WorldWideScience

Sample records for bringing medical discoveries

  1. Medical knowledge discovery and management.

    Science.gov (United States)

    Prior, Fred

    2009-05-01

    Although the volume of medical information is growing rapidly, the ability to rapidly convert this data into "actionable insights" and new medical knowledge is lagging far behind. The first step in the knowledge discovery process is data management and integration, which logically can be accomplished through the application of data warehouse technologies. A key insight that arises from efforts in biosurveillance and the global scope of military medicine is that information must be integrated over both time (longitudinal health records) and space (spatial localization of health-related events). Once data are compiled and integrated it is essential to encode the semantics and relationships among data elements through the use of ontologies and semantic web technologies to convert data into knowledge. Medical images form a special class of health-related information. Traditionally knowledge has been extracted from images by human observation and encoded via controlled terminologies. This approach is rapidly being replaced by quantitative analyses that more reliably support knowledge extraction. The goals of knowledge discovery are the improvement of both the timeliness and accuracy of medical decision making and the identification of new procedures and therapies.

  2. Bringing the best of medical librarianship to the patient team

    OpenAIRE

    Shearer, Barbara S.; Seymour, Anne; Capitani, Cheryl

    2002-01-01

    This article introduces a series of articles examining the state of the medical library profession as practiced in the clinical context. It is widely understood that many changes across the spectrum of medical librarianship practice have been brought about by both technological advances and economic realities. These changes have created strains felt by many in the profession. Discussions of evolving roles for medical librarians that have gone on for years have taken on a new sense of urgency,...

  3. Bringing patient centricity to diabetes medication access in Canada

    Science.gov (United States)

    Glennie, Judith L; Kovacs Burns, Katharina; Oh, Paul

    2016-01-01

    Canada must become proactive in addressing type 2 diabetes. With the second highest rate of diabetes prevalence in the developed world, the number of Canadians living with diabetes will soon reach epidemic levels. Against international comparisons, Canada also performs poorly with respect to diabetes-related hospitalizations, mortality rates, and access to medications. Diabetes and its comorbidities pose a significant burden on people with diabetes (PWD) and their families, through out-of-pocket expenses for medications, devices, supplies, and the support needed to manage their illness. Rising direct and indirect costs of diabetes will become a drain on Canada’s economy and undermine the financial stability of our health care system. Canada’s approach to diabetes medication assessment and funding has created a patchwork of medication access across provinces. Access to treatments for those who rely on public programs is highly restricted compared to Canadians with private drug plans, as well in contrast with public payers in other countries. Each person living with diabetes has different needs, so a “patient-centric” approach ensures treatment focused on individual circumstances. Such tailoring is difficult to achieve, with the linear approach required by public payers. We may be undermining optimal care for PWD because of access policies that are not aligned with individualized approaches – and increasing overall health care costs in the process. The scope of Canada’s diabetes challenge demands holistic and proactive solutions. Canada needs to get out from “behind the eight ball” and get “ahead of the curve” when it comes to diabetes care. Improving access to medications is one of the tools for getting there. Canada’s “call to action” for diabetes starts with effective implementation of existing best practices. A personalized approach to medication access, to meet individual needs and optimize outcomes, is also a key enabler. PWD and

  4. Memantic: A Medical Knowledge Discovery Engine

    OpenAIRE

    Yavlinsky, Alexei

    2015-01-01

    We present a system that constructs and maintains an up-to-date co-occurrence network of medical concepts based on continuously mining the latest biomedical literature. Users can explore this network visually via a concise online interface to quickly discover important and novel relationships between medical entities. This enables users to rapidly gain contextual understanding of their medical topics of interest, and we believe this constitutes a significant user experience improvement over c...

  5. An Antique Microscope Slide Brings the Thrill of Discovery into a Contemporary Biology Classroom

    Science.gov (United States)

    Reiser, Frank

    2012-01-01

    The discovery of a Victorian-era microscope slide titled "Grouped Flower Seeds" began an investigation into the scientific and historical background of the antique slide to develop its usefulness as a multidisciplinary tool for PowerPoint presentations usable in contemporary biology classrooms, particularly large-enrollment sections. The resultant…

  6. eLab: bringing together people, data and methods to enhance knowledge discovery in healthcare settings.

    Science.gov (United States)

    Ainsworth, John; Cunningham, James; Buchan, Iain

    2012-01-01

    The discovery of knowledge from raw data is a multistage process, that typical requires collaboration between experts from disparate disciplines, and the application of a range of methods tailored to the research question. The aim of the eLab is to provide a web-based environment for health professionals and researchers to access health datasets, share knowledge and expertise and to apply methods for analysis and visualization of the results. The eLab is built around the core concept of the Research Object as the mechanism for preserving, reusing and disseminating the knowledge discovery process. The possible range of applications of the eLab is vast, and so the consideration of the trade off between specificity and generality is an important one, that is reflected in the requirements. The architecture and implementation of the eLab is described, and we report on the deployment of eLabs for applications in primary care, long-term conditions management, bariatric surgery and public health.

  7. Medical imaging was boosted by the discovery of artificial radioactivity

    International Nuclear Information System (INIS)

    This article draws the history of medical imaging since the discovery of artificial radioactivity in 1934. The author reviews the PET (positron emission tomography) and MRI (magnetic resonance imaging) technologies and presents the recent progress in neuro-sciences that have been made possible by using these 2 technologies. Brain imaging has allowed to show: - the impact of emotions on logical mental processes and on mental performances, - the management of memory in the brain of talented quick reckoners, - the degeneration of neurons, and - the link between autism and the presence of structural and functional anomalies in the brain. (A.C.)

  8. Catalysts for better health care. Medical tissue banks bring multiple benefits to countries

    International Nuclear Information System (INIS)

    For millions of injured and disabled people around the world, the treatment brings a new quality of life. Called tissue grafting or transplantation, it relies on the use of sterilized bone, skin, and other tissues to heal serious injuries, wounds, and sickness. Prime beneficiaries include severe burn victims, and men, women, and children suffering from crippling diseases, birth defects, and blindness. Long applied in plastic and orthopaedic surgery, tissue grafting once relied only on using a patient's own tissues, known as an autograft. But now tissues from human or animal donors (allograft) are used for transplantation. This new form of tissue grafting has made big strides over the past decade. An expanding number of facilities today prepare the valuable tissues to the high-quality standards demanded in medical care. Dozens of such new tissue banks have opened in Asia, Latin America, Europe, and North America. A productive channel of progress has been an IAEA-supported technical cooperation programme. Through it, experts have worked together behind the scenes to help national health authorities establish tissue banks, train associated staff, and develop standards and regulatory guides. The IAEA accordingly has gained more experience and success than any other international organization in supporting the establishment of tissue banks for medical use in developing countries. Increasingly for quality and cost reasons, the technology of irradiation is used to sterilize tissues for medical care. The IAEA, through its technical cooperation channels, assists national atomic energy authorities to safely and productively employ radiation technology. An interregional programme on radiation and tissue banking, initiated over a decade ago, today extends to 30 countries

  9. Model for a merger: New York-Presbyterian's use of service lines to bring two academic medical centers together.

    Science.gov (United States)

    Corwin, Steven J; Cooper, Mary Reich; Leiman, Joan M; Stein, Dina E; Pardes, Herbert; Berman, Michael A

    2003-11-01

    NewYork-Presbyterian Hospital is the result of the 1998 merger of two large New York City academic medical centers, the former New York and Presbyterian Hospitals, and is affiliated with two independent medical schools, the Columbia University College of Physicians and Surgeons and the Joan and Sanford J. Weill Medical College of Cornell University. At the time of the merger, the hospital faced a number of significant challenges, chief among them the clinical integration of the two medical centers. Size, separate medical schools, geography, and different histories and cultures all presented barriers to collaboration. To bring about the needed clinical alignment, the hospital turned to service lines as a way to realize the benefits of clinical integration without forcing the consolidation of departments. In this article, members of the hospital's senior management review the thinking behind the hospital's use of the service lines, their development and operation, and the significant, positive effects they have had on volume, clinical quality, clinical efficiency, best practices, and revenue management. They discuss how the service lines were used to bring together the two clinical cultures, the impact they have had on the way the hospital is operated and managed, and why service lines have worked at NewYork-Presbyterian in contrast to other hospitals that tried and abandoned them. Service lines play an increasingly central role in the hospital's clinical and business strategies, and are being extended into the NewYork-Presbyterian health care system.

  10. Bringing science to medicine: an interview with Larry Weed, inventor of the problem-oriented medical record.

    Science.gov (United States)

    Wright, Adam; Sittig, Dean F; McGowan, Julie; Ash, Joan S; Weed, Lawrence L

    2014-01-01

    Larry Weed, MD is widely known as the father of the problem-oriented medical record and inventor of the now-ubiquitous SOAP (subjective/objective/assessment/plan) note, for developing an electronic health record system (Problem-Oriented Medical Information System, PROMIS), and for founding a company (since acquired), which developed problem-knowledge couplers. However, Dr Weed's vision for medicine goes far beyond software--over the course of his storied career, he has relentlessly sought to bring the scientific method to medical practice and, where necessary, to point out shortcomings in the system and advocate for change. In this oral history, Dr Weed describes, in his own words, the arcs of his long career and the work that remains to be done.

  11. Teaching English to the medical profession. Developing communication skills and bringing humanities to medicine

    Directory of Open Access Journals (Sweden)

    Jonathan McFarland

    2009-12-01

    Full Text Available This is a personal account of teaching English for medical purposes (EMP, explaining my interest in helping health professionals in Majorca improve their English. My main aim has been to enable them to communicate both orally at medical conferences and in written form for journals. The article explains how the teaching has been a twofold experience, with the professionals explaining their different specialities, while I have provided them with the necessary linguistic tools. Presentations have been integral to this, with humanities in medicine being a theme underlying the entire approach. The article concludes with a small section on the future of English in a medical context. ------------------------------------------------------- Enseñar inglés a los médicos: desarrollo de las habilidades de comunicación y acercamiento de las humanidades a la medicina. Este es un relato personal de mi experiencia en la enseñanza de inglés con fines médicos (IFM, en el que explico mi interés en ayudar a los profesionales sanitarios de Mallorca a mejorar su nivel de inglés. Mi objetivo principal ha sido capacitarlos para que pudieran comunicarse verbalmente en conferencias médicas y por escrito en las publicaciones correspondientes. Doy cuenta en él de la dualidad de la experiencia adquirida durante la enseñanza, en la que los profesionales explicaban sus distintas especializaciones mientras yo les proporcionaba las herramientas lingüísticas necesarias. Las presentaciones han sido un elemento crítico del proceso, y las humanidades médicas un tema subyacente al enfoque integral del proyecto. El artículo finaliza con una pequeña sección acerca del futuro del inglés en el contexto médico.

  12. Africa's middle class women bring entrepreneurial opportunities in breast care medical tourism to South Africa.

    Science.gov (United States)

    Ahwireng-Obeng, Frederick; van Loggerenberg, Charl

    2011-01-01

    Africa's distribution of specialized private health services is severely disproportionate. Mismatch between South Africa's excess supply and a huge demand potential in an under-serviced continent represents an entrepreneurial opportunity to attract patients to South Africa for treatment and recuperative holidays. However, effective demand for intra-African medical tourism could be constrained by sub-Saharan poverty. Results from interviewing 320 patients and five staff at the Johannesburg Breast care Centre of Excellence, however, reject this proposition, Africa's middle class women being the target market estimated to grow annually by one million while breast cancer incidence increases with middle-class lifestyles. Uncovering this potential involves an extensive marketing strategy. PMID:22392794

  13. DOES DIFFERENT STAGES OF MEDICAL EDUCATION WILL BRING CHANGES IN ATTITUDE TOWARDS RURAL HEALTH SERVICES?

    Directory of Open Access Journals (Sweden)

    Sandeep

    2015-01-01

    Full Text Available OBJECTIVE: To know attitude for rural health service in students of different stages of medical education like undergraduate (third year MBBS students , internship doing student and post graduates students. MATERIALS & METHOD : The present cross sectional study was conducted at Governement Medical C ollege , Nagpur in month of august to November 2014 in predesigned and pretested proform. The proforma includes information about parents regarding socioeconomic status their occupation literacy status a nd also information regarding willingness to work in rural health services and different reasons for not giving health services to rural areas like political unstable area , no entertainments , no future , not having better leaving conditions , no proper educa tion for their kids etc . Informed consent was taken prior to inclusion into the study . Three different medical educating students i.e 69 % (99 third MBBS students , 54% (Interns 87 students and 47% (61 postgraduates students. RESULTS: Undergraduate stude nt and in interns female students are more than male students and they are71 (72 % and 50(57% respectively. Most of the study participants are residing in urban areas i.e. 63 (63.6% undergraduates , 58(66.7% interns and 49(80.3% students in postgraduat es are having urban is the place of residence. 54(76% female students from undergraduates and 32 (64% female students from interns and 15(68.1% female students from postgraduates are willing to serve for rural health. female undergraduates students (88. 7%accepted rural area is unstable to work when compared with male undergraduates (42.9% and this difference found to be statistically significant (p=0.001.Majority of female undergraduates(69% accepted that there is no personal safety in rural areas as compared with male undergraduates(17.9%.This difference also found to be significant (p=0.001.Isolation and remoteness of the location of health facility was accepted by most of the female

  14. Community-oriented medical education: bringing perspectives to curriculum planners in Damascus University.

    Science.gov (United States)

    Dashash, Mayssoon

    2013-01-01

    The varying health needs in Syria because of the trend of increasing communicable and noncommunicable diseases necessitate new curricula for all health professions schools in which community health needs, socio-cultural aspects of health and disease can be emphasized. There is a need to produce more primary level healthcare professionals who are trained to apply the principles, policies and strategies of the World Health Organization and achieve better health for all. A new perspective in the Faculty of Dentistry in Damascus University has been suggested and is presented here. Graduates generally are not well prepared to provide primary level healthcare in the community. Community-oriented medical education (COME) can produce health-oriented professionals who are equipped with broad skills and able to work for health promotion, disease prevention, and cure. Health orientation is one of the most radical features of COME, wherein the curriculum is appropriate to learners' future practice in the community. Community orientation enables students to become more people focused so that they can work towards people's self-empowerment, change people's attitudes and behaviors, and improve their self-awareness and esteem. This viewpoint addresses the importance of redesigning the dental curriculum and the need to implement COME in Damascus University. It is proposed as an example of changes needed in all health professions schools in Syria. The call to redesign the curricula to serve the health needs of the Syrian population will be difficult to achieve but is vital. Improving our understanding of the concept of COME and having all sectors of government and society commit to it will make the transition possible and will make the COME a reality. PMID:24200737

  15. Text mining for traditional Chinese medical knowledge discovery: a survey.

    Science.gov (United States)

    Zhou, Xuezhong; Peng, Yonghong; Liu, Baoyan

    2010-08-01

    Extracting meaningful information and knowledge from free text is the subject of considerable research interest in the machine learning and data mining fields. Text data mining (or text mining) has become one of the most active research sub-fields in data mining. Significant developments in the area of biomedical text mining during the past years have demonstrated its great promise for supporting scientists in developing novel hypotheses and new knowledge from the biomedical literature. Traditional Chinese medicine (TCM) provides a distinct methodology with which to view human life. It is one of the most complete and distinguished traditional medicines with a history of several thousand years of studying and practicing the diagnosis and treatment of human disease. It has been shown that the TCM knowledge obtained from clinical practice has become a significant complementary source of information for modern biomedical sciences. TCM literature obtained from the historical period and from modern clinical studies has recently been transformed into digital data in the form of relational databases or text documents, which provide an effective platform for information sharing and retrieval. This motivates and facilitates research and development into knowledge discovery approaches and to modernize TCM. In order to contribute to this still growing field, this paper presents (1) a comparative introduction to TCM and modern biomedicine, (2) a survey of the related information sources of TCM, (3) a review and discussion of the state of the art and the development of text mining techniques with applications to TCM, (4) a discussion of the research issues around TCM text mining and its future directions.

  16. Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development.

    Science.gov (United States)

    Litten, Raye Z; Falk, Daniel E; Ryan, Megan L; Fertig, Joanne B

    2016-07-01

    For more than 25 years, advances have been made in developing medications to treat alcohol use disorder (AUD), highlighted by the U.S. Food and Drug Administration's approval of naltrexone (oral and long-acting) and acamprosate. Despite this progress, more work remains to be done in this area because these medications, although effective for some people, do not work for everyone. A high priority for the National Institute on Alcohol Abuse and Alcohol is to put into place a solid infrastructure to aid in the development of medications that are more effective than those currently available and with few side effects. Medication development, especially for a disorder as complex as AUD, is challenging and involves multiple phases, including discovery of "druggable" targets, preclinical studies, human clinical trials, and the adoption and implementation of the new medication into mainstream medicine. A successful medications development program requires clearly established goals for each phase to ensure that a candidate compound is not trapped in one particular phase, a condition known as "the valley of death." In this article, the phases of medication development are described as they apply to AUD, and specific goals of each phase are identified for the next decade. In addition, several important crosscutting themes are outlined for each phase, all of which are essential for advancing medications development. These include identifying and validating screening models and druggable targets, making use of precision medicine, and establishing partnerships among key stakeholders. Our goal in writing this article is to provide a guide on medications development that will aid the alcohol research community in planning, testing, and developing medications for AUD. PMID:27184259

  17. Discovery, Development, and Adoption of Medications to Treat Alcohol Use Disorder: Goals for the Phases of Medications Development.

    Science.gov (United States)

    Litten, Raye Z; Falk, Daniel E; Ryan, Megan L; Fertig, Joanne B

    2016-07-01

    For more than 25 years, advances have been made in developing medications to treat alcohol use disorder (AUD), highlighted by the U.S. Food and Drug Administration's approval of naltrexone (oral and long-acting) and acamprosate. Despite this progress, more work remains to be done in this area because these medications, although effective for some people, do not work for everyone. A high priority for the National Institute on Alcohol Abuse and Alcohol is to put into place a solid infrastructure to aid in the development of medications that are more effective than those currently available and with few side effects. Medication development, especially for a disorder as complex as AUD, is challenging and involves multiple phases, including discovery of "druggable" targets, preclinical studies, human clinical trials, and the adoption and implementation of the new medication into mainstream medicine. A successful medications development program requires clearly established goals for each phase to ensure that a candidate compound is not trapped in one particular phase, a condition known as "the valley of death." In this article, the phases of medication development are described as they apply to AUD, and specific goals of each phase are identified for the next decade. In addition, several important crosscutting themes are outlined for each phase, all of which are essential for advancing medications development. These include identifying and validating screening models and druggable targets, making use of precision medicine, and establishing partnerships among key stakeholders. Our goal in writing this article is to provide a guide on medications development that will aid the alcohol research community in planning, testing, and developing medications for AUD.

  18. The feasibility of using 'bring your own device' (BYOD) technology for electronic data capture in multicentre medical audit and research.

    Science.gov (United States)

    Faulds, M C; Bauchmuller, K; Miller, D; Rosser, J H; Shuker, K; Wrench, I; Wilson, P; Mills, G H

    2016-01-01

    Large-scale audit and research projects demand robust, efficient systems for accurate data collection, handling and analysis. We utilised a multiplatform 'bring your own device' (BYOD) electronic data collection app to capture observational audit data on theatre efficiency across seven hospital Trusts in South Yorkshire in June-August 2013. None of the participating hospitals had a dedicated information governance policy for bring your own device. Data were collected by 17 investigators for 392 individual theatre lists, capturing 14,148 individual data points, 12, 852 (91%) of which were transmitted to a central database on the day of collection without any loss of data. BYOD technology enabled accurate collection of a large volume of secure data across multiple NHS organisations over a short period of time. Bring your own device technology provides a method for collecting real-time audit, research and quality improvement data within healthcare systems without compromising patient data protection. PMID:26526934

  19. The feasibility of using 'bring your own device' (BYOD) technology for electronic data capture in multicentre medical audit and research.

    Science.gov (United States)

    Faulds, M C; Bauchmuller, K; Miller, D; Rosser, J H; Shuker, K; Wrench, I; Wilson, P; Mills, G H

    2016-01-01

    Large-scale audit and research projects demand robust, efficient systems for accurate data collection, handling and analysis. We utilised a multiplatform 'bring your own device' (BYOD) electronic data collection app to capture observational audit data on theatre efficiency across seven hospital Trusts in South Yorkshire in June-August 2013. None of the participating hospitals had a dedicated information governance policy for bring your own device. Data were collected by 17 investigators for 392 individual theatre lists, capturing 14,148 individual data points, 12, 852 (91%) of which were transmitted to a central database on the day of collection without any loss of data. BYOD technology enabled accurate collection of a large volume of secure data across multiple NHS organisations over a short period of time. Bring your own device technology provides a method for collecting real-time audit, research and quality improvement data within healthcare systems without compromising patient data protection.

  20. Knowledge discovery in medical systems using differential diagnosis, LAMSTAR & k-NN.

    Science.gov (United States)

    Isola, Rahul; Carvalho, Rebeck; Tripathy, Amiya Kumar

    2012-11-01

    Medical data is an ever-growing source of information generated from the hospitals in the form of patient records. When mined properly the information hidden in these records is a huge resource bank for medical research. As of now, this data is mostly used only for clinical work. This data often contains hidden patterns and relationships, that can lead to better diagnosis, better medicines, better treatment and overall, a platform to better understand the mechanisms governing almost all aspects of the medical domain. Unfortunately, discovery of these hidden patterns and relationships often goes unexploited. However there is on-going research in medical diagnosis which can predict the diseases of the heart, lungs and various tumours based on the past data collected from the patients.They are mostly limited to domain specific systems that predict diseases restricted to their area of operation like heart, brain and various other domains. These are not applicable to the whole medical dataset. The system proposed in this paper uses this vast storage of information so that diagnosis based on this historical data can be made. It focuses on computing the probability of occurrence of a particular ailment from the medical data by mining it using a unique algorithm which increases accuracy of such diagnosis by combining the key points of Neural Networks, Large Memory Storage and Retrieval (LAMSTAR), k-NN and Differential Diagnosis all integrated into one single algorithm. The system uses a Service-Oriented Architecture wherein the system components of diagnosis, information portal and other miscellaneous services are provided.This algorithm can be used in solving a few common problems that are encountered in automated diagnosis these days, which include: diagnosis of multiple diseases showing similar symptoms, diagnosis of a person suffering from multiple diseases, receiving faster and more accurate second opinion and faster identification of trends present in the medical

  1. Action Experience and Action Discovery in Medicated Individuals with Parkinson’s Disease

    Science.gov (United States)

    Bednark, Jeffery G.; Reynolds, John N. J.; Stafford, Tom; Redgrave, Peter; Franz, Elizabeth A.

    2016-01-01

    Parkinson’s disease (PD) is a neurodegenerative disorder that markedly affects voluntary action. While regular dopamine treatment can help restore motor function, dopamine also influences cognitive portions of the action system. Previous studies have demonstrated that dopamine medication boosts action-effect associations, which are crucial for the discovery of new voluntary actions. In the present study, we investigated whether neural processes involved in the discovery of new actions are altered in PD participants on regular dopamine treatment, compared to healthy age-matched controls. We recorded brain electroencephalography (EEG) activity while PD patients and age-matched controls performed action discovery (AD) and action control tasks. We found that the novelty P3, a component normally present when there is uncertainty about the occurrence of the sensory effect, was enhanced in PD patients. However, AD was maintained in PD patients, and the novelty P3 demonstrated normal learning-related reductions. Crucially, we found that in PD patients the causal association between an action and its resulting sensory outcome did not modulate the amplitude of the feedback correct-related positivity (fCRP), an EEG component sensitive to the association between an action and its resulting effect. Collectively, these preliminary results suggest that the formation of long-term action-outcome representations may be maintained in PD patients on regular dopamine treatment, but the initial experience of action-effect association may be affected.

  2. "What Brings Him Here Today?": Medical Problem Presentation Involving Children with Autism Spectrum Disorders and Typically Developing Children

    Science.gov (United States)

    Solomon, Olga; Heritage, John; Yin, Larry; Maynard, Douglas W.; Bauman, Margaret L.

    2016-01-01

    Conversation and discourse analyses were used to examine medical problem presentation in pediatric care. Healthcare visits involving children with ASD and typically developing children were analyzed. We examined how children's communicative and epistemic capabilities, and their opportunities to be socialized into a competent patient role are…

  3. Drug discovery and development for Huntington's disease - an orphan indication with high medical need.

    Science.gov (United States)

    Heitz, Freddy; La Rosa, Salvatore; Gonzalez-Couto, Eduardo; Gaviraghi, Giovanni; Terstappen, Georg C

    2008-09-01

    Huntington's disease (HD) is a rare neurodegenerative disorder that progressively destroys the mental capacity and motor control of patients. This loss of motor control results in abnormal body movements (chorea) - the hallmark of HD. Given that no disease-modifying therapy for HD exists and that available symptomatic treatments are not highly efficacious, the medical need for this 'orphan' disease remains high. The number of compounds that are undergoing discovery and development for the treatment of HD has increased significantly in recent years, spurred by legislative incentives for orphan drug development and by support from non-profit foundations. Thus, hope exists for patients with HD that efficacious medicines will become available. PMID:18763216

  4. Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments

    Directory of Open Access Journals (Sweden)

    Xin-Qing Zhao

    2011-01-01

    Full Text Available Marine microorganisms are rich source for natural products which play important roles in pharmaceutical industry. Over the past decade, genome-based studies of marine microorganisms have unveiled the tremendous diversity of the producers of natural products and also contributed to the efficiency of harness the strain diversity and chemical diversity, as well as the genetic diversity of marine microorganisms for the rapid discovery and generation of new natural products. In the meantime, genomic information retrieved from marine symbiotic microorganisms can also be employed for the discovery of new medical molecules from yet-unculturable microorganisms. In this paper, the recent progress in the genomic research of marine microorganisms is reviewed; new tools of genome mining as well as the advance in the activation of orphan pathways and metagenomic studies are summarized. Genome-based research of marine microorganisms will maximize the biodiscovery process and solve the problems of supply and sustainability of drug molecules for medical treatments.

  5. Remote Forensics May Bring the Next Sea Change in E-discovery: Are All Networked Computers Now Readily Accessible Under the Revised Federal Rules of Civil Procedure?

    Directory of Open Access Journals (Sweden)

    AleJoseph J. Schwerha

    2008-09-01

    Full Text Available The recent amendments to Rule 26 of the Federal Rules of Civil Procedure created a two-tiered approach to discovery of electronically stored information (“ESI”. Responding parties must produce ESI that is relevant, not subject to privilege, and reasonably accessible. However, because some methods of storing ESI, such as on magnetic backup tapes and within enormous databases, require substantial cost to access and search their contents, the rules permit parties to designate those repositories as “not reasonably accessible” because of undue burden or cost. But even despite the difficulty in searching for ESI, the party’s duty to preserve potentially responsive evidence remains; it simply gains the option to forgo poring over the material. Further, the court might nevertheless compel production if the requesting party demonstrates good cause.Regardless of whether the responding party believes certain documents to be reasonably accessible or not, courts may still require their production.   In such cases, the court may then choose to order production, but shift the costs of doing so to the requesting party.  Throughout this process, the burden and cost of production are central themes.   Their determination is fluid, varying from case to case and even over time in the same situation.   Nowhere is this more evident than where a responding party has numerous, geographically dispersed computers under its control that may contain responsive ESI to a request for production of documents.  Traditionally, a responding party would be forced to make a decision of whether or not to send out computer forensic experts to all of these locations to make forensically sound copies of all of those computers and then analyze each.   This process is time consuming and costly.  Recently, several companies have put forth substantial solutions that facially allow a responding party to capture and analyze data

  6. Combining knowledge discovery from databases (KDD) and case-based reasoning (CBR) to support diagnosis of medical images

    Science.gov (United States)

    Stranieri, Andrew; Yearwood, John; Pham, Binh

    1999-07-01

    The development of data warehouses for the storage and analysis of very large corpora of medical image data represents a significant trend in health care and research. Amongst other benefits, the trend toward warehousing enables the use of techniques for automatically discovering knowledge from large and distributed databases. In this paper, we present an application design for knowledge discovery from databases (KDD) techniques that enhance the performance of the problem solving strategy known as case- based reasoning (CBR) for the diagnosis of radiological images. The problem of diagnosing the abnormality of the cervical spine is used to illustrate the method. The design of a case-based medical image diagnostic support system has three essential characteristics. The first is a case representation that comprises textual descriptions of the image, visual features that are known to be useful for indexing images, and additional visual features to be discovered by data mining many existing images. The second characteristic of the approach presented here involves the development of a case base that comprises an optimal number and distribution of cases. The third characteristic involves the automatic discovery, using KDD techniques, of adaptation knowledge to enhance the performance of the case based reasoner. Together, the three characteristics of our approach can overcome real time efficiency obstacles that otherwise mitigate against the use of CBR to the domain of medical image analysis.

  7. Medical imaging was boosted by the discovery of artificial radioactivity; L'imagerie medicale revelee par la radioactivite

    Energy Technology Data Exchange (ETDEWEB)

    Demarthon, F.; Dupuy-Maury, F.; Donnars, O

    2002-08-01

    This article draws the history of medical imaging since the discovery of artificial radioactivity in 1934. The author reviews the PET (positron emission tomography) and MRI (magnetic resonance imaging) technologies and presents the recent progress in neuro-sciences that have been made possible by using these 2 technologies. Brain imaging has allowed to show: - the impact of emotions on logical mental processes and on mental performances, - the management of memory in the brain of talented quick reckoners, - the degeneration of neurons, and - the link between autism and the presence of structural and functional anomalies in the brain. (A.C.)

  8. Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.

    Science.gov (United States)

    Nakata, M; Tang, W

    2008-10-01

    The Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008 (JCMWDDT 2008) was held from September 29 to October 1, 2008 at The University of Tokyo, Tokyo, Japan. JCMWDDT is an international workshop that is mainly organized by Asian editorial members of Drug Discoveries & Therapeutics (http://www.ddtjournal.com/home) for the purpose of promoting research exchanges in the field of drug discovery and therapeutic. This year's JCMWDDT is the second workshop and focused particularly on novel development and technological innovation of anti-influenza agents. The workshop began with an announcement by the Japanese Co-chairperson, Dr. Sekimizu (Department of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan; Editorin- Chief of Drug Discoveries & Therapeutics, DDT) followed by a speech by the Chinese Co-chairperson, Dr. Wenfang Xu (School of Pharmaceutical Sciences, Shandong University, Shandong, China; Editor in China Office of DDT), with additional speeches by Dr. Norio Matsuki (The University of Tokyo, Japan; Editor of DDT) and Dr. Guanhua Du (Chinese Academy of Medical Science, China; Editor of DDT). Fifty-nine titles were presented in 6 specialized sessions (Research Advances in Drug Discoveries and Therapeutics, Drug Synthesis/Clinical Therapeutics, Medicinal Chemistry/Natural Products, Anti-influenza Drugs, Anti-infection/antiviral Drugs, Biochemistry/Molecular Biology /Pharmacology) and a poster session (Drug Discov Ther 2008; 2, Suppl; available at http://www.ddtjournal.com/Announce/index.htm). An annual outbreak of avian influenza in Asian countries including China and Japan has sparked fears that the virus will mutate and then cause an epidemic in humans. Therefore, Asian researchers need to work together to control this infection. This year's JCMWDDT helped provide an opportunity to reiterate the crucial role of medicinal chemistry in conquering influenza and created an environment for cooperative

  9. Advancing regulatory science to bring novel medical devices for use in emergency care to market: the role of the Food and Drug Administration.

    Science.gov (United States)

    Scully, Christopher G; Forrest, Shawn; Galeotti, Loriano; Schwartz, Suzanne B; Strauss, David G

    2015-04-01

    The Food and Drug Administration (FDA) performs regulatory science to provide science-based medical product regulatory decisions. This article describes the types of scientific research the FDA's Center for Devices and Radiological Health performs and highlights specific projects related to medical devices for emergency medicine. In addition, this article discusses how results from regulatory science are used by the FDA to support the regulatory process as well as how the results are communicated to the public. Regulatory science supports the FDA's mission to assure safe, effective, and high-quality medical products are available to patients.

  10. Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications

    Science.gov (United States)

    Keefe, Andrew J.

    Controlling nonspecific protein interactions is important for applications from medical devices to protein therapeutics. The presented work is a compilation of efforts aimed at using zwitterionic (ionic yet charge neutral) polymers to modify and stabilize the surface of sensitive biomedical and biological materials. Traditionally, when modifying the surface of a material, the stability of the underlying substrate. The materials modified in this dissertation are unique due to their unconventional amorphous characteristics which provide additional challenges. These are poly(dimethyl siloxane) (PDMS) rubber, and proteins. These materials may seem dissimilar, but both have amorphous surfaces, that do not respond well to chemical modification. PDMS is a biomaterial extensively used in medical device manufacturing, but experiences unacceptably high levels of non-specific protein fouling when used with biological samples. To reduce protein fouling, surface modification is often needed. Unfortunately conventional surface modification methods, such as Poly(ethylene glycol) (PEG) coatings, do not work for PDMS due to its amorphous state. Herein, we demonstrate how a superhydrophilic zwitterionic material, poly(carboxybetaine methacrylate) (pCBMA), can provide a highly stable nonfouling coating with long term stability due to the sharp the contrast in hydrophobicity between pCBMA and PDMS. Biological materials, such as proteins, also require stabilization to improve shelf life, circulation time, and bioactivity. Conjugation of proteins with PEG is often used to increase protein stability, but has a detrimental effect on bioactivity. Here we have shown that pCBMA conjugation improves stability in a similar fashion to PEG, but also retains, or even improves, binding affinity due to enhanced protein-substrate hydrophobic interactions. Recognizing that pCBMA chemically resembles the combination of lysine (K) and glutamic acid (E) amino acids, we have shown how zwitterionic

  11. The OCHIN community information network: bringing together community health centers, information technology, and data to support a patient-centered medical village.

    Science.gov (United States)

    Devoe, Jennifer E; Sears, Abigail

    2013-01-01

    Creating integrated, comprehensive care practices requires access to data and informatics expertise. Information technology (IT) resources are not readily available to individual practices. One model of shared IT resources and learning is a "patient-centered medical village." We describe the OCHIN Community Health Information Network as an example of this model; community practices have come together collectively to form an organization that leverages shared IT expertise, resources, and data, providing members with the means to fully capitalize on new technologies that support improved care. This collaborative facilitates the identification of "problem sheds" through surveillance of network-wide data, enables shared learning regarding best practices, and provides a "community laboratory" for practice-based research. As an example of a community of solution, OCHIN uses health IT and data-sharing innovations to enhance partnerships between public health leaders, clinicians in community health centers, informatics experts, and policy makers. OCHIN community partners benefit from the shared IT resource (eg, a linked electronic health record, centralized data warehouse, informatics, and improvement expertise). This patient-centered medical village provides (1) the collective mechanism to build community-tailored IT solutions, (2) "neighbors" to share data and improvement strategies, and (3) infrastructure to support innovations based on electronic health records across communities, using experimental approaches.

  12. 国家互联网+战略对医疗卫生行业的影响%National Internet+ and Strategy brings Changes to Medical and Health In-dustry

    Institute of Scientific and Technical Information of China (English)

    黄凯; 陆敏

    2016-01-01

    阐述国家互联网+行动战略对医疗卫生行业带来的变革,包括改善患者就诊体验,提高患者满意度;促进医疗卫生行业信息化的开放、融合;帮助建立健康生活和居家养老的解决方案;推进医药分开以及完善供应链和集中采购机制;开发挖掘医疗卫生机构大数据的价值。%This article demonstrates National Internet+and strategy brings changes to Medical and Health industry, includ-ing improving patients visiting experiences and increasing satisfactions, enhancing opening Medical and Health industry in-formation and fusion. It helps building healthy life and home-based care, pushing separatingmedical and pharmaceutical servicesand improving supply chain and centralizing purchasing, developing Medical and Health Institution big-data values.

  13. Bringing focus to entrepreneurship

    NARCIS (Netherlands)

    T. Skelton (Tim); J.J.P. Jansen (Justin)

    2013-01-01

    textabstractFostering entrepreneurship has long been a core part of the RSM ethos. But a new centre bringing together some key players promises to take this philosophy to a new and even more successful level.

  14. Bringing "indigenous" ownership back

    DEFF Research Database (Denmark)

    Kragelund, Peter

    2012-01-01

    understanding of how processes of exclusion interact with domestic politics in Zambia. It argues that the Citizens Economic Empowerment Commission, a new institution to bring ownership back to Zambians, builds on a long tradition of nationalist policies in Zambia, while its actual work is strictly related......African economies are currently experiencing an upsurge in foreign ownership of key parts of their economies. This, however, is not new, and in the wake of independence several African countries pursued indigenisation policies to bring ownership back to their own citizens. Now indigenisation...

  15. 2011 Lasker Clinical Medical Research Award Honors Prof.TU You-you for the Discovery of Artemisinin

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The 2011 Lasker Clinical Medical Research Award honors a scientist who discovered artemisinin and its utility for treating malaria.Prof.TU You-you (China Academy of Chinese Medical Sciences,Beijing) transformed an ancient Chinese healing method into the most powerful antimalarial medicine currently available that has saved millions of lives across the globe,especially in the developing world.

  16. [The history of the Science of Stress: From Hans Selye to the discovery of anti-inflammatory medication].

    Science.gov (United States)

    Lupien, Sonia

    2015-01-01

    To make an important scientific discovery that will make history takes a lot of determination, creativity, perseverance and luck! The story behind the discovery of stress and its biological basis is a fascinating one that places Dr. Hans Selye in the forefront. Dr. Selye was a great scientist that taught at the Université de Montréal from 1945 to his death in 1982. Dr. Selye was curious and hard working. He was determined to understand how various disorders can lead to similar physical manifestations, and this interest led him to discover the role of the adrenal glands involved in the stress response and to better understand the effects of glucocorticoids on the body. Today, the science of stress is based on the foundations established by Dr. Selye. In celebration of the 50th anniversary of the Département de psychiatrie de l'Université de Montréal, and the special issue of the Revue Santé Mentale au Québec, this historical review summarizes the discoveries of this great scientist who worked in Quebec.

  17. Bringing Biocuration to China

    Institute of Scientific and Technical Information of China (English)

    Zhang Zhang; Weimin Zhu; Jingchu Luo

    2014-01-01

    Biocuration involves adding value to biomedical data by the processes of standardiza-tion, quality control and information transferring (also known as data annotation). It enhances data interoperability and consistency, and is critical in translating biomedical data into scientific discovery. Although China is becoming a leading scientific data producer, biocuration is still very new to the Chinese biomedical data community. In fact, there currently lacks an equivalent acknowledged word in Chinese for the word ‘‘curation”. Here we propose its Chinese translation as‘‘审编”(Pinyin:shen bian), based on its implied meanings taken by biomedical data community. The 8th International Biocuration Conference to be held in China (http://biocuration2015.tilsi.org) next year bears the potential to raise the general awareness in China of the significant role of biocuration in scientific discovery. However, challenges are ahead in its implementation.

  18. Medical Journals-The interface between discovery and practice%医学杂志——沟通探索与实践

    Institute of Scientific and Technical Information of China (English)

    Jeffrey Drazen; 王耀丽; 张子强; 白春学

    2009-01-01

    Medical journals exist at the interface between discovery of new knowledge and the clinical practice of medicine. The purpose of journals is to keep physicians and physician-scientists abreast of advances in their field. How to make medical papers published and achieve the level of the highest academic standards is a very complicated process. This article reviews New England Journal on the type of paper, review process, received process,the evaluation process and so on. A better understanding of these process, might lead to better arrangement and publication of your medical paper.%医学杂志是联系医学前沿知识和临床实践的桥梁,是医学科研工作者获得本专业前沿知识和展示成果的主要渠道.如何让医学论文在高影响因子杂志上发表,向公众展示科研工作者的研究成果,是一个非常复杂的过程.本文就如何在新英格兰杂志上发表论文,从论文类型、杂志动态、投稿流程和评审过程等方面进行简要综述.

  19. [Graduate of the S.M.Kirov Military-medical academy Fedor Levin: on the way to discovery of DNA].

    Science.gov (United States)

    Karpuschenko, E G; Deev, R V; Ovchinnikov, D V; Plaska, I L

    2015-10-01

    Biochemist Fedor Aronovich LeviN (1869-1940) graduated with honours from the S.M.Kirov Military Medical Academy in St. Petersburg in 1891 where he had received a fundamental knowledge from A.P.Dianin and I.P.Pavlov, and then he immigrated to the US. More than three and a half decades of his successful research at the Rockefeller Institute for Medical Research contributed to the foundation of the doctrine of nucleic acids. Scientists, who continued to research nucleic acids, were awarded the Nobel Prize, but Levin and his contribution were forgotten. The authors of the given article didn't found any source in Russian about this prominent biochemist of the 20th century and member of the Russian scientific school. The purpose of the article is to acquaint the reader with a scientific biography of the scientist. who became, without exaggeration, one of the founders of modern genetics.

  20. Bringing up Gender: Academic Abjection?

    Science.gov (United States)

    Henderson, Emily F.

    2014-01-01

    The principal questions raised in this article are: what does it mean to bring up the topic of gender in a space where it is not known, and how can this moment of bringing up gender--or not bringing it up--be conceptualised? The article departs from the thoughts and questions that were provoked by an interview conducted with a Gender Studies…

  1. China-Vietnam Friendship Bringing Light Tour

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>At the invitation of the Vietnam Union of Friendship Organizations (VUFO),a delegation headed by CPAFFC Vice President Feng Zuoku and composed of a medical team from Beijing Tongren Hospital made a"China-Vietnam Friendship Bringing Light Tour to Vietnam"from November 13 to 20,2009 and gave free cataract surgery to about 100 patients in Bac Giang Province.

  2. Discovery of a 〈2 1 0〉-fiber texture in medical-grade metastable beta titanium wire

    International Nuclear Information System (INIS)

    The texture and phase evolution of metastable β-III Ti alloy wires, produced in a medical-grade wire-processing facility, are examined via synchrotron X-ray diffraction. The texture development in the β-phase was interpreted by a simple viscoplastic self-consistent (VPSC) modeling approach. Both the stress-induced martensite and stress-induced omega phase transformations are observed during the early stage of cold deformation. The 〈1 1 0〉β texture is gradually replaced by the 〈2 1 0〉β texture at cold work levels above 50% total area reduction or equivalently 0.70 axial true strain. Formation of the 〈2 1 0〉β-fiber from the combined activity of {1 1 2} and {3 3 2} twinning plus conventional slip is observed and may not directly depend upon the stress-induced phase per se. According to the VPSC model, similar texture should occur in other metastable β-Ti alloys subjected to similar wire processing. These data should help inform process–structure–function towards better wire design in titanium-based medical devices

  3. Bringing Gravity to Space

    Science.gov (United States)

    Norsk, P.; Shelhamer, M.

    2016-01-01

    This panel will present NASA's plans for ongoing and future research to define the requirements for Artificial Gravity (AG) as a countermeasure against the negative health effects of long-duration weightlessness. AG could mitigate the gravity-sensitive effects of spaceflight across a host of physiological systems. Bringing gravity to space could mitigate the sensorimotor and neuro-vestibular disturbances induced by G-transitions upon reaching a planetary body, and the cardiovascular deconditioning and musculoskeletal weakness induced by weightlessness. Of particular interest for AG during deep-space missions is mitigation of the Visual Impairment Intracranial Pressure (VIIP) syndrome that the majority of astronauts exhibit in space to varying degrees, and which presumably is associated with weightlessness-induced fluid shift from lower to upper body segments. AG could be very effective for reversing the fluid shift and thus help prevent VIIP. The first presentation by Dr. Charles will summarize some of the ground-based and (very little) space-based research that has been conducted on AG by the various space programs. Dr. Paloski will address the use of AG during deep-space exploration-class missions and describe the different AG scenarios such as intra-vehicular, part-of-vehicle, or whole-vehicle centrifugations. Dr. Clement will discuss currently planned NASA research as well as how to coordinate future activities among NASA's international partners. Dr. Barr will describe some possible future plans for using space- and ground-based partial-G analogs to define the relationship between physiological responses and G levels between 0 and 1. Finally, Dr. Stenger will summarize how the human cardiovascular system could benefit from intermittent short-radius centrifugations during long-duration missions.

  4. Bringing physics to life

    Science.gov (United States)

    2000-01-01

    `I'm doing a physics that is pulling me towards it.' `I like the course being more up to date.' `You learn the physics but you also think ``well I actually see a point in knowing this physics''.' `This course presents physics in a more interesting way as it focuses on practical activity and applications of physics.' `The industrial visit gives students the opportunity to look for science in action.' These are just some of the comments from students and teachers piloting the new Salters Horners Advanced Physics course (SHAP). Contexts and applications drive the course, providing interest and motivation for students and alerting them to some of the many career areas that involve physics. For example, the operation of a CD player leads to a study of waves and superposition; archaeological surveying and analysis brings in d.c. circuitry and x-ray diffraction; consideration of safety in rail transport involves learning about mechanics and electromagnetism. The course is produced by a team directed from the University of York and funded by a consortium of industrial and charitable sponsors. It is examined by Edexcel and support materials are published by Heinemann. The pilot, involving some 50 centres, began in September 1998 with the new subject core and the AS qualification intermediate between GCSE and the full A-level standard. The course has been fully approved by QCA, and from September 2000 it will be open to all. For comprehensive information about SHAP, visit the project's website: www.york.ac.uk/org/seg/salters/physics . Pilot materials for students, teachers and technicians are available from Heinemann. They will be re-edited and published in full colour for September 2000. Members of the team will attend the annual ASE meeting in Leeds this month; there will be a talk and a hands-on workshop where student activities can be sampled. Materials will be on view at the University of York stand. In addition, Edexcel and the York team are running a series of

  5. Ayurvedic drug discovery.

    Science.gov (United States)

    Balachandran, Premalatha; Govindarajan, Rajgopal

    2007-12-01

    Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested evidences vouch immense therapeutic benefits for ayurvedic herbs and formulations, several important issues are required to be resolved for successful implementation of ayurvedic principles to present drug discovery methodologies. Additionally, clinical examination in the extent of efficacy, safety and drug interactions of newly developed ayurvedic drugs and formulations are required to be carefully evaluated. Ayurvedic experts suggest a reverse-pharmacology approach focusing on the potential targets for which ayurvedic herbs and herbal products could bring tremendous leads to ayurvedic drug discovery. Although several novel leads and drug molecules have already been discovered from ayurvedic medicinal herbs, further scientific explorations in this arena along with customization of present technologies to ayurvedic drug manufacturing principles would greatly facilitate a standardized ayurvedic drug discovery.

  6. A discovery solution from Ebsco

    OpenAIRE

    Martín Michavila, Mariano

    2009-01-01

    EBSCO offers complementary access tools to gain greater value from the discovery solution: a customizable, versatile knowledgebase and listing service that enhances discovery, brings more visibility to the library’s collection, get users to specific content, and makes it easier for librarians to manage e-resources. It is an effective tool for end users who may gather information by browsing (journal lists, TOC, etc.), alerting (journal alerts, RSS) or known-item searching.

  7. Clustering and Symbolic Analysis of Cardiovascular Signals: Discovery and Visualization of Medically Relevant Patterns in Long-Term Data Using Limited Prior Knowledge

    Directory of Open Access Journals (Sweden)

    Syed Zeeshan

    2007-01-01

    Full Text Available This paper describes novel fully automated techniques for analyzing large amounts of cardiovascular data. In contrast to traditional medical expert systems our techniques incorporate no a priori knowledge about disease states. This facilitates the discovery of unexpected events. We start by transforming continuous waveform signals into symbolic strings derived directly from the data. Morphological features are used to partition heart beats into clusters by maximizing the dynamic time-warped sequence-aligned separation of clusters. Each cluster is assigned a symbol, and the original signal is replaced by the corresponding sequence of symbols. The symbolization process allows us to shift from the analysis of raw signals to the analysis of sequences of symbols. This discrete representation reduces the amount of data by several orders of magnitude, making the search space for discovering interesting activity more manageable. We describe techniques that operate in this symbolic domain to discover rhythms, transient patterns, abnormal changes in entropy, and clinically significant relationships among multiple streams of physiological data. We tested our techniques on cardiologist-annotated ECG data from forty-eight patients. Our process for labeling heart beats produced results that were consistent with the cardiologist supplied labels 98.6 of the time, and often provided relevant finer-grained distinctions. Our higher level analysis techniques proved effective at identifying clinically relevant activity not only from symbolized ECG streams, but also from multimodal data obtained by symbolizing ECG and other physiological data streams. Using no prior knowledge, our analysis techniques uncovered examples of ventricular bigeminy and trigeminy, ectopic atrial rhythms with aberrant ventricular conduction, paroxysmal atrial tachyarrhythmias, atrial fibrillation, and pulsus paradoxus.

  8. Clustering and Symbolic Analysis of Cardiovascular Signals: Discovery and Visualization of Medically Relevant Patterns in Long-Term Data Using Limited Prior Knowledge

    Directory of Open Access Journals (Sweden)

    Collin Stultz

    2007-01-01

    Full Text Available This paper describes novel fully automated techniques for analyzing large amounts of cardiovascular data. In contrast to traditional medical expert systems our techniques incorporate no a priori knowledge about disease states. This facilitates the discovery of unexpected events. We start by transforming continuous waveform signals into symbolic strings derived directly from the data. Morphological features are used to partition heart beats into clusters by maximizing the dynamic time-warped sequence-aligned separation of clusters. Each cluster is assigned a symbol, and the original signal is replaced by the corresponding sequence of symbols. The symbolization process allows us to shift from the analysis of raw signals to the analysis of sequences of symbols. This discrete representation reduces the amount of data by several orders of magnitude, making the search space for discovering interesting activity more manageable. We describe techniques that operate in this symbolic domain to discover rhythms, transient patterns, abnormal changes in entropy, and clinically significant relationships among multiple streams of physiological data. We tested our techniques on cardiologist-annotated ECG data from forty-eight patients. Our process for labeling heart beats produced results that were consistent with the cardiologist supplied labels 98.6% of the time, and often provided relevant finer-grained distinctions. Our higher level analysis techniques proved effective at identifying clinically relevant activity not only from symbolized ECG streams, but also from multimodal data obtained by symbolizing ECG and other physiological data streams. Using no prior knowledge, our analysis techniques uncovered examples of ventricular bigeminy and trigeminy, ectopic atrial rhythms with aberrant ventricular conduction, paroxysmal atrial tachyarrhythmias, atrial fibrillation, and pulsus paradoxus.

  9. Techniques to Bring Up Mucus

    Science.gov (United States)

    ... Contact Us More COPD: Lifestyle Management Avoiding Infections Breathing Retraining Techniques to Bring Up Mucus Exercises Giving Up Smoking ... mucus is allowed to collect in the airways, breathing may become difficult and infection may occur. Techniques to remove mucus are often done after using ...

  10. Bringing reality into the classroom

    NARCIS (Netherlands)

    A. Heck

    2009-01-01

    Technology offers ample opportunities to bring reality into the classroom. Students and teachers nowadays have many tools to work in an authentic way with real data in mathematics and science education. However, much research and development are still needed to create a consistent learning trajector

  11. Bringing science to the people

    Science.gov (United States)

    This is an opinion editorial piece about the International Society for Horticultural Science (ISHS). It describes the active role that the ISHS takes in bringing scientific information to people throughout the world. The society holds periodic symposia on 10 different crops and 14 different cross-co...

  12. Volatility Discovery

    DEFF Research Database (Denmark)

    Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis

    There is a large literature that investigates how homogenous securities traded on different markets incorporate new information (price discovery analysis). We extend this concept to the stochastic volatility process and investigate how markets contribute to the efficient stochastic volatility whi...

  13. Bringing nursing to the public.

    Science.gov (United States)

    Kazis, Cornelia; Schwendimann, René

    2009-11-01

    For the past 5 years, an unusual program has been evolving in the University of Basel's Institute of Nursing Science master's program in Basel, Switzerland. A special course designed to help nurses master public communication skills requires students to play the roles of journalist, exhibition curator, conference organizer, radio reporter, and news producer. Two faculty members, an experienced radio and newspaper journalist and a nurse scientist, teach and support the students. By developing their competence in media relations, participants prepare themselves to tackle the course's long-term goal of bringing the nursing profession into the public eye. PMID:19731893

  14. BYOD: Bring your own disaster

    CERN Multimedia

    Computer Security Team

    2013-01-01

    Have you ever heard of “BYOD”? No, it is not a pop band. Try again. It is short for “Bring Your Own Device” (the French use “AVEC” -  “Apporter Votre Equipement personnel de Communication”) and describes an option long since offered at CERN: the possibility to bring along your personal laptop, smartphone or PDA, use it on CERN premises and connect it to the CERN office network. But hold on. As practical as it is, there is also a dark side.   The primary advantage, of course, is having a digital work environment tuned to your needs and preferences. It allows you to continue working at home. Similarly, you always have your music, address books and bookmarks with you. However, as valuable as this is, it is also a responsibility. Laptop theft is happening - outside CERN but also on site. In France, 30% of stolen laptops were stolen out of cars or homes, and 10% during travel. At CERN, on average one ...

  15. Beyond Discovery

    DEFF Research Database (Denmark)

    Korsgaard, Steffen; Sassmannshausen, Sean Patrick

    2015-01-01

    as their central concepts and conceptualization of the entrepreneurial function. On this basis we discuss three central themes that cut across the four alternatives: process, uncertainty, and agency. These themes provide new foci for entrepreneurship research and can help to generate new research questions......In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...

  16. Treatment of Noma: medical missions in Ethiopia.

    Science.gov (United States)

    McGurk, M; Marck, R

    2010-02-27

    There is a long tradition in medicine and dentistry to support medical missions in developing countries where health care is limited. These journeys facilitate the spread of knowledge and can be voyages of self-discovery. In the past it has been customary to bring patients to developed countries for treatment. This policy has proved expensive as the medical costs incurred to treat a single patient in the UK can match the cost of sending a ten unit surgical team abroad for two weeks. 50 patients may be treated in this period of time so the pattern of practice is now for teams of healthcare workers to move to areas of need rather than the other way round.

  17. 42 CFR 430.86 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Discovery. 430.86 Section 430.86 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... objection to discovery action initiated under this section. The presiding officer also has the power...

  18. Discovery Mondays

    CERN Document Server

    2003-01-01

    Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...

  19. Amish Lifestyle Brings Unexpected Benefit: Less Asthma

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_160228.html Amish Lifestyle Brings Unexpected Benefit: Less Asthma Finding suggests exposing ... are very similar genetically. They also share many lifestyle factors: low rates of childhood obesity, large family ...

  20. Exercise Brings Bone Benefits that Last

    Science.gov (United States)

    ... Talk Health Capsules Exercise Brings Bone Benefits that Last Paralyzed Men Regain Movement Featured Website: Mental Health Topics Past Issues Most Viewed May 2014 Print RSS Find us on Facebook External link, please review our exit ...

  1. Healthy Family 2009: Bringing in Baby

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Healthy Family 2009 Bringing in Baby Past Issues / Winter 2009 ... Down syndrome and other common genetic disorders, inherited family conditions, such as Duchenne muscular dystrophy, or disorders ...

  2. Zika Infection May Bring Future Immunity

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161496.html Zika Infection May Bring Future Immunity: Study Individuals, and ... HealthDay News) -- People who've been infected with Zika face a low risk for another bout with ...

  3. Bring Your Own Technology (BYOT) to Education

    OpenAIRE

    Joseph M. Woodside; Shahram Amiri

    2014-01-01

    In an effort to reduce costs and increase worker satisfaction, many businesses have implemented a concept known as Bring Your Own Device (BYOD) or Bring Your Own Technology (BYOT). Similarly, many school districts are beginning to implement BYOT policies and programs to improve educational learning opportunities for students who have a wide variety of technology devices. BYOT allow districts with limited budgets enable usage of technology while improving student engagement. This paper explore...

  4. Trends in Modern Drug Discovery.

    Science.gov (United States)

    Eder, Jörg; Herrling, Paul L

    2016-01-01

    Drugs discovered by the pharmaceutical industry over the past 100 years have dramatically changed the practice of medicine and impacted on many aspects of our culture. For many years, drug discovery was a target- and mechanism-agnostic approach that was based on ethnobotanical knowledge often fueled by serendipity. With the advent of modern molecular biology methods and based on knowledge of the human genome, drug discovery has now largely changed into a hypothesis-driven target-based approach, a development which was paralleled by significant environmental changes in the pharmaceutical industry. Laboratories became increasingly computerized and automated, and geographically dispersed research sites are now more and more clustered into large centers to capture technological and biological synergies. Today, academia, the regulatory agencies, and the pharmaceutical industry all contribute to drug discovery, and, in order to translate the basic science into new medical treatments for unmet medical needs, pharmaceutical companies have to have a critical mass of excellent scientists working in many therapeutic fields, disciplines, and technologies. The imperative for the pharmaceutical industry to discover breakthrough medicines is matched by the increasing numbers of first-in-class drugs approved in recent years and reflects the impact of modern drug discovery approaches, technologies, and genomics. PMID:26330257

  5. Trends in Modern Drug Discovery.

    Science.gov (United States)

    Eder, Jörg; Herrling, Paul L

    2016-01-01

    Drugs discovered by the pharmaceutical industry over the past 100 years have dramatically changed the practice of medicine and impacted on many aspects of our culture. For many years, drug discovery was a target- and mechanism-agnostic approach that was based on ethnobotanical knowledge often fueled by serendipity. With the advent of modern molecular biology methods and based on knowledge of the human genome, drug discovery has now largely changed into a hypothesis-driven target-based approach, a development which was paralleled by significant environmental changes in the pharmaceutical industry. Laboratories became increasingly computerized and automated, and geographically dispersed research sites are now more and more clustered into large centers to capture technological and biological synergies. Today, academia, the regulatory agencies, and the pharmaceutical industry all contribute to drug discovery, and, in order to translate the basic science into new medical treatments for unmet medical needs, pharmaceutical companies have to have a critical mass of excellent scientists working in many therapeutic fields, disciplines, and technologies. The imperative for the pharmaceutical industry to discover breakthrough medicines is matched by the increasing numbers of first-in-class drugs approved in recent years and reflects the impact of modern drug discovery approaches, technologies, and genomics.

  6. Bring Your Own Technology (BYOT to Education

    Directory of Open Access Journals (Sweden)

    Joseph M. Woodside

    2014-06-01

    Full Text Available In an effort to reduce costs and increase worker satisfaction, many businesses have implemented a concept known as Bring Your Own Device (BYOD or Bring Your Own Technology (BYOT. Similarly, many school districts are beginning to implement BYOT policies and programs to improve educational learning opportunities for students who have a wide variety of technology devices. BYOT allow districts with limited budgets enable usage of technology while improving student engagement. This paper explores the technology devices, and educational implications of policies, device management, security and included components.

  7. Frontier Fields: A Cost-Effective Approach to Bringing Authentic Science to the Education Community

    Science.gov (United States)

    Eisenhamer, B.; Lawton, B.; Summers, F.; Ryer, H.

    2015-11-01

    For more than two decades, the Hubble EPO program has sought to bring the wonders of the universe to the education community and the public, and to engage audiences in the adventure of scientific discovery. Program components include standards-based, curriculum-support materials, exhibits and exhibit components, and professional development workshops. The main underpinnings of the program's infrastructure are scientist-educator development teams, partnerships, and an embedded program evaluation component. The Space Telescope Science Institute's Office of Public Outreach is leveraging this existing infrastructure to bring the Frontier Fields science program to the education community in a cost-effective way. Frontier Fields observations and results have been, and will continue to be, embedded into existing product lines and professional development offerings. We also are leveraging our new social media strategy to bring the science program to the public in the form of an ongoing blog.

  8. DNA Barcoding Investigations Bring Biology to Life

    Science.gov (United States)

    Musante, Susan

    2010-01-01

    This article describes how DNA barcoding investigations bring biology to life. Biologists recognize the power of DNA barcoding not just to teach biology through connections to the real world but also to immerse students in the exciting process of science. As an investigator in the Program for the Human Environment at Rockefeller University in New…

  9. Bringing Research into Educational Practice: Lessons Learned

    Science.gov (United States)

    Hille, Katrin

    2011-01-01

    Bringing research into educational practice is necessary but does not happen automatically. The Transfercenter for Neuroscience and Learning, at the University of Ulm in Germany, is set up to transfer (neuro)scientific knowledge into educational practice. In doing so we have learned why this does not happen automatically, and have tried to make…

  10. Bringing together the best in Europe

    CERN Multimedia

    Voss, Georgina

    2006-01-01

    With the planned formation of a "European Institute of Technology" announced last week, the EU hopes to bring European innovation and knowledge back into the global picture. The institute, which is planned to be built by 2010, will aim to compete and even rival like institutes in Janpan and the United States (1½ page)

  11. Talent Show Brings Changsha Fame and Fortune

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Super Girl, a TV singing contest,became famous nationwide almost overnight. The show brought Hunan Satellite TV over 100 million yuan(US$12.5 million) last year and is estimated to bring 200 million yuan (US$25 million) of advertising sales to the TV station this year.

  12. Bringing new treatments to the bedside in cystic fibrosis.

    Science.gov (United States)

    Brennan, Amanda L; Geddes, Duncan M

    2004-02-01

    The discovery of the cystic fibrosis transmembrane conductance regulator gene in 1989 led to a dramatic increase in the understanding of the molecular basis of CF. Increased knowledge has provided the opportunity to target drug development at correcting the basic defect either by gene therapy or pharmacological modulation of the abnormal physiological processes. Development of new medications for the CF population poses many challenges. The discovery and development of new medications is always time consuming and expensive. Since CF affects a small population worldwide, the potential for a drug company to profit from a new treatment is limited. In addition, each new therapy must have an additional and proven benefit to be attractive to clinicians and consumers, otherwise it will not be commercially viable. Demonstrating clinical benefit is problematic as a limited number of patients are available to participate in clinical trails and outcome measures, such as length of life, are hard to measure. In this review we will illustrate these challenges by discussing the development of treatments which have successfully reached the bedside and those that were unsuccessful. PMID:14730652

  13. Bringing Breast Cancer Technologies to Market | Poster

    Science.gov (United States)

    CCR research is recognized in novel competition to encourage the commercialization of breast cancer inventions. Editor’s note: This article was originally published in CCR Connections (Volume 8, No. 1). The Breast Cancer Startup Challenge was named one of six finalists in the HHS Innovates Award Competition, and was one of three finalists recognized by HHS Secretary Sylvia Mathews Burwell and Deputy Secretary Bill Corr. For more information on the Challenge, see previous article on the Poster website. Start-up companies are instrumental in bringing the fruits of scientific research to market. Recognizing an opportunity to bring entrepreneurial minds to bear on the diagnosis and treatment of breast cancer, the Avon Foundation for Women partnered with NCI and the Center for Advancing Innovation to launch the Breast Cancer Startup Challenge.

  14. Virtual Waterless Port:" BRING THE PORT FORWARD"

    Institute of Scientific and Technical Information of China (English)

    Wang Siyuan

    2009-01-01

    @@ To deal with the crisis,the central government of China carried out"ten major industries stimulating programme",which includes logistics and information industry.Lifting the development of logistics and information industry to a level of national strategy,it shows that the central governments is paying great attention to construct modern logistics service system,cut the costs and improve efficiency,bringing an opportunity for Chinese logistics industry.

  15. Editorial: Biotechnology Journal brings more than biotechnology.

    Science.gov (United States)

    Jungbauer, Alois; Lee, Sang Yup

    2015-09-01

    Biotechnology Journal always brings the state-of-the-art biotechnologies to our readers. Different from other topical issues, this issue of Biotechnology Journal is complied with a series of exiting reviews and research articles from spontaneous submissions, again, addressing society's actual problems and needs. The progress is a real testimony how biotechnology contributes to achievements in healthcare, better utilization of resources, and a bio-based economy.

  16. Commercializing medical technology

    OpenAIRE

    Scanlon, Kevin J.; Lieberman, Mark A.

    2007-01-01

    As medicine moves into the 21st century, life saving therapies will move from inception into medical products faster if there is a better synergy between science and business. Medicine appears to have 50-year innovative cycles of education and scientific discoveries. In the 1880’s, the chemical industry in Germany was faced with the dilemma of modernization to exploit the new scientific discoveries. The solution was the spawning of novel technical colleges for training in these new chemical i...

  17. Using Multimedia to Bring Science News to the Public

    Science.gov (United States)

    O'Riordan, C.; Stein, B.; Lorditch, E. M.

    2015-12-01

    Creative partnerships between scientists and journalists open new opportunities to bring the excitement of scientific discoveries to wider audiences. Research tells us that the majority of the general public now gets more science and technology news from the Internet than from TV sources (2014 NSF Science and Engineering Indicators). In order to reach these audiences news organizations must embrace multiple forms of multimedia. We will review recent research on how the new multimedia landscape is changing the way that science news is consumed and how news organizations are changing the way they deliver news. News programs like Inside Science, and other examples of new partnerships that deliver research news to journalists, teachers, students, and the general public will be examined. We will describe examples of successful collaborations including an article by a former Newsweek science reporter entitled "My 1975 'Cooling World' Story Doesn't Make Today's Climate Scientists Wrong," which got reprinted in Slate, RealClearScience, and mentioned in Factcheck.org and USA Today.

  18. Penicillin: its discovery and early development.

    Science.gov (United States)

    Ligon, B Lee

    2004-01-01

    In August 1928, Alexander Fleming returned from a vacation to his usually messy, disordered laboratory. In one of the Petri dishes that had not been touched by the Lysol, he noticed an unusual phenomenon: separate colonies of staphylococci and, near the dish's edge, a colony of mold approximately 20 mm in diameter. The finding proved to be a watershed in the history of medicine. This discovery lay dormant for some time before other researchers took up the challenge to investigate its clinical possibilities. Two investigators at Oxford, Sir Howard Walter Florey and Ernst Boris Chain, brought penicillin's potential for medical use to fruition and, along with Fleming, shared the 1945 Nobel Prize for Medicine. The discovery and development of penicillin represent one of the most important developments in the annals of medical history. This article presents a brief overview of the events that occurred in the progress from discovery to implementation as a therapeutic agent. PMID:15175995

  19. Microfluidics for medical applications

    NARCIS (Netherlands)

    Berg, van den Albert; Segerink, Loes

    2015-01-01

    Lab-on-a-chip devices for point of care diagnostics have been present in clinics for several years now. Alongside their continual development, research is underway to bring the organs and tissue on-a-chip to the patient, amongst other medical applications of microfluidics. This book provides the re

  20. Bringing Drumsticks to Funerals. Jamming as Learning

    DEFF Research Database (Denmark)

    Brinck, Lars

    2012-01-01

    musical practices such as jam session is characterized by the iterative discovery of new action possibilities in pursuing a collectively negotiated 'common third': the good music. The study further argues that the musicians’ perpetually changing participation in the jam practice and the development...... of the improvised music itself are inseparable and interdependant. Learning to jam is argued to be situated in the social practice of jamming, thus prototypically presenting learning to be analyzed as improvised development of practice per se. A discussion of the findings' potential for developing teaching...

  1. Computational drug discovery

    Institute of Scientific and Technical Information of China (English)

    Si-sheng OU-YANG; Jun-yan LU; Xiang-qian KONG; Zhong-jie LIANG; Cheng LUO; Hualiang JIANG

    2012-01-01

    Computational drug discovery is an effective strategy for accelerating and economizing drug discovery and development process.Because of the dramatic increase in the availability of biological macromolecule and small molecule information,the applicability of computational drug discovery has been extended and broadly applied to nearly every stage in the drug discovery and development workflow,including target identification and validation,lead discovery and optimization and preclinical tests.Over the past decades,computational drug discovery methods such as molecular docking,pharmacophore modeling and mapping,de novo design,molecular similarity calculation and sequence-based virtual screening have been greatly improved.In this review,we present an overview of these important computational methods,platforms and successful applications in this field.

  2. Reliable knowledge discovery

    CERN Document Server

    Dai, Honghua; Smirnov, Evgueni

    2012-01-01

    Reliable Knowledge Discovery focuses on theory, methods, and techniques for RKDD, a new sub-field of KDD. It studies the theory and methods to assure the reliability and trustworthiness of discovered knowledge and to maintain the stability and consistency of knowledge discovery processes. RKDD has a broad spectrum of applications, especially in critical domains like medicine, finance, and military. Reliable Knowledge Discovery also presents methods and techniques for designing robust knowledge-discovery processes. Approaches to assessing the reliability of the discovered knowledge are introduc

  3. Bringing Pulsed Laser Welding into Production

    DEFF Research Database (Denmark)

    Olsen, Flemmming Ove

    1996-01-01

    production of hermetic weld seams produced on radiator thermostats applying pulsed laser welding. This application has now been running in several years. 2 laser systems are currently welding each serving two welding stations. Another case story is describing a high precision assembly technique of a product......In this paper, some research and develop-ment activities within pulsed laser welding technology at the Tech-nical University of Denmark will be described. The laser group at the Insti-tute for Manufacturing Technology has nearly 20 years of experience in laser materials process-ing. Inter......-nationally the group is mostly known for its contri-butions to the development of the laser cutting process, but further it has been active within laser welding, both in assisting industry in bringing laser welding into production in several cases and in performing fundamental R & D. In this paper some research...

  4. Trying Al Qaeda: Bringing Terrorists to Justice

    Directory of Open Access Journals (Sweden)

    Joshua T. Bell

    2010-11-01

    Full Text Available Shortly after the World Trade Center and the Pentagon were attacked, the United States embarked on a mission to bring those responsible for the terrorist attacks on 11 September 2001 to justice. A tremendous effort ensued to find and capture the individuals who were responsible or associated with these events. Many of the individuals who were captured have remained imprisoned for an indefinite amount of time due to the political debate regarding what is the most appropriate venue to try suspecgts arrested and charged with acts of terrorism. The choices come down to trial either by a trial by a Military Commission or a U.S. Federal District Court. There are unique challenges for effective prosecution in both venues. Which venue the Obama Administration will deem appropriate to try the terrorists captured by the former administration remains uncertain at this point in time.

  5. Higgs Discovery Movie

    CERN Multimedia

    2014-01-01

    The ATLAS & CMS Experiments Celebrate the 2nd Anniversary of the Discovery of the Higgs boson. Here, are some images of the path from LHC startup to Nobel Prize, featuring a musical composition by Roger Zare, performed by the Donald Sinta Quartet, called “LHC”. Happy Discovery Day!

  6. Decades of Discovery

    Science.gov (United States)

    2011-06-01

    For the past two-and-a-half decades, the Office of Science at the U.S. Department of Energy has been at the forefront of scientific discovery. Over 100 important discoveries supported by the Office of Science are represented in this document.

  7. Academic Drug Discovery Centres

    DEFF Research Database (Denmark)

    Kirkegaard, Henriette Schultz; Valentin, Finn

    2014-01-01

    Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...

  8. Service discovery at home

    NARCIS (Netherlands)

    Sundramoorthy, Vasughi; Scholten, Hans; Jansen, Pierre; Hartel, Pieter

    2003-01-01

    Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several promin

  9. Bringing Seismological Research into the School Setting

    Science.gov (United States)

    Pavlis, G. L.; Hamburger, M. W.

    2004-12-01

    One of the primary goals of educational seismology programs is to bring inquiry-based research to the middle- and high-school classroom setting. Although it is often stated as a long-term goal of science outreach programs, in practice there are many barriers to research in the school setting, among them increasing emphasis on test-oriented training, decreasing interest and participation in science fairs, limited teacher confidence and experience for mentoring research, insufficient student preparedness for research projects, and the short term of university involvement (typically limited to brief one-day encounters). For the past three+ years we have tried to address these issues through a focused outreach program we have called the PEPP Research Fellows Program. This is treated as an honors program in which high school teachers in our group nominate students with interests in science careers. These students are invited to participate in the program, and those who elect to take part participate in a one-day education and training session in the fall. Rather than leave research projects completely open, we direct the students at toward one of two specific, group-oriented projects (in our case, one focusing on local recordings of mining explosions, and a second on teleseismic body-wave analysis), but we encourage them to act as independent researchers and follow topics of interest. The students then work on seismic data from the local educational network or from the IRIS facilities. Following several months of informal interaction with teachers and students (email, web conferencing, etc.), we bring the students and teachers to our university for a weekend research symposium in the spring. Students present their work in oral or poster form and prizes are given for the best papers. Projects range from highly local projects (records of seismic noise at school X) to larger-scale regional projects (analysis of teleseismic P-wave delays at PEPP network stations) From 20 to

  10. Poster power brings together electronics community

    CERN Multimedia

    2006-01-01

    An 'Electronics at CERN' poster session was displayed on the mezzanine in building 500 for two days from 30 November. The display consisted of 20 posters and brought together a wide range of electronic projects designed and assembled by CERN teams and other collaborators involved in the building of the LHC. This was the first time this event had been held. As its organiser John Evans (IT/DES) explained, 'the idea came from the experience of attending conferences outside CERN, where you may find projects from CERN you didn't know about. It's nice to bring them together so we can all benefit from the efforts made.' The work on show spanned different departments and experiments, ranging from microelectronics to equipment designed for giant magnets. The invited audience was equally broad and included engineers, physicists as well as the electronics community at CERN. An informal gathering of all the exhibitors also offered an opportunity to view and discuss the work over a cup of coffee. 'The poster session acts...

  11. Bringing Reflections into the TEFL Classrooms

    Directory of Open Access Journals (Sweden)

    M Sri Samiati Tarjana

    2002-01-01

    Full Text Available Abstract: Reflective practice is defined by John Dewey as a proactive, ongoing examination of beliefs and practices, their origins and impacts. In the reflective practice, the teacher and learners are engaged in a continuous cycle of self-observation and self-evaluation in order to understand their own actions and reactions, and thereby develop the teaching-learning process on an on-going basis. While English is regarded as compulsory in the preparation of more qualified human resources for the country, there are still complaints about the low English mastery of the majority of secondary and tertiary education graduates in Indonesia. It seems likely that bringing the reflective practice in the TEFL classrooms will help improve the teaching-learning of English in a more caring and responsive manner. It is expected that this will not only improve the English mastery, but also develop personal talents and capacities of the learners. The features of reflective practice in TEFL and their advantages for personal and professional development will be further discussed.

  12. Bringing science to the policy table

    CERN Multimedia

    2014-01-01

    “They shall beat their swords into plowshares, and their spears into pruning hooks. Nation shall not lift up sword against nation. Neither shall they learn war anymore." So says Isaiah 2:4, as transcribed on the famous wall in Ralph Bunche park, just the other side of 1st Avenue from the UN’s New York headquarters, where we held a celebration of our 60th anniversary year on Monday 20 October. I used the quotation in my opening address, since it is such a perfect fit to the theme of 60 years of science for peace and development.   The event was organised with the United Nations Economic and Social Council, ECOSOC, in the framework of CERN’s observer status at the UN, and although focused on CERN, its aim was broader. Presentations used CERN as an example to bring out the vital importance of science in general to the themes of peace and development. The event was presided over by Martin Sajdik, President of ECOSOC, and we were privileged to have presentat...

  13. Medical robotics.

    Science.gov (United States)

    Ferrigno, Giancarlo; Baroni, Guido; Casolo, Federico; De Momi, Elena; Gini, Giuseppina; Matteucci, Matteo; Pedrocchi, Alessandra

    2011-01-01

    Information and communication technology (ICT) and mechatronics play a basic role in medical robotics and computer-aided therapy. In the last three decades, in fact, ICT technology has strongly entered the health-care field, bringing in new techniques to support therapy and rehabilitation. In this frame, medical robotics is an expansion of the service and professional robotics as well as other technologies, as surgical navigation has been introduced especially in minimally invasive surgery. Localization systems also provide treatments in radiotherapy and radiosurgery with high precision. Virtual or augmented reality plays a role for both surgical training and planning and for safe rehabilitation in the first stage of the recovery from neurological diseases. Also, in the chronic phase of motor diseases, robotics helps with special assistive devices and prostheses. Although, in the past, the actual need and advantage of navigation, localization, and robotics in surgery and therapy has been in doubt, today, the availability of better hardware (e.g., microrobots) and more sophisticated algorithms(e.g., machine learning and other cognitive approaches)has largely increased the field of applications of these technologies,making it more likely that, in the near future, their presence will be dramatically increased, taking advantage of the generational change of the end users and the increasing request of quality in health-care delivery and management.

  14. LHC card games: bringing about retrocausality?

    CERN Document Server

    Silagadze, Z K

    2010-01-01

    The model of Nielsen and Ninomiya claims that "the SSC (Superconducting Supercollider) were stopped by the US Congress due to the backward causation from the big amounts of Higgs particles, which it would have produced, if it had been allowed to run". They also proposed to play a card game and if the "close LHC" card is drawn (with probability $\\sim 10^{-6}$), really close LHC on the eve of Higgs particle discovery to avoid more severe bad luck. Crazy? Probably. But paraphrasing Salvador Dali, if you believe that you and me are smarter in physics than Nielsen and Ninomiya, don't read this article, just go right on in your blissful idiocy. Therefore, I will try to make sense of backward causation. It turns out that not only the backward causation makes perfect sense in some models of possible reality, but that Nielsen and Ninomiya really have a chance to close LHC by a card game. The only thing they need is to be smart enough to manage to develop their theory up to the level of brilliance beginning from which ...

  15. The Greatest Mathematical Discovery?

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, Jonathan M.

    2010-05-12

    What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.

  16. Integrated system brings hospital data together.

    Science.gov (United States)

    Johnson, K F

    1987-10-01

    Healthcare industry changes during the 1980s--increased competition and alterations in the Medicare payment methodology--place new and more complex demands on a hospital's information systems, which often fall short of meeting those demands. These systems were designed for financial reporting, billing, or providing clinical data, and few of them are capable of linking with other unrelated systems. Today's hospital manager needs timely and simultaneous access to data from a variety of sources within the hospital. All the elements to accomplish this are collected somewhere in the hospital, but finding them and bringing them together is difficult. The key to the efficient management and use of data bases is in understanding the fundamental concept of relational data bases, which is the capability of linking or joining separate data files through a common data element in each file. In this way, data files may be integrated into a "related" data base. Any number of separate files, or tables, may exist within a "relational" data base as long as a series of threads links them. A strategic management information data base includes the information necessary to analyze, understand, and manage the hospital's markets, products, resources, and profitability. The major components of this information system are the case mix and cost accounting, budgeting, and modeling systems. The case mix and cost accounting factors involve managing concrete pieces of data, whereas the budgeting and modeling factors manipulate data to create a scenario. The strategic management information data base is the foundation of a hospital's decision support system, which is rapidly moving into the category of a necessary tool of the hospital manager's trade.

  17. Bringing the Unidata IDV to the Cloud

    Science.gov (United States)

    Fisher, W. I.; Oxelson Ganter, J.

    2015-12-01

    Maintaining software compatibility across new computing environments and the associated underlying hardware is a common problem for software engineers and scientific programmers. While traditional software engineering provides a suite of tools and methodologies which may mitigate this issue, they are typically ignored by developers lacking a background in software engineering. Causing further problems, these methodologies are best applied at the start of project; trying to apply them to an existing, mature project can require an immense effort. Visualization software is particularly vulnerable to this problem, given the inherent dependency on particular graphics hardware and software API's. As a result of these issues, there exists a large body of software which is simultaneously critical to the scientists who are dependent upon it, and yet increasingly difficult to maintain.The solution to this problem was partially provided with the advent of Cloud Computing; Application Streaming. This technology allows a program to run entirely on a remote virtual machine while still allowing for interactivity and dynamic visualizations, with little-to-no re-engineering required. When coupled with containerization technology such as Docker, we are able to easily bring the same visualization software to a desktop, a netbook, a smartphone, and the next generation of hardware, whatever it may be.Unidata has been able to harness Application Streaming to provide a tablet-compatible version of our visualization software, the Integrated Data Viewer (IDV). This work will examine the challenges associated with adapting the IDV to an application streaming platform, and include a brief discussion of the underlying technologies involved.

  18. Toxins and drug discovery.

    Science.gov (United States)

    Harvey, Alan L

    2014-12-15

    Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. PMID:25448391

  19. Leadership and Discovery

    CERN Document Server

    Goethals, George R

    2009-01-01

    This book, a collection of essays from scholars across disciplines, explores leadership of discovery, probing the guided and collaborative exploration and interpretation of the experience of our inner thoughts and feelings, and of our external worlds

  20. Fateful discovery almost forgotten

    CERN Multimedia

    1989-01-01

    "The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)

  1. Discovery Driven Growth

    DEFF Research Database (Denmark)

    Bukh, Per Nikolaj

    2009-01-01

    Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...

  2. Discovery in a World of Mashups

    Science.gov (United States)

    King, T. A.; Ritschel, B.; Hourcle, J. A.; Moon, I. S.

    2014-12-01

    When the first digital information was stored electronically, discovery of what existed was through file names and the organization of the file system. With the advent of networks, digital information was shared on a wider scale, but discovery remained based on file and folder names. With a growing number of information sources, named based discovery quickly became ineffective. The keyword based search engine was one of the first types of a mashup in the world of Web 1.0. Embedded links from one document to another with prescribed relationships between files and the world of Web 2.0 was formed. Search engines like Google used the links to improve search results and a worldwide mashup was formed. While a vast improvement, the need for semantic (meaning rich) discovery was clear, especially for the discovery of scientific data. In response, every science discipline defined schemas to describe their type of data. Some core schemas where shared, but most schemas are custom tailored even though they share many common concepts. As with the networking of information sources, science increasingly relies on data from multiple disciplines. So there is a need to bring together multiple sources of semantically rich information. We explore how harvesting, conceptual mapping, facet based search engines, search term promotion, and style sheets can be combined to create the next generation of mashups in the emerging world of Web 3.0. We use NASA's Planetary Data System and NASA's Heliophysics Data Environment to illustrate how to create a multi-discipline mash-up.

  3. Smart Technology Brings Power to the People

    Energy Technology Data Exchange (ETDEWEB)

    Hammerstrom, Donald J.; Gephart, Julie M.

    2006-12-01

    Imagine you’re at home one Saturday morning on the computer, as your son takes a shower, your daughter is watching TV, and a load of laundry is in your washer and dryer. Meanwhile, the fragrance of fresh-brewed coffee fills the house. You hear a momentary beep from the dryer that tells you that if you were to look, a high-energy price indicator would be displayed on the front panels of some of your favorite appliances. This tells you that you could save money right now by using less energy. (You’ve agreed to this arrangement to help your utility avoid a substation upgrade. In return, you get a lower rate most of the time.) So you turn off some of the unneeded lights in your home and opt to wait until evening to run the dishwasher. Meanwhile, some of your largest appliances have automatically responded to this signal and have already reduced your home’s energy consumption, saving you money. On January 11, 2006, demonstration projects were launched in 200 homes in the Pacific Northwest region of the United States to test and speed adoption of new smart grid technologies that can make the power grid more resilient and efficient. Pacific Northwest National Laboratory, a U.S. Department of Energy national laboratory in Richland, Washington, is managing the yearlong study called the Pacific Northwest GridWise™ Testbed Demonstration, a project funded primarily by DOE. Through the GridWise™ Demonstration projects, researchers are gaining insight into energy consumers’ behavior while testing new technologies designed to bring the electric transmission system into the information age. Northwest utilities, appliance manufacturers and technology companies are also supporting this effort to demonstrate the devices and assess the resulting consumer response. A combination of devices, software and advanced analytical tools will give homeowners more information about their energy use and cost, and we want to know if this will modify their behavior. Approximately 100

  4. Bringing Science out of the Lab into the Classroom

    Science.gov (United States)

    2006-03-01

    Science is moving more rapidly than ever; one groundbreaking discovery chases the next at an incredible speed. School teachers have trouble keeping up with the pace, and many pupils call science classes "boring". Today, Europe's major research organisations launch Science in School, the first international, multidisciplinary journal for innovative science teaching, to provide a platform for communication between science teachers, practising scientists and other stakeholders in science education. ESO PR Photo 12/06 ESO PR Photo 12/06 First Issue! "Science is becoming increasingly international and interdisciplinary," says Eleanor Hayes, editor of the journal. "The most exciting development of the day may happen anywhere in any field: students may suddenly want to talk about a discovery on Mars, a medical breakthrough or a natural disaster. On such days it would be a shame not to put the textbooks aside and to capitalise on that curiosity." Published by EIROforum, a partnership between Europe's seven largest intergovernmental research organisations, Science in School will bridge the gap between the worlds of research and schools. One extremely powerful tool to achieve this is the journal's web-based discussion forum that will establish a direct dialogue between science teachers and researchers across national and subject boundaries. Science in School will appear quarterly online and in print and will feature news about the latest scientific discoveries, teaching materials, interviews with inspiring teachers and scientists, reviews of books, films and websites, suggestions for class trips, training opportunities and many other useful resources for science teachers. Contributors to the first issue include the world-renowned neurologist and author Oliver Sachs, and scientists and teachers from nine countries. "We urgently need to engage young people in science. This is why the research community and the European Commission are committed to outreach and education

  5. A Decade of Discovery

    Energy Technology Data Exchange (ETDEWEB)

    None

    2008-01-01

    This book provides a fascinating account of some of the most significant scientific discoveries and technological innovations coming out of the U.S. Department of Energy’s National Laboratories. This remarkable book illustrates how the men and women of the National Laboratories are keeping us on the cutting edge. Though few Americans are familiar with the scope and scale of the work conducted at these National Laboratories, their research is literally changing our lives and bettering our planet. The book describes the scientific discoveries and technological advancements "in recognition of the men and women working in DOE's seventeen national laboratories across the country." Through highly vivid and accessible stories, this book details recent breakthroughs in three critical areas: 1) Energy and Environment, 2) National Security and 3) Life and Physical Science. The book illustrates how this government-funded research has resulted in more energy-efficient buildings; new, cleaner alternative fuels that reduce greenhouse gas emissions; safer, more efficient, nuclear power plants; improved responses to disease outbreaks; more secure and streamlined airport security; more effective treatments for cancer and other diseases; and astonishing discoveries that are altering our understanding of the universe and enabling scientific breakthroughs in fields such as nanotechnology and particle physics. Specifically, it contains 37 stories. A Decade of Discovery is truly a recent history of discovery - and a fascinating look at what the next decade holds.

  6. From the Moon: Bringing Space Science to Diverse Audiences

    Science.gov (United States)

    Runyon, C. J.; Hall, C.; Joyner, E.; Meyer, H. M.; M3 Science; E/PO Team

    2011-12-01

    NASA's Apollo missions held a place in the mindset of many Americans - we dared to go someplace where humans had never set foot, a place unknown and beyond our imaginations. These early NASA missions and discoveries resulted in an enhanced public understanding of the Moon. Now, with the human element so far removed from space exploration, students must rely on textbooks, TV's, and computers to build their understanding of our Moon. However, NASA educational materials about the Moon are stale and out-of-date. In addition, they do not effectively address 21st Century Skills, an essential for today's classrooms. Here, we present a three-part model for developing opportunities in lunar science education professional development that is replicable and sustainable and integrates NASA mission-derived data (e.g., Moon Mineralogy Mapper (M3)/Chandrayaan-1). I) With the return of high resolution/high spatial data from M3/Chandrayaan-1, we can now better explore and understand the compositional variations on the lunar surface. Data and analysis techniques from the imaging spectrometer are incorporated into the M3 Educator's Guide: Seeing the Moon in a New Light. The guide includes an array of activities and lessons to help educators and students understand how NASA is currently exploring the Moon. The guide integrates NASA maps and data into the interactive lessons, bringing the excitement of scientific exploration and discovery into the classroom. II) Utilizing the M3 Educator's Guide as well as educational activities from more current NASA lunar missions, we offer two sustained professional development opportunities for educators to explore the Moon through interactive and creative strategies. 1) Geology of the Moon, an online course offered through Montana State University's National Teacher Enhancement Network, is a 3-credit graduate course. 2) Fly Me to the Moon, offered through the College of Charleston's Office of Professional Development in Education, is a two

  7. Bring out your codes! Bring out your codes! (Increasing Software Visibility and Re-use)

    Science.gov (United States)

    Allen, A.; Berriman, B.; Brunner, R.; Burger, D.; DuPrie, K.; Hanisch, R. J.; Mann, R.; Mink, J.; Sandin, C.; Shortridge, K.; Teuben, P.

    2013-10-01

    Progress is being made in code discoverability and preservation, but as discussed at ADASS XXI, many codes still remain hidden from public view. With the Astrophysics Source Code Library (ASCL) now indexed by the SAO/NASA Astrophysics Data System (ADS), the introduction of a new journal, Astronomy & Computing, focused on astrophysics software, and the increasing success of education efforts such as Software Carpentry and SciCoder, the community has the opportunity to set a higher standard for its science by encouraging the release of software for examination and possible reuse. We assembled representatives of the community to present issues inhibiting code release and sought suggestions for tackling these factors. The session began with brief statements by panelists; the floor was then opened for discussion and ideas. Comments covered a diverse range of related topics and points of view, with apparent support for the propositions that algorithms should be readily available, code used to produce published scientific results should be made available, and there should be discovery mechanisms to allow these to be found easily. With increased use of resources such as GitHub (for code availability), ASCL (for code discovery), and a stated strong preference from the new journal Astronomy & Computing for code release, we expect to see additional progress over the next few years.

  8. Stress and mental health among medical students

    OpenAIRE

    Backović Dušan V.; Maksimović Miloš; Davidović Dragana; Ilić-Živojinović Jelena; Stevanović Dejan

    2013-01-01

    Introduction. Medical studies bring many stressful activities to students. Prolonged stress can make adverse effects to mental health and lead to further professional burnout. Objective. The aim of this study was to assess the association of stress impact and adverse effects of medical studies with psychological distress among medical students. Methods. The cross sectional study was conducted on 367 fourth­year medical students of the Faculty of Medicine in...

  9. Knowledge Discovery from Biomedical Ontologies in Cross Domains.

    Science.gov (United States)

    Shen, Feichen; Lee, Yugyung

    2016-01-01

    In recent years, there is an increasing demand for sharing and integration of medical data in biomedical research. In order to improve a health care system, it is required to support the integration of data by facilitating semantic interoperability systems and practices. Semantic interoperability is difficult to achieve in these systems as the conceptual models underlying datasets are not fully exploited. In this paper, we propose a semantic framework, called Medical Knowledge Discovery and Data Mining (MedKDD), that aims to build a topic hierarchy and serve the semantic interoperability between different ontologies. For the purpose, we fully focus on the discovery of semantic patterns about the association of relations in the heterogeneous information network representing different types of objects and relationships in multiple biological ontologies and the creation of a topic hierarchy through the analysis of the discovered patterns. These patterns are used to cluster heterogeneous information networks into a set of smaller topic graphs in a hierarchical manner and then to conduct cross domain knowledge discovery from the multiple biological ontologies. Thus, patterns made a greater contribution in the knowledge discovery across multiple ontologies. We have demonstrated the cross domain knowledge discovery in the MedKDD framework using a case study with 9 primary biological ontologies from Bio2RDF and compared it with the cross domain query processing approach, namely SLAP. We have confirmed the effectiveness of the MedKDD framework in knowledge discovery from multiple medical ontologies.

  10. Knowledge Discovery from Biomedical Ontologies in Cross Domains

    Science.gov (United States)

    Shen, Feichen; Lee, Yugyung

    2016-01-01

    In recent years, there is an increasing demand for sharing and integration of medical data in biomedical research. In order to improve a health care system, it is required to support the integration of data by facilitating semantic interoperability systems and practices. Semantic interoperability is difficult to achieve in these systems as the conceptual models underlying datasets are not fully exploited. In this paper, we propose a semantic framework, called Medical Knowledge Discovery and Data Mining (MedKDD), that aims to build a topic hierarchy and serve the semantic interoperability between different ontologies. For the purpose, we fully focus on the discovery of semantic patterns about the association of relations in the heterogeneous information network representing different types of objects and relationships in multiple biological ontologies and the creation of a topic hierarchy through the analysis of the discovered patterns. These patterns are used to cluster heterogeneous information networks into a set of smaller topic graphs in a hierarchical manner and then to conduct cross domain knowledge discovery from the multiple biological ontologies. Thus, patterns made a greater contribution in the knowledge discovery across multiple ontologies. We have demonstrated the cross domain knowledge discovery in the MedKDD framework using a case study with 9 primary biological ontologies from Bio2RDF and compared it with the cross domain query processing approach, namely SLAP. We have confirmed the effectiveness of the MedKDD framework in knowledge discovery from multiple medical ontologies. PMID:27548262

  11. Physics instrumentation for medical imaging

    International Nuclear Information System (INIS)

    The first Nobel Physics Prize, awarded in 1901, went to Wilhelm Röntgen for his discovery of X-rays in 1895. This, and the most recent physics Nobel, to Georges Charpak last year for his detector developments, span several generations of applied science. As well as helping to launch the science of atomic physics, Röntgen's discovery also marked the dawn of a medical science - radiography - using beams of various kinds to image what otherwise cannot be seen. Ever since, physicists and radiologists have worked hand in hand to improve imaging techniques and widen their medical applications

  12. Evaluating ten discoveries

    Energy Technology Data Exchange (ETDEWEB)

    1973-02-01

    Mexico's state company, Pemex, announces 10 significant oil and gas discoveries in the states of Tamaulipas and Chiapas. Most promising finds are a new oil province in S. Mexico and a deeper pool strike at the offshore Arenque field. The latter seems to point to the existence of an attractive reefal trend extending on shore toward the State of Nuevo Leon.

  13. Discovery of TUG-770

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth; Hansen, Steffen V F; Urban, Christian;

    2013-01-01

    Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical...

  14. Archaeological Discoveries in Liaoning

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    LIAONING Province, in northeastern China, has been inhabited by many ethnic groups since ancient times. It is one of the sites of China’s earliest civilization. Since the 1950s many archaeological discoveries from periods beginning with the Paleolithic of 200,000 years ago, and through all the following historic periods, have been made in the province.

  15. Beacons of discovery the worldwide science of particle physics

    CERN Document Server

    International Committee for Future Accelerators (ICFA)

    2011-01-01

    To discover what our world is made of and how it works at the most fundamental level is the challenge of particle physics. The tools of particle physics—experiments at particle accelerators and underground laboratories, together with observations of space—bring opportunities for discovery never before within reach. Thousands of scientists from universities and laboratories around the world collaborate to design, build and use unique detectors and accelerators to explore the fundamental physics of matter, energy, space and time. Together, in a common world-wide program of discovery, they provide a deep understanding of the world around us and countless benefits to society. Beacons of Discovery presents a vision of the global science of particle physics at the dawn of a new light on the mystery and beauty of the universe.

  16. Bring your own device (BYOD) to work trend report

    CERN Document Server

    Hayes, Bob

    2013-01-01

    Bring Your Own Device (BYOD) to Work examines the emerging BYOD (Bring Your Own Device to work) trend in corporate IT. BYOD is the practice of employees bringing personally-owned mobile devices (e.g., smartphones, tablets, laptops) to the workplace, and using those devices to access company resources such as email, file servers, and databases. BYOD presents unique challenges in data privacy, confidentiality, security, productivity, and acceptable use that must be met proactively by information security professionals. This report provides solid background on the practice, original res

  17. COPD Discovery Might Improve Treatment

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_158852.html COPD Discovery Might Improve Treatment Study may help pinpoint ... will progress, a discovery they believe could improve COPD treatment. Their research might help doctors determine which ...

  18. Creating A Guided- discovery Lesson

    Institute of Scientific and Technical Information of China (English)

    田枫

    2005-01-01

    In a guided - discovery lesson, students sequentially uncover layers of mathematical information one step at a time and learn new mathematics. We have identified eight critical steps necessary in developing a successful guided- discovery lesson.

  19. STS-114: Discovery Launch Readiness Press Conference

    Science.gov (United States)

    2005-01-01

    Michael Griffin, NASA Administrator; Wayne Hale, Space Shuttle Deputy Program Manager; Mike Wetmore, Director of Shuttle Processing; and 1st Lieutenant Mindy Chavez, Launch Weather Officer-United States Air Force 45th Weather Squadron are in attendance for this STS-114 Discovery launch readiness press conference. The discussion begins with Wayne Hale bringing to the table a low level sensor device for everyone to view. He talks in detail about all of the extensive tests that were performed on these sensors and the completion of these ambient tests. Chavez presents her weather forecast for the launch day of July 26th 2005. Michael Griffin and Wayne Hale answer questions from the news media pertaining to the sensors and launch readiness. The video ends with footage of Pilot Jim Kelly and Commander Eileen Collins conducting test flights in a Shuttle Training Aircraft (STA) that simulates Space Shuttle landing.

  20. Translating Stem Cell Biology Into Drug Discovery

    Science.gov (United States)

    Singeç, Ilyas; Simeonov, Anton

    2016-01-01

    Pluripotent stem cell research has made extraordinary progress over the last decade. The robustness of nuclear reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has created entirely novel opportunities for drug discovery and personalized regenerative medicine. Patient- and disease-specific iPSCs can be expanded indefinitely and differentiated into relevant cell types of different organ systems. As the utilization of iPSCs is becoming a key enabling technology across various scientific disciplines, there are still important challenges that need to be addressed. Here we review the current state and reflect on the issues that the stem cell and translational communities are facing in bringing iPSCs closer to clinical application.

  1. Data Warehouse Discovery Framework: The Foundation

    Science.gov (United States)

    Apanowicz, Cas

    The cost of building an Enterprise Data Warehouse Environment runs usually in millions of dollars and takes years to complete. The cost, as big as it is, is not the primary problem for a given corporation. The risk that all money allocated for planning, design and implementation of the Data Warehouse and Business Intelligence Environment may not bring the result expected, fare out way the cost of entire effort [2,10]. The combination of the two above factors is the main reason that Data Warehouse/Business Intelligence is often single most expensive and most risky IT endeavor for companies [13]. That situation was the main author's inspiration behind founding of Infobright Corp and later on the concept of Data Warehouse Discovery Framework.

  2. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia

    1999-01-01

    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  3. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia

    1997-01-01

    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  4. Major Ups and Downs: Bipolar Disorder Brings Extreme Mood Swings

    Science.gov (United States)

    ... our exit disclaimer . Subscribe Major Ups and Downs Bipolar Disorder Brings Extreme Mood Swings Most people feel happy ... Strike Out Stroke Wise Choices Links Dealing with Bipolar Disorder If you have bipolar disorder, get treatment and ...

  5. Climate Change May Bring More Tainted Shellfish to Northern Seas

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160300.html Climate Change May Bring More Tainted Shellfish to Northern Seas ... must be monitored "in the light of ongoing climate change, especially in coastal areas most heavily affected by ...

  6. Bringing History Home. Postcolonial Immigrants and the Dutch Cultural Arena

    OpenAIRE

    Legêne, S.

    2011-01-01

    Bringing History Home: Postcolonial Immigrants and the Dutch Cultural ArenaThree Dutch-language monographs published in 2008-2009 by Ulbe Bosma, Lizzy van Leeuwen and Gert Oostindie in the context of the interdisciplinary research programme Bringing History Home, present a history of identity politics in relation to ‘postcolonial immigrants’. This term refers to some 500,000 people who since 1945 arrived in the Netherlands from Indonesia and the former Dutch New Guinea, Suriname or the Antill...

  7. Atlas of Astronomical Discoveries

    CERN Document Server

    Schilling, Govert

    2011-01-01

    Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...

  8. The discovery of quarks.

    Science.gov (United States)

    Riordan, M

    1992-05-29

    Quarks are widely recognized today as being among the elementary particles of which matter is composed. The key evidence for their existence came from a series of inelastic electron-nucleon scattering experiments conducted between 1967 and 1973 at the Stanford Linear Accelerator Center. Other theoretical and experimental advances of the 1970s confirmed this discovery, leading to the present standard model of elementary particle physics.

  9. Opportunistic Adaptation Knowledge Discovery

    OpenAIRE

    Badra, Fadi; Cordier, Amélie; Lieber, Jean

    2009-01-01

    The original publication is available at www.springerlink.com International audience Adaptation has long been considered as the Achilles' heel of case-based reasoning since it requires some domain-specific knowledge that is difficult to acquire. In this paper, two strategies are combined in order to reduce the knowledge engineering cost induced by the adaptation knowledge (CA) acquisition task: CA is learned from the case base by the means of knowledge discovery techniques, and the CA a...

  10. Discovery with FAST

    Science.gov (United States)

    Wilkinson, P.

    2016-02-01

    FAST offers "transformational" performance well-suited to finding new phenomena - one of which might be polarised spectral transients. But discoveries will only be made if "the system" provides its users with the necessary opportunities. In addition to designing in as much observational flexibility as possible, FAST should be operated with a philosophy which maximises its "human bandwidth". This band includes the astronomers of tomorrow - many of whom not have yet started school or even been born.

  11. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  12. Mental and Medical sciences today

    OpenAIRE

    David L. Rowland; Ion G. Motofei

    2014-01-01

    Journal of Mind and Medical Sciences is designed as a free online, open access, interdisciplinary and peer-reviewed journal. The JMMS mission is to address ideas and issues related to mind and medicine, publishing scientific review and empirical papers regarding mental and medical health and disease. Our goal is to stimulate constructive debates among scholars, researchers, physicians, scientists and health professionals with respect to the latest discoveries and trends in the field. The jour...

  13. Mathematical models in biological discovery

    CERN Document Server

    Walter, Charles

    1977-01-01

    When I was asked to help organize an American Association for the Advancement of Science symposium about how mathematical models have con­ tributed to biology, I agreed immediately. The subject is of immense importance and wide-spread interest. However, too often it is discussed in biologically sterile environments by "mutual admiration society" groups of "theoreticians", many of whom have never seen, and most of whom have never done, an original scientific experiment with the biolog­ ical materials they attempt to describe in abstract (and often prejudiced) terms. The opportunity to address the topic during an annual meeting of the AAAS was irresistable. In order to try to maintain the integrity ;,f the original intent of the symposium, it was entitled, "Contributions of Mathematical Models to Biological Discovery". This symposium was organized by Daniel Solomon and myself, held during the 141st annual meeting of the AAAS in New York during January, 1975, sponsored by sections G and N (Biological and Medic...

  14. Advances in Chance Discovery : Extended Selection from International Workshops

    CERN Document Server

    Abe, Akinori

    2013-01-01

    Since year 2000, scientists on artificial and natural intelligences started to study chance discovery - methods for discovering events/situations that significantly affect decision making. Partially because the editors Ohsawa and Abe are teaching at schools of Engineering and of Literature with sharing the interest in chance discovery, this book reflects interdisciplinary aspects of progress: First, as an interdisciplinary melting pot of cognitive science, computational intelligence, data mining/visualization, collective intelligence, … etc, chance discovery came to reach new application domains e.g. health care, aircraft control, energy plant, management of technologies, product designs, innovations, marketing, finance etc. Second, basic technologies and sciences including sensor technologies, medical sciences, communication technologies etc. joined this field and interacted with cognitive/computational scientists in workshops on chance discovery, to obtain breakthroughs by stimulating each other. Third, �...

  15. Knowledge Discovery in Textual Documentation: Qualitative and Quantitative Analyses.

    Science.gov (United States)

    Loh, Stanley; De Oliveira, Jose Palazzo M.; Gastal, Fabio Leite

    2001-01-01

    Presents an application of knowledge discovery in texts (KDT) concerning medical records of a psychiatric hospital. The approach helps physicians to extract knowledge about patients and diseases that may be used for epidemiological studies, for training professionals, and to support physicians to diagnose and evaluate diseases. (Author/AEF)

  16. Marie and Pierre Curie and radium: history, mystery, and discovery.

    Science.gov (United States)

    Mould, R F

    1999-09-01

    Commencing with Marie Curie's early life in Poland and the discovery of radium in the rue l'Homond "shed" in Paris in 1898, this paper includes some little known facts. It ends with some unusual uses of and claims for radium, and finally, because Medical Physics is an American journal, details are included of Marie Curie's two visits to the USA.

  17. Literature-related discovery techniques applied to ocular disease : a vitreous restoration example

    NARCIS (Netherlands)

    Kostoff, Ronald N.; Los, Leonoor I.

    2013-01-01

    Purpose of reviewLiterature-related discovery and innovation (LRDI) is a text mining approach for bridging unconnected disciplines to hypothesize radical discovery. Application to medical problems involves identifying key disease symptoms, and identifying causes and treatments for those symptoms fro

  18. Discovery – Cisplatin and The Treatment of Testicular and Other Cancers

    Science.gov (United States)

    Prior to the discovery of cisplatin in 1965, men with testicular cancer had few medical options. Now, thanks to NCI research, cisplatin and similar chemotherapy drugs are known for curing testicular and other forms of cancer.

  19. Ototoxic Medications (Medication Effects)

    Science.gov (United States)

    ... effects of the medications on your hearing and balance systems. The team will discuss with you how these side effects will affect your quality of life. What are the effects I may notice from ... speech is affected. Balance problems can also occur as a result of ...

  20. Abortion - medical

    Science.gov (United States)

    Therapeutic medical abortion; Elective medical abortion; Induced abortion; Nonsurgical abortion ... A medical, or nonsurgical, abortion can be done within 7 weeks from the first day of the woman's last ...

  1. Discovery Mondays - 'Eureka! Meet the inventors'

    CERN Multimedia

    2006-01-01

    Fabio Sauli, the inventor of the GEM detector. Do you imagine an invention as a spontaneous brainchild emergi from the convoluted mind of some scatterbrained and dishevelled scientist? If so, you are mistaken! Join us at Microcosm for the next Discovery Monday at which inventors will be the guests of honour. There you will meet scientists who, thanks to their creativity, have made technological progress possible. By constantly rising to new scientific and technological challenges, CERN has delivered numerous innovations, particularly in the medical field. Members of the Crystal Clear collaboration and the inventor of the GEM detector will give talks about their innovations and their applications, in particular for medical purposes. You will also be able to speak to members of the Medipix collaboration, which is working on improvements to X-ray and gamma ray imaging techniques. The event will be conducted in French. Come to Microcosm, (Reception Building 33, Meyrin site), on Monday 6 February from 7.30 p...

  2. AN AHP MODEL FOR BRINGING EXPERTS TO CONSENSUS ON MEDICAL PAYMENT STANDARDS

    Institute of Scientific and Technical Information of China (English)

    Yuan-Huei HUANG; Pei-Yeh CHANG; Chih-Young HUNG; Kuei-Ing WANG; King-Jen CHANG

    2006-01-01

    Many countries with health insurance systems conduct periodic payment standards reform. How to reach consensus in setting payment standards among different specialties with different agendas has become a critical issue. The purpose of this study is to construct an analytic hierarchy process (AHP)model to obtain judgments from experts about the importance of "factors related to establishing payment standards in the national health insurance program". Under this goal, the first tier contains four evaluation aspects, and the second tier contains sixteen evaluation criteria divided into four groups.The AHP model was then used to collect and combine the opinions of experts through an empirical study. The results can be directly used to formulate standard values as the basis for establishing payment standards. The results of our study strongly support that an AHP model is effective in forming a consensus among surgical specialists.

  3. Microfluidics for medical applications

    OpenAIRE

    Berg, van den, T.J.T.P.; Segerink, Loes

    2015-01-01

    Lab-on-a-chip devices for point of care diagnostics have been present in clinics for several years now. Alongside their continual development, research is underway to bring the organs and tissue on-a-chip to the patient, amongst other medical applications of microfluidics. This book provides the reader with a comprehensive review of the latest developments in the application of microfluidics to medicine and is divided into three main sections. The first part of the book discusses the state-of...

  4. Does Satisfaction with Teaching Quality Factors Bring Conceptual Change?

    Directory of Open Access Journals (Sweden)

    Saifur Rehman Khan

    2014-05-01

    Full Text Available The purpose of this study is to explore classroom teaching quality factors that determine the satisfaction level and ultimately bring conceptual change among students. This study tests the theories of customer satisfaction in educational psychology research on a sample of 972 respondents. Overwhelmingly the results point out that male students were highly dissatisfied and have little impact on conceptual change whereas female students were reported significant level of satisfaction and conceptual change. In conclusion, detailed empirical analyses promote the theory of learning-satisfaction with classroom teaching bring conceptual change.

  5. An Approach to Implement Bring Your Own Device (BYOD Securely

    Directory of Open Access Journals (Sweden)

    Mr. Vishal Gupta

    2013-04-01

    Full Text Available BYOD (Bring Your Own Device is a business policy to allow employees to bring their own devices at their work. The same device is used in and out of the corporate office and during outside use, it may be connected to insecure internet and critical corporate data become public. This can be a big threat to the office as well as business strategies and future policies are derived from this data. In this paper an approach is explained to guard against this type of threat and to secure the corporate data even outside the corporate premises.

  6. Physics aids new medical techniques

    CERN Document Server

    CERN. Geneva

    2001-01-01

    Since the discovery of X-rays, fundamental physics has been a source of ideas for radiography and medical imaging. A new imaging method firmly rooted in particle physics was chosen by Time magazine as one of its "Inventions of the Year 2000". The award-winning invention in the medical science category was a scanner that combined the advantages of computer tomography with positron emission tomography. The use of these techniques, which depend on detecting and analysing electromagnetic radiation (X-rays or gamma rays respectively), show that detection techniques from particle physics have made, and continue to make, essential contributions to medical science. (0 refs).

  7. Medical Virology in Malaysia

    Institute of Scientific and Technical Information of China (English)

    Kaw Bing Chua

    2009-01-01

    Virology is a branch of biological science dealing with the study of viruses, and medical virology focuses on the study and control of diseases due to viruses that is of medical importance. The development of medical virology in Malaysia has its beginning in the Institute for Medical Research (IMR), following the establishment of the Division of Medical Zoology and Virus Research in the institute on 23 March 1953. The second institution in the country to establish diagnostic and research work in medical virology was Department of Medical Microbiology, Faculty of Medicine, University Malaya. This was followed by University Kebangsaan Malaysia, University Sains Malaysia and University of Sarawak Malaysia. The National Public Health Laboratory (NPHL) is the latest institution to establish a laboratory in 2003 for virus isolation and services to support country surveillance and outbreak investigation of infectious diseases due to viruses. In the field of medical virology, Malaysia contributed substantially in the areas of virus diagnostic services, development and research ranging from survey and documentation on the existence and prevalence of viruses causing diseases in Malaysia, clinical presentation and epidemiological features of virus diseases, evaluation of new diagnostic tests to pathogenesis of viral diseases. Malaysia contributed to the discoveries of at least 12 new viruses in the world. ASEAN plus Three (China, Japan, Republic of Korea) Emerging Infectious Programme was established to overcome the challenges and impact of emerging and re-emerging infectious diseases in this region. Malaysia as the co-ordinator of the laboratory component of the programme, contributed to strengthen the regional laboratory capability, capacity, laboratory-based surveillance and networking. The future of medical virology in Malaysia in terms of integration of diagnostic, reference and research to support the country's need will be enhanced and strengthened with the on

  8. Representation Discovery using Harmonic Analysis

    CERN Document Server

    Mahadevan, Sridhar

    2008-01-01

    Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu

  9. Denton Vacuum Discovery-550 Sputterer

    Data.gov (United States)

    Federal Laboratory Consortium — Description: CORAL Name: Sputter 2 Similar to the existing 4-Gun Denton Discovery 22 Sputter system, with the following enhancements: Specifications / Capabilities:...

  10. Optogenetics enlightens neuroscience drug discovery.

    Science.gov (United States)

    Song, Chenchen; Knöpfel, Thomas

    2016-02-01

    Optogenetics - the use of light and genetics to manipulate and monitor the activities of defined cell populations - has already had a transformative impact on basic neuroscience research. Now, the conceptual and methodological advances associated with optogenetic approaches are providing fresh momentum to neuroscience drug discovery, particularly in areas that are stalled on the concept of 'fixing the brain chemistry'. Optogenetics is beginning to translate and transit into drug discovery in several key domains, including target discovery, high-throughput screening and novel therapeutic approaches to disease states. Here, we discuss the exciting potential of optogenetic technologies to transform neuroscience drug discovery.

  11. Bringing internet connectivity to rural Zambia using a collaborative approach

    NARCIS (Netherlands)

    Matthee, K.W.; Mweemba, G.; Pais, A.V.; Starn, G.V.; Rijken, M.

    2007-01-01

    This paper presents an initiative to bring connectivity to rural Zambia using a collaborative approach. In particular, it focuses on a proof-of-concept Internet service that has been implemented in rural Macha located in the Southern Province of Zambia. The service operates using satellite terminals

  12. Foreign Aided: Why Democratization Brings Growth When Democracy Does Not

    DEFF Research Database (Denmark)

    Hariri, Jacob Gerner

    2015-01-01

    if being one does not? This article shows that a substantial and immediate influx of foreign aid into new democracies accounts for the positive growth effect of democratization. The domestic regime characteristics of neither democracy nor democratization therefore seems to bring growth. The...

  13. Bring Your Own Digital Device in Teacher Education

    Science.gov (United States)

    Newhouse, C. Paul; Cooper, Martin; Pagram, Jeremy

    2015-01-01

    This article reports on an investigation to advise a teacher education institution on the feasibility of having a "Bring Your Own Digital Device" policy for students. The investigation built on components of two research projects while adding the comprehensive testing of representative potential hardware and software platforms. The…

  14. On Bringing Industry English Teaching into College English Course

    Institute of Scientific and Technical Information of China (English)

    魏圆圆

    2016-01-01

    With the development of global economy, it’s becoming increasingly important to bring industry English into College English Course. But there are still many problems about industry English teaching in most colleges. This paper will analyze these problems and put forward effective measures to promote industry English teaching.

  15. Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

    Science.gov (United States)

    Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

    2007-01-01

    Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization promotes…

  16. Model Testing - Bringing the Ocean into the Laboratory

    DEFF Research Database (Denmark)

    Aage, Christian

    2000-01-01

    Hydrodynamic model testing, the principle of bringing the ocean into the laboratory to study the behaviour of the ocean itself and the response of man-made structures in the ocean in reduced scale, has been known for centuries. Due to an insufficient understanding of the physics involved, however...

  17. Bringing Curriculum Theory and Didactics Together: A Deweyan Perspective

    Science.gov (United States)

    Deng, Zongyi

    2016-01-01

    Using Dewey's method of resolution for resolving a dualism exemplified in "The Child and the Curriculum," this article reconciles and brings together two rival schools of thought--curriculum theory and didactics--in China. The central thesis is that the rapprochement requires a reconceptualisation of curriculum theory and didactics in…

  18. The Chemedian Brings Laughter to the Chemistry Classroom

    Science.gov (United States)

    Weitkamp, Emma; Burnet, Frank

    2007-01-01

    "The Chemedian and the Crazy Football Match" is a comic strip developed by the authors to bring humor to aspects of the UK primary science curriculum. The comic strip was tested in six English primary school classes (years 3-5; ages 7-10); over 150 children participated in the project, together with six teachers. Children found the comic strip fun…

  19. Excelsior: Bringing the Benefits of Modularisation to Excel

    CERN Document Server

    Paine, Jocelyn

    2008-01-01

    Excel lacks features for modular design. Had it such features, as do most programming languages, they would save time, avoid unneeded programming, make mistakes less likely, make code-control easier, help organisations adopt a uniform house style, and open business opportunities in buying and selling spreadsheet modules. I present Excelsior, a system for bringing these benefits to Excel.

  20. Interpretation of a discovery

    Directory of Open Access Journals (Sweden)

    Vučković Vladan

    2006-01-01

    Full Text Available The paper presents the development of the theory of asynchronous motors since Tesla’s discovery until the present day. The theory of steady state, as we know it today, was completed already during the first dozen of years. That was followed by a period of stagnation during a number of decades, when the theory of asynchronous motors was developed only in the framework of the general theory of electric machines, which was stimulated by the problems of the development of synchronous generators and big electric networks. It is only in our time that this simple motor, which was used for a long time just to perform crude tasks, became again the inspiration for the researchers and engineers who enabled it, with the help of power electronics and semi-conductor technology, to be used in the finest drives.

  1. Open source drug discovery--a new paradigm of collaborative research in tuberculosis drug development.

    Science.gov (United States)

    Bhardwaj, Anshu; Scaria, Vinod; Raghava, Gajendra Pal Singh; Lynn, Andrew Michael; Chandra, Nagasuma; Banerjee, Sulagna; Raghunandanan, Muthukurussi V; Pandey, Vikas; Taneja, Bhupesh; Yadav, Jyoti; Dash, Debasis; Bhattacharya, Jaijit; Misra, Amit; Kumar, Anil; Ramachandran, Srinivasan; Thomas, Zakir; Brahmachari, Samir K

    2011-09-01

    It is being realized that the traditional closed-door and market driven approaches for drug discovery may not be the best suited model for the diseases of the developing world such as tuberculosis and malaria, because most patients suffering from these diseases have poor paying capacity. To ensure that new drugs are created for patients suffering from these diseases, it is necessary to formulate an alternate paradigm of drug discovery process. The current model constrained by limitations for collaboration and for sharing of resources with confidentiality hampers the opportunities for bringing expertise from diverse fields. These limitations hinder the possibilities of lowering the cost of drug discovery. The Open Source Drug Discovery project initiated by Council of Scientific and Industrial Research, India has adopted an open source model to power wide participation across geographical borders. Open Source Drug Discovery emphasizes integrative science through collaboration, open-sharing, taking up multi-faceted approaches and accruing benefits from advances on different fronts of new drug discovery. Because the open source model is based on community participation, it has the potential to self-sustain continuous development by generating a storehouse of alternatives towards continued pursuit for new drug discovery. Since the inventions are community generated, the new chemical entities developed by Open Source Drug Discovery will be taken up for clinical trial in a non-exclusive manner by participation of multiple companies with majority funding from Open Source Drug Discovery. This will ensure availability of drugs through a lower cost community driven drug discovery process for diseases afflicting people with poor paying capacity. Hopefully what LINUX the World Wide Web have done for the information technology, Open Source Drug Discovery will do for drug discovery.

  2. SocialScope: Enabling Information Discovery on Social Content Sites

    CERN Document Server

    Amer-Yahia, Sihem; Yu, Cong

    2009-01-01

    Recently, many content sites have started encouraging their users to engage in social activities such as adding buddies on Yahoo! Travel and sharing articles with their friends on New York Times. This has led to the emergence of {\\em social content sites}, which is being facilitated by initiatives like OpenID (http://www.openid.net/) and OpenSocial (http://www.opensocial.org/). These community standards enable the open access to users' social profiles and connections by individual content sites and are bringing content-oriented sites and social networking sites ever closer. The integration of content and social information raises new challenges for {\\em information management and discovery} over such sites. We propose a logical architecture, named \\kw{SocialScope}, consisting of three layers, for tackling the challenges. The {\\em content management} layer is responsible for integrating, maintaining and physically accessing the content and social data. The {\\em information discovery} layer takes care of analyz...

  3. New Completeness Methods for Estimating Exoplanet Discoveries by Direct Detection

    CERN Document Server

    Brown, Robert A

    2010-01-01

    We report new methods for evaluating realistic observing programs that search stars for planets by direct imaging, where observations are selected from an optimized star list, and where stars can be observed multiple times. We show how these methods bring critical insight into the design of the mission & its instruments. These methods provide an estimate of the outcome of the observing program: the probability distribution of discoveries (detection and/or characterization), & an estimate of the occurrence rate of planets (eta). We show that these parameters can be accurately estimated from a single mission simulation, without the need for a complete Monte Carlo mission simulation, & we prove the accuracy of this new approach. Our methods provide the tools to define a mission for a particular science goal, for example defined by the expected number of discoveries and its confidence level. We detail how an optimized star list can be built & how successive observations can be selected. Our approa...

  4. [Knowledge discovery in database and its application in clinical diagnosis].

    Science.gov (United States)

    Lui, Hui; Qiu, Tianshuang

    2004-08-01

    Nowadays the tremendous amount of data has far exceeded our human ability for comprehension, and this has been particularly true for the medical database. However, traditional statistical techniques are no longer adequate for analyzing this vast collection of data. Knowledge discovery in database and data mining play an important role in analyzing data and uncovering important data patterns. This paper briefly presents the concepts of knowledge discovery in database and data mining, then describes the rough set theory, and gives some examples based on rough set.

  5. Genetic regulation and manipulation for natural product discovery.

    Science.gov (United States)

    Chen, Jianwei; Wu, Qihao; Hawas, Usama W; Wang, Hong

    2016-04-01

    Natural products are an important source of modern medical development, e.g., antibiotics, anticancers, immune modulators, etc. and will continue to be a powerful driving force for the discovery of novel potential drugs. In the heterologous hosts, natural products are biosynthesized using dedicated metabolic networks. By gene engineering, pathway reconstructing, and enzyme engineering, metabolic networks can be modified to synthesize novel compounds containing enhanced structural feature or produce a large quantity of known valuable bioactive compounds. The review introduces some important technical platforms and relevant examples of genetic regulation and manipulation to improve natural product titers or drive novel secondary metabolite discoveries.

  6. Discovery Learning Strategies in English

    Science.gov (United States)

    Singaravelu, G.

    2012-01-01

    The study substantiates that the effectiveness of Discovery Learning method in learning English Grammar for the learners at standard V. Discovery Learning is particularly beneficial for any student learning a second language. It promotes peer interaction and development of the language and the learning of concepts with content. Reichert and…

  7. Discoveries of isotopes by fission

    Indian Academy of Sciences (India)

    M Thoennessen

    2015-09-01

    Of the about 3000 isotopes presently known, about 20% have been discovered in fission. The history of fission as it relates to the discovery of isotopes as well as the various reaction mechanisms leading to isotope discoveries involving fission are presented.

  8. Service discovery using Bloom filters

    NARCIS (Netherlands)

    Goering, Patrick; Heijenk, Geert; Lelieveldt, B.P.F.; Haverkort, B.R.H.M.; Laat, de C.T.A.M.; Heijnsdijk, J.W.J.

    2006-01-01

    A protocol to perform service discovery in adhoc networks is introduced in this paper. Attenuated Bloom filters are used to distribute services to nodes in the neighborhood and thus enable local service discovery. The protocol has been implemented in a discrete event simulator to investigate the beh

  9. 29 CFR 2700.56 - Discovery; general.

    Science.gov (United States)

    2010-07-01

    ...(c) or 111 of the Act has been filed. 30 U.S.C. 815(c) and 821. (e) Completion of discovery... 29 Labor 9 2010-07-01 2010-07-01 false Discovery; general. 2700.56 Section 2700.56 Labor... Hearings § 2700.56 Discovery; general. (a) Discovery methods. Parties may obtain discovery by one or...

  10. A Proposal for Measuring Interactivity that Brings Learning Effectiveness

    Directory of Open Access Journals (Sweden)

    Tosh Yamamoto

    2010-03-01

    Full Text Available It is proposed in this paper that some type of way to measure and visualize interactivity in the multimedia or e-Learning contents is necessary in order to clearly identify interactivity that brings learning effectiveness. Interactivity during learning will arouse students’ intellectual curiosity and motivate them to learn further. Although the interaction in the communication between the teacher and his/her students in a regular classroom is ideal, it is not possible to maintain the equivalence in the multimedia or e-Learning contents. In order to rigorously formalize the field of measuring interactivity as a theory, theoretical constructs such as interactivity, interest, knowledge, and experience are redefined first. Then, the defined “interactivity” is broken down to subcomponents to develop an assessment tool for the interactivity which brings learning effectiveness. In the end, it is proved that the interactivity in learning can be measured.

  11. Academic medical product development: an emerging alliance of technology transfer organizations and the CTSA.

    Science.gov (United States)

    Rose, Lynn M; Everts, Maaike; Heller, Caren; Burke, Christine; Hafer, Nathaniel; Steele, Scott

    2014-12-01

    To bring the benefits of science more quickly to patient care, the NIH National Center Advancing Translational Sciences (NCATS) supports programs that enhance the development, testing, and implementation of new medical products and procedures. The NCATS clinical and translational science award (CTSA) program is central to that mission; creating an academic home for clinical and translational science and supporting those involved in the discovery and development of new health-related inventions. The technology transfer Offices (TTO) of CTSA-funded universities can be important partners in the development process; facilitating the transfer of medical research to the commercial sector for further development and ultimately, distribution to patients. The Aggregating Intellectual Property (IP) Working Group (AWG) of the CTSA public private partnerships key function committee (PPP-KFC) developed a survey to explore how CTSA-funded institutions currently interface with their respective TTOs to support medical product development. The results suggest a range of relationships across institutions; approximately half have formal collaborative programs, but only a few have well-connected programs. Models of collaborations are described and provided as examples of successful CTSA/TTO partnerships that have increased the value of health-related inventions as measured by follow-on funding and industry involvement; either as a consulting partner or licensee.

  12. Bringing together Anthropology, Ethnology and Folklore: From Factions to Union

    OpenAIRE

    Fournier, Laurent Sébastien

    2016-01-01

    In this paper I first focus on the foundation of the AFEA (Association Française d’Ethnologie et d’Anthropologie) and I try to find out how this new association has been managing (or not) to bring together anthropology and folklore since its foundation in 2009. Using this French example, I also try to shed light on more global discussions going on between folklorists, ethnologists and anthropologists worldwide. I present different models of possible cooperation between anthropologists and fol...

  13. Foreign Aided: Why Democratization Brings Growth When Democracy Does Not

    OpenAIRE

    Hariri, Jacob Gerner

    2015-01-01

    There is an unresolved puzzle in research on the economics of democracy: While there is consensus that democracy is not generally associated with higher rates of economic growth, a recent literature has found that democratization is followed by growth. Why should becoming a democracy bring growth if being one does not? This article shows that the positive growth effect of democratization is accounted for by a substantial and immediate influx of foreign aid into new democracies. The domestic r...

  14. Discovery and Formulation

    Science.gov (United States)

    Clark, Don; Rodger, Caroline

    The uses of Raman spectroscopy in active pharmaceutical ingredient (API) discovery, development and release cover a wide variety of sample types and applications. However, the technique does not have a high prominence in the pharmaceutical industry despite being recognised by regulatory authorities as a suitable methodology for the analysis and release of pharmaceutical API and products. One reason is that other analytical techniques are well established and changing to Raman methods is cost prohibitive considering return on investments (ROI). In addition the technique is often regarded as being one for "experts" and not one for main stream applications. As a consequence Raman spectroscopy is frequently the 2nd or 3rd technique of choice for a specific application. However, due to its unique sampling attributes (e.g. micro and macro measurements direct from the sample, through glass, from well plates or in the presence of water) and selectivity, applications of this technology are found throughout the life cycles of pharmaceutical products. It can therefore be considered to be a spectroscopic common denominator. This chapter highlights a number of routine, specialised and niche Raman spectroscopy applications which have been used in the development of new medicines while detailing some of the limitations of these approaches.

  15. Discovery Mondays: Surveyors' Tools

    CERN Multimedia

    2003-01-01

    Surveyors of all ages, have your rulers and compasses at the ready! This sixth edition of Discovery Monday is your chance to learn about the surveyor's tools - the state of the art in measuring instruments - and see for yourself how they work. With their usual daunting precision, the members of CERN's Surveying Group have prepared some demonstrations and exercises for you to try. Find out the techniques for ensuring accelerator alignment and learn about high-tech metrology systems such as deviation indicators, tracking lasers and total stations. The surveyors will show you how they precisely measure magnet positioning, with accuracy of a few thousandths of a millimetre. You can try your hand at precision measurement using different types of sensor and a modern-day version of the Romans' bubble level, accurate to within a thousandth of a millimetre. You will learn that photogrammetry techniques can transform even a simple digital camera into a remarkable measuring instrument. Finally, you will have a chance t...

  16. Discovery of neptunium

    International Nuclear Information System (INIS)

    This paper reports that a number of distinguished scientist, all knowledgeable about the periodic table, irradiated uranium with neutrons during 1934-1938. They observed a number of beta-emitting activities that seemed to be from transuranium elements. discovery of fission and of neptunium was delayed because they assumed that elements 93 and 94 would have chemical properties similar to those of rhenium and osmium, respectively. After fission was finally demonstrated, as new search for element 93 was initiated by McMillan, who showed that when thin films of uranium are exposed to neutrons, high-energy fission products leave the film; 23-min and 2.3-day activities remain. The 23-min activity was known to be an isotope of uranium. In May 1940 Abelson produced conclusive evidence that the 2.3 day activity was from the transuranium element 93. In a reduce state, element 93 coprecipitates with rare earth fluorides. In an oxidized state, the fluoride no longer coprecipitates. Behavior of element 93 was found to resemble that of uranium

  17. Bringing History Home. Postcolonial Immigrants and the Dutch Cultural Arena

    Directory of Open Access Journals (Sweden)

    S. Legêne

    2011-01-01

    Full Text Available Bringing History Home: Postcolonial Immigrants and the Dutch Cultural ArenaThree Dutch-language monographs published in 2008-2009 by Ulbe Bosma, Lizzy van Leeuwen and Gert Oostindie in the context of the interdisciplinary research programme Bringing History Home, present a history of identity politics in relation to ‘postcolonial immigrants’. This term refers to some 500,000 people who since 1945 arrived in the Netherlands from Indonesia and the former Dutch New Guinea, Suriname or the Antillean islands in the Caribbean. Bosma traces the development of postcolonial immigrant organizations. In interaction with government policies, these organizations moved from mere socioeconomic emancipation struggles to mere cultural identity politics. Van Leeuwen takes such cultural identity politics as the starting point for her analysis of Indo-Dutch and Dutch Indies cultural initiatives and the competing interests at stake in the Indies heritage discourse. Oostindie discusses these developments in terms of community development and change within Dutch society at large. He introduces the notion of a ‘postcolonial bonus’. In postcolonial Netherlands, this bonus was available to immigrants on the grounds of a shared colonial past. Today, this bonus is (almost spent. The review discusses the three monographs, as well as the coherence of Bringing History Home as a research programme. Legêne argues, that notwithstanding valuable research outcomes, the very category of postcolonial immigrants does not constitute a convincing category of analysis.

  18. [A medical consumable material management information system].

    Science.gov (United States)

    Tang, Guoping; Hu, Liang

    2014-05-01

    Medical consumables material is essential supplies to carry out medical work, which has a wide range of varieties and a large amount of usage. How to manage it feasibly and efficiently that has been a topic of concern to everyone. This article discussed about how to design a medical consumable material management information system that has a set of standardized processes, bring together medical supplies administrator, suppliers and clinical departments. Advanced management mode, enterprise resource planning (ERP) applied to the whole system design process. PMID:25241525

  19. The role of industry in bringing foods for particular nutritional uses (PARNUTS) to the market.

    Science.gov (United States)

    Leathwood, P; MacLean, W; Uauy, R

    1999-12-01

    The process of bringing new food products from innovation to implementation requires a high level of interaction between researchers, marketers, and consumers. Researchers from industry and academia have the task of developing products that are not only efficacious, but also have a high probability of consumer acceptance. For most foods, industry must provide the most leadership in finding new product concepts, determining which products will have the widest markets, and in funding research and development. To accomplish these tasks, industry has forged partnerships with academic centers and scientists who excel in research and development, and continues to search for the best ways to communicate with consumers. For some FSMPs, other considerations, such as medical and nutritional needs (e.g., products for inborn errors of metabolism), might change the pattern of industry leadership. The following article explores the ways in which industry can facilitate the development and acceptance of beneficial and marketable food products. PMID:10723641

  20. Medical Management

    Science.gov (United States)

    ... email share facebook twitter google plus linkedin Medical Management Although there’s no cure for CMT, there are ... individualized physical therapy program. For more on medical management of CMT, see Surgery Sometimes, Bracing Often, Caution ...

  1. Medical Illustration

    Science.gov (United States)

    ... and authentic illustrations used in the publication of medical books, journals, films, videotapes, exhibits, posters, wall charts, and computer programs. A medical illustrator may also work as a member of ...

  2. Medical Identity

    DEFF Research Database (Denmark)

    Musaeus, Peter

    2015-01-01

    Purpose: To examine philosophical stances underpinning medical identity and assess the conceptual relationship between physician, medical practice and culture. Argument: Medical identity is about the ideals and moral positions that physicians take when justifying themselves. Medical identity...... hedonistic versus sentimentalist approaches to medical identity. The sociocultural philosophical analysis of medical identity can shed light on what it means conceptually for a physician to harbor beliefs associated with him/her being taken to be an autonomous professional. It is important because it touches...... on the meaning of being a compassionate, good and skilled physician, making its relevance to person-centered medicine self-evident. Conclusion: Medical identity should be analyzed with reference to literature, philosophy and medical practice in order for the physician to exercise a reflective position...

  3. Coal Discovery Trail officially opens

    Energy Technology Data Exchange (ETDEWEB)

    Gallinger, C. [Elk Valley Coal Corporation, Sparwood, BC (Canada)

    2004-09-01

    The opening of the 30-kilometre Coal Discovery Trail in August is described. The trail, through a pine, spruce, and larch forest, extends from Sparwood to Fernie and passes through Hosmer, a historic mining site. The trail, part of the Elk Valley Coal Discovery Centre, will be used for hiking, bicycling, horseback riding, and cross-country skiing. The Coal Discovery Centre will provide an interpretive centre that concentrates on history of coal mining and miners, preservation of mining artifacts and sites, and existing technology. 3 figs.

  4. Deep Learning in Drug Discovery.

    Science.gov (United States)

    Gawehn, Erik; Hiss, Jan A; Schneider, Gisbert

    2016-01-01

    Artificial neural networks had their first heyday in molecular informatics and drug discovery approximately two decades ago. Currently, we are witnessing renewed interest in adapting advanced neural network architectures for pharmaceutical research by borrowing from the field of "deep learning". Compared with some of the other life sciences, their application in drug discovery is still limited. Here, we provide an overview of this emerging field of molecular informatics, present the basic concepts of prominent deep learning methods and offer motivation to explore these techniques for their usefulness in computer-assisted drug discovery and design. We specifically emphasize deep neural networks, restricted Boltzmann machine networks and convolutional networks.

  5. Deep Learning in Drug Discovery.

    Science.gov (United States)

    Gawehn, Erik; Hiss, Jan A; Schneider, Gisbert

    2016-01-01

    Artificial neural networks had their first heyday in molecular informatics and drug discovery approximately two decades ago. Currently, we are witnessing renewed interest in adapting advanced neural network architectures for pharmaceutical research by borrowing from the field of "deep learning". Compared with some of the other life sciences, their application in drug discovery is still limited. Here, we provide an overview of this emerging field of molecular informatics, present the basic concepts of prominent deep learning methods and offer motivation to explore these techniques for their usefulness in computer-assisted drug discovery and design. We specifically emphasize deep neural networks, restricted Boltzmann machine networks and convolutional networks. PMID:27491648

  6. Cyberinfrastructure for Atmospheric Discovery

    Science.gov (United States)

    Wilhelmson, R.; Moore, C. W.

    2004-12-01

    Each year across the United States, floods, tornadoes, hail, strong winds, lightning, hurricanes, and winter storms cause hundreds of deaths, routinely disrupt transportation and commerce, and result in billions of dollars in annual economic losses . MEAD and LEAD are two recent efforts aimed at developing the cyberinfrastructure for studying and forecasting these events through collection, integration, and analysis of observational data coupled with numerical simulation, data mining, and visualization. MEAD (Modeling Environment for Atmospheric Discovery) has been funded for two years as an NCSA (National Center for Supercomputing Applications) Alliance Expedition. The goal of this expedition has been the development/adaptation of cyberinfrastructure that will enable research simulations, datamining, machine learning and visualization of hurricanes and storms utilizing the high performance computing environments including the TeraGrid. Portal grid and web infrastructure are being tested that will enable launching of hundreds of individual WRF (Weather Research and Forecasting) simulations. In a similar way, multiple Regional Ocean Modeling System (ROMS) or WRF/ROMS simulations can be carried out. Metadata and the resulting large volumes of data will then be made available for further study and for educational purposes using analysis, mining, and visualization services. Initial coupling of the ROMS and WRF codes has been completed and parallel I/O is being implemented for these models. Management of these activities (services) are being enabled through Grid workflow technologies (e.g. OGCE). LEAD (Linked Environments for Atmospheric Discovery) is a recently funded 5-year, large NSF ITR grant that involves 9 institutions who are developing a comprehensive national cyberinfrastructure in mesoscale meteorology, particularly one that can interoperate with others being developed. LEAD is addressing the fundamental information technology (IT) research challenges needed

  7. Cannabinoids: Medical implications.

    Science.gov (United States)

    Schrot, Richard J; Hubbard, John R

    2016-05-01

    Herbal cannabis has been used for thousands of years for medical purposes. With elucidation of the chemical structures of tetrahydrocannabinol (THC) and cannabidiol (CBD) and with discovery of the human endocannabinoid system, the medical usefulness of cannabinoids has been more intensively explored. While more randomized clinical trials are needed for some medical conditions, other medical disorders, like chronic cancer and neuropathic pain and certain symptoms of multiple sclerosis, have substantial evidence supporting cannabinoid efficacy. While herbal cannabis has not met rigorous FDA standards for medical approval, specific well-characterized cannabinoids have met those standards. Where medical cannabis is legal, patients typically see a physician who "certifies" that a benefit may result. Physicians must consider important patient selection criteria such as failure of standard medical treatment for a debilitating medical disorder. Medical cannabis patients must be informed about potential adverse effects, such as acute impairment of memory, coordination and judgment, and possible chronic effects, such as cannabis use disorder, cognitive impairment, and chronic bronchitis. In addition, social dysfunction may result at work/school, and there is increased possibility of motor vehicle accidents. Novel ways to manipulate the endocannbinoid system are being explored to maximize benefits of cannabinoid therapy and lessen possible harmful effects. Key messages The medical disorders with the current best evidence that supports a benefit for cannabinoid use are the following: multiple sclerosis patient-reported symptoms of spasticity (nabiximols, nabilone, dronabinol, and oral cannabis extract), multiple sclerosis central pain or painful spasms (nabiximols, nabilone, dronabinol, and oral cannabis extract), multiple sclerosis bladder frequency (nabiximols), and chronic cancer pain/neuropathic pain (nabiximols and smoked THC). Herbal cannabis has not met rigorous US FDA

  8. Serendipity: Accidental Discoveries in Science

    Science.gov (United States)

    Roberts, Royston M.

    1989-06-01

    Many of the things discovered by accident are important in our everyday lives: Teflon, Velcro, nylon, x-rays, penicillin, safety glass, sugar substitutes, and polyethylene and other plastics. And we owe a debt to accident for some of our deepest scientific knowledge, including Newton's theory of gravitation, the Big Bang theory of Creation, and the discovery of DNA. Even the Rosetta Stone, the Dead Sea Scrolls, and the ruins of Pompeii came to light through chance. This book tells the fascinating stories of these and other discoveries and reveals how the inquisitive human mind turns accident into discovery. Written for the layman, yet scientifically accurate, this illuminating collection of anecdotes portrays invention and discovery as quintessentially human acts, due in part to curiosity, perserverance, and luck.

  9. Discovery of the Arsenic Isotopes

    CERN Document Server

    Shore, A; Heim, M; Schuh, A; Thoennessen, M

    2009-01-01

    Twenty-nine arsenic isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  10. Discovery of the Scandium Isotopes

    CERN Document Server

    Meierfrankenfeld, D

    2010-01-01

    Twenty-three scandium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  11. Discovery of the Tungsten Isotopes

    OpenAIRE

    A. Fritsch; Ginepro, J. Q.; Heim, M.; Schuh, A.; SHORE, A.; Thoennessen, M

    2009-01-01

    Thirty-five tungsten isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  12. Discovery of the Vanadium Isotopes

    OpenAIRE

    SHORE, A.; A. Fritsch; Heim, M.; Schuh, A.; Thoennessen, M

    2009-01-01

    Twenty-four vanadium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  13. Discovery of the Barium Isotopes

    OpenAIRE

    SHORE, A.; A. Fritsch; Ginepro, J. Q.; Heim, M.; Schuh, A.; Thoennessen, M

    2009-01-01

    Thirty-eight barium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  14. Discovery of the Silver Isotopes

    OpenAIRE

    Schuh, A.; A. Fritsch; Ginepro, J. Q.; Heim, M.; SHORE, A.; Thoennessen, M

    2009-01-01

    Thirty-eight silver isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  15. Discovery of the Cadmium Isotopes

    OpenAIRE

    Amos, S.; Thoennessen, M

    2009-01-01

    Thirty-seven cadmium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  16. Discovery of the Krypton Isotopes

    OpenAIRE

    Heim, M.; A. Fritsch; Schuh, A.; SHORE, A.; Thoennessen, M

    2009-01-01

    Thirty-two krypton isotopes have been observed so far; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  17. Discovery of the Iron Isotopes

    OpenAIRE

    Schuh, A.; A. Fritsch; Heim, M.; SHORE, A.; Thoennessen, M

    2009-01-01

    Twenty-eight iron isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  18. Discovery of the Gold Isotopes

    OpenAIRE

    Schuh, A.; A. Fritsch; Ginepro, J. Q.; Heim, M.; SHORE, A.; Thoennessen, M

    2009-01-01

    Thirty-six gold isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  19. Discovery of the Cobalt Isotopes

    OpenAIRE

    Szymanski, T; Thoennessen, M

    2009-01-01

    Twenty-six cobalt isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  20. Taxonomy Enabled Discovery (TED) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposal addresses the NASA's need to enable scientific discovery and the topic's requirements for: processing large volumes of data, commonly available on the...

  1. Medication safety.

    Science.gov (United States)

    Keohane, Carol A; Bates, David W

    2008-03-01

    Patient safety is a state of mind, not a technology. The technologies used in the medical setting represent tools that must be properly designed, used well, and assessed on an on-going basis. Moreover, in all settings, building a culture of safety is pivotal for improving safety, and many nontechnologic approaches, such as medication reconciliation and teaching patients about their medications, are also essential. This article addresses the topic of medication safety and examines specific strategies being used to decrease the incidence of medication errors across various clinical settings.

  2. Drug design and discovery: translational biomedical science varies among countries.

    Science.gov (United States)

    Weaver, Ian N; Weaver, Donald F

    2013-10-01

    Drug design and discovery is an innovation process that translates the outcomes of fundamental biomedical research into therapeutics that are ultimately made available to people with medical disorders in many countries throughout the world. To identify which nations succeed, exceed, or fail at the drug design/discovery endeavor--more specifically, which countries, within the context of their national size and wealth, are "pulling their weight" when it comes to developing medications targeting the myriad of diseases that afflict humankind--we compiled and analyzed a comprehensive survey of all new drugs (small molecular entities and biologics) approved annually throughout the world over the 20-year period from 1991 to 2010. Based upon this analysis, we have devised prediction algorithms to ascertain which countries are successful (or not) in contributing to the worldwide need for effective new therapeutics.

  3. Verbessern Discovery Systeme die Informationskompetenz?

    OpenAIRE

    Dörte Böhner

    2013-01-01

    Mit dem Auftauchen von Discovery Systemen entstand die Hoffnung, dass der Schulungsbedarf und damit der Aufwand für die Vermittlung von Informationskompetenz verringert und durch die Systeme selbst die Informationskompetenz verbessert werden kann. Dieser Beitrag beleuchtet kritisch das Zusam­menspiel von Discovery Systemen und Informationskompetenz anhand von Recherchegewohnheiten eher untrainierter Studierender. Anhand einer kurzen Gegenüberstellung der unterschiedlichen Recherche­konzepte v...

  4. Recent discoveries of influenza A drug target sites to combat virus replication.

    Science.gov (United States)

    Patel, Hershna; Kukol, Andreas

    2016-06-15

    Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies. PMID:27284062

  5. Discovery Mondays: crystals and particles for medicine

    CERN Multimedia

    2003-01-01

    Question: what are as heavy as lead, as clear as glass, and appear as tiny specks in a doctor's scanner but large as life in a physicist's detector? Answer: the crystals you will be able to observe in all their facets on 1 September at the start of a new season of Discovery Mondays at Microcosm. Come along and meet the CERN physicists who use crystals not only in their detectors but also in the latest generation of scanners. Four workshops will be organised, each devoted to a different medical imaging technique. The first workshop will be run by a physicist from the Crystal Clear collaboration, who will present her collaboration's special breed of crystals, which emit light when they are traversed by high-energy particles, and explain to you these crystals' role in Positron Emission Tomographs. The second workshop will focus on an imaging technique known as the Compton Camera, also based on scintillating crystals. Crystals worth looking at and admiring. Come to the next Discovery Monday to find out how they ...

  6. Database systems for knowledge-based discovery.

    Science.gov (United States)

    Jagarlapudi, Sarma A R P; Kishan, K V Radha

    2009-01-01

    Several database systems have been developed to provide valuable information from the bench chemist to biologist, medical practitioner to pharmaceutical scientist in a structured format. The advent of information technology and computational power enhanced the ability to access large volumes of data in the form of a database where one could do compilation, searching, archiving, analysis, and finally knowledge derivation. Although, data are of variable types the tools used for database creation, searching and retrieval are similar. GVK BIO has been developing databases from publicly available scientific literature in specific areas like medicinal chemistry, clinical research, and mechanism-based toxicity so that the structured databases containing vast data could be used in several areas of research. These databases were classified as reference centric or compound centric depending on the way the database systems were designed. Integration of these databases with knowledge derivation tools would enhance the value of these systems toward better drug design and discovery.

  7. Database systems for knowledge-based discovery.

    Science.gov (United States)

    Jagarlapudi, Sarma A R P; Kishan, K V Radha

    2009-01-01

    Several database systems have been developed to provide valuable information from the bench chemist to biologist, medical practitioner to pharmaceutical scientist in a structured format. The advent of information technology and computational power enhanced the ability to access large volumes of data in the form of a database where one could do compilation, searching, archiving, analysis, and finally knowledge derivation. Although, data are of variable types the tools used for database creation, searching and retrieval are similar. GVK BIO has been developing databases from publicly available scientific literature in specific areas like medicinal chemistry, clinical research, and mechanism-based toxicity so that the structured databases containing vast data could be used in several areas of research. These databases were classified as reference centric or compound centric depending on the way the database systems were designed. Integration of these databases with knowledge derivation tools would enhance the value of these systems toward better drug design and discovery. PMID:19727614

  8. Beyond the Cell: Using Multiscalar Topics to Bring Interdisciplinarity into Undergraduate Cellular Biology Courses

    Science.gov (United States)

    Weber, Carolyn F.

    2016-01-01

    Western science has grown increasingly reductionistic and, in parallel, the undergraduate life sciences curriculum has become disciplinarily fragmented. While reductionistic approaches have led to landmark discoveries, many of the most exciting scientific advances in the late 20th century have occurred at disciplinary interfaces; work at these interfaces is necessary to manage the world’s looming problems, particularly those that are rooted in cellular-level processes but have ecosystem- and even global-scale ramifications (e.g., nonsustainable agriculture, emerging infectious diseases). Managing such problems requires comprehending whole scenarios and their emergent properties as sums of their multiple facets and complex interrelationships, which usually integrate several disciplines across multiple scales (e.g., time, organization, space). This essay discusses bringing interdisciplinarity into undergraduate cellular biology courses through the use of multiscalar topics. Discussing how cellular-level processes impact large-scale phenomena makes them relevant to everyday life and unites diverse disciplines (e.g., sociology, cell biology, physics) as facets of a single system or problem, emphasizing their connections to core concepts in biology. I provide specific examples of multiscalar topics and discuss preliminary evidence that using such topics may increase students’ understanding of the cell’s position within an ecosystem and how cellular biology interfaces with other disciplines. PMID:27146162

  9. Beyond the Cell: Using Multiscalar Topics to Bring Interdisciplinarity into Undergraduate Cellular Biology Courses.

    Science.gov (United States)

    Weber, Carolyn F

    2016-01-01

    Western science has grown increasingly reductionistic and, in parallel, the undergraduate life sciences curriculum has become disciplinarily fragmented. While reductionistic approaches have led to landmark discoveries, many of the most exciting scientific advances in the late 20th century have occurred at disciplinary interfaces; work at these interfaces is necessary to manage the world's looming problems, particularly those that are rooted in cellular-level processes but have ecosystem- and even global-scale ramifications (e.g., nonsustainable agriculture, emerging infectious diseases). Managing such problems requires comprehending whole scenarios and their emergent properties as sums of their multiple facets and complex interrelationships, which usually integrate several disciplines across multiple scales (e.g., time, organization, space). This essay discusses bringing interdisciplinarity into undergraduate cellular biology courses through the use of multiscalar topics. Discussing how cellular-level processes impact large-scale phenomena makes them relevant to everyday life and unites diverse disciplines (e.g., sociology, cell biology, physics) as facets of a single system or problem, emphasizing their connections to core concepts in biology. I provide specific examples of multiscalar topics and discuss preliminary evidence that using such topics may increase students' understanding of the cell's position within an ecosystem and how cellular biology interfaces with other disciplines. PMID:27146162

  10. Verbessern Discovery Systeme die Informationskompetenz?

    Directory of Open Access Journals (Sweden)

    Dörte Böhner

    2013-09-01

    Full Text Available Mit dem Auftauchen von Discovery Systemen entstand die Hoffnung, dass der Schulungsbedarf und damit der Aufwand für die Vermittlung von Informationskompetenz verringert und durch die Systeme selbst die Informationskompetenz verbessert werden kann. Dieser Beitrag beleuchtet kritisch das Zusam­menspiel von Discovery Systemen und Informationskompetenz anhand von Recherchegewohnheiten eher untrainierter Studierender. Anhand einer kurzen Gegenüberstellung der unterschiedlichen Recherche­konzepte von Suchmaschinen und bibliothekarischen Rechercheangeboten werden Rückschlüsse auf die zu fördernden Schwerpunkte bei der Informationskompetenz gezogen und untersucht, welche Schlüsselrolle Discovery Systeme dabei spielen.The dissemination of discovery systems has raised hopes that the need for extensive teaching of information literacy might be reduced in the future. Also, their intuitive approach has been hopefully seen to enable the development of a better information literacy. This article critically focusses on the interaction of discovery systems and information literacy by analysing research behaviours of comparatively untrained students. In order to define which specific themes should be promoted by information literacy education, the author examines various research concepts of search engines as well as research offers of libraries. On this basis the key role of discovery systems will be explored.

  11. Datamining on distributed medical databases

    DEFF Research Database (Denmark)

    Have, Anna Szynkowiak

    2004-01-01

    This Ph.D. thesis focuses on clustering techniques for Knowledge Discovery in Databases. Various data mining tasks relevant for medical applications are described and discussed. A general framework which combines data projection and data mining and interpretation is presented. An overview...... is available. If data is unlabeled, then it is possible to generate keywords (in case of textual data) or key-patterns, as an informative representation of the obtained clusters. The methods are applied on simple artificial data sets, as well as collections of textual and medical data. In Danish: Denne ph...

  12. Get Involved in Planetary Discoveries through New Worlds, New Discoveries

    Science.gov (United States)

    Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA

    2013-01-01

    "New Worlds, New Discoveries" is a synthesis of NASA’s 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun’s family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site’s event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to

  13. Medical makeup: the correction of hyperpigmentation disorders.

    Science.gov (United States)

    Nonni, J

    2012-12-01

    Medical makeup corrects skin tone imperfections with dermocosmetic products, which bring together tolerance efficacy, colour neutralization and sun protection. Highly suitable for imperfections caused by hyperpigmentation, it allows patients affected by these disorders to cover them up effectively and discretely, giving them a better quality of life.

  14. [Medical makeup: the correction of hyperpigmentation disorders].

    Science.gov (United States)

    Nonni, J

    2012-11-01

    Medical makeup corrects skin tone imperfections with dermo-cosmetic products, which bring together tolerance efficacy, colour neutralization and sun protection. Highly suitable for imperfections caused by hyperpigmentation, it allows patients affected by these disorders to cover them up effectively and discretely, giving them a better quality of life.

  15. Infuriating Tensions: Science and the Medical Student.

    Science.gov (United States)

    Bishop, J. Michael

    1984-01-01

    Contemporary medical students, it is suggested, view science in particular and the intellect in general as difficult allies at best. What emerges are physicians without inquiring minds, physicians who bring to the bedside not curiosity and a desire to understand but a set of reflexes. (MLW)

  16. BRINGING CIVILIZATION: SAVAGERY AND THE TAMING OF THE SAVAGE

    Directory of Open Access Journals (Sweden)

    Nicholas D. Newman

    2015-01-01

    Full Text Available “See, the Conqu’ring Hero Comes” goes the famous chorus from Handel’s Judas Maccabeus, but how does the hero conquer? Achilles defeats his enemies through his extraordinary prowess in battle, Odysseus by using his wit, but some heroes must abandon the trappings of civilization in order to conquer. This paper examines two examples of such heroes from Germanic and Greco-Roman myth: Beowulf and Herakles. In the texts analyzed, these heroes not only set aside their civilized veneer, but must journey into the territory of the monster they wish to destroy and there use savagery to defeat the savage, in order to bring civilization.

  17. Bringing fiber to the home to rural areas in Denmark

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Riaz, M. Tahir

    2009-01-01

    ) is developing in Denmark, and that FTTH is also being deployed in rural areas. A main reason for this is that consumer-owed utility companies have decided to invest heavily in the field, to a large extent with the philosophy that, since all consumers are a part of the investment, everybody should also benefit...... from it. As a result of these investments, FTTH availability and penetration has increased significantly over the last years. In the end of the paper, we highlight the importance of studying the actual impact of bringing FTTH to these areas....

  18. Bringing indigenous ownership back to the private sector

    DEFF Research Database (Denmark)

    Kragelund, Peter

    Driven by across-the-board liberalizations and the commodity price boom, Zambia has recently experienced an upsurge in foreign ownership over key parts of its economy. Albeit investors from all over the world have sought to make the most of the current situation in Zambia, Chinese investors have...... been particularly present in all sectors of the Zambian economy. Foreign ownership, however, is not new to African societies and several African countries pursued indigenisation policies in the wake of independence to bring ownership back to their own citizens. Now indigenisation policies thrive again...

  19. Bring Your Own Device in the Information Literacy Classroom

    OpenAIRE

    Stonebraker, Ilana; Robertshaw, M Brooke; Kirkwood, Hal; Dugan, Mary

    2014-01-01

    In the 2013 school year, a team of librarians in the Parrish Library of Management and Economics at Purdue University taught a business information literacy course to approximately 500 management students in eight 70-person sessions. Due to limitations on a set of iPads borrowed from another department, one of two concurrent classes was taught with a set of iPads, while another had a Bring Your Own Device (BYOD) policy, where students brought their own laptops or iPads. Focus groups, observat...

  20. The Key to Stabilizing House Prices: Bring Them Down

    OpenAIRE

    Dean Baker

    2008-01-01

    This report states that bringing about the rapid adjustment of house prices to trend levels is the best means of returning stability to the housing market. The paper also calls for the restriction of GSE capital in bubble-inflated markets, with the intent of forcing house prices in these areas to return to trend level. The removal of capital from bubble markets and the consequent infusion of loans into non-bubble markets would stabilize prices in these areas, thus preventing a downward price ...

  1. Bringing a Finnish Company to the Russian E-Market

    OpenAIRE

    Veselova, Victoria

    2012-01-01

    The main objective of the project was to enable a small business case company that is operating in the town of Lappeenranta, Finland, to reach successfully its target segment (Russian consumers) with the help of digital technology in order to increase sales both in its physical shop and in online store. In order to reach the aim of the project and bring Russian consumers and the case company together by the means of electronic marketing, a marketing plan for the promotional campaigns of th...

  2. Marie Curie's contribution to Medical Physics.

    Science.gov (United States)

    Jean-Claude, Rosenwald; Nüsslin, Fridtjof

    2013-09-01

    On occasion of its 50th anniversary, the International Organization for Medical Physics (IOMP) from now on is going to celebrate annually an International Day of Medical Physics for which the 7th November, the birthday of Marie Sklodowska Curie, a most exceptional character in science at all and a pioneer of medical physics, has been chosen. This article briefly outlines her outstanding personality, sketches her fundamental discovery of radioactivity and emphasizes the impact of her various achievements on the development of medical physics at large.

  3. Medical waste: a minimal hazard.

    Science.gov (United States)

    Keene, J H

    1991-11-01

    Medical waste is a subset of municipal waste, and regulated medical waste comprises less than 1% of the total municipal waste volume in the United States. As part of the overall waste stream, medical waste does contribute in a relative way to the aesthetic damage of the environment. Likewise, some small portion of the total release of hazardous chemicals and radioactive materials is derived from medical wastes. These comments can be made about any generated waste, regulated or unregulated. Healthcare professionals, including infection control personnel, microbiologists, public health officials, and others, have unsuccessfully argued that there is no evidence that past methods of treatment and disposal of regulated medical waste constitute any public health hazard. Historically, discovery of environmental contamination by toxic chemical disposal has followed assurances that the material was being disposed of in a safe manner. Therefore, a cynical public and its elected officials have demanded proof that the treatment and disposal of medical waste (i.e., infectious waste) do not constitute a public health hazard. Existent studies on municipal waste provide that proof. In order to argue that the results of these municipal waste studies are demonstrative of the minimal potential infectious environmental impact and lack of public health hazard associated with medical waste, we must accept the following: that the pathogens are the same whether they come from the hospital or the community, and that the municipal waste studied contained waste materials we now define as regulated medical waste.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Universal Knowledge Discovery from Big Data: Towards a Paradigm Shift from 'Knowledge Discovery' to 'Wisdom Discovery'

    OpenAIRE

    Shen, Bin

    2014-01-01

    Many people hold a vision that big data will provide big insights and have a big impact in the future, and big-data-assisted scientific discovery is seen as an emerging and promising scientific paradigm. However, how to turn big data into deep insights with tremendous value still remains obscure. To meet the challenge, universal knowledge discovery from big data (UKD) is proposed. The new concept focuses on discovering universal knowledge, which exists in the statistical analyses of big data ...

  5. A Review of Bring Your Own Device on Security Issues

    Directory of Open Access Journals (Sweden)

    Morufu Olalere

    2015-04-01

    Full Text Available Mobile computing has supplanted internet computing because of the proliferation of cloud-based applications and mobile devices (such as smartphones, palmtops, and tablets. As a result of this, workers bring their mobile devices to the workplace and use them for enterprise work. The policy of allowing the employees to work with their own personal mobile devices is called Bring Your Own Devices (BYOD. In this article, we discuss BYOD’s background, prevalence, benefits, challenges, and possible security attacks. We then review contributions of academic researchers on BYOD. The Universiti Putra Malaysia online databases (such as IEEE Xplore digital library, Elsevier, Springer, ACM digital library were used to search for peer-reviewed academic publications and other relevant publications on BYOD. The Google Scholar search engine was also used. Our thorough review shows that security issues comprise the most significant challenge confronting BYOD policy and that very little has been done to tackle this security challenge. It is our hope that this review will provide a theoretical background for future research and enable researchers to identify researchable areas of BYOD.

  6. Bringing Technology into college and High School Physics Classrooms

    Science.gov (United States)

    Zettili, Nouredine

    2007-04-01

    We want to present ideas on ways of bringing technology to college and high school physics classrooms. We focus in particular on our outreach initiative in supporting a number of school districts with ways to improve high school physics education. This initiative is part of Project IMPACTSEED (IMproving Physics And Chemistry Teaching in SEcondary Education), a No-Child Left Behind grant funded by the Alabama Commission on Higher Education. This project is motivated by a major local need: A large number of high school physics teachers teach out of field. IMPACTSEED aims at helping high school teachers learn and master the various physics topics required by the Alabama course of study. Teachers are offered year-round support through a rich variety of programs: a two-week long summer institute, a series of five technology workshops, and onsite year-round support. Through our hands-on approach, we have identified a number of ways of bringing technology into physics classrooms. A number of technology projects were assigned to the teachers so as to show their students how physics connects to the technological devices around us. IMPACTSEED aims at providing our students with a physics education that enjoys continuity and consistency from high school to college.

  7. 24 CFR 26.18 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... knowledge of any discoverable matter. For good cause, the hearing officer may order discovery of any matter... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.18 Section 26.18... PROCEDURES Hearings Before Hearing Officers Discovery § 26.18 Discovery. (a) General. The parties...

  8. 43 CFR 4.1130 - Discovery methods.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery methods. 4.1130 Section 4.1130... Special Rules Applicable to Surface Coal Mining Hearings and Appeals Discovery § 4.1130 Discovery methods. Parties may obtain discovery by one or more of the following methods— (a) Depositions upon...

  9. 42 CFR 405.1037 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... original discovery deadline. (5) If the ALJ grants the extension request, it must impose a new discovery... 42 Public Health 2 2010-10-01 2010-10-01 false Discovery. 405.1037 Section 405.1037 Public Health... Appeals Under Original Medicare (Part A and Part B) Alj Hearings § 405.1037 Discovery. (a) General...

  10. 14 CFR 1264.120 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... PENALTIES ACT OF 1986 § 1264.120 Discovery. (a) The following types of discovery are authorized: (1... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Discovery. 1264.120 Section 1264.120..., discovery is available only as ordered by the presiding officer. The presiding officer shall regulate...

  11. 31 CFR 16.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.21 Discovery. (a) The following types of discovery are authorized... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 16.21 Section 16.21 Money... to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery...

  12. 38 CFR 42.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.21 Discovery. (a) The following types of discovery are... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Discovery. 42.21 Section... creation of a document. (c) Unless mutually agreed to by the parties, discovery is available only...

  13. International Conference Medical Radiations

    International Nuclear Information System (INIS)

    Full text : The second edition of the international conference Medical radiation : research and applications which took place in Marrakech (Morocco) from 7 to 9 April 2010, was designed to bring together researchers and physicians from different countries who dedicated their talents and time to this endeavour. The conference's program defined goals were is to identify the most reliable techniques among the several tested so far and to establish the most practical standardized methodologies, taking into account such recent technological development in radiation medical research. The scientific objectives of this conference are as follows : present the state of the art of the various topics of the congress, give a progress report on the impact of the interaction of the various scientific and technical disciplinary fields (Medicine, Biology, Mathematics, Physics,..) on the applications of radiations in medicine, promote the interdisciplinary efforts of research among researchers, present new technologies and research and development tasks prepared in the field of medical radiations, contribute to the emergence of new ideas of research and development of new collaborations

  14. Bringing home the health humanities: narrative humility, structural competency, and engaged pedagogy.

    Science.gov (United States)

    Tsevat, Rebecca K; Sinha, Anoushka A; Gutierrez, Kevin J; DasGupta, Sayantani

    2015-11-01

    As health humanities programs grow and thrive across the country, encouraging medical students to read, write, and become more reflective about their professional roles, educators must bring a sense of self-reflexivity to the discipline itself. In the health humanities, novels, patient histories, and pieces of reflective writing are often treated as architectural spaces or "homes" that one can enter and examine. Yet, narrative-based learning in health care settings does not always allow its participants to feel "at home"; when not taught with a critical attention to power and pedagogy, the health humanities can be unsettling and even dangerous. Educators can mitigate these risks by considering not only what they teach but also how they teach it.In this essay, the authors present three pedagogical pillars that educators can use to invite learners to engage more fully, develop critical awareness of medical narratives, and feel "at home" in the health humanities. These pedagogical pillars are narrative humility (an awareness of one's prejudices, expectations, and frames of listening), structural competency (attention to sources of power and privilege), and engaged pedagogy (the protection of students' security and well-being). Incorporating these concepts into pedagogical practices can create safe and productive classroom spaces for all, including those most vulnerable and at risk of being "unhomed" by conventional hierarchies and oppressive social structures. This model then can be translated through a parallel process from classroom to clinic, such that empowered, engaged, and cared-for learners become empowering, engaging, and caring clinicians. PMID:25945967

  15. Once Upon a Time ... Exhibition Science Bringing Nations Together

    CERN Document Server

    2000-01-01

    In 1956, a year and a half after the establishment of the European Organization for Nuclear Research, CERN, the states of the "socialist bloc" signed an agreement establishing a similar international centre for the study of fundamental problems in physics: the Joint Institute for Nuclear Research, JINR. The seat of the Institute was chosen to be the town of Dubna, 120 km north of Moscow. Though the establish-ment of JINR was clearly a political response, during the Cold War, to the establishment of CERN, from the very beginning the Institute's activities were aimed solely at investigating the fundamental properties of matter and using scientific discoveries for peaceful purposes.

  16. Comparative effectiveness research and medical informatics.

    Science.gov (United States)

    D'Avolio, Leonard W; Farwell, Wildon R; Fiore, Louis D

    2010-12-01

    As is the case for environmental, ecological, astronomical, and other sciences, medical practice and research finds itself in a tsunami of data. This data deluge, due primarily to the introduction of digitalization in routine medical care and medical research, affords the opportunity for improved patient care and scientific discovery. Medical informatics is the subdiscipline of medicine created to make greater use of information in order to improve healthcare. The 4 areas of medical informatics research (information access, structure, analysis, and interaction) are used as a framework to discuss the overlap in information needs of comparative effectiveness research and potential contributions of medical informatics. Examples of progress from the medical informatics literature and the Veterans Affairs Healthcare System are provided.

  17. The Europa Ocean Discovery mission

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others

    1997-06-01

    Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.

  18. A Mars Exploration Discovery Program

    Science.gov (United States)

    Hansen, C. J.; Paige, D. A.

    2000-07-01

    The Mars Exploration Program should consider following the Discovery Program model. In the Discovery Program a team of scientists led by a PI develop the science goals of their mission, decide what payload achieves the necessary measurements most effectively, and then choose a spacecraft with the capabilities needed to carry the payload to the desired target body. The primary constraints associated with the Discovery missions are time and money. The proposer must convince reviewers that their mission has scientific merit and is feasible. Every Announcement of Opportunity has resulted in a collection of creative ideas that fit within advertised constraints. Following this model, a "Mars Discovery Program" would issue an Announcement of Opportunity for each launch opportunity with schedule constraints dictated by the launch window and fiscal constraints in accord with the program budget. All else would be left to the proposer to choose, based on the science the team wants to accomplish, consistent with the program theme of "Life, Climate and Resources". A proposer could propose a lander, an orbiter, a fleet of SCOUT vehicles or penetrators, an airplane, a balloon mission, a large rover, a small rover, etc. depending on what made the most sense for the science investigation and payload. As in the Discovery program, overall feasibility relative to cost, schedule and technology readiness would be evaluated and be part of the selection process.

  19. Does Discovery-Based Instruction Enhance Learning?

    OpenAIRE

    Alfieri, L.; Brooks, PJ; Aldrich, NJ; Tenenbaum, HR

    2011-01-01

    Discovery learning approaches to education have recently come under scrutiny (Tobias & Duffy, 2009), with many studies indicating limitations to discovery learning practices. Therefore, 2 meta-analyses were conducted using a sample of 164 studies: The 1st examined the effects of unassisted discovery learning versus explicit instruction, and the 2nd examined the effects of enhanced and/or assisted discovery versus other types of instruction (e.g., explicit, unassisted discovery). Random effect...

  20. Mars Mapping Technology Brings Main Street to Life

    Science.gov (United States)

    2008-01-01

    The Red Planet has long held a particular hold on the human psyche. From the Roman god of war to Orson Welles infamous Halloween broadcast, our nearest planetary neighbor has been viewed with curiosity, suspicion, and awe. Pictures of Mars from 1965 to the present reveal familiar landscapes while also challenging our perceptions and revising our understanding of the processes at work in planets. Frequent discoveries have forced significant revisions to previous theories. Although Mars shares many familiar features with Earth, such as mountains, plains, valleys, and polar ice, the conditions on Mars can vary wildly from those with which we are familiar. The apparently cold, rocky, and dusty wasteland seen through the eyes of spacecraft and Martian probes hints at a dynamic past of volcanic activity, cataclysmic meteors, and raging waters. New discoveries continue to revise our view of our next-door neighbor, and further exploration is now paving the way for a human sortie to the fourth stone from the Sun. NASA s Mars Exploration Program, a long-term effort of robotic exploration, utilizes wide-angle stereo cameras mounted on NASA s twin robot geologists, the Mars Exploration Rovers (MERs), launched in 2003. The rovers, named "Spirit" and "Opportunity," celebrated 4 Earth years of exploration on January 3, 2008, and have sent back a wealth of information on the terrain and composition of the Martian surface. Their marathon performance has far outlasted the intended 90 days of operation, and the two intrepid explorers promise more images and data.

  1. Bringing international patients to American hospitals: the Johns Hopkins perspective.

    Science.gov (United States)

    Hutchins, J J

    1998-01-01

    American health care institutions are reaching out to the foreign market, assiduously cultivating patients from overseas. This innovative strategy, designed in part to help U.S. medical centers cope with cuts in federal funding, HMO pressures, and decreasing patient volumes, dovetails nicely with the current climate of global expansion in business and worldwide awareness of American medical expertise. This article describes the International Services Program at Johns Hopkins Hospital. The author and program director addresses its origins, implementation, outcomes, and the obstacles planners faced in launching a vigorous, international outreach initiative. PMID:10182529

  2. How much more cost sharing will health savings accounts bring?

    Science.gov (United States)

    Remler, Dahlia K; Glied, Sherry A

    2006-01-01

    Proponents of health savings accounts (HSAs) contend that they will reduce medical expenditures. In practice, however, the effect of HSAs, and the high-deductible health plans that must accompany them, will depend on the actual provisions of those plans and of the plans they replace. We show that typical plans in the market today already contain substantial cost sharing. We find that many HSA/high-deductible arrangements would actually reduce cost sharing for many groups. In particular, the group responsible for half of all medical spending would see no change or a decline in cost sharing at the margin and on average. PMID:16835188

  3. Discovery of the higgs boson

    CERN Document Server

    Sharma, Vivek

    2016-01-01

    The recent observation of the Higgs boson has been hailed as the scientific discovery of the century and led to the 2013 Nobel Prize in physics. This book describes the detailed science behind the decades-long search for this elusive particle at the Large Electron Positron Collider at CERN and at the Tevatron at Fermilab and its subsequent discovery and characterization at the Large Hadron Collider at CERN. Written by physicists who played leading roles in this epic search and discovery, this book is an authoritative and pedagogical exposition of the portrait of the Higgs boson that has emerged from a large number of experimental measurements. As the first of its kind, this book should be of interest to graduate students and researchers in particle physics.

  4. Supporting knowledge discovery in medicine.

    Science.gov (United States)

    Girardi, Dominic; Arthofer, Klaus

    2014-01-01

    Our ontology-based benchmarking infrastructure for hospitals, we presented on the eHealth 2012, has meanwhile proven useful. Besides, we gathered manifold experience in supporting knowledge discovery in medicine. This also led to further functions and plans with our software. We could confirm and extent our experience by a literature review on the knowledge discovery process in medicine, visual analytics and data mining and drafted an according approach for extending our software. We validated our approach by exemplarily implementing a parallel-coordinate data visualization into our software and plan to integrate further algorithms for visual analytics and machine learning to support knowledge discovery in medicine in diverse ways. This is very promising but can also fail due to technical or organizational details.

  5. Towards structural web services discovery

    Institute of Scientific and Technical Information of China (English)

    CHEN Jiang-feng

    2008-01-01

    A syntactic and structural matching mechanism for service discovery was put forward, which tries to exploit the underlying semantics of web services to enhance the traditional syntactic service discovery. We commit WSDL (Web Service Description Language) as service description language. The syntactic matching mechanism is based on the textual similarity among WSDL documents using VSM (Vector Space Model). The structural information is extracted from WSDL document tree or the invocation sequence of a series of services which can be viewed as the problem of graph isomorphism. Then we combine the syntactic and structural similarity linearly to calculate the service similarity. Finally we provide a novel web services discovery framework named SG* to find the exact services meeting the users' goals based on service similarity.

  6. Archaeopteryx: Bringing the Dino-Bird to Life

    Energy Technology Data Exchange (ETDEWEB)

    Bergmann, Uwe

    2011-01-25

    Some 150 million years ago, a strange creature died in a tropical lagoon that today is located in Bavaria, Germany. In 1861, a single feather of this creature was discovered. Not long afterward, a complete fossil was found with the same bird-like feathers but dinosaur-like anatomical features. Darwin had just published 'On the Origin of Species'; could this be the missing link that Darwin's supporters hoped to find? Recently, two of the now eleven discovered Archaeopteryx fossils, and that first feather, were brought to SLAC, where, using the intense X-ray beam, researchers searched for the chemical remains of the original living creatures. Please join us for this lecture, which will explain how the studies attempt to bring the original dino-bird back to life.

  7. Bringing Science into Schools through Astronomy. Project ASTRO, Tucson

    CERN Document Server

    Barban, C; Barban, Caroline; Dole, Herve

    2005-01-01

    We report our experience in bringing science into US and French classrooms. We participated in the US scientific educational program Project ASTRO. It is based on a partnership between a school teacher and an astronomer. They together design and realize simple and interesting scientific activities for the children to learn and enjoy science. We present four hands-on activities we realized in a 4th-grade class (10 yr-old kids) in Tucson (USA) in 2002-2003. Among the covered topics were: the Solar System, the Sun (helioseismology) and the Galaxies. We also present a similar experience done in two classrooms in 2005, in Chatenay-Malabry (France) in partnership with an amateur astronomy association (Aphelie). This is a pleasant and rewarding activity, extremely well appreciated by the children and the school teachers. It furthermore promotes already at a young age the excitement of science, and provides concrete examples of the scientific methodology.

  8. Mathematical models in biology bringing mathematics to life

    CERN Document Server

    Ferraro, Maria; Guarracino, Mario

    2015-01-01

    This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy.  The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content...

  9. Bringing the power of dynamic languages to hardware control systems

    CERN Document Server

    Caicedo, J M; Neufeld, N

    2009-01-01

    Hardware control systems are normally programmed using high-performance languages like C or C++ and increasingly also Java. All these languages are strongly typed and compiled which brings usually good performance but at the cost of a longer development and testing cycle and the need for more programming expertise. Dynamic languages which were long thought to be too slow and not powerful enough for control purposes are, thanks to modern powerful computers and advanced implementation techniques, fast enough for many of these tasks. We present examples from the LHCb Experiment Control System (ECS), which is based on a commercial SCADA software. We have successfully used Python to integrate hardware devices into the ECS. We present the necessary lightweight middle-ware we have developed, including examples for controlling hardware and software devices. We also discuss the development cycle, tools used and compare the effort to traditional solutions.

  10. Bringing history to life: simulating landmark experiments in psychology.

    Science.gov (United States)

    Boynton, David M; Smith, Laurence D

    2006-05-01

    The course in history of psychology can be challenging for students, many of whom enter it with little background in history and faced with unfamiliar names and concepts. The sheer volume of material can encourage passive memorization unless efforts are made to increase student involvement. As part of a trend toward experiential history, historians of science have begun to supplement their lectures with demonstrations of classic physics experiments as a way to bring the history of science to life. Here, the authors report on computer simulations of five landmark experiments from early experimental psychology in the areas of reaction time, span of attention, and apparent motion. The simulations are designed not only to permit hands-on replication of historically important results but also to reproduce the experimental procedures closely enough that students can gain a feel for the nature of early research and the psychological processes being studied. PMID:17152604

  11. Medical Journalism and Emergency Medicine

    Directory of Open Access Journals (Sweden)

    Saeed Safari

    2015-07-01

    Full Text Available Nowadays, many researches in the field of medicine are conducting all around the world and medical journalism is a way to share the results. In fact, dissemination of the related manuscripts can prevent the repetitive research or may even lead to conducting a better survey. Therefore high quality medical journals are considered as up-to-date resources for further investigations. Medical journals are propagating their papers in various media including television programs, newspapers, internet websites and different social media. So they can influence the government policy makers, health-care professionals and even public. Moreover, most researchers hear about medical discoveries for the first time through medical journals and their related social media. So as well a high quality journal can help to improve medical science, a journal of poor quality can be damaging and distorting. Indeed, popular journals have the power of inventing a “communication storm” to draw attention to a certain topic. Thus they have to respect the accepted international principles to prevent spreading inaccurate and misleading data. This paper aims to review the previous and current situation of medical journalism by focus on field of emergency medicine.

  12. Knowledge discovery from legal databases

    CERN Document Server

    Stranieri, Andrew; Schauer, Frederick

    2006-01-01

    Knowledge Discovery from Legal Databases is the first text to describe data mining techniques as they apply to law. Law students, legal academics and applied information technology specialists are guided thorough all phases of the knowledge discovery from databases process with clear explanations of numerous data mining algorithms including rule induction, neural networks and association rules. Throughout the text, assumptions that make data mining in law quite different to mining other data are made explicit.  Issues such as the selection of commonplace cases, the use of discretion as a form

  13. ASSESSMENT OF THE EDUCATIONAL ENVIRONMENT AMONG MEDICAL UNDERGRADUATE STUDENTS IN A GOVERNMENT MEDICAL COLLEGE

    OpenAIRE

    Ramamurthy; Lilian D; Ranganath; Arun Mohan

    2014-01-01

    BACKGROUND: The improved health of all people is the ultimate goal of medical education. Every student works hard to get into the best educational institution in order to pursue a competent career. Every institution has its core objective as imparting high standards of education and bringing out well trained students. The environment in which a student learns and grows is crucial to the overall development. AIM: To assess the perceptions of medical students of their educat...

  14. Knowledge Discovery/A Collaborative Approach, an Innovative Solution

    Science.gov (United States)

    Fitts, Mary A.

    2009-01-01

    Collaboration between Medical Informatics and Healthcare Systems (MIHCS) at NASA/Johnson Space Center (JSC) and the Texas Medical Center (TMC) Library was established to investigate technologies for facilitating knowledge discovery across multiple life sciences research disciplines in multiple repositories. After reviewing 14 potential Enterprise Search System (ESS) solutions, Collexis was determined to best meet the expressed needs. A three month pilot evaluation of Collexis produced positive reports from multiple scientists across 12 research disciplines. The joint venture and a pilot-phased approach achieved the desired results without the high cost of purchasing software, hardware or additional resources to conduct the task. Medical research is highly compartmentalized by discipline, e.g. cardiology, immunology, neurology. The medical research community at large, as well as at JSC, recognizes the need for cross-referencing relevant information to generate best evidence. Cross-discipline collaboration at JSC is specifically required to close knowledge gaps affecting space exploration. To facilitate knowledge discovery across these communities, MIHCS combined expertise with the TMC library and found Collexis to best fit the needs of our researchers including:

  15. Multimodal medical information retrieval with unsupervised rank fusion.

    Science.gov (United States)

    Mourão, André; Martins, Flávio; Magalhães, João

    2015-01-01

    Modern medical information retrieval systems are paramount to manage the insurmountable quantities of clinical data. These systems empower health care experts in the diagnosis of patients and play an important role in the clinical decision process. However, the ever-growing heterogeneous information generated in medical environments poses several challenges for retrieval systems. We propose a medical information retrieval system with support for multimodal medical case-based retrieval. The system supports medical information discovery by providing multimodal search, through a novel data fusion algorithm, and term suggestions from a medical thesaurus. Our search system compared favorably to other systems in 2013 ImageCLEFMedical.

  16. TU-C-BRF-01: Innovation in Medical Physics and Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Mohan, R [UT MD Anderson Cancer Center, Houston, TX (United States); Pelc, N [Stanford University, Stanford, CA (United States); Jaffray, D [Princess Margaret Hospital, Toronto, ON (Canada); Mackie, T [University of Wisconsin, Madison, WI (United States)

    2014-06-15

    We seek to heighten the awareness of the role of research and innovation that leads to clinical advances in the field of medical physics and engineering. Marie Curie (discovery and use of radium) and Harold Johns (Co-60 tele-therapy) in radiotherapy, and pioneers in imaging (Allan Cormack and Godfrey Hounsfield for the CT and Paul Lauterbur, Peter Mansfield for MRI, etc.) were scientists often struggling against great odds. Examples of more recent innovations that are clearly benefitting our patients include IMRT, Image Guided Radiation Therapy and Surgery, Particle Therapy, Quantitative imaging, amongst others.We would also like to highlight the fact that not all of the discovery and engineering that we benefit from in today’s world, was performed at research institutions alone. Rather, companies often tread new ground at financial and reputational risk. Indeed the strength of the private sector is needed in order to bring about new advances to our practice. The keys to long term success in research and development may very well include more public and private research spending. But, when more investigators are funded, we also need to recognize that there needs to be a willingness on the part of the funding institutions, academic centers and investigators to risk failure for the greater potential achievements in innovation and research. The speakers will provide examples and insight into the fields of innovation and research in medical physics from their own first hand experiences. Learning Objectives: To obtain an understanding of the importance of research and development towards advances in physics in medicine. To raise awareness of the role of interdisciplinary collaborations in translational research and innovation. To highlight the importance of entrepreneurships and industrial-institutional research partnerships in fostering new ideas and their commercial success. To recognize and account for the risk of failure for the greater potential achievements in

  17. Press conference bring excitement of geophysical research to the public

    Science.gov (United States)

    Leifert, Harvey

    “A Flare to Remember.” “Starbucks for Starfish.” “Earth's Rotation Slows for El Niño.” What do these catchy headlines have in common? They all resulted from presentations at AGU's Spring Meeting in Boston, Mass. Yes, geophysical science can be big news when presented in a way that is interesting to general audiences.Proof? Well, the “Flare to Remember” headline (in the Dallas Morning News) reported the discovery, via the SOHO spacecraft, that a solar flare had produced, deep inside the Sun, seismic disturbances of a magnitude never experienced on Earth. Researchers Valentina Zharkova of Glasgow University and Alexander Kosovichev of Stanford gave media representatives a preview of their session, supported by visual aids, in the AGU press briefing room.

  18. Medical imaging technology

    CERN Document Server

    Haidekker, Mark A

    2013-01-01

    Biomedical imaging is a relatively young discipline that started with Conrad Wilhelm Roentgen’s discovery of the x-ray in 1885. X-ray imaging was rapidly adopted in hospitals around the world. However, it was the advent of computerized data and image processing that made revolutionary new imaging modalities possible. Today, cross-sections and three-dimensional reconstructions of the organs inside the human body is possible with unprecedented speed, detail and quality. This book provides an introduction into the principles of image formation of key medical imaging modalities: X-ray projection imaging, x-ray computed tomography, magnetic resonance imaging, ultrasound imaging, and radionuclide imaging. Recent developments in optical imaging are also covered. For each imaging modality, the introduction into the physical principles and sources of contrast is provided, followed by the methods of image formation, engineering aspects of the imaging devices, and a discussion of strengths and limitations of the modal...

  19. Smartphones: A Potential Discovery Tool

    OpenAIRE

    Starkweather, Wendy; Stowers, Eva

    2009-01-01

    The anticipated wide adoption of smartphones by researchers is viewed by the authors as a basis for developing mobile-based services. In response to the UNLV Libraries’ strategic plan’s focus on experimentation and outreach, the authors investigate the current and potential role of smartphones as a valuable discovery tool for library users.

  20. Antibody informatics for drug discovery

    DEFF Research Database (Denmark)

    Shirai, Hiroki; Prades, Catherine; Vita, Randi;

    2014-01-01

    for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...

  1. Structural Biology Guides Antibiotic Discovery

    Science.gov (United States)

    Polyak, Steven

    2014-01-01

    Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…

  2. Macchines per scoprire - Discovery Machines

    CERN Multimedia

    Auditorium, Rome

    2016-01-01

    During the FCC week 2016 a public event entitled “Discovery Machines: The Higgs Boson and the Search for New Physics took place on 14 April at the Auditorium in Rome. The event, brought together physicists and experts from economics to discuss intriguing questions on the origin and evolution of the Universe and the societal impact of large-scale research projects.

  3. SHAPE-BASED TIME SERIES SIMILARITY MEASURE AND PATTERN DISCOVERY ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Zeng Fanzi; Qiu Zhengding; Li Dongsheng; Yue Jianhai

    2005-01-01

    Pattern discovery from time series is of fundamental importance. Most of the algorithms of pattern discovery in time series capture the values of time series based on some kinds of similarity measures. Affected by the scale and baseline, value-based methods bring about problem when the objective is to capture the shape. Thus, a similarity measure based on shape, Sh measure, is originally proposed, andthe properties of this similarity and corresponding proofs are given. Then a time series shape pattern discovery algorithm based on Sh measure is put forward. The proposed algorithm is terminated in finite iteration with given computational and storage complexity. Finally the experiments on synthetic datasets and sunspot datasets demonstrate that the time series shape pattern algorithm is valid.

  4. EarthObserver: Bringing the world to your fingertips

    Science.gov (United States)

    Ryan, W. B.; Goodwillie, A. M.; Coplan, J.; Carbotte, S. M.; Arko, R. A.; Ferrini, V.; O'hara, S. H.; Chan, S.; Bonczkowski, J.; Nitsche, F. O.; Morton, J. J.; McLain, K.; Weissel, R.

    2011-12-01

    EarthObserver (http://www.earth-observer.org/), developed by the Lamont-Doherty Earth Observatory of Columbia University, brings a wealth of geoscience data to Apple iPad, iPhone and iPod Touch mobile devices. Built around an easy-to-use interface, EarthObserver allows users to explore and visualise a wide range of data sets superimposed upon a detailed base map of land elevations and ocean depths - tapping the screen will instantly return the height or depth at that point. A simple transparency function allows direct comparison of built-in content. Data sets include high-resolution coastal bathymetry of bays, sounds, estuaries, harbors and rivers; geological maps of the US states and world - tapping the screen displays the rock type, and full legends can be viewed; US Topo sheets; and, geophysical content including seafloor crustal age and sediment thickness, earthquake and volcano data, gravity and magnetic anomalies, and plate boundary descriptions. The names of physiographic features are automatically displayed. NASA Visible Earth images along with ocean temperature, salinity and productivity maps and precipitation information expose data sets of interest to the atmospheric, oceanic and biological communities. Natural hazard maps, population information and political boundaries allow users to explore impacts upon society. EarthObserver, so far downloaded by more than 55,000 users, offers myriad ways for educators at all levels to bring research-quality geoscience data into the learning environment, whether for use as an in-class illustration or for extensive exploration of earth sciences data. By using cutting-edge mobile app technology, EarthObserver boosts access to relevant earth science content. The EarthObserver base map is the Global Multi-Resolution Topography digital elevation model (GMRT; http://www.marine-geo.org/portals/gmrt/), also developed at LDEO and updated regularly. It provides land elevations with horizontal resolution as high as 10m for

  5. Research for the soldier: bringing science fiction medicine to life.

    Science.gov (United States)

    Lam, David M; Curley, Kenneth C

    2006-08-01

    Through means of a science fiction vignette, this paper presents and discusses many of the current research projects ongoing to enable the U.S. military medical services to provide an outstanding level of care in future conflicts. The research capabilities and programs of the U.S. Army Telemedicine and Advanced Technology Research Center (TATRC) are discussed, as are the partnerships between the TATRC and its collaborating researchers.

  6. Spin-off from Research Exhibition Science Bringing Nations Together

    CERN Multimedia

    2000-01-01

    The purpose of fundamental research in physics is to discover the laws of Nature. The results of this research become available to all mankind, allowing breakthroughs in high technology and in the development of human civilization. Modern physics makes a decisive contribution to such highly important areas as cancer treatment, medical applications of nuclear detectors, computer tomography, World Wide Web, safe nuclear power, and many others.

  7. Nursing leadership: bringing caring back to the future

    OpenAIRE

    Kitson, A.

    2001-01-01

    Leadership, whether it is nursing, medical or healthcare leadership, is about knowing how to make visions become reality. The vision that many nurses hold dear to their hearts is one where patients are treated with dignity and respect at all times; where systems are designed for the benefit of individual needs; and where the work performed by nurses and other carers is valued and respected. Achieving such a vision will require a paradigm shift in the philosophy, priorities, policies, and powe...

  8. Conceptualising International Peace Mediation - Bring Back the Law

    OpenAIRE

    Higgins, Noelle; Daly, Brenda

    2011-01-01

    Mediation has been acknowledged and utilised for a number of decades as an effective method of alternative dispute resolution in a variety of areas of law, including family law, commercial law and medical law. A uniform, standardised framework exists within legal discourse which clearly identifies and categorises three main styles of mediation as facilitative, evaluative and transformative mediation. In the post-Cold War period, mediation has also emerged as an important resolution tool in ar...

  9. Cardiac Medications

    Science.gov (United States)

    ... for Medication For the treatment of heart failure Beta Blockers (Also known as Beta-Adrenergic Blocking Agents) Commonly ... have had a heart attack. Combined alpha and beta-blockers Combined alpha and beta-blockers are used as ...

  10. Medical marijuana

    Science.gov (United States)

    ... 18. Other people who should not use medical marijuana include: People with heart disease Pregnant women People with a history of psychosis Other concerns linked to marijuana use include: Dangerous driving or other risky behaviors ...

  11. Medication Guide

    Science.gov (United States)

    ... Size Small Text Medium Text Large Text Contrast Dark on Light Light on Dark Donate Search Menu Donate What is Glaucoma? Care ... Low Vision Resources Medication Guide Resources on the Web » See All Articles Help the Cause Glaucoma affects ...

  12. Medical education.

    Science.gov (United States)

    Krishnan, P

    1992-01-01

    In theory, the Medical Council of India (MCI) determines the standards and qualifications of medical schools. It also sanctions curricula and ensures standards. Yet no standards exist on the mode of selection in medical schools, duration of study, course content, student stipends or period of internship. It takes 4.5 years to finish medical school. Students undergo preclinical, paraclinical, and clinical training. Most courses are in English which tends to favor the urban elite. Students cannot always communicate with patients in local languages. Textbooks often provide medical examples unrelated to India. Pedagogy consists mainly of lectures and rote learning predominates. Curricula tend not to provide courses in community health. Students pick up on the elitist attitudes of the faculty. For example, faculty do not put much emphasis on community health, individual health, equity in health care delivery, and teamwork. Further the education system is not patient oriented, but hospital or disease oriented. Faculty should train students in creating sanitation programs, knowing local nutritious foods, and in making community diagnoses. Yet they tend to be practitioners 1st then educators. Further faculty are not paid well and are not always invited to take part in improving curriculum, so morale is often low. Moreover experience in health planning and management issues is not required for administrators. In addition, medical schools are not well equipped with learning aids, libraries, or teaching staff. Tax revenues finance medical education. 75% of graduating physicians set up a private practice. Further many physicians go to urban areas. 34-57% emigrate to other countries. The problems of medical education will not be solved until the political and economic system becomes more responsive to the health needs of the people.

  13. Medical tourism

    OpenAIRE

    Abbas Ghanbari; Khadijeh Zirak Moradlu; Morteza Ramazani

    2014-01-01

    Medical tourism is considered as one of the tourism dimensions and it can contribute to the stabilized and dynamic development of a country's economy. Since it is cost-effective industry, most developing countries have focused on this industry and they are planning to develop this industry. Not only does Zanjan province, as the central region in medicine services, enjoy different kinds of variety and acceptable medical specialties but also it has historical, natural, and religious tourism pot...

  14. Medical Image Analysis Facility

    Science.gov (United States)

    1978-01-01

    To improve the quality of photos sent to Earth by unmanned spacecraft. NASA's Jet Propulsion Laboratory (JPL) developed a computerized image enhancement process that brings out detail not visible in the basic photo. JPL is now applying this technology to biomedical research in its Medical lrnage Analysis Facility, which employs computer enhancement techniques to analyze x-ray films of internal organs, such as the heart and lung. A major objective is study of the effects of I stress on persons with heart disease. In animal tests, computerized image processing is being used to study coronary artery lesions and the degree to which they reduce arterial blood flow when stress is applied. The photos illustrate the enhancement process. The upper picture is an x-ray photo in which the artery (dotted line) is barely discernible; in the post-enhancement photo at right, the whole artery and the lesions along its wall are clearly visible. The Medical lrnage Analysis Facility offers a faster means of studying the effects of complex coronary lesions in humans, and the research now being conducted on animals is expected to have important application to diagnosis and treatment of human coronary disease. Other uses of the facility's image processing capability include analysis of muscle biopsy and pap smear specimens, and study of the microscopic structure of fibroprotein in the human lung. Working with JPL on experiments are NASA's Ames Research Center, the University of Southern California School of Medicine, and Rancho Los Amigos Hospital, Downey, California.

  15. Innovations in higher medical education

    Directory of Open Access Journals (Sweden)

    Popkov V.M.

    2014-03-01

    Full Text Available The article is devoted to the innovations in the higher medical education. Particular attention in this sphere is paid to the detailed analysis of the subject as a mechanism of cognition and psycho-emotional aspect. It should be noticed that the development of the university education demands the integration of functional systems to study the general medicine and the art of healing. In conclusion it has been found out that the new methodological approach is necessary to bring the teacher closer to the subject particularly to integrate the relation of the opposites.

  16. Demarketing fear: Bring the nuclear issue back to rational discourse

    International Nuclear Information System (INIS)

    This paper attempts to explore the strategies for breaking the deadlock between the demand for resolving climate crisis and the resistance to deploying nuclear power. Since our present renewable technology is not advanced enough to replace fossil fuel power plants, nuclear power becomes the only available means that can buy us more time to explore better energy sources for coping with the dilemma of global warming and energy security. Therefore, this paper proposes an elaborated fear appeal framework that may shed light on the intervention points for mitigating fear. By examining the influence of fear appeal on the nuclear issue, three strategies for demarketing the nuclear fear of the public are recommended. The paper concludes that only when energy policy makers and the nuclear industry recognize the significance of minimizing fear and begin to work on removing the sources of fear, can we then expect to bring the nuclear issue back to rational discourse. - Highlights: • Both cognition and emotion are critical in decision-making processes. • Dealing with the emotion of fear is essential for resolving the nuclear issue. • Fear should be mitigated to make rational discourses on nuclear power happen. • Fear can be mitigated by manipulating issue familiarity and response feasibility. • Using equivalency and issue framing may alter public perceptions of nuclear power

  17. Geodesy Brings the Geoscience Community Together as Geophysicists

    Science.gov (United States)

    Kittross, S.; Rowan, L. R.; MacPherson-Krutsky, C. C.; Morris, A. R.; Bartel, B. A.

    2015-12-01

    Geodesy, the science of determining Earth's shape, gravity field and rotation, has been in existence for millennia. Today, few geoscientists identify with the pure science of geodesy, though many use geodetic tools and data for their research. In 2014, we interviewed members of the UNAVCO community and asked, "Do you call yourself a geodesist?" Most replied that they used geodesy, but would call themselves "geophysicists". This "use of geodesy" for other fields of study, particularly for geophysics-related fields, is consistent with an analysis of AGU's sections and focus groups. Additional analysis of geoscience departments at U.S. universities would suggest a similar trend. The expanding use of geodetic tools and geodetic data for many fields of research such as geophysics, tectonophysics, geodynamics, space physics, geology, geomorphology, seismology, hydrology, volcanology, glaciology, paleontology, paleoseismology, structural geology, meteorology, ecology, archaeology, oceanography, geography, soil science, atmospheric science, and snow science, may provide an approach to bringing diverse fields together under the moniker of geoscience and geoscientists. Scientists using a shared approach to research and education might be able to see themselves under the broader identity of geoscientist. The hurdle to making this transformation towards a larger shared voice in public discourse, is the more common use of "geophysicist" among the geodesy community, which is tied to the strong foundation of physics and mathematics needed to work with geodetic data and tools.

  18. Bringing Western-standard service stations to the Baltic countries

    International Nuclear Information System (INIS)

    Neste is the only Western oil company so far to have established a service station presence in the Baltic, with the exception of Norway's Statoil, which has one outlet near Tallinn Airport. Neste has an important logistical advantage compared to other companies in this respect as its two Finnish refineries are ideally located for supplying the region with high-quality petroleum products. Neste's first joint venture in the Baltic, Traffic Service, based in Estonia, was set up with Eesti Kutus in 1988 and opened its first service station in 1990. Other joint ventures are now up and running in Latvia, Lithuania, Poland, and St. Petersburg. A total of 10 - 15 stations, the majority strategically located along the route of the Via Baltica, are expected to be operational by the end of this year. The Neste network comprises a combination of new outlets and refurbished older stations that have been modernized to bring them up to Western standards. These offer a comprehensive range of fuels, lubricants, spare parts, and accessories, as well as food, confectionery, and coffee shop services. Some stations also offer repair and car wash facilities. Adapting to the transition from a communist economy to a Western, capitalist one has not been easy for the Baltic countries, and has inevitably created difficulties for companies like Neste, in areas such as legislation covering land ownership. Neste's joint ventures have also encountered difficulties in instilling the Western approach to business efficiency, and customer service in a workforce used to the Soviet retail system

  19. Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.

    Science.gov (United States)

    Zhang, Yi; Schulten, Klaus; Gruebele, Martin; Bansal, Paramjit S; Wilson, David; Daly, Norelle L

    2016-04-26

    Disulfide bridges are commonly found covalent bonds that are usually believed to maintain structural stability of proteins. Here, we investigate the influence of disulfide bridges on protein dynamics through molecular dynamics simulations on the cysteine-rich trypsin inhibitor MCoTI-II with three disulfide bridges. Correlation analysis of the reduced cyclic peptide shows that two of the three disulfide distances (Cys(11)-Cys(23) and Cys(17)-Cys(29)) are anticorrelated within ∼1 μs of bridge formation or dissolution: when the peptide is in nativelike structures and one of the distances shortens to allow bond formation, the other tends to lengthen. Simulations over longer timescales, when the denatured state is less structured, do not show the anticorrelation. We propose that the native state contains structural elements that frustrate one another's folding, and that the two bridges are critical for snapping the frustrated native structure into place. In contrast, the Cys(4)-Cys(21) bridge is predicted to form together with either of the other two bridges. Indeed, experimental chromatography and nuclear magnetic resonance data show that an engineered peptide with the Cys(4)-Cys(21) bridge deleted can still fold into its near-native structure even in its noncyclic form, confirming the lesser role of the Cys(4)-Cys(21) bridge. The results highlight the importance of disulfide bridges in a small bioactive peptide to bring together frustrated structure in addition to maintaining protein structural stability. PMID:27119635

  20. 5 CFR 185.122 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... § 185.122 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... document or of the truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b)...

  1. 24 CFR 26.42 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... subject to a protective order under § 26.44. (c) Authorized discovery. The following types of discovery... or of the truth of any relevant matters of fact. Copies of documents shall be delivered with...

  2. 40 CFR 27.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for... truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b) For the purpose...

  3. 22 CFR 224.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... document or the truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b) For...

  4. 15 CFR 25.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for... truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b) For the purpose...

  5. Discovery of charmed particles : Sam Ting

    CERN Multimedia

    1974-01-01

    The great physics event of the year was the discovery of charmed particles in the USA. One of the co-discoverers, Sam Ting, was at CERN involved in an ISR experiment and described the discovery to a packed auditorium.

  6. Integrative systems biology for data-driven knowledge discovery.

    Science.gov (United States)

    Greene, Casey S; Troyanskaya, Olga G

    2010-09-01

    Integrative systems biology is an approach that brings together diverse high-throughput experiments and databases to gain new insights into biological processes or systems at molecular through physiological levels. These approaches rely on diverse high-throughput experimental techniques that generate heterogeneous data by assaying varying aspects of complex biological processes. Computational approaches are necessary to provide an integrative view of these experimental results and enable data-driven knowledge discovery. Hypotheses generated from these approaches can direct definitive molecular experiments in a cost-effective manner. By using integrative systems biology approaches, we can leverage existing biological knowledge and large-scale data to improve our understanding of as yet unknown components of a system of interest and how its malfunction leads to disease.

  7. [The discovery of blood circulation: revolution or revision?].

    Science.gov (United States)

    Crignon, Claire

    2011-01-01

    The discovery of the principle of blood circulation by William Harvey is generally considered as one of the major events of the "scientific revolution" of the 17th century. This paper reconsiders the question by taking in account the way Harvey's discovery was discussed by some contemporary philosophers and physicians, in particular Fontenelle, who insisted on the necessity of redefining methods and principles of medical knowledge, basing themselves on the revival of anatomy and physiology, and of its consequences on the way it permits to think about the human nature. This return allows us to consider the opportunity of substituting the kuhnian scheme of "structure of scientific revolutions" for the bachelardian concept of "refonte".

  8. Nanoinformatics knowledge infrastructures: bringing efficient information management to nanomedical research

    Science.gov (United States)

    de la Iglesia, D.; Cachau, R. E.; García-Remesal, M.; Maojo, V.

    2013-01-01

    Nanotechnology represents an area of particular promise and significant opportunity across multiple scientific disciplines. Ongoing nanotechnology research ranges from the characterization of nanoparticles and nanomaterials to the analysis and processing of experimental data seeking correlations between nanoparticles and their functionalities and side effects. Due to their special properties, nanoparticles are suitable for cellular-level diagnostics and therapy, offering numerous applications in medicine, e.g. development of biomedical devices, tissue repair, drug delivery systems and biosensors. In nanomedicine, recent studies are producing large amounts of structural and property data, highlighting the role for computational approaches in information management. While in vitro and in vivo assays are expensive, the cost of computing is falling. Furthermore, improvements in the accuracy of computational methods (e.g. data mining, knowledge discovery, modeling and simulation) have enabled effective tools to automate the extraction, management and storage of these vast data volumes. Since this information is widely distributed, one major issue is how to locate and access data where it resides (which also poses data-sharing limitations). The novel discipline of nanoinformatics addresses the information challenges related to nanotechnology research. In this paper, we summarize the needs and challenges in the field and present an overview of extant initiatives and efforts.

  9. Nanoinformatics knowledge infrastructures: bringing efficient information management to nanomedical research

    Science.gov (United States)

    de la Iglesia, D; Cachau, R E; García-Remesal, M; Maojo, V

    2014-01-01

    Nanotechnology represents an area of particular promise and significant opportunity across multiple scientific disciplines. Ongoing nanotechnology research ranges from the characterization of nanoparticles and nanomaterials to the analysis and processing of experimental data seeking correlations between nanoparticles and their functionalities and side effects. Due to their special properties, nanoparticles are suitable for cellular-level diagnostics and therapy, offering numerous applications in medicine, e.g. development of biomedical devices, tissue repair, drug delivery systems and biosensors. In nanomedicine, recent studies are producing large amounts of structural and property data, highlighting the role for computational approaches in information management. While in vitro and in vivo assays are expensive, the cost of computing is falling. Furthermore, improvements in the accuracy of computational methods (e.g. data mining, knowledge discovery, modeling and simulation) have enabled effective tools to automate the extraction, management and storage of these vast data volumes. Since this information is widely distributed, one major issue is how to locate and access data where it resides (which also poses data-sharing limitations). The novel discipline of nanoinformatics addresses the information challenges related to nanotechnology research. In this paper, we summarize the needs and challenges in the field and present an overview of extant initiatives and efforts. PMID:24932210

  10. Nanoinformatics knowledge infrastructures: bringing efficient information management to nanomedical research

    International Nuclear Information System (INIS)

    Nanotechnology represents an area of particular promise and significant opportunity across multiple scientific disciplines. Ongoing nanotechnology research ranges from the characterization of nanoparticles and nanomaterials to the analysis and processing of experimental data seeking correlations between nanoparticles and their functionalities and side effects. Due to their special properties, nanoparticles are suitable for cellular-level diagnostics and therapy, offering numerous applications in medicine, e.g. development of biomedical devices, tissue repair, drug delivery systems and biosensors. In nanomedicine, recent studies are producing large amounts of structural and property data, highlighting the role for computational approaches in information management. While in vitro and in vivo assays are expensive, the cost of computing is falling. Furthermore, improvements in the accuracy of computational methods (e.g. data mining, knowledge discovery, modeling and simulation) have enabled effective tools to automate the extraction, management and storage of these vast data volumes. Since this information is widely distributed, one major issue is how to locate and access data where it resides (which also poses data-sharing limitations). The novel discipline of nanoinformatics addresses the information challenges related to nanotechnology research. In this paper, we summarize the needs and challenges in the field and present an overview of extant initiatives and efforts. (paper)

  11. Does Discovery-Based Instruction Enhance Learning?

    Science.gov (United States)

    Alfieri, Louis; Brooks, Patricia J.; Aldrich, Naomi J.; Tenenbaum, Harriet R.

    2011-01-01

    Discovery learning approaches to education have recently come under scrutiny (Tobias & Duffy, 2009), with many studies indicating limitations to discovery learning practices. Therefore, 2 meta-analyses were conducted using a sample of 164 studies: The 1st examined the effects of unassisted discovery learning versus explicit instruction, and the…

  12. 12 CFR 19.170 - Discovery depositions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Discovery depositions. 19.170 Section 19.170... PROCEDURE Discovery Depositions and Subpoenas § 19.170 Discovery depositions. (a) General rule. In any... deposition of an expert, or of a person, including another party, who has direct knowledge of matters...

  13. 29 CFR 1955.32 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 1955.32 Section 1955.32 Labor Regulations...) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.32 Discovery... the remainder. An answering party may not give lack of information or knowledge as the reason...

  14. 29 CFR 18.13 - Discovery methods.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Discovery methods. 18.13 Section 18.13 Labor Office of the... ADMINISTRATIVE LAW JUDGES General § 18.13 Discovery methods. Parties may obtain discovery by one or more of the following methods: Depositions upon oral examination or written questions; written...

  15. 28 CFR 71.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Discovery. 71.21 Section 71.21...

  16. 22 CFR 521.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Discovery. 521.21 Section 521.21 Foreign Relations BROADCASTING BOARD OF GOVERNORS IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 521.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents...

  17. 43 CFR 4.826 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... the Interior-Effectuation of Title VI of the Civil Rights Act of 1964 Procedures § 4.826 Discovery. (a) Methods. Parties may obtain discovery as provided in these rules by depositions, written interrogatories... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery. 4.826 Section 4.826...

  18. 7 CFR 1.322 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2... 7 Agriculture 1 2010-01-01 2010-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office...

  19. 29 CFR 1905.25 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.25 Discovery. (a) Depositions. (1) For reasons of... 29 Labor 5 2010-07-01 2010-07-01 false Discovery. 1905.25 Section 1905.25 Labor Regulations... discovery. Whenever appropriate to a just disposition of any issue in a hearing, the presiding...

  20. 20 CFR 355.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ... UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Discovery. 355.21 Section 355.21...

  1. Discovery in Science and in Teaching Science

    Science.gov (United States)

    Kipnis, Nahum

    2007-01-01

    A proper presentation of scientific discoveries may allow science teachers to eliminate certain myths about the nature of science, which originate from an uncertainty among scholars about what constitutes a discovery. It is shown that a disagreement on this matter originates from a confusion of the act of discovery with response to it. It is…

  2. Glycoscience aids in biomarker discovery

    Directory of Open Access Journals (Sweden)

    Serenus Hua1,2 & Hyun Joo An1,2,*

    2012-06-01

    Full Text Available The glycome consists of all glycans (or carbohydrates within abiological system, and modulates a wide range of important biologicalactivities, from protein folding to cellular communications.The mining of the glycome for disease markers representsa new paradigm for biomarker discovery; however, this effortis severely complicated by the vast complexity and structuraldiversity of glycans. This review summarizes recent developmentsin analytical technology and methodology as applied tothe fields of glycomics and glycoproteomics. Mass spectrometricstrategies for glycan compositional profiling are described, as arepotential refinements which allow structure-specific profiling.Analytical methods that can discern protein glycosylation at aspecific site of modification are also discussed in detail.Biomarker discovery applications are shown at each level ofanalysis, highlighting the key role that glycoscience can play inhelping scientists understand disease biology.

  3. Materials discovery via CALYPSO methodology

    Science.gov (United States)

    Wang, Yanchao; Lv, Jian; Zhu, Li; Lu, Shaohua; Yin, Ketao; Li, Quan; Wang, Hui; Zhang, Lijun; Ma, Yanming

    2015-05-01

    The structure prediction at the atomic level is emerging as a state-of-the-art approach to accelerate the functionality-driven discovery of materials. By combining the global swarm optimization algorithm with first-principles thermodynamic calculations, it exploits the power of current supercomputer architectures to robustly predict the ground state and metastable structures of materials with only the given knowledge of chemical composition. In this Review, we provide an overview of the basic theory and main features of our as-developed CALYPSO structure prediction method, as well as its versatile applications to design of a broad range of materials including those of three-dimensional bulks, two-dimensional reconstructed surfaces and layers, and isolated clusters/nanoparticles or molecules with a variety of functional properties. The current challenges faced by structure prediction for materials discovery and future developments of CALYPSO to overcome them are also discussed.

  4. Class Discovery in Galaxy Classification

    CERN Document Server

    Bazell, D; Bazell, David; Miller, David J.

    2004-01-01

    In recent years, automated, supervised classification techniques have been fruitfully applied to labeling and organizing large astronomical databases. These methods require off-line classifier training, based on labeled examples from each of the (known) object classes. In practice, only a small batch of labeled examples, hand-labeled by a human expert, may be available for training. Moreover, there may be no labeled examples for some classes present in the data, i.e. the database may contain several unknown classes. Unknown classes may be present due to 1) uncertainty in or lack of knowledge of the measurement process, 2) an inability to adequately ``survey'' a massive database to assess its content (classes), and/or 3) an incomplete scientific hypothesis. In recent work, new class discovery in mixed labeled/unlabeled data was formally posed, with a proposed solution based on mixture models. In this work we investigate this approach, propose a competing technique suitable for class discovery in neural network...

  5. Medical migration.

    Science.gov (United States)

    Loefler, I J

    2001-10-01

    The issue of professional migration, however emotional it may have become, ought not to be regarded in moralizing terms. The history of western medicine is the history of migrating physicians. A doctor who moves from a locality to another to take up a new assignment there cannot be said to have "abandoned his patients". This emotional bond has become the victim of specialization and of depersonalization of medical services and not of medical migration, brain drain or otherwise. The primary reason for medical migration is not financial; the desire to migrate usually begins with the desire to learn. Professionals crave in the first line for professional satisfaction. The migration of medical manpower cannot be stopped with administrative measures and will not be stopped by exhortations and appeals, moralization and condemnations. Brain drain is a global phenomenon and has always been so. A country which loses its professionals, its doctors, should examine the social relationships within the profession and should investigate whether the opportunities for deriving professional satisfaction from everyday work exist or whether these have been thwarted by the hierarchy, conservatism, cronyism and the general lack of comprehension of what good medical care is about. PMID:11593497

  6. Medical Renaissance.

    Science.gov (United States)

    Toledo-Pereyra, Luis H

    2015-06-01

    The Medical Renaissance started as the regular Renaissance did in the early 1400s and ended in the late 1600s. During this time great medical personalities and scholar humanists made unique advances to medicine and surgery. Linacre, Erasmus, Leonicello and Sylvius will be considered first, because they fit the early classic Renaissance period. Andreas Vesalius and Ambroise Paré followed thereafter, making outstanding anatomical contributions with the publication of the "Human Factory" (1543) by Vesalius, and describing unique surgical developments with the publication of the "The Apologie and Treatise of Ambroise Paré." At the end of the Renaissance and beginning of the New Science, William Harvey, noted British medical doctor and cardiovascular researcher, discovered the general circulation. He published his findings in "The Motu Cordis" in 1628 (Figure 1). The Medical Renaissance, in summary, included a great number of accomplished physicians and surgeons who made especial contributions to human anatomy; Vesalius assembled detailed anatomical information; Paré advanced surgical techniques; and Harvey, a medical genius, detailed the circulatory anatomy and physiology.

  7. Developing and understanding a hospital-based proton facility: bringing physics into medicine.

    Science.gov (United States)

    Slater, James M

    2007-08-01

    From October 18 to 20, 2006, a symposium, Developing and Understanding a Hospital-based Proton Facility: Bringing Physics Into Medicine, was held at the Renaissance Esmeralda Resort and Spa, Indian Wells, California. The event was offered by the Department of Radiation Medicine at Loma Linda University (LLU), supported by the Telemedicine and Advanced Technology Research Center (TATRC) and the United States Army Medical Research and Materiel Command (USAMRMC). The meeting was intended to discuss factors involved in planning, developing, and operating a hospital-based proton treatment center. It brought together some of the most distinguished physicists, radiation biologists, and radiation oncologists in the world, and more than 100 individuals participated in the three-day educational offering. This overview reports on the event and introduces several papers written by many of the speakers from their presentations, for publication in this issue of Technology in Cancer Research and Treatment. Both the symposium and the papers are appropriate for this journal: exploitation of technology was one of the underlying themes of the symposium.

  8. Metagenomic small molecule discovery methods

    OpenAIRE

    Charlop-Powers, Zachary; Milshteyn, Aleksandr; Brady, Sean F

    2014-01-01

    Metagenomic approaches to natural product discovery provide the means of harvesting bioactive small molecules synthesized by environmental bacteria without the requirement of first culturing these organisms. Advances in sequencing technologies and general metagenomic methods are beginning to provide the tools necessary to unlock the unexplored biosynthetic potential encoded by the genomes of uncultured environmental bacteria. Here, we highlight recent advances in sequence- and functional- bas...

  9. Gas reserves, discoveries and production

    Energy Technology Data Exchange (ETDEWEB)

    Saniere, A

    2006-07-01

    Between 2000 and 2004, new discoveries, located mostly in the Asia/Pacific region, permitted a 71% produced reserve replacement rate. The Middle East and the offshore sector represent a growing proportion of world gas production Non-conventional gas resources are substantial but are not exploited to any significant extent, except in the United States, where they account for 30% of U.S. gas production. (author)

  10. Towards Discovery of Subgraph Bisociations

    OpenAIRE

    Nagel, Uwe; Thiel, Kilian; Kötter, Tobias; Piatek, Dawid; Berthold, Michael R

    2012-01-01

    The discovery of surprising relations in large, heterogeneous information repositories is gaining increasing importance in real world data analysis. If these repositories come from diverse origins, forming different domains, domain bridging associations between otherwise weakly connected domains can provide insights into the data that are not accomplished by aggregative approaches. In this paper, we propose a first formalization for the detection of such potentially interesting, domaincrossin...

  11. Gender equity and tobacco control: bringing masculinity into focus.

    Science.gov (United States)

    Morrow, Martha; Barraclough, Simon

    2010-03-01

    Gender is a key but often overlooked--determinant of tobacco use, especially in Asia, where sex-linked differences in prevalence rates are very large. In this article we draw upon existing data to consider the implications of these patterns for gender equity and propose approaches to redress inequity through gender-sensitive tobacco control activities. International evidence demonstrates that, in many societies, risk behaviours (including tobacco use) are practised substantially more by men and boys, and are also viewed as expressions of masculine identity. While gender equity focuses almost exclusively on the relative disadvantage of girls and women that exists in most societies, disproportionate male use of tobacco has profound negative consequences for men (as users) and for women (nonusers). Surprisingly, health promotion and tobacco control literature rarely focus on the role of gender in health risks among boys and men. However, tobacco industry marketing has masterfully incorporated gender norms, and also other important cultural values, to ensure its symbols are context-specific. By addressing gender-specific risks within the local cultural context--as countries are enjoined to do within the Framework Convention's Guiding Principles--it may be possible to accelerate the impact of mechanisms such as tobacco pricing, restrictions on marketing, smoking bans and provision of accurate information. It is essential that we construct a new research-to-policy framework for gender-sensitive tobacco control. Successful control of tobacco can only be strengthened by bringing males, and the concept of gender as social construction, back into our research and discussion on health and gender equity. PMID:20595351

  12. Equity and what secondary science teachers bring to the classroom

    Science.gov (United States)

    Austin, Barbara Anne

    The demographics of people working in science-based careers do not match the demographics of the larger society. In particular, people who self-identify as Hispanic are underrepresented among working scientists. One reason may be the influence of formal schooling and more specifically, the behaviors of teachers in secondary science classrooms. This study looks at the practices of eight secondary science teachers at two schools at which 62% of the enrolled students declare their ethnicity as Hispanic. All of the teachers have at least three years of experience. Through interviews with the teachers, classroom observation, and interviews with other faculty, this research elucidates typical behaviors and attitudes surrounding teaching science in these settings. In spite of having a deficit view of their students, they all express interest in and concern about the students they teach. Their characterizations of teaching practices and classroom behaviors do not incorporate strategies designed to promote content learning through culturally relevant curriculum. Instead, they use mainstream-situated approaches that develop science content knowledge, vocabulary, procedures, and skills targeted toward high achievement on state and district standardized tests leading toward graduation or success in college. These approaches are consistent with a view of equity that increases the participation of underrepresented groups in science based careers in that it gives students the skills and knowledge they will need in order to successfully pursue these careers. Additionally, they behave in ways that are consistent with equitable strategies such as using inquiry based teaching, serving as role models, and providing a structured learning environment. This research informs the literature base for instructional systems designers by identifying what that teachers situated in culturally diverse classrooms bring to professional development programs targeted toward making secondary science

  13. Who's bringing you hot ideas and how are you responding?

    Science.gov (United States)

    Davenport, Thomas H; Prusak, Laurence; Wilson, H James

    2003-02-01

    There's an unsung hero in your organization. It's the person who's bringing in new ideas from the outside about how to manage better. These aren't your product and service innovators--those people are celebrated loudly and often. This is the manager who, for instance, first uttered the phrase "balance scorecard" in your hallways, or "real options," or "intellectual capital." Managerial innovation is an increasingly important source of competitive advantage--especially given the speed with which product innovations are copied--but it doesn't happen automatically. It takes a certain kind of person to welcome new management ideas and usher them into an organization. The authors recently studied 100 such people to find out how they translate new ideas into action in their organizations. They discovered that they are a distinct type of practitioner; that is to say, they resemble their counterparts in other organizations more than they resemble their own colleagues, and they share a common way of working. "Idea practitioners," as the authors call them, begin by scouting for ideas. All of them are avid readers of management literature and enthusiastic participants in business conferences; many are friendly with business gurus. Once they've identified an idea that seems to hold promise, they tailor it to fit their organizations' specific needs. Next, they actively sell the idea--to senior executives, to the rank and file, to middle managers. And finally, they get the ball rolling by participating in small-scale experiments. But when those take off, they get out of the way and let others execute. In this article, the authors identify the characteristics of idea practitioners and offer strategies for managing them wisely.

  14. Optimizing Viral Discovery in Bats.

    Science.gov (United States)

    Young, Cristin C W; Olival, Kevin J

    2016-01-01

    Viral discovery studies in bats have increased dramatically over the past decade, yet a rigorous synthesis of the published data is lacking. We extract and analyze data from 93 studies published between 2007-2013 to examine factors that increase success of viral discovery in bats, and specific trends and patterns of infection across host taxa and viral families. Over the study period, 248 novel viruses from 24 viral families have been described. Using generalized linear models, at a study level we show the number of host species and viral families tested best explained number of viruses detected. We demonstrate that prevalence varies significantly across viral family, specimen type, and host taxonomy, and calculate mean PCR prevalence by viral family and specimen type across all studies. Using a logistic model, we additionally identify factors most likely to increase viral detection at an individual level for the entire dataset and by viral families with sufficient sample sizes. Our analysis highlights major taxonomic gaps in recent bat viral discovery efforts and identifies ways to improve future viral pathogen detection through the design of more efficient and targeted sample collection and screening approaches. PMID:26867024

  15. A New Universe of Discoveries

    Science.gov (United States)

    Córdova, France A.

    2016-01-01

    The convergence of emerging advances in astronomical instruments, computational capabilities and talented practitioners (both professional and civilian) is creating an extraordinary new environment for making numerous fundamental discoveries in astronomy, ranging from the nature of exoplanets to understanding the evolution of solar systems and galaxies. The National Science Foundation is playing a critical role in supporting, stimulating, and shaping these advances. NSF is more than an agency of government or a funding mechanism for the infrastructure of science. The work of NSF is a sacred trust that every generation of Americans makes to those of the next generation, that we will build on the body of knowledge we inherit and continue to push forward the frontiers of science. We never lose sight of NSF's obligation to "explore the unexplored" and inspire all of humanity with the wonders of discovery. As the only Federal agency dedicated to the support of basic research and education in all fields of science and engineering, NSF has empowered discoveries across a broad spectrum of scientific inquiry for more than six decades. The result is fundamental scientific research that has had a profound impact on our nation's innovation ecosystem and kept our nation at the very forefront of the world's science-and-engineering enterprise.

  16. Prediction of breast cancer survival through knowledge discovery in databases.

    Science.gov (United States)

    Lotfnezhad Afshar, Hadi; Ahmadi, Maryam; Roudbari, Masoud; Sadoughi, Farahnaz

    2015-01-26

    The collection of large volumes of medical data has offered an opportunity to develop prediction models for survival by the medical research community. Medical researchers who seek to discover and extract hidden patterns and relationships among large number of variables use knowledge discovery in databases (KDD) to predict the outcome of a disease. The study was conducted to develop predictive models and discover relationships between certain predictor variables and survival in the context of breast cancer. This study is Cross sectional. After data preparation, data of 22,763 female patients, mean age 59.4 years, stored in the Surveillance Epidemiology and End Results (SEER) breast cancer dataset were analyzed anonymously. IBM SPSS Statistics 16, Access 2003 and Excel 2003 were used in the data preparation and IBM SPSS Modeler 14.2 was used in the model design. Support Vector Machine (SVM) model outperformed other models in the prediction of breast cancer survival. Analysis showed SVM model detected ten important predictor variables contributing mostly to prediction of breast cancer survival. Among important variables, behavior of tumor as the most important variable and stage of malignancy as the least important variable were identified. In current study, applying of the knowledge discovery method in the breast cancer dataset predicted the survival condition of breast cancer patients with high confidence and identified the most important variables participating in breast cancer survival.

  17. Medical tourism

    Directory of Open Access Journals (Sweden)

    Abbas Ghanbari

    2014-08-01

    Full Text Available Medical tourism is considered as one of the tourism dimensions and it can contribute to the stabilized and dynamic development of a country's economy. Since it is cost-effective industry, most developing countries have focused on this industry and they are planning to develop this industry. Not only does Zanjan province, as the central region in medicine services, enjoy different kinds of variety and acceptable medical specialties but also it has historical, natural, and religious tourism potentials. In this survey, the researcher investigated the existing potentials of Zanjan province based on descriptive - analytical tourism in offering and providing medical services and accommodation. The survey reports that offered services in tourism were not acceptable and satisfactory.

  18. Medical emplotment

    DEFF Research Database (Denmark)

    Mønsted, Troels Sune

    ’. Theoretically the project departs from Computer Supported Cooperative Work and Participatory Design and is informed by Medical Informatics, Design Research and Science and Technology Studies. Methodically the project is founded on collaborative prototyping, ethnographic studies, and design interventions...... philosophy and building on theory on narrative reasoning, the dissertation offers the notions of emplotment and re-emplotment to describe how physicians marshal information from various sources, including the medical record, the patient and coSummary to form a narrative, when making sense of patients...

  19. Medical Applications

    CERN Document Server

    Biscari, C

    2014-01-01

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on CNAO, and the report closes with a brief outlook on the future of this field.

  20. Medical leasing.

    Science.gov (United States)

    Holden, Elizabeth A

    2012-01-01

    Leases for medical space can have far-reaching (and sometimes unintentional) consequences for the future of the practice and the costs of the business. In order to prevent hardship and expense down the line, it is especially important to review the lease to make sure that it reflects the practice's goals, needs, and structure. This article provides a number of provisions that are especially crucial to review and negotiate when leasing medical space, including use restrictions, assignment and subleasing clauses, build-out terms, and legal compliance requirements. PMID:22594070

  1. Medical leasing.

    Science.gov (United States)

    Holden, Elizabeth A

    2012-01-01

    Leases for medical space can have far-reaching (and sometimes unintentional) consequences for the future of the practice and the costs of the business. In order to prevent hardship and expense down the line, it is especially important to review the lease to make sure that it reflects the practice's goals, needs, and structure. This article provides a number of provisions that are especially crucial to review and negotiate when leasing medical space, including use restrictions, assignment and subleasing clauses, build-out terms, and legal compliance requirements.

  2. DISCOVERY

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    新产品 国际家居品牌石家庄勒泰中心店盛大开幕近日,国际时尚家饰家用品牌HOLA特力和乐石家庄首店盛大开幕,正式入驻位于中山路核心商圈的勒泰购物中心。HOLA将以优质精品家居和贴心的服务,

  3. Medical entomology--back to the future?

    Science.gov (United States)

    Reisen, William K

    2014-12-01

    Some of problems and challenges facing Medical/Veterinary Entomology are presented from my perspective, focusing on the current millennium. Topics include anthropogenic environmental changes created by population growth, administrative problems hindering science's response to these changes, and some of the scientific discoveries potentially providing solutions. As the title implies, many recent research discoveries have yet to be translated into major changes in control approaches for the major vectorborne public health problems, thereby providing an interesting mix of modern surveillance technology used to track problems and direct historical intervention solutions.

  4. Method and Application of Comprehensive Knowledge Discovery

    Institute of Scientific and Technical Information of China (English)

    SHA Zongyao; BIAN Fuling

    2003-01-01

    This paper proposes the principle of comprehensive knowledge discovery. Unlike most of the current knowledge discovery methods, the comprehensive knowledge discovery considers both the spatial relations and attributes of spatial entities or objects. We introduce the theory of spatial knowledge expression system and some concepts including comprehensive knowledge discovery and spatial union information table(SUIT). In theory, SUIT records all information contained in the studied objects, but in reality, because of the complexity and varieties of spatial relations,only those factors of interest to us are selected. In order to find out the comprehensive knowledge from spatial databases, an efficient comprehensive knowledge discovery algorithm called recycled algorithm (RAR) is suggested.

  5. Future clinical trials in DIPG: bringing epigenetics to the clinic

    Directory of Open Access Journals (Sweden)

    Andres E. Morales La Madrid

    2015-07-01

    Full Text Available In spite of major recent advances in DIPG molecular characterization, this body of knowledge has not yet translated into better treatments.To date,more than 250 clinical trials evaluating radiotherapy along with conventional cytotoxic chemotherapy as well as newer biologic agents,have failed to improve the dismal outcome when compared to palliative radiation alone.The biology of DIPG remained unknown until recently when the neurosurgical expertise along with the recognition by the scientific and clinical community of the importance of tissue sampling at diagnosis;ideally in the context of a clinical trial and by trained neurosurgical teams to maximize patient safety.These pre-treatment tumor samples,and others coming from tissue obtained post-mortem,have yielded new insights into DIPG molecular biology.We now know that DIPG comprises a heterogeneous disease with variable molecular phenotypes, different from adult high grade glioma,other non-pontine pediatric high grade gliomas and even between pontine gliomas.The discovery of histone H3.3 or H3.1 mutations has been an important step forward in understanding tumor formation,maintenance and progression.Pharmacologic reversal of DIPG histone demethylation therefore offers an important potential intervention strategy for the treatment of DIPG.To date,clinical trials of newly diagnosed or progressive DIPG with epigenetic modifiers have been unsuccessful.Whether this failure represents limited activity of the agents used,their CNS penetration,redundant pathways within the tumor,or the possibility that histone mutations are necessary only to initiate DIPGs but not maintain their growth,suggest that a great deal still needs to be elucidated in both the underlying biology of these pathways,and the drugs designed to target them.In this review, we discuss the role of both epigenetic and genetic mutations within DIPG and the development of treatment strategies directed against the unique abnormalities

  6. Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Science.gov (United States)

    Okada, Yukinori; Wu, Di; Trynka, Gosia; Raj, Towfique; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Yoshida, Shinji; Graham, Robert R.; Manoharan, Arun; Ortmann, Ward; Bhangale, Tushar; Denny, Joshua C.; Carroll, Robert J.; Eyler, Anne E.; Greenberg, Jeffrey D.; Kremer, Joel M.; Pappas, Dimitrios A.; Jiang, Lei; Yin, Jian; Ye, Lingying; Su, Ding-Feng; Yang, Jian; Xie, Gang; Keystone, Ed; Westra, Harm-Jan; Esko, Tõnu; Metspalu, Andres; Zhou, Xuezhong; Gupta, Namrata; Mirel, Daniel; Stahl, Eli A.; Diogo, Dorothée; Cui, Jing; Liao, Katherine; Guo, Michael H.; Myouzen, Keiko; Kawaguchi, Takahisa; Coenen, Marieke J.H.; van Riel, Piet L.C.M.; van de Laar, Mart A.F.J.; Guchelaar, Henk-Jan; Huizinga, Tom W.J.; Dieudé, Philippe; Mariette, Xavier; Bridges, S. Louis; Zhernakova, Alexandra; Toes, Rene E.M.; Tak, Paul P.; Miceli-Richard, Corinne; Bang, So-Young; Lee, Hye-Soon; Martin, Javier; Gonzalez-Gay, Miguel A.; Rodriguez-Rodriguez, Luis; Rantapää-Dahlqvist, Solbritt; Ärlestig, Lisbeth; Choi, Hyon K.; Kamatani, Yoichiro; Galan, Pilar; Lathrop, Mark; Eyre, Steve; Bowes, John; Barton, Anne; de Vries, Niek; Moreland, Larry W.; Criswell, Lindsey A.; Karlson, Elizabeth W.; Taniguchi, Atsuo; Yamada, Ryo; Kubo, Michiaki; Liu, Jun S.; Bae, Sang-Cheol; Worthington, Jane; Padyukov, Leonid; Klareskog, Lars; Gregersen, Peter K.; Raychaudhuri, Soumya; Stranger, Barbara E.; De Jager, Philip L.; Franke, Lude; Visscher, Peter M.; Brown, Matthew A.; Yamanaka, Hisashi; Mimori, Tsuneyo; Takahashi, Atsushi; Xu, Huji; Behrens, Timothy W.; Siminovitch, Katherine A.; Momohara, Shigeki; Matsuda, Fumihiko; Yamamoto, Kazuhiko; Plenge, Robert M.

    2013-01-01

    A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological datasets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA)1. Here, we performed a genome-wide association study (GWAS) meta-analysis in a total of >100,000 subjects of European and Asian ancestries (29,880 RA cases and 73,758 controls), by evaluating ~10 million single nucleotide polymorphisms (SNPs). We discovered 42 novel RA risk loci at a genome-wide level of significance, bringing the total to 1012–4. We devised an in-silico pipeline using established bioinformatics methods based on functional annotation5, cis-acting expression quantitative trait loci (cis-eQTL)6, and pathway analyses7–9 – as well as novel methods based on genetic overlap with human primary immunodeficiency (PID), hematological cancer somatic mutations and knock-out mouse phenotypes – to identify 98 biological candidate genes at these 101 risk loci. We demonstrate that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. Together, this comprehensive genetic study sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis, and provides empirical evidence that the genetics of RA can provide important information for drug discovery. PMID:24390342

  7. Genetics of rheumatoid arthritis contributes to biology and drug discovery.

    Science.gov (United States)

    Okada, Yukinori; Wu, Di; Trynka, Gosia; Raj, Towfique; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Yoshida, Shinji; Graham, Robert R; Manoharan, Arun; Ortmann, Ward; Bhangale, Tushar; Denny, Joshua C; Carroll, Robert J; Eyler, Anne E; Greenberg, Jeffrey D; Kremer, Joel M; Pappas, Dimitrios A; Jiang, Lei; Yin, Jian; Ye, Lingying; Su, Ding-Feng; Yang, Jian; Xie, Gang; Keystone, Ed; Westra, Harm-Jan; Esko, Tõnu; Metspalu, Andres; Zhou, Xuezhong; Gupta, Namrata; Mirel, Daniel; Stahl, Eli A; Diogo, Dorothée; Cui, Jing; Liao, Katherine; Guo, Michael H; Myouzen, Keiko; Kawaguchi, Takahisa; Coenen, Marieke J H; van Riel, Piet L C M; van de Laar, Mart A F J; Guchelaar, Henk-Jan; Huizinga, Tom W J; Dieudé, Philippe; Mariette, Xavier; Bridges, S Louis; Zhernakova, Alexandra; Toes, Rene E M; Tak, Paul P; Miceli-Richard, Corinne; Bang, So-Young; Lee, Hye-Soon; Martin, Javier; Gonzalez-Gay, Miguel A; Rodriguez-Rodriguez, Luis; Rantapää-Dahlqvist, Solbritt; Arlestig, Lisbeth; Choi, Hyon K; Kamatani, Yoichiro; Galan, Pilar; Lathrop, Mark; Eyre, Steve; Bowes, John; Barton, Anne; de Vries, Niek; Moreland, Larry W; Criswell, Lindsey A; Karlson, Elizabeth W; Taniguchi, Atsuo; Yamada, Ryo; Kubo, Michiaki; Liu, Jun S; Bae, Sang-Cheol; Worthington, Jane; Padyukov, Leonid; Klareskog, Lars; Gregersen, Peter K; Raychaudhuri, Soumya; Stranger, Barbara E; De Jager, Philip L; Franke, Lude; Visscher, Peter M; Brown, Matthew A; Yamanaka, Hisashi; Mimori, Tsuneyo; Takahashi, Atsushi; Xu, Huji; Behrens, Timothy W; Siminovitch, Katherine A; Momohara, Shigeki; Matsuda, Fumihiko; Yamamoto, Kazuhiko; Plenge, Robert M

    2014-02-20

    A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological data sets to provide insight into disease pathogenesis and guide drug discovery for complex traits such as rheumatoid arthritis (RA). Here we performed a genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries (29,880 RA cases and 73,758 controls), by evaluating ∼10 million single-nucleotide polymorphisms. We discovered 42 novel RA risk loci at a genome-wide level of significance, bringing the total to 101 (refs 2 - 4). We devised an in silico pipeline using established bioinformatics methods based on functional annotation, cis-acting expression quantitative trait loci and pathway analyses--as well as novel methods based on genetic overlap with human primary immunodeficiency, haematological cancer somatic mutations and knockout mouse phenotypes--to identify 98 biological candidate genes at these 101 risk loci. We demonstrate that these genes are the targets of approved therapies for RA, and further suggest that drugs approved for other indications may be repurposed for the treatment of RA. Together, this comprehensive genetic study sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis, and provides empirical evidence that the genetics of RA can provide important information for drug discovery. PMID:24390342

  8. Replication, Communication, and the Population Dynamics of Scientific Discovery.

    Directory of Open Access Journals (Sweden)

    Richard McElreath

    Full Text Available Many published research results are false (Ioannidis, 2005, and controversy continues over the roles of replication and publication policy in improving the reliability of research. Addressing these problems is frustrated by the lack of a formal framework that jointly represents hypothesis formation, replication, publication bias, and variation in research quality. We develop a mathematical model of scientific discovery that combines all of these elements. This model provides both a dynamic model of research as well as a formal framework for reasoning about the normative structure of science. We show that replication may serve as a ratchet that gradually separates true hypotheses from false, but the same factors that make initial findings unreliable also make replications unreliable. The most important factors in improving the reliability of research are the rate of false positives and the base rate of true hypotheses, and we offer suggestions for addressing each. Our results also bring clarity to verbal debates about the communication of research. Surprisingly, publication bias is not always an obstacle, but instead may have positive impacts-suppression of negative novel findings is often beneficial. We also find that communication of negative replications may aid true discovery even when attempts to replicate have diminished power. The model speaks constructively to ongoing debates about the design and conduct of science, focusing analysis and discussion on precise, internally consistent models, as well as highlighting the importance of population dynamics.

  9. Discovery Mondays: 'The Grid: a universal computer'

    CERN Multimedia

    2006-01-01

    How can one store and analyse the 15 million billion pieces of data that the LHC will produce each year with a computer that isn't the size of a sky-scraper? The IT experts have found the answer: the Grid, which will harness the power of tens of thousands of computers in the world by putting them together on one network and making them work like a single computer achieving a power that has not yet been matched. The Grid, inspired from the Web, already exists - in fact, several of them exist in the field of science. The European EGEE project, led by CERN, contributes not only to the study of particle physics but to medical research as well, notably in the study of malaria and avian flu. The next Discovery Monday invites you to explore this futuristic computing technology. The 'Grid Masters' of CERN have prepared lively animations to help you understand how the Grid works. Children can practice saving the planet on the Grid video game. You will also discover other applications such as UNOSAT, a United Nations...

  10. Medication Errors

    Science.gov (United States)

    ... Proprietary Names (PDF - 146KB) Draft Guidance for Industry: Best Practices in Developing Proprietary Names for Drugs (PDF - 279KB) ... or (301) 796-3400 druginfo@fda.hhs.gov Human Drug ... in Medication Errors Resources for You Agency for Healthcare Research and Quality: ...

  11. Kaiserschnitten Wien - Let's bring the forest in the city

    Directory of Open Access Journals (Sweden)

    Ajda Primožič

    2012-01-01

    Full Text Available The location is part of the Vienna River Valley, known as "Wiental", one of the most dissonant, incongruous, and contested areas of Vienna. Depending on one’s perspective, the Vienna River Valley can be viewed as a transit corridor, an unresolved urban area, an urban interface, an inter- zone, an infrastructure bundle, an ugly wound in the urban landscape, a socially charged boundary, etc. We started the project with urban pattern analyses on different scales: the scale of the city, the scale of Wiental (from Schönbrunn to Hofburg and on a minor scale, i.e. the scale of the project.The analysis showed that Wiental constitutes the main connection between the city centre and suburbia and the countryside in the background of the city. With its clear morphological importance, it could become a green axis of the city, a pleasant place for people, rather than having only an infrastructural role. Our concept is to bring new character to Wiental by making it a pedestrian- and cyclist-friendly green axis. Our initial goal was to reduce car traffic. We proposed introducing a park-and-ride system, which would become a point of transfer where car traffic is replaced by public transport and cycle traffic. Through the afforestation of Wiental, the area could become a park or recreational route, and the quality of life in the area would improve.An important aspect of the project was dealing with the Danube. We proposed to manage the flood peaks by introducing a dam, and after the point of regulation, we arranged the River into two levels: an ambient upper flow and infrastructural lower flow in the existing channel. Also, by rearranging "Naschmarkt" with the Danube uncovered, we predicted an extension of tourism from the city centre to Schönbrunn by bicycle or on foot, which could be followed by an expansion of the public programme. We wanted to show that the Danube, with an appropriate environment, could become a significant element of the city structure.

  12. ISSLIVE! Bringing the Space Station to Every Generation

    Science.gov (United States)

    Harris, Philip D.; Price, Jennifer B.; Severance, Mark; Blue, Regina; Khan, Ahmed; Healy, Matthew D.; Ehlinger, Jesse B.

    2011-01-01

    traditional education system, ISSLive! provides a single, interactive, and engaging experience to learn about the ISS and its role in space exploration, international collaboration, and science. While traditional students are using ISSLive! in the classroom, their parents, grandparents, and friends are using it at home. ISSLive! truly brings the daily operations of the ISS into the daily lives of the public from every generation.

  13. Designer drugs: the evolving science of drug discovery.

    Science.gov (United States)

    Wanke, L A; DuBose, R F

    1998-07-01

    Drug discovery and design are fundamental to drug development. Until recently, most drugs were discovered through random screening or developed through molecular modification. New technologies are revolutionizing this phase of drug development. Rational drug design, using powerful computers and computational chemistry and employing X-ray crystallography, nuclear magnetic resonance spectroscopy, and three-dimensional quantitative structure activity relationship analysis, is creating highly specific, biologically active molecules by virtual reality modeling. Sophisticated screening technologies are eliminating all but the most active lead compounds. These new technologies promise more efficacious, safe, and cost-effective medications, while minimizing drug development time and maximizing profits. PMID:10185235

  14. Guided Discovery with Socratic Questioning

    Directory of Open Access Journals (Sweden)

    M. Hakan TURKCAPAR

    2015-03-01

    Full Text Available “The Socratic method” is a way of teaching philosophical thinking and knowledge by asking questions. It was first used by in ancient times by the Greek philosopher Socrates who taught his followers by asking questions; these conversations between them are known as “Socratic dialogues”. In this methodology, no new knowledge is taught to the individual; rather, the individual is guided to remember and rediscover what was formerly known through this process. The main method used in cognitive therapy is guided discovery. There are various methods of guided discovery in cognitive therapy. The form of verbal exchange between the therapist and client which is used during the process of cognitive behavioral therapy is known as “socratic questioning”. In this method the goal is to make the client rediscover, with a series of questions, a piece of knowledge which he could otherwise know but is not presently conscious of. The Socratic Questioning consists of several steps, including: identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly rediscovered information and questioning the old distorted belief, and reaching a new conclusion and applying it. Question types used during these procedures are: questions for collecting information, questions revealing meanings, questions revealing beliefs, questions about behaviours during similar past experiences, analytic questions and analytic synthesis questions. In order to make the patient feel understood, it is important to be empathetic and summarize the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues provided for each step.

  15. Discovery of a Makemakean Moon

    Science.gov (United States)

    Parker, Alex H.; Buie, Marc W.; Grundy, Will M.; Noll, Keith S.

    2016-07-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope’s Wide Field Camera 3 on UTC 2015 April 27 at 7.80 ± 0.04 mag fainter than Makemake and at a separation of 0.″57. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days and must have a semimajor axis ≳21,000 km. We find that the properties of Makemake’s moon suggest that the majority of the dark material detected in the system by thermal observations may not reside on the surface of Makemake, but may instead be attributable to S/2015 (136472) 1 having a uniform dark surface. This “dark moon hypothesis” can be directly tested with future James Webb Space Telescope observations. We discuss the implications of this discovery for the spin state, figure, and thermal properties of Makemake and the apparent ubiquity of trans-Neptunian dwarf planet satellites.

  16. Discovery of Uniformly Expanding Universe

    OpenAIRE

    Cahill R. T.; Rothall D.

    2012-01-01

    Saul Perlmutter and the Brian Schmidt – Adam Riess teams reported that their Friedmann-model GR-based analysis of their supernovae magnitude-redshift data re- vealed a new phenomenon of “dark energy” which, it is claimed, forms 73% of the energy / matter density of the present-epoch universe, and which is linked to the further claim of an accelerating expansion of the universe. In 2011 Perlmutter, Schmidt and Riess received the Nobel Prize in Physics “for the discovery of...

  17. Discovery of Interstellar Heavy Water

    OpenAIRE

    Butner, H. M.; Charnley, S. B.; Ceccarelli, C.; Rodgers, S.D.; Pardo Carrión, Juan Ramón; Parise, B.; Cernicharo, José; Davis, G. R.

    2007-01-01

    We report the discovery of doubly deuterated water (D2O, heavy water) in the interstellar medium. Using the James Clerk Maxwell Telescope and the Caltech Submillimeter Observatory 10 m telescope, we detected the 1_10–1_01 transition of para-D2O at 316.7998 GHz in both absorption and emission toward the protostellar binary system IRAS 16293-2422. Assuming that the D2O exists primarily in the warm regions where water ices have been evaporated (i.e., in a "hot corino" environment), we determi...

  18. [Medical education: between science and Bildungsroman].

    Science.gov (United States)

    Marion-Veyron, Régis; Bourquin, Céline; Saraga, Michael; Stiefel, Friedrich

    2016-02-10

    For many years, a major focus of interest has been the patient, in the context of a constantly changing society and increasingly complex medical practices. We propose to shift this focus on the physician, who is entangled in a similar, but less evident way. In these three articles, we explore, in succession, the lived experience of the contemporary physician, the ethos which brings together the medical community, and the education of the future physician, using research projects currently under way within the Service of Liaison Psychiatry at Lausanne University Hospital. The article hereunder is dedicated to the education and will examine the multiple and paradoxical expectations that punctuate it. PMID:27039441

  19. [Medical education: between science and Bildungsroman].

    Science.gov (United States)

    Marion-Veyron, Régis; Bourquin, Céline; Saraga, Michael; Stiefel, Friedrich

    2016-02-10

    For many years, a major focus of interest has been the patient, in the context of a constantly changing society and increasingly complex medical practices. We propose to shift this focus on the physician, who is entangled in a similar, but less evident way. In these three articles, we explore, in succession, the lived experience of the contemporary physician, the ethos which brings together the medical community, and the education of the future physician, using research projects currently under way within the Service of Liaison Psychiatry at Lausanne University Hospital. The article hereunder is dedicated to the education and will examine the multiple and paradoxical expectations that punctuate it.

  20. Modern medical research ethics - bioethics

    Directory of Open Access Journals (Sweden)

    Vásquez Abanto J. E.

    2015-01-01

    Full Text Available For today, the medical association came to common opinion, that a doctor-scientist cannot be higher than the universal values. At a decision-making, equally with the scientific interests, which, undoubtedly, will bring to development of the theoretical and practical medicine, a doctor must take into account moral values. The doctrine of the informed consent of patient that is examined as a necessary condition of any medical interference became ethic basis of experiment with participation of human. An observance of confidentiality of the results of the studies is also very important. The present development of the biomedical knowledge supposes realization of human research in a good cause, after the conducted tests on the animals and the other models. A clinical test on human must take place only then, when the risk does not exceed the benefit. Carrying out of the biomedical studies is considered as illegal, unconscionable, amoral and even criminal action. If the regulations and the norms of the law are not observed, it entails penal offence. This article provides the basic foundations of medical activities rather moral standards of medical and research activity, which in the different periods underwent the changes dictated by moral requirements of an era and society are analyzed.

  1. Selective hair therapy: bringing science to the fiction.

    Science.gov (United States)

    Vogt, Annika; Blume-Peytavi, Ulrike

    2014-02-01

    Investigations on carrier-based drug delivery systems for higher selectivity in hair therapy have clearly evolved from dye release and model studies to highly sophisticated approaches, many of which specifically tackle hair indications and the delivery of hair-relevant molecules. Here, we group recent hair disease-oriented work into efforts towards (i) improved delivery of conventional drugs, (ii) delivery of novel drug classes, for example biomolecules and (iii) targeted delivery on the cellular/molecular level. Considering the solid foundation of experimental work, it does not take a large step outside the current box of thinking to follow the idea of using large carriers (>500 nm, unlikely to penetrate as a whole) for follicular penetration, retention and protection of sensitive compounds. Yet, reports on particles hair follicles) combined with recent advances in nanodermatology add interesting new facets to the possibilities carrier technologies could offer, for example, unprecedented levels of selectivity. The authors provide thought-provoking ideas on how smart delivery technologies and advances in our molecular understanding of hair pathophysiology could result in a whole new era of hair therapeutics. As the field still largely remains in preclinical investigation, determined efforts towards production of medical grade material and truly translational work are needed to demonstrate surplus value of carrier systems for clinical applications.

  2. Medical imaging.

    OpenAIRE

    Kreel, L.

    1991-01-01

    There is now a wide choice of medical imaging to show both focal and diffuse pathologies in various organs. Conventional radiology with plain films, fluoroscopy and contrast medium have many advantages, being readily available with low-cost apparatus and a familiarity that almost leads to contempt. The use of plain films in chest disease and in trauma does not need emphasizing, yet there are still too many occasions when the answer obtainable from a plain radiograph has not been available. Th...

  3. Medical Department

    International Nuclear Information System (INIS)

    Within Brookhaven National Laboratory, the life sciences program is carried out under two departments, the Medical Department and the Biological Department. The Medical Research Center contains three major divisions: the Hospital, the Research Laboratories, and the Occupational Medicine Clinic. The hospital, which is devoted entirely to research patients, supports clinical studies in: pulmonary diseases; neuropsychiatric disorders; hematological diseases (e.g., chronic lymphocytic leukemia); cardiopulmonary disorders; hepatobiliary dysfunction; cancer of various types; toxicological problems; bone and mineral metabolism; and dietary and nutritional disorders. Research efforts are also made to improve therapeutic measures for disease: brain tumor therapy through boron capture of epithermal neutrons, and proton beam irradiation; extracorporeal irradiation of blood in leukemia; iron chelator efficacy in thalassemia; and nonsurgical treatment of ocular melanoma. Early diagnoses and studies of the mechanism of disease are approached through medical applications of nuclear technology, including positron emission tomography. Work carried out within the Biological Department includes: biological structure determination, molecular genetics, DNA repair and plant sciences. A large part of the research is devoted to understanding how biological systems work. Central to this aim is the study of DNA. This includes effects of damage by physical and chemical agents, gene cloning of bacteria and plants and effects of low doses of radiation and other energy derived hazards

  4. Medical Applications

    Science.gov (United States)

    Boccara, A. Claude; Mordon, Serge

    2015-10-01

    In re-listening to the lectures of Charles Townes shortly after the invention of the laser (e.g., in the Boston Science Museum), one can already have a realistic vision of the potentialities of this new tool in the field of medical therapy, as evidenced by the use of the laser in ophthalmology to cure retinal detachment in the 1960's. Since then, applications have flourished in the domain of therapy. We will thus illustrate here only some of the main fields of application of medical lasers. On the opposite, the use of lasers in medical imaging is, with one exception in ophthalmology, still at the development level. It is becoming a diagnostic tool in addition to high performance imaging facilities that are often very expensive (such as CT scan, Magnetic Resonance Imaging (MRI) and nuclear imaging). Even if progress is sometimes slow, one can now image with light inside the human body, in spite of the strong scattering of light by tissues, in the same way as a pathologist sees surgical specimens.

  5. The medical record system in acute situations at Okhaldhunga Community Hospital

    OpenAIRE

    Thaulow, Eli Øyen

    2014-01-01

    Background: Okhaldhunga community hospital lies in rural Nepal, and is a hospital with simple equipment and facilities. The supply of power is little, therefore it does not excist any electronical medical record system. Each patient has its own notebook, which serves as their medical record, and each patient is responsible for this medical record. That means that they bring their medical record back home when they are discharged from the hospital, and the hospital has no archive. Two other no...

  6. Tools for GPCR drug discovery

    Institute of Scientific and Technical Information of China (English)

    Ru ZHANG; Xin XIE

    2012-01-01

    G-protein-coupled receptors (GPCRs) mediate many important physiological functions and are considered as one of the most successful therapeutic targets for a broad spectrum of diseases.The design and implementation of high-throughput GPCR assays that allow the cost-effective screening of large compound libraries to identify novel drug candidates are critical in early drug discovery.Early functional GPCR assays depend primarily on the measurement of G-protein-mediated 2nd messenger generation.Taking advantage of the continuously deepening understanding of GPCR signal transduction,many G-protein-independent pathways are utilized to detect the activity of GPCRs,and may provide additional information on functional selectivity of candidate compounds.With the combination of automated imaging systems and label-free detection systems,such assays are now suitable for high-throughput screening (HTS).In this review,we summarize the most widely used GPCR assays and recent advances in HTS technologies for GPCR drug discovery.

  7. Knowledge discovery by accuracy maximization.

    Science.gov (United States)

    Cacciatore, Stefano; Luchinat, Claudio; Tenori, Leonardo

    2014-04-01

    Here we describe KODAMA (knowledge discovery by accuracy maximization), an unsupervised and semisupervised learning algorithm that performs feature extraction from noisy and high-dimensional data. Unlike other data mining methods, the peculiarity of KODAMA is that it is driven by an integrated procedure of cross-validation of the results. The discovery of a local manifold's topology is led by a classifier through a Monte Carlo procedure of maximization of cross-validated predictive accuracy. Briefly, our approach differs from previous methods in that it has an integrated procedure of validation of the results. In this way, the method ensures the highest robustness of the obtained solution. This robustness is demonstrated on experimental datasets of gene expression and metabolomics, where KODAMA compares favorably with other existing feature extraction methods. KODAMA is then applied to an astronomical dataset, revealing unexpected features. Interesting and not easily predictable features are also found in the analysis of the State of the Union speeches by American presidents: KODAMA reveals an abrupt linguistic transition sharply separating all post-Reagan from all pre-Reagan speeches. The transition occurs during Reagan's presidency and not from its beginning.

  8. Discovery of a Makemakean Moon

    CERN Document Server

    Parker, Alex H; Grundy, Will M; Noll, Keith S

    2016-01-01

    We describe the discovery of a satellite in orbit about the dwarf planet (136472) Makemake. This satellite, provisionally designated S/2015 (136472) 1, was detected in imaging data collected with the Hubble Space Telescope's Wide Field Camera 3 on UTC April 27, 2015 at 7.80$\\pm$0.04 magnitudes fainter than Makemake. It likely evaded detection in previous satellite searches due to a nearly edge-on orbital configuration, placing it deep within the glare of Makemake during a substantial fraction of its orbital period. This configuration would place Makemake and its satellite near a mutual event season. Insufficient orbital motion was detected to make a detailed characterization of its orbital properties, prohibiting a measurement of the system mass with the discovery data alone. Preliminary analysis indicates that if the orbit is circular, its orbital period must be longer than 12.4 days, and must have a semi-major axis $\\gtrsim$21,000 km. We find that the properties of Makemake's moon suggest that the majority ...

  9. The Medical Council of India and its revolutionary, way of allowing Indian medical graduates from foreign universities to practice in India.

    Science.gov (United States)

    Raju, C

    2005-08-01

    This paper attempts to sensitize the participants to understand the benefits of looking at the regulations of accreditation for medical courses in the neighbouring nearby countries. Deregulation of Medical Education like what they have done will bring enormous revenue benefits for the existing assets like the airports, hospitals, hotels resorts and the communication infrastructure of Malaysia.

  10. Price Discovery in the Chinese Gold Market

    OpenAIRE

    Jin, Muzhao; Li, Youwei; Wang, Jianxin; Yang, Yung Chiang

    2016-01-01

    This study conducts price discovery analysis in the Chinese gold market. Our result indicates that the price discovery in Chinese gold market occurs predominantly in the futures market. The result is robust to the different measures of price discovery, namely information share, component share, and information leadership share. Partitioning the daily trades into three trading sessions, we find that the dominance of the futures market occurs in all trading sessions. We further investigate the ...

  11. MODIS: an audio motif discovery software

    OpenAIRE

    Catanese, Laurence; Souviraà-Labastie, Nathan; Qu, Bingqing; Campion, Sébastien; Gravier, Guillaume; Vincent, Emmanuel; Bimbot, Frédéric

    2013-01-01

    International audience MODIS is a free speech and audio motif discovery software developed at IRISA Rennes. Motif discovery is the task of discovering and collecting occurrences of repeating patterns in the absence of prior knowledge, or training material. MODIS is based on a generic approach to mine repeating audio sequences, with tolerance to motif variability. The algorithm implementation allows to process large audio streams at a reasonable speed where motif discovery often requires hu...

  12. 20 CFR 1002.308 - Who has legal standing to bring an action under USERRA?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Who has legal standing to bring an action under USERRA? 1002.308 Section 1002.308 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR... Rights and Benefits Against A State Or Private Employer § 1002.308 Who has legal standing to bring...

  13. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Employees in retailing whose activities may bring them under the Act. 779.110 Section 779.110 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... Production of Goods for Commerce § 779.110 Employees in retailing whose activities may bring them under...

  14. Proteomics and Its Application in Biomarker Discovery and Drug Development

    Institute of Scientific and Technical Information of China (English)

    He Qing-Yu; Chiu Jen-Fu

    2004-01-01

    Proteomics is a research field aiming to characterize molecular and cellular dynamics in protein expression and function on a global level. The introduction of proteomics has been greatly broadening our view and accelerating our path in various medical researches. The most significant advantage of proteomics is its ability to examine a whole proteome or sub-proteome in a single experiment so that the protein alterations corresponding to a pathological or biochemical condition at a given time can be considered in an integrated way. Proteomic technology has been extensively used to tackle a wide variety of medical subjects including biomarker discovery and drug development. By complement with other new technique advance in genomics and bioinformatics,proteomics has a great potential to make considerable contribution to biomarker identification and revolutionize drug development process. A brief overview of the proteomic technologies will be provided and the application of proteomics in biomarker discovery and drug development will be discussed using our current research projects as examples.

  15. World-Wide Effort Bringing ALMA Telescope Into Reality

    Science.gov (United States)

    2008-02-01

    in detail about the complex chemistry of the giant clouds of gas and dust that spawn stars and planetary systems. Many other astronomical specialties also will benefit from the new capabilities of ALMA, In addition, "We know that every time in the past that a new wavelength region has been opened up, as ALMA will do, we have been surprised by entirely unexpected discoveries that significantly changed our understanding of the Universe. We also expect the unexpected from ALMA," Sargent said. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

  16. Medical electromechatronics

    Science.gov (United States)

    Osipov, Y. M.; Syryamkin, V. I.; Osipov, O. Y.

    2015-11-01

    The first part of the article presentsdevices of rehabilitation electromechatronics.As a research work, the author's team has performed sketch and technical developments on this subject, which are protected by patents of the Russian Federation. The second part providesan overview of medical robotic surgery, which is ideal for imperfections removing.It also describes capabilities of the author's team in development of active driveline based "iron" hands.Scalpels never tremble in the iron hands, which are not afraid of the aftershocks and never get tired.They can perform operations during not less than 48 consecutive hours.

  17. Medical robotics

    CERN Document Server

    Troccaz, Jocelyne

    2013-01-01

    In this book, we present medical robotics, its evolution over the last 30 years in terms of architecture, design and control, and the main scientific and clinical contributions to the field. For more than two decades, robots have been part of hospitals and have progressively become a common tool for the clinician. Because this domain has now reached a certain level of maturity it seems important and useful to provide a state of the scientific, technological and clinical achievements and still open issues. This book describes the short history of the domain, its specificity and constraints, and

  18. Medical Malpractice

    DEFF Research Database (Denmark)

    Grembi, Veronica

    2014-01-01

    MM first came to the attention of policy makers primarily in the USA where, from the 1970s, healthcare providers denounced problems in getting insurance for medical liability, pointing out to a crisis in the MM insurance market (Sage WM (2003) Understanding the first malpractice crisis of the 21th....../or its affordability, the withdrawal from the MM insurance of commercial insurers, the growth of MM public insurance or self-insurance solutions, the choice of no-fault rather than negligence liability, the adoption of enterprise liability for hospitals, the concerns for defensive medicine...

  19. [Medical nanodevices].

    Science.gov (United States)

    Sugimachi, Masaru; Sunagawa, Kenji

    2006-02-01

    Development of implantable medical nanodevices enables us continuous automatic treatment of patients from inside of their body. Bionic devices, interfacing with neural systems and substituting native functions, such as bionic pacemaker, bionic pressure controller are candidates to miniaturize. For such miniaturization, efforts to reduce size of power supply (e.g., biological fuel cell) and to establish reliable high-throughput, low power telecommunication (e.g., spread spectrum telecommunication) are required. Simple devices such as pacemakers would benefit from miniaturization by lowering invasion and by developing a new usage such as ventricular resynchronization. PMID:16454192

  20. Smoking cessation medications

    Science.gov (United States)

    Smoking cessation - medications; Smokeless tobacco - medications; Medications for stopping tobacco ... Creating a plan to help you deal with smoking urges. Getting support from a doctor, counselor, or ...

  1. Triplex DNA: Importance and its medical application

    OpenAIRE

    Noori Dalooei M; Mojoodi A

    1998-01-01

    Back in 1957, when investigators produced a triple-stranded form of DNA while studying synthetic nucleic acids, few researchers paid much attention to the discovery. However, triplex DNA was never entirely forgotton and especially since 1987 its structural and functional importance in biological systems as well as its medical applications and therapeutic potentional have been extensively studied. It was suggested that in triplex DNA, the third strand was hydrogen bonded and positioned in the ...

  2. Automating Spreadsheet Discovery & Risk Assessment

    CERN Document Server

    Perry, Eric

    2008-01-01

    There have been many articles and mishaps published about the risks of uncontrolled spreadsheets in today's business environment, including non-compliance, operational risk, errors, and fraud all leading to significant loss events. Spreadsheets fall into the realm of end user developed applications and are often absent the proper safeguards and controls an IT organization would enforce for enterprise applications. There is also an overall lack of software programming discipline enforced in how spreadsheets are developed. However, before an organization can apply proper controls and discipline to critical spreadsheets, an accurate and living inventory of spreadsheets across the enterprise must be created, and all critical spreadsheets must be identified. As such, this paper proposes an automated approach to the initial stages of the spreadsheet management lifecycle - discovery, inventory and risk assessment. Without the use of technology, these phases are often treated as a one-off project. By leveraging techn...

  3. Drug discovery from marine microbes.

    Science.gov (United States)

    Gerwick, William H; Fenner, Amanda M

    2013-05-01

    The marine environment has been a source of more than 20,000 inspirational natural products discovered over the past 50 years. From these efforts, 9 approved drugs and 12 current clinical trial agents have been discovered, either as natural products or as molecules inspired from the natural product structure. To a significant degree, these have come from collections of marine invertebrates largely obtained from shallow-water tropical ecosystems. However, there is a growing recognition that marine invertebrates are oftentimes populated with enormous quantities of "associated" or symbiotic microorganisms and that microorganisms are the true metabolic sources of these most valuable of marine natural products. Also, because of the inherently multidisciplinary nature of this field, a high degree of innovation is characteristic of marine natural product drug discovery efforts.

  4. Bring global issues to medical teaching%医学教育的全球化议题

    Institute of Scientific and Technical Information of China (English)

    Catherine Bateman; Tim Baker; Elske Hoornenborg; Ulrika Ericsson; 徐白羽; 吴朝霞

    2002-01-01

    全球化的不断深入,使得我们所有人都认识到我们已不能与国际议题分离开来。在“9·11”恐怖事件袭击美国后,我们中的许多人才感觉到全球化的真正含义是如此强烈地震撼了我们各自的国家。这个世界的相互联系,以及这种相互联系所带来的影响一下子变得非常真实。卫生领域也受到不断变化的国际化进程的深刻影响。从大范围流行的HIV/艾滋病所带来的恐惧到不断增加的移民、难民潮;从对国际制药专利制度的争论到世贸组织对卫生健康领域所产生的影响;当今的一切都影响着医务人员的工作。各自国家关起门来进行自己的医学教育的做法已显不够,新时代的医生想要并且需要更多的东西。

  5. [Clinical cases and historical-medical didactics].

    Science.gov (United States)

    Berti, Giuseppina Bock

    2004-01-01

    The discovery of remarkable documents dating back to the thirties and coming from the Policlinico Surgical Clinic of Milan, offers the possibility to be read in a historical clue too and to compare the constant discordances with the clinical contemporary practice. The aim is to point out the relationship between yesterday knowledges and critical today interpretations. The analysis can be suggested because certainly instructive and formative, also within the historical-medical didactics students of the courses of degree in Medicine and Nursing since the first match with the Medical Faculty.

  6. Trends in medical information retrieval on Internet.

    Science.gov (United States)

    Baujard, O; Baujard, V; Aurel, S; Boyer, C; Appel, R D

    1998-09-01

    Information on the World Wide Web is unstructured, distributed, multimedia and multilingual. Many tools have been developed to help users search for useful information: subject hierarchies, general search engines, browsers and search assistants. Although helpful, they present serious limitations, mainly in terms of precision, multilingual indexing and distribution. In this paper, we cover some on-line solutions to medical information discovery and present our own approach, the MARVIN (multi-agent retrieval vagabond on information network) project, which tackles medical information research with specialized cooperative retrieval agents. We also draw some outlines for future extensions. PMID:9861514

  7. A UDDI Search Engine for SVG Federated Medical Imaging Web Services

    OpenAIRE

    Sabah Mohammed; Jinan Fiaidhi; Marshal Hahn

    2006-01-01

    With more and more medical web services appearing on the web, web services discovery mechanism becomes essential. UDDI is an online registry standard to facilitate the discovery of business partners and services. However, most medical imaging applications exist within their own protected domain and were never designed to participate and operate with other applications across the web. However, private UDDI registries in federated organizations should be able to share the service descriptions a...

  8. Virtual Visit to the ATLAS Control Room by Open Discovery Space webinar in Europe

    CERN Document Server

    2013-01-01

    Open Discovery Space (ODS) is a socially-powered and multilingual open learning infrastructure to boost the adoption of eLearning resources. ODS brings millions of educational resources directly into school classrooms. A key part of planning engaging lessons is access to high-quality, trustworthy teaching content. The platform empowers teachers by helping them build their schools` digital libraries, join lively communities of peers to share best practices, and connect their schools virtually with the world`s best research centres, museums and libraries.

  9. Gravity's ghost and big dog scientific discovery and social analysis in the twenty-first century

    CERN Document Server

    Collins, Harry

    2013-01-01

    Gravity's Ghost and Big Dog brings to life science's efforts to detect cosmic gravitational waves. These ripples in space-time are predicted by general relativity, and their discovery will not only demonstrate the truth of Einstein's theories but also transform astronomy. Although no gravitational wave has ever been directly detected, the previous five years have been an especially exciting period in the field. Here sociologist Harry Collins offers readers an unprecedented view of gravitational wave research and explains what it means for an analyst to do work of this kind.

  10. A Tale of Two Discoveries: Comparing the Usability of Summon and EBSCO Discovery Service

    Science.gov (United States)

    Foster, Anita K.; MacDonald, Jean B.

    2013-01-01

    Web-scale discovery systems are gaining momentum among academic libraries as libraries seek a means to provide their users with a one-stop searching experience. Illinois State University's Milner Library found itself in the unique position of having access to two distinct discovery products, EBSCO Discovery Service and Serials Solutions' Summon.…

  11. GalenOWL: Ontology-based drug recommendations discovery

    Directory of Open Access Journals (Sweden)

    Doulaverakis Charalampos

    2012-12-01

    Full Text Available Abstract Background Identification of drug-drug and drug-diseases interactions can pose a difficult problem to cope with, as the increasingly large number of available drugs coupled with the ongoing research activities in the pharmaceutical domain, make the task of discovering relevant information difficult. Although international standards, such as the ICD-10 classification and the UNII registration, have been developed in order to enable efficient knowledge sharing, medical staff needs to be constantly updated in order to effectively discover drug interactions before prescription. The use of Semantic Web technologies has been proposed in earlier works, in order to tackle this problem. Results This work presents a semantic-enabled online service, named GalenOWL, capable of offering real time drug-drug and drug-diseases interaction discovery. For enabling this kind of service, medical information and terminology had to be translated to ontological terms and be appropriately coupled with medical knowledge of the field. International standards such as the aforementioned ICD-10 and UNII, provide the backbone of the common representation of medical data, while the medical knowledge of drug interactions is represented by a rule base which makes use of the aforementioned standards. Details of the system architecture are presented while also giving an outline of the difficulties that had to be overcome. A comparison of the developed ontology-based system with a similar system developed using a traditional business logic rule engine is performed, giving insights on the advantages and drawbacks of both implementations. Conclusions The use of Semantic Web technologies has been found to be a good match for developing drug recommendation systems. Ontologies can effectively encapsulate medical knowledge and rule-based reasoning can capture and encode the drug interactions knowledge.

  12. Medications (for IBS)

    Medline Plus

    Full Text Available ... Agents Antidiarrheal Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best ... Agents Antidiarrheal Agents Antidepressant Medications Newer IBS Medications ... Psychological Treatments Understanding Stress Cognitive Behavioral ...

  13. The Medical Home

    Science.gov (United States)

    ... Melon Smoothie Pregnant? Your Baby's Growth The Medical Home KidsHealth > For Parents > The Medical Home Print A ... for your child. What Does the Term "Medical Home" Mean? A medical home isn't a place ...

  14. Intraday Price Discovery in Fragmented Markets

    NARCIS (Netherlands)

    S.R. Ozturk (Sait); M. van der Wel (Michel); D.J.C. van Dijk (Dick)

    2014-01-01

    textabstractFor many assets, trading is fragmented across multiple exchanges. Price discovery measures summarize the informativeness of trading on each venue for discovering the asset’s true underlying value. We explore intraday variation in price discovery using a structural model with time-varying

  15. 2015 Update of the Discoveries of Isotopes

    CERN Document Server

    Thoennessen, M

    2016-01-01

    The 2015 update of the discovery of nuclide project is presented. Twenty new nuclides were observed for the first time in 2015. An overall review of all previous assignments was made in order to apply the discovery criteria consistently to all elements. In addition, a list of isotopes published so far only in conference proceedings or internal reports is included.

  16. Service discovery in heterogeneous wireless networks

    NARCIS (Netherlands)

    Blangé, M.J.; Karkowski, I.P.; Vermeulen, B.C.B.

    2005-01-01

    In this paper we describe a possible solution to the problem of service discovery in heterogeneous wireless networks. This solution involves introduction of a network independent service discovery layer, with as main goal the improved robustness of applications running on top of it. A possible imple

  17. Scaling Bayesian network discovery through incremental recovery

    NARCIS (Netherlands)

    Castelo, J.R.; Siebes, A.P.J.M.

    1999-01-01

    Bayesian networks are a type of graphical models that, e.g., allow one to analyze the interaction among the variables in a database. A well-known problem with the discovery of such models from a database is the ``problem of high-dimensionality''. That is, the discovery of a network from a database w

  18. DISCOVERY OF EVIDENCE IN INTERNATIONAL COMMERCIAL ARBITRATION

    Directory of Open Access Journals (Sweden)

    Bakumenko, V.V.

    2016-07-01

    Full Text Available The article considers the different concepts of discovery of evidence, which exist under different legal jurisdictions, with their theoretical analysis to determine the feasibility and rationality of the application of the discovery mechanisms in the frameworks of international commercial arbitration and its fundamental principles.

  19. In silico discoveries for biomedical sciences

    NARCIS (Netherlands)

    Haagen, Herman van

    2011-01-01

    Text-mining is a challenging field of research initially meant for reading large text collections with a computer. Text-mining is useful in summarizing text, searching for the informative documents, and most important to do knowledge discovery. Knowledge discovery is the main subject of this thesis.

  20. 49 CFR 1121.2 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... procedures set forth at 49 CFR part 1114, subpart B. Discovery may begin upon the filing of the petition for exemption or petition for revocation of an exemption. In petitions to revoke an exemption, a party must... requests at the same time it files its petition to revoke. Discovery shall be completed 30 days after...

  1. Effective Online Group Discovery in Trajectory Databases

    DEFF Research Database (Denmark)

    Li, Xiaohui; Ceikute, Vaida; Jensen, Christian S.;

    2013-01-01

    GPS-enabled devices are pervasive nowadays. Finding movement patterns in trajectory data stream is gaining in importance. We propose a group discovery framework that aims to efficiently support the online discovery of moving objects that travel together. The framework adopts a sampling...

  2. A Discovery Chemistry Experiment on Buffers

    Science.gov (United States)

    Kulevich, Suzanne E.; Herrick, Richard S.; Mills, Kenneth V.

    2014-01-01

    The Holy Cross Chemistry Department has designed and implemented an experiment on buffers as part of our Discovery Chemistry curriculum. The pedagogical philosophy of Discovery Chemistry is to make the laboratory the focal point of learning for students in their first two years of undergraduate instruction. We first pose questions in prelaboratory…

  3. Proteomics: a new approach for drug discovery

    Institute of Scientific and Technical Information of China (English)

    Xue-junLI; YangXIANG; Hui-kaiTIAN; BingMA; Xiao-haoYAO; Hong-meiZHANG; He-mingYU

    2004-01-01

    Proteomics is a bridge that crosses genome to drug discovery. Proteomic studies will provide possible targets for therapeutic usage and moreover increase the efficiency of the downstream of drug discovery process. By using the 2-D electrophoresis combining with MS technology, which is most preva-lent techniques of proteome, we have identified more than 20

  4. Discovery of inhibitors of bacterial histidine kinases

    NARCIS (Netherlands)

    Velikova, N.R.

    2014-01-01

    Discovery of Inhibitors of Bacterial Histidine Kinases

    Summary

    The thesis is on novel antibacterial drug discovery (http://youtu.be/NRMWOGgeysM). Using structure-based and fragment-based dru

  5. 49 CFR 1503.633 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... Rules of Practice in TSA Civil Penalty Actions § 1503.633 Discovery. (a) Initiation of discovery. Any..., TSA may provide SSI to the party when, in the sole discretion of TSA, access to the SSI is necessary for the party to prepare a response to allegations contained the complaint. TSA may provide...

  6. Accounting for discovery bias in genomic prediction

    Science.gov (United States)

    Our objective was to evaluate an approach to mitigating discovery bias in genomic prediction. Accuracy may be improved by placing greater emphasis on regions of the genome expected to be more influential on a trait. Methods emphasizing regions result in a phenomenon known as “discovery bias” if info...

  7. 12 CFR 1780.26 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... Constitution, any applicable act of Congress, or the principles of common law. (e) Time limits. All discovery... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Discovery. 1780.26 Section 1780.26 Banks and... OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Prehearing Proceedings § 1780.26...

  8. He who pays the piper: foundations, the medical profession, and medical education reform.

    Science.gov (United States)

    Brown, E R

    1980-01-01

    The development of modern medical education was shaped by the medical profession's own reform strategies and by material and ideological support from the corporate class. This article examines how the Rockefeller medical philanthropies, the largest single source of funds for medical education reform from 1910 through the 1930s, forced the adoption of a specific reform--full-time clinical faculty--to make medicine serve the needs of capitalist society rather than the interests of the medical profession. Memorandums and letters from archival files demonstrate that foundation leaders believed the full-time plan would separate medical schools from the grip of practitioner-dominated medical societies, bringing all medical faculty under the control of foundations and university boards of trustees. This policy was to be a first step in rationalizing medical care and distributing the technical benefits and social-control functions of medicine to all segments of the population. The author traces the development of the full-time plan, its adoption as foundation policy, and the struggle over its implementation.

  9. THE CALIFORNIA MEDICAL MALPRACTICE PICTURE.

    Science.gov (United States)

    RUBSAMEN, D S

    1963-11-01

    The California physician's steadily increasing risk of legal liability poses a basic question: Will he ultimately wind up a guarantor of results, carrying a great burden of malpractice insurance in order to pay for every untoward result of medical treatment? This alarming prospect is the result of many years of judicial (and therefore lay) speculation on the legal significance of the injury which brings the patient into court. Does it look as though this injury probably is associated with medical negligence? If so, let the doctor explain. And the explanation must be very complete. The legal instrument which thus reverses the traditional requirements of proof, permitting the patient-plaintiff to remain silent while the doctor-defendant must exculpate himself, is an evidentiary doctrine called res ipsa loquitur-the thing speaks for itself. The application of the doctrine relieves the patient-plaintiff of the necessity of producing an expert witness to point the finger and say, "The medical conduct that produced this injury was sub-standard." The increased use of the doctrine reflects a judicial conviction that in many parts of California physicians refuse to testify for the patient-plaintiff regardless of the merit to his case.A recent California Supreme Court decision suggests that the Court is not unaware of the adverse social consequences implicit in the irrational expansion of the physician's risk of legal liability. But a reversal of this trend would seem to be contingent on positive conduct from the medical profession in California-conduct demonstrating that no meritorious patient-plaintiff will fail in his malpractice lawsuit for lack of an expert medical witness. PMID:14081771

  10. [MEDICAL CANNABIS].

    Science.gov (United States)

    Naftali, Timna

    2016-02-01

    The cannabis plant has been known to humanity for centuries as a remedy for pain, diarrhea and inflammation. Current research is inspecting the use of cannabis for many diseases, including multiple sclerosis, epilepsy, dystonia, and chronic pain. In inflammatory conditions cannabinoids improve pain in rheumatoid arthritis and:pain and diarrhea in Crohn's disease. Despite their therapeutic potential, cannabinoids are not free of side effects including psychosis, anxiety, paranoia, dependence and abuse. Controlled clinical studies investigating the therapeutic potential of cannabis are few and small, whereas pressure for expanding cannabis use is increasing. Currently, as long as cannabis is classified as an illicit drug and until further controlled studies are performed, the use of medical cannabis should be limited to patients who failed conventional better established treatment.

  11. [MEDICAL CANNABIS].

    Science.gov (United States)

    Naftali, Timna

    2016-02-01

    The cannabis plant has been known to humanity for centuries as a remedy for pain, diarrhea and inflammation. Current research is inspecting the use of cannabis for many diseases, including multiple sclerosis, epilepsy, dystonia, and chronic pain. In inflammatory conditions cannabinoids improve pain in rheumatoid arthritis and:pain and diarrhea in Crohn's disease. Despite their therapeutic potential, cannabinoids are not free of side effects including psychosis, anxiety, paranoia, dependence and abuse. Controlled clinical studies investigating the therapeutic potential of cannabis are few and small, whereas pressure for expanding cannabis use is increasing. Currently, as long as cannabis is classified as an illicit drug and until further controlled studies are performed, the use of medical cannabis should be limited to patients who failed conventional better established treatment. PMID:27215115

  12. Sampling: Making Electronic Discovery More Cost Effective

    Directory of Open Access Journals (Sweden)

    Milton Luoma

    2011-06-01

    Full Text Available With the huge volumes of electronic data subject to discovery in virtually every instance of litigation, time and costs of conducting discovery have become exceedingly important when litigants plan their discovery strategies.  Rather than incurring the costs of having lawyers review every document produced in response to a discovery request in search of relevant evidence, a cost effective strategy for document review planning is to use statistical sampling of the database of documents to determine the likelihood of finding relevant evidence by reviewing additional documents.  This paper reviews and discusses how sampling can be used to make document review more cost effective by considering issues such as an appropriate sample size, how to develop a sampling strategy, and taking into account the potential value of the litigation in relation to the costs of additional discovery efforts. 

  13. Medical applications of virtual reality.

    Science.gov (United States)

    Satava, R M

    1995-06-01

    Medical applications for virtual reality (VR) are just beginning to emerge. These include VR surgical simulators, telepresence surgery, complex medical database visualization, and rehabilitation. These applications are mediated through the computer interface and as such are the embodiment of VR as an integral part of the paradigm shift in the field of medicine. The Green Telepresence Surgery System consists of two components, the surgical workstation and remote worksite. At the remote site there is a 3-D camera system and responsive manipulators with sensory input. At the workstation there is a 3-D monitor and dexterous handles with force feedback. The VR surgical simulator is a stylized recreation of the human abdomen with several essential organs. Using a helmet mounted display and DataGlove, a person can learn anatomy from a new perspective by 'flying' inside and around the organs, or can practice surgical procedures with a scalpel and clamps. Database visualization creates 3-D images of complex medical data for new perspectives in analysis. Rehabilitation medicine permits impaired individuals to explore worlds not otherwise available to them, allows accurate assessment and therapy for their disabilities, and helps architects understand their critical needs in public or personal space. And to support these advanced technologies, the operating room and hospital of the future will be first designed and tested in virtual reality, bringing together the full power of the digital physician.

  14. To Scan or not to Scan: Consideration of Medical Benefit in the Justification of CT Scanning.

    Science.gov (United States)

    McCollough, Cynthia H

    2016-03-01

    While there are ongoing debates with regard to the level of risk, if any, associated with medical imaging, the benefits from medical imaging exams are well documented. This forum article looks at outcome-based medical studies and guidance from expert panels in an effort to bring the benefits of medical imaging, specifically CT imaging, into focus. The position is taken that imaging, medical, and safety communities must not continue to discuss small hypothetical risks from ionizing radiation without emphasizing the large well-documented benefits from medical imaging exams that use ionizing radiation. PMID:26808885

  15. Assessment of composite motif discovery methods

    Directory of Open Access Journals (Sweden)

    Johansen Jostein

    2008-02-01

    Full Text Available Abstract Background Computational discovery of regulatory elements is an important area of bioinformatics research and more than a hundred motif discovery methods have been published. Traditionally, most of these methods have addressed the problem of single motif discovery – discovering binding motifs for individual transcription factors. In higher organisms, however, transcription factors usually act in combination with nearby bound factors to induce specific regulatory behaviours. Hence, recent focus has shifted from single motifs to the discovery of sets of motifs bound by multiple cooperating transcription factors, so called composite motifs or cis-regulatory modules. Given the large number and diversity of methods available, independent assessment of methods becomes important. Although there have been several benchmark studies of single motif discovery, no similar studies have previously been conducted concerning composite motif discovery. Results We have developed a benchmarking framework for composite motif discovery and used it to evaluate the performance of eight published module discovery tools. Benchmark datasets were constructed based on real genomic sequences containing experimentally verified regulatory modules, and the module discovery programs were asked to predict both the locations of these modules and to specify the single motifs involved. To aid the programs in their search, we provided position weight matrices corresponding to the binding motifs of the transcription factors involved. In addition, selections of decoy matrices were mixed with the genuine matrices on one dataset to test the response of programs to varying levels of noise. Conclusion Although some of the methods tested tended to score somewhat better than others overall, there were still large variations between individual datasets and no single method performed consistently better than the rest in all situations. The variation in performance on individual

  16. Swift: 10 Years of Discovery

    Science.gov (United States)

    The conference Swift: 10 years of discovery was held in Roma at La Sapienza University on Dec. 2-5 2014 to celebrate 10 years of Swift successes. Thanks to a large attendance and a lively program, it provided the opportunity to review recent advances of our knowledge of the high-energy transient Universe both from the observational and theoretical sides. When Swift was launched on November 20, 2004, its prime objective was to chase Gamma-Ray Bursts and deepen our knowledge of these cosmic explosions. And so it did, unveiling the secrets of long and short GRBs. However, its multi-wavelength instrumentation and fast scheduling capabilities made it the most versatile mission ever flown. Besides GRBs, Swift has observed, and contributed to our understanding of, an impressive variety of targets including AGNs, supernovae, pulsars, microquasars, novae, variable stars, comets, and much more. Swift is continuously discovering rare and surprising events distributed over a wide range of redshifts, out to the most distant transient objects in the Universe. Such a trove of discoveries has been addressed during the conference with sessions dedicated to each class of events. Indeed, the conference in Rome was a spectacular celebration of the Swift 10th anniversary. It included sessions on all types of transient and steady sources. Top scientists from around the world gave invited and contributed talks. There was a large poster session, sumptuous lunches, news interviews and a glorious banquet with officials attending from INAF and ASI. All the presentations, as well as several conference pictures, can be found in the conference website (http://www.brera.inaf.it/Swift10/Welcome.html). These proceedings have been collected owing to the efforts of Paolo D’Avanzo who has followed each paper from submission to final acceptance. Our warmest thanks to Paolo for all his work. The Conference has been made possible by the support from La Sapienza University as well as from the ARAP

  17. [Grmek, medical history, and paleopathology].

    Science.gov (United States)

    Thillaud, P L

    2001-01-01

    Mirko Drazen Grmek died on 6 March 2000, defeated by an implacable enemy (amyotrophic lateral sclerosis, which had been diagnosed just 18 months earlier). He has now found peace in his final resting place, the Montparnasse cemetery in Paris. His immense body of work reveals an omniscient man of great wisdom, a cosmopolitan polyglot who devoted his life to the history of science, with particular emphasis on medicine and disease. He looked at paleopathology for what that discipline could bring to the study of populations in antiquity, and succeeded in anchoring it in history with his definitive concept of "pathocenose", created in 1969. Several years later, his most important work, "Les Maladies à l'aube de la civilisation occidentale", (1983) set forth with definitive and convincing illustrations the importance of paleopathology, which will therefore be forever associated with one of the most outstanding medical history books of the XXth. century. PMID:11908523

  18. [Three aspects of the medical ethos].

    Science.gov (United States)

    Saraga, Michael; Marion-Veyron, Régis; Stiefel, Friedrich; Bourquin, Céline

    2016-02-10

    For many years, a major focus of interest has been the patient, in the context of a constantly changing society and increasingly complex medical practices. We propose to shift this focus on the physician, who is entangled in a similar, but less evident way. In these three articles, we explore, in succession, the lived experience of the contemporary physician, the ethos which brings together the medical community, and the education of the future physician, using research projects currently under way within the Service of Liaison Psychiatry at Lausanne University Hospital. Here, we describe three aspects of the medical ethos shaping medicine and the physicians: pragmatism, scientific rationality, and the individualistic embodiment of clinical practice. PMID:27039440

  19. Note from the CERN Medical Service

    CERN Multimedia

    Medical Service

    2004-01-01

    FLU VACCINATION People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2004. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  20. Note from the CERN Medical Service

    CERN Multimedia

    Medical Service

    2005-01-01

    FLU VACCINATION People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2006. CERN staff aged 50 or over are recommended to have the flu vaccination.  Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious illness or after major surgery . The Medical Service will not administer vaccines for family members or retired staff members, who must contact their usual family doctor. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  1. 3D in vitro technology for drug discovery.

    Science.gov (United States)

    Hosseinkhani, Hossein

    2012-02-01

    Three-dimensional (3D) in vitro systems that can mimic organ and tissue structure and function in vivo, will be of great benefit for a variety of biological applications from basic biology to toxicity testing and drug discovery. There have been several attempts to generate 3D tissue models but most of these models require costly equipment, and the most serious disadvantage in them is that they are too far from the mature human organs in vivo. Because of these problems, research and development in drug discovery, toxicity testing and biotech industries are highly expensive, and involve sacrifice of countless animals and it takes several years to bring a single drug/product to the market or to find the toxicity or otherwise of chemical entities. Our group has been actively working on several alternative models by merging biomaterials science, nanotechnology and biological principles to generate 3D in vitro living organs, to be called "Human Organs-on-Chip", to mimic natural organ/tissues, in order to reduce animal testing and clinical trials. We have fabricated a novel type of mechanically and biologically bio-mimicking collagen-based hydrogel that would provide for interconnected mini-wells in which 3D cell/organ culture of human samples in a manner similar to human organs with extracellular matrix (ECM) molecules would be possible. These products mimic the physical, chemical, and biological properties of natural organs and tissues at different scales. This paper will review the outcome of our several experiments so far in this direction and the future perspectives.

  2. Materials discovery through crystal growth

    Science.gov (United States)

    zur Loye, Hans-Conrad

    2016-04-01

    The discovery of new materials and associated desirable properties has been a driving force behind chemical innovation for centuries. When we look at some of the many recent technological advances, and how widespread and significant their impact has been, we appreciate how much they have relied on new materials. The increase in hard drive storage capacity due to new giant magneto-resistive materials, the ever-shrinking cell phone due to improved microwave dielectric materials, the enhancement in lithium battery storage capacity due to new intercalation materials, or the improved capacitor due to new ferroelectric materials are all excellent examples. How were these materials discovered? While there is no single answer, in all cases there was a First-Material, the archetype in which the phenomenon was first observed, the one that led to further investigations and the subsequent preparation of improved 2nd or 3rd generation materials. It is this First-Material, the archetype, that was discovered - often via crystal growth.

  3. Knowledge Discovery from Vibration Measurements

    Directory of Open Access Journals (Sweden)

    Jun Deng

    2014-01-01

    Full Text Available The framework as well as the particular algorithms of pattern recognition process is widely adopted in structural health monitoring (SHM. However, as a part of the overall process of knowledge discovery from data bases (KDD, the results of pattern recognition are only changes and patterns of changes of data features. In this paper, based on the similarity between KDD and SHM and considering the particularity of SHM problems, a four-step framework of SHM is proposed which extends the final goal of SHM from detecting damages to extracting knowledge to facilitate decision making. The purposes and proper methods of each step of this framework are discussed. To demonstrate the proposed SHM framework, a specific SHM method which is composed by the second order structural parameter identification, statistical control chart analysis, and system reliability analysis is then presented. To examine the performance of this SHM method, real sensor data measured from a lab size steel bridge model structure are used. The developed four-step framework of SHM has the potential to clarify the process of SHM to facilitate the further development of SHM techniques.

  4. The Discovery of Dabigatran Etexilate

    Directory of Open Access Journals (Sweden)

    Joanne evan Ryn

    2013-02-01

    Full Text Available Thromboembolic disease is a major cause of mortality and morbidity in the developed world and is caused by an excessive stimulation of coagulation. Thrombin is a key serine protease in the coagulation cascade and numerous efforts have been made to develop safe and effective orally active direct thrombin inhibitors (DTIs. Current anticoagulant therapy includes the use of indirect thrombin inhibitors (e.g. heparins, low-molecular-weight-heparins [LMWHs] and vitamin K antagonists (VKA such as warfarin. However there are several caveats in the clinical use of these agents including narrow therapeutic window, parenteral delivery, and food- and drug-drug interactions. Dabigatran is a synthetic, reversible DTI with high affinity and specificity for its target binding both free and clot-bound thrombin, and offers a favorable pharmacokinetic profile. Large randomized clinical trials have demonstrated that dabigatran provides comparable or superior thromboprophylaxis in multiple thromboembolic disease indications compared to standard of care. This minireview will highlight the discovery and development of dabigatran, the first in a class of new oral anticoagulant (NOAC agents to be licensed worldwide for the prevention of thromboembolism in the setting of orthopedic surgery and stroke prevent in atrial fibrillation.

  5. Discovery of Uniformly Expanding Universe

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2012-01-01

    Full Text Available Saul Perlmutter and the Brian Schmidt – Adam Riess teams reported that their Friedmann-model GR-based analysis of their supernovae magnitude-redshift data re- vealed a new phenomenon of “dark energy” which, it is claimed, forms 73% of the energy / matter density of the present-epoch universe, and which is linked to the further claim of an accelerating expansion of the universe. In 2011 Perlmutter, Schmidt and Riess received the Nobel Prize in Physics “for the discovery of the accelerating ex- pansion of the Universe through observations of distant supernovae”. Here it is shown that (i a generic model-independent analysis of this data reveals a uniformly expanding universe, (ii their analysis actually used Newtonian gravity, and finally (iii the data, as well as the CMB fluctuation data, does not require “dark energy” nor “dark matter”, but instead reveals the phenomenon of a dynamical space, which is absent from the Friedmann model.

  6. Knowledge discovery from vibration measurements.

    Science.gov (United States)

    Deng, Jun; Li, Jian; Wang, Daoyao

    2014-01-01

    The framework as well as the particular algorithms of pattern recognition process is widely adopted in structural health monitoring (SHM). However, as a part of the overall process of knowledge discovery from data bases (KDD), the results of pattern recognition are only changes and patterns of changes of data features. In this paper, based on the similarity between KDD and SHM and considering the particularity of SHM problems, a four-step framework of SHM is proposed which extends the final goal of SHM from detecting damages to extracting knowledge to facilitate decision making. The purposes and proper methods of each step of this framework are discussed. To demonstrate the proposed SHM framework, a specific SHM method which is composed by the second order structural parameter identification, statistical control chart analysis, and system reliability analysis is then presented. To examine the performance of this SHM method, real sensor data measured from a lab size steel bridge model structure are used. The developed four-step framework of SHM has the potential to clarify the process of SHM to facilitate the further development of SHM techniques.

  7. Genetic algorithms for route discovery.

    Science.gov (United States)

    Gelenbe, Erol; Liu, Peixiang; Lainé, Jeremy

    2006-12-01

    Packet routing in networks requires knowledge about available paths, which can be either acquired dynamically while the traffic is being forwarded, or statically (in advance) based on prior information of a network's topology. This paper describes an experimental investigation of path discovery using genetic algorithms (GAs). We start with the quality-of-service (QoS)-driven routing protocol called "cognitive packet network" (CPN), which uses smart packets (SPs) to dynamically select routes in a distributed autonomic manner based on a user's QoS requirements. We extend it by introducing a GA at the source routers, which modifies and filters the paths discovered by the CPN. The GA can combine the paths that were previously discovered to create new untested but valid source-to-destination paths, which are then selected on the basis of their "fitness." We present an implementation of this approach, where the GA runs in background mode so as not to overload the ingress routers. Measurements conducted on a network test bed indicate that when the background-traffic load of the network is light to medium, the GA can result in improved QoS. When the background-traffic load is high, it appears that the use of the GA may be detrimental to the QoS experienced by users as compared to CPN routing because the GA uses less timely state information in its decision making. PMID:17186801

  8. West Nile Virus Drug Discovery

    Directory of Open Access Journals (Sweden)

    Siew Pheng Lim

    2013-12-01

    Full Text Available The outbreak of West Nile virus (WNV in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery. A number of approaches have been used to search for inhibitors of WNV, including viral infection-based screening, enzyme-based screening, structure-based virtual screening, structure-based rationale design, and antibody-based therapy. These efforts have yielded inhibitors of viral or cellular factors that are critical for viral replication. For small molecule inhibitors, no promising preclinical candidate has been developed; most of the inhibitors could not even be advanced to the stage of hit-to-lead optimization due to their poor drug-like properties. However, several inhibitors developed for related members of the family Flaviviridae, such as dengue virus and hepatitis C virus, exhibited cross-inhibition of WNV, suggesting the possibility to re-purpose these antivirals for WNV treatment. Most promisingly, therapeutic antibodies have shown excellent efficacy in mouse model; one of such antibodies has been advanced into clinical trial. The knowledge accumulated during the past fifteen years has provided better rationale for the ongoing WNV and other flavivirus antiviral development.

  9. Genetic algorithms for route discovery.

    Science.gov (United States)

    Gelenbe, Erol; Liu, Peixiang; Lainé, Jeremy

    2006-12-01

    Packet routing in networks requires knowledge about available paths, which can be either acquired dynamically while the traffic is being forwarded, or statically (in advance) based on prior information of a network's topology. This paper describes an experimental investigation of path discovery using genetic algorithms (GAs). We start with the quality-of-service (QoS)-driven routing protocol called "cognitive packet network" (CPN), which uses smart packets (SPs) to dynamically select routes in a distributed autonomic manner based on a user's QoS requirements. We extend it by introducing a GA at the source routers, which modifies and filters the paths discovered by the CPN. The GA can combine the paths that were previously discovered to create new untested but valid source-to-destination paths, which are then selected on the basis of their "fitness." We present an implementation of this approach, where the GA runs in background mode so as not to overload the ingress routers. Measurements conducted on a network test bed indicate that when the background-traffic load of the network is light to medium, the GA can result in improved QoS. When the background-traffic load is high, it appears that the use of the GA may be detrimental to the QoS experienced by users as compared to CPN routing because the GA uses less timely state information in its decision making.

  10. Discovery Mondays: Zoom on materials

    CERN Multimedia

    2003-01-01

    Following the success of the first Discovery Monday, which had over 100 visitors, the series of evening events in Microcosm continues. On Monday 2nd June, discover the world of materials. Find out how CERN scientists examine, manufacture and study different materials, at different scales. Did you know for example that using electrons you can observe a hair at a scale equivalent to looking at a boat with the naked eye? Also, that using ultrasound, you can measure the thickness of an object that is completely inaccessible? Find out more about these techniques, and also the high-tech machining and soldering that is carried out in CERN's central workshop. Plus, see how engineers can detect tiny leaks through solder points - essential for maintaining the vacuum in the LHC. The evening is open to all, without reservation, suggested age 12 and above. Rendez-vous in Microcosm on Monday 2nd June From 19.30 - 21.00 Free entry For more information : http://www.cern.ch/microcosm Using a scanning microscope, the head o...

  11. Students Excited by Stellar Discovery

    Science.gov (United States)

    2011-02-01

    In the constellation of Ophiuchus, above the disk of our Milky Way Galaxy, there lurks a stellar corpse spinning 30 times per second -- an exotic star known as a radio pulsar. This object was unknown until it was discovered last week by three high school students. These students are part of the Pulsar Search Collaboratory (PSC) project, run by the National Radio Astronomy Observatory (NRAO) in Green Bank, WV, and West Virginia University (WVU). The pulsar, which may be a rare kind of neutron star called a recycled pulsar, was discovered independently by Virginia students Alexander Snider and Casey Thompson, on January 20, and a day later by Kentucky student Hannah Mabry. "Every day, I told myself, 'I have to find a pulsar. I better find a pulsar before this class ends,'" said Mabry. When she actually made the discovery, she could barely contain her excitement. "I started screaming and jumping up and down." Thompson was similarly expressive. "After three years of searching, I hadn't found a single thing," he said, "but when I did, I threw my hands up in the air and said, 'Yes!'." Snider said, "It actually feels really neat to be the first person to ever see something like that. It's an uplifting feeling." As part of the PSC, the students analyze real data from NRAO's Robert C. Byrd Green Bank Telescope (GBT) to find pulsars. The students' teachers -- Debra Edwards of Sherando High School, Leah Lorton of James River High School, and Jennifer Carter of Rowan County Senior High School -- all introduced the PSC in their classes, and interested students formed teams to continue the work. Even before the discovery, Mabry simply enjoyed the search. "It just feels like you're actually doing something," she said. "It's a good feeling." Once the pulsar candidate was reported to NRAO, Project Director Rachel Rosen took a look and agreed with the young scientists. A followup observing session was scheduled on the GBT. Snider and Mabry traveled to West Virginia to assist in the

  12. 16 CFR 1025.36 - Motions to compel discovery.

    Science.gov (United States)

    2010-01-01

    ... ADJUDICATIVE PROCEEDINGS Discovery, Compulsory Process § 1025.36 Motions to compel discovery. If a party fails... examination to the extent possible with respect to other areas of inquiry before moving to compel discovery....

  13. Medical muddle.

    Science.gov (United States)

    Gartrell, Nanette

    2014-01-01

    Nanette Gartrell, MD, is a psychiatrist and researcher whose investigations have documented the mental health and psychological well-being of lesbian, gay, bisexual, and transgender (LGBT) people over the past four decades. Nanette is the principal investigator of an ongoing longitudinal study of lesbian families in which the children were conceived by donor insemination. Now in its 27th year, this project has been cited internationally in the debates over equality in marriage, foster care, and adoption. Previously on the faculty at Harvard Medical School and the University of California, San Francisco, Nanette is currently a Visiting Distinguished Scholar at the Williams Institute, UCLA School of Law. In 2013, Nanette received the Association of Women Psychiatrists Presidential Commendation Award for "selfless and enduring vision, leadership, wisdom, and mentorship in the fields of women's mental health, ethics, and gender research." At the age of 63, Nanette experienced a 3 ½ month period of intractable, incapacitating dizziness for which there was never a clear diagnosis. PMID:24400630

  14. How do we identify and foster talent in medical schools?

    DEFF Research Database (Denmark)

    Christensen, Mette Krogh; Cristiancho, Sayra; Jensen, Rune Dall

    2016-01-01

    Background: Talent is highly regarded in high performance sports as a key feature for athletes to succeed. In medicine, talent is not a commonly held conversation, even though, medical students are usually identified as high achieving, internally motivated individuals. We suggest that bringing...... talent into the conversation of medical education research, will help us enrich how medical schools design selection processes. In this workshop we will bring awareness into the notion of talent from sports science research and invite discussion around how to embrace talent identification and development....... Finally, the workshop aim to extent participants’ repertoire of strategies in identifying and fostering talent at their institutions. Structure of Workshop: The latest research on talent identification and development will be presented and discussed. Participants will engage in an exercise including...

  15. Investigations into Library Web-Scale Discovery Services

    OpenAIRE

    Vaughan, Jason

    2008-01-01

    Web-scale discovery services for libraries provide deep discovery to a library’s local and licensed content, and represent an evolution, perhaps a revolution, for end user information discovery as pertains to library collections.  This article frames the topic of web-scale discovery, and begins by illuminating web-scale discovery from an academic library’s perspective – that is, the internal perspective seeking widespread staff participation in the discovery conversation.  This included the c...

  16. Service Discovery – A Survey and Comparison

    Directory of Open Access Journals (Sweden)

    Bendaoud Karim Talal

    2013-07-01

    Full Text Available With the increasing number of services in the internet, companies’ intranets, and home networks: servicediscovery becomes an integral part of modern networked system. This paper provides a comprehensivesurvey of major solutions for service discovery. We cover techniques and features used in existing systems.Although a few survey articles have been published on this object, our contribution focuses on comparingand analyzing surveyed solutions according eight prime criteria, which we have defined before. Thiscomparison will be helpful to determine limits of existing discovery protocols and identify future researchopportunities in service discovery.

  17. Drug Discovery in Academia- the third way?

    Science.gov (United States)

    Frearson, Julie; Wyatt, Paul

    2010-01-01

    As the pharmaceutical industry continues to re-strategise and focus on low-risk, relatively short term gains for the sake of survival, we need to re-invigorate the early stages of drug discovery and rebalance efforts towards novel modes of action therapeutics and neglected genetic and tropical diseases. Academic drug discovery is one model which offers the promise of new approaches and an alternative organisational culture for drug discovery as it attempts to apply academic innovation and thought processes to the challenge of discovering drugs to address real unmet need. PMID:20922062

  18. Open PHACTS: semantic interoperability for drug discovery.

    Science.gov (United States)

    Williams, Antony J; Harland, Lee; Groth, Paul; Pettifer, Stephen; Chichester, Christine; Willighagen, Egon L; Evelo, Chris T; Blomberg, Niklas; Ecker, Gerhard; Goble, Carole; Mons, Barend

    2012-11-01

    Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially. PMID:22683805

  19. Two Kinds of Discovery: An Ontological Account

    CERN Document Server

    Gilead, Amihud

    2014-01-01

    What can we discover? As the discussion in this paper is limited to ontological considerations, it does not deal with the discovery of new concepts. It raises the following question: What are the entities or existents that we can discover? There are two kinds of such entities: (1) actual entities, and (2) possible entities, which are pure possibilities. The paper explains why the first kind of discovery depends primarily on the second kind. The paper illustrates the discoveries of individual pure possibilities by presenting examples such as the Higgs particle, Dirac's positron, and Pauli-Fermi's neutrino.

  20. Medical missionaries to China and the reformation of anatomy.

    Science.gov (United States)

    Fu, Louis

    2016-05-01

    The earliest record of human anatomy in chapters of the Yellow Emperor's Inner Classic is likely to be based upon proper dissections. The first incident of human dissection for medical purpose documented in the History of Han Dynasty occurred in AD 13. During the Sung dynasty, a physician prepared illustrations of internal organs of executed criminals, published in 1113 as the Images of Truth Successive Chinese medical treatises have plagiarized but preserved the anatomical diagrams without improvements or modifications. China had to wait till the mid-19th century for Anglo-American Protestant medical missionaries to bring about a complete and permanent reformation of anatomical science. PMID:24833543

  1. Note from the CERN Medical Service FLU VACCINATION

    CERN Multimedia

    Sylvain Weisz

    2002-01-01

    People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2002. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  2. Note from the CERN Medical Service: FLU VACCINATION

    CERN Multimedia

    2001-01-01

    CERN Members of personnel who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 16th October and 30th November 2001. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  3. NOTE FROM THE CERN MEDICAL SERVICE - FLU VACCINATION

    CERN Multimedia

    2002-01-01

    People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  4. Note from the CERN Medical Service FLU VACCINATION

    CERN Multimedia

    2003-01-01

    People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2003. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  5. Note from the CERN Medical Service: FLU VACCINATION

    CERN Multimedia

    2003-01-01

    People working on the CERN site who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 1st October and 30th November 2003. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  6. Note from the CERN Medical Service FLU VACCINATION

    CERN Multimedia

    2001-01-01

    CERN Members of personnel who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 16th October and 30th November 2000. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  7. Note from the CERN Medical Service FLU VACCINATION

    CERN Multimedia

    2000-01-01

    CERN Members of personnel who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 16th October and 30th November 2000. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  8. Note from the CERN Medical Service. FLU VACCINATION

    CERN Multimedia

    2001-01-01

    CERN Members of personnel who wish to be vaccinated may go to the Medical Service (ground-floor, bldg. 57), without a prior appointment, but THEY MUST BRING THEIR VACCINE WITH THEM. Ideally, vaccination should take place between 16th October and 30th November 2000. CERN staff aged 50 or over are recommended to have influenza vaccinations. Vaccination is particularly important for those suffering from chronic lung, cardio-vascular or kidney problems, for diabetics and those convalescing from serious medical problems or after serious surgical operations. The Medical Service will not administer vaccines for family members or retired staff members, who must contact their normal family doctor.

  9. A new evaluation methodology for literature-based discovery systems.

    Science.gov (United States)

    Yetisgen-Yildiz, Meliha; Pratt, Wanda

    2009-08-01

    While medical researchers formulate new hypotheses to test, they need to identify connections to their work from other parts of the medical literature. However, the current volume of information has become a great barrier for this task. Recently, many literature-based discovery (LBD) systems have been developed to help researchers identify new knowledge that bridges gaps across distinct sections of the medical literature. Each LBD system uses different methods for mining the connections from text and ranking the identified connections, but none of the currently available LBD evaluation approaches can be used to compare the effectiveness of these methods. In this paper, we present an evaluation methodology for LBD systems that allows comparisons across different systems. We demonstrate the abilities of our evaluation methodology by using it to compare the performance of different correlation-mining and ranking approaches used by existing LBD systems. This evaluation methodology should help other researchers compare approaches, make informed algorithm choices, and ultimately help to improve the performance of LBD systems overall.

  10. Automated Knowledge Discovery From Simulators

    Science.gov (United States)

    Burl, Michael; DeCoste, Dennis; Mazzoni, Dominic; Scharenbroich, Lucas; Enke, Brian; Merline, William

    2007-01-01

    A computational method, SimLearn, has been devised to facilitate efficient knowledge discovery from simulators. Simulators are complex computer programs used in science and engineering to model diverse phenomena such as fluid flow, gravitational interactions, coupled mechanical systems, and nuclear, chemical, and biological processes. SimLearn uses active-learning techniques to efficiently address the "landscape characterization problem." In particular, SimLearn tries to determine which regions in "input space" lead to a given output from the simulator, where "input space" refers to an abstraction of all the variables going into the simulator, e.g., initial conditions, parameters, and interaction equations. Landscape characterization can be viewed as an attempt to invert the forward mapping of the simulator and recover the inputs that produce a particular output. Given that a single simulation run can take days or weeks to complete even on a large computing cluster, SimLearn attempts to reduce costs by reducing the number of simulations needed to effect discoveries. Unlike conventional data-mining methods that are applied to static predefined datasets, SimLearn involves an iterative process in which a most informative dataset is constructed dynamically by using the simulator as an oracle. On each iteration, the algorithm models the knowledge it has gained through previous simulation trials and then chooses which simulation trials to run next. Running these trials through the simulator produces new data in the form of input-output pairs. The overall process is embodied in an algorithm that combines support vector machines (SVMs) with active learning. SVMs use learning from examples (the examples are the input-output pairs generated by running the simulator) and a principle called maximum margin to derive predictors that generalize well to new inputs. In SimLearn, the SVM plays the role of modeling the knowledge that has been gained through previous simulation trials

  11. The discovery of Maxwell's equations

    Science.gov (United States)

    Everitt, Francis

    2012-02-01

    In January 1865, Maxwell at age 34 wrote a letter to his cousin Charles Cay describing various doings, including his work on the viscosity of gases and a visit from two of the world's leading oculists to inspect the eyes of his dog ``Spice''. He added, ``I have also a paper afloat, with an electromagnetic theory of light, which, till I am convinced to the contrary, I hold to be great guns.'' That paper ``A Dynamical Theory of the Electromagnetic Field'' was his fourth on the subject. It was followed in 1868 by another, and then in 1873 by his massive two volume Treatise on Electricity and Magnetism. Even so, by the time of his death in 1879 as he was beginning a radically revised edition of the Treatise, much remained to be done. We celebrate here the 150^th anniversary of Maxwell's first astonished realization in 1862 of the link between electromagnetism and light. So revolutionary was this that 15 or more years went by before Lorentz, Poynting, FitzGerald, and others came to address it, sometimes with improvements, sometimes not. Not until 1888 did Hertz make the essential experimental discovery of radio waves. What is so remarkable about Maxwell's five papers is that each presents a complete view of the subject radically different from the one before. I shall say something about each, emphasizing in particular Maxwell's most unexpected idea, the displacement current, so vastly more interesting than the accounts of it found in textbooks today. Beyond lie other surprises. The concept of gauge invariance, and the role the vector potential would play in defining the canonical momentum of the electron, both go back to Maxwell. In 1872 came a paper ``On the Mathematical Classification of Physical Quantities'', which stands as an education in itself. Amid much else, there for the first time appears the distinction between axial and polar vectors and those new operational concepts related to quaternion theory: curl, divergence, and gradient.

  12. Medical marketplace

    Science.gov (United States)

    Moretti, Michael

    1991-08-01

    Solid state lasers are the real highlight of my talk today, and were really the star of the year. In every application area I can think of, people have tried with some success to introduce corturiercial solid state products. I'll go into more detail, but aside from solid state, a very significant event happened in Deceniber when one of the laser angioplasty companies (Advanced Interventional Systens) received FDA clearance to begin marketing the excimer for coronary applications (Figure 1) . This is the first time to my knowledge that an excimer has ever been cleared for a medical application in the United States. It's an event that we didn't really expect to happen so soon. It's extremely significant and we'll see where it goes from here. The system needs to be road-tested a bit but to get past the FDA is the major obstacle. Looking back to solid state laser the importance of solid state lasers is as researchers become more involved with the excimer and conduct more clinical studies in ophthalmology, they realize that it's not going to be a panacea for all refractive surgery or other ophthalmolic applications. In many cases it looks like the solid state laser may be the laser of choice in certain types of surgery; most notably perhaps in refractive surgery. We've all read about the success of the excimer at least in capturing the press's attention for corneal sculpting and vision correction. Well, it could be that actually the next generation will be a solid state laser, so let's keep an open mind here.

  13. A cloud solution for medical image processing

    Directory of Open Access Journals (Sweden)

    Ali Mirarab,

    2014-07-01

    Full Text Available The rapid growth in the use of Electronic Health Records across the globe along with the rich mix of multimedia held within an EHR combined with the increasing level of detail due to advances in diagnostic medical imaging means increasing amounts of data can be stored for each patient. Also lack of image processing and analysis tools for handling the large image datasets has compromised researchers and practitioner‟s outcome. Migrating medical imaging applications and data to the Cloud can allow healthcare organizations to realize significant cost savings relating to hardware, software, buildings, power and staff, in addition to greater scalability, higher performance and resilience. This paper reviews medical image processing and its challenges, states cloud computing and cloud computing benefits due to medical image processing. Also, this paper introduces tools and methods for medical images processing using the cloud. Finally a method is provided for medical images processing based on Eucalyptus cloud infrastructure with image processing software “ImageJ” and using improved genetic algorithm for the allocation and distribution of resources. Based on conducted simulations and experimental results, the proposed method brings high scalability, simplicity, flexibility and fully customizability in addition to 40% cost reduction and twice increase in speed.

  14. [Medical publishing in Norway 1905-2005].

    Science.gov (United States)

    Nylenna, Magne; Larsen, Øivind

    2005-06-01

    The nation-building process in Norway took mainly place before the Norwegian-Swedish union came to a close in 1905. This was not a dramatic change, though the end of the union did bring a lift to Norwegian national consciousness. In 1905 there were three general medical journals in Norway and approximately 1200 doctors. German was the most important language of international science, but most scientific publishing was done in Norwegian. After the Second World War, English became the dominating language of scientific communication. Twentieth-century medicine and medical publishing was an era of specialisation and internationalisation. Norwegian medicine has to a large extent been internationalised through Nordic cooperation, with the Nordic specialist journals being of particular importance. With increasing professionalism in research, international English-language journals have become the major channels of communication, though several Norwegian-language journals (on paper or on the internet) have been established and are of crucial importance to a national identity within medical specialties. In 2005 there is only one general medical journal in Norwegian, in a country with approximately 20,000 doctors. A national identity related to medical publishing is not given much attention, though national medicine is still closely tied in with national culture. Good clinical practice should be based on a firm knowledge of local society and local tradition. This is a challenge in contemporary medical publishing.

  15. Association Rule Discovery and Its Applications

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Data mining, i.e. , mining knowledge from large amounts of data, is a demanding field since huge amounts of data have been collected in various applications. The collected data far exceed peoples ability to analyze it. Thus, some new and efficient methods are needed to discover knowledge from large database. Association rule discovery is an important problem in knowledge discovery and data mining.The association mining task consists of identifying the frequent item sets and then forming conditional implication rule among them. In this paper, we describe and summarize recent work on association rule discovery, offer a new method to association rule mining and point out that association rule discovery can be applied in spatial data mining. It is useful to discover knowledge from remote sensing and geographical information system.``

  16. Indexer Based Dynamic Web Services Discovery

    CERN Document Server

    Bashir, Saba; Javed, M Younus; Khan, Aihab; Khiyal, Malik Sikandar Hayat

    2010-01-01

    Recent advancement in web services plays an important role in business to business and business to consumer interaction. Discovery mechanism is not only used to find a suitable service but also provides collaboration between service providers and consumers by using standard protocols. A static web service discovery mechanism is not only time consuming but requires continuous human interaction. This paper proposed an efficient dynamic web services discovery mechanism that can locate relevant and updated web services from service registries and repositories with timestamp based on indexing value and categorization for faster and efficient discovery of service. The proposed prototype focuses on quality of service issues and introduces concept of local cache, categorization of services, indexing mechanism, CSP (Constraint Satisfaction Problem) solver, aging and usage of translator. Performance of proposed framework is evaluated by implementing the algorithm and correctness of our method is shown. The results of p...

  17. Specification Editing and Discovery Assistant Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The project will prototype a specification editing and discovery tool (SPEEDY) for C/C++ that will assist software developers with modular formal verification tasks...

  18. 6 CFR 13.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ...) In general. (1) The following types of discovery are authorized: (i) Requests for production of... Document or of the truth of any relevant fact; (iii) Written interrogatories; and (iv) Depositions....

  19. 34 CFR 33.21 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... types of discovery are authorized: (1) Requests for production of documents for inspection and copying. (2) Requests for admissions of the authenticity of any relevant document or of the truth of...

  20. 22 CFR 35.21 - Discovery.

    Science.gov (United States)

    2010-04-01

    ...) The following types of discovery are authorized: (1) Requests for production of documents for... truth of any relevant fact; (3) Written interrogatories; and (4) Depositions. (b) For the purpose...

  1. 45 CFR 79.21 - Discovery.

    Science.gov (United States)

    2010-10-01

    .... (a) The following types of discovery are authorized: (1) Requests for production of documents for... or of the truth of any revelant fact; (3) Written interrogatories; and (4) Depositions. (b) For...

  2. 12 CFR 308.520 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURE Program Fraud Civil Remedies and Procedures § 308.520 Discovery. (a) The following types of... for admission of the authenticity of any relevant document or of the truth of any relevant fact;...

  3. 10 CFR 1013.21 - Discovery.

    Science.gov (United States)

    2010-01-01

    ... following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests for admissions of the authenticity of any relevant document or of the truth of...

  4. Discovery announced of four new elements

    Science.gov (United States)

    Banks, Michael

    2016-02-01

    The International Union of Pure and Applied Chemistry (IUPAC) and the International Union of Pure and Applied Physics (IUPAP) have announced the discovery of four new elements: 113, 115, 117 and 118 - completing the periodic table's seventh row.

  5. DNA Coding Based Knowledge Discovery Algorithm

    Institute of Scientific and Technical Information of China (English)

    LI Ji-yun; GENG Zhao-feng; SHAO Shi-huang

    2002-01-01

    A novel DNA coding based knowledge discovery algorithm was proposed, an example which verified its validity was given. It is proved that this algorithm can discover new simplified rules from the original rule set efficiently.

  6. Priority of discovery in the life sciences.

    Science.gov (United States)

    Vale, Ronald D; Hyman, Anthony A

    2016-01-01

    The job of a scientist is to make a discovery and then communicate this new knowledge to others. For a scientist to be successful, he or she needs to be able to claim credit or priority for discoveries throughout their career. However, despite being fundamental to the reward system of science, the principles for establishing the "priority of discovery" are rarely discussed. Here we break down priority into two steps: disclosure, in which the discovery is released to the world-wide community; and validation, in which other scientists assess the accuracy, quality and importance of the work. Currently, in biology, disclosure and an initial validation are combined in a journal publication. Here, we discuss the advantages of separating these steps into disclosure via a preprint, and validation via a combination of peer review at a journal and additional evaluation by the wider scientific community. PMID:27310529

  7. Juvenile Arthritis: Discoveries Lead to Newer Treatments

    Science.gov (United States)

    ... For Consumers Home For Consumers Consumer Updates Juvenile Arthritis: Discoveries Lead to Newer Treatments Share Tweet Linkedin ... back to top Biologics: New Treatments for Juvenile Arthritis “As science at the molecular level has advanced, ...

  8. Anthelmintics – From Discovery to Resistance

    Directory of Open Access Journals (Sweden)

    Adrian J. Wolstenholme

    2014-12-01

    Full Text Available The scientific meeting entitled ‘Anthelmintics: From Discovery to Resistance’ was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites were covered in the oral and poster presentations. The attendees were from both academic and industrial backgrounds. In the present article we introduce a number of the papers that emerged from the meeting. Several of the papers covered current drug discovery efforts underway worldwide, with some specific examples focusing on ion channels, protein kinases and cysteine proteases. These efforts included the repurposing of known drugs as well as the discovery of novel actives. Two papers described recently-developed whole-organism screening techniques. Finally, we introduce several papers looking at mechanisms and management of drug resistance in human and veterinary parasites.

  9. Arthritis Genetics Analysis Aids Drug Discovery

    Science.gov (United States)

    ... Matters NIH Research Matters January 13, 2014 Arthritis Genetics Analysis Aids Drug Discovery An international research team ... may play a role in triggering the disease. Genetic factors are also thought to play a role. ...

  10. 29 CFR 1603.210 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.210 Discovery. (a) Unless otherwise ordered by...

  11. Combinatorial Discovery and Optimization of New Materials

    Institute of Scientific and Technical Information of China (English)

    Gao Chen; Zhang Xinyi; Yan Dongsheng

    2001-01-01

    The concept of the combinatorial discovery and optimization of new materials, and its background,importance, and application, as well as its current status in the world, are briefly reviewed in this paper.

  12. The National Cancer Program: Driving Discovery

    Science.gov (United States)

    An overview of NCI’s role in driving cancer research discoveries: conducting and funding research in challenging areas and providing resources and leadership to national infrastructures for cancer research.

  13. Xerostomy prevalence related to medication on patients assisted by the dentistry area of the UNIVILLE

    OpenAIRE

    Juliano Henrique PEROTTO; Kesly Mary Ribeiro ANDRADES; Aleysson Olimpio PAZA; Lúcia Ferreira de Castro ÁVILA

    2007-01-01

    The aim of this research was to know the xerostomy prevalence onpatients who have been assisted by the Dentistry Area of the Univilleand its relation with some drugs for the following treatments: arterial hypertension disease, seizure, depression and other diseases which require medication.The methodology consists of bringing aquestionnaire referent to patients’ health conditions, xerostomysymptoms and medications use. Patients were separated and analyzeddepending on the medication drug used ...

  14. The Medical Geology revolution——The evolution of an IUGS initiative

    Institute of Scientific and Technical Information of China (English)

    Olle Selinus; Robert B.Finkelman; Jose A.Centeno

    2007-01-01

    @@ Introduction In December 2003 Episodes published an article entitled"Medical Geology:New Relevance in the Earth Sciences"by Bowman,Bobrowski,and Selinus.This paper was iust one early example of the interest and excitement sparked by this emerging field of medical geology-the impacts of geologic materials and geologic processes on animal and human health.Medical geology attempts to bring together geoscientists and biomedical/public health researchers to address a range of environmental health problems.

  15. Acknowledging Stress in Undergraduate Medical Education and Methods of Overcoming it

    OpenAIRE

    Ujjwala Jayant kulkarni; M.S. Kate; Y.C. Shetty; Y.A. Deshmukh and V.V. Moghe

    2010-01-01

    Medical education is very demanding and stressful. Medical undergraduates face social, emotional and physical problems due to stress which affect their learning ability, academic performance and patient care. When students look at their education as a challenge, stress can bring them a sense of competence and increased capacity to learn but when education is seen as a threat, such stress can elicit feelings of helplessness. Each year of medical education is characterized having unique stress....

  16. Celebrating 20 years of the discovery of the top quark

    CERN Document Server

    Azzi, P

    2015-01-01

    An historical recount of the events leading to the discovery of the top quark in 1995 by the CDF and DO experiments at the Tevatron. 1 Introduction This presentation brings us back to the early nineties. It is interesting to picture ourselves without iphone and laptops, working on DEC VAX and having to stay in the office to work because there was no internet at home. The programming language was Fortran and plots were made with PAW. Detectors were becoming bigger and more complex, but no Silicon detector had been tried in a hadron collider yet. To put things in perspective for the LHC physicist of today: the MonteCarlo programs of the time did not differentiate between heavy and light quarks (VECBOS), there were no b-tagging algorithms, it was not clear that a Silicon detector could survive the radiation environement of an hadron collider such as the Tevatron and collecting data took a long time (one year for 20 pb-1). Nonetheless, working at the most powerful accelerator of the time was as exciting as it tod...

  17. [Use of GWAS for drug discovery and development].

    Science.gov (United States)

    Liou, Shyh-Yuh

    2014-01-01

    The Human Genome Project was completed in 2003. A catalog of common genetic variants in humans was built at the International HapMap Project. These variants, known as single nucleotide polymorphisms (SNPs), occur in human DNA and distributed among populations in different parts of the world. By using the Linkage Disequilibrium and mapping blocks are able to define quantitative characters of inherited diseases. Currently 50 K-5.0 M microarray are available commercially, which based on the results of following the ENCODE & 1000 genome projects. Therefore the genome wide association study (GWAS) has become a key tool for discovering variants that contribute to human diseases and provide maximum coverage of the genome, in contrast to the traditional approach in which only a few candidates genes was targeted. The available public GWAS databases provided valuable biological insights and new discovery for many common diseases, due to the availability of low cost microarray. The GWAS has the potential to provide a solution for the lack of new drug targets and reducing drug failure due to adverse drug reactions either. These are critical issues for pharmaceutical companies. Here, the Japan PGx Data Science Consortium (JPDSC), which was established on February 20, 2009 by six leading pharmaceutical companies in Japan, was introduced. We believe that the efforts of stakeholders including the regulatory authorities, health providers, and pharmaceutical companies to understand the potential and ethical risk of using genetic information including GWAS will bring benefits to patients in the future.

  18. Discovery of Two New Pulsars in 47 Tucanae (NGC 104)

    CERN Document Server

    Pan, Zhichen; Li, Di; Ridolfi, Alessandro; Wang, Pei; Freire, Paulo

    2016-01-01

    We report the discovery of two new millisecond pulsars (PSRs J0024$-$7204aa and J0024$-$7204ab) in the globular cluster 47\\,Tucanae (NGC 104). Our results bring the total number of pulsars in 47\\,Tucanae to 25. These pulsars were discovered by reprocessing archival observations from the Parkes radio telescope. We reprocessed the data using a standard search procedure based on the PRESTO software package as well as using a new method in which we incoherently added the power spectra corresponding to $\\sim$1100\\,hr of observations. The newly discovered PSR~J0024$-$7204aa, has a pulse frequency of $\\rm \\sim$541\\,Hz (corresponding to a $\\rm \\sim$1.84 ms period), which is higher than any other pulsars currently known in the cluster and ranks 12$^{\\rm{th}}$ amongst all the currently known pulsars. The dispersion measure of this pulsar, 24.941(7)\\,cm$^{-3}$ pc, is the highest in the cluster. The second discovered pulsar, PSR~J0024$-$7204ab, is an isolated pulsar with a pulse frequency of $\\rm \\sim$270\\,Hz (correspond...

  19. [Use of GWAS for drug discovery and development].

    Science.gov (United States)

    Liou, Shyh-Yuh

    2014-01-01

    The Human Genome Project was completed in 2003. A catalog of common genetic variants in humans was built at the International HapMap Project. These variants, known as single nucleotide polymorphisms (SNPs), occur in human DNA and distributed among populations in different parts of the world. By using the Linkage Disequilibrium and mapping blocks are able to define quantitative characters of inherited diseases. Currently 50 K-5.0 M microarray are available commercially, which based on the results of following the ENCODE & 1000 genome projects. Therefore the genome wide association study (GWAS) has become a key tool for discovering variants that contribute to human diseases and provide maximum coverage of the genome, in contrast to the traditional approach in which only a few candidates genes was targeted. The available public GWAS databases provided valuable biological insights and new discovery for many common diseases, due to the availability of low cost microarray. The GWAS has the potential to provide a solution for the lack of new drug targets and reducing drug failure due to adverse drug reactions either. These are critical issues for pharmaceutical companies. Here, the Japan PGx Data Science Consortium (JPDSC), which was established on February 20, 2009 by six leading pharmaceutical companies in Japan, was introduced. We believe that the efforts of stakeholders including the regulatory authorities, health providers, and pharmaceutical companies to understand the potential and ethical risk of using genetic information including GWAS will bring benefits to patients in the future. PMID:24694807

  20. The Pulsar Search Collaboratory: Three Years of Discovery

    Science.gov (United States)

    McLaughlin, Maura; Heatherly, S.; Rosen, R.

    2011-01-01

    The Pulsar Search Collaboratory (PSC) is a joint partnership between the National Radio Astronomy Observatory (NRAO) and West Virginia University (WVU) to improve the quality of science education in West Virginia high schools. The ultimate goal of the PSC is to engage students in science, technology, engineering, mathematics (STEM), and related fields by using information technology to conduct current scientific research, specifically searching for new pulsars. We expect to discover roughly 30 new pulsars in the PSC data. The PSC has had several scientific and educational successes. To date, the PSC students have made two astronomical discoveries: a 4.8-s pulsar and bright radio burst of astrophysical origin, most likely from a sporadic neutron star. We have 21 new high schools this year, bringing the number of PSC schools to 43. Ten of these schools are part of PSC West, a trial scale-up of our original PSC program. Of the 33 schools in the original PSC program, 13 come from rural school districts; one third of these are from schools where over 50% participate in the Free/Reduced School Lunch program. We are reaching first generation college-goers. For students, the program succeeds in building confidence in students, rapport with the scientists involved in the project, and team-work ability. We see additional gains in girls, who see themselves as scientists after participating in the PSC program. This is an important predictor of success in STEM fields.

  1. Television documentaries lifting hospital, medical center profiles.

    Science.gov (United States)

    Rees, T

    2001-01-01

    The nation's hospitals and medical centers are enjoying the legacy of TV audiences' addiction to medical dramas. Cable television has met the challenge with documentary coverage of real live hospitals. The medium offers many benefits and few disadvantages for those marketing managers with the courage to welcome camera crews. Lynn Hopkins Cantwell is director of public relations and marketing for Children's National Medical Center, Washington, D.C., which was covered in a seven-instrument "Lifeline" documentary for the Discovery Channel. James G. Gosky is director of communications for The MetroHealth System, Cleveland, which was the subject of two installments of "Trauma: Life in th ER," produced for the Learning Channel. These marketing pros describe the myriad details they faced when their respective hospitals went "on camera." Among the key factors were good communications with all constituents, attention to detail, and follow-up. PMID:11209289

  2. PTF SN discovery report, April 2012

    Science.gov (United States)

    Gal-Yam, Avishay; Arcavi, I.; Ben-Ami, S.; Yaron, O.; Nugent, P.; Levitam, D.; Simonian, G.; Sesar, B.; Cao, Y.; Horesh, A.; Bellm, E.; Silverman, J.; Miller, A.; Cenko, S. B.; Clubb, K. I.; Filippenko, A. V.; Shivvers, I.; Kasliwal, M.; Parrent, J.; Maguire, K.; Pan, Y.-C.

    2012-05-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf/; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 19 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  3. PTF SN discovery report, August 2012

    Science.gov (United States)

    Arcavi, Iair; Gal-Yam, A.; Ben-Ami, S.; Yaron, O.; Horesh, P. Nugent A.; Cao, Y.; Bellm, E.; Fynbo, J.; Wiis, J.; Olesen, J.; Engedal, L.; Larsen, A.; Kasliwal, M.; Pan, Y.-C.; Graham, M.; Parrent, J.; Quimby, R.; PTF Team

    2012-08-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 12 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  4. PTF SN discovery report, September 8, 2012

    Science.gov (United States)

    Gal-Yam, A.; Nugent, P.; Walker, E.; Cenko, S. B.; Fox, O.

    2012-09-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf ; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 8 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  5. PTF SN discovery report, July 2012

    Science.gov (United States)

    Gal-Yam, Avishay; Ben-Ami, Sagi; Arcavi, I.; Yaron, O.; Nugent, Peter; Sesar, B.; Cao, Y.; Silverman, J.; Clubb, K.; Filippenko, A. V.; Cenko, S. B.; Parrent, J.; Maguire, K.; Sullivan, M.

    2012-08-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf/ ; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 14 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  6. PTF SN discovery report, March 2012

    Science.gov (United States)

    Gal-Yam, Avishay; Arcavi, I.; Ben-Ami, S.; Yaron, O.; Nugent, P.; Levitam, D.; Simonian, G.; Sesar, B.; Cao, Y.; Horesh, A.; Bellm, E.; Silverman, J.; Miller, A.; Cenko, S. B.; Clubb, K. I.; Filippenko, A. V.; Shivvers, I.; Kasliwal, M.; Parrent, J.; Maguire, K.; Pan, Y.-C.

    2012-05-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf/; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 26 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  7. PTF SN discovery report, October 9, 2012

    Science.gov (United States)

    Gal-Yam, A.; Nugent, P.; Cao, Y.; Levitan, D.; Hallinan, G.; Kyne, G.; Silverman, J.; Clubb, K.; Miller, A.; Fox, O.; Suzuki, N.; Quimby, R.

    2012-10-01

    The PTF (ATEL #1964, #3253; http://www.astro.caltech.edu/ptf; Law et al. 2009, PASP, 121, 1395; Rau et al. 2009, PASP, 121, 1334) reports the discovery of 9 new supernovae. PTF discoveries are made by autonomous PTF software (Bloom et al. 2011, http://adsabs.harvard.edu/abs/2011arXiv1106.5491B ), as well as by the Galaxy Zoo Supernova Project (Smith et al. 2011, MNRAS, 412, 1309; http://supernova.galaxyzoo.org ).

  8. Toward discovery science of human brain function

    DEFF Research Database (Denmark)

    Biswal, Bharat B; Mennes, Maarten; Zuo, Xi-Nian;

    2010-01-01

    Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints...... in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/....

  9. Group Evolution Discovery in Social Networks

    OpenAIRE

    Bródka, Piotr; Saganowski, Stanisław; Kazienko, Przemysław

    2013-01-01

    Group extraction and their evolution are among the topics which arouse the greatest interest in the domain of social network analysis. However, while the grouping methods in social networks are developed very dynamically, the methods of group evolution discovery and analysis are still uncharted territory on the social network analysis map. Therefore the new method for the group evolution discovery called GED is proposed in this paper. Additionally, the results of the first experiments on the ...

  10. Impact of medical informatics on medical education.

    Science.gov (United States)

    Hou, S M

    1999-11-01

    In recent years, medical informatics has become a well-recognized branch of medicine. It is a multidisciplinary science that combines information technology and various specialties of medicine. The impact of medical informatics on medical education is advancing along with the rapid developments in computer science. Departments of medical informatics or similar divisions have appeared in schools of medicine in Taiwan in the past 5 years. At National Taiwan University College of Medicine, we offer curricula in basic computer concepts, network concepts, operating systems, word processing, database and data processing, computer media resources, multimedia computer statistics, intelligent health information systems, medical diagnostic support systems, and electronic medical record systems. Distance learning has also been favorably accepted on this campus. Recently, we proposed the concept of a virtual medical campus, which will break the physical barriers of time and space. We expect this revolution to influence every aspect of medicine, especially medical education. PMID:10705693

  11. Knowledge based cluster ensemble for cancer discovery from biomolecular data.

    Science.gov (United States)

    Yu, Zhiwen; Wongb, Hau-San; You, Jane; Yang, Qinmin; Liao, Hongying

    2011-06-01

    The adoption of microarray techniques in biological and medical research provides a new way for cancer diagnosis and treatment. In order to perform successful diagnosis and treatment of cancer, discovering and classifying cancer types correctly is essential. Class discovery is one of the most important tasks in cancer classification using biomolecular data. Most of the existing works adopt single clustering algorithms to perform class discovery from biomolecular data. However, single clustering algorithms have limitations, which include a lack of robustness, stability, and accuracy. In this paper, we propose a new cluster ensemble approach called knowledge based cluster ensemble (KCE) which incorporates the prior knowledge of the data sets into the cluster ensemble framework. Specifically, KCE represents the prior knowledge of a data set in the form of pairwise constraints. Then, the spectral clustering algorithm (SC) is adopted to generate a set of clustering solutions. Next, KCE transforms pairwise constraints into confidence factors for these clustering solutions. After that, a consensus matrix is constructed by considering all the clustering solutions and their corresponding confidence factors. The final clustering result is obtained by partitioning the consensus matrix. Comparison with single clustering algorithms and conventional cluster ensemble approaches, knowledge based cluster ensemble approaches are more robust, stable and accurate. The experiments on cancer data sets show that: 1) KCE works well on these data sets; 2) KCE not only outperforms most of the state-of-the-art single clustering algorithms, but also outperforms most of the state-of-the-art cluster ensemble approaches.

  12. Discovery Radiomics for Multi-Parametric MRI Prostate Cancer Detection

    CERN Document Server

    Chung, Audrey G; Kumar, Devinder; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

    2015-01-01

    Prostate cancer is the most diagnosed form of cancer in Canadian men, and is the third leading cause of cancer death. Despite these statistics, prognosis is relatively good with a sufficiently early diagnosis, making fast and reliable prostate cancer detection crucial. As imaging-based prostate cancer screening, such as magnetic resonance imaging (MRI), requires an experienced medical professional to extensively review the data and perform a diagnosis, radiomics-driven methods help streamline the process and has the potential to significantly improve diagnostic accuracy and efficiency, and thus improving patient survival rates. These radiomics-driven methods currently rely on hand-crafted sets of quantitative imaging-based features, which are selected manually and can limit their ability to fully characterize unique prostate cancer tumour phenotype. In this study, we propose a novel \\textit{discovery radiomics} framework for generating custom radiomic sequences tailored for prostate cancer detection. Discover...

  13. "ocean Discovery": At-Sea Research Opportunities for the Next Generation of Scientists

    Science.gov (United States)

    Hanisak, M.; Frank, T. M.

    2012-12-01

    The Cooperative Institute for Ocean Exploration, Research and Technology (CIOERT) explores and studies the nation's ocean frontiers using innovation and cutting edge technologies. CIOERT is committed to bringing "science at sea" experiences to university students, in the context of a complete research project-from data collection to presentation. Multidisciplinary :Ocean Discovery" cruises, designed to communicate the excitement of research and discovery to university students at a critical stage of their career decision-making have been incorporated into CIOERT's two Florida Shelf Edge Explorations , including use of the Johnson-Sea-Link II submersible (2010) and the University of Connecticut's K2 ROV (2011) CIOERT's "Ocean Discovery. "Ocean Discovery" provides a high-quality research experience for students by engagement in ocean research through shipboard data collections and analyses. Student research questions are created in association with CIOERT research projects and result in a written paper and poster presentation. Through active engagement in the entire process of research, students not only increase their understanding of the scientific process, but they will also observe, study, and characterize ocean conditions and selected benthic and pelagic habitats across the continental shelf. Student presentations impact their peers and younger students who may then also aspire to ocean-related careers. Student experiences and knowledge are transferred to the general public, college students, pre-college teachers, and their students via presentations and web-based resources. There is a high probability the Ocean Discovery students will become tomorrow's marine scientists, educators, and managers, all working, directly or indirectly, in support of NOAA's mission.;

  14. History of the Discovery of Mira Stars

    Science.gov (United States)

    Hoffleit, Dorrit

    This year we celebrate the 400th anniversary of Fabricius' discovery of Mira, "The Wonderful," in 1596. But was he the first? Within the first century following Fabricius, four Mira-type variables were discovered, and in all cases it has been found that the stars were suspected of being novae long before their "official" discovery in the Western World. Three of the four had been recorded as novae in early Chinese or Korean records. By 1896, 251 Mira-type variabes had been discovered, most of them after the beginning of photographic experimentation. Now in the year of the fourth centennial, over 6000 Miras are known. Because of their ease of discovery relative to stars of small amplitude, no new Mira stars reaching naked-eye visibility have been discovered since 1899. The history of the discovery of Mira-type variables illustrates that (1) some new discoveries are re-discoveries of objects previously assumed to be novae; and (2) apparently logical deductions that early observations of a guest star correspond to a later discovered Mire-type may nevertheless be wrong.

  15. The Methodological Unboundedness of Limited Discovery Processes

    Directory of Open Access Journals (Sweden)

    John Benjamin Cassel

    2014-12-01

    Full Text Available Though designers must understand systems, designers work differently than scientists in studying systems.  Design engagements do not discover whole systems, but take calculated risks between discovery and intervention. For this reason, design practices must cope with open systems, and unpacking the tacit guidelines behind these practices is instructive to systems methodology. This paper shows that design practice yields a methodology which applies across forms of design.  Design practice teaches us to generate ideas and gather data longer, but stop when the return on design has diminished past its cost.  Fortunately, we can reason about the unknown by understanding the character of the unbounded.  We suppose that there might as well be an infinite number of factors, but we can reason about their concentration without knowing all of them.  We demonstrate this concept on stakeholder systems, showing how design discovery informs systems methodology. Using this result, we can apply the methods of parametric design when the parameters are not yet known by establishing the concentration of every kind of factor, entailing a discovery rate of diminishing returns over discovery activities, allowing the analysis of discovery-based trade-offs.  Here, we extend a framework for providing metrics to parametric design, allowing it to express the importance of discovery.

  16. Implementation of a deidentified federated data network for population-based cohort discovery

    OpenAIRE

    Anderson, Nicholas; Abend, Aaron; Mandel, Aaron; Geraghty, Estella; Gabriel, Davera; Wynden, Rob; Kamerick, Michael; Anderson, Kent; Rainwater, Julie; Tarczy-Hornoch, Peter

    2011-01-01

    Objective The Cross-Institutional Clinical Translational Research project explored a federated query tool and looked at how this tool can facilitate clinical trial cohort discovery by managing access to aggregate patient data located within unaffiliated academic medical centers. Methods The project adapted software from the Informatics for Integrating Biology and the Bedside (i2b2) program to connect three Clinical Translational Research Award sites: University of Washington, Seattle, Univers...

  17. Stem cells: a model for screening, discovery and development of drugs

    OpenAIRE

    Kitambi SS; Chandrasekar G

    2011-01-01

    Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative medicine. The prospect of performing screens aimed at proliferation, directed differentiation, and toxicity and efficac...

  18. [The response to Wilhelm Conrad Röntgen's discovery in Berlin].

    Science.gov (United States)

    Schüttmann, W

    1995-01-01

    In early January 1896 Wilhelm Conrad Röntgen sent offprints to several colleagues of his to make them acquainted with his discovery of the X-rays. From January 5, 1896 newspapers started reporting on that discovery worldwide from Vienna. In several cities the news immediately set off corresponding scientific activities among specialists. This paper looks into such activities carried out in Berlin to show how promptly Röntgen's discovery was taken up, with a number of priorities having been set in the capital of the German Reich. The X-ray photographs which Röntgen had forwarded together with his offprints were displayed and discussed at a meeting of the Berlin Physical Society as early as on January 4, 1896, making his discovery known to the public for the first time. On January 6, 1896 the discovery and photographs were presented at a session of the Berlin Association of Internal Medicine and its diagnostic application was discussed in the medical community for the first time. A few days after that, the first photographs shot by other authors after Röntgen, and their diagnostic use, were demonstrated in Berlin. Finally, Röntgen's early visit to Emperor William II on January 12, 1896, which led to the speedy introduction of the X-day technique into German military medicine, is discussed in detail.

  19. Medications After the NICU

    Science.gov (United States)

    ... NICU) > Medications after the NICU Medications after the NICU E-mail to a friend Please fill in ... go home from the neonatal intensive care unit (NICU) on medication for apnea, reflux or respiratory problems. ...

  20. Medications: Myths Versus Facts

    Science.gov (United States)

    ... High Blood Pressure Tools & Resources Stroke More Medications: Myths Versus Facts Updated:Aug 30,2016 Taking medication ... Association volunteer. Here are some of the top myths about taking cardiovascular medication: I feel OK, so ...

  1. Asthma Medications and Pregnancy

    Science.gov (United States)

    ... MD Medical Director, Health Initiatives View full profile Asthma and Pregnancy: Asthma Medications We would like to avoid all medicine ... make sure you are using it correctly. Other Asthma Related Medication Treatment Annual influenza vaccine (flu shot) ...

  2. Medical alert bracelet (image)

    Science.gov (United States)

    People with diabetes should always wear a medical alert bracelet or necklace that emergency medical workers will be able to find. Medical identification products can help ensure proper treatment in an ...

  3. Medical contribution to the comprehensive approach.

    Science.gov (United States)

    Fletcher, J M

    2011-12-01

    The coordination of the Military, Diplomatic and Economic/Development levers of power, the so-called "hard" and "soft" powers, to bring about the strategic aims of governments, supported by Non-Governmental Organisations and international organisations, is commonly known as the Comprehensive Approach (CA). The CA is now part of both NATO and UK military doctrine and concepts development. This article describes how medical branch HQ Allied Rapid Reaction Corp, as part of the HQs work to operationalise the CA, has sought and developed training opportunities to improve individual skill-sets to enable the branch to better contribute to the CA process. PMID:22319985

  4. Practical design control implementation for medical devices

    CERN Document Server

    Justiniano, Jose

    2003-01-01

    Bringing together the concepts of design control and reliability engineering, this book is a must for medical device manufacturers. It helps them meet the challenge of designing and developing products that meet or exceed customer expectations and also meet regulatory requirements. Part One covers motivation for design control and validation, design control requirements, process validation and design transfer, quality system for design control, and measuring design control program effectiveness. Part Two discusses risk analysis and FMEA, designing-in reliability, reliability and design verific

  5. Duplicated leptin receptors in two species of eel bring new insights into the evolution of the leptin system in vertebrates.

    Directory of Open Access Journals (Sweden)

    Marina Morini

    Full Text Available Since its discovery in mammals as a key-hormone in reproduction and metabolism, leptin has been identified in an increasing number of tetrapods and teleosts. Tetrapods possess only one leptin gene, while most teleosts possess two leptin genes, as a result of the teleost third whole genome duplication event (3R. Leptin acts through a specific receptor (LEPR. In the European and Japanese eels, we identified two leptin genes, and for the first time in vertebrates, two LEPR genes. Synteny analyses indicated that eel LEPRa and LEPRb result from teleost 3R. LEPRb seems to have been lost in the teleost lineage shortly after the elopomorph divergence. Quantitative PCRs revealed a wide distribution of leptins and LEPRs in the European eel, including tissues involved in metabolism and reproduction. Noticeably, leptin1 was expressed in fat tissue, while leptin2 in the liver, reflecting subfunctionalization. Four-month fasting had no impact on the expression of leptins and LEPRs in control European eels. This might be related to the remarkable adaptation of silver eel metabolism to long-term fasting throughout the reproductive oceanic migration. In contrast, sexual maturation induced differential increases in the expression of leptins and LEPRs in the BPG-liver axis. Leptin2 was strikingly upregulated in the liver, the central organ of the reproductive metabolic challenge in teleosts. LEPRs were differentially regulated during sexual maturation, which may have contributed to the conservation of the duplicated LEPRs in this species. This suggests an ancient and positive role of the leptin system in the vertebrate reproductive function. This study brings new insights on the evolutionary history of the leptin system in vertebrates. Among extant vertebrates, the eel represents a unique case of duplicated leptins and leptin receptors as a result of 3R.

  6. Duplicated leptin receptors in two species of eel bring new insights into the evolution of the leptin system in vertebrates.

    Science.gov (United States)

    Morini, Marina; Pasquier, Jérémy; Dirks, Ron; van den Thillart, Guido; Tomkiewicz, Jonna; Rousseau, Karine; Dufour, Sylvie; Lafont, Anne-Gaëlle

    2015-01-01

    Since its discovery in mammals as a key-hormone in reproduction and metabolism, leptin has been identified in an increasing number of tetrapods and teleosts. Tetrapods possess only one leptin gene, while most teleosts possess two leptin genes, as a result of the teleost third whole genome duplication event (3R). Leptin acts through a specific receptor (LEPR). In the European and Japanese eels, we identified two leptin genes, and for the first time in vertebrates, two LEPR genes. Synteny analyses indicated that eel LEPRa and LEPRb result from teleost 3R. LEPRb seems to have been lost in the teleost lineage shortly after the elopomorph divergence. Quantitative PCRs revealed a wide distribution of leptins and LEPRs in the European eel, including tissues involved in metabolism and reproduction. Noticeably, leptin1 was expressed in fat tissue, while leptin2 in the liver, reflecting subfunctionalization. Four-month fasting had no impact on the expression of leptins and LEPRs in control European eels. This might be related to the remarkable adaptation of silver eel metabolism to long-term fasting throughout the reproductive oceanic migration. In contrast, sexual maturation induced differential increases in the expression of leptins and LEPRs in the BPG-liver axis. Leptin2 was strikingly upregulated in the liver, the central organ of the reproductive metabolic challenge in teleosts. LEPRs were differentially regulated during sexual maturation, which may have contributed to the conservation of the duplicated LEPRs in this species. This suggests an ancient and positive role of the leptin system in the vertebrate reproductive function. This study brings new insights on the evolutionary history of the leptin system in vertebrates. Among extant vertebrates, the eel represents a unique case of duplicated leptins and leptin receptors as a result of 3R.

  7. Cognitive Medical Multiagent Systems

    Directory of Open Access Journals (Sweden)

    Barna Iantovics

    2010-01-01

    Full Text Available The development of efficient and flexible agent-based medical diagnosis systems represents a recent research direction. Medical multiagent systems may improve the efficiency of traditionally developed medical computational systems, like the medical expert systems. In our previous researches, a novel cooperative medical diagnosis multiagent system called CMDS (Contract Net Based Medical Diagnosis System was proposed. CMDS system can solve flexibly a large variety of medical diagnosis problems. This paper analyses the increased intelligence of the CMDS system, which motivates its use for different medical problem’s solving.

  8. 18 CFR 385.908 - Discovery (Rule 908).

    Science.gov (United States)

    2010-04-01

    ... conduct discovery where such discovery relates to new facts or issues raised in accordance with Rule 907(b... discovery: (1) Relates to new facts or issues raised in accordance with Rule 907(c) (new facts and issues... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Discovery (Rule...

  9. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K–12 Community

    Directory of Open Access Journals (Sweden)

    David J. Westenberg

    2015-12-01

    Full Text Available Exposing K–12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS, “engaging in practices that scientists and engineers actually use.” This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM can play a critical role. ASM encourages its members to engage with the K–12 community by providing networking opportunities and resources for ASM members and K–12 teachers to work together to bring microbiology into the classroom.

  10. Forecasting Study on Demand and Supply of Medical Postgraduates

    Institute of Scientific and Technical Information of China (English)

    汪志宏; 赵志广; 黄畦; 吴森林; 卢祖洵

    2003-01-01

    This article was designed to forecast the supply and demand of medical postgraduate from 2001 to 2010 and bring forward the development strategy of medical postgraduate education in Hubei province. The line regression, the ratio of health manpower to population, grey dynamics model (1,1) was employed to forecast the supply and demand of medical postgraduate according to the corresponding data from 1991 to 2000 in Hubei province. The results showed that the number of health professionals of Hubei province in 2010 would attain 265892, the graduates' proportion of which would be about 1.8 % ; and the demand and supply of medical postgraduate would be 4699 and 2264 respectively. To improve conditions actively to attract and cultivate excellent professionals, especially the senior medical scholars, are effective measures to adjust the degree structure of health manpower as soon as possible in Hubei province.

  11. Information Discovery on Electronic Health Records

    CERN Document Server

    Hristidis, Vagelis

    2009-01-01

    Exploiting the information found in electronic health records (EHRs) can facilitate better medical research and improve the quality of medical practice. Addressing the challenges of leveraging this information, this book explores the technology to unleash the data stored in EHRs

  12. Keeping your medications organized

    Science.gov (United States)

    ... you take it Side effects Use a Regular Doctor and Pharmacist Bring the list and your medicines in their ... your medicines. Review your drug list with your doctor or pharmacist. Ask if there are any problems with taking ...

  13. Discovery-driven research and bioinformatics in nuclear receptor and coregulator signaling.

    Science.gov (United States)

    McKenna, Neil J

    2011-08-01

    Nuclear receptors (NRs) are a superfamily of ligand-regulated transcription factors that interact with coregulators and other transcription factors to direct tissue-specific programs of gene expression. Recent years have witnessed a rapid acceleration of the output of high-content data platforms in this field, generating discovery-driven datasets that have collectively described: the organization of the NR superfamily (phylogenomics); the expression patterns of NRs, coregulators and their target genes (transcriptomics); ligand- and tissue-specific functional NR and coregulator sites in DNA (cistromics); the organization of nuclear receptors and coregulators into higher order complexes (proteomics); and their downstream effects on homeostasis and metabolism (metabolomics). Significant bioinformatics challenges lie ahead both in the integration of this information into meaningful models of NR and coregulator biology, as well as in the archiving and communication of datasets to the global nuclear receptor signaling community. While holding great promise for the field, the ascendancy of discovery-driven research in this field brings with it a collective responsibility for researchers, publishers and funding agencies alike to ensure the effective archiving and management of these data. This review will discuss factors lying behind the increasing impact of discovery-driven research, examples of high-content datasets and their bioinformatic analysis, as well as a summary of currently curated web resources in this field. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. PMID:21029773

  14. What Does Galileo's Discovery of Jupiter's Moons Tell Us about the Process of Scientific Discovery?

    Science.gov (United States)

    Lawson, Anton E.

    2002-01-01

    Given that hypothetico-deductive reasoning has played a role in other important scientific discoveries, asks the question whether it plays a role in all important scientific discoveries. Explores and rejects as viable alternatives possible alternative scientific methods such as Baconian induction and combinatorial analysis. Discusses the…

  15. Stress and mental health among medical students

    Directory of Open Access Journals (Sweden)

    Backović Dušan V.

    2013-01-01

    Full Text Available Introduction. Medical studies bring many stressful activities to students. Prolonged stress can make adverse effects to mental health and lead to further professional burnout. Objective. The aim of this study was to assess the association of stress impact and adverse effects of medical studies with psychological distress among medical students. Methods. The cross sectional study was conducted on 367 fourth­year medical students of the Faculty of Medicine in Belgrade, by means of the anonymous questionnaire, containing: socio­demographic data, self­reported health status and stressful influences of studying activities. Mental health status was estimated by General Health Questionnaire (GHQ­12. Results. More than 50% of students perceive frequent feeling of psychic tension, and one third has problems with insomnia. Nearly one­half of students assessed their general stress level as moderate or high. Exams were estimated as high stressor in 63.1% of all students. Stressful effects of communication with teaching staff were reported by one quarter of the examinees. The scores of GHQ­12 were above the threshold in 55.6 % of all students. Mental health problems among students were most significantly associated with stressful experience during exams and contacts with teaching staff. Conclusion. Academic stress makes great influence on mental health of medical students. Reduction of stress effects should be directed to optimization of the examination process and improvement of communication skills. [Projekat Ministarstva nauke Republike Srbije, br. OI 175078

  16. Internet Naming and Discovery Architecture and Economics

    CERN Document Server

    Khoury, Joud S

    2013-01-01

    Naming is an integral building block within data networks and systems and is becoming ever more important as complex data-centric usage models emerge. Internet Naming and Discovery is timely in developing a unified model for studying the topic of naming and discovery. It details the architectural and economic tools needed for designing naming and discovery schemes within the broader context of internetwork architecture.   Readers will find in this book a historic overview of the Internet and a comprehensive survey of the literature, followed by and an in-depth examination of naming and discovery. Specific topics covered include: ·         formal definitions of name, address, identifier, locator, binding, routing, discovery, mapping, and resolution; ·         a discussion of the properties of names and bindings, along with illustrative case studies; ·         taxonomy that helps in organizing the solution space, and more importantly in identifying new avenues for contributing to the...

  17. Using C. elegans for antimicrobial drug discovery

    Science.gov (United States)

    Desalermos, Athanasios; Muhammed, Maged; Glavis-Bloom, Justin; Mylonakis, Eleftherios

    2011-01-01

    Introduction The number of microorganism strains with resistance to known antimicrobials is increasing. Therefore, there is a high demand for new, non-toxic and efficient antimicrobial agents. Research with the microscopic nematode Caenorhabditis elegans can address this high demand for the discovery of new antimicrobial compounds. In particular, C. elegans can be used as a model host for in vivo drug discovery through high-throughput screens of chemical libraries. Areas covered This review introduces the use of substitute model hosts and especially C. elegans in the study of microbial pathogenesis. The authors also highlight recently published literature on the role of C. elegans in drug discovery and outline its use as a promising host with unique advantages in the discovery of new antimicrobial drugs. Expert opinion C. elegans can be used, as a model host, to research many diseases, including fungal infections and Alzheimer’s disease. In addition, high-throughput techniques, for screening chemical libraries, can also be facilitated. Nevertheless, C. elegans and mammals have significant differences that both limit the use of the nematode in research and the degree by which results can be interpreted. That being said, the use of C. elegans in drug discovery still holds promise and the field continues to grow, with attempts to improve the methodology already underway. PMID:21686092

  18. On reliable discovery of molecular signatures

    Directory of Open Access Journals (Sweden)

    Björkegren Johan

    2009-01-01

    Full Text Available Abstract Background Molecular signatures are sets of genes, proteins, genetic variants or other variables that can be used as markers for a particular phenotype. Reliable signature discovery methods could yield valuable insight into cell biology and mechanisms of human disease. However, it is currently not clear how to control error rates such as the false discovery rate (FDR in signature discovery. Moreover, signatures for cancer gene expression have been shown to be unstable, that is, difficult to replicate in independent studies, casting doubts on their reliability. Results We demonstrate that with modern prediction methods, signatures that yield accurate predictions may still have a high FDR. Further, we show that even signatures with low FDR may fail to replicate in independent studies due to limited statistical power. Thus, neither stability nor predictive accuracy are relevant when FDR control is the primary goal. We therefore develop a general statistical hypothesis testing framework that for the first time provides FDR control for signature discovery. Our method is demonstrated to be correct in simulation studies. When applied to five cancer data sets, the method was able to discover molecular signatures with 5% FDR in three cases, while two data sets yielded no significant findings. Conclusion Our approach enables reliable discovery of molecular signatures from genome-wide data with current sample sizes. The statistical framework developed herein is potentially applicable to a wide range of prediction problems in bioinformatics.

  19. Facilitating Service Discovery with Semantic Overlay

    Institute of Scientific and Technical Information of China (English)

    Hai Jin; Hao Wu; Xiao-Min Ning

    2006-01-01

    Service Oriented Architecture (SOA) and Peer-to-Peer (P2P) computing share many common characteristics.It is believed that the combination of the two emerging techniques is a very promising method in promoting the web services (WS). Because the service discovery plays a key role in the integration, here a P2P-based framework to manage the knowledge of service and locating services is proposed. In this paper, the details of the principle, constructing and maintaining of service semantic overlay architecture have been described, and the way how the semantic overlay facilitates discovery of service resources is illustrated. To enable the semantic web service superiority, Service Ontology, which is considered as the service semantic model, is employed to depict service. The service discovery includes two phases: searching on the service semantic overlay; and local discovery in peer's service repository. Various solutions have been proposed to realize those two phases.Furthermore, tests are carried out to evaluate service discovery on the architecture.

  20. IYA2009 and Beyond - Update On "Music and Astronomy Under the Stars” To Bring Telescopes To Where the People Are!

    Science.gov (United States)

    Lubowich, Donald A.

    2009-05-01

    This NASA-funded Music and Astronomy Under the Stars outreach program brings telescopes and astronomy information (via a video display and outdoor exhibit) to community parks during and after music concerts and outdoor family films attended by 500 to 50,000 people. This program will permit the entire community to participate with telescope observations and will enhance the public appreciation of astronomy. The telescopes will be accessible to those with physical disabilities. This program combines music, telescope observations, and astronomy information and targets people who may not attend star parties, planetariums, or science museums. I update this program and discus the lessons learned such as the importance of coordination with local governments, community park districts, and amateur astronomer clubs. This program can be expanded and modified for the local communities. I have expanded this program to large and small venues from New York Philharmonic concert at Heckscher State Park, the boardwalk and a "tail-gate” star party by at pop-music concerts at Jones Beach State Park, and at the Tanglewood Music Festival in Lenox, MA, summer home of the Boston Symphony Orchestra (http://www.bso.org/bso/mods/perf_detail.jsp?pid=prod2880024). This program is expandable to include outdoor dance or theatre programs, festivals in parks or beaches or amusement parks. Music and Astronomy Under the Stars is program that should continue beyond IYA-2009 beaches. Special events such as a Super Bowl Star Party and Halloween Stars will be presented as will the results form NASA-funded hands-on astronomy activities to children and their families receiving medical treatment at the Children's Medical Center at Winthrop University Hospital (Mineola, NY) and the Ronald McDonald House of Long Island (New Hyde Park, NY).