrence has been observed in affluent countries, and a positive association between the two disorders has been demonstrated at the population level. This association could be explained by common risk factors predisposing to both disorders. Altered environmental and lifestyle conditions, possibly related to socio-economic status, might account for the rising trend of the two disorders. To test this hypothesis, we calculated the correlation between the occurrence of type 1 diabetes and asthma, the gross national product (GNP) and the infant mortality rate, in several European and extra-European countries. GNP was positively correlated with the incidence of type 1 diabetes and with symptoms of asthma in European (r(sp): 0.53 and 0.69; p = 0.001 and p diabetes; r(sp):- 0.51, p = 0.01 for asthma). In extra-European countries, a significant relationship was found between infant mortality and asthma (r(sp): -0.46; p = 0.03); a trend towards a negative correlation between infant mortality and type 1 diabetes was also found, although no statistical significance was reached (r(sp): -0.21; p = 0.31). This analysis indicates that type 1 diabetes and asthma are positively associated with the GNP at the population level. Similarly, countries with low infant mortality rates tend to have a higher incidence of these immune-mediated diseases. Although GNP reflects many societal and lifestyle differences, it is notable that a high socio-economic status implies a reduced or delayed exposure to infectious agents. The reduced pressure of infectious agents on the immune system throughout life might contribute to increase the susceptibility to bronchial asthma and type 1 diabetes.

  13. A Pilot Study: Effects of Dietary Supplementation with α-Linolenic Acid-Enriched Perilla Seed Oil on Bronchial Asthma

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    Kozo Ashida

    1997-01-01

    Full Text Available N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA, parent n-3 fatty acid, were studied in five patients with asthma. The symptoms of asthma and mean peak flow rates (PFR both early in the morning and in the evening were improved 2 weeks after dietary supplementation and the increases in PFR were significant (P<0.05. The generation of leukotriene B4 (LTB4 by peripheral leukocytes stimulated with the Ca2+ ionophore A23187 was significantly suppressed from 77.6 to 41.6 ng/5Xl06 cells by dietary supplementation (P<0.05. The generation of leukotriene C4 (LTC4 by leukocytes was also significantly suppressed from 64.0 to 38.8 ng/5x106 cells after supplementation with perilla seed oil (P<0.05. These results suggest that dietary supplementation with perilla seed oil is beneficial for the treatment of asthma.

  14. The expression of serum interleukin-33, interleukin-35 in patients with bronchial asthma and their correlation%支气管哮喘患者血清IL-33、IL-35水平及相关性分析

    Institute of Scientific and Technical Information of China (English)

    陈杰; 彭健; 张卓然; 程国平

    2015-01-01

    Objective To investigate the expression of serum interleukin-33 (IL-33),interleukin-35 (IL-35) in patients with bronchial asthma and their correlation.Methods The expression of serum IL-33,IL-35 of 81 patients with moderate or severe bronchial asthma in acute episode not caused by bacterial infection were detected with ELISA before treatment,along with 80 normal controls.The numbers of white blood cell (WBC),absolute neutrophil count (N),eosinophil absolute value (EOS) were detected by blood cell analyzer.In cell culture experiments,the plasma sample was divided into 3 groups:control group,cell stimulating hormone group,and IL-35 group.After cell culture experiments,the expression of plasma IL-33 in each group was measured by ELISA.Compared the expression of serum IL-35,IL-33,WBC,N,EOS in patients with bronchial asthma in acute episode and normal controls,analyzed the correlation between IL-35 and IL-33.Results ① The numbers of WBC,N,EOS of bronchial asthma group were higher than those of control group [(7.82±2.93)× 109/L vs.(6.38±2.14)× 109/L;(5.63± 1.47)× 109/L vs.(4.57± 1.22)× 109/L;(0.43±0.27)× 109/L vs.(0.22±0.15) × 109/L;P<0.001].② The expression of serum IL-33 of bronchial asthma group was significantly higher than that of control group [(217.26±52.31)ng/L vs.(105.43±31.64)ng/L],the expression of serum IL-35 was significantly lower than that of control group [(156.71±24.29)ng/L vs.(311.62±35.28)ng/L],with statistically significant differences (P<0.05).③The expression of serum IL-33 of patients with bronchial asthma undergoing IL-35 stimulating was lower that of patients with bronchial asthma undergoing cell stimulating hormone [(15.08±1.92)ng/L vs.(57.33±15.62)ng/L],with statistically significant difference (P<0.05).Conclusion IL-35,IL-33 were involved in the pathogenesis of bronchial asthma.Cytokines regulating unbalance existed in acute episode of bronchial asthma.%目的 研究支气管哮喘患者血清IL-33、IL-35

  15. [Epidemiologic aspects of bronchial asthma in the Mexican Republic].

    Science.gov (United States)

    Martínez-Cairo Cueto, S; Salas-Ramírez, M; Segura-Méndez, N H

    1995-01-01

    This work was done to determine the mortality and morbidity rates secondary to asthma in Mexico, for age, gender, state of the country and time. Data were obtained from the Instituto Nacional de Estadística. Geografía e Informática. We calculated morbidity and mortality rates adjusting for age, by a direct method. In the results, there was a reduction in mortality rate in both genders, from 1960 to 1987. Age groups up to 4 years and older than 50 were the mainly affected. From 1960 to the present time, the state with highest mortality is Tlaxcala. The states with highest hospitalization rates were Morelos, Baja California Sur, Nuevo León, Durango and Tamaulipas. In conclusion, mortality rates secondary to asthma in Mexico show a decreasing trend, with a considerable rise in morbidity, especially in the adolescent group.

  16. IMPACT OF THE TYPE OF A BASIC THERAPY ON THE QUALITY OF LIFE IN CHILDREN WITH CONTROLLED MODERATELY SEVERE BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    S.V. Bychkovskaya

    2010-01-01

    Full Text Available The article provides results of a study for the impact of low doses fluticasone propionate and sodium nedocromil on the quality of life in children with bronchial asthma. It evidences Statistically valid improvements in the quality of life are identified and achieved control over the disease (90% in a group of patients that were administered fluticasone propionate. A group of patients that were administered sodium nedocromil, did not show statistically valid improvements in the quality of life and control was maintained only in 62% of the patients. Key words: bronchial asthma, treatment, quality of life, fluticasone propionate, sodium nedocromil, children. (Pediatric Pharmacology. – 2010; 7(2:60-64

  17. Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

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    Parco S

    2010-05-01

    Full Text Available Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO, a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthma

  18. Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

    Directory of Open Access Journals (Sweden)

    Sergio Parco

    2010-05-01

    Full Text Available Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO, a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthma

  19. Role of the dosed walking in the physical rehabilitation of children with bronchial asthma

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    Gagara V.F.

    2012-08-01

    Full Text Available The results of research of influence on the respiratory system of children are presented with bronchial asthma of complex of methods of physical rehabilitation. In research 20 children took part 10-11 years. To put got the complex of rehabilitation measures, which included medical physical education. The complex of respiratory gymnastics was directed on the improvement of functioning of the respiratory system, improvement of function of the external breathing, increase of excursion of thorax and strengthening of respiratory muscles. Exercises of this complex were executed children in a slow rate with an accent on control of breathing during implementation of exercises. Additionally conducted engaged in the dosed walking and the special dynamic respiratory exercises were executed on the method of Tolkachev. The indexes of the functional state of the respiratory system of children are appraised. It is set that for patients the indexes of excursion of thorax were increased, vital capacity of lights, forced vital capacity of lights, volume of the forced exhalation for the first second, by volume speed of spades, index of Tifno.

  20. Anxiety and Emotional Aspect of Bronchial Asthma in School Age Children

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    E.I. Burbela

    2016-06-01

    Full Text Available An examination of 121 children with bronchial asthma (BA and 226 healthy adolescents aged 12.98 ± 2.80 and 12.36 ± 2.80 years, respectively, was conducted. The aim of the study: to explore the personal and psychological component of BA in schoolchildren. All children were observed to determine the psychological type of personality and emotional stability condition by Eysenck Personality Inventory (EPI, to evaluate anxiety in the structure of personality by Spielberger test adapted by B. Hanin, and to assess anxiety at school by Phillips’s questionnaire.BA in children was accompanied by severe anxiety reactions with layering on features of mostly disturbing personality, cau­sing emotional discomfort that intensified with increasing seve­rity of the disease and decreased with increased control of the disease. One of the biggest sources of anxiety is the school environment. In all age groups of BA patients, symptoms of general school anxiety were detected, with dominance of two types of temperament: melancholics (32.23 %, n = 39 — emotionally unstable introverts, and cholerics (31.40 %, n = 38 — emotio­nally unstable extroverts in contrast to the control group, where the largest part was represented by emotionally stable extroverts — sanguine persons. Thus, high anxiety and emotional instability in children with BA determine the need of psychocorrention work among this category of pupils to successfully treat them.

  1. Treatment of 98 Cases of Bronchial Asthma By Plum-blossom Magnetic Needle

    Institute of Scientific and Technical Information of China (English)

    QI Pin-jia

    2005-01-01

    按梅花磁针综合疗法的要求,以梅花磁针针刺相应穴位,结合贴敷增效垫.98例患者,治疗1~2疗程后显效50例,好转39例,无效9例,总有效率为92.8%.梅花磁针综合疗法是治疗支气管哮喘的一种有效疗法.%In accordance with the requirement of comprehensive therapy of plum-blossom magnetic needle, the corresponding acupoints were punctured by plum-blossom needles, in combination with effect-enhancing pad. In 98 cases of the patients, after 1-2 courses of the treatments, the results showed remarkable effect in 50 cases, improvement in 39 cases and failure in 9 cases, in the total effective rate of 92.8%. Comprehensive therapy of plumblossom magnetic needle is an effective therapy for bronchial asthma.

  2. Analysis of Inhaled Corticosteroid Selection in Patients with Bronchial Asthma Using a Questionnaire Survey—Effects of Age, Gender, and Disease Severity—

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    Kyuma Ota

    2009-01-01

    Conclusions: Our study indicates that ICS selection is reasonably adapted to each patient's background at least in the surveyed area. We need to elucidate the characteristics of ICS selection further in the future as new ICS and devices are developed.

  3. REGULAR OBSERVATION OF CHILDREN WITH BRONCHIAL ASTHMA BY ALLERGOLOGIST AND ITS INFLUENCE ON CLINICAL AND FUNCTIONAL PARAMETERS OF THE DISEASE AND CONSUMPTION OF HEALTHCARE RESOURCES

    Directory of Open Access Journals (Sweden)

    I.P. Artyukhov

    2011-01-01

    Full Text Available In real practice, treatment of patients with bronchial asthma (BA is accompanied by unreasonable increase of healthcare resources consumption because of unplanned visits to the doctor due to health worsening, hospital treatment of exacerbations and emergency calls. Objective: to evaluate an effectiveness of children’s with bronchial asthma observations by allergologist. Methods: the dynamics of clinical and functional signs and frequency of emergency claims was analyzed in 115 children with BA who were observed by allergologist once in 3 months during one year. Results: in 3 months of regular observation by allergologist the number of children with day and night symptoms of BA and patients with daily rescue use of short-acting 2-agonists decreased, there were fewer children with limitations of physical activity. The number of patients with normal FEV1 increased in 6 months. Regular observation with allergologist resulted in reduction of number of patients with exacerbations and hospitalizations, shortening of acute period of BA and hospital stay, decreasing of emergency claims rate compared to those who were observed by GPs. Conclusion: regular observation by allergologist once in 3 months results in stabilization of clinical and functional state in patients with BA and decreases the consumption of emergency care resources.Key words: children, bronchial asthma, allergologist, clinical and functional state, healthcare resources.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (3: 55–59

  4. Bronchial hyperresponsiveness to mannitol, airway inflammation and Asthma Control Test in atopic asthmatic children.

    Science.gov (United States)

    Attanasi, Marina; Consilvio, Nicola P; Rapino, Daniele; Nicola, Marta Di; Scaparrotta, Alessandra; Cingolani, Anna; Petrosino, Marianna I; Filippo, Paola Di; Di Pillo, Sabrina; Chiarelli, Francesco

    2016-02-01

    The aim of this study was to evaluate the relationship between airway hyperresponsiveness (AHR) to mannitol and bronchial inflammation measured as exhaled nitric oxide (FeNO) and to assess whether asthma control correlates with AHR to mannitol and FeNO in atopic asthmatic children. Allergy evaluation, the mannitol challenge test, FeNO levels and the Asthma Control Test (ACT) questionnaire were assessed in 40 children with intermittent and mild persistent allergic asthma. All the subjects showed positive AHR to mannitol. Pearson's correlation test revealed a significant inverse correlation between AHR (mannitol PD15) and FeNO (p = 0.020). There was also a significant positive correlation between ACT and PD15 (p = 0.020) and a significant negative correlation between ACT and FeNO levels (p = 0.003). The study population was divided into two groups according to FeNO levels (group A ≥ 16 ppb vs. group B ppb). In group A mannitol PD15 was significantly lower (p = 0.040) and ACT score values were significantly lower (p = 0.001) compared to group B. In group A, the ACT showed that 13.3% of subjects had well-controlled asthma, 80% had partially controlled asthma and 6.7% had uncontrolled asthma. In group B, the ACT showed that 72% of subjects had well-controlled asthma and 28% had partially controlled asthma. Our findings indicate that the degree of AHR to mannitol correlates with the degree of airway inflammation in asthmatic atopic children; moreover, better control of asthma correlates with a lower degree of AHR to both mannitol and FeNO.

  5. 妊娠期支气管哮喘治疗进展%Achievement of bronchial asthma therapy during pregnancy

    Institute of Scientific and Technical Information of China (English)

    蒋雷服; 殷凯生; 黄茂

    2010-01-01

    临床研究已证明妊娠期重度及控制不佳的支气管哮喘(简称哮喘)与母亲及胎儿严重并发症相关.对于妊娠期哮喘患者,接受药物治疗比存在哮喘症状和哮喘发作更安全.所有程度的持续妊娠哮喘患者都应当应用吸入糖皮质激素作为控制药物,首选布地奈德.白三烯受体拮抗剂可以缓解支气管痉挛、减轻症状、改善肺功能.长效β2受体激动剂对于正在应用吸入糖皮质激素的患者可作为首选的添加药物.吸入短效β2受体激动剂可以作为缓解药物.对于正在接受维持量或接近维持量治疗,无不良反应、临床疗效好的妊娠哮喘患者可以继续进行变应原免疫治疗.%Clinical studies have confirmed that severe or uncontrolled bronchial asthma (asthma)during pregnancy may result in adverse maternal and fetal outcomes. It is safer for pregnant women with asthma to be treated with asthma medications than for them to have asthma symptoms and exacerbations.Inhaled corticosteroids should be considered the controller medication for all severities of persistent asthma in pregnant women, preferably inhaled budesonide. Leukotrienes receptor antagonists protect against bronchoconstriction,reduce asthma symptoms and improve pulmonary function in patients with asthma.Long-acting β2-adrenergic agonists are the preferred adjunct to inhaled corticosteroids therapy in the pregnant patients with asthma. Inhaled short-acting β2-agonists are the rescue therapy. Continuation of allergen immunotherapy is recommended in patients who are at or near a maintenance dose, not experiencing adverse reactions to the therapy,and apparently deriving clinical benefit.

  6. Control Method and the Disease Factors Influencing Compliance of Inhaled Corticosteroids in Patients with Bronchial Asthma%支气管哮喘患者吸入糖皮质激素依从性影响因素及病情控制对策

    Institute of Scientific and Technical Information of China (English)

    孙彩

    2015-01-01

    Objective To analyze patients with bronchial asthma inhaled corticosteroids compliance factors,provide the basis for clinical ef ective control of the il ness.Methods Select our hospital during 2013~2014 treated 120 cases of bronchial asthma and proves the patients treated with inhaled corticosteroids as the research object,to inhaled corticosteroid treatment adherence influence factors were analyzed.Results The study of 120 cases with 24 patients adhere to inhaled corticosteroids,the compliance rate was 20%,the factors influencing patients adhere to inhaled corticosteroid therapy are mainly:hormone fear,expensive,and asthma is longer than the lack of knowledge of prevention and cure,treatment is dif icult to insist to use,etc.Conclusion Ef ect of inhaled corticosteroids in patients with bronchial asthma treatment factors varied,improve patients medication compliance is the key to strengthen health education,psychological nursing,inhaled corticosteroids behavior of specific interventions,and improve the family support,etc.%目的分析支气管哮喘患者吸入糖皮质激素依从性影响因素,为临床有效控制病情提供依据。方法选择我院在2013年~2014年收治的120例支气管哮喘并具备吸入糖皮质激素治疗指证的患者为研究对象,对吸入激素治疗依从性影响因素进行统计分析。结果本次研究的120例患者中有24例坚持吸入糖皮质激素,依从率为20%,影响患者坚持吸入激素治疗的因素主要为:激素恐惧、价格昂贵、哮喘防治知识缺乏、疗程较长难以坚持使用等。结论影响支气管哮喘患者吸入糖皮质激素治疗的因素多种多样,提高患者用药依从性的关键在于加强健康教育、心理护理、吸入激素行为的具体干预以及提高家庭支持等。

  7. Environmental Determinants of Bronchial Asthma among Saudi School Children in Southwestern Saudi Arabia

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    Jobran M. Alqahtani

    2016-12-01

    Full Text Available The aim here was to study the possible environmental and dietary determinants of asthma among school-aged children in Southwestern Saudi Arabia. In a cross-sectional study on a representative sample in Najran in Southwestern Saudi Arabia using an Arabic version of the modified ISAAC Phase III, parent-administered questionnaire data were collected. Skin prick tests (SPTs were performed. The study included 1700 school children, out of them 468 (27.5% were diagnosed with, cases of bronchial asthma and 20.8% (353 reported a 12-month nocturnal cough (as a proxy of severe asthma. In multivariable analysis, the study identified the following risk factors for having asthma or severe asthma: having dogs in the house, being male, being exposed to dense truck traffic on the street, using wood as a cooking fuel, conducting vigorous exercise, consuming eggs, consuming vegetables, having an allergic sensitization to dog hair, and being exposed to Cladosporium, pigweed, and Bermuda grass. On the other hand, the following food stuffs were found to be protective: seafood, fruit, and dairy products. Comprehensive school educational programs for both children and their parents should be adopted to prevent the use of wood in cooking and heating, to ensure that house pets are properly cared for, and to encourage proper dietary habits. Physicians should be informed of the patterns of allergens in order to improve asthma diagnosis and management.

  8. Environmental Determinants of Bronchial Asthma among Saudi School Children in Southwestern Saudi Arabia

    Science.gov (United States)

    Alqahtani, Jobran M.; Asaad, Ahmed M.; Awadalla, Nabil J.; Mahfouz, Ahmed A.

    2016-01-01

    The aim here was to study the possible environmental and dietary determinants of asthma among school-aged children in Southwestern Saudi Arabia. In a cross-sectional study on a representative sample in Najran in Southwestern Saudi Arabia using an Arabic version of the modified ISAAC Phase III, parent-administered questionnaire data were collected. Skin prick tests (SPTs) were performed. The study included 1700 school children, out of them 468 (27.5%) were diagnosed with, cases of bronchial asthma and 20.8% (353) reported a 12-month nocturnal cough (as a proxy of severe asthma). In multivariable analysis, the study identified the following risk factors for having asthma or severe asthma: having dogs in the house, being male, being exposed to dense truck traffic on the street, using wood as a cooking fuel, conducting vigorous exercise, consuming eggs, consuming vegetables, having an allergic sensitization to dog hair, and being exposed to Cladosporium, pigweed, and Bermuda grass. On the other hand, the following food stuffs were found to be protective: seafood, fruit, and dairy products. Comprehensive school educational programs for both children and their parents should be adopted to prevent the use of wood in cooking and heating, to ensure that house pets are properly cared for, and to encourage proper dietary habits. Physicians should be informed of the patterns of allergens in order to improve asthma diagnosis and management. PMID:28036050

  9. CLINICAL SIGNIFICANCE OF UPPER AIRWAYS' LATENT INFECTION'S INFLUENCE FOR THE COURSE OF BRONCHIAL ASTHMA IN CHILDREN

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    N. A. Sukhanova

    2012-01-01

    Full Text Available The study was based on the examination of 100 children (71 boy and 29 girls aged 3–18 years with bronchial asthma in remission. The routine allergological examination was followed up by the immunohistochemical test of deep pharyngeal mucosal cells samples scraped to verify the Chlamydia pneumoniae, Cytomegalovirus hominis, HSV-1, HSV-2, EBV as well as by the bacterioscopic examination of pharyngeal causative and opportunistic pathogens. The immunological examination included evaluation of lymphocyte subpopulation (CD 3+, CD3+CD(16+56++ TNK cells, T helpers (CD3+CD4+, double-positive cells (CD4+CD8+, CD3-CD(16+56+NK cells by means of flow cytometry. Measurements of spontaneous and induced cytokine production (IFN α, IFN γ, IL 4 were taken using the immune assay. The level of specific antibodies (Ig M, Ig G to the relevant infectious agents in the serum was measured as well. These examinations demonstrated that children with bronchial asthma and latent infection of the upper respiratory tract have higher rates of bronchial hyperreactivity (86% as well as more frequent (74,7% uncontrolled or partially controlled course of asthma. According to the examination results, in children with broncial asthma and latent infection of the upper respiratory tract α-interferon induction is oppressed (74,7%, the IL4 in the serum is increased along with a shift of the immune response towards Th2, cytotoxic response is increased, TNK cells are increased (75,5% with simultaneous decrease of NK cells.

  10. A retrospective study on drug utilization in patients with acute exacerbation of bronchial asthma in adults at a tertiary teaching hospital in Bengaluru

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    Basavaraju Thejur Jayadeva

    2016-01-01

    Results: Majority of the prescriptions irrespective of severity received inhalation β2 agonist (formoterol as a bronchodilator. Nebulization route was given for managing the acute exacerbations followed by inhalation route. Hydrocortisone was prescribed to all patients for managing acute exacerbations. Montelukast was used an adjuvant therapy. Most of them were prescribed combination therapy. Doxophylline was prescribed among all the methylxanthines.

  11. A STUDY OF NASAL EOSINOPHILIA IN ASTHMA PATIENTS

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    Ramachandra Prabhu

    2014-05-01

    Full Text Available INTRODUCTION: Asthma is an inflammatory, reversible and progressive disease with episodes of exacerbations. Asthma is now considered as single airway disease and hence comprehensive diagnosis, treatment and follow-up of upper and lower respiratory tract is essential. Both the Nasal and Bronchial mucosa are the elements of united airway disease and Eosinophils measured from this mucosa can be an indirect marker of Airway inflammation in asthma. Eosinophil infiltration is hallmark feature of pathogenesis of asthma which is the trigger for the chronic airway inflammation and these are raised in acute exacerbations. Hence assessing Eosinophil is evidence of serological marker for Airway inflammation (AI. Nasal Smear Eosinophils (NSE is used in asthma with Allergic Rhinitis (AR. This study Using Definition of GINA explores the utility of NSE as marker for management of Asthma. METHODS: In this study 100 patients diagnosed with bronchial asthma attending the outpatient department in KIMS were studied. The severity of asthma was assessed as per FEV1 classification- Adapted from 2007 NHLBI Guidelines for the diagnosis and treatment of Asthma Expert panel Report 3. The Statistical analysis was done with SAS 9.2, SPSS 15.0, Stata 10.1, Med Calc 9.0.1, Systat 12.0 and R environment ver.2.11.1.software. RESULTS: Asthma was more common in Females in this study with M: F ratio of 1.04 and Allergic Rhinitis was found in 55% of Asthmatics. Nasal Eosinophilia was seen in 44% in asthmatic group and 49% in Asthma with Allergic Rhinitis. Absolute Eosinophil count (AEC and Differential count (DC for Eosinophils was almost same in both groups. The Sensitivity of NSE with respect to DC is 70% and in AR group with Asthma and in Asthma group with/without AR it was 38%. Similarly the NSE with respect to AEC was 47% in AR group with Asthma whereas in Asthma group with/without AR it was 38%. CONCLUSIONS: The finding confirms that symptoms, Variable airflow Obstruction and

  12. Functional Significance of Single-Nucleotide Polymorphism (rs11204981 in Filaggrin (flg Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

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    O.P. Volosovets

    2015-03-01

    Full Text Available Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical history of children. Methods. Filaggrin genotyping (rs11204981 was carried out in group of patients with bronchial asthma and control group using real-time polymerase chain reaction (PCR. The level of mRNA expression was assessed by reverse transcription and subsequent real-time PCR. Results. We have found that 5 % of patients in the study group and 2 % in the control group had a minor allele (AA, 27 and 36 %, respectively, — heterozygous allele (GA, 67 and 61 % — major allele (GG. Variants with the AA genotype of the FLG rs11204981 were found 2.4 times more often in patients from the study group than in controls. Heterozygous variant had significantly higher expression in filaggrin in buccal epithelium. Conclusions. We believe that polymorphism in filaggrin gene (rs11204981 can serve as an important prognostic marker for the phenotype of bronchial asthma and atopic dermatitis, and that high levels of expression in the heterozygous state may indicate the protective role of this genotype in the development of allergy.

  13. To Explore the Treatment of Bronchial Asthma in Children%浅析小儿支气管哮喘的治疗

    Institute of Scientific and Technical Information of China (English)

    杨秀珍

    2015-01-01

    Objective To treat children with bronchial asthma and discuss the effect.MethodsSelected 30 cases of child patients treated in our hospital from January 2012 to December 2014 were researched and analyzed. Results22 cases were cured, four patients improved , and the remaining 2 patients invalid, so, improvement of this disease was 93.3 %. Conclusion If getting timely and effective treatment , children with bronchial asthma are generally able to get better results , while the treatment of bronchial asthma has an important role in adults.%目的:对小儿支气管哮喘病的治疗及效果进行探讨。方法随机选取我院2012年1月~2014年12月间收治的本病患儿30例进行研究分析。结果22例患者痊愈,有5例患者有所好转,其余3例患者治疗无效,统计得知,本病的好转率为93.3%。结论小儿支气管哮喘若能进行及时有效的治疗,一般都能够得到较好的疗效,同时对成人支气管哮喘的治疗有重要作用。

  14. [Dynamics of functional parameters in different schemes for bronchial asthma therapy: results of the STRELA-ACT multicentre study].

    Science.gov (United States)

    Ogorodova, L M; Kulikov, E S; Deev, I A; Cherniak, B A; Fassakhov, R S

    2011-01-01

    Different strategies for disease control in real clinical practice are compared in terms of dynamics of functional parameters in patients with persistent bronchial asthma. This prospective multicentre surveillance study was carried out in 19 Russian clinics using the common protocol. The patients were divided in 3 groups in accordance with the changes of basal antiinflammatory therapy during the study period. Group A--stepwise increase in the extent of combined salmoterol/fluticason therapy, group B--long-term stable-dose salmoterol/fluticason therapy, group C--salmoterol/fluticason therapy with gradual decrease of the dose and/or transition to an alternative variant. Statistical analysis using Statistica 6.0 program included data from 543 patients. The results suggest that the two first modalities increased the level of control (ACT test) and improved characteristics of external respiration throughout the study period. Strategy 3 was associated with a decrease in the external respiration function and the level of control.

  15. MicroRNA and bronchial asthma%MicroRNA与支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    徐晶; 李满祥

    2012-01-01

    MicroRNA是一类单链小分子RNA,在各个物种间具有高度的保守性.MicroRNA的主要功能是在转录后水平调节相关基因表达,进而对机体生长、发育以及疾病发生过程进行调控.支气管哮喘是一种常见的慢性气道炎症性疾病,其特征是反复发作性喘息、可逆的气道梗阻和气道重塑.近年来,MicroRNA在支气管哮喘发病过程中的调控机制日益引起研究者们的重视.本文就近年来MicroRNA在支气管哮喘发病机制方面的研究进行综述.%MicroRNA (miRNA) are a class of small non-coding single-stranded RNAs with highly conserved sequences among different species,which play an important role in the regulation of genes expression post-transcriptionally,they also modulate growth of cells and development of organs.Bronchial asthma is a common chronic inflammatory disease of the airway characterized by recurring symptoms,reversible airflow obstruction and airway remodeling. Recently it has been shown that miRNA were associated with the development of bronchial asthma.This review of miRNA outlines and analyzes the role of miRNA inthe pathogenesis of bronchial asthma.

  16. BRONCHOSCOPIC THERAPY IN PATIENTS WITH INTRALUMINAL TYPICAL BRONCHIAL CARCINOID

    NARCIS (Netherlands)

    SUTEDJA, TG; SCHREURS, AJ; VANDERSCHUEREN, RG; KWA, B; VANDERWERF, TS; POSTMUS, PE

    1995-01-01

    Objective: To study the efficacy of bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid. Design: Retrospective analysis of the data of patients with bronchial carcinoid, treated primarily with bronchoscopic techniques such as Nd-YAG laser in various hospitals in the Nethe

  17. Sleep Disorders in Patients with Bronchial Asthma

    OpenAIRE

    Cukic, Vesna; Lovre, Vladimir; Dragisic, Dejan

    2011-01-01

    Respiratory disturbances during sleep are recognized as extremely common disorders with important clinical consequences. Breathing disorders during sleep can result in broad range of clinical manifestations, the most prevalent of which are unrefreshing sleep, daytime sleepiness and fatigue, and cognitive impairmant. There is also evidence that respiratory-related sleep disturbances can contribute to several common cardiovascular and metabolic disorders, including systemic hypertension, cardia...

  18. Cost-Effectiveness of Bronchial Thermoplasty, Omalizumab, and Standard Therapy for Moderate-to-Severe Allergic Asthma.

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    Zafar Zafari

    Full Text Available Bronchial thermoplasty (BT is a recently developed treatment for patients with moderate-to-severe asthma. A few studies have suggested the clinical efficacy of this intervention. However, no study has evaluated the cost-effectiveness of BT compared to other alternative treatments for moderate-to-severe allergic asthma, which currently include omalizumab and standard therapy.To evaluate the cost-effectiveness of standard therapy, BT, and omalizumab for moderate-to-severe allergic asthma in the USA.A probabilistic Markov model with weekly cycles was developed to reflect the course of asthma progression over a 5-year time horizon. The study population was adults with moderate-to-severe allergic asthma whose asthma remained uncontrolled despite using high-dose inhaled corticosteroids (ICS, with or without long-acting beta-agonists [LABA]. A perspective of the health-care system was adopted with asthma-related costs as well as quality-adjusted life years (QALYs and exacerbations as the outcomes.For standard therapy, BT, and omalizumab, the discounted 5-year costs and QALYs were $15,400 and 3.08, $28,100 and 3.24, and $117,000 and 3.26, respectively. The incremental cost-effectiveness ratio (ICER of BT versus standard therapy and omalizumab versus BT was $78,700/QALY and $3.86 million/QALY, respectively. At the willingness-to-pay (WTP of $50,000/QALY and $100,000/QALY, the probability of BT being cost-effective was 9%, and 67%, respectively. The corresponding expected value of perfect information (EVPI was $155 and $1,530 per individual at these thresholds. In sensitivity analyses, increasing the costs of BT from $14,900 to $30,000 increased its ICER relative to standard therapy to $178,000/QALY, and decreased the ICER of omalizumab relative to BT to $3.06 million/QALY. Reducing the costs of omalizumab by 25% decreased its ICER relative to BT by 29%.Based on the available evidence, our study suggests that there is more than 60% chance that BT becomes

  19. Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide

    DEFF Research Database (Denmark)

    Bisgaard, H; Damkjaer Nielsen, M; Andersen, B;

    1988-01-01

    The effect of inhaled beclomethasone dipropionate and budesonide on the adrenal function was studied in 30 children (aged 7 to 15 years) with mild bronchial asthma. The trial was designed as a prospective double-blind parallel study of the effect of stepwise increase of either beclomethasone...... difference was found between the two topical steroids (probability value 5.3%), and yet the suppression was apparent in the group of children treated with beclomethasone dipropionate but not in the group of children treated with budesonide. Further studies are desirable in order to ascertain whether...

  20. Effect of Azithromycin on Function of Peripheral Blood Dendritic Cells in Children with Bronchial Asthma

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    Xuan WANG

    2017-03-01

    Full Text Available Objective: To observe the effect of azithromycin on the function of dendritic cells (DCs originated from peripheral blood mononuclear cells (PBMCs in children with bronchial asthma so as to explore the action mechanism of azithromycin in immunoregulation.Methods: Totally 32 children with bronchial asthma were selected as observation group, and 30 healthy children through physical examination as control group. Under sterile condition, PBMCs were prepared using density gradient centrifugation, and DCs were induced by recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF and recombinant human interleukin-4 (rhIL-4 in vitro. Observation group was intervened by different concentrations of azithromycin (0.0, 0.1 and 10.0 mg/L, while control group didn’t receive any intervention. The expression rates of CD80, CD83 and CD86 on the surface of DCs were detected using flow cytometry, and the levels of IL-10 and IL-12 in the cultured supernate were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA.Results: The expression rate of CD86 was significantly higher, whereas the levels of IL-10 and IL-12 were markedly lower in observation group than in control group, and the differences were statistically significant (P<0.05 or P<0.01. In observation group, the level of IL12 was positively correlated with that of IL-10 (r=0.736, P<0.01, but no correlation was shown between the levels of IL-10 and IL-12 in control group (r=0.228, P>0.05. Significant difference was not shown by comparison to the expression rates of CD83, CD80 and CD86 on the surface of DCs intervened by azithromycin at 0.0, 0.1 and 10.0 mg/L (P>0.05. The levels of IL-10 at 0.1 and 10.0 mg/L were dramatically lower than that at 0.0 mg/L (P<0.01, and the level of IL-12 at 0.1 mg/L was notably lower than those at 0.0 and 10.0 mg/L (P<0.01.Conclusion: DCs in children with bronchial asthma are imperfect, and are mainly marked by increase of CD86

  1. EFFECTS OF ORAL HYGIENE UPON THE QUALITY OF BREATHING IN CHILDREN SUFFERING FROM BRONCHIAL ASTHMA

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    Mona Olar

    2012-09-01

    Full Text Available In Romania, bronchial asthma represents a major public health problem. SCOPE: The study discusses the effects of bacterial plaque control upon the quality of respiration in a group of ashtmatic children previously subjected to professional dental scaling and brushing, comparatively with a similar group, whose habits of oral hygiene had not been influenced. In both groups, the indices of bacterial plaque and gingival bleeding were calculated, respiratory functional samples were taken, the number of eosinophylls, the concentration of seric IgE and salivary sIgA were analyzed, and bacterial concentration and morphology of the dental plaque were determined. Statistically, the quality of respiration has been significantly improved in the children whose dental plaque had been controlled. Correlations have been evidenced among asthma symptomatology, indices of oral health, immunological markers and the bacterial profile of the dental plaque.

  2. Resting and post bronchial challenge testing carbon dioxide partial pressure in individuals with and without asthma.

    Directory of Open Access Journals (Sweden)

    David Miedinger

    Full Text Available OBJECTIVE: There is conflicting evidence about resting carbon dioxide levels in asthmatic individuals. We wanted to determine if transcutaneously measured carbon dioxide levels prior and during bronchial provocation testing differ according to asthma status reflecting dysfunctional breathing. METHODS: We investigated active firefighters and policemen by means of a validated questionnaire on respiratory symptoms, spirometry, bronchial challenge testing with methacholine (MCT and measurement of transcutaneous blood carbon dioxide partial pressure (PtcCO(2 at rest prior performing spirometry, one minute and five minutes after termination of MCT. A respiratory physician blinded to the PtcCO(2 results assigned a diagnosis of asthma after reviewing the available study data and the files of the workers medical screening program. RESULTS: The study sample consisted of 128 male and 10 female individuals. Fifteen individuals (11% had physician-diagnosed asthma. There was no clinically important difference in median PtcCO(2 at rest, one and five minutes after recovery from MCT in asthmatics compared to non-asthmatics (35.6 vs 35.7 mmHg, p = 0.466; 34.7 vs 33.4 mmHg, p = 0.245 and 37.4 vs 36.4 mmHg, p = 0.732. The median drop in PtcCO(2 during MCT and the increase after MCT was lower in asthmatics compared to non-asthmatics (0.1 vs 3.2 mmHg, p = 0.014 and 1.9 vs 2.9 mmHg, p = 0.025. CONCLUSIONS: PtcCO(2 levels at rest prior and during recovery after MCT do not differ in individuals with or without physician diagnosed asthma. The fall and subsequent increase in PtcCO(2 levels are higher in non-asthmatics than in asthmatics and seems to be related with increased number of respiratory maneuvers during MCT.

  3. 广东惠州地区成人支气管哮喘合并过敏性鼻炎的流行病学调查分析%Epidemiology analysis of patients with bronchial asthma combined with allergic rhinitis in Huizhou

    Institute of Scientific and Technical Information of China (English)

    吴峰; 林伟明; 陈宫玉; 陈钊成; 陈必达; 周五铁; 吴思仿; 吴海桂

    2012-01-01

    Objective To study the status of bronchial asthma (asthma) in patients with allergic rhinitis in Huizhou,and to analyze the correlation of clinical characteristic between allergic rhinitis and bronchial asthma,to investigate the patients' cognitions and treatment situation about the allergic rhinitis.Methods The questionnaire survey of 280 cases of asthma in Huizhou,their medical history,severity,asthma control test (ACT) were investigated in details.The rhinitis survey included prevalence,cognition,family history and treatment situation.The patients,data were collected and analyzed.Results In 280 cases of bronchial asthma,203 cases(72.5%) combined with allergic rhinitis.There was no statistical significance ( P >0.05) between the group of asthma combined with allergic rhinitis and the group of simple asthma on the age,sex,and the disease course.Compared with the group of simple asthma on case,the group of asthma combined with allergic rhinitis were more cases at the grade 2(mild persistence),grade 3(moderate persistence),and grade 4 (severe persistence),and few cases in complete control,good control through ACT ( P <0.05),while more cases in the uncontrol through ACT ( P <0.05).Allergic rhinitis:in the the group of asthma combined with allergic rhinitis,there were 59.61% of the patients got allergic rhinitis earlier than asthma,about 17.24% got those two disease at the same time.The inducements of allergic rhinitis were cold air (82.10%),irritant gas (61.58%),about 25.62% patients had been allergen tested,56.65 % patients had used drug treatment.27.10 % patients had family history of asthma or allergic rhinitis.Conclusions The morbidity of asthma combining with allergic rhinitis is high in Huizhou city,the cognition is low,and treatment status are not optimistic,which can be the basis of prevention and treatment in future.%目的 了解惠州地区支气管哮喘(简称哮喘)患者合并过敏性鼻炎的情况,分析两者在临床表现

  4. Bronchial asthma and autophagy%支气管哮喘与细胞自噬

    Institute of Scientific and Technical Information of China (English)

    马龙艳; 吴琦

    2016-01-01

    近年来,随着人们对细胞生物学、遗传学研究的不断深入,细胞自噬在支气管哮喘(以下简称为哮喘)中的作用日趋明朗,特别在遗传因素、氧化应激和环境等方面,自噬调控可能直接影响哮喘的发生和发展,这将有望成为哮喘治疗的新方向.本文就细胞自噬、细胞自噬与哮喘的关系进行论述.%In recent years, with the further study of cell biology and genetics, the role of autophagy in bronchial asthma is becoming more and more obvious. Especially in the aspects of genetic factors, oxidative stress and environment, autophagy regulation may directly affect the occurrence and development of asthma, which may become a new direction of asthma treat-ment. In this review we will discuss what is autophagy, and the relationship between autophagy and asthma.

  5. Oxidative Stress and Bronchial Asthma in Children—Causes or Consequences?

    Directory of Open Access Journals (Sweden)

    Milos Jesenak

    2017-07-01

    Full Text Available Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation. It is evident that asthma is accompanied by oxidative stress in the airways and in the systemic circulation. The oxidative stress is more pronounced during the acute exacerbation or allergen challenge. On the other hand, the genetic variations in the genes for anti-oxidative and pro-oxidative enzymes are variably associated with various asthmatic subtypes. Whether oxidative stress is the consequence of, or the cause for, chronic changes in asthmatic airways is still being discussed. Contribution of oxidative stress to asthma pathology remains at least partially controversial, since antioxidant interventions have proven rather unsuccessful. According to current knowledge, the relationship between oxidative stress and asthmatic inflammation is bidirectional, and genetic predisposition could modify the balance between these two positions—oxidative stress as a cause for or consequence of asthmatic inflammation.

  6. DNA methylation and bronchial asthma%DNA甲基化与支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    徐礼; 向旭东

    2015-01-01

    Bronchial asthma (asthma) is a chronic inflammatory disease of the airways.In the pathogenesis of asthma,epigenetics links the environmental factors and genetic susceptibility,interrupting the differentiation and function of the immune system,thus contributing to the occurrence of asthma.DNA methylation is known as the most common form of epigenetics.Food and environmental factors affect the differentiation of CD4+ T cells among the cellular components of asthma by DNA methylation.Maternal prenatal consumption of diet rich in methyl donors,and inhalation of risk factors in the environment can affect DNA methylation in CD4+ T cells in vivo,resulting in "Th2 polarization" and promoting the disease of asthma.%支气管哮喘(简称哮喘)是一种气道慢性炎症性疾病,在哮喘的发病机制中,表观遗传学是联系环境因素与遗传易感因素之间的纽带,导致机体免疫系统的发育及功能紊乱,从而促进哮喘的发生.DNA甲基化作为最常见的表观遗传修饰形式,食物与环境因素通过DNA甲基化产生对哮喘细胞学组分CD4+T细胞分化的影响.母体产前食用富含甲基供体饮食,吸入环境中的危险因子均可影响CD4+T细胞在体内的DNA甲基化,导致“Th2极化”,促进哮喘的发生.

  7. Studies on platelet function in bronchial asthma Part 2. Production of 12-hydroxyeicosatetraenoic acid from platelets and the platelet-lymphocyte interaction in bronchial asthmatics

    OpenAIRE

    角南, 宏二

    1992-01-01

    To clarify the role of platelets in the pathogenesis of bronchial asthma, the production of 12-hydroxyeicosatetraenoic acid(12HETE) from platelets of asthmatics was examined by high performance liquid chromatography(HPLC). The effect of platelets on lymphocyte function was also studied by lymphocyte blastogenesis. The results were as follows : 1) The production of 12HETE from platelets of asthmatics were significantly higher than that of normal subjects(p

  8. 80例支气管哮喘患者中医体质分布特点及其与证候的关系%Distribution characteristics of TCM constitutional types in 80 patients with bronchial asthma and relationships between these characteristics and syndromes

    Institute of Scientific and Technical Information of China (English)

    耿嘉玮; 乔会秀

    2012-01-01

    Objective To explore the characteristics of TCM constitution of 80 patients with bronchial asthma and study the relation between constitutions and syndromes, to provide basis for preventing and treating bronchial asthma. Methods Constitution questionnaires and coronary angiography were used to survey 80 patients withbronchial asthma. Constitutions were analyzed and diagnosed based on WANG Qi s Constitutional Classification. The correlation between constitution and syndrome was analyzed. Results In 80 bronchial asthma cases, the pathological constitutional types are mostly phlegm-dampness constitution, followed by Qi deficiency constitution, allergic constitution, dampness-heat constitution, Yang deficiency constitution. Yin deficiency constitution, Qi stagnation constitution, blood stasis constitutionin sequence. The syndrome types are mostly Lung deficiency Syndrome, Spleen Deficiency Syndrome and phlegm-dampness Syndrome, Lung deficiency Syndrome was correlated significantly to phlegm-dampness constitution, Qi deficiency constitution, allergic constitution; Spleen Deficiency Syndrome was correlated significantly to phlegm-dampness constitution, Qi deficiency constitution, allergic constitution; Spleen Deficiency Syndrome was correlated significantly to phlegm-dampness constitution, allergic constitution; with phlegm-dampness Syndrome was correlated significantly to phlegm-dampness constitution, Qi deficiency constitution, blood stasis Syndrome was correlated significantly to blood stasis constitution. Conclusion The most common constitutions are phlegm-dampness constitution, Qi deficiency constitution, allergic constitution. There is close correlation between TCM constitution and syndrome of patients with bronchial asthma.%目的 调查80例支气管哮喘患者中医体质类型,研究体质类型与证候分型的关系,为支气管哮喘的中医防治提供依据.方法 对80例支气管哮喘患者采用中医体质问卷进行中医体质调查,并按照

  9. A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells.

    Science.gov (United States)

    Martinez-Nunez, Rocio T; Bondanese, Victor P; Louafi, Fethi; Francisco-Garcia, Ana S; Rupani, Hitasha; Bedke, Nicole; Holgate, Stephen; Howarth, Peter H; Davies, Donna E; Sanchez-Elsner, Tilman

    2014-01-01

    MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now growing evidence that they can work in co-operative networks. MicroRNAs are known to be dysregulated in many diseases and affect pathways involved in the pathology. We investigated dysregulation of microRNA networks using asthma as the disease model. Asthma is a chronic inflammatory disease of the airways characterized by bronchial hyperresponsiveness and airway remodelling. The airway epithelium is a major contributor to asthma pathology and has been shown to produce an excess of inflammatory and pro-remodelling cytokines such as TGF-β, IL-6 and IL-8 as well as deficient amounts of anti-viral interferons. After performing microRNA arrays, we found that microRNAs -18a, -27a, -128 and -155 are down-regulated in asthmatic bronchial epithelial cells, compared to cells from healthy donors. Interestingly, these microRNAs are predicted in silico to target several components of the TGF-β, IL-6, IL-8 and interferons pathways. Manipulation of the levels of individual microRNAs in bronchial epithelial cells did not have an effect on any of these pathways. Importantly, knock-down of the network of microRNAs miR-18a, -27a, -128 and -155 led to a significant increase of IL-8 and IL-6 expression. Interestingly, despite strong in silico predictions, down-regulation of the pool of microRNAs did not have an effect on the TGF-β and Interferon pathways. In conclusion, using both bioinformatics and experimental tools we found a highly relevant potential role for microRNA dysregulation in the control of IL-6 and IL-8 expression in asthma. Our results suggest that microRNAs may have different roles depending on the presence of other microRNAs. Thus, interpretation of in silico analysis of microRNA function should be confirmed experimentally in the relevant cellular context taking into account interactions with other micro

  10. A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells.

    Directory of Open Access Journals (Sweden)

    Rocio T Martinez-Nunez

    Full Text Available MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now growing evidence that they can work in co-operative networks. MicroRNAs are known to be dysregulated in many diseases and affect pathways involved in the pathology. We investigated dysregulation of microRNA networks using asthma as the disease model. Asthma is a chronic inflammatory disease of the airways characterized by bronchial hyperresponsiveness and airway remodelling. The airway epithelium is a major contributor to asthma pathology and has been shown to produce an excess of inflammatory and pro-remodelling cytokines such as TGF-β, IL-6 and IL-8 as well as deficient amounts of anti-viral interferons. After performing microRNA arrays, we found that microRNAs -18a, -27a, -128 and -155 are down-regulated in asthmatic bronchial epithelial cells, compared to cells from healthy donors. Interestingly, these microRNAs are predicted in silico to target several components of the TGF-β, IL-6, IL-8 and interferons pathways. Manipulation of the levels of individual microRNAs in bronchial epithelial cells did not have an effect on any of these pathways. Importantly, knock-down of the network of microRNAs miR-18a, -27a, -128 and -155 led to a significant increase of IL-8 and IL-6 expression. Interestingly, despite strong in silico predictions, down-regulation of the pool of microRNAs did not have an effect on the TGF-β and Interferon pathways. In conclusion, using both bioinformatics and experimental tools we found a highly relevant potential role for microRNA dysregulation in the control of IL-6 and IL-8 expression in asthma. Our results suggest that microRNAs may have different roles depending on the presence of other microRNAs. Thus, interpretation of in silico analysis of microRNA function should be confirmed experimentally in the relevant cellular context taking into account interactions

  11. Clinical analysis of shortness of breath as the manifestations of anxiety disorder patients misdiagnosed as bronchial asthma%以气促为主诉症状的焦虑症患者误诊为支气管哮喘临床分析

    Institute of Scientific and Technical Information of China (English)

    陈庆; 陈丽娟; 刘跃建

    2015-01-01

    Objective To retrospectively analyze the reason of 41 patients who had shortness of breath and pant misdiagnosed as bronchial asthma. Methods According to patients′complaints, symptoms, bronchial provoca-tion tests, and responses to treatment for asthma, they were preliminary diagnosed as bronchial asthma. At the same time, they were asked to fill in asthma control test ( ACT) scale, self-rating depression scale ( SDS) and Self rating anxiety scale ( SAS) under the guidance of the psychosomatic department specialist. All of them were followed-up for 3 months. The correlations among ACT, SDS and SAS scores were analyzed. Results There were 41 female patients (95%). The scores of ACT, SDS and SAS improved significantly after the related treatment (P<0. 05). The lon-gest follow-up was 12 months, and there was no death caused by asthma attack during follow-up. Conclusion The shortness of breath as the chief complaint of anxiety patients is easily misdiagnosed as asthma, especially in female patients. Rational use of ACT, SDS, SAS and other ratings can reduce the rate of misdiagnosis.%目的:回顾性分析在我院就诊的41例以气促、气喘为主诉症状的焦虑症患者误诊为支气管哮喘的临床特点,分析误诊原因。方法所有患者均由呼吸专科医师在患者就诊时据患者的主诉、体征、支气管激发试验及患者对哮喘相关治疗的反应进行初步判断,填写哮喘控制测试( ACT)量表,再在心身科专科医师指导下行抑郁自评量表(SDS)及焦虑自评量表(SAS)填写,若诊断为焦虑障碍即予以心身专科抗焦虑治疗。追踪随访3个月以上,对患者治疗前后症状、SDS、SAS、ACT评分进行相关分析。结果41例患者中女性占绝对多数(95%),进行心身科专科治疗后患者气促等临床症状得到明显改善,ACT、SDS、SAS评分均较治疗前明显改善(P<0.05)。最长随访为12月,部分患者虽有气促、胸闷症状的反复发作,但在心身科调

  12. 支气管哮喘诊疗新进展%New progresses of diagnoses and treatments of bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    王林林; 时国朝

    2012-01-01

    The diagnoses and treatments of bronchial asthma has being made great progresses mainly in improvements of traditional drugs,new drugs and new methods of diagnoses due to intensive studies of causes and pathogeneses of bronchial asthma.Progresses mainly include the analyses of exhaled nitric oxide and exhaled breath condensate,bronchial thermoplasty,monoclonal anti-IgE antibody and so on.%随着对支气管哮喘病因和发病机制的深入研究,其诊疗方法取得了很大的进展,表现在传统药物的新进展以及新的药物和诊断方法的出现,主要有呼出气一氧化氮检测、呼出气冷凝液分析、支气管热成型疗法、抗IgE单克隆抗体等.

  13. Investigation and analysis of hospitalized patients with bronchial asthma onset in Qinghai University Hospital%青海大学附属医院住院支气管哮喘患者发病情况的调查与分析

    Institute of Scientific and Technical Information of China (English)

    陈俊梅; 高芬

    2008-01-01

    Objective To investigate the incidence and clinical characteristics of hospitalized patients with bronchial asthma who live in Qinghai University Hospital,Xining City. Methods Confirmed eases of bronchial asthma from respiratory medicine of Qinghai University Affiliated Hospital are reviewed. Results There were 70 eases of asthma from the respiratory medicine during five years and this number was 2.40%of the total hospitalized patients. Asthma mostly attacked on the April and August, and the temperature plunged and respiratory tract infections were the most common predisposing factors. Respiratory symptoms mostly suddenly attacked,and the attack was erratic. The investigation asthma patients were all in the acute stage,and the illness was mainly light to moderate. 69.09%of patients were with normal body mass index.Conclusions The prevalence of asthma in Xining city is lower than in low altitude areas in China,and asthma was less severe disease. The reasons for this phenomenon are related with Xining hypobaric hypoxia and the characteristics of the climate. There are no significant correlations between asthma attack and obesity, ethnic.%目的 调查地处高原的西宁市青海大学附属医院住院支气管哮喘(简称哮喘)患者的发病情况及临床特点.方法 对我院呼吸科收住的哮喘确诊病例进行回顾性调查和分析.结果 5年间我院呼吸科共收住哮喘患者70例,占同期呼吸科住院患者总数的2.40%,31~50岁为高发年龄段,女性多见,农民为好发职业.哮喘发作集中在4月和8月,气温骤降和呼吸道感染是最常见的发病诱因,呼吸道症状多突然发作,且呈发作性,发作时间无规律.所调查的哮喘患者均处于急性发作期,病情以轻、中度为主,69.09%的患者体质量指数正常.结论 本资料中哮喘患病率较我国低海拔地区低,且哮喘发病程度较轻,这与西宁地区低压低氧及其气候特点有关.同时未见哮喘患病与肥胖和民族有明显相关性.

  14. Intervention effect by solution focused approach for anxiety, depression and quality of life in bronchial asthma patients%聚焦解决模式对支气管哮喘患者焦虑、抑郁及生活质量的干预作用

    Institute of Scientific and Technical Information of China (English)

    戚雯雯; 刘红琰

    2016-01-01

    目的:评价聚焦解决模式对支气管哮喘患者焦虑、抑郁及生活质量的干预作用。方法200例支气管哮喘患者,随机分为实验组和对照组,各100例。对照组患者给予常规护理干预,实验组患者在常规护理干预的基础上给予聚焦解决模式的心理干预。干预前后利用焦虑自评量表(SAS)、抑郁自评量表(SDS)和哮喘生活质量调查量表(AQLQ)分别评价和比较两组患者的焦虑、抑郁状态和生活质量。结果经过聚焦解决模式的心理干预后,实验组患者的焦虑、抑郁评分低于对照组,差异有统计学意义(P<0.01),实验组患者 AQLQ 中日常生活受限、伴随症状、不适感、对诱发因素的反应、对哮喘的心理反应等5个维度的评分及总分均高于对照组,差异有统计学意义(P<0.01)。结论聚焦解决模式的心理干预可以有效改善支气管哮喘患者焦虑、抑郁状态,提高其生活质量,有利于控制哮喘病情。%Objective To evaluate intervention effect by solution focused approach for anxiety, depression and quality of life in bronchial asthma patients. Methods A total of 200 patients with bronchial asthma were randomly divided into experimental group and control group, with 100 cases in each group. The control group received conventional nursing intervention, and the experimental group received additional solution focused approach for psychological intervention. Self-rating anxiety scale (SAS), self-rating depression scale (SDS), and asthma quality of living questionnaire (AQLQ) were applied to evaluate and compare anxiety, depression and quality of life in the two groups before and after intervention. Results After solution focused approach for psychological intervention, the experimental group had lower scores of anxiety and depression than the control group, and the difference had statistical significance (P<0.01). It also had higher scores of limited daily life, simultaneous

  15. The Effect of Montelukast on the Levels of IL-6,IL-8 and IL-10 in Patients with Bronchial Asthma%孟鲁司特对支气管哮喘患者血清IL-6、IL-8和IL-10水平的影响

    Institute of Scientific and Technical Information of China (English)

    许成

    2012-01-01

    Objective To explore the effect of Montelukaat on serum IL-6,IL-8 and IL-10 levels in patients with bronchial asthma. Methods Serum TL-6,TLS (with RIA) ,IL-10 (with ELISA) levels were measured in 31 patients after Montelukast treatment with bronchial asthma as well as in 35 normal healthy controls. Result Before treatment serum IL-6, IL-8 levels in the asthma group were significantly higher than those in controls (P<0.01). While the IL-10 level was undoubtedly lower than that in the controls (P <0.01). After treatment, the serum IL-6, IL-8 and IL-10 levels were still significantly (P<0.05). Conclusion Montelukast treatment could bring about some regulatory effect on serum IL-6, IL-8 and IL-10 levels in patients with asthma and furthermore reducing the severity of inflammation and enhancing remission.%目的 探讨孟鲁司特在支气管哮喘患者体内IL-6、IL-8和IL-10水平的影响.方法 应用放射免疫分析和酶联法对31例支气管哮喘患者应用孟鲁司特治疗前后血清IL-6、IL-8和IL-10水平的变化,并与35名正常健康人作比较.结果 支气管哮喘患者在治疗前血清IL-6、IL-8水平非常显著地高于正常人组(P<0.01),而IL-10水平显著地低于正常人组(P<0.01),经治疗2周后与正常人组比较仍有显著性差异(P<0.05).结论 孟鲁司特对支气管哮喘患者血清IL-6、IL-8和IL-10有一定程度的调节作用,从而降低患者体内的炎症水平,促进病情缓解和好转.

  16. Type I IL-1 Receptor (IL-1RI as Potential New Therapeutic Target for Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Jyh-Hong Lee

    2010-01-01

    Full Text Available The IL-1R/TLR family has been receiving considerable attention as potential regulators of inflammation through their ability to act as either activators or suppressors of inflammation. Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, allergic inflammation, elevated serum total, allergen-specific IgE levels, and increased Th2 cytokine production. The discovery that the IL-1RI–IL-1 and ST2–IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma. This paper discusses the current use of neutralizing mAb or soluble receptor constructs to deplete cytokines, the use of neutralizing mAb or recombinant receptor antagonists to block cytokine receptors, and gene therapy from experimental studies in asthma. Targeting IL-1RI–IL-1 as well as ST2–IL-33 pathways may promise a disease-modifying approach in the future.

  17. CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS

    Directory of Open Access Journals (Sweden)

    I. A. Kamaeva

    2013-01-01

    Full Text Available  To reveal clinical and immunological features of bronchial asthma (BA combined with thyroid gland pathology,  sixty patients have been examined  in  five equal groups, i.e., BA; hypothyroidism;  thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more  frequently  in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged  in BA patients,  than  in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum  IgE  levels were much  increased  in  the group with BA + hyperthyroidism. The  lowest IL-4/IFNγ ratio was revealed  in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher  in BA + hyperthyroidism group,  than  in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating  in BA, whereas concomitant hypothyroidism may cause  a  reduction of Th2  immune  response.

  18. PRIMARY RESULTS OF LONG-TERM DYNAMIC MONITORING OF CHILDREN WITH BRONCHIAL ASTHMA OF UNCONTROLLED SEVERE PERSISTENT COURSE

    Directory of Open Access Journals (Sweden)

    L. S. Namazova-Baranova

    2016-01-01

    Full Text Available Background. Patients registers help obtain the latest information about the clinical course of a disease, safety and effectiveness of the medical technology. Objective: Our aim was to analyze the efficiency and safety of omalizumab with children suffering from uncontrolled severe persistent bronchial asthma (BA according to the data of the developed register. Methods.  A register of patients with severe asthma of uncontrolled course receiving omalizumab in addition to basic therapy has been developed. Results. Results of treatment of 101 children aged 6–17 have been analyzed. The duration of therapy with omalizumab lasted from 1 to 85 months, with a median of 16 (10; 44 months. The drug was used in doses of 75 to 600 mg, with a median of 300 (225; 375 mg. The therapy with omalizumab allowed achieving a better control of the disease (AST test prior to start of therapy — 14 (11; 17 points, in 1 year — 20 (13; 25; p < 0,001; reduction of the volume of daily base therapy (prior to start of therapy, average dose of inhaled corticosteroids in terms of fluticasone was 629 ± 304 mg (n = 15, in 4 years — 524 ± 342 mg; p = 0.065; reduction of the number of aggravations and the need to use short-effectiv   2-agonists.  No adverse systemic effects of the introduction of genetically engineered biological drugs have been found. Conclusion. Register of patients with severe persistent asthma can be used as a tool for long-term  monitoring and integrated assessment of the efficiency and safety of therapy.

  19. Clinical advances on Bronchial Asthma. Changing perceptions. Avances clínicos en asma bronquial

    Directory of Open Access Journals (Sweden)

    Dianelis Sierra Martínez

    Full Text Available Bronchial Asthma brepresents an important health problem worlwide due to the increment of its incidence in the last years. The general mortality is low in regard to morbidity but it could be potencially lethal. It is consider a frequent disease in our country when it is found in patients older than 15 years old and female sex is more prevalent than the male one. It has influence upon not only the ill person but also in the family ad society. The sanitary education is an important aspect for the correct control of sick patients. Within the following paper it is our intention to update the knowledge about this disease through a bibliographic revision. Epidemiology, physiopathology, classification, complementary explorations, as well as the factors that must be paid attention on its treatment are found among the processed aspects, all which will serve for consultation not only for students but also for professionals of the medical science branch.
    El asma bronquial representa un importante problema de salud en todo el mundo, pues su incidencia se ha incrementado en los últimos tiempos. La mortalidad general es baja en relación a la morbilidad, pero puede ser potencialmente mortal. En nuestro país se considera una enfermedad frecuente, posterior a los 15 años y hay predominio del sexo femenino. Repercute no sólo en el enfermo sino tambien en la familia y en la sociedad. La educación sanitaria es un aspecto importante para el correcto control de los enfermos. Con el presente trabajo se pretende actualizar los conocimientos acerca de esta enfermedad, a través de una revisión bibliográfica. Entre los aspectos tratados se encuentran: la epidemiología, la fisiopatología, la clasificación, las exploraciones complementarias, así como los factores que deben ser atendidos en su tratamiento, todo lo cual servirá para consulta de estudiantes y profesionales de las ciencias médicas.

  20. Neutrophil migration and bronchial asthma%中性粒细胞迁移与支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    李海银; 朱黎明

    2012-01-01

    Bronchial asthma (asthma) is a chronic airway inflammatory disease in which a variety of cells and cellular components participate.The etiology and pathogenesis of asthma is very complex.Recent studies found that neutrophils played an important role in the pathogenesis of asthma.Now the molecular mechanisms of neutrophil migration in asthma are summarized as follows.%支气管哮喘(简称哮喘)是由多种细胞和细胞组分参与的气道慢性炎症性疾病,其病因及发病机制十分复杂.近年来研究发现中性粒细胞在其发病机制中起重要作用,现就其迁移的分子机制在哮喘中的作用进行综述如下.

  1. Evaluation of Differentiated Human Bronchial Epithelial Cell Culture Systems for Asthma Research

    Directory of Open Access Journals (Sweden)

    Ceri E. Stewart

    2012-01-01

    Full Text Available The aim of the current study was to evaluate primary (human bronchial epithelial cells, HBEC and non-primary (Calu-3, BEAS-2B, BEAS-2B R1 bronchial epithelial cell culture systems as air-liquid interface- (ALI- differentiated models for asthma research. Ability to differentiate into goblet (MUC5AC+ and ciliated (β-Tubulin IV+ cells was evaluated by confocal imaging and qPCR. Expression of tight junction/adhesion proteins (ZO-1, E-Cadherin and development of transepithelial electrical resistance (TEER were assessed. Primary cells showed localised MUC5AC, β-Tubulin IV, ZO-1, and E-Cadherin and developed TEER with, however, a large degree of inter- and intradonor variation. Calu-3 cells developed a more reproducible TEER and a phenotype similar to primary cells although with diffuse β-Tubulin IV staining. BEAS-2B cells did not differentiate or develop tight junctions. These data highlight the challenges in working with primary cell models and the need for careful characterisation and selection of systems to answer specific research questions.

  2. Asthma in patients with psoriasis

    DEFF Research Database (Denmark)

    Lønnberg, A S; Skov, L; Skytthe, A;

    2015-01-01

    We read with interest the report by Fang and colleagues of the relationship between psoriasis and asthma in a large retrospective case-control study from Taiwan [1]. The study found a 1.38-fold increased risk of asthma among patients with psoriasis, and with an increasing risk according to higher...

  3. Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.

    Science.gov (United States)

    Carlini, Federico; Picard, Christophe; Garulli, Céline; Piquemal, David; Roubertoux, Pierre; Chiaroni, Jacques; Chanez, Pascal; Gras, Delphine; Di Cristofaro, Julie

    2017-01-01

    Not all asthmatic patients adequately respond to current available treatments, such as inhaled corticosteroids or omalizumab(®). New treatments will aim to target the bronchial epithelium-immune response interaction using different pathways. HLA-G is involved in immunomodulation and may promote epithelial cell differentiation and proliferation. HLA-G protein has several isoforms generated by alternative splicing that might have differential functionalities. HLA-G protein expression and genetic polymorphisms have been reported to be associated with asthma. Our hypothesis is that bronchial epithelium from asthmatic patients displays less functional HLA-G isoforms. HLA-G transcriptional isoforms were quantified by real-time PCR in human bronchial epithelium cells (HBEC) grown in air-liquid interface culture obtained from five healthy controls (HC), seven patients with mild asthma (MA), and seven patients with severe asthma (SA). They were re-differentiated, and IL-13 exposure was used as a proxy for a pro-inflammatory cytokine. HLA-G protein expression was assessed by western blot analysis. HLA-G allele was typed by direct sequencing. Our results showed that both MA and SA display less functional HLA-G isoforms than HC (p G*01:06 frequency in MA and SA was significantly higher than in the healthy population (p = 0.03 and p G expression. Our results support that an impaired expression of HLA-G isoforms in asthmatic patients could contribute to the loss of inflammation control and epithelium structural remodeling. Therefore, HLA-G might be an interesting alternative target for asthmatic patients not adequately responding to current drugs.

  4. Psychological analysis and nursing measures of bronchial asthma%支气管哮喘的心理分析及护理措施

    Institute of Scientific and Technical Information of China (English)

    徐碧辉

    2013-01-01

    目的:探讨支气管哮喘的心理分析及护理措施。方法:对2012年1月~2013年1月我院收治的68例支气管哮喘患者进行心理分析,并给予相应的心理护理措施。结果:患者主要心理特征包括紧张恐惧、孤独悲观、自卑自责及依赖等,通过心理护理干预,恢复情况基本良好。结论:根据支气管哮喘患者的心理特点采取相应的心理护理措施,能够有效控制患者病情的发展。%Objective:to study the psychological analysis of bronchial asthma and nursing measures.Methods:between January 2012 and January 2013, our hospital 68 cases of bronchial asthma patients with psychological analysis,and gives the corresponding psychological nursing intervention.Result:patients were the main psychological characteristics include intense fear,lonely pessimistic,inferiority remorse and rely on,through psychological nursing intervention,the basic good recovery.Conclusion:according to the psychological characteristics of patients with bronchial asthma corresponding psychological nursing measures,can ef-fectively control the development of the patients.

  5. 30例支气管哮喘的临床治疗分析%Clinical Treatment Analysis of 30 Cases of Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    赫英红

    2016-01-01

    Objective To discuss and analyze the clinical treatment of bronchial asthma. Methods 30 cases of bronchial asthma in our hospital from September 2014 to August 2015 were retrospectively analyzed. Results After the treatment of our hospital, 30 cases of 14 patients with the disease were effectively controlled, 16 cases of the disease were partially controlled. None of the patients died after treatment, but there were 1 cases of pneumothorax, 1 cases of emphysema, 2 cases of pulmonary heart disease. Conclusion In the treatment of bronchial asthma in a scientiifc and reasonable way, for the speciifc circumstances of patients for treatment, can effectively improve the treatment effect.%目的:讨论并分析支气管哮喘的临床治疗方法。方法选取2014年9月~2015年8月,在我院收治的30例支气管哮喘患者,对其治疗方法及病理进行回顾性分析。结果经过我院的系统治疗,30例患者中14例病情得到有效控制,16例病情得到部分控制。所有患者经治疗后无人死亡,但其中并发气胸1例,肺气肿1例,肺心病2例。结论在治疗支气管哮喘时运用科学、合理的方式,针对患者具体情况进行治疗,可有效的提升治疗效果。

  6. Correlation between daily spirometry and asthma control test in patients with various symptom perception types of bronchial asthma%动态肺功能测试与哮喘控制测试不同症状感知类型支气管哮喘患者的相关性研究

    Institute of Scientific and Technical Information of China (English)

    颜文森; 郑劲平; 高怡; 韩江娜; 安嘉颖

    2013-01-01

    目的 通过动态肺功能测试与哮喘控制测试(asthma control test,ACT)评分对不同症状感知类型的支气管哮喘(以下简称哮喘)进行研究,探讨ACT在临床使用的准确性.方法 对42例不同症状感知类型哮喘患者在动态肺功能监测前和监测期间(第14天)各进行一次ACT问卷调查.同时每天用动态肺量记录仪测定肺功能,连续监测14天,对监测前和监测期间不同症状感知类型哮喘患者的ACT评分和第一秒用力肺活量占预计值百分比(FEV1%pred)进行相关性分析.结果 42例患者ACT评分与FEV1%pred进行相关分析发现,监测前和监测期间两者均存在相关性(前:r=0.317,P<0.05;期间:r=0.360,P< 0.05).症状感知正常型哮喘患者在监测前和监测期间两次ACT评分与FEV1%pred之间均存在显著相关性(前:r=0.647,P<0.01;期间:r=0.698,P<0.01).而迟钝型和敏感型ACT评分与FEV1%pred之间均不存在相关性,其中迟钝型(前:r=-0.453,P>0.05;期间:r=0.468,P>0.05),敏感型(前:r=0.487,P>0.05;期间:r=0.253,P>0.05).结论 ACT是一种简易有效的评价哮喘控制的方法,与症状感知正常的哮喘患者肺功能具显著的相关性和一致性,但ACT在症状感知迟钝型和敏感型哮喘患者控制水平的测试效能和准确性较低,容易出现偏差,使用前应考虑受试者的依从性及症状感知是否正常.%Objective Patients with asthma could present various symptom perception types.Aim of the study is to investigate the characteristics of the symptom perception types of bronchial asthma by using daily spirometry and Asthma Control Test (ACT) in order to determine the accuracy ACT in clinical use.Methods A cohort of 42 asthmatics with various symptom perception types received ACT questionnaire prior to and on the 14th day lung of function monitoring program in which portable spirometer was used for dynamic recording for 14 days.Correlation between ACT score and lung function

  7. Bronchial asthma healthcare costs in Mexico: analysis of trends from 1991-1996 with information from the Mexican Institute of Social Security.

    Science.gov (United States)

    Rico-Méndez, F G; Barquera, S; Cabrera, D A; Escobedo, S; Ochoa, L G; Massey-Reynaud, L F

    2000-01-01

    Cost trends for bronchial asthma have not been previously estimated in Mexico. The increasing prevalence of bronchial asthma as well as its elevated costs make it necessary to expand the availability of information for health planners. This is a growing problem which has been given little attention in national health reports. We did a descriptive, retrospective analysis using national data from the Mexican Institute for Social Security. We estimated the number of medical consultations provided by the state family medicine and specialty areas. A total of 756,843 consultations due to bronchial asthma were provided between 1991 and 1996 in the service areas under study. The healthcare expenditure for bronchial asthma showed an ascending and sustained trend during the study period. When analyzing the trends by type of service, a significant increase in in-hospital care was observed, ranging from US $14.5 (1991) to $19.8 (1996) million and a maximum of $28.4 (1994) million. A similar increase was found in specialty consultation, from $3.96 (1991) to $8.5 (1996) million; in emergencies, from $1. 1 (1991) to $2.9 (1996) million; and family medicine, from $0.66 (1991) to $0.79 (1996) million. Bronchial asthma follows the same pattern as other noncommunicable chronic diseases, increasing in highly urbanized areas and nationwide. In order to improve healthcare and maximize results with scarce resources, a set of strategies is presented to reduce bronchial asthma recurrence, decrease healthcare costs, and improve quality of life.

  8. Chronic rhinosinusitis and bronchial asthma%慢性鼻-鼻窦炎对支气管哮喘的影响

    Institute of Scientific and Technical Information of China (English)

    戴伟; 辛晓峰

    2014-01-01

    上下呼吸道炎症反应密切相关,慢性鼻-鼻窦炎和支气管哮喘(简称哮喘)分别作为上、下呼吸道的常见疾病,发病率高.慢性鼻-鼻窦炎的患者往往较易罹患哮喘,而有效治疗慢性鼻-鼻窦炎可以改善哮喘症状.本文就慢性鼻-鼻窦炎对哮喘的影响作一综述.%The upper airway inflammation is closely related to the lower airway inflammation,chronic rhinosinusitis and bronchial asthma (asthma) with a high incidence which as a common disease of the upper and lower respiratory tract.Patients who have chronic rhinosinusitis have a higher prevalence of asthma,and effective treatment of chronic rhinosinusitis can improve the symptoms of asthma.In this paper,the impact of chronic rhinosinusitis on asthma is discussed.

  9. Inhaling β2 -agonist with heliox-driven in bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    解立新; 刘又宁; 陈良安; 郝凤英; 金桂清; 赵会泽

    2003-01-01

    Objective To evaluate the effectiveness of a helium-oxygen mixture (79%He- 21%O2) as an aerosolizing compressed gas for β2-agonist therapy in patients with an asthma exacerbation. Methods Twenty-four patients in the outpatient department with a mild to moderate exacerbation of asthma were enrolled. The patients were randomly divided into an experimental group (13 cases) and a control group (11 cases). The experimental group inhaled Berotec with heliox-driven, and the control group inhaled Berotec with compressed air-driven. Eight hospitalized patients in the respiratory department with severe exacerbation of asthma were enrolled. The patients inhaled Berotec with heliox-driven or compressed air-driven in a random order.Results The results of spirometric parameters and arterial blood-gas analysis were measured. In the mild to moderate asthma patients, no statistical differences between the two groups for forced vital capacity (FVC), forced expired volume in one second (FEV1), and expiratory flow in 50% forced vital capacity (FEF50) were presented. But the severe patients showed significant differences between heliox-driven and compressed air-driven for FVC, FEV1, FEF50 and partial pressure of oxygen (PaO2). Conclusions Compared with the traditional inhalation of β2-agonist therapy using compressed air-driven, the method of inhaling β2-agonist with heliox-driven has more obvious benefits for those suffering from severe asthma. This is likely due to the cooperative effects between inhaling heliox on its physical gas properties and improving delivery of β2-agonist in the treatment of exacerbation of severe asthma.

  10. The level of specialist assessment of adult asthma is influenced by patient age

    DEFF Research Database (Denmark)

    Porsbjerg, C; Sverrild, A; Stensen, L;

    2014-01-01

    is sparse. AIM: To examine the impact of patient age on the type and proportion of diagnostic tests performed in patients undergoing specialist assessment for asthma. METHODS: Data from a clinical population consisting of all patients consecutively referred over a 12 months period to a specialist clinic...... adults, and were more frequently smokers. However, a regression analysis showed that older age was associated with a lower likelihood of diagnostic assessment with a reversibility test, a bronchial challenge test, or measurement of exhaled NO, independently of a known diagnosis of asthma, smoking habits......BACKGROUND: Late onset asthma is associated with more severe disease and higher morbidity than in younger asthma patients. This may in part relate to under recognition of asthma in older adults, but evidence on the impact of patient age on diagnostic assessment of asthma in a specialist setting...

  11. Application of C-reactive protein detection on senile bronchial asthma and respiratory tract infection in elderly patients%C-反应蛋白检测在老年支气管哮喘与呼吸道感染中的应用研究

    Institute of Scientific and Technical Information of China (English)

    左蕾; 张莹; 拜合提尼沙·吐尔地; 李超; 吴永红

    2016-01-01

    目的:观察 C-反应蛋白(CRP)检测在老年支气管哮喘与呼吸道感染中的诊断价值,为今后临床预防治疗提供参考依据。方法选自2013年2月-2014年3月医院收治的老年支气管哮喘86例,分为哮喘合并细菌感染组45例,哮喘合并病毒感染组41例,另选同期进行健康体检44名健康者作为对照组,观察3组患者 CRP 和血细胞总数情况,数据采用 SPSS 15.0软件进行统计分析。结果细菌感染组患者 C-反应蛋白水平、白细胞总数明显高于病毒感染组及对照组(P <0.05);细菌感染组 C-反应蛋白异常率为93.3%,白细胞异常率为84.4%,明显高于病毒感染组的26.8%、12.2%,差异有统计学意义(P <0.05)。结论血清 C-反应蛋白可作为早期诊断哮喘合并感染的指标之一,其水平高低可反映病情的严重程度,有助于临床鉴别细菌与病毒感染,可为临床用药提供重要参考依据,具有较高应用价值。%OBJECTIVE To observe diagnostic value of C-reactive protein (CRP)detection in senile bronchial chil-dren and respiratory tract infection in elderly patients,so as to provide a reference basis for clinical prevention and treatment in the future.METHODS Eighty six elderly patients with senile bronchial asthma admitted and treated in the hospital from Feb.2013 to Mar.2014 were selected as research subjects,including 45 patients with asthma combined with bacterial infections,and 41 patients suffered from asthma combined with virus infections,and an-other 44 healthy persons undergoing health check-ups during the same period were selected as control group.The total numbers of blood cells of patients in the three groups were observed,and data were analyzed by SPSS 15.0. RESULTS C-reactive protein level and total number of white blood cells of patients in bacterial infection group were significantly higher than those of patients in virus infection group and

  12. Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma

    NARCIS (Netherlands)

    Matsumoto, Hisako; Moir, Lyn M; Oliver, Brian G G; Burgess, Janette K; Roth, Michael; Black, Judith L; McParland, Brent E

    2007-01-01

    BACKGROUND: Exaggerated bronchial constriction is the most significant and life threatening response of patients with asthma to inhaled stimuli. However, few studies have investigated the contractility of airway smooth muscle (ASM) from these patients. The purpose of this study was to establish a me

  13. Association between anti-thyroid peroxidase and anti-cytokeratin 18 autoantibodies and bronchial asthma in women

    Directory of Open Access Journals (Sweden)

    Hala A. Mohammad

    2016-01-01

    Conclusion: Positive anti-TPO autoantibodies and anti-CK18 autoantibodies in asthmatic patients and their higher level in the non-allergic asthma group may strengthen the presence of a hidden autoimmune phenomenon in non-allergic asthma.

  14. Sports in extreme conditions: the impact of exercise in cold temperatures on asthma and bronchial hyper-responsiveness in athletes.

    Science.gov (United States)

    Carlsen, Kai-Håkon

    2012-09-01

    Exercise-induced asthma (EIA) and bronchial hyper-responsiveness (BHR) are frequently reported among elite athletes of outdoor endurance winter sports, particularly in cross-country and biathlon skiers. The pathogenesis of EIA is related to water loss and heat-loss through the increased respiration during exercise, leading to mediator release, airways inflammation and increased parasympathetic nervous activity in the airways, causing bronchial constriction and BHR. In the competing elite athlete this is presently considered to be due to the frequently repeated increased ventilation during training and competitions in combination with the repeated environmental exposure to cold air in outdoor winter sports. It is important that athletes at risk of asthma and BHR are monitored through regular medical control with assessment of lung function and BHR, and when BHR or asthma is diagnosed, optimal controlling treatment through anti-inflammatory treatment by inhaled steroids should be started and relieving treatment (inhaled ipratropium bromide and inhaled β2-agonists) should be used to relieve bronchial constriction if present.

  15. Studies on bronchial hyperreactivity, allergic responsiveness, and asthma in rural and urban children of the highlands of Papua New Guinea.

    Science.gov (United States)

    Turner, K J; Dowse, G K; Stewart, G A; Alpers, M P

    1986-04-01

    The prevalence of asthma and allergic responsiveness in rural and urban children of the highlands of Papua New Guinea was studied. Bronchial provocation studies with histamine demonstrated significant bronchial hyperreactivity in 0.5% (1 in 195) rural and 1.7% (1 in 59) urban children, rates which were significantly lower than those observed in corresponding adult populations (7%). Urban children demonstrated a higher incidence of skin test reactivity toward Dermatophagoides pteronyssinus, Aspergillus fumigatus, and dog dander than did the rural children. However, there were no significant differences between these populations with regard to total serum IgE levels, the degree of parasitism as judged by stool examination, or allergic responses to Ascaris suum, plantain, and coffee bean husk. A more detailed study demonstrated age- and sex-related differences in total IgE and mite-specific RAST scores in the rural but not the urban population. These data suggest an active suppression of the capacity of children to mount an IgE response to environmental allergens such as the mite manifesting itself as low asthma prevalence. The data also indicate that, although the underlying defect of bronchial hyperreactivity in asthma may be genetically inherited, it is not revealed until the lung has received an allergen-induced inflammatory insult.

  16. Recognizing asthma mimics and asthma complications.

    Science.gov (United States)

    Amundson, Dennis; Seda, Gilbert; Daheshia, Massoud

    2011-10-01

    Asthma is a chronic inflammatory disorder of the airways characterized by airflow obstruction, bronchial hyperreactivity, and underlying inflammation. Two common reasons asthmatics fail standard therapy are incorrect diagnosis and failure to recognize underlying contributing factors. A correct diagnosis of asthma is of great importance to military practitioners since misdiagnosis or uncontrolled asthma affects an individual's operational readiness or determines whether one can receive a medical waiver to enlist in military service. This article presents four cases of patients with dyspnea that have conditions which mimic asthma or complicate asthma management: vocal cord dysfunction misdiagnosed as asthma, respiratory bronchiolitis interstitial lung disease mistaken as asthma, difficult-to-control asthma because of bronchiectasis and allergic bronchopulmonary aspergillosis, and difficult and fatal asthma. Asthma is contrasted to other respiratory disorders, and an outlined approach to asthma diagnosis and management is presented using the Global Initiative for Asthma guidelines.

  17. Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database

    Directory of Open Access Journals (Sweden)

    Lee H

    2016-04-01

    prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD.Methods: Patients with mild-to-moderate COPD (≥40 years were extracted from Korean National Health and Nutrition Examination Survey data (2007–2012 and were linked to the national health insurance reimbursement database to obtain medical service utilization records.Results: Of the 2,397 patients with mild-to-moderate COPD, 111 (4.6% had severe exacerbations over the 6 years (0.012/person-year. Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only COPD patients (P<0.001. A multiple logistic regression presented that asthma was an independent risk factor of severe exacerbations in patients with mild-to-moderate COPD regardless of adjustment for all possible confounding factors (adjusted odds ratio, 1.67; 95% confidence interval, 1.002–2.77, P=0.049. In addition, age, female, poor lung function, use of inhalers, and low EuroQoL five dimensions questionnaire index values were independently associated with severe exacerbation in patients with mild-to-moderate COPD.Conclusion: In this population-based study, the prevalence of severe exacerbations in patients with mild-to-moderate COPD was relatively low, compared with previous clinical interventional studies. Coexisting asthma significantly impacted the frequency of severe exacerbations in patients with mild-to-moderate COPD, suggesting application of an exacerbation preventive strategy in these patients. Keywords: bronchial asthma, chronic obstructive pulmonary disease, acute exacerbation

  18. Translational Study on the Relationships Between Body Mass Index, Levels of Serum Inlfammatory Factors and Bronchial Asthma in Children

    Institute of Scientific and Technical Information of China (English)

    FANG Ding-zhu

    2016-01-01

    Objective: To explore the relationships between body mass index (BMI), levels of serum inlfammatory factors and bronchial asthma in children. Methods:According to BMI, the enrolled 128 children with asthma in acute-outbreak period were assigned into obese group (n=29), skinny group (n=34) and control group (n=65). The children in three groups were all given routine treatment, including steroid aerosol, bronchodilators, lfuid infusion and correction of acidosis, and returned visit after 4 weeks. The asthma control condition, levels of serum inlfammatory factors, BMI and childhood asthma control test (C-ACT) scores were compared among three groups, and the relationships between C-ACT scores, BMI and levels of serum inlfammatory factors were analyzed. Results: Both completely and partially controlled rates were obviously lower in obese group and skinny group than in control group (P0.05). The levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were all higher in obese group than in skinny group and control group, and these indicators above in skinny group were higher than those in control group. The differences were statistically significant (P0.05). Conclusion: Both obesity and emaciation can lead to increased levels of serum inflammatory factors in children with asthma, which is adverse to asthma control. Maintenance of normal body weight can effectively decrease the levels of serum inflammatory factors and improve asthma control rate.

  19. Questionnaire-based characterization of bronchial asthma in the elderly: Analysis in Niigata Prefecture, Japan

    Directory of Open Access Journals (Sweden)

    Eiichi Suzuki

    2002-01-01

    Conclusions: Based on sufficient consideration of the problems specifically related to elderly asthmatic patients, adequate education and careful management of asthma in this group are required, and the accumulation of these steps will result in the achievement of the guidelines final goals.

  20. Undifferentiated bronchial fibroblasts derived from asthmatic patients display higher elastic modulus than their non-asthmatic counterparts.

    Directory of Open Access Journals (Sweden)

    Michal Sarna

    Full Text Available During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned 'ventral' stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-β-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.

  1. Undifferentiated bronchial fibroblasts derived from asthmatic patients display higher elastic modulus than their non-asthmatic counterparts.

    Science.gov (United States)

    Sarna, Michal; Wojcik, Katarzyna A; Hermanowicz, Pawel; Wnuk, Dawid; Burda, Kvetoslava; Sanak, Marek; Czyż, Jarosław; Michalik, Marta

    2015-01-01

    During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT) can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs) derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned 'ventral' stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-β-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.

  2. Measurement and clinical significance of IL-8 、IL-13 and IL-18 in serum of patients with bronchial asthma%支气管哮喘患者血清白细胞介素8、13、18水平的变化及意义

    Institute of Scientific and Technical Information of China (English)

    李富强

    2012-01-01

    Objective To investigate the change and significance of IL-8,IL-13 and IL-18 level in serum of patients with bronchial asthma.Methods 45 patients with acute exacerbation of bronchial asthma were selected (acute group),and remission group 45 patients and 30 healthy persons (control group) were selected.The serum IL-8,IL-13 and IL-18 levels were measured respectively by ELISA.Results The serum IL-8,IL-13 and IL-18 levels in acute group were significantly higher than that in control group and remission group ( t =5.21,5.13,4.99,5.32,5.48,5.59,P < 0.05 ) ; The serum IL-8,IL-13 and IL-18 levels in remission group were significantly higher than that in control group(t =4.18,4.71,4.89,P <0.05).Conclusion The levels of serum IL-8,IL-13 and IL-18 may be related to the severity of asthma attack.IL-8,IL-13 and IL-18 played important role in both pathogenesis and determination of asthma.%目的 探讨支气管哮喘患者血清白细胞介素8、13、18(IL-8、IL-13、IL-18)含量的变化及临床意义.方法 选择45例支气管哮喘急性发作期患者(急性发作期组)和45例缓解期患者(缓解期组),采用双抗体夹心ELISA法进行血清IL-8、IL-13和IL-18水平测定,另外选择30例健康体检者作为对照组,并进行统计学比较.结果 急性发作期组和缓解期组患者血清IL-8、IL-13和IL-18水平均明显高于对照组(t=5.21,5.13,4.99,5.32,5.48,5.59,均P<0.05);急性发作期组患者血清IL-8、IL-13和IL-18水平均明显高于缓解期组患者(t=4.18,4.71,4.89,均P<0.05).结论 IL-8、IL-13和IL-18可能参与了支气管哮喘的发病机制,支气管哮喘气道炎症可能与IL-8、IL-13和IL-18的上调有关.检测血清IL-8、IL-13和IL-18水平的变化对了解病情进展及指导用药具有十分重要的临床价值.

  3. Effects of Dexamethasone on the autophagy of peripheral blood T lymphocyte subpopulations in patients with acute episode of bronchial asthma%地塞米松对支气管哮喘急性发作患者外周血T淋巴细胞亚群自噬的影响

    Institute of Scientific and Technical Information of China (English)

    梁瑞韵; 伍卫; 黄瑾; 江山平

    2012-01-01

    Objective To explore the effects of Dexamethasone on the autophagy of peripheral blood T lymphocyte subpopulations in patients with acute episode of bronchial asthma. Methods T cell subsets ( CD4+ T, CD8+ T and CD4+ CD25+ T cells ) were isolated from peripheral blood in acute asthma and healthy people, and then were cultured with 10 -5 mol/L Dex. Morphological features of the autoph-agy were observed by electron microscopy ( TEM ) and fluorescent microscopy. After monodansylcadaverine ( MDC ) staining, the expres-sion of Foxp3 in CD4+ CD25+ T cells were quantitated by flow cytometry. Results First, the typical morphological autophagic features of T cells can be observed after cultivation with Dex. Second, autophagy could be up-regulated by Dex in CD4+ T and CD4+ CD25+ T cells in a-cute asthma ( P 0. 05 ). Conclusions The Autophagy increment in asthmatic peripheral T cell subsets induced by GCs may be one of the mechanism of GCs in asthma.%目的 本文拟研究地塞米松对哮喘急性发作患者外周血T淋巴细胞亚群自噬的影响.方法 分离哮喘组及健康者外周血T淋巴细胞亚群(CD+4 T,CD+8 T和 CD+4CD+25 T 细胞),分别与地塞米松(10-5 mol·L-1)共培养.首先以电子显微镜及荧光显微镜观察培养后细胞的自噬形态学改变;然后丹(磺)酰戊二胺(MDC)染色后,以流式细胞术检测上述细胞的自噬水平及CD+4CD+25 T细胞的Foxp3表达.结果 ①镜下可观察到与地塞米松共培养后细胞的典型自噬形态学改变;②地塞米松可以上调哮喘组外周血CD+4 T和 CD+4CD+25 T 细胞的自噬率(P0.05).结论 地塞米松诱导哮喘急性发作患者外周血T淋巴细胞亚群自噬水平的增高可能是糖皮质激素治疗哮喘的作用机制之一.

  4. Bronchial reactivity in hyperresponsive patients and healthy individuals: demonstration with high resolution computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Schueller, G. E-mail: gerd.schueller@univie.ac.at; Neumann, K.; Helbich, T.; Riemer, H.; Backfrieder, W.; Sertl, K.; Herold, C.J

    2004-11-01

    Objective: High resolution computed tomography (HRCT) was used to assess the extent of bronchial reactivity after inhalative bronchoprovocation and dilation in hyperresponsive patients and healthy subjects. Patients and methods: Patients with mild intermittent asthma, 15 with a >20% decrease in FEV{sub 1} and a >10 mmHg (PC{sub 20}+) in PaO{sub 2}, 12 with a <20% decrease in FEV{sub 1} and a >10 mmHg (PC{sub 20}-) in PaO{sub 2} after provocation, and eight healthy humans were included in the study. Changes in cross-sectional area in a total of 1256 bronchi and in bronchial wall area (792 bronchi) were evaluated after histamine-triggered bronchoprovocation and salbutamol-induced bronchodilation at high lung volumes (FVC 80%). Data were compared with the results of pulmonary function tests (FEV{sub 1}, PaO{sub 2}, PaCO{sub 2}). Results: In all groups, a significant decrease in bronchial cross-sectional area (P<0.001) and a significant increase in bronchial wall area (P<0.001) were observed subsequent to bronchoprovocation. After bronchodilation, the increase in cross-sectional area (P<0.001) and the further increase in airway wall area (P<0.01) were significant in all groups. In PC{sub 20}+ and PC{sub 20}- asthmatics, significant differences (P<0.05) in PaO{sub 2}, >10 mmHg between baseline and provocation were observed. In healthy persons, the PaO{sub 2} decrease was <10 mmHg (P>0.05). After histamine provocation, the decrease in FEV{sub 1} was measured in the PC{sub 20}+ group, whereas a <20% FEV{sub 1} decrease was found in the PC{sub 20}- and the control groups, respectively. No significant correlations were observed between radiological data and the results of pulmonary function tests. Conclusions: HRCT demonstrated bronchial reactivity in hyperresponsive patients and, unexpectedly, in healthy subjects. The applied pulmonary function tests failed to characterize bronchial reactions in the healthy subjects. Based on these results, HRCT is a useful tool by which

  5. CLINICAL OBSERVATION ON TREATMENT OF ALLERGIC BRONCHIAL ASTHMA WITH ACUPOINT APPLICATION THERAPY

    Institute of Scientific and Technical Information of China (English)

    陈劼; 赖新生

    2003-01-01

    In the present paper, the therapeutic effect of acupoint application of Chinese Materia Medica in thetreatment of allergic asthma was observed. The results revealed that topical application of drug-paste [mixture of pow-der of Mahuang (Herba Ephedrae), Xixin (Herba Asari), Baijiezi (Semen Sinapis Albae), etc. ] at the acupuncturepoints could improve symptoms and signs of allergic asthma patients, with the total effective rate being 69.57% ( 16/23) for the short-term effect, and 52.17% (12/23) for the long-term effect. In medication (Aminophylline) group, ofthe 25 cases of allergic asthma, 16 (64.0%) were effective after 4 weeks of treatment, while 6 (24.0%) were stilleffective that was shown by 6-months' follow up. The therapeutic effect of acupoint application group was significantlybetter than that of medication group in the long-term effect. Results also showed that no obvious interrelation betweenthe short-term therapeutic effect and the duration or the severity of the disease. Results also display that acupoint ap-plication therapy is an effective, safe and handy method with fewer side effects for asthma.

  6. Clinical characteristics of 41 patients with intractable asthma

    Directory of Open Access Journals (Sweden)

    Li BAI

    2011-09-01

    Full Text Available Objective To explore the clinical characteristics of intractable asthma,and to provide new knowledge for diagnosis and treatment of the disease.Methods Forty one patients with intractable asthma,admitted to the Institute of Respiratory Disease,Xinqiao Hospital of Third Military Medical University from Jan.2009 to Dec.2010,were included in present study.Spirometry tests were performed for all the 41 patients.Cell classification and counting were done in the induced sputum of 37 patients,and 34 patients underwent high-resolution chest computed tomography(HRCT.Results Incomplete reversibility of airflow obstruction(FEV1/FVC 0.03 of the total cells,13(35.1% and increased neutrophils( > 0.61 of total cells,6(16.2% showed increased both eosinophils and neutrophils,and only that of one patient showed normal percentage of the eosinophils and neutrophils.Chest HRCT of 34 patients showed thickening of bronchial wall in visible segment in 28 cases(82.3%,and in 22 cases(64.7% thickening of bronchial wall in secondary segments was accompanied with narrowed bronchus lumen,cylindrical bronchiectasis was predominant in 7 patients,and centrilobular emphysema was seen in 5 patients.Conclusion Airway remodeling,incomplete reversibility of airflow obstruction,airway inflammation appear to be the major clinical characteristics of intractable asthma.Combined use of chest HRCT,spirometry test,and cellular analysis of induced sputum may be helpful for identifying intractable asthma,and they provide the basis for individualized strategies to manage the disease.

  7. 小儿支气管哮喘的护理%Nursing Experience of Bronchial Asthma in Children

    Institute of Scientific and Technical Information of China (English)

    邹琳

    2014-01-01

    Objective To investigate the ef ect of nursing intervention on therapeutic ef ect in children with bronchial asthma and the ef ect of the implementation of health education. Methods In our hospital from 2008 July to 2009 June were treated 84 cases of bronchial, properly care;and 84 cases of children with asthma in children and their parents on the knowledge base of bronchial asthma, targeted to the guide. Results 98.81% children improvement of clinical manifestations, parents can bet er with treatment and prevention, reduce asthma at acks, to improve the quality of life. Conclusion The nursing and health education of good, can make the bronchial asthma children get bet er treatment, shorten the course of disease, accelerate rehabilitation.%目的探讨护理干预在支气管哮喘患儿和健康教育的实施效果的孩子对疗效的影响。方法在我们医院从2013年1月~2014年1月收治的84例支气管哮喘的治疗是合理的,适当的照顾;与孩子们和他们的父母哮喘支气管哮喘患儿84例的知识基础,有针对性的指导。结果98.81%患儿临床表现均有明显改善,肺部哮鸣音消失或减轻,咳嗽,胸闷,呼吸急促的显著降低;通过健康教育,儿童,家长可以有更好的治疗与预防,减少哮喘发作,改善生活质量。结论好的护理和健康教育,可使支气管哮喘儿童得到更好的治疗,缩短病程,加快康复。

  8. EFFECTS OF IL-4 UPON THE ACTIVITY OF STAT6 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    V. N. Mineev

    2009-01-01

    Full Text Available Abstract. The aim of the study is to specify the levels of STAT6, and phospho-STAT6 under the influence of IL-4 in patients with bronchial asthma (BA. The samples from ten healthy controls and thirty-three BA patients with allergic and non-allergic clinical forms of different severity were under investigation. Peripheral blood lymphocytes were treated with 10 ng/ml of IL-4 (Sigma Aldrich, USA for 1 h. Then the proteins (STAT6 and phospho-STAT6 expressed in peripheral lymphocytes were analyzed by Western blot of cell lysates. Preparation of the cell lysates and Western blotting were carried out using standard procedures. Antibodies against phospho-STAT6 and STAT6 (10 ng/ml were used (Cell Signaling, USA. Levels of thespecific proteins were standardized according to β-actin (Cell Signaling, USA. Treatment with IL-4 caused an increase of phospho-STAT6 levels in lymphocytes of all BA patients, as compared with control group. In allergic BA, the phospho-STAT6 levels were significantly higher than in non-allergic clinical forms. Expression of STAT6 in lymphocytes of patients with severe BA was significantly higher, as compared to BA of moderate severity. An IL-4-induced activation of the STAT6 transcription factor was revealed in an in vitro system, being mostly expressed in allergic BA. The level of STAT6 may serve as a BA severity index. This study was supported by a «Scholarship of the Year» grant from the St. Petersburg State Medical I. Pavlov University (2007.

  9. Sixty cases of bronchial asthma treated with electroacupuncture and cupping%电针配合拔罐治疗支气管哮喘60例

    Institute of Scientific and Technical Information of China (English)

    胡善家

    2011-01-01

    Bronchial asthma is a kind of common chronic intractable disease of repeated attacks.In recent years,the morbidity and mortality of asthma are increasing in the world.At present,about 150 to 200 million people suffer from this disease globally and about 180 000 people are died of asthma annually.Hence,the prevention and treatment of asthma have drawn the global attentions[1].From 2008 to 2010,the writer was under the mission of China's foreign medical aid in Vanuatus,one of the South Pacific Island Nations.Based on the theory of "the medical measurefor the prevention of disease" in Chinese medicine,acupuncture and cupping therapy were applied to treat 60 cases of bronchial asthma.The report is as follows.

  10. Bronchial asthma: correlation of quantitative CT and the pulmonary function test

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gun; Jin, Gong Yong; Jeon, Su Bin; Han, Young Min [Chonbuk National University Hospital, Research Institute of Clinical Medicine, Jeonju (Korea, Republic of)

    2007-02-15

    The purpose of this study was to assess the availability of quantitative computed tomography (QCT) in the evaluation asthma patients and to correlate its use with the pulmonary function test (PFT). Thirty asthmatic patients and thirty normal volunteers were prospectively evaluated by the use of HRCT and the PFT. By using 16 slice MDCT, HRCT was performed from the apex to the base of both lungs at the end inspiration and end expiration periods in all patients and images were reconstructed to a thickness of 1 mm (window level: -750 HU, window width: 1,500 HU). We analyzed each image for the whole lung using the Pulmo CT program. PFTs including FVC and FEV1 were performed one week prior and one week after the completion of a HRCT. The Difference of QCT (the mean lung density and subrange ratio) between volunteers and asthmatic patients was analyzed by using the Student's t-test. Spearman's correlation test was used to determine the association between PFT and QCT. The mean lung density (MLD) and subrange ratio were lower in asthmatic patients than in volunteers for and expiration and no difference was seen between asthmatic patients and volunteers for end inspiration. FVC and FEV1 were lower in asthmatic patients than in volunteers. A decrease in FVC and FEV1 correlated with changes in the MLD and subrange ratio for end expiration. QCT such as MLD and the subrange ratio using HRCT can be used to indirectly assess the pulmonary function of the asthma patient. The PFT seems to correlate better with the MLD and subrange ratio for expiratory QCT of the asthma patient than with inspiratory QCT.

  11. 儿童支气管哮喘反复性发作的相关危险因素分析%Analysis on associated risk factors of repeated episodes of child bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    谢伟洪

    2012-01-01

    目的 探讨儿童支气管哮喘反复性发作的相关危险因素,为流行病学研究提供依据,指导临床预防和控制.方法 随机选取在我院治疗的儿童哮喘患者88例为哮喘组,另取正常儿童88例为对照组,两组儿童性别、年龄差异无显著性.对两组儿童进行问卷调查,对结果进行统计学对比分析.结果 统计学研究显示,造成儿童支气管哮喘的危险因素包括居住环境、饮食习惯、呼吸道感染、家族遗传哮喘史、个人过敏史、家庭成员吸烟等.结论 为避免呼吸道感染、个人过敏史等危险因素使儿童支气管哮喘反复性发作,应加强对居住环境和饮食习惯的控制、提高父母文化教育程度、坚持母乳喂养和儿童补充鱼肝油,加强儿童支气管哮喘的预防和控制.%Objective To study the associated risk factors of repeated episodes of child bronchial asthma.and to provide basis for epidemiology research.guiding clinical prevention and control.Methods 88 patients with child bronchial asthma were randomly selected as the asthma group,another 88 normal children as control group.In two groups,children's gender and age had no significant difference.We used the questionnaire survey,and the results used statistical analysis.Results Statistics research showed that risk factors of child bronchial asthma included living environment,dietary habits,respiratory infection,family history of asthma,individual genetic history of allergies and family members smoking.Conclusions To avoid respiratory infection and the risk factors such as history of allergies to make child bronchial asthma repeated attacks,we should strengthen living environment and eating habits,improve parents' education degree,adhere to the breasffeeding and add cod-liver oil,in order to strengthen prevention and control for child bronchial asthma.

  12. Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II.

    Science.gov (United States)

    Nagel, G; Büchele, G; Weinmayr, G; Björkstén, B; Chen, Y-Z; Wang, H; Nystad, W; Saraclar, Y; Bråbäck, L; Batlles-Garrido, J; Garcia-Hernandez, G; Weiland, S K

    2009-05-01

    The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).

  13. Neutron, gamma and Roentgen fluorescent activation analysis of hair of children suffering from bronchial asthma

    Energy Technology Data Exchange (ETDEWEB)

    Alekseeva, O.A.; Belov, A.G.; Frontasyeva, M.V.; Gundorina, S.F.; Gustova, M.V.; Kusmenko, L.G.; Perelygin, V.P. E-mail: pergam@cv.jinr.ru; Zaverioukha, O.S

    2001-06-01

    The aim of present study was the multiparametric study of dangerous microelements content in the hair of children under school and primary school age which included 12 children ill with bronchial asthma and 11 control group persons in the town of Troitsk, Moscow Region. The hair specimens with weight 15-220 mg were analysed with the application of epithermal neutron activation analysis conducted at experimental installation REGATA and neutron source-unique Pulsed Fast Reactor IBR-2, with the application of combined gamma-neutron irradiation at Microtron MT-25 and with Roentgen Fluorescence Analysis device of JINR. The data of elements content in hair were obtained with solid state track detectors and semiconductor electronic spectrometers. The solid state track detectors provide the determination of U, Th, Bi and Be elements at the level of sensitivity up to 10{sup -8}-10{sup -9} g/g. These data were compared with more representative information about dangerous microelements concentration obtained with NAA and RFA analyses. The obtained concentrations of most elements vary in a wide range, but in agreement with the known data. The highest degree of element dispersion was observed for U, Th, Pb, I, Br, Sb, Co, K and Be (the radiation coefficient was higher than 100-200%). The presented analysis of results shows that in the clinical picture there is some proved correlation between an increased content of some element in hair and symptoms of their accumulation in the organism of ill children, the revelation of which is the basic idea of our examination.

  14. 白介素13在支气管哮喘发病中的作用%Effect of IL -13 on Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    王鹤翔; 刘建秋

    2014-01-01

    Through the study of the pathogenesis of bronchial asthma , the role of IL-13 on the pathogenesis of bronchial asthma was analyzed, especially the role of IL-13 on immune inflammation , airway remodeling and genetic inheritance was explored , to provide new implications for bronchial asthma.%通过对支气管哮喘发病机制研究总结,对白介素13( IL-13)在支气管哮喘发病机制中的作用进行分析,特别是IL-13在免疫-炎症、气道重塑、基因遗传方面的作用进行阐述分析。

  15. El componente educativo en el abordaje integral del asma bronquial The educational component in an integrated approach to bronchial asthma

    Directory of Open Access Journals (Sweden)

    María Paola Fasciglione

    2010-04-01

    Full Text Available El asma bronquial es una enfermedad inflamatoria crónica de las vías respiratorias cuya prevalencia está aumentando en el mundo. Actualmente no se dispone de un tratamiento curativo, y el objetivo principal de todo abordaje es el control de la enfermedad y la optimización de la calidad de vida de los pacientes. En este sentido, durante las últimas décadas se han estado implementando y evaluando programas de intervención complementarios a los tratamientos médicos convencionales. Gran parte de éstos consisten en intervenciones educativas o incluyen algún tipo de componente educativo. El objetivo del presente trabajo fue analizar las características y el impacto de las intervenciones educativas en el asma, a través de: a revisión actualizada sobre los diferentes tipos de intervenciones educativas desarrolladas e implementadas para el asma; b identificación de aspectos comunes a todas estas intervenciones; c análisis de los hallazgos de la investigación referidos a su impacto sobre la salud y la calidad de vida de los pacientes. Se concluye que las intervenciones educativas son efectivas para mejorar la salud y la calidad de vida de los pacientes con asma, y para reducir el uso y el costo de recursos sanitarios. Estos hallazgos señalan la importancia de incluir el componente educativo como parte esencial del abordaje integral de esta población clínica. Asimismo, la complejidad inherente al proceso educativo pone de manifiesto la necesidad del trabajo conjunto y complementario entre diferentes profesionales de la salud.Bronchial asthma is an inflammatory chronic disease of the respiratory tract whose prevalence is increasing worldwide. Since there is no curative treatment available, the principal objective of every approach is to control the disease and to improve the quality of life of patients. Over the last few decades, intervention programs supplementing conventional medical treatments have been tested and implemented. The

  16. Termoplastia brônquica: relato do primeiro tratamento endoscópico de asma na América Latina Bronchial thermoplasty: report on the first endoscopic treatment for asthma in Latin America

    Directory of Open Access Journals (Sweden)

    Adalberto Sperb Rubin

    2008-01-01

    Full Text Available A termoplastia brônquica é um novo procedimento broncoscópico que libera energia por radiofreqüência nas vias aéreas, com potencial redução da broncoconstrição causada pela contratura da musculatura lisa. Relatamos o caso de um homem de 48 anos, portador de asma persistente moderada, submetido à termoplastia brônquica. O tratamento aumentou o volume expiratório forçado no primeiro segundo, aumentou o número de dias livres de sintomas, reduziu o uso da medicação de resgate e melhorou o escore no questionário de Juniper Asthma Quality of Life Scale. A termoplastia brônquica foi bem tolerada e segura. Esta foi a primeira termoplastia brônquica na América Latina, com resultados estimulantes após 12 meses quanto ao seu potencial benefício em asmáticos pouco controlados.Bronchial thermoplasty is a new bronchoscopic procedure that delivers radiofrequency energy to the airway and potentially reduces the smooth muscle-mediated bronchoconstriction. We report the case of a 48-year-old man with persistent moderate asthma submitted to bronchial thermoplasty. The treatment increased the forced expiratory volume in one second, increased the number of symptom-free days, reduced the use of relief medications, and improved the Juniper Asthma Quality of Life Scale score. In this patient, bronchial thermoplasty was well tolerated and safe. This was the first bronchial thermoplasty performed in Latin America. At 12 months after the procedure, the results were encouraging in terms of its potential benefits in patients with difficult-to-control asthma.

  17. 吸入性糖皮质激素增加哮喘患者肺炎风险%Influence of inhaled corticosteroids on community-acquired pneumonia in patients with bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    周瑛; 常晶; 洪庆; 唐平; 周海; 肖平; 秦兴国

    2012-01-01

    目的 探讨哮喘患者长期吸入激素(ICS)是否增加肺炎发生风险.方法 选择上海市杨浦区市东医院07年1月~ 07年12月哮喘患者共300例,其中使用ICS者156例(A组),未使用者144例(B组),并选择同期健康志愿者150例(C组).结果 随访6、12、18、24个月结束时,A组患者ICS使用总量分别为28.50 g、50.10 g、61.30 g、69.10 g,发生肺炎分别为10、23、37、53例次;B组发生肺炎分别为7、14、22、29例次;C组发生肺炎分别为9、16、26、33例次.B组和C组比较差异无统计学意义(P>0.05).A组和B组、C组比较差异有统计学意义(P<0.05).结论 长期使用ICS增加肺炎风险,随着剂量和时间增加,肺炎发病机会增高,但预后良好.%Objective To determine wheather the use of ICS in asthma patients increased the risk of pneumonia. Methods 300 patients with asthma in Shidong hospitals from Jan. 2007 to Dec. 2007 were observed. There were 156 cases who used ICS in Group A, 144 cases without ICS in Group B, and 150 cases of normal control people as the Group C. In the 2 years following-up, the dosages of ICS and incidence of pneumonia were recorded. Results The dosages of ICS in Group A after 6 months, 12 months, 18 months,24 months were 28. 50 g,50. 10 g, 61. 30 g, and 69. 10 g, respectively. The occurrence times of pneumonia in Group A were 10 cases, 23 cases, 37 cases and 53 cases, respectively, while in Group B were 7 cases, Meases, 22 cases and 29 cases and in Group C were 9 cases, 16 cases, 26 cases and 33 cases. Compared between group B and C, there was no significant difference (P > 0. 05 ) . Compared between group A and B, and Group A and C, there were significant differences ( P < 0. 05 ) . Conclusion Long time use of ICS can increase the risk of pneumonia, and the incidence increases with the dosage and time of use of ICS, while the prognosis is well.

  18. Alveolar epithelial permeability in bronchial asthma in children; An evaluation by [sup 99m]Tc-DTPA inhalation scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Oishi, Takuji (Nippon Medical School, Tokyo (Japan))

    1993-02-01

    To evaluate alveolar epithelial permeability (k[sub ep]) in children with bronchial asthma, [sup 99m]Tc-DTPA (diethylene triamine penta acetate) aerosol lung inhalation scintigraphies were performed. There was no correlation between the k[sub ep] value and the severity of asthma. On the other hand, out of 10 cases which had no aerosol deposition defect in the lung field, 4 showed high k[sub ep] values on the whole lung field and 7 had high k[sub ep] value areas, particularly apparent in the upper lung field. These results suggest that even when the central airway lesions are mild, severe damage exists in the alveolar region of the peripheral airway. (author).

  19. Factors associated with patient visits to the emergency department for asthma therapy

    Directory of Open Access Journals (Sweden)

    AL-Jahdali Hamdan

    2012-12-01

    Full Text Available Abstract Background Acute asthma attacks remain a frequent cause of emergency department (ED visits and hospital admission. Many factors encourage patients to seek asthma treatment at the emergency department. These factors may be related to the patient himself or to a health system that hinders asthma control. The aim of this study was to identify the main factors that lead to the frequent admission of asthmatic patients to the ED. Methods A cross-sectional survey of all the patients who visited the emergency room with bronchial asthma attacks over a 9-month period was undertaken at two major academic hospitals. The following data were collected: demographic data, asthma control in the preceding month, where and by whom the patients were treated, whether the patient received education about asthma or its medication and the patients’ reasons for visiting the ED. Result Four hundred fifty (N = 450 patients were recruited, 39.1% of whom were males with a mean age of 42.3 ± 16.7. The mean duration of asthma was 155.90 ± 127.13 weeks. Approximately half of the patients did not receive any information about bronchial asthma as a disease, and 40.7% did not receive any education regarding how to use asthma medication. Asthma was not controlled or partially controlled in the majority (97.7% of the patients preceding the admission to ED. The majority of the patients visited the ED to receive a bronchodilator by nebuliser (86.7% and to obtain oxygen (75.1%. Moreover, 20.9% of the patients believed that the ED managed them faster than the clinic, and 21.1% claimed that their symptoms were severe enough that they could not wait for a clinic visit. No education about asthma and uncontrolled asthma are the major factors leading to frequent ED visits (three or more visits/year, p-value = 0.0145 and p-value = 0.0003, respectively. Asthma control also exhibited a significant relationship with inhaled corticosteroid ICS use (p-value =0

  20. 支气管哮喘控制程度与抑郁相关性研究%Bronchial asthma control degree with depression correlation research

    Institute of Scientific and Technical Information of China (English)

    杜淑珍; 常晓悦

    2011-01-01

    Objective The bronchial asthma (asthma) is a serious harm to the health of the human,and depression play an important role in asthma development and prognosis [1].This study discusses the correlation between asthma control degree and the depression.Methods We made a scale of ACQ and HAMD to test consistency in 50 cases for patients of asthma.And we did dada analysis in SPSS 13.0statistics software.Results ①There exists different degree of depression about 70% of the patients and the heavier asthma with the heavier depression.②After asthma treatment standardized for three months,depression degree and asthma control degree is still a linear positive correlation.Conclusions The asthma not only influence the quality of life serious,and can cause psychological barriers,such as depression,anxiety and fear.That treatment and management asthma standardized can reduce the incidence of depression and improve depression.At the same time,biological,social and psychological depends on each other,mutual penetration,affecting each other in asthma development process.They are form a complex network system,we only study with asthma development in the more broad background allround,multi-level,it will be possible to control asthma effective.%目的 支气管哮喘(简称哮喘)是一种严重危害人类健康的心身疾病,而伴发的抑郁在哮喘的发生、发展和预后中发挥着重要作用[1].本研究诣在探讨哮喘控制程度与抑郁之间存在的相关性.方法 对50例哮喘患者应用制定哮喘控制测试(ACQ)评分表及汉密尔顿抑郁量表(HAMD),作一致性测试.并进行SPSS 13.0统计学软件进行数据分析.结果 ①70%的患者存在不同程度抑郁,而且哮喘越重抑郁的程度越重.②哮喘规范治疗3个月后,抑郁程度与哮喘的控制程度仍呈线性正相关.结论 哮喘不但严重影响患者的生活质量,而且可以引起心理障碍,多表现为抑郁、焦虑和恐惧[2].规范治疗和管理哮喘

  1. Asma bronquial: factores de riesgo de las crisis y factores preventivos Bronchial asthma: risk factors of crises and preventive factors

    Directory of Open Access Journals (Sweden)

    Anselmo Abdo Rodríguez

    2007-09-01

    Full Text Available En los últimos años, y con motivo de los avances que se realizan en el campo de la investigación del asma bronquial, los conceptos en su prevención han ido cambiando entre los especialistas que lo tratan. Este trabajo tiene como objetivo llevar el conocimiento básico necesario a los profesionales de la medicina, para que a cada paciente asmático, atendido por primera vez, se le determinen los alergenos desencadenantes, los factores agravantes y socioculturales que le rodean y que pueden estar afectándolo. Se aborda la sensibilización a alergenos desde la etapa embrionaria y lactancia en el niño atópico, cuándo debemos considerar a un niño con alto riesgo alérgico, los factores de riesgo más importantes, con experiencias prácticas en el Hospital Universitario “Calixto García”, y las recomendaciones para la prevención de las enfermedades alérgicas en lactantes e infantes de alto riesgo alérgico.En recent years and advances in research field of bronchial asthma, features in its prevention has been changing among specialists treating it. Aim of this paper is to transmit the basic and necessary knowledge to medicine professionals for that in each asthmatic patient treated for the first time, the triggering allergens, aggravating factors, and the surrounded sociocultural ones, affecting him be determined. Authors approach sensitivity to allergens from embryonic stage and the lactation in atopic child, when we must to consider the case of an allergic and in high risk child, the more significant risk factors, with practical experiences in “Calixto García” University Hospital, and recommendations for preventions of allergic diseases in infants and breast-fed child in high risk of allergy.

  2. The therapeutic effect of psychotherapy in bronchial asthma%支气管哮喘心理治疗的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    李衡; 赵佩安; 龙飞华; 楚昊湘

    2012-01-01

    Objective To investigate the clinical effect of psychotherapy in bronchial asthma. Methods 252 patients with bronchial asthma adopted from January 2007 to January 2011 were randomly divided into control group( n = 110 ) and study group( n = 142 ), patients in control group were received medicine treatment, while patients in study group were added psychological treatment on basis of medicine treatment, after 1 month treatment, the therapeutic effect were observed and analysed. Results The study group decreased in score of anxiety and depression than that before treatment and contnol group( all the P < 0. 05 ), more effective in controlling the symptoms and signs of asthma, and more effective in improving lung function than the control group,the differences were statistical significant P <0. 05 ). The overall symptoms and signs control rate was 95. 8% , which was higher than control group( 80. 9% , P <0.05 ). The improvement of FVC, FEV, and PEF in study group were better than control group( P < 0. 05 ). Conclusion Psychological treatment assisted medicine teratment is an effective approach for patients with asthma.%目的 观察支气管哮喘心理治疗的临床疗效.方法 2007年1月-2011年1月收治的252例支气管哮喘患者随机分为对照组110例和研究组142例,对照组予药物治疗,研究组在药物治疗基础上进行心理治疗,治疗1个月后进行观察比较.结果 2组治疗后1个月较治疗前焦虑、抑郁评分值降低,且研究组低于对照组,差异有统计学意义(P均<0.05);哮喘症状、体征控制总有效率研究组为95.8%,高于对照组的80.9%(P<0.05);FVC、FEV1、PEF改善情况明显好于对照组(P<0.05).结论 心理治疗辅助药物治疗支气管哮喘患者是行之有效的治疗手段.

  3. 热休克蛋白与支气管哮喘%Heat shock proteins and bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    马礼兵; 向旭东

    2011-01-01

    Heat shock proteins are a series of widespread proteins due to heat stress from bacteria to human, which are broadly participate in the process of immune regulation. Bronchial asthma (asthma)is a chronic airway inflammatory disease, which is also considered an autoimmune disease. With asthmatic incidence increased year by year, it causes a global common concern and become a common disease that is seriously danger to public health. Nowadays, the cellular immune dysfunction is considered important to the pathogenesis of asthma. There is growing evidence that heat shock proteins are likely involved in the pathogenesis of asthma.%热休克蛋白是从细菌到人类均广泛存在的一类热应急蛋白质,并且广泛参与了机体的免疫调节过程.支气管哮喘(简称哮喘)是一种气道慢性炎症性疾病,亦被认为是一种自身免疫性疾病,其发病率逐年上升,已成为全球普遍关注、严重危害公众健康的常见病.目前,细胞免疫功能紊乱被视为哮喘的重要发病机制.越来越多的证据表明,热休克蛋白极可能参与哮喘的发病过程.

  4. Comparison of stayers, dropouts, and newcomers in a longitudinal population study of asthma and bronchial hyperresponsiveness: introduction of bias?

    Science.gov (United States)

    Ulrik, C S

    1995-01-01

    A random sample of children and adolescents from the general population in Copenhagen, Denmark, has been examined twice (6 years apart) with respect to asthma, allergy, and nonspecific bronchial hyperresponsiveness. To investigate potential bias resulting from loss of baseline subjects at follow-up (dropout bias) and bias resulting from subjects entering the study at the follow-up stage (newcomer bias), stayers (subjects who participated in both examinations) were compared to dropouts and newcomers, respectively. The sample consisted of 983 subjects (aged 7-17 years at the time of the baseline study), of whom 408 (199 boys) participated in both examinations (stayers), 119 (62 boys) in the baseline study only (dropouts), and 257 (124 boys in the follow-up study only (newcomers). Thus, a total of 784 subjects (80% of the sample) were examined either once or twice. At baseline dropouts did not differ from stayers with respect to anthropometric data, smoking habits, pulmonary function, or prevalence of positive skin prick tests, bronchial hyperresponsiveness, asthma, and allergic diseases. Likewise, these variables for newcomers were not different from those of the stayers apart from a significantly higher smoking rate in newcomers (45% vs. 32%, p = 0.003). Based on these findings and the high overall response rate, it seems reasonable to assume that the group of stayers is representative of the whole sample, apart from an underestimation of the number of smokers and, therefore, an underestimation of the risks associated with smoking.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Comparison of fractional exhaled nitric oxide levels in chronic obstructive pulmonary disease, bronchial asthma and healthy subjects of Nepal.

    Science.gov (United States)

    Shrestha, Sanjeet Krishna; Shrestha, Sanjeev; Sharma, Lucky; Pant, Subash; Neopane, Arpana

    2017-09-13

    Fractional exhaled nitric oxide levels in exhaled breath can indicate ongoing eosinophilic airway inflammation, specifically in asthma. But its utility is being explored for central airway inflammations, including chronic obstructive pulmonary disease. Normal levels of fractional exhaled nitric oxide (FENO50) have been defined in different studies but not in Nepal. This study compares FENO50 levels in normal subjects, asthma and chronic obstructive pulmonary disease. Single breath estimation of FENO50 was measured by a handheld electrochemical sensor-based device in normal non-smoking adults (n = 106), clinically controlled asthma (n = 106) and stable chronic obstructive pulmonary disease (n = 106). The geometric mean for FENO50 was 14 parts per billion (ppb) with a median of 16 ppb, first quartile at 11 ppb and third quartile at 20 ppb in normal non-smoking adults. The values were 31 ppb (geometric mean), 34 ppb (median), 17 ppb (first quartile) and 79 ppb (third quartile) in clinically controlled asthma. Similarly the values were 10 ppb (geometric mean), 11 ppb (median), 6 ppb (first quartile) and 17 ppb (third quartile) in stable chronic obstructive airway disease. The log-transformed data showed significantly higher FENO50 levels in the asthma group compared with the normal (p groups (p = 0.08). FENO50 levels were higher in bronchial asthma (despite disease control) than in normal non-smoking adults and subjects with stable chronic obstructive pulmonary disease. Levels of FENO50 were similar between the chronic obstructive airway disease and normal groups.

  6. Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot and Periodic (Cheyne-Stokes Breathings and Bronchial Asthma Attack

    Directory of Open Access Journals (Sweden)

    Andrey Golov

    2017-02-01

    Full Text Available An airflow in the first four generations of the tracheobronchial tree was simulated by the 1D model of incompressible fluid flow through the network of the elastic tubes coupled with 0D models of lumped alveolar components, which aggregates parts of the alveolar volume and smaller airways, extended with convective transport model throughout the lung and alveolar components which were combined with the model of oxygen and carbon dioxide transport between the alveolar volume and the averaged blood compartment during pathological respiratory conditions. The novel features of this work are 1D reconstruction of the tracheobronchial tree structure on the basis of 3D segmentation of the computed tomography (CT data; 1D−0D coupling of the models of 1D bronchial tube and 0D alveolar components; and the alveolar gas exchange model. The results of our simulations include mechanical ventilation, breathing patterns of severely ill patients with the cluster (Biot and periodic (Cheyne-Stokes respirations and bronchial asthma attack. The suitability of the proposed mathematical model was validated. Carbon dioxide elimination efficiency was analyzed in all these cases. In the future, these results might be integrated into research and practical studies aimed to design cyberbiological systems for remote real-time monitoring, classification, prediction of breathing patterns and alveolar gas exchange for patients with breathing problems.

  7. 孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎合并支气管哮喘患者血清C反应蛋白的影响%The influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by Montelukast sodium and Fluticasone nasal spray

    Institute of Scientific and Technical Information of China (English)

    郭良斌; 江永琴

    2016-01-01

    目的:研究孟鲁司特钠联和氟替卡松鼻喷雾剂治疗变应性鼻炎(AR)合并支气管哮喘患者血清C反应蛋白的影响。方法选取2010年2月~2015年2月我院接诊的100例AR合并支气管哮喘患者作为本次研究对象。按照随机数表法分为观察组和对照组,对照组给予孟鲁司特钠治疗,观察组给予孟鲁司特钠联和氟替卡松鼻喷雾剂治疗,观察两组患者治疗后血清c反应蛋白水平、临床症状和体征消失时间、治疗疗效情况。结果观察组C反应蛋白水平(5.03±1.02)mg/L小于对照组(18.92±3.02)mg/L,差异具有统计学意义(P<0.05);观察组喘憋消失时间、啰音消失时间、咳嗽消失时间、退热时间、住院时间(2.52±0.71、4.56±0.63、6.93±1.31、4.52±1.01、7.53±1.24)d均小于对照组(3.92±1.03、5.80±0.82、10.39±2.04、5.31±1.30、12.49±2.05)d,差异具有统计学意义(P<0.05);观察组总有效率98.00%(49/50)优于对照组80.00%(40/50),差异具有统计学意义(P<0.05)。结论孟鲁司特钠联和氟替卡松鼻喷雾剂治疗AR合并支气管哮喘疗效显著,能够降低c反应蛋白水平。%Objective To investigate the influence on serum C reactive protein in patients with allergic rhinitis and bronchial asthma treated by montelukast sodium and flutica-sone nasal spray. Methods 100 cases of allergic rhinitis with bronchial asthma were enrolled in this study from Febru-ary 2010 to February 2015. According to the random number table,patients were divided into observation group and control group. The control group was treated with montelukast sodi-um,while the observation group was treated with montelukast sodium and fluticasone nasal spray. Serum C reactive protein level,clinical symptoms,signs disappeared time and treat-ment efficacy were observed. Results C reactive protein level in the observation group(5.03±1.02)mg/L was less than that of the control

  8. Features of the Humoral Immune Response in School-age Children with Early-Onset Bronchial Asthma Depending on Acetylation Polymorphism

    Directory of Open Access Journals (Sweden)

    U.I. Marusyk

    2015-07-01

    Full Text Available The objective of the work was to study the individual indicators of the humoral immune system in school-age children with early-onset bronchial asthma (BA, considering acetylation phenotypes to improve treatment outcomes. There has been carried out a comprehensive examination of 34 school-age children with early-onset BA (disease first manifested at an early age. Depending on the course of the disease, patients were divided into two clinical groups. The first clinical group included 16 patients with slow acetylation (average content of acetylated sulfadimine in urine was less than 75.0 %. The second clinical group consisted of 18 pupils with fast acetylation (average level of acetylated sulfadimine in urine was over 75.0 %. All children underwent immunological blood test of II–III levels. The studies found that slow acetylation in patients with early-onset asthma increases the risk of reduction in the amount of interleukin-8 in blood serum < 5.3 pg/ml with odds ratio (OR 4.5 (95% confident interval (CI: 2.3–8.9, as well as the risk of higher concentration of IL-4 more than 4.0 pg/ml (OR = 1.9 that is associated with atopic inflammation of the body and allows you to personalize treatment tactics in these patients.

  9. Comportamiento del asma bronquial en adolescentes tratados en el Policlínico Universitario "Ana Betancourt" Course of bronchial asthma in adolescents seen in "Ana Betancourt" University Polyclinic

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    Tatiana de la Vega Pazitková

    2010-03-01

    consulting rooms of Basic Group No. 2 of "Ana Betancourt" University Polyclinic of Playa municipality during January, 2006 and January, 2007. As work tool we used the International Study of Asthma and Allergies in Childhood recognized at world scale. Results: the total figure of asthmatic persons raised to 52 adolescents with a discreet increment of male sex and of slight cases of this disease for a global prevalence of 64.1 %. There was of sub-registry of 20.9%. Conclusions: in patients from both consulting rooms there was a high prevalence of bronchial asthma in adolescents with a great affection in males. Patients show mainly the slight ways of this disease. There was a significant registry of bronchial asthma in the adolescents seen in "Ana Betancourt" University Polyclinic.

  10. 支气管哮喘的遗传多因素分析%Analysis of Genetic Factors of Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    刘源; 徐捷; 高福生; 刘长云

    2015-01-01

    [ ABSTRACT] Objective To investigate the genetic pattern and screen its relative risk factors of bronchial asthma,and to evaluate the relative importance of the major risk factors for the disease.Methods One hundred cases of bronchial asthma were selected from the out-patient and inpatient departments of pediatrics from the affiliated hospital of weifang medical university.Falconer regression method and Li-Mantel-Cart method were used to estimate the degree of inheritance and separation of bronchial asthma.The survey data were transformed into hierarchical grouping data in order to facilitate the information input,and all information was entered into the SPSS 21 data window for statisti-cal estimation.All the factors were tested by chi-square test,the factors affecting the incidence of asthma were selected,and the main risk fac-tors were screened out by Logistic regression analysis.Results The degree of inheritance of the first degree relatives of bronchial asthma was 84.05%,and the degree of inheritance of the two relatives was 68.84%,and the average weight of one or two degree relatives was 78.87%±6.99%.The separation ratio is less than 0.25.During our tests,we found that the incidence of asthma and these factors has statistical sig-nificance,including family asthma,allergies,eczema,and recurrent respiratory tract infections.Conclusion Bronchial asthma is a multi gene genetic disease,the separation ratio is 0.163.To avoid allergies,eczema,mycoplasma infection can prevent the occurrence of bronchial asth-ma.%目的:探讨支气管哮喘的遗传方式及筛选有关其危险因素,评估各主要危险因素对发病的相对重要性,为哮喘的三级预防提供理论依据。方法选取潍坊医学院附属医院儿科门诊及住院的100例支气管哮喘患儿。通过Falconer回归法和Li-Mantel-Cart法估计支气管哮喘的遗传度和分离比。将调查资料转化为等级分组资料以便于信息录入,将以上信息输入SPSS 21数

  11. Serum resistin as an asthma marker and predictor of inhaled corticosteroid response in bronchial asthma in children

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    Hassan M. Al-Asy

    2017-07-01

    Conclusions: From these results we can conclude that resistin can be considered as a marker of asthma and its severity and high resistin levels can predict favourable anti-inflammatory effect of inhaled glucocorticoids suggesting that resistin may be a marker of steroid-sensitive genotype in asthma in children.

  12. Lithium Attenuates TGF-β1-Induced Fibroblasts to Myofibroblasts Transition in Bronchial Fibroblasts Derived from Asthmatic Patients

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    Marta Michalik

    2012-01-01

    Full Text Available Bronchial asthma is a chronic disorder accompanied by phenotypic transitions of bronchial epithelial cells, smooth muscle cells, and fibroblasts. Human bronchial fibroblasts (HBFs derived from patients with diagnosed asthma display predestination towards TGF-β-induced phenotypic switches. Since the interference between TGF-β and GSK-3β signaling contributes to pathophysiology of chronic lung diseases, we investigated the effect of lithium, a nonspecific GSK-3β inhibitor, on TGF-β1-induced fibroblast to myofibroblast transition (FMT in HBF and found that the inhibition of GSK-3β attenuates TGF-β1-induced FMT in HBF populations derived from asthmatic but not healthy donors. Cytoplasmically sequestrated β-catenin, abundant in TGF-β1/LiCl-stimulated asthmatic HBFs, most likely interacts with and inhibits the nuclear accumulation and signal transduction of Smad proteins. These data indicate that the specific cellular context determines FMT-related responses of HBFs to factors interfering with the TGF-β signaling pathway. They may also provide a mechanistic explanation for epidemiological data revealing coincidental remission of asthmatic syndromes and their recurrence upon the discontinuation of lithium therapy in certain psychiatric diseases.

  13. Study of pulmonary and autonomic functions of asthma patients after yoga training.

    Science.gov (United States)

    Khanam, A A; Sachdeva, U; Guleria, R; Deepak, K K

    1996-10-01

    "The concept of yoga is helpful for the treatment of Bronchial Asthma", has created a great interest in the medical research field. In order to investigate whether autonomic functions and pulmonary functions are improved in asthma patients after short term yoga training, a study was conducted with nine diagnosed bronchial asthma patients. Yoga training was given for seven days in a camp in Adhyatma Sadhna Kendra, New Delhi. The autonomic function tests to measure the parasympathetic reactivity (Deep Breathing test, Valsalva Manouever), Sympathetic reactivity (Hand Grip test, Cold Pressure test), and pulmonary function tests FVC, FEV1, PEFR, PIF, BHT and CE were recorded before and after yoga training. The resting heart rate after yoga training (P yoga training as indicated by significant (P < 0.01) reduction in DBP after HGT. There was no change in parasympathetic reactivity. The FVC, FEV1, PEFR did not show any significant change. The PIF (P < 0.01), BHT (P < 0.01) and CE (P < 0.01) showed significant improvement. The results closely indicated the reduction in sympathetic reactivity and improvement in the pulmonary ventilation by way of relaxation of voluntary inspiratory and expiratory muscles. The "comprehensive yogic life style change programme for patients of Bronchial Asthma" have shown significant benefit even within a short period.

  14. Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial

    NARCIS (Netherlands)

    Castro, Mario; Rubin, Adalberto S.; Laviolette, Michel; Fiterman, Jussara; Lima, Marina De Andrade; Shah, Pallav L.; Fiss, Elie; Olivenstein, Ronald; Thomson, Neil C.; Niven, Robert M.; Pavord, Ian D.; Simoff, Michael; Duhamel, David R.; McEvoy, Charlene; Barbers, Richard; ten Hacken, Nicolaas H. T.; Wechsler, Michael E.; Holmes, Mark; Phillips, Martin J.; Erzurum, Serpil; Lunn, William; Israel, Elliot; Jariour, Nizar; Kraft, Monica; Shargill, Narinder S.; Quiring, John; Berry, Scott M.; Cox, Gerard

    2010-01-01

    Rationale Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle. Objectives: To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic desp

  15. Dysfunctional interaction of C/EBPα and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells

    NARCIS (Netherlands)

    Roth, Michael; Johnson, Peter R.A.; Borger, Peter; Bihl, Michel P.; Rüdiger, Jochen J.; King, Gregory G.; Ge, Qi; Hostettler, Katrin; Burgess, Janette K.; Black, Judith L.; Tamm, Michael

    2004-01-01

    BACKGROUND: Increased proliferation of bronchial smooth-muscle cells may lead to increased muscle mass in the airways of patients with asthma. The antiproliferative effect of glucocorticoids in bronchial smooth-muscle cells in subjects without asthma is mediated by a complex of the glucocorticoid re

  16. Survey among doctors related with bronchial asthma patients in central hospitals of region level cities in Shaanxi province%陕西省地区级城市中心医院支气管哮喘相关科室医师的调查分析

    Institute of Scientific and Technical Information of China (English)

    宋立强; 吴昌归; 呼彩莲; 李海东; 李文革; 何小鹏; 张和平

    2008-01-01

    表示为每位接诊的哮喘患者制定了长期用药方案及随访计划.结论 通过调查了解了陕西省地区级城市中心医院医师对哮喘知识的掌握程度.总体来看,呼吸内科医师的掌握程度高于其他专科,但距离普及规范化治疗理念还任重而道远.这些资料将为联盟在西部地区的医师教育工作提供参考.%Objective To evaluate the situation of grasping bronchial asthma(asthma) knowledge ofdoctors related with asthma patients in central hospitals of region level cities in Shaanxi province, and toappraise the effect of doctor education in order to provide evidence for the next step of education. MethodsSix hospitals were selected from six region level cities, where questionnaire survey was completed in thedorctors from the department of respiratory medicine, internal medicine, emergency or pediatrics. Thequestionnaire involved pathogenesy, prevention, treatment and advencement of global initiative for asthma(GINA). Results 187 doctors completed the qusetionnaire,and the ratio of every speciality was 29.9%,23.0%,26.7% and 20.3%, respectively. 58.9%-62.5% dorctors in respiratory knew the organization ofasthma clearly and the ratio was very higher than that in other spciality. But 10.7% dorctors did not knowthe significance of GINA. World Asthma Day was known in 87.6%. 69.9% doctors understood thepathogenesy of slow airway inflammation, while the highest ratio was 78.6% in repiralogy and the lowestone was 55.8% in internal medcine. Repiratory doctor knew the classification of asthma according tocontroled level most clearly in all people. 54.8%-75.0% doctors knew the importance of inhaledcorticosteroid (ICS)in therapy. But the effect of asthma control test and stort-acting β2-agonist wasunderstood only by 7.1% and 42.9% respiratory doctors. 37.8% doctors knew the use of long-actingβ2-agonist should be combined with ICS. 52.0%-76.4% doctors knew the blocker of leukotriene receptorwas control medcine. 51

  17. The clinical effect observation of phentolamine in severe bronchial asthma%酚妥拉明辅治重症支气管哮喘疗效观察

    Institute of Scientific and Technical Information of China (English)

    穆凤鸣

    2015-01-01

    目的:观察酚妥拉明辅治重症支气管哮喘的疗效。方法将52例重症支气管哮喘患者随机分为治疗组和对照组各26例。对照组给予维持水电解质平衡、纠正脱水、硫酸沙丁胺醇、氢化可的松、氨茶碱、硫酸镁治疗。治疗组在对照组基础上加用酚妥拉明治疗。比较2组临床疗效。结果治疗组总有效率为96.2%高于对照组的80.8%(P<0.05)。结论在基层医院应用酚妥拉明辅治支气管哮喘,安全有效、值得推广应用。%ObjectiveToanalysistheclinicaleffectofphentolamineinseverebronchialasthma.Methods 52cases patients with severe bronchial asthma were randomly divided into treatment group and control group ,each of 26 cases.Control group was treated by water and electrolyte balance ,correcting dehydration ,albuterol sulfate ,hydrocortisone ,aminophylline ,mag-nesium sulfate.Treatment group was treated ,on the basis of control group ,was treated by phentolamine .After treatment,com-pared the clinical effect and adverse reactions .Results The total efficiency of treatment (96.2%)was higher than that of con-trol(80.8%),the difference was statistically significant (P<0.05).Conclusion Phentolamine in severe bronchial asthma has an good effect ,and safe ,worthy of clinical application .

  18. Applied value of dead spaces measuring in bronchial asthma%死腔测定在支气管哮喘中应用价值的研究

    Institute of Scientific and Technical Information of China (English)

    齐广生; 刘锦铭; 高蓓兰; 储海青; 杨文兰; 郑卫

    2009-01-01

    Objective To investigate the applied value and implications of dead spaces from volumetric capnography(VCap)in bronchial asthma(asthma).Methods The ventilation and volume function together with series dead spaces,which include Langley dead space(VDL),Fowler dead space(VDF)and Wolff dead space(VDW) were measured in 52 patients with asthma exacerbation and 35 controls.Results Compared with healthy group,VDL,VDF and VDW in asthma group showed significant decrease(P<0.01,0.01,0.01).In asthma group,VDL,VDF and VDW were all negative correlated with FEVl%pred,FEV1/FVC%,PEF%pred,FEF25%pred,FEF50%pred,FEF75%pred and MMEF%pred(P<0.05).At the same time,they were positive correlated with RV.TLC and RV/TLC(P<0.05).Conclusions The dead spaces measurement of VCap is easy to be cooperated by patients.And it may have clinical value in diagnosing asthma.%目的 探讨容积二氧化碳图(volumetric capnography,VCap)技术死腔测定在支气管哮喘(简称哮喘)中的应用价值及临床意义.方法 对52例急性发作期哮喘患者及35名健康志愿者的常规肺功能指标及Langley死腔(VDL)、Fowler死腔(VDF)、Wolff死腔(VDW)进行测定分析.结果 本研究显示:哮喘组中VDL、VDF及VDW均较对照组显著减小(P<0.01,0.01,0.01).相关分析显示:VDL、VDF和VDW分别与FEV1占预计值%、FEV1/FVC%、PEF占预计值%、FEF25占预计值%、FEF50占预计值%、FEF75占预计值%、MMEF占预计值%呈负相关(P<0.05),与RV占预计值%、TLC占预计值%、Rv/TLC%呈正相关(P<0.05).结论 VCap死腔测定患者易于配合,对哮喘的辅助诊断及进一步了解其病理生理改变具有一定的临床价值和意义.

  19. Analysis of the treatment of bronchial asthma complicated with pneumonia%老年支气管哮喘合并肺炎的诊治分析

    Institute of Scientific and Technical Information of China (English)

    蒙建凤; 李超乾

    2014-01-01

    Objective To study of clinical diagnosis and treatment of elderly bronchial asthma patients with pneumonia .Methods One hundred and twelve elderly patients with bronchial asthma complicated with pulmonary in -fection were treated for asthma .Sputum culture were performed to find fungal infections .The type of pathogenic bac-teria were determined to correctly choose antibiotics .Results In 112 patients, most had infections due to gram posi-tive bacteria, including spore bacillus , Lester bacteria, Corynebacterium and erysipelothrix .The patients were treated with preferred penicillin combined with aminoglycosides as an anti-inflammatory therapy , the period of treatment was 2~3 weeks.For penicillin hypersensitive patients , tetracycline and chloramphenicol were available .After treatment, 71 cases were cured , 37 cases improved , 4 cases were healed , the healing rate was 96.43%.Conclusion The eld-erly patients with bronchial asthma complicated with pneumonia have the history of long time use of corticosteroids , antibiotics and other drugs , coupled with reduced immune function or wasting disease , so in the treatment for these patients diseases the drug intake of treating other should be limieted .%目的:探讨老年支气管哮喘合并肺炎的临床诊治。方法选择112例老年支气管哮喘合并肺炎的患者,在针对哮喘进行治疗的同时,行痰培养,确定有无真菌感染和病原菌的类型,正确选择抗菌药物。结果112例患者中,86例为革兰阳性菌感染,包括芽胞杆菌属、李斯特菌属、棒状杆菌属和丹毒丝菌属。治疗首选青霉素,并加氨基糖甙类联合抗炎,疗程2~3周。青霉素过敏者可用四环素和氯霉素。经过治疗71例治愈,37例好转,4例未愈,治愈好转率为96.43%。结论老年支气管哮喘合并肺炎患者多伴有免疫功能降低及消耗性疾病,长时间应用糖皮质激素、抗生素等药物时,应限制治疗其它疾病药物的摄入量。

  20. Knowledge and Attitudes of GPs in Saxony-Anhalt concerning the Psychological Aspects of Bronchial Asthma: A Questionnaire Study

    Directory of Open Access Journals (Sweden)

    Werwick Katrin

    2010-12-01

    Full Text Available Abstract Bronchial Asthma is a worldwide condition with particularly high prevalence in first world countries. The reasons are multifactorial but a neglected area is the psychological domain. It is well known that heavy emotions can trigger attacks and that depression negatively affects treatment outcomes. It is also known that personality type has a greater effect on disease prevalence than in many other conditions. However, many potential psychological treatments are hardly considered, neither in treatment guidelines nor in reviews by asthma specialists. Moreover, there is very little research concerning the beliefs and practices of doctors regarding psychological treatments. Using a questionnaire survey we ascertained that local GPs in Saxony-Anhalt have reasonably good knowledge about the psychological elements of asthma; a third consider it to be some of the influence (20-40% aetiology and a further third consider it to be even more important than that (at least 40% total aetiology. Our GPs use psychosomatic counseling sometimes or usually in the areas of sport and smoking (circa 85% GPs, although less so regarding breathing techniques and relaxation (c40% usually or sometimes do this However despite this knowledge they refer to the relevant clinicians very rarely (98% sometimes, usually or always refer to a respiratory physician compared with only 11% referring for psychological help.

  1. Social networks: a new source of psychological stress or a way to enhance self-esteem? Negative and positive implications in bronchial asthma.

    Science.gov (United States)

    D'Amato, G; Cecchi, L; Liccardi, G; Pellegrino, F; D'Amato, M; Sofia, M

    2012-01-01

    The Internet and, in particular, social networks are an increasingly important part of daily life for both adolescents and adults who maintain a virtual relationship with others sharing interests and goals. Very often, they disclose more about themselves online than they do in person. However, cyberbullying and cyberostracism can be problematic for adolescents and sensitive individuals, who might be negatively affected by social networks. Some studies have shown an increased risk of depression, whereas others suggest beneficial effects through enhanced communication, social connection, and self-esteem. Bronchial asthma is an increasingly frequent disease in the industrialized world, and psychological implications play a role in increasing or in reducing its severity. One year after the case report of an asthma exacerbation that may have been triggered by Facebook, it seems reasonable to analyze the effects of social networks on bronchial asthma.

  2. Discussion on Related Factors in Children of Bronchial Asthma%小儿支气管哮喘相关影响因素探讨

    Institute of Scientific and Technical Information of China (English)

    吴文红

    2011-01-01

    目的:探讨小儿支气管哮喘的相关影响因素.方法:分析我院就诊的102例支气管哮喘儿童临床资料,并采用问卷调查方式,结合文献回顾分析.结果:特异性体质是哮喘发作的先决条件,哮喘诱发因素中感染(83.33%)、冷空气吸入(62.75%)占较大比例.其他诱因:剧烈运动(2.94%)、精神(4.90%)、食用海鲜(4.90%)等也应引起注意.结论:呼吸道感染是诱发哮喘发作的重要因素.为减少哮喘发作,应尽可能地减少过敏源接触,同时还应积极预防上呼吸道感染.%Objective: To investigate related influence factors of pediatric asthma.Methods:Clinical data of 102 children patients with bronchial asthma in our hospital were analyzed,questionnaires were adopted to combine with analysis of literature review.Results: The specific constitution was a prerequisite for asthma attack,and infection(83.33%)and cold air inhalation (62.75%)in asthma triggering factors occupy greater proportion. Other incentives such as vigorous exercise(2.94%),mental (4.90%),seafood(4.90%)and the like also should cause concern. Conclusion;The respiratory tract infection was an important factorin inducing asthma.In order to reduce asthma attacks,exposure to allergens should be reduced as far as possible,and upper respiratory tract infection also should be actively prevented at the same time.

  3. Translational Study on the Relationships Between Body Mass Index, Levels of Serum Inflammatory Factors and Bronchial Asthma in Children

    Directory of Open Access Journals (Sweden)

    Ding-zhu FANG

    2016-09-01

    Full Text Available Objective: To explore the relationships between body mass index (BMI, levels of serum inflammatory factors and bronchial asthma in children.Methods: According to BMI, the enrolled 128 children with asthma in acute-outbreak period were assigned into obese group (n=29, skinny group (n=34 and control group (n=65. The children in three groups were all given routine treatment, including steroid aerosol, bronchodilators, fluid infusion and correction of acidosis, and returned visit after 4 weeks. The asthma control condition, levels of serum inflammatory factors, BMI and childhood asthma control test (C-ACT scores were compared among three groups, and the relationships between C-ACT scores, BMI and levels of serum inflammatory factors were analyzed.Results: Both completely and partially controlled rates were obviously lower in obese group and skinny group than in control group (P<0.05, but there was no statistical significance between obese group and skinny group (P>0.05. The levels of serum high-sensitivity C-reactive protein (hs-CRP, interleukin-6 (IL-6 and tumor necrosis factor-α (TNF-α were all higher in obese group than in skinny group and control group, and these indicators above in skinny group were higher than those in control group. The differences were statistically significant (P<0.05 or P<0.01. C-ACT scores increased in sequence among obese group, skinny group and control group, and the differences were statistically significant between two any groups (P<0.01. Correlation analysis revealed that C-ACT scores had a significantly negative correlation with levels of hs-CRP, IL-6 and TNF-α (r=-0.856, P=0.000; r=-0.616, P=0.000; r=-0.296, P=0.001. BMI was not correlated with C-ACT scores and levels of hs-CRP, IL-6 and TNF-α (P>0.05.Conclusion: Both obesity and emaciation can lead to increased levels of serum inflammatory factors in children with asthma, which is adverse to asthma control. Maintenance of normal body weight can effectively

  4. Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease.

    Science.gov (United States)

    Freidin, Maxim B; Kobyakova, Olga S; Ogorodova, Ludmila M; Puzyrev, Valery P

    2003-01-01

    Two polymorphisms in the IL4 (G/C 3'-UTR) and IL5 (C-703T) genes were studied in a sample of families whose probands had atopic bronchial asthma (BA) (66 families, n = 183) and in a group of non-cognate individuals with the severe form of the disease (n = 34). The samples were collected from the Russian population in the city of Tomsk (Russia). Using the transmission/disequilibrium test (TDT), a significant association of allele C-703 IL5 with BA was established (TDT = 4.923, p = 0.007 +/- 0.0007). The analysis of 40 individuals with mild asthma and 49 patients with the severe form of the disease revealed a negative association of genotype GG IL4 (OR = 0.39, 95% CI = 0.15-0.99, p = 0.035), and also a trend towards a positive association of the GC IL4 genotype (OR = 2.52, 95% CI = 0.98-6.57, p = 0.052) with mild BA. There was a concordance of the clinical classification of BA severity with the 'genotype' (McNemar's chi(2) test with continuity correction constituted 0.03, d.f. = 1, p = 0.859). These results suggest that polymorphisms in the IL4 and IL5 genes contribute to the susceptibility to atopic BA and could determine the clinical course of the disease.

  5. Analysis of risk factors of childhood bronchial asthma%儿童支气管哮喘发病的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    彭桂英

    2014-01-01

    Objective To investigate and analyze the risk factors of childhood bronchial asthma. Methods 176 children with bronchial asthma treated in our hospital were selected as the asthma group and 176 normal children in the corresponding period were selected as the normal group in the same time. First, SPSS17.0 was used to conduct univariate analysis on 17 pathogenic factors of childhood bronchial asthma and the screened out single factors with P < 0.05 served as the independent variables of Logistic regression model for multivariate analysis. Then the high risk factors of childhood bronchial asthma were obtained. Results Univariate analysis showed that there were 10 single factors influencing childhood bronchial asthma, with statistically significant differences to the normal group (P<0.05). Logistic multivariate regression analysis showed that the high risk factors of childhood bronchial asthma were respiratory tract infection, family history of asthma,non-supplement of cod liver oil and family smoking and the protective factor of asthma was breastfeeding. Conclusion Preventing high risk factors of childhood bronchial asthma actively and increasing protective awareness are of important significance to the prevention and control of childhood bronchial asthma.%目的:探讨儿童支气管哮喘发病的危险因素。方法选取就诊于我院的儿童支气管患儿176例纳入哮喘组,同时选取同期正常儿童176例纳入正常组。首先采用SPSS17.0作单因素分析可能引起儿童支气管哮喘的发病因素17项,筛选出P<0.05的单因素作Logistic回归模型的自变量,作多因素分析,得出影响儿童支气管哮喘的高危因素。结果经单因素分析结果显示,影响儿童支气管哮喘的单因素共有10项,且P<0.05,与正常组对比具有统计学意义。Logistic多因素回归分析结果显示,影响儿童支气管哮喘的高危因素为呼吸道感染、家族哮喘史、未补充鱼肝油、家人

  6. Greenhoese and farmers bronchial asthma%温室大棚与农民支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    刘婷; 滕琳; 吴立平

    2010-01-01

    目前从事温室大棚种植的农民支气管哮喘的发病率在逐年增多,这与大棚内的特殊环境(高温、高湿、空气流通不畅、霉菌、螨虫等)、棚内作物种植种类(西红柿、香菇、花卉等)及喷洒农药时防护不当等因素密切相关.%At present,the farmers involved in greenhouse incidence of bronchial asthma increasing year by year,which is shed within a specific environment(high temperature,high humidity,poor air circulation,mold,mite,etc.),shed crop species(tomatoes,mushrooms,flowers,etc.)and spray of pesticides is closely related to protective factors such as improper.

  7. Oxidative stress and anti-oxidant therapy in bronchial asthma%氧化应激及抗氧化治疗与支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    包爱华; 周新

    2012-01-01

    支气管哮喘(简称哮喘)是一种常见的慢性气道炎症性疾病,氧化应激在其发生发展机制中具有重要的作用.机体受到的氧化应激刺激有内源性和外源性两种途径,通过产生的氧自由基对细胞和分子造成多种形式的损伤.哮喘患者体内氧化水平升高,抗氧化机制降低.研究发现,在哮喘患者或动物模型体内使用一些具有抗氧化作用的物质进行干预可有效预防或拮抗氧化应激损伤,对于哮喘的防治具有重要的意义.%Bronchial asthma is a common chronic airway inflammatic disease. Oxidative stress plays an important role in the pathogenesis and development of asthma.The stimuli of oxidative stress can be originated endogenously or exogenously,both produce various injuries on molecules and cells through the induction of radical oxygen species.The level of oxidative stress is often elevated in asthmatic patients,accompanied by the impaired anti-oxidant capacity. Numerous studies using anti-oxidant therapies or interventions on both human patients and animal models have elicited some positive results.It is of great importance in prophylaxis and treatment of asthma to efficiently prevent or attenuate oxidative stress-induced damage.

  8. Characteristics of Atopic Bronchial Asthma in Seniors over 80 Years of Age

    Directory of Open Access Journals (Sweden)

    Andrzej Bożek

    2013-01-01

    Full Text Available Background. Asthma in the elderly is an important public health problem. The aim of this study was to assess the prevalence and characteristics of asthma in seniors. Materials and Methods. The study involved 105 people of at least 80 years of age (mean age of 84.1 ± 3.9 years selected from a group of 1860 individuals. Spirometry, the methacholine test, allergy diagnosis, a measurement of exhaled nitric oxide, and administration of the asthma quality of life questionnaire (AQLQ were performed. Results. The average morbidity of asthma in the study population of elderly people (at least 80 years of age was 5.6% (105 people of the confidence interval (95% CI: 5.1–6.0. In the study group, 34% of the elderly asthmatics had uncontrolled asthma, 47% had partly controlled asthma, and only 24% had fully controlled asthma. Allergy to house dust mites was predominant. The average total score on the AQLQ was 4.12 ± 0.72 (arithmetic mean ± standard deviation for the seniors, which was significantly lower than the score for the young. Conclusion. The pathogenesis, natural history, and value of the basic diagnostic methods of asthma in the elderly are similar to those observed in younger age groups.

  9. Genome screen for asthma and bronchial hyperresponsiveness : Interactions with passive smoke exposure

    NARCIS (Netherlands)

    Meyers, DA; Postma, DS; Stine, OC; Koppelman, GH; Ampleford, EJ; Jongepier, H; Howard, TD; Bleecker, ER

    2005-01-01

    Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma. Objective: We s

  10. Combination therapy versus monotherapy for gastroesophageal reflux in children with difficult-to-treat bronchial asthma

    Directory of Open Access Journals (Sweden)

    Adel Salah Bediwy

    2014-01-01

    Conclusions: Combination of domperidone and esomeprazole was more effective in improving the endoscopic reflux score, childhood-asthma control test (C-ACT and FEV1 (% of predicted and significantly reduced the sputum SP than the use of esomeprazole only in children with difficult-to-treat asthma.

  11. Lung Aquaporins and bronchial asthma%肺水通道蛋白与支气管哮喘

    Institute of Scientific and Technical Information of China (English)

    张君; 骆仙芳; 王会仍

    2012-01-01

    通过对肺水通道蛋白(aquaporins,AQPs)的结构、分布及功能的研究,发现AQPs与支气管哮喘(简称哮喘)之间存在密切关系,其中,AQP1参与了肺部水的转运、哮喘急性炎症期的发病机制,AQP3可能在保持气道表面的液体平衡及防止细菌入侵、气道重塑等方面起着重要的作用,AQP4可能参与了哮喘条件下黏液分泌的调控,AQP5则与气道高反应性、气流受限、调节气道水稳态有关,这些为哮喘的诊断及治疗开辟了新的思路.%By the researches of Lung Aquaporins' structure,distribution and function,it is discovered that Lung Aquaporins are closely associated with bronchial asthma,among of them,AQP1 participates in the transportation of the lung water and the pathogenesis of asthma' acute inflammatory period; AQP3 may play an important part in keeping the water balance of the air passage’ surface,and preventing the invading of bacteria,remodeling of air passage; AQP4 may participates in the regulation of mucus secreting under asthma; AQP5 is connected with airway hyperreactivity,airflow limitation,and airway water balance regulation,all of these open up new ideas of asthma' diagnosis and treatment.

  12. 心理干预对治疗支气管哮喘的影响%Effects of Psychological Interventions on Treatment of Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    朱以芳; 刘悦; 赵芳; 王艳; 贺江妮; 赵娟; 李小飞

    2011-01-01

    Objective To explore the psychosocial factor and effective psychological interventions of bronchial asthma.Methods One hundred and twenty nine cases of asthma patients were randomly divided into intervention group and control group. Both groups were given routine therapy ,while the intervention group was given psychological intervention,Symptom Check List-90(SCL-90) and Social Supporting Rating Scale(SSRS) were used to assess the effects of treatment. Results Before psychological interventions, factor value of SCL-90 were higher than the norm, as the value of SSRS were significantly lower than the norn ;after psychological interventions, the values of Somatization, Obsessive Compulsive, Interpersonal sensitivity, Depression,Anxiety, Phobic anxiety, Paranoid ideation of were significantly reduced ( P < 0. 05 ); while the value of SSRS were significantly higher than that of the control group ( P < 0.05 ). Conclusion On the basis of routine therapy, psychological interventions can effectively improve emotional status of asthmatic patients ,and promote the recovery of bronchial asthma.%目的 探寻支气管哮喘的心理社会因素,探索有效治疗支气管哮喘的心理干预方法.方法 本研究将129例支气管哮喘患者随机分为干预组和对照组,均给予药物治疗,干预组同时接受心理干预,采用症状自评量表和社会支持量表评估心理干预前后两组患者的治疗效果.结果 心理干预前,支气管哮喘患者的症状自评量表各因子分值高于常模,社会支持量表分值显著低于常模;心理干预后,患者症状自评量表的躯体化、强迫状态、人际关系、抑郁、焦虑、恐怖、偏执的因子分值显著降低(P<0.05),而社会支持量表分值显著高于治疗前(P<0.05).结论 在药物治疗的基础上,心理干预能明显改善支气管哮喘患者的心理指标,促进支气管哮喘的康复和治疗.

  13. Symptomatic improvement of bronchial asthma after surgical treatment of chronic rhinosinusitis%手术治疗慢性鼻窦炎对控制支气管哮喘发作疗效的初步观察

    Institute of Scientific and Technical Information of China (English)

    贺红斌; 潘松林; 官兵; 刘涛; 谢元春

    2012-01-01

    目的 探讨慢性鼻窦炎合并支气管哮喘患者在手术治疗慢性鼻窦炎后支气管哮喘的发作情况.方法 选取2001 ~2007年我院收治的慢性鼻窦炎且合并支气管哮喘的手术患者40例行鼻内镜下手术,术后平均随访(5.4±2.0)年,观察鼻窦炎术后哮喘发作情况.结果 术后1年随访结果显示,支气管哮喘治愈6例(15.0%),好转18例(45.0%);术后3年随访结果显示,支气管哮喘治愈18例(45.0%),好转14例(35.0%).结论 多数慢性鼻窦炎合并支气管哮喘患者经鼻内镜手术治疗后支气管哮喘症状明显改善,部分患者甚至可以治愈.%Objective To evaluate the relief of symptoms of bronchial asthma after the endoscopic sinus surgery in patients with asthma and chronic rhinosinusitis. Methods From 2001 to 2007, 40 patients suffering from asthma and chronic rhinosinusitis were given endoscopic sinus surgery. All the patients were followed up for at least 3 years after surgery. Results One year after surgery, the symptoms of bronchial asthma got disappeared in 6 ( 1 5 . 0 % ) and improved in 1 8 ( 4 5 . 0% ) . Three years after surgery , the symptoms got disappeared in 1 8 (45.0%) and improved in 14 (35. 0%). Conclusion After endoscopic sinus surgery, the symptoms of bronchial asthma can be relieved significantly in most patients with asthma and chronic rhinosinusitis. And some patients can be cured with operation.

  14. The Cause and Treatment of the Persistent State of Bronchial Asthma in Children%小儿支气管哮喘持续状态的发病诱因及治疗预防

    Institute of Scientific and Technical Information of China (English)

    王红梅

    2015-01-01

    目的:分析小儿支气管哮喘持续状态的发病诱因及治疗预防。方法选取我院接受治疗的小儿支气管哮喘持续状态患者80例进行临床研究,研究发病诱因,对全部患者行氨茶碱加足量激素的治疗措施。结果诱发小儿支气管哮喘持续状态的因素主要是呼吸道感染,其次是油漆、冷空气、煤烟和食用海鲜。结论支气管哮喘持续状态(SA)是哮喘的严重发作,找到发病诱因,采取预防措施是避免小儿患者因哮喘导致死亡的关键。在本次研究中对 SA 小儿患者行氨茶碱加足量激素治疗措施,达到满意的临床疗效。%Objective To analyze the pathogenesis of infantile bronchial asthma continuous state causes prevention and treatment. Methods 80 patients with infantile bronchial asthma patients with persistent state of clinical research were chosen in our hospital, study the triggers, in all patients with aminophylline and enough hormone treatment. Results Children with bronchial asthma induced factors of continuous state mainly respiratory tract infection, followed by paint, cold air, soot, and seafood. Conclusion The bronchus asthma persistent state (SA) is a severe asthma attack, find the triggers, take preventive measures is the key to avoid pediatric patients died as a result of asthma. In this study to SA pediatric patients with aminophylline and enough hormone treatment, achieve satisfactory clinical efficacy.

  15. Characteristics of phenotypes of elderly patients with asthma

    Directory of Open Access Journals (Sweden)

    Hiroyuki Sano

    2016-04-01

    Conclusions: Half of elderly patients with asthma are characterized by asthma-emphysema overlap. Our results showed that elderly patients with asthma who are smokers and have moderate or severe OAD are also likely to have emphysema.

  16. 老年支气管哮喘急性发作期的护理%Nursing Care of Acute Attack of Bronchial Asthma in the Elderly

    Institute of Scientific and Technical Information of China (English)

    杨芙蓉

    2014-01-01

    Objective To investigate the elderly patients with acute attack of bronchial asthma and nursing during the.Methods 52 cases of our hospital patients as the object of observation,communication,education on patients and nursing,psychological nursing.Results During hospitalization patients receive effective treatment. Conclusion Scientific and publicize the knowledge of prevention and control for patients,make patients and nursing understanding and trust, greatly improving the satisfaction of patients for nursing care.%目的:探讨老年支气管哮喘患者急性发作期间的护理。方法以我院收治的52例患者作为观察对象,对患者及陪护进行沟通、宣教,做好心理护理。结果患者住院期间得到有效治疗。结论对患者进行科学防治知识宣传,取得患者及陪护的理解和信任,大大提高了患者对护理的满意度。

  17. Compliance Research of Inhaled Corticosteroid Therapy for Bronchial Asthma%支气管哮喘患者吸入糖皮质激素治疗依从性研究

    Institute of Scientific and Technical Information of China (English)

    刘海燕

    2016-01-01

    目的:对支气管哮喘患者吸入糖皮质激素的依从性进行分析,进而促进支气管哮喘的预防与控制。方法选取我院收治的支气管哮喘并吸入糖皮质激素治疗的患者100例,对其吸入糖皮质激素治疗的依从性进行统计学分析。结果坚持吸入糖皮质激素治疗的有22例,依从率为22%,其余78例未按照医嘱用药,占78%。结论支气管哮喘激素吸入糖皮质激素治疗的依从性受多重因素影响,为提高患者的依从性,需要针对患者的实际情况,制定治疗方案。%Objective To discuss compliance research of inhaled corticosteroid therapy for Bronchial asthma.Methods In our hospital patients with bronchial asthma and inhaled corticosteroid therapy 100 patients in their hospital course of treatment with inhaled corticosteroid therapy adherence were statistically analyzed.Results Adhere to inhaled corticosteroid therapy in 22 cases, compliance was 22%, the remaining 78 cases did not follow prescription drugs, accounting for 78%.Conclusion Compliance of inhaled corticosteroid therapy for Bronchial asthma is inlfuenced by multiple factors. In order to improve the patient's compliance, treatment programs should be developed according to the actual situation of patients.

  18. 变应性鼻炎和哮喘患者血清IL-5、IL-15及IL-18的水平研究%Expression of IL-5 、IL-15 and IL-18 in sera of patients with allergic rhinitis and/or bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    刘颖慧; 蒋捍东

    2010-01-01

    目的 探讨IL-5、IL-15和IL-18在变应性鼻炎、支气管哮喘、变应性鼻炎合并哮喘疾病中的作用.方法 采用双抗体夹心ELISA测定法对33例支气管哮喘患者、35例变应性鼻炎患者、35例变应性鼻炎合并哮喘的患者及35例正常健康查体者血清中IL-5、IL-15和IL-18的水平进行检测.结果 支气管哮喘、变应性鼻炎、变应性鼻炎合并哮喘的患者血清中IL-5、IL-15和IL-18水平较正常对照组升高(P<0.01),IL-5、IL-15,IL-18水平在变应性鼻炎合并哮喘组均高于鼻炎组与和哮喘组;鼻炎组IL-5水平高于哮喘组(P=0.003),哮喘组IL-18水平高于鼻炎组(P=0.001).结论 IL-5、IL-15和IL-18参与了过敏性鼻炎和哮喘的发病过程;变应性鼻炎合并哮喘的炎症程度较高;哮喘和鼻炎因发病部位不同炎症反应也有不同.%Objective To explore the effect of IL-5, IL-15 and IL-18 in pathogenesis of patient with allergic rhinitis (AR) and bronchial asthma. Methods The serum samples were obtained from 33 patients with asthma,35 patients with AR, 35 patients with AR and BA, and 35 controls. The serum levels of IL-5,IL-15 and IL-18 were measured by ELISA. Results The levels of IL-5,IL-15 and IL-18 were greatly increased in all patient groups than the control group (P<0.01). The levels of IL-5 ,IL-15 and IL-18 were greatly increased in AR and BA group than the group of BA and the group of AR.The level of IL-5 in the group of AR was higher than that in the group of BA.(P=0.003). The level of IL-18 in the group of BA was higher than that in the group of AR( P=0.001 ). Conclusions IL-5 ,IL-15 and IL-18play a prominent role in the pathogenesis of AR and BA. Inflammations in the group of AR accompanying BA group are much higher. there is difference in inflammations between BA and AR.

  19. Patient and physician asthma deterioration terminology: results from the 2009 Asthma Insight and Management survey.

    Science.gov (United States)

    Blaiss, Michael S; Nathan, Robert A; Stoloff, Stuart W; Meltzer, Eli O; Murphy, Kevin R; Doherty, Dennis E

    2012-01-01

    Long-term achievement of asthma control is dependent in part on the use of mutually understandable asthma terminology in all verbal and written patient-physician communications. Using data from the Asthma Insight and Management (AIM) survey, the objective of this analysis is to provide a contemporary depiction of asthma deterioration terminology as used by current asthma patients and physicians in the United States. As part of the 2009 AIM survey, current asthma patients (≥12 years of age; weighted n = 2499) and physicians (n = 309) were queried about their recognition, understanding, and/or use of the terms "asthma attack," "asthma flare-up," and "asthma exacerbation" in telephone interviews. Nearly all patients had heard the term "asthma attack" (97%), but relatively few had heard the term "asthma exacerbation" (24%); 71% had heard "asthma flare-up." In contrast, physicians reported using the term "asthma attack" least (65%) and the term "asthma exacerbation" most (77%) when discussing asthma with their patients; 70% reported using "asthma flare-up." Among patients familiar with "asthma flare-up" and "asthma exacerbation" (n = 502), only 38% said that the terms mean the same thing; nearly all physicians (94%) said that the terms mean the same thing. Collectively, data from the AIM survey suggest that patients and physicians use different asthma deterioration terminology and, more importantly, that they do not necessarily understand each other's terms. Standardizing asthma deterioration terminology may help optimize asthma patient-physician communication to improve patient understanding of written asthma action plans and therefore, enhance patient outcomes.

  20. Allergy, asthma and the environment; Allergie, Asthma und Umwelt

    Energy Technology Data Exchange (ETDEWEB)

    Ring, J. [Klinik und Poliklinik fuer Dermatologie und Allergologie am Biederstein, Technische Univ. Muenchen (Germany); Gfesser, M. [Klinik und Poliklinik fuer Dermatologie und Allergologie am Biederstein, Technische Univ. Muenchen (Germany)

    1996-10-11

    Asthma is a chronic inflammatory disease of the airways. Asthma and other allergic diseases have increased in prevalence during the last decades in many industrialized countries. Among other hypotheses, the possible role of environmental pollutants has received much public and scientific attention. Some pollutants may modulate the different phases of allergic reactions. Inflammation is a critical feature in the pathogenesis of asthma and therefore, beside allergen avoidance, anti-inflammatory treatment is the first line therapy of asthma. Cysteinyl-leukotrienes are lipid mediators which appear to play a major role in the pathophysiology of asthma. Based on current data, it appears that leukotrience receptor antagonists have bronchodilative and anti-inflammatory effects and may therefore enrich the pharmacotherapeutic spectrum within the therapeutic concept of patient management in asthma. (orig.) [Deutsch] Asthma bronchiale ist eine entzuendliche Erkrankung der Atemwege. Epidemiologische Studien konnten eine deutliche Zunahme der Erkrankung in den letzten zwei Jahrzehnten aufzeigen. In der Entstehung von Allergien und Asthma bronchiale spielen Umwelteinfluesse eine grosse Rolle. Luftschadstoffe scheinen mit verschiedenen Allergie-Parametern bei der Sensibilisierung, Symptombildung und Chronifizierung zu interferieren. Da beim Asthma bronchiale neben der Bronchokonstriktion die Entzuendung der Bronchialschleimhaut eine besondere Rolle spielt, wird heute neben Allergenkarenz und prophylaktischen Massnahmen eine fruehzeitige antientzuendliche Asthmatherapie angestrebt. Cysteinyl-Leukotriene gehoeren zu den wirksamsten Entzuendungsmediatoren beim Asthma bronchiale. Leukotrien-Rezeptorantagonisten scheinen sowohl bronchodilatatorische als auch antientzuendliche Wirkungen zu haben und koennten so innerhalb eines Gesamtkonzeptes von antiallergischer und antiasthmatischer Therapie das pharmakotherapeutische Spektrum bereichern. (orig.)

  1. 子午流注纳子针法治疗支气管哮喘临床研究%Clinical Research of Nazi Method of Ziwu Liuzhu Acutherapy on Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    李雁; 葛兆希; 邵仲殿

    2012-01-01

    目的:观察子午流注纳子针法对中医临床疗效、哮喘控制及哮喘症状积分的影响.方法:将60例哮喘患者随机分为子午流注纳子针法组和常规针法组各30例,治疗4个疗程.观察针刺前后中医临床疗效、哮喘控制及哮喘症状积分并进行比较.结果:两组针法对中医临床疗效、哮喘控制及哮喘症状积分的改善有显著性差别,子午流注纳子针法组优于常规针法组.结论:子午流注纳子针法治疗支气管哮喘疗效优于常规针法.%Objective : To observe the clinical efficacy of Nazi method of Ziwu Liuzhu acutherapy on asthma control and asthma symptom score. Methods; 60 patients with asthma were randomly divided into Ziwu Liuzhu acutherapy group and conventional acupuncture group, 30 patients in each group accepted treatment for four courses. The TCM clinical efficacy, asthma control and asthma symptoms score were observed before and after the treatment. Results : The improvement of TCM clinical efficacy, asthma control and asthma symptom score of two groups were significantly different. Ziwu Liuzhu acutherapy group was superior to the conventional acupuncture group. Conclusion: Ziwu Liuzhu acutherapy is more effective than the conventional acupuncture on the treatment of bronchial asthma.

  2. [Rhino-bronchial syndrome].

    Science.gov (United States)

    Gani, F; Vallese, G; Piglia, P; Senna, G; Mezzelani, P; Pozzi, E

    2000-12-01

    A close anatomical and functional relationship between superior and inferior airways is well documented. A typical example is offered by the close relationship between allergic rhinitis and asthma whose close connection is documented by epidemiological and pathological data. The mechanisms which can explain this phenomenon are not fully known but naso-bronchial reflexes, mouth-breathing due to nasal obstruction and aspiration of nasal secretions seem all to be important. Moreover it has been recently proved that the treatment of rhinitis can improve the concomitant asthma thus confirming their relationship. Another less frequent association is between sinusitis and asthma. Such a connection seems to be frequent in patients suffering of atopic rhinitis but also in patients presenting a nasal obstruction of different nature such as deviations of the nasal septum, adenoid hypertrophy etc. Also in this case a correct medical or surgical treatment of sinusitis can improve asthma symptomathology. Finally a classic example of involvement of superior and inferior airways is represented by the syndrome of ASA intolerance. These patients in fact initially complain of rhinitis which afterwards is complicated by the onset of nasal polyposis and asthma which can prove clinically very severe. Nowadays, anyway, there is no evidence that the treatment of rhinitis or polypectomy can improve the clinical course of asthma. In conclusion, diseases of superior and inferior airways must be considered in strict connection and need the same global treatment.

  3. El asma bronquial y su asociación con los cambios de tiempo The bronchial asthma and its association with the changes in the weather

    Directory of Open Access Journals (Sweden)

    Tatiana de la Vega Pazitková

    2010-12-01

    weather changes. METHODS: the total of persons daily seen in emergence services of the nine polyclinics of Playa municipality due to bronchial asthma was registered according to charge slips and reports from the analysis unit and municipal health trends from January 1, 2007 to December 31, 2008. The datum obtained on the attendance of such patients was contrasted with the information offered by the bio-metereological forms maps. The frequency of cases by day and by month was registered in charts. For histogram intervals were created and the different polyclinics were located according the frequency intervals related to the attendance of patients to receive the health services. RESULTS: under conditions of atmospheric hyperoxia the daily occurrence of disease showed a value similar or higher to 150 % of the respective monthly mean thus evidencing a massive metereological-pathological response of study population. CONCLUSIONS: the meteorotropic effects associated with sudden weather changes may to provoke deleterious impacts on the human health.

  4. Effect of different formulations of glucocorticoid on the function of islet β cells of patients suffering from bronchial asthma and diabetes%不同剂型糖皮质激素对支气管哮喘合并糖尿病患者胰岛β细胞功能的影响

    Institute of Scientific and Technical Information of China (English)

    孙法凤; 罗冲

    2014-01-01

    目的:观察2型糖尿病合并支气管哮喘患者运用不同剂型糖皮质激素治疗后,对患者胰岛素敏感性和胰岛β细胞功能的影响情况。方法选择2009年1月至2012年1月枣庄市山亭区人民医院收治的,同时符合2型糖尿病诊断标准和支气管哮喘(慢性持续期)诊断标准的患者86例,随机分为两组,A 组采用吸入性糖皮质激素治疗,B 组采用口服糖皮质激素治疗。3个月后行口服葡萄糖耐量试验(OGTT)及胰岛素释放试验,计算稳态模型胰岛β细胞功能指标(HOMA-β)和胰岛素抵抗指数(HOMA-IR)。结果A 组患者治疗前后胰岛素敏感性和胰岛β细胞功能无明显差异(P>0.05),B 组患者治疗前较治疗后胰岛素敏感性降低(P0.05). The function of pancreatic islet β cells and the sensitivity to insulin of patients in group B descended significantly after therapy (P<0.05). Conclusion There were no obvious influences on the function of pancreatic islet β cells and sensitivity to insulin of patients suffering from bronchial asthma and diabetes when treated with inhaled glucocorticoid. While there were obvious adverse effects when treated with oral 10 mg prednisone per day for 3 months.

  5. Asthma

    Directory of Open Access Journals (Sweden)

    Kim Harold

    2011-11-01

    Full Text Available Abstract Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA inhalers are preferred for most adults who fail to achieve control with ICS therapy. Allergen-specific immunotherapy represents a potentially disease-modifying therapy for many patients with asthma, but should only be prescribed by physicians with appropriate training in allergy. Regular monitoring of asthma control, adherence to therapy and inhaler technique are also essential components of asthma management. This article provides a review of current literature and guidelines for the appropriate diagnosis and management of asthma.

  6. The impact of indoor environmental factors on bronchial asthma%室内环境因素对支气管哮喘控制的影响

    Institute of Scientific and Technical Information of China (English)

    周为; 王蕾; 柯会星; 李洋

    2014-01-01

    Objective Identify home environmental exposures associated with poor control of bronchial asthma (asthma).Methods This cross-sectional study using the method of questionnaire investigation,selected in our hospital outpatient asthma visits with law during Oct.2009 to Mar.2012.The indoor environmental factors and asthma control level were recorded.Results Actually completed the questionnaire 440,there were 1 97 males,243 females,mean age (35.861 ± 10.063 )years.Among 440 patients,the percentages of controlled,partly controlled,uncontrolled asthma assessed by current symptom were 25.45%,57.27%,and 1 7.27% respectively.Using multivariate logistic regression analysis to remove the mutual influence of the results showed that:the use of carpets,keeping pet with hair,active smoking,passive smoking,nearly 1 year home decoration these 5 factors will have adverse effects on asthma control.At the same time,using weekly hot water wash bedding and anti-mite pillowcase or air purifier is any combination of the two methods will improve asthma control,predictive control level of 3 class risk relative risk were OR 0.322 (95% CI 0.1 1 6-0.892 )and OR 0.378 (95% CI 0.148-0.969 ). Conclusions Many environmental factors can have adverse effects on asthma control,but some control of environmental factors by means of the combination will help us better control of asthma.%目的:探讨室内环境影响因素对支气管哮喘(简称哮喘)的影响。方法采用现场问卷调查的方法,选择在我院哮喘门诊规律就诊的患者,调查室内环境因素对哮喘控制水平的影响。结果实际完成调查问卷440份,其中男性197例,女性243例,平均年龄(35.861±10.063)岁。达到哮喘控制人数112例(25.45%),部分控制人数252例(57.27%),未控制人数76例(17.27%)。采用多因素 Logistic回归分析去除相互影响后的结果显示:使用地毯、饲养带毛宠物、主动吸烟、被动吸烟、近1年内家庭装修这5个因素

  7. Clinical characteristics and treatment analysis of pregnancy combined with bronchial asthma acute attack%妊娠合并支气管哮喘急性发作的发病特点及治疗分析

    Institute of Scientific and Technical Information of China (English)

    幸似瑛; 谢文峰

    2015-01-01

    目的:探讨妊娠合并支气管哮喘急性发作的发病特点及治疗效果。方法:2011年10月-2014年10月收治妊娠合并支气管哮喘急性发作患者52例,根据自身病况,采用β2受体激动剂和糖皮质激素,补液、纠正水电解质平衡紊乱等治疗措施。回顾性分析其临床资料。结果:52例患者无并发症出现,胎儿在母体中各项体征正常。经过上述治疗之后,治疗总有效率96.1%。结论:妊娠促使部分患者支气管哮喘急性发作,半卧位、吸氧、静脉注射氨茶碱及肾上腺糖皮质激素等措施能有效控制严重支气管哮喘急性发作。%Objective:To explore the clinical characteristics and treatment effect of pregnancy combined with bronchial asthma acute attack.Methods:52 patients with pregnancy combined with bronchial asthma acute attack were selected from October 2011 to October 2014. According to the own conditions,52 patients were given β2 receptor agonist and corticosteroids,fluid infusion, correct water and electrolyte balance disorder and other treatment measures.The clinical data were retrospectively analyzed. Results:There was no complications,all signs of fetus in the womb are normal.After the above treatment,the total effective rate of patients was 96.1% .Conclusion:Pregnancy prompts part of patients with bronchial asthma acute attack,semi supine,oxygen inhalation,intravenous injection of aminophylline and adrenal cortex and other measures can effectively control the severe bronchial asthma acute attack.

  8. [Treatment of patients with acute asthma exacerbation].

    Science.gov (United States)

    Ostojić, Jelena; Mose, Jakov

    2009-01-01

    Asthma is a chronic inflammatory disease of the airways. The global prevalence of asthma ranges from 1% to 18% of the population, so it remains a common problem with enormous medical and economic impacts. In majority of patients, asthma can be well controlled with simple regimens of inhaled anti-inflammatory and bronchodilating medications. However, some patients tend to suffer from poorly controlled disease in terms of chronic symptoms with episodic severe exacerbations. Major factors that may be related to the emergency department visits and hospitalisation include prior severe attacks, nonadherence to therapeutic regimens, inadequate use of inhaled corticosteroids, poor self-management skills, frequent use of inhaled short-acting beta-agonists, cigarette smoking, poor socioeconomic status and age over 40 years. Severe exacerbations of asthma are life-threatening medical emergencies and require careful brief assesment, treatment according to current GINA (Global Initiative for Asthma) guidelines with periodic reassesment of patient's response to therapy usually in an emergency department.

  9. Small airway function changes and its clinical significance of asthma patients in different clinical phases

    Institute of Scientific and Technical Information of China (English)

    Yan-Hui Zhou; Jun-Ti Lu

    2016-01-01

    Objective:To observe the small airways function changes of asthmatic patients in different clinical phases and to discuss its clinical significance.Methods:A total of 127 patients diagnosed as asthma were selected randomly and pulmonary function (PF) of them was determined by conventional method. Then they were divided into A, B and C group based on PF results. All 34 patients in A group suffered from acute asthma attack for the first time. All 93 patients in B group had been diagnosed as asthma but in remission phase. C Group was regarded as Control group with 20 healthy volunteers. Then FEV1, FEF50%, FEF75% levels of patients in each group were analyzed, and FEV1, FEF75% and FEF50% levels of patients in each group were compared after bronchial dilation test.Results:It was found that most patients in group A and B had abnormal small airways function, and their small airways function was significantly different compared with that of group C (P<0.01). In addition, except for group C, FEF75%, FEF50% levels in A and B group were improved more significantly than FEV1 levels (P<0.01).Conclusions:Asthma patients in acute phase all have abnormal small airways function. Most asthma patients in remission phase also have abnormal small airways function. After bronchial dilation test, whether patients in acute phase or in remission phase, major and small airways function of them are improved, but improvement of small airways function is weaker than that of major airways. This indicates that asthma respiratory tract symptoms in different phases exists all the time and so therapeutic process is needed to perform step by step.

  10. PILL Series. The ‘problematic’ asthma patient

    OpenAIRE

    Kui, Swee Leng; How, Choon How; Koh, Jansen

    2015-01-01

    Asthma is a reversible chronic inflammatory disorder of the airways that can be effectively controlled without causing any lifestyle limitation or burden on the quality of life of the majority of asthma patients. However, persistently uncontrolled asthma can be frustrating for both the patient and the managing physician. Patients who fail to respond to high-intensity asthma treatment fall into the category of ‘problematic’ asthma, which is further subdivided into ‘difficult’ asthma and ‘sever...

  11. Antinuclear Antibodies in Asthma Patients- A Special Asthma Phenotype?

    Directory of Open Access Journals (Sweden)

    Agache Ioana

    2009-03-01

    Full Text Available Several studies reported the appearance of asthma and autoimmune conditions in the same patient, but the clinical significance of this association was not yet assessed. One hundred asthmatic patients were observed for one year evolution with death, severe exacerbations, intake of > 1000 micrograms of beclometasone or equivalent (high ICS and FEV1 decline >100 ml, in relation with ANA (ELISA, sputum and blood eosinophilia (EO, NSAID intolerance, BMI >25, chronic rhinosinusitis, smoking status and FEV1 After 1 year of observation, there were 5 deaths, 28 severe asthma exacerbations requiring hospitalisations, 24 cases requiring high inhaled corticosteroid intake, and 19 patients with fast FEV1 decline (>100 ml/year. Multiple regression analysis pointed out several different independent risk factors for severe asthma evolution: for death presence of ANA (P=0.037, NSAID intolerance (P100 ml ANA (P=0.006, sputum EO (P=0.037, BMI>25 (P=0.046 and NSAID intolerance (P=0.017The presence of ANA is an independent risk factor in asthma for evolution with death, severe exacerbations, high inhaled corticosteroid intake and FEV1 decline >100 ml.

  12. Effect of doxofylline on 75 cases of school-age children with severe bronchial asthma%多索茶碱治疗75例学龄儿童重症支气管哮喘的研究

    Institute of Scientific and Technical Information of China (English)

    李磊; 白科; 袁程远; 何亚薇

    2011-01-01

    目的 观察多索茶碱治疗学龄儿童重症支气管哮喘的疗效和不良反应.方法 将150例重症支气管哮喘患儿随机分为治疗组(多索茶碱,n=75)、对照组(氨茶碱,n=75),并辅以常规治疗.观察及比较两组患儿治疗前、后有效率、最大呼气高峰流速(PEF)、血气改变以及药物不良反应等.结果 与对照组相比,治疗组有效率、PEF及血气改变的差异有统计学意义(P<0.05).多索茶碱不良反应发生率明显小于氨茶碱.结论 多索茶碱治疗学龄儿童重症支气管哮喘较氨茶碱起效时间短、作用强、安全,可作为重症哮喘附加治疗方案的首选.%Objective To evaluate the effects and side effects of doxofylline on school age children with severe bronchial asthma. Methods 150 patients with severe bronchial asthma were randomly divided into two groups,the patients in one group(n= 75) were treated with doxofylline,whereas those in control group(n =75) were treated with aminophyline. All patients were treated with conventional therapy. According to the clinic manifestation,peak expiratory flow(PEF) ,and the change of blood gas analysis,the effects of doxofylline were compared with aminophyline. And the side effects of doxofylline were observed. Results The differences of the efficiency,PEF,the change of blood gas analysis between the two groups were statistically significant(P<0.05). Compared with aminophylline,the side effects of doxofylline were moderate. Conclusion In the treatment of severe bronchial asthma in school age children,the doxofylline is characteristic with shorter onset time,more effective and safer than aminophyline. So doxofyl line may be the first choice in the additional treatment of severe bronchial asthma.

  13. The Control Level of Bronchial Asthma in Dependence of Genotype by BCL1 Polymorphism of Glucocorticoids Receptor Gene and Body Mass Index

    Directory of Open Access Journals (Sweden)

    Vladyslava V. Kmyta

    2014-09-01

    Full Text Available The frequency of allelic genotypes by BclI polymorphism glucocorticoids receptor gene (GR had been studied in dependence of the control level of bronchial asthma (BA and body mass index (BMI, and also- connection between those indicators. 188 patient with BA and 95 almost healthy humans were investigated. Determination of single nucleotide BclI polymorphism GR gene performed by the method of polymerase chain reaction with following analyze of the length of restriction fragments. Our studies demonstrated connection between BA control, BclI polymorphism GR gene and BMI. Proved, that distribution C/C, C/G and G/G genotypes by BclI polymorphism in patients with BA showed reliable difference between patients with different BMI and connection G/G genotype with obesity. The reliable difference in distributing of genotype in dependence of BA control level has been proved: with controlled BA reliably often met C/C genotype, without control – G/G genotype. Therefore, proved, that frequency G/G genotype by BclI polymorphism GR gene in patients with BA with obesity and absence of control for the flowing of disease is reliably higher, that confirmed the role of this genotype, likewise, in obesity occurrence, so in absence of the control of disease.

  14. Assessment of association of exposure to polycyclic aromatic hydrocarbons with bronchial asthma and oxidative stress in children: A case control study

    Directory of Open Access Journals (Sweden)

    Suresh Ram

    2009-01-01

    Full Text Available Background: Polycyclic aromatic hydrocarbons (PAH originate from the incomplete combustion of organic matter and ambient air pollution by these is increasing. There is also an increase in the global prevalence of asthma, for which environmental pollution has been recognized as one of the important factors. Exposure to pollutants and other allergens induces chronic airway inflammation by generation of reactive oxygen species, causing oxidative stress. Therefore, the objective of the present study was to assess association, if any, between exposure to PAH and asthma as well as oxidative stress in children. Method: In this hospital-based case control study, cases of bronchial asthma aged 1-14 years and healthy matched controls were included. Oxidative stress was measured by assessing the levels of enzymes catalase, superoxide dismutase, malondialdehyde (MDA, and reduced glutathione (GSH. Results : Forty-two cases and 20 controls were enrolled. Mean blood level of phenanthrene, a PAH, was 63.11 ppb ± 115.62 and 4.20 ppb ± 10.68 ppb in cases and controls, respectively ( P = 0.02. Mean blood levels of GSH was significantly lower in cases and controls (27.39 mg/ml ± 11.09 versus 47.39 g/ml ± 13.83; P -value = 0.001. Likewise, mean blood level of MDA in nanomole/ml was significantly higher in asthma as compared with controls (12.85 ± 5.40 versus 8.19 ± 5.16; P -value = 0.002, suggestive of increased oxidative stress. Conclusions: Because elevated blood level of phenanthrene is associated with bronchial asthma as well as with oxidative stress, measures to reduce exposure to PAH may possibly lead to reduced incidence and severity of bronchial asthma.

  15. 支气管哮喘动物模型制备的研究%The Studies on Preparation of Animal Model with Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    曹珊珊

    2012-01-01

    支气管哮喘是一种常见多发病,哮喘动物实验模型的建立在研究本病的发病原因、机制及防治方面有着极其重要的意义.笔者主要就哮喘动物模型的相关内容进行了概述.%Bronchial asthma is a common and frequently encountered disease. The establishment of animal experimental model on asthma had extremely important significance in aetiological agent,mechanism and preventive treatment of asthma. A brief review relating to animal modles on asthma was summarized in this paper.

  16. Endoscopic bronchial valve treatment: patient selection and special considerations

    Directory of Open Access Journals (Sweden)

    Eberhardt R

    2015-10-01

    Full Text Available Ralf Eberhardt,1,2 Daniela Gompelmann,1,2 Felix JF Herth,1,2 Maren Schuhmann1 1Pneumology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, 2Translational Lung Research Center, Member of the German Center for Lung Research, Heidelberg, Germany Abstract: As well as lung volume reduction surgery, different minimally invasive endoscopic techniques are available to achieve lung volume reduction in patients with severe emphysema and significant hyperinflation. Lung function parameters and comorbidities of the patient, as well as the extent and distribution of the emphysema are factors to be considered when choosing the patient and the intervention. Endoscopic bronchial valve placement with complete occlusion of one lobe in patients with heterogeneous emphysema is the preferred technique because of its reversibility. The presence of high interlobar collateral ventilation will hinder successful treatment; therefore, endoscopic coil placement, polymeric lung volume reduction, or bronchoscopic thermal vapor ablation as well as lung volume reduction surgery can be used for treating patients with incomplete fissures. The effect of endoscopic lung volume reduction in patients with a homogeneous distribution of emphysema is still unclear and this subgroup should be treated only in clinical trials. Precise patient selection is necessary for interventions and to improve the outcome and reduce the risk and possible complications. Therefore, the patients should be discussed in a multidisciplinary approach prior to determining the most appropriate treatment for lung volume reduction. Keywords: lung emphysema, valve treatment, collateral ventilation, patient selection, outcome

  17. Postural stability in school-age children with mild bronchial asthma disease (a pilot study).

    Science.gov (United States)

    Kovacikova, Zuzana; Neumannova, Katerina; Bizovska, Lucia; Rydlova, Jana; Siska, Martin; Janura, Miroslav

    2016-01-01

    This study assessed the postural stability in children with asthma using balance tests under conditions of a comfortable foot placement and with a foot placement provoking instability. A group of 10 school children from 8 to 10 years old with mild intermittent asthma and 10 healthy children of the same age range performed four balance tests in a randomized order: preferred stance, adjusted stance, and tandem stance each under both conditions of eyes opened (EO) and eyes closed (EC), as well as a one-legged stance with eyes-opened conditions. To determine postural stability, the center of pressure (CoP) movement was recorded. Basic stabilographic parameters were calculated: CoP velocity in the anterior-posterior direction, CoP velocity in the medial-lateral direction, and the total CoP velocity. Statistically significant differences between the groups were found only for the one-legged stance. Significantly greater anterior-posterior CoP velocity (p = 0.05) and total CoP velocity (p = 0.03) were found in children with asthma when standing on the preferred foot. A significantly greater medial-lateral velocity (p = 0.02) was also found in the non-preferred foot of children with asthma. We can conclude that standing on one leg might be an appropriate test with which to identify balance differences between young children with mild intermittent asthma and healthy children.

  18. A study on the effects of herbal acupuncture with Liriopis Tuber extract on airway inflammation in the mouse induced with bronchial asthma

    Directory of Open Access Journals (Sweden)

    Young-Whan Park

    2001-02-01

    Full Text Available Objectives: Herbal acupuncture has been administered with Liriopis Tuber extract on the point of BL 13 (Pyesu to treat bronchial asthma and a certain degree of clinical benefits have been observed but lacking scientific substantiation. Methods: The present report describes on Th1 cytokine (Interleukin-2, Interferon-gamma, Th2 cytokine, (Interleukin-4, Interleukin-5, and IL-12 in bronchoalveolar lavage fluid (ELISA. Five groups were devised to study the effects of herbal acupuncture with Liriopis Tuber extract at BL 13 (Pyesu for airway inflammation in the mouse model with bronchial asthma. Results shows that herbal acupuncture with Liriopis Tuber extract at BL 13 increased Th1 cytokine (Interleukin-2 in allergic sensitization and allergic challenge, and decreased Th2 cytokine (Interleukin-2, Interleukin-5 in allergic sensitization.

  19. Clinical Profile, Co-Morbidities and Health Related Quality of Life in Pediatric Patients with Allergic Rhinitis and Asthma

    OpenAIRE

    Keya R. Lahiri, Milind S. Tullu* and Rachna Kalra

    2010-01-01

    Background: Co-existence of allergic rhinitis (AR) and bronchial asthma (BA) is well known. We planned to study the clinical profile of patients with AR & BA, the associated co-morbidities and the effect of AR &/ or BA on health related quality of life (HRQOL) in Pediatric patients. Methods: Patients attending the Pediatric out-patients department and Pediatric Chest Clinic of tertiary care center were enrolled. The sample size included 100 subjects with BA & AR (Group 1) with control groups ...

  20. Flow cytometric analysis of lymphocytes and lymphocyte subpopulations in induced sputum from patients with asthma

    Directory of Open Access Journals (Sweden)

    Yutaro Shiota

    2000-01-01

    Full Text Available Study objectives were to compare the numbers of lymphocytes and lymphocyte subpopulations in induced sputum from asthmatic patients and from healthy subjects, and to determine the effect of inhaled anti-asthmatic steroid therapy on these cell numbers. Hypertonic saline inhalation was used to non-invasively induce sputum samples in 34 patients with bronchial asthma and 21 healthy subjects. The sputum samples were reduced with dithioerythritol and absolute numbers of lymphocytes and lymphocyte subpopulations were assessed by direct immunofluorescence and flow cytometry. To assess the effect of beclomethasone dipropionate (BDP on induced sputum, numbers of lymphocytes and lymphocyte subpopulations in sputum also were evaluated after 4 weeks of BDP inhalation treatment in seven asthmatic patients. An adequate sample was obtained in 85.3% of patients with asthma and in 79.2% of the healthy subjects. Induced sputum from patients with asthma had increased numbers of lymphocytes (P = 0.009; CD4+ cells (P = 0.044; CD4+ cells-bearing interleukin-2 receptor (CD25; P = 0.016; and CD4+ cells bearing human histocompatibility leukocyte antigen (HLA-DR (P = 0.033. CD8+ cells were not increased in asthmatic patients. In patients treated with inhaled steroids, numbers of lymphocytes, CD4+ cells, CD25-bearing CD4+ cells and HLA-DR-bearing CD4+ cells in sputum decreased from pretreatment numbers (P = 0.016, 0.002, 0.003 and 0.002, respectively. Analysis of lymphocytes in induced sputum by flow cytometry is useful in assessing bronchial inflammation, and activated CD4+ lymphocytes may play a key role in the pathogenesis of airway inflammation in bronchial asthma.

  1. Cardiac arrhythmias in adult patients with asthma

    DEFF Research Database (Denmark)

    Warnier, Miriam J; Rutten, Frans H; Kors, Jan A;

    2012-01-01

    OBJECTIVE: The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias and electrocardio......OBJECTIVE: The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias...... and electrocardiographic characteristics of arrhythmogenicity (ECG) and to explore the role of β2-mimetics. METHODS: A cross-sectional study was conducted among 158 adult patients with a diagnosis of asthma and 6303 participants without asthma from the cohort of the Utrecht Health Project-an ongoing, longitudinal, primary...... or flutter). Secondary outcomes were tachycardia, bradycardia, PVC, atrial fibrillation or flutter, mean heart rate, mean corrected QT (QTc) interval length, and prolonged QTc interval. RESULTS: Tachycardia and PVCs were more prevalent in patients with asthma (3% and 4%, respectively) than those without...

  2. Role of psychiatric disorders and irritable bowel syndrome in asthma patients

    Directory of Open Access Journals (Sweden)

    Ayse Yilmaz

    2011-01-01

    Full Text Available OBJECTIVES: The goals of the study were the following: 1 to determine the frequency of psychiatric disorders and irritable bowel syndrome in patients with asthma and 2 to compare the frequency of these disorders in patients with asthma to their frequency in healthy controls. INTRODUCTION: Patients with asthma have a higher frequency of irritable bowel syndrome and psychiatric disorders. METHODS: We evaluated 101 patients with bronchial asthma and 67 healthy subjects. All subjects completed the brief version of the Bowel Symptoms Questionnaire and a structured clinical interview for DSM-IV axis disorders (SCID-I/CV. RESULTS: There were 37 cases of irritable bowel syndrome in the group of 101 stable asthma patients (36.6% and 12 cases in the group of 67 healthy subjects (17.9% (p = 0.009. Irritable bowel syndrome comorbidity was not related to the severity of asthma (p = 0.15. Regardless of the presence of irritable bowel syndrome, psychiatric disorders in asthma patients (52/97; 53.6% were more common than in the control group (22/63, 34.9% (p = 0.02. Although psychiatric disorders were more common in asthma patients with irritable bowel syndrome (21/35, 60% than in those without irritable bowel syndrome (31/62, 50%, the difference was not significant (p = 0.34. In asthma patients with irritable bowel syndrome and psychiatric disorders, the percentage of forced expiratory volume in 1 s (FEV1 was lower than it was in those with no comorbidities (p = 0.02. CONCLUSIONS: Both irritable bowel syndrome and psychiatric disorders were more common in asthma patients than in healthy controls. Psychiatric disorders were more common in asthma patients with irritable bowel syndrome than in those without irritable bowel syndrome, although the differences failed to reach statistical significance. In asthma patients with IBS and psychiatric disorders, FEV1s were significantly lower than in other asthma patients. It is important for clinicians to accurately

  3. 小儿支气管哮喘与肺炎支原体感染的关系%The relationship between children bronchial asthma and mycoplasma pneumoniae infection

    Institute of Scientific and Technical Information of China (English)

    仇世蓉

    2015-01-01

    effects of two groups were compared.Results:The MP-IgM positive rate of the control group was 20% ;the MP-IgM positive rate of the observation group was 48% ;the difference was statistically significant(P<0.05).The effective rate of the conventional bronchial asthma treatment group was 37.5%;the effective rate of the conventional bronchial asthma treatment and azithromycin treatment group was 83.3%;the difference was statistically significant(P<0.05).Conclusion:The relationship between the children mycoplasma pneumoniae infection and bronchial asthma is close,and the children with bronchial asthma should be given routine detection of mycoplasma pneumoniae infection situation.The positive patients are given against pneumonia mycoplasma infection according to the asthma conventional treatment at the same time,which can enhance the curative effect.

  4. Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness

    NARCIS (Netherlands)

    L.M. van den Toorn (Leon); J-B. Prins (Jan-Bas); S.E. Overbeek (Shelley); H.C. Hoogsteden (Henk); J.C. de Jongste (Johan)

    2000-01-01

    textabstractSymptoms of atopic asthma often decrease or even seem to disappear around puberty. The aim of this study was to investigate whether this so-called clinical remission is accompanied by remission of airway inflammation, since symptoms relapse in a substantial

  5. Prevalence of asthma and bronchial hyperreactivity in Danish schoolchildren: no change over 10 years

    DEFF Research Database (Denmark)

    Zilmer, M; Steen, Np; Zachariassen, G

    2011-01-01

    questionnaire on asthma and respiratory symptoms combined with a 6-min free running test with peak expiratory flow rate (PEFR) measurement (n = 1051, response rate 89.3%). Results were compared with those of a similar study in the same area from 1990 to 1991. Main outcome measures were current physician...

  6. Integrated Nursing Intervention for Bronchial Asthma in Children%小儿支气管哮喘整体护理干预体会

    Institute of Scientific and Technical Information of China (English)

    高秀梅

    2015-01-01

    Objective To evaluate the clinical ef icacy and feasibility of implementation of the integrated nursing in children with bronchial asthma. Methods A retrospective analysis was conducted in 112 patients with bronchial asthma in our hospital, divided into two groups by double-blind, the control group received routine pediatric bronchial asthma care measures, research group received integrated nursing, taking a self-designed questionnaire to evaluate and compare the clinical efficacy. Results Medication compliance, knowledge and awareness of disease significantly increased(P<0.05), the study group was significantly greater than control group(P<0.01). In study group, cough relapse rate was significantly less than the control group(P<0.05), treatment satisfaction was significantly higher(P<0.05). Study group treatment ef iciency was 95.0%, significantly higher than 88.5%in the control group(P<0.05). Conclusion Implementation of integrated nursing intervention can improve lung function in children, improve treatment and care satisfaction, shorter hospital stays.%目的:探讨在小儿支气管哮喘护理中实施整体护理方案的临床疗效及可行性。方法回顾性分析我院收治112例支气管哮喘患儿临床资料,采取随机双盲法分为研究组和对照组,对照组采取儿科支气管哮喘常规护理措施,研究组给予整体护理,采取自行设计的调查问卷评价,并比较临床疗效。结果两组经护理干预后用药依从性、疾病知识知晓率均较干预前提高(P<0.05),但研究组上升幅度大于对照组(P<0.01)。研究组护理干预后住院天数、咳嗽复发率均少于对照组(P<0.05),护理满意度高于对照组(P<0.05)。研究组治疗有效率95.0%,高于对照组88.5%(P<0.05)。结论对支气管哮喘患儿实施整体护理干预,能有效改善患儿肺功能,提高治疗效果和护理满意度,缩短住院时间,利于患儿早日出院。

  7. Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach

    Directory of Open Access Journals (Sweden)

    Baur Xaver

    2012-09-01

    Full Text Available Abstract Background Respiratory irritants represent a major cause of occupational obstructive airway diseases. We provide an overview of the evidence related to irritative agents causing occupational asthma or occupational COPD. Methods We searched MEDLINE via PubMed. Reference lists of relevant reviews were also screened. The SIGN grading system was used to rate the quality of each study. The modified RCGP three-star system was used to grade the body of evidence for each irritant agent regarding its causative role in either occupational asthma or occupational COPD. Results A total of 474 relevant papers were identified, covering 188 individual agents, professions or work-sites. The focus of most of the studies and the predominant diagnosis was occupational asthma, whereas occupational COPD arose only incidentally. The highest level assigned using the SIGN grading was 2+ (well-conducted systematic review, cohort or case–control study with a low risk of confounding or bias. According to the modified RCGP three-star grading, the strongest evidence of association with an individual agent, profession or work-site (“**” was found for 17 agents or work-sites, including benzene-1,2,4-tricarboxylicacid-1,2-anhydride, chlorine, platinum salt, isocyanates, cement dust, grain dust, animal farming, environmental tobacco smoke, welding fumes or construction work. Phthalic anhydride, glutaraldehyde, sulphur dioxide, cotton dust, cleaning agents, potrooms, farming (various, foundries were found to be moderately associated with occupational asthma or occupational COPD (“*[+]”. Conclusion This study let us assume that irritant-induced occupational asthma and especially occupational COPD are considerably underreported. Defining the evidence of the many additional occupational irritants for causing airway disorders will be the subject of continued studies with implications for diagnostics and preventive measures.

  8. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial.

    Science.gov (United States)

    Vempati, Ramaprabhu; Bijlani, Ramesh Lal; Deepak, Kishore Kumar

    2009-07-30

    There is a substantial body of evidence on the efficacy of yoga in the management of bronchial asthma. Many studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmonary functions, quality of life and reduction in airway hyper-reactivity, frequency of attacks and medication use. In addition, a few studies have attempted to understand the effects of yoga on exercise-induced bronchoconstriction (EIB) or exercise tolerance capacity. However, none of these studies has investigated any immunological mechanisms by which yoga improves these variables in bronchial asthma. The present randomized controlled trial (RCT) was conducted on 57 adult subjects with mild or moderate bronchial asthma who were allocated randomly to either the yoga (intervention) group (n = 29) or the wait-listed control group (n = 28). The control group received only conventional care and the yoga group received an intervention based on yoga, in addition to the conventional care. The intervention consisted of 2-wk supervised training in lifestyle modification and stress management based on yoga followed by closely monitored continuation of the practices at home for 6-wk. The outcome measures were assessed in both the groups at 0 wk (baseline), 2, 4 and 8 wk by using Generalized Linear Model (GLM) repeated measures followed by post-hoc analysis. In the yoga group, there was a steady and progressive improvement in pulmonary function, the change being statistically significant in case of the first second of forced expiratory volume (FEV1) at 8 wk, and peak expiratory flow rate (PEFR) at 2, 4 and 8 wk as compared to the corresponding baseline values. There was a significant reduction in EIB in the yoga group. However, there was no corresponding reduction in the urinary prostaglandin D2 metabolite (11beta prostaglandin F2alpha) levels in response to the exercise challenge. There was also no significant change in serum eosinophilic cationic protein levels during

  9. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Bijlani Ramesh

    2009-07-01

    Full Text Available Abstract Background There is a substantial body of evidence on the efficacy of yoga in the management of bronchial asthma. Many studies have reported, as the effects of yoga on bronchial asthma, significant improvements in pulmonary functions, quality of life and reduction in airway hyper-reactivity, frequency of attacks and medication use. In addition, a few studies have attempted to understand the effects of yoga on exercise-induced bronchoconstriction (EIB or exercise tolerance capacity. However, none of these studies has investigated any immunological mechanisms by which yoga improves these variables in bronchial asthma. Methods The present randomized controlled trial (RCT was conducted on 57 adult subjects with mild or moderate bronchial asthma who were allocated randomly to either the yoga (intervention group (n = 29 or the wait-listed control group (n = 28. The control group received only conventional care and the yoga group received an intervention based on yoga, in addition to the conventional care. The intervention consisted of 2-wk supervised training in lifestyle modification and stress management based on yoga followed by closely monitored continuation of the practices at home for 6-wk. The outcome measures were assessed in both the groups at 0 wk (baseline, 2, 4 and 8 wk by using Generalized Linear Model (GLM repeated measures followed by post-hoc analysis. Results In the yoga group, there was a steady and progressive improvement in pulmonary function, the change being statistically significant in case of the first second of forced expiratory volume (FEV1 at 8 wk, and peak expiratory flow rate (PEFR at 2, 4 and 8 wk as compared to the corresponding baseline values. There was a significant reduction in EIB in the yoga group. However, there was no corresponding reduction in the urinary prostaglandin D2 metabolite (11β prostaglandin F2α levels in response to the exercise challenge. There was also no significant change in serum

  10. Diagnostic value and influencing factors of fractional exhaled nitric oxide in suspected asthma patients.

    Science.gov (United States)

    Wang, Yubo; Li, Li; Han, Rui; Lei, Wenhui; Li, Zhongyan; Li, Kunlin; Kang, Jun; Chen, Hengyi; He, Yong

    2015-01-01

    To explore the critical value and possible influencing factors of fractional exhaled nitric oxide (FeNO) in suspected asthma patients. 923 suspected asthmatics consecutively referred to our hospital during December 2012 to July 2014 were selected. All cases were carried out FeNO measurement at first; next, spirometry, bronchoprovocation tests or bronchodilation tests were used to confirm or exclude asthma. Receiver operating characteristic curve (ROC) was used to determine the best cut-off value of FeNO for asthma diagnosis. In bronchoprovocation test, 125 cases were diagnosed as asthma, other 283 were non-asthmatics. FeNO levels of asthmatics were significantly higher than non-asthmatics (median, 64.8 ppb vs. 27.9 ppb, Pgroup of patients, 64 ppb was the best cut-off value of FeNO to identify asthma with sensitivity of 52.0% and specificity of 94.35%. In bronchodilation test, 185 patients were diagnosed as asthma, other 330 were non-asthmatics. FeNO levels of asthmatics were significantly higher than non-asthmatics (median, 60.6 ppb vs. 29.05 ppb, Pppb was the best cut-off value of FeNO to identify asthma with sensitivity of 72.43% and specificity of 74.85%. Influencing factors analysis showed that sex was an independent factor affecting patients' FeNO level. FeNO was an effective auxiliary diagnosis method for bronchial asthma. 64 ppb and 41 ppb was the best cut-off value of FeNO to identify asthma in bronchoprovocation test or bronchodilation test, respectively. Sex was an independent factor affecting patients' FeNO level.

  11. Remodelamento brônquico na asma Bronchial remodeling in asthma

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    THAIS MAUAD

    2000-04-01

    Full Text Available É sabido que certos pacientes asmáticos apresentam perda parcial e irreversível da função respiratória ao longo do tempo. Postula-se que o processo inflamatório crônico em vias aéreas, característico da doença, poderia, através da liberação de diversos mediadores inflamatórios, ocasionar alterações estruturais irreversíveis nas vias aéreas e conseqüente piora da broncoconstrição, contribuindo assim para o fenômeno de perda de função pulmonar. A este processo creditou-se o nome de remodelamento brônquico. Nesta revisão descrevem-se os mecanismos propostos para o remodelamento brônquico, o papel dos diversos mediadores inflamatórios envolvidos e as diversas alterações patológicas observadas em vias aéreas asmáticas. Para cada alteração estrutural descrita, discute-se a possível conseqüência funcional. O entendimento do remodelamento brônquico é importante para o melhor manejo dos pacientes com asma e para a prevenção da deterioração funcional definitiva.The relationship between structure and function in asthma has been extensively studied. All the compartments of the airway have been shown to have some structural alterations contributing to functional defects. The structural alterations are thought to be a consequence of the chronic inflammation present in asthmatic airways, leading ultimately to remodeling. The decline of the ventilatory function over time in some asthmatic patients may be a consequence of airway remodeling. In this review, the authors describe the phenomena leading to airway remodeling and discuss the role of inflammatory mediators involved in this process. The structural alterations of the asthmatic airways are presented and the possible correlated functional defects are discussed.

  12. 门诊支气管哮喘患者就诊情况分析%Investigation on the visit clinic of outpatients with bronchial asthma in respiratory department

    Institute of Scientific and Technical Information of China (English)

    左震华; 管希周

    2014-01-01

    [ABSTRACT]Objective: To investigate regularity of medical visit and medication of the outpatients with bronchial asthma, in order to provide reference for improving work quality in clinic.Methods: A total of 132 outpatients with bronchial asthma collected from our hospital during January 25, 2013 and May 31, 2013 were investigated. According to the history inquiry and outpatient medical records review, the patients were divided into two groups, regular visit group and intermittent visit group. The education background, frequencies of medical visit, treatment, asthma knowledge education, and pulmonary function test of the patients with bronchial asthma were investigated.Results:There were 76 patients in intermittent visit group, and 56 patients in regular visit group. The main visit reason for irregular visit group was asthma exacerbation. Only 24.2% of the patients regularly received pulmonary function test. The number of patients receiving the asthma education accounted for 42.0%, the numbers of patients with bachelor degree or above in intermittent visit group and regular visit group accounted for 38.1%, 73.2%, respectively. Conclusion: Delayed diagnosis, irregular treatment, and under application of pulmonary function test are common defects in management of asthma. It is important to strengthen the education of asthma for patients and doctor-patient communication to better control the disease.%目的:了解门诊支气管哮喘患者的就诊规律及用药情况等,以期为临床工作质量提高提供参考。方法:对我院呼吸科军人门诊2013年1月25日–5月31日期间就诊的132例支气管哮喘患者进行调查,采用询问病史和复习门诊病历的方法,将调查病例分为两组,一组为规律就诊组,另一组为非规律就诊组。调查内容包括:教育背景、就诊规律、治疗情况、哮喘知识教育、肺功能定期复查情况等。结果:76例患者不规律就诊,56例患者为规律就诊

  13. DEVELOPMENT OF RESEARCHES ON THE TREATMENT OF BRONCHIAL ASTHMA WITH ACUPUNCTURE AND MOXIBUSTION

    Institute of Scientific and Technical Information of China (English)

    CUI Jian-mei; GAO Chang-ke; WANG Yu; WANG Yan; LIU Yan-yan; YANG Yong-qing

    2006-01-01

    Acu-moxibustion therapy is one of the commonly-used remedies for the prevention and treatment of asthma. In the present article, the authors review development of clinical studies on acu-moxibustion treatment of asthma in recent 5 years from ① changes of pulmonary function as forced expiratory volume in 1second (FEV1), forced vital capacity (FVC), FEV1 %, peak expiratory flow (PEF), maximum mid expiratory flow (MMEF), etc., ② changes of immune function as serum IgE, IgG, subgroups of T lymphocytes, inflammatory mediators, cytokines, etc, and ③ changes of the nervous system and related receptors including nitric oxide (NO), vasoactive intestinal peptide (VIP), substance P (SP), and cAMP/cGMP. Additionally, the authors also introduce the development of experimental researches from the effects of acu-moxibustion on ①inflammatory cells, ② nervous system and receptors, ③ patho-morphological changes of the lung tissue, and④ serology of acupuncture.

  14. Budesonide Suspension Liquid Atomization Treatment of Pregnancy With the Clinical Effect of Bronchial Asthma%布地奈德混悬液雾化治疗妊娠合并支气管哮喘的临床效果

    Institute of Scientific and Technical Information of China (English)

    齐力

    2015-01-01

    Objective Explore budesonide suspension liquid atomization treatment of pregnancy with the clinical effect of bronchial asthma. Methods Choose from August 2010 to August 2014 were pregnancy with a total of 50 patients with bronchial asthma, patients were randomly divided into observation group and control group, control group given conventional treatment, the observation group in the control group on the basis of combined with budesonide suspension liquid atomization treatment, compared two groups of patients with asthma disappear time disappear, chest tightness, wheezing sound time, length of hospital stay, therapy effectively. Results Comprehensive, compared two groups of patients with clinical treatment group total effective rate was 96%, control group total effective rate was 84%, two groups of data exists obvious difference, with statistical significance (P<0.05).Conclusion Budesonide suspension liquid atomization treatment of pregnancy with bronchial asthma, breathing difficulties, can improve patients relieve patients’pain, is worthy of application.%目的:探讨布地奈德混悬液雾化治疗妊娠合并支气管哮喘的临床效果。方法随机选择该院2010年8月—2014年8月收治的妊娠合并支气管哮喘患者共50例,将患者随机分为观察组、对照组,对照组给予常规的治疗,观察组在对照组的基础上结合布地奈德混悬液雾化治疗,对比两组患者气喘消失时间、胸闷消失时间、哮鸣音消失时间、住院时间、治疗有效率。结果对比两组患者临床治疗的综合情况,观察组总有效率为96%,对照组总有效率为84%,两组数据存在明显差异,具有统计学意义(<0.05)。结论布地奈德混悬液雾化治疗妊娠合并支气管哮喘患者,能改善患者呼吸困难,减轻患者痛苦,值得应用。

  15. Thunderstorm-associated bronchial Asthma: A forgotten but very present epidemic

    Directory of Open Access Journals (Sweden)

    Abdullah M Al-Rubaish

    2007-01-01

    Doctors should be aware of this phenomenon and the potential outbreak of asthma during heavy rains. A & E departments and ICU should be alert for possible rush of asthmatic admissions and reinforce ventilators and requirements of cardio-pulmonary resuscitation. Scientific approach should be adopted to investigate such outbreaks in the future and must include meteorological, bio-aerosole pollutants and chemical pollutant assessment. Regional team work is mandatory.

  16. Nasal polyps in patients with asthma: prevalence, impact, and management challenges

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    Langdon C

    2016-03-01

    Full Text Available Cristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS, 3Centre for Biomedical Research in Respiratory Diseases (CIBERES, Barcelona, Catalonia, SpainAbstract: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP often have coexisting asthma under the concept of “United Airway Disease”, being the combination of both diseases, which is one of the most challenging phenotypes to treat. Although clinicians have recognized this difficult-to-treat phenotype for many years, it remained poorly characterized. There is increasing epidemiological evidence linking chronic rhinosinusitis and asthma, but a good understanding of the pathophysiology and the combined management is still lacking. Bronchial asthma is more prevalent in patients who suffer chronic rhinosinusitis, while asthmatic patients have a greater prevalence of CRSwNP than patients without asthma. The effect of CRSwNP treatment, whether medical or surgical, in asthma is today less controversial after some studies have shown improvement of asthma after medical and/or surgical treatment of CRSwNP. However, direct comparisons between surgical and medical treatments are limited. Further randomized clinical trials are, however, still needed to better understand the management when both asthma and CRSwNP occur together. This review aims at summarizing the prevalence, impact, and management challenges regarding both asthma and CRSwNP. Keywords: chronic rhinosinusitis, asthma, united airways, rhinosinusitis, corticosteroids, sinus surgery

  17. Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction

    Institute of Scientific and Technical Information of China (English)

    KONG YanHua; SHI Qi; HAN Na; ZHANG Ling; ZHANG YuanYuan; GAO TongXin; CHENChen; LIYouLin

    2016-01-01

    ObjectiveTo investigate whether recuperating lung decoction (RLD) can modulate the composition of gut microbiota in rats during asthma treatment. MethodsFifteen Sprague-Dawley rats were divided randomly and equally into control group, model group, dexamethasone (DEX) group, RLD medium-dose group, and RLD high-dose group. The asthma model was established in all groups, except for the control group. The rats in the DEX and RLD groups were treated orally with DEX and RLD, respectively. The rats in the control and model groups were treated orally with 0.9% saline. The intestinal bacterial communities were compared among groups using 16S rRNA gene amplification and 454 pyrosequencing. ResultsThe microbial flora differed between the control and model groups, but the flora in the RLD groups was similar to that in the control group. No significant differences were observed between the RLD high-dose and medium-dose groups. RLD treatment resulted in an increase in the level beneficial bacteria in the gut, such asLactobacillusandBifidobacteriumspp. ConclusionOral administration of RLD increased the number of intestinal lactic acid-producing bacteria, such as Lactobacillus andBifidobacterium, in asthma model rats.

  18. The Effect of Glucocorticoids on Bone Mass in Patients with Asthma and Chronic obstructive Pulmonary Disease

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    Evrim Karadağ Saygı

    2005-06-01

    Full Text Available Inhaled corticosteroids and bronchodilators have become a key element in the maintenance treatment of bronchial asthma and chronic obstructive pulmanory disease (COPD. It is well known that long-term systemic steroid use causes osteoporosis, whereas inhaled corticosteroids and bronchodilators have been discussed to be cause of such side-affect. The aim of this study was to detect the effect of long term inhaled/oral steroids and bronchodilators on bone mineral density (BMD with asthma and COPD. Fifty-three patients with bronchial asthma (n=44 and COPD (n=9 were enrolled in this study. BMD were measured and risk factors for osteoporosis were detected. BMD measurements of lumbar area of the spine (L2-4, neck of femur and femoral ward’s triangle zone were performed by the dual energy x-ray absorptiometer (LUNAR. 53 patients evaluated in three groups according to treatment type; 26 patients were using inhaled corticosteroids and bronchodilators (group 1, 18 patients were using only bronchodilators (group 2 and 9 patients were using (group 3 oral corticosteroids and bronchodilators. There were significant differences between group 3 and other two groups in terms of BMD, T and Z scores of the lumbar and femoral neck (p0.05. As a result, we suggest that systemic corticosteroids negatively affect bone mineral density more than inhaled corticosteroids in patients with COPD.

  19. Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database

    Science.gov (United States)

    Lee, Hyun; Rhee, Chin Kook; Lee, Byung-Jae; Choi, Dong-Chull; Kim, Jee-Ae; Kim, Sang Hyun; Jeong, Yoolwon; Kim, Tae-Hyung; Chon, Gyu Rak; Jung, Ki-Suck; Lee, Sang Haak; Price, David; Yoo, Kwang Ha; Park, Hye Yun

    2016-01-01

    Background Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD. Methods Patients with mild-to-moderate COPD (≥40 years) were extracted from Korean National Health and Nutrition Examination Survey data (2007–2012) and were linked to the national health insurance reimbursement database to obtain medical service utilization records. Results Of the 2,397 patients with mild-to-moderate COPD, 111 (4.6%) had severe exacerbations over the 6 years (0.012/person-year). Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only COPD patients (P<0.001). A multiple logistic regression presented that asthma was an independent risk factor of severe exacerbations in patients with mild-to-moderate COPD regardless of adjustment for all possible confounding factors (adjusted odds ratio, 1.67; 95% confidence interval, 1.002–2.77, P=0.049). In addition, age, female, poor lung function, use of inhalers, and low EuroQoL five dimensions questionnaire index values were independently associated with severe exacerbation in patients with mild-to-moderate COPD. Conclusion In this population-based study, the prevalence of severe exacerbations in patients with mild-to-moderate COPD was relatively low, compared with previous clinical interventional studies. Coexisting asthma significantly impacted the frequency of severe exacerbations in patients with mild-to-moderate COPD, suggesting application of an exacerbation preventive strategy in these patients. PMID:27143869

  20. Asthma in the Elderly

    Directory of Open Access Journals (Sweden)

    Domenico Lorenzo Urso

    2009-01-01

    Full Text Available Bronchial asthma is a common problem with enormous medical and economics impacts. It is an inflammatory disease of the airways associated with intermittent episodes of bronchospasm. Asthma is not uncommon in the elderly patients. Prevalence of asthma is similar in older and younger adults. Asthma in the elderly patient is underdiagnosed because of false perceptions by both patient and physician. The high incidence of comorbid conditions in the elderly patient makes the diagnosis and management more difficult. Correct diagnosis is demonstrated with spirometry. The goals of asthma treatment are to achieve and maintain control of symptoms and to prevent development of irreversible airflow limitation. Asthma drugs are preferably inhaled because this route minimizes systemic absorption and, thus, improves the ratio of the therapeutic benefit to the potential side-effects in elderly patients.

  1. Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease

    Institute of Scientific and Technical Information of China (English)

    Shan-Ping Jiang; Rui-Yun Liang; Zhi-Yong Zeng; Qi-Liang Liu; Yong-Kang Liang; Jian-Guo Li

    2003-01-01

    AIM: To investigate the effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease (GERD).MF THODS: Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B).Patients in group A (n=15) only received asthma medication including inhaled salbutamol 200 pg four times a day and budesonide 400 μg twice a day for 6 weeks. Patients in Group B (n=15) received the same medication as group A,and also antireflux therapy including oral omeprazole 20mg once a day and domperidone 10 mg three times a day for 6 weeks. Pulmonary function tests and histamine bronchoprovocation test were performed before and after the study.RESULTS: There was no significant difference in the baseline values of pulmonary function and histamine PC20-FEV1 between the two groups. At the end of the study, the mean values for VC, VC%, FVC, FVC%, FEV1, FEV1%, PEF, PEF%, PC20-FEV1were all significantly improved in group B, compared with group A.CONCLUSION: Antireflux therapy may improve pulmonary function and inhibit bronchial hyper-responsiveness in asthmatic patients with GERD.

  2. Border-line concentrations of SO/sub 2/ for patients with oversensitivity of the bronchial system

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M.S.; Ulmer, W.T. (Berufsgenossenschaftliche Krankenanstalten Bergmannsheil, Bochum (Germany, F.R.); Bochum Univ. (Germany, F.R.). Medizinische Klinik und Poliklinik)

    1979-01-01

    68 healthy persons and 81 patients with oversensitivity of the bronchial system were exposed against SO/sub 2/ with 7,5; 1 and 0,5 ppm. The acute exposure was performed twice with 0,5 and 1 ppm, once by inhalation via mouth and once by inhalation via nose. Control measurements were performed with physiolocical NaCl-aerosol-inhalation. We measured airway resistance and intrathoracic gas volume by bodyplethysmography. 0,5 ppm (approximately 1,35 mg/m/sup 3/) showed on the patients no stronger reactions as on the healthy persons. The reaction corresponded with the control experiments with physiological NaCl-aerosol-inhalation. 1 ppm (approximately 2,7 mg/m/sup 3/) SO/sub 2/ caused a high increase of airway resistance on 14 % of the patients. This effect was only seen by mouth breathing and not by breathing through the nose. 7 ppm caused by 40% of the patients a reaction outside of the normal variability. It is followed that the SO/sub 2/-concentration, now in our cities reached are not responsible for acute asthma attacks of our patients with oversensitivity of the bronchial system.

  3. [Reaction of population of pulmonary mast cells in rat bronchial asthma under the effect of β-adrenoreceptor antagonists].

    Science.gov (United States)

    Erokhina, I L; Voronchikhin, P A; Okovityĭ, S V; Emel'ianova, O I

    2013-01-01

    Multifunctional granular mast cells (MCs) are among targets in bronchial asthma (BA) therapy. We studied pulmonary MC population in a rat model of BA under the effect of β-adrenoreceptor antagonists and of the latter combined with the standard therapy (glucocorticoid budesonide + β2-adrenergic agonist salbutamol). MCs of different degrees of maturity were identified on paraffin section of lung stained with Alcian blue and Safranin. MC density in the lung of rats with BA increased 1.9 times. Alcian blue-positive immature cells predominated in the lungs of both intact rats and rats with BA. In response to pharmacological agents, the mean MC densities were reduced in 2-2.7 times in all the variants of experiments and were close to the norm. It allows us to suppose that MCs migration from the outside was suppressed and, in consequence of the decline of MC densities, the release of the mediators involved in the progression of BA may be diminished.

  4. Maximal expiratory flow-volume types in young subjects with past history of nasal allergy and bronchial asthma.

    Directory of Open Access Journals (Sweden)

    Meguro,Tadamichi

    1991-02-01

    Full Text Available Pulmonary function tests were performed on 252 healthy young subjects free from respiratory and allergic symptoms, and 80 young subjects with past history of nasal allergy (PNA and 10 subjects with past history of bronchial asthma (PBA. All the subjects were non-smokers. Maximal expiratory flow-volume (MEFV curves were visually classified into five types (A-E. The percent distribution of type A in healthy subjects was significantly higher than in the PNA group, while the total sum of percentage of types B, C, and D in the PNA group was significantly higher than in the healthy subjects. The percent distribution of type E in the PNA group was similar to that in the healthy subjects. The percent distribution of MEFV types were significantly different between healthy males and healthy females. The percent distribution of types A, B and E were the highest in healthy subjects, PNA and PBA groups, respectively. Conclusively, the difference in the percent distributions of MEFV types was recognized among healthy subjects, PNA and PBA groups.

  5. Individual-level socioeconomic status is associated with worse asthma morbidity in patients with asthma

    Directory of Open Access Journals (Sweden)

    Bouchard Anne

    2009-12-01

    Full Text Available Abstract Background Low socioeconomic status (SES has been linked to higher morbidity in patients with chronic diseases, but may be particularly relevant to asthma, as asthmatics of lower SES may have higher exposures to indoor (e.g., cockroaches, tobacco smoke and outdoor (e.g., urban pollution allergens, thus increasing risk for exacerbations. Methods This study assessed associations between adult SES (measured according to educational level and asthma morbidity, including asthma control; asthma-related emergency health service use; asthma self-efficacy, and asthma-related quality of life, in a Canadian cohort of 781 adult asthmatics. All patients underwent a sociodemographic and medical history interview and pulmonary function testing on the day of their asthma clinic visit, and completed a battery of questionnaires (Asthma Control Questionnaire, Asthma Quality of Life Questionnaire, and Asthma Self-Efficacy Scale. General Linear Models assessed associations between SES and each morbidity measure. Results Lower SES was associated with worse asthma control (F = 11.63, p Conclusions Results suggest that lower SES (measured according to education level, is associated with several indices of worse asthma morbidity, particularly worse asthma control, in adult asthmatics independent of disease severity. Results are consistent with previous studies linking lower SES to worse asthma in children, and add asthma to the list of chronic diseases affected by individual-level SES.

  6. High-resolution computed tomography findings in elderly patients with asthma

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, Sevda [Department of Radiology, School of Medicine, University of Kirikkale, 71100 Kirikkale (Turkey)]. E-mail: dryilmazsevda@yahoo.com; Ekici, Aydanur [Department of Pulmonary Medicine, School of Medicine, University of Kirikkale, 71100 Kirikkale (Turkey); Ekici, Mehmet [Department of Pulmonary Medicine, School of Medicine, University of Kirikkale, 71100 Kirikkale (Turkey); Keles, Hatice [Department of Internal Medicine, School of Medicine, University of Kirikkale, 71100 Kirikkale (Turkey)

    2006-08-15

    Objective: Based on the hypothesis that airway remodelling is related to the duration of asthma, HRCT scanning should show greater abnormalities in the early-onset than the late-onset asthmatics. It was, therefore, intended to assess the presence and the frequency of airway and parenchymal abnormalities with high-resolution computed tomography (HRCT) in elderly asthmatic patients, and to determine whether these abnormalities are related to the duration of asthma. Patients and methods: Sixty-eight clinically stable asthmatic patients aged {>=}60 yr were included in this prospective study. The patients were separated into two groups according to the duration of symptoms as late-onset asthma (n = 31) with disease duration of <5 yr, and early-onset asthma (n = 37) with disease duration of {>=}5 yr. All patients were lifelong non-smoker and had been using inhaled beta agonists and inhaled steroids. HRCT-scanning and histamine inhalation test were performed on all patients. Results: In comparison with late-onset asthmatic patients, those with early-onset asthma had significantly higher frequency of emphysema (21.6% versus 0.0%, p = 0.006), bronchial dilatation (13.9% versus 0.0%, p 0.03) and bronchial wall thickness (41.7% versus 12.9%, p = 0.01). Multiple logistic regression analysis identified that early-onset of disease was an independent risk factor for the presence of irreversible HRCT-scan abnormalities in elderly asthmatics [odds ratio (OR): 9.4 (2.7-32.7), p 0.00001]. Conclusion: Present data suggest that HRCT abnormalities in early-onset elderly asthmatics reflect parenchymal and airway changes that become irreversible throughout the long course of the disease.

  7. Application of controller medications on bronchial asthma during pregnancy%妊娠期支气管哮喘控制药物的应用

    Institute of Scientific and Technical Information of China (English)

    宋宁; 侯迎秋; 张聪敏

    2008-01-01

    应积极控制妊娠期支气管哮喘(简称哮喘)确保母婴健康;对不同级别的持续性哮喘可应用不同剂量吸人性激素控制(推荐布地奈德),当病情不能得到很好控制时,可根据药物妊娠危险性的分类标准和2004年美国哮喘教育和预防项目(NAEPP)妊娠哮喘防治指南选择其他药物;哮喘控制药物妊娠期应用的安全性和有效性仍需进一步评价.%Bronchial asthma(asthma)should be controlled during pregnancy to ensure maternal and infant health.Different dosages of inhaled corticosteroid(preferably budesonide)are recommended for different levels of persistent asthma,and when illness can not be well controlled,other asthma controller medications should be selected according to the US Food and Drug Administration(FDA)pregnancy category ratings and the 2004 updated recommendations from the national asthma education and prevention program (NAEPP).The safety and effectiveness of many asthma controller medications during pregnancy are still uncertain and need further investigation.

  8. Asthma

    OpenAIRE

    Kim, Harold; Mazza, Jorge

    2011-01-01

    Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA) inhalers are pr...

  9. Asthma

    OpenAIRE

    Kim Harold; Mazza Jorge

    2011-01-01

    Abstract Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs) represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA) inhale...

  10. “Peripheral Neuropathy Crippling Bronchial Asthma”: Two Rare Case Reports of Churg-Strauss Syndrome

    Directory of Open Access Journals (Sweden)

    Kamal Kishore Pandita

    2014-01-01

    Full Text Available Churg-Strauss syndrome (CSS is a rare cause of vasculitic neuropathy. Although rare and potentially fatal, Churg-Strauss syndrome (CSS is easily diagnosable and treatable. The presence of bronchial asthma with peripheral neuropathy in a patient alerts a physician to this diagnosis. This is vividly illustrated by the presented two cases who had neuropathy associated with bronchial asthma, eosinophilia, sinusitis, and positive perinuclear antineutrophil cytoplasmic antibodies (p-ANCA test, which improved with administration of steroids.

  11. Adjusting prednisone using blood eosinophils reduces exacerbations and improves asthma control in difficult patients with asthma.

    Science.gov (United States)

    Wark, Peter Ab; McDonald, Vanessa M; Gibson, Peter G

    2015-11-01

    Severe or therapy-resistant asthma represents a major problem, and despite advanced treatment, many patients require oral corticosteroids (OCS). We aimed to determine if patients with severe asthma and elevated peripheral blood eosinophils (PBE) could have treatment with OCS adjusted using an algorithm that controlled PBE (asthma symptoms with an overall lower OCS dose.

  12. Specific regulator of eosinophil apoptosis: Siglec-8-new hope for bronchial asthma treatment

    Institute of Scientific and Technical Information of China (English)

    FENG Yin-he; MAO Hui

    2012-01-01

    Objective It is known that Siglec-8 is selectively expressed on human eosinophils at a high level and mediates eosinophil apoptosis when crosslinked with its antibody.The aim of our review is to elucidate the molecular and biological characteristic of Siglec-8 and then discuss the function and possible mechanisms of Siglec-8 in eosinophils.Thereby,we will expand our understanding to the regulation of eosinophil apoptosis,and provide important clues to the treatment of asthma and other hyper-eosinophilic diseases.Data sources Most articles were identified by searching of PubMed online resources using the key term Siglecs.Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators in the field were selected.Results Siglec-8 is selectively expressed on human eosinophil and can specifically induce eosinophil apoptosis.Conclusion The restricted expression of Siglec-8 on human eosinophil and the rapid progress in understanding its role as cell signaling and activation of death receptors have made it an attractive target for treatment of asthma and other hyper-eosinophilic diseases.

  13. Zoneterapi og asthma

    DEFF Research Database (Denmark)

    Brygge, Thor; Heinig, John Hilligsøe; Collins, Philippa

    2002-01-01

    INTRODUCTION: Many patients with asthma seek alternative or adjunctive therapies. One such modality is reflexology. Our aim was to examine the popular claim that reflexology treatment benefits bronchial asthma. MATERIAL AND METHODS: Ten weeks of either active or simulated (placebo) reflexology were...... compared in an otherwise blind, controlled trial of 40 patients with asthma. RESULTS: Objective lung function tests did not change. Subjective scores and bronchial sensitivity to histamine improved on both regimens, but no differences were found in the groups receiving active or placebo reflexology....... However, a trend in favour of reflexology became significant when a supplementary analysis of symptom diaries was carried out. At the same time a significant pattern compatible with subconscious un-blinding was found. DISCUSSION: We found no evidence that reflexology has a specific effect on asthma beyond...

  14. Validity of Asthma Control Test in Chinese patients

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xin; LI Jing; WANG Chang-zheng; DING Feng-ming; LIN Jiang-tao; YIN Kai-sheng; CHEN Ping; HE Quan-ying; SHEN Hua-hao; WAN Huan-ying; LIU Chun-tao

    2007-01-01

    Background So far, in China, there has been no effective or easy procedure to define the control of asthma. This study assesses the validity of Asthma Control Test in Chinese patients.Methods Three questionnaires (Asthma Control Test, Asthma Control Questionnaire and the 30 second asthma test)were administered to 305 asthma patients from 10 teaching hospitals across China. Spirometry was also used. Asthma specialists rated the control of asthma according to patients' symptoms, medications and forced expiratory volume in first second. The patients were divided into noncontrolled group and controlled group according to the specialists' rating.Reliability, empirical validity and screening accuracy were conducted for Asthma Control Test scores. Screening accuracy was compared among 3 questionnaires. The patients' self rating and the specialists' rating were also compared.Results The internal consistency reliability of the 5-item Asthma Control Test was 0.854. The correlation coefficient between Asthma Control Test and the specialists' rating was 0.729, which was higher than other instruments. Asthma Control Test scores discriminated between groups of patients differing in the percent predicted forced expiratory volume in first second (F=26.06, P<0.0001), the specialists' rating of asthma control (F=88.24, P<0.0001) and the Asthma Control Questionnaire scores (F=250.57, P<0.0001). Asthma Control Test showed no significant difference with Asthma Control Questionnaire in the percent correctly classified, while the percent correctly classified by Asthma Control Test was much higher than 30 second asthma test. The patients' self rating was the same as assessment of the specialists (t=0.65, P=0.516).Conclusion The Asthma Control Test is an effective and practicable method for assessing asthma control in China.

  15. [Latent tetany masked by syndroms of bronchial asthma and depressive syndrome. Case report].

    Science.gov (United States)

    Wajda, Beata; Drozdowska, Adrianna; Kuziemski, Krzysztof; Górska, Lucyna; Lewandowska, Katarzyna; Jassem, Ewa

    2006-01-01

    Tetany, which occurs in young women, poses common diagnostic problem. Two types of tetany are distinguished: one which is characterized by hypocalcemia and which rarely occurs (in person after strumectomy in the course of post-operational hypoparathyroidism) and latent one, which occurs more often. In the literature there is a lack of precise data concerned witch most probably results from its underestimation. Clinical symptoms which appear in latent tetany (normocalcemic) are related to the intracellular magnesium deficiency and increased respiratory drive. A noncharacteristic clinical picture and the lack of a pathognomonic symptom, cause that despite of the fearly common occurrence, the latent tetany is rarely recognized. In this paper the case of a 53 year old women has been described. The women had the symptoms of gastroesophageal reflux of asthma and depressive syndrome, witch masked the symptoms of the latent tetany.

  16. Investigation and analysis of related factors of non-conformal drugs used in bronchial asthma patients%支气管哮喘患者非正规来源药物使用状况调查及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    魏春华; 温明春; 席素婷; 胡兆秋; 刘艳红; 于农; 李强; 韩晶

    2011-01-01

    Objective To investigate the sources, transmission and use of non-conformal bronchial asthma (asthma) drugs, analyze the related factors of the causes and existences, and put forward some suggestions to restrain the use of these drugs. Methods Patients treated in Weifang Asthma Hospital from May 2008 to April 2010 were investigated about their sources of non-formal drugs, history of accepting standard treatment, termination reasons and so on by the questionnaire interview. The xamination items on these patients included plasmatic cortisol (COR), bone mineral density (BMD) , and composition of the drugs by high pressure liquid chromatograph (HPLC) and MR spectroscopy (MRS). Results ①The situations of patients treated with non-formal drugs: 1 044 patients have accepted nonformal asthma drugs, making up 29. 19% of total inpatients in the orresponding period, while the oldest patients were 78 years old and the youngest were 6 years old. Most of these patients were rural residents (56.70%), low education level (primary educational and lower were 38.60%), no income and lowincome (accounting for 71. 45%). ②Status of non-formal drugs:the non-formal drug came from different regions of China, but predominantly from Henan province (accounting for 70.01%), and then Hebei province, Shandong province, Beijing, and Shanxi province etc. Drugs were bought by mail or in country clinics and country markeplaces, and the news were got from other patients, some country doctors or the advertising. Most of the drug were made into capsule, and the name were related to the function which were marked "Pure Chinese Medicine" or "Home Remedy " and so on. Reference Numbe:some of the drugs had fake qualifies for health-tax credit and non marked. These drugs were different in price, with the lowest medicine fee 18 yuan every month, and most of them were less than 100 yuan every month (accounting for 78.1%), but some individual drugs were expensive and attained thousands yuan per package

  17. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma

    Science.gov (United States)

    Bartel, Sabine; Schulz, Nikola; Alessandrini, Francesca; Schamberger, Andrea C.; Pagel, Philipp; Theis, Fabian J.; Milger, Katrin; Noessner, Elfriede; Stick, Stephen M.; Kicic, Anthony; Eickelberg, Oliver; Freishtat, Robert J.; Krauss-Etschmann, Susanne

    2017-01-01

    Asthma is highly prevalent, but current therapies cannot influence the chronic course of the disease. It is thus important to understand underlying early molecular events. In this study, we aimed to use microRNAs (miRNAs) - which are critical regulators of signaling cascades - to identify so far uncharacterized asthma pathogenesis pathways. Therefore, deregulation of miRNAs was assessed in whole lungs from mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI). In silico predicted target genes were confirmed in reporter assays and in house-dust-mite (HDM) induced AAI and primary human bronchial epithelial cells (NHBE) cultured at the air-liquid interface. We identified and validated the transcription factor cAMP-responsive element binding protein (Creb1) and its transcriptional co-activators (Crtc1-3) as targets of miR-17, miR-144, and miR-21. Sec14-like 3 (Sec14l3) - a putative target of Creb1 - was down-regulated in both asthma models and in NHBE cells upon IL13 treatment, while it’s expression correlated with ciliated cell development and decreased along with increasing goblet cell metaplasia. Finally, we propose that Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli. This study shows that miRNA profiles can be used to identify novel targets that would be overlooked in mRNA based strategies. PMID:28383034

  18. 骨膜蛋白在支气管哮喘中的研究进展%New Research Development of Periostion in Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    石惠玲(综述); 芦爱萍(审校)

    2015-01-01

    骨膜蛋白,一种细胞外基质蛋白,属于成束蛋白家族,已经被报道在组织器官发育或修复的重构过程中起重要作用,慢性呼吸道炎症和气道重构是支气管哮喘的显著特征。研究发现,骨膜蛋白是白细胞介素(IL)4和IL-13的下游蛋白,IL-4和IL-13是Th2型免疫反应的特征细胞因子,骨膜蛋白是支气管哮喘的上皮下纤维化的组成部分,在过敏性哮喘的激活和维持阶段起重要作用。%Periostin,an extracellular matrix protein belonging to the fasciclin family,has been reported to play a critical role in the process of remodeling during tissue and organ development or repair. Chronic airway inflammation and airway remodeling is the typical feature of bronchial asthma. Studies found that periostin is a downstream molecule of interleukin IL-4 and IL-13,signature cytokines of Th2 immune responses,a compo-nent of subepithelial fibrosis in bronchial asthma,playing a critical role in the activation and maintenance of allergic asthma.

  19. 临床护理路径在老年支气管哮喘护理中的应用%Application of clinical nursing pathway in nursing care of bronchial asthma in the elderly

    Institute of Scientific and Technical Information of China (English)

    余晶晶

    2015-01-01

    Objective:To investigate the effect of the application of clinical nursing path in bronchial asthma in the elderly. Methods:84 cases of senile patients with bronchial asthma were randomly divided into two groups.The observation group were given the clinical nursing pathway,while the control group were given traditional nursing mode.We compared the nursing effect of the two groups patients.Results:The patients' satisfaction with nursing care of the observation group was significantly higher than that of the control group;the disease cognition,health knowledge,skill mastery,compliance of the observation group were significantly better than those of the control group,and with the statistical difference(P<0.05).Conclusion:The implementation of clinical nursing pathway in patients with bronchial asthma in the elderly can improve the life quality of the patients,and the nursing satisfaction is high.%目的:探讨临床护理路径在老年支气管哮喘中的应用效果。方法:将84例老年支气管哮喘患者随机分为两组,观察组实施临床护理路径,对照组采用传统护理模式。比较两组患者护理效果。结果:观察组护理满意度显著高于对照组;在疾病认知、健康知识掌握、相关技能掌握、遵医行为上,观察组均显著优于对照组,差异具有统计学意义(P<0.05)。结论:对老年支气管哮喘患者实施临床护理路径,可提高患者生活质量,护理满意度高。

  20. Relación entre la severidad de las manifestaciones de asma bronquial y el cumplimiento del tratamiento intercrisis Relation between the severity of bronchial asthma manifestations and the fulfilment of the inter-crisis treatment

    Directory of Open Access Journals (Sweden)

    Tatiana de la Vega Pazitková

    2011-09-01

    Full Text Available INTRODUCCIÓN: En la última década han aumentado la morbilidad y la mortalidad por asma bronquial. Se estima que esta enfermedad la padecen actualmente 300 millones de personas en el mundo. En Cuba, el asma bronquial constituye también un importante problema de salud. OBJETIVO: Establecer la relación entre el cumplimiento del tratamiento en periodos intercrisis y la severidad de las manifestaciones clínicas de la enfermedad. MÉTODOS: Se estudiaron 119 pacientes con diagnóstico de asma bronquial pertenecientes al policlínico "Ana Betancourt". Para la recolección de datos se aplicaron cuestionarios de forma individual a los pacientes o a los familiares que están directamente al cuidado de estos. Los pacientes fueron agrupados según la Guía española para el manejo del asma de 2009. RESULTADOS: Se detectaron 23 pacientes asmáticos intermitentes, 42 persistentes leves, 36 persistentes moderados y 18 persistentes graves. El 95 % de los pacientes estudiados desencadenaba la crisis con inhalantes respiratorios. En el 79 % de los hogares se detectó la presencia de fumadores. Solo el 41 % de los pacientes cumplía el tratamiento correctamente en los periodos intercrisis. CONCLUSIONES: Existe una relación directa entre la severidad de las manifestaciones clínicas del asma bronquial y el no cumplimiento del tratamiento intercrisis, lo que puede condicionar la exacerbación de la enfermedad.INTRODUCTION: In past decade the morbidity and mortality from bronchial asthma have increased. This is a diseased suffered nowadays by 300 millions of persons in the world. In Cuba, the bronchial asthma is also an important health problem. OBJECTIVE: To establish the relation between the fulfilment of treatment in inter-crisis period and the severity of the clinical manifestations of this entity. METHODS: A total of 119 patients diagnosed with bronchial asthma from the "Ana Betancourt" Polyclinic were studied. In data collection authors applied individual

  1. 支气管哮喘动物模型的研究进展%Research Progress in Animal Model of Bronchial Asthma

    Institute of Scientific and Technical Information of China (English)

    吕洪臻; 黄诚

    2012-01-01

    建立支气管哮喘动物模型有助于对哮喘的研究.针对Th2型细胞驱动的变态反应动物模型研究较多,并已应用于相关药物的研究.对支气管哮喘动物模型有一定疗效的药物对人类患者疗效欠佳,这可能与选择实验的动物和诱导哮喘表型的方法有关.啮齿动物和豚鼠模型是最常使用的支气管哮喘动物模型.目前动物模型仍存在许多问题,如在免疫学和解剖学上动物与人类存在差异,大多数模型在致敏时需要佐剂,成年动物应用较多.因此,明确每种模型的相对优点和局限性十分必要.%Animal models of bronchial asthma are beneficial to the study of asthma. These models have highlighted the importance of T-helper type 2 driven allergic responses in the progression of asthma and have been useful in the identification of interrelated drugs. Many drugs that have been shown to have some efficacy in animal models of bronchial asthma have shown little clinical benefit in human asthmatics, which may be due to a number of factors including the species of animal chosen and the methods used to induce an asthmatic phenotype in animals. Rodents and guinea-pigs are the most popular bronchial asthma models. At present, there are a lot of problems in animal models of asthma, for example the difference in immunology and anatomy between these species and human, the requirement for adjuvant during sensitization in most models, adult animals as the primary disease model. Therefore understanding of the relative merits and limitations of each model is necessary.

  2. [Guidelines for the diagnosis and management of bronchial asthma--a comparison of the Japanese guidelines for the adult asthma with GINA and ICR].

    Science.gov (United States)

    Kabe, J

    1996-11-01

    Although the concept of asthma management of the Japanese Guidelines is basically similar in the other guidelines including GINA, ICR, of British Thoracic Society, and of the other countries, assuming that asthma is a chronic inflammatory disorder of the airway, the program of stepwise pharmacologic therapy is not the same in various points. Therapy suggested in the Japanese Guidelines is different in 1) oral antiallergic drugs are widely used, 2) patients prefer oral bronchodilators to inhaled bronchodilators, 3) sustained released theophylline in the long term management and intravenous infusion of aminophylline for the treatment of acute exacerbation are accepted and frequently used by the physicians. Also the differences in the choice of medication between GINA, which is characterized by concept of cost, and other guidelines are discussed.

  3. 青岛市儿童支气管哮喘合并变应性鼻炎问卷调查分析%CHILDREN WITH BRONCHIAL ASTHMA COMPLICATED WITH ALLERGIC RHINITIS IN QINGDAO: A QUESTIONNAIRE INVESTIGATION AND ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    许美; 林荣军; 刘莹莹; 路玲

    2012-01-01

    目的 了解青岛市儿童支气管哮喘合并变应性鼻炎的情况及二者关系.方法 随机抽取2010年5月-2011年10月在我院儿科门诊确诊的年龄≤14岁哮喘病儿372例,其中单纯哮喘232例(Ⅰ组),哮喘合并变应性鼻炎140例(Ⅱ组),选取非呼吸道疾病儿童372例作为对照组(Ⅲ组).通过家长笔答问卷,调查病儿一般情况、伴发疾病、家族史、个人过敏史、治疗情况等.结果 Ⅰ、Ⅱ组有家族及个人药物过敏史者明显多于Ⅲ组(x2=47.11~149.73,P<0.05),Ⅱ组有皮肤过敏史者明显多于Ⅰ组(x2=8.50,P<0.05).哮喘合并变应性鼻炎病儿中有63例(45.0%)先发生变应性鼻炎,55例(39.3%)先发生支气管哮喘.72.1%的哮喘合并变应性鼻炎病儿接受了鼻炎治疗,以单用或联合使用抗组胺药物和使用鼻用糖皮质激素为主要治疗措施.结论 支气管哮喘和变应性鼻炎是同一种疾病在不同部位的表现,两者有一定关联性,积极联合防治,可以提高治疗效果.%Objective To investigate the condition of children suffering from bronchial asthma complicated with allergic rhinitis in Qingdao and the relationship between the two conditions. Methods A random sampling of 372 asthma patients, aged ≤14 years old, confirmed in out-patient department of our hospital, from May 2010 to October 2011 , were divided into simple asthma group (Group 1,232 cases) , bronchial asthma complicated with allergic rhinitis group (Group 2,140 cases) , and 372 children with non-respiratory tract diseases (Group 3) served as controls. A questionnaire was used to survey their parents on genera! condition, concomitant diseases history of allergy, and treatment. Results The history of allergy of individuals and family members were more recorded in groups 1 and 2 than in group 3 (x2=47. 11 — 149. 73,P<0. 05). In group 2, the history of skin allergy was more than that in group 1 (x2 — 8. 50 , P<0. 05). Of the patients with combined

  4. Role of Lyn kinase and endoplasmic reticulum stress in allergic bronchial asthma%Lyn激酶和内质网应激在过敏性支气管哮喘中的作用

    Institute of Scientific and Technical Information of China (English)

    伍娟; 杨小琼

    2016-01-01

    Bronchial asthma is an airway inflammatory disease which many kinds of cells and cellular compo-nents are involved in. It is characterized by airway inflammation, airway remodeling and airway hyperresponsiveness. However, the pathogenesis of bronchial asthma is very complex. Therefore in this paper, the important roles of Lyn ki-nase and endoplasmic reticulum stress in the pathogenesis of bronchial asthma are reviewed.%支气管哮喘是多种细胞及细胞组分参与的气道炎症性疾病,主要以气道炎症和气道重塑、气道高反应性为特征;然而其发病机制十分复杂,本文对Lyn激酶和内质网应激在支气管哮喘的发病机制中的重要作用进行综述.

  5. Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.

    Directory of Open Access Journals (Sweden)

    Tatsuya Nagano

    Full Text Available BACKGROUND: Phospholipase Cε (PLCε is an effector of Ras and Rap small GTPases and expressed in non-immune cells. It is well established that PLCε plays an important role in skin inflammation, such as that elicited by phorbol ester painting or ultraviolet irradiation and contact dermatitis that is mediated by T helper (Th 1 cells, through upregulating inflammatory cytokine production by keratinocytes and dermal fibroblasts. However, little is known about whether PLCε is involved in regulation of inflammation in the respiratory system, such as Th2-cells-mediated allergic asthma. METHODS: We prepared a mouse model of allergic asthma using PLCε+/+ mice and PLCεΔX/ΔX mutant mice in which PLCε was catalytically-inactive. Mice with different PLCε genotypes were immunized with ovalbumin (OVA followed by the challenge with an OVA-containing aerosol to induce asthmatic response, which was assessed by analyzing airway hyper-responsiveness, bronchoalveolar lavage fluids, inflammatory cytokine levels, and OVA-specific immunoglobulin (Ig levels. Effects of PLCε genotype on cytokine production were also examined with primary-cultured bronchial epithelial cells. RESULTS: After OVA challenge, the OVA-immunized PLCεΔX/ΔX mice exhibited substantially attenuated airway hyper-responsiveness and broncial inflammation, which were accompanied by reduced Th2 cytokine content in the bronchoalveolar lavage fluids. In contrast, the serum levels of OVA-specific IgGs and IgE were not affected by the PLCε genotype, suggesting that sensitization was PLCε-independent. In the challenged mice, PLCε deficiency reduced proinflammatory cytokine production in the bronchial epithelial cells. Primary-cultured bronchial epithelial cells prepared from PLCεΔX/ΔX mice showed attenuated pro-inflammatory cytokine production when stimulated with tumor necrosis factor-α, suggesting that reduced cytokine production in PLCεΔX/ΔX mice was due to cell-autonomous effect of

  6. Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.

    Science.gov (United States)

    Nagano, Tatsuya; Edamatsu, Hironori; Kobayashi, Kazuyuki; Takenaka, Nobuyuki; Yamamoto, Masatsugu; Sasaki, Naoto; Nishimura, Yoshihiro; Kataoka, Tohru

    2014-01-01

    Phospholipase Cε (PLCε) is an effector of Ras and Rap small GTPases and expressed in non-immune cells. It is well established that PLCε plays an important role in skin inflammation, such as that elicited by phorbol ester painting or ultraviolet irradiation and contact dermatitis that is mediated by T helper (Th) 1 cells, through upregulating inflammatory cytokine production by keratinocytes and dermal fibroblasts. However, little is known about whether PLCε is involved in regulation of inflammation in the respiratory system, such as Th2-cells-mediated allergic asthma. We prepared a mouse model of allergic asthma using PLCε+/+ mice and PLCεΔX/ΔX mutant mice in which PLCε was catalytically-inactive. Mice with different PLCε genotypes were immunized with ovalbumin (OVA) followed by the challenge with an OVA-containing aerosol to induce asthmatic response, which was assessed by analyzing airway hyper-responsiveness, bronchoalveolar lavage fluids, inflammatory cytokine levels, and OVA-specific immunoglobulin (Ig) levels. Effects of PLCε genotype on cytokine production were also examined with primary-cultured bronchial epithelial cells. After OVA challenge, the OVA-immunized PLCεΔX/ΔX mice exhibited substantially attenuated airway hyper-responsiveness and broncial inflammation, which were accompanied by reduced Th2 cytokine content in the bronchoalveolar lavage fluids. In contrast, the serum levels of OVA-specific IgGs and IgE were not affected by the PLCε genotype, suggesting that sensitization was PLCε-independent. In the challenged mice, PLCε deficiency reduced proinflammatory cytokine production in the bronchial epithelial cells. Primary-cultured bronchial epithelial cells prepared from PLCεΔX/ΔX mice showed attenuated pro-inflammatory cytokine production when stimulated with tumor necrosis factor-α, suggesting that reduced cytokine production in PLCεΔX/ΔX mice was due to cell-autonomous effect of PLCε deficiency. PLCε plays an important

  7. 止喘汤减少糖皮质激素吸入量治疗支气管哮喘的临床研究%Zhichuan decoction with glucocorticoid in treatment of bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    王庆; 李一; 霍博雅; 郭汉卿; 寇伟莉

    2008-01-01

    Three hundred and ninety five patients with bronchial asthma were randomly divided into 4 groups:patients in group A received inhaled beclomethasone dipropionate(BDP)100μg and Zhichuan decoction;patients in group B were given inhaled BDP 200μg;patients in group C took Zhichuan decoction only;patients in group D were given inhaled BDP 100 μg.Methacholine airway reactivity,pulmonary ventilation function,serum acidophilia cationic protein and symptom score were determined before and after treatment.All above indicators were significantly improved in groups A and B,which suggests that Zhichuan decoction could reduce hormone dosage in control of airway chronic inflammation,reduction of airway reactivity and improvement of pulmonary ventilation function of patients with bronchial asthma.%将395例哮喘患者随机分为4组,A组在吸入二丙酸倍氯米松100μg的同时服用止喘汤,B、C、D组分别单纯吸入二丙酸倍氯米松200μg、服用止喘汤、吸入二丙酸倍氯米松100μg.A、B组患者治疗前后乙酰甲胆碱气道反应性、肺通气功能、血清嗜酸性阳离子蛋白及症状积分均有明显改善.提示止喘汤在减少糖皮质激素吸入量的同时能控制气道慢性炎症、降低气道反应性、提高患者肺通气功能.

  8. Bronchial asthma: correlation of high resolution computerized tomography findings with clinical data; Asma bronquica: correlacao de achados em tomografia computadorizada de alta resolucao com dados clinicos

    Energy Technology Data Exchange (ETDEWEB)

    Mogami, Roberto [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Servico de Radiologia; Marchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia; Kirk, Kennedy; Capone, Domenico [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Servico de Pneumologia; Daltro, Pedro [Instituto Fernandes Figueira, Rio de Janeiro, RJ (Brazil). Servico de Radiologia

    1999-04-01

    In this work we did a sectional study of 31 asthmatic patients with several levels of disease severity, which were submitted to high resolution computed tomography of the thorax and spirometry, between the months of July, 1995 and August, 1997. The tomographic findings were correlated with the clinical classification of the patients and the most frequent tomographic findings were bronchial wall thickening, bronchial dilatation, air trapping, centrilobular opacities, cicatricial linear shadows, mucoid impaction, emphysema and atelectasis. In asthmatic patients of long duration we observed small airway disease and irreversible lesions as the predominant findings. In smoking patients there was no high frequency of emphysema. (author)

  9. Allergies, asthma, and dust

    Science.gov (United States)

    Reactive airway disease - dust; Bronchial asthma - dust; Triggers - dust ... Things that make allergies or asthma worse are called triggers. Dust is a common trigger. When your asthma or allergies become worse due to dust, you are ...

  10. Allergies, asthma, and molds

    Science.gov (United States)

    Reactive airway - mold; Bronchial asthma - mold; Triggers - mold; Allergic rhinitis - pollen ... Things that make allergies or asthma worse are called triggers. Mold is a common trigger. When your asthma or allergies become worse due to mold, you are ...

  11. Persistent Airflow Obstruction in Young Adult Asthma Patients

    Directory of Open Access Journals (Sweden)

    Kiyoshi Sekiya

    2012-01-01

    Conclusions: In this study, patients not undergoing treatment for asthma were examined. History of childhood asthma and smoking history may be the risk factors for persistent airway obstruction in the asthma patients with mild subjective symptoms. Tests on the bronchodilator change in FEV1 should be performed in patients with history of childhood asthma and smoking history, even if they have only mild subjective symptoms.

  12. HLA-DRB GENES POLYMORPHISM IN CHINESE NORTHERN PATIENTS WITH ATOPIC ASTHMA

    Institute of Scientific and Technical Information of China (English)

    高金明; 林耀广; 邱长春; 马毅

    1998-01-01

    Objective. Atopie asthma provides a usetul model for evaluating the genetic tactors that control human immune responsiveness. HLA class Ⅱ gene products are involved in the control of immune response. As HLA-DRB gene is the most polymorphic HLA class Ⅱ gene, we investigated whether susceptibility or resistance to the disease is associated with HLA-DRB. Methods. Blood samples were obtained from two groups of unrelated Chinese northern adults: (1) 50 atopic asthma (7 of them with familial aggregation) ; (2) 80 healthy controls without asthma or atopy and other HLA-associated diseases. Genomic DNA was extracted from peripheral venous blood leucocytes. The polymorphie second exon of HLA-DRB gene was amplified by sequence-specific primer polymerase chain reaction (SSP/PCR) methods. All patients had their serum IgE(total and spscifie) antibody levels by RAST, bronchial reactivity assessed by methaeholine brocho-provocation test and/or hronchodilation test. Results.There was an increased gene frequency of DR52 and DR52 in asthmatic subjects compared with healthy subjects(17% vs 4.3%, P<0. 01% 50% vs 17.5%, P<0. 01), and the decreased frequency of DR2(15) and DR52 in asthmatic patients(7% vs 18%, P<0. 05; 2% vs 33%, P<0. 01). We found the positive association between DR5(13)-DR52 and sIgE antibody responsiveness to d1 (from house dust mite allergen ); negative association between HLA-DRB alleles and TIgE or BHR ( bronchial hyperresponsiveness). Conclusion. The results suggested that HLA haplotype DR6(13)-DR52 was significantly implicated in suseeptibility to house dust mite induced-asthma, at least it would he more closely assocaated with atopic asthms. Conversely, alleles DR2(15) and DR51 might corder protection against the disease. HLA-DRB genes were particularly involved in regulating human atopie immune response in asthma.

  13. Tissue fibrocytes in patients with mild asthma: A possible link to thickness of reticular basement membrane?

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    Bjermer Leif

    2006-03-01

    Full Text Available Abstract Background Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveolar lavage fluid (BALF in steroid-naive patients with mild asthma and controls. Methods Patients with mild asthma (n = 9 were recruited and divided into two categories based on whether or not fibroblast-like cells could be established from BALF. Non-asthmatic healthy subjects (n = 5 were used as controls. Colocalization of the fibrocyte markers CD34, CD45RO, procollagen I, and α-smooth muscle actin (α-SMA were identified in bronchial biopsies from patients and controls by confocal microscopy. Kruskall-Wallis method was used to calculate statistical significance and Spearman coefficient of rank correlation was used to assess the degree of association. Results In patients with BALF fibroblasts, a 14-fold increase of tissue cells expressing CD34/CD45RO/α-SMA and a 16-fold increase of tissue cells expressing CD34/procollagen I was observed when compared to controls (p Conclusion These findings indicate a correlation between recruited fibrocytes in tissue and thickness of basement membrane. Fibroblast progenitor cells may therefore be important in airway remodeling in steroid-naive patients with mild asthma.

  14. Bronchial histamine challenge in the diagnosis of asthma. The predictive value of changes in airway resistance determined by the interrupter method

    DEFF Research Database (Denmark)

    Madsen, F; Holstein-Rathlou, N H; Frølund, L

    1986-01-01

    to variation in peak expiratory flow rate and medical history. Response to challenge was determined by the interrupter method, and the concentration of histamine inducing a 40% increase in resistance to breathing (PC40-Rt) was calculated from the log dose response curve. When defining a positive test as a test....../ml the predictive value of a negative test in the diagnosis of asthma was increased to 0.81. The interrupter technique is suitable for diagnostic purposes in the detection and exclusion of bronchial asthma....... giving PC40-Rt-values below 2.00 mg/ml, the predictive value of a positive test was 0.75 and the predictive value of a negative test was 0.72. By decreasing the limit for a positive test to 0.25 mg/ml the corresponding predictive value was increased to 0.91. When further increasing the limit to 4.00 mg...

  15. Changes of serum soluble intercellular adhesion molecule-1 in children patients with bronchial asthma by Pediatric Cough and Asthma Relieving Gel%小儿止咳平喘露的平喘作用及其对外周血可溶性细胞黏附分子-1的影响

    Institute of Scientific and Technical Information of China (English)

    宋慧珠

    2013-01-01

    Objective To investigate the antiasthmatic effect of Pediatric Cough and Asthma Relieving Gel and its effect on peripheral blood soluble cell adhesion molecule-1. Methods 236 children with cough and asthma were selected in the hospital from October 2010 to March 2012,who were divided into two groups randomly. 118 children used cough syrup in the treatment as the control group. 118 children used Pediatric Cough and Asthma Relieving Gel in the treatment as the observation group. All children underwent observation of cough induced by histamine,observation of cough induced by citric acid,sputum eosinophil cells count,detection of peripheral blood soluble cell adhesion molecule-1. Clinical indexes were compared between two groups. Results Cough latency induced by histamine in the observation group [(81.4±16.5)s] was significantly longer than that in the control group [(52.7±12.0)s]. Cough latency induced by citric acid in the observation group [(48.3±12.6)s] was significantly longer than that in the control group [(30.1±9.2)s]. Sputum eosinophil cells count in the observation group [(1.3±0.6)x106/mL] was significantly lower than that in the control group [(2.1±1.0)×106/mL]. Peripheral blood soluble cell adhesion molecule-1 in the observation group [(42.7±13.8)μg/L] was significantly lower than that in the control group [(59.2±17.5) μg/L]. The difference was statistically significant (P < 0.05). Conclusion Pediatric Cough and Asthma Relieving Gel can obvious relieve cough and asthma,which not only can reduce the induced sputum in children with eosinophilic,but also can effectively reduce level of peripheral blood soluble cell adhesion molecule-1 of children.%目的 探讨小儿止咳平喘露的平喘作用及其对外周血可溶性细胞黏附分子-1的影响.方法选取本院2010年10月~2012年3月收治的咳喘患儿236例,随机分为两组,采用小儿止咳糖浆治疗患儿118例为对照组,采用小儿止咳平喘露治疗患儿118例为观察

  16. 150例小儿过敏性支气管哮喘发病因素分析%Analysis of 150 cases of Chidren allergic bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    杨丽萍

    2016-01-01

    Objective To investigate the relative factors of the incidence of allergic bronchial asthma in children with 150 cases of allergic bronchial asthma. Methods A total of 150 cases of allergic bronchial asthma children as the object of study in the observation group, February 2015 to 2016 February by the hospital treatment of children, in addition to select February 2015 to 2016 February by the hospital treatment of 150 cases of non allergic bronchial asthma children as the research object in the control group, by the self-made questionnaire on the incidence of the two groups of children related infection factors, immune factors, environmental factors and other factors were analyzed. Results an observation group and a control group of children with recurrent respiratory tract infection history, food allergy, drug allergy, paint, a history of exposure to fumes, 2 years old in passive smoking history, family history of asthma, history of pet keeping, breastfeeding history data and control group compared the difference, with significant. Conclusion There are many factors of allergic bronchial asthma should be early prevention, early detection and early treatment, to reduce the incidence of the disease and promote the health of children and growth. The research in clinical has significant value.%目的:通过对150例过敏性支气管哮喘的患儿进行调查研究,探究与小儿过敏性支气管哮喘发病的相关因素。方法选取150例过敏性支气管哮喘患儿作为本次的研究对象中的观察组,均为2015年2月-2016年2月经由该院治疗的患儿,另外选取2015年2月-2016年2月经由该院治疗的150例非过敏性支气管哮喘患儿作为该次研究对象中的对照组,通过该院自制的调查问卷对两组患儿发病有关的感染因素、免疫因素、环境因素与其他因素进行分析。结果观察组与对照组患儿的反复呼吸道感染史、食物过敏、药物过敏、油漆、油烟接触史,2岁内被动

  17. Analysis of the Pathogenic Factors of Bronchial Asthma and the Corresponding Treatment Measures%分析支气管哮喘的致病因素以及相应处理措施

    Institute of Scientific and Technical Information of China (English)

    张秋菊

    2016-01-01

    目的:探讨分析支气管哮喘的致病因素以及相应处理措施。方法:从2013年5月至2015年7月期间我院接收治疗的支气管哮喘患者中随机选取56例作为本研究病例对象,将此56例患者划分为研究组,再选取同时期来我院体检健康者56例作为对照组,回顾分析两组对象临床资料,总结支气管哮喘致病因素和相应处理措施。结果:经分析后得知,父亲哮喘、母亲哮喘、母亲孕期使用过敏药物、过敏体质、被动吸烟、感染等因素均和对照组存在明显性差异(P0.05)。结论:支气管哮喘疾病致病因素具有多种性,其中占主要地位的为体质因素和遗传因素,目前,针对此疾病的治疗多以控制为主,降低疾病复发可能性,给予健康教育等。%Objective:To study the pathogenic factors and the corresponding treatment measures of bronchial asthma. Methods: from July may 2013 to 2015 in our hospital during the period of receiving the treatment of bronchial asthma patients were randomly selected 56 cases as the case study object, the 56 cases of patients were divided into study group, and then select the same period of 56 cases of our hospital in healthy volunteers as control group, a retrospective analysis of clinical data of the study group object, summarizes the risk factors for bronchial asthma and the corresponding treatment measures. Results:after analysis that, father asthma, asthmatic mothers, pregnant use drug allergy, allergic constitution, passive smoking, infection and other factors and the control group there was a significant difference (P0.05). Conclusion: the factors of bronchial asthma disease has a variety of, the accounts for the main position of physical factors and genetic factors. At present, this disease treatment of multi to control mainly, reduce the possibility of recurrent disease, health education was given to them.

  18. Epidemiological observation and risk factors analysis of bronchial asthma%支气管哮喘流行病学观察以及危险因素分析

    Institute of Scientific and Technical Information of China (English)

    贺娟梅; 李小荣; 李复红

    2015-01-01

    Objective To investigate the epidemiological characteristics and analyze the risk factors of bronchial asthma in Weinan area, and to provide evidences for the prevention and treatment. Methods The stratified cluster disproportional random sampling sur-vey and home questionnaire were performed. Results A total of 5 894 valid questionnaires were collected. Four hundred bronchial asthma patients were found, and the overall prevalence rate of bronchial asthma was 6. 79%. The highest prevalence rate was 13. 05%for 0-15 years old population and 10. 56% for 55-64 years old population. The prevalence rates in male populations of 55-64 years old and >64 years old were significantly lower than those in female. The prevalence rate in other age groups was not significantly dif-ferent. The prevalence rate of population with animal husbandry and chemical industry was the highest, 11.17% and 10. 13%. The prevalence rate of asthma peaked in June(15. 00%) and September(13. 25%). Family history, allergen exposure, smoking, other al-lergic diseases were the main risk factors of bronchial asthma. Logistic regression analysis showed family history and other allergic dis-eases were the independent risk factors of asthma attacks. Conclusion The prevalence rate of bronchial asthma in female population in Weinan area is significantly higher than that in male. Many factors are closely related to the onset of bronchial asthma, and family history of asthma and other allergic diseases are the independent risk factors.%目的:探讨渭南地区支气管哮喘的流行病学特征,并分析发病危险因素,为支气管哮喘的防治提供依据。方法采取分层整群不等比随机抽样对照法以及入户问卷填写方式进行抽样调查分析。结果本次调查共收集有效问卷5894份,发现支气管哮喘患者400例,总发病率6.79%。发病高峰年龄段为0-15岁和55-64岁,发病率分别为13.05%和10.56%;55-64岁、>64岁两个年龄段男

  19. Evaluation of multidrug resistance-1 gene C>T polymorphism frequency in patients with asthma

    Directory of Open Access Journals (Sweden)

    Ümran Toru

    2015-10-01

    Full Text Available OBJECTIVES:Asthma is a chronic inflammatory lung disease characterized by bronchial hyperresponsiveness and airflow obstruction. Genetic and oxidative stress factors, in addition to pulmonary and systemic inflammatory processes, play a pivotal role in the pathogenesis of asthma. The products of the multidrug resistance-1 gene protect lung tissue from oxidative stress. Here, we aimed to evaluate the association between the multidrug resistance-1 gene C>T polymorphism and asthma with regard to oxidative stress-related parameters of asthmatic patients.METHODS:Forty-five patients with asthma and 27 healthy age-matched controls were included in this study. Blood samples were collected in tubes with ethylenediaminetetraacetic acid. DNA was extracted from the blood samples. The multidrug resistance-1 gene polymorphism was detected by polymerase chain reaction and a subsequent enzyme digestion technique. The serum levels of total oxidant status and total antioxidant status were determined by the colorimetric measurement method.RESULTS:The heterozygous polymorphic genotype was the most frequent in both groups. A significant difference in the multidrug resistance-1 genotype frequencies between groups indicated an association of asthma with the TT genotype. A significant difference between groups was found for wild type homozygous participants and carriers of polymorphic allele participants. The frequency of the T allele was significantly higher in asthmatic patients. The increase in the oxidative stress index parameter was significant in the asthma group compared with the control group.CONCLUSIONS:The multidrug resistance-1 gene C/T polymorphism may be an underlying genetic risk factor for the development of asthma via oxidant-antioxidant imbalance, leading to increased oxidative stress.

  20. Comparison of pulmonary function in patients with COPD, asthma-COPD overlap syndrome, and asthma with airflow limitation

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    Kitaguchi Y

    2016-05-01

    Full Text Available Yoshiaki Kitaguchi, Masanori Yasuo, Masayuki Hanaoka First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan Background: This study was conducted in order to investigate the differences in the respiratory physiology of patients with chronic obstructive pulmonary disease (COPD, asthma-COPD overlap syndrome (ACOS, and asthma with airflow limitation (asthma FL+. Methods: The medical records for a series of all stable patients with persistent airflow limitation due to COPD, ACOS, or asthma were retrospectively reviewed and divided into the COPD group (n=118, the ACOS group (n=32, and the asthma FL+ group (n=27. All the patients underwent chest high-resolution computed tomography (HRCT and pulmonary function tests, including respiratory impedance. Results: The low attenuation area score on chest HRCT was significantly higher in the COPD group than in the ACOS group (9.52±0.76 vs 5.09±1.16, P<0.01. The prevalence of bronchial wall thickening on chest HRCT was significantly higher in the asthma FL+ group than in the COPD group (55.6% vs 25.0%, P<0.01. In pulmonary function, forced expiratory volume in 1 second (FEV1 and peak expiratory flow rate were significantly higher in the asthma FL+ group than in the ACOS group (76.28%±2.54% predicted vs 63.43%±3.22% predicted, P<0.05 and 74.40%±3.16% predicted vs 61.08%±3.54% predicted, P<0.05, respectively. Although residual volume was significantly lower in the asthma FL+ group than in the COPD group (112.05%±4.34% predicted vs 137.38%±3.43% predicted, P<0.01 and the ACOS group (112.05%±4.34% predicted vs148.46%±6.25% predicted, P<0.01, there were no significant differences in functional residual capacity or total lung capacity. The increase in FEV1 in response to short-acting ß2-agonists was significantly greater in the ACOS group than in the COPD group (229±29 mL vs 72±10 mL, P<0.01 and the asthma FL+ group (229±29 mL vs 153±21 mL, P<0.05. Regarding

  1. Progress in the study of bronchial asthma phenotypes and endotypes%支气管哮喘的表型及内型研究进展

    Institute of Scientific and Technical Information of China (English)

    白雪(综述); 胡红(审阅)

    2016-01-01

    Bronchial asthma is a heterogeneous disease , which has complex pathogenesis , genetics and molecular mechanism.In recent years, aimed at the heterogeneity of asthma , researches about asthma phenotypes and endotypes are be -ing carried out, which will help diagnose, manage and treat asthma.In addition, individual treatment strategies , which based on the researches, will contribute to enhancing the curative effect , decreasing acute episode and reducing the mortality .%支气管哮喘是一种异质性疾病,造成这种异质性的原因是哮喘复杂多样的发病机制、遗传学及分子机制。近年来,针对哮喘的异质性,逐渐开展了对其表型(phenotypes)和内型(endotypes)的研究,这将有助于哮喘的诊断、管理及制定个体化治疗方案,对提高哮喘疗效、减少急性发作及降低病死率具有重要意义。

  2. 糖皮质激素在支气管哮喘治疗中的进展%Research advances on treatment of glncocorticoid in bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    余力; 谢正福

    2008-01-01

    支气管哮喘(简称哮喘)是由多种免疫细胞(如肥大细胞、嗜酸粒细胞、T细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的变态反应性疾病.目前哮喘的药物治疗中主要包括糖皮质激素,很多研究从糖皮质激素治疗哮喘的机制着手,探讨其作用于哮喘的多个环节.%Bronchial asthma(asthma) is an allergic disorder of lung participated by many sorts of immunocytes and cellular components. Current pharmaceutical treatments for asthma generally include the glucocorticoid,and lots of researches go to further the mechanism of glucocorticoid action,all those results will hopefully approach to the effect on component elements of asthma.